id	sid	tid	token	lemma	pos
cord-299731-sis9952k	1	1	key	key	JJ
cord-299731-sis9952k	1	2	:	:	:
cord-299731-sis9952k	1	3	cord-299731-sis9952k	cord-299731-sis9952k	NNP
cord-299731-sis9952k	2	1	authors	author	NNS
cord-299731-sis9952k	2	2	:	:	:
cord-299731-sis9952k	2	3	Mehmel	Mehmel	NNP
cord-299731-sis9952k	2	4	,	,	,
cord-299731-sis9952k	2	5	Mario	Mario	NNP
cord-299731-sis9952k	2	6	;	;	:
cord-299731-sis9952k	2	7	Jovanović	Jovanović	NNP
cord-299731-sis9952k	2	8	,	,	,
cord-299731-sis9952k	2	9	Nina	Nina	NNP
cord-299731-sis9952k	2	10	;	;	:
cord-299731-sis9952k	2	11	Spitz	Spitz	NNP
cord-299731-sis9952k	2	12	,	,	,
cord-299731-sis9952k	2	13	Urs	Urs	NNP
cord-299731-sis9952k	2	14	title	title	NN
cord-299731-sis9952k	2	15	:	:	:
cord-299731-sis9952k	2	16	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	2	17	Riboside	Riboside	NNP
cord-299731-sis9952k	2	18	—	—	:
cord-299731-sis9952k	2	19	The	the	DT
cord-299731-sis9952k	2	20	Current	current	JJ
cord-299731-sis9952k	2	21	State	State	NNP
cord-299731-sis9952k	2	22	of	of	IN
cord-299731-sis9952k	2	23	Research	Research	NNP
cord-299731-sis9952k	2	24	and	and	CC
cord-299731-sis9952k	2	25	Therapeutic	therapeutic	JJ
cord-299731-sis9952k	2	26	Uses	Uses	NNP
cord-299731-sis9952k	2	27	date	date	NN
cord-299731-sis9952k	2	28	:	:	:
cord-299731-sis9952k	2	29	2020	2020	CD
cord-299731-sis9952k	2	30	-	-	HYPH
cord-299731-sis9952k	2	31	05	05	CD
cord-299731-sis9952k	2	32	-	-	HYPH
cord-299731-sis9952k	2	33	31	31	CD
cord-299731-sis9952k	2	34	journal	journal	NN
cord-299731-sis9952k	2	35	:	:	:
cord-299731-sis9952k	3	1	Nutrients	nutrient	NNS
cord-299731-sis9952k	3	2	DOI	DOI	NNP
cord-299731-sis9952k	3	3	:	:	:
cord-299731-sis9952k	4	1	10.3390	10.3390	CD
cord-299731-sis9952k	4	2	/	/	SYM
cord-299731-sis9952k	4	3	nu12061616	nu12061616	NNP
cord-299731-sis9952k	4	4	sha	sha	NNP
cord-299731-sis9952k	4	5	:	:	:
cord-299731-sis9952k	4	6	4e77793a506ecd2fe43ba944d5ffd0c1f3227c25	4e77793a506ecd2fe43ba944d5ffd0c1f3227c25	CD
cord-299731-sis9952k	4	7	doc_id	doc_id	CD
cord-299731-sis9952k	4	8	:	:	:
cord-299731-sis9952k	4	9	299731	299731	CD
cord-299731-sis9952k	4	10	cord_uid	cord_uid	NNS
cord-299731-sis9952k	4	11	:	:	:
cord-299731-sis9952k	4	12	sis9952k	sis9952k	NNP
cord-299731-sis9952k	4	13	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	4	14	riboside	riboside	NN
cord-299731-sis9952k	4	15	(	(	-LRB-
cord-299731-sis9952k	4	16	NR	NR	NNP
cord-299731-sis9952k	4	17	)	)	-RRB-
cord-299731-sis9952k	4	18	has	have	VBZ
cord-299731-sis9952k	4	19	recently	recently	RB
cord-299731-sis9952k	4	20	become	become	VBN
cord-299731-sis9952k	4	21	one	one	CD
cord-299731-sis9952k	4	22	of	of	IN
cord-299731-sis9952k	4	23	the	the	DT
cord-299731-sis9952k	4	24	most	most	RBS
cord-299731-sis9952k	4	25	studied	study	VBN
cord-299731-sis9952k	4	26	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	4	27	adenine	adenine	NN
cord-299731-sis9952k	4	28	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	4	29	(	(	-LRB-
cord-299731-sis9952k	4	30	NAD(+	nad(+	CD
cord-299731-sis9952k	4	31	)	)	-RRB-
cord-299731-sis9952k	4	32	)	)	-RRB-
cord-299731-sis9952k	4	33	precursors	precursor	NNS
cord-299731-sis9952k	4	34	,	,	,
cord-299731-sis9952k	4	35	due	due	IN
cord-299731-sis9952k	4	36	to	to	IN
cord-299731-sis9952k	4	37	its	-PRON-	PRP$
cord-299731-sis9952k	4	38	numerous	numerous	JJ
cord-299731-sis9952k	4	39	potential	potential	JJ
cord-299731-sis9952k	4	40	health	health	NN
cord-299731-sis9952k	4	41	benefits	benefit	NNS
cord-299731-sis9952k	4	42	mediated	mediate	VBN
cord-299731-sis9952k	4	43	via	via	IN
cord-299731-sis9952k	4	44	elevated	elevated	JJ
cord-299731-sis9952k	4	45	NAD(+	nad(+	CD
cord-299731-sis9952k	4	46	)	)	-RRB-
cord-299731-sis9952k	4	47	content	content	NN
cord-299731-sis9952k	4	48	in	in	IN
cord-299731-sis9952k	4	49	the	the	DT
cord-299731-sis9952k	4	50	body	body	NN
cord-299731-sis9952k	4	51	.	.	.
cord-299731-sis9952k	5	1	NAD(+	nad(+	LS
cord-299731-sis9952k	5	2	)	)	-RRB-
cord-299731-sis9952k	5	3	is	be	VBZ
cord-299731-sis9952k	5	4	an	an	DT
cord-299731-sis9952k	5	5	essential	essential	JJ
cord-299731-sis9952k	5	6	coenzyme	coenzyme	NNS
cord-299731-sis9952k	5	7	that	that	WDT
cord-299731-sis9952k	5	8	plays	play	VBZ
cord-299731-sis9952k	5	9	important	important	JJ
cord-299731-sis9952k	5	10	roles	role	NNS
cord-299731-sis9952k	5	11	in	in	IN
cord-299731-sis9952k	5	12	various	various	JJ
cord-299731-sis9952k	5	13	metabolic	metabolic	JJ
cord-299731-sis9952k	5	14	pathways	pathway	NNS
cord-299731-sis9952k	5	15	and	and	CC
cord-299731-sis9952k	5	16	increasing	increase	VBG
cord-299731-sis9952k	5	17	its	-PRON-	PRP$
cord-299731-sis9952k	5	18	overall	overall	JJ
cord-299731-sis9952k	5	19	content	content	NN
cord-299731-sis9952k	5	20	has	have	VBZ
cord-299731-sis9952k	5	21	been	be	VBN
cord-299731-sis9952k	5	22	confirmed	confirm	VBN
cord-299731-sis9952k	5	23	as	as	IN
cord-299731-sis9952k	5	24	a	a	DT
cord-299731-sis9952k	5	25	valuable	valuable	JJ
cord-299731-sis9952k	5	26	strategy	strategy	NN
cord-299731-sis9952k	5	27	for	for	IN
cord-299731-sis9952k	5	28	treating	treat	VBG
cord-299731-sis9952k	5	29	a	a	DT
cord-299731-sis9952k	5	30	wide	wide	JJ
cord-299731-sis9952k	5	31	variety	variety	NN
cord-299731-sis9952k	5	32	of	of	IN
cord-299731-sis9952k	5	33	pathophysiological	pathophysiological	JJ
cord-299731-sis9952k	5	34	conditions	condition	NNS
cord-299731-sis9952k	5	35	.	.	.
cord-299731-sis9952k	6	1	Accumulating	accumulate	VBG
cord-299731-sis9952k	6	2	evidence	evidence	NN
cord-299731-sis9952k	6	3	on	on	IN
cord-299731-sis9952k	6	4	NRs	NRs	NNP
cord-299731-sis9952k	6	5	’	’	POS
cord-299731-sis9952k	6	6	health	health	NN
cord-299731-sis9952k	6	7	benefits	benefit	NNS
cord-299731-sis9952k	6	8	has	have	VBZ
cord-299731-sis9952k	6	9	validated	validate	VBN
cord-299731-sis9952k	6	10	its	-PRON-	PRP$
cord-299731-sis9952k	6	11	efficiency	efficiency	NN
cord-299731-sis9952k	6	12	across	across	IN
cord-299731-sis9952k	6	13	numerous	numerous	JJ
cord-299731-sis9952k	6	14	animal	animal	NN
cord-299731-sis9952k	6	15	and	and	CC
cord-299731-sis9952k	6	16	human	human	JJ
cord-299731-sis9952k	6	17	studies	study	NNS
cord-299731-sis9952k	6	18	for	for	IN
cord-299731-sis9952k	6	19	the	the	DT
cord-299731-sis9952k	6	20	treatment	treatment	NN
cord-299731-sis9952k	6	21	of	of	IN
cord-299731-sis9952k	6	22	a	a	DT
cord-299731-sis9952k	6	23	number	number	NN
cord-299731-sis9952k	6	24	of	of	IN
cord-299731-sis9952k	6	25	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	6	26	,	,	,
cord-299731-sis9952k	6	27	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	6	28	,	,	,
cord-299731-sis9952k	6	29	and	and	CC
cord-299731-sis9952k	6	30	metabolic	metabolic	JJ
cord-299731-sis9952k	6	31	disorders	disorder	NNS
cord-299731-sis9952k	6	32	.	.	.
cord-299731-sis9952k	7	1	As	as	IN
cord-299731-sis9952k	7	2	the	the	DT
cord-299731-sis9952k	7	3	prevalence	prevalence	NN
cord-299731-sis9952k	7	4	and	and	CC
cord-299731-sis9952k	7	5	morbidity	morbidity	NN
cord-299731-sis9952k	7	6	of	of	IN
cord-299731-sis9952k	7	7	these	these	DT
cord-299731-sis9952k	7	8	conditions	condition	NNS
cord-299731-sis9952k	7	9	increases	increase	NNS
cord-299731-sis9952k	7	10	in	in	IN
cord-299731-sis9952k	7	11	modern	modern	JJ
cord-299731-sis9952k	7	12	society	society	NN
cord-299731-sis9952k	7	13	,	,	,
cord-299731-sis9952k	7	14	the	the	DT
cord-299731-sis9952k	7	15	great	great	JJ
cord-299731-sis9952k	7	16	necessity	necessity	NN
cord-299731-sis9952k	7	17	has	have	VBZ
cord-299731-sis9952k	7	18	arisen	arise	VBN
cord-299731-sis9952k	7	19	for	for	IN
cord-299731-sis9952k	7	20	a	a	DT
cord-299731-sis9952k	7	21	rapid	rapid	JJ
cord-299731-sis9952k	7	22	translation	translation	NN
cord-299731-sis9952k	7	23	of	of	IN
cord-299731-sis9952k	7	24	NR	NR	NNP
cord-299731-sis9952k	7	25	to	to	IN
cord-299731-sis9952k	7	26	therapeutic	therapeutic	JJ
cord-299731-sis9952k	7	27	use	use	NN
cord-299731-sis9952k	7	28	and	and	CC
cord-299731-sis9952k	7	29	further	further	JJ
cord-299731-sis9952k	7	30	establishment	establishment	NN
cord-299731-sis9952k	7	31	of	of	IN
cord-299731-sis9952k	7	32	its	-PRON-	PRP$
cord-299731-sis9952k	7	33	availability	availability	NN
cord-299731-sis9952k	7	34	as	as	IN
cord-299731-sis9952k	7	35	a	a	DT
cord-299731-sis9952k	7	36	nutritional	nutritional	JJ
cord-299731-sis9952k	7	37	supplement	supplement	NN
cord-299731-sis9952k	7	38	.	.	.
cord-299731-sis9952k	8	1	Here	here	RB
cord-299731-sis9952k	8	2	,	,	,
cord-299731-sis9952k	8	3	we	-PRON-	PRP
cord-299731-sis9952k	8	4	summarize	summarize	VBP
cord-299731-sis9952k	8	5	currently	currently	RB
cord-299731-sis9952k	8	6	available	available	JJ
cord-299731-sis9952k	8	7	data	datum	NNS
cord-299731-sis9952k	8	8	on	on	IN
cord-299731-sis9952k	8	9	NR	NR	NNP
cord-299731-sis9952k	8	10	effects	effect	NNS
cord-299731-sis9952k	8	11	on	on	IN
cord-299731-sis9952k	8	12	metabolism	metabolism	NN
cord-299731-sis9952k	8	13	,	,	,
cord-299731-sis9952k	8	14	and	and	CC
cord-299731-sis9952k	8	15	several	several	JJ
cord-299731-sis9952k	8	16	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	8	17	and	and	CC
cord-299731-sis9952k	8	18	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	8	19	disorders	disorder	NNS
cord-299731-sis9952k	8	20	,	,	,
cord-299731-sis9952k	8	21	through	through	IN
cord-299731-sis9952k	8	22	to	to	IN
cord-299731-sis9952k	8	23	its	-PRON-	PRP$
cord-299731-sis9952k	8	24	application	application	NN
cord-299731-sis9952k	8	25	as	as	IN
cord-299731-sis9952k	8	26	a	a	DT
cord-299731-sis9952k	8	27	treatment	treatment	NN
cord-299731-sis9952k	8	28	for	for	IN
cord-299731-sis9952k	8	29	specific	specific	JJ
cord-299731-sis9952k	8	30	pathophysiological	pathophysiological	JJ
cord-299731-sis9952k	8	31	conditions	condition	NNS
cord-299731-sis9952k	8	32	.	.	.
cord-299731-sis9952k	9	1	In	in	IN
cord-299731-sis9952k	9	2	addition	addition	NN
cord-299731-sis9952k	9	3	,	,	,
cord-299731-sis9952k	9	4	we	-PRON-	PRP
cord-299731-sis9952k	9	5	have	have	VBP
cord-299731-sis9952k	9	6	reviewed	review	VBN
cord-299731-sis9952k	9	7	newly	newly	RB
cord-299731-sis9952k	9	8	published	publish	VBN
cord-299731-sis9952k	9	9	research	research	NN
cord-299731-sis9952k	9	10	on	on	IN
cord-299731-sis9952k	9	11	the	the	DT
cord-299731-sis9952k	9	12	application	application	NN
cord-299731-sis9952k	9	13	of	of	IN
cord-299731-sis9952k	9	14	NR	NR	NNP
cord-299731-sis9952k	9	15	as	as	IN
cord-299731-sis9952k	9	16	a	a	DT
cord-299731-sis9952k	9	17	potential	potential	JJ
cord-299731-sis9952k	9	18	therapy	therapy	NN
cord-299731-sis9952k	9	19	against	against	IN
cord-299731-sis9952k	9	20	infections	infection	NNS
cord-299731-sis9952k	9	21	with	with	IN
cord-299731-sis9952k	9	22	several	several	JJ
cord-299731-sis9952k	9	23	pathogens	pathogen	NNS
cord-299731-sis9952k	9	24	,	,	,
cord-299731-sis9952k	9	25	including	include	VBG
cord-299731-sis9952k	9	26	SARS	SARS	NNP
cord-299731-sis9952k	9	27	-	-	HYPH
cord-299731-sis9952k	9	28	CoV-2	CoV-2	NNP
cord-299731-sis9952k	9	29	.	.	.
cord-299731-sis9952k	10	1	Additionally	additionally	RB
cord-299731-sis9952k	10	2	,	,	,
cord-299731-sis9952k	10	3	to	to	TO
cord-299731-sis9952k	10	4	support	support	VB
cord-299731-sis9952k	10	5	rapid	rapid	JJ
cord-299731-sis9952k	10	6	NR	NR	NNP
cord-299731-sis9952k	10	7	translation	translation	NN
cord-299731-sis9952k	10	8	to	to	IN
cord-299731-sis9952k	10	9	therapeutics	therapeutic	NNS
cord-299731-sis9952k	10	10	,	,	,
cord-299731-sis9952k	10	11	the	the	DT
cord-299731-sis9952k	10	12	challenges	challenge	NNS
cord-299731-sis9952k	10	13	related	relate	VBN
cord-299731-sis9952k	10	14	to	to	IN
cord-299731-sis9952k	10	15	its	-PRON-	PRP$
cord-299731-sis9952k	10	16	bioavailability	bioavailability	NN
cord-299731-sis9952k	10	17	and	and	CC
cord-299731-sis9952k	10	18	safety	safety	NN
cord-299731-sis9952k	10	19	are	be	VBP
cord-299731-sis9952k	10	20	addressed	address	VBN
cord-299731-sis9952k	10	21	,	,	,
cord-299731-sis9952k	10	22	together	together	RB
cord-299731-sis9952k	10	23	with	with	IN
cord-299731-sis9952k	10	24	the	the	DT
cord-299731-sis9952k	10	25	advantages	advantage	NNS
cord-299731-sis9952k	10	26	of	of	IN
cord-299731-sis9952k	10	27	NR	NR	NNP
cord-299731-sis9952k	10	28	to	to	IN
cord-299731-sis9952k	10	29	other	other	JJ
cord-299731-sis9952k	10	30	NAD(+	nad(+	CD
cord-299731-sis9952k	10	31	)	)	-RRB-
cord-299731-sis9952k	10	32	precursors	precursor	NNS
cord-299731-sis9952k	10	33	.	.	.
cord-299731-sis9952k	11	1	In	in	IN
cord-299731-sis9952k	11	2	recent	recent	JJ
cord-299731-sis9952k	11	3	years	year	NNS
cord-299731-sis9952k	11	4	,	,	,
cord-299731-sis9952k	11	5	interest	interest	NN
cord-299731-sis9952k	11	6	in	in	IN
cord-299731-sis9952k	11	7	NAD	NAD	NNP
cord-299731-sis9952k	11	8	+	+	CC
cord-299731-sis9952k	11	9	biology	biology	NN
cord-299731-sis9952k	11	10	has	have	VBZ
cord-299731-sis9952k	11	11	been	be	VBN
cord-299731-sis9952k	11	12	gaining	gain	VBG
cord-299731-sis9952k	11	13	momentum	momentum	NN
cord-299731-sis9952k	11	14	,	,	,
cord-299731-sis9952k	11	15	revealing	reveal	VBG
cord-299731-sis9952k	11	16	critical	critical	JJ
cord-299731-sis9952k	11	17	insights	insight	NNS
cord-299731-sis9952k	11	18	into	into	IN
cord-299731-sis9952k	11	19	its	-PRON-	PRP$
cord-299731-sis9952k	11	20	roles	role	NNS
cord-299731-sis9952k	11	21	in	in	IN
cord-299731-sis9952k	11	22	numerous	numerous	JJ
cord-299731-sis9952k	11	23	physiological	physiological	JJ
cord-299731-sis9952k	11	24	processes	process	NNS
cord-299731-sis9952k	11	25	and	and	CC
cord-299731-sis9952k	11	26	underlining	underline	VBG
cord-299731-sis9952k	11	27	the	the	DT
cord-299731-sis9952k	11	28	beneficial	beneficial	JJ
cord-299731-sis9952k	11	29	effects	effect	NNS
cord-299731-sis9952k	11	30	of	of	IN
cord-299731-sis9952k	11	31	supplementation	supplementation	NN
cord-299731-sis9952k	11	32	with	with	IN
cord-299731-sis9952k	11	33	its	-PRON-	PRP$
cord-299731-sis9952k	11	34	precursors	precursor	NNS
cord-299731-sis9952k	11	35	.	.	.
cord-299731-sis9952k	12	1	Moreover	moreover	RB
cord-299731-sis9952k	12	2	,	,	,
cord-299731-sis9952k	12	3	accumulating	accumulate	VBG
cord-299731-sis9952k	12	4	evidence	evidence	NN
cord-299731-sis9952k	12	5	indicates	indicate	VBZ
cord-299731-sis9952k	12	6	that	that	IN
cord-299731-sis9952k	12	7	a	a	DT
cord-299731-sis9952k	12	8	decrease	decrease	NN
cord-299731-sis9952k	12	9	in	in	IN
cord-299731-sis9952k	12	10	NAD	NAD	NNP
cord-299731-sis9952k	12	11	+	+	CC
cord-299731-sis9952k	12	12	levels	level	NNS
cord-299731-sis9952k	12	13	contributes	contribute	VBZ
cord-299731-sis9952k	12	14	to	to	IN
cord-299731-sis9952k	12	15	the	the	DT
cord-299731-sis9952k	12	16	development	development	NN
cord-299731-sis9952k	12	17	of	of	IN
cord-299731-sis9952k	12	18	age	age	NN
cord-299731-sis9952k	12	19	-	-	HYPH
cord-299731-sis9952k	12	20	associated	associate	VBN
cord-299731-sis9952k	12	21	pathophysiology	pathophysiology	NN
cord-299731-sis9952k	12	22	[	[	-LRB-
cord-299731-sis9952k	12	23	1	1	CD
cord-299731-sis9952k	12	24	]	]	-RRB-
cord-299731-sis9952k	12	25	[	[	-LRB-
cord-299731-sis9952k	12	26	2	2	CD
cord-299731-sis9952k	12	27	]	]	-RRB-
cord-299731-sis9952k	12	28	[	[	-LRB-
cord-299731-sis9952k	12	29	3	3	CD
cord-299731-sis9952k	12	30	]	]	-RRB-
cord-299731-sis9952k	12	31	.	.	.
cord-299731-sis9952k	13	1	The	the	DT
cord-299731-sis9952k	13	2	systemic	systemic	JJ
cord-299731-sis9952k	13	3	NAD	NAD	NNP
cord-299731-sis9952k	13	4	+	+	CC
cord-299731-sis9952k	13	5	decrease	decrease	NN
cord-299731-sis9952k	13	6	is	be	VBZ
cord-299731-sis9952k	13	7	caused	cause	VBN
cord-299731-sis9952k	13	8	by	by	IN
cord-299731-sis9952k	13	9	both	both	DT
cord-299731-sis9952k	13	10	lowered	lower	VBN
cord-299731-sis9952k	13	11	rates	rate	NNS
cord-299731-sis9952k	13	12	of	of	IN
cord-299731-sis9952k	13	13	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	13	14	and	and	CC
cord-299731-sis9952k	13	15	increased	increase	VBN
cord-299731-sis9952k	13	16	use	use	NN
cord-299731-sis9952k	13	17	of	of	IN
cord-299731-sis9952k	13	18	NAD	NAD	NNP
cord-299731-sis9952k	13	19	+	+	CC
cord-299731-sis9952k	13	20	.	.	.
cord-299731-sis9952k	14	1	The	the	DT
cord-299731-sis9952k	14	2	immense	immense	JJ
cord-299731-sis9952k	14	3	demand	demand	NN
cord-299731-sis9952k	14	4	for	for	IN
cord-299731-sis9952k	14	5	NAD	NAD	NNP
cord-299731-sis9952k	14	6	+	+	CC
cord-299731-sis9952k	14	7	is	be	VBZ
cord-299731-sis9952k	14	8	caused	cause	VBN
cord-299731-sis9952k	14	9	by	by	IN
cord-299731-sis9952k	14	10	its	-PRON-	PRP$
cord-299731-sis9952k	14	11	importance	importance	NN
cord-299731-sis9952k	14	12	in	in	IN
cord-299731-sis9952k	14	13	cellular	cellular	JJ
cord-299731-sis9952k	14	14	oxidation	oxidation	NN
cord-299731-sis9952k	14	15	-	-	HYPH
cord-299731-sis9952k	14	16	reduction	reduction	NN
cord-299731-sis9952k	14	17	reactions	reaction	NNS
cord-299731-sis9952k	14	18	,	,	,
cord-299731-sis9952k	14	19	including	include	VBG
cord-299731-sis9952k	14	20	the	the	DT
cord-299731-sis9952k	14	21	majority	majority	NN
cord-299731-sis9952k	14	22	of	of	IN
cord-299731-sis9952k	14	23	catabolic	catabolic	JJ
cord-299731-sis9952k	14	24	and	and	CC
cord-299731-sis9952k	14	25	anabolic	anabolic	JJ
cord-299731-sis9952k	14	26	reactions	reaction	NNS
cord-299731-sis9952k	14	27	,	,	,
cord-299731-sis9952k	14	28	such	such	JJ
cord-299731-sis9952k	14	29	as	as	IN
cord-299731-sis9952k	14	30	glycolysis	glycolysis	NN
cord-299731-sis9952k	14	31	,	,	,
cord-299731-sis9952k	14	32	fatty	fatty	JJ
cord-299731-sis9952k	14	33	acid	acid	NN
cord-299731-sis9952k	14	34	β	β	NN
cord-299731-sis9952k	14	35	-	-	HYPH
cord-299731-sis9952k	14	36	oxidation	oxidation	NN
cord-299731-sis9952k	14	37	,	,	,
cord-299731-sis9952k	14	38	tricarboxylic	tricarboxylic	JJ
cord-299731-sis9952k	14	39	acid	acid	NN
cord-299731-sis9952k	14	40	cycle	cycle	NN
cord-299731-sis9952k	14	41	,	,	,
cord-299731-sis9952k	14	42	synthesis	synthesis	NN
cord-299731-sis9952k	14	43	of	of	IN
cord-299731-sis9952k	14	44	fatty	fatty	JJ
cord-299731-sis9952k	14	45	acids	acid	NNS
cord-299731-sis9952k	14	46	,	,	,
cord-299731-sis9952k	14	47	cholesterol	cholesterol	NN
cord-299731-sis9952k	14	48	,	,	,
cord-299731-sis9952k	14	49	steroids	steroid	NNS
cord-299731-sis9952k	14	50	,	,	,
cord-299731-sis9952k	14	51	etc	etc	FW
cord-299731-sis9952k	14	52	.	.	.
cord-299731-sis9952k	15	1	[	[	-LRB-
cord-299731-sis9952k	15	2	4	4	CD
cord-299731-sis9952k	15	3	]	]	-RRB-
cord-299731-sis9952k	15	4	[	[	-LRB-
cord-299731-sis9952k	15	5	5	5	CD
cord-299731-sis9952k	15	6	]	]	-RRB-
cord-299731-sis9952k	15	7	[	[	-LRB-
cord-299731-sis9952k	15	8	6	6	CD
cord-299731-sis9952k	15	9	]	]	-RRB-
cord-299731-sis9952k	15	10	.	.	.
cord-299731-sis9952k	16	1	Additionally	additionally	RB
cord-299731-sis9952k	16	2	,	,	,
cord-299731-sis9952k	16	3	NAD	NAD	NNP
cord-299731-sis9952k	16	4	+	+	CC
cord-299731-sis9952k	16	5	-consuming	-consuming	NN
cord-299731-sis9952k	16	6	enzymes	enzyme	NNS
cord-299731-sis9952k	16	7	,	,	,
cord-299731-sis9952k	16	8	such	such	JJ
cord-299731-sis9952k	16	9	as	as	IN
cord-299731-sis9952k	16	10	sirtuins	sirtuin	NNS
cord-299731-sis9952k	16	11	,	,	,
cord-299731-sis9952k	16	12	poly	poly	JJ
cord-299731-sis9952k	16	13	-	-	HYPH
cord-299731-sis9952k	16	14	ADP	adp	NN
cord-299731-sis9952k	16	15	-	-	HYPH
cord-299731-sis9952k	16	16	ribose	ribose	NN
cord-299731-sis9952k	16	17	polymerases	polymerase	NNS
cord-299731-sis9952k	16	18	(	(	-LRB-
cord-299731-sis9952k	16	19	PARPs	PARPs	NNPS
cord-299731-sis9952k	16	20	)	)	-RRB-
cord-299731-sis9952k	16	21	,	,	,
cord-299731-sis9952k	16	22	cADP	cadp	JJ
cord-299731-sis9952k	16	23	-	-	HYPH
cord-299731-sis9952k	16	24	ribose	ribose	NN
cord-299731-sis9952k	16	25	synthases	synthase	NNS
cord-299731-sis9952k	16	26	(	(	-LRB-
cord-299731-sis9952k	16	27	CD38/157	cd38/157	PRP$
cord-299731-sis9952k	16	28	ectoenzymes	ectoenzymes	VBP
cord-299731-sis9952k	16	29	)	)	-RRB-
cord-299731-sis9952k	16	30	[	[	-LRB-
cord-299731-sis9952k	16	31	7	7	CD
cord-299731-sis9952k	16	32	]	]	-RRB-
cord-299731-sis9952k	16	33	[	[	-LRB-
cord-299731-sis9952k	16	34	8	8	CD
cord-299731-sis9952k	16	35	]	]	-RRB-
cord-299731-sis9952k	16	36	[	[	-LRB-
cord-299731-sis9952k	16	37	9	9	CD
cord-299731-sis9952k	16	38	]	]	-RRB-
cord-299731-sis9952k	16	39	and	and	CC
cord-299731-sis9952k	16	40	mono	mono	JJ
cord-299731-sis9952k	16	41	-	-	HYPH
cord-299731-sis9952k	16	42	ADP	adp	JJ
cord-299731-sis9952k	16	43	-	-	HYPH
cord-299731-sis9952k	16	44	ribose	ribose	NN
cord-299731-sis9952k	16	45	transferases	transferase	NNS
cord-299731-sis9952k	16	46	(	(	-LRB-
cord-299731-sis9952k	16	47	ARTs	art	NNS
cord-299731-sis9952k	16	48	)	)	-RRB-
cord-299731-sis9952k	16	49	contribute	contribute	VB
cord-299731-sis9952k	16	50	to	to	IN
cord-299731-sis9952k	16	51	an	an	DT
cord-299731-sis9952k	16	52	overall	overall	JJ
cord-299731-sis9952k	16	53	depletion	depletion	NN
cord-299731-sis9952k	16	54	of	of	IN
cord-299731-sis9952k	16	55	NAD	NAD	NNP
cord-299731-sis9952k	16	56	+	+	CC
cord-299731-sis9952k	16	57	.	.	.
cord-299731-sis9952k	17	1	Biosynthesis	Biosynthesis	NNP
cord-299731-sis9952k	17	2	can	can	MD
cord-299731-sis9952k	17	3	compensate	compensate	VB
cord-299731-sis9952k	17	4	somewhat	somewhat	RB
cord-299731-sis9952k	17	5	to	to	IN
cord-299731-sis9952k	17	6	the	the	DT
cord-299731-sis9952k	17	7	depleted	deplete	VBN
cord-299731-sis9952k	17	8	levels	level	NNS
cord-299731-sis9952k	17	9	of	of	IN
cord-299731-sis9952k	17	10	NAD	NAD	NNP
cord-299731-sis9952k	17	11	+	+	CC
cord-299731-sis9952k	17	12	via	via	IN
cord-299731-sis9952k	17	13	de	de	NNP
cord-299731-sis9952k	17	14	novo	novo	NNP
cord-299731-sis9952k	17	15	synthesis	synthesis	NN
cord-299731-sis9952k	17	16	from	from	IN
cord-299731-sis9952k	17	17	tryptophan	tryptophan	NN
cord-299731-sis9952k	17	18	(	(	-LRB-
cord-299731-sis9952k	17	19	Trp	Trp	NNP
cord-299731-sis9952k	17	20	)	)	-RRB-
cord-299731-sis9952k	17	21	or	or	CC
cord-299731-sis9952k	17	22	in	in	IN
cord-299731-sis9952k	17	23	the	the	DT
cord-299731-sis9952k	17	24	salvage	salvage	NN
cord-299731-sis9952k	17	25	pathways	pathway	NNS
cord-299731-sis9952k	17	26	from	from	IN
cord-299731-sis9952k	17	27	four	four	CD
cord-299731-sis9952k	17	28	other	other	JJ
cord-299731-sis9952k	17	29	precursors	precursor	NNS
cord-299731-sis9952k	17	30	,	,	,
cord-299731-sis9952k	17	31	Figure	figure	NN
cord-299731-sis9952k	17	32	1	1	CD
cord-299731-sis9952k	17	33	.	.	.
cord-299731-sis9952k	18	1	NAD	NAD	NNP
cord-299731-sis9952k	18	2	+	+	CC
cord-299731-sis9952k	18	3	synthesis	synthesis	NN
cord-299731-sis9952k	18	4	pathways	pathway	NNS
cord-299731-sis9952k	18	5	.	.	.
cord-299731-sis9952k	19	1	The	the	DT
cord-299731-sis9952k	19	2	figure	figure	NN
cord-299731-sis9952k	19	3	depicts	depict	VBZ
cord-299731-sis9952k	19	4	NAD	NAD	NNP
cord-299731-sis9952k	19	5	+	+	CC
cord-299731-sis9952k	19	6	de	de	FW
cord-299731-sis9952k	19	7	novo	novo	NNP
cord-299731-sis9952k	19	8	pathway	pathway	NN
cord-299731-sis9952k	19	9	from	from	IN
cord-299731-sis9952k	19	10	tryptophan	tryptophan	NN
cord-299731-sis9952k	19	11	(	(	-LRB-
cord-299731-sis9952k	19	12	Trp	Trp	NNP
cord-299731-sis9952k	19	13	)	)	-RRB-
cord-299731-sis9952k	19	14	through	through	IN
cord-299731-sis9952k	19	15	quinolinic	quinolinic	NNP
cord-299731-sis9952k	19	16	acid	acid	NNP
cord-299731-sis9952k	19	17	(	(	-LRB-
cord-299731-sis9952k	19	18	QA	QA	NNP
cord-299731-sis9952k	19	19	)	)	-RRB-
cord-299731-sis9952k	19	20	,	,	,
cord-299731-sis9952k	19	21	Preiss	Preiss	NNP
cord-299731-sis9952k	19	22	-	-	HYPH
cord-299731-sis9952k	19	23	Handler	Handler	NNP
cord-299731-sis9952k	19	24	pathway	pathway	NN
cord-299731-sis9952k	19	25	from	from	IN
cord-299731-sis9952k	19	26	nicotinic	nicotinic	JJ
cord-299731-sis9952k	19	27	acid	acid	NN
cord-299731-sis9952k	19	28	(	(	-LRB-
cord-299731-sis9952k	19	29	NA	NA	NNP
cord-299731-sis9952k	19	30	)	)	-RRB-
cord-299731-sis9952k	19	31	via	via	IN
cord-299731-sis9952k	19	32	nicotinic	nicotinic	JJ
cord-299731-sis9952k	19	33	acid	acid	NN
cord-299731-sis9952k	19	34	adenine	adenine	NN
cord-299731-sis9952k	19	35	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	19	36	(	(	-LRB-
cord-299731-sis9952k	19	37	NAAD	NAAD	NNP
cord-299731-sis9952k	19	38	)	)	-RRB-
cord-299731-sis9952k	19	39	and	and	CC
cord-299731-sis9952k	19	40	NAD	NAD	NNP
cord-299731-sis9952k	19	41	synthetase	synthetase	NN
cord-299731-sis9952k	19	42	(	(	-LRB-
cord-299731-sis9952k	19	43	NADS	NADS	NNP
cord-299731-sis9952k	19	44	)	)	-RRB-
cord-299731-sis9952k	19	45	,	,	,
cord-299731-sis9952k	19	46	and	and	CC
cord-299731-sis9952k	19	47	"	"	``
cord-299731-sis9952k	19	48	salvage	salvage	NN
cord-299731-sis9952k	19	49	pathways	pathway	NNS
cord-299731-sis9952k	19	50	"	"	''
cord-299731-sis9952k	19	51	from	from	IN
cord-299731-sis9952k	19	52	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	19	53	riboside	riboside	NN
cord-299731-sis9952k	19	54	(	(	-LRB-
cord-299731-sis9952k	19	55	NR	NR	NNP
cord-299731-sis9952k	19	56	)	)	-RRB-
cord-299731-sis9952k	19	57	and	and	CC
cord-299731-sis9952k	19	58	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	19	59	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	19	60	(	(	-LRB-
cord-299731-sis9952k	19	61	NMN	NMN	NNP
cord-299731-sis9952k	19	62	)	)	-RRB-
cord-299731-sis9952k	20	1	via	via	IN
cord-299731-sis9952k	20	2	purine	purine	NN
cord-299731-sis9952k	20	3	nucleoside	nucleoside	NN
cord-299731-sis9952k	20	4	phosphorylase	phosphorylase	NN
cord-299731-sis9952k	20	5	(	(	-LRB-
cord-299731-sis9952k	20	6	NP	NP	NNP
cord-299731-sis9952k	20	7	)	)	-RRB-
cord-299731-sis9952k	20	8	and	and	CC
cord-299731-sis9952k	20	9	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	20	10	phosphoribosyltransferase	phosphoribosyltransferase	NN
cord-299731-sis9952k	20	11	(	(	-LRB-
cord-299731-sis9952k	20	12	NAMPT	NAMPT	NNP
cord-299731-sis9952k	20	13	)	)	-RRB-
cord-299731-sis9952k	20	14	enzymes	enzyme	NNS
cord-299731-sis9952k	20	15	or	or	CC
cord-299731-sis9952k	20	16	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	20	17	ribose	ribose	NN
cord-299731-sis9952k	20	18	kinases	kinase	NNS
cord-299731-sis9952k	20	19	(	(	-LRB-
cord-299731-sis9952k	20	20	NRK	NRK	NNP
cord-299731-sis9952k	20	21	)	)	-RRB-
cord-299731-sis9952k	20	22	and	and	CC
cord-299731-sis9952k	20	23	NMN	NMN	NNP
cord-299731-sis9952k	20	24	/	/	SYM
cord-299731-sis9952k	20	25	NaMN	NaMN	NNP
cord-299731-sis9952k	20	26	adenylyltransferases	adenylyltransferase	NNS
cord-299731-sis9952k	20	27	(	(	-LRB-
cord-299731-sis9952k	20	28	NMNAT	NMNAT	NNP
cord-299731-sis9952k	20	29	)	)	-RRB-
cord-299731-sis9952k	20	30	,	,	,
cord-299731-sis9952k	20	31	respectively	respectively	RB
cord-299731-sis9952k	20	32	.	.	.
cord-299731-sis9952k	21	1	Figure	figure	NN
cord-299731-sis9952k	21	2	1	1	CD
cord-299731-sis9952k	21	3	.	.	.
cord-299731-sis9952k	22	1	NAD	NAD	NNP
cord-299731-sis9952k	22	2	+	+	CC
cord-299731-sis9952k	22	3	synthesis	synthesis	NN
cord-299731-sis9952k	22	4	pathways	pathway	NNS
cord-299731-sis9952k	22	5	.	.	.
cord-299731-sis9952k	23	1	The	the	DT
cord-299731-sis9952k	23	2	figure	figure	NN
cord-299731-sis9952k	23	3	depicts	depict	VBZ
cord-299731-sis9952k	23	4	NAD	NAD	NNP
cord-299731-sis9952k	23	5	+	+	CC
cord-299731-sis9952k	23	6	de	de	FW
cord-299731-sis9952k	23	7	novo	novo	NNP
cord-299731-sis9952k	23	8	pathway	pathway	NN
cord-299731-sis9952k	23	9	from	from	IN
cord-299731-sis9952k	23	10	tryptophan	tryptophan	NN
cord-299731-sis9952k	23	11	(	(	-LRB-
cord-299731-sis9952k	23	12	Trp	Trp	NNP
cord-299731-sis9952k	23	13	)	)	-RRB-
cord-299731-sis9952k	23	14	through	through	IN
cord-299731-sis9952k	23	15	quinolinic	quinolinic	NNP
cord-299731-sis9952k	23	16	acid	acid	NNP
cord-299731-sis9952k	23	17	(	(	-LRB-
cord-299731-sis9952k	23	18	QA	QA	NNP
cord-299731-sis9952k	23	19	)	)	-RRB-
cord-299731-sis9952k	23	20	,	,	,
cord-299731-sis9952k	23	21	Preiss	Preiss	NNP
cord-299731-sis9952k	23	22	-	-	HYPH
cord-299731-sis9952k	23	23	Handler	Handler	NNP
cord-299731-sis9952k	23	24	pathway	pathway	NN
cord-299731-sis9952k	23	25	from	from	IN
cord-299731-sis9952k	23	26	nicotinic	nicotinic	JJ
cord-299731-sis9952k	23	27	acid	acid	NN
cord-299731-sis9952k	23	28	(	(	-LRB-
cord-299731-sis9952k	23	29	NA	NA	NNP
cord-299731-sis9952k	23	30	)	)	-RRB-
cord-299731-sis9952k	23	31	via	via	IN
cord-299731-sis9952k	23	32	nicotinic	nicotinic	JJ
cord-299731-sis9952k	23	33	acid	acid	NN
cord-299731-sis9952k	23	34	adenine	adenine	NN
cord-299731-sis9952k	23	35	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	23	36	(	(	-LRB-
cord-299731-sis9952k	23	37	NAAD	NAAD	NNP
cord-299731-sis9952k	23	38	)	)	-RRB-
cord-299731-sis9952k	23	39	and	and	CC
cord-299731-sis9952k	23	40	NAD	NAD	NNP
cord-299731-sis9952k	23	41	synthetase	synthetase	NN
cord-299731-sis9952k	23	42	(	(	-LRB-
cord-299731-sis9952k	23	43	NADS	NADS	NNP
cord-299731-sis9952k	23	44	)	)	-RRB-
cord-299731-sis9952k	23	45	,	,	,
cord-299731-sis9952k	23	46	and	and	CC
cord-299731-sis9952k	23	47	"	"	``
cord-299731-sis9952k	23	48	salvage	salvage	NN
cord-299731-sis9952k	23	49	pathways	pathway	NNS
cord-299731-sis9952k	23	50	"	"	''
cord-299731-sis9952k	23	51	from	from	IN
cord-299731-sis9952k	23	52	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	23	53	riboside	riboside	NN
cord-299731-sis9952k	23	54	(	(	-LRB-
cord-299731-sis9952k	23	55	NR	NR	NNP
cord-299731-sis9952k	23	56	)	)	-RRB-
cord-299731-sis9952k	23	57	and	and	CC
cord-299731-sis9952k	23	58	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	23	59	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	23	60	(	(	-LRB-
cord-299731-sis9952k	23	61	NMN	NMN	NNP
cord-299731-sis9952k	23	62	)	)	-RRB-
cord-299731-sis9952k	24	1	via	via	IN
cord-299731-sis9952k	24	2	purine	purine	NN
cord-299731-sis9952k	24	3	nucleoside	nucleoside	NN
cord-299731-sis9952k	24	4	phosphorylase	phosphorylase	NN
cord-299731-sis9952k	24	5	(	(	-LRB-
cord-299731-sis9952k	24	6	NP	NP	NNP
cord-299731-sis9952k	24	7	)	)	-RRB-
cord-299731-sis9952k	24	8	and	and	CC
cord-299731-sis9952k	24	9	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	24	10	phosphoribosyltransferase	phosphoribosyltransferase	NN
cord-299731-sis9952k	24	11	(	(	-LRB-
cord-299731-sis9952k	24	12	NAMPT	NAMPT	NNP
cord-299731-sis9952k	24	13	)	)	-RRB-
cord-299731-sis9952k	24	14	enzymes	enzyme	NNS
cord-299731-sis9952k	24	15	or	or	CC
cord-299731-sis9952k	24	16	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	24	17	ribose	ribose	NN
cord-299731-sis9952k	24	18	kinases	kinase	NNS
cord-299731-sis9952k	24	19	(	(	-LRB-
cord-299731-sis9952k	24	20	NRK	NRK	NNP
cord-299731-sis9952k	24	21	)	)	-RRB-
cord-299731-sis9952k	24	22	and	and	CC
cord-299731-sis9952k	24	23	NMN	NMN	NNP
cord-299731-sis9952k	24	24	/	/	SYM
cord-299731-sis9952k	24	25	NaMN	NaMN	NNP
cord-299731-sis9952k	24	26	adenylyltransferases	adenylyltransferase	NNS
cord-299731-sis9952k	24	27	(	(	-LRB-
cord-299731-sis9952k	24	28	NMNAT	NMNAT	NNP
cord-299731-sis9952k	24	29	)	)	-RRB-
cord-299731-sis9952k	24	30	,	,	,
cord-299731-sis9952k	24	31	respectively	respectively	RB
cord-299731-sis9952k	24	32	.	.	.
cord-299731-sis9952k	25	1	The	the	DT
cord-299731-sis9952k	25	2	importance	importance	NN
cord-299731-sis9952k	25	3	of	of	IN
cord-299731-sis9952k	25	4	NAD	NAD	NNP
cord-299731-sis9952k	25	5	+	+	CC
cord-299731-sis9952k	25	6	is	be	VBZ
cord-299731-sis9952k	25	7	reflected	reflect	VBN
cord-299731-sis9952k	25	8	through	through	IN
cord-299731-sis9952k	25	9	the	the	DT
cord-299731-sis9952k	25	10	activity	activity	NN
cord-299731-sis9952k	25	11	of	of	IN
cord-299731-sis9952k	25	12	NAD	NAD	NNP
cord-299731-sis9952k	25	13	+	+	CC
cord-299731-sis9952k	25	14	-depleting	-depleting	NN
cord-299731-sis9952k	25	15	enzymes	enzyme	NNS
cord-299731-sis9952k	25	16	,	,	,
cord-299731-sis9952k	25	17	the	the	DT
cord-299731-sis9952k	25	18	mediators	mediator	NNS
cord-299731-sis9952k	25	19	of	of	IN
cord-299731-sis9952k	25	20	aging	aging	NN
cord-299731-sis9952k	25	21	,	,	,
cord-299731-sis9952k	25	22	which	which	WDT
cord-299731-sis9952k	25	23	are	be	VBP
cord-299731-sis9952k	25	24	mostly	mostly	RB
cord-299731-sis9952k	25	25	induced	induce	VBN
cord-299731-sis9952k	25	26	by	by	IN
cord-299731-sis9952k	25	27	stress	stress	NN
cord-299731-sis9952k	25	28	factors	factor	NNS
cord-299731-sis9952k	25	29	,	,	,
cord-299731-sis9952k	25	30	such	such	JJ
cord-299731-sis9952k	25	31	as	as	IN
cord-299731-sis9952k	25	32	DNA	dna	NN
cord-299731-sis9952k	25	33	damage	damage	NN
cord-299731-sis9952k	25	34	,	,	,
cord-299731-sis9952k	25	35	oxidative	oxidative	JJ
cord-299731-sis9952k	25	36	stress	stress	NN
cord-299731-sis9952k	25	37	,	,	,
cord-299731-sis9952k	25	38	and	and	CC
cord-299731-sis9952k	25	39	inflammation	inflammation	NN
cord-299731-sis9952k	25	40	.	.	.
cord-299731-sis9952k	26	1	The	the	DT
cord-299731-sis9952k	26	2	major	major	JJ
cord-299731-sis9952k	26	3	downstream	downstream	JJ
cord-299731-sis9952k	26	4	mediators	mediator	NNS
cord-299731-sis9952k	26	5	are	be	VBP
cord-299731-sis9952k	26	6	sirtuins	sirtuin	NNS
cord-299731-sis9952k	26	7	,	,	,
cord-299731-sis9952k	26	8	the	the	DT
cord-299731-sis9952k	26	9	NAD	NAD	NNP
cord-299731-sis9952k	26	10	+	+	CC
cord-299731-sis9952k	26	11	-dependent	-dependent	NNP
cord-299731-sis9952k	26	12	deacetylases	deacetylases	NNP
cord-299731-sis9952k	26	13	/	/	SYM
cord-299731-sis9952k	26	14	deacylases	deacylase	NNS
cord-299731-sis9952k	26	15	.	.	.
cord-299731-sis9952k	27	1	Sirtuins	sirtuin	NNS
cord-299731-sis9952k	27	2	are	be	VBP
cord-299731-sis9952k	27	3	conserved	conserve	VBN
cord-299731-sis9952k	27	4	regulators	regulator	NNS
cord-299731-sis9952k	27	5	of	of	IN
cord-299731-sis9952k	27	6	aging	age	VBG
cord-299731-sis9952k	27	7	and	and	CC
cord-299731-sis9952k	27	8	longevity	longevity	NN
cord-299731-sis9952k	27	9	in	in	IN
cord-299731-sis9952k	27	10	diverse	diverse	JJ
cord-299731-sis9952k	27	11	organisms	organism	NNS
cord-299731-sis9952k	27	12	,	,	,
cord-299731-sis9952k	27	13	and	and	CC
cord-299731-sis9952k	27	14	regarded	regard	VBD
cord-299731-sis9952k	27	15	as	as	IN
cord-299731-sis9952k	27	16	the	the	DT
cord-299731-sis9952k	27	17	master	master	NN
cord-299731-sis9952k	27	18	switches	switch	VBZ
cord-299731-sis9952k	27	19	of	of	IN
cord-299731-sis9952k	27	20	metabolism	metabolism	NN
cord-299731-sis9952k	27	21	[	[	-LRB-
cord-299731-sis9952k	27	22	22	22	CD
cord-299731-sis9952k	27	23	]	]	-RRB-
cord-299731-sis9952k	27	24	due	due	IN
cord-299731-sis9952k	27	25	to	to	IN
cord-299731-sis9952k	27	26	their	-PRON-	PRP$
cord-299731-sis9952k	27	27	numerous	numerous	JJ
cord-299731-sis9952k	27	28	regulatory	regulatory	JJ
cord-299731-sis9952k	27	29	functions	function	NNS
cord-299731-sis9952k	27	30	in	in	IN
cord-299731-sis9952k	27	31	metabolism	metabolism	NN
cord-299731-sis9952k	27	32	,	,	,
cord-299731-sis9952k	27	33	DNA	dna	NN
cord-299731-sis9952k	27	34	repair	repair	NN
cord-299731-sis9952k	27	35	,	,	,
cord-299731-sis9952k	27	36	stress	stress	NN
cord-299731-sis9952k	27	37	response	response	NN
cord-299731-sis9952k	27	38	,	,	,
cord-299731-sis9952k	27	39	chromatin	chromatin	NN
cord-299731-sis9952k	27	40	remodeling	remodeling	NN
cord-299731-sis9952k	27	41	and	and	CC
cord-299731-sis9952k	27	42	circadian	circadian	NN
cord-299731-sis9952k	27	43	rhythm	rhythm	NN
cord-299731-sis9952k	27	44	.	.	.
cord-299731-sis9952k	28	1	(	(	-LRB-
cord-299731-sis9952k	28	2	Table	table	NN
cord-299731-sis9952k	28	3	1	1	CD
cord-299731-sis9952k	28	4	)	)	-RRB-
cord-299731-sis9952k	28	5	[	[	-LRB-
cord-299731-sis9952k	28	6	2	2	CD
cord-299731-sis9952k	28	7	,	,	,
cord-299731-sis9952k	28	8	23	23	CD
cord-299731-sis9952k	28	9	]	]	-RRB-
cord-299731-sis9952k	28	10	.	.	.
cord-299731-sis9952k	29	1	Together	together	RB
cord-299731-sis9952k	29	2	with	with	IN
cord-299731-sis9952k	29	3	sirtuins	sirtuin	NNS
cord-299731-sis9952k	29	4	,	,	,
cord-299731-sis9952k	29	5	PARPs	PARPs	NNPS
cord-299731-sis9952k	29	6	use	use	VBP
cord-299731-sis9952k	29	7	NAD	NAD	NNP
cord-299731-sis9952k	29	8	+	+	CC
cord-299731-sis9952k	29	9	to	to	TO
cord-299731-sis9952k	29	10	produce	produce	VB
cord-299731-sis9952k	29	11	a	a	DT
cord-299731-sis9952k	29	12	chain	chain	NN
cord-299731-sis9952k	29	13	of	of	IN
cord-299731-sis9952k	29	14	ADP	ADP	NNP
cord-299731-sis9952k	29	15	-	-	HYPH
cord-299731-sis9952k	29	16	ribose	ribose	NN
cord-299731-sis9952k	29	17	(	(	-LRB-
cord-299731-sis9952k	29	18	ADPR	ADPR	NNP
cord-299731-sis9952k	29	19	)	)	-RRB-
cord-299731-sis9952k	29	20	molecules	molecule	NNS
cord-299731-sis9952k	29	21	.	.	.
cord-299731-sis9952k	30	1	PARP1	PARP1	NNP
cord-299731-sis9952k	30	2	and	and	CC
cord-299731-sis9952k	30	3	PARP2	PARP2	VBD
cord-299731-sis9952k	30	4	respond	respond	VBP
cord-299731-sis9952k	30	5	to	to	IN
cord-299731-sis9952k	30	6	DNA	dna	NN
cord-299731-sis9952k	30	7	breaks	break	NNS
cord-299731-sis9952k	30	8	in	in	IN
cord-299731-sis9952k	30	9	the	the	DT
cord-299731-sis9952k	30	10	nucleus	nucleus	NN
cord-299731-sis9952k	30	11	and	and	CC
cord-299731-sis9952k	30	12	facilitate	facilitate	VB
cord-299731-sis9952k	30	13	the	the	DT
cord-299731-sis9952k	30	14	process	process	NN
cord-299731-sis9952k	30	15	of	of	IN
cord-299731-sis9952k	30	16	DNA	dna	NN
cord-299731-sis9952k	30	17	repair	repair	NN
cord-299731-sis9952k	30	18	[	[	-LRB-
cord-299731-sis9952k	30	19	23	23	CD
cord-299731-sis9952k	30	20	]	]	-RRB-
cord-299731-sis9952k	30	21	.	.	.
cord-299731-sis9952k	31	1	As	as	IN
cord-299731-sis9952k	31	2	DNA	dna	NN
cord-299731-sis9952k	31	3	damage	damage	NN
cord-299731-sis9952k	31	4	accumulates	accumulate	VBZ
cord-299731-sis9952k	31	5	over	over	IN
cord-299731-sis9952k	31	6	time	time	NN
cord-299731-sis9952k	31	7	,	,	,
cord-299731-sis9952k	31	8	the	the	DT
cord-299731-sis9952k	31	9	activation	activation	NN
cord-299731-sis9952k	31	10	of	of	IN
cord-299731-sis9952k	31	11	PARPs	PARPs	NNPS
cord-299731-sis9952k	31	12	increase	increase	NN
cord-299731-sis9952k	31	13	,	,	,
cord-299731-sis9952k	31	14	which	which	WDT
cord-299731-sis9952k	31	15	in	in	IN
cord-299731-sis9952k	31	16	turn	turn	NN
cord-299731-sis9952k	31	17	,	,	,
cord-299731-sis9952k	31	18	lowers	lower	VBZ
cord-299731-sis9952k	31	19	the	the	DT
cord-299731-sis9952k	31	20	activity	activity	NN
cord-299731-sis9952k	31	21	of	of	IN
cord-299731-sis9952k	31	22	SIRT1	sirt1	NN
cord-299731-sis9952k	31	23	due	due	IN
cord-299731-sis9952k	31	24	to	to	IN
cord-299731-sis9952k	31	25	both	both	DT
cord-299731-sis9952k	31	26	substrate	substrate	NN
cord-299731-sis9952k	31	27	competition	competition	NN
cord-299731-sis9952k	31	28	and	and	CC
cord-299731-sis9952k	31	29	PARP2	parp2	NN
cord-299731-sis9952k	31	30	s	s	POS
cord-299731-sis9952k	31	31	ability	ability	NN
cord-299731-sis9952k	31	32	to	to	TO
cord-299731-sis9952k	31	33	bind	bind	VB
cord-299731-sis9952k	31	34	to	to	IN
cord-299731-sis9952k	31	35	the	the	DT
cord-299731-sis9952k	31	36	promoter	promoter	NN
cord-299731-sis9952k	31	37	of	of	IN
cord-299731-sis9952k	31	38	Sirt1	Sirt1	NNP
cord-299731-sis9952k	31	39	and	and	CC
cord-299731-sis9952k	31	40	repress	repress	VB
cord-299731-sis9952k	31	41	its	-PRON-	PRP$
cord-299731-sis9952k	31	42	expression	expression	NN
cord-299731-sis9952k	31	43	[	[	-LRB-
cord-299731-sis9952k	31	44	24	24	CD
cord-299731-sis9952k	31	45	]	]	-RRB-
cord-299731-sis9952k	31	46	.	.	.
cord-299731-sis9952k	32	1	Furthermore	furthermore	RB
cord-299731-sis9952k	32	2	,	,	,
cord-299731-sis9952k	32	3	the	the	DT
cord-299731-sis9952k	32	4	content	content	NN
cord-299731-sis9952k	32	5	of	of	IN
cord-299731-sis9952k	32	6	the	the	DT
cord-299731-sis9952k	32	7	primary	primary	JJ
cord-299731-sis9952k	32	8	NADase	NADase	NNP
cord-299731-sis9952k	32	9	in	in	IN
cord-299731-sis9952k	32	10	mammals	mammal	NNS
cord-299731-sis9952k	32	11	,	,	,
cord-299731-sis9952k	32	12	CD38	CD38	NNP
cord-299731-sis9952k	32	13	,	,	,
cord-299731-sis9952k	32	14	increases	increase	VBZ
cord-299731-sis9952k	32	15	with	with	IN
cord-299731-sis9952k	32	16	age	age	NN
cord-299731-sis9952k	32	17	.	.	.
cord-299731-sis9952k	33	1	This	this	DT
cord-299731-sis9952k	33	2	enzyme	enzyme	NN
cord-299731-sis9952k	33	3	uses	use	VBZ
cord-299731-sis9952k	33	4	NAD	NAD	NNP
cord-299731-sis9952k	33	5	+	+	CC
cord-299731-sis9952k	33	6	to	to	TO
cord-299731-sis9952k	33	7	produce	produce	VB
cord-299731-sis9952k	33	8	and	and	CC
cord-299731-sis9952k	33	9	hydrolyze	hydrolyze	VB
cord-299731-sis9952k	33	10	the	the	DT
cord-299731-sis9952k	33	11	Ca	Ca	NNP
cord-299731-sis9952k	33	12	2	2	CD
cord-299731-sis9952k	33	13	+	+	SYM
cord-299731-sis9952k	33	14	-mobilizing	-mobilize	VBG
cord-299731-sis9952k	33	15	second	second	JJ
cord-299731-sis9952k	33	16	messenger	messenger	NN
cord-299731-sis9952k	33	17	,	,	,
cord-299731-sis9952k	33	18	cADP	cadp	JJ
cord-299731-sis9952k	33	19	-	-	HYPH
cord-299731-sis9952k	33	20	ribose	ribose	NN
cord-299731-sis9952k	33	21	[	[	-LRB-
cord-299731-sis9952k	33	22	25	25	CD
cord-299731-sis9952k	33	23	]	]	-RRB-
cord-299731-sis9952k	33	24	[	[	-LRB-
cord-299731-sis9952k	33	25	26	26	CD
cord-299731-sis9952k	33	26	]	]	-RRB-
cord-299731-sis9952k	33	27	[	[	-LRB-
cord-299731-sis9952k	33	28	27	27	CD
cord-299731-sis9952k	33	29	]	]	-RRB-
cord-299731-sis9952k	33	30	.	.	.
cord-299731-sis9952k	34	1	CD38	CD38	NNP
cord-299731-sis9952k	34	2	can	can	MD
cord-299731-sis9952k	34	3	also	also	RB
cord-299731-sis9952k	34	4	degrade	degrade	VB
cord-299731-sis9952k	34	5	the	the	DT
cord-299731-sis9952k	34	6	NAD	NAD	NNP
cord-299731-sis9952k	34	7	+	+	CC
cord-299731-sis9952k	34	8	intermediates	intermediate	NNS
cord-299731-sis9952k	34	9	,	,	,
cord-299731-sis9952k	34	10	NR	NR	NNP
cord-299731-sis9952k	34	11	and	and	CC
cord-299731-sis9952k	34	12	NMN	NMN	NNP
cord-299731-sis9952k	34	13	[	[	-LRB-
cord-299731-sis9952k	34	14	28	28	CD
cord-299731-sis9952k	34	15	,	,	,
cord-299731-sis9952k	34	16	29	29	CD
cord-299731-sis9952k	34	17	]	]	-RRB-
cord-299731-sis9952k	34	18	,	,	,
cord-299731-sis9952k	34	19	which	which	WDT
cord-299731-sis9952k	34	20	further	further	RB
cord-299731-sis9952k	34	21	decreases	decrease	VBZ
cord-299731-sis9952k	34	22	the	the	DT
cord-299731-sis9952k	34	23	content	content	NN
cord-299731-sis9952k	34	24	of	of	IN
cord-299731-sis9952k	34	25	NAD	NAD	NNP
cord-299731-sis9952k	34	26	+	+	CC
cord-299731-sis9952k	34	27	[	[	-LRB-
cord-299731-sis9952k	34	28	30	30	CD
cord-299731-sis9952k	34	29	]	]	-RRB-
cord-299731-sis9952k	34	30	.	.	.
cord-299731-sis9952k	35	1	The	the	DT
cord-299731-sis9952k	35	2	effect	effect	NN
cord-299731-sis9952k	35	3	of	of	IN
cord-299731-sis9952k	35	4	CD38	CD38	NNP
cord-299731-sis9952k	35	5	on	on	IN
cord-299731-sis9952k	35	6	NAD	NAD	NNP
cord-299731-sis9952k	35	7	+	+	CC
cord-299731-sis9952k	35	8	content	content	NN
cord-299731-sis9952k	35	9	was	be	VBD
cord-299731-sis9952k	35	10	demonstrated	demonstrate	VBN
cord-299731-sis9952k	35	11	in	in	IN
cord-299731-sis9952k	35	12	CD38-deficient	cd38-deficient	CD
cord-299731-sis9952k	35	13	mice	mouse	NNS
cord-299731-sis9952k	35	14	,	,	,
cord-299731-sis9952k	35	15	whose	whose	WP$
cord-299731-sis9952k	35	16	NAD	NAD	NNP
cord-299731-sis9952k	35	17	+	+	CC
cord-299731-sis9952k	35	18	levels	level	NNS
cord-299731-sis9952k	35	19	remain	remain	VBP
cord-299731-sis9952k	35	20	high	high	JJ
cord-299731-sis9952k	35	21	.	.	.
cord-299731-sis9952k	36	1	This	this	DT
cord-299731-sis9952k	36	2	preserves	preserve	VBZ
cord-299731-sis9952k	36	3	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	36	4	respiration	respiration	NN
cord-299731-sis9952k	36	5	and	and	CC
cord-299731-sis9952k	36	6	metabolic	metabolic	JJ
cord-299731-sis9952k	36	7	function	function	NN
cord-299731-sis9952k	36	8	with	with	IN
cord-299731-sis9952k	36	9	age	age	NN
cord-299731-sis9952k	36	10	[	[	-LRB-
cord-299731-sis9952k	36	11	31	31	CD
cord-299731-sis9952k	36	12	]	]	-RRB-
cord-299731-sis9952k	36	13	.	.	.
cord-299731-sis9952k	37	1	Moreover	moreover	RB
cord-299731-sis9952k	37	2	,	,	,
cord-299731-sis9952k	37	3	the	the	DT
cord-299731-sis9952k	37	4	inhibition	inhibition	NN
cord-299731-sis9952k	37	5	of	of	IN
cord-299731-sis9952k	37	6	CD38	CD38	NNP
cord-299731-sis9952k	37	7	can	can	MD
cord-299731-sis9952k	37	8	increase	increase	VB
cord-299731-sis9952k	37	9	NAD	NAD	NNP
cord-299731-sis9952k	37	10	+	+	CC
cord-299731-sis9952k	37	11	levels	level	NNS
cord-299731-sis9952k	37	12	and	and	CC
cord-299731-sis9952k	37	13	improve	improve	VB
cord-299731-sis9952k	37	14	glucose	glucose	NN
cord-299731-sis9952k	37	15	and	and	CC
cord-299731-sis9952k	37	16	lipid	lipid	NN
cord-299731-sis9952k	37	17	metabolism	metabolism	NN
cord-299731-sis9952k	37	18	[	[	-LRB-
cord-299731-sis9952k	37	19	32	32	CD
cord-299731-sis9952k	37	20	]	]	-RRB-
cord-299731-sis9952k	37	21	.	.	.
cord-299731-sis9952k	38	1	Apart	apart	RB
cord-299731-sis9952k	38	2	from	from	IN
cord-299731-sis9952k	38	3	the	the	DT
cord-299731-sis9952k	38	4	ectoenzymes	ectoenzymes	JJ
cord-299731-sis9952k	38	5	CD38	CD38	NNP
cord-299731-sis9952k	38	6	and	and	CC
cord-299731-sis9952k	38	7	CD157	CD157	NNP
cord-299731-sis9952k	38	8	,	,	,
cord-299731-sis9952k	38	9	SARM1	SARM1	NNP
cord-299731-sis9952k	38	10	(	(	-LRB-
cord-299731-sis9952k	38	11	sterile	sterile	JJ
cord-299731-sis9952k	38	12	alpha	alpha	NN
cord-299731-sis9952k	38	13	and	and	CC
cord-299731-sis9952k	38	14	Toll	Toll	NNP
cord-299731-sis9952k	38	15	/	/	SYM
cord-299731-sis9952k	38	16	interleukin-1	interleukin-1	NN
cord-299731-sis9952k	38	17	receptor	receptor	NN
cord-299731-sis9952k	38	18	motif	motif	NN
cord-299731-sis9952k	38	19	-	-	:
cord-299731-sis9952k	38	20	containing	contain	VBG
cord-299731-sis9952k	38	21	1	1	CD
cord-299731-sis9952k	38	22	)	)	-RRB-
cord-299731-sis9952k	38	23	is	be	VBZ
cord-299731-sis9952k	38	24	an	an	DT
cord-299731-sis9952k	38	25	additional	additional	JJ
cord-299731-sis9952k	38	26	NAD	NAD	NNP
cord-299731-sis9952k	38	27	+	+	CC
cord-299731-sis9952k	38	28	-depleting	-depleting	NN
cord-299731-sis9952k	38	29	enzyme	enzyme	NN
cord-299731-sis9952k	38	30	that	that	WDT
cord-299731-sis9952k	38	31	uses	use	VBZ
cord-299731-sis9952k	38	32	NAD	NAD	NNP
cord-299731-sis9952k	38	33	+	+	CC
cord-299731-sis9952k	38	34	to	to	TO
cord-299731-sis9952k	38	35	promote	promote	VB
cord-299731-sis9952k	38	36	axonal	axonal	JJ
cord-299731-sis9952k	38	37	degeneration	degeneration	NN
cord-299731-sis9952k	38	38	after	after	IN
cord-299731-sis9952k	38	39	injury	injury	NN
cord-299731-sis9952k	38	40	and	and	CC
cord-299731-sis9952k	38	41	thereby	thereby	RB
cord-299731-sis9952k	38	42	decreases	decrease	VBZ
cord-299731-sis9952k	38	43	its	-PRON-	PRP$
cord-299731-sis9952k	38	44	overall	overall	JJ
cord-299731-sis9952k	38	45	content	content	NN
cord-299731-sis9952k	38	46	[	[	-LRB-
cord-299731-sis9952k	38	47	33	33	CD
cord-299731-sis9952k	38	48	]	]	-RRB-
cord-299731-sis9952k	38	49	.	.	.
cord-299731-sis9952k	39	1	Nutrients	nutrient	NNS
cord-299731-sis9952k	39	2	2020	2020	CD
cord-299731-sis9952k	39	3	,	,	,
cord-299731-sis9952k	39	4	12	12	CD
cord-299731-sis9952k	39	5	,	,	,
cord-299731-sis9952k	39	6	x	x	NN
cord-299731-sis9952k	39	7	FOR	for	IN
cord-299731-sis9952k	39	8	PEER	PEER	NNP
cord-299731-sis9952k	39	9	REVIEW	REVIEW	NNP
cord-299731-sis9952k	39	10	3	3	CD
cord-299731-sis9952k	39	11	of	of	IN
cord-299731-sis9952k	39	12	22	22	CD
cord-299731-sis9952k	39	13	Figure	figure	NN
cord-299731-sis9952k	39	14	2	2	CD
cord-299731-sis9952k	39	15	.	.	.
cord-299731-sis9952k	40	1	Activation	activation	NN
cord-299731-sis9952k	40	2	of	of	IN
cord-299731-sis9952k	40	3	the	the	DT
cord-299731-sis9952k	40	4	NMRK2	NMRK2	NNP
cord-299731-sis9952k	40	5	pathway	pathway	NN
cord-299731-sis9952k	40	6	represent	represent	VBP
cord-299731-sis9952k	40	7	a	a	DT
cord-299731-sis9952k	40	8	common	common	JJ
cord-299731-sis9952k	40	9	adaptive	adaptive	JJ
cord-299731-sis9952k	40	10	mechanism	mechanism	NN
cord-299731-sis9952k	40	11	in	in	IN
cord-299731-sis9952k	40	12	the	the	DT
cord-299731-sis9952k	40	13	failing	fail	VBG
cord-299731-sis9952k	40	14	heart	heart	NN
cord-299731-sis9952k	40	15	where	where	WRB
cord-299731-sis9952k	40	16	NAD	NAD	NNP
cord-299731-sis9952k	40	17	+	+	CC
cord-299731-sis9952k	40	18	levels	level	NNS
cord-299731-sis9952k	40	19	are	be	VBP
cord-299731-sis9952k	40	20	low	low	JJ
cord-299731-sis9952k	40	21	.	.	.
cord-299731-sis9952k	41	1	NAD	NAD	NNP
cord-299731-sis9952k	41	2	+	+	CC
cord-299731-sis9952k	41	3	synthesis	synthesis	NN
cord-299731-sis9952k	41	4	from	from	IN
cord-299731-sis9952k	41	5	NR	NR	NNP
cord-299731-sis9952k	41	6	through	through	IN
cord-299731-sis9952k	41	7	the	the	DT
cord-299731-sis9952k	41	8	NMRK2	NMRK2	NNP
cord-299731-sis9952k	41	9	pathway	pathway	NN
cord-299731-sis9952k	41	10	may	may	MD
cord-299731-sis9952k	41	11	be	be	VB
cord-299731-sis9952k	41	12	favored	favor	VBN
cord-299731-sis9952k	41	13	,	,	,
cord-299731-sis9952k	41	14	as	as	IN
cord-299731-sis9952k	41	15	the	the	DT
cord-299731-sis9952k	41	16	NMN	NMN	NNP
cord-299731-sis9952k	41	17	synthesis	synthesis	NN
cord-299731-sis9952k	41	18	from	from	IN
cord-299731-sis9952k	41	19	NR	NR	NNP
cord-299731-sis9952k	41	20	by	by	IN
cord-299731-sis9952k	41	21	NMRK	NMRK	NNP
cord-299731-sis9952k	41	22	enzymes	enzyme	NNS
cord-299731-sis9952k	41	23	requires	require	VBZ
cord-299731-sis9952k	41	24	only	only	RB
cord-299731-sis9952k	41	25	one	one	CD
cord-299731-sis9952k	41	26	ATP	ATP	NNP
cord-299731-sis9952k	41	27	molecule	molecule	NN
cord-299731-sis9952k	41	28	while	while	IN
cord-299731-sis9952k	41	29	synthesis	synthesis	NN
cord-299731-sis9952k	41	30	from	from	IN
cord-299731-sis9952k	41	31	NAM	NAM	NNP
cord-299731-sis9952k	41	32	by	by	IN
cord-299731-sis9952k	41	33	NAMPT	NAMPT	NNP
cord-299731-sis9952k	41	34	requires	require	VBZ
cord-299731-sis9952k	41	35	at	at	IN
cord-299731-sis9952k	41	36	least	least	RBS
cord-299731-sis9952k	41	37	three	three	CD
cord-299731-sis9952k	41	38	ATP	ATP	NNP
cord-299731-sis9952k	41	39	equivalents	equivalent	NNS
cord-299731-sis9952k	41	40	.	.	.
cord-299731-sis9952k	42	1	The	the	DT
cord-299731-sis9952k	42	2	importance	importance	NN
cord-299731-sis9952k	42	3	of	of	IN
cord-299731-sis9952k	42	4	NAD	NAD	NNP
cord-299731-sis9952k	42	5	+	+	CC
cord-299731-sis9952k	42	6	is	be	VBZ
cord-299731-sis9952k	42	7	reflected	reflect	VBN
cord-299731-sis9952k	42	8	through	through	IN
cord-299731-sis9952k	42	9	the	the	DT
cord-299731-sis9952k	42	10	activity	activity	NN
cord-299731-sis9952k	42	11	of	of	IN
cord-299731-sis9952k	42	12	NAD	NAD	NNP
cord-299731-sis9952k	42	13	+	+	CC
cord-299731-sis9952k	42	14	-depleting	-depleting	NN
cord-299731-sis9952k	42	15	enzymes	enzyme	NNS
cord-299731-sis9952k	42	16	,	,	,
cord-299731-sis9952k	42	17	the	the	DT
cord-299731-sis9952k	42	18	mediators	mediator	NNS
cord-299731-sis9952k	42	19	of	of	IN
cord-299731-sis9952k	42	20	aging	aging	NN
cord-299731-sis9952k	42	21	,	,	,
cord-299731-sis9952k	42	22	which	which	WDT
cord-299731-sis9952k	42	23	are	be	VBP
cord-299731-sis9952k	42	24	mostly	mostly	RB
cord-299731-sis9952k	42	25	induced	induce	VBN
cord-299731-sis9952k	42	26	by	by	IN
cord-299731-sis9952k	42	27	stress	stress	NN
cord-299731-sis9952k	42	28	factors	factor	NNS
cord-299731-sis9952k	42	29	,	,	,
cord-299731-sis9952k	42	30	such	such	JJ
cord-299731-sis9952k	42	31	as	as	IN
cord-299731-sis9952k	42	32	DNA	dna	NN
cord-299731-sis9952k	42	33	damage	damage	NN
cord-299731-sis9952k	42	34	,	,	,
cord-299731-sis9952k	42	35	oxidative	oxidative	JJ
cord-299731-sis9952k	42	36	stress	stress	NN
cord-299731-sis9952k	42	37	,	,	,
cord-299731-sis9952k	42	38	and	and	CC
cord-299731-sis9952k	42	39	inflammation	inflammation	NN
cord-299731-sis9952k	42	40	.	.	.
cord-299731-sis9952k	43	1	The	the	DT
cord-299731-sis9952k	43	2	major	major	JJ
cord-299731-sis9952k	43	3	downstream	downstream	JJ
cord-299731-sis9952k	43	4	mediators	mediator	NNS
cord-299731-sis9952k	43	5	are	be	VBP
cord-299731-sis9952k	43	6	sirtuins	sirtuin	NNS
cord-299731-sis9952k	43	7	,	,	,
cord-299731-sis9952k	43	8	the	the	DT
cord-299731-sis9952k	43	9	NAD	NAD	NNP
cord-299731-sis9952k	43	10	+	+	CC
cord-299731-sis9952k	43	11	-dependent	-dependent	NNP
cord-299731-sis9952k	43	12	deacetylases	deacetylases	NNP
cord-299731-sis9952k	43	13	/	/	SYM
cord-299731-sis9952k	43	14	deacylases	deacylase	NNS
cord-299731-sis9952k	43	15	.	.	.
cord-299731-sis9952k	44	1	Sirtuins	sirtuin	NNS
cord-299731-sis9952k	44	2	are	be	VBP
cord-299731-sis9952k	44	3	conserved	conserve	VBN
cord-299731-sis9952k	44	4	regulators	regulator	NNS
cord-299731-sis9952k	44	5	of	of	IN
cord-299731-sis9952k	44	6	aging	age	VBG
cord-299731-sis9952k	44	7	and	and	CC
cord-299731-sis9952k	44	8	longevity	longevity	NN
cord-299731-sis9952k	44	9	in	in	IN
cord-299731-sis9952k	44	10	diverse	diverse	JJ
cord-299731-sis9952k	44	11	organisms	organism	NNS
cord-299731-sis9952k	44	12	,	,	,
cord-299731-sis9952k	44	13	and	and	CC
cord-299731-sis9952k	44	14	regarded	regard	VBD
cord-299731-sis9952k	44	15	as	as	IN
cord-299731-sis9952k	44	16	the	the	DT
cord-299731-sis9952k	44	17	master	master	NN
cord-299731-sis9952k	44	18	switches	switch	VBZ
cord-299731-sis9952k	44	19	of	of	IN
cord-299731-sis9952k	44	20	metabolism	metabolism	NN
cord-299731-sis9952k	44	21	[	[	-LRB-
cord-299731-sis9952k	44	22	22	22	CD
cord-299731-sis9952k	44	23	]	]	-RRB-
cord-299731-sis9952k	44	24	due	due	IN
cord-299731-sis9952k	44	25	to	to	IN
cord-299731-sis9952k	44	26	their	-PRON-	PRP$
cord-299731-sis9952k	44	27	numerous	numerous	JJ
cord-299731-sis9952k	44	28	regulatory	regulatory	JJ
cord-299731-sis9952k	44	29	functions	function	NNS
cord-299731-sis9952k	44	30	in	in	IN
cord-299731-sis9952k	44	31	metabolism	metabolism	NN
cord-299731-sis9952k	44	32	,	,	,
cord-299731-sis9952k	44	33	DNA	dna	NN
cord-299731-sis9952k	44	34	repair	repair	NN
cord-299731-sis9952k	44	35	,	,	,
cord-299731-sis9952k	44	36	stress	stress	NN
cord-299731-sis9952k	44	37	response	response	NN
cord-299731-sis9952k	44	38	,	,	,
cord-299731-sis9952k	44	39	chromatin	chromatin	NN
cord-299731-sis9952k	44	40	remodeling	remodeling	NN
cord-299731-sis9952k	44	41	and	and	CC
cord-299731-sis9952k	44	42	circadian	circadian	NN
cord-299731-sis9952k	44	43	rhythm	rhythm	NN
cord-299731-sis9952k	44	44	.	.	.
cord-299731-sis9952k	45	1	(	(	-LRB-
cord-299731-sis9952k	45	2	Table	table	NN
cord-299731-sis9952k	45	3	1	1	CD
cord-299731-sis9952k	45	4	)	)	-RRB-
cord-299731-sis9952k	45	5	[	[	-LRB-
cord-299731-sis9952k	45	6	2	2	CD
cord-299731-sis9952k	45	7	,	,	,
cord-299731-sis9952k	45	8	23	23	CD
cord-299731-sis9952k	45	9	]	]	-RRB-
cord-299731-sis9952k	45	10	.	.	.
cord-299731-sis9952k	46	1	Together	together	RB
cord-299731-sis9952k	46	2	with	with	IN
cord-299731-sis9952k	46	3	sirtuins	sirtuin	NNS
cord-299731-sis9952k	46	4	,	,	,
cord-299731-sis9952k	46	5	PARPs	PARPs	NNPS
cord-299731-sis9952k	46	6	use	use	VBP
cord-299731-sis9952k	46	7	NAD	NAD	NNP
cord-299731-sis9952k	46	8	+	+	CC
cord-299731-sis9952k	46	9	to	to	TO
cord-299731-sis9952k	46	10	produce	produce	VB
cord-299731-sis9952k	46	11	a	a	DT
cord-299731-sis9952k	46	12	chain	chain	NN
cord-299731-sis9952k	46	13	of	of	IN
cord-299731-sis9952k	46	14	ADP	ADP	NNP
cord-299731-sis9952k	46	15	-	-	HYPH
cord-299731-sis9952k	46	16	ribose	ribose	NN
cord-299731-sis9952k	46	17	(	(	-LRB-
cord-299731-sis9952k	46	18	ADPR	ADPR	NNP
cord-299731-sis9952k	46	19	)	)	-RRB-
cord-299731-sis9952k	46	20	molecules	molecule	NNS
cord-299731-sis9952k	46	21	.	.	.
cord-299731-sis9952k	47	1	PARP1	PARP1	NNP
cord-299731-sis9952k	47	2	and	and	CC
cord-299731-sis9952k	47	3	PARP2	PARP2	VBD
cord-299731-sis9952k	47	4	respond	respond	VBP
cord-299731-sis9952k	47	5	to	to	IN
cord-299731-sis9952k	47	6	DNA	dna	NN
cord-299731-sis9952k	47	7	breaks	break	NNS
cord-299731-sis9952k	47	8	in	in	IN
cord-299731-sis9952k	47	9	the	the	DT
cord-299731-sis9952k	47	10	nucleus	nucleus	NN
cord-299731-sis9952k	47	11	and	and	CC
cord-299731-sis9952k	47	12	facilitate	facilitate	VB
cord-299731-sis9952k	47	13	the	the	DT
cord-299731-sis9952k	47	14	process	process	NN
cord-299731-sis9952k	47	15	of	of	IN
cord-299731-sis9952k	47	16	DNA	dna	NN
cord-299731-sis9952k	47	17	repair	repair	NN
cord-299731-sis9952k	47	18	[	[	-LRB-
cord-299731-sis9952k	47	19	23	23	CD
cord-299731-sis9952k	47	20	]	]	-RRB-
cord-299731-sis9952k	47	21	.	.	.
cord-299731-sis9952k	48	1	As	as	IN
cord-299731-sis9952k	48	2	DNA	dna	NN
cord-299731-sis9952k	48	3	damage	damage	NN
cord-299731-sis9952k	48	4	accumulates	accumulate	VBZ
cord-299731-sis9952k	48	5	over	over	IN
cord-299731-sis9952k	48	6	time	time	NN
cord-299731-sis9952k	48	7	,	,	,
cord-299731-sis9952k	48	8	the	the	DT
cord-299731-sis9952k	48	9	activation	activation	NN
cord-299731-sis9952k	48	10	of	of	IN
cord-299731-sis9952k	48	11	PARPs	PARPs	NNPS
cord-299731-sis9952k	48	12	increase	increase	NN
cord-299731-sis9952k	48	13	,	,	,
cord-299731-sis9952k	48	14	which	which	WDT
cord-299731-sis9952k	48	15	in	in	IN
cord-299731-sis9952k	48	16	turn	turn	NN
cord-299731-sis9952k	48	17	,	,	,
cord-299731-sis9952k	48	18	lowers	lower	VBZ
cord-299731-sis9952k	48	19	the	the	DT
cord-299731-sis9952k	48	20	activity	activity	NN
cord-299731-sis9952k	48	21	of	of	IN
cord-299731-sis9952k	48	22	SIRT1	sirt1	NN
cord-299731-sis9952k	48	23	due	due	IN
cord-299731-sis9952k	48	24	to	to	IN
cord-299731-sis9952k	48	25	both	both	DT
cord-299731-sis9952k	48	26	substrate	substrate	NN
cord-299731-sis9952k	48	27	competition	competition	NN
cord-299731-sis9952k	48	28	and	and	CC
cord-299731-sis9952k	48	29	PARP2′s	parp2′s	JJ
cord-299731-sis9952k	48	30	ability	ability	NN
cord-299731-sis9952k	48	31	to	to	TO
cord-299731-sis9952k	48	32	bind	bind	VB
cord-299731-sis9952k	48	33	to	to	IN
cord-299731-sis9952k	48	34	the	the	DT
cord-299731-sis9952k	48	35	promoter	promoter	NN
cord-299731-sis9952k	48	36	of	of	IN
cord-299731-sis9952k	48	37	Sirt1	Sirt1	NNP
cord-299731-sis9952k	48	38	and	and	CC
cord-299731-sis9952k	48	39	repress	repress	VB
cord-299731-sis9952k	48	40	its	-PRON-	PRP$
cord-299731-sis9952k	48	41	expression	expression	NN
cord-299731-sis9952k	48	42	[	[	-LRB-
cord-299731-sis9952k	48	43	24	24	CD
cord-299731-sis9952k	48	44	]	]	-RRB-
cord-299731-sis9952k	48	45	.	.	.
cord-299731-sis9952k	49	1	Furthermore	furthermore	RB
cord-299731-sis9952k	49	2	,	,	,
cord-299731-sis9952k	49	3	the	the	DT
cord-299731-sis9952k	49	4	content	content	NN
cord-299731-sis9952k	49	5	of	of	IN
cord-299731-sis9952k	49	6	the	the	DT
cord-299731-sis9952k	49	7	primary	primary	JJ
cord-299731-sis9952k	49	8	NADase	NADase	NNP
cord-299731-sis9952k	49	9	in	in	IN
cord-299731-sis9952k	49	10	mammals	mammal	NNS
cord-299731-sis9952k	49	11	,	,	,
cord-299731-sis9952k	49	12	CD38	CD38	NNP
cord-299731-sis9952k	49	13	,	,	,
cord-299731-sis9952k	49	14	increases	increase	VBZ
cord-299731-sis9952k	49	15	with	with	IN
cord-299731-sis9952k	49	16	age	age	NN
cord-299731-sis9952k	49	17	.	.	.
cord-299731-sis9952k	50	1	This	this	DT
cord-299731-sis9952k	50	2	enzyme	enzyme	NN
cord-299731-sis9952k	50	3	uses	use	VBZ
cord-299731-sis9952k	50	4	NAD	NAD	NNP
cord-299731-sis9952k	50	5	+	+	CC
cord-299731-sis9952k	50	6	to	to	TO
cord-299731-sis9952k	50	7	produce	produce	VB
cord-299731-sis9952k	50	8	and	and	CC
cord-299731-sis9952k	50	9	hydrolyze	hydrolyze	VB
cord-299731-sis9952k	50	10	the	the	DT
cord-299731-sis9952k	50	11	Ca	Ca	NNP
cord-299731-sis9952k	50	12	2	2	CD
cord-299731-sis9952k	50	13	+	+	SYM
cord-299731-sis9952k	50	14	-mobilizing	-mobilize	VBG
cord-299731-sis9952k	50	15	second	second	JJ
cord-299731-sis9952k	50	16	messenger	messenger	NN
cord-299731-sis9952k	50	17	,	,	,
cord-299731-sis9952k	50	18	cADP	cadp	JJ
cord-299731-sis9952k	50	19	-	-	HYPH
cord-299731-sis9952k	50	20	ribose	ribose	NN
cord-299731-sis9952k	50	21	[	[	-LRB-
cord-299731-sis9952k	50	22	25	25	CD
cord-299731-sis9952k	50	23	]	]	-RRB-
cord-299731-sis9952k	50	24	[	[	-LRB-
cord-299731-sis9952k	50	25	26	26	CD
cord-299731-sis9952k	50	26	]	]	-RRB-
cord-299731-sis9952k	50	27	[	[	-LRB-
cord-299731-sis9952k	50	28	27	27	CD
cord-299731-sis9952k	50	29	]	]	-RRB-
cord-299731-sis9952k	50	30	.	.	.
cord-299731-sis9952k	51	1	CD38	CD38	NNP
cord-299731-sis9952k	51	2	can	can	MD
cord-299731-sis9952k	51	3	also	also	RB
cord-299731-sis9952k	51	4	degrade	degrade	VB
cord-299731-sis9952k	51	5	the	the	DT
cord-299731-sis9952k	51	6	NAD	NAD	NNP
cord-299731-sis9952k	51	7	+	+	CC
cord-299731-sis9952k	51	8	intermediates	intermediate	NNS
cord-299731-sis9952k	51	9	,	,	,
cord-299731-sis9952k	51	10	NR	NR	NNP
cord-299731-sis9952k	51	11	and	and	CC
cord-299731-sis9952k	51	12	NMN	NMN	NNP
cord-299731-sis9952k	51	13	[	[	-LRB-
cord-299731-sis9952k	51	14	28	28	CD
cord-299731-sis9952k	51	15	,	,	,
cord-299731-sis9952k	51	16	29	29	CD
cord-299731-sis9952k	51	17	]	]	-RRB-
cord-299731-sis9952k	51	18	,	,	,
cord-299731-sis9952k	51	19	which	which	WDT
cord-299731-sis9952k	51	20	further	further	RB
cord-299731-sis9952k	51	21	decreases	decrease	VBZ
cord-299731-sis9952k	51	22	the	the	DT
cord-299731-sis9952k	51	23	content	content	NN
cord-299731-sis9952k	51	24	of	of	IN
cord-299731-sis9952k	51	25	NAD	NAD	NNP
cord-299731-sis9952k	51	26	+	+	CC
cord-299731-sis9952k	51	27	[	[	-LRB-
cord-299731-sis9952k	51	28	30	30	CD
cord-299731-sis9952k	51	29	]	]	-RRB-
cord-299731-sis9952k	51	30	.	.	.
cord-299731-sis9952k	52	1	The	the	DT
cord-299731-sis9952k	52	2	effect	effect	NN
cord-299731-sis9952k	52	3	of	of	IN
cord-299731-sis9952k	52	4	CD38	CD38	NNP
cord-299731-sis9952k	52	5	on	on	IN
cord-299731-sis9952k	52	6	NAD	NAD	NNP
cord-299731-sis9952k	52	7	+	+	CC
cord-299731-sis9952k	52	8	content	content	NN
cord-299731-sis9952k	52	9	was	be	VBD
cord-299731-sis9952k	52	10	demonstrated	demonstrate	VBN
cord-299731-sis9952k	52	11	in	in	IN
cord-299731-sis9952k	52	12	CD38-deficient	cd38-deficient	CD
cord-299731-sis9952k	52	13	mice	mouse	NNS
cord-299731-sis9952k	52	14	,	,	,
cord-299731-sis9952k	52	15	whose	whose	WP$
cord-299731-sis9952k	52	16	NAD	NAD	NNP
cord-299731-sis9952k	52	17	+	+	CC
cord-299731-sis9952k	52	18	levels	level	NNS
cord-299731-sis9952k	52	19	remain	remain	VBP
cord-299731-sis9952k	52	20	high	high	JJ
cord-299731-sis9952k	52	21	.	.	.
cord-299731-sis9952k	53	1	This	this	DT
cord-299731-sis9952k	53	2	preserves	preserve	VBZ
cord-299731-sis9952k	53	3	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	53	4	respiration	respiration	NN
cord-299731-sis9952k	53	5	and	and	CC
cord-299731-sis9952k	53	6	metabolic	metabolic	JJ
cord-299731-sis9952k	53	7	function	function	NN
cord-299731-sis9952k	53	8	with	with	IN
cord-299731-sis9952k	53	9	age	age	NN
cord-299731-sis9952k	53	10	[	[	-LRB-
cord-299731-sis9952k	53	11	31	31	CD
cord-299731-sis9952k	53	12	]	]	-RRB-
cord-299731-sis9952k	53	13	.	.	.
cord-299731-sis9952k	54	1	Moreover	moreover	RB
cord-299731-sis9952k	54	2	,	,	,
cord-299731-sis9952k	54	3	the	the	DT
cord-299731-sis9952k	54	4	inhibition	inhibition	NN
cord-299731-sis9952k	54	5	of	of	IN
cord-299731-sis9952k	54	6	CD38	CD38	NNP
cord-299731-sis9952k	54	7	can	can	MD
cord-299731-sis9952k	54	8	increase	increase	VB
cord-299731-sis9952k	54	9	NAD	NAD	NNP
cord-299731-sis9952k	54	10	+	+	CC
cord-299731-sis9952k	54	11	levels	level	NNS
cord-299731-sis9952k	54	12	and	and	CC
cord-299731-sis9952k	54	13	improve	improve	VB
cord-299731-sis9952k	54	14	glucose	glucose	NN
cord-299731-sis9952k	54	15	and	and	CC
cord-299731-sis9952k	54	16	lipid	lipid	NN
cord-299731-sis9952k	54	17	metabolism	metabolism	NN
cord-299731-sis9952k	54	18	[	[	-LRB-
cord-299731-sis9952k	54	19	32	32	CD
cord-299731-sis9952k	54	20	]	]	-RRB-
cord-299731-sis9952k	54	21	.	.	.
cord-299731-sis9952k	55	1	Apart	apart	RB
cord-299731-sis9952k	55	2	from	from	IN
cord-299731-sis9952k	55	3	the	the	DT
cord-299731-sis9952k	55	4	ectoenzymes	ectoenzymes	JJ
cord-299731-sis9952k	55	5	CD38	CD38	NNP
cord-299731-sis9952k	55	6	and	and	CC
cord-299731-sis9952k	55	7	CD157	CD157	NNP
cord-299731-sis9952k	55	8	,	,	,
cord-299731-sis9952k	55	9	SARM1	SARM1	NNP
cord-299731-sis9952k	55	10	(	(	-LRB-
cord-299731-sis9952k	55	11	sterile	sterile	JJ
cord-299731-sis9952k	55	12	alpha	alpha	NN
cord-299731-sis9952k	55	13	and	and	CC
cord-299731-sis9952k	55	14	Toll	Toll	NNP
cord-299731-sis9952k	55	15	/	/	SYM
cord-299731-sis9952k	55	16	interleukin-1	interleukin-1	NN
cord-299731-sis9952k	55	17	receptor	receptor	NN
cord-299731-sis9952k	55	18	motif	motif	NN
cord-299731-sis9952k	55	19	-	-	:
cord-299731-sis9952k	55	20	containing	contain	VBG
cord-299731-sis9952k	55	21	1	1	CD
cord-299731-sis9952k	55	22	)	)	-RRB-
cord-299731-sis9952k	55	23	is	be	VBZ
cord-299731-sis9952k	55	24	an	an	DT
cord-299731-sis9952k	55	25	additional	additional	JJ
cord-299731-sis9952k	55	26	NAD	NAD	NNP
cord-299731-sis9952k	55	27	+	+	CC
cord-299731-sis9952k	55	28	-depleting	-depleting	NN
cord-299731-sis9952k	55	29	enzyme	enzyme	NN
cord-299731-sis9952k	55	30	that	that	WDT
cord-299731-sis9952k	55	31	uses	use	VBZ
cord-299731-sis9952k	55	32	NAD	NAD	NNP
cord-299731-sis9952k	55	33	+	+	CC
cord-299731-sis9952k	55	34	to	to	TO
cord-299731-sis9952k	55	35	promote	promote	VB
cord-299731-sis9952k	55	36	axonal	axonal	JJ
cord-299731-sis9952k	55	37	degeneration	degeneration	NN
cord-299731-sis9952k	55	38	after	after	IN
cord-299731-sis9952k	55	39	injury	injury	NN
cord-299731-sis9952k	55	40	and	and	CC
cord-299731-sis9952k	55	41	thereby	thereby	RB
cord-299731-sis9952k	55	42	decreases	decrease	VBZ
cord-299731-sis9952k	55	43	its	-PRON-	PRP$
cord-299731-sis9952k	55	44	overall	overall	JJ
cord-299731-sis9952k	55	45	content	content	NN
cord-299731-sis9952k	55	46	[	[	-LRB-
cord-299731-sis9952k	55	47	33	33	CD
cord-299731-sis9952k	55	48	]	]	-RRB-
cord-299731-sis9952k	55	49	.	.	.
cord-299731-sis9952k	56	1	Activation	activation	NN
cord-299731-sis9952k	56	2	of	of	IN
cord-299731-sis9952k	56	3	the	the	DT
cord-299731-sis9952k	56	4	NMRK2	NMRK2	NNP
cord-299731-sis9952k	56	5	pathway	pathway	NN
cord-299731-sis9952k	56	6	represent	represent	VBP
cord-299731-sis9952k	56	7	a	a	DT
cord-299731-sis9952k	56	8	common	common	JJ
cord-299731-sis9952k	56	9	adaptive	adaptive	JJ
cord-299731-sis9952k	56	10	mechanism	mechanism	NN
cord-299731-sis9952k	56	11	in	in	IN
cord-299731-sis9952k	56	12	the	the	DT
cord-299731-sis9952k	56	13	failing	fail	VBG
cord-299731-sis9952k	56	14	heart	heart	NN
cord-299731-sis9952k	56	15	where	where	WRB
cord-299731-sis9952k	56	16	NAD	NAD	NNP
cord-299731-sis9952k	56	17	+	+	CC
cord-299731-sis9952k	56	18	levels	level	NNS
cord-299731-sis9952k	56	19	are	be	VBP
cord-299731-sis9952k	56	20	low	low	JJ
cord-299731-sis9952k	56	21	.	.	.
cord-299731-sis9952k	57	1	NAD	NAD	NNP
cord-299731-sis9952k	57	2	+	+	CC
cord-299731-sis9952k	57	3	synthesis	synthesis	NN
cord-299731-sis9952k	57	4	from	from	IN
cord-299731-sis9952k	57	5	NR	NR	NNP
cord-299731-sis9952k	57	6	through	through	IN
cord-299731-sis9952k	57	7	the	the	DT
cord-299731-sis9952k	57	8	NMRK2	NMRK2	NNP
cord-299731-sis9952k	57	9	pathway	pathway	NN
cord-299731-sis9952k	57	10	may	may	MD
cord-299731-sis9952k	57	11	be	be	VB
cord-299731-sis9952k	57	12	favored	favor	VBN
cord-299731-sis9952k	57	13	,	,	,
cord-299731-sis9952k	57	14	as	as	IN
cord-299731-sis9952k	57	15	the	the	DT
cord-299731-sis9952k	57	16	NMN	NMN	NNP
cord-299731-sis9952k	57	17	synthesis	synthesis	NN
cord-299731-sis9952k	57	18	from	from	IN
cord-299731-sis9952k	57	19	NR	NR	NNP
cord-299731-sis9952k	57	20	by	by	IN
cord-299731-sis9952k	57	21	NMRK	NMRK	NNP
cord-299731-sis9952k	57	22	enzymes	enzyme	NNS
cord-299731-sis9952k	57	23	requires	require	VBZ
cord-299731-sis9952k	57	24	only	only	RB
cord-299731-sis9952k	57	25	one	one	CD
cord-299731-sis9952k	57	26	ATP	ATP	NNP
cord-299731-sis9952k	57	27	molecule	molecule	NN
cord-299731-sis9952k	57	28	while	while	IN
cord-299731-sis9952k	57	29	synthesis	synthesis	NN
cord-299731-sis9952k	57	30	from	from	IN
cord-299731-sis9952k	57	31	NAM	NAM	NNP
cord-299731-sis9952k	57	32	by	by	IN
cord-299731-sis9952k	57	33	NAMPT	NAMPT	NNP
cord-299731-sis9952k	57	34	requires	require	VBZ
cord-299731-sis9952k	57	35	at	at	IN
cord-299731-sis9952k	57	36	least	least	RBS
cord-299731-sis9952k	57	37	three	three	CD
cord-299731-sis9952k	57	38	ATP	ATP	NNP
cord-299731-sis9952k	57	39	equivalents	equivalent	NNS
cord-299731-sis9952k	57	40	.	.	.
cord-299731-sis9952k	58	1	The	the	DT
cord-299731-sis9952k	58	2	immense	immense	JJ
cord-299731-sis9952k	58	3	involvement	involvement	NN
cord-299731-sis9952k	58	4	of	of	IN
cord-299731-sis9952k	58	5	NAD	NAD	NNP
cord-299731-sis9952k	58	6	+	+	CC
cord-299731-sis9952k	59	1	in	in	IN
cord-299731-sis9952k	59	2	all	all	PDT
cord-299731-sis9952k	59	3	these	these	DT
cord-299731-sis9952k	59	4	processes	process	NNS
cord-299731-sis9952k	59	5	suggests	suggest	VBZ
cord-299731-sis9952k	59	6	a	a	DT
cord-299731-sis9952k	59	7	significant	significant	JJ
cord-299731-sis9952k	59	8	potential	potential	NN
cord-299731-sis9952k	59	9	for	for	IN
cord-299731-sis9952k	59	10	the	the	DT
cord-299731-sis9952k	59	11	treatment	treatment	NN
cord-299731-sis9952k	59	12	of	of	IN
cord-299731-sis9952k	59	13	various	various	JJ
cord-299731-sis9952k	59	14	pathophysiological	pathophysiological	JJ
cord-299731-sis9952k	59	15	conditions	condition	NNS
cord-299731-sis9952k	59	16	with	with	IN
cord-299731-sis9952k	59	17	supplementation	supplementation	NN
cord-299731-sis9952k	59	18	of	of	IN
cord-299731-sis9952k	59	19	NAD	NAD	NNP
cord-299731-sis9952k	59	20	+	+	CC
cord-299731-sis9952k	59	21	precursors	precursor	NNS
cord-299731-sis9952k	59	22	.	.	.
cord-299731-sis9952k	60	1	However	however	RB
cord-299731-sis9952k	60	2	,	,	,
cord-299731-sis9952k	60	3	multiple	multiple	JJ
cord-299731-sis9952k	60	4	options	option	NNS
cord-299731-sis9952k	60	5	exist	exist	VBP
cord-299731-sis9952k	60	6	for	for	IN
cord-299731-sis9952k	60	7	supplementation	supplementation	NN
cord-299731-sis9952k	60	8	,	,	,
cord-299731-sis9952k	60	9	and	and	CC
cord-299731-sis9952k	60	10	the	the	DT
cord-299731-sis9952k	60	11	optimal	optimal	JJ
cord-299731-sis9952k	60	12	precursor	precursor	NN
cord-299731-sis9952k	60	13	and	and	CC
cord-299731-sis9952k	60	14	dosage	dosage	NN
cord-299731-sis9952k	60	15	are	be	VBP
cord-299731-sis9952k	60	16	still	still	RB
cord-299731-sis9952k	60	17	unclear	unclear	JJ
cord-299731-sis9952k	60	18	with	with	IN
cord-299731-sis9952k	60	19	regard	regard	NN
cord-299731-sis9952k	60	20	to	to	IN
cord-299731-sis9952k	60	21	the	the	DT
cord-299731-sis9952k	60	22	specific	specific	JJ
cord-299731-sis9952k	60	23	condition	condition	NN
cord-299731-sis9952k	60	24	.	.	.
cord-299731-sis9952k	61	1	For	for	IN
cord-299731-sis9952k	61	2	the	the	DT
cord-299731-sis9952k	61	3	baseline	baseline	JJ
cord-299731-sis9952k	61	4	requirements	requirement	NNS
cord-299731-sis9952k	61	5	of	of	IN
cord-299731-sis9952k	61	6	NAD	NAD	NNP
cord-299731-sis9952k	61	7	+	+	CC
cord-299731-sis9952k	61	8	synthesis	synthesis	NN
cord-299731-sis9952k	61	9	,	,	,
cord-299731-sis9952k	61	10	dietary	dietary	JJ
cord-299731-sis9952k	61	11	tryptophan	tryptophan	NN
cord-299731-sis9952k	61	12	or	or	CC
cord-299731-sis9952k	61	13	less	less	JJR
cord-299731-sis9952k	61	14	than	than	IN
cord-299731-sis9952k	61	15	20	20	CD
cord-299731-sis9952k	61	16	mg	mg	NNS
cord-299731-sis9952k	61	17	of	of	IN
cord-299731-sis9952k	61	18	niacin	niacin	NN
cord-299731-sis9952k	61	19	(	(	-LRB-
cord-299731-sis9952k	61	20	NA	NA	NNP
cord-299731-sis9952k	61	21	,	,	,
cord-299731-sis9952k	61	22	NAM	NAM	NNP
cord-299731-sis9952k	61	23	)	)	-RRB-
cord-299731-sis9952k	61	24	daily	daily	RB
cord-299731-sis9952k	61	25	are	be	VBP
cord-299731-sis9952k	61	26	sufficient	sufficient	JJ
cord-299731-sis9952k	61	27	.	.	.
cord-299731-sis9952k	62	1	However	however	RB
cord-299731-sis9952k	62	2	,	,	,
cord-299731-sis9952k	62	3	growing	grow	VBG
cord-299731-sis9952k	62	4	evidence	evidence	NN
cord-299731-sis9952k	62	5	demonstrates	demonstrate	VBZ
cord-299731-sis9952k	62	6	that	that	IN
cord-299731-sis9952k	62	7	substantially	substantially	RB
cord-299731-sis9952k	62	8	greater	great	JJR
cord-299731-sis9952k	62	9	rates	rate	NNS
cord-299731-sis9952k	62	10	of	of	IN
cord-299731-sis9952k	62	11	NAD	NAD	NNP
cord-299731-sis9952k	62	12	+	+	CC
cord-299731-sis9952k	62	13	synthesis	synthesis	NN
cord-299731-sis9952k	62	14	exhibit	exhibit	VBP
cord-299731-sis9952k	62	15	numerous	numerous	JJ
cord-299731-sis9952k	62	16	beneficial	beneficial	JJ
cord-299731-sis9952k	62	17	or	or	CC
cord-299731-sis9952k	62	18	even	even	RB
cord-299731-sis9952k	62	19	therapeutic	therapeutic	JJ
cord-299731-sis9952k	62	20	effects	effect	NNS
cord-299731-sis9952k	62	21	,	,	,
cord-299731-sis9952k	62	22	which	which	WDT
cord-299731-sis9952k	62	23	can	can	MD
cord-299731-sis9952k	62	24	be	be	VB
cord-299731-sis9952k	62	25	achieved	achieve	VBN
cord-299731-sis9952k	62	26	by	by	IN
cord-299731-sis9952k	62	27	supplementation	supplementation	NN
cord-299731-sis9952k	62	28	of	of	IN
cord-299731-sis9952k	62	29	its	-PRON-	PRP$
cord-299731-sis9952k	62	30	intermediates	intermediate	NNS
cord-299731-sis9952k	62	31	.	.	.
cord-299731-sis9952k	63	1	These	these	DT
cord-299731-sis9952k	63	2	intermediates	intermediate	NNS
cord-299731-sis9952k	63	3	are	be	VBP
cord-299731-sis9952k	63	4	found	find	VBN
cord-299731-sis9952k	63	5	in	in	IN
cord-299731-sis9952k	63	6	a	a	DT
cord-299731-sis9952k	63	7	wide	wide	JJ
cord-299731-sis9952k	63	8	variety	variety	NN
cord-299731-sis9952k	63	9	of	of	IN
cord-299731-sis9952k	63	10	foods	food	NNS
cord-299731-sis9952k	63	11	,	,	,
cord-299731-sis9952k	63	12	including	include	VBG
cord-299731-sis9952k	63	13	meat	meat	NN
cord-299731-sis9952k	63	14	,	,	,
cord-299731-sis9952k	63	15	eggs	egg	NNS
cord-299731-sis9952k	63	16	,	,	,
cord-299731-sis9952k	63	17	dairy	dairy	NN
cord-299731-sis9952k	63	18	,	,	,
cord-299731-sis9952k	63	19	certain	certain	JJ
cord-299731-sis9952k	63	20	vegetables	vegetable	NNS
cord-299731-sis9952k	63	21	and	and	CC
cord-299731-sis9952k	63	22	whole	whole	JJ
cord-299731-sis9952k	63	23	wheat	wheat	NN
cord-299731-sis9952k	63	24	[	[	-LRB-
cord-299731-sis9952k	63	25	35	35	CD
cord-299731-sis9952k	63	26	,	,	,
cord-299731-sis9952k	63	27	36	36	CD
cord-299731-sis9952k	63	28	]	]	-RRB-
cord-299731-sis9952k	63	29	.	.	.
cord-299731-sis9952k	64	1	Specifically	specifically	RB
cord-299731-sis9952k	64	2	,	,	,
cord-299731-sis9952k	64	3	NR	NR	NNP
cord-299731-sis9952k	64	4	is	be	VBZ
cord-299731-sis9952k	64	5	the	the	DT
cord-299731-sis9952k	64	6	third	third	JJ
cord-299731-sis9952k	64	7	discovered	discover	VBN
cord-299731-sis9952k	64	8	NAD	NAD	NNP
cord-299731-sis9952k	64	9	+	+	CC
cord-299731-sis9952k	64	10	precursor	precursor	NN
cord-299731-sis9952k	64	11	that	that	WDT
cord-299731-sis9952k	64	12	naturally	naturally	RB
cord-299731-sis9952k	64	13	occurs	occur	VBZ
cord-299731-sis9952k	64	14	in	in	IN
cord-299731-sis9952k	64	15	milk	milk	NN
cord-299731-sis9952k	64	16	and	and	CC
cord-299731-sis9952k	64	17	is	be	VBZ
cord-299731-sis9952k	64	18	already	already	RB
cord-299731-sis9952k	64	19	available	available	JJ
cord-299731-sis9952k	64	20	as	as	IN
cord-299731-sis9952k	64	21	a	a	DT
cord-299731-sis9952k	64	22	nutraceutical	nutraceutical	NN
cord-299731-sis9952k	64	23	.	.	.
cord-299731-sis9952k	65	1	Oral	oral	JJ
cord-299731-sis9952k	65	2	supplementation	supplementation	NN
cord-299731-sis9952k	65	3	with	with	IN
cord-299731-sis9952k	65	4	NR	NR	NNP
cord-299731-sis9952k	65	5	has	have	VBZ
cord-299731-sis9952k	65	6	been	be	VBN
cord-299731-sis9952k	65	7	shown	show	VBN
cord-299731-sis9952k	65	8	to	to	TO
cord-299731-sis9952k	65	9	increase	increase	VB
cord-299731-sis9952k	65	10	NAD	NAD	NNP
cord-299731-sis9952k	66	1	+	+	CC
cord-299731-sis9952k	66	2	levels	level	NNS
cord-299731-sis9952k	66	3	in	in	IN
cord-299731-sis9952k	66	4	multiple	multiple	JJ
cord-299731-sis9952k	66	5	tissues	tissue	NNS
cord-299731-sis9952k	66	6	,	,	,
cord-299731-sis9952k	66	7	along	along	IN
cord-299731-sis9952k	66	8	with	with	IN
cord-299731-sis9952k	66	9	increased	increase	VBN
cord-299731-sis9952k	66	10	SIRT	SIRT	NNP
cord-299731-sis9952k	66	11	activity	activity	NN
cord-299731-sis9952k	66	12	[	[	-LRB-
cord-299731-sis9952k	66	13	10	10	CD
cord-299731-sis9952k	66	14	,	,	,
cord-299731-sis9952k	66	15	11	11	CD
cord-299731-sis9952k	66	16	]	]	-RRB-
cord-299731-sis9952k	66	17	,	,	,
cord-299731-sis9952k	66	18	improved	improve	VBN
cord-299731-sis9952k	66	19	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	66	20	function	function	NN
cord-299731-sis9952k	66	21	[	[	-LRB-
cord-299731-sis9952k	66	22	37	37	CD
cord-299731-sis9952k	66	23	]	]	-RRB-
cord-299731-sis9952k	66	24	,	,	,
cord-299731-sis9952k	66	25	and	and	CC
cord-299731-sis9952k	66	26	regenerative	regenerative	JJ
cord-299731-sis9952k	66	27	potential	potential	NN
cord-299731-sis9952k	66	28	of	of	IN
cord-299731-sis9952k	66	29	stem	stem	NN
cord-299731-sis9952k	66	30	cells	cell	NNS
cord-299731-sis9952k	66	31	[	[	-LRB-
cord-299731-sis9952k	66	32	38	38	CD
cord-299731-sis9952k	66	33	]	]	-RRB-
cord-299731-sis9952k	66	34	.	.	.
cord-299731-sis9952k	67	1	Furthermore	furthermore	RB
cord-299731-sis9952k	67	2	,	,	,
cord-299731-sis9952k	67	3	NR	NR	NNP
cord-299731-sis9952k	67	4	is	be	VBZ
cord-299731-sis9952k	67	5	currently	currently	RB
cord-299731-sis9952k	67	6	regarded	regard	VBN
cord-299731-sis9952k	67	7	as	as	IN
cord-299731-sis9952k	67	8	a	a	DT
cord-299731-sis9952k	67	9	favorable	favorable	JJ
cord-299731-sis9952k	67	10	precursor	precursor	NN
cord-299731-sis9952k	67	11	since	since	IN
cord-299731-sis9952k	67	12	it	-PRON-	PRP
cord-299731-sis9952k	67	13	has	have	VBZ
cord-299731-sis9952k	67	14	not	not	RB
cord-299731-sis9952k	67	15	been	be	VBN
cord-299731-sis9952k	67	16	implicated	implicate	VBN
cord-299731-sis9952k	67	17	to	to	TO
cord-299731-sis9952k	67	18	have	have	VB
cord-299731-sis9952k	67	19	serious	serious	JJ
cord-299731-sis9952k	67	20	side	side	NN
cord-299731-sis9952k	67	21	effects	effect	NNS
cord-299731-sis9952k	67	22	or	or	CC
cord-299731-sis9952k	67	23	flushing	flush	VBG
cord-299731-sis9952k	67	24	as	as	IN
cord-299731-sis9952k	67	25	opposed	oppose	VBN
cord-299731-sis9952k	67	26	to	to	IN
cord-299731-sis9952k	67	27	other	other	JJ
cord-299731-sis9952k	67	28	NAD	NAD	NNP
cord-299731-sis9952k	67	29	+	+	CC
cord-299731-sis9952k	67	30	precursors	precursor	NNS
cord-299731-sis9952k	67	31	[	[	-LRB-
cord-299731-sis9952k	67	32	14	14	CD
cord-299731-sis9952k	67	33	,	,	,
cord-299731-sis9952k	67	34	39	39	CD
cord-299731-sis9952k	67	35	]	]	-RRB-
cord-299731-sis9952k	67	36	.	.	.
cord-299731-sis9952k	68	1	NR	NR	NNP
cord-299731-sis9952k	68	2	chloride	chloride	NN
cord-299731-sis9952k	68	3	has	have	VBZ
cord-299731-sis9952k	68	4	been	be	VBN
cord-299731-sis9952k	68	5	given	give	VBN
cord-299731-sis9952k	68	6	GRAS	gras	NN
cord-299731-sis9952k	68	7	status	status	NN
cord-299731-sis9952k	68	8	(	(	-LRB-
cord-299731-sis9952k	68	9	generally	generally	RB
cord-299731-sis9952k	68	10	regarded	regard	VBN
cord-299731-sis9952k	68	11	as	as	IN
cord-299731-sis9952k	68	12	safe	safe	JJ
cord-299731-sis9952k	68	13	)	)	-RRB-
cord-299731-sis9952k	68	14	which	which	WDT
cord-299731-sis9952k	68	15	further	further	RB
cord-299731-sis9952k	68	16	supports	support	VBZ
cord-299731-sis9952k	68	17	its	-PRON-	PRP$
cord-299731-sis9952k	68	18	rapid	rapid	JJ
cord-299731-sis9952k	68	19	implementation	implementation	NN
cord-299731-sis9952k	68	20	as	as	IN
cord-299731-sis9952k	68	21	a	a	DT
cord-299731-sis9952k	68	22	drug	drug	NN
cord-299731-sis9952k	68	23	-	-	HYPH
cord-299731-sis9952k	68	24	like	like	JJ
cord-299731-sis9952k	68	25	therapy	therapy	NN
cord-299731-sis9952k	68	26	.	.	.
cord-299731-sis9952k	69	1	However	however	RB
cord-299731-sis9952k	69	2	,	,	,
cord-299731-sis9952k	69	3	to	to	TO
cord-299731-sis9952k	69	4	adapt	adapt	VB
cord-299731-sis9952k	69	5	NR	NR	NNP
cord-299731-sis9952k	69	6	technologies	technology	NNS
cord-299731-sis9952k	69	7	for	for	IN
cord-299731-sis9952k	69	8	therapeutic	therapeutic	JJ
cord-299731-sis9952k	69	9	use	use	NN
cord-299731-sis9952k	69	10	,	,	,
cord-299731-sis9952k	69	11	it	-PRON-	PRP
cord-299731-sis9952k	69	12	is	be	VBZ
cord-299731-sis9952k	69	13	necessary	necessary	JJ
cord-299731-sis9952k	69	14	to	to	TO
cord-299731-sis9952k	69	15	determine	determine	VB
cord-299731-sis9952k	69	16	oral	oral	JJ
cord-299731-sis9952k	69	17	availability	availability	NN
cord-299731-sis9952k	69	18	,	,	,
cord-299731-sis9952k	69	19	therapeutic	therapeutic	JJ
cord-299731-sis9952k	69	20	dosage	dosage	NN
cord-299731-sis9952k	69	21	,	,	,
cord-299731-sis9952k	69	22	and	and	CC
cord-299731-sis9952k	69	23	utilization	utilization	NN
cord-299731-sis9952k	69	24	in	in	IN
cord-299731-sis9952k	69	25	different	different	JJ
cord-299731-sis9952k	69	26	tissues	tissue	NNS
cord-299731-sis9952k	69	27	.	.	.
cord-299731-sis9952k	70	1	Human	human	JJ
cord-299731-sis9952k	70	2	digestion	digestion	NN
cord-299731-sis9952k	70	3	and	and	CC
cord-299731-sis9952k	70	4	the	the	DT
cord-299731-sis9952k	70	5	microbiome	microbiome	NN
cord-299731-sis9952k	70	6	[	[	-LRB-
cord-299731-sis9952k	70	7	40	40	CD
cord-299731-sis9952k	70	8	]	]	-RRB-
cord-299731-sis9952k	70	9	additionally	additionally	RB
cord-299731-sis9952k	70	10	play	play	VBP
cord-299731-sis9952k	70	11	important	important	JJ
cord-299731-sis9952k	70	12	roles	role	NNS
cord-299731-sis9952k	70	13	in	in	IN
cord-299731-sis9952k	70	14	NR	NR	NNP
cord-299731-sis9952k	70	15	metabolism	metabolism	NN
cord-299731-sis9952k	70	16	,	,	,
cord-299731-sis9952k	70	17	which	which	WDT
cord-299731-sis9952k	70	18	has	have	VBZ
cord-299731-sis9952k	70	19	yet	yet	RB
cord-299731-sis9952k	70	20	to	to	TO
cord-299731-sis9952k	70	21	be	be	VB
cord-299731-sis9952k	70	22	characterized	characterize	VBN
cord-299731-sis9952k	70	23	in	in	IN
cord-299731-sis9952k	70	24	detail	detail	NN
cord-299731-sis9952k	70	25	.	.	.
cord-299731-sis9952k	71	1	In	in	IN
cord-299731-sis9952k	71	2	this	this	DT
cord-299731-sis9952k	71	3	regard	regard	NN
cord-299731-sis9952k	71	4	,	,	,
cord-299731-sis9952k	71	5	we	-PRON-	PRP
cord-299731-sis9952k	71	6	have	have	VBP
cord-299731-sis9952k	71	7	summarized	summarize	VBN
cord-299731-sis9952k	71	8	the	the	DT
cord-299731-sis9952k	71	9	available	available	JJ
cord-299731-sis9952k	71	10	data	datum	NNS
cord-299731-sis9952k	71	11	from	from	IN
cord-299731-sis9952k	71	12	human	human	JJ
cord-299731-sis9952k	71	13	and	and	CC
cord-299731-sis9952k	71	14	animal	animal	NN
cord-299731-sis9952k	71	15	studies	study	NNS
cord-299731-sis9952k	71	16	on	on	IN
cord-299731-sis9952k	71	17	NR	NR	NNP
cord-299731-sis9952k	71	18	effects	effect	NNS
cord-299731-sis9952k	71	19	on	on	IN
cord-299731-sis9952k	71	20	metabolic	metabolic	JJ
cord-299731-sis9952k	71	21	,	,	,
cord-299731-sis9952k	71	22	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	71	23	,	,	,
cord-299731-sis9952k	71	24	and	and	CC
cord-299731-sis9952k	71	25	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	71	26	disorders	disorder	NNS
cord-299731-sis9952k	71	27	,	,	,
cord-299731-sis9952k	71	28	along	along	IN
cord-299731-sis9952k	71	29	with	with	IN
cord-299731-sis9952k	71	30	the	the	DT
cord-299731-sis9952k	71	31	advantages	advantage	NNS
cord-299731-sis9952k	71	32	of	of	IN
cord-299731-sis9952k	71	33	NR	NR	NNP
cord-299731-sis9952k	71	34	over	over	IN
cord-299731-sis9952k	71	35	other	other	JJ
cord-299731-sis9952k	71	36	available	available	JJ
cord-299731-sis9952k	71	37	NAD	NAD	NNP
cord-299731-sis9952k	71	38	+	+	CC
cord-299731-sis9952k	71	39	precursors	precursor	NNS
cord-299731-sis9952k	71	40	.	.	.
cord-299731-sis9952k	72	1	We	-PRON-	PRP
cord-299731-sis9952k	72	2	also	also	RB
cord-299731-sis9952k	72	3	considered	consider	VBD
cord-299731-sis9952k	72	4	immunomodulatory	immunomodulatory	JJ
cord-299731-sis9952k	72	5	effects	effect	NNS
cord-299731-sis9952k	72	6	in	in	IN
cord-299731-sis9952k	72	7	this	this	DT
cord-299731-sis9952k	72	8	review	review	NN
cord-299731-sis9952k	72	9	,	,	,
cord-299731-sis9952k	72	10	as	as	IN
cord-299731-sis9952k	72	11	recent	recent	JJ
cord-299731-sis9952k	72	12	data	data	NN
cord-299731-sis9952k	72	13	indicates	indicate	VBZ
cord-299731-sis9952k	72	14	that	that	IN
cord-299731-sis9952k	72	15	NR	NR	NNP
cord-299731-sis9952k	72	16	can	can	MD
cord-299731-sis9952k	72	17	support	support	VB
cord-299731-sis9952k	72	18	the	the	DT
cord-299731-sis9952k	72	19	treatment	treatment	NN
cord-299731-sis9952k	72	20	of	of	IN
cord-299731-sis9952k	72	21	infections	infection	NNS
cord-299731-sis9952k	72	22	,	,	,
cord-299731-sis9952k	72	23	including	include	VBG
cord-299731-sis9952k	72	24	those	those	DT
cord-299731-sis9952k	72	25	caused	cause	VBN
cord-299731-sis9952k	72	26	by	by	IN
cord-299731-sis9952k	72	27	SARS	SARS	NNP
cord-299731-sis9952k	72	28	-	-	HYPH
cord-299731-sis9952k	72	29	CoV-2	CoV-2	NNP
cord-299731-sis9952k	72	30	that	that	WDT
cord-299731-sis9952k	72	31	has	have	VBZ
cord-299731-sis9952k	72	32	resulted	result	VBN
cord-299731-sis9952k	72	33	in	in	IN
cord-299731-sis9952k	72	34	the	the	DT
cord-299731-sis9952k	72	35	recent	recent	JJ
cord-299731-sis9952k	72	36	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	72	37	pandemic	pandemic	NN
cord-299731-sis9952k	72	38	.	.	.
cord-299731-sis9952k	73	1	The	the	DT
cord-299731-sis9952k	73	2	current	current	JJ
cord-299731-sis9952k	73	3	state	state	NN
cord-299731-sis9952k	73	4	of	of	IN
cord-299731-sis9952k	73	5	NR	NR	NNP
cord-299731-sis9952k	73	6	research	research	NN
cord-299731-sis9952k	73	7	including	include	VBG
cord-299731-sis9952k	73	8	its	-PRON-	PRP$
cord-299731-sis9952k	73	9	bioavailability	bioavailability	NN
cord-299731-sis9952k	73	10	,	,	,
cord-299731-sis9952k	73	11	safety	safety	NN
cord-299731-sis9952k	73	12	,	,	,
cord-299731-sis9952k	73	13	and	and	CC
cord-299731-sis9952k	73	14	effects	effect	NNS
cord-299731-sis9952k	73	15	on	on	IN
cord-299731-sis9952k	73	16	oxidative	oxidative	JJ
cord-299731-sis9952k	73	17	stress	stress	NN
cord-299731-sis9952k	73	18	and	and	CC
cord-299731-sis9952k	73	19	longevity	longevity	NN
cord-299731-sis9952k	73	20	is	be	VBZ
cord-299731-sis9952k	73	21	described	describe	VBN
cord-299731-sis9952k	73	22	in	in	IN
cord-299731-sis9952k	73	23	this	this	DT
cord-299731-sis9952k	73	24	paper	paper	NN
cord-299731-sis9952k	73	25	.	.	.
cord-299731-sis9952k	74	1	We	-PRON-	PRP
cord-299731-sis9952k	74	2	searched	search	VBD
cord-299731-sis9952k	74	3	mostly	mostly	RB
cord-299731-sis9952k	74	4	the	the	DT
cord-299731-sis9952k	74	5	PubMed	PubMed	NNP
cord-299731-sis9952k	74	6	database	database	NN
cord-299731-sis9952k	74	7	for	for	IN
cord-299731-sis9952k	74	8	papers	paper	NNS
cord-299731-sis9952k	74	9	published	publish	VBN
cord-299731-sis9952k	74	10	in	in	IN
cord-299731-sis9952k	74	11	open	open	JJ
cord-299731-sis9952k	74	12	-	-	HYPH
cord-299731-sis9952k	74	13	access	access	NN
cord-299731-sis9952k	74	14	peer	peer	NN
cord-299731-sis9952k	74	15	-	-	HYPH
cord-299731-sis9952k	74	16	reviewed	review	VBN
cord-299731-sis9952k	74	17	journals	journal	NNS
cord-299731-sis9952k	74	18	.	.	.
cord-299731-sis9952k	75	1	In	in	IN
cord-299731-sis9952k	75	2	addition	addition	NN
cord-299731-sis9952k	75	3	,	,	,
cord-299731-sis9952k	75	4	we	-PRON-	PRP
cord-299731-sis9952k	75	5	used	use	VBD
cord-299731-sis9952k	75	6	available	available	JJ
cord-299731-sis9952k	75	7	abstracts	abstract	NNS
cord-299731-sis9952k	75	8	of	of	IN
cord-299731-sis9952k	75	9	papers	paper	NNS
cord-299731-sis9952k	75	10	or	or	CC
cord-299731-sis9952k	75	11	entire	entire	JJ
cord-299731-sis9952k	75	12	articles	article	NNS
cord-299731-sis9952k	75	13	on	on	IN
cord-299731-sis9952k	75	14	ResearchGate	ResearchGate	NNP
cord-299731-sis9952k	75	15	without	without	IN
cord-299731-sis9952k	75	16	open	open	JJ
cord-299731-sis9952k	75	17	access	access	NN
cord-299731-sis9952k	75	18	.	.	.
cord-299731-sis9952k	76	1	We	-PRON-	PRP
cord-299731-sis9952k	76	2	used	use	VBD
cord-299731-sis9952k	76	3	publication	publication	NN
cord-299731-sis9952k	76	4	date	date	NN
cord-299731-sis9952k	76	5	as	as	IN
cord-299731-sis9952k	76	6	a	a	DT
cord-299731-sis9952k	76	7	priority	priority	NN
cord-299731-sis9952k	76	8	to	to	TO
cord-299731-sis9952k	76	9	select	select	VB
cord-299731-sis9952k	76	10	the	the	DT
cord-299731-sis9952k	76	11	papers	paper	NNS
cord-299731-sis9952k	76	12	,	,	,
cord-299731-sis9952k	76	13	and	and	CC
cord-299731-sis9952k	76	14	most	most	JJS
cord-299731-sis9952k	76	15	of	of	IN
cord-299731-sis9952k	76	16	the	the	DT
cord-299731-sis9952k	76	17	reviewed	review	VBN
cord-299731-sis9952k	76	18	papers	paper	NNS
cord-299731-sis9952k	76	19	have	have	VBP
cord-299731-sis9952k	76	20	been	be	VBN
cord-299731-sis9952k	76	21	published	publish	VBN
cord-299731-sis9952k	76	22	within	within	IN
cord-299731-sis9952k	76	23	the	the	DT
cord-299731-sis9952k	76	24	last	last	JJ
cord-299731-sis9952k	76	25	10	10	CD
cord-299731-sis9952k	76	26	-	-	SYM
cord-299731-sis9952k	76	27	15	15	CD
cord-299731-sis9952k	76	28	years	year	NNS
cord-299731-sis9952k	76	29	.	.	.
cord-299731-sis9952k	77	1	Older	old	JJR
cord-299731-sis9952k	77	2	papers	paper	NNS
cord-299731-sis9952k	77	3	were	be	VBD
cord-299731-sis9952k	77	4	considered	consider	VBN
cord-299731-sis9952k	77	5	more	more	JJR
cord-299731-sis9952k	77	6	as	as	IN
cord-299731-sis9952k	77	7	a	a	DT
cord-299731-sis9952k	77	8	source	source	NN
cord-299731-sis9952k	77	9	of	of	IN
cord-299731-sis9952k	77	10	fundamental	fundamental	JJ
cord-299731-sis9952k	77	11	discoveries	discovery	NNS
cord-299731-sis9952k	77	12	.	.	.
cord-299731-sis9952k	78	1	Additional	additional	JJ
cord-299731-sis9952k	78	2	databases	database	NNS
cord-299731-sis9952k	78	3	were	be	VBD
cord-299731-sis9952k	78	4	also	also	RB
cord-299731-sis9952k	78	5	searched	search	VBN
cord-299731-sis9952k	78	6	via	via	IN
cord-299731-sis9952k	78	7	Google	Google	NNP
cord-299731-sis9952k	78	8	using	use	VBG
cord-299731-sis9952k	78	9	the	the	DT
cord-299731-sis9952k	78	10	following	follow	VBG
cord-299731-sis9952k	78	11	keywords	keyword	NNS
cord-299731-sis9952k	78	12	:	:	:
cord-299731-sis9952k	78	13	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	78	14	riboside	riboside	NN
cord-299731-sis9952k	78	15	(	(	-LRB-
cord-299731-sis9952k	78	16	NR	nr	NN
cord-299731-sis9952k	78	17	)	)	-RRB-
cord-299731-sis9952k	78	18	bioavailability	bioavailability	NN
cord-299731-sis9952k	78	19	,	,	,
cord-299731-sis9952k	78	20	NR	NR	NNP
cord-299731-sis9952k	78	21	safety	safety	NN
cord-299731-sis9952k	78	22	,	,	,
cord-299731-sis9952k	78	23	NR	NR	NNP
cord-299731-sis9952k	78	24	supplementation	supplementation	NN
cord-299731-sis9952k	78	25	,	,	,
cord-299731-sis9952k	78	26	NR	NR	NNP
cord-299731-sis9952k	78	27	effects	effect	NNS
cord-299731-sis9952k	78	28	on	on	IN
cord-299731-sis9952k	78	29	metabolism	metabolism	NN
cord-299731-sis9952k	78	30	and	and	CC
cord-299731-sis9952k	78	31	insulin	insulin	NN
cord-299731-sis9952k	78	32	,	,	,
cord-299731-sis9952k	78	33	NR	NR	NNP
cord-299731-sis9952k	78	34	effects	effect	NNS
cord-299731-sis9952k	78	35	on	on	IN
cord-299731-sis9952k	78	36	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	78	37	disorders	disorder	NNS
cord-299731-sis9952k	78	38	,	,	,
cord-299731-sis9952k	78	39	NR	NR	NNP
cord-299731-sis9952k	78	40	effects	effect	NNS
cord-299731-sis9952k	78	41	on	on	IN
cord-299731-sis9952k	78	42	longevity	longevity	NN
cord-299731-sis9952k	78	43	,	,	,
cord-299731-sis9952k	78	44	NR	NR	NNP
cord-299731-sis9952k	78	45	effects	effect	NNS
cord-299731-sis9952k	78	46	on	on	IN
cord-299731-sis9952k	78	47	liver	liver	NN
cord-299731-sis9952k	78	48	health	health	NN
cord-299731-sis9952k	78	49	,	,	,
cord-299731-sis9952k	78	50	and	and	CC
cord-299731-sis9952k	78	51	similar	similar	JJ
cord-299731-sis9952k	78	52	.	.	.
cord-299731-sis9952k	79	1	Along	along	IN
cord-299731-sis9952k	79	2	with	with	IN
cord-299731-sis9952k	79	3	its	-PRON-	PRP$
cord-299731-sis9952k	79	4	intermediates	intermediate	NNS
cord-299731-sis9952k	79	5	,	,	,
cord-299731-sis9952k	79	6	NAD	NAD	NNP
cord-299731-sis9952k	80	1	+	+	CC
cord-299731-sis9952k	80	2	plays	play	VBZ
cord-299731-sis9952k	80	3	an	an	DT
cord-299731-sis9952k	80	4	essential	essential	JJ
cord-299731-sis9952k	80	5	role	role	NN
cord-299731-sis9952k	80	6	in	in	IN
cord-299731-sis9952k	80	7	metabolism	metabolism	NN
cord-299731-sis9952k	80	8	,	,	,
cord-299731-sis9952k	80	9	and	and	CC
cord-299731-sis9952k	80	10	evidence	evidence	NN
cord-299731-sis9952k	80	11	suggests	suggest	VBZ
cord-299731-sis9952k	80	12	that	that	IN
cord-299731-sis9952k	80	13	an	an	DT
cord-299731-sis9952k	80	14	increase	increase	NN
cord-299731-sis9952k	80	15	in	in	IN
cord-299731-sis9952k	80	16	NAD	NAD	NNP
cord-299731-sis9952k	80	17	+	+	CC
cord-299731-sis9952k	80	18	levels	level	NNS
cord-299731-sis9952k	80	19	can	can	MD
cord-299731-sis9952k	80	20	exhibit	exhibit	VB
cord-299731-sis9952k	80	21	ameliorating	ameliorate	VBG
cord-299731-sis9952k	80	22	effects	effect	NNS
cord-299731-sis9952k	80	23	on	on	IN
cord-299731-sis9952k	80	24	metabolic	metabolic	JJ
cord-299731-sis9952k	80	25	disorders	disorder	NNS
cord-299731-sis9952k	80	26	,	,	,
cord-299731-sis9952k	80	27	such	such	JJ
cord-299731-sis9952k	80	28	as	as	IN
cord-299731-sis9952k	80	29	type	type	NN
cord-299731-sis9952k	80	30	2	2	CD
cord-299731-sis9952k	80	31	diabetes	diabetes	NN
cord-299731-sis9952k	80	32	(	(	-LRB-
cord-299731-sis9952k	80	33	T2D	t2d	CD
cord-299731-sis9952k	80	34	)	)	-RRB-
cord-299731-sis9952k	80	35	,	,	,
cord-299731-sis9952k	80	36	metabolic	metabolic	JJ
cord-299731-sis9952k	80	37	syndrome	syndrome	NN
cord-299731-sis9952k	80	38	,	,	,
cord-299731-sis9952k	80	39	and	and	CC
cord-299731-sis9952k	80	40	nonalcoholic	nonalcoholic	JJ
cord-299731-sis9952k	80	41	fatty	fatty	JJ
cord-299731-sis9952k	80	42	liver	liver	NN
cord-299731-sis9952k	80	43	disease	disease	NN
cord-299731-sis9952k	80	44	(	(	-LRB-
cord-299731-sis9952k	80	45	NAFLD	NAFLD	NNP
cord-299731-sis9952k	80	46	)	)	-RRB-
cord-299731-sis9952k	80	47	[	[	-LRB-
cord-299731-sis9952k	80	48	14	14	CD
cord-299731-sis9952k	80	49	,	,	,
cord-299731-sis9952k	80	50	41	41	CD
cord-299731-sis9952k	80	51	,	,	,
cord-299731-sis9952k	80	52	42	42	CD
cord-299731-sis9952k	80	53	]	]	-RRB-
cord-299731-sis9952k	80	54	.	.	.
cord-299731-sis9952k	81	1	Furthermore	furthermore	RB
cord-299731-sis9952k	81	2	,	,	,
cord-299731-sis9952k	81	3	NR	NR	NNP
cord-299731-sis9952k	81	4	is	be	VBZ
cord-299731-sis9952k	81	5	one	one	CD
cord-299731-sis9952k	81	6	of	of	IN
cord-299731-sis9952k	81	7	the	the	DT
cord-299731-sis9952k	81	8	NAD	NAD	NNP
cord-299731-sis9952k	81	9	+	+	CC
cord-299731-sis9952k	81	10	intermediates	intermediate	NNS
cord-299731-sis9952k	81	11	that	that	WDT
cord-299731-sis9952k	81	12	also	also	RB
cord-299731-sis9952k	81	13	serves	serve	VBZ
cord-299731-sis9952k	81	14	as	as	IN
cord-299731-sis9952k	81	15	a	a	DT
cord-299731-sis9952k	81	16	precursor	precursor	NN
cord-299731-sis9952k	81	17	of	of	IN
cord-299731-sis9952k	81	18	NADH	NADH	NNP
cord-299731-sis9952k	81	19	,	,	,
cord-299731-sis9952k	81	20	as	as	RB
cord-299731-sis9952k	81	21	well	well	RB
cord-299731-sis9952k	81	22	as	as	IN
cord-299731-sis9952k	81	23	hepatic	hepatic	JJ
cord-299731-sis9952k	81	24	NADP	NADP	NNP
cord-299731-sis9952k	82	1	+	+	CC
cord-299731-sis9952k	83	1	and	and	CC
cord-299731-sis9952k	83	2	NADPH	NADPH	NNP
cord-299731-sis9952k	83	3	[	[	-LRB-
cord-299731-sis9952k	83	4	14	14	CD
cord-299731-sis9952k	83	5	]	]	-RRB-
cord-299731-sis9952k	83	6	.	.	.
cord-299731-sis9952k	84	1	Since	since	IN
cord-299731-sis9952k	84	2	the	the	DT
cord-299731-sis9952k	84	3	hepatic	hepatic	JJ
cord-299731-sis9952k	84	4	NAD	NAD	NNP
cord-299731-sis9952k	84	5	+	+	CC
cord-299731-sis9952k	84	6	metabolome	metabolome	NNP
cord-299731-sis9952k	84	7	is	be	VBZ
cord-299731-sis9952k	84	8	regarded	regard	VBN
cord-299731-sis9952k	84	9	as	as	IN
cord-299731-sis9952k	84	10	a	a	DT
cord-299731-sis9952k	84	11	function	function	NN
cord-299731-sis9952k	84	12	of	of	IN
cord-299731-sis9952k	84	13	prediabetic	prediabetic	JJ
cord-299731-sis9952k	84	14	(	(	-LRB-
cord-299731-sis9952k	84	15	PD	PD	NNP
cord-299731-sis9952k	84	16	)	)	-RRB-
cord-299731-sis9952k	84	17	and	and	CC
cord-299731-sis9952k	84	18	T2D	t2d	DT
cord-299731-sis9952k	84	19	mouse	mouse	NN
cord-299731-sis9952k	84	20	models	model	NNS
cord-299731-sis9952k	84	21	,	,	,
cord-299731-sis9952k	84	22	NADP	NADP	NNP
cord-299731-sis9952k	84	23	+	+	SYM
cord-299731-sis9952k	84	24	and	and	CC
cord-299731-sis9952k	84	25	NADPH	NADPH	NNP
cord-299731-sis9952k	84	26	can	can	MD
cord-299731-sis9952k	84	27	be	be	VB
cord-299731-sis9952k	84	28	used	use	VBN
cord-299731-sis9952k	84	29	to	to	TO
cord-299731-sis9952k	84	30	assess	assess	VB
cord-299731-sis9952k	84	31	the	the	DT
cord-299731-sis9952k	84	32	progression	progression	NN
cord-299731-sis9952k	84	33	of	of	IN
cord-299731-sis9952k	84	34	the	the	DT
cord-299731-sis9952k	84	35	disease	disease	NN
cord-299731-sis9952k	84	36	.	.	.
cord-299731-sis9952k	85	1	Namely	namely	RB
cord-299731-sis9952k	85	2	,	,	,
cord-299731-sis9952k	85	3	both	both	CC
cord-299731-sis9952k	85	4	NADP	NADP	NNP
cord-299731-sis9952k	85	5	+	+	SYM
cord-299731-sis9952k	85	6	and	and	CC
cord-299731-sis9952k	85	7	NADPH	NADPH	NNP
cord-299731-sis9952k	85	8	are	be	VBP
cord-299731-sis9952k	85	9	important	important	JJ
cord-299731-sis9952k	85	10	for	for	IN
cord-299731-sis9952k	85	11	resistance	resistance	NN
cord-299731-sis9952k	85	12	to	to	IN
cord-299731-sis9952k	85	13	oxidative	oxidative	JJ
cord-299731-sis9952k	85	14	stress	stress	NN
cord-299731-sis9952k	85	15	,	,	,
cord-299731-sis9952k	85	16	while	while	IN
cord-299731-sis9952k	85	17	NADPH	NADPH	NNP
cord-299731-sis9952k	85	18	is	be	VBZ
cord-299731-sis9952k	85	19	thought	think	VBN
cord-299731-sis9952k	85	20	to	to	TO
cord-299731-sis9952k	85	21	be	be	VB
cord-299731-sis9952k	85	22	the	the	DT
cord-299731-sis9952k	85	23	major	major	JJ
cord-299731-sis9952k	85	24	contributor	contributor	NN
cord-299731-sis9952k	85	25	to	to	IN
cord-299731-sis9952k	85	26	insulin	insulin	NN
cord-299731-sis9952k	85	27	resistance	resistance	NN
cord-299731-sis9952k	85	28	[	[	-LRB-
cord-299731-sis9952k	85	29	42	42	CD
cord-299731-sis9952k	85	30	]	]	-RRB-
cord-299731-sis9952k	85	31	.	.	.
cord-299731-sis9952k	86	1	The	the	DT
cord-299731-sis9952k	86	2	significantly	significantly	RB
cord-299731-sis9952k	86	3	decreased	decrease	VBD
cord-299731-sis9952k	86	4	levels	level	NNS
cord-299731-sis9952k	86	5	of	of	IN
cord-299731-sis9952k	86	6	hepatic	hepatic	JJ
cord-299731-sis9952k	86	7	NADP	NADP	NNP
cord-299731-sis9952k	86	8	+	+	SYM
cord-299731-sis9952k	86	9	and	and	CC
cord-299731-sis9952k	86	10	NADPH	NADPH	NNP
cord-299731-sis9952k	86	11	in	in	IN
cord-299731-sis9952k	86	12	PD	PD	NNP
cord-299731-sis9952k	86	13	and	and	CC
cord-299731-sis9952k	86	14	T2D	t2d	CD
cord-299731-sis9952k	86	15	mice	mouse	NNS
cord-299731-sis9952k	86	16	are	be	VBP
cord-299731-sis9952k	86	17	restored	restore	VBN
cord-299731-sis9952k	86	18	with	with	IN
cord-299731-sis9952k	86	19	supplementation	supplementation	NN
cord-299731-sis9952k	86	20	of	of	IN
cord-299731-sis9952k	86	21	NR	NR	NNP
cord-299731-sis9952k	86	22	[	[	-LRB-
cord-299731-sis9952k	86	23	41	41	CD
cord-299731-sis9952k	86	24	]	]	-RRB-
cord-299731-sis9952k	86	25	.	.	.
cord-299731-sis9952k	87	1	In	in	IN
cord-299731-sis9952k	87	2	mice	mouse	NNS
cord-299731-sis9952k	87	3	models	model	NNS
cord-299731-sis9952k	87	4	,	,	,
cord-299731-sis9952k	87	5	NR	NR	NNP
cord-299731-sis9952k	87	6	can	can	MD
cord-299731-sis9952k	87	7	increase	increase	VB
cord-299731-sis9952k	87	8	NAD	NAD	NNP
cord-299731-sis9952k	87	9	+	+	CC
cord-299731-sis9952k	87	10	metabolism	metabolism	NN
cord-299731-sis9952k	87	11	and	and	CC
cord-299731-sis9952k	87	12	thereby	thereby	RB
cord-299731-sis9952k	87	13	improve	improve	VB
cord-299731-sis9952k	87	14	glucose	glucose	NN
cord-299731-sis9952k	87	15	tolerance	tolerance	NN
cord-299731-sis9952k	87	16	,	,	,
cord-299731-sis9952k	87	17	reduce	reduce	VB
cord-299731-sis9952k	87	18	weight	weight	NN
cord-299731-sis9952k	87	19	gain	gain	NN
cord-299731-sis9952k	87	20	,	,	,
cord-299731-sis9952k	87	21	and	and	CC
cord-299731-sis9952k	87	22	exhibit	exhibit	VB
cord-299731-sis9952k	87	23	neuroprotective	neuroprotective	JJ
cord-299731-sis9952k	87	24	effects	effect	NNS
cord-299731-sis9952k	87	25	against	against	IN
cord-299731-sis9952k	87	26	diabetic	diabetic	JJ
cord-299731-sis9952k	87	27	neuropathy	neuropathy	NN
cord-299731-sis9952k	87	28	and	and	CC
cord-299731-sis9952k	87	29	liver	liver	NN
cord-299731-sis9952k	87	30	steatosis	steatosis	NN
cord-299731-sis9952k	87	31	[	[	-LRB-
cord-299731-sis9952k	87	32	41	41	CD
cord-299731-sis9952k	87	33	]	]	-RRB-
cord-299731-sis9952k	87	34	.	.	.
cord-299731-sis9952k	88	1	Similarly	similarly	RB
cord-299731-sis9952k	88	2	,	,	,
cord-299731-sis9952k	88	3	in	in	IN
cord-299731-sis9952k	88	4	mice	mice	NN
cord-299731-sis9952k	88	5	models	model	NNS
cord-299731-sis9952k	88	6	of	of	IN
cord-299731-sis9952k	88	7	high	high	JJ
cord-299731-sis9952k	88	8	-	-	HYPH
cord-299731-sis9952k	88	9	fat	fat	NN
cord-299731-sis9952k	88	10	-	-	HYPH
cord-299731-sis9952k	88	11	induced	induce	VBN
cord-299731-sis9952k	88	12	obesity	obesity	NN
cord-299731-sis9952k	88	13	,	,	,
cord-299731-sis9952k	88	14	a	a	DT
cord-299731-sis9952k	88	15	dose	dose	NN
cord-299731-sis9952k	88	16	of	of	IN
cord-299731-sis9952k	88	17	dietary	dietary	JJ
cord-299731-sis9952k	88	18	NR	NR	NNP
cord-299731-sis9952k	88	19	as	as	RB
cord-299731-sis9952k	88	20	small	small	JJ
cord-299731-sis9952k	88	21	as	as	IN
cord-299731-sis9952k	88	22	400	400	CD
cord-299731-sis9952k	88	23	mg	mg	NNP
cord-299731-sis9952k	88	24	/	/	SYM
cord-299731-sis9952k	88	25	kg	kg	NNP
cord-299731-sis9952k	88	26	/	/	SYM
cord-299731-sis9952k	88	27	day	day	NN
cord-299731-sis9952k	88	28	was	be	VBD
cord-299731-sis9952k	88	29	shown	show	VBN
cord-299731-sis9952k	88	30	to	to	TO
cord-299731-sis9952k	88	31	improve	improve	VB
cord-299731-sis9952k	88	32	insulin	insulin	NN
cord-299731-sis9952k	88	33	sensitivity	sensitivity	NN
cord-299731-sis9952k	88	34	and	and	CC
cord-299731-sis9952k	88	35	protect	protect	VB
cord-299731-sis9952k	88	36	mice	mouse	NNS
cord-299731-sis9952k	88	37	from	from	IN
cord-299731-sis9952k	88	38	weight	weight	NN
cord-299731-sis9952k	88	39	gain	gain	NN
cord-299731-sis9952k	88	40	[	[	-LRB-
cord-299731-sis9952k	88	41	37	37	CD
cord-299731-sis9952k	88	42	]	]	-RRB-
cord-299731-sis9952k	88	43	.	.	.
cord-299731-sis9952k	89	1	However	however	RB
cord-299731-sis9952k	89	2	,	,	,
cord-299731-sis9952k	89	3	these	these	DT
cord-299731-sis9952k	89	4	results	result	NNS
cord-299731-sis9952k	89	5	have	have	VBP
cord-299731-sis9952k	89	6	not	not	RB
cord-299731-sis9952k	89	7	yet	yet	RB
cord-299731-sis9952k	89	8	been	be	VBN
cord-299731-sis9952k	89	9	replicated	replicate	VBN
cord-299731-sis9952k	89	10	in	in	IN
cord-299731-sis9952k	89	11	humans	human	NNS
cord-299731-sis9952k	89	12	,	,	,
cord-299731-sis9952k	89	13	as	as	IN
cord-299731-sis9952k	89	14	12-week	12-week	JJ
cord-299731-sis9952k	89	15	supplementation	supplementation	NN
cord-299731-sis9952k	89	16	of	of	IN
cord-299731-sis9952k	89	17	NR	NR	NNP
cord-299731-sis9952k	89	18	with	with	IN
cord-299731-sis9952k	89	19	a	a	DT
cord-299731-sis9952k	89	20	dose	dose	NN
cord-299731-sis9952k	89	21	of	of	IN
cord-299731-sis9952k	89	22	2000	2000	CD
cord-299731-sis9952k	89	23	mg	mg	NNP
cord-299731-sis9952k	89	24	/	/	SYM
cord-299731-sis9952k	89	25	day	day	NN
cord-299731-sis9952k	89	26	was	be	VBD
cord-299731-sis9952k	89	27	not	not	RB
cord-299731-sis9952k	89	28	able	able	JJ
cord-299731-sis9952k	89	29	to	to	TO
cord-299731-sis9952k	89	30	improve	improve	VB
cord-299731-sis9952k	89	31	insulin	insulin	NN
cord-299731-sis9952k	89	32	sensitivity	sensitivity	NN
cord-299731-sis9952k	89	33	and	and	CC
cord-299731-sis9952k	89	34	other	other	JJ
cord-299731-sis9952k	89	35	metabolic	metabolic	JJ
cord-299731-sis9952k	89	36	parameters	parameter	NNS
cord-299731-sis9952k	89	37	in	in	IN
cord-299731-sis9952k	89	38	insulin	insulin	NN
cord-299731-sis9952k	89	39	-	-	HYPH
cord-299731-sis9952k	89	40	resistant	resistant	JJ
cord-299731-sis9952k	89	41	,	,	,
cord-299731-sis9952k	89	42	obese	obese	JJ
cord-299731-sis9952k	89	43	men	man	NNS
cord-299731-sis9952k	89	44	[	[	-LRB-
cord-299731-sis9952k	89	45	43	43	CD
cord-299731-sis9952k	89	46	]	]	-RRB-
cord-299731-sis9952k	89	47	.	.	.
cord-299731-sis9952k	90	1	Additional	additional	JJ
cord-299731-sis9952k	90	2	research	research	NN
cord-299731-sis9952k	90	3	is	be	VBZ
cord-299731-sis9952k	90	4	required	require	VBN
cord-299731-sis9952k	90	5	to	to	TO
cord-299731-sis9952k	90	6	determine	determine	VB
cord-299731-sis9952k	90	7	the	the	DT
cord-299731-sis9952k	90	8	long	long	JJ
cord-299731-sis9952k	90	9	-	-	HYPH
cord-299731-sis9952k	90	10	term	term	NN
cord-299731-sis9952k	90	11	effects	effect	NNS
cord-299731-sis9952k	90	12	of	of	IN
cord-299731-sis9952k	90	13	NR	nr	NN
cord-299731-sis9952k	90	14	on	on	IN
cord-299731-sis9952k	90	15	insulin	insulin	NN
cord-299731-sis9952k	90	16	sensitivity	sensitivity	NN
cord-299731-sis9952k	90	17	[	[	-LRB-
cord-299731-sis9952k	90	18	43	43	CD
cord-299731-sis9952k	90	19	]	]	-RRB-
cord-299731-sis9952k	90	20	.	.	.
cord-299731-sis9952k	91	1	On	on	IN
cord-299731-sis9952k	91	2	the	the	DT
cord-299731-sis9952k	91	3	other	other	JJ
cord-299731-sis9952k	91	4	hand	hand	NN
cord-299731-sis9952k	91	5	,	,	,
cord-299731-sis9952k	91	6	there	there	EX
cord-299731-sis9952k	91	7	is	be	VBZ
cord-299731-sis9952k	91	8	evidence	evidence	NN
cord-299731-sis9952k	91	9	that	that	IN
cord-299731-sis9952k	91	10	NR	NR	NNP
cord-299731-sis9952k	91	11	administration	administration	NN
cord-299731-sis9952k	91	12	in	in	IN
cord-299731-sis9952k	91	13	mice	mouse	NNS
cord-299731-sis9952k	91	14	models	model	NNS
cord-299731-sis9952k	91	15	increases	increase	VBZ
cord-299731-sis9952k	91	16	the	the	DT
cord-299731-sis9952k	91	17	activity	activity	NN
cord-299731-sis9952k	91	18	of	of	IN
cord-299731-sis9952k	91	19	SIRT1	sirt1	NN
cord-299731-sis9952k	91	20	,	,	,
cord-299731-sis9952k	91	21	an	an	DT
cord-299731-sis9952k	91	22	important	important	JJ
cord-299731-sis9952k	91	23	factor	factor	NN
cord-299731-sis9952k	91	24	in	in	IN
cord-299731-sis9952k	91	25	the	the	DT
cord-299731-sis9952k	91	26	prevention	prevention	NN
cord-299731-sis9952k	91	27	of	of	IN
cord-299731-sis9952k	91	28	T2D	t2d	CD
cord-299731-sis9952k	91	29	and	and	CC
cord-299731-sis9952k	91	30	preservation	preservation	NN
cord-299731-sis9952k	91	31	of	of	IN
cord-299731-sis9952k	91	32	insulin	insulin	NN
cord-299731-sis9952k	91	33	sensitivity	sensitivity	NN
cord-299731-sis9952k	91	34	[	[	-LRB-
cord-299731-sis9952k	91	35	37	37	CD
cord-299731-sis9952k	91	36	,	,	,
cord-299731-sis9952k	91	37	44	44	CD
cord-299731-sis9952k	91	38	]	]	-RRB-
cord-299731-sis9952k	91	39	.	.	.
cord-299731-sis9952k	92	1	Moreover	moreover	RB
cord-299731-sis9952k	92	2	,	,	,
cord-299731-sis9952k	92	3	SIRT1	SIRT1	NNP
cord-299731-sis9952k	92	4	inhibits	inhibit	VBZ
cord-299731-sis9952k	92	5	effects	effect	NNS
cord-299731-sis9952k	92	6	of	of	IN
cord-299731-sis9952k	92	7	oxidative	oxidative	JJ
cord-299731-sis9952k	92	8	stress	stress	NN
cord-299731-sis9952k	92	9	in	in	IN
cord-299731-sis9952k	92	10	T2D	t2d	CD
cord-299731-sis9952k	92	11	mice	mouse	NNS
cord-299731-sis9952k	92	12	[	[	-LRB-
cord-299731-sis9952k	92	13	45	45	CD
cord-299731-sis9952k	92	14	]	]	-RRB-
cord-299731-sis9952k	92	15	,	,	,
cord-299731-sis9952k	92	16	promotes	promote	VBZ
cord-299731-sis9952k	92	17	glucose	glucose	NN
cord-299731-sis9952k	92	18	-	-	HYPH
cord-299731-sis9952k	92	19	stimulated	stimulate	VBN
cord-299731-sis9952k	92	20	insulin	insulin	NN
cord-299731-sis9952k	92	21	secretion	secretion	NN
cord-299731-sis9952k	92	22	from	from	IN
cord-299731-sis9952k	92	23	pancreatic	pancreatic	JJ
cord-299731-sis9952k	92	24	β	β	NN
cord-299731-sis9952k	92	25	-	-	HYPH
cord-299731-sis9952k	92	26	cells	cell	NNS
cord-299731-sis9952k	92	27	[	[	-LRB-
cord-299731-sis9952k	92	28	46	46	CD
cord-299731-sis9952k	92	29	,	,	,
cord-299731-sis9952k	92	30	47	47	CD
cord-299731-sis9952k	92	31	]	]	-RRB-
cord-299731-sis9952k	92	32	,	,	,
cord-299731-sis9952k	92	33	and	and	CC
cord-299731-sis9952k	92	34	protects	protect	VBZ
cord-299731-sis9952k	92	35	against	against	IN
cord-299731-sis9952k	92	36	insulin	insulin	NN
cord-299731-sis9952k	92	37	resistance	resistance	NN
cord-299731-sis9952k	92	38	in	in	IN
cord-299731-sis9952k	92	39	peripheral	peripheral	JJ
cord-299731-sis9952k	92	40	tissues	tissue	NNS
cord-299731-sis9952k	92	41	[	[	-LRB-
cord-299731-sis9952k	92	42	48	48	CD
cord-299731-sis9952k	92	43	]	]	-RRB-
cord-299731-sis9952k	92	44	,	,	,
cord-299731-sis9952k	92	45	whilst	whilst	IN
cord-299731-sis9952k	92	46	SIRT1	SIRT1	NNP
cord-299731-sis9952k	92	47	overexpression	overexpression	NN
cord-299731-sis9952k	92	48	promotes	promote	VBZ
cord-299731-sis9952k	92	49	fatty	fatty	JJ
cord-299731-sis9952k	92	50	acid	acid	NN
cord-299731-sis9952k	92	51	oxidation	oxidation	NN
cord-299731-sis9952k	92	52	and	and	CC
cord-299731-sis9952k	92	53	inhibits	inhibit	VBZ
cord-299731-sis9952k	92	54	lipogenesis	lipogenesi	NNS
cord-299731-sis9952k	92	55	,	,	,
cord-299731-sis9952k	92	56	protecting	protect	VBG
cord-299731-sis9952k	92	57	the	the	DT
cord-299731-sis9952k	92	58	liver	liver	NN
cord-299731-sis9952k	92	59	from	from	IN
cord-299731-sis9952k	92	60	steatosis	steatosis	NN
cord-299731-sis9952k	92	61	.	.	.
cord-299731-sis9952k	93	1	In	in	IN
cord-299731-sis9952k	93	2	addition	addition	NN
cord-299731-sis9952k	93	3	,	,	,
cord-299731-sis9952k	93	4	sirtuins	sirtuin	NNS
cord-299731-sis9952k	93	5	are	be	VBP
cord-299731-sis9952k	93	6	downregulated	downregulate	VBN
cord-299731-sis9952k	93	7	in	in	IN
cord-299731-sis9952k	93	8	NAFLD	NAFLD	NNP
cord-299731-sis9952k	93	9	patients	patient	NNS
cord-299731-sis9952k	93	10	,	,	,
cord-299731-sis9952k	93	11	a	a	DT
cord-299731-sis9952k	93	12	state	state	NN
cord-299731-sis9952k	93	13	characterized	characterize	VBN
cord-299731-sis9952k	93	14	by	by	IN
cord-299731-sis9952k	93	15	liver	liver	NN
cord-299731-sis9952k	93	16	steatosis	steatosis	NN
cord-299731-sis9952k	93	17	[	[	-LRB-
cord-299731-sis9952k	93	18	49	49	CD
cord-299731-sis9952k	93	19	]	]	-RRB-
cord-299731-sis9952k	93	20	.	.	.
cord-299731-sis9952k	94	1	NAFLD	NAFLD	NNP
cord-299731-sis9952k	94	2	is	be	VBZ
cord-299731-sis9952k	94	3	widely	widely	RB
cord-299731-sis9952k	94	4	considered	consider	VBN
cord-299731-sis9952k	94	5	a	a	DT
cord-299731-sis9952k	94	6	hepatic	hepatic	JJ
cord-299731-sis9952k	94	7	manifestation	manifestation	NN
cord-299731-sis9952k	94	8	of	of	IN
cord-299731-sis9952k	94	9	metabolic	metabolic	JJ
cord-299731-sis9952k	94	10	syndrome	syndrome	NN
cord-299731-sis9952k	94	11	as	as	IN
cord-299731-sis9952k	94	12	it	-PRON-	PRP
cord-299731-sis9952k	94	13	is	be	VBZ
cord-299731-sis9952k	94	14	found	find	VBN
cord-299731-sis9952k	94	15	to	to	TO
cord-299731-sis9952k	94	16	be	be	VB
cord-299731-sis9952k	94	17	associated	associate	VBN
cord-299731-sis9952k	94	18	with	with	IN
cord-299731-sis9952k	94	19	T2D	t2d	CD
cord-299731-sis9952k	94	20	,	,	,
cord-299731-sis9952k	94	21	obesity	obesity	NN
cord-299731-sis9952k	94	22	,	,	,
cord-299731-sis9952k	94	23	and	and	CC
cord-299731-sis9952k	94	24	insulin	insulin	NN
cord-299731-sis9952k	94	25	resistance	resistance	NN
cord-299731-sis9952k	94	26	[	[	-LRB-
cord-299731-sis9952k	94	27	50	50	CD
cord-299731-sis9952k	94	28	]	]	-RRB-
cord-299731-sis9952k	94	29	.	.	.
cord-299731-sis9952k	95	1	Via	via	IN
cord-299731-sis9952k	95	2	activation	activation	NN
cord-299731-sis9952k	95	3	of	of	IN
cord-299731-sis9952k	95	4	SIRT1	sirt1	NN
cord-299731-sis9952k	95	5	and	and	CC
cord-299731-sis9952k	95	6	additional	additional	JJ
cord-299731-sis9952k	95	7	factors	factor	NNS
cord-299731-sis9952k	95	8	associated	associate	VBN
cord-299731-sis9952k	95	9	with	with	IN
cord-299731-sis9952k	95	10	cholesterol	cholesterol	NN
cord-299731-sis9952k	95	11	homeostasis	homeostasis	NN
cord-299731-sis9952k	95	12	,	,	,
cord-299731-sis9952k	95	13	NR	NR	NNP
cord-299731-sis9952k	95	14	could	could	MD
cord-299731-sis9952k	95	15	potentially	potentially	RB
cord-299731-sis9952k	95	16	reduce	reduce	VB
cord-299731-sis9952k	95	17	cholesterol	cholesterol	NN
cord-299731-sis9952k	95	18	levels	level	NNS
cord-299731-sis9952k	95	19	and	and	CC
cord-299731-sis9952k	95	20	improve	improve	VB
cord-299731-sis9952k	95	21	liver	liver	NN
cord-299731-sis9952k	95	22	health	health	NN
cord-299731-sis9952k	95	23	[	[	-LRB-
cord-299731-sis9952k	95	24	51	51	CD
cord-299731-sis9952k	95	25	]	]	-RRB-
cord-299731-sis9952k	96	1	[	[	-LRB-
cord-299731-sis9952k	96	2	52	52	CD
cord-299731-sis9952k	96	3	]	]	-RRB-
cord-299731-sis9952k	97	1	[	[	-LRB-
cord-299731-sis9952k	97	2	53	53	CD
cord-299731-sis9952k	97	3	]	]	-RRB-
cord-299731-sis9952k	97	4	[	[	-LRB-
cord-299731-sis9952k	97	5	54	54	CD
cord-299731-sis9952k	97	6	]	]	-RRB-
cord-299731-sis9952k	97	7	.	.	.
cord-299731-sis9952k	98	1	Fat	fat	JJ
cord-299731-sis9952k	98	2	accumulation	accumulation	NN
cord-299731-sis9952k	98	3	is	be	VBZ
cord-299731-sis9952k	98	4	also	also	RB
cord-299731-sis9952k	98	5	potentially	potentially	RB
cord-299731-sis9952k	98	6	reduced	reduce	VBN
cord-299731-sis9952k	98	7	through	through	IN
cord-299731-sis9952k	98	8	a	a	DT
cord-299731-sis9952k	98	9	mechanism	mechanism	NN
cord-299731-sis9952k	98	10	that	that	WDT
cord-299731-sis9952k	98	11	involves	involve	VBZ
cord-299731-sis9952k	98	12	the	the	DT
cord-299731-sis9952k	98	13	induction	induction	NN
cord-299731-sis9952k	98	14	of	of	IN
cord-299731-sis9952k	98	15	the	the	DT
cord-299731-sis9952k	98	16	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	98	17	unfolded	unfold	VBD
cord-299731-sis9952k	98	18	protein	protein	NN
cord-299731-sis9952k	98	19	response	response	NN
cord-299731-sis9952k	98	20	[	[	-LRB-
cord-299731-sis9952k	98	21	44	44	CD
cord-299731-sis9952k	98	22	]	]	-RRB-
cord-299731-sis9952k	98	23	.	.	.
cord-299731-sis9952k	99	1	In	in	IN
cord-299731-sis9952k	99	2	regenerating	regenerate	VBG
cord-299731-sis9952k	99	3	liver	liver	NN
cord-299731-sis9952k	99	4	,	,	,
cord-299731-sis9952k	99	5	NR	NR	NNP
cord-299731-sis9952k	99	6	reduces	reduce	VBZ
cord-299731-sis9952k	99	7	lipid	lipid	NN
cord-299731-sis9952k	99	8	accumulation	accumulation	NN
cord-299731-sis9952k	99	9	,	,	,
cord-299731-sis9952k	99	10	promotes	promote	VBZ
cord-299731-sis9952k	99	11	hepatocyte	hepatocyte	NN
cord-299731-sis9952k	99	12	replication	replication	NN
cord-299731-sis9952k	99	13	,	,	,
cord-299731-sis9952k	99	14	and	and	CC
cord-299731-sis9952k	99	15	increases	increase	VBZ
cord-299731-sis9952k	99	16	hepatic	hepatic	JJ
cord-299731-sis9952k	99	17	ATP	ATP	NNP
cord-299731-sis9952k	99	18	content	content	NN
cord-299731-sis9952k	99	19	leading	lead	VBG
cord-299731-sis9952k	99	20	to	to	IN
cord-299731-sis9952k	99	21	a	a	DT
cord-299731-sis9952k	99	22	faster	fast	JJR
cord-299731-sis9952k	99	23	regaining	regaining	NN
cord-299731-sis9952k	99	24	of	of	IN
cord-299731-sis9952k	99	25	liver	liver	NN
cord-299731-sis9952k	99	26	weight	weight	NN
cord-299731-sis9952k	99	27	in	in	IN
cord-299731-sis9952k	99	28	mice	mouse	NNS
cord-299731-sis9952k	99	29	[	[	-LRB-
cord-299731-sis9952k	99	30	55	55	CD
cord-299731-sis9952k	99	31	]	]	-RRB-
cord-299731-sis9952k	99	32	.	.	.
cord-299731-sis9952k	100	1	Moreover	moreover	RB
cord-299731-sis9952k	100	2	,	,	,
cord-299731-sis9952k	100	3	dietary	dietary	JJ
cord-299731-sis9952k	100	4	supplementation	supplementation	NN
cord-299731-sis9952k	100	5	of	of	IN
cord-299731-sis9952k	100	6	NR	NR	NNP
cord-299731-sis9952k	100	7	was	be	VBD
cord-299731-sis9952k	100	8	able	able	JJ
cord-299731-sis9952k	100	9	to	to	TO
cord-299731-sis9952k	100	10	restore	restore	VB
cord-299731-sis9952k	100	11	NAD	NAD	NNP
cord-299731-sis9952k	101	1	+	+	CC
cord-299731-sis9952k	101	2	levels	level	NNS
cord-299731-sis9952k	101	3	caused	cause	VBN
cord-299731-sis9952k	101	4	by	by	IN
cord-299731-sis9952k	101	5	impaired	impaired	JJ
cord-299731-sis9952k	101	6	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	101	7	in	in	IN
cord-299731-sis9952k	101	8	a	a	DT
cord-299731-sis9952k	101	9	mouse	mouse	NN
cord-299731-sis9952k	101	10	model	model	NN
cord-299731-sis9952k	101	11	of	of	IN
cord-299731-sis9952k	101	12	hepatocellular	hepatocellular	JJ
cord-299731-sis9952k	101	13	carcinoma	carcinoma	NN
cord-299731-sis9952k	101	14	,	,	,
cord-299731-sis9952k	101	15	and	and	CC
cord-299731-sis9952k	101	16	thereby	thereby	RB
cord-299731-sis9952k	101	17	prevent	prevent	VB
cord-299731-sis9952k	101	18	both	both	CC
cord-299731-sis9952k	101	19	DNA	dna	NN
cord-299731-sis9952k	101	20	damage	damage	NN
cord-299731-sis9952k	101	21	and	and	CC
cord-299731-sis9952k	101	22	tumorigenesis	tumorigenesis	NN
cord-299731-sis9952k	101	23	[	[	-LRB-
cord-299731-sis9952k	101	24	56	56	CD
cord-299731-sis9952k	101	25	]	]	-RRB-
cord-299731-sis9952k	101	26	.	.	.
cord-299731-sis9952k	102	1	Altogether	altogether	RB
cord-299731-sis9952k	102	2	,	,	,
cord-299731-sis9952k	102	3	there	there	EX
cord-299731-sis9952k	102	4	is	be	VBZ
cord-299731-sis9952k	102	5	sufficient	sufficient	JJ
cord-299731-sis9952k	102	6	evidence	evidence	NN
cord-299731-sis9952k	102	7	indicating	indicate	VBG
cord-299731-sis9952k	102	8	that	that	IN
cord-299731-sis9952k	102	9	increasing	increase	VBG
cord-299731-sis9952k	102	10	NAD	NAD	NNP
cord-299731-sis9952k	102	11	+	+	CC
cord-299731-sis9952k	102	12	content	content	NN
cord-299731-sis9952k	102	13	with	with	IN
cord-299731-sis9952k	102	14	NR	NR	NNP
cord-299731-sis9952k	102	15	supplementation	supplementation	NN
cord-299731-sis9952k	102	16	can	can	MD
cord-299731-sis9952k	102	17	be	be	VB
cord-299731-sis9952k	102	18	considered	consider	VBN
cord-299731-sis9952k	102	19	a	a	DT
cord-299731-sis9952k	102	20	promising	promising	JJ
cord-299731-sis9952k	102	21	therapeutic	therapeutic	JJ
cord-299731-sis9952k	102	22	strategy	strategy	NN
cord-299731-sis9952k	102	23	for	for	IN
cord-299731-sis9952k	102	24	metabolic	metabolic	JJ
cord-299731-sis9952k	102	25	dysfunctions	dysfunction	NNS
cord-299731-sis9952k	102	26	,	,	,
cord-299731-sis9952k	102	27	including	include	VBG
cord-299731-sis9952k	102	28	T2D	t2d	CD
cord-299731-sis9952k	102	29	and	and	CC
cord-299731-sis9952k	102	30	NAFLD	NAFLD	NNP
cord-299731-sis9952k	102	31	.	.	.
cord-299731-sis9952k	103	1	Disruption	disruption	NN
cord-299731-sis9952k	103	2	of	of	IN
cord-299731-sis9952k	103	3	NAD	NAD	NNP
cord-299731-sis9952k	103	4	+	+	CC
cord-299731-sis9952k	103	5	homeostasis	homeostasis	NN
cord-299731-sis9952k	103	6	due	due	IN
cord-299731-sis9952k	103	7	to	to	IN
cord-299731-sis9952k	103	8	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	103	9	dysfunction	dysfunction	NN
cord-299731-sis9952k	103	10	is	be	VBZ
cord-299731-sis9952k	103	11	central	central	JJ
cord-299731-sis9952k	103	12	in	in	IN
cord-299731-sis9952k	103	13	the	the	DT
cord-299731-sis9952k	103	14	development	development	NN
cord-299731-sis9952k	103	15	of	of	IN
cord-299731-sis9952k	103	16	cardiac	cardiac	JJ
cord-299731-sis9952k	103	17	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	103	18	and	and	CC
cord-299731-sis9952k	103	19	heart	heart	NN
cord-299731-sis9952k	103	20	failure	failure	NN
cord-299731-sis9952k	103	21	(	(	-LRB-
cord-299731-sis9952k	103	22	HF	HF	NNP
cord-299731-sis9952k	103	23	)	)	-RRB-
cord-299731-sis9952k	103	24	and	and	CC
cord-299731-sis9952k	103	25	has	have	VBZ
cord-299731-sis9952k	103	26	been	be	VBN
cord-299731-sis9952k	103	27	reported	report	VBN
cord-299731-sis9952k	103	28	in	in	IN
cord-299731-sis9952k	103	29	several	several	JJ
cord-299731-sis9952k	103	30	models	model	NNS
cord-299731-sis9952k	103	31	of	of	IN
cord-299731-sis9952k	103	32	HF	HF	NNP
cord-299731-sis9952k	103	33	including	include	VBG
cord-299731-sis9952k	103	34	pressure	pressure	NN
cord-299731-sis9952k	103	35	overload	overload	NN
cord-299731-sis9952k	103	36	,	,	,
cord-299731-sis9952k	103	37	myocardial	myocardial	JJ
cord-299731-sis9952k	103	38	infarction	infarction	NN
cord-299731-sis9952k	103	39	,	,	,
cord-299731-sis9952k	103	40	and	and	CC
cord-299731-sis9952k	103	41	angiotensin	angiotensin	NN
cord-299731-sis9952k	103	42	II	ii	CD
cord-299731-sis9952k	103	43	infusion	infusion	NN
cord-299731-sis9952k	103	44	[	[	-LRB-
cord-299731-sis9952k	103	45	57	57	CD
cord-299731-sis9952k	103	46	]	]	-RRB-
cord-299731-sis9952k	104	1	[	[	-LRB-
cord-299731-sis9952k	104	2	58	58	CD
cord-299731-sis9952k	104	3	]	]	-RRB-
cord-299731-sis9952k	105	1	[	[	-LRB-
cord-299731-sis9952k	105	2	59	59	CD
cord-299731-sis9952k	105	3	]	]	-RRB-
cord-299731-sis9952k	105	4	[	[	-LRB-
cord-299731-sis9952k	105	5	60	60	CD
cord-299731-sis9952k	105	6	]	]	-RRB-
cord-299731-sis9952k	105	7	[	[	-LRB-
cord-299731-sis9952k	105	8	61	61	CD
cord-299731-sis9952k	105	9	]	]	-RRB-
cord-299731-sis9952k	105	10	[	[	-LRB-
cord-299731-sis9952k	105	11	62	62	CD
cord-299731-sis9952k	105	12	]	]	-RRB-
cord-299731-sis9952k	105	13	.	.	.
cord-299731-sis9952k	106	1	Furthermore	furthermore	RB
cord-299731-sis9952k	106	2	,	,	,
cord-299731-sis9952k	106	3	a	a	DT
cord-299731-sis9952k	106	4	shift	shift	NN
cord-299731-sis9952k	106	5	from	from	IN
cord-299731-sis9952k	106	6	fatty	fatty	JJ
cord-299731-sis9952k	106	7	acid	acid	NN
cord-299731-sis9952k	106	8	oxidation	oxidation	NN
cord-299731-sis9952k	106	9	and	and	CC
cord-299731-sis9952k	106	10	oxidative	oxidative	JJ
cord-299731-sis9952k	106	11	phosphorylation	phosphorylation	NN
cord-299731-sis9952k	106	12	to	to	IN
cord-299731-sis9952k	106	13	other	other	JJ
cord-299731-sis9952k	106	14	forms	form	NNS
cord-299731-sis9952k	106	15	of	of	IN
cord-299731-sis9952k	106	16	substrate	substrate	NN
cord-299731-sis9952k	106	17	metabolism	metabolism	NN
cord-299731-sis9952k	106	18	(	(	-LRB-
cord-299731-sis9952k	106	19	glycolysis	glycolysis	NN
cord-299731-sis9952k	106	20	and	and	CC
cord-299731-sis9952k	106	21	ketone	ketone	NN
cord-299731-sis9952k	106	22	oxidation	oxidation	NN
cord-299731-sis9952k	106	23	)	)	-RRB-
cord-299731-sis9952k	106	24	often	often	RB
cord-299731-sis9952k	106	25	occurs	occur	VBZ
cord-299731-sis9952k	106	26	in	in	IN
cord-299731-sis9952k	106	27	the	the	DT
cord-299731-sis9952k	106	28	development	development	NN
cord-299731-sis9952k	106	29	of	of	IN
cord-299731-sis9952k	106	30	HF	HF	NNP
cord-299731-sis9952k	106	31	[	[	-LRB-
cord-299731-sis9952k	106	32	63	63	CD
cord-299731-sis9952k	106	33	,	,	,
cord-299731-sis9952k	106	34	64	64	CD
cord-299731-sis9952k	106	35	]	]	-RRB-
cord-299731-sis9952k	106	36	,	,	,
cord-299731-sis9952k	106	37	while	while	IN
cord-299731-sis9952k	106	38	the	the	DT
cord-299731-sis9952k	106	39	NAD	NAD	NNP
cord-299731-sis9952k	106	40	+	+	CC
cord-299731-sis9952k	106	41	/NADH	/nadh	SYM
cord-299731-sis9952k	106	42	ratio	ratio	NN
cord-299731-sis9952k	106	43	also	also	RB
cord-299731-sis9952k	106	44	decreases	decrease	VBZ
cord-299731-sis9952k	106	45	[	[	-LRB-
cord-299731-sis9952k	106	46	64	64	CD
cord-299731-sis9952k	106	47	]	]	-RRB-
cord-299731-sis9952k	106	48	.	.	.
cord-299731-sis9952k	107	1	The	the	DT
cord-299731-sis9952k	107	2	change	change	NN
cord-299731-sis9952k	107	3	in	in	IN
cord-299731-sis9952k	107	4	oxidative	oxidative	JJ
cord-299731-sis9952k	107	5	-	-	HYPH
cord-299731-sis9952k	107	6	reductive	reductive	JJ
cord-299731-sis9952k	107	7	capacity	capacity	NN
cord-299731-sis9952k	107	8	further	far	RBR
cord-299731-sis9952k	107	9	increases	increase	VBZ
cord-299731-sis9952k	107	10	cardiac	cardiac	JJ
cord-299731-sis9952k	107	11	susceptibility	susceptibility	NN
cord-299731-sis9952k	107	12	to	to	TO
cord-299731-sis9952k	107	13	stress	stress	VB
cord-299731-sis9952k	107	14	.	.	.
cord-299731-sis9952k	108	1	The	the	DT
cord-299731-sis9952k	108	2	level	level	NN
cord-299731-sis9952k	108	3	of	of	IN
cord-299731-sis9952k	108	4	protein	protein	NN
cord-299731-sis9952k	108	5	hyperacetylation	hyperacetylation	NN
cord-299731-sis9952k	108	6	also	also	RB
cord-299731-sis9952k	108	7	increases	increase	VBZ
cord-299731-sis9952k	108	8	,	,	,
cord-299731-sis9952k	108	9	driven	drive	VBN
cord-299731-sis9952k	108	10	by	by	IN
cord-299731-sis9952k	108	11	decreasing	decrease	VBG
cord-299731-sis9952k	108	12	NAD	NAD	NNP
cord-299731-sis9952k	108	13	+	+	CC
cord-299731-sis9952k	109	1	-dependent	-dependent	JJ
cord-299731-sis9952k	109	2	deacetylation	deacetylation	NNP
cord-299731-sis9952k	109	3	both	both	CC
cord-299731-sis9952k	109	4	in	in	IN
cord-299731-sis9952k	109	5	mouse	mouse	NN
cord-299731-sis9952k	109	6	models	model	NNS
cord-299731-sis9952k	109	7	of	of	IN
cord-299731-sis9952k	109	8	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	109	9	and	and	CC
cord-299731-sis9952k	109	10	in	in	IN
cord-299731-sis9952k	109	11	human	human	JJ
cord-299731-sis9952k	109	12	patients	patient	NNS
cord-299731-sis9952k	109	13	with	with	IN
cord-299731-sis9952k	109	14	ischemic	ischemic	JJ
cord-299731-sis9952k	109	15	HF	HF	NNP
cord-299731-sis9952k	109	16	or	or	CC
cord-299731-sis9952k	109	17	dilated	dilate	VBN
cord-299731-sis9952k	109	18	cardiomyopathy	cardiomyopathy	NN
cord-299731-sis9952k	109	19	(	(	-LRB-
cord-299731-sis9952k	109	20	DCM	DCM	NNP
cord-299731-sis9952k	109	21	)	)	-RRB-
cord-299731-sis9952k	109	22	[	[	-LRB-
cord-299731-sis9952k	109	23	64	64	CD
cord-299731-sis9952k	109	24	,	,	,
cord-299731-sis9952k	109	25	65	65	CD
cord-299731-sis9952k	109	26	]	]	-RRB-
cord-299731-sis9952k	109	27	.	.	.
cord-299731-sis9952k	110	1	NR	NR	NNP
cord-299731-sis9952k	110	2	supplementation	supplementation	NN
cord-299731-sis9952k	110	3	normalizes	normalize	VBZ
cord-299731-sis9952k	110	4	the	the	DT
cord-299731-sis9952k	110	5	myocardial	myocardial	JJ
cord-299731-sis9952k	110	6	NAD	NAD	NNP
cord-299731-sis9952k	110	7	+	+	CC
cord-299731-sis9952k	110	8	/NADH	/NADH	.
cord-299731-sis9952k	111	1	ratio	ratio	NN
cord-299731-sis9952k	111	2	and	and	CC
cord-299731-sis9952k	111	3	exhibits	exhibit	VBZ
cord-299731-sis9952k	111	4	protective	protective	JJ
cord-299731-sis9952k	111	5	effects	effect	NNS
cord-299731-sis9952k	111	6	in	in	IN
cord-299731-sis9952k	111	7	adverse	adverse	JJ
cord-299731-sis9952k	111	8	cardiac	cardiac	JJ
cord-299731-sis9952k	111	9	remodeling	remodeling	NN
cord-299731-sis9952k	111	10	,	,	,
cord-299731-sis9952k	111	11	while	while	IN
cord-299731-sis9952k	111	12	long	long	JJ
cord-299731-sis9952k	111	13	-	-	HYPH
cord-299731-sis9952k	111	14	term	term	NN
cord-299731-sis9952k	111	15	supplementation	supplementation	NN
cord-299731-sis9952k	111	16	increases	increase	VBZ
cord-299731-sis9952k	111	17	nucleocytoplasmic	nucleocytoplasmic	NNP
cord-299731-sis9952k	111	18	protein	protein	NN
cord-299731-sis9952k	111	19	acetylation	acetylation	NN
cord-299731-sis9952k	111	20	by	by	IN
cord-299731-sis9952k	111	21	stimulating	stimulate	VBG
cord-299731-sis9952k	111	22	citrate	citrate	NN
cord-299731-sis9952k	111	23	and	and	CC
cord-299731-sis9952k	111	24	acetyl	acetyl	NN
cord-299731-sis9952k	111	25	-	-	HYPH
cord-299731-sis9952k	111	26	CoA	coa	NN
cord-299731-sis9952k	111	27	metabolism	metabolism	NN
cord-299731-sis9952k	111	28	and	and	CC
cord-299731-sis9952k	111	29	antioxidant	antioxidant	JJ
cord-299731-sis9952k	111	30	gene	gene	NN
cord-299731-sis9952k	111	31	expression	expression	NN
cord-299731-sis9952k	111	32	[	[	-LRB-
cord-299731-sis9952k	111	33	66	66	CD
cord-299731-sis9952k	111	34	]	]	-RRB-
cord-299731-sis9952k	111	35	.	.	.
cord-299731-sis9952k	112	1	By	by	IN
cord-299731-sis9952k	112	2	improving	improve	VBG
cord-299731-sis9952k	112	3	NAD	NAD	NNP
cord-299731-sis9952k	112	4	+	+	CC
cord-299731-sis9952k	112	5	homeostasis	homeostasis	NN
cord-299731-sis9952k	112	6	and	and	CC
cord-299731-sis9952k	112	7	activating	activate	VBG
cord-299731-sis9952k	112	8	NMRK2	NMRK2	NNS
cord-299731-sis9952k	112	9	,	,	,
cord-299731-sis9952k	112	10	NR	NR	NNP
cord-299731-sis9952k	112	11	can	can	MD
cord-299731-sis9952k	112	12	further	further	RB
cord-299731-sis9952k	112	13	prevent	prevent	VB
cord-299731-sis9952k	112	14	the	the	DT
cord-299731-sis9952k	112	15	deterioration	deterioration	NN
cord-299731-sis9952k	112	16	of	of	IN
cord-299731-sis9952k	112	17	cardiac	cardiac	JJ
cord-299731-sis9952k	112	18	function	function	NN
cord-299731-sis9952k	112	19	and	and	CC
cord-299731-sis9952k	112	20	adverse	adverse	JJ
cord-299731-sis9952k	112	21	remodeling	remodeling	NN
cord-299731-sis9952k	112	22	,	,	,
cord-299731-sis9952k	112	23	which	which	WDT
cord-299731-sis9952k	112	24	are	be	VBP
cord-299731-sis9952k	112	25	both	both	DT
cord-299731-sis9952k	112	26	early	early	JJ
cord-299731-sis9952k	112	27	and	and	CC
cord-299731-sis9952k	112	28	persistent	persistent	JJ
cord-299731-sis9952k	112	29	events	event	NNS
cord-299731-sis9952k	112	30	in	in	IN
cord-299731-sis9952k	112	31	a	a	DT
cord-299731-sis9952k	112	32	mouse	mouse	NN
cord-299731-sis9952k	112	33	model	model	NN
cord-299731-sis9952k	112	34	of	of	IN
cord-299731-sis9952k	112	35	DCM	DCM	NNP
cord-299731-sis9952k	112	36	leading	lead	VBG
cord-299731-sis9952k	112	37	to	to	IN
cord-299731-sis9952k	112	38	HF	HF	NNP
cord-299731-sis9952k	112	39	.	.	.
cord-299731-sis9952k	113	1	In	in	IN
cord-299731-sis9952k	113	2	several	several	JJ
cord-299731-sis9952k	113	3	models	model	NNS
cord-299731-sis9952k	113	4	of	of	IN
cord-299731-sis9952k	113	5	cardiac	cardiac	JJ
cord-299731-sis9952k	113	6	injuries	injury	NNS
cord-299731-sis9952k	113	7	,	,	,
cord-299731-sis9952k	113	8	the	the	DT
cord-299731-sis9952k	113	9	NAMPT	NAMPT	NNP
cord-299731-sis9952k	113	10	enzyme	enzyme	NN
cord-299731-sis9952k	113	11	is	be	VBZ
cord-299731-sis9952k	113	12	repressed	repress	VBN
cord-299731-sis9952k	113	13	[	[	-LRB-
cord-299731-sis9952k	113	14	62	62	CD
cord-299731-sis9952k	113	15	]	]	-RRB-
cord-299731-sis9952k	113	16	,	,	,
cord-299731-sis9952k	113	17	while	while	IN
cord-299731-sis9952k	113	18	Nmrk2	nmrk2	JJ
cord-299731-sis9952k	113	19	expression	expression	NN
cord-299731-sis9952k	113	20	is	be	VBZ
cord-299731-sis9952k	113	21	robustly	robustly	RB
cord-299731-sis9952k	113	22	upregulated	upregulate	VBN
cord-299731-sis9952k	113	23	[	[	-LRB-
cord-299731-sis9952k	113	24	66	66	CD
cord-299731-sis9952k	113	25	]	]	-RRB-
cord-299731-sis9952k	113	26	.	.	.
cord-299731-sis9952k	114	1	A	a	DT
cord-299731-sis9952k	114	2	similar	similar	JJ
cord-299731-sis9952k	114	3	shift	shift	NN
cord-299731-sis9952k	114	4	was	be	VBD
cord-299731-sis9952k	114	5	observed	observe	VBN
cord-299731-sis9952k	114	6	in	in	IN
cord-299731-sis9952k	114	7	human	human	JJ
cord-299731-sis9952k	114	8	failing	fail	VBG
cord-299731-sis9952k	114	9	heart	heart	NN
cord-299731-sis9952k	114	10	in	in	IN
cord-299731-sis9952k	114	11	models	model	NNS
cord-299731-sis9952k	114	12	of	of	IN
cord-299731-sis9952k	114	13	cardiomyopathy	cardiomyopathy	NN
cord-299731-sis9952k	114	14	[	[	-LRB-
cord-299731-sis9952k	114	15	66	66	CD
cord-299731-sis9952k	114	16	]	]	-RRB-
cord-299731-sis9952k	114	17	.	.	.
cord-299731-sis9952k	115	1	Hence	hence	RB
cord-299731-sis9952k	115	2	,	,	,
cord-299731-sis9952k	115	3	it	-PRON-	PRP
cord-299731-sis9952k	115	4	was	be	VBD
cord-299731-sis9952k	115	5	proposed	propose	VBN
cord-299731-sis9952k	115	6	that	that	IN
cord-299731-sis9952k	115	7	the	the	DT
cord-299731-sis9952k	115	8	activation	activation	NN
cord-299731-sis9952k	115	9	of	of	IN
cord-299731-sis9952k	115	10	the	the	DT
cord-299731-sis9952k	115	11	NMRK2	NMRK2	NNP
cord-299731-sis9952k	115	12	pathway	pathway	NN
cord-299731-sis9952k	115	13	represents	represent	VBZ
cord-299731-sis9952k	115	14	a	a	DT
cord-299731-sis9952k	115	15	common	common	JJ
cord-299731-sis9952k	115	16	adaptive	adaptive	JJ
cord-299731-sis9952k	115	17	mechanism	mechanism	NN
cord-299731-sis9952k	115	18	in	in	IN
cord-299731-sis9952k	115	19	the	the	DT
cord-299731-sis9952k	115	20	failing	fail	VBG
cord-299731-sis9952k	115	21	heart	heart	NN
cord-299731-sis9952k	115	22	,	,	,
cord-299731-sis9952k	115	23	while	while	IN
cord-299731-sis9952k	115	24	the	the	DT
cord-299731-sis9952k	115	25	Nmrk2	nmrk2	JJ
cord-299731-sis9952k	115	26	gene	gene	NN
cord-299731-sis9952k	115	27	can	can	MD
cord-299731-sis9952k	115	28	be	be	VB
cord-299731-sis9952k	115	29	activated	activate	VBN
cord-299731-sis9952k	115	30	in	in	IN
cord-299731-sis9952k	115	31	response	response	NN
cord-299731-sis9952k	115	32	to	to	IN
cord-299731-sis9952k	115	33	NAMPT	NAMPT	NNP
cord-299731-sis9952k	115	34	inhibition	inhibition	NN
cord-299731-sis9952k	115	35	.	.	.
cord-299731-sis9952k	116	1	Furthermore	furthermore	RB
cord-299731-sis9952k	116	2	,	,	,
cord-299731-sis9952k	116	3	the	the	DT
cord-299731-sis9952k	116	4	shift	shift	NN
cord-299731-sis9952k	116	5	from	from	IN
cord-299731-sis9952k	116	6	NAMPT	NAMPT	NNP
cord-299731-sis9952k	116	7	to	to	IN
cord-299731-sis9952k	116	8	NMRK2	NMRK2	NNS
cord-299731-sis9952k	116	9	for	for	IN
cord-299731-sis9952k	116	10	NAD	NAD	NNP
cord-299731-sis9952k	116	11	+	+	CC
cord-299731-sis9952k	116	12	synthesis	synthesis	NN
cord-299731-sis9952k	116	13	is	be	VBZ
cord-299731-sis9952k	116	14	an	an	DT
cord-299731-sis9952k	116	15	energy	energy	NN
cord-299731-sis9952k	116	16	-	-	HYPH
cord-299731-sis9952k	116	17	sparing	spare	VBG
cord-299731-sis9952k	116	18	mechanism	mechanism	NN
cord-299731-sis9952k	116	19	that	that	WDT
cord-299731-sis9952k	116	20	may	may	MD
cord-299731-sis9952k	116	21	be	be	VB
cord-299731-sis9952k	116	22	favored	favor	VBN
cord-299731-sis9952k	116	23	,	,	,
cord-299731-sis9952k	116	24	since	since	IN
cord-299731-sis9952k	116	25	NMN	NMN	NNP
cord-299731-sis9952k	116	26	synthesis	synthesis	NN
cord-299731-sis9952k	116	27	from	from	IN
cord-299731-sis9952k	116	28	NR	NR	NNP
cord-299731-sis9952k	116	29	by	by	IN
cord-299731-sis9952k	116	30	NMRK	NMRK	NNP
cord-299731-sis9952k	116	31	enzymes	enzyme	NNS
cord-299731-sis9952k	116	32	requires	require	VBZ
cord-299731-sis9952k	116	33	a	a	DT
cord-299731-sis9952k	116	34	single	single	JJ
cord-299731-sis9952k	116	35	ATP	ATP	NNP
cord-299731-sis9952k	116	36	,	,	,
cord-299731-sis9952k	116	37	while	while	IN
cord-299731-sis9952k	116	38	synthesis	synthesis	NN
cord-299731-sis9952k	116	39	from	from	IN
cord-299731-sis9952k	116	40	NAM	NAM	NNP
cord-299731-sis9952k	116	41	by	by	IN
cord-299731-sis9952k	116	42	NAMPT	NAMPT	NNP
cord-299731-sis9952k	116	43	requires	require	VBZ
cord-299731-sis9952k	116	44	more	more	JJR
cord-299731-sis9952k	116	45	than	than	IN
cord-299731-sis9952k	116	46	three	three	CD
cord-299731-sis9952k	116	47	ATP	ATP	NNP
cord-299731-sis9952k	116	48	equivalents	equivalent	NNS
cord-299731-sis9952k	116	49	(	(	-LRB-
cord-299731-sis9952k	116	50	Figure	figure	NN
cord-299731-sis9952k	116	51	2	2	CD
cord-299731-sis9952k	116	52	)	)	-RRB-
cord-299731-sis9952k	116	53	.	.	.
cord-299731-sis9952k	117	1	Although	although	IN
cord-299731-sis9952k	117	2	the	the	DT
cord-299731-sis9952k	117	3	NMRK2	NMRK2	NNP
cord-299731-sis9952k	117	4	pathway	pathway	NN
cord-299731-sis9952k	117	5	is	be	VBZ
cord-299731-sis9952k	117	6	activated	activate	VBN
cord-299731-sis9952k	117	7	in	in	IN
cord-299731-sis9952k	117	8	the	the	DT
cord-299731-sis9952k	117	9	HF	HF	NNP
cord-299731-sis9952k	117	10	mice	mouse	NNS
cord-299731-sis9952k	117	11	,	,	,
cord-299731-sis9952k	117	12	the	the	DT
cord-299731-sis9952k	117	13	myocardial	myocardial	JJ
cord-299731-sis9952k	117	14	NAD	NAD	NNP
cord-299731-sis9952k	117	15	+	+	CC
cord-299731-sis9952k	117	16	level	level	NN
cord-299731-sis9952k	117	17	is	be	VBZ
cord-299731-sis9952k	117	18	depressed	depressed	JJ
cord-299731-sis9952k	117	19	,	,	,
cord-299731-sis9952k	117	20	which	which	WDT
cord-299731-sis9952k	117	21	suggests	suggest	VBZ
cord-299731-sis9952k	117	22	that	that	IN
cord-299731-sis9952k	117	23	circulating	circulate	VBG
cord-299731-sis9952k	117	24	and	and	CC
cord-299731-sis9952k	117	25	tissue	tissue	NN
cord-299731-sis9952k	117	26	levels	level	NNS
cord-299731-sis9952k	117	27	of	of	IN
cord-299731-sis9952k	117	28	NAD	NAD	NNP
cord-299731-sis9952k	117	29	+	+	CC
cord-299731-sis9952k	117	30	precursors	precursor	NNS
cord-299731-sis9952k	117	31	are	be	VBP
cord-299731-sis9952k	117	32	insufficient	insufficient	JJ
cord-299731-sis9952k	117	33	to	to	TO
cord-299731-sis9952k	117	34	sustain	sustain	VB
cord-299731-sis9952k	117	35	cardiac	cardiac	JJ
cord-299731-sis9952k	117	36	NAD	NAD	NNP
cord-299731-sis9952k	117	37	+	+	CC
cord-299731-sis9952k	118	1	synthesis	synthesis	NN
cord-299731-sis9952k	118	2	on	on	IN
cord-299731-sis9952k	118	3	a	a	DT
cord-299731-sis9952k	118	4	regular	regular	JJ
cord-299731-sis9952k	118	5	rodent	rodent	NN
cord-299731-sis9952k	118	6	diet	diet	NN
cord-299731-sis9952k	118	7	.	.	.
cord-299731-sis9952k	119	1	This	this	DT
cord-299731-sis9952k	119	2	supports	support	VBZ
cord-299731-sis9952k	119	3	the	the	DT
cord-299731-sis9952k	119	4	interest	interest	NN
cord-299731-sis9952k	119	5	in	in	IN
cord-299731-sis9952k	119	6	NR	NR	NNP
cord-299731-sis9952k	119	7	supplementation	supplementation	NN
cord-299731-sis9952k	119	8	to	to	TO
cord-299731-sis9952k	119	9	improve	improve	VB
cord-299731-sis9952k	119	10	this	this	DT
cord-299731-sis9952k	119	11	condition	condition	NN
cord-299731-sis9952k	119	12	.	.	.
cord-299731-sis9952k	120	1	Moreover	moreover	RB
cord-299731-sis9952k	120	2	,	,	,
cord-299731-sis9952k	120	3	a	a	DT
cord-299731-sis9952k	120	4	strong	strong	JJ
cord-299731-sis9952k	120	5	beneficial	beneficial	JJ
cord-299731-sis9952k	120	6	effect	effect	NN
cord-299731-sis9952k	120	7	of	of	IN
cord-299731-sis9952k	120	8	NR	NR	NNP
cord-299731-sis9952k	120	9	was	be	VBD
cord-299731-sis9952k	120	10	discovered	discover	VBN
cord-299731-sis9952k	120	11	in	in	IN
cord-299731-sis9952k	120	12	mouse	mouse	NN
cord-299731-sis9952k	120	13	models	model	NNS
cord-299731-sis9952k	120	14	of	of	IN
cord-299731-sis9952k	120	15	HF	HF	NNP
cord-299731-sis9952k	120	16	with	with	IN
cord-299731-sis9952k	120	17	the	the	DT
cord-299731-sis9952k	120	18	preservation	preservation	NN
cord-299731-sis9952k	120	19	of	of	IN
cord-299731-sis9952k	120	20	cardiac	cardiac	JJ
cord-299731-sis9952k	120	21	function	function	NN
cord-299731-sis9952k	120	22	and	and	CC
cord-299731-sis9952k	120	23	a	a	DT
cord-299731-sis9952k	120	24	limitation	limitation	NN
cord-299731-sis9952k	120	25	of	of	IN
cord-299731-sis9952k	120	26	cardiac	cardiac	JJ
cord-299731-sis9952k	120	27	remodeling	remodeling	NN
cord-299731-sis9952k	120	28	,	,	,
cord-299731-sis9952k	120	29	that	that	WDT
cord-299731-sis9952k	120	30	was	be	VBD
cord-299731-sis9952k	120	31	associated	associate	VBN
cord-299731-sis9952k	120	32	with	with	IN
cord-299731-sis9952k	120	33	maintained	maintain	VBN
cord-299731-sis9952k	120	34	NAD	NAD	NNP
cord-299731-sis9952k	120	35	+	+	CC
cord-299731-sis9952k	120	36	levels	level	NNS
cord-299731-sis9952k	120	37	in	in	IN
cord-299731-sis9952k	120	38	the	the	DT
cord-299731-sis9952k	120	39	heart	heart	NN
cord-299731-sis9952k	120	40	.	.	.
cord-299731-sis9952k	121	1	This	this	DT
cord-299731-sis9952k	121	2	further	further	RB
cord-299731-sis9952k	121	3	suggests	suggest	VBZ
cord-299731-sis9952k	121	4	that	that	IN
cord-299731-sis9952k	121	5	oral	oral	JJ
cord-299731-sis9952k	121	6	NR	NR	NNP
cord-299731-sis9952k	121	7	supplementation	supplementation	NN
cord-299731-sis9952k	121	8	is	be	VBZ
cord-299731-sis9952k	121	9	a	a	DT
cord-299731-sis9952k	121	10	powerful	powerful	JJ
cord-299731-sis9952k	121	11	approach	approach	NN
cord-299731-sis9952k	121	12	to	to	TO
cord-299731-sis9952k	121	13	preserve	preserve	VB
cord-299731-sis9952k	121	14	cardiac	cardiac	JJ
cord-299731-sis9952k	121	15	function	function	NN
cord-299731-sis9952k	121	16	and	and	CC
cord-299731-sis9952k	121	17	limit	limit	VB
cord-299731-sis9952k	121	18	remodeling	remodeling	NN
cord-299731-sis9952k	121	19	in	in	IN
cord-299731-sis9952k	121	20	DCM	DCM	NNP
cord-299731-sis9952k	121	21	.	.	.
cord-299731-sis9952k	122	1	NAD	NAD	NNP
cord-299731-sis9952k	122	2	+	+	CC
cord-299731-sis9952k	122	3	precursor	precursor	NN
cord-299731-sis9952k	122	4	supplementation	supplementation	NN
cord-299731-sis9952k	122	5	also	also	RB
cord-299731-sis9952k	122	6	has	have	VBZ
cord-299731-sis9952k	122	7	the	the	DT
cord-299731-sis9952k	122	8	potential	potential	NN
cord-299731-sis9952k	122	9	to	to	TO
cord-299731-sis9952k	122	10	protect	protect	VB
cord-299731-sis9952k	122	11	against	against	IN
cord-299731-sis9952k	122	12	adverse	adverse	JJ
cord-299731-sis9952k	122	13	cardiac	cardiac	JJ
cord-299731-sis9952k	122	14	remodeling	remodeling	NN
cord-299731-sis9952k	122	15	by	by	IN
cord-299731-sis9952k	122	16	additional	additional	JJ
cord-299731-sis9952k	122	17	mechanisms	mechanism	NNS
cord-299731-sis9952k	122	18	of	of	IN
cord-299731-sis9952k	122	19	activating	activate	VBG
cord-299731-sis9952k	122	20	SIRTs	sirt	NNS
cord-299731-sis9952k	122	21	(	(	-LRB-
cord-299731-sis9952k	122	22	Table	Table	NNP
cord-299731-sis9952k	122	23	2	2	CD
cord-299731-sis9952k	122	24	)	)	-RRB-
cord-299731-sis9952k	122	25	and	and	CC
cord-299731-sis9952k	122	26	maintaining	maintain	VBG
cord-299731-sis9952k	123	1	Ca	ca	NN
cord-299731-sis9952k	123	2	2	2	CD
cord-299731-sis9952k	123	3	+	+	CC
cord-299731-sis9952k	123	4	homeostasis	homeostasis	NN
cord-299731-sis9952k	123	5	[	[	-LRB-
cord-299731-sis9952k	123	6	67	67	CD
cord-299731-sis9952k	123	7	]	]	-RRB-
cord-299731-sis9952k	123	8	.	.	.
cord-299731-sis9952k	124	1	Namely	namely	RB
cord-299731-sis9952k	124	2	,	,	,
cord-299731-sis9952k	124	3	in	in	IN
cord-299731-sis9952k	124	4	vivo	vivo	NN
cord-299731-sis9952k	124	5	activation	activation	NN
cord-299731-sis9952k	124	6	of	of	IN
cord-299731-sis9952k	124	7	SIRT1	sirt1	NN
cord-299731-sis9952k	124	8	protects	protect	VBZ
cord-299731-sis9952k	124	9	against	against	IN
cord-299731-sis9952k	124	10	cardiac	cardiac	JJ
cord-299731-sis9952k	124	11	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	124	12	,	,	,
cord-299731-sis9952k	124	13	metabolic	metabolic	JJ
cord-299731-sis9952k	124	14	dysregulation	dysregulation	NN
cord-299731-sis9952k	124	15	,	,	,
cord-299731-sis9952k	124	16	and	and	CC
cord-299731-sis9952k	124	17	cardiac	cardiac	JJ
cord-299731-sis9952k	124	18	inflammation	inflammation	NN
cord-299731-sis9952k	124	19	in	in	IN
cord-299731-sis9952k	124	20	a	a	DT
cord-299731-sis9952k	124	21	mouse	mouse	NN
cord-299731-sis9952k	124	22	model	model	NN
cord-299731-sis9952k	124	23	of	of	IN
cord-299731-sis9952k	124	24	cardiac	cardiac	JJ
cord-299731-sis9952k	124	25	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	124	26	,	,	,
cord-299731-sis9952k	124	27	and	and	CC
cord-299731-sis9952k	124	28	exhibits	exhibit	VBZ
cord-299731-sis9952k	124	29	protective	protective	JJ
cord-299731-sis9952k	124	30	effects	effect	NNS
cord-299731-sis9952k	124	31	in	in	IN
cord-299731-sis9952k	124	32	other	other	JJ
cord-299731-sis9952k	124	33	models	model	NNS
cord-299731-sis9952k	124	34	of	of	IN
cord-299731-sis9952k	124	35	cardiac	cardiac	JJ
cord-299731-sis9952k	124	36	dysfunction	dysfunction	NN
cord-299731-sis9952k	124	37	[	[	-LRB-
cord-299731-sis9952k	124	38	68	68	CD
cord-299731-sis9952k	124	39	]	]	-RRB-
cord-299731-sis9952k	124	40	[	[	-LRB-
cord-299731-sis9952k	124	41	69	69	CD
cord-299731-sis9952k	124	42	]	]	-RRB-
cord-299731-sis9952k	124	43	[	[	-LRB-
cord-299731-sis9952k	124	44	70	70	CD
cord-299731-sis9952k	124	45	]	]	-RRB-
cord-299731-sis9952k	124	46	[	[	-LRB-
cord-299731-sis9952k	124	47	71	71	CD
cord-299731-sis9952k	124	48	]	]	-RRB-
cord-299731-sis9952k	124	49	.	.	.
cord-299731-sis9952k	125	1	In	in	IN
cord-299731-sis9952k	125	2	addition	addition	NN
cord-299731-sis9952k	125	3	,	,	,
cord-299731-sis9952k	125	4	SIRT2	SIRT2	NNP
cord-299731-sis9952k	125	5	and	and	CC
cord-299731-sis9952k	125	6	SIRT6	SIRT6	NNP
cord-299731-sis9952k	125	7	have	have	VBP
cord-299731-sis9952k	125	8	emerged	emerge	VBN
cord-299731-sis9952k	125	9	as	as	IN
cord-299731-sis9952k	125	10	prominent	prominent	JJ
cord-299731-sis9952k	125	11	cardioprotective	cardioprotective	JJ
cord-299731-sis9952k	125	12	SIRTs	sirt	NNS
cord-299731-sis9952k	125	13	[	[	-LRB-
cord-299731-sis9952k	125	14	72	72	CD
cord-299731-sis9952k	125	15	,	,	,
cord-299731-sis9952k	125	16	73	73	CD
cord-299731-sis9952k	125	17	]	]	-RRB-
cord-299731-sis9952k	125	18	,	,	,
cord-299731-sis9952k	125	19	as	as	IN
cord-299731-sis9952k	125	20	deficiency	deficiency	NN
cord-299731-sis9952k	125	21	of	of	IN
cord-299731-sis9952k	125	22	SIRT2	SIRT2	NNP
cord-299731-sis9952k	125	23	intensified	intensify	VBN
cord-299731-sis9952k	125	24	cardiac	cardiac	JJ
cord-299731-sis9952k	125	25	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	125	26	in	in	IN
cord-299731-sis9952k	125	27	aged	aged	JJ
cord-299731-sis9952k	125	28	mice	mouse	NNS
cord-299731-sis9952k	125	29	and	and	CC
cord-299731-sis9952k	125	30	mice	mouse	NNS
cord-299731-sis9952k	125	31	stressed	stress	VBN
cord-299731-sis9952k	125	32	with	with	IN
cord-299731-sis9952k	125	33	angiotensin	angiotensin	NN
cord-299731-sis9952k	125	34	II	II	NNP
cord-299731-sis9952k	125	35	[	[	-LRB-
cord-299731-sis9952k	125	36	73	73	CD
cord-299731-sis9952k	125	37	]	]	-RRB-
cord-299731-sis9952k	125	38	,	,	,
cord-299731-sis9952k	125	39	while	while	IN
cord-299731-sis9952k	125	40	a	a	DT
cord-299731-sis9952k	125	41	loss	loss	NN
cord-299731-sis9952k	125	42	of	of	IN
cord-299731-sis9952k	125	43	SIRT6	sirt6	NN
cord-299731-sis9952k	125	44	in	in	IN
cord-299731-sis9952k	125	45	mice	mouse	NNS
cord-299731-sis9952k	125	46	resulted	result	VBD
cord-299731-sis9952k	125	47	in	in	IN
cord-299731-sis9952k	125	48	the	the	DT
cord-299731-sis9952k	125	49	development	development	NN
cord-299731-sis9952k	125	50	of	of	IN
cord-299731-sis9952k	125	51	cardiac	cardiac	JJ
cord-299731-sis9952k	125	52	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	125	53	and	and	CC
cord-299731-sis9952k	125	54	HF	HF	NNP
cord-299731-sis9952k	125	55	[	[	-LRB-
cord-299731-sis9952k	125	56	74	74	CD
cord-299731-sis9952k	125	57	]	]	-RRB-
cord-299731-sis9952k	125	58	.	.	.
cord-299731-sis9952k	126	1	The	the	DT
cord-299731-sis9952k	126	2	activity	activity	NN
cord-299731-sis9952k	126	3	of	of	IN
cord-299731-sis9952k	126	4	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	126	5	SIRTs	sirt	NNS
cord-299731-sis9952k	126	6	is	be	VBZ
cord-299731-sis9952k	126	7	implicated	implicate	VBN
cord-299731-sis9952k	126	8	in	in	IN
cord-299731-sis9952k	126	9	cardiac	cardiac	JJ
cord-299731-sis9952k	126	10	remodeling	remodeling	NN
cord-299731-sis9952k	126	11	and	and	CC
cord-299731-sis9952k	126	12	the	the	DT
cord-299731-sis9952k	126	13	development	development	NN
cord-299731-sis9952k	126	14	of	of	IN
cord-299731-sis9952k	126	15	HF	HF	NNP
cord-299731-sis9952k	126	16	,	,	,
cord-299731-sis9952k	126	17	including	include	VBG
cord-299731-sis9952k	126	18	SIRT3	SIRT3	NNS
cord-299731-sis9952k	126	19	which	which	WDT
cord-299731-sis9952k	126	20	appears	appear	VBZ
cord-299731-sis9952k	126	21	to	to	TO
cord-299731-sis9952k	126	22	be	be	VB
cord-299731-sis9952k	126	23	required	require	VBN
cord-299731-sis9952k	126	24	for	for	IN
cord-299731-sis9952k	126	25	maintaining	maintain	VBG
cord-299731-sis9952k	126	26	cardiac	cardiac	JJ
cord-299731-sis9952k	126	27	function	function	NN
cord-299731-sis9952k	126	28	[	[	-LRB-
cord-299731-sis9952k	126	29	75	75	CD
cord-299731-sis9952k	126	30	]	]	-RRB-
cord-299731-sis9952k	126	31	.	.	.
cord-299731-sis9952k	127	1	Data	datum	NNS
cord-299731-sis9952k	127	2	further	further	RB
cord-299731-sis9952k	127	3	suggests	suggest	VBZ
cord-299731-sis9952k	127	4	NR	NR	NNP
cord-299731-sis9952k	127	5	as	as	IN
cord-299731-sis9952k	127	6	a	a	DT
cord-299731-sis9952k	127	7	favored	favor	VBN
cord-299731-sis9952k	127	8	NAD	NAD	NNP
cord-299731-sis9952k	127	9	+	+	CC
cord-299731-sis9952k	127	10	precursor	precursor	NN
cord-299731-sis9952k	127	11	in	in	IN
cord-299731-sis9952k	127	12	mitochondria	mitochondrion	NNS
cord-299731-sis9952k	127	13	[	[	-LRB-
cord-299731-sis9952k	127	14	76	76	CD
cord-299731-sis9952k	127	15	]	]	-RRB-
cord-299731-sis9952k	127	16	,	,	,
cord-299731-sis9952k	127	17	while	while	IN
cord-299731-sis9952k	127	18	in	in	IN
cord-299731-sis9952k	127	19	vivo	vivo	NNP
cord-299731-sis9952k	127	20	NR	NR	NNP
cord-299731-sis9952k	127	21	effects	effect	NNS
cord-299731-sis9952k	127	22	have	have	VBP
cord-299731-sis9952k	127	23	been	be	VBN
cord-299731-sis9952k	127	24	interpreted	interpret	VBN
cord-299731-sis9952k	127	25	as	as	RB
cord-299731-sis9952k	127	26	dependent	dependent	JJ
cord-299731-sis9952k	127	27	on	on	IN
cord-299731-sis9952k	127	28	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	127	29	sirtuin	sirtuin	NNP
cord-299731-sis9952k	127	30	activities	activity	NNS
cord-299731-sis9952k	127	31	[	[	-LRB-
cord-299731-sis9952k	127	32	37	37	CD
cord-299731-sis9952k	127	33	,	,	,
cord-299731-sis9952k	127	34	77	77	CD
cord-299731-sis9952k	127	35	]	]	-RRB-
cord-299731-sis9952k	127	36	.	.	.
cord-299731-sis9952k	128	1	However	however	RB
cord-299731-sis9952k	128	2	,	,	,
cord-299731-sis9952k	128	3	the	the	DT
cord-299731-sis9952k	128	4	importance	importance	NN
cord-299731-sis9952k	128	5	of	of	IN
cord-299731-sis9952k	128	6	nucleocytosolic	nucleocytosolic	JJ
cord-299731-sis9952k	128	7	targets	target	NNS
cord-299731-sis9952k	128	8	should	should	MD
cord-299731-sis9952k	128	9	not	not	RB
cord-299731-sis9952k	128	10	be	be	VB
cord-299731-sis9952k	128	11	excluded	exclude	VBN
cord-299731-sis9952k	128	12	[	[	-LRB-
cord-299731-sis9952k	128	13	1	1	CD
cord-299731-sis9952k	128	14	,	,	,
cord-299731-sis9952k	128	15	78	78	CD
cord-299731-sis9952k	128	16	]	]	-RRB-
cord-299731-sis9952k	128	17	.	.	.
cord-299731-sis9952k	129	1	NR	nr	NN
cord-299731-sis9952k	129	2	-	-	HYPH
cord-299731-sis9952k	129	3	induced	induce	VBN
cord-299731-sis9952k	129	4	reduction	reduction	NN
cord-299731-sis9952k	129	5	of	of	IN
cord-299731-sis9952k	129	6	systolic	systolic	JJ
cord-299731-sis9952k	129	7	blood	blood	NN
cord-299731-sis9952k	129	8	pressure	pressure	NN
cord-299731-sis9952k	129	9	(	(	-LRB-
cord-299731-sis9952k	129	10	SBP	SBP	NNP
cord-299731-sis9952k	129	11	)	)	-RRB-
cord-299731-sis9952k	129	12	and	and	CC
cord-299731-sis9952k	129	13	aortic	aortic	JJ
cord-299731-sis9952k	129	14	stiffness	stiffness	NN
cord-299731-sis9952k	129	15	[	[	-LRB-
cord-299731-sis9952k	129	16	39	39	CD
cord-299731-sis9952k	129	17	]	]	-RRB-
cord-299731-sis9952k	129	18	,	,	,
cord-299731-sis9952k	129	19	two	two	CD
cord-299731-sis9952k	129	20	clinically	clinically	RB
cord-299731-sis9952k	129	21	important	important	JJ
cord-299731-sis9952k	129	22	risk	risk	NN
cord-299731-sis9952k	129	23	indicators	indicator	NNS
cord-299731-sis9952k	129	24	of	of	IN
cord-299731-sis9952k	129	25	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	129	26	function	function	NN
cord-299731-sis9952k	129	27	and	and	CC
cord-299731-sis9952k	129	28	health	health	NN
cord-299731-sis9952k	129	29	[	[	-LRB-
cord-299731-sis9952k	129	30	79	79	CD
cord-299731-sis9952k	129	31	,	,	,
cord-299731-sis9952k	129	32	80	80	CD
cord-299731-sis9952k	129	33	]	]	-RRB-
cord-299731-sis9952k	129	34	,	,	,
cord-299731-sis9952k	129	35	may	may	MD
cord-299731-sis9952k	129	36	occur	occur	VB
cord-299731-sis9952k	129	37	due	due	IN
cord-299731-sis9952k	129	38	to	to	IN
cord-299731-sis9952k	129	39	nuclear	nuclear	JJ
cord-299731-sis9952k	129	40	and	and	CC
cord-299731-sis9952k	129	41	cytosolic	cytosolic	JJ
cord-299731-sis9952k	129	42	SIRT1	sirt1	NN
cord-299731-sis9952k	129	43	activation	activation	NN
cord-299731-sis9952k	129	44	(	(	-LRB-
cord-299731-sis9952k	129	45	Table	Table	NNP
cord-299731-sis9952k	129	46	1	1	CD
cord-299731-sis9952k	129	47	)	)	-RRB-
cord-299731-sis9952k	129	48	.	.	.
cord-299731-sis9952k	130	1	Namely	namely	RB
cord-299731-sis9952k	130	2	,	,	,
cord-299731-sis9952k	130	3	NAD	NAD	NNP
cord-299731-sis9952k	130	4	+	+	CC
cord-299731-sis9952k	130	5	is	be	VBZ
cord-299731-sis9952k	130	6	an	an	DT
cord-299731-sis9952k	130	7	obligate	obligate	NN
cord-299731-sis9952k	130	8	substrate	substrate	NN
cord-299731-sis9952k	130	9	for	for	IN
cord-299731-sis9952k	130	10	the	the	DT
cord-299731-sis9952k	130	11	deacetylase	deacetylase	NN
cord-299731-sis9952k	130	12	SIRT1	sirt1	NN
cord-299731-sis9952k	130	13	,	,	,
cord-299731-sis9952k	130	14	which	which	WDT
cord-299731-sis9952k	130	15	has	have	VBZ
cord-299731-sis9952k	130	16	been	be	VBN
cord-299731-sis9952k	130	17	implicated	implicate	VBN
cord-299731-sis9952k	130	18	in	in	IN
cord-299731-sis9952k	130	19	the	the	DT
cord-299731-sis9952k	130	20	maintenance	maintenance	NN
cord-299731-sis9952k	130	21	of	of	IN
cord-299731-sis9952k	130	22	healthy	healthy	JJ
cord-299731-sis9952k	130	23	vascular	vascular	JJ
cord-299731-sis9952k	130	24	function	function	NN
cord-299731-sis9952k	130	25	[	[	-LRB-
cord-299731-sis9952k	130	26	81	81	CD
cord-299731-sis9952k	130	27	]	]	-RRB-
cord-299731-sis9952k	130	28	[	[	-LRB-
cord-299731-sis9952k	130	29	82	82	CD
cord-299731-sis9952k	130	30	]	]	-RRB-
cord-299731-sis9952k	130	31	[	[	-LRB-
cord-299731-sis9952k	130	32	83	83	CD
cord-299731-sis9952k	130	33	]	]	-RRB-
cord-299731-sis9952k	130	34	.	.	.
cord-299731-sis9952k	131	1	Although	although	IN
cord-299731-sis9952k	131	2	NAD	NAD	NNP
cord-299731-sis9952k	131	3	+	+	CC
cord-299731-sis9952k	131	4	involvement	involvement	NN
cord-299731-sis9952k	131	5	in	in	IN
cord-299731-sis9952k	131	6	numerous	numerous	JJ
cord-299731-sis9952k	131	7	physiological	physiological	JJ
cord-299731-sis9952k	131	8	responses	response	NNS
cord-299731-sis9952k	131	9	is	be	VBZ
cord-299731-sis9952k	131	10	not	not	RB
cord-299731-sis9952k	131	11	yet	yet	RB
cord-299731-sis9952k	131	12	fully	fully	RB
cord-299731-sis9952k	131	13	understood	understand	VBN
cord-299731-sis9952k	131	14	,	,	,
cord-299731-sis9952k	131	15	documented	document	VBD
cord-299731-sis9952k	131	16	health	health	NN
cord-299731-sis9952k	131	17	benefits	benefit	NNS
cord-299731-sis9952k	131	18	in	in	IN
cord-299731-sis9952k	131	19	mice	mouse	NNS
cord-299731-sis9952k	131	20	models	model	NNS
cord-299731-sis9952k	131	21	validate	validate	VBP
cord-299731-sis9952k	131	22	the	the	DT
cord-299731-sis9952k	131	23	increasing	increase	VBG
cord-299731-sis9952k	131	24	interest	interest	NN
cord-299731-sis9952k	131	25	in	in	IN
cord-299731-sis9952k	131	26	the	the	DT
cord-299731-sis9952k	131	27	translation	translation	NN
cord-299731-sis9952k	131	28	of	of	IN
cord-299731-sis9952k	131	29	NR	NR	NNP
cord-299731-sis9952k	131	30	to	to	IN
cord-299731-sis9952k	131	31	therapy	therapy	NN
cord-299731-sis9952k	131	32	for	for	IN
cord-299731-sis9952k	131	33	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	131	34	diseases	disease	NNS
cord-299731-sis9952k	131	35	,	,	,
cord-299731-sis9952k	131	36	especially	especially	RB
cord-299731-sis9952k	131	37	in	in	IN
cord-299731-sis9952k	131	38	HF	HF	NNP
cord-299731-sis9952k	131	39	and	and	CC
cord-299731-sis9952k	131	40	cardiac	cardiac	JJ
cord-299731-sis9952k	131	41	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	131	42	.	.	.
cord-299731-sis9952k	132	1	Table	table	NN
cord-299731-sis9952k	132	2	2	2	CD
cord-299731-sis9952k	132	3	.	.	.
cord-299731-sis9952k	133	1	The	the	DT
cord-299731-sis9952k	133	2	roles	role	NNS
cord-299731-sis9952k	133	3	of	of	IN
cord-299731-sis9952k	133	4	sirtuins	sirtuin	NNS
cord-299731-sis9952k	133	5	in	in	IN
cord-299731-sis9952k	133	6	heart	heart	NN
cord-299731-sis9952k	133	7	failure	failure	NN
cord-299731-sis9952k	133	8	development	development	NN
cord-299731-sis9952k	133	9	acquired	acquire	VBN
cord-299731-sis9952k	133	10	from	from	IN
cord-299731-sis9952k	133	11	experiments	experiment	NNS
cord-299731-sis9952k	133	12	on	on	IN
cord-299731-sis9952k	133	13	knock	knock	NN
cord-299731-sis9952k	133	14	-	-	HYPH
cord-299731-sis9952k	133	15	out	out	NN
cord-299731-sis9952k	133	16	and	and	CC
cord-299731-sis9952k	133	17	transgenic	transgenic	JJ
cord-299731-sis9952k	133	18	mice	mouse	NNS
cord-299731-sis9952k	133	19	(	(	-LRB-
cord-299731-sis9952k	133	20	adapted	adapt	VBN
cord-299731-sis9952k	133	21	from	from	IN
cord-299731-sis9952k	133	22	Pillai	Pillai	NNP
cord-299731-sis9952k	133	23	et	et	NNP
cord-299731-sis9952k	133	24	al	al	NNP
cord-299731-sis9952k	133	25	.	.	NNP
cord-299731-sis9952k	133	26	,	,	,
cord-299731-sis9952k	133	27	[	[	-LRB-
cord-299731-sis9952k	133	28	84	84	CD
cord-299731-sis9952k	133	29	]	]	-RRB-
cord-299731-sis9952k	133	30	)	)	-RRB-
cord-299731-sis9952k	133	31	.	.	.
cord-299731-sis9952k	134	1	Heart	heart	NN
cord-299731-sis9952k	134	2	cell	cell	NN
cord-299731-sis9952k	134	3	growth	growth	NN
cord-299731-sis9952k	134	4	and	and	CC
cord-299731-sis9952k	134	5	development	development	NN
cord-299731-sis9952k	134	6	,	,	,
cord-299731-sis9952k	134	7	mediation	mediation	NN
cord-299731-sis9952k	134	8	of	of	IN
cord-299731-sis9952k	134	9	cardiac	cardiac	JJ
cord-299731-sis9952k	134	10	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	134	11	,	,	,
cord-299731-sis9952k	134	12	protection	protection	NN
cord-299731-sis9952k	134	13	from	from	IN
cord-299731-sis9952k	134	14	ischemic	ischemic	JJ
cord-299731-sis9952k	134	15	injury	injury	NN
cord-299731-sis9952k	134	16	;	;	,
cord-299731-sis9952k	134	17	partial	partial	JJ
cord-299731-sis9952k	134	18	deficiency	deficiency	NN
cord-299731-sis9952k	134	19	protects	protect	VBZ
cord-299731-sis9952k	134	20	from	from	IN
cord-299731-sis9952k	134	21	pressure	pressure	NN
cord-299731-sis9952k	134	22	overload	overload	NN
cord-299731-sis9952k	134	23	-	-	HYPH
cord-299731-sis9952k	134	24	induced	induce	VBN
cord-299731-sis9952k	134	25	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	134	26	and	and	CC
cord-299731-sis9952k	134	27	failure	failure	NN
cord-299731-sis9952k	134	28	SIRT2	SIRT2	NNP
cord-299731-sis9952k	135	1	Mediating	mediate	VBG
cord-299731-sis9952k	135	2	ischemic	ischemic	JJ
cord-299731-sis9952k	135	3	injury	injury	NN
cord-299731-sis9952k	135	4	due	due	IN
cord-299731-sis9952k	135	5	to	to	IN
cord-299731-sis9952k	135	6	attenuated	attenuated	JJ
cord-299731-sis9952k	135	7	programmed	program	VBN
cord-299731-sis9952k	135	8	apoptosis	apoptosis	NN
cord-299731-sis9952k	135	9	SIRT3	SIRT3	NNP
cord-299731-sis9952k	135	10	Protection	Protection	NNP
cord-299731-sis9952k	135	11	from	from	IN
cord-299731-sis9952k	135	12	age	age	NN
cord-299731-sis9952k	135	13	-	-	HYPH
cord-299731-sis9952k	135	14	induced	induce	VBN
cord-299731-sis9952k	135	15	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	135	16	,	,	,
cord-299731-sis9952k	135	17	fibrosis	fibrosis	NN
cord-299731-sis9952k	135	18	and	and	CC
cord-299731-sis9952k	135	19	contractile	contractile	JJ
cord-299731-sis9952k	135	20	dysfunction	dysfunction	NN
cord-299731-sis9952k	135	21	,	,	,
cord-299731-sis9952k	135	22	prevents	prevent	VBZ
cord-299731-sis9952k	135	23	susceptibility	susceptibility	NN
cord-299731-sis9952k	135	24	to	to	IN
cord-299731-sis9952k	135	25	cardiac	cardiac	JJ
cord-299731-sis9952k	135	26	hypertrophic	hypertrophic	JJ
cord-299731-sis9952k	135	27	stimuli	stimulus	NNS
cord-299731-sis9952k	136	1	SIRT6	SIRT6	NNP
cord-299731-sis9952k	137	1	Protection	protection	NN
cord-299731-sis9952k	137	2	from	from	IN
cord-299731-sis9952k	137	3	cardiac	cardiac	JJ
cord-299731-sis9952k	137	4	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	137	5	and	and	CC
cord-299731-sis9952k	137	6	heart	heart	NN
cord-299731-sis9952k	137	7	failure	failure	NN
cord-299731-sis9952k	138	1	SIRT7	sirt7	UH
cord-299731-sis9952k	138	2	Protection	Protection	NNP
cord-299731-sis9952k	138	3	from	from	IN
cord-299731-sis9952k	138	4	spontaneous	spontaneous	JJ
cord-299731-sis9952k	138	5	cardiac	cardiac	JJ
cord-299731-sis9952k	138	6	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	138	7	and	and	CC
cord-299731-sis9952k	138	8	inflammatory	inflammatory	JJ
cord-299731-sis9952k	138	9	cardiomyopathy	cardiomyopathy	NN
cord-299731-sis9952k	139	1	SIRT1	SIRT1	NNP
cord-299731-sis9952k	140	1	Low	low	JJ
cord-299731-sis9952k	140	2	to	to	IN
cord-299731-sis9952k	140	3	moderate	moderate	JJ
cord-299731-sis9952k	140	4	overexpression	overexpression	NN
cord-299731-sis9952k	140	5	attenuates	attenuate	VBZ
cord-299731-sis9952k	140	6	age	age	NN
cord-299731-sis9952k	140	7	-	-	HYPH
cord-299731-sis9952k	140	8	dependent	dependent	JJ
cord-299731-sis9952k	140	9	decline	decline	NN
cord-299731-sis9952k	140	10	in	in	IN
cord-299731-sis9952k	140	11	cardiac	cardiac	JJ
cord-299731-sis9952k	140	12	functions	function	NNS
cord-299731-sis9952k	140	13	in	in	IN
cord-299731-sis9952k	140	14	mice	mouse	NNS
cord-299731-sis9952k	140	15	,	,	,
cord-299731-sis9952k	140	16	while	while	IN
cord-299731-sis9952k	140	17	high	high	JJ
cord-299731-sis9952k	140	18	overexpression	overexpression	NN
cord-299731-sis9952k	140	19	induces	induce	VBZ
cord-299731-sis9952k	140	20	cardiac	cardiac	JJ
cord-299731-sis9952k	140	21	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	140	22	and	and	CC
cord-299731-sis9952k	140	23	heart	heart	NN
cord-299731-sis9952k	140	24	failure	failure	NN
cord-299731-sis9952k	140	25	SIRT3	SIRT3	NNP
cord-299731-sis9952k	141	1	Cardiac	cardiac	JJ
cord-299731-sis9952k	141	2	-	-	HYPH
cord-299731-sis9952k	141	3	specific	specific	JJ
cord-299731-sis9952k	141	4	overexpression	overexpression	NN
cord-299731-sis9952k	141	5	protects	protect	VBZ
cord-299731-sis9952k	141	6	the	the	DT
cord-299731-sis9952k	141	7	heart	heart	NN
cord-299731-sis9952k	141	8	from	from	IN
cord-299731-sis9952k	141	9	hypertrophic	hypertrophic	JJ
cord-299731-sis9952k	141	10	stimuli	stimulus	NNS
cord-299731-sis9952k	141	11	by	by	IN
cord-299731-sis9952k	141	12	preserving	preserve	VBG
cord-299731-sis9952k	141	13	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	141	14	function	function	NN
cord-299731-sis9952k	141	15	SIRT6	SIRT6	NNP
cord-299731-sis9952k	142	1	Cardiac	cardiac	JJ
cord-299731-sis9952k	142	2	-	-	HYPH
cord-299731-sis9952k	142	3	specific	specific	JJ
cord-299731-sis9952k	142	4	overexpression	overexpression	NN
cord-299731-sis9952k	142	5	protects	protect	VBZ
cord-299731-sis9952k	142	6	the	the	DT
cord-299731-sis9952k	142	7	heart	heart	NN
cord-299731-sis9952k	142	8	from	from	IN
cord-299731-sis9952k	142	9	hypertrophic	hypertrophic	JJ
cord-299731-sis9952k	142	10	stimuli	stimulus	NNS
cord-299731-sis9952k	142	11	by	by	IN
cord-299731-sis9952k	142	12	blocking	block	VBG
cord-299731-sis9952k	142	13	activation	activation	NN
cord-299731-sis9952k	142	14	of	of	IN
cord-299731-sis9952k	142	15	Akt	Akt	NNP
cord-299731-sis9952k	142	16	signaling	signal	VBG
cord-299731-sis9952k	142	17	at	at	IN
cord-299731-sis9952k	142	18	the	the	DT
cord-299731-sis9952k	142	19	level	level	NN
cord-299731-sis9952k	142	20	of	of	IN
cord-299731-sis9952k	142	21	chromatin	chromatin	JJ
cord-299731-sis9952k	142	22	Neurodegenerative	Neurodegenerative	NNP
cord-299731-sis9952k	142	23	disorders	disorder	NNS
cord-299731-sis9952k	142	24	are	be	VBP
cord-299731-sis9952k	142	25	associated	associate	VBN
cord-299731-sis9952k	142	26	with	with	IN
cord-299731-sis9952k	142	27	DNA	dna	NN
cord-299731-sis9952k	142	28	damage	damage	NN
cord-299731-sis9952k	142	29	and	and	CC
cord-299731-sis9952k	142	30	oxidative	oxidative	JJ
cord-299731-sis9952k	142	31	stress	stress	NN
cord-299731-sis9952k	142	32	,	,	,
cord-299731-sis9952k	142	33	which	which	WDT
cord-299731-sis9952k	142	34	accumulate	accumulate	VBP
cord-299731-sis9952k	142	35	with	with	IN
cord-299731-sis9952k	142	36	age	age	NN
cord-299731-sis9952k	142	37	[	[	-LRB-
cord-299731-sis9952k	142	38	85	85	CD
cord-299731-sis9952k	142	39	]	]	-RRB-
cord-299731-sis9952k	142	40	leading	lead	VBG
cord-299731-sis9952k	142	41	to	to	IN
cord-299731-sis9952k	142	42	impaired	impaired	JJ
cord-299731-sis9952k	142	43	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	142	44	function	function	NN
cord-299731-sis9952k	142	45	[	[	-LRB-
cord-299731-sis9952k	142	46	86	86	CD
cord-299731-sis9952k	142	47	]	]	-RRB-
cord-299731-sis9952k	142	48	.	.	.
cord-299731-sis9952k	143	1	In	in	IN
cord-299731-sis9952k	143	2	addition	addition	NN
cord-299731-sis9952k	143	3	,	,	,
cord-299731-sis9952k	143	4	NAD	NAD	NNP
cord-299731-sis9952k	143	5	+	+	CC
cord-299731-sis9952k	143	6	depletion	depletion	NN
cord-299731-sis9952k	143	7	was	be	VBD
cord-299731-sis9952k	143	8	observed	observe	VBN
cord-299731-sis9952k	143	9	during	during	IN
cord-299731-sis9952k	143	10	the	the	DT
cord-299731-sis9952k	143	11	aging	age	VBG
cord-299731-sis9952k	143	12	process	process	NN
cord-299731-sis9952k	143	13	in	in	IN
cord-299731-sis9952k	143	14	multiple	multiple	JJ
cord-299731-sis9952k	143	15	animals	animal	NNS
cord-299731-sis9952k	143	16	,	,	,
cord-299731-sis9952k	143	17	including	include	VBG
cord-299731-sis9952k	143	18	humans	human	NNS
cord-299731-sis9952k	143	19	,	,	,
cord-299731-sis9952k	143	20	and	and	CC
cord-299731-sis9952k	143	21	is	be	VBZ
cord-299731-sis9952k	143	22	considered	consider	VBN
cord-299731-sis9952k	143	23	the	the	DT
cord-299731-sis9952k	143	24	major	major	JJ
cord-299731-sis9952k	143	25	risk	risk	NN
cord-299731-sis9952k	143	26	factor	factor	NN
cord-299731-sis9952k	143	27	for	for	IN
cord-299731-sis9952k	143	28	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	143	29	's	's	POS
cord-299731-sis9952k	143	30	disease	disease	NN
cord-299731-sis9952k	143	31	(	(	-LRB-
cord-299731-sis9952k	143	32	AD	ad	NN
cord-299731-sis9952k	143	33	)	)	-RRB-
cord-299731-sis9952k	143	34	[	[	-LRB-
cord-299731-sis9952k	143	35	87	87	CD
cord-299731-sis9952k	143	36	]	]	-RRB-
cord-299731-sis9952k	143	37	.	.	.
cord-299731-sis9952k	144	1	When	when	WRB
cord-299731-sis9952k	144	2	administered	administer	VBN
cord-299731-sis9952k	144	3	in	in	IN
cord-299731-sis9952k	144	4	AD	ad	NN
cord-299731-sis9952k	144	5	mouse	mouse	NN
cord-299731-sis9952k	144	6	models	model	NNS
cord-299731-sis9952k	144	7	,	,	,
cord-299731-sis9952k	144	8	NR	NR	NNP
cord-299731-sis9952k	144	9	displays	display	VBZ
cord-299731-sis9952k	144	10	beneficial	beneficial	JJ
cord-299731-sis9952k	144	11	effects	effect	NNS
cord-299731-sis9952k	144	12	on	on	IN
cord-299731-sis9952k	144	13	both	both	DT
cord-299731-sis9952k	144	14	oxidative	oxidative	JJ
cord-299731-sis9952k	144	15	stress	stress	NN
cord-299731-sis9952k	144	16	and	and	CC
cord-299731-sis9952k	144	17	DNA	dna	NN
cord-299731-sis9952k	144	18	repair	repair	NN
cord-299731-sis9952k	144	19	by	by	IN
cord-299731-sis9952k	144	20	increasing	increase	VBG
cord-299731-sis9952k	144	21	NAD	NAD	NNP
cord-299731-sis9952k	145	1	+	+	CC
cord-299731-sis9952k	145	2	levels	level	NNS
cord-299731-sis9952k	145	3	[	[	-LRB-
cord-299731-sis9952k	145	4	88	88	CD
cord-299731-sis9952k	145	5	]	]	-RRB-
cord-299731-sis9952k	145	6	.	.	.
cord-299731-sis9952k	146	1	Additionally	additionally	RB
cord-299731-sis9952k	146	2	,	,	,
cord-299731-sis9952k	146	3	NR	NR	NNP
cord-299731-sis9952k	146	4	can	can	MD
cord-299731-sis9952k	146	5	improve	improve	VB
cord-299731-sis9952k	146	6	other	other	JJ
cord-299731-sis9952k	146	7	aspects	aspect	NNS
cord-299731-sis9952k	146	8	of	of	IN
cord-299731-sis9952k	146	9	AD	ad	NN
cord-299731-sis9952k	146	10	neuropathology	neuropathology	NN
cord-299731-sis9952k	146	11	including	include	VBG
cord-299731-sis9952k	146	12	pTau	pTau	NNP
cord-299731-sis9952k	146	13	,	,	,
cord-299731-sis9952k	146	14	amyloid	amyloid	NN
cord-299731-sis9952k	146	15	-	-	HYPH
cord-299731-sis9952k	146	16	β	β	NN
cord-299731-sis9952k	146	17	,	,	,
cord-299731-sis9952k	146	18	neurogenesis	neurogenesis	NN
cord-299731-sis9952k	146	19	,	,	,
cord-299731-sis9952k	146	20	neuroinflammation	neuroinflammation	NN
cord-299731-sis9952k	146	21	,	,	,
cord-299731-sis9952k	146	22	hippocampal	hippocampal	JJ
cord-299731-sis9952k	146	23	synaptic	synaptic	JJ
cord-299731-sis9952k	146	24	plasticity	plasticity	NN
cord-299731-sis9952k	146	25	,	,	,
cord-299731-sis9952k	146	26	and	and	CC
cord-299731-sis9952k	146	27	cognition	cognition	NN
cord-299731-sis9952k	146	28	[	[	-LRB-
cord-299731-sis9952k	146	29	89	89	CD
cord-299731-sis9952k	146	30	,	,	,
cord-299731-sis9952k	146	31	90	90	CD
cord-299731-sis9952k	146	32	]	]	-RRB-
cord-299731-sis9952k	146	33	.	.	.
cord-299731-sis9952k	147	1	Specifically	specifically	RB
cord-299731-sis9952k	147	2	,	,	,
cord-299731-sis9952k	147	3	NR	NR	NNP
cord-299731-sis9952k	147	4	treatment	treatment	NN
cord-299731-sis9952k	147	5	reduce	reduce	VBP
cord-299731-sis9952k	147	6	neuroinflammation	neuroinflammation	NN
cord-299731-sis9952k	147	7	and	and	CC
cord-299731-sis9952k	147	8	amyloidogenesis	amyloidogenesis	NN
cord-299731-sis9952k	147	9	in	in	IN
cord-299731-sis9952k	147	10	the	the	DT
cord-299731-sis9952k	147	11	whole	whole	JJ
cord-299731-sis9952k	147	12	brain	brain	NN
cord-299731-sis9952k	147	13	of	of	IN
cord-299731-sis9952k	147	14	high	high	JJ
cord-299731-sis9952k	147	15	-	-	HYPH
cord-299731-sis9952k	147	16	fat	fat	NN
cord-299731-sis9952k	147	17	diet	diet	NN
cord-299731-sis9952k	147	18	(	(	-LRB-
cord-299731-sis9952k	147	19	HFD)-fed	HFD)-fed	NNP
cord-299731-sis9952k	147	20	mice	mouse	NNS
cord-299731-sis9952k	147	21	,	,	,
cord-299731-sis9952k	147	22	by	by	IN
cord-299731-sis9952k	147	23	decreasing	decrease	VBG
cord-299731-sis9952k	147	24	amyloid	amyloid	NN
cord-299731-sis9952k	147	25	-	-	HYPH
cord-299731-sis9952k	147	26	β	β	NN
cord-299731-sis9952k	147	27	levels	level	NNS
cord-299731-sis9952k	147	28	and	and	CC
cord-299731-sis9952k	147	29	several	several	JJ
cord-299731-sis9952k	147	30	inflammatory	inflammatory	JJ
cord-299731-sis9952k	147	31	markers	marker	NNS
cord-299731-sis9952k	147	32	(	(	-LRB-
cord-299731-sis9952k	147	33	NLRP3	nlrp3	XX
cord-299731-sis9952k	147	34	,	,	,
cord-299731-sis9952k	147	35	CASP1	CASP1	NNP
cord-299731-sis9952k	147	36	,	,	,
cord-299731-sis9952k	147	37	IL-1	IL-1	NNP
cord-299731-sis9952k	147	38	,	,	,
cord-299731-sis9952k	147	39	TNF	TNF	NNP
cord-299731-sis9952k	147	40	-	-	HYPH
cord-299731-sis9952k	147	41	α	α	NNP
cord-299731-sis9952k	147	42	,	,	,
cord-299731-sis9952k	147	43	and	and	CC
cord-299731-sis9952k	147	44	IL-6	IL-6	NNP
cord-299731-sis9952k	147	45	)	)	-RRB-
cord-299731-sis9952k	147	46	[	[	-LRB-
cord-299731-sis9952k	147	47	91	91	CD
cord-299731-sis9952k	147	48	]	]	-RRB-
cord-299731-sis9952k	147	49	.	.	.
cord-299731-sis9952k	148	1	Since	since	IN
cord-299731-sis9952k	148	2	brain	brain	NN
cord-299731-sis9952k	148	3	inflammation	inflammation	NN
cord-299731-sis9952k	148	4	is	be	VBZ
cord-299731-sis9952k	148	5	closely	closely	RB
cord-299731-sis9952k	148	6	related	relate	VBN
cord-299731-sis9952k	148	7	to	to	IN
cord-299731-sis9952k	148	8	cognitive	cognitive	JJ
cord-299731-sis9952k	148	9	impairment	impairment	NN
cord-299731-sis9952k	148	10	[	[	-LRB-
cord-299731-sis9952k	148	11	92	92	CD
cord-299731-sis9952k	148	12	]	]	-RRB-
cord-299731-sis9952k	148	13	[	[	-LRB-
cord-299731-sis9952k	148	14	93	93	CD
cord-299731-sis9952k	148	15	]	]	-RRB-
cord-299731-sis9952k	148	16	[	[	-LRB-
cord-299731-sis9952k	148	17	94	94	CD
cord-299731-sis9952k	148	18	]	]	-RRB-
cord-299731-sis9952k	148	19	,	,	.
cord-299731-sis9952k	149	1	cognitive	cognitive	JJ
cord-299731-sis9952k	149	2	function	function	NN
cord-299731-sis9952k	149	3	and	and	CC
cord-299731-sis9952k	149	4	recognition	recognition	NN
cord-299731-sis9952k	149	5	memory	memory	NN
cord-299731-sis9952k	149	6	could	could	MD
cord-299731-sis9952k	149	7	be	be	VB
cord-299731-sis9952k	149	8	attenuated	attenuate	VBN
cord-299731-sis9952k	149	9	by	by	IN
cord-299731-sis9952k	149	10	NR	NR	NNP
cord-299731-sis9952k	149	11	treatment	treatment	NN
cord-299731-sis9952k	149	12	in	in	IN
cord-299731-sis9952k	149	13	only	only	RB
cord-299731-sis9952k	149	14	6	6	CD
cord-299731-sis9952k	149	15	weeks	week	NNS
cord-299731-sis9952k	149	16	[	[	-LRB-
cord-299731-sis9952k	149	17	91	91	CD
cord-299731-sis9952k	149	18	]	]	-RRB-
cord-299731-sis9952k	149	19	.	.	.
cord-299731-sis9952k	150	1	Furthermore	furthermore	RB
cord-299731-sis9952k	150	2	,	,	,
cord-299731-sis9952k	150	3	increased	increase	VBN
cord-299731-sis9952k	150	4	PARylation	parylation	NN
cord-299731-sis9952k	150	5	,	,	,
cord-299731-sis9952k	150	6	another	another	DT
cord-299731-sis9952k	150	7	hallmark	hallmark	NN
cord-299731-sis9952k	150	8	of	of	IN
cord-299731-sis9952k	150	9	AD	ad	NN
cord-299731-sis9952k	150	10	,	,	,
cord-299731-sis9952k	150	11	could	could	MD
cord-299731-sis9952k	150	12	be	be	VB
cord-299731-sis9952k	150	13	decreased	decrease	VBN
cord-299731-sis9952k	150	14	in	in	IN
cord-299731-sis9952k	150	15	AD	ad	NN
cord-299731-sis9952k	150	16	mice	mouse	NNS
cord-299731-sis9952k	150	17	with	with	IN
cord-299731-sis9952k	150	18	NR	NR	NNP
cord-299731-sis9952k	150	19	supplementation	supplementation	NN
cord-299731-sis9952k	150	20	[	[	-LRB-
cord-299731-sis9952k	150	21	90	90	CD
cord-299731-sis9952k	150	22	]	]	-RRB-
cord-299731-sis9952k	150	23	.	.	.
cord-299731-sis9952k	151	1	Increased	increase	VBN
cord-299731-sis9952k	151	2	PARylation	parylation	NN
cord-299731-sis9952k	151	3	has	have	VBZ
cord-299731-sis9952k	151	4	also	also	RB
cord-299731-sis9952k	151	5	been	be	VBN
cord-299731-sis9952k	151	6	detected	detect	VBN
cord-299731-sis9952k	151	7	in	in	IN
cord-299731-sis9952k	151	8	several	several	JJ
cord-299731-sis9952k	151	9	other	other	JJ
cord-299731-sis9952k	151	10	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	151	11	disorders	disorder	NNS
cord-299731-sis9952k	151	12	that	that	WDT
cord-299731-sis9952k	151	13	involve	involve	VBP
cord-299731-sis9952k	151	14	DNA	dna	NN
cord-299731-sis9952k	151	15	repair	repair	NN
cord-299731-sis9952k	151	16	defects	defect	NNS
cord-299731-sis9952k	151	17	,	,	,
cord-299731-sis9952k	151	18	including	include	VBG
cord-299731-sis9952k	151	19	Cockayne	Cockayne	NNP
cord-299731-sis9952k	151	20	syndrome	syndrome	NN
cord-299731-sis9952k	151	21	,	,	,
cord-299731-sis9952k	151	22	xeroderma	xeroderma	NNP
cord-299731-sis9952k	151	23	pigmentosum	pigmentosum	NNP
cord-299731-sis9952k	151	24	and	and	CC
cord-299731-sis9952k	151	25	ataxia	ataxia	NN
cord-299731-sis9952k	151	26	-	-	HYPH
cord-299731-sis9952k	151	27	telangiectasia	telangiectasia	NN
cord-299731-sis9952k	151	28	.	.	.
cord-299731-sis9952k	152	1	Nevertheless	nevertheless	RB
cord-299731-sis9952k	152	2	,	,	,
cord-299731-sis9952k	152	3	PARP	PARP	NNP
cord-299731-sis9952k	152	4	-	-	HYPH
cord-299731-sis9952k	152	5	mediated	mediate	VBN
cord-299731-sis9952k	152	6	NAD	NAD	NNP
cord-299731-sis9952k	152	7	+	+	CC
cord-299731-sis9952k	152	8	depletion	depletion	NN
cord-299731-sis9952k	152	9	was	be	VBD
cord-299731-sis9952k	152	10	recently	recently	RB
cord-299731-sis9952k	152	11	confirmed	confirm	VBN
cord-299731-sis9952k	152	12	to	to	TO
cord-299731-sis9952k	152	13	play	play	VB
cord-299731-sis9952k	152	14	a	a	DT
cord-299731-sis9952k	152	15	major	major	JJ
cord-299731-sis9952k	152	16	role	role	NN
cord-299731-sis9952k	152	17	in	in	IN
cord-299731-sis9952k	152	18	the	the	DT
cord-299731-sis9952k	152	19	pathogenesis	pathogenesis	NN
cord-299731-sis9952k	152	20	of	of	IN
cord-299731-sis9952k	152	21	these	these	DT
cord-299731-sis9952k	152	22	disorders	disorder	NNS
cord-299731-sis9952k	152	23	.	.	.
cord-299731-sis9952k	153	1	Despite	despite	IN
cord-299731-sis9952k	153	2	the	the	DT
cord-299731-sis9952k	153	3	underlying	underlying	JJ
cord-299731-sis9952k	153	4	DNA	dna	NN
cord-299731-sis9952k	153	5	repair	repair	NN
cord-299731-sis9952k	153	6	deficiencies	deficiency	NNS
cord-299731-sis9952k	153	7	,	,	,
cord-299731-sis9952k	153	8	NR	NR	NNP
cord-299731-sis9952k	153	9	could	could	MD
cord-299731-sis9952k	153	10	dramatically	dramatically	RB
cord-299731-sis9952k	153	11	improve	improve	VB
cord-299731-sis9952k	153	12	the	the	DT
cord-299731-sis9952k	153	13	phenotype	phenotype	NN
cord-299731-sis9952k	153	14	of	of	IN
cord-299731-sis9952k	153	15	each	each	DT
cord-299731-sis9952k	153	16	of	of	IN
cord-299731-sis9952k	153	17	these	these	DT
cord-299731-sis9952k	153	18	conditions	condition	NNS
cord-299731-sis9952k	153	19	in	in	IN
cord-299731-sis9952k	153	20	mouse	mouse	NN
cord-299731-sis9952k	153	21	models	model	NNS
cord-299731-sis9952k	153	22	,	,	,
cord-299731-sis9952k	153	23	while	while	IN
cord-299731-sis9952k	153	24	prolonging	prolong	VBG
cord-299731-sis9952k	153	25	survival	survival	NN
cord-299731-sis9952k	153	26	by	by	IN
cord-299731-sis9952k	153	27	more	more	JJR
cord-299731-sis9952k	153	28	than	than	IN
cord-299731-sis9952k	153	29	three	three	CD
cord-299731-sis9952k	153	30	times	time	NNS
cord-299731-sis9952k	153	31	in	in	IN
cord-299731-sis9952k	153	32	ataxic	ataxic	JJ
cord-299731-sis9952k	153	33	mice	mouse	NNS
cord-299731-sis9952k	153	34	[	[	-LRB-
cord-299731-sis9952k	153	35	95	95	CD
cord-299731-sis9952k	153	36	,	,	,
cord-299731-sis9952k	153	37	96	96	CD
cord-299731-sis9952k	153	38	]	]	-RRB-
cord-299731-sis9952k	153	39	.	.	.
cord-299731-sis9952k	154	1	Another	another	DT
cord-299731-sis9952k	154	2	early	early	JJ
cord-299731-sis9952k	154	3	event	event	NN
cord-299731-sis9952k	154	4	that	that	WDT
cord-299731-sis9952k	154	5	occurs	occur	VBZ
cord-299731-sis9952k	154	6	in	in	IN
cord-299731-sis9952k	154	7	acute	acute	JJ
cord-299731-sis9952k	154	8	cerebral	cerebral	JJ
cord-299731-sis9952k	154	9	injury	injury	NN
cord-299731-sis9952k	154	10	and	and	CC
cord-299731-sis9952k	154	11	in	in	IN
cord-299731-sis9952k	154	12	chronic	chronic	JJ
cord-299731-sis9952k	154	13	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	154	14	diseases	disease	NNS
cord-299731-sis9952k	154	15	,	,	,
cord-299731-sis9952k	154	16	including	include	VBG
cord-299731-sis9952k	154	17	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	154	18	's	's	POS
cord-299731-sis9952k	154	19	and	and	CC
cord-299731-sis9952k	154	20	Parkinson	Parkinson	NNP
cord-299731-sis9952k	154	21	's	's	POS
cord-299731-sis9952k	154	22	diseases	disease	NNS
cord-299731-sis9952k	154	23	,	,	,
cord-299731-sis9952k	154	24	is	be	VBZ
cord-299731-sis9952k	154	25	axonal	axonal	JJ
cord-299731-sis9952k	154	26	degeneration	degeneration	NN
cord-299731-sis9952k	154	27	[	[	-LRB-
cord-299731-sis9952k	154	28	97	97	CD
cord-299731-sis9952k	154	29	]	]	-RRB-
cord-299731-sis9952k	154	30	[	[	-LRB-
cord-299731-sis9952k	154	31	98	98	CD
cord-299731-sis9952k	154	32	]	]	-RRB-
cord-299731-sis9952k	155	1	[	[	-LRB-
cord-299731-sis9952k	155	2	99	99	CD
cord-299731-sis9952k	155	3	]	]	-RRB-
cord-299731-sis9952k	155	4	[	[	-LRB-
cord-299731-sis9952k	155	5	100	100	CD
cord-299731-sis9952k	155	6	]	]	-RRB-
cord-299731-sis9952k	155	7	.	.	.
cord-299731-sis9952k	156	1	In	in	IN
cord-299731-sis9952k	156	2	such	such	JJ
cord-299731-sis9952k	156	3	cases	case	NNS
cord-299731-sis9952k	156	4	,	,	,
cord-299731-sis9952k	156	5	axonal	axonal	JJ
cord-299731-sis9952k	156	6	degeneration	degeneration	NN
cord-299731-sis9952k	156	7	is	be	VBZ
cord-299731-sis9952k	156	8	caused	cause	VBN
cord-299731-sis9952k	156	9	by	by	IN
cord-299731-sis9952k	156	10	excitotoxicity	excitotoxicity	NN
cord-299731-sis9952k	156	11	,	,	,
cord-299731-sis9952k	156	12	which	which	WDT
cord-299731-sis9952k	156	13	is	be	VBZ
cord-299731-sis9952k	156	14	another	another	DT
cord-299731-sis9952k	156	15	feature	feature	NN
cord-299731-sis9952k	156	16	implicated	implicate	VBN
cord-299731-sis9952k	156	17	in	in	IN
cord-299731-sis9952k	156	18	most	most	JJS
cord-299731-sis9952k	156	19	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	156	20	disorders	disorder	NNS
cord-299731-sis9952k	156	21	that	that	WDT
cord-299731-sis9952k	156	22	affect	affect	VBP
cord-299731-sis9952k	156	23	the	the	DT
cord-299731-sis9952k	156	24	central	central	JJ
cord-299731-sis9952k	156	25	nervous	nervous	JJ
cord-299731-sis9952k	156	26	system	system	NN
cord-299731-sis9952k	156	27	.	.	.
cord-299731-sis9952k	157	1	Interestingly	interestingly	RB
cord-299731-sis9952k	157	2	,	,	,
cord-299731-sis9952k	157	3	a	a	DT
cord-299731-sis9952k	157	4	strong	strong	JJ
cord-299731-sis9952k	157	5	NAD	NAD	NNP
cord-299731-sis9952k	157	6	+	+	CC
cord-299731-sis9952k	157	7	depletion	depletion	NN
cord-299731-sis9952k	157	8	in	in	IN
cord-299731-sis9952k	157	9	neurons	neuron	NNS
cord-299731-sis9952k	157	10	has	have	VBZ
cord-299731-sis9952k	157	11	been	be	VBN
cord-299731-sis9952k	157	12	revealed	reveal	VBN
cord-299731-sis9952k	157	13	during	during	IN
cord-299731-sis9952k	157	14	excitotoxicity	excitotoxicity	NN
cord-299731-sis9952k	157	15	[	[	-LRB-
cord-299731-sis9952k	157	16	101	101	CD
cord-299731-sis9952k	157	17	]	]	-RRB-
cord-299731-sis9952k	157	18	[	[	-LRB-
cord-299731-sis9952k	157	19	102	102	CD
cord-299731-sis9952k	157	20	]	]	-RRB-
cord-299731-sis9952k	157	21	[	[	-LRB-
cord-299731-sis9952k	157	22	103	103	CD
cord-299731-sis9952k	157	23	]	]	-RRB-
cord-299731-sis9952k	157	24	[	[	-LRB-
cord-299731-sis9952k	157	25	104	104	CD
cord-299731-sis9952k	157	26	]	]	-RRB-
cord-299731-sis9952k	157	27	,	,	,
cord-299731-sis9952k	157	28	whereas	whereas	IN
cord-299731-sis9952k	157	29	mice	mouse	NNS
cord-299731-sis9952k	157	30	injected	inject	VBD
cord-299731-sis9952k	157	31	with	with	IN
cord-299731-sis9952k	157	32	NR	NR	NNP
cord-299731-sis9952k	157	33	were	be	VBD
cord-299731-sis9952k	157	34	protected	protect	VBN
cord-299731-sis9952k	157	35	from	from	IN
cord-299731-sis9952k	157	36	excitotoxicity	excitotoxicity	NN
cord-299731-sis9952k	157	37	-	-	HYPH
cord-299731-sis9952k	157	38	induced	induce	VBN
cord-299731-sis9952k	157	39	axonal	axonal	JJ
cord-299731-sis9952k	157	40	degeneration	degeneration	NN
cord-299731-sis9952k	157	41	[	[	-LRB-
cord-299731-sis9952k	157	42	105	105	CD
cord-299731-sis9952k	157	43	]	]	-RRB-
cord-299731-sis9952k	157	44	.	.	.
cord-299731-sis9952k	158	1	Among	among	IN
cord-299731-sis9952k	158	2	three	three	CD
cord-299731-sis9952k	158	3	tested	test	VBN
cord-299731-sis9952k	158	4	NAD	NAD	NNP
cord-299731-sis9952k	158	5	+	+	CC
cord-299731-sis9952k	158	6	precursors	precursor	NNS
cord-299731-sis9952k	158	7	(	(	-LRB-
cord-299731-sis9952k	158	8	NA	NA	NNP
cord-299731-sis9952k	158	9	,	,	,
cord-299731-sis9952k	158	10	NAM	NAM	NNP
cord-299731-sis9952k	158	11	,	,	,
cord-299731-sis9952k	158	12	and	and	CC
cord-299731-sis9952k	158	13	NR	NR	NNP
cord-299731-sis9952k	158	14	)	)	-RRB-
cord-299731-sis9952k	158	15	including	include	VBG
cord-299731-sis9952k	158	16	NAD	NAD	NNP
cord-299731-sis9952k	158	17	+	+	CC
cord-299731-sis9952k	158	18	,	,	,
cord-299731-sis9952k	158	19	only	only	RB
cord-299731-sis9952k	158	20	NR	NR	NNP
cord-299731-sis9952k	158	21	could	could	MD
cord-299731-sis9952k	158	22	prevent	prevent	VB
cord-299731-sis9952k	158	23	axonal	axonal	JJ
cord-299731-sis9952k	158	24	degeneration	degeneration	NN
cord-299731-sis9952k	158	25	by	by	IN
cord-299731-sis9952k	158	26	altering	alter	VBG
cord-299731-sis9952k	158	27	the	the	DT
cord-299731-sis9952k	158	28	local	local	JJ
cord-299731-sis9952k	158	29	NR	NR	NNP
cord-299731-sis9952k	158	30	metabolism	metabolism	NN
cord-299731-sis9952k	158	31	within	within	IN
cord-299731-sis9952k	158	32	the	the	DT
cord-299731-sis9952k	158	33	axon	axon	NN
cord-299731-sis9952k	158	34	[	[	-LRB-
cord-299731-sis9952k	158	35	105	105	CD
cord-299731-sis9952k	158	36	,	,	,
cord-299731-sis9952k	158	37	106	106	CD
cord-299731-sis9952k	158	38	]	]	-RRB-
cord-299731-sis9952k	158	39	.	.	.
cord-299731-sis9952k	159	1	Namely	namely	RB
cord-299731-sis9952k	159	2	,	,	,
cord-299731-sis9952k	159	3	NR	NR	NNP
cord-299731-sis9952k	159	4	prevented	prevent	VBD
cord-299731-sis9952k	159	5	nuclear	nuclear	JJ
cord-299731-sis9952k	159	6	condensation	condensation	NN
cord-299731-sis9952k	159	7	and	and	CC
cord-299731-sis9952k	159	8	axonal	axonal	JJ
cord-299731-sis9952k	159	9	degeneration	degeneration	NN
cord-299731-sis9952k	159	10	in	in	IN
cord-299731-sis9952k	159	11	neurons	neuron	NNS
cord-299731-sis9952k	159	12	of	of	IN
cord-299731-sis9952k	159	13	Nmrk2-KO	Nmrk2-KO	NNP
cord-299731-sis9952k	159	14	mice	mouse	NNS
cord-299731-sis9952k	159	15	,	,	,
cord-299731-sis9952k	159	16	by	by	IN
cord-299731-sis9952k	159	17	inducing	induce	VBG
cord-299731-sis9952k	159	18	Nmrk1	Nmrk1	NNP
cord-299731-sis9952k	159	19	[	[	-LRB-
cord-299731-sis9952k	159	20	105	105	CD
cord-299731-sis9952k	159	21	]	]	-RRB-
cord-299731-sis9952k	159	22	,	,	,
cord-299731-sis9952k	159	23	which	which	WDT
cord-299731-sis9952k	159	24	suggests	suggest	VBZ
cord-299731-sis9952k	159	25	that	that	IN
cord-299731-sis9952k	159	26	Nmrk1	Nmrk1	NNP
cord-299731-sis9952k	159	27	might	may	MD
cord-299731-sis9952k	159	28	be	be	VB
cord-299731-sis9952k	159	29	the	the	DT
cord-299731-sis9952k	159	30	key	key	JJ
cord-299731-sis9952k	159	31	mediator	mediator	NN
cord-299731-sis9952k	159	32	of	of	IN
cord-299731-sis9952k	159	33	the	the	DT
cord-299731-sis9952k	159	34	neuroprotective	neuroprotective	JJ
cord-299731-sis9952k	159	35	activity	activity	NN
cord-299731-sis9952k	159	36	of	of	IN
cord-299731-sis9952k	159	37	NR	NR	NNP
cord-299731-sis9952k	159	38	.	.	.
cord-299731-sis9952k	160	1	This	this	DT
cord-299731-sis9952k	160	2	neuroprotective	neuroprotective	JJ
cord-299731-sis9952k	160	3	effect	effect	NN
cord-299731-sis9952k	160	4	depends	depend	VBZ
cord-299731-sis9952k	160	5	on	on	IN
cord-299731-sis9952k	160	6	both	both	DT
cord-299731-sis9952k	160	7	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	160	8	and	and	CC
cord-299731-sis9952k	160	9	axonal	axonal	JJ
cord-299731-sis9952k	160	10	NAD	NAD	NNP
cord-299731-sis9952k	160	11	+	+	CC
cord-299731-sis9952k	160	12	content	content	NN
cord-299731-sis9952k	160	13	[	[	-LRB-
cord-299731-sis9952k	160	14	78	78	CD
cord-299731-sis9952k	160	15	]	]	-RRB-
cord-299731-sis9952k	160	16	.	.	.
cord-299731-sis9952k	161	1	At	at	IN
cord-299731-sis9952k	161	2	present	present	JJ
cord-299731-sis9952k	161	3	,	,	,
cord-299731-sis9952k	161	4	two	two	CD
cord-299731-sis9952k	161	5	possible	possible	JJ
cord-299731-sis9952k	161	6	mechanisms	mechanism	NNS
cord-299731-sis9952k	161	7	of	of	IN
cord-299731-sis9952k	161	8	neuroprotection	neuroprotection	NN
cord-299731-sis9952k	161	9	have	have	VBP
cord-299731-sis9952k	161	10	been	be	VBN
cord-299731-sis9952k	161	11	proposed	propose	VBN
cord-299731-sis9952k	161	12	:	:	:
cord-299731-sis9952k	161	13	increasing	increase	VBG
cord-299731-sis9952k	161	14	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	161	15	NAD	NAD	NNP
cord-299731-sis9952k	161	16	+	+	CC
cord-299731-sis9952k	161	17	to	to	TO
cord-299731-sis9952k	161	18	support	support	VB
cord-299731-sis9952k	161	19	SIRT3	SIRT3	NNS
cord-299731-sis9952k	161	20	[	[	-LRB-
cord-299731-sis9952k	161	21	77	77	CD
cord-299731-sis9952k	161	22	]	]	-RRB-
cord-299731-sis9952k	161	23	and	and	CC
cord-299731-sis9952k	161	24	preserving	preserve	VBG
cord-299731-sis9952k	161	25	axonal	axonal	JJ
cord-299731-sis9952k	161	26	NAD	NAD	NNP
cord-299731-sis9952k	161	27	+	+	CC
cord-299731-sis9952k	161	28	to	to	TO
cord-299731-sis9952k	161	29	supply	supply	VB
cord-299731-sis9952k	161	30	damage	damage	NN
cord-299731-sis9952k	161	31	-	-	HYPH
cord-299731-sis9952k	161	32	induced	induce	VBN
cord-299731-sis9952k	161	33	SARM1	SARM1	NNP
cord-299731-sis9952k	161	34	activation	activation	NN
cord-299731-sis9952k	161	35	[	[	-LRB-
cord-299731-sis9952k	161	36	107	107	CD
cord-299731-sis9952k	161	37	]	]	-RRB-
cord-299731-sis9952k	161	38	.	.	.
cord-299731-sis9952k	162	1	Via	via	IN
cord-299731-sis9952k	162	2	SIRT3	sirt3	NN
cord-299731-sis9952k	162	3	activation	activation	NN
cord-299731-sis9952k	162	4	,	,	,
cord-299731-sis9952k	162	5	a	a	DT
cord-299731-sis9952k	162	6	NR	nr	NN
cord-299731-sis9952k	162	7	-	-	HYPH
cord-299731-sis9952k	162	8	induced	induce	VBN
cord-299731-sis9952k	162	9	increase	increase	NN
cord-299731-sis9952k	162	10	in	in	IN
cord-299731-sis9952k	162	11	NAD	NAD	NNP
cord-299731-sis9952k	162	12	+	+	CC
cord-299731-sis9952k	162	13	levels	level	NNS
cord-299731-sis9952k	162	14	can	can	MD
cord-299731-sis9952k	162	15	have	have	VB
cord-299731-sis9952k	162	16	additional	additional	JJ
cord-299731-sis9952k	162	17	beneficial	beneficial	JJ
cord-299731-sis9952k	162	18	and	and	CC
cord-299731-sis9952k	162	19	possible	possible	JJ
cord-299731-sis9952k	162	20	therapeutic	therapeutic	JJ
cord-299731-sis9952k	162	21	effects	effect	NNS
cord-299731-sis9952k	162	22	.	.	.
cord-299731-sis9952k	163	1	Specifically	specifically	RB
cord-299731-sis9952k	163	2	,	,	,
cord-299731-sis9952k	163	3	NR	NR	NNP
cord-299731-sis9952k	163	4	has	have	VBZ
cord-299731-sis9952k	163	5	been	be	VBN
cord-299731-sis9952k	163	6	shown	show	VBN
cord-299731-sis9952k	163	7	to	to	TO
cord-299731-sis9952k	163	8	prevent	prevent	VB
cord-299731-sis9952k	163	9	noise	noise	NN
cord-299731-sis9952k	163	10	-	-	HYPH
cord-299731-sis9952k	163	11	induced	induce	VBN
cord-299731-sis9952k	163	12	hearing	hearing	NN
cord-299731-sis9952k	163	13	loss	loss	NN
cord-299731-sis9952k	163	14	and	and	CC
cord-299731-sis9952k	163	15	neurite	neurite	NN
cord-299731-sis9952k	163	16	retraction	retraction	NN
cord-299731-sis9952k	163	17	from	from	IN
cord-299731-sis9952k	163	18	hair	hair	NN
cord-299731-sis9952k	163	19	cells	cell	NNS
cord-299731-sis9952k	163	20	in	in	IN
cord-299731-sis9952k	163	21	the	the	DT
cord-299731-sis9952k	163	22	inner	inner	JJ
cord-299731-sis9952k	163	23	ear	ear	NN
cord-299731-sis9952k	163	24	through	through	IN
cord-299731-sis9952k	163	25	a	a	DT
cord-299731-sis9952k	163	26	SIRT3-dependent	SIRT3-dependent	NNP
cord-299731-sis9952k	163	27	mechanism	mechanism	NN
cord-299731-sis9952k	163	28	[	[	-LRB-
cord-299731-sis9952k	163	29	77	77	CD
cord-299731-sis9952k	163	30	]	]	-RRB-
cord-299731-sis9952k	163	31	.	.	.
cord-299731-sis9952k	164	1	Moreover	moreover	RB
cord-299731-sis9952k	164	2	,	,	,
cord-299731-sis9952k	164	3	SIRT3	SIRT3	NNS
cord-299731-sis9952k	164	4	and	and	CC
cord-299731-sis9952k	164	5	5	5	CD
cord-299731-sis9952k	164	6	are	be	VBP
cord-299731-sis9952k	164	7	both	both	DT
cord-299731-sis9952k	164	8	critical	critical	JJ
cord-299731-sis9952k	164	9	for	for	IN
cord-299731-sis9952k	164	10	the	the	DT
cord-299731-sis9952k	164	11	health	health	NN
cord-299731-sis9952k	164	12	of	of	IN
cord-299731-sis9952k	164	13	retinal	retinal	JJ
cord-299731-sis9952k	164	14	photoreceptors	photoreceptor	NNS
cord-299731-sis9952k	164	15	[	[	-LRB-
cord-299731-sis9952k	164	16	108	108	CD
cord-299731-sis9952k	164	17	]	]	-RRB-
cord-299731-sis9952k	164	18	.	.	.
cord-299731-sis9952k	165	1	SIRT3	SIRT3	NNP
cord-299731-sis9952k	165	2	activity	activity	NN
cord-299731-sis9952k	165	3	is	be	VBZ
cord-299731-sis9952k	165	4	sensitive	sensitive	JJ
cord-299731-sis9952k	165	5	to	to	IN
cord-299731-sis9952k	165	6	the	the	DT
cord-299731-sis9952k	165	7	reduction	reduction	NN
cord-299731-sis9952k	165	8	of	of	IN
cord-299731-sis9952k	165	9	NAD	NAD	NNP
cord-299731-sis9952k	165	10	+	+	CC
cord-299731-sis9952k	165	11	content	content	NN
cord-299731-sis9952k	165	12	that	that	WDT
cord-299731-sis9952k	165	13	has	have	VBZ
cord-299731-sis9952k	165	14	been	be	VBN
cord-299731-sis9952k	165	15	detected	detect	VBN
cord-299731-sis9952k	165	16	in	in	IN
cord-299731-sis9952k	165	17	multiple	multiple	JJ
cord-299731-sis9952k	165	18	disorders	disorder	NNS
cord-299731-sis9952k	165	19	with	with	IN
cord-299731-sis9952k	165	20	retinal	retinal	JJ
cord-299731-sis9952k	165	21	degeneration	degeneration	NN
cord-299731-sis9952k	165	22	,	,	,
cord-299731-sis9952k	165	23	including	include	VBG
cord-299731-sis9952k	165	24	age	age	NN
cord-299731-sis9952k	165	25	-	-	HYPH
cord-299731-sis9952k	165	26	associated	associate	VBN
cord-299731-sis9952k	165	27	dysfunction	dysfunction	NN
cord-299731-sis9952k	165	28	,	,	,
cord-299731-sis9952k	165	29	diabetic	diabetic	JJ
cord-299731-sis9952k	165	30	retinopathy	retinopathy	NN
cord-299731-sis9952k	165	31	,	,	,
cord-299731-sis9952k	165	32	and	and	CC
cord-299731-sis9952k	165	33	light	light	NN
cord-299731-sis9952k	165	34	-	-	HYPH
cord-299731-sis9952k	165	35	induced	induce	VBN
cord-299731-sis9952k	165	36	degeneration	degeneration	NN
cord-299731-sis9952k	165	37	in	in	IN
cord-299731-sis9952k	165	38	mice	mouse	NNS
cord-299731-sis9952k	165	39	[	[	-LRB-
cord-299731-sis9952k	165	40	108	108	CD
cord-299731-sis9952k	165	41	]	]	-RRB-
cord-299731-sis9952k	165	42	.	.	.
cord-299731-sis9952k	166	1	This	this	DT
cord-299731-sis9952k	166	2	suggests	suggest	VBZ
cord-299731-sis9952k	166	3	a	a	DT
cord-299731-sis9952k	166	4	potential	potential	JJ
cord-299731-sis9952k	166	5	therapeutic	therapeutic	JJ
cord-299731-sis9952k	166	6	treatment	treatment	NN
cord-299731-sis9952k	166	7	with	with	IN
cord-299731-sis9952k	166	8	NR	NR	NNP
cord-299731-sis9952k	166	9	for	for	IN
cord-299731-sis9952k	166	10	a	a	DT
cord-299731-sis9952k	166	11	variety	variety	NN
cord-299731-sis9952k	166	12	of	of	IN
cord-299731-sis9952k	166	13	disorders	disorder	NNS
cord-299731-sis9952k	166	14	that	that	WDT
cord-299731-sis9952k	166	15	include	include	VBP
cord-299731-sis9952k	166	16	photoreceptor	photoreceptor	NN
cord-299731-sis9952k	166	17	degeneration	degeneration	NN
cord-299731-sis9952k	166	18	.	.	.
cord-299731-sis9952k	167	1	Furthermore	furthermore	RB
cord-299731-sis9952k	167	2	,	,	,
cord-299731-sis9952k	167	3	a	a	DT
cord-299731-sis9952k	167	4	general	general	JJ
cord-299731-sis9952k	167	5	decrease	decrease	NN
cord-299731-sis9952k	167	6	in	in	IN
cord-299731-sis9952k	167	7	NAD	NAD	NNP
cord-299731-sis9952k	167	8	+	+	CC
cord-299731-sis9952k	167	9	levels	level	NNS
cord-299731-sis9952k	167	10	has	have	VBZ
cord-299731-sis9952k	167	11	been	be	VBN
cord-299731-sis9952k	167	12	observed	observe	VBN
cord-299731-sis9952k	167	13	in	in	IN
cord-299731-sis9952k	167	14	neuromuscular	neuromuscular	JJ
cord-299731-sis9952k	167	15	diseases	disease	NNS
cord-299731-sis9952k	167	16	which	which	WDT
cord-299731-sis9952k	167	17	are	be	VBP
cord-299731-sis9952k	167	18	often	often	RB
cord-299731-sis9952k	167	19	caused	cause	VBN
cord-299731-sis9952k	167	20	by	by	IN
cord-299731-sis9952k	167	21	inherited	inherit	VBN
cord-299731-sis9952k	167	22	mutations	mutation	NNS
cord-299731-sis9952k	167	23	that	that	WDT
cord-299731-sis9952k	167	24	lead	lead	VBP
cord-299731-sis9952k	167	25	to	to	IN
cord-299731-sis9952k	167	26	progressive	progressive	JJ
cord-299731-sis9952k	167	27	skeletal	skeletal	JJ
cord-299731-sis9952k	167	28	muscle	muscle	NN
cord-299731-sis9952k	167	29	weakness	weakness	NN
cord-299731-sis9952k	167	30	and	and	CC
cord-299731-sis9952k	167	31	degeneration	degeneration	NN
cord-299731-sis9952k	167	32	[	[	-LRB-
cord-299731-sis9952k	167	33	38	38	CD
cord-299731-sis9952k	167	34	]	]	-RRB-
cord-299731-sis9952k	167	35	.	.	.
cord-299731-sis9952k	168	1	Increasing	increase	VBG
cord-299731-sis9952k	168	2	NAD	NAD	NNP
cord-299731-sis9952k	168	3	+	+	CC
cord-299731-sis9952k	168	4	content	content	NN
cord-299731-sis9952k	168	5	with	with	IN
cord-299731-sis9952k	168	6	NR	NR	NNP
cord-299731-sis9952k	168	7	can	can	MD
cord-299731-sis9952k	168	8	stimulate	stimulate	VB
cord-299731-sis9952k	168	9	energy	energy	NN
cord-299731-sis9952k	168	10	production	production	NN
cord-299731-sis9952k	168	11	and	and	CC
cord-299731-sis9952k	168	12	improve	improve	VB
cord-299731-sis9952k	168	13	mitochondria	mitochondrion	NNS
cord-299731-sis9952k	168	14	function	function	VB
cord-299731-sis9952k	168	15	.	.	.
cord-299731-sis9952k	169	1	NR	NR	NNP
cord-299731-sis9952k	169	2	has	have	VBZ
cord-299731-sis9952k	169	3	been	be	VBN
cord-299731-sis9952k	169	4	shown	show	VBN
cord-299731-sis9952k	169	5	to	to	TO
cord-299731-sis9952k	169	6	have	have	VB
cord-299731-sis9952k	169	7	therapeutic	therapeutic	JJ
cord-299731-sis9952k	169	8	effects	effect	NNS
cord-299731-sis9952k	169	9	in	in	IN
cord-299731-sis9952k	169	10	several	several	JJ
cord-299731-sis9952k	169	11	muscle	muscle	NN
cord-299731-sis9952k	169	12	disorders	disorder	NNS
cord-299731-sis9952k	169	13	in	in	IN
cord-299731-sis9952k	169	14	mouse	mouse	NN
cord-299731-sis9952k	169	15	models	model	NNS
cord-299731-sis9952k	169	16	.	.	.
cord-299731-sis9952k	170	1	Although	although	IN
cord-299731-sis9952k	170	2	supplementation	supplementation	NN
cord-299731-sis9952k	170	3	with	with	IN
cord-299731-sis9952k	170	4	NR	NR	NNP
cord-299731-sis9952k	170	5	could	could	MD
cord-299731-sis9952k	170	6	not	not	RB
cord-299731-sis9952k	170	7	correct	correct	VB
cord-299731-sis9952k	170	8	the	the	DT
cord-299731-sis9952k	170	9	underlying	underlying	JJ
cord-299731-sis9952k	170	10	genetic	genetic	JJ
cord-299731-sis9952k	170	11	defects	defect	NNS
cord-299731-sis9952k	170	12	,	,	,
cord-299731-sis9952k	170	13	it	-PRON-	PRP
cord-299731-sis9952k	170	14	could	could	MD
cord-299731-sis9952k	170	15	improve	improve	VB
cord-299731-sis9952k	170	16	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	170	17	abundance	abundance	NN
cord-299731-sis9952k	170	18	and	and	CC
cord-299731-sis9952k	170	19	function	function	NN
cord-299731-sis9952k	170	20	in	in	IN
cord-299731-sis9952k	170	21	two	two	CD
cord-299731-sis9952k	170	22	different	different	JJ
cord-299731-sis9952k	170	23	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	170	24	myopathies	myopathy	NNS
cord-299731-sis9952k	170	25	[	[	-LRB-
cord-299731-sis9952k	170	26	109	109	CD
cord-299731-sis9952k	170	27	,	,	,
cord-299731-sis9952k	170	28	110	110	CD
cord-299731-sis9952k	170	29	]	]	-RRB-
cord-299731-sis9952k	170	30	.	.	.
cord-299731-sis9952k	171	1	Furthermore	furthermore	RB
cord-299731-sis9952k	171	2	,	,	,
cord-299731-sis9952k	171	3	NR	NR	NNP
cord-299731-sis9952k	171	4	could	could	MD
cord-299731-sis9952k	171	5	reverse	reverse	VB
cord-299731-sis9952k	171	6	the	the	DT
cord-299731-sis9952k	171	7	progressive	progressive	JJ
cord-299731-sis9952k	171	8	wasting	wasting	NN
cord-299731-sis9952k	171	9	syndrome	syndrome	NN
cord-299731-sis9952k	171	10	in	in	IN
cord-299731-sis9952k	171	11	skeletal	skeletal	JJ
cord-299731-sis9952k	171	12	muscle	muscle	NN
cord-299731-sis9952k	171	13	in	in	IN
cord-299731-sis9952k	171	14	mice	mouse	NNS
cord-299731-sis9952k	171	15	lacking	lack	VBG
cord-299731-sis9952k	171	16	Nampt	Nampt	NNP
cord-299731-sis9952k	171	17	whilst	whilst	IN
cord-299731-sis9952k	171	18	restoring	restore	VBG
cord-299731-sis9952k	171	19	endurance	endurance	NN
cord-299731-sis9952k	171	20	,	,	,
cord-299731-sis9952k	171	21	in	in	IN
cord-299731-sis9952k	171	22	as	as	RB
cord-299731-sis9952k	171	23	little	little	JJ
cord-299731-sis9952k	171	24	as	as	IN
cord-299731-sis9952k	171	25	1	1	CD
cord-299731-sis9952k	171	26	week	week	NN
cord-299731-sis9952k	171	27	of	of	IN
cord-299731-sis9952k	171	28	treatment	treatment	NN
cord-299731-sis9952k	171	29	[	[	-LRB-
cord-299731-sis9952k	171	30	111	111	CD
cord-299731-sis9952k	171	31	]	]	-RRB-
cord-299731-sis9952k	171	32	.	.	.
cord-299731-sis9952k	172	1	Accordingly	accordingly	RB
cord-299731-sis9952k	172	2	,	,	,
cord-299731-sis9952k	172	3	NR	NR	NNP
cord-299731-sis9952k	172	4	was	be	VBD
cord-299731-sis9952k	172	5	found	find	VBN
cord-299731-sis9952k	172	6	to	to	TO
cord-299731-sis9952k	172	7	confer	confer	VB
cord-299731-sis9952k	172	8	increased	increased	JJ
cord-299731-sis9952k	172	9	endurance	endurance	NN
cord-299731-sis9952k	172	10	and	and	CC
cord-299731-sis9952k	172	11	improved	improved	JJ
cord-299731-sis9952k	172	12	cold	cold	JJ
cord-299731-sis9952k	172	13	tolerance	tolerance	NN
cord-299731-sis9952k	172	14	in	in	IN
cord-299731-sis9952k	172	15	the	the	DT
cord-299731-sis9952k	172	16	HFD	HFD	NNP
cord-299731-sis9952k	172	17	-	-	HYPH
cord-299731-sis9952k	172	18	fed	feed	VBN
cord-299731-sis9952k	172	19	mice	mouse	NNS
cord-299731-sis9952k	172	20	.	.	.
cord-299731-sis9952k	173	1	However	however	RB
cord-299731-sis9952k	173	2	,	,	,
cord-299731-sis9952k	173	3	whether	whether	IN
cord-299731-sis9952k	173	4	NR	NR	NNP
cord-299731-sis9952k	173	5	has	have	VBZ
cord-299731-sis9952k	173	6	significant	significant	JJ
cord-299731-sis9952k	173	7	benefits	benefit	NNS
cord-299731-sis9952k	173	8	in	in	IN
cord-299731-sis9952k	173	9	lean	lean	JJ
cord-299731-sis9952k	173	10	,	,	,
cord-299731-sis9952k	173	11	healthy	healthy	JJ
cord-299731-sis9952k	173	12	muscle	muscle	NN
cord-299731-sis9952k	173	13	is	be	VBZ
cord-299731-sis9952k	173	14	less	less	RBR
cord-299731-sis9952k	173	15	clear	clear	JJ
cord-299731-sis9952k	173	16	,	,	,
cord-299731-sis9952k	173	17	as	as	IN
cord-299731-sis9952k	173	18	only	only	RB
cord-299731-sis9952k	173	19	a	a	DT
cord-299731-sis9952k	173	20	nonsignificant	nonsignificant	JJ
cord-299731-sis9952k	173	21	trend	trend	NN
cord-299731-sis9952k	173	22	toward	toward	IN
cord-299731-sis9952k	173	23	increased	increase	VBN
cord-299731-sis9952k	173	24	endurance	endurance	NN
cord-299731-sis9952k	173	25	was	be	VBD
cord-299731-sis9952k	173	26	observed	observe	VBN
cord-299731-sis9952k	173	27	in	in	IN
cord-299731-sis9952k	173	28	regular	regular	JJ
cord-299731-sis9952k	173	29	chow	chow	NN
cord-299731-sis9952k	173	30	-	-	HYPH
cord-299731-sis9952k	173	31	fed	feed	VBN
cord-299731-sis9952k	173	32	mice	mouse	NNS
cord-299731-sis9952k	173	33	[	[	-LRB-
cord-299731-sis9952k	173	34	37	37	CD
cord-299731-sis9952k	173	35	]	]	-RRB-
cord-299731-sis9952k	173	36	.	.	.
cord-299731-sis9952k	174	1	Interestingly	interestingly	RB
cord-299731-sis9952k	174	2	,	,	,
cord-299731-sis9952k	174	3	decreased	decrease	VBD
cord-299731-sis9952k	174	4	NAD	NAD	NNP
cord-299731-sis9952k	174	5	+	+	CC
cord-299731-sis9952k	174	6	levels	level	NNS
cord-299731-sis9952k	174	7	and	and	CC
cord-299731-sis9952k	174	8	Nampt	Nampt	NNP
cord-299731-sis9952k	174	9	expression	expression	NN
cord-299731-sis9952k	174	10	were	be	VBD
cord-299731-sis9952k	174	11	also	also	RB
cord-299731-sis9952k	174	12	observed	observe	VBN
cord-299731-sis9952k	174	13	in	in	IN
cord-299731-sis9952k	174	14	Duchenne	Duchenne	NNP
cord-299731-sis9952k	174	15	's	's	POS
cord-299731-sis9952k	174	16	muscular	muscular	JJ
cord-299731-sis9952k	174	17	dystrophy	dystrophy	NN
cord-299731-sis9952k	174	18	(	(	-LRB-
cord-299731-sis9952k	174	19	DMD	DMD	NNP
cord-299731-sis9952k	174	20	)	)	-RRB-
cord-299731-sis9952k	174	21	,	,	,
cord-299731-sis9952k	174	22	a	a	DT
cord-299731-sis9952k	174	23	condition	condition	NN
cord-299731-sis9952k	174	24	histologically	histologically	RB
cord-299731-sis9952k	174	25	and	and	CC
cord-299731-sis9952k	174	26	transcriptionally	transcriptionally	RB
cord-299731-sis9952k	174	27	similar	similar	JJ
cord-299731-sis9952k	174	28	to	to	IN
cord-299731-sis9952k	174	29	progressive	progressive	JJ
cord-299731-sis9952k	174	30	wasting	waste	VBG
cord-299731-sis9952k	174	31	syndrome	syndrome	NN
cord-299731-sis9952k	174	32	[	[	-LRB-
cord-299731-sis9952k	174	33	112	112	CD
cord-299731-sis9952k	174	34	,	,	,
cord-299731-sis9952k	174	35	113	113	CD
cord-299731-sis9952k	174	36	]	]	-RRB-
cord-299731-sis9952k	174	37	.	.	.
cord-299731-sis9952k	175	1	DMD	DMD	NNP
cord-299731-sis9952k	175	2	is	be	VBZ
cord-299731-sis9952k	175	3	also	also	RB
cord-299731-sis9952k	175	4	characterized	characterize	VBN
cord-299731-sis9952k	175	5	by	by	IN
cord-299731-sis9952k	175	6	increased	increase	VBN
cord-299731-sis9952k	175	7	PARP	PARP	NNP
cord-299731-sis9952k	175	8	activity	activity	NN
cord-299731-sis9952k	175	9	,	,	,
cord-299731-sis9952k	175	10	fibrosis	fibrosis	NN
cord-299731-sis9952k	175	11	,	,	,
cord-299731-sis9952k	175	12	and	and	CC
cord-299731-sis9952k	175	13	muscular	muscular	JJ
cord-299731-sis9952k	175	14	degeneration	degeneration	NN
cord-299731-sis9952k	175	15	.	.	.
cord-299731-sis9952k	176	1	NR	NR	NNP
cord-299731-sis9952k	176	2	was	be	VBD
cord-299731-sis9952k	176	3	found	find	VBN
cord-299731-sis9952k	176	4	to	to	TO
cord-299731-sis9952k	176	5	improve	improve	VB
cord-299731-sis9952k	176	6	muscular	muscular	JJ
cord-299731-sis9952k	176	7	function	function	NN
cord-299731-sis9952k	176	8	and	and	CC
cord-299731-sis9952k	176	9	heart	heart	NN
cord-299731-sis9952k	176	10	pathology	pathology	NN
cord-299731-sis9952k	176	11	in	in	IN
cord-299731-sis9952k	176	12	mdx	mdx	NNP
cord-299731-sis9952k	176	13	mice	mouse	NNS
cord-299731-sis9952k	176	14	models	model	NNS
cord-299731-sis9952k	176	15	of	of	IN
cord-299731-sis9952k	176	16	DMD	DMD	NNP
cord-299731-sis9952k	176	17	and	and	CC
cord-299731-sis9952k	176	18	decrease	decrease	VB
cord-299731-sis9952k	176	19	PARylation	parylation	NN
cord-299731-sis9952k	176	20	,	,	,
cord-299731-sis9952k	176	21	inflammation	inflammation	NN
cord-299731-sis9952k	176	22	,	,	,
cord-299731-sis9952k	176	23	and	and	CC
cord-299731-sis9952k	176	24	fibrosis	fibrosis	NN
cord-299731-sis9952k	176	25	[	[	-LRB-
cord-299731-sis9952k	176	26	112	112	CD
cord-299731-sis9952k	176	27	]	]	-RRB-
cord-299731-sis9952k	176	28	.	.	.
cord-299731-sis9952k	177	1	Moreover	moreover	RB
cord-299731-sis9952k	177	2	,	,	,
cord-299731-sis9952k	177	3	NR	NR	NNP
cord-299731-sis9952k	177	4	treatment	treatment	NN
cord-299731-sis9952k	177	5	has	have	VBZ
cord-299731-sis9952k	177	6	been	be	VBN
cord-299731-sis9952k	177	7	shown	show	VBN
cord-299731-sis9952k	177	8	to	to	TO
cord-299731-sis9952k	177	9	improve	improve	VB
cord-299731-sis9952k	177	10	stem	stem	NN
cord-299731-sis9952k	177	11	cell	cell	NN
cord-299731-sis9952k	177	12	function	function	NN
cord-299731-sis9952k	177	13	and	and	CC
cord-299731-sis9952k	177	14	thereby	thereby	RB
cord-299731-sis9952k	177	15	ameliorate	ameliorate	VB
cord-299731-sis9952k	177	16	the	the	DT
cord-299731-sis9952k	177	17	muscle	muscle	NN
cord-299731-sis9952k	177	18	wasting	waste	VBG
cord-299731-sis9952k	177	19	phenotype	phenotype	NN
cord-299731-sis9952k	177	20	in	in	IN
cord-299731-sis9952k	177	21	mdx	mdx	NNP
cord-299731-sis9952k	177	22	mice	mouse	NNS
cord-299731-sis9952k	177	23	,	,	,
cord-299731-sis9952k	177	24	supporting	support	VBG
cord-299731-sis9952k	177	25	the	the	DT
cord-299731-sis9952k	177	26	use	use	NN
cord-299731-sis9952k	177	27	of	of	IN
cord-299731-sis9952k	177	28	NR	NR	NNP
cord-299731-sis9952k	177	29	for	for	IN
cord-299731-sis9952k	177	30	the	the	DT
cord-299731-sis9952k	177	31	human	human	JJ
cord-299731-sis9952k	177	32	condition	condition	NN
cord-299731-sis9952k	177	33	[	[	-LRB-
cord-299731-sis9952k	177	34	38	38	CD
cord-299731-sis9952k	177	35	,	,	,
cord-299731-sis9952k	177	36	112	112	CD
cord-299731-sis9952k	177	37	]	]	-RRB-
cord-299731-sis9952k	177	38	.	.	.
cord-299731-sis9952k	178	1	Improvement	improvement	NN
cord-299731-sis9952k	178	2	in	in	IN
cord-299731-sis9952k	178	3	stem	stem	NN
cord-299731-sis9952k	178	4	cell	cell	NN
cord-299731-sis9952k	178	5	function	function	NN
cord-299731-sis9952k	178	6	appears	appear	VBZ
cord-299731-sis9952k	178	7	to	to	TO
cord-299731-sis9952k	178	8	be	be	VB
cord-299731-sis9952k	178	9	a	a	DT
cord-299731-sis9952k	178	10	general	general	JJ
cord-299731-sis9952k	178	11	phenomenon	phenomenon	NN
cord-299731-sis9952k	178	12	during	during	IN
cord-299731-sis9952k	178	13	NR	NR	NNP
cord-299731-sis9952k	178	14	treatment	treatment	NN
cord-299731-sis9952k	178	15	and	and	CC
cord-299731-sis9952k	178	16	has	have	VBZ
cord-299731-sis9952k	178	17	been	be	VBN
cord-299731-sis9952k	178	18	suggested	suggest	VBN
cord-299731-sis9952k	178	19	to	to	TO
cord-299731-sis9952k	178	20	underlie	underlie	VB
cord-299731-sis9952k	178	21	a	a	DT
cord-299731-sis9952k	178	22	small	small	JJ
cord-299731-sis9952k	178	23	,	,	,
cord-299731-sis9952k	178	24	but	but	CC
cord-299731-sis9952k	178	25	significant	significant	JJ
cord-299731-sis9952k	178	26	extension	extension	NN
cord-299731-sis9952k	178	27	of	of	IN
cord-299731-sis9952k	178	28	lifespan	lifespan	NN
cord-299731-sis9952k	178	29	in	in	IN
cord-299731-sis9952k	178	30	mice	mouse	NNS
cord-299731-sis9952k	178	31	[	[	-LRB-
cord-299731-sis9952k	178	32	38	38	CD
cord-299731-sis9952k	178	33	]	]	-RRB-
cord-299731-sis9952k	178	34	.	.	.
cord-299731-sis9952k	179	1	Altogether	altogether	RB
cord-299731-sis9952k	179	2	,	,	,
cord-299731-sis9952k	179	3	these	these	DT
cord-299731-sis9952k	179	4	findings	finding	NNS
cord-299731-sis9952k	179	5	support	support	VBP
cord-299731-sis9952k	179	6	that	that	IN
cord-299731-sis9952k	179	7	NR	NR	NNP
cord-299731-sis9952k	179	8	could	could	MD
cord-299731-sis9952k	179	9	be	be	VB
cord-299731-sis9952k	179	10	effective	effective	JJ
cord-299731-sis9952k	179	11	in	in	IN
cord-299731-sis9952k	179	12	managing	manage	VBG
cord-299731-sis9952k	179	13	the	the	DT
cord-299731-sis9952k	179	14	progression	progression	NN
cord-299731-sis9952k	179	15	of	of	IN
cord-299731-sis9952k	179	16	muscular	muscular	JJ
cord-299731-sis9952k	179	17	dystrophy	dystrophy	NN
cord-299731-sis9952k	179	18	and	and	CC
cord-299731-sis9952k	179	19	degeneration	degeneration	NN
cord-299731-sis9952k	179	20	,	,	,
cord-299731-sis9952k	179	21	by	by	IN
cord-299731-sis9952k	179	22	improving	improve	VBG
cord-299731-sis9952k	179	23	muscular	muscular	JJ
cord-299731-sis9952k	179	24	strength	strength	NN
cord-299731-sis9952k	179	25	,	,	,
cord-299731-sis9952k	179	26	rejuvenating	rejuvenate	VBG
cord-299731-sis9952k	179	27	senescent	senescent	JJ
cord-299731-sis9952k	179	28	muscle	muscle	NN
cord-299731-sis9952k	179	29	stem	stem	NN
cord-299731-sis9952k	179	30	cells	cell	NNS
cord-299731-sis9952k	179	31	,	,	,
cord-299731-sis9952k	179	32	and	and	CC
cord-299731-sis9952k	179	33	reducing	reduce	VBG
cord-299731-sis9952k	179	34	levels	level	NNS
cord-299731-sis9952k	179	35	of	of	IN
cord-299731-sis9952k	179	36	inflammation	inflammation	NN
cord-299731-sis9952k	179	37	and	and	CC
cord-299731-sis9952k	179	38	fibrosis	fibrosis	NN
cord-299731-sis9952k	179	39	.	.	.
cord-299731-sis9952k	180	1	Calorie	calorie	NN
cord-299731-sis9952k	180	2	restriction	restriction	NN
cord-299731-sis9952k	180	3	(	(	-LRB-
cord-299731-sis9952k	180	4	CR	CR	NNP
cord-299731-sis9952k	180	5	)	)	-RRB-
cord-299731-sis9952k	180	6	is	be	VBZ
cord-299731-sis9952k	180	7	considered	consider	VBN
cord-299731-sis9952k	180	8	the	the	DT
cord-299731-sis9952k	180	9	most	most	RBS
cord-299731-sis9952k	180	10	effective	effective	JJ
cord-299731-sis9952k	180	11	approach	approach	NN
cord-299731-sis9952k	180	12	to	to	TO
cord-299731-sis9952k	180	13	extend	extend	VB
cord-299731-sis9952k	180	14	lifespan	lifespan	NN
cord-299731-sis9952k	180	15	in	in	IN
cord-299731-sis9952k	180	16	eukaryotes	eukaryote	NNS
cord-299731-sis9952k	180	17	since	since	IN
cord-299731-sis9952k	180	18	the	the	DT
cord-299731-sis9952k	180	19	first	first	JJ
cord-299731-sis9952k	180	20	report	report	NN
cord-299731-sis9952k	180	21	of	of	IN
cord-299731-sis9952k	180	22	lifespan	lifespan	NNP
cord-299731-sis9952k	180	23	extension	extension	NN
cord-299731-sis9952k	180	24	in	in	IN
cord-299731-sis9952k	180	25	wild	wild	JJ
cord-299731-sis9952k	180	26	-	-	HYPH
cord-299731-sis9952k	180	27	type	type	NN
cord-299731-sis9952k	180	28	yeast	yeast	NN
cord-299731-sis9952k	180	29	cells	cell	NNS
cord-299731-sis9952k	180	30	via	via	IN
cord-299731-sis9952k	180	31	regulation	regulation	NN
cord-299731-sis9952k	180	32	of	of	IN
cord-299731-sis9952k	180	33	Sir2	Sir2	NNP
cord-299731-sis9952k	180	34	and	and	CC
cord-299731-sis9952k	180	35	NAD	NAD	NNP
cord-299731-sis9952k	180	36	+	+	CC
cord-299731-sis9952k	180	37	[	[	-LRB-
cord-299731-sis9952k	180	38	114	114	CD
cord-299731-sis9952k	180	39	]	]	-RRB-
cord-299731-sis9952k	180	40	.	.	.
cord-299731-sis9952k	181	1	CR	CR	NNP
cord-299731-sis9952k	181	2	life	life	NN
cord-299731-sis9952k	181	3	-	-	HYPH
cord-299731-sis9952k	181	4	prolonging	prolong	VBG
cord-299731-sis9952k	181	5	effects	effect	NNS
cord-299731-sis9952k	181	6	may	may	MD
cord-299731-sis9952k	181	7	partly	partly	RB
cord-299731-sis9952k	181	8	be	be	VB
cord-299731-sis9952k	181	9	mediated	mediate	VBN
cord-299731-sis9952k	181	10	via	via	IN
cord-299731-sis9952k	181	11	increased	increase	VBN
cord-299731-sis9952k	181	12	sirtuin	sirtuin	NN
cord-299731-sis9952k	181	13	function	function	NN
cord-299731-sis9952k	181	14	,	,	,
cord-299731-sis9952k	181	15	while	while	IN
cord-299731-sis9952k	181	16	the	the	DT
cord-299731-sis9952k	181	17	requirement	requirement	NN
cord-299731-sis9952k	181	18	of	of	IN
cord-299731-sis9952k	181	19	NAD	NAD	NNP
cord-299731-sis9952k	181	20	+	+	CC
cord-299731-sis9952k	181	21	for	for	IN
cord-299731-sis9952k	181	22	their	-PRON-	PRP$
cord-299731-sis9952k	181	23	activity	activity	NN
cord-299731-sis9952k	181	24	suggests	suggest	VBZ
cord-299731-sis9952k	181	25	a	a	DT
cord-299731-sis9952k	181	26	possible	possible	JJ
cord-299731-sis9952k	181	27	connection	connection	NN
cord-299731-sis9952k	181	28	between	between	IN
cord-299731-sis9952k	181	29	aging	aging	NN
cord-299731-sis9952k	181	30	and	and	CC
cord-299731-sis9952k	181	31	metabolism	metabolism	NN
cord-299731-sis9952k	181	32	.	.	.
cord-299731-sis9952k	182	1	However	however	RB
cord-299731-sis9952k	182	2	,	,	,
cord-299731-sis9952k	182	3	the	the	DT
cord-299731-sis9952k	182	4	nutritional	nutritional	JJ
cord-299731-sis9952k	182	5	approach	approach	NN
cord-299731-sis9952k	182	6	for	for	IN
cord-299731-sis9952k	182	7	increasing	increase	VBG
cord-299731-sis9952k	182	8	Sir2	Sir2	NNP
cord-299731-sis9952k	182	9	activity	activity	NN
cord-299731-sis9952k	182	10	and	and	CC
cord-299731-sis9952k	182	11	longevity	longevity	NN
cord-299731-sis9952k	182	12	has	have	VBZ
cord-299731-sis9952k	182	13	been	be	VBN
cord-299731-sis9952k	182	14	accomplished	accomplish	VBN
cord-299731-sis9952k	182	15	by	by	IN
cord-299731-sis9952k	182	16	engineered	engineer	VBN
cord-299731-sis9952k	182	17	gene	gene	NN
cord-299731-sis9952k	182	18	overexpression	overexpression	NN
cord-299731-sis9952k	182	19	in	in	IN
cord-299731-sis9952k	182	20	yeast	yeast	NN
cord-299731-sis9952k	182	21	[	[	-LRB-
cord-299731-sis9952k	182	22	115	115	CD
cord-299731-sis9952k	182	23	]	]	-RRB-
cord-299731-sis9952k	182	24	,	,	,
cord-299731-sis9952k	182	25	while	while	IN
cord-299731-sis9952k	182	26	NA	NA	NNP
cord-299731-sis9952k	182	27	failed	fail	VBD
cord-299731-sis9952k	182	28	to	to	TO
cord-299731-sis9952k	182	29	extend	extend	VB
cord-299731-sis9952k	182	30	lifespan	lifespan	NN
cord-299731-sis9952k	182	31	,	,	,
cord-299731-sis9952k	182	32	and	and	CC
cord-299731-sis9952k	182	33	NAM	NAM	NNP
cord-299731-sis9952k	182	34	shortened	shorten	VBD
cord-299731-sis9952k	182	35	it	-PRON-	PRP
cord-299731-sis9952k	182	36	[	[	-LRB-
cord-299731-sis9952k	182	37	116	116	CD
cord-299731-sis9952k	182	38	,	,	,
cord-299731-sis9952k	182	39	117	117	CD
cord-299731-sis9952k	182	40	]	]	-RRB-
cord-299731-sis9952k	182	41	.	.	.
cord-299731-sis9952k	183	1	On	on	IN
cord-299731-sis9952k	183	2	the	the	DT
cord-299731-sis9952k	183	3	other	other	JJ
cord-299731-sis9952k	183	4	hand	hand	NN
cord-299731-sis9952k	183	5	,	,	,
cord-299731-sis9952k	183	6	as	as	IN
cord-299731-sis9952k	183	7	with	with	IN
cord-299731-sis9952k	183	8	CR	CR	NNP
cord-299731-sis9952k	183	9	,	,	,
cord-299731-sis9952k	183	10	NR	NR	NNP
cord-299731-sis9952k	183	11	can	can	MD
cord-299731-sis9952k	183	12	increase	increase	VB
cord-299731-sis9952k	183	13	NAD	NAD	NNP
cord-299731-sis9952k	183	14	+	+	CC
cord-299731-sis9952k	183	15	levels	level	NNS
cord-299731-sis9952k	183	16	and	and	CC
cord-299731-sis9952k	183	17	Sir2	Sir2	NNP
cord-299731-sis9952k	183	18	function	function	NN
cord-299731-sis9952k	183	19	,	,	,
cord-299731-sis9952k	183	20	while	while	IN
cord-299731-sis9952k	183	21	exogenous	exogenous	JJ
cord-299731-sis9952k	183	22	NR	NR	NNP
cord-299731-sis9952k	183	23	promotes	promote	VBZ
cord-299731-sis9952k	183	24	Sir2-dependent	sir2-dependent	CD
cord-299731-sis9952k	183	25	repression	repression	NN
cord-299731-sis9952k	183	26	of	of	IN
cord-299731-sis9952k	183	27	recombination	recombination	NN
cord-299731-sis9952k	183	28	,	,	,
cord-299731-sis9952k	183	29	improves	improve	VBZ
cord-299731-sis9952k	183	30	gene	gene	NN
cord-299731-sis9952k	183	31	silencing	silencing	NN
cord-299731-sis9952k	183	32	,	,	,
cord-299731-sis9952k	183	33	and	and	CC
cord-299731-sis9952k	183	34	extends	extend	VBZ
cord-299731-sis9952k	183	35	lifespan	lifespan	NN
cord-299731-sis9952k	183	36	without	without	IN
cord-299731-sis9952k	183	37	calorie	calorie	NN
cord-299731-sis9952k	183	38	restriction	restriction	NN
cord-299731-sis9952k	183	39	[	[	-LRB-
cord-299731-sis9952k	183	40	11	11	CD
cord-299731-sis9952k	183	41	]	]	-RRB-
cord-299731-sis9952k	183	42	.	.	.
cord-299731-sis9952k	184	1	Moreover	moreover	RB
cord-299731-sis9952k	184	2	,	,	,
cord-299731-sis9952k	184	3	the	the	DT
cord-299731-sis9952k	184	4	mechanism	mechanism	NN
cord-299731-sis9952k	184	5	of	of	IN
cord-299731-sis9952k	184	6	action	action	NN
cord-299731-sis9952k	184	7	of	of	IN
cord-299731-sis9952k	184	8	NR	NR	NNP
cord-299731-sis9952k	184	9	is	be	VBZ
cord-299731-sis9952k	184	10	completely	completely	RB
cord-299731-sis9952k	184	11	dependent	dependent	JJ
cord-299731-sis9952k	184	12	on	on	IN
cord-299731-sis9952k	184	13	increased	increase	VBN
cord-299731-sis9952k	184	14	net	net	NN
cord-299731-sis9952k	184	15	NAD	NAD	NNP
cord-299731-sis9952k	184	16	+	+	CC
cord-299731-sis9952k	184	17	synthesis	synthesis	NN
cord-299731-sis9952k	184	18	through	through	IN
cord-299731-sis9952k	184	19	the	the	DT
cord-299731-sis9952k	184	20	Nrk1	Nrk1	NNP
cord-299731-sis9952k	184	21	and	and	CC
cord-299731-sis9952k	184	22	the	the	DT
cord-299731-sis9952k	184	23	Urh1	Urh1	NNP
cord-299731-sis9952k	184	24	/	/	SYM
cord-299731-sis9952k	184	25	Pnp1/4	Pnp1/4	VBN
cord-299731-sis9952k	184	26	pathways	pathway	NNS
cord-299731-sis9952k	184	27	.	.	.
cord-299731-sis9952k	185	1	The	the	DT
cord-299731-sis9952k	185	2	latter	latter	JJ
cord-299731-sis9952k	185	3	is	be	VBZ
cord-299731-sis9952k	185	4	Nrk1	Nrk1	NNP
cord-299731-sis9952k	185	5	independent	independent	JJ
cord-299731-sis9952k	185	6	and	and	CC
cord-299731-sis9952k	185	7	represents	represent	VBZ
cord-299731-sis9952k	185	8	a	a	DT
cord-299731-sis9952k	185	9	newly	newly	RB
cord-299731-sis9952k	185	10	discovered	discover	VBN
cord-299731-sis9952k	185	11	NR	NR	NNP
cord-299731-sis9952k	185	12	salvage	salvage	NN
cord-299731-sis9952k	185	13	pathway	pathway	NN
cord-299731-sis9952k	185	14	[	[	-LRB-
cord-299731-sis9952k	185	15	11	11	CD
cord-299731-sis9952k	185	16	]	]	-RRB-
cord-299731-sis9952k	185	17	.	.	.
cord-299731-sis9952k	186	1	Furthermore	furthermore	RB
cord-299731-sis9952k	186	2	,	,	,
cord-299731-sis9952k	186	3	a	a	DT
cord-299731-sis9952k	186	4	study	study	NN
cord-299731-sis9952k	186	5	in	in	IN
cord-299731-sis9952k	186	6	mouse	mouse	NN
cord-299731-sis9952k	186	7	models	model	NNS
cord-299731-sis9952k	186	8	documented	document	VBD
cord-299731-sis9952k	186	9	that	that	IN
cord-299731-sis9952k	186	10	a	a	DT
cord-299731-sis9952k	186	11	one	one	CD
cord-299731-sis9952k	186	12	-	-	HYPH
cord-299731-sis9952k	186	13	day	day	NN
cord-299731-sis9952k	186	14	fast	fast	NN
cord-299731-sis9952k	186	15	increases	increase	NNS
cord-299731-sis9952k	186	16	NAD	NAD	NNP
cord-299731-sis9952k	186	17	+	+	CC
cord-299731-sis9952k	186	18	in	in	IN
cord-299731-sis9952k	186	19	the	the	DT
cord-299731-sis9952k	186	20	liver	liver	NN
cord-299731-sis9952k	186	21	[	[	-LRB-
cord-299731-sis9952k	186	22	118	118	CD
cord-299731-sis9952k	186	23	]	]	-RRB-
cord-299731-sis9952k	186	24	whereas	whereas	IN
cord-299731-sis9952k	186	25	CR	CR	NNP
cord-299731-sis9952k	186	26	elevates	elevate	VBZ
cord-299731-sis9952k	186	27	NAD	NAD	NNP
cord-299731-sis9952k	186	28	+	+	CC
cord-299731-sis9952k	186	29	and	and	CC
cord-299731-sis9952k	186	30	reduces	reduce	VBZ
cord-299731-sis9952k	186	31	NAM	NAM	NNP
cord-299731-sis9952k	186	32	in	in	IN
cord-299731-sis9952k	186	33	the	the	DT
cord-299731-sis9952k	186	34	brain	brain	NN
cord-299731-sis9952k	186	35	[	[	-LRB-
cord-299731-sis9952k	186	36	119	119	CD
cord-299731-sis9952k	186	37	]	]	-RRB-
cord-299731-sis9952k	186	38	.	.	.
cord-299731-sis9952k	187	1	This	this	DT
cord-299731-sis9952k	187	2	implies	imply	VBZ
cord-299731-sis9952k	187	3	that	that	IN
cord-299731-sis9952k	187	4	the	the	DT
cord-299731-sis9952k	187	5	increased	increase	VBN
cord-299731-sis9952k	187	6	levels	level	NNS
cord-299731-sis9952k	187	7	of	of	IN
cord-299731-sis9952k	187	8	NAD	NAD	NNP
cord-299731-sis9952k	187	9	+	+	CC
cord-299731-sis9952k	187	10	appear	appear	VBP
cord-299731-sis9952k	187	11	to	to	TO
cord-299731-sis9952k	187	12	mediate	mediate	VB
cord-299731-sis9952k	187	13	several	several	JJ
cord-299731-sis9952k	187	14	beneficial	beneficial	JJ
cord-299731-sis9952k	187	15	effects	effect	NNS
cord-299731-sis9952k	187	16	of	of	IN
cord-299731-sis9952k	187	17	CR	cr	NN
cord-299731-sis9952k	187	18	,	,	,
cord-299731-sis9952k	187	19	supporting	support	VBG
cord-299731-sis9952k	187	20	the	the	DT
cord-299731-sis9952k	187	21	life	life	NN
cord-299731-sis9952k	187	22	-	-	HYPH
cord-299731-sis9952k	187	23	prolonging	prolong	VBG
cord-299731-sis9952k	187	24	effects	effect	NNS
cord-299731-sis9952k	187	25	of	of	IN
cord-299731-sis9952k	187	26	NR	NR	NNP
cord-299731-sis9952k	187	27	supplementation	supplementation	NN
cord-299731-sis9952k	187	28	.	.	.
cord-299731-sis9952k	188	1	These	these	DT
cord-299731-sis9952k	188	2	effects	effect	NNS
cord-299731-sis9952k	188	3	are	be	VBP
cord-299731-sis9952k	188	4	mediated	mediate	VBN
cord-299731-sis9952k	188	5	via	via	IN
cord-299731-sis9952k	188	6	improvement	improvement	NN
cord-299731-sis9952k	188	7	of	of	IN
cord-299731-sis9952k	188	8	metabolism	metabolism	NN
cord-299731-sis9952k	188	9	and	and	CC
cord-299731-sis9952k	188	10	decrease	decrease	NN
cord-299731-sis9952k	188	11	in	in	IN
cord-299731-sis9952k	188	12	chronic	chronic	JJ
cord-299731-sis9952k	188	13	inflammation	inflammation	NN
cord-299731-sis9952k	188	14	,	,	,
cord-299731-sis9952k	188	15	a	a	DT
cord-299731-sis9952k	188	16	hallmark	hallmark	NN
cord-299731-sis9952k	188	17	of	of	IN
cord-299731-sis9952k	188	18	aging	age	VBG
cord-299731-sis9952k	188	19	[	[	-LRB-
cord-299731-sis9952k	188	20	35	35	CD
cord-299731-sis9952k	188	21	]	]	-RRB-
cord-299731-sis9952k	188	22	.	.	.
cord-299731-sis9952k	189	1	Preclinical	preclinical	JJ
cord-299731-sis9952k	189	2	studies	study	NNS
cord-299731-sis9952k	189	3	have	have	VBP
cord-299731-sis9952k	189	4	reported	report	VBN
cord-299731-sis9952k	189	5	that	that	IN
cord-299731-sis9952k	189	6	NR	NR	NNP
cord-299731-sis9952k	189	7	reduces	reduce	VBZ
cord-299731-sis9952k	189	8	macrophage	macrophage	NN
cord-299731-sis9952k	189	9	infiltration	infiltration	NN
cord-299731-sis9952k	189	10	in	in	IN
cord-299731-sis9952k	189	11	damaged	damage	VBN
cord-299731-sis9952k	189	12	muscles	muscle	NNS
cord-299731-sis9952k	189	13	[	[	-LRB-
cord-299731-sis9952k	189	14	38	38	CD
cord-299731-sis9952k	189	15	,	,	,
cord-299731-sis9952k	189	16	112	112	CD
cord-299731-sis9952k	189	17	]	]	-RRB-
cord-299731-sis9952k	189	18	and	and	CC
cord-299731-sis9952k	189	19	attenuates	attenuate	VBZ
cord-299731-sis9952k	189	20	plasma	plasma	NN
cord-299731-sis9952k	189	21	TNF	TNF	NNP
cord-299731-sis9952k	189	22	-	-	HYPH
cord-299731-sis9952k	189	23	α	α	NN
cord-299731-sis9952k	189	24	in	in	IN
cord-299731-sis9952k	189	25	models	model	NNS
cord-299731-sis9952k	189	26	of	of	IN
cord-299731-sis9952k	189	27	fatty	fatty	JJ
cord-299731-sis9952k	189	28	liver	liver	NN
cord-299731-sis9952k	189	29	disease	disease	NN
cord-299731-sis9952k	189	30	[	[	-LRB-
cord-299731-sis9952k	189	31	44	44	CD
cord-299731-sis9952k	189	32	]	]	-RRB-
cord-299731-sis9952k	189	33	.	.	.
cord-299731-sis9952k	190	1	Nevertheless	nevertheless	RB
cord-299731-sis9952k	190	2	,	,	,
cord-299731-sis9952k	190	3	a	a	DT
cord-299731-sis9952k	190	4	recent	recent	JJ
cord-299731-sis9952k	190	5	clinical	clinical	JJ
cord-299731-sis9952k	190	6	study	study	NN
cord-299731-sis9952k	190	7	confirmed	confirm	VBD
cord-299731-sis9952k	190	8	NR	NR	NNP
cord-299731-sis9952k	190	9	availability	availability	NN
cord-299731-sis9952k	190	10	in	in	IN
cord-299731-sis9952k	190	11	muscular	muscular	JJ
cord-299731-sis9952k	190	12	tissue	tissue	NN
cord-299731-sis9952k	190	13	in	in	IN
cord-299731-sis9952k	190	14	aged	aged	JJ
cord-299731-sis9952k	190	15	human	human	JJ
cord-299731-sis9952k	190	16	subjects	subject	NNS
cord-299731-sis9952k	190	17	[	[	-LRB-
cord-299731-sis9952k	190	18	120	120	CD
cord-299731-sis9952k	190	19	]	]	-RRB-
cord-299731-sis9952k	190	20	and	and	CC
cord-299731-sis9952k	190	21	its	-PRON-	PRP$
cord-299731-sis9952k	190	22	anti	anti	JJ
cord-299731-sis9952k	190	23	-	-	JJ
cord-299731-sis9952k	190	24	inflammatory	inflammatory	JJ
cord-299731-sis9952k	190	25	effects	effect	NNS
cord-299731-sis9952k	190	26	.	.	.
cord-299731-sis9952k	191	1	Namely	namely	RB
cord-299731-sis9952k	191	2	,	,	,
cord-299731-sis9952k	191	3	a	a	DT
cord-299731-sis9952k	191	4	21-day	21-day	CD
cord-299731-sis9952k	191	5	supplementation	supplementation	NN
cord-299731-sis9952k	191	6	of	of	IN
cord-299731-sis9952k	191	7	NR	NR	NNP
cord-299731-sis9952k	191	8	decreased	decrease	VBD
cord-299731-sis9952k	191	9	numerous	numerous	JJ
cord-299731-sis9952k	191	10	circulating	circulate	VBG
cord-299731-sis9952k	191	11	inflammatory	inflammatory	JJ
cord-299731-sis9952k	191	12	cytokines	cytokine	NNS
cord-299731-sis9952k	191	13	[	[	-LRB-
cord-299731-sis9952k	191	14	120	120	CD
cord-299731-sis9952k	191	15	]	]	-RRB-
cord-299731-sis9952k	191	16	,	,	,
cord-299731-sis9952k	191	17	implying	imply	VBG
cord-299731-sis9952k	191	18	additional	additional	JJ
cord-299731-sis9952k	191	19	mechanisms	mechanism	NNS
cord-299731-sis9952k	191	20	through	through	IN
cord-299731-sis9952k	191	21	which	which	WDT
cord-299731-sis9952k	191	22	NR	nr	NN
cord-299731-sis9952k	191	23	can	can	MD
cord-299731-sis9952k	191	24	potentially	potentially	RB
cord-299731-sis9952k	191	25	modulate	modulate	VB
cord-299731-sis9952k	191	26	the	the	DT
cord-299731-sis9952k	191	27	aging	aging	NN
cord-299731-sis9952k	191	28	process	process	NN
cord-299731-sis9952k	191	29	and	and	CC
cord-299731-sis9952k	191	30	thereby	thereby	RB
cord-299731-sis9952k	191	31	exhibit	exhibit	VB
cord-299731-sis9952k	191	32	life	life	NN
cord-299731-sis9952k	191	33	-	-	HYPH
cord-299731-sis9952k	191	34	prolonging	prolong	VBG
cord-299731-sis9952k	191	35	effects	effect	NNS
cord-299731-sis9952k	191	36	.	.	.
cord-299731-sis9952k	192	1	While	while	IN
cord-299731-sis9952k	192	2	the	the	DT
cord-299731-sis9952k	192	3	exact	exact	JJ
cord-299731-sis9952k	192	4	mechanisms	mechanism	NNS
cord-299731-sis9952k	192	5	through	through	IN
cord-299731-sis9952k	192	6	which	which	WDT
cord-299731-sis9952k	192	7	NR	NR	NNP
cord-299731-sis9952k	192	8	exerts	exert	VBZ
cord-299731-sis9952k	192	9	these	these	DT
cord-299731-sis9952k	192	10	effects	effect	NNS
cord-299731-sis9952k	192	11	remain	remain	VBP
cord-299731-sis9952k	192	12	unclear	unclear	JJ
cord-299731-sis9952k	192	13	,	,	,
cord-299731-sis9952k	192	14	the	the	DT
cord-299731-sis9952k	192	15	apparent	apparent	JJ
cord-299731-sis9952k	192	16	health	health	NN
cord-299731-sis9952k	192	17	benefits	benefit	NNS
cord-299731-sis9952k	192	18	described	describe	VBN
cord-299731-sis9952k	192	19	indicate	indicate	VBP
cord-299731-sis9952k	192	20	positive	positive	JJ
cord-299731-sis9952k	192	21	effects	effect	NNS
cord-299731-sis9952k	192	22	of	of	IN
cord-299731-sis9952k	192	23	NR	nr	NN
cord-299731-sis9952k	192	24	on	on	IN
cord-299731-sis9952k	192	25	longevity	longevity	NN
cord-299731-sis9952k	192	26	.	.	.
cord-299731-sis9952k	193	1	NAD	NAD	NNP
cord-299731-sis9952k	193	2	+	+	CC
cord-299731-sis9952k	193	3	intermediates	intermediate	NNS
cord-299731-sis9952k	193	4	have	have	VBP
cord-299731-sis9952k	193	5	been	be	VBN
cord-299731-sis9952k	193	6	recognized	recognize	VBN
cord-299731-sis9952k	193	7	for	for	IN
cord-299731-sis9952k	193	8	their	-PRON-	PRP$
cord-299731-sis9952k	193	9	beneficial	beneficial	JJ
cord-299731-sis9952k	193	10	health	health	NN
cord-299731-sis9952k	193	11	effects	effect	NNS
cord-299731-sis9952k	193	12	during	during	IN
cord-299731-sis9952k	193	13	infection	infection	NN
cord-299731-sis9952k	193	14	with	with	IN
cord-299731-sis9952k	193	15	several	several	JJ
cord-299731-sis9952k	193	16	pathogens	pathogen	NNS
cord-299731-sis9952k	193	17	.	.	.
cord-299731-sis9952k	194	1	Studies	study	NNS
cord-299731-sis9952k	194	2	have	have	VBP
cord-299731-sis9952k	194	3	confirmed	confirm	VBN
cord-299731-sis9952k	194	4	antimycobacterial	antimycobacterial	JJ
cord-299731-sis9952k	194	5	effect	effect	NN
cord-299731-sis9952k	194	6	of	of	IN
cord-299731-sis9952k	194	7	NAM	NAM	NNP
cord-299731-sis9952k	194	8	in	in	IN
cord-299731-sis9952k	194	9	patients	patient	NNS
cord-299731-sis9952k	194	10	infected	infect	VBN
cord-299731-sis9952k	194	11	with	with	IN
cord-299731-sis9952k	194	12	Mycobacterium	Mycobacterium	NNP
cord-299731-sis9952k	194	13	tuberculosis	tuberculosis	NN
cord-299731-sis9952k	194	14	[	[	-LRB-
cord-299731-sis9952k	194	15	121	121	CD
cord-299731-sis9952k	194	16	,	,	,
cord-299731-sis9952k	194	17	122	122	CD
cord-299731-sis9952k	194	18	]	]	-RRB-
cord-299731-sis9952k	194	19	,	,	,
cord-299731-sis9952k	194	20	while	while	IN
cord-299731-sis9952k	194	21	immune	immune	NN
cord-299731-sis9952k	194	22	-	-	HYPH
cord-299731-sis9952k	194	23	mediated	mediate	VBN
cord-299731-sis9952k	194	24	elimination	elimination	NN
cord-299731-sis9952k	194	25	was	be	VBD
cord-299731-sis9952k	194	26	reported	report	VBN
cord-299731-sis9952k	194	27	for	for	IN
cord-299731-sis9952k	194	28	Staphylococcus	Staphylococcus	NNP
cord-299731-sis9952k	194	29	aureus	aureus	NN
cord-299731-sis9952k	194	30	,	,	,
cord-299731-sis9952k	194	31	including	include	VBG
cord-299731-sis9952k	194	32	MRSA	MRSA	NNP
cord-299731-sis9952k	194	33	and	and	CC
cord-299731-sis9952k	194	34	other	other	JJ
cord-299731-sis9952k	194	35	major	major	JJ
cord-299731-sis9952k	194	36	human	human	JJ
cord-299731-sis9952k	194	37	pathogens	pathogen	NNS
cord-299731-sis9952k	194	38	such	such	JJ
cord-299731-sis9952k	194	39	as	as	IN
cord-299731-sis9952k	194	40	Klebsiella	Klebsiella	NNP
cord-299731-sis9952k	194	41	pneumoniae	pneumoniae	NN
cord-299731-sis9952k	194	42	and	and	CC
cord-299731-sis9952k	194	43	Pseudomonas	Pseudomonas	NNP
cord-299731-sis9952k	194	44	aeruginosa	aeruginosa	VBZ
cord-299731-sis9952k	194	45	[	[	-LRB-
cord-299731-sis9952k	194	46	123	123	CD
cord-299731-sis9952k	194	47	]	]	-RRB-
cord-299731-sis9952k	194	48	.	.	.
cord-299731-sis9952k	195	1	In	in	IN
cord-299731-sis9952k	195	2	addition	addition	NN
cord-299731-sis9952k	195	3	,	,	,
cord-299731-sis9952k	195	4	NAM	NAM	NNP
cord-299731-sis9952k	195	5	and	and	CC
cord-299731-sis9952k	195	6	its	-PRON-	PRP$
cord-299731-sis9952k	195	7	analogues	analogue	NNS
cord-299731-sis9952k	195	8	exhibited	exhibit	VBD
cord-299731-sis9952k	195	9	antiviral	antiviral	JJ
cord-299731-sis9952k	195	10	effect	effect	NN
cord-299731-sis9952k	195	11	in	in	IN
cord-299731-sis9952k	195	12	patients	patient	NNS
cord-299731-sis9952k	195	13	with	with	IN
cord-299731-sis9952k	195	14	HIV	HIV	NNP
cord-299731-sis9952k	195	15	[	[	-LRB-
cord-299731-sis9952k	195	16	121	121	CD
cord-299731-sis9952k	195	17	]	]	-RRB-
cord-299731-sis9952k	195	18	and	and	CC
cord-299731-sis9952k	195	19	hepatitis	hepatitis	NN
cord-299731-sis9952k	195	20	B	B	NNP
cord-299731-sis9952k	195	21	[	[	-LRB-
cord-299731-sis9952k	195	22	124	124	CD
cord-299731-sis9952k	195	23	]	]	-RRB-
cord-299731-sis9952k	195	24	.	.	.
cord-299731-sis9952k	196	1	The	the	DT
cord-299731-sis9952k	196	2	potential	potential	JJ
cord-299731-sis9952k	196	3	treatment	treatment	NN
cord-299731-sis9952k	196	4	with	with	IN
cord-299731-sis9952k	196	5	NAD	NAD	NNP
cord-299731-sis9952k	196	6	+	+	CC
cord-299731-sis9952k	196	7	intermediates	intermediate	NNS
cord-299731-sis9952k	196	8	has	have	VBZ
cord-299731-sis9952k	196	9	been	be	VBN
cord-299731-sis9952k	196	10	recognized	recognize	VBN
cord-299731-sis9952k	196	11	recently	recently	RB
cord-299731-sis9952k	196	12	for	for	IN
cord-299731-sis9952k	196	13	combating	combat	VBG
cord-299731-sis9952k	196	14	COVID-19	covid-19	DT
cord-299731-sis9952k	196	15	infection	infection	NN
cord-299731-sis9952k	196	16	that	that	WDT
cord-299731-sis9952k	196	17	currently	currently	RB
cord-299731-sis9952k	196	18	lacks	lack	VBZ
cord-299731-sis9952k	196	19	efficient	efficient	JJ
cord-299731-sis9952k	196	20	therapeutic	therapeutic	JJ
cord-299731-sis9952k	196	21	or	or	CC
cord-299731-sis9952k	196	22	preventive	preventive	JJ
cord-299731-sis9952k	196	23	agents	agent	NNS
cord-299731-sis9952k	196	24	and	and	CC
cord-299731-sis9952k	196	25	represents	represent	VBZ
cord-299731-sis9952k	196	26	a	a	DT
cord-299731-sis9952k	196	27	global	global	JJ
cord-299731-sis9952k	196	28	concern	concern	NN
cord-299731-sis9952k	196	29	for	for	IN
cord-299731-sis9952k	196	30	public	public	JJ
cord-299731-sis9952k	196	31	health	health	NN
cord-299731-sis9952k	196	32	.	.	.
cord-299731-sis9952k	197	1	SARS	SARS	NNP
cord-299731-sis9952k	197	2	-	-	HYPH
cord-299731-sis9952k	197	3	CoV-2	CoV-2	NNP
cord-299731-sis9952k	197	4	infection	infection	NN
cord-299731-sis9952k	197	5	triggers	trigger	VBZ
cord-299731-sis9952k	197	6	a	a	DT
cord-299731-sis9952k	197	7	maladaptive	maladaptive	JJ
cord-299731-sis9952k	197	8	immune	immune	JJ
cord-299731-sis9952k	197	9	response	response	NN
cord-299731-sis9952k	197	10	.	.	.
cord-299731-sis9952k	198	1	Notably	notably	RB
cord-299731-sis9952k	198	2	an	an	DT
cord-299731-sis9952k	198	3	exaggerated	exaggerated	JJ
cord-299731-sis9952k	198	4	proinflammatory	proinflammatory	JJ
cord-299731-sis9952k	198	5	response	response	NN
cord-299731-sis9952k	198	6	leading	lead	VBG
cord-299731-sis9952k	198	7	to	to	IN
cord-299731-sis9952k	198	8	a	a	DT
cord-299731-sis9952k	198	9	"	"	``
cord-299731-sis9952k	198	10	cytokine	cytokine	NN
cord-299731-sis9952k	198	11	storm	storm	NN
cord-299731-sis9952k	198	12	"	"	''
cord-299731-sis9952k	198	13	in	in	IN
cord-299731-sis9952k	198	14	the	the	DT
cord-299731-sis9952k	198	15	lung	lung	NN
cord-299731-sis9952k	198	16	tissue	tissue	NN
cord-299731-sis9952k	198	17	,	,	,
cord-299731-sis9952k	198	18	and	and	CC
cord-299731-sis9952k	198	19	lymphopenia	lymphopenia	VBD
cord-299731-sis9952k	198	20	with	with	IN
cord-299731-sis9952k	198	21	a	a	DT
cord-299731-sis9952k	198	22	drastic	drastic	JJ
cord-299731-sis9952k	198	23	decline	decline	NN
cord-299731-sis9952k	198	24	of	of	IN
cord-299731-sis9952k	198	25	CD4	CD4	NNP
cord-299731-sis9952k	198	26	+	+	CC
cord-299731-sis9952k	198	27	and	and	CC
cord-299731-sis9952k	198	28	CD8	CD8	NNP
cord-299731-sis9952k	198	29	+	+	CC
cord-299731-sis9952k	198	30	T	T	NNP
cord-299731-sis9952k	198	31	cells	cell	NNS
cord-299731-sis9952k	198	32	[	[	-LRB-
cord-299731-sis9952k	198	33	125	125	CD
cord-299731-sis9952k	198	34	]	]	-RRB-
cord-299731-sis9952k	198	35	.	.	.
cord-299731-sis9952k	199	1	On	on	IN
cord-299731-sis9952k	199	2	the	the	DT
cord-299731-sis9952k	199	3	molecular	molecular	JJ
cord-299731-sis9952k	199	4	level	level	NN
cord-299731-sis9952k	199	5	,	,	,
cord-299731-sis9952k	199	6	as	as	IN
cord-299731-sis9952k	199	7	the	the	DT
cord-299731-sis9952k	199	8	innate	innate	JJ
cord-299731-sis9952k	199	9	immune	immune	JJ
cord-299731-sis9952k	199	10	response	response	NN
cord-299731-sis9952k	199	11	activates	activate	VBZ
cord-299731-sis9952k	199	12	to	to	TO
cord-299731-sis9952k	199	13	fight	fight	VB
cord-299731-sis9952k	199	14	the	the	DT
cord-299731-sis9952k	199	15	infection	infection	NN
cord-299731-sis9952k	199	16	,	,	,
cord-299731-sis9952k	199	17	the	the	DT
cord-299731-sis9952k	199	18	activation	activation	NN
cord-299731-sis9952k	199	19	of	of	IN
cord-299731-sis9952k	199	20	PARPs	PARPs	NNPS
cord-299731-sis9952k	199	21	increases	increase	NNS
cord-299731-sis9952k	199	22	due	due	JJ
cord-299731-sis9952k	199	23	to	to	IN
cord-299731-sis9952k	199	24	extensive	extensive	JJ
cord-299731-sis9952k	199	25	DNA	dna	NN
cord-299731-sis9952k	199	26	damage	damage	NN
cord-299731-sis9952k	199	27	and	and	CC
cord-299731-sis9952k	199	28	IFN	IFN	NNP
cord-299731-sis9952k	199	29	-	-	HYPH
cord-299731-sis9952k	199	30	induced	induce	VBN
cord-299731-sis9952k	199	31	MARylation	marylation	NN
cord-299731-sis9952k	200	1	(	(	-LRB-
cord-299731-sis9952k	200	2	mono	mono	JJ
cord-299731-sis9952k	200	3	-	-	HYPH
cord-299731-sis9952k	200	4	ADP	adp	NN
cord-299731-sis9952k	200	5	-	-	HYPH
cord-299731-sis9952k	200	6	ribosylation	ribosylation	NN
cord-299731-sis9952k	200	7	)	)	-RRB-
cord-299731-sis9952k	200	8	of	of	IN
cord-299731-sis9952k	200	9	the	the	DT
cord-299731-sis9952k	200	10	target	target	NN
cord-299731-sis9952k	200	11	SARS	SARS	NNP
cord-299731-sis9952k	200	12	-	-	HYPH
cord-299731-sis9952k	200	13	CoV-2	CoV-2	NNP
cord-299731-sis9952k	200	14	proteins	protein	NNS
cord-299731-sis9952k	200	15	[	[	-LRB-
cord-299731-sis9952k	200	16	126	126	CD
cord-299731-sis9952k	200	17	,	,	,
cord-299731-sis9952k	200	18	127	127	CD
cord-299731-sis9952k	200	19	]	]	-RRB-
cord-299731-sis9952k	200	20	.	.	.
cord-299731-sis9952k	201	1	PARPs	PARPs	NNP
cord-299731-sis9952k	201	2	response	response	NN
cord-299731-sis9952k	201	3	is	be	VBZ
cord-299731-sis9952k	201	4	required	require	VBN
cord-299731-sis9952k	201	5	for	for	IN
cord-299731-sis9952k	201	6	inhibition	inhibition	NN
cord-299731-sis9952k	201	7	of	of	IN
cord-299731-sis9952k	201	8	viral	viral	JJ
cord-299731-sis9952k	201	9	replication	replication	NN
cord-299731-sis9952k	201	10	[	[	-LRB-
cord-299731-sis9952k	201	11	128	128	CD
cord-299731-sis9952k	201	12	]	]	-RRB-
cord-299731-sis9952k	201	13	;	;	:
cord-299731-sis9952k	201	14	however	however	RB
cord-299731-sis9952k	201	15	,	,	,
cord-299731-sis9952k	201	16	this	this	DT
cord-299731-sis9952k	201	17	antiviral	antiviral	JJ
cord-299731-sis9952k	201	18	effect	effect	NN
cord-299731-sis9952k	201	19	is	be	VBZ
cord-299731-sis9952k	201	20	reversed	reverse	VBN
cord-299731-sis9952k	201	21	by	by	IN
cord-299731-sis9952k	201	22	the	the	DT
cord-299731-sis9952k	201	23	ADP	ADP	NNP
cord-299731-sis9952k	201	24	-	-	HYPH
cord-299731-sis9952k	201	25	ribosylhydrolase	ribosylhydrolase	NNP
cord-299731-sis9952k	201	26	macrodomain	macrodomain	NN
cord-299731-sis9952k	201	27	of	of	IN
cord-299731-sis9952k	201	28	the	the	DT
cord-299731-sis9952k	201	29	viral	viral	JJ
cord-299731-sis9952k	201	30	nonstructural	nonstructural	JJ
cord-299731-sis9952k	201	31	protein	protein	NN
cord-299731-sis9952k	201	32	,	,	,
cord-299731-sis9952k	201	33	nsp3	nsp3	NNS
cord-299731-sis9952k	201	34	,	,	,
cord-299731-sis9952k	201	35	whose	whose	WP$
cord-299731-sis9952k	201	36	activity	activity	NN
cord-299731-sis9952k	201	37	is	be	VBZ
cord-299731-sis9952k	201	38	required	require	VBN
cord-299731-sis9952k	201	39	for	for	IN
cord-299731-sis9952k	201	40	virulence	virulence	NN
cord-299731-sis9952k	201	41	[	[	-LRB-
cord-299731-sis9952k	201	42	126	126	CD
cord-299731-sis9952k	201	43	,	,	,
cord-299731-sis9952k	201	44	127	127	CD
cord-299731-sis9952k	201	45	,	,	,
cord-299731-sis9952k	201	46	129	129	CD
cord-299731-sis9952k	201	47	]	]	-RRB-
cord-299731-sis9952k	201	48	.	.	.
cord-299731-sis9952k	202	1	In	in	IN
cord-299731-sis9952k	202	2	addition	addition	NN
cord-299731-sis9952k	202	3	,	,	,
cord-299731-sis9952k	202	4	nsp10	nsp10	NNP
cord-299731-sis9952k	202	5	of	of	IN
cord-299731-sis9952k	202	6	SARS	SARS	NNP
cord-299731-sis9952k	202	7	-	-	HYPH
cord-299731-sis9952k	202	8	CoV	CoV	NNP
cord-299731-sis9952k	202	9	was	be	VBD
cord-299731-sis9952k	202	10	found	find	VBN
cord-299731-sis9952k	202	11	to	to	TO
cord-299731-sis9952k	202	12	inhibit	inhibit	VB
cord-299731-sis9952k	202	13	electron	electron	NN
cord-299731-sis9952k	202	14	transport	transport	NN
cord-299731-sis9952k	202	15	at	at	IN
cord-299731-sis9952k	202	16	the	the	DT
cord-299731-sis9952k	202	17	NADH	NADH	NNP
cord-299731-sis9952k	202	18	site	site	NN
cord-299731-sis9952k	202	19	of	of	IN
cord-299731-sis9952k	202	20	complex	complex	JJ
cord-299731-sis9952k	202	21	I	-PRON-	PRP
cord-299731-sis9952k	202	22	in	in	IN
cord-299731-sis9952k	202	23	the	the	DT
cord-299731-sis9952k	202	24	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	202	25	electron	electron	NN
cord-299731-sis9952k	202	26	transport	transport	NN
cord-299731-sis9952k	202	27	chain	chain	NN
cord-299731-sis9952k	202	28	[	[	-LRB-
cord-299731-sis9952k	202	29	130	130	CD
cord-299731-sis9952k	202	30	]	]	-RRB-
cord-299731-sis9952k	202	31	,	,	,
cord-299731-sis9952k	202	32	suggesting	suggest	VBG
cord-299731-sis9952k	202	33	that	that	IN
cord-299731-sis9952k	202	34	key	key	JJ
cord-299731-sis9952k	202	35	events	event	NNS
cord-299731-sis9952k	202	36	in	in	IN
cord-299731-sis9952k	202	37	the	the	DT
cord-299731-sis9952k	202	38	innate	innate	JJ
cord-299731-sis9952k	202	39	immune	immune	JJ
cord-299731-sis9952k	202	40	response	response	NN
cord-299731-sis9952k	202	41	to	to	IN
cord-299731-sis9952k	202	42	viral	viral	JJ
cord-299731-sis9952k	202	43	infections	infection	NNS
cord-299731-sis9952k	202	44	are	be	VBP
cord-299731-sis9952k	202	45	occurring	occur	VBG
cord-299731-sis9952k	202	46	within	within	IN
cord-299731-sis9952k	202	47	the	the	DT
cord-299731-sis9952k	202	48	infected	infected	JJ
cord-299731-sis9952k	202	49	cell	cell	NN
cord-299731-sis9952k	202	50	's	's	POS
cord-299731-sis9952k	202	51	NAD	NAD	NNP
cord-299731-sis9952k	202	52	+	+	CC
cord-299731-sis9952k	202	53	metabolome	metabolome	NNP
cord-299731-sis9952k	202	54	[	[	-LRB-
cord-299731-sis9952k	202	55	131	131	CD
cord-299731-sis9952k	202	56	]	]	-RRB-
cord-299731-sis9952k	202	57	.	.	.
cord-299731-sis9952k	203	1	Recent	recent	JJ
cord-299731-sis9952k	203	2	study	study	NN
cord-299731-sis9952k	203	3	investigated	investigate	VBD
cord-299731-sis9952k	203	4	PARPs	PARPs	JJR
cord-299731-sis9952k	203	5	expression	expression	NN
cord-299731-sis9952k	203	6	and	and	CC
cord-299731-sis9952k	203	7	NAD	NAD	NNP
cord-299731-sis9952k	203	8	+	+	CC
cord-299731-sis9952k	203	9	metabolome	metabolome	NNP
cord-299731-sis9952k	203	10	dysregulation	dysregulation	NN
cord-299731-sis9952k	203	11	due	due	IN
cord-299731-sis9952k	203	12	to	to	IN
cord-299731-sis9952k	203	13	coronavirus	coronavirus	NN
cord-299731-sis9952k	203	14	infection	infection	NN
cord-299731-sis9952k	203	15	.	.	.
cord-299731-sis9952k	204	1	The	the	DT
cord-299731-sis9952k	204	2	examined	examine	VBN
cord-299731-sis9952k	204	3	SARS	SARS	NNP
cord-299731-sis9952k	204	4	-	-	HYPH
cord-299731-sis9952k	204	5	CoV-2	CoV-2	NNP
cord-299731-sis9952k	204	6	infected	infected	JJ
cord-299731-sis9952k	204	7	cell	cell	NN
cord-299731-sis9952k	204	8	lines	line	NNS
cord-299731-sis9952k	204	9	of	of	IN
cord-299731-sis9952k	204	10	a	a	DT
cord-299731-sis9952k	204	11	ferret	ferret	NN
cord-299731-sis9952k	204	12	and	and	CC
cord-299731-sis9952k	204	13	deceased	deceased	JJ
cord-299731-sis9952k	204	14	patients	patient	NNS
cord-299731-sis9952k	204	15	'	'	POS
cord-299731-sis9952k	204	16	lungs	lung	NNS
cord-299731-sis9952k	204	17	showed	show	VBD
cord-299731-sis9952k	204	18	disturbed	disturb	VBN
cord-299731-sis9952k	204	19	NAD	NAD	NNP
cord-299731-sis9952k	204	20	+	+	CC
cord-299731-sis9952k	204	21	metabolism	metabolism	NN
cord-299731-sis9952k	204	22	and	and	CC
cord-299731-sis9952k	204	23	gene	gene	NN
cord-299731-sis9952k	204	24	expression	expression	NN
cord-299731-sis9952k	204	25	with	with	IN
cord-299731-sis9952k	204	26	respect	respect	NN
cord-299731-sis9952k	204	27	to	to	IN
cord-299731-sis9952k	204	28	synthesis	synthesis	NN
cord-299731-sis9952k	204	29	and	and	CC
cord-299731-sis9952k	204	30	utilization	utilization	NN
cord-299731-sis9952k	204	31	of	of	IN
cord-299731-sis9952k	204	32	NAD	NAD	NNP
cord-299731-sis9952k	204	33	+	+	CC
cord-299731-sis9952k	204	34	[	[	-LRB-
cord-299731-sis9952k	204	35	131	131	CD
cord-299731-sis9952k	204	36	]	]	-RRB-
cord-299731-sis9952k	204	37	.	.	.
cord-299731-sis9952k	205	1	Furthermore	furthermore	RB
cord-299731-sis9952k	205	2	,	,	,
cord-299731-sis9952k	205	3	the	the	DT
cord-299731-sis9952k	205	4	expression	expression	NN
cord-299731-sis9952k	205	5	of	of	IN
cord-299731-sis9952k	205	6	the	the	DT
cord-299731-sis9952k	205	7	NMRK1	NMRK1	NNP
cord-299731-sis9952k	205	8	pathway	pathway	NN
cord-299731-sis9952k	205	9	was	be	VBD
cord-299731-sis9952k	205	10	upregulated	upregulate	VBN
cord-299731-sis9952k	205	11	together	together	RB
cord-299731-sis9952k	205	12	with	with	IN
cord-299731-sis9952k	205	13	the	the	DT
cord-299731-sis9952k	205	14	expression	expression	NN
cord-299731-sis9952k	205	15	of	of	IN
cord-299731-sis9952k	205	16	the	the	DT
cord-299731-sis9952k	205	17	concentrative	concentrative	JJ
cord-299731-sis9952k	205	18	nucleoside	nucleoside	NN
cord-299731-sis9952k	205	19	transporter	transporter	NN
cord-299731-sis9952k	205	20	CNT3	CNT3	NNP
cord-299731-sis9952k	205	21	,	,	,
cord-299731-sis9952k	205	22	indicating	indicate	VBG
cord-299731-sis9952k	205	23	a	a	DT
cord-299731-sis9952k	205	24	higher	high	JJR
cord-299731-sis9952k	205	25	capacity	capacity	NN
cord-299731-sis9952k	205	26	for	for	IN
cord-299731-sis9952k	205	27	NR	nr	NN
cord-299731-sis9952k	205	28	conversion	conversion	NN
cord-299731-sis9952k	205	29	to	to	IN
cord-299731-sis9952k	205	30	NAD	NAD	NNP
cord-299731-sis9952k	205	31	+	+	CC
cord-299731-sis9952k	205	32	and	and	CC
cord-299731-sis9952k	205	33	NADP	NADP	NNP
cord-299731-sis9952k	206	1	+	+	CC
cord-299731-sis9952k	206	2	during	during	IN
cord-299731-sis9952k	206	3	the	the	DT
cord-299731-sis9952k	206	4	infection	infection	NN
cord-299731-sis9952k	206	5	[	[	-LRB-
cord-299731-sis9952k	206	6	10	10	CD
cord-299731-sis9952k	206	7	]	]	-RRB-
cord-299731-sis9952k	206	8	.	.	.
cord-299731-sis9952k	207	1	An	an	DT
cord-299731-sis9952k	207	2	upregulation	upregulation	NN
cord-299731-sis9952k	207	3	of	of	IN
cord-299731-sis9952k	207	4	the	the	DT
cord-299731-sis9952k	207	5	NMRK	NMRK	NNP
cord-299731-sis9952k	207	6	gene	gene	NN
cord-299731-sis9952k	207	7	was	be	VBD
cord-299731-sis9952k	207	8	previously	previously	RB
cord-299731-sis9952k	207	9	associated	associate	VBN
cord-299731-sis9952k	207	10	with	with	IN
cord-299731-sis9952k	207	11	therapeutic	therapeutic	JJ
cord-299731-sis9952k	207	12	efficacy	efficacy	NN
cord-299731-sis9952k	207	13	of	of	IN
cord-299731-sis9952k	207	14	NR	NR	NNP
cord-299731-sis9952k	207	15	[	[	-LRB-
cord-299731-sis9952k	207	16	66	66	CD
cord-299731-sis9952k	207	17	,	,	,
cord-299731-sis9952k	207	18	105	105	CD
cord-299731-sis9952k	207	19	]	]	-RRB-
cord-299731-sis9952k	207	20	.	.	.
cord-299731-sis9952k	208	1	In	in	IN
cord-299731-sis9952k	208	2	addition	addition	NN
cord-299731-sis9952k	208	3	,	,	,
cord-299731-sis9952k	208	4	the	the	DT
cord-299731-sis9952k	208	5	expression	expression	NN
cord-299731-sis9952k	208	6	of	of	IN
cord-299731-sis9952k	208	7	NNMT	NNMT	NNP
cord-299731-sis9952k	208	8	(	(	-LRB-
cord-299731-sis9952k	208	9	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	208	10	N	n	NN
cord-299731-sis9952k	208	11	-	-	HYPH
cord-299731-sis9952k	208	12	methyltransferase	methyltransferase	NNP
cord-299731-sis9952k	208	13	)	)	-RRB-
cord-299731-sis9952k	208	14	was	be	VBD
cord-299731-sis9952k	208	15	decreased	decrease	VBN
cord-299731-sis9952k	208	16	[	[	-LRB-
cord-299731-sis9952k	208	17	131	131	CD
cord-299731-sis9952k	208	18	]	]	-RRB-
cord-299731-sis9952k	208	19	due	due	IN
cord-299731-sis9952k	208	20	to	to	TO
cord-299731-sis9952k	208	21	lower	lower	VB
cord-299731-sis9952k	208	22	NAM	NAM	NNP
cord-299731-sis9952k	208	23	methylation	methylation	NN
cord-299731-sis9952k	208	24	,	,	,
cord-299731-sis9952k	208	25	suggesting	suggest	VBG
cord-299731-sis9952k	208	26	a	a	DT
cord-299731-sis9952k	208	27	promotion	promotion	NN
cord-299731-sis9952k	208	28	of	of	IN
cord-299731-sis9952k	208	29	the	the	DT
cord-299731-sis9952k	208	30	NAM	NAM	NNP
cord-299731-sis9952k	208	31	salvage	salvage	NN
cord-299731-sis9952k	208	32	pathway	pathway	NN
cord-299731-sis9952k	208	33	[	[	-LRB-
cord-299731-sis9952k	208	34	132	132	CD
cord-299731-sis9952k	208	35	]	]	-RRB-
cord-299731-sis9952k	208	36	and	and	CC
cord-299731-sis9952k	208	37	increased	increase	VBN
cord-299731-sis9952k	208	38	efficiency	efficiency	NN
cord-299731-sis9952k	208	39	of	of	IN
cord-299731-sis9952k	208	40	NR	NR	NNP
cord-299731-sis9952k	208	41	treatment	treatment	NN
cord-299731-sis9952k	208	42	to	to	TO
cord-299731-sis9952k	208	43	replenish	replenish	VB
cord-299731-sis9952k	208	44	NAD	NAD	NNP
cord-299731-sis9952k	208	45	+	+	CC
cord-299731-sis9952k	208	46	[	[	-LRB-
cord-299731-sis9952k	208	47	131	131	CD
cord-299731-sis9952k	208	48	]	]	-RRB-
cord-299731-sis9952k	208	49	.	.	.
cord-299731-sis9952k	209	1	These	these	DT
cord-299731-sis9952k	209	2	data	datum	NNS
cord-299731-sis9952k	209	3	indicate	indicate	VBP
cord-299731-sis9952k	209	4	that	that	IN
cord-299731-sis9952k	209	5	boosting	boost	VBG
cord-299731-sis9952k	209	6	NAD	NAD	NNP
cord-299731-sis9952k	209	7	+	+	CC
cord-299731-sis9952k	209	8	content	content	NN
cord-299731-sis9952k	209	9	through	through	IN
cord-299731-sis9952k	209	10	NAM	NAM	NNP
cord-299731-sis9952k	209	11	and	and	CC
cord-299731-sis9952k	209	12	NR	NR	NNP
cord-299731-sis9952k	209	13	kinase	kinase	NN
cord-299731-sis9952k	209	14	pathways	pathway	NNS
cord-299731-sis9952k	209	15	may	may	MD
cord-299731-sis9952k	209	16	restore	restore	VB
cord-299731-sis9952k	209	17	antiviral	antiviral	JJ
cord-299731-sis9952k	209	18	PARPs	parp	NNS
cord-299731-sis9952k	209	19	functions	function	NNS
cord-299731-sis9952k	209	20	to	to	TO
cord-299731-sis9952k	209	21	support	support	VB
cord-299731-sis9952k	209	22	innate	innate	JJ
cord-299731-sis9952k	209	23	immunity	immunity	NN
cord-299731-sis9952k	209	24	to	to	IN
cord-299731-sis9952k	209	25	SARS	SARS	NNP
cord-299731-sis9952k	209	26	-	-	HYPH
cord-299731-sis9952k	209	27	CoV-2	CoV-2	NNP
cord-299731-sis9952k	209	28	[	[	-LRB-
cord-299731-sis9952k	209	29	131	131	CD
cord-299731-sis9952k	209	30	]	]	-RRB-
cord-299731-sis9952k	209	31	.	.	.
cord-299731-sis9952k	210	1	Upon	upon	IN
cord-299731-sis9952k	210	2	activation	activation	NN
cord-299731-sis9952k	210	3	of	of	IN
cord-299731-sis9952k	210	4	the	the	DT
cord-299731-sis9952k	210	5	adaptive	adaptive	JJ
cord-299731-sis9952k	210	6	immune	immune	JJ
cord-299731-sis9952k	210	7	response	response	NN
cord-299731-sis9952k	210	8	,	,	,
cord-299731-sis9952k	210	9	the	the	DT
cord-299731-sis9952k	210	10	overexpression	overexpression	NN
cord-299731-sis9952k	210	11	of	of	IN
cord-299731-sis9952k	210	12	CD38	CD38	NNP
cord-299731-sis9952k	210	13	in	in	IN
cord-299731-sis9952k	210	14	both	both	DT
cord-299731-sis9952k	210	15	CD4	CD4	NNP
cord-299731-sis9952k	210	16	+	+	CC
cord-299731-sis9952k	210	17	and	and	CC
cord-299731-sis9952k	210	18	CD8	CD8	NNP
cord-299731-sis9952k	210	19	+	+	CC
cord-299731-sis9952k	210	20	lymphocytes	lymphocytes	NN
cord-299731-sis9952k	210	21	further	further	RB
cord-299731-sis9952k	210	22	exaggerates	exaggerate	VBZ
cord-299731-sis9952k	210	23	NAD	NAD	NNP
cord-299731-sis9952k	210	24	+	+	CC
cord-299731-sis9952k	210	25	depletion	depletion	NN
cord-299731-sis9952k	210	26	[	[	-LRB-
cord-299731-sis9952k	210	27	133	133	CD
cord-299731-sis9952k	210	28	,	,	,
cord-299731-sis9952k	210	29	134	134	CD
cord-299731-sis9952k	210	30	]	]	-RRB-
cord-299731-sis9952k	210	31	leading	lead	VBG
cord-299731-sis9952k	210	32	to	to	IN
cord-299731-sis9952k	210	33	increased	increase	VBN
cord-299731-sis9952k	210	34	production	production	NN
cord-299731-sis9952k	210	35	and	and	CC
cord-299731-sis9952k	210	36	release	release	NN
cord-299731-sis9952k	210	37	of	of	IN
cord-299731-sis9952k	210	38	proinflammatory	proinflammatory	JJ
cord-299731-sis9952k	210	39	cytokines	cytokine	NNS
cord-299731-sis9952k	210	40	,	,	,
cord-299731-sis9952k	210	41	reactive	reactive	JJ
cord-299731-sis9952k	210	42	oxygen	oxygen	NN
cord-299731-sis9952k	210	43	species	specie	NNS
cord-299731-sis9952k	210	44	,	,	,
cord-299731-sis9952k	210	45	and	and	CC
cord-299731-sis9952k	210	46	macrophage	macrophage	NN
cord-299731-sis9952k	210	47	infiltration	infiltration	NN
cord-299731-sis9952k	210	48	[	[	-LRB-
cord-299731-sis9952k	210	49	135	135	CD
cord-299731-sis9952k	210	50	,	,	,
cord-299731-sis9952k	210	51	136	136	CD
cord-299731-sis9952k	210	52	]	]	-RRB-
cord-299731-sis9952k	210	53	.	.	.
cord-299731-sis9952k	211	1	Furthermore	furthermore	RB
cord-299731-sis9952k	211	2	,	,	,
cord-299731-sis9952k	211	3	drastic	drastic	JJ
cord-299731-sis9952k	211	4	NAD	NAD	NNP
cord-299731-sis9952k	211	5	+	+	CC
cord-299731-sis9952k	211	6	depletion	depletion	NN
cord-299731-sis9952k	211	7	impairs	impair	VBZ
cord-299731-sis9952k	211	8	the	the	DT
cord-299731-sis9952k	211	9	function	function	NN
cord-299731-sis9952k	211	10	of	of	IN
cord-299731-sis9952k	211	11	sirtuins	sirtuin	NNS
cord-299731-sis9952k	211	12	,	,	,
cord-299731-sis9952k	211	13	the	the	DT
cord-299731-sis9952k	211	14	regulators	regulator	NNS
cord-299731-sis9952k	211	15	of	of	IN
cord-299731-sis9952k	211	16	cell	cell	NN
cord-299731-sis9952k	211	17	death	death	NN
cord-299731-sis9952k	211	18	and	and	CC
cord-299731-sis9952k	211	19	viability	viability	NN
cord-299731-sis9952k	211	20	[	[	-LRB-
cord-299731-sis9952k	211	21	133	133	CD
cord-299731-sis9952k	211	22	]	]	-RRB-
cord-299731-sis9952k	211	23	.	.	.
cord-299731-sis9952k	212	1	Specifically	specifically	RB
cord-299731-sis9952k	212	2	,	,	,
cord-299731-sis9952k	212	3	SIRT1	SIRT1	NNP
cord-299731-sis9952k	212	4	regulates	regulate	VBZ
cord-299731-sis9952k	212	5	the	the	DT
cord-299731-sis9952k	212	6	expression	expression	NN
cord-299731-sis9952k	212	7	of	of	IN
cord-299731-sis9952k	212	8	genes	gene	NNS
cord-299731-sis9952k	212	9	including	include	VBG
cord-299731-sis9952k	212	10	tumor	tumor	NN
cord-299731-sis9952k	212	11	suppressors	suppressor	NNS
cord-299731-sis9952k	212	12	,	,	,
cord-299731-sis9952k	212	13	cytokines	cytokine	NNS
cord-299731-sis9952k	212	14	and	and	CC
cord-299731-sis9952k	212	15	proto	proto	NN
cord-299731-sis9952k	212	16	-	-	HYPH
cord-299731-sis9952k	212	17	oncogenes	oncogene	NNS
cord-299731-sis9952k	212	18	and	and	CC
cord-299731-sis9952k	212	19	ultimately	ultimately	RB
cord-299731-sis9952k	212	20	modulates	modulate	VBZ
cord-299731-sis9952k	212	21	inflammation	inflammation	NN
cord-299731-sis9952k	212	22	,	,	,
cord-299731-sis9952k	212	23	cell	cell	NN
cord-299731-sis9952k	212	24	survival	survival	NN
cord-299731-sis9952k	212	25	,	,	,
cord-299731-sis9952k	212	26	and	and	CC
cord-299731-sis9952k	212	27	apoptosis	apoptosis	NN
cord-299731-sis9952k	212	28	mechanisms	mechanism	NNS
cord-299731-sis9952k	212	29	[	[	-LRB-
cord-299731-sis9952k	212	30	137	137	CD
cord-299731-sis9952k	212	31	]	]	-RRB-
cord-299731-sis9952k	212	32	.	.	.
cord-299731-sis9952k	213	1	Loss	loss	NN
cord-299731-sis9952k	213	2	of	of	IN
cord-299731-sis9952k	213	3	sirtuin	sirtuin	NN
cord-299731-sis9952k	213	4	function	function	NN
cord-299731-sis9952k	213	5	along	along	IN
cord-299731-sis9952k	213	6	with	with	IN
cord-299731-sis9952k	213	7	increased	increase	VBN
cord-299731-sis9952k	213	8	oxidative	oxidative	JJ
cord-299731-sis9952k	213	9	damage	damage	NN
cord-299731-sis9952k	213	10	and	and	CC
cord-299731-sis9952k	213	11	an	an	DT
cord-299731-sis9952k	213	12	overall	overall	JJ
cord-299731-sis9952k	213	13	energy	energy	NN
cord-299731-sis9952k	213	14	decrease	decrease	NN
cord-299731-sis9952k	213	15	finally	finally	RB
cord-299731-sis9952k	213	16	culminates	culminate	VBZ
cord-299731-sis9952k	213	17	in	in	IN
cord-299731-sis9952k	213	18	cell	cell	NN
cord-299731-sis9952k	213	19	death	death	NN
cord-299731-sis9952k	213	20	.	.	.
cord-299731-sis9952k	214	1	Replenishment	replenishment	NN
cord-299731-sis9952k	214	2	of	of	IN
cord-299731-sis9952k	214	3	NAD	NAD	NNP
cord-299731-sis9952k	214	4	+	+	CC
cord-299731-sis9952k	214	5	body	body	NN
cord-299731-sis9952k	214	6	content	content	NN
cord-299731-sis9952k	214	7	could	could	MD
cord-299731-sis9952k	214	8	restore	restore	VB
cord-299731-sis9952k	214	9	energy	energy	NN
cord-299731-sis9952k	214	10	levels	level	NNS
cord-299731-sis9952k	214	11	and	and	CC
cord-299731-sis9952k	214	12	impaired	impair	VBN
cord-299731-sis9952k	214	13	sirtuin	sirtuin	NNP
cord-299731-sis9952k	214	14	function	function	NN
cord-299731-sis9952k	214	15	and	and	CC
cord-299731-sis9952k	214	16	possibly	possibly	RB
cord-299731-sis9952k	214	17	rebalance	rebalance	VB
cord-299731-sis9952k	214	18	the	the	DT
cord-299731-sis9952k	214	19	maladaptive	maladaptive	JJ
cord-299731-sis9952k	214	20	immune	immune	JJ
cord-299731-sis9952k	214	21	response	response	NN
cord-299731-sis9952k	214	22	to	to	IN
cord-299731-sis9952k	214	23	SARS	SARS	NNP
cord-299731-sis9952k	214	24	-	-	HYPH
cord-299731-sis9952k	214	25	CoV-2	CoV-2	NNP
cord-299731-sis9952k	214	26	infection	infection	NN
cord-299731-sis9952k	214	27	.	.	.
cord-299731-sis9952k	215	1	Namely	namely	RB
cord-299731-sis9952k	215	2	,	,	,
cord-299731-sis9952k	215	3	both	both	DT
cord-299731-sis9952k	215	4	SARS	SARS	NNP
cord-299731-sis9952k	215	5	-	-	HYPH
cord-299731-sis9952k	215	6	CoV	CoV	NNP
cord-299731-sis9952k	215	7	and	and	CC
cord-299731-sis9952k	215	8	SARS	SARS	NNP
cord-299731-sis9952k	215	9	-	-	HYPH
cord-299731-sis9952k	215	10	CoV-2	CoV-2	NNP
cord-299731-sis9952k	215	11	induce	induce	VB
cord-299731-sis9952k	215	12	maladaptive	maladaptive	JJ
cord-299731-sis9952k	215	13	hyperinflammation	hyperinflammation	NN
cord-299731-sis9952k	215	14	followed	follow	VBN
cord-299731-sis9952k	215	15	by	by	IN
cord-299731-sis9952k	215	16	increased	increase	VBN
cord-299731-sis9952k	215	17	leucocyte	leucocyte	JJ
cord-299731-sis9952k	215	18	infiltration	infiltration	NN
cord-299731-sis9952k	215	19	into	into	IN
cord-299731-sis9952k	215	20	the	the	DT
cord-299731-sis9952k	215	21	lungs	lung	NNS
cord-299731-sis9952k	215	22	resulting	result	VBG
cord-299731-sis9952k	215	23	in	in	IN
cord-299731-sis9952k	215	24	extensive	extensive	JJ
cord-299731-sis9952k	215	25	tissue	tissue	NN
cord-299731-sis9952k	215	26	damage	damage	NN
cord-299731-sis9952k	215	27	and	and	CC
cord-299731-sis9952k	215	28	subsequent	subsequent	JJ
cord-299731-sis9952k	215	29	organ	organ	NN
cord-299731-sis9952k	215	30	failure	failure	NN
cord-299731-sis9952k	215	31	with	with	IN
cord-299731-sis9952k	215	32	reduced	reduce	VBN
cord-299731-sis9952k	215	33	lung	lung	NN
cord-299731-sis9952k	215	34	capacity	capacity	NN
cord-299731-sis9952k	215	35	[	[	-LRB-
cord-299731-sis9952k	215	36	138	138	CD
cord-299731-sis9952k	215	37	]	]	-RRB-
cord-299731-sis9952k	215	38	[	[	-LRB-
cord-299731-sis9952k	215	39	139	139	CD
cord-299731-sis9952k	215	40	]	]	-RRB-
cord-299731-sis9952k	215	41	[	[	-LRB-
cord-299731-sis9952k	215	42	140	140	CD
cord-299731-sis9952k	215	43	]	]	-RRB-
cord-299731-sis9952k	215	44	.	.	.
cord-299731-sis9952k	216	1	Emerging	emerge	VBG
cord-299731-sis9952k	216	2	evidence	evidence	NN
cord-299731-sis9952k	216	3	has	have	VBZ
cord-299731-sis9952k	216	4	demonstrated	demonstrate	VBN
cord-299731-sis9952k	216	5	that	that	IN
cord-299731-sis9952k	216	6	NAD	NAD	NNP
cord-299731-sis9952k	216	7	+	+	CC
cord-299731-sis9952k	216	8	is	be	VBZ
cord-299731-sis9952k	216	9	released	release	VBN
cord-299731-sis9952k	216	10	during	during	IN
cord-299731-sis9952k	216	11	the	the	DT
cord-299731-sis9952k	216	12	early	early	JJ
cord-299731-sis9952k	216	13	phase	phase	NN
cord-299731-sis9952k	216	14	of	of	IN
cord-299731-sis9952k	216	15	inflammation	inflammation	NN
cord-299731-sis9952k	216	16	and	and	CC
cord-299731-sis9952k	216	17	has	have	VBZ
cord-299731-sis9952k	216	18	an	an	DT
cord-299731-sis9952k	216	19	immunoregulatory	immunoregulatory	JJ
cord-299731-sis9952k	216	20	role	role	NN
cord-299731-sis9952k	216	21	in	in	IN
cord-299731-sis9952k	216	22	vivo	vivo	NNP
cord-299731-sis9952k	216	23	[	[	-LRB-
cord-299731-sis9952k	216	24	141	141	CD
cord-299731-sis9952k	216	25	,	,	,
cord-299731-sis9952k	216	26	142	142	CD
cord-299731-sis9952k	216	27	]	]	-RRB-
cord-299731-sis9952k	216	28	.	.	.
cord-299731-sis9952k	217	1	Moreover	moreover	RB
cord-299731-sis9952k	217	2	,	,	,
cord-299731-sis9952k	217	3	niacin	niacin	NN
cord-299731-sis9952k	217	4	was	be	VBD
cord-299731-sis9952k	217	5	previously	previously	RB
cord-299731-sis9952k	217	6	suggested	suggest	VBN
cord-299731-sis9952k	217	7	as	as	IN
cord-299731-sis9952k	217	8	an	an	DT
cord-299731-sis9952k	217	9	anti	anti	JJ
cord-299731-sis9952k	217	10	-	-	JJ
cord-299731-sis9952k	217	11	inflammatory	inflammatory	JJ
cord-299731-sis9952k	217	12	therapy	therapy	NN
cord-299731-sis9952k	217	13	in	in	IN
cord-299731-sis9952k	217	14	one	one	CD
cord-299731-sis9952k	217	15	preclinical	preclinical	JJ
cord-299731-sis9952k	217	16	study	study	NN
cord-299731-sis9952k	217	17	as	as	IN
cord-299731-sis9952k	217	18	a	a	DT
cord-299731-sis9952k	217	19	potent	potent	JJ
cord-299731-sis9952k	217	20	agent	agent	NN
cord-299731-sis9952k	217	21	to	to	TO
cord-299731-sis9952k	217	22	decrease	decrease	VB
cord-299731-sis9952k	217	23	proinflammatory	proinflammatory	JJ
cord-299731-sis9952k	217	24	cytokines	cytokine	NNS
cord-299731-sis9952k	217	25	,	,	,
cord-299731-sis9952k	217	26	including	include	VBG
cord-299731-sis9952k	217	27	IL-1	IL-1	NNP
cord-299731-sis9952k	217	28	,	,	,
cord-299731-sis9952k	217	29	IL-6	IL-6	NNP
cord-299731-sis9952k	217	30	,	,	,
cord-299731-sis9952k	217	31	and	and	CC
cord-299731-sis9952k	217	32	TNFα	TNFα	NNS
cord-299731-sis9952k	217	33	[	[	-LRB-
cord-299731-sis9952k	217	34	143	143	CD
cord-299731-sis9952k	217	35	]	]	-RRB-
cord-299731-sis9952k	217	36	.	.	.
cord-299731-sis9952k	218	1	NR	NR	NNP
cord-299731-sis9952k	218	2	can	can	MD
cord-299731-sis9952k	218	3	similarly	similarly	RB
cord-299731-sis9952k	218	4	decrease	decrease	VB
cord-299731-sis9952k	218	5	IL-2	il-2	NN
cord-299731-sis9952k	218	6	,	,	,
cord-299731-sis9952k	218	7	IL-5	IL-5	NNP
cord-299731-sis9952k	218	8	,	,	,
cord-299731-sis9952k	218	9	IL-6	IL-6	NNP
cord-299731-sis9952k	218	10	,	,	,
cord-299731-sis9952k	218	11	and	and	CC
cord-299731-sis9952k	218	12	TNFα	TNFα	NNS
cord-299731-sis9952k	218	13	[	[	-LRB-
cord-299731-sis9952k	218	14	120	120	CD
cord-299731-sis9952k	218	15	]	]	-RRB-
cord-299731-sis9952k	218	16	.	.	.
cord-299731-sis9952k	219	1	Targeting	Targeting	NNP
cord-299731-sis9952k	219	2	IL-6	IL-6	NNP
cord-299731-sis9952k	219	3	has	have	VBZ
cord-299731-sis9952k	219	4	been	be	VBN
cord-299731-sis9952k	219	5	recently	recently	RB
cord-299731-sis9952k	219	6	proposed	propose	VBN
cord-299731-sis9952k	219	7	as	as	IN
cord-299731-sis9952k	219	8	a	a	DT
cord-299731-sis9952k	219	9	promising	promising	JJ
cord-299731-sis9952k	219	10	treatment	treatment	NN
cord-299731-sis9952k	219	11	to	to	TO
cord-299731-sis9952k	219	12	block	block	VB
cord-299731-sis9952k	219	13	the	the	DT
cord-299731-sis9952k	219	14	inflammatory	inflammatory	JJ
cord-299731-sis9952k	219	15	storm	storm	NN
cord-299731-sis9952k	219	16	,	,	,
cord-299731-sis9952k	219	17	especially	especially	RB
cord-299731-sis9952k	219	18	in	in	IN
cord-299731-sis9952k	219	19	severe	severe	JJ
cord-299731-sis9952k	219	20	COVID-19	covid-19	JJ
cord-299731-sis9952k	219	21	patients	patient	NNS
cord-299731-sis9952k	219	22	[	[	-LRB-
cord-299731-sis9952k	219	23	132	132	CD
cord-299731-sis9952k	219	24	]	]	-RRB-
cord-299731-sis9952k	219	25	.	.	.
cord-299731-sis9952k	220	1	Furthermore	furthermore	RB
cord-299731-sis9952k	220	2	,	,	,
cord-299731-sis9952k	220	3	niacin	niacin	NN
cord-299731-sis9952k	220	4	might	may	MD
cord-299731-sis9952k	220	5	also	also	RB
cord-299731-sis9952k	220	6	decrease	decrease	VB
cord-299731-sis9952k	220	7	neutrophil	neutrophil	NN
cord-299731-sis9952k	220	8	infiltration	infiltration	NN
cord-299731-sis9952k	220	9	,	,	,
cord-299731-sis9952k	220	10	while	while	IN
cord-299731-sis9952k	220	11	exhibiting	exhibit	VBG
cord-299731-sis9952k	220	12	a	a	DT
cord-299731-sis9952k	220	13	prolonged	prolonged	JJ
cord-299731-sis9952k	220	14	anti	anti	JJ
cord-299731-sis9952k	220	15	-	-	JJ
cord-299731-sis9952k	220	16	inflammatory	inflammatory	JJ
cord-299731-sis9952k	220	17	effect	effect	NN
cord-299731-sis9952k	220	18	during	during	IN
cord-299731-sis9952k	220	19	ventilator	ventilator	NN
cord-299731-sis9952k	220	20	-	-	HYPH
cord-299731-sis9952k	220	21	induced	induce	VBN
cord-299731-sis9952k	220	22	lung	lung	NN
cord-299731-sis9952k	220	23	injury	injury	NN
cord-299731-sis9952k	220	24	.	.	.
cord-299731-sis9952k	221	1	However	however	RB
cord-299731-sis9952k	221	2	,	,	,
cord-299731-sis9952k	221	3	niacin	niacin	NN
cord-299731-sis9952k	221	4	exacerbated	exacerbate	VBD
cord-299731-sis9952k	221	5	hypoxemia	hypoxemia	NN
cord-299731-sis9952k	221	6	regardless	regardless	RB
cord-299731-sis9952k	221	7	of	of	IN
cord-299731-sis9952k	221	8	the	the	DT
cord-299731-sis9952k	221	9	neutrophil	neutrophil	NN
cord-299731-sis9952k	221	10	infiltration	infiltration	NN
cord-299731-sis9952k	221	11	decrease	decrease	NN
cord-299731-sis9952k	221	12	,	,	,
cord-299731-sis9952k	221	13	suggesting	suggest	VBG
cord-299731-sis9952k	221	14	a	a	DT
cord-299731-sis9952k	221	15	different	different	JJ
cord-299731-sis9952k	221	16	cause	cause	NN
cord-299731-sis9952k	221	17	of	of	IN
cord-299731-sis9952k	221	18	hypoxemia	hypoxemia	NN
cord-299731-sis9952k	221	19	,	,	,
cord-299731-sis9952k	221	20	independent	independent	JJ
cord-299731-sis9952k	221	21	of	of	IN
cord-299731-sis9952k	221	22	neutrophil	neutrophil	NN
cord-299731-sis9952k	221	23	decline	decline	NN
cord-299731-sis9952k	221	24	[	[	-LRB-
cord-299731-sis9952k	221	25	144	144	CD
cord-299731-sis9952k	221	26	,	,	,
cord-299731-sis9952k	221	27	145	145	CD
cord-299731-sis9952k	221	28	]	]	-RRB-
cord-299731-sis9952k	221	29	,	,	,
cord-299731-sis9952k	221	30	which	which	WDT
cord-299731-sis9952k	221	31	requires	require	VBZ
cord-299731-sis9952k	221	32	further	further	JJ
cord-299731-sis9952k	221	33	investigation	investigation	NN
cord-299731-sis9952k	221	34	.	.	.
cord-299731-sis9952k	222	1	In	in	IN
cord-299731-sis9952k	222	2	addition	addition	NN
cord-299731-sis9952k	222	3	,	,	,
cord-299731-sis9952k	222	4	high	high	JJ
cord-299731-sis9952k	222	5	efficiency	efficiency	NN
cord-299731-sis9952k	222	6	of	of	IN
cord-299731-sis9952k	222	7	vitamin	vitamin	NN
cord-299731-sis9952k	222	8	B3	b3	NN
cord-299731-sis9952k	222	9	(	(	-LRB-
cord-299731-sis9952k	222	10	niacin	niacin	NN
cord-299731-sis9952k	222	11	or	or	CC
cord-299731-sis9952k	222	12	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	222	13	)	)	-RRB-
cord-299731-sis9952k	222	14	in	in	IN
cord-299731-sis9952k	222	15	preventing	prevent	VBG
cord-299731-sis9952k	222	16	lung	lung	NN
cord-299731-sis9952k	222	17	tissue	tissue	NN
cord-299731-sis9952k	222	18	damage	damage	NN
cord-299731-sis9952k	222	19	was	be	VBD
cord-299731-sis9952k	222	20	confirmed	confirm	VBN
cord-299731-sis9952k	222	21	in	in	IN
cord-299731-sis9952k	222	22	several	several	JJ
cord-299731-sis9952k	222	23	animal	animal	NN
cord-299731-sis9952k	222	24	models	model	NNS
cord-299731-sis9952k	222	25	with	with	IN
cord-299731-sis9952k	222	26	bleomycin	bleomycin	NN
cord-299731-sis9952k	222	27	-	-	:
cord-299731-sis9952k	222	28	and	and	CC
cord-299731-sis9952k	222	29	LPS	LPS	NNP
cord-299731-sis9952k	222	30	-	-	HYPH
cord-299731-sis9952k	222	31	induced	induce	VBN
cord-299731-sis9952k	222	32	lung	lung	NN
cord-299731-sis9952k	222	33	injury	injury	NN
cord-299731-sis9952k	222	34	[	[	-LRB-
cord-299731-sis9952k	222	35	146	146	CD
cord-299731-sis9952k	222	36	]	]	-RRB-
cord-299731-sis9952k	222	37	[	[	-LRB-
cord-299731-sis9952k	222	38	147	147	CD
cord-299731-sis9952k	222	39	]	]	-RRB-
cord-299731-sis9952k	222	40	[	[	-LRB-
cord-299731-sis9952k	222	41	148	148	CD
cord-299731-sis9952k	222	42	]	]	-RRB-
cord-299731-sis9952k	222	43	.	.	.
cord-299731-sis9952k	223	1	Considering	consider	VBG
cord-299731-sis9952k	223	2	vitamin	vitamin	NN
cord-299731-sis9952k	223	3	B3	b3	NN
cord-299731-sis9952k	223	4	s	s	POS
cord-299731-sis9952k	223	5	strong	strong	JJ
cord-299731-sis9952k	223	6	lung	lung	NN
cord-299731-sis9952k	223	7	-	-	HYPH
cord-299731-sis9952k	223	8	protective	protective	JJ
cord-299731-sis9952k	223	9	effects	effect	NNS
cord-299731-sis9952k	223	10	,	,	,
cord-299731-sis9952k	223	11	it	-PRON-	PRP
cord-299731-sis9952k	223	12	has	have	VBZ
cord-299731-sis9952k	223	13	been	be	VBN
cord-299731-sis9952k	223	14	proposed	propose	VBN
cord-299731-sis9952k	223	15	as	as	IN
cord-299731-sis9952k	223	16	an	an	DT
cord-299731-sis9952k	223	17	early	early	JJ
cord-299731-sis9952k	223	18	treatment	treatment	NN
cord-299731-sis9952k	223	19	-	-	HYPH
cord-299731-sis9952k	223	20	supporting	support	VBG
cord-299731-sis9952k	223	21	agent	agent	NN
cord-299731-sis9952k	223	22	against	against	IN
cord-299731-sis9952k	223	23	COVID-19	COVID-19	NNP
cord-299731-sis9952k	223	24	[	[	-LRB-
cord-299731-sis9952k	223	25	146	146	CD
cord-299731-sis9952k	223	26	]	]	-RRB-
cord-299731-sis9952k	223	27	.	.	.
cord-299731-sis9952k	224	1	This	this	DT
cord-299731-sis9952k	224	2	implies	imply	VBZ
cord-299731-sis9952k	224	3	that	that	IN
cord-299731-sis9952k	224	4	NR	NR	NNP
cord-299731-sis9952k	224	5	should	should	MD
cord-299731-sis9952k	224	6	be	be	VB
cord-299731-sis9952k	224	7	considered	consider	VBN
cord-299731-sis9952k	224	8	as	as	IN
cord-299731-sis9952k	224	9	a	a	DT
cord-299731-sis9952k	224	10	potential	potential	JJ
cord-299731-sis9952k	224	11	therapeutic	therapeutic	JJ
cord-299731-sis9952k	224	12	or	or	CC
cord-299731-sis9952k	224	13	supporting	support	VBG
cord-299731-sis9952k	224	14	agent	agent	NN
cord-299731-sis9952k	224	15	to	to	TO
cord-299731-sis9952k	224	16	reduce	reduce	VB
cord-299731-sis9952k	224	17	hyperinflammation	hyperinflammation	NN
cord-299731-sis9952k	224	18	and	and	CC
cord-299731-sis9952k	224	19	regenerate	regenerate	VB
cord-299731-sis9952k	224	20	damaged	damaged	JJ
cord-299731-sis9952k	224	21	lung	lung	NN
cord-299731-sis9952k	224	22	tissue	tissue	NN
cord-299731-sis9952k	224	23	.	.	.
cord-299731-sis9952k	225	1	The	the	DT
cord-299731-sis9952k	225	2	bioavailability	bioavailability	NN
cord-299731-sis9952k	225	3	of	of	IN
cord-299731-sis9952k	225	4	NR	NR	NNP
cord-299731-sis9952k	225	5	can	can	MD
cord-299731-sis9952k	225	6	be	be	VB
cord-299731-sis9952k	225	7	tested	test	VBN
cord-299731-sis9952k	225	8	by	by	IN
cord-299731-sis9952k	225	9	measuring	measure	VBG
cord-299731-sis9952k	225	10	NAD	NAD	NNP
cord-299731-sis9952k	226	1	+	+	CC
cord-299731-sis9952k	226	2	levels	level	NNS
cord-299731-sis9952k	226	3	or	or	CC
cord-299731-sis9952k	226	4	other	other	JJ
cord-299731-sis9952k	226	5	relevant	relevant	JJ
cord-299731-sis9952k	226	6	biomarkers	biomarker	NNS
cord-299731-sis9952k	226	7	such	such	JJ
cord-299731-sis9952k	226	8	as	as	IN
cord-299731-sis9952k	226	9	nicotinic	nicotinic	JJ
cord-299731-sis9952k	226	10	acid	acid	NN
cord-299731-sis9952k	226	11	adenine	adenine	NN
cord-299731-sis9952k	226	12	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	226	13	(	(	-LRB-
cord-299731-sis9952k	226	14	NAAD	NAAD	NNP
cord-299731-sis9952k	226	15	)	)	-RRB-
cord-299731-sis9952k	226	16	in	in	IN
cord-299731-sis9952k	226	17	the	the	DT
cord-299731-sis9952k	226	18	cells	cell	NNS
cord-299731-sis9952k	226	19	of	of	IN
cord-299731-sis9952k	226	20	the	the	DT
cord-299731-sis9952k	226	21	target	target	NN
cord-299731-sis9952k	226	22	tissue	tissue	NN
cord-299731-sis9952k	226	23	or	or	CC
cord-299731-sis9952k	226	24	in	in	IN
cord-299731-sis9952k	226	25	the	the	DT
cord-299731-sis9952k	226	26	blood	blood	NN
cord-299731-sis9952k	226	27	.	.	.
cord-299731-sis9952k	227	1	Throughout	throughout	IN
cord-299731-sis9952k	227	2	numerous	numerous	JJ
cord-299731-sis9952k	227	3	observations	observation	NNS
cord-299731-sis9952k	227	4	in	in	IN
cord-299731-sis9952k	227	5	a	a	DT
cord-299731-sis9952k	227	6	wide	wide	JJ
cord-299731-sis9952k	227	7	variety	variety	NN
cord-299731-sis9952k	227	8	of	of	IN
cord-299731-sis9952k	227	9	mammalian	mammalian	JJ
cord-299731-sis9952k	227	10	cell	cell	NN
cord-299731-sis9952k	227	11	lines	line	NNS
cord-299731-sis9952k	227	12	including	include	VBG
cord-299731-sis9952k	227	13	liver	liver	NN
cord-299731-sis9952k	227	14	,	,	,
cord-299731-sis9952k	227	15	skeletal	skeletal	JJ
cord-299731-sis9952k	227	16	muscles	muscle	NNS
cord-299731-sis9952k	227	17	,	,	,
cord-299731-sis9952k	227	18	and	and	CC
cord-299731-sis9952k	227	19	brown	brown	JJ
cord-299731-sis9952k	227	20	adipose	adipose	JJ
cord-299731-sis9952k	227	21	tissue	tissue	NN
cord-299731-sis9952k	227	22	,	,	,
cord-299731-sis9952k	227	23	NR	NR	NNP
cord-299731-sis9952k	227	24	was	be	VBD
cord-299731-sis9952k	227	25	documented	document	VBN
cord-299731-sis9952k	227	26	to	to	TO
cord-299731-sis9952k	227	27	enhance	enhance	VB
cord-299731-sis9952k	227	28	NAD	NAD	NNP
cord-299731-sis9952k	228	1	+	+	CC
cord-299731-sis9952k	228	2	levels	level	NNS
cord-299731-sis9952k	228	3	[	[	-LRB-
cord-299731-sis9952k	228	4	37	37	CD
cord-299731-sis9952k	228	5	]	]	-RRB-
cord-299731-sis9952k	228	6	.	.	.
cord-299731-sis9952k	229	1	Conversely	conversely	RB
cord-299731-sis9952k	229	2	,	,	,
cord-299731-sis9952k	229	3	the	the	DT
cord-299731-sis9952k	229	4	NAD	NAD	NNP
cord-299731-sis9952k	229	5	+	+	CC
cord-299731-sis9952k	229	6	levels	level	NNS
cord-299731-sis9952k	229	7	did	do	VBD
cord-299731-sis9952k	229	8	not	not	RB
cord-299731-sis9952k	229	9	significantly	significantly	RB
cord-299731-sis9952k	229	10	increase	increase	VB
cord-299731-sis9952k	229	11	in	in	IN
cord-299731-sis9952k	229	12	the	the	DT
cord-299731-sis9952k	229	13	brain	brain	NN
cord-299731-sis9952k	229	14	or	or	CC
cord-299731-sis9952k	229	15	white	white	JJ
cord-299731-sis9952k	229	16	adipose	adipose	JJ
cord-299731-sis9952k	229	17	tissue	tissue	NN
cord-299731-sis9952k	229	18	[	[	-LRB-
cord-299731-sis9952k	229	19	37	37	CD
cord-299731-sis9952k	229	20	]	]	-RRB-
cord-299731-sis9952k	229	21	.	.	.
cord-299731-sis9952k	230	1	It	-PRON-	PRP
cord-299731-sis9952k	230	2	was	be	VBD
cord-299731-sis9952k	230	3	suggested	suggest	VBN
cord-299731-sis9952k	230	4	that	that	IN
cord-299731-sis9952k	230	5	the	the	DT
cord-299731-sis9952k	230	6	observed	observed	JJ
cord-299731-sis9952k	230	7	differences	difference	NNS
cord-299731-sis9952k	230	8	are	be	VBP
cord-299731-sis9952k	230	9	caused	cause	VBN
cord-299731-sis9952k	230	10	due	due	IN
cord-299731-sis9952k	230	11	to	to	IN
cord-299731-sis9952k	230	12	differential	differential	JJ
cord-299731-sis9952k	230	13	Nmrk	Nmrk	NNP
cord-299731-sis9952k	230	14	expression	expression	NN
cord-299731-sis9952k	230	15	in	in	IN
cord-299731-sis9952k	230	16	the	the	DT
cord-299731-sis9952k	230	17	specific	specific	JJ
cord-299731-sis9952k	230	18	tissues	tissue	NNS
cord-299731-sis9952k	230	19	.	.	.
cord-299731-sis9952k	231	1	While	while	IN
cord-299731-sis9952k	231	2	Nmrk1	Nmrk1	NNP
cord-299731-sis9952k	231	3	is	be	VBZ
cord-299731-sis9952k	231	4	expressed	express	VBN
cord-299731-sis9952k	231	5	ubiquitously	ubiquitously	RB
cord-299731-sis9952k	231	6	,	,	,
cord-299731-sis9952k	231	7	Nmrk2	Nmrk2	NNP
cord-299731-sis9952k	231	8	is	be	VBZ
cord-299731-sis9952k	231	9	mainly	mainly	RB
cord-299731-sis9952k	231	10	expressed	express	VBN
cord-299731-sis9952k	231	11	in	in	IN
cord-299731-sis9952k	231	12	cardiac	cardiac	JJ
cord-299731-sis9952k	231	13	and	and	CC
cord-299731-sis9952k	231	14	skeletal	skeletal	JJ
cord-299731-sis9952k	231	15	muscles	muscle	NNS
cord-299731-sis9952k	231	16	,	,	,
cord-299731-sis9952k	231	17	but	but	CC
cord-299731-sis9952k	231	18	also	also	RB
cord-299731-sis9952k	231	19	detectable	detectable	JJ
cord-299731-sis9952k	231	20	in	in	IN
cord-299731-sis9952k	231	21	the	the	DT
cord-299731-sis9952k	231	22	liver	liver	NN
cord-299731-sis9952k	231	23	and	and	CC
cord-299731-sis9952k	231	24	brown	brown	JJ
cord-299731-sis9952k	231	25	adipose	adipose	JJ
cord-299731-sis9952k	231	26	tissue	tissue	NN
cord-299731-sis9952k	231	27	which	which	WDT
cord-299731-sis9952k	231	28	might	may	MD
cord-299731-sis9952k	231	29	explain	explain	VB
cord-299731-sis9952k	231	30	the	the	DT
cord-299731-sis9952k	231	31	better	well	JJR
cord-299731-sis9952k	231	32	ability	ability	NN
cord-299731-sis9952k	231	33	of	of	IN
cord-299731-sis9952k	231	34	these	these	DT
cord-299731-sis9952k	231	35	tissues	tissue	NNS
cord-299731-sis9952k	231	36	to	to	TO
cord-299731-sis9952k	231	37	respond	respond	VB
cord-299731-sis9952k	231	38	to	to	IN
cord-299731-sis9952k	231	39	NR	NR	NNP
cord-299731-sis9952k	231	40	.	.	.
cord-299731-sis9952k	232	1	On	on	IN
cord-299731-sis9952k	232	2	the	the	DT
cord-299731-sis9952k	232	3	other	other	JJ
cord-299731-sis9952k	232	4	hand	hand	NN
cord-299731-sis9952k	232	5	,	,	,
cord-299731-sis9952k	232	6	NR	NR	NNP
cord-299731-sis9952k	232	7	is	be	VBZ
cord-299731-sis9952k	232	8	very	very	RB
cord-299731-sis9952k	232	9	unstable	unstable	JJ
cord-299731-sis9952k	232	10	in	in	IN
cord-299731-sis9952k	232	11	the	the	DT
cord-299731-sis9952k	232	12	blood	blood	NN
cord-299731-sis9952k	232	13	,	,	,
cord-299731-sis9952k	232	14	which	which	WDT
cord-299731-sis9952k	232	15	makes	make	VBZ
cord-299731-sis9952k	232	16	it	-PRON-	PRP
cord-299731-sis9952k	232	17	difficult	difficult	JJ
cord-299731-sis9952k	232	18	to	to	TO
cord-299731-sis9952k	232	19	measure	measure	VB
cord-299731-sis9952k	232	20	and	and	CC
cord-299731-sis9952k	232	21	detect	detect	VB
cord-299731-sis9952k	232	22	.	.	.
cord-299731-sis9952k	233	1	Despite	despite	IN
cord-299731-sis9952k	233	2	its	-PRON-	PRP$
cord-299731-sis9952k	233	3	instability	instability	NN
cord-299731-sis9952k	233	4	,	,	,
cord-299731-sis9952k	233	5	the	the	DT
cord-299731-sis9952k	233	6	development	development	NN
cord-299731-sis9952k	233	7	of	of	IN
cord-299731-sis9952k	233	8	reliable	reliable	JJ
cord-299731-sis9952k	233	9	methods	method	NNS
cord-299731-sis9952k	233	10	for	for	IN
cord-299731-sis9952k	233	11	collection	collection	NN
cord-299731-sis9952k	233	12	,	,	,
cord-299731-sis9952k	233	13	processing	processing	NN
cord-299731-sis9952k	233	14	,	,	,
cord-299731-sis9952k	233	15	and	and	CC
cord-299731-sis9952k	233	16	measuring	measuring	NN
cord-299731-sis9952k	233	17	has	have	VBZ
cord-299731-sis9952k	233	18	enabled	enable	VBN
cord-299731-sis9952k	233	19	the	the	DT
cord-299731-sis9952k	233	20	determination	determination	NN
cord-299731-sis9952k	233	21	of	of	IN
cord-299731-sis9952k	233	22	the	the	DT
cord-299731-sis9952k	233	23	pharmacokinetic	pharmacokinetic	JJ
cord-299731-sis9952k	233	24	profile	profile	NN
cord-299731-sis9952k	233	25	of	of	IN
cord-299731-sis9952k	233	26	orally	orally	RB
cord-299731-sis9952k	233	27	administered	administer	VBN
cord-299731-sis9952k	233	28	NR	NR	NNP
cord-299731-sis9952k	233	29	.	.	.
cord-299731-sis9952k	234	1	The	the	DT
cord-299731-sis9952k	234	2	study	study	NN
cord-299731-sis9952k	234	3	conducted	conduct	VBN
cord-299731-sis9952k	234	4	in	in	IN
cord-299731-sis9952k	234	5	both	both	DT
cord-299731-sis9952k	234	6	healthy	healthy	JJ
cord-299731-sis9952k	234	7	human	human	JJ
cord-299731-sis9952k	234	8	volunteers	volunteer	NNS
cord-299731-sis9952k	234	9	and	and	CC
cord-299731-sis9952k	234	10	mice	mouse	NNS
cord-299731-sis9952k	234	11	reported	report	VBD
cord-299731-sis9952k	234	12	that	that	IN
cord-299731-sis9952k	234	13	an	an	DT
cord-299731-sis9952k	234	14	NR	NR	NNP
cord-299731-sis9952k	234	15	dose	dose	NN
cord-299731-sis9952k	234	16	of	of	IN
cord-299731-sis9952k	234	17	1000	1000	CD
cord-299731-sis9952k	234	18	mg	mg	NNS
cord-299731-sis9952k	234	19	twice	twice	RB
cord-299731-sis9952k	234	20	daily	daily	JJ
cord-299731-sis9952k	234	21	(	(	-LRB-
cord-299731-sis9952k	234	22	2000	2000	CD
cord-299731-sis9952k	234	23	mg	mg	NN
cord-299731-sis9952k	234	24	in	in	IN
cord-299731-sis9952k	234	25	total	total	NN
cord-299731-sis9952k	234	26	)	)	-RRB-
cord-299731-sis9952k	234	27	can	can	MD
cord-299731-sis9952k	234	28	significantly	significantly	RB
cord-299731-sis9952k	234	29	increase	increase	VB
cord-299731-sis9952k	234	30	steady	steady	JJ
cord-299731-sis9952k	234	31	-	-	HYPH
cord-299731-sis9952k	234	32	state	state	NN
cord-299731-sis9952k	234	33	,	,	,
cord-299731-sis9952k	234	34	whole	whole	JJ
cord-299731-sis9952k	234	35	-	-	HYPH
cord-299731-sis9952k	234	36	blood	blood	NN
cord-299731-sis9952k	234	37	levels	level	NNS
cord-299731-sis9952k	234	38	of	of	IN
cord-299731-sis9952k	234	39	NAD	NAD	NNP
cord-299731-sis9952k	234	40	+	+	CC
cord-299731-sis9952k	234	41	(	(	-LRB-
cord-299731-sis9952k	234	42	up	up	IN
cord-299731-sis9952k	234	43	to	to	TO
cord-299731-sis9952k	234	44	2.7	2.7	CD
cord-299731-sis9952k	234	45	fold	fold	VB
cord-299731-sis9952k	234	46	after	after	IN
cord-299731-sis9952k	234	47	one	one	CD
cord-299731-sis9952k	234	48	dose	dose	NN
cord-299731-sis9952k	234	49	)	)	-RRB-
cord-299731-sis9952k	234	50	[	[	-LRB-
cord-299731-sis9952k	234	51	149	149	CD
cord-299731-sis9952k	234	52	]	]	-RRB-
cord-299731-sis9952k	234	53	and	and	CC
cord-299731-sis9952k	234	54	effectively	effectively	RB
cord-299731-sis9952k	234	55	stimulate	stimulate	VB
cord-299731-sis9952k	234	56	NAD	NAD	NNP
cord-299731-sis9952k	234	57	+	+	CC
cord-299731-sis9952k	234	58	metabolism	metabolism	NN
cord-299731-sis9952k	234	59	[	[	-LRB-
cord-299731-sis9952k	234	60	39	39	CD
cord-299731-sis9952k	234	61	,	,	,
cord-299731-sis9952k	234	62	149	149	CD
cord-299731-sis9952k	234	63	,	,	,
cord-299731-sis9952k	234	64	150	150	CD
cord-299731-sis9952k	234	65	]	]	-RRB-
cord-299731-sis9952k	234	66	.	.	.
cord-299731-sis9952k	235	1	The	the	DT
cord-299731-sis9952k	235	2	studies	study	NNS
cord-299731-sis9952k	235	3	also	also	RB
cord-299731-sis9952k	235	4	confirmed	confirm	VBD
cord-299731-sis9952k	235	5	that	that	IN
cord-299731-sis9952k	235	6	measurable	measurable	JJ
cord-299731-sis9952k	235	7	,	,	,
cord-299731-sis9952k	235	8	biological	biological	JJ
cord-299731-sis9952k	235	9	effects	effect	NNS
cord-299731-sis9952k	235	10	on	on	IN
cord-299731-sis9952k	235	11	NAD	NAD	NNP
cord-299731-sis9952k	235	12	+	+	CC
cord-299731-sis9952k	235	13	levels	level	NNS
cord-299731-sis9952k	235	14	can	can	MD
cord-299731-sis9952k	235	15	be	be	VB
cord-299731-sis9952k	235	16	achieved	achieve	VBN
cord-299731-sis9952k	235	17	by	by	IN
cord-299731-sis9952k	235	18	chronic	chronic	JJ
cord-299731-sis9952k	235	19	oral	oral	JJ
cord-299731-sis9952k	235	20	NR	NR	NNP
cord-299731-sis9952k	235	21	supplementation	supplementation	NN
cord-299731-sis9952k	235	22	with	with	IN
cord-299731-sis9952k	235	23	no	no	DT
cord-299731-sis9952k	235	24	serious	serious	JJ
cord-299731-sis9952k	235	25	adverse	adverse	JJ
cord-299731-sis9952k	235	26	effects	effect	NNS
cord-299731-sis9952k	235	27	[	[	-LRB-
cord-299731-sis9952k	235	28	39	39	CD
cord-299731-sis9952k	235	29	,	,	,
cord-299731-sis9952k	235	30	150	150	CD
cord-299731-sis9952k	235	31	]	]	-RRB-
cord-299731-sis9952k	235	32	.	.	.
cord-299731-sis9952k	236	1	Specifically	specifically	RB
cord-299731-sis9952k	236	2	,	,	,
cord-299731-sis9952k	236	3	there	there	EX
cord-299731-sis9952k	236	4	were	be	VBD
cord-299731-sis9952k	236	5	no	no	DT
cord-299731-sis9952k	236	6	severe	severe	JJ
cord-299731-sis9952k	236	7	side	side	NN
cord-299731-sis9952k	236	8	effects	effect	NNS
cord-299731-sis9952k	236	9	reported	report	VBD
cord-299731-sis9952k	236	10	such	such	JJ
cord-299731-sis9952k	236	11	as	as	IN
cord-299731-sis9952k	236	12	flushing	flushing	NN
cord-299731-sis9952k	236	13	,	,	,
cord-299731-sis9952k	236	14	pruritus	pruritus	NN
cord-299731-sis9952k	236	15	,	,	,
cord-299731-sis9952k	236	16	hyperglycemia	hyperglycemia	NN
cord-299731-sis9952k	236	17	,	,	,
cord-299731-sis9952k	236	18	hyperuricemia	hyperuricemia	NN
cord-299731-sis9952k	236	19	,	,	,
cord-299731-sis9952k	236	20	or	or	CC
cord-299731-sis9952k	236	21	increased	increase	VBN
cord-299731-sis9952k	236	22	enzyme	enzyme	NN
cord-299731-sis9952k	236	23	activity	activity	NN
cord-299731-sis9952k	236	24	in	in	IN
cord-299731-sis9952k	236	25	the	the	DT
cord-299731-sis9952k	236	26	liver	liver	NN
cord-299731-sis9952k	236	27	or	or	CC
cord-299731-sis9952k	236	28	muscle	muscle	NN
cord-299731-sis9952k	236	29	[	[	-LRB-
cord-299731-sis9952k	236	30	149	149	CD
cord-299731-sis9952k	236	31	]	]	-RRB-
cord-299731-sis9952k	236	32	[	[	-LRB-
cord-299731-sis9952k	236	33	150	150	CD
cord-299731-sis9952k	236	34	]	]	-RRB-
cord-299731-sis9952k	236	35	[	[	-LRB-
cord-299731-sis9952k	236	36	151	151	CD
cord-299731-sis9952k	236	37	]	]	-RRB-
cord-299731-sis9952k	236	38	[	[	-LRB-
cord-299731-sis9952k	236	39	152	152	CD
cord-299731-sis9952k	236	40	]	]	-RRB-
cord-299731-sis9952k	236	41	.	.	.
cord-299731-sis9952k	237	1	However	however	RB
cord-299731-sis9952k	237	2	,	,	,
cord-299731-sis9952k	237	3	the	the	DT
cord-299731-sis9952k	237	4	blood	blood	NN
cord-299731-sis9952k	237	5	NAD	NAD	NNP
cord-299731-sis9952k	238	1	+	+	CC
cord-299731-sis9952k	238	2	response	response	NN
cord-299731-sis9952k	238	3	did	do	VBD
cord-299731-sis9952k	238	4	not	not	RB
cord-299731-sis9952k	238	5	appear	appear	VB
cord-299731-sis9952k	238	6	to	to	TO
cord-299731-sis9952k	238	7	correlate	correlate	VB
cord-299731-sis9952k	238	8	with	with	IN
cord-299731-sis9952k	238	9	the	the	DT
cord-299731-sis9952k	238	10	absorption	absorption	NN
cord-299731-sis9952k	238	11	pattern	pattern	NN
cord-299731-sis9952k	238	12	of	of	IN
cord-299731-sis9952k	238	13	NR	nr	NN
cord-299731-sis9952k	238	14	and	and	CC
cord-299731-sis9952k	238	15	the	the	DT
cord-299731-sis9952k	238	16	peak	peak	NN
cord-299731-sis9952k	238	17	in	in	IN
cord-299731-sis9952k	238	18	NAD	NAD	NNP
cord-299731-sis9952k	239	1	+	+	CC
cord-299731-sis9952k	240	1	increase	increase	NN
cord-299731-sis9952k	240	2	was	be	VBD
cord-299731-sis9952k	240	3	reached	reach	VBN
cord-299731-sis9952k	240	4	after	after	IN
cord-299731-sis9952k	240	5	9	9	CD
cord-299731-sis9952k	240	6	days	day	NNS
cord-299731-sis9952k	240	7	[	[	-LRB-
cord-299731-sis9952k	240	8	150	150	CD
cord-299731-sis9952k	240	9	]	]	-RRB-
cord-299731-sis9952k	240	10	.	.	.
cord-299731-sis9952k	241	1	Furthermore	furthermore	RB
cord-299731-sis9952k	241	2	,	,	,
cord-299731-sis9952k	241	3	it	-PRON-	PRP
cord-299731-sis9952k	241	4	was	be	VBD
cord-299731-sis9952k	241	5	suggested	suggest	VBN
cord-299731-sis9952k	241	6	that	that	IN
cord-299731-sis9952k	241	7	repeated	repeat	VBN
cord-299731-sis9952k	241	8	dosing	dosing	NN
cord-299731-sis9952k	241	9	would	would	MD
cord-299731-sis9952k	241	10	be	be	VB
cord-299731-sis9952k	241	11	required	require	VBN
cord-299731-sis9952k	241	12	to	to	TO
cord-299731-sis9952k	241	13	prevent	prevent	VB
cord-299731-sis9952k	241	14	wide	wide	JJ
cord-299731-sis9952k	241	15	fluctuations	fluctuation	NNS
cord-299731-sis9952k	241	16	in	in	IN
cord-299731-sis9952k	241	17	body	body	NN
cord-299731-sis9952k	241	18	levels	level	NNS
cord-299731-sis9952k	241	19	of	of	IN
cord-299731-sis9952k	241	20	NR	nr	NN
cord-299731-sis9952k	241	21	due	due	IN
cord-299731-sis9952k	241	22	to	to	IN
cord-299731-sis9952k	241	23	a	a	DT
cord-299731-sis9952k	241	24	relatively	relatively	RB
cord-299731-sis9952k	241	25	short	short	JJ
cord-299731-sis9952k	241	26	elimination	elimination	NN
cord-299731-sis9952k	241	27	half	half	JJ
cord-299731-sis9952k	241	28	-	-	HYPH
cord-299731-sis9952k	241	29	life	life	NN
cord-299731-sis9952k	241	30	of	of	IN
cord-299731-sis9952k	241	31	NR	NR	NNP
cord-299731-sis9952k	241	32	observed	observe	VBN
cord-299731-sis9952k	241	33	in	in	IN
cord-299731-sis9952k	241	34	several	several	JJ
cord-299731-sis9952k	241	35	subjects	subject	NNS
cord-299731-sis9952k	241	36	;	;	:
cord-299731-sis9952k	241	37	however	however	RB
cord-299731-sis9952k	241	38	,	,	,
cord-299731-sis9952k	241	39	continuous	continuous	JJ
cord-299731-sis9952k	241	40	blood	blood	NN
cord-299731-sis9952k	241	41	levels	level	NNS
cord-299731-sis9952k	241	42	of	of	IN
cord-299731-sis9952k	241	43	NAD	NAD	NNP
cord-299731-sis9952k	241	44	+	+	CC
cord-299731-sis9952k	241	45	suggest	suggest	VBP
cord-299731-sis9952k	241	46	that	that	IN
cord-299731-sis9952k	241	47	twice	twice	RB
cord-299731-sis9952k	241	48	-	-	HYPH
cord-299731-sis9952k	241	49	daily	daily	NN
cord-299731-sis9952k	241	50	or	or	CC
cord-299731-sis9952k	241	51	even	even	RB
cord-299731-sis9952k	241	52	once	once	RB
cord-299731-sis9952k	241	53	-	-	HYPH
cord-299731-sis9952k	241	54	daily	daily	RB
cord-299731-sis9952k	241	55	dosing	dosing	NN
cord-299731-sis9952k	241	56	of	of	IN
cord-299731-sis9952k	241	57	NR	NR	NNP
cord-299731-sis9952k	241	58	may	may	MD
cord-299731-sis9952k	241	59	be	be	VB
cord-299731-sis9952k	241	60	sufficient	sufficient	JJ
cord-299731-sis9952k	241	61	to	to	TO
cord-299731-sis9952k	241	62	achieve	achieve	VB
cord-299731-sis9952k	241	63	a	a	DT
cord-299731-sis9952k	241	64	desired	desire	VBN
cord-299731-sis9952k	241	65	clinical	clinical	JJ
cord-299731-sis9952k	241	66	outcome	outcome	NN
cord-299731-sis9952k	241	67	[	[	-LRB-
cord-299731-sis9952k	241	68	150	150	CD
cord-299731-sis9952k	241	69	]	]	-RRB-
cord-299731-sis9952k	241	70	.	.	.
cord-299731-sis9952k	242	1	On	on	IN
cord-299731-sis9952k	242	2	the	the	DT
cord-299731-sis9952k	242	3	other	other	JJ
cord-299731-sis9952k	242	4	hand	hand	NN
cord-299731-sis9952k	242	5	,	,	,
cord-299731-sis9952k	242	6	the	the	DT
cord-299731-sis9952k	242	7	apparent	apparent	JJ
cord-299731-sis9952k	242	8	oral	oral	JJ
cord-299731-sis9952k	242	9	bioavailability	bioavailability	NN
cord-299731-sis9952k	242	10	of	of	IN
cord-299731-sis9952k	242	11	a	a	DT
cord-299731-sis9952k	242	12	1000	1000	CD
cord-299731-sis9952k	242	13	mg	mg	NN
cord-299731-sis9952k	242	14	dose	dose	NN
cord-299731-sis9952k	242	15	of	of	IN
cord-299731-sis9952k	242	16	NR	NR	NNP
cord-299731-sis9952k	242	17	was	be	VBD
cord-299731-sis9952k	242	18	highly	highly	RB
cord-299731-sis9952k	242	19	variable	variable	JJ
cord-299731-sis9952k	242	20	among	among	IN
cord-299731-sis9952k	242	21	individuals	individual	NNS
cord-299731-sis9952k	242	22	[	[	-LRB-
cord-299731-sis9952k	242	23	150	150	CD
cord-299731-sis9952k	242	24	]	]	-RRB-
cord-299731-sis9952k	242	25	.	.	.
cord-299731-sis9952k	243	1	The	the	DT
cord-299731-sis9952k	243	2	instability	instability	NN
cord-299731-sis9952k	243	3	of	of	IN
cord-299731-sis9952k	243	4	NR	nr	NN
cord-299731-sis9952k	243	5	in	in	IN
cord-299731-sis9952k	243	6	blood	blood	NN
cord-299731-sis9952k	243	7	samples	sample	NNS
cord-299731-sis9952k	243	8	observed	observe	VBN
cord-299731-sis9952k	243	9	across	across	IN
cord-299731-sis9952k	243	10	several	several	JJ
cord-299731-sis9952k	243	11	studies	study	NNS
cord-299731-sis9952k	243	12	[	[	-LRB-
cord-299731-sis9952k	243	13	150	150	CD
cord-299731-sis9952k	243	14	,	,	,
cord-299731-sis9952k	243	15	153	153	CD
cord-299731-sis9952k	243	16	]	]	-RRB-
cord-299731-sis9952k	243	17	could	could	MD
cord-299731-sis9952k	243	18	be	be	VB
cord-299731-sis9952k	243	19	one	one	CD
cord-299731-sis9952k	243	20	contributing	contribute	VBG
cord-299731-sis9952k	243	21	factor	factor	NN
cord-299731-sis9952k	243	22	,	,	,
cord-299731-sis9952k	243	23	although	although	IN
cord-299731-sis9952k	243	24	it	-PRON-	PRP
cord-299731-sis9952k	243	25	can	can	MD
cord-299731-sis9952k	243	26	not	not	RB
cord-299731-sis9952k	243	27	completely	completely	RB
cord-299731-sis9952k	243	28	explain	explain	VB
cord-299731-sis9952k	243	29	the	the	DT
cord-299731-sis9952k	243	30	observed	observed	JJ
cord-299731-sis9952k	243	31	variability	variability	NN
cord-299731-sis9952k	243	32	.	.	.
cord-299731-sis9952k	244	1	Another	another	DT
cord-299731-sis9952k	244	2	proposed	propose	VBN
cord-299731-sis9952k	244	3	explanation	explanation	NN
cord-299731-sis9952k	244	4	was	be	VBD
cord-299731-sis9952k	244	5	the	the	DT
cord-299731-sis9952k	244	6	NR	NR	NNP
cord-299731-sis9952k	244	7	hydrophilicity	hydrophilicity	NN
cord-299731-sis9952k	244	8	[	[	-LRB-
cord-299731-sis9952k	244	9	15	15	CD
cord-299731-sis9952k	244	10	]	]	-RRB-
cord-299731-sis9952k	244	11	since	since	IN
cord-299731-sis9952k	244	12	NR	NR	NNP
cord-299731-sis9952k	244	13	is	be	VBZ
cord-299731-sis9952k	244	14	expected	expect	VBN
cord-299731-sis9952k	244	15	to	to	TO
cord-299731-sis9952k	244	16	exhibit	exhibit	VB
cord-299731-sis9952k	244	17	low	low	JJ
cord-299731-sis9952k	244	18	passive	passive	JJ
cord-299731-sis9952k	244	19	permeability	permeability	NN
cord-299731-sis9952k	244	20	across	across	IN
cord-299731-sis9952k	244	21	the	the	DT
cord-299731-sis9952k	244	22	human	human	JJ
cord-299731-sis9952k	244	23	intestinal	intestinal	JJ
cord-299731-sis9952k	244	24	mucosa	mucosa	.
cord-299731-sis9952k	244	25	[	[	-LRB-
cord-299731-sis9952k	244	26	150	150	CD
cord-299731-sis9952k	244	27	]	]	-RRB-
cord-299731-sis9952k	244	28	.	.	.
cord-299731-sis9952k	245	1	Additionally	additionally	RB
cord-299731-sis9952k	245	2	,	,	,
cord-299731-sis9952k	245	3	the	the	DT
cord-299731-sis9952k	245	4	interindividual	interindividual	JJ
cord-299731-sis9952k	245	5	variation	variation	NN
cord-299731-sis9952k	245	6	in	in	IN
cord-299731-sis9952k	245	7	the	the	DT
cord-299731-sis9952k	245	8	transport	transport	NN
cord-299731-sis9952k	245	9	mechanism	mechanism	NN
cord-299731-sis9952k	245	10	of	of	IN
cord-299731-sis9952k	245	11	NR	nr	NN
cord-299731-sis9952k	245	12	in	in	IN
cord-299731-sis9952k	245	13	the	the	DT
cord-299731-sis9952k	245	14	intestinal	intestinal	JJ
cord-299731-sis9952k	245	15	system	system	NN
cord-299731-sis9952k	245	16	might	may	MD
cord-299731-sis9952k	245	17	also	also	RB
cord-299731-sis9952k	245	18	affect	affect	VB
cord-299731-sis9952k	245	19	the	the	DT
cord-299731-sis9952k	245	20	oral	oral	JJ
cord-299731-sis9952k	245	21	absorption	absorption	NN
cord-299731-sis9952k	245	22	of	of	IN
cord-299731-sis9952k	245	23	NR	NR	NNP
cord-299731-sis9952k	245	24	.	.	.
cord-299731-sis9952k	246	1	Furthermore	furthermore	RB
cord-299731-sis9952k	246	2	,	,	,
cord-299731-sis9952k	246	3	it	-PRON-	PRP
cord-299731-sis9952k	246	4	was	be	VBD
cord-299731-sis9952k	246	5	proposed	propose	VBN
cord-299731-sis9952k	246	6	that	that	IN
cord-299731-sis9952k	246	7	NR	NR	NNP
cord-299731-sis9952k	246	8	can	can	MD
cord-299731-sis9952k	246	9	be	be	VB
cord-299731-sis9952k	246	10	degraded	degrade	VBN
cord-299731-sis9952k	246	11	to	to	IN
cord-299731-sis9952k	246	12	NAM	NAM	NNP
cord-299731-sis9952k	246	13	in	in	IN
cord-299731-sis9952k	246	14	the	the	DT
cord-299731-sis9952k	246	15	gut	gut	NN
cord-299731-sis9952k	246	16	,	,	,
cord-299731-sis9952k	246	17	whereas	whereas	RB
cord-299731-sis9952k	246	18	,	,	,
cord-299731-sis9952k	246	19	another	another	DT
cord-299731-sis9952k	246	20	study	study	NN
cord-299731-sis9952k	246	21	showed	show	VBD
cord-299731-sis9952k	246	22	that	that	IN
cord-299731-sis9952k	246	23	NR	NR	NNP
cord-299731-sis9952k	246	24	is	be	VBZ
cord-299731-sis9952k	246	25	metabolized	metabolize	VBN
cord-299731-sis9952k	246	26	to	to	IN
cord-299731-sis9952k	246	27	NAM	NAM	NNP
cord-299731-sis9952k	246	28	in	in	IN
cord-299731-sis9952k	246	29	the	the	DT
cord-299731-sis9952k	246	30	liver	liver	NN
cord-299731-sis9952k	246	31	and	and	CC
cord-299731-sis9952k	246	32	might	may	MD
cord-299731-sis9952k	246	33	explain	explain	VB
cord-299731-sis9952k	246	34	low	low	JJ
cord-299731-sis9952k	246	35	bioavailability	bioavailability	NN
cord-299731-sis9952k	246	36	in	in	IN
cord-299731-sis9952k	246	37	other	other	JJ
cord-299731-sis9952k	246	38	tissues	tissue	NNS
cord-299731-sis9952k	246	39	[	[	-LRB-
cord-299731-sis9952k	246	40	154	154	CD
cord-299731-sis9952k	246	41	]	]	-RRB-
cord-299731-sis9952k	246	42	.	.	.
cord-299731-sis9952k	247	1	Subsequently	subsequently	RB
cord-299731-sis9952k	247	2	,	,	,
cord-299731-sis9952k	247	3	NAM	NAM	NNP
cord-299731-sis9952k	247	4	can	can	MD
cord-299731-sis9952k	247	5	be	be	VB
cord-299731-sis9952k	247	6	absorbed	absorb	VBN
cord-299731-sis9952k	247	7	and	and	CC
cord-299731-sis9952k	247	8	converted	convert	VBN
cord-299731-sis9952k	247	9	to	to	IN
cord-299731-sis9952k	247	10	NMN	NMN	NNP
cord-299731-sis9952k	247	11	,	,	,
cord-299731-sis9952k	247	12	and	and	CC
cord-299731-sis9952k	247	13	further	further	RB
cord-299731-sis9952k	247	14	metabolized	metabolize	VBN
cord-299731-sis9952k	247	15	to	to	IN
cord-299731-sis9952k	247	16	NAD	NAD	NNP
cord-299731-sis9952k	247	17	+	+	CC
cord-299731-sis9952k	247	18	or	or	CC
cord-299731-sis9952k	247	19	dephosphorylated	dephosphorylate	VBN
cord-299731-sis9952k	247	20	to	to	IN
cord-299731-sis9952k	247	21	NR	NR	NNP
cord-299731-sis9952k	247	22	.	.	.
cord-299731-sis9952k	248	1	In	in	IN
cord-299731-sis9952k	248	2	this	this	DT
cord-299731-sis9952k	248	3	case	case	NN
cord-299731-sis9952k	248	4	,	,	,
cord-299731-sis9952k	248	5	the	the	DT
cord-299731-sis9952k	248	6	degradation	degradation	NN
cord-299731-sis9952k	248	7	of	of	IN
cord-299731-sis9952k	248	8	NR	NR	NNP
cord-299731-sis9952k	248	9	to	to	IN
cord-299731-sis9952k	248	10	NAM	NAM	NNP
cord-299731-sis9952k	248	11	in	in	IN
cord-299731-sis9952k	248	12	the	the	DT
cord-299731-sis9952k	248	13	gut	gut	NN
cord-299731-sis9952k	248	14	,	,	,
cord-299731-sis9952k	248	15	which	which	WDT
cord-299731-sis9952k	248	16	presumably	presumably	RB
cord-299731-sis9952k	248	17	involves	involve	VBZ
cord-299731-sis9952k	248	18	purine	purine	NN
cord-299731-sis9952k	248	19	nucleoside	nucleoside	NN
cord-299731-sis9952k	248	20	phosphorylase	phosphorylase	NN
cord-299731-sis9952k	248	21	in	in	IN
cord-299731-sis9952k	248	22	mammalian	mammalian	JJ
cord-299731-sis9952k	248	23	and	and	CC
cord-299731-sis9952k	248	24	bacterial	bacterial	JJ
cord-299731-sis9952k	248	25	cells	cell	NNS
cord-299731-sis9952k	248	26	,	,	,
cord-299731-sis9952k	248	27	may	may	MD
cord-299731-sis9952k	248	28	be	be	VB
cord-299731-sis9952k	248	29	the	the	DT
cord-299731-sis9952k	248	30	variable	variable	JJ
cord-299731-sis9952k	248	31	step	step	NN
cord-299731-sis9952k	248	32	involved	involve	VBN
cord-299731-sis9952k	248	33	in	in	IN
cord-299731-sis9952k	248	34	the	the	DT
cord-299731-sis9952k	248	35	oral	oral	JJ
cord-299731-sis9952k	248	36	intake	intake	NN
cord-299731-sis9952k	248	37	of	of	IN
cord-299731-sis9952k	248	38	NR	NR	NNP
cord-299731-sis9952k	248	39	[	[	-LRB-
cord-299731-sis9952k	248	40	155	155	CD
cord-299731-sis9952k	248	41	]	]	-RRB-
cord-299731-sis9952k	248	42	.	.	.
cord-299731-sis9952k	249	1	Furthermore	furthermore	RB
cord-299731-sis9952k	249	2	,	,	,
cord-299731-sis9952k	249	3	multiple	multiple	JJ
cord-299731-sis9952k	249	4	pathways	pathway	NNS
cord-299731-sis9952k	249	5	for	for	IN
cord-299731-sis9952k	249	6	the	the	DT
cord-299731-sis9952k	249	7	conversion	conversion	NN
cord-299731-sis9952k	249	8	of	of	IN
cord-299731-sis9952k	249	9	NR	NR	NNP
cord-299731-sis9952k	249	10	to	to	IN
cord-299731-sis9952k	249	11	NAD	NAD	NNP
cord-299731-sis9952k	249	12	+	+	CC
cord-299731-sis9952k	249	13	were	be	VBD
cord-299731-sis9952k	249	14	identified	identify	VBN
cord-299731-sis9952k	249	15	in	in	IN
cord-299731-sis9952k	249	16	a	a	DT
cord-299731-sis9952k	249	17	study	study	NN
cord-299731-sis9952k	249	18	with	with	IN
cord-299731-sis9952k	249	19	male	male	JJ
cord-299731-sis9952k	249	20	human	human	JJ
cord-299731-sis9952k	249	21	subjects	subject	NNS
cord-299731-sis9952k	249	22	and	and	CC
cord-299731-sis9952k	249	23	C57Bl6	C57Bl6	NNPS
cord-299731-sis9952k	249	24	/	/	SYM
cord-299731-sis9952k	249	25	J	J	NNP
cord-299731-sis9952k	249	26	mice	mouse	NNS
cord-299731-sis9952k	249	27	[	[	-LRB-
cord-299731-sis9952k	249	28	149	149	CD
cord-299731-sis9952k	249	29	]	]	-RRB-
cord-299731-sis9952k	249	30	.	.	.
cord-299731-sis9952k	250	1	Interestingly	interestingly	RB
cord-299731-sis9952k	250	2	,	,	,
cord-299731-sis9952k	250	3	as	as	IN
cord-299731-sis9952k	250	4	a	a	DT
cord-299731-sis9952k	250	5	response	response	NN
cord-299731-sis9952k	250	6	to	to	IN
cord-299731-sis9952k	250	7	NR	NR	NNP
cord-299731-sis9952k	250	8	,	,	,
cord-299731-sis9952k	250	9	a	a	DT
cord-299731-sis9952k	250	10	remarkable	remarkable	JJ
cord-299731-sis9952k	250	11	increase	increase	NN
cord-299731-sis9952k	250	12	(	(	-LRB-
cord-299731-sis9952k	250	13	45-fold	45-fold	CD
cord-299731-sis9952k	250	14	)	)	-RRB-
cord-299731-sis9952k	250	15	in	in	IN
cord-299731-sis9952k	250	16	NAAD	NAAD	NNP
cord-299731-sis9952k	250	17	was	be	VBD
cord-299731-sis9952k	250	18	reported	report	VBN
cord-299731-sis9952k	250	19	[	[	-LRB-
cord-299731-sis9952k	250	20	149	149	CD
cord-299731-sis9952k	250	21	]	]	-RRB-
cord-299731-sis9952k	250	22	indicating	indicate	VBG
cord-299731-sis9952k	250	23	another	another	DT
cord-299731-sis9952k	250	24	possible	possible	JJ
cord-299731-sis9952k	250	25	conversion	conversion	NN
cord-299731-sis9952k	250	26	pathway	pathway	NN
cord-299731-sis9952k	250	27	of	of	IN
cord-299731-sis9952k	250	28	the	the	DT
cord-299731-sis9952k	250	29	NR	NR	NNP
cord-299731-sis9952k	250	30	to	to	IN
cord-299731-sis9952k	250	31	NAD	NAD	NNP
cord-299731-sis9952k	250	32	+	+	CC
cord-299731-sis9952k	250	33	.	.	.
cord-299731-sis9952k	251	1	These	these	DT
cord-299731-sis9952k	251	2	studies	study	NNS
cord-299731-sis9952k	251	3	suggest	suggest	VBP
cord-299731-sis9952k	251	4	that	that	IN
cord-299731-sis9952k	251	5	causes	cause	NNS
cord-299731-sis9952k	251	6	in	in	IN
cord-299731-sis9952k	251	7	the	the	DT
cord-299731-sis9952k	251	8	variable	variable	JJ
cord-299731-sis9952k	251	9	oral	oral	JJ
cord-299731-sis9952k	251	10	bioavailability	bioavailability	NN
cord-299731-sis9952k	251	11	might	may	MD
cord-299731-sis9952k	251	12	be	be	VB
cord-299731-sis9952k	251	13	revealed	reveal	VBN
cord-299731-sis9952k	251	14	with	with	IN
cord-299731-sis9952k	251	15	further	further	JJ
cord-299731-sis9952k	251	16	investigation	investigation	NN
cord-299731-sis9952k	251	17	of	of	IN
cord-299731-sis9952k	251	18	NR	NR	NNP
cord-299731-sis9952k	251	19	metabolism	metabolism	NN
cord-299731-sis9952k	251	20	and	and	CC
cord-299731-sis9952k	251	21	transport	transport	NN
cord-299731-sis9952k	251	22	.	.	.
cord-299731-sis9952k	252	1	At	at	IN
cord-299731-sis9952k	252	2	the	the	DT
cord-299731-sis9952k	252	3	current	current	JJ
cord-299731-sis9952k	252	4	time	time	NN
cord-299731-sis9952k	252	5	,	,	,
cord-299731-sis9952k	252	6	NR	NR	NNP
cord-299731-sis9952k	252	7	is	be	VBZ
cord-299731-sis9952k	252	8	emerging	emerge	VBG
cord-299731-sis9952k	252	9	as	as	IN
cord-299731-sis9952k	252	10	a	a	DT
cord-299731-sis9952k	252	11	leading	lead	VBG
cord-299731-sis9952k	252	12	candidate	candidate	NN
cord-299731-sis9952k	252	13	due	due	IN
cord-299731-sis9952k	252	14	to	to	IN
cord-299731-sis9952k	252	15	its	-PRON-	PRP$
cord-299731-sis9952k	252	16	bioavailability	bioavailability	NN
cord-299731-sis9952k	252	17	,	,	,
cord-299731-sis9952k	252	18	safety	safety	NN
cord-299731-sis9952k	252	19	,	,	,
cord-299731-sis9952k	252	20	and	and	CC
cord-299731-sis9952k	252	21	strong	strong	JJ
cord-299731-sis9952k	252	22	ability	ability	NN
cord-299731-sis9952k	252	23	to	to	TO
cord-299731-sis9952k	252	24	raise	raise	VB
cord-299731-sis9952k	252	25	NAD	NAD	NNP
cord-299731-sis9952k	253	1	+	+	CC
cord-299731-sis9952k	253	2	content	content	NN
cord-299731-sis9952k	253	3	compared	compare	VBN
cord-299731-sis9952k	253	4	to	to	IN
cord-299731-sis9952k	253	5	other	other	JJ
cord-299731-sis9952k	253	6	precursors	precursor	NNS
cord-299731-sis9952k	253	7	[	[	-LRB-
cord-299731-sis9952k	253	8	149	149	CD
cord-299731-sis9952k	253	9	]	]	-RRB-
cord-299731-sis9952k	253	10	.	.	.
cord-299731-sis9952k	254	1	Among	among	IN
cord-299731-sis9952k	254	2	diverse	diverse	JJ
cord-299731-sis9952k	254	3	NAD	NAD	NNP
cord-299731-sis9952k	254	4	+	+	CC
cord-299731-sis9952k	254	5	precursors	precursor	NNS
cord-299731-sis9952k	254	6	,	,	,
cord-299731-sis9952k	254	7	NMN	NMN	NNP
cord-299731-sis9952k	254	8	and	and	CC
cord-299731-sis9952k	254	9	NR	NR	NNP
cord-299731-sis9952k	254	10	presented	present	VBD
cord-299731-sis9952k	254	11	better	well	JJR
cord-299731-sis9952k	254	12	pharmacokinetic	pharmacokinetic	JJ
cord-299731-sis9952k	254	13	and	and	CC
cord-299731-sis9952k	254	14	pharmacological	pharmacological	JJ
cord-299731-sis9952k	254	15	properties	property	NNS
cord-299731-sis9952k	254	16	[	[	-LRB-
cord-299731-sis9952k	254	17	156	156	CD
cord-299731-sis9952k	254	18	]	]	-RRB-
cord-299731-sis9952k	254	19	.	.	.
cord-299731-sis9952k	255	1	The	the	DT
cord-299731-sis9952k	255	2	bioavailability	bioavailability	NN
cord-299731-sis9952k	255	3	between	between	IN
cord-299731-sis9952k	255	4	the	the	DT
cord-299731-sis9952k	255	5	NAD	NAD	NNP
cord-299731-sis9952k	255	6	+	+	CC
cord-299731-sis9952k	255	7	precursors	precursor	NNS
cord-299731-sis9952k	255	8	(	(	-LRB-
cord-299731-sis9952k	255	9	NMN	NMN	NNP
cord-299731-sis9952k	255	10	,	,	,
cord-299731-sis9952k	255	11	NR	NR	NNP
cord-299731-sis9952k	255	12	,	,	,
cord-299731-sis9952k	255	13	NAM	NAM	NNP
cord-299731-sis9952k	255	14	,	,	,
cord-299731-sis9952k	255	15	and	and	CC
cord-299731-sis9952k	255	16	NA	NA	NNP
cord-299731-sis9952k	255	17	)	)	-RRB-
cord-299731-sis9952k	255	18	was	be	VBD
cord-299731-sis9952k	255	19	assessed	assess	VBN
cord-299731-sis9952k	255	20	in	in	IN
cord-299731-sis9952k	255	21	preclinical	preclinical	JJ
cord-299731-sis9952k	255	22	studies	study	NNS
cord-299731-sis9952k	255	23	as	as	IN
cord-299731-sis9952k	255	24	the	the	DT
cord-299731-sis9952k	255	25	ability	ability	NN
cord-299731-sis9952k	255	26	to	to	TO
cord-299731-sis9952k	255	27	elevate	elevate	VB
cord-299731-sis9952k	255	28	intracellular	intracellular	JJ
cord-299731-sis9952k	255	29	NAD	NAD	NNP
cord-299731-sis9952k	255	30	+	+	CC
cord-299731-sis9952k	255	31	.	.	.
cord-299731-sis9952k	256	1	NR	NR	NNP
cord-299731-sis9952k	256	2	was	be	VBD
cord-299731-sis9952k	256	3	able	able	JJ
cord-299731-sis9952k	256	4	to	to	TO
cord-299731-sis9952k	256	5	increase	increase	VB
cord-299731-sis9952k	256	6	NAD	NAD	NNP
cord-299731-sis9952k	257	1	+	+	CC
cord-299731-sis9952k	257	2	levels	level	NNS
cord-299731-sis9952k	257	3	in	in	IN
cord-299731-sis9952k	257	4	the	the	DT
cord-299731-sis9952k	257	5	liver	liver	NN
cord-299731-sis9952k	257	6	of	of	IN
cord-299731-sis9952k	257	7	mice	mouse	NNS
cord-299731-sis9952k	257	8	,	,	,
cord-299731-sis9952k	257	9	exhibiting	exhibit	VBG
cord-299731-sis9952k	257	10	greater	great	JJR
cord-299731-sis9952k	257	11	oral	oral	JJ
cord-299731-sis9952k	257	12	bioavailability	bioavailability	NN
cord-299731-sis9952k	257	13	than	than	IN
cord-299731-sis9952k	257	14	NAM	NAM	NNP
cord-299731-sis9952k	257	15	,	,	,
cord-299731-sis9952k	257	16	which	which	WDT
cord-299731-sis9952k	257	17	was	be	VBD
cord-299731-sis9952k	257	18	,	,	,
cord-299731-sis9952k	257	19	in	in	IN
cord-299731-sis9952k	257	20	turn	turn	NN
cord-299731-sis9952k	257	21	,	,	,
cord-299731-sis9952k	257	22	more	more	RBR
cord-299731-sis9952k	257	23	orally	orally	RB
cord-299731-sis9952k	257	24	bioavailable	bioavailable	JJ
cord-299731-sis9952k	257	25	than	than	IN
cord-299731-sis9952k	257	26	NA	NA	NNP
cord-299731-sis9952k	257	27	[	[	-LRB-
cord-299731-sis9952k	257	28	149	149	CD
cord-299731-sis9952k	257	29	]	]	-RRB-
cord-299731-sis9952k	257	30	.	.	.
cord-299731-sis9952k	258	1	In	in	IN
cord-299731-sis9952k	258	2	addition	addition	NN
cord-299731-sis9952k	258	3	,	,	,
cord-299731-sis9952k	258	4	animal	animal	NN
cord-299731-sis9952k	258	5	studies	study	NNS
cord-299731-sis9952k	258	6	have	have	VBP
cord-299731-sis9952k	258	7	reported	report	VBN
cord-299731-sis9952k	258	8	that	that	IN
cord-299731-sis9952k	258	9	equimolar	equimolar	JJ
cord-299731-sis9952k	258	10	oral	oral	JJ
cord-299731-sis9952k	258	11	NR	nr	NN
cord-299731-sis9952k	258	12	is	be	VBZ
cord-299731-sis9952k	258	13	superior	superior	JJ
cord-299731-sis9952k	258	14	to	to	IN
cord-299731-sis9952k	258	15	NA	NA	NNP
cord-299731-sis9952k	258	16	and	and	CC
cord-299731-sis9952k	258	17	NAM	NAM	NNP
cord-299731-sis9952k	258	18	in	in	IN
cord-299731-sis9952k	258	19	elevating	elevate	VBG
cord-299731-sis9952k	258	20	NAD	NAD	NNP
cord-299731-sis9952k	259	1	+	+	CC
cord-299731-sis9952k	259	2	content	content	NN
cord-299731-sis9952k	259	3	in	in	IN
cord-299731-sis9952k	259	4	the	the	DT
cord-299731-sis9952k	259	5	liver	liver	NN
cord-299731-sis9952k	259	6	[	[	-LRB-
cord-299731-sis9952k	259	7	149	149	CD
cord-299731-sis9952k	259	8	]	]	-RRB-
cord-299731-sis9952k	259	9	.	.	.
cord-299731-sis9952k	260	1	Similarly	similarly	RB
cord-299731-sis9952k	260	2	,	,	,
cord-299731-sis9952k	260	3	the	the	DT
cord-299731-sis9952k	260	4	NAD	NAD	NNP
cord-299731-sis9952k	260	5	+	+	CC
cord-299731-sis9952k	260	6	content	content	NN
cord-299731-sis9952k	260	7	in	in	IN
cord-299731-sis9952k	260	8	muscles	muscle	NNS
cord-299731-sis9952k	260	9	could	could	MD
cord-299731-sis9952k	260	10	be	be	VB
cord-299731-sis9952k	260	11	significantly	significantly	RB
cord-299731-sis9952k	260	12	increased	increase	VBN
cord-299731-sis9952k	260	13	with	with	IN
cord-299731-sis9952k	260	14	NR	NR	NNP
cord-299731-sis9952k	260	15	and	and	CC
cord-299731-sis9952k	260	16	NA	NA	NNP
cord-299731-sis9952k	260	17	,	,	,
cord-299731-sis9952k	260	18	but	but	CC
cord-299731-sis9952k	260	19	not	not	RB
cord-299731-sis9952k	260	20	with	with	IN
cord-299731-sis9952k	260	21	NMN	NMN	NNP
cord-299731-sis9952k	260	22	[	[	-LRB-
cord-299731-sis9952k	260	23	149	149	CD
cord-299731-sis9952k	260	24	]	]	-RRB-
cord-299731-sis9952k	260	25	.	.	.
cord-299731-sis9952k	261	1	The	the	DT
cord-299731-sis9952k	261	2	three	three	CD
cord-299731-sis9952k	261	3	precursors	precursor	NNS
cord-299731-sis9952k	261	4	(	(	-LRB-
cord-299731-sis9952k	261	5	NA	NA	NNP
cord-299731-sis9952k	261	6	,	,	,
cord-299731-sis9952k	261	7	NMN	NMN	NNP
cord-299731-sis9952k	261	8	,	,	,
cord-299731-sis9952k	261	9	and	and	CC
cord-299731-sis9952k	261	10	NR	NR	NNP
cord-299731-sis9952k	261	11	)	)	-RRB-
cord-299731-sis9952k	261	12	differed	differ	VBD
cord-299731-sis9952k	261	13	in	in	IN
cord-299731-sis9952k	261	14	the	the	DT
cord-299731-sis9952k	261	15	degree	degree	NN
cord-299731-sis9952k	261	16	to	to	TO
cord-299731-sis9952k	261	17	which	which	WDT
cord-299731-sis9952k	261	18	they	-PRON-	PRP
cord-299731-sis9952k	261	19	promote	promote	VBP
cord-299731-sis9952k	261	20	the	the	DT
cord-299731-sis9952k	261	21	accumulation	accumulation	NN
cord-299731-sis9952k	261	22	of	of	IN
cord-299731-sis9952k	261	23	ADPR	ADPR	NNP
cord-299731-sis9952k	261	24	,	,	,
cord-299731-sis9952k	261	25	the	the	DT
cord-299731-sis9952k	261	26	measure	measure	NN
cord-299731-sis9952k	261	27	of	of	IN
cord-299731-sis9952k	261	28	sirtuins	sirtuin	NNS
cord-299731-sis9952k	261	29	activity	activity	NN
cord-299731-sis9952k	261	30	,	,	,
cord-299731-sis9952k	261	31	and	and	CC
cord-299731-sis9952k	261	32	other	other	JJ
cord-299731-sis9952k	261	33	NAD	NAD	NNP
cord-299731-sis9952k	261	34	+	+	CC
cord-299731-sis9952k	262	1	-consuming	-consuming	NN
cord-299731-sis9952k	262	2	activities	activity	NNS
cord-299731-sis9952k	262	3	[	[	-LRB-
cord-299731-sis9952k	262	4	149	149	CD
cord-299731-sis9952k	262	5	]	]	-RRB-
cord-299731-sis9952k	262	6	.	.	.
cord-299731-sis9952k	263	1	Namely	namely	RB
cord-299731-sis9952k	263	2	,	,	,
cord-299731-sis9952k	263	3	NR	NR	NNP
cord-299731-sis9952k	263	4	was	be	VBD
cord-299731-sis9952k	263	5	found	find	VBN
cord-299731-sis9952k	263	6	to	to	TO
cord-299731-sis9952k	263	7	increase	increase	VB
cord-299731-sis9952k	263	8	ADPR~3	ADPR~3	NNP
cord-299731-sis9952k	263	9	more	more	RBR
cord-299731-sis9952k	263	10	than	than	IN
cord-299731-sis9952k	263	11	NAM	NAM	NNP
cord-299731-sis9952k	263	12	,	,	,
cord-299731-sis9952k	263	13	which	which	WDT
cord-299731-sis9952k	263	14	supports	support	VBZ
cord-299731-sis9952k	263	15	NR	NR	NNP
cord-299731-sis9952k	263	16	as	as	IN
cord-299731-sis9952k	263	17	a	a	DT
cord-299731-sis9952k	263	18	favored	favor	VBN
cord-299731-sis9952k	263	19	NAD	NAD	NNP
cord-299731-sis9952k	264	1	+	+	CC
cord-299731-sis9952k	264	2	precursor	precursor	NN
cord-299731-sis9952k	264	3	to	to	TO
cord-299731-sis9952k	264	4	increase	increase	VB
cord-299731-sis9952k	264	5	NAD	NAD	NNP
cord-299731-sis9952k	265	1	+	+	CC
cord-299731-sis9952k	266	1	and	and	CC
cord-299731-sis9952k	266	2	NAD	NAD	NNP
cord-299731-sis9952k	266	3	+	+	CC
cord-299731-sis9952k	267	1	-consuming	-consuming	NN
cord-299731-sis9952k	267	2	activities	activity	NNS
cord-299731-sis9952k	267	3	in	in	IN
cord-299731-sis9952k	267	4	the	the	DT
cord-299731-sis9952k	267	5	liver	liver	NN
cord-299731-sis9952k	267	6	[	[	-LRB-
cord-299731-sis9952k	267	7	149	149	CD
cord-299731-sis9952k	267	8	]	]	-RRB-
cord-299731-sis9952k	267	9	.	.	.
cord-299731-sis9952k	268	1	Moreover	moreover	RB
cord-299731-sis9952k	268	2	,	,	,
cord-299731-sis9952k	268	3	the	the	DT
cord-299731-sis9952k	268	4	activity	activity	NN
cord-299731-sis9952k	268	5	of	of	IN
cord-299731-sis9952k	268	6	sirtuins	sirtuin	NNS
cord-299731-sis9952k	268	7	was	be	VBD
cord-299731-sis9952k	268	8	stimulated	stimulate	VBN
cord-299731-sis9952k	268	9	after	after	IN
cord-299731-sis9952k	268	10	NR	nr	NN
cord-299731-sis9952k	268	11	-	-	HYPH
cord-299731-sis9952k	268	12	induced	induce	VBN
cord-299731-sis9952k	268	13	NAD	NAD	NNP
cord-299731-sis9952k	268	14	+	+	CC
cord-299731-sis9952k	268	15	levels	level	NNS
cord-299731-sis9952k	268	16	increased	increase	VBD
cord-299731-sis9952k	268	17	[	[	-LRB-
cord-299731-sis9952k	268	18	37	37	CD
cord-299731-sis9952k	268	19	]	]	-RRB-
cord-299731-sis9952k	268	20	.	.	.
cord-299731-sis9952k	269	1	Both	both	DT
cord-299731-sis9952k	269	2	SIRT1	SIRT1	NNS
cord-299731-sis9952k	269	3	and	and	CC
cord-299731-sis9952k	269	4	SIRT3	sirt3	JJ
cord-299731-sis9952k	269	5	activities	activity	NNS
cord-299731-sis9952k	269	6	increased	increase	VBD
cord-299731-sis9952k	269	7	in	in	IN
cord-299731-sis9952k	269	8	vitro	vitro	FW
cord-299731-sis9952k	269	9	and	and	CC
cord-299731-sis9952k	269	10	in	in	IN
cord-299731-sis9952k	269	11	vivo	vivo	NNP
cord-299731-sis9952k	269	12	[	[	-LRB-
cord-299731-sis9952k	269	13	37	37	CD
cord-299731-sis9952k	269	14	]	]	-RRB-
cord-299731-sis9952k	269	15	,	,	,
cord-299731-sis9952k	269	16	which	which	WDT
cord-299731-sis9952k	269	17	favors	favor	VBZ
cord-299731-sis9952k	269	18	the	the	DT
cord-299731-sis9952k	269	19	hypothesis	hypothesis	NN
cord-299731-sis9952k	269	20	that	that	WDT
cord-299731-sis9952k	269	21	NR	NR	NNP
cord-299731-sis9952k	269	22	can	can	MD
cord-299731-sis9952k	269	23	increase	increase	VB
cord-299731-sis9952k	269	24	NAD	NAD	NNP
cord-299731-sis9952k	269	25	+	+	CC
cord-299731-sis9952k	269	26	levels	level	NNS
cord-299731-sis9952k	269	27	in	in	IN
cord-299731-sis9952k	269	28	at	at	IN
cord-299731-sis9952k	269	29	least	least	JJS
cord-299731-sis9952k	269	30	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	269	31	and	and	CC
cord-299731-sis9952k	269	32	nuclear	nuclear	JJ
cord-299731-sis9952k	269	33	compartments	compartment	NNS
cord-299731-sis9952k	269	34	.	.	.
cord-299731-sis9952k	270	1	NR	NR	NNP
cord-299731-sis9952k	270	2	's	's	POS
cord-299731-sis9952k	270	3	ability	ability	NN
cord-299731-sis9952k	270	4	to	to	TO
cord-299731-sis9952k	270	5	increase	increase	VB
cord-299731-sis9952k	270	6	NAD	NAD	NNP
cord-299731-sis9952k	270	7	+	+	CC
cord-299731-sis9952k	270	8	in	in	IN
cord-299731-sis9952k	270	9	different	different	JJ
cord-299731-sis9952k	270	10	subcellular	subcellular	JJ
cord-299731-sis9952k	270	11	compartments	compartment	NNS
cord-299731-sis9952k	270	12	represents	represent	VBZ
cord-299731-sis9952k	270	13	the	the	DT
cord-299731-sis9952k	270	14	crucial	crucial	JJ
cord-299731-sis9952k	270	15	difference	difference	NN
cord-299731-sis9952k	270	16	compared	compare	VBN
cord-299731-sis9952k	270	17	to	to	IN
cord-299731-sis9952k	270	18	other	other	JJ
cord-299731-sis9952k	270	19	approaches	approach	NNS
cord-299731-sis9952k	270	20	of	of	IN
cord-299731-sis9952k	270	21	increasing	increase	VBG
cord-299731-sis9952k	270	22	intracellular	intracellular	JJ
cord-299731-sis9952k	270	23	NAD	NAD	NNP
cord-299731-sis9952k	270	24	+	+	CC
cord-299731-sis9952k	270	25	levels	level	NNS
cord-299731-sis9952k	270	26	.	.	.
cord-299731-sis9952k	271	1	Although	although	IN
cord-299731-sis9952k	271	2	all	all	DT
cord-299731-sis9952k	271	3	three	three	CD
cord-299731-sis9952k	271	4	precursors	precursor	NNS
cord-299731-sis9952k	271	5	,	,	,
cord-299731-sis9952k	271	6	NA	NA	NNP
cord-299731-sis9952k	271	7	,	,	,
cord-299731-sis9952k	271	8	NAM	NAM	NNP
cord-299731-sis9952k	271	9	,	,	,
cord-299731-sis9952k	271	10	and	and	CC
cord-299731-sis9952k	271	11	NR	NR	NNP
cord-299731-sis9952k	271	12	can	can	MD
cord-299731-sis9952k	271	13	raise	raise	VB
cord-299731-sis9952k	271	14	both	both	CC
cord-299731-sis9952k	271	15	NAD	NAD	NNP
cord-299731-sis9952k	271	16	+	+	CC
cord-299731-sis9952k	271	17	and	and	CC
cord-299731-sis9952k	271	18	NADP	NADP	NNP
cord-299731-sis9952k	271	19	+	+	SYM
cord-299731-sis9952k	271	20	levels	level	NNS
cord-299731-sis9952k	271	21	[	[	-LRB-
cord-299731-sis9952k	271	22	14	14	CD
cord-299731-sis9952k	271	23	,	,	,
cord-299731-sis9952k	271	24	149	149	CD
cord-299731-sis9952k	271	25	,	,	,
cord-299731-sis9952k	271	26	157	157	CD
cord-299731-sis9952k	271	27	]	]	-RRB-
cord-299731-sis9952k	271	28	,	,	,
cord-299731-sis9952k	271	29	they	-PRON-	PRP
cord-299731-sis9952k	271	30	all	all	DT
cord-299731-sis9952k	271	31	exhibit	exhibit	VBP
cord-299731-sis9952k	271	32	distinct	distinct	JJ
cord-299731-sis9952k	271	33	physiological	physiological	JJ
cord-299731-sis9952k	271	34	responses	response	NNS
cord-299731-sis9952k	271	35	.	.	.
cord-299731-sis9952k	272	1	For	for	IN
cord-299731-sis9952k	272	2	example	example	NN
cord-299731-sis9952k	272	3	,	,	,
cord-299731-sis9952k	272	4	NA	NA	NNP
cord-299731-sis9952k	272	5	shows	show	VBZ
cord-299731-sis9952k	272	6	lowering	lower	VBG
cord-299731-sis9952k	272	7	effects	effect	NNS
cord-299731-sis9952k	272	8	on	on	IN
cord-299731-sis9952k	272	9	blood	blood	NN
cord-299731-sis9952k	272	10	lipid	lipid	NN
cord-299731-sis9952k	272	11	levels	level	NNS
cord-299731-sis9952k	272	12	,	,	,
cord-299731-sis9952k	272	13	and	and	CC
cord-299731-sis9952k	272	14	it	-PRON-	PRP
cord-299731-sis9952k	272	15	is	be	VBZ
cord-299731-sis9952k	272	16	used	use	VBN
cord-299731-sis9952k	272	17	to	to	TO
cord-299731-sis9952k	272	18	treat	treat	VB
cord-299731-sis9952k	272	19	dyslipidemia	dyslipidemia	NN
cord-299731-sis9952k	272	20	[	[	-LRB-
cord-299731-sis9952k	272	21	151	151	CD
cord-299731-sis9952k	272	22	]	]	-RRB-
cord-299731-sis9952k	272	23	.	.	.
cord-299731-sis9952k	273	1	However	however	RB
cord-299731-sis9952k	273	2	,	,	,
cord-299731-sis9952k	273	3	NA	NA	NNP
cord-299731-sis9952k	273	4	is	be	VBZ
cord-299731-sis9952k	273	5	implicated	implicate	VBN
cord-299731-sis9952k	273	6	with	with	IN
cord-299731-sis9952k	273	7	flushing	flush	VBG
cord-299731-sis9952k	273	8	at	at	IN
cord-299731-sis9952k	273	9	doses	dose	NNS
cord-299731-sis9952k	273	10	higher	high	JJR
cord-299731-sis9952k	273	11	than	than	IN
cord-299731-sis9952k	273	12	50	50	CD
cord-299731-sis9952k	273	13	mg	mg	NNP
cord-299731-sis9952k	273	14	/	/	SYM
cord-299731-sis9952k	273	15	day	day	NN
cord-299731-sis9952k	273	16	[	[	-LRB-
cord-299731-sis9952k	273	17	151	151	CD
cord-299731-sis9952k	273	18	]	]	-RRB-
cord-299731-sis9952k	273	19	.	.	.
cord-299731-sis9952k	274	1	On	on	IN
cord-299731-sis9952k	274	2	the	the	DT
cord-299731-sis9952k	274	3	contrary	contrary	NN
cord-299731-sis9952k	274	4	,	,	,
cord-299731-sis9952k	274	5	NAM	NAM	NNP
cord-299731-sis9952k	274	6	does	do	VBZ
cord-299731-sis9952k	274	7	not	not	RB
cord-299731-sis9952k	274	8	affect	affect	VB
cord-299731-sis9952k	274	9	lipid	lipid	NN
cord-299731-sis9952k	274	10	blood	blood	NN
cord-299731-sis9952k	274	11	levels	level	NNS
cord-299731-sis9952k	274	12	,	,	,
cord-299731-sis9952k	274	13	yet	yet	CC
cord-299731-sis9952k	274	14	it	-PRON-	PRP
cord-299731-sis9952k	274	15	can	can	MD
cord-299731-sis9952k	274	16	exhibit	exhibit	VB
cord-299731-sis9952k	274	17	sirtuin	sirtuin	NN
cord-299731-sis9952k	274	18	-	-	HYPH
cord-299731-sis9952k	274	19	inhibiting	inhibit	VBG
cord-299731-sis9952k	274	20	effects	effect	NNS
cord-299731-sis9952k	274	21	at	at	IN
cord-299731-sis9952k	274	22	higher	high	JJR
cord-299731-sis9952k	274	23	doses	dose	NNS
cord-299731-sis9952k	274	24	[	[	-LRB-
cord-299731-sis9952k	274	25	116	116	CD
cord-299731-sis9952k	274	26	,	,	,
cord-299731-sis9952k	274	27	149	149	CD
cord-299731-sis9952k	274	28	]	]	-RRB-
cord-299731-sis9952k	274	29	.	.	.
cord-299731-sis9952k	275	1	Among	among	IN
cord-299731-sis9952k	275	2	the	the	DT
cord-299731-sis9952k	275	3	three	three	CD
cord-299731-sis9952k	275	4	mentioned	mention	VBN
cord-299731-sis9952k	275	5	precursors	precursor	NNS
cord-299731-sis9952k	275	6	,	,	,
cord-299731-sis9952k	275	7	only	only	RB
cord-299731-sis9952k	275	8	NR	NR	NNP
cord-299731-sis9952k	275	9	could	could	MD
cord-299731-sis9952k	275	10	prolong	prolong	VB
cord-299731-sis9952k	275	11	survival	survival	NN
cord-299731-sis9952k	275	12	and	and	CC
cord-299731-sis9952k	275	13	induce	induce	VB
cord-299731-sis9952k	275	14	hematopoietic	hematopoietic	JJ
cord-299731-sis9952k	275	15	stem	stem	NN
cord-299731-sis9952k	275	16	cell	cell	NN
cord-299731-sis9952k	275	17	regeneration	regeneration	NN
cord-299731-sis9952k	275	18	,	,	,
cord-299731-sis9952k	275	19	as	as	IN
cord-299731-sis9952k	275	20	documented	document	VBN
cord-299731-sis9952k	275	21	in	in	IN
cord-299731-sis9952k	275	22	a	a	DT
cord-299731-sis9952k	275	23	study	study	NN
cord-299731-sis9952k	275	24	with	with	IN
cord-299731-sis9952k	275	25	mice	mouse	NNS
cord-299731-sis9952k	275	26	treated	treat	VBN
cord-299731-sis9952k	275	27	with	with	IN
cord-299731-sis9952k	275	28	irradiation	irradiation	NN
cord-299731-sis9952k	275	29	[	[	-LRB-
cord-299731-sis9952k	275	30	158	158	CD
cord-299731-sis9952k	275	31	]	]	-RRB-
cord-299731-sis9952k	275	32	.	.	.
cord-299731-sis9952k	276	1	Furthermore	furthermore	RB
cord-299731-sis9952k	276	2	,	,	,
cord-299731-sis9952k	276	3	orally	orally	RB
cord-299731-sis9952k	276	4	administered	administer	VBN
cord-299731-sis9952k	276	5	NR	NR	NNP
cord-299731-sis9952k	276	6	was	be	VBD
cord-299731-sis9952k	276	7	found	find	VBN
cord-299731-sis9952k	276	8	to	to	TO
cord-299731-sis9952k	276	9	improve	improve	VB
cord-299731-sis9952k	276	10	resistance	resistance	NN
cord-299731-sis9952k	276	11	to	to	IN
cord-299731-sis9952k	276	12	and	and	CC
cord-299731-sis9952k	276	13	reversal	reversal	NN
cord-299731-sis9952k	276	14	of	of	IN
cord-299731-sis9952k	276	15	chemotherapeutic	chemotherapeutic	JJ
cord-299731-sis9952k	276	16	neuropathy	neuropathy	NN
cord-299731-sis9952k	276	17	[	[	-LRB-
cord-299731-sis9952k	276	18	159	159	CD
cord-299731-sis9952k	276	19	]	]	-RRB-
cord-299731-sis9952k	276	20	.	.	.
cord-299731-sis9952k	277	1	This	this	DT
cord-299731-sis9952k	277	2	implies	imply	VBZ
cord-299731-sis9952k	277	3	advantages	advantage	NNS
cord-299731-sis9952k	277	4	of	of	IN
cord-299731-sis9952k	277	5	the	the	DT
cord-299731-sis9952k	277	6	NR	NR	NNP
cord-299731-sis9952k	277	7	precursor	precursor	NN
cord-299731-sis9952k	277	8	for	for	IN
cord-299731-sis9952k	277	9	potential	potential	JJ
cord-299731-sis9952k	277	10	use	use	NN
cord-299731-sis9952k	277	11	in	in	IN
cord-299731-sis9952k	277	12	cancer	cancer	NN
cord-299731-sis9952k	277	13	patients	patient	NNS
cord-299731-sis9952k	277	14	undergoing	undergo	VBG
cord-299731-sis9952k	277	15	chemo	chemo	NN
cord-299731-sis9952k	277	16	-	-	,
cord-299731-sis9952k	277	17	or	or	CC
cord-299731-sis9952k	277	18	radiotherapy	radiotherapy	NN
cord-299731-sis9952k	277	19	.	.	.
cord-299731-sis9952k	278	1	The	the	DT
cord-299731-sis9952k	278	2	bioavailability	bioavailability	NN
cord-299731-sis9952k	278	3	of	of	IN
cord-299731-sis9952k	278	4	NAD	NAD	NNP
cord-299731-sis9952k	278	5	+	+	CC
cord-299731-sis9952k	278	6	precursors	precursor	NNS
cord-299731-sis9952k	278	7	can	can	MD
cord-299731-sis9952k	278	8	be	be	VB
cord-299731-sis9952k	278	9	assessed	assess	VBN
cord-299731-sis9952k	278	10	by	by	IN
cord-299731-sis9952k	278	11	measuring	measure	VBG
cord-299731-sis9952k	278	12	NAAD	NAAD	NNP
cord-299731-sis9952k	278	13	levels	level	NNS
cord-299731-sis9952k	278	14	.	.	.
cord-299731-sis9952k	279	1	Namely	namely	RB
cord-299731-sis9952k	279	2	,	,	,
cord-299731-sis9952k	279	3	NAAD	NAAD	NNP
cord-299731-sis9952k	279	4	represents	represent	VBZ
cord-299731-sis9952k	279	5	the	the	DT
cord-299731-sis9952k	279	6	most	most	RBS
cord-299731-sis9952k	279	7	sensitive	sensitive	JJ
cord-299731-sis9952k	279	8	biomarker	biomarker	NN
cord-299731-sis9952k	279	9	of	of	IN
cord-299731-sis9952k	279	10	effective	effective	JJ
cord-299731-sis9952k	279	11	NAD	NAD	NNP
cord-299731-sis9952k	279	12	+	+	CC
cord-299731-sis9952k	279	13	supplementation	supplementation	NN
cord-299731-sis9952k	279	14	since	since	IN
cord-299731-sis9952k	279	15	it	-PRON-	PRP
cord-299731-sis9952k	279	16	is	be	VBZ
cord-299731-sis9952k	279	17	undetectable	undetectable	JJ
cord-299731-sis9952k	279	18	in	in	IN
cord-299731-sis9952k	279	19	the	the	DT
cord-299731-sis9952k	279	20	blood	blood	NN
cord-299731-sis9952k	279	21	prior	prior	RB
cord-299731-sis9952k	279	22	to	to	IN
cord-299731-sis9952k	279	23	supplementation	supplementation	NN
cord-299731-sis9952k	279	24	,	,	,
cord-299731-sis9952k	279	25	and	and	CC
cord-299731-sis9952k	279	26	the	the	DT
cord-299731-sis9952k	279	27	increase	increase	NN
cord-299731-sis9952k	279	28	of	of	IN
cord-299731-sis9952k	279	29	its	-PRON-	PRP$
cord-299731-sis9952k	279	30	levels	level	NNS
cord-299731-sis9952k	279	31	has	have	VBZ
cord-299731-sis9952k	279	32	been	be	VBN
cord-299731-sis9952k	279	33	observed	observe	VBN
cord-299731-sis9952k	279	34	in	in	IN
cord-299731-sis9952k	279	35	the	the	DT
cord-299731-sis9952k	279	36	liver	liver	NN
cord-299731-sis9952k	279	37	after	after	IN
cord-299731-sis9952k	279	38	orally	orally	RB
cord-299731-sis9952k	279	39	administered	administer	VBD
cord-299731-sis9952k	279	40	NAD	NAD	NNP
cord-299731-sis9952k	279	41	+	+	CC
cord-299731-sis9952k	279	42	precursors	precursor	NNS
cord-299731-sis9952k	279	43	.	.	.
cord-299731-sis9952k	280	1	NR	NR	NNP
cord-299731-sis9952k	280	2	was	be	VBD
cord-299731-sis9952k	280	3	found	find	VBN
cord-299731-sis9952k	280	4	to	to	TO
cord-299731-sis9952k	280	5	increase	increase	VB
cord-299731-sis9952k	280	6	NAAD	NAAD	NNP
cord-299731-sis9952k	280	7	by	by	IN
cord-299731-sis9952k	280	8	at	at	RB
cord-299731-sis9952k	280	9	least	least	RBS
cord-299731-sis9952k	280	10	45-fold	45-fold	CD
cord-299731-sis9952k	280	11	compared	compare	VBN
cord-299731-sis9952k	280	12	to	to	IN
cord-299731-sis9952k	280	13	baseline	baseline	JJ
cord-299731-sis9952k	280	14	[	[	-LRB-
cord-299731-sis9952k	280	15	149	149	CD
cord-299731-sis9952k	280	16	]	]	-RRB-
cord-299731-sis9952k	280	17	.	.	.
cord-299731-sis9952k	281	1	In	in	IN
cord-299731-sis9952k	281	2	addition	addition	NN
cord-299731-sis9952k	281	3	,	,	,
cord-299731-sis9952k	281	4	NR	NR	NNP
cord-299731-sis9952k	281	5	could	could	MD
cord-299731-sis9952k	281	6	significantly	significantly	RB
cord-299731-sis9952k	281	7	elevate	elevate	VB
cord-299731-sis9952k	281	8	NAAD	NAAD	NNP
cord-299731-sis9952k	281	9	heart	heart	NN
cord-299731-sis9952k	281	10	content	content	NN
cord-299731-sis9952k	281	11	,	,	,
cord-299731-sis9952k	281	12	where	where	WRB
cord-299731-sis9952k	281	13	the	the	DT
cord-299731-sis9952k	281	14	increase	increase	NN
cord-299731-sis9952k	281	15	of	of	IN
cord-299731-sis9952k	281	16	NAD	NAD	NNP
cord-299731-sis9952k	281	17	+	+	CC
cord-299731-sis9952k	281	18	occurs	occur	VBZ
cord-299731-sis9952k	281	19	in	in	IN
cord-299731-sis9952k	281	20	the	the	DT
cord-299731-sis9952k	281	21	absence	absence	NN
cord-299731-sis9952k	281	22	of	of	IN
cord-299731-sis9952k	281	23	a	a	DT
cord-299731-sis9952k	281	24	steady	steady	JJ
cord-299731-sis9952k	281	25	-	-	HYPH
cord-299731-sis9952k	281	26	state	state	NN
cord-299731-sis9952k	281	27	NAD	NAD	NNP
cord-299731-sis9952k	281	28	+	+	CC
cord-299731-sis9952k	281	29	increase	increase	NN
cord-299731-sis9952k	281	30	[	[	-LRB-
cord-299731-sis9952k	281	31	149	149	CD
cord-299731-sis9952k	281	32	]	]	-RRB-
cord-299731-sis9952k	281	33	.	.	.
cord-299731-sis9952k	282	1	Surprisingly	surprisingly	RB
cord-299731-sis9952k	282	2	NA	NA	NNP
cord-299731-sis9952k	282	3	,	,	,
cord-299731-sis9952k	282	4	the	the	DT
cord-299731-sis9952k	282	5	only	only	JJ
cord-299731-sis9952k	282	6	precursor	precursor	NN
cord-299731-sis9952k	282	7	expected	expect	VBN
cord-299731-sis9952k	282	8	to	to	TO
cord-299731-sis9952k	282	9	convert	convert	VB
cord-299731-sis9952k	282	10	to	to	IN
cord-299731-sis9952k	282	11	NAD	NAD	NNP
cord-299731-sis9952k	282	12	+	+	CC
cord-299731-sis9952k	282	13	through	through	IN
cord-299731-sis9952k	282	14	a	a	DT
cord-299731-sis9952k	282	15	NAAD	NAAD	NNP
cord-299731-sis9952k	282	16	intermediate	intermediate	JJ
cord-299731-sis9952k	282	17	,	,	,
cord-299731-sis9952k	282	18	produced	produce	VBD
cord-299731-sis9952k	282	19	the	the	DT
cord-299731-sis9952k	282	20	least	least	JJS
cord-299731-sis9952k	282	21	NAAD	NAAD	NNP
cord-299731-sis9952k	282	22	,	,	,
cord-299731-sis9952k	282	23	while	while	IN
cord-299731-sis9952k	282	24	NAM	NAM	NNP
cord-299731-sis9952k	282	25	and	and	CC
cord-299731-sis9952k	282	26	NR	NR	NNP
cord-299731-sis9952k	282	27	both	both	DT
cord-299731-sis9952k	282	28	produced	produce	VBD
cord-299731-sis9952k	282	29	peaks	peak	NNS
cord-299731-sis9952k	282	30	of	of	IN
cord-299731-sis9952k	282	31	hepatic	hepatic	JJ
cord-299731-sis9952k	282	32	NAAD	NAAD	NNP
cord-299731-sis9952k	282	33	[	[	-LRB-
cord-299731-sis9952k	282	34	149	149	CD
cord-299731-sis9952k	282	35	]	]	-RRB-
cord-299731-sis9952k	282	36	.	.	.
cord-299731-sis9952k	283	1	High	high	JJ
cord-299731-sis9952k	283	2	availability	availability	NN
cord-299731-sis9952k	283	3	of	of	IN
cord-299731-sis9952k	283	4	NR	NR	NNP
cord-299731-sis9952k	283	5	has	have	VBZ
cord-299731-sis9952k	283	6	been	be	VBN
cord-299731-sis9952k	283	7	observed	observe	VBN
cord-299731-sis9952k	283	8	in	in	IN
cord-299731-sis9952k	283	9	the	the	DT
cord-299731-sis9952k	283	10	normal	normal	JJ
cord-299731-sis9952k	283	11	human	human	JJ
cord-299731-sis9952k	283	12	diet	diet	NN
cord-299731-sis9952k	283	13	.	.	.
cord-299731-sis9952k	284	1	NR	NR	NNP
cord-299731-sis9952k	284	2	does	do	VBZ
cord-299731-sis9952k	284	3	not	not	RB
cord-299731-sis9952k	284	4	require	require	VB
cord-299731-sis9952k	284	5	conversion	conversion	NN
cord-299731-sis9952k	284	6	to	to	TO
cord-299731-sis9952k	284	7	enter	enter	VB
cord-299731-sis9952k	284	8	the	the	DT
cord-299731-sis9952k	284	9	cell	cell	NN
cord-299731-sis9952k	284	10	,	,	,
cord-299731-sis9952k	284	11	which	which	WDT
cord-299731-sis9952k	284	12	could	could	MD
cord-299731-sis9952k	284	13	partially	partially	RB
cord-299731-sis9952k	284	14	explain	explain	VB
cord-299731-sis9952k	284	15	the	the	DT
cord-299731-sis9952k	284	16	high	high	JJ
cord-299731-sis9952k	284	17	level	level	NN
cord-299731-sis9952k	284	18	of	of	IN
cord-299731-sis9952k	284	19	availability	availability	NN
cord-299731-sis9952k	284	20	.	.	.
cord-299731-sis9952k	285	1	On	on	IN
cord-299731-sis9952k	285	2	the	the	DT
cord-299731-sis9952k	285	3	contrary	contrary	NN
cord-299731-sis9952k	285	4	,	,	,
cord-299731-sis9952k	285	5	NAD	NAD	NNP
cord-299731-sis9952k	285	6	+	+	CC
cord-299731-sis9952k	285	7	and	and	CC
cord-299731-sis9952k	285	8	its	-PRON-	PRP$
cord-299731-sis9952k	285	9	precursors	precursor	NNS
cord-299731-sis9952k	285	10	have	have	VBP
cord-299731-sis9952k	285	11	to	to	TO
cord-299731-sis9952k	285	12	be	be	VB
cord-299731-sis9952k	285	13	converted	convert	VBN
cord-299731-sis9952k	285	14	to	to	IN
cord-299731-sis9952k	285	15	either	either	CC
cord-299731-sis9952k	285	16	NR	NR	NNP
cord-299731-sis9952k	285	17	or	or	CC
cord-299731-sis9952k	285	18	NAM	NAM	NNP
cord-299731-sis9952k	285	19	before	before	IN
cord-299731-sis9952k	285	20	entering	enter	VBG
cord-299731-sis9952k	285	21	the	the	DT
cord-299731-sis9952k	285	22	cell	cell	NN
cord-299731-sis9952k	285	23	[	[	-LRB-
cord-299731-sis9952k	285	24	153	153	CD
cord-299731-sis9952k	285	25	]	]	-RRB-
cord-299731-sis9952k	285	26	.	.	.
cord-299731-sis9952k	286	1	While	while	IN
cord-299731-sis9952k	286	2	NAD	NAD	NNP
cord-299731-sis9952k	286	3	+	+	CC
cord-299731-sis9952k	286	4	and	and	CC
cord-299731-sis9952k	286	5	NMN	NMN	NNP
cord-299731-sis9952k	286	6	are	be	VBP
cord-299731-sis9952k	286	7	being	be	VBG
cord-299731-sis9952k	286	8	converted	convert	VBN
cord-299731-sis9952k	286	9	to	to	IN
cord-299731-sis9952k	286	10	NR	NR	NNP
cord-299731-sis9952k	286	11	extracellularly	extracellularly	RB
cord-299731-sis9952k	286	12	by	by	IN
cord-299731-sis9952k	286	13	CD73	CD73	NNP
cord-299731-sis9952k	286	14	[	[	-LRB-
cord-299731-sis9952k	286	15	28	28	CD
cord-299731-sis9952k	286	16	]	]	-RRB-
cord-299731-sis9952k	286	17	,	,	,
cord-299731-sis9952k	286	18	their	-PRON-	PRP$
cord-299731-sis9952k	286	19	cellular	cellular	JJ
cord-299731-sis9952k	286	20	conversion	conversion	NN
cord-299731-sis9952k	286	21	depends	depend	VBZ
cord-299731-sis9952k	286	22	on	on	IN
cord-299731-sis9952k	286	23	the	the	DT
cord-299731-sis9952k	286	24	NMRK	NMRK	NNP
cord-299731-sis9952k	286	25	pathway	pathway	NN
cord-299731-sis9952k	286	26	[	[	-LRB-
cord-299731-sis9952k	286	27	153	153	CD
cord-299731-sis9952k	286	28	,	,	,
cord-299731-sis9952k	286	29	160	160	CD
cord-299731-sis9952k	286	30	]	]	-RRB-
cord-299731-sis9952k	286	31	.	.	.
cord-299731-sis9952k	287	1	However	however	RB
cord-299731-sis9952k	287	2	,	,	,
cord-299731-sis9952k	287	3	a	a	DT
cord-299731-sis9952k	287	4	NMN	NMN	NNP
cord-299731-sis9952k	287	5	specific	specific	JJ
cord-299731-sis9952k	287	6	transporter	transporter	NN
cord-299731-sis9952k	287	7	in	in	IN
cord-299731-sis9952k	287	8	the	the	DT
cord-299731-sis9952k	287	9	gut	gut	NN
cord-299731-sis9952k	287	10	encoded	encode	VBN
cord-299731-sis9952k	287	11	by	by	IN
cord-299731-sis9952k	287	12	Slc12a8	Slc12a8	NNP
cord-299731-sis9952k	287	13	gene	gene	NN
cord-299731-sis9952k	287	14	,	,	,
cord-299731-sis9952k	287	15	has	have	VBZ
cord-299731-sis9952k	287	16	recently	recently	RB
cord-299731-sis9952k	287	17	been	be	VBN
cord-299731-sis9952k	287	18	identified	identify	VBN
cord-299731-sis9952k	287	19	by	by	IN
cord-299731-sis9952k	287	20	Grozio	Grozio	NNP
cord-299731-sis9952k	287	21	et	et	NNP
cord-299731-sis9952k	287	22	al	al	NNP
cord-299731-sis9952k	287	23	.	.	.
cord-299731-sis9952k	288	1	[	[	-LRB-
cord-299731-sis9952k	288	2	161	161	CD
cord-299731-sis9952k	288	3	]	]	-RRB-
cord-299731-sis9952k	288	4	.	.	.
cord-299731-sis9952k	289	1	Hence	hence	RB
cord-299731-sis9952k	289	2	,	,	,
cord-299731-sis9952k	289	3	the	the	DT
cord-299731-sis9952k	289	4	utilization	utilization	NN
cord-299731-sis9952k	289	5	of	of	IN
cord-299731-sis9952k	289	6	NR	NR	NNP
cord-299731-sis9952k	289	7	and	and	CC
cord-299731-sis9952k	289	8	extracellular	extracellular	JJ
cord-299731-sis9952k	289	9	NAD	NAD	NNP
cord-299731-sis9952k	289	10	+	+	CC
cord-299731-sis9952k	289	11	are	be	VBP
cord-299731-sis9952k	289	12	limited	limit	VBN
cord-299731-sis9952k	289	13	by	by	IN
cord-299731-sis9952k	289	14	the	the	DT
cord-299731-sis9952k	289	15	activity	activity	NN
cord-299731-sis9952k	289	16	of	of	IN
cord-299731-sis9952k	289	17	the	the	DT
cord-299731-sis9952k	289	18	NMRK	NMRK	NNP
cord-299731-sis9952k	289	19	pathway	pathway	NN
cord-299731-sis9952k	289	20	[	[	-LRB-
cord-299731-sis9952k	289	21	153	153	CD
cord-299731-sis9952k	289	22	]	]	-RRB-
cord-299731-sis9952k	289	23	.	.	.
cord-299731-sis9952k	290	1	Conversely	conversely	RB
cord-299731-sis9952k	290	2	,	,	,
cord-299731-sis9952k	290	3	another	another	DT
cord-299731-sis9952k	290	4	candidate	candidate	NN
cord-299731-sis9952k	290	5	has	have	VBZ
cord-299731-sis9952k	290	6	recently	recently	RB
cord-299731-sis9952k	290	7	emerged	emerge	VBN
cord-299731-sis9952k	290	8	that	that	WDT
cord-299731-sis9952k	290	9	can	can	MD
cord-299731-sis9952k	290	10	increase	increase	VB
cord-299731-sis9952k	290	11	NAD	NAD	NNP
cord-299731-sis9952k	291	1	+	+	CC
cord-299731-sis9952k	291	2	levels	level	NNS
cord-299731-sis9952k	291	3	through	through	IN
cord-299731-sis9952k	291	4	NMRK	NMRK	NNP
cord-299731-sis9952k	291	5	independent	independent	JJ
cord-299731-sis9952k	291	6	pathway	pathway	NN
cord-299731-sis9952k	291	7	.	.	.
cord-299731-sis9952k	292	1	Namely	namely	RB
cord-299731-sis9952k	292	2	,	,	,
cord-299731-sis9952k	292	3	one	one	CD
cord-299731-sis9952k	292	4	study	study	NN
cord-299731-sis9952k	292	5	reported	report	VBD
cord-299731-sis9952k	292	6	that	that	IN
cord-299731-sis9952k	292	7	NR	NR	NNP
cord-299731-sis9952k	292	8	reduced	reduce	VBN
cord-299731-sis9952k	292	9	form	form	NN
cord-299731-sis9952k	292	10	(	(	-LRB-
cord-299731-sis9952k	292	11	NRH	NRH	NNP
cord-299731-sis9952k	292	12	)	)	-RRB-
cord-299731-sis9952k	292	13	is	be	VBZ
cord-299731-sis9952k	292	14	bioavailable	bioavailable	JJ
cord-299731-sis9952k	292	15	in	in	IN
cord-299731-sis9952k	292	16	mice	mouse	NNS
cord-299731-sis9952k	292	17	and	and	CC
cord-299731-sis9952k	292	18	indicated	indicate	VBD
cord-299731-sis9952k	292	19	its	-PRON-	PRP$
cord-299731-sis9952k	292	20	great	great	JJ
cord-299731-sis9952k	292	21	potential	potential	NN
cord-299731-sis9952k	292	22	for	for	IN
cord-299731-sis9952k	292	23	therapeutic	therapeutic	JJ
cord-299731-sis9952k	292	24	application	application	NN
cord-299731-sis9952k	292	25	[	[	-LRB-
cord-299731-sis9952k	292	26	162	162	CD
cord-299731-sis9952k	292	27	]	]	-RRB-
cord-299731-sis9952k	292	28	.	.	.
cord-299731-sis9952k	293	1	Since	since	IN
cord-299731-sis9952k	293	2	NR	NR	NNP
cord-299731-sis9952k	293	3	is	be	VBZ
cord-299731-sis9952k	293	4	unstable	unstable	JJ
cord-299731-sis9952k	293	5	in	in	IN
cord-299731-sis9952k	293	6	blood	blood	NN
cord-299731-sis9952k	293	7	circulation	circulation	NN
cord-299731-sis9952k	293	8	,	,	,
cord-299731-sis9952k	293	9	partially	partially	RB
cord-299731-sis9952k	293	10	due	due	JJ
cord-299731-sis9952k	293	11	to	to	IN
cord-299731-sis9952k	293	12	degradation	degradation	NN
cord-299731-sis9952k	293	13	to	to	IN
cord-299731-sis9952k	293	14	NAM	NAM	NNP
cord-299731-sis9952k	293	15	[	[	-LRB-
cord-299731-sis9952k	293	16	153	153	CD
cord-299731-sis9952k	293	17	]	]	-RRB-
cord-299731-sis9952k	293	18	,	,	,
cord-299731-sis9952k	293	19	its	-PRON-	PRP$
cord-299731-sis9952k	293	20	ability	ability	NN
cord-299731-sis9952k	293	21	to	to	TO
cord-299731-sis9952k	293	22	reach	reach	VB
cord-299731-sis9952k	293	23	the	the	DT
cord-299731-sis9952k	293	24	peripheral	peripheral	JJ
cord-299731-sis9952k	293	25	tissues	tissue	NNS
cord-299731-sis9952k	293	26	after	after	IN
cord-299731-sis9952k	293	27	oral	oral	JJ
cord-299731-sis9952k	293	28	administration	administration	NN
cord-299731-sis9952k	293	29	has	have	VBZ
cord-299731-sis9952k	293	30	been	be	VBN
cord-299731-sis9952k	293	31	compromised	compromise	VBN
cord-299731-sis9952k	293	32	[	[	-LRB-
cord-299731-sis9952k	293	33	162	162	CD
cord-299731-sis9952k	293	34	]	]	-RRB-
cord-299731-sis9952k	293	35	.	.	.
cord-299731-sis9952k	294	1	This	this	DT
cord-299731-sis9952k	294	2	limitation	limitation	NN
cord-299731-sis9952k	294	3	could	could	MD
cord-299731-sis9952k	294	4	be	be	VB
cord-299731-sis9952k	294	5	overcome	overcome	VBN
cord-299731-sis9952k	294	6	by	by	IN
cord-299731-sis9952k	294	7	the	the	DT
cord-299731-sis9952k	294	8	administration	administration	NN
cord-299731-sis9952k	294	9	of	of	IN
cord-299731-sis9952k	294	10	NRH	NRH	NNP
cord-299731-sis9952k	294	11	as	as	IN
cord-299731-sis9952k	294	12	it	-PRON-	PRP
cord-299731-sis9952k	294	13	appears	appear	VBZ
cord-299731-sis9952k	294	14	to	to	TO
cord-299731-sis9952k	294	15	be	be	VB
cord-299731-sis9952k	294	16	more	more	RBR
cord-299731-sis9952k	294	17	stable	stable	JJ
cord-299731-sis9952k	294	18	than	than	IN
cord-299731-sis9952k	294	19	NR	NR	NNP
cord-299731-sis9952k	294	20	and	and	CC
cord-299731-sis9952k	294	21	does	do	VBZ
cord-299731-sis9952k	294	22	not	not	RB
cord-299731-sis9952k	294	23	undergo	undergo	VB
cord-299731-sis9952k	294	24	direct	direct	JJ
cord-299731-sis9952k	294	25	degradation	degradation	NN
cord-299731-sis9952k	294	26	in	in	IN
cord-299731-sis9952k	294	27	plasma	plasma	NN
cord-299731-sis9952k	294	28	[	[	-LRB-
cord-299731-sis9952k	294	29	162	162	CD
cord-299731-sis9952k	294	30	]	]	-RRB-
cord-299731-sis9952k	294	31	.	.	.
cord-299731-sis9952k	295	1	NRH	NRH	NNP
cord-299731-sis9952k	295	2	is	be	VBZ
cord-299731-sis9952k	295	3	detectable	detectable	JJ
cord-299731-sis9952k	295	4	in	in	IN
cord-299731-sis9952k	295	5	circulation	circulation	NN
cord-299731-sis9952k	295	6	after	after	IN
cord-299731-sis9952k	295	7	oral	oral	JJ
cord-299731-sis9952k	295	8	intake	intake	NN
cord-299731-sis9952k	295	9	or	or	CC
cord-299731-sis9952k	295	10	intraperitoneal	intraperitoneal	JJ
cord-299731-sis9952k	295	11	injection	injection	NN
cord-299731-sis9952k	295	12	,	,	,
cord-299731-sis9952k	295	13	and	and	CC
cord-299731-sis9952k	295	14	it	-PRON-	PRP
cord-299731-sis9952k	295	15	was	be	VBD
cord-299731-sis9952k	295	16	found	find	VBN
cord-299731-sis9952k	295	17	to	to	TO
cord-299731-sis9952k	295	18	increase	increase	VB
cord-299731-sis9952k	295	19	NAD	NAD	NNP
cord-299731-sis9952k	295	20	+	+	CC
cord-299731-sis9952k	295	21	in	in	IN
cord-299731-sis9952k	295	22	both	both	DT
cord-299731-sis9952k	295	23	cultured	cultured	JJ
cord-299731-sis9952k	295	24	cells	cell	NNS
cord-299731-sis9952k	295	25	(	(	-LRB-
cord-299731-sis9952k	295	26	5	5	CD
cord-299731-sis9952k	295	27	-	-	SYM
cord-299731-sis9952k	295	28	10-fold	10-fold	JJ
cord-299731-sis9952k	295	29	above	above	IN
cord-299731-sis9952k	295	30	the	the	DT
cord-299731-sis9952k	295	31	baseline	baseline	NN
cord-299731-sis9952k	295	32	)	)	-RRB-
cord-299731-sis9952k	295	33	[	[	-LRB-
cord-299731-sis9952k	295	34	162	162	CD
cord-299731-sis9952k	295	35	,	,	,
cord-299731-sis9952k	295	36	163	163	CD
cord-299731-sis9952k	295	37	]	]	-RRB-
cord-299731-sis9952k	295	38	and	and	CC
cord-299731-sis9952k	295	39	mice	mouse	NNS
cord-299731-sis9952k	295	40	,	,	,
cord-299731-sis9952k	295	41	in	in	IN
cord-299731-sis9952k	295	42	a	a	DT
cord-299731-sis9952k	295	43	more	more	RBR
cord-299731-sis9952k	295	44	potent	potent	JJ
cord-299731-sis9952k	295	45	and	and	CC
cord-299731-sis9952k	295	46	faster	fast	JJR
cord-299731-sis9952k	295	47	manner	manner	NN
cord-299731-sis9952k	295	48	than	than	IN
cord-299731-sis9952k	295	49	NR	NR	NNP
cord-299731-sis9952k	295	50	.	.	.
cord-299731-sis9952k	296	1	Moreover	moreover	RB
cord-299731-sis9952k	296	2	,	,	,
cord-299731-sis9952k	296	3	a	a	DT
cord-299731-sis9952k	296	4	NMRK	NMRK	NNP
cord-299731-sis9952k	296	5	-	-	HYPH
cord-299731-sis9952k	296	6	independent	independent	JJ
cord-299731-sis9952k	296	7	pathway	pathway	NN
cord-299731-sis9952k	296	8	for	for	IN
cord-299731-sis9952k	296	9	the	the	DT
cord-299731-sis9952k	296	10	NRH	NRH	NNP
cord-299731-sis9952k	296	11	-	-	HYPH
cord-299731-sis9952k	296	12	induced	induce	VBN
cord-299731-sis9952k	296	13	NAD	NAD	NNP
cord-299731-sis9952k	296	14	+	+	CC
cord-299731-sis9952k	296	15	increase	increase	NN
cord-299731-sis9952k	296	16	has	have	VBZ
cord-299731-sis9952k	296	17	been	be	VBN
cord-299731-sis9952k	296	18	demonstrated	demonstrate	VBN
cord-299731-sis9952k	296	19	[	[	-LRB-
cord-299731-sis9952k	296	20	162	162	CD
cord-299731-sis9952k	296	21	]	]	-RRB-
cord-299731-sis9952k	296	22	,	,	,
cord-299731-sis9952k	296	23	which	which	WDT
cord-299731-sis9952k	296	24	is	be	VBZ
cord-299731-sis9952k	296	25	consistent	consistent	JJ
cord-299731-sis9952k	296	26	with	with	IN
cord-299731-sis9952k	296	27	a	a	DT
cord-299731-sis9952k	296	28	recent	recent	JJ
cord-299731-sis9952k	296	29	discovery	discovery	NN
cord-299731-sis9952k	296	30	of	of	IN
cord-299731-sis9952k	296	31	a	a	DT
cord-299731-sis9952k	296	32	novel	novel	JJ
cord-299731-sis9952k	296	33	biosynthetic	biosynthetic	NN
cord-299731-sis9952k	296	34	route	route	NN
cord-299731-sis9952k	296	35	of	of	IN
cord-299731-sis9952k	296	36	NAD	NAD	NNP
cord-299731-sis9952k	296	37	+	+	CC
cord-299731-sis9952k	296	38	from	from	IN
cord-299731-sis9952k	296	39	NRH	NRH	NNP
cord-299731-sis9952k	296	40	through	through	IN
cord-299731-sis9952k	296	41	the	the	DT
cord-299731-sis9952k	296	42	NMNH	NMNH	NNP
cord-299731-sis9952k	296	43	intermediate	intermediate	JJ
cord-299731-sis9952k	296	44	,	,	,
cord-299731-sis9952k	296	45	where	where	WRB
cord-299731-sis9952k	296	46	adenosine	adenosine	NN
cord-299731-sis9952k	296	47	kinase	kinase	NN
cord-299731-sis9952k	296	48	(	(	-LRB-
cord-299731-sis9952k	296	49	ADK	ADK	NNP
cord-299731-sis9952k	296	50	)	)	-RRB-
cord-299731-sis9952k	296	51	acts	act	VBZ
cord-299731-sis9952k	296	52	as	as	IN
cord-299731-sis9952k	296	53	a	a	DT
cord-299731-sis9952k	296	54	NRH	NRH	NNP
cord-299731-sis9952k	296	55	kinase	kinase	NN
cord-299731-sis9952k	296	56	[	[	-LRB-
cord-299731-sis9952k	296	57	164	164	CD
cord-299731-sis9952k	296	58	]	]	-RRB-
cord-299731-sis9952k	296	59	.	.	.
cord-299731-sis9952k	297	1	This	this	DT
cord-299731-sis9952k	297	2	study	study	NN
cord-299731-sis9952k	297	3	also	also	RB
cord-299731-sis9952k	297	4	confirmed	confirm	VBD
cord-299731-sis9952k	297	5	the	the	DT
cord-299731-sis9952k	297	6	presence	presence	NN
cord-299731-sis9952k	297	7	of	of	IN
cord-299731-sis9952k	297	8	endogenous	endogenous	JJ
cord-299731-sis9952k	297	9	NRH	nrh	NN
cord-299731-sis9952k	297	10	in	in	IN
cord-299731-sis9952k	297	11	the	the	DT
cord-299731-sis9952k	297	12	liver	liver	NN
cord-299731-sis9952k	297	13	of	of	IN
cord-299731-sis9952k	297	14	mouse	mouse	NN
cord-299731-sis9952k	297	15	models	model	NNS
cord-299731-sis9952k	297	16	establishing	establish	VBG
cord-299731-sis9952k	297	17	NRH	NRH	NNP
cord-299731-sis9952k	297	18	as	as	IN
cord-299731-sis9952k	297	19	a	a	DT
cord-299731-sis9952k	297	20	valid	valid	JJ
cord-299731-sis9952k	297	21	natural	natural	JJ
cord-299731-sis9952k	297	22	precursor	precursor	NN
cord-299731-sis9952k	297	23	of	of	IN
cord-299731-sis9952k	297	24	NAD	NAD	NNP
cord-299731-sis9952k	297	25	+	+	CC
cord-299731-sis9952k	297	26	.	.	.
cord-299731-sis9952k	298	1	On	on	IN
cord-299731-sis9952k	298	2	the	the	DT
cord-299731-sis9952k	298	3	other	other	JJ
cord-299731-sis9952k	298	4	hand	hand	NN
cord-299731-sis9952k	298	5	,	,	,
cord-299731-sis9952k	298	6	NR	NR	NNP
cord-299731-sis9952k	298	7	may	may	MD
cord-299731-sis9952k	298	8	be	be	VB
cord-299731-sis9952k	298	9	a	a	DT
cord-299731-sis9952k	298	10	more	more	RBR
cord-299731-sis9952k	298	11	suitable	suitable	JJ
cord-299731-sis9952k	298	12	NAD	NAD	NNP
cord-299731-sis9952k	298	13	+	+	CC
cord-299731-sis9952k	298	14	precursor	precursor	NN
cord-299731-sis9952k	298	15	regarding	regard	VBG
cord-299731-sis9952k	298	16	the	the	DT
cord-299731-sis9952k	298	17	side	side	NN
cord-299731-sis9952k	298	18	effects	effect	NNS
cord-299731-sis9952k	298	19	.	.	.
cord-299731-sis9952k	299	1	Although	although	IN
cord-299731-sis9952k	299	2	NA	NA	NNP
cord-299731-sis9952k	299	3	and	and	CC
cord-299731-sis9952k	299	4	NAM	NAM	NNP
cord-299731-sis9952k	299	5	can	can	MD
cord-299731-sis9952k	299	6	enter	enter	VB
cord-299731-sis9952k	299	7	the	the	DT
cord-299731-sis9952k	299	8	NAD	NAD	NNP
cord-299731-sis9952k	299	9	+	+	CC
cord-299731-sis9952k	299	10	salvage	salvage	NN
cord-299731-sis9952k	299	11	pathway	pathway	NN
cord-299731-sis9952k	299	12	,	,	,
cord-299731-sis9952k	299	13	several	several	JJ
cord-299731-sis9952k	299	14	preclinical	preclinical	JJ
cord-299731-sis9952k	299	15	studies	study	NNS
cord-299731-sis9952k	299	16	have	have	VBP
cord-299731-sis9952k	299	17	confirmed	confirm	VBN
cord-299731-sis9952k	299	18	that	that	IN
cord-299731-sis9952k	299	19	both	both	DT
cord-299731-sis9952k	299	20	NA	NA	NNP
cord-299731-sis9952k	299	21	and	and	CC
cord-299731-sis9952k	299	22	NAM	NAM	NNP
cord-299731-sis9952k	299	23	can	can	MD
cord-299731-sis9952k	299	24	cause	cause	VB
cord-299731-sis9952k	299	25	painful	painful	JJ
cord-299731-sis9952k	299	26	flushing	flushing	NN
cord-299731-sis9952k	299	27	sensations	sensation	NNS
cord-299731-sis9952k	299	28	at	at	IN
cord-299731-sis9952k	299	29	therapeutic	therapeutic	JJ
cord-299731-sis9952k	299	30	doses	dose	NNS
cord-299731-sis9952k	299	31	or	or	CC
cord-299731-sis9952k	299	32	other	other	JJ
cord-299731-sis9952k	299	33	toxic	toxic	JJ
cord-299731-sis9952k	299	34	effects	effect	NNS
cord-299731-sis9952k	299	35	[	[	-LRB-
cord-299731-sis9952k	299	36	14	14	CD
cord-299731-sis9952k	299	37	,	,	,
cord-299731-sis9952k	299	38	165	165	CD
cord-299731-sis9952k	299	39	,	,	,
cord-299731-sis9952k	299	40	166	166	CD
cord-299731-sis9952k	299	41	]	]	-RRB-
cord-299731-sis9952k	299	42	.	.	.
cord-299731-sis9952k	300	1	Although	although	IN
cord-299731-sis9952k	300	2	NMN	NMN	NNP
cord-299731-sis9952k	300	3	exhibits	exhibit	VBZ
cord-299731-sis9952k	300	4	significant	significant	JJ
cord-299731-sis9952k	300	5	beneficial	beneficial	JJ
cord-299731-sis9952k	300	6	pharmacological	pharmacological	JJ
cord-299731-sis9952k	300	7	activities	activity	NNS
cord-299731-sis9952k	300	8	in	in	IN
cord-299731-sis9952k	300	9	preclinical	preclinical	JJ
cord-299731-sis9952k	300	10	studies	study	NNS
cord-299731-sis9952k	300	11	,	,	,
cord-299731-sis9952k	300	12	there	there	EX
cord-299731-sis9952k	300	13	is	be	VBZ
cord-299731-sis9952k	300	14	still	still	RB
cord-299731-sis9952k	300	15	a	a	DT
cord-299731-sis9952k	300	16	lack	lack	NN
cord-299731-sis9952k	300	17	of	of	IN
cord-299731-sis9952k	300	18	sufficient	sufficient	JJ
cord-299731-sis9952k	300	19	clinical	clinical	JJ
cord-299731-sis9952k	300	20	and	and	CC
cord-299731-sis9952k	300	21	toxicological	toxicological	JJ
cord-299731-sis9952k	300	22	data	datum	NNS
cord-299731-sis9952k	300	23	.	.	.
cord-299731-sis9952k	301	1	To	to	IN
cord-299731-sis9952k	301	2	date	date	NN
cord-299731-sis9952k	301	3	,	,	,
cord-299731-sis9952k	301	4	there	there	EX
cord-299731-sis9952k	301	5	are	be	VBP
cord-299731-sis9952k	301	6	no	no	DT
cord-299731-sis9952k	301	7	available	available	JJ
cord-299731-sis9952k	301	8	tests	test	NNS
cord-299731-sis9952k	301	9	of	of	IN
cord-299731-sis9952k	301	10	NMN	NMN	NNP
cord-299731-sis9952k	301	11	safety	safety	NN
cord-299731-sis9952k	301	12	and	and	CC
cord-299731-sis9952k	301	13	human	human	JJ
cord-299731-sis9952k	301	14	oral	oral	JJ
cord-299731-sis9952k	301	15	availability	availability	NN
cord-299731-sis9952k	301	16	although	although	IN
cord-299731-sis9952k	301	17	recently	recently	RB
cord-299731-sis9952k	301	18	,	,	,
cord-299731-sis9952k	301	19	one	one	CD
cord-299731-sis9952k	301	20	clinical	clinical	JJ
cord-299731-sis9952k	301	21	study	study	NN
cord-299731-sis9952k	301	22	with	with	IN
cord-299731-sis9952k	301	23	ten	ten	CD
cord-299731-sis9952k	301	24	healthy	healthy	JJ
cord-299731-sis9952k	301	25	men	man	NNS
cord-299731-sis9952k	301	26	confirmed	confirm	VBD
cord-299731-sis9952k	301	27	that	that	IN
cord-299731-sis9952k	301	28	a	a	DT
cord-299731-sis9952k	301	29	single	single	JJ
cord-299731-sis9952k	301	30	oral	oral	JJ
cord-299731-sis9952k	301	31	dose	dose	NN
cord-299731-sis9952k	301	32	ranging	range	VBG
cord-299731-sis9952k	301	33	from	from	IN
cord-299731-sis9952k	301	34	100	100	CD
cord-299731-sis9952k	301	35	-	-	SYM
cord-299731-sis9952k	301	36	500	500	CD
cord-299731-sis9952k	301	37	mg	mg	NNP
cord-299731-sis9952k	301	38	is	be	VBZ
cord-299731-sis9952k	301	39	safe	safe	JJ
cord-299731-sis9952k	301	40	and	and	CC
cord-299731-sis9952k	301	41	effective	effective	JJ
cord-299731-sis9952k	301	42	,	,	,
cord-299731-sis9952k	301	43	with	with	IN
cord-299731-sis9952k	301	44	no	no	DT
cord-299731-sis9952k	301	45	significant	significant	JJ
cord-299731-sis9952k	301	46	deleterious	deleterious	JJ
cord-299731-sis9952k	301	47	effects	effect	NNS
cord-299731-sis9952k	301	48	[	[	-LRB-
cord-299731-sis9952k	301	49	167	167	CD
cord-299731-sis9952k	301	50	]	]	-RRB-
cord-299731-sis9952k	301	51	.	.	.
cord-299731-sis9952k	302	1	On	on	IN
cord-299731-sis9952k	302	2	the	the	DT
cord-299731-sis9952k	302	3	other	other	JJ
cord-299731-sis9952k	302	4	hand	hand	NN
cord-299731-sis9952k	302	5	,	,	,
cord-299731-sis9952k	302	6	NR	NR	NNP
cord-299731-sis9952k	302	7	was	be	VBD
cord-299731-sis9952k	302	8	confirmed	confirm	VBN
cord-299731-sis9952k	302	9	across	across	IN
cord-299731-sis9952k	302	10	a	a	DT
cord-299731-sis9952k	302	11	number	number	NN
cord-299731-sis9952k	302	12	of	of	IN
cord-299731-sis9952k	302	13	studies	study	NNS
cord-299731-sis9952k	302	14	as	as	RB
cord-299731-sis9952k	302	15	well	well	RB
cord-299731-sis9952k	302	16	-	-	HYPH
cord-299731-sis9952k	302	17	tolerated	tolerate	VBN
cord-299731-sis9952k	302	18	,	,	,
cord-299731-sis9952k	302	19	up	up	IN
cord-299731-sis9952k	302	20	to	to	TO
cord-299731-sis9952k	302	21	2	2	CD
cord-299731-sis9952k	302	22	g	g	NN
cord-299731-sis9952k	302	23	of	of	IN
cord-299731-sis9952k	302	24	a	a	DT
cord-299731-sis9952k	302	25	daily	daily	JJ
cord-299731-sis9952k	302	26	dose	dose	NN
cord-299731-sis9952k	302	27	,	,	,
cord-299731-sis9952k	302	28	and	and	CC
cord-299731-sis9952k	302	29	it	-PRON-	PRP
cord-299731-sis9952k	302	30	was	be	VBD
cord-299731-sis9952k	302	31	not	not	RB
cord-299731-sis9952k	302	32	found	find	VBN
cord-299731-sis9952k	302	33	to	to	TO
cord-299731-sis9952k	302	34	be	be	VB
cord-299731-sis9952k	302	35	associated	associate	VBN
cord-299731-sis9952k	302	36	with	with	IN
cord-299731-sis9952k	302	37	flushing	flushing	NN
cord-299731-sis9952k	302	38	or	or	CC
cord-299731-sis9952k	302	39	any	any	DT
cord-299731-sis9952k	302	40	severe	severe	JJ
cord-299731-sis9952k	302	41	side	side	NN
cord-299731-sis9952k	302	42	-	-	HYPH
cord-299731-sis9952k	302	43	effects	effect	NNS
cord-299731-sis9952k	302	44	[	[	-LRB-
cord-299731-sis9952k	302	45	39	39	CD
cord-299731-sis9952k	302	46	]	]	-RRB-
cord-299731-sis9952k	302	47	.	.	.
cord-299731-sis9952k	303	1	Specifically	specifically	RB
cord-299731-sis9952k	303	2	,	,	,
cord-299731-sis9952k	303	3	NR	NR	NNP
cord-299731-sis9952k	303	4	administration	administration	NN
cord-299731-sis9952k	303	5	can	can	MD
cord-299731-sis9952k	303	6	elevate	elevate	VB
cord-299731-sis9952k	303	7	NAD	NAD	NNP
cord-299731-sis9952k	303	8	+	+	CC
cord-299731-sis9952k	303	9	levels	level	NNS
cord-299731-sis9952k	303	10	in	in	IN
cord-299731-sis9952k	303	11	mammalian	mammalian	JJ
cord-299731-sis9952k	303	12	cells	cell	NNS
cord-299731-sis9952k	303	13	and	and	CC
cord-299731-sis9952k	303	14	tissues	tissue	NNS
cord-299731-sis9952k	303	15	without	without	IN
cord-299731-sis9952k	303	16	activating	activate	VBG
cord-299731-sis9952k	303	17	GPR109A	GPR109A	NNP
cord-299731-sis9952k	303	18	that	that	WDT
cord-299731-sis9952k	303	19	mediates	mediate	VBZ
cord-299731-sis9952k	303	20	nicotinic	nicotinic	JJ
cord-299731-sis9952k	303	21	acid	acid	NN
cord-299731-sis9952k	303	22	-	-	HYPH
cord-299731-sis9952k	303	23	induced	induce	VBN
cord-299731-sis9952k	303	24	flushing	flush	VBG
cord-299731-sis9952k	303	25	[	[	-LRB-
cord-299731-sis9952k	303	26	168	168	CD
cord-299731-sis9952k	303	27	]	]	-RRB-
cord-299731-sis9952k	303	28	.	.	.
cord-299731-sis9952k	304	1	During	during	IN
cord-299731-sis9952k	304	2	the	the	DT
cord-299731-sis9952k	304	3	state	state	NN
cord-299731-sis9952k	304	4	of	of	IN
cord-299731-sis9952k	304	5	physiological	physiological	JJ
cord-299731-sis9952k	304	6	equilibrium	equilibrium	NN
cord-299731-sis9952k	304	7	,	,	,
cord-299731-sis9952k	304	8	biosynthetic	biosynthetic	JJ
cord-299731-sis9952k	304	9	pathways	pathway	NNS
cord-299731-sis9952k	304	10	rely	rely	VBP
cord-299731-sis9952k	304	11	on	on	IN
cord-299731-sis9952k	304	12	dietary	dietary	JJ
cord-299731-sis9952k	304	13	sources	source	NNS
cord-299731-sis9952k	304	14	of	of	IN
cord-299731-sis9952k	304	15	tryptophan	tryptophan	NN
cord-299731-sis9952k	304	16	(	(	-LRB-
cord-299731-sis9952k	304	17	Trp	Trp	NNP
cord-299731-sis9952k	304	18	)	)	-RRB-
cord-299731-sis9952k	304	19	,	,	,
cord-299731-sis9952k	304	20	while	while	IN
cord-299731-sis9952k	304	21	NAD	NAD	NNP
cord-299731-sis9952k	304	22	+	+	CC
cord-299731-sis9952k	304	23	precursor	precursor	NN
cord-299731-sis9952k	304	24	vitamins	vitamin	NNS
cord-299731-sis9952k	304	25	are	be	VBP
cord-299731-sis9952k	304	26	compensating	compensate	VBG
cord-299731-sis9952k	304	27	during	during	IN
cord-299731-sis9952k	304	28	periods	period	NNS
cord-299731-sis9952k	304	29	of	of	IN
cord-299731-sis9952k	304	30	NAD	NAD	NNP
cord-299731-sis9952k	304	31	+	+	CC
cord-299731-sis9952k	304	32	depletion	depletion	NN
cord-299731-sis9952k	304	33	.	.	.
cord-299731-sis9952k	305	1	However	however	RB
cord-299731-sis9952k	305	2	,	,	,
cord-299731-sis9952k	305	3	dietary	dietary	JJ
cord-299731-sis9952k	305	4	precursors	precursor	NNS
cord-299731-sis9952k	305	5	may	may	MD
cord-299731-sis9952k	305	6	become	become	VB
cord-299731-sis9952k	305	7	insufficient	insufficient	JJ
cord-299731-sis9952k	305	8	to	to	TO
cord-299731-sis9952k	305	9	maintain	maintain	VB
cord-299731-sis9952k	305	10	the	the	DT
cord-299731-sis9952k	305	11	NAD	NAD	NNP
cord-299731-sis9952k	305	12	+	+	CC
cord-299731-sis9952k	305	13	levels	level	NNS
cord-299731-sis9952k	305	14	in	in	IN
cord-299731-sis9952k	305	15	pathological	pathological	JJ
cord-299731-sis9952k	305	16	conditions	condition	NNS
cord-299731-sis9952k	305	17	[	[	-LRB-
cord-299731-sis9952k	305	18	14	14	CD
cord-299731-sis9952k	305	19	,	,	,
cord-299731-sis9952k	305	20	41	41	CD
cord-299731-sis9952k	305	21	,	,	,
cord-299731-sis9952k	305	22	169	169	CD
cord-299731-sis9952k	305	23	]	]	-RRB-
cord-299731-sis9952k	305	24	,	,	,
cord-299731-sis9952k	305	25	thereby	thereby	RB
cord-299731-sis9952k	305	26	emphasizing	emphasize	VBG
cord-299731-sis9952k	305	27	the	the	DT
cord-299731-sis9952k	305	28	necessity	necessity	NN
cord-299731-sis9952k	305	29	of	of	IN
cord-299731-sis9952k	305	30	NAD	NAD	NNP
cord-299731-sis9952k	305	31	+	+	CC
cord-299731-sis9952k	305	32	precursor	precursor	NN
cord-299731-sis9952k	305	33	supplementation	supplementation	NN
cord-299731-sis9952k	305	34	.	.	.
cord-299731-sis9952k	306	1	Besides	besides	IN
cord-299731-sis9952k	306	2	the	the	DT
cord-299731-sis9952k	306	3	well	well	RB
cord-299731-sis9952k	306	4	-	-	HYPH
cord-299731-sis9952k	306	5	known	know	VBN
cord-299731-sis9952k	306	6	vitamin	vitamin	NN
cord-299731-sis9952k	306	7	B3	b3	NN
cord-299731-sis9952k	306	8	supplements	supplement	NNS
cord-299731-sis9952k	306	9	(	(	-LRB-
cord-299731-sis9952k	306	10	NA	NA	NNP
cord-299731-sis9952k	306	11	and	and	CC
cord-299731-sis9952k	306	12	NAM	NAM	NNP
cord-299731-sis9952k	306	13	)	)	-RRB-
cord-299731-sis9952k	306	14	,	,	,
cord-299731-sis9952k	306	15	NR	NR	NNP
cord-299731-sis9952k	306	16	and	and	CC
cord-299731-sis9952k	306	17	its	-PRON-	PRP$
cord-299731-sis9952k	306	18	phosphorylated	phosphorylated	JJ
cord-299731-sis9952k	306	19	form	form	NN
cord-299731-sis9952k	306	20	(	(	-LRB-
cord-299731-sis9952k	306	21	NMN	NMN	NNP
cord-299731-sis9952k	306	22	)	)	-RRB-
cord-299731-sis9952k	306	23	have	have	VBP
cord-299731-sis9952k	306	24	only	only	RB
cord-299731-sis9952k	306	25	recently	recently	RB
cord-299731-sis9952k	306	26	become	become	VBN
cord-299731-sis9952k	306	27	orally	orally	RB
cord-299731-sis9952k	306	28	available	available	JJ
cord-299731-sis9952k	306	29	as	as	IN
cord-299731-sis9952k	306	30	precursors	precursor	NNS
cord-299731-sis9952k	306	31	of	of	IN
cord-299731-sis9952k	306	32	NAD	NAD	NNP
cord-299731-sis9952k	306	33	+	+	CC
cord-299731-sis9952k	306	34	[	[	-LRB-
cord-299731-sis9952k	306	35	11	11	CD
cord-299731-sis9952k	306	36	,	,	,
cord-299731-sis9952k	306	37	150	150	CD
cord-299731-sis9952k	306	38	,	,	,
cord-299731-sis9952k	306	39	170	170	CD
cord-299731-sis9952k	306	40	,	,	,
cord-299731-sis9952k	306	41	171	171	CD
cord-299731-sis9952k	306	42	]	]	-RRB-
cord-299731-sis9952k	306	43	.	.	.
cord-299731-sis9952k	307	1	On	on	IN
cord-299731-sis9952k	307	2	the	the	DT
cord-299731-sis9952k	307	3	other	other	JJ
cord-299731-sis9952k	307	4	hand	hand	NN
cord-299731-sis9952k	307	5	,	,	,
cord-299731-sis9952k	307	6	the	the	DT
cord-299731-sis9952k	307	7	synthesis	synthesis	NN
cord-299731-sis9952k	307	8	and	and	CC
cord-299731-sis9952k	307	9	manipulation	manipulation	NN
cord-299731-sis9952k	307	10	of	of	IN
cord-299731-sis9952k	307	11	NR	NR	NNP
cord-299731-sis9952k	307	12	remain	remain	VBP
cord-299731-sis9952k	307	13	challenging	challenging	JJ
cord-299731-sis9952k	307	14	,	,	,
cord-299731-sis9952k	307	15	especially	especially	RB
cord-299731-sis9952k	307	16	regarding	regard	VBG
cord-299731-sis9952k	307	17	its	-PRON-	PRP$
cord-299731-sis9952k	307	18	relatively	relatively	RB
cord-299731-sis9952k	307	19	labile	labile	JJ
cord-299731-sis9952k	307	20	glycosidic	glycosidic	JJ
cord-299731-sis9952k	307	21	bond	bond	NN
cord-299731-sis9952k	307	22	and	and	CC
cord-299731-sis9952k	307	23	the	the	DT
cord-299731-sis9952k	307	24	instability	instability	NN
cord-299731-sis9952k	307	25	of	of	IN
cord-299731-sis9952k	307	26	NR	NR	NNP
cord-299731-sis9952k	307	27	salts	salt	NNS
cord-299731-sis9952k	307	28	[	[	-LRB-
cord-299731-sis9952k	307	29	172	172	CD
cord-299731-sis9952k	307	30	]	]	-RRB-
cord-299731-sis9952k	307	31	.	.	.
cord-299731-sis9952k	308	1	However	however	RB
cord-299731-sis9952k	308	2	,	,	,
cord-299731-sis9952k	308	3	great	great	JJ
cord-299731-sis9952k	308	4	potential	potential	NN
cord-299731-sis9952k	308	5	for	for	IN
cord-299731-sis9952k	308	6	the	the	DT
cord-299731-sis9952k	308	7	development	development	NN
cord-299731-sis9952k	308	8	of	of	IN
cord-299731-sis9952k	308	9	novel	novel	JJ
cord-299731-sis9952k	308	10	drugs	drug	NNS
cord-299731-sis9952k	308	11	and	and	CC
cord-299731-sis9952k	308	12	structural	structural	JJ
cord-299731-sis9952k	308	13	analogs	analog	NNS
cord-299731-sis9952k	308	14	of	of	IN
cord-299731-sis9952k	308	15	existing	exist	VBG
cord-299731-sis9952k	308	16	drugs	drug	NNS
cord-299731-sis9952k	308	17	can	can	MD
cord-299731-sis9952k	308	18	be	be	VB
cord-299731-sis9952k	308	19	achieved	achieve	VBN
cord-299731-sis9952k	308	20	with	with	IN
cord-299731-sis9952k	308	21	the	the	DT
cord-299731-sis9952k	308	22	introduction	introduction	NN
cord-299731-sis9952k	308	23	of	of	IN
cord-299731-sis9952k	308	24	various	various	JJ
cord-299731-sis9952k	308	25	chemical	chemical	NN
cord-299731-sis9952k	308	26	groups	group	NNS
cord-299731-sis9952k	308	27	on	on	IN
cord-299731-sis9952k	308	28	the	the	DT
cord-299731-sis9952k	308	29	backbone	backbone	NN
cord-299731-sis9952k	308	30	of	of	IN
cord-299731-sis9952k	308	31	the	the	DT
cord-299731-sis9952k	308	32	molecule	molecule	NN
cord-299731-sis9952k	308	33	[	[	-LRB-
cord-299731-sis9952k	308	34	172	172	CD
cord-299731-sis9952k	308	35	]	]	-RRB-
cord-299731-sis9952k	308	36	.	.	.
cord-299731-sis9952k	309	1	In	in	IN
cord-299731-sis9952k	309	2	general	general	JJ
cord-299731-sis9952k	309	3	,	,	,
cord-299731-sis9952k	309	4	there	there	EX
cord-299731-sis9952k	309	5	are	be	VBP
cord-299731-sis9952k	309	6	two	two	CD
cord-299731-sis9952k	309	7	reported	report	VBN
cord-299731-sis9952k	309	8	categories	category	NNS
cord-299731-sis9952k	309	9	of	of	IN
cord-299731-sis9952k	309	10	synthetic	synthetic	JJ
cord-299731-sis9952k	309	11	pathway	pathway	NN
cord-299731-sis9952k	309	12	for	for	IN
cord-299731-sis9952k	309	13	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	309	14	riboside	riboside	NN
cord-299731-sis9952k	309	15	salts	salt	NNS
cord-299731-sis9952k	309	16	(	(	-LRB-
cord-299731-sis9952k	309	17	NR	nr	NN
cord-299731-sis9952k	309	18	+	+	CC
cord-299731-sis9952k	309	19	X	x	NN
cord-299731-sis9952k	309	20	−	−	NNP
cord-299731-sis9952k	309	21	)	)	-RRB-
cord-299731-sis9952k	309	22	.	.	.
cord-299731-sis9952k	310	1	Since	since	IN
cord-299731-sis9952k	310	2	only	only	RB
cord-299731-sis9952k	310	3	the	the	DT
cord-299731-sis9952k	310	4	β	β	NN
cord-299731-sis9952k	310	5	-	-	HYPH
cord-299731-sis9952k	310	6	form	form	NN
cord-299731-sis9952k	310	7	of	of	IN
cord-299731-sis9952k	310	8	NR	nr	NN
cord-299731-sis9952k	310	9	+	+	SYM
cord-299731-sis9952k	310	10	has	have	VBZ
cord-299731-sis9952k	310	11	biochemical	biochemical	JJ
cord-299731-sis9952k	310	12	and	and	CC
cord-299731-sis9952k	310	13	medical	medical	JJ
cord-299731-sis9952k	310	14	relevance	relevance	NN
cord-299731-sis9952k	310	15	,	,	,
cord-299731-sis9952k	310	16	a	a	DT
cord-299731-sis9952k	310	17	valuable	valuable	JJ
cord-299731-sis9952k	310	18	method	method	NN
cord-299731-sis9952k	310	19	of	of	IN
cord-299731-sis9952k	310	20	NR	nr	NN
cord-299731-sis9952k	310	21	+	+	CC
cord-299731-sis9952k	310	22	synthesis	synthesis	NN
cord-299731-sis9952k	310	23	should	should	MD
cord-299731-sis9952k	310	24	provide	provide	VB
cord-299731-sis9952k	310	25	high	high	JJ
cord-299731-sis9952k	310	26	levels	level	NNS
cord-299731-sis9952k	310	27	of	of	IN
cord-299731-sis9952k	310	28	β	β	NN
cord-299731-sis9952k	310	29	-	-	HYPH
cord-299731-sis9952k	310	30	stereoselectivity	stereoselectivity	NN
cord-299731-sis9952k	310	31	.	.	.
cord-299731-sis9952k	311	1	From	from	IN
cord-299731-sis9952k	311	2	two	two	CD
cord-299731-sis9952k	311	3	main	main	JJ
cord-299731-sis9952k	311	4	synthetic	synthetic	JJ
cord-299731-sis9952k	311	5	pathways	pathway	NNS
cord-299731-sis9952k	311	6	of	of	IN
cord-299731-sis9952k	311	7	NR	NR	NNP
cord-299731-sis9952k	311	8	,	,	,
cord-299731-sis9952k	311	9	only	only	RB
cord-299731-sis9952k	311	10	one	one	CD
cord-299731-sis9952k	311	11	is	be	VBZ
cord-299731-sis9952k	311	12	predominately	predominately	RB
cord-299731-sis9952k	311	13	exploited	exploit	VBN
cord-299731-sis9952k	311	14	and	and	CC
cord-299731-sis9952k	311	15	developed	develop	VBN
cord-299731-sis9952k	311	16	in	in	IN
cord-299731-sis9952k	311	17	terms	term	NNS
cord-299731-sis9952k	311	18	of	of	IN
cord-299731-sis9952k	311	19	synthetic	synthetic	JJ
cord-299731-sis9952k	311	20	efficiency	efficiency	NN
cord-299731-sis9952k	311	21	,	,	,
cord-299731-sis9952k	311	22	stereoselectivity	stereoselectivity	NN
cord-299731-sis9952k	311	23	,	,	,
cord-299731-sis9952k	311	24	and	and	CC
cord-299731-sis9952k	311	25	overall	overall	JJ
cord-299731-sis9952k	311	26	yield	yield	NN
cord-299731-sis9952k	311	27	[	[	-LRB-
cord-299731-sis9952k	311	28	172	172	CD
cord-299731-sis9952k	311	29	]	]	-RRB-
cord-299731-sis9952k	311	30	.	.	.
cord-299731-sis9952k	312	1	This	this	DT
cord-299731-sis9952k	312	2	method	method	NN
cord-299731-sis9952k	312	3	embodies	embody	VBZ
cord-299731-sis9952k	312	4	the	the	DT
cord-299731-sis9952k	312	5	reaction	reaction	NN
cord-299731-sis9952k	312	6	between	between	IN
cord-299731-sis9952k	312	7	NAM	NAM	NNP
cord-299731-sis9952k	312	8	or	or	CC
cord-299731-sis9952k	312	9	its	-PRON-	PRP$
cord-299731-sis9952k	312	10	analogs	analog	NNS
cord-299731-sis9952k	312	11	or	or	CC
cord-299731-sis9952k	312	12	derivatives	derivative	NNS
cord-299731-sis9952k	312	13	and	and	CC
cord-299731-sis9952k	312	14	a	a	DT
cord-299731-sis9952k	312	15	peracylated	peracylated	JJ
cord-299731-sis9952k	312	16	(	(	-LRB-
cord-299731-sis9952k	312	17	halo)-d	halo)-d	NN
cord-299731-sis9952k	312	18	-	-	HYPH
cord-299731-sis9952k	312	19	ribofuranose	ribofuranose	NN
cord-299731-sis9952k	312	20	,	,	,
cord-299731-sis9952k	312	21	resulting	result	VBG
cord-299731-sis9952k	312	22	in	in	IN
cord-299731-sis9952k	312	23	the	the	DT
cord-299731-sis9952k	312	24	acylated	acylate	VBN
cord-299731-sis9952k	312	25	intermediate	intermediate	JJ
cord-299731-sis9952k	312	26	that	that	WDT
cord-299731-sis9952k	312	27	is	be	VBZ
cord-299731-sis9952k	312	28	subsequently	subsequently	RB
cord-299731-sis9952k	312	29	converted	convert	VBN
cord-299731-sis9952k	312	30	into	into	IN
cord-299731-sis9952k	312	31	the	the	DT
cord-299731-sis9952k	312	32	desired	desire	VBN
cord-299731-sis9952k	312	33	NR	nr	NN
cord-299731-sis9952k	312	34	+	+	CC
cord-299731-sis9952k	312	35	X	x	NN
cord-299731-sis9952k	312	36	−	−	NN
cord-299731-sis9952k	312	37	[	[	-LRB-
cord-299731-sis9952k	312	38	173	173	CD
cord-299731-sis9952k	312	39	,	,	,
cord-299731-sis9952k	312	40	174	174	CD
cord-299731-sis9952k	312	41	]	]	-RRB-
cord-299731-sis9952k	312	42	.	.	.
cord-299731-sis9952k	313	1	The	the	DT
cord-299731-sis9952k	313	2	synthetic	synthetic	JJ
cord-299731-sis9952k	313	3	glycosylation	glycosylation	NN
cord-299731-sis9952k	313	4	conditions	condition	NNS
cord-299731-sis9952k	313	5	depend	depend	VBP
cord-299731-sis9952k	313	6	on	on	IN
cord-299731-sis9952k	313	7	the	the	DT
cord-299731-sis9952k	313	8	nature	nature	NN
cord-299731-sis9952k	313	9	of	of	IN
cord-299731-sis9952k	313	10	the	the	DT
cord-299731-sis9952k	313	11	sugar	sugar	NN
cord-299731-sis9952k	313	12	component	component	NN
cord-299731-sis9952k	313	13	[	[	-LRB-
cord-299731-sis9952k	313	14	172	172	CD
cord-299731-sis9952k	313	15	]	]	-RRB-
cord-299731-sis9952k	313	16	.	.	.
cord-299731-sis9952k	314	1	These	these	DT
cord-299731-sis9952k	314	2	conditions	condition	NNS
cord-299731-sis9952k	314	3	differ	differ	VBP
cord-299731-sis9952k	314	4	whether	whether	IN
cord-299731-sis9952k	314	5	1-halo-2,3,5-tri	1-halo-2,3,5-tri	CD
cord-299731-sis9952k	314	6	-	-	HYPH
cord-299731-sis9952k	314	7	o	o	NN
cord-299731-sis9952k	314	8	-	-	HYPH
cord-299731-sis9952k	314	9	acylor	acylor	NN
cord-299731-sis9952k	314	10	1,2,3,5-tetra	1,2,3,5-tetra	NN
cord-299731-sis9952k	314	11	-	-	HYPH
cord-299731-sis9952k	314	12	O	o	NN
cord-299731-sis9952k	314	13	-	-	HYPH
cord-299731-sis9952k	314	14	acyl	acyl	NN
cord-299731-sis9952k	314	15	-	-	HYPH
cord-299731-sis9952k	314	16	d	d	NN
cord-299731-sis9952k	314	17	-	-	HYPH
cord-299731-sis9952k	314	18	ribofuranose	ribofuranose	NNP
cord-299731-sis9952k	314	19	is	be	VBZ
cord-299731-sis9952k	314	20	used	use	VBN
cord-299731-sis9952k	314	21	since	since	IN
cord-299731-sis9952k	314	22	fully	fully	RB
cord-299731-sis9952k	314	23	acylated	acylate	VBN
cord-299731-sis9952k	314	24	ribofuranoses	ribofuranose	NNS
cord-299731-sis9952k	314	25	require	require	VBP
cord-299731-sis9952k	314	26	the	the	DT
cord-299731-sis9952k	314	27	use	use	NN
cord-299731-sis9952k	314	28	of	of	IN
cord-299731-sis9952k	314	29	Friedel	Friedel	NNP
cord-299731-sis9952k	314	30	-	-	HYPH
cord-299731-sis9952k	314	31	Crafts	Crafts	NNP
cord-299731-sis9952k	314	32	catalysts	catalyst	NNS
cord-299731-sis9952k	314	33	that	that	WDT
cord-299731-sis9952k	314	34	need	need	VBP
cord-299731-sis9952k	314	35	to	to	TO
cord-299731-sis9952k	314	36	be	be	VB
cord-299731-sis9952k	314	37	activated	activate	VBN
cord-299731-sis9952k	314	38	as	as	IN
cord-299731-sis9952k	314	39	glycosylation	glycosylation	NN
cord-299731-sis9952k	314	40	reagents	reagent	NNS
cord-299731-sis9952k	314	41	[	[	-LRB-
cord-299731-sis9952k	314	42	172	172	CD
cord-299731-sis9952k	314	43	]	]	-RRB-
cord-299731-sis9952k	314	44	.	.	.
cord-299731-sis9952k	315	1	Furthermore	furthermore	RB
cord-299731-sis9952k	315	2	,	,	,
cord-299731-sis9952k	315	3	the	the	DT
cord-299731-sis9952k	315	4	X	x	NN
cord-299731-sis9952k	315	5	-	-	NN
cord-299731-sis9952k	315	6	ray	ray	JJ
cord-299731-sis9952k	315	7	structures	structure	NNS
cord-299731-sis9952k	315	8	of	of	IN
cord-299731-sis9952k	315	9	NR	NR	NNP
cord-299731-sis9952k	315	10	salts	salt	NNS
cord-299731-sis9952k	315	11	have	have	VBP
cord-299731-sis9952k	315	12	already	already	RB
cord-299731-sis9952k	315	13	been	be	VBN
cord-299731-sis9952k	315	14	determined	determine	VBN
cord-299731-sis9952k	315	15	.	.	.
cord-299731-sis9952k	316	1	The	the	DT
cord-299731-sis9952k	316	2	NR	NR	NNP
cord-299731-sis9952k	316	3	derivatives	derivative	NNS
cord-299731-sis9952k	316	4	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	316	5	-	-	HYPH
cord-299731-sis9952k	316	6	β	β	NN
cord-299731-sis9952k	316	7	-	-	HYPH
cord-299731-sis9952k	316	8	d	d	JJ
cord-299731-sis9952k	316	9	-	-	HYPH
cord-299731-sis9952k	316	10	riboside	riboside	JJ
cord-299731-sis9952k	316	11	chloride	chloride	NN
cord-299731-sis9952k	316	12	,	,	,
cord-299731-sis9952k	316	13	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	316	14	-	-	HYPH
cord-299731-sis9952k	316	15	β	β	NN
cord-299731-sis9952k	316	16	-	-	HYPH
cord-299731-sis9952k	316	17	d	d	JJ
cord-299731-sis9952k	316	18	-	-	HYPH
cord-299731-sis9952k	316	19	riboside	riboside	JJ
cord-299731-sis9952k	316	20	bromide	bromide	NN
cord-299731-sis9952k	316	21	,	,	,
cord-299731-sis9952k	316	22	thionicotinamide	thionicotinamide	NNP
cord-299731-sis9952k	316	23	-	-	HYPH
cord-299731-sis9952k	316	24	β	β	NN
cord-299731-sis9952k	316	25	-	-	HYPH
cord-299731-sis9952k	316	26	d	d	JJ
cord-299731-sis9952k	316	27	-	-	HYPH
cord-299731-sis9952k	316	28	riboside	riboside	JJ
cord-299731-sis9952k	316	29	bromide	bromide	NN
cord-299731-sis9952k	316	30	,	,	,
cord-299731-sis9952k	317	1	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	317	2	-	-	HYPH
cord-299731-sis9952k	317	3	β	β	NN
cord-299731-sis9952k	317	4	-	-	HYPH
cord-299731-sis9952k	317	5	d	d	JJ
cord-299731-sis9952k	317	6	-	-	HYPH
cord-299731-sis9952k	317	7	riboside	riboside	JJ
cord-299731-sis9952k	317	8	triacetate	triacetate	NN
cord-299731-sis9952k	317	9	bromide	bromide	NN
cord-299731-sis9952k	317	10	,	,	,
cord-299731-sis9952k	317	11	and	and	CC
cord-299731-sis9952k	318	1	thionicotinamide	thionicotinamide	NNP
cord-299731-sis9952k	318	2	-	-	HYPH
cord-299731-sis9952k	318	3	β	β	NN
cord-299731-sis9952k	318	4	-	-	HYPH
cord-299731-sis9952k	318	5	d	d	JJ
cord-299731-sis9952k	318	6	-	-	HYPH
cord-299731-sis9952k	318	7	riboside	riboside	JJ
cord-299731-sis9952k	318	8	triacetate	triacetate	NN
cord-299731-sis9952k	318	9	bromide	bromide	NN
cord-299731-sis9952k	318	10	were	be	VBD
cord-299731-sis9952k	318	11	successfully	successfully	RB
cord-299731-sis9952k	318	12	crystallized	crystallize	VBN
cord-299731-sis9952k	318	13	by	by	IN
cord-299731-sis9952k	318	14	the	the	DT
cord-299731-sis9952k	318	15	vapor	vapor	NN
cord-299731-sis9952k	318	16	diffusion	diffusion	NN
cord-299731-sis9952k	318	17	method	method	NN
cord-299731-sis9952k	318	18	[	[	-LRB-
cord-299731-sis9952k	318	19	175	175	CD
cord-299731-sis9952k	318	20	]	]	-RRB-
cord-299731-sis9952k	318	21	.	.	.
cord-299731-sis9952k	319	1	Moreover	moreover	RB
cord-299731-sis9952k	319	2	,	,	,
cord-299731-sis9952k	319	3	it	-PRON-	PRP
cord-299731-sis9952k	319	4	was	be	VBD
cord-299731-sis9952k	319	5	found	find	VBN
cord-299731-sis9952k	319	6	that	that	IN
cord-299731-sis9952k	319	7	a	a	DT
cord-299731-sis9952k	319	8	crystalline	crystalline	JJ
cord-299731-sis9952k	319	9	form	form	NN
cord-299731-sis9952k	319	10	of	of	IN
cord-299731-sis9952k	319	11	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	319	12	ribose	ribose	NN
cord-299731-sis9952k	319	13	chloride	chloride	NN
cord-299731-sis9952k	319	14	has	have	VBZ
cord-299731-sis9952k	319	15	advantageous	advantageous	JJ
cord-299731-sis9952k	319	16	properties	property	NNS
cord-299731-sis9952k	319	17	compared	compare	VBN
cord-299731-sis9952k	319	18	to	to	IN
cord-299731-sis9952k	319	19	amorphous	amorphous	JJ
cord-299731-sis9952k	319	20	forms	form	NNS
cord-299731-sis9952k	319	21	,	,	,
cord-299731-sis9952k	319	22	considering	consider	VBG
cord-299731-sis9952k	319	23	the	the	DT
cord-299731-sis9952k	319	24	possibilities	possibility	NNS
cord-299731-sis9952k	319	25	for	for	IN
cord-299731-sis9952k	319	26	better	well	JJR
cord-299731-sis9952k	319	27	purification	purification	NN
cord-299731-sis9952k	319	28	[	[	-LRB-
cord-299731-sis9952k	319	29	176	176	CD
cord-299731-sis9952k	319	30	]	]	-RRB-
cord-299731-sis9952k	319	31	.	.	.
cord-299731-sis9952k	320	1	However	however	RB
cord-299731-sis9952k	320	2	,	,	,
cord-299731-sis9952k	320	3	further	further	JJ
cord-299731-sis9952k	320	4	development	development	NN
cord-299731-sis9952k	320	5	of	of	IN
cord-299731-sis9952k	320	6	NR	NR	NNP
cord-299731-sis9952k	320	7	chemical	chemical	NN
cord-299731-sis9952k	320	8	synthesis	synthesis	NN
cord-299731-sis9952k	320	9	along	along	IN
cord-299731-sis9952k	320	10	with	with	IN
cord-299731-sis9952k	320	11	a	a	DT
cord-299731-sis9952k	320	12	better	well	JJR
cord-299731-sis9952k	320	13	understanding	understanding	NN
cord-299731-sis9952k	320	14	of	of	IN
cord-299731-sis9952k	320	15	the	the	DT
cord-299731-sis9952k	320	16	chemical	chemical	JJ
cord-299731-sis9952k	320	17	versatility	versatility	NN
cord-299731-sis9952k	320	18	and	and	CC
cord-299731-sis9952k	320	19	reactivity	reactivity	NN
cord-299731-sis9952k	320	20	of	of	IN
cord-299731-sis9952k	320	21	the	the	DT
cord-299731-sis9952k	320	22	ribosylated	ribosylated	JJ
cord-299731-sis9952k	320	23	forms	form	NNS
cord-299731-sis9952k	320	24	on	on	IN
cord-299731-sis9952k	320	25	the	the	DT
cord-299731-sis9952k	320	26	nicotinoyl	nicotinoyl	NNP
cord-299731-sis9952k	320	27	moiety	moiety	NN
cord-299731-sis9952k	320	28	would	would	MD
cord-299731-sis9952k	320	29	offer	offer	VB
cord-299731-sis9952k	320	30	more	more	RBR
cord-299731-sis9952k	320	31	reliable	reliable	JJ
cord-299731-sis9952k	320	32	,	,	,
cord-299731-sis9952k	320	33	more	more	RBR
cord-299731-sis9952k	320	34	scalable	scalable	JJ
cord-299731-sis9952k	320	35	,	,	,
cord-299731-sis9952k	320	36	and	and	CC
cord-299731-sis9952k	320	37	more	more	RBR
cord-299731-sis9952k	320	38	reproducible	reproducible	JJ
cord-299731-sis9952k	320	39	preparations	preparation	NNS
cord-299731-sis9952k	320	40	of	of	IN
cord-299731-sis9952k	320	41	NR	NR	NNP
cord-299731-sis9952k	320	42	+	+	CC
cord-299731-sis9952k	320	43	X	x	NN
cord-299731-sis9952k	320	44	−	−	NN
cord-299731-sis9952k	320	45	salts	salt	NNS
cord-299731-sis9952k	320	46	[	[	-LRB-
cord-299731-sis9952k	320	47	172	172	CD
cord-299731-sis9952k	320	48	]	]	-RRB-
cord-299731-sis9952k	320	49	.	.	.
cord-299731-sis9952k	321	1	In	in	IN
cord-299731-sis9952k	321	2	addition	addition	NN
cord-299731-sis9952k	321	3	,	,	,
cord-299731-sis9952k	321	4	effective	effective	JJ
cord-299731-sis9952k	321	5	modifications	modification	NNS
cord-299731-sis9952k	321	6	of	of	IN
cord-299731-sis9952k	321	7	the	the	DT
cord-299731-sis9952k	321	8	riboside	riboside	JJ
cord-299731-sis9952k	321	9	residue	residue	NN
cord-299731-sis9952k	321	10	of	of	IN
cord-299731-sis9952k	321	11	NR	NR	NNP
cord-299731-sis9952k	321	12	+	+	CC
cord-299731-sis9952k	321	13	at	at	IN
cord-299731-sis9952k	321	14	the	the	DT
cord-299731-sis9952k	321	15	5	5	CD
cord-299731-sis9952k	321	16	-hydroxy	-hydroxy	NN
cord-299731-sis9952k	321	17	position	position	NN
cord-299731-sis9952k	321	18	could	could	MD
cord-299731-sis9952k	321	19	ensure	ensure	VB
cord-299731-sis9952k	321	20	higher	high	JJR
cord-299731-sis9952k	321	21	yields	yield	NNS
cord-299731-sis9952k	321	22	,	,	,
cord-299731-sis9952k	321	23	better	well	JJR
cord-299731-sis9952k	321	24	recovery	recovery	NN
cord-299731-sis9952k	321	25	,	,	,
cord-299731-sis9952k	321	26	and	and	CC
cord-299731-sis9952k	321	27	improved	improve	VBN
cord-299731-sis9952k	321	28	purification	purification	NN
cord-299731-sis9952k	321	29	strategies	strategy	NNS
cord-299731-sis9952k	321	30	[	[	-LRB-
cord-299731-sis9952k	321	31	172	172	CD
cord-299731-sis9952k	321	32	]	]	-RRB-
cord-299731-sis9952k	321	33	.	.	.
cord-299731-sis9952k	322	1	This	this	DT
cord-299731-sis9952k	322	2	will	will	MD
cord-299731-sis9952k	322	3	enable	enable	VB
cord-299731-sis9952k	322	4	the	the	DT
cord-299731-sis9952k	322	5	improved	improved	JJ
cord-299731-sis9952k	322	6	preparation	preparation	NN
cord-299731-sis9952k	322	7	of	of	IN
cord-299731-sis9952k	322	8	new	new	JJ
cord-299731-sis9952k	322	9	pharmaceutically	pharmaceutically	RB
cord-299731-sis9952k	322	10	acceptable	acceptable	JJ
cord-299731-sis9952k	322	11	forms	form	NNS
cord-299731-sis9952k	322	12	and	and	CC
cord-299731-sis9952k	322	13	potentially	potentially	RB
cord-299731-sis9952k	322	14	therapeutically	therapeutically	RB
cord-299731-sis9952k	322	15	useful	useful	JJ
cord-299731-sis9952k	322	16	forms	form	NNS
cord-299731-sis9952k	322	17	of	of	IN
cord-299731-sis9952k	322	18	NR	nr	NN
cord-299731-sis9952k	322	19	+	+	CC
cord-299731-sis9952k	322	20	in	in	IN
cord-299731-sis9952k	322	21	addition	addition	NN
cord-299731-sis9952k	322	22	to	to	IN
cord-299731-sis9952k	322	23	the	the	DT
cord-299731-sis9952k	322	24	atom	atom	NN
cord-299731-sis9952k	322	25	-	-	HYPH
cord-299731-sis9952k	322	26	efficient	efficient	JJ
cord-299731-sis9952k	322	27	syntheses	synthesis	NNS
cord-299731-sis9952k	322	28	of	of	IN
cord-299731-sis9952k	322	29	isotopically	isotopically	RB
cord-299731-sis9952k	322	30	labeled	label	VBN
cord-299731-sis9952k	322	31	NR	nr	NN
cord-299731-sis9952k	322	32	+	+	CC
cord-299731-sis9952k	322	33	analogs	analog	NNS
cord-299731-sis9952k	322	34	and	and	CC
cord-299731-sis9952k	322	35	derivatives	derivative	NNS
cord-299731-sis9952k	322	36	[	[	-LRB-
cord-299731-sis9952k	322	37	172	172	CD
cord-299731-sis9952k	322	38	]	]	-RRB-
cord-299731-sis9952k	322	39	.	.	.
cord-299731-sis9952k	323	1	Regarding	regard	VBG
cord-299731-sis9952k	323	2	a	a	DT
cord-299731-sis9952k	323	3	high	high	JJ
cord-299731-sis9952k	323	4	demand	demand	NN
cord-299731-sis9952k	323	5	for	for	IN
cord-299731-sis9952k	323	6	NR	NR	NNP
cord-299731-sis9952k	323	7	use	use	NN
cord-299731-sis9952k	323	8	in	in	IN
cord-299731-sis9952k	323	9	studies	study	NNS
cord-299731-sis9952k	323	10	and	and	CC
cord-299731-sis9952k	323	11	for	for	IN
cord-299731-sis9952k	323	12	supplementation	supplementation	NN
cord-299731-sis9952k	323	13	,	,	,
cord-299731-sis9952k	323	14	new	new	JJ
cord-299731-sis9952k	323	15	and	and	CC
cord-299731-sis9952k	323	16	reliable	reliable	JJ
cord-299731-sis9952k	323	17	synthetic	synthetic	JJ
cord-299731-sis9952k	323	18	methods	method	NNS
cord-299731-sis9952k	323	19	for	for	IN
cord-299731-sis9952k	323	20	NR	nr	NN
cord-299731-sis9952k	323	21	production	production	NN
cord-299731-sis9952k	323	22	have	have	VBP
cord-299731-sis9952k	323	23	been	be	VBN
cord-299731-sis9952k	323	24	developed	develop	VBN
cord-299731-sis9952k	323	25	[	[	-LRB-
cord-299731-sis9952k	323	26	177	177	CD
cord-299731-sis9952k	323	27	]	]	-RRB-
cord-299731-sis9952k	323	28	during	during	IN
cord-299731-sis9952k	323	29	the	the	DT
cord-299731-sis9952k	323	30	past	past	JJ
cord-299731-sis9952k	323	31	few	few	JJ
cord-299731-sis9952k	323	32	years	year	NNS
cord-299731-sis9952k	323	33	,	,	,
cord-299731-sis9952k	323	34	enabling	enable	VBG
cord-299731-sis9952k	323	35	larger	large	JJR
cord-299731-sis9952k	323	36	quantities	quantity	NNS
cord-299731-sis9952k	323	37	available	available	JJ
cord-299731-sis9952k	323	38	for	for	IN
cord-299731-sis9952k	323	39	cell	cell	NN
cord-299731-sis9952k	323	40	-	-	HYPH
cord-299731-sis9952k	323	41	based	base	VBN
cord-299731-sis9952k	323	42	studies	study	NNS
cord-299731-sis9952k	323	43	and	and	CC
cord-299731-sis9952k	323	44	animal	animal	NN
cord-299731-sis9952k	323	45	feeding	feeding	NN
cord-299731-sis9952k	323	46	experiments	experiment	NNS
cord-299731-sis9952k	323	47	[	[	-LRB-
cord-299731-sis9952k	323	48	37	37	CD
cord-299731-sis9952k	323	49	,	,	,
cord-299731-sis9952k	323	50	88	88	CD
cord-299731-sis9952k	323	51	]	]	-RRB-
cord-299731-sis9952k	323	52	.	.	.
cord-299731-sis9952k	324	1	NR	NR	NNP
cord-299731-sis9952k	324	2	has	have	VBZ
cord-299731-sis9952k	324	3	become	become	VBN
cord-299731-sis9952k	324	4	available	available	JJ
cord-299731-sis9952k	324	5	as	as	IN
cord-299731-sis9952k	324	6	a	a	DT
cord-299731-sis9952k	324	7	supplement	supplement	NN
cord-299731-sis9952k	324	8	in	in	IN
cord-299731-sis9952k	324	9	a	a	DT
cord-299731-sis9952k	324	10	form	form	NN
cord-299731-sis9952k	324	11	of	of	IN
cord-299731-sis9952k	324	12	crystalline	crystalline	JJ
cord-299731-sis9952k	324	13	chloride	chloride	NN
cord-299731-sis9952k	324	14	salt	salt	NN
cord-299731-sis9952k	324	15	,	,	,
cord-299731-sis9952k	324	16	in	in	IN
cord-299731-sis9952k	324	17	July	July	NNP
cord-299731-sis9952k	324	18	2013	2013	CD
cord-299731-sis9952k	324	19	,	,	,
cord-299731-sis9952k	324	20	with	with	IN
cord-299731-sis9952k	324	21	the	the	DT
cord-299731-sis9952k	324	22	brand	brand	NN
cord-299731-sis9952k	324	23	name	name	NN
cord-299731-sis9952k	324	24	NIAGEN	NIAGEN	NNP
cord-299731-sis9952k	324	25	(	(	-LRB-
cord-299731-sis9952k	324	26	Chromadex	Chromadex	NNP
cord-299731-sis9952k	324	27	Inc.	Inc.	NNP
cord-299731-sis9952k	324	28	,	,	,
cord-299731-sis9952k	324	29	Irvine	Irvine	NNP
cord-299731-sis9952k	324	30	,	,	,
cord-299731-sis9952k	324	31	CA	CA	NNP
cord-299731-sis9952k	324	32	,	,	,
cord-299731-sis9952k	324	33	USA	USA	NNP
cord-299731-sis9952k	324	34	)	)	-RRB-
cord-299731-sis9952k	324	35	.	.	.
cord-299731-sis9952k	325	1	In	in	IN
cord-299731-sis9952k	325	2	a	a	DT
cord-299731-sis9952k	325	3	90-day	90-day	CD
cord-299731-sis9952k	325	4	toxicology	toxicology	NN
cord-299731-sis9952k	325	5	rat	rat	NN
cord-299731-sis9952k	325	6	study	study	NN
cord-299731-sis9952k	325	7	,	,	,
cord-299731-sis9952k	325	8	the	the	DT
cord-299731-sis9952k	325	9	crystalline	crystalline	JJ
cord-299731-sis9952k	325	10	form	form	NN
cord-299731-sis9952k	325	11	of	of	IN
cord-299731-sis9952k	325	12	NR	NR	NNP
cord-299731-sis9952k	325	13	chloride	chloride	NN
cord-299731-sis9952k	325	14	was	be	VBD
cord-299731-sis9952k	325	15	tested	test	VBN
cord-299731-sis9952k	325	16	and	and	CC
cord-299731-sis9952k	325	17	the	the	DT
cord-299731-sis9952k	325	18	lowest	low	JJS
cord-299731-sis9952k	325	19	observed	observed	JJ
cord-299731-sis9952k	325	20	adverse	adverse	JJ
cord-299731-sis9952k	325	21	effect	effect	NN
cord-299731-sis9952k	325	22	level	level	NN
cord-299731-sis9952k	325	23	(	(	-LRB-
cord-299731-sis9952k	325	24	LOAEL	LOAEL	NNP
cord-299731-sis9952k	325	25	)	)	-RRB-
cord-299731-sis9952k	325	26	was	be	VBD
cord-299731-sis9952k	325	27	1000	1000	CD
cord-299731-sis9952k	325	28	mg	mg	NNP
cord-299731-sis9952k	325	29	/	/	SYM
cord-299731-sis9952k	325	30	kg	kg	NNP
cord-299731-sis9952k	325	31	/	/	SYM
cord-299731-sis9952k	325	32	day	day	NN
cord-299731-sis9952k	325	33	,	,	,
cord-299731-sis9952k	325	34	whereas	whereas	IN
cord-299731-sis9952k	325	35	the	the	DT
cord-299731-sis9952k	325	36	no	no	DT
cord-299731-sis9952k	325	37	observed	observed	JJ
cord-299731-sis9952k	325	38	adverse	adverse	JJ
cord-299731-sis9952k	325	39	effect	effect	NN
cord-299731-sis9952k	325	40	level	level	NN
cord-299731-sis9952k	325	41	(	(	-LRB-
cord-299731-sis9952k	325	42	NOAEL	NOAEL	NNP
cord-299731-sis9952k	325	43	)	)	-RRB-
cord-299731-sis9952k	325	44	was	be	VBD
cord-299731-sis9952k	325	45	300	300	CD
cord-299731-sis9952k	325	46	mg	mg	NNP
cord-299731-sis9952k	325	47	/	/	SYM
cord-299731-sis9952k	325	48	kg	kg	NNP
cord-299731-sis9952k	325	49	/	/	SYM
cord-299731-sis9952k	325	50	day	day	NN
cord-299731-sis9952k	325	51	[	[	-LRB-
cord-299731-sis9952k	325	52	178	178	CD
cord-299731-sis9952k	325	53	]	]	-RRB-
cord-299731-sis9952k	325	54	.	.	.
cord-299731-sis9952k	326	1	NR	NR	NNP
cord-299731-sis9952k	326	2	has	have	VBZ
cord-299731-sis9952k	326	3	also	also	RB
cord-299731-sis9952k	326	4	been	be	VBN
cord-299731-sis9952k	326	5	tested	test	VBN
cord-299731-sis9952k	326	6	in	in	IN
cord-299731-sis9952k	326	7	six	six	CD
cord-299731-sis9952k	326	8	clinical	clinical	JJ
cord-299731-sis9952k	326	9	trials	trial	NNS
cord-299731-sis9952k	326	10	[	[	-LRB-
cord-299731-sis9952k	326	11	39	39	CD
cord-299731-sis9952k	326	12	,	,	,
cord-299731-sis9952k	326	13	43	43	CD
cord-299731-sis9952k	326	14	,	,	,
cord-299731-sis9952k	326	15	149	149	CD
cord-299731-sis9952k	326	16	,	,	,
cord-299731-sis9952k	326	17	150	150	CD
cord-299731-sis9952k	326	18	,	,	,
cord-299731-sis9952k	326	19	179	179	CD
cord-299731-sis9952k	326	20	,	,	,
cord-299731-sis9952k	326	21	180	180	CD
cord-299731-sis9952k	326	22	]	]	-RRB-
cord-299731-sis9952k	326	23	,	,	,
cord-299731-sis9952k	326	24	where	where	WRB
cord-299731-sis9952k	326	25	NR	NR	NNP
cord-299731-sis9952k	326	26	was	be	VBD
cord-299731-sis9952k	326	27	established	establish	VBN
cord-299731-sis9952k	326	28	as	as	RB
cord-299731-sis9952k	326	29	safe	safe	JJ
cord-299731-sis9952k	326	30	for	for	IN
cord-299731-sis9952k	326	31	short	short	JJ
cord-299731-sis9952k	326	32	(	(	-LRB-
cord-299731-sis9952k	326	33	8	8	CD
cord-299731-sis9952k	326	34	days	day	NNS
cord-299731-sis9952k	326	35	)	)	-RRB-
cord-299731-sis9952k	326	36	[	[	-LRB-
cord-299731-sis9952k	326	37	150	150	CD
cord-299731-sis9952k	326	38	]	]	-RRB-
cord-299731-sis9952k	326	39	and	and	CC
cord-299731-sis9952k	326	40	long	long	JJ
cord-299731-sis9952k	326	41	-	-	HYPH
cord-299731-sis9952k	326	42	term	term	NN
cord-299731-sis9952k	326	43	(	(	-LRB-
cord-299731-sis9952k	326	44	6	6	CD
cord-299731-sis9952k	326	45	weeks	week	NNS
cord-299731-sis9952k	326	46	)	)	-RRB-
cord-299731-sis9952k	326	47	[	[	-LRB-
cord-299731-sis9952k	326	48	39	39	CD
cord-299731-sis9952k	326	49	,	,	,
cord-299731-sis9952k	326	50	179	179	CD
cord-299731-sis9952k	326	51	]	]	-RRB-
cord-299731-sis9952k	326	52	use	use	VBP
cord-299731-sis9952k	326	53	along	along	IN
cord-299731-sis9952k	326	54	with	with	IN
cord-299731-sis9952k	326	55	confirmed	confirm	VBN
cord-299731-sis9952k	326	56	oral	oral	JJ
cord-299731-sis9952k	326	57	availability	availability	NN
cord-299731-sis9952k	326	58	[	[	-LRB-
cord-299731-sis9952k	326	59	149	149	CD
cord-299731-sis9952k	326	60	]	]	-RRB-
cord-299731-sis9952k	326	61	.	.	.
cord-299731-sis9952k	327	1	Furthermore	furthermore	RB
cord-299731-sis9952k	327	2	,	,	,
cord-299731-sis9952k	327	3	a	a	DT
cord-299731-sis9952k	327	4	randomized	randomized	JJ
cord-299731-sis9952k	327	5	8-week	8-week	CD
cord-299731-sis9952k	327	6	placebo	placebo	NN
cord-299731-sis9952k	327	7	-	-	HYPH
cord-299731-sis9952k	327	8	controlled	control	VBN
cord-299731-sis9952k	327	9	trial	trial	NN
cord-299731-sis9952k	327	10	with	with	IN
cord-299731-sis9952k	327	11	three	three	CD
cord-299731-sis9952k	327	12	different	different	JJ
cord-299731-sis9952k	327	13	doses	dose	NNS
cord-299731-sis9952k	327	14	(	(	-LRB-
cord-299731-sis9952k	327	15	up	up	IN
cord-299731-sis9952k	327	16	to	to	TO
cord-299731-sis9952k	327	17	1	1	CD
cord-299731-sis9952k	327	18	g	g	NN
cord-299731-sis9952k	327	19	)	)	-RRB-
cord-299731-sis9952k	327	20	of	of	IN
cord-299731-sis9952k	327	21	NR	NR	NNP
cord-299731-sis9952k	327	22	,	,	,
cord-299731-sis9952k	327	23	tested	test	VBN
cord-299731-sis9952k	327	24	in	in	IN
cord-299731-sis9952k	327	25	overweight	overweight	JJ
cord-299731-sis9952k	327	26	and	and	CC
cord-299731-sis9952k	327	27	healthy	healthy	JJ
cord-299731-sis9952k	327	28	adults	adult	NNS
cord-299731-sis9952k	327	29	,	,	,
cord-299731-sis9952k	327	30	reported	report	VBD
cord-299731-sis9952k	327	31	that	that	IN
cord-299731-sis9952k	327	32	NR	NR	NNP
cord-299731-sis9952k	327	33	chloride	chloride	NN
cord-299731-sis9952k	327	34	is	be	VBZ
cord-299731-sis9952k	327	35	safe	safe	JJ
cord-299731-sis9952k	327	36	and	and	CC
cord-299731-sis9952k	327	37	orally	orally	RB
cord-299731-sis9952k	327	38	available	available	JJ
cord-299731-sis9952k	327	39	[	[	-LRB-
cord-299731-sis9952k	327	40	178	178	CD
cord-299731-sis9952k	327	41	]	]	-RRB-
cord-299731-sis9952k	327	42	.	.	.
cord-299731-sis9952k	328	1	Remarkable	remarkable	JJ
cord-299731-sis9952k	328	2	discoveries	discovery	NNS
cord-299731-sis9952k	328	3	regarding	regard	VBG
cord-299731-sis9952k	328	4	numerous	numerous	JJ
cord-299731-sis9952k	328	5	beneficial	beneficial	JJ
cord-299731-sis9952k	328	6	health	health	NN
cord-299731-sis9952k	328	7	effects	effect	NNS
cord-299731-sis9952k	328	8	of	of	IN
cord-299731-sis9952k	328	9	NR	nr	NN
cord-299731-sis9952k	328	10	in	in	IN
cord-299731-sis9952k	328	11	preclinical	preclinical	JJ
cord-299731-sis9952k	328	12	studies	study	NNS
cord-299731-sis9952k	328	13	might	may	MD
cord-299731-sis9952k	328	14	finally	finally	RB
cord-299731-sis9952k	328	15	culminate	culminate	VB
cord-299731-sis9952k	328	16	in	in	IN
cord-299731-sis9952k	328	17	a	a	DT
cord-299731-sis9952k	328	18	breakthrough	breakthrough	NN
cord-299731-sis9952k	328	19	,	,	,
cord-299731-sis9952k	328	20	and	and	CC
cord-299731-sis9952k	328	21	enable	enable	VB
cord-299731-sis9952k	328	22	treatment	treatment	NN
cord-299731-sis9952k	328	23	of	of	IN
cord-299731-sis9952k	328	24	a	a	DT
cord-299731-sis9952k	328	25	large	large	JJ
cord-299731-sis9952k	328	26	number	number	NN
cord-299731-sis9952k	328	27	of	of	IN
cord-299731-sis9952k	328	28	metabolic	metabolic	JJ
cord-299731-sis9952k	328	29	and	and	CC
cord-299731-sis9952k	328	30	neurodegenerative	neurodegenerative	JJ
cord-299731-sis9952k	328	31	disorders	disorder	NNS
cord-299731-sis9952k	328	32	.	.	.
cord-299731-sis9952k	329	1	NR	NR	NNP
cord-299731-sis9952k	329	2	effects	effect	NNS
cord-299731-sis9952k	329	3	are	be	VBP
cord-299731-sis9952k	329	4	currently	currently	RB
cord-299731-sis9952k	329	5	being	be	VBG
cord-299731-sis9952k	329	6	investigated	investigate	VBN
cord-299731-sis9952k	329	7	in	in	IN
cord-299731-sis9952k	329	8	a	a	DT
cord-299731-sis9952k	329	9	significant	significant	JJ
cord-299731-sis9952k	329	10	number	number	NN
cord-299731-sis9952k	329	11	of	of	IN
cord-299731-sis9952k	329	12	clinical	clinical	JJ
cord-299731-sis9952k	329	13	trials	trial	NNS
cord-299731-sis9952k	329	14	[	[	-LRB-
cord-299731-sis9952k	329	15	181	181	CD
cord-299731-sis9952k	329	16	]	]	-RRB-
cord-299731-sis9952k	329	17	,	,	,
cord-299731-sis9952k	329	18	including	include	VBG
cord-299731-sis9952k	329	19	research	research	NN
cord-299731-sis9952k	329	20	into	into	IN
cord-299731-sis9952k	329	21	diverse	diverse	JJ
cord-299731-sis9952k	329	22	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	329	23	diseases	disease	NNS
cord-299731-sis9952k	329	24	,	,	,
cord-299731-sis9952k	329	25	neural	neural	JJ
cord-299731-sis9952k	329	26	and	and	CC
cord-299731-sis9952k	329	27	cognitive	cognitive	JJ
cord-299731-sis9952k	329	28	functions	function	NNS
cord-299731-sis9952k	329	29	,	,	,
cord-299731-sis9952k	329	30	metabolic	metabolic	JJ
cord-299731-sis9952k	329	31	disturbances	disturbance	NNS
cord-299731-sis9952k	329	32	,	,	,
cord-299731-sis9952k	329	33	muscular	muscular	JJ
cord-299731-sis9952k	329	34	and	and	CC
cord-299731-sis9952k	329	35	kidney	kidney	NN
cord-299731-sis9952k	329	36	injuries	injury	NNS
cord-299731-sis9952k	329	37	,	,	,
cord-299731-sis9952k	329	38	aging	age	VBG
cord-299731-sis9952k	329	39	,	,	,
cord-299731-sis9952k	329	40	chemotherapy	chemotherapy	NN
cord-299731-sis9952k	329	41	.	.	.
cord-299731-sis9952k	330	1	In	in	IN
cord-299731-sis9952k	330	2	addition	addition	NN
cord-299731-sis9952k	330	3	,	,	,
cord-299731-sis9952k	330	4	fundamental	fundamental	JJ
cord-299731-sis9952k	330	5	research	research	NN
cord-299731-sis9952k	330	6	on	on	IN
cord-299731-sis9952k	330	7	NR	NR	NNP
cord-299731-sis9952k	330	8	transport	transport	NN
cord-299731-sis9952k	330	9	and	and	CC
cord-299731-sis9952k	330	10	metabolic	metabolic	JJ
cord-299731-sis9952k	330	11	pathways	pathway	NNS
cord-299731-sis9952k	330	12	will	will	MD
cord-299731-sis9952k	330	13	further	further	RB
cord-299731-sis9952k	330	14	support	support	VB
cord-299731-sis9952k	330	15	a	a	DT
cord-299731-sis9952k	330	16	rapid	rapid	JJ
cord-299731-sis9952k	330	17	translation	translation	NN
cord-299731-sis9952k	330	18	to	to	IN
cord-299731-sis9952k	330	19	effective	effective	JJ
cord-299731-sis9952k	330	20	therapeutic	therapeutic	JJ
cord-299731-sis9952k	330	21	use	use	NN
cord-299731-sis9952k	330	22	.	.	.
cord-299731-sis9952k	331	1	The	the	DT
cord-299731-sis9952k	331	2	advantages	advantage	NNS
cord-299731-sis9952k	331	3	of	of	IN
cord-299731-sis9952k	331	4	using	use	VBG
cord-299731-sis9952k	331	5	NR	NR	NNP
cord-299731-sis9952k	331	6	over	over	IN
cord-299731-sis9952k	331	7	alternative	alternative	JJ
cord-299731-sis9952k	331	8	NAD	NAD	NNP
cord-299731-sis9952k	331	9	+	+	CC
cord-299731-sis9952k	331	10	precursors	precursor	NNS
cord-299731-sis9952k	331	11	,	,	,
cord-299731-sis9952k	331	12	including	include	VBG
cord-299731-sis9952k	331	13	its	-PRON-	PRP$
cord-299731-sis9952k	331	14	safety	safety	NN
cord-299731-sis9952k	331	15	and	and	CC
cord-299731-sis9952k	331	16	efficiency	efficiency	NN
cord-299731-sis9952k	331	17	,	,	,
cord-299731-sis9952k	331	18	suggest	suggest	VBP
cord-299731-sis9952k	331	19	the	the	DT
cord-299731-sis9952k	331	20	possible	possible	JJ
cord-299731-sis9952k	331	21	replacement	replacement	NN
cord-299731-sis9952k	331	22	of	of	IN
cord-299731-sis9952k	331	23	niacin	niacin	NN
cord-299731-sis9952k	331	24	as	as	IN
cord-299731-sis9952k	331	25	a	a	DT
cord-299731-sis9952k	331	26	general	general	JJ
cord-299731-sis9952k	331	27	supplement	supplement	NN
cord-299731-sis9952k	331	28	in	in	IN
cord-299731-sis9952k	331	29	the	the	DT
cord-299731-sis9952k	331	30	near	near	JJ
cord-299731-sis9952k	331	31	future	future	NN
cord-299731-sis9952k	331	32	.	.	.
cord-299731-sis9952k	332	1	However	however	RB
cord-299731-sis9952k	332	2	,	,	,
cord-299731-sis9952k	332	3	the	the	DT
cord-299731-sis9952k	332	4	use	use	NN
cord-299731-sis9952k	332	5	of	of	IN
cord-299731-sis9952k	332	6	NR	NR	NNP
cord-299731-sis9952k	332	7	as	as	IN
cord-299731-sis9952k	332	8	a	a	DT
cord-299731-sis9952k	332	9	nutritional	nutritional	JJ
cord-299731-sis9952k	332	10	supplement	supplement	NN
cord-299731-sis9952k	332	11	still	still	RB
cord-299731-sis9952k	332	12	has	have	VBZ
cord-299731-sis9952k	332	13	certain	certain	JJ
cord-299731-sis9952k	332	14	limitations	limitation	NNS
cord-299731-sis9952k	332	15	with	with	IN
cord-299731-sis9952k	332	16	respect	respect	NN
cord-299731-sis9952k	332	17	to	to	IN
cord-299731-sis9952k	332	18	its	-PRON-	PRP$
cord-299731-sis9952k	332	19	production	production	NN
cord-299731-sis9952k	332	20	methods	method	NNS
cord-299731-sis9952k	332	21	,	,	,
cord-299731-sis9952k	332	22	including	include	VBG
cord-299731-sis9952k	332	23	low	low	JJ
cord-299731-sis9952k	332	24	yield	yield	NN
cord-299731-sis9952k	332	25	,	,	,
cord-299731-sis9952k	332	26	the	the	DT
cord-299731-sis9952k	332	27	use	use	NN
cord-299731-sis9952k	332	28	of	of	IN
cord-299731-sis9952k	332	29	expensive	expensive	JJ
cord-299731-sis9952k	332	30	or	or	CC
cord-299731-sis9952k	332	31	hazardous	hazardous	JJ
cord-299731-sis9952k	332	32	reagents	reagent	NNS
cord-299731-sis9952k	332	33	,	,	,
cord-299731-sis9952k	332	34	and	and	CC
cord-299731-sis9952k	332	35	pharmaceutically	pharmaceutically	RB
cord-299731-sis9952k	332	36	unacceptable	unacceptable	JJ
cord-299731-sis9952k	332	37	species	specie	NNS
cord-299731-sis9952k	332	38	that	that	WDT
cord-299731-sis9952k	332	39	may	may	MD
cord-299731-sis9952k	332	40	be	be	VB
cord-299731-sis9952k	332	41	toxic	toxic	JJ
cord-299731-sis9952k	332	42	or	or	CC
cord-299731-sis9952k	332	43	biologically	biologically	RB
cord-299731-sis9952k	332	44	intolerable	intolerable	JJ
cord-299731-sis9952k	332	45	by	by	IN
cord-299731-sis9952k	332	46	other	other	JJ
cord-299731-sis9952k	332	47	means	mean	NNS
cord-299731-sis9952k	332	48	.	.	.
cord-299731-sis9952k	333	1	With	with	IN
cord-299731-sis9952k	333	2	the	the	DT
cord-299731-sis9952k	333	3	rising	rise	VBG
cord-299731-sis9952k	333	4	number	number	NN
cord-299731-sis9952k	333	5	of	of	IN
cord-299731-sis9952k	333	6	patents	patent	NNS
cord-299731-sis9952k	333	7	,	,	,
cord-299731-sis9952k	333	8	these	these	DT
cord-299731-sis9952k	333	9	limitations	limitation	NNS
cord-299731-sis9952k	333	10	are	be	VBP
cord-299731-sis9952k	333	11	being	be	VBG
cord-299731-sis9952k	333	12	overcome	overcome	VBN
cord-299731-sis9952k	333	13	with	with	IN
cord-299731-sis9952k	333	14	the	the	DT
cord-299731-sis9952k	333	15	development	development	NN
cord-299731-sis9952k	333	16	of	of	IN
cord-299731-sis9952k	333	17	new	new	JJ
cord-299731-sis9952k	333	18	or	or	CC
cord-299731-sis9952k	333	19	improved	improved	JJ
cord-299731-sis9952k	333	20	methods	method	NNS
cord-299731-sis9952k	333	21	for	for	IN
cord-299731-sis9952k	333	22	chemical	chemical	JJ
cord-299731-sis9952k	333	23	synthesis	synthesis	NN
cord-299731-sis9952k	333	24	of	of	IN
cord-299731-sis9952k	333	25	NR	NR	NNP
cord-299731-sis9952k	333	26	and	and	CC
cord-299731-sis9952k	333	27	its	-PRON-	PRP$
cord-299731-sis9952k	333	28	derivatives	derivative	NNS
cord-299731-sis9952k	333	29	.	.	.
cord-299731-sis9952k	334	1	This	this	DT
cord-299731-sis9952k	334	2	will	will	MD
cord-299731-sis9952k	334	3	enable	enable	VB
cord-299731-sis9952k	334	4	robust	robust	JJ
cord-299731-sis9952k	334	5	,	,	,
cord-299731-sis9952k	334	6	cost	cost	NN
cord-299731-sis9952k	334	7	-	-	HYPH
cord-299731-sis9952k	334	8	effective	effective	JJ
cord-299731-sis9952k	334	9	production	production	NN
cord-299731-sis9952k	334	10	with	with	IN
cord-299731-sis9952k	334	11	higher	high	JJR
cord-299731-sis9952k	334	12	purity	purity	NN
cord-299731-sis9952k	334	13	and	and	CC
cord-299731-sis9952k	334	14	stereoselectivity	stereoselectivity	NN
cord-299731-sis9952k	334	15	.	.	.
cord-299731-sis9952k	335	1	Extensive	extensive	JJ
cord-299731-sis9952k	335	2	research	research	NN
cord-299731-sis9952k	335	3	into	into	IN
cord-299731-sis9952k	335	4	NR	NR	NNP
cord-299731-sis9952k	335	5	might	may	MD
cord-299731-sis9952k	335	6	also	also	RB
cord-299731-sis9952k	335	7	lead	lead	VB
cord-299731-sis9952k	335	8	to	to	IN
cord-299731-sis9952k	335	9	its	-PRON-	PRP$
cord-299731-sis9952k	335	10	global	global	JJ
cord-299731-sis9952k	335	11	availability	availability	NN
cord-299731-sis9952k	335	12	in	in	IN
cord-299731-sis9952k	335	13	supplementation	supplementation	NN
cord-299731-sis9952k	335	14	use	use	NN
cord-299731-sis9952k	335	15	and	and	CC
cord-299731-sis9952k	335	16	novel	novel	JJ
cord-299731-sis9952k	335	17	therapeutic	therapeutic	JJ
cord-299731-sis9952k	335	18	strategies	strategy	NNS
cord-299731-sis9952k	335	19	,	,	,
cord-299731-sis9952k	335	20	most	most	RBS
cord-299731-sis9952k	335	21	importantly	importantly	RB
cord-299731-sis9952k	335	22	for	for	IN
cord-299731-sis9952k	335	23	pathophysiological	pathophysiological	JJ
cord-299731-sis9952k	335	24	conditions	condition	NNS
cord-299731-sis9952k	335	25	that	that	WDT
cord-299731-sis9952k	335	26	currently	currently	RB
cord-299731-sis9952k	335	27	lack	lack	VBP
cord-299731-sis9952k	335	28	efficient	efficient	JJ
cord-299731-sis9952k	335	29	treatment	treatment	NN
cord-299731-sis9952k	335	30	.	.	.
cord-299731-sis9952k	336	1	Funding	funding	NN
cord-299731-sis9952k	336	2	:	:	:
cord-299731-sis9952k	337	1	This	this	DT
cord-299731-sis9952k	337	2	research	research	NN
cord-299731-sis9952k	337	3	received	receive	VBD
cord-299731-sis9952k	337	4	no	no	DT
cord-299731-sis9952k	337	5	external	external	JJ
cord-299731-sis9952k	337	6	funding	funding	NN
cord-299731-sis9952k	337	7	.	.	.
cord-299731-sis9952k	338	1	The	the	DT
cord-299731-sis9952k	338	2	authors	author	NNS
cord-299731-sis9952k	338	3	declare	declare	VBP
cord-299731-sis9952k	338	4	the	the	DT
cord-299731-sis9952k	338	5	following	follow	VBG
cord-299731-sis9952k	338	6	competing	compete	VBG
cord-299731-sis9952k	338	7	financial	financial	JJ
cord-299731-sis9952k	338	8	interest(s	interest(s	NN
cord-299731-sis9952k	338	9	)	)	-RRB-
cord-299731-sis9952k	338	10	:	:	:
cord-299731-sis9952k	338	11	M.M	M.M	NNP
cord-299731-sis9952k	338	12	and	and	CC
cord-299731-sis9952k	338	13	U.S.	U.S.	NNP
cord-299731-sis9952k	338	14	are	be	VBP
cord-299731-sis9952k	338	15	employees	employee	NNS
cord-299731-sis9952k	338	16	of	of	IN
cord-299731-sis9952k	338	17	the	the	DT
cord-299731-sis9952k	338	18	Biosynth	Biosynth	NNP
cord-299731-sis9952k	338	19	Carbosynth	Carbosynth	NNP
cord-299731-sis9952k	338	20	group	group	NN
cord-299731-sis9952k	338	21	,	,	,
cord-299731-sis9952k	338	22	a	a	DT
cord-299731-sis9952k	338	23	corporation	corporation	NN
cord-299731-sis9952k	338	24	that	that	WDT
cord-299731-sis9952k	338	25	sells	sell	VBZ
cord-299731-sis9952k	338	26	various	various	JJ
cord-299731-sis9952k	338	27	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	338	28	riboside	riboside	NN
cord-299731-sis9952k	338	29	derivatives	derivative	NNS
cord-299731-sis9952k	338	30	.	.	.
cord-299731-sis9952k	339	1	U.S.	U.S.	NNP
cord-299731-sis9952k	339	2	acknowledges	acknowledge	VBZ
cord-299731-sis9952k	339	3	that	that	IN
cord-299731-sis9952k	339	4	he	-PRON-	PRP
cord-299731-sis9952k	339	5	has	have	VBZ
cord-299731-sis9952k	339	6	intellectual	intellectual	JJ
cord-299731-sis9952k	339	7	property	property	NN
cord-299731-sis9952k	339	8	related	relate	VBN
cord-299731-sis9952k	339	9	to	to	IN
cord-299731-sis9952k	339	10	methods	method	NNS
cord-299731-sis9952k	339	11	to	to	TO
cord-299731-sis9952k	339	12	produce	produce	VB
cord-299731-sis9952k	339	13	NR	NR	NNP
cord-299731-sis9952k	339	14	salts	salt	NNS
cord-299731-sis9952k	339	15	and	and	CC
cord-299731-sis9952k	339	16	possible	possible	JJ
cord-299731-sis9952k	339	17	uses	use	NNS
cord-299731-sis9952k	339	18	thereof	thereof	RB
cord-299731-sis9952k	339	19	.	.	.
cord-299731-sis9952k	340	1	Royalties	royalty	NNS
cord-299731-sis9952k	340	2	on	on	IN
cord-299731-sis9952k	340	3	sales	sale	NNS
cord-299731-sis9952k	340	4	of	of	IN
cord-299731-sis9952k	340	5	NR	NR	NNP
cord-299731-sis9952k	340	6	are	be	VBP
cord-299731-sis9952k	340	7	expected	expect	VBN
cord-299731-sis9952k	340	8	to	to	TO
cord-299731-sis9952k	340	9	accrue	accrue	VB
cord-299731-sis9952k	340	10	to	to	IN
cord-299731-sis9952k	340	11	U.S.	U.S.	NNP
cord-299731-sis9952k	340	12	as	as	IN
cord-299731-sis9952k	340	13	inventor	inventor	NN
cord-299731-sis9952k	340	14	.	.	.
cord-299731-sis9952k	341	1	No	no	DT
cord-299731-sis9952k	341	2	further	further	JJ
cord-299731-sis9952k	341	3	conflicts	conflict	NNS
cord-299731-sis9952k	341	4	of	of	IN
cord-299731-sis9952k	341	5	interest	interest	NN
cord-299731-sis9952k	341	6	are	be	VBP
cord-299731-sis9952k	341	7	declared	declare	VBN
cord-299731-sis9952k	341	8	.	.	.
cord-299731-sis9952k	342	1	NAD+	NAD+	NNP
cord-299731-sis9952k	342	2	Metabolism	Metabolism	NNP
cord-299731-sis9952k	342	3	and	and	CC
cord-299731-sis9952k	342	4	the	the	DT
cord-299731-sis9952k	342	5	Control	Control	NNP
cord-299731-sis9952k	342	6	of	of	IN
cord-299731-sis9952k	342	7	Energy	Energy	NNP
cord-299731-sis9952k	342	8	Homeostasis	Homeostasis	NNP
cord-299731-sis9952k	342	9	:	:	:
cord-299731-sis9952k	343	1	A	a	DT
cord-299731-sis9952k	343	2	Balancing	Balancing	NNP
cord-299731-sis9952k	343	3	Act	Act	NNP
cord-299731-sis9952k	343	4	between	between	IN
cord-299731-sis9952k	343	5	Mitochondria	Mitochondria	NNP
cord-299731-sis9952k	343	6	and	and	CC
cord-299731-sis9952k	343	7	the	the	DT
cord-299731-sis9952k	343	8	Nucleus	Nucleus	NNP
cord-299731-sis9952k	343	9	NAD+	NAD+	NNP
cord-299731-sis9952k	343	10	and	and	CC
cord-299731-sis9952k	343	11	sirtuins	sirtuin	NNS
cord-299731-sis9952k	343	12	in	in	IN
cord-299731-sis9952k	343	13	aging	aging	NN
cord-299731-sis9952k	343	14	and	and	CC
cord-299731-sis9952k	343	15	disease	disease	NN
cord-299731-sis9952k	343	16	NAD+	NAD+	NNP
cord-299731-sis9952k	343	17	in	in	IN
cord-299731-sis9952k	343	18	aging	age	VBG
cord-299731-sis9952k	343	19	,	,	,
cord-299731-sis9952k	343	20	metabolism	metabolism	NN
cord-299731-sis9952k	343	21	,	,	,
cord-299731-sis9952k	343	22	and	and	CC
cord-299731-sis9952k	343	23	neurodegeneration	neurodegeneration	NN
cord-299731-sis9952k	344	1	The	the	DT
cord-299731-sis9952k	344	2	importance	importance	NN
cord-299731-sis9952k	344	3	of	of	IN
cord-299731-sis9952k	344	4	NAMPT	NAMPT	NNP
cord-299731-sis9952k	344	5	/	/	SYM
cord-299731-sis9952k	344	6	NAD	NAD	NNP
cord-299731-sis9952k	344	7	/	/	,
cord-299731-sis9952k	344	8	SIRT1	sirt1	XX
cord-299731-sis9952k	344	9	in	in	IN
cord-299731-sis9952k	344	10	the	the	DT
cord-299731-sis9952k	344	11	systemic	systemic	JJ
cord-299731-sis9952k	344	12	regulation	regulation	NN
cord-299731-sis9952k	344	13	of	of	IN
cord-299731-sis9952k	344	14	metabolism	metabolism	NN
cord-299731-sis9952k	344	15	and	and	CC
cord-299731-sis9952k	344	16	ageing	age	VBG
cord-299731-sis9952k	344	17	The	the	DT
cord-299731-sis9952k	344	18	many	many	JJ
cord-299731-sis9952k	344	19	faces	face	NNS
cord-299731-sis9952k	344	20	of	of	IN
cord-299731-sis9952k	344	21	sirtuins	sirtuin	NNS
cord-299731-sis9952k	344	22	:	:	:
cord-299731-sis9952k	344	23	Coupling	coupling	NN
cord-299731-sis9952k	344	24	of	of	IN
cord-299731-sis9952k	344	25	NAD	NAD	NNP
cord-299731-sis9952k	344	26	metabolism	metabolism	NN
cord-299731-sis9952k	344	27	,	,	,
cord-299731-sis9952k	344	28	sirtuins	sirtuin	NNS
cord-299731-sis9952k	344	29	and	and	CC
cord-299731-sis9952k	344	30	lifespan	lifespan	NNP
cord-299731-sis9952k	344	31	Mammalian	mammalian	JJ
cord-299731-sis9952k	344	32	sirtuins	sirtuin	NNS
cord-299731-sis9952k	344	33	:	:	:
cord-299731-sis9952k	344	34	Biological	biological	JJ
cord-299731-sis9952k	344	35	insights	insight	NNS
cord-299731-sis9952k	344	36	and	and	CC
cord-299731-sis9952k	344	37	disease	disease	NN
cord-299731-sis9952k	344	38	relevance	relevance	NN
cord-299731-sis9952k	344	39	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	344	40	mononucleotide	mononucleotide	NN
cord-299731-sis9952k	344	41	activation	activation	NN
cord-299731-sis9952k	344	42	of	of	IN
cord-299731-sis9952k	344	43	new	new	JJ
cord-299731-sis9952k	344	44	DNA	dna	NN
cord-299731-sis9952k	344	45	-	-	HYPH
cord-299731-sis9952k	344	46	dependent	dependent	JJ
cord-299731-sis9952k	344	47	polyadenylic	polyadenylic	JJ
cord-299731-sis9952k	344	48	acid	acid	NN
cord-299731-sis9952k	344	49	synthesizing	synthesize	VBG
cord-299731-sis9952k	344	50	nuclear	nuclear	JJ
cord-299731-sis9952k	344	51	enzyme	enzyme	NN
cord-299731-sis9952k	344	52	Autocrine	Autocrine	NNP
cord-299731-sis9952k	344	53	and	and	CC
cord-299731-sis9952k	344	54	paracrine	paracrine	JJ
cord-299731-sis9952k	344	55	calcium	calcium	NN
cord-299731-sis9952k	344	56	signaling	signal	VBG
cord-299731-sis9952k	344	57	by	by	IN
cord-299731-sis9952k	344	58	the	the	DT
cord-299731-sis9952k	344	59	CD38	CD38	NNP
cord-299731-sis9952k	344	60	/	/	SYM
cord-299731-sis9952k	344	61	NAD+/cyclic	NAD+/cyclic	NNP
cord-299731-sis9952k	344	62	ADP	ADP	NNP
cord-299731-sis9952k	344	63	-	-	HYPH
cord-299731-sis9952k	344	64	ribose	ribose	NN
cord-299731-sis9952k	344	65	system	system	NN
cord-299731-sis9952k	345	1	Transcriptional	transcriptional	JJ
cord-299731-sis9952k	345	2	silencing	silencing	NN
cord-299731-sis9952k	345	3	and	and	CC
cord-299731-sis9952k	345	4	longevity	longevity	NN
cord-299731-sis9952k	345	5	protein	protein	NN
cord-299731-sis9952k	346	1	Sir2	Sir2	NNP
cord-299731-sis9952k	346	2	is	be	VBZ
cord-299731-sis9952k	346	3	an	an	DT
cord-299731-sis9952k	346	4	NAD+-dependent	nad+-dependent	NN
cord-299731-sis9952k	346	5	histone	histone	NN
cord-299731-sis9952k	346	6	deacetylase	deacetylase	NN
cord-299731-sis9952k	346	7	Discoveries	discovery	NNS
cord-299731-sis9952k	346	8	of	of	IN
cord-299731-sis9952k	346	9	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	346	10	riboside	riboside	JJ
cord-299731-sis9952k	346	11	as	as	IN
cord-299731-sis9952k	346	12	a	a	DT
cord-299731-sis9952k	346	13	nutrient	nutrient	NN
cord-299731-sis9952k	346	14	and	and	CC
cord-299731-sis9952k	346	15	conserved	conserve	VBN
cord-299731-sis9952k	346	16	NRKgenes	NRKgenes	NNPS
cord-299731-sis9952k	346	17	establish	establish	VBP
cord-299731-sis9952k	346	18	a	a	DT
cord-299731-sis9952k	346	19	Preiss	Preiss	NNP
cord-299731-sis9952k	346	20	-	-	HYPH
cord-299731-sis9952k	346	21	Handler	handler	NN
cord-299731-sis9952k	346	22	independent	independent	JJ
cord-299731-sis9952k	346	23	route	route	NN
cord-299731-sis9952k	346	24	to	to	IN
cord-299731-sis9952k	346	25	NAD+	NAD+	NNP
cord-299731-sis9952k	346	26	in	in	RB
cord-299731-sis9952k	347	1	fungi	fungus	NNS
cord-299731-sis9952k	347	2	and	and	CC
cord-299731-sis9952k	347	3	humans	human	NNS
cord-299731-sis9952k	347	4	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	347	5	riboside	riboside	NN
cord-299731-sis9952k	347	6	promotes	promote	VBZ
cord-299731-sis9952k	347	7	Sir2	Sir2	NNP
cord-299731-sis9952k	347	8	silencing	silencing	NN
cord-299731-sis9952k	347	9	and	and	CC
cord-299731-sis9952k	347	10	extends	extend	VBZ
cord-299731-sis9952k	347	11	lifespan	lifespan	NN
cord-299731-sis9952k	347	12	via	via	IN
cord-299731-sis9952k	347	13	Nrk	Nrk	NNP
cord-299731-sis9952k	347	14	and	and	CC
cord-299731-sis9952k	347	15	Urh1	Urh1	NNP
cord-299731-sis9952k	347	16	/	/	SYM
cord-299731-sis9952k	347	17	Pnp1	Pnp1	NNP
cord-299731-sis9952k	347	18	/	/	SYM
cord-299731-sis9952k	347	19	Meu1	meu1	JJ
cord-299731-sis9952k	347	20	pathways	pathway	NNS
cord-299731-sis9952k	347	21	to	to	IN
cord-299731-sis9952k	347	22	NAD+	NAD+	NNP
cord-299731-sis9952k	348	1	The	the	DT
cord-299731-sis9952k	348	2	NAD+	NAD+	NNP
cord-299731-sis9952k	348	3	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	348	4	pathway	pathway	NN
cord-299731-sis9952k	348	5	mediated	mediate	VBN
cord-299731-sis9952k	348	6	by	by	IN
cord-299731-sis9952k	348	7	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	348	8	phosphoribosyltransferase	phosphoribosyltransferase	NNP
cord-299731-sis9952k	348	9	regulates	regulate	VBZ
cord-299731-sis9952k	348	10	Sir2	Sir2	NNP
cord-299731-sis9952k	348	11	activity	activity	NN
cord-299731-sis9952k	348	12	in	in	IN
cord-299731-sis9952k	348	13	mammalian	mammalian	JJ
cord-299731-sis9952k	348	14	cells	cell	NNS
cord-299731-sis9952k	348	15	Structure	Structure	NNP
cord-299731-sis9952k	348	16	of	of	IN
cord-299731-sis9952k	348	17	Nampt	Nampt	NNP
cord-299731-sis9952k	348	18	/	/	SYM
cord-299731-sis9952k	348	19	PBEF	PBEF	NNP
cord-299731-sis9952k	348	20	/	/	SYM
cord-299731-sis9952k	348	21	visfatin	visfatin	NNP
cord-299731-sis9952k	348	22	,	,	,
cord-299731-sis9952k	348	23	a	a	DT
cord-299731-sis9952k	348	24	mammalian	mammalian	JJ
cord-299731-sis9952k	348	25	NAD+	NAD+	NNP
cord-299731-sis9952k	348	26	biosynthetic	biosynthetic	NN
cord-299731-sis9952k	348	27	enzyme	enzyme	NN
cord-299731-sis9952k	348	28	Nicotinic	nicotinic	JJ
cord-299731-sis9952k	348	29	acid	acid	NN
cord-299731-sis9952k	348	30	,	,	,
cord-299731-sis9952k	348	31	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	348	32	,	,	,
cord-299731-sis9952k	348	33	and	and	CC
cord-299731-sis9952k	348	34	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	348	35	riboside	riboside	NN
cord-299731-sis9952k	348	36	:	:	:
cord-299731-sis9952k	348	37	A	a	DT
cord-299731-sis9952k	348	38	molecular	molecular	JJ
cord-299731-sis9952k	348	39	evaluation	evaluation	NN
cord-299731-sis9952k	348	40	of	of	IN
cord-299731-sis9952k	348	41	NAD+	NAD+	NNP
cord-299731-sis9952k	348	42	precursor	precursor	NN
cord-299731-sis9952k	348	43	vitamins	vitamin	NNS
cord-299731-sis9952k	348	44	in	in	IN
cord-299731-sis9952k	348	45	human	human	JJ
cord-299731-sis9952k	348	46	nutrition	nutrition	NN
cord-299731-sis9952k	348	47	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	348	48	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	348	49	,	,	,
cord-299731-sis9952k	348	50	a	a	DT
cord-299731-sis9952k	348	51	key	key	JJ
cord-299731-sis9952k	348	52	NAD+	NAD+	NNP
cord-299731-sis9952k	348	53	intermediate	intermediate	JJ
cord-299731-sis9952k	348	54	,	,	,
cord-299731-sis9952k	348	55	treats	treat	VBZ
cord-299731-sis9952k	348	56	the	the	DT
cord-299731-sis9952k	348	57	pathophysiology	pathophysiology	NN
cord-299731-sis9952k	348	58	of	of	IN
cord-299731-sis9952k	348	59	diet	diet	NN
cord-299731-sis9952k	348	60	-	-	HYPH
cord-299731-sis9952k	348	61	and	and	CC
cord-299731-sis9952k	348	62	age	age	NN
cord-299731-sis9952k	348	63	-	-	HYPH
cord-299731-sis9952k	348	64	induced	induce	VBN
cord-299731-sis9952k	348	65	diabetes	diabetes	NN
cord-299731-sis9952k	348	66	in	in	IN
cord-299731-sis9952k	348	67	mice	mouse	NNS
cord-299731-sis9952k	349	1	Declining	decline	VBG
cord-299731-sis9952k	349	2	NAD+	NAD+	NNP
cord-299731-sis9952k	349	3	Induces	induce	VBZ
cord-299731-sis9952k	349	4	a	a	DT
cord-299731-sis9952k	349	5	Pseudohypoxic	Pseudohypoxic	NNP
cord-299731-sis9952k	349	6	State	State	NNP
cord-299731-sis9952k	349	7	Disrupting	Disrupting	NNP
cord-299731-sis9952k	349	8	Nuclear	Nuclear	NNP
cord-299731-sis9952k	349	9	-	-	HYPH
cord-299731-sis9952k	349	10	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	349	11	Communication	Communication	NNP
cord-299731-sis9952k	349	12	during	during	IN
cord-299731-sis9952k	349	13	Mapping	Mapping	NNP
cord-299731-sis9952k	349	14	NAD+	NAD+	NNP
cord-299731-sis9952k	349	15	metabolism	metabolism	NN
cord-299731-sis9952k	349	16	in	in	IN
cord-299731-sis9952k	349	17	the	the	DT
cord-299731-sis9952k	349	18	brain	brain	NN
cord-299731-sis9952k	349	19	of	of	IN
cord-299731-sis9952k	349	20	ageing	age	VBG
cord-299731-sis9952k	349	21	Wistar	Wistar	NNP
cord-299731-sis9952k	349	22	rats	rat	NNS
cord-299731-sis9952k	349	23	:	:	:
cord-299731-sis9952k	350	1	Potential	potential	JJ
cord-299731-sis9952k	350	2	targets	target	NNS
cord-299731-sis9952k	350	3	for	for	IN
cord-299731-sis9952k	350	4	influencing	influence	VBG
cord-299731-sis9952k	350	5	brain	brain	NN
cord-299731-sis9952k	350	6	senescence	senescence	NN
cord-299731-sis9952k	350	7	Novel	Novel	NNP
cord-299731-sis9952k	350	8	assay	assay	NN
cord-299731-sis9952k	350	9	for	for	IN
cord-299731-sis9952k	350	10	simultaneous	simultaneous	JJ
cord-299731-sis9952k	350	11	measurement	measurement	NN
cord-299731-sis9952k	350	12	of	of	IN
cord-299731-sis9952k	350	13	pyridine	pyridine	NN
cord-299731-sis9952k	350	14	mononucleotides	mononucleotide	NNS
cord-299731-sis9952k	350	15	synthesizing	synthesize	VBG
cord-299731-sis9952k	350	16	activities	activity	NNS
cord-299731-sis9952k	350	17	allows	allow	VBZ
cord-299731-sis9952k	350	18	dissection	dissection	NN
cord-299731-sis9952k	350	19	of	of	IN
cord-299731-sis9952k	350	20	the	the	DT
cord-299731-sis9952k	350	21	NAD+biosynthetic	nad+biosynthetic	JJ
cord-299731-sis9952k	350	22	machinery	machinery	NN
cord-299731-sis9952k	350	23	in	in	IN
cord-299731-sis9952k	350	24	mammalian	mammalian	JJ
cord-299731-sis9952k	350	25	cells	cell	NNS
cord-299731-sis9952k	350	26	Metabolic	metabolic	JJ
cord-299731-sis9952k	350	27	Profiling	profiling	NN
cord-299731-sis9952k	350	28	of	of	IN
cord-299731-sis9952k	350	29	Alternative	Alternative	NNP
cord-299731-sis9952k	350	30	NAD	NAD	NNP
cord-299731-sis9952k	350	31	Biosynthetic	Biosynthetic	NNP
cord-299731-sis9952k	350	32	Routes	Routes	NNPS
cord-299731-sis9952k	350	33	in	in	IN
cord-299731-sis9952k	350	34	Mouse	Mouse	NNP
cord-299731-sis9952k	350	35	Tissues	Tissues	NNP
cord-299731-sis9952k	350	36	Specific	specific	JJ
cord-299731-sis9952k	350	37	ablation	ablation	NN
cord-299731-sis9952k	350	38	of	of	IN
cord-299731-sis9952k	350	39	Nampt	Nampt	NNP
cord-299731-sis9952k	350	40	in	in	IN
cord-299731-sis9952k	350	41	adult	adult	JJ
cord-299731-sis9952k	350	42	neural	neural	JJ
cord-299731-sis9952k	350	43	stem	stem	NN
cord-299731-sis9952k	350	44	cells	cell	NNS
cord-299731-sis9952k	350	45	recapitulates	recapitulate	VBZ
cord-299731-sis9952k	350	46	their	-PRON-	PRP$
cord-299731-sis9952k	350	47	functional	functional	JJ
cord-299731-sis9952k	350	48	defects	defect	NNS
cord-299731-sis9952k	350	49	during	during	IN
cord-299731-sis9952k	350	50	aging	age	VBG
cord-299731-sis9952k	350	51	NAD	NAD	NNP
cord-299731-sis9952k	350	52	synthesis	synthesis	NN
cord-299731-sis9952k	350	53	in	in	IN
cord-299731-sis9952k	350	54	animal	animal	NN
cord-299731-sis9952k	350	55	tissues	tissue	NNS
cord-299731-sis9952k	351	1	Sirtuins	Sirtuins	NNP
cord-299731-sis9952k	351	2	:	:	:
cord-299731-sis9952k	351	3	The	the	DT
cord-299731-sis9952k	351	4	"	"	``
cord-299731-sis9952k	351	5	magnificent	magnificent	JJ
cord-299731-sis9952k	351	6	seven	seven	CD
cord-299731-sis9952k	351	7	,	,	,
cord-299731-sis9952k	351	8	"	"	''
cord-299731-sis9952k	351	9	function	function	NN
cord-299731-sis9952k	351	10	,	,	,
cord-299731-sis9952k	351	11	metabolism	metabolism	NN
cord-299731-sis9952k	351	12	and	and	CC
cord-299731-sis9952k	351	13	longevity	longevity	NN
cord-299731-sis9952k	352	1	It	-PRON-	PRP
cord-299731-sis9952k	352	2	takes	take	VBZ
cord-299731-sis9952k	352	3	two	two	CD
cord-299731-sis9952k	352	4	to	to	IN
cord-299731-sis9952k	352	5	tango	tango	NN
cord-299731-sis9952k	352	6	:	:	:
cord-299731-sis9952k	353	1	NAD+	NAD+	NNP
cord-299731-sis9952k	353	2	and	and	CC
cord-299731-sis9952k	353	3	sirtuins	sirtuin	NNS
cord-299731-sis9952k	353	4	in	in	IN
cord-299731-sis9952k	353	5	aging	age	VBG
cord-299731-sis9952k	353	6	/	/	SYM
cord-299731-sis9952k	353	7	longevity	longevity	NN
cord-299731-sis9952k	353	8	control	control	NN
cord-299731-sis9952k	353	9	PARP-1	parp-1	JJ
cord-299731-sis9952k	353	10	inhibition	inhibition	NN
cord-299731-sis9952k	353	11	increases	increase	NNS
cord-299731-sis9952k	353	12	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	353	13	metabolism	metabolism	NN
cord-299731-sis9952k	353	14	through	through	IN
cord-299731-sis9952k	353	15	SIRT1	sirt1	NN
cord-299731-sis9952k	353	16	activation	activation	NN
cord-299731-sis9952k	353	17	ADP	ADP	NNP
cord-299731-sis9952k	353	18	ribosyl	ribosyl	NN
cord-299731-sis9952k	353	19	cyclase	cyclase	NN
cord-299731-sis9952k	353	20	activity	activity	NN
cord-299731-sis9952k	353	21	of	of	IN
cord-299731-sis9952k	353	22	a	a	DT
cord-299731-sis9952k	353	23	novel	novel	JJ
cord-299731-sis9952k	353	24	bone	bone	NN
cord-299731-sis9952k	353	25	marrow	marrow	NN
cord-299731-sis9952k	353	26	stromal	stromal	NN
cord-299731-sis9952k	353	27	cell	cell	NN
cord-299731-sis9952k	353	28	surface	surface	NN
cord-299731-sis9952k	353	29	molecule	molecule	NN
cord-299731-sis9952k	353	30	,	,	,
cord-299731-sis9952k	354	1	BST-1	BST-1	NNP
cord-299731-sis9952k	354	2	Formation	formation	NN
cord-299731-sis9952k	354	3	and	and	CC
cord-299731-sis9952k	354	4	hydrolysis	hydrolysis	NN
cord-299731-sis9952k	354	5	of	of	IN
cord-299731-sis9952k	354	6	cyclic	cyclic	JJ
cord-299731-sis9952k	354	7	ADP	adp	NN
cord-299731-sis9952k	354	8	-	-	HYPH
cord-299731-sis9952k	354	9	ribose	ribose	NN
cord-299731-sis9952k	354	10	catalyzed	catalyze	VBN
cord-299731-sis9952k	354	11	by	by	IN
cord-299731-sis9952k	354	12	lymphocyte	lymphocyte	NN
cord-299731-sis9952k	354	13	antigen	antigen	NN
cord-299731-sis9952k	354	14	CD38	CD38	NNP
cord-299731-sis9952k	354	15	Synthesis	Synthesis	NNP
cord-299731-sis9952k	354	16	and	and	CC
cord-299731-sis9952k	354	17	degradation	degradation	NN
cord-299731-sis9952k	354	18	of	of	IN
cord-299731-sis9952k	354	19	cyclic	cyclic	JJ
cord-299731-sis9952k	354	20	ADP	adp	NN
cord-299731-sis9952k	354	21	-	-	HYPH
cord-299731-sis9952k	354	22	ribose	ribose	NN
cord-299731-sis9952k	354	23	by	by	IN
cord-299731-sis9952k	354	24	NAD	NAD	NNP
cord-299731-sis9952k	354	25	glycohydrolases	glycohydrolase	NNS
cord-299731-sis9952k	354	26	CD73	CD73	NNP
cord-299731-sis9952k	354	27	protein	protein	NN
cord-299731-sis9952k	354	28	as	as	IN
cord-299731-sis9952k	354	29	a	a	DT
cord-299731-sis9952k	354	30	source	source	NN
cord-299731-sis9952k	354	31	of	of	IN
cord-299731-sis9952k	354	32	extracellular	extracellular	JJ
cord-299731-sis9952k	354	33	precursors	precursor	NNS
cord-299731-sis9952k	354	34	for	for	IN
cord-299731-sis9952k	354	35	sustained	sustained	JJ
cord-299731-sis9952k	354	36	NAD+	NAD+	NNP
cord-299731-sis9952k	354	37	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	354	38	in	in	IN
cord-299731-sis9952k	354	39	FK866-treated	FK866-treated	NNP
cord-299731-sis9952k	354	40	tumor	tumor	NN
cord-299731-sis9952k	354	41	cells	cell	NNS
cord-299731-sis9952k	355	1	A	a	DT
cord-299731-sis9952k	355	2	pre	pre	JJ
cord-299731-sis9952k	355	3	-	-	JJ
cord-299731-sis9952k	355	4	steady	steady	JJ
cord-299731-sis9952k	355	5	state	state	NN
cord-299731-sis9952k	355	6	and	and	CC
cord-299731-sis9952k	355	7	steady	steady	JJ
cord-299731-sis9952k	355	8	state	state	NN
cord-299731-sis9952k	355	9	kinetic	kinetic	JJ
cord-299731-sis9952k	355	10	analysis	analysis	NN
cord-299731-sis9952k	355	11	of	of	IN
cord-299731-sis9952k	355	12	the	the	DT
cord-299731-sis9952k	355	13	N	n	CD
cord-299731-sis9952k	355	14	-	-	HYPH
cord-299731-sis9952k	355	15	ribosyl	ribosyl	NNP
cord-299731-sis9952k	355	16	hydrolase	hydrolase	NN
cord-299731-sis9952k	355	17	activity	activity	NN
cord-299731-sis9952k	355	18	of	of	IN
cord-299731-sis9952k	355	19	hCD157	hcd157	DT
cord-299731-sis9952k	355	20	CD38	CD38	NNP
cord-299731-sis9952k	355	21	Dictates	dictate	VBZ
cord-299731-sis9952k	355	22	Age	Age	NNP
cord-299731-sis9952k	355	23	-	-	HYPH
cord-299731-sis9952k	355	24	Related	relate	VBN
cord-299731-sis9952k	355	25	NAD	NAD	NNP
cord-299731-sis9952k	355	26	Decline	Decline	NNP
cord-299731-sis9952k	355	27	and	and	CC
cord-299731-sis9952k	355	28	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	355	29	Dysfunction	Dysfunction	NNP
cord-299731-sis9952k	355	30	through	through	IN
cord-299731-sis9952k	355	31	an	an	DT
cord-299731-sis9952k	355	32	SIRT3-Dependent	SIRT3-Dependent	NNP
cord-299731-sis9952k	355	33	Mechanism	Mechanism	NNP
cord-299731-sis9952k	355	34	Regulation	regulation	NN
cord-299731-sis9952k	355	35	of	of	IN
cord-299731-sis9952k	355	36	intracellular	intracellular	JJ
cord-299731-sis9952k	355	37	levels	level	NNS
cord-299731-sis9952k	355	38	of	of	IN
cord-299731-sis9952k	355	39	NAD	NAD	NNP
cord-299731-sis9952k	355	40	:	:	:
cord-299731-sis9952k	355	41	A	a	DT
cord-299731-sis9952k	355	42	novel	novel	JJ
cord-299731-sis9952k	355	43	role	role	NN
cord-299731-sis9952k	355	44	for	for	IN
cord-299731-sis9952k	355	45	CD38	CD38	NNP
cord-299731-sis9952k	355	46	Flavonoid	flavonoid	JJ
cord-299731-sis9952k	355	47	apigenin	apigenin	NN
cord-299731-sis9952k	355	48	is	be	VBZ
cord-299731-sis9952k	355	49	an	an	DT
cord-299731-sis9952k	355	50	inhibitor	inhibitor	NN
cord-299731-sis9952k	355	51	of	of	IN
cord-299731-sis9952k	355	52	the	the	DT
cord-299731-sis9952k	355	53	NAD+	NAD+	NNP
cord-299731-sis9952k	355	54	ase	ase	NNP
cord-299731-sis9952k	355	55	CD38	CD38	NNP
cord-299731-sis9952k	355	56	:	:	:
cord-299731-sis9952k	355	57	Implications	implication	NNS
cord-299731-sis9952k	355	58	for	for	IN
cord-299731-sis9952k	355	59	cellular	cellular	JJ
cord-299731-sis9952k	355	60	NAD+	NAD+	NNP
cord-299731-sis9952k	355	61	metabolism	metabolism	NN
cord-299731-sis9952k	355	62	,	,	,
cord-299731-sis9952k	355	63	protein	protein	NN
cord-299731-sis9952k	355	64	acetylation	acetylation	NN
cord-299731-sis9952k	355	65	,	,	,
cord-299731-sis9952k	355	66	and	and	CC
cord-299731-sis9952k	355	67	treatment	treatment	NN
cord-299731-sis9952k	355	68	of	of	IN
cord-299731-sis9952k	355	69	metabolic	metabolic	JJ
cord-299731-sis9952k	355	70	syndrome	syndrome	NN
cord-299731-sis9952k	356	1	The	the	DT
cord-299731-sis9952k	356	2	SARM1	sarm1	XX
cord-299731-sis9952k	356	3	Toll	Toll	NNP
cord-299731-sis9952k	356	4	/	/	SYM
cord-299731-sis9952k	356	5	Interleukin-1	Interleukin-1	NNP
cord-299731-sis9952k	356	6	Receptor	Receptor	NNP
cord-299731-sis9952k	356	7	Domain	Domain	NNP
cord-299731-sis9952k	356	8	Possesses	possess	VBZ
cord-299731-sis9952k	357	1	Intrinsic	intrinsic	JJ
cord-299731-sis9952k	357	2	NAD+	NAD+	NNP
cord-299731-sis9952k	357	3	Cleavage	Cleavage	NNP
cord-299731-sis9952k	357	4	Activity	Activity	NNP
cord-299731-sis9952k	357	5	that	that	WDT
cord-299731-sis9952k	357	6	Promotes	promote	VBZ
cord-299731-sis9952k	357	7	Pathological	Pathological	NNP
cord-299731-sis9952k	357	8	Axonal	Axonal	NNP
cord-299731-sis9952k	357	9	Degeneration	Degeneration	NNP
cord-299731-sis9952k	357	10	SIRT3	sirt3	NN
cord-299731-sis9952k	357	11	Regulation	regulation	NN
cord-299731-sis9952k	357	12	of	of	IN
cord-299731-sis9952k	357	13	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	357	14	Quality	Quality	NNP
cord-299731-sis9952k	357	15	Control	Control	NNP
cord-299731-sis9952k	357	16	in	in	IN
cord-299731-sis9952k	357	17	Neurodegenerative	Neurodegenerative	NNP
cord-299731-sis9952k	357	18	Diseases	Diseases	NNPS
cord-299731-sis9952k	357	19	Long	Long	NNP
cord-299731-sis9952k	357	20	-	-	HYPH
cord-299731-sis9952k	357	21	Term	Term	NNP
cord-299731-sis9952k	357	22	Administration	Administration	NNP
cord-299731-sis9952k	357	23	of	of	IN
cord-299731-sis9952k	357	24	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	357	25	Mononucleotide	Mononucleotide	NNP
cord-299731-sis9952k	357	26	Mitigates	mitigate	VBZ
cord-299731-sis9952k	357	27	Age	Age	NNP
cord-299731-sis9952k	357	28	-	-	HYPH
cord-299731-sis9952k	357	29	Associated	Associated	NNP
cord-299731-sis9952k	357	30	Physiological	physiological	JJ
cord-299731-sis9952k	357	31	Decline	decline	NN
cord-299731-sis9952k	357	32	in	in	IN
cord-299731-sis9952k	357	33	Mice	mice	NN
cord-299731-sis9952k	358	1	The	the	DT
cord-299731-sis9952k	358	2	Biology	Biology	NNP
cord-299731-sis9952k	358	3	and	and	CC
cord-299731-sis9952k	358	4	Therapeutic	therapeutic	JJ
cord-299731-sis9952k	358	5	Potential	potential	NN
cord-299731-sis9952k	358	6	of	of	IN
cord-299731-sis9952k	358	7	NMN	NMN	NNP
cord-299731-sis9952k	358	8	and	and	CC
cord-299731-sis9952k	359	1	NR	NR	NNP
cord-299731-sis9952k	359	2	The	the	DT
cord-299731-sis9952k	359	3	NAD(+	nad(+	CD
cord-299731-sis9952k	359	4	)	)	-RRB-
cord-299731-sis9952k	359	5	precursor	precursor	NN
cord-299731-sis9952k	359	6	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	359	7	riboside	riboside	NN
cord-299731-sis9952k	359	8	enhances	enhance	VBZ
cord-299731-sis9952k	359	9	oxidative	oxidative	JJ
cord-299731-sis9952k	359	10	metabolism	metabolism	NN
cord-299731-sis9952k	359	11	and	and	CC
cord-299731-sis9952k	359	12	protects	protect	VBZ
cord-299731-sis9952k	359	13	against	against	IN
cord-299731-sis9952k	359	14	high	high	JJ
cord-299731-sis9952k	359	15	-	-	HYPH
cord-299731-sis9952k	359	16	fat	fat	NN
cord-299731-sis9952k	359	17	diet	diet	NN
cord-299731-sis9952k	359	18	-	-	HYPH
cord-299731-sis9952k	359	19	induced	induce	VBN
cord-299731-sis9952k	359	20	obesity	obesity	NN
cord-299731-sis9952k	359	21	NAD	NAD	NNP
cord-299731-sis9952k	360	1	+	+	CC
cord-299731-sis9952k	360	2	repletion	repletion	NN
cord-299731-sis9952k	360	3	improves	improve	VBZ
cord-299731-sis9952k	360	4	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	360	5	and	and	CC
cord-299731-sis9952k	360	6	stem	stem	NN
cord-299731-sis9952k	360	7	cell	cell	NN
cord-299731-sis9952k	360	8	function	function	NN
cord-299731-sis9952k	360	9	and	and	CC
cord-299731-sis9952k	360	10	enhances	enhance	VBZ
cord-299731-sis9952k	360	11	life	life	NN
cord-299731-sis9952k	360	12	span	span	NN
cord-299731-sis9952k	360	13	in	in	IN
cord-299731-sis9952k	360	14	mice	mouse	NNS
cord-299731-sis9952k	361	1	Chronic	chronic	JJ
cord-299731-sis9952k	361	2	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	361	3	riboside	riboside	NN
cord-299731-sis9952k	361	4	supplementation	supplementation	NN
cord-299731-sis9952k	361	5	is	be	VBZ
cord-299731-sis9952k	361	6	well	well	RB
cord-299731-sis9952k	361	7	-	-	HYPH
cord-299731-sis9952k	361	8	tolerated	tolerate	VBN
cord-299731-sis9952k	361	9	and	and	CC
cord-299731-sis9952k	361	10	elevates	elevate	VBZ
cord-299731-sis9952k	361	11	NAD+	NAD+	NNP
cord-299731-sis9952k	361	12	in	in	IN
cord-299731-sis9952k	361	13	healthy	healthy	JJ
cord-299731-sis9952k	361	14	middle	middle	NN
cord-299731-sis9952k	361	15	-	-	HYPH
cord-299731-sis9952k	361	16	aged	aged	JJ
cord-299731-sis9952k	361	17	and	and	CC
cord-299731-sis9952k	361	18	older	old	JJR
cord-299731-sis9952k	361	19	adults	adult	NNS
cord-299731-sis9952k	362	1	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	362	2	Riboside	Riboside	NNP
cord-299731-sis9952k	362	3	Opposes	oppose	VBZ
cord-299731-sis9952k	362	4	Type	type	NN
cord-299731-sis9952k	362	5	2	2	CD
cord-299731-sis9952k	362	6	Diabetes	diabetes	NN
cord-299731-sis9952k	362	7	and	and	CC
cord-299731-sis9952k	362	8	Neuropathy	neuropathy	NN
cord-299731-sis9952k	362	9	in	in	IN
cord-299731-sis9952k	362	10	Mice	Mice	NNP
cord-299731-sis9952k	362	11	Reactive	reactive	JJ
cord-299731-sis9952k	362	12	oxygen	oxygen	NN
cord-299731-sis9952k	362	13	species	specie	NNS
cord-299731-sis9952k	362	14	have	have	VBP
cord-299731-sis9952k	362	15	a	a	DT
cord-299731-sis9952k	362	16	causal	causal	JJ
cord-299731-sis9952k	362	17	role	role	NN
cord-299731-sis9952k	362	18	in	in	IN
cord-299731-sis9952k	362	19	multiple	multiple	JJ
cord-299731-sis9952k	362	20	forms	form	NNS
cord-299731-sis9952k	362	21	of	of	IN
cord-299731-sis9952k	362	22	insulin	insulin	NN
cord-299731-sis9952k	362	23	resistance	resistance	NN
cord-299731-sis9952k	363	1	A	a	DT
cord-299731-sis9952k	363	2	randomized	randomized	JJ
cord-299731-sis9952k	363	3	placebo	placebo	NN
cord-299731-sis9952k	363	4	-	-	HYPH
cord-299731-sis9952k	363	5	controlled	control	VBN
cord-299731-sis9952k	363	6	clinical	clinical	JJ
cord-299731-sis9952k	363	7	trial	trial	NN
cord-299731-sis9952k	363	8	of	of	IN
cord-299731-sis9952k	363	9	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	363	10	riboside	riboside	NN
cord-299731-sis9952k	363	11	in	in	IN
cord-299731-sis9952k	363	12	obese	obese	JJ
cord-299731-sis9952k	363	13	men	man	NNS
cord-299731-sis9952k	363	14	:	:	:
cord-299731-sis9952k	363	15	Safety	safety	NN
cord-299731-sis9952k	363	16	,	,	,
cord-299731-sis9952k	363	17	insulin	insulin	NN
cord-299731-sis9952k	363	18	-	-	HYPH
cord-299731-sis9952k	363	19	sensitivity	sensitivity	NN
cord-299731-sis9952k	363	20	,	,	,
cord-299731-sis9952k	363	21	and	and	CC
cord-299731-sis9952k	363	22	lipid	lipid	NN
cord-299731-sis9952k	363	23	-	-	HYPH
cord-299731-sis9952k	363	24	mobilizing	mobilize	VBG
cord-299731-sis9952k	363	25	effects	effect	NNS
cord-299731-sis9952k	363	26	Eliciting	elicit	VBG
cord-299731-sis9952k	363	27	the	the	DT
cord-299731-sis9952k	363	28	mitochondrial	mitochondrial	NN
cord-299731-sis9952k	363	29	unfolded	unfold	VBD
cord-299731-sis9952k	363	30	protein	protein	NN
cord-299731-sis9952k	363	31	response	response	NN
cord-299731-sis9952k	363	32	by	by	IN
cord-299731-sis9952k	364	1	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	364	2	adenine	adenine	NN
cord-299731-sis9952k	364	3	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	364	4	repletion	repletion	NN
cord-299731-sis9952k	364	5	reverses	reverse	VBZ
cord-299731-sis9952k	364	6	fatty	fatty	JJ
cord-299731-sis9952k	364	7	liver	liver	NN
cord-299731-sis9952k	364	8	disease	disease	NN
cord-299731-sis9952k	364	9	in	in	IN
cord-299731-sis9952k	364	10	mice	mouse	NNS
cord-299731-sis9952k	365	1	Sirt1	Sirt1	NNP
cord-299731-sis9952k	365	2	activation	activation	NN
cord-299731-sis9952k	365	3	protects	protect	VBZ
cord-299731-sis9952k	365	4	the	the	DT
cord-299731-sis9952k	365	5	mouse	mouse	NN
cord-299731-sis9952k	365	6	renal	renal	JJ
cord-299731-sis9952k	365	7	medulla	medulla	NN
cord-299731-sis9952k	365	8	from	from	IN
cord-299731-sis9952k	365	9	oxidative	oxidative	JJ
cord-299731-sis9952k	365	10	injury	injury	NN
cord-299731-sis9952k	366	1	Sirt1	Sirt1	NNP
cord-299731-sis9952k	366	2	regulates	regulate	VBZ
cord-299731-sis9952k	366	3	insulin	insulin	NN
cord-299731-sis9952k	366	4	secretion	secretion	NN
cord-299731-sis9952k	366	5	by	by	IN
cord-299731-sis9952k	366	6	repressing	repress	VBG
cord-299731-sis9952k	366	7	UCP2	UCP2	NNP
cord-299731-sis9952k	366	8	in	in	IN
cord-299731-sis9952k	366	9	pancreatic	pancreatic	JJ
cord-299731-sis9952k	366	10	beta	beta	NN
cord-299731-sis9952k	366	11	cells	cell	NNS
cord-299731-sis9952k	367	1	Increased	increase	VBN
cord-299731-sis9952k	367	2	dosage	dosage	NN
cord-299731-sis9952k	367	3	of	of	IN
cord-299731-sis9952k	367	4	mammalian	mammalian	JJ
cord-299731-sis9952k	367	5	Sir2	Sir2	NNP
cord-299731-sis9952k	367	6	in	in	IN
cord-299731-sis9952k	367	7	pancreatic	pancreatic	JJ
cord-299731-sis9952k	367	8	beta	beta	NN
cord-299731-sis9952k	367	9	cells	cell	NNS
cord-299731-sis9952k	367	10	enhances	enhance	VBZ
cord-299731-sis9952k	367	11	glucose	glucose	NN
cord-299731-sis9952k	367	12	-	-	HYPH
cord-299731-sis9952k	367	13	stimulated	stimulate	VBN
cord-299731-sis9952k	367	14	insulin	insulin	NN
cord-299731-sis9952k	367	15	secretion	secretion	NN
cord-299731-sis9952k	367	16	in	in	IN
cord-299731-sis9952k	367	17	mice	mouse	NNS
cord-299731-sis9952k	368	1	Sirt1	Sirt1	NNP
cord-299731-sis9952k	368	2	protects	protect	VBZ
cord-299731-sis9952k	368	3	against	against	IN
cord-299731-sis9952k	368	4	high	high	JJ
cord-299731-sis9952k	368	5	-	-	HYPH
cord-299731-sis9952k	368	6	fat	fat	NN
cord-299731-sis9952k	368	7	diet	diet	NN
cord-299731-sis9952k	368	8	-	-	HYPH
cord-299731-sis9952k	368	9	induced	induce	VBN
cord-299731-sis9952k	368	10	metabolic	metabolic	JJ
cord-299731-sis9952k	368	11	damage	damage	NN
cord-299731-sis9952k	368	12	Direct	direct	JJ
cord-299731-sis9952k	368	13	evidence	evidence	NN
cord-299731-sis9952k	368	14	of	of	IN
cord-299731-sis9952k	368	15	sirtuin	sirtuin	NNP
cord-299731-sis9952k	368	16	downregulation	downregulation	NN
cord-299731-sis9952k	368	17	in	in	IN
cord-299731-sis9952k	368	18	the	the	DT
cord-299731-sis9952k	368	19	liver	liver	NN
cord-299731-sis9952k	368	20	of	of	IN
cord-299731-sis9952k	368	21	non	non	JJ
cord-299731-sis9952k	368	22	-	-	JJ
cord-299731-sis9952k	368	23	alcoholic	alcoholic	JJ
cord-299731-sis9952k	368	24	fatty	fatty	JJ
cord-299731-sis9952k	368	25	liver	liver	NN
cord-299731-sis9952k	368	26	disease	disease	NN
cord-299731-sis9952k	368	27	patients	patient	NNS
cord-299731-sis9952k	369	1	Uric	uric	JJ
cord-299731-sis9952k	369	2	acid	acid	NN
cord-299731-sis9952k	369	3	regulates	regulate	VBZ
cord-299731-sis9952k	369	4	hepatic	hepatic	JJ
cord-299731-sis9952k	369	5	steatosis	steatosis	NN
cord-299731-sis9952k	369	6	and	and	CC
cord-299731-sis9952k	369	7	insulin	insulin	NN
cord-299731-sis9952k	369	8	resistance	resistance	NN
cord-299731-sis9952k	369	9	through	through	IN
cord-299731-sis9952k	369	10	the	the	DT
cord-299731-sis9952k	369	11	NLRP3	NLRP3	NNP
cord-299731-sis9952k	369	12	inflammasome	inflammasome	NN
cord-299731-sis9952k	369	13	-	-	HYPH
cord-299731-sis9952k	369	14	dependent	dependent	JJ
cord-299731-sis9952k	369	15	mechanism	mechanism	NN
cord-299731-sis9952k	369	16	FXR	FXR	NNP
cord-299731-sis9952k	369	17	acetylation	acetylation	NN
cord-299731-sis9952k	369	18	is	be	VBZ
cord-299731-sis9952k	369	19	normally	normally	RB
cord-299731-sis9952k	369	20	dynamically	dynamically	RB
cord-299731-sis9952k	369	21	regulated	regulate	VBN
cord-299731-sis9952k	369	22	by	by	IN
cord-299731-sis9952k	369	23	p300	p300	NNP
cord-299731-sis9952k	369	24	and	and	CC
cord-299731-sis9952k	369	25	SIRT1	SIRT1	NNS
cord-299731-sis9952k	369	26	but	but	CC
cord-299731-sis9952k	369	27	constitutively	constitutively	RB
cord-299731-sis9952k	369	28	elevated	elevate	VBN
cord-299731-sis9952k	369	29	in	in	IN
cord-299731-sis9952k	369	30	metabolic	metabolic	JJ
cord-299731-sis9952k	369	31	disease	disease	NN
cord-299731-sis9952k	370	1	states	states	NNP
cord-299731-sis9952k	370	2	SIRT1	SIRT1	NNP
cord-299731-sis9952k	370	3	deacetylates	deacetylate	NNS
cord-299731-sis9952k	370	4	and	and	CC
cord-299731-sis9952k	370	5	positively	positively	RB
cord-299731-sis9952k	370	6	regulates	regulate	VBZ
cord-299731-sis9952k	370	7	the	the	DT
cord-299731-sis9952k	370	8	nuclear	nuclear	JJ
cord-299731-sis9952k	370	9	receptor	receptor	NN
cord-299731-sis9952k	371	1	LXR	LXR	NNP
cord-299731-sis9952k	371	2	PGC-1alpha	pgc-1alpha	NN
cord-299731-sis9952k	371	3	activates	activate	VBZ
cord-299731-sis9952k	371	4	CYP7A1	CYP7A1	NNP
cord-299731-sis9952k	371	5	and	and	CC
cord-299731-sis9952k	371	6	bile	bile	NN
cord-299731-sis9952k	371	7	acid	acid	NN
cord-299731-sis9952k	372	1	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	372	2	Conserved	conserved	JJ
cord-299731-sis9952k	372	3	role	role	NN
cord-299731-sis9952k	372	4	of	of	IN
cord-299731-sis9952k	372	5	SIRT1	sirt1	NN
cord-299731-sis9952k	372	6	orthologs	ortholog	NNS
cord-299731-sis9952k	372	7	in	in	IN
cord-299731-sis9952k	372	8	fasting	fast	VBG
cord-299731-sis9952k	372	9	-	-	HYPH
cord-299731-sis9952k	372	10	dependent	dependent	JJ
cord-299731-sis9952k	372	11	inhibition	inhibition	NN
cord-299731-sis9952k	372	12	of	of	IN
cord-299731-sis9952k	372	13	the	the	DT
cord-299731-sis9952k	372	14	lipid	lipid	NN
cord-299731-sis9952k	372	15	/	/	SYM
cord-299731-sis9952k	372	16	cholesterol	cholesterol	NN
cord-299731-sis9952k	372	17	regulator	regulator	NN
cord-299731-sis9952k	372	18	SREBP	SREBP	NNP
cord-299731-sis9952k	372	19	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	372	20	adenine	adenine	NN
cord-299731-sis9952k	372	21	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	372	22	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	372	23	promotes	promote	VBZ
cord-299731-sis9952k	372	24	liver	liver	NN
cord-299731-sis9952k	372	25	regeneration	regeneration	NN
cord-299731-sis9952k	372	26	Inhibition	inhibition	NN
cord-299731-sis9952k	372	27	of	of	IN
cord-299731-sis9952k	372	28	De	De	NNP
cord-299731-sis9952k	372	29	Novo	Novo	NNP
cord-299731-sis9952k	372	30	NAD(+	nad(+	CD
cord-299731-sis9952k	372	31	)	)	-RRB-
cord-299731-sis9952k	373	1	Synthesis	synthesis	NN
cord-299731-sis9952k	373	2	by	by	IN
cord-299731-sis9952k	373	3	Oncogenic	oncogenic	JJ
cord-299731-sis9952k	373	4	URI	URI	NNP
cord-299731-sis9952k	373	5	Causes	cause	VBZ
cord-299731-sis9952k	373	6	Liver	Liver	NNP
cord-299731-sis9952k	373	7	Tumorigenesis	Tumorigenesis	NNP
cord-299731-sis9952k	373	8	through	through	IN
cord-299731-sis9952k	373	9	DNA	DNA	NNP
cord-299731-sis9952k	373	10	Damage	Damage	NNP
cord-299731-sis9952k	373	11	Cardiac	Cardiac	NNP
cord-299731-sis9952k	373	12	metabolism	metabolism	NN
cord-299731-sis9952k	373	13	and	and	CC
cord-299731-sis9952k	373	14	its	-PRON-	PRP$
cord-299731-sis9952k	373	15	interactions	interaction	NNS
cord-299731-sis9952k	373	16	with	with	IN
cord-299731-sis9952k	373	17	contraction	contraction	NN
cord-299731-sis9952k	373	18	,	,	,
cord-299731-sis9952k	373	19	growth	growth	NN
cord-299731-sis9952k	373	20	,	,	,
cord-299731-sis9952k	373	21	and	and	CC
cord-299731-sis9952k	373	22	survival	survival	NN
cord-299731-sis9952k	373	23	of	of	IN
cord-299731-sis9952k	373	24	cardiomyocytes	cardiomyocyte	NNS
cord-299731-sis9952k	373	25	Mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	373	26	centrality	centrality	NN
cord-299731-sis9952k	373	27	in	in	IN
cord-299731-sis9952k	373	28	heart	heart	NN
cord-299731-sis9952k	373	29	failure	failure	NN
cord-299731-sis9952k	374	1	The	the	DT
cord-299731-sis9952k	374	2	failing	fail	VBG
cord-299731-sis9952k	374	3	heart	heart	NN
cord-299731-sis9952k	374	4	-	-	:
cord-299731-sis9952k	374	5	An	an	DT
cord-299731-sis9952k	374	6	engine	engine	NN
cord-299731-sis9952k	374	7	out	out	IN
cord-299731-sis9952k	374	8	of	of	IN
cord-299731-sis9952k	374	9	fuel	fuel	NN
cord-299731-sis9952k	374	10	Nicotinamide	nicotinamide	NN
cord-299731-sis9952k	374	11	adenine	adenine	NN
cord-299731-sis9952k	374	12	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	374	13	homeostasis	homeostasis	NN
cord-299731-sis9952k	374	14	and	and	CC
cord-299731-sis9952k	374	15	signalling	signal	VBG
cord-299731-sis9952k	374	16	in	in	IN
cord-299731-sis9952k	374	17	heart	heart	NN
cord-299731-sis9952k	374	18	disease	disease	NN
cord-299731-sis9952k	374	19	:	:	:
cord-299731-sis9952k	375	1	Pathophysiological	pathophysiological	JJ
cord-299731-sis9952k	375	2	implications	implication	NNS
cord-299731-sis9952k	375	3	and	and	CC
cord-299731-sis9952k	375	4	therapeutic	therapeutic	JJ
cord-299731-sis9952k	375	5	potential	potential	NN
cord-299731-sis9952k	376	1	Exogenous	exogenous	JJ
cord-299731-sis9952k	376	2	NAD	NAD	NNP
cord-299731-sis9952k	376	3	blocks	block	VBZ
cord-299731-sis9952k	376	4	cardiac	cardiac	JJ
cord-299731-sis9952k	376	5	hypertrophic	hypertrophic	JJ
cord-299731-sis9952k	376	6	response	response	NN
cord-299731-sis9952k	376	7	via	via	IN
cord-299731-sis9952k	376	8	activation	activation	NN
cord-299731-sis9952k	376	9	of	of	IN
cord-299731-sis9952k	376	10	the	the	DT
cord-299731-sis9952k	376	11	SIRT3-LKB1-AMP	SIRT3-LKB1-AMP	NNP
cord-299731-sis9952k	376	12	-	-	HYPH
cord-299731-sis9952k	376	13	activated	activate	VBN
cord-299731-sis9952k	376	14	kinase	kinase	NN
cord-299731-sis9952k	376	15	pathway	pathway	NN
cord-299731-sis9952k	377	1	The	the	DT
cord-299731-sis9952k	377	2	function	function	NN
cord-299731-sis9952k	377	3	of	of	IN
cord-299731-sis9952k	377	4	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	377	5	phosphoribosyltransferase	phosphoribosyltransferase	NN
cord-299731-sis9952k	377	6	in	in	IN
cord-299731-sis9952k	377	7	the	the	DT
cord-299731-sis9952k	377	8	heart	heart	NN
cord-299731-sis9952k	378	1	The	the	DT
cord-299731-sis9952k	378	2	Failing	Failing	NNP
cord-299731-sis9952k	378	3	Heart	heart	NN
cord-299731-sis9952k	378	4	Relies	rely	VBZ
cord-299731-sis9952k	378	5	on	on	IN
cord-299731-sis9952k	378	6	Ketone	Ketone	NNP
cord-299731-sis9952k	378	7	Bodies	body	NNS
cord-299731-sis9952k	378	8	as	as	IN
cord-299731-sis9952k	378	9	a	a	DT
cord-299731-sis9952k	378	10	Fuel	fuel	NN
cord-299731-sis9952k	378	11	Mitochondrion	mitochondrion	NN
cord-299731-sis9952k	378	12	as	as	IN
cord-299731-sis9952k	378	13	a	a	DT
cord-299731-sis9952k	378	14	target	target	NN
cord-299731-sis9952k	378	15	for	for	IN
cord-299731-sis9952k	378	16	heart	heart	NN
cord-299731-sis9952k	378	17	failure	failure	NN
cord-299731-sis9952k	378	18	therapy	therapy	NN
cord-299731-sis9952k	378	19	-	-	HYPH
cord-299731-sis9952k	378	20	role	role	NN
cord-299731-sis9952k	378	21	of	of	IN
cord-299731-sis9952k	378	22	protein	protein	NN
cord-299731-sis9952k	378	23	lysine	lysine	NN
cord-299731-sis9952k	378	24	acetylation	acetylation	NN
cord-299731-sis9952k	378	25	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	378	26	complex	complex	NN
cord-299731-sis9952k	379	1	I	-PRON-	PRP
cord-299731-sis9952k	379	2	deficiency	deficiency	NN
cord-299731-sis9952k	379	3	increases	increase	VBZ
cord-299731-sis9952k	379	4	protein	protein	NN
cord-299731-sis9952k	379	5	acetylation	acetylation	NN
cord-299731-sis9952k	379	6	and	and	CC
cord-299731-sis9952k	379	7	accelerates	accelerate	VBZ
cord-299731-sis9952k	379	8	heart	heart	NN
cord-299731-sis9952k	379	9	failure	failure	NN
cord-299731-sis9952k	379	10	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	379	11	Riboside	Riboside	NNP
cord-299731-sis9952k	379	12	Preserves	preserve	VBZ
cord-299731-sis9952k	379	13	Cardiac	Cardiac	NNP
cord-299731-sis9952k	379	14	Function	function	NN
cord-299731-sis9952k	379	15	in	in	IN
cord-299731-sis9952k	379	16	a	a	DT
cord-299731-sis9952k	379	17	Mouse	Mouse	NNP
cord-299731-sis9952k	379	18	Model	Model	NNP
cord-299731-sis9952k	379	19	of	of	IN
cord-299731-sis9952k	379	20	Dilated	dilated	JJ
cord-299731-sis9952k	379	21	Cardiomyopathy	Cardiomyopathy	NNP
cord-299731-sis9952k	379	22	Mechanisms	Mechanisms	NNPS
cord-299731-sis9952k	379	23	of	of	IN
cord-299731-sis9952k	379	24	altered	alter	VBN
cord-299731-sis9952k	379	25	Ca2	ca2	CD
cord-299731-sis9952k	380	1	+	+	CC
cord-299731-sis9952k	380	2	handling	handle	VBG
cord-299731-sis9952k	380	3	in	in	IN
cord-299731-sis9952k	380	4	heart	heart	NN
cord-299731-sis9952k	380	5	failure	failure	NN
cord-299731-sis9952k	380	6	Sirt1	Sirt1	NNP
cord-299731-sis9952k	380	7	regulates	regulate	VBZ
cord-299731-sis9952k	380	8	aging	age	VBG
cord-299731-sis9952k	380	9	and	and	CC
cord-299731-sis9952k	380	10	resistance	resistance	NN
cord-299731-sis9952k	380	11	to	to	IN
cord-299731-sis9952k	380	12	oxidative	oxidative	JJ
cord-299731-sis9952k	380	13	stress	stress	NN
cord-299731-sis9952k	380	14	in	in	IN
cord-299731-sis9952k	380	15	the	the	DT
cord-299731-sis9952k	380	16	heart	heart	NN
cord-299731-sis9952k	380	17	De	De	NNP
cord-299731-sis9952k	380	18	Angelis	Angelis	NNP
cord-299731-sis9952k	380	19	,	,	,
cord-299731-sis9952k	380	20	A.	a.	NN
cord-299731-sis9952k	380	21	;	;	.
cord-299731-sis9952k	381	1	Urbanek	Urbanek	NNS
cord-299731-sis9952k	381	2	,	,	,
cord-299731-sis9952k	382	1	K.	K.	NNP
cord-299731-sis9952k	382	2	SIRT1	SIRT1	NNP
cord-299731-sis9952k	382	3	activation	activation	NN
cord-299731-sis9952k	382	4	attenuates	attenuate	VBZ
cord-299731-sis9952k	382	5	diastolic	diastolic	JJ
cord-299731-sis9952k	382	6	dysfunction	dysfunction	NN
cord-299731-sis9952k	382	7	by	by	IN
cord-299731-sis9952k	382	8	reducing	reduce	VBG
cord-299731-sis9952k	382	9	cardiac	cardiac	JJ
cord-299731-sis9952k	382	10	fibrosis	fibrosis	NN
cord-299731-sis9952k	382	11	in	in	IN
cord-299731-sis9952k	382	12	a	a	DT
cord-299731-sis9952k	382	13	model	model	NN
cord-299731-sis9952k	382	14	of	of	IN
cord-299731-sis9952k	382	15	anthracycline	anthracycline	JJ
cord-299731-sis9952k	382	16	cardiomyopathy	cardiomyopathy	FW
cord-299731-sis9952k	382	17	SIRT1	SIRT1	NNP
cord-299731-sis9952k	382	18	Functions	function	NNS
cord-299731-sis9952k	382	19	as	as	IN
cord-299731-sis9952k	382	20	an	an	DT
cord-299731-sis9952k	382	21	Important	important	JJ
cord-299731-sis9952k	382	22	Regulator	regulator	NN
cord-299731-sis9952k	382	23	of	of	IN
cord-299731-sis9952k	382	24	Estrogen	Estrogen	NNP
cord-299731-sis9952k	382	25	-	-	HYPH
cord-299731-sis9952k	382	26	Mediated	mediate	VBN
cord-299731-sis9952k	382	27	Cardiomyocyte	Cardiomyocyte	NNP
cord-299731-sis9952k	382	28	Protection	Protection	NNP
cord-299731-sis9952k	382	29	in	in	IN
cord-299731-sis9952k	382	30	Angiotensin	Angiotensin	NNP
cord-299731-sis9952k	382	31	II	II	NNP
cord-299731-sis9952k	382	32	-	-	HYPH
cord-299731-sis9952k	382	33	Induced	induce	VBN
cord-299731-sis9952k	382	34	Heart	heart	NN
cord-299731-sis9952k	382	35	Hypertrophy	Hypertrophy	NNP
cord-299731-sis9952k	382	36	Protective	protective	JJ
cord-299731-sis9952k	382	37	effects	effect	NNS
cord-299731-sis9952k	382	38	of	of	IN
cord-299731-sis9952k	382	39	sirtuins	sirtuin	NNS
cord-299731-sis9952k	382	40	in	in	IN
cord-299731-sis9952k	382	41	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	382	42	diseases	disease	NNS
cord-299731-sis9952k	382	43	:	:	:
cord-299731-sis9952k	382	44	From	from	IN
cord-299731-sis9952k	382	45	bench	bench	NN
cord-299731-sis9952k	382	46	to	to	IN
cord-299731-sis9952k	382	47	bedside	bedside	NN
cord-299731-sis9952k	382	48	SIRT1	SIRT1	NNP
cord-299731-sis9952k	382	49	and	and	CC
cord-299731-sis9952k	382	50	SIRT6	SIRT6	NNP
cord-299731-sis9952k	383	1	signaling	signal	VBG
cord-299731-sis9952k	383	2	pathways	pathway	NNS
cord-299731-sis9952k	383	3	in	in	IN
cord-299731-sis9952k	383	4	cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	383	5	disease	disease	NN
cord-299731-sis9952k	383	6	protection	protection	NN
cord-299731-sis9952k	383	7	SIRT2	SIRT2	NNP
cord-299731-sis9952k	383	8	acts	act	VBZ
cord-299731-sis9952k	383	9	as	as	IN
cord-299731-sis9952k	383	10	a	a	DT
cord-299731-sis9952k	383	11	cardioprotective	cardioprotective	JJ
cord-299731-sis9952k	383	12	deacetylase	deacetylase	NN
cord-299731-sis9952k	383	13	in	in	IN
cord-299731-sis9952k	383	14	pathological	pathological	JJ
cord-299731-sis9952k	383	15	cardiac	cardiac	JJ
cord-299731-sis9952k	383	16	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	384	1	The	the	DT
cord-299731-sis9952k	384	2	sirtuin	sirtuin	NNP
cord-299731-sis9952k	384	3	SIRT6	SIRT6	NNP
cord-299731-sis9952k	385	1	blocks	block	NNS
cord-299731-sis9952k	386	1	IGF	IGF	NNP
cord-299731-sis9952k	386	2	-	-	HYPH
cord-299731-sis9952k	386	3	Akt	Akt	NNP
cord-299731-sis9952k	386	4	signaling	signaling	NN
cord-299731-sis9952k	386	5	and	and	CC
cord-299731-sis9952k	386	6	development	development	NN
cord-299731-sis9952k	386	7	of	of	IN
cord-299731-sis9952k	386	8	cardiac	cardiac	JJ
cord-299731-sis9952k	386	9	hypertrophy	hypertrophy	NN
cord-299731-sis9952k	386	10	by	by	IN
cord-299731-sis9952k	386	11	targeting	target	VBG
cord-299731-sis9952k	386	12	c	c	NN
cord-299731-sis9952k	386	13	-	-	:
cord-299731-sis9952k	386	14	Jun	Jun	NNP
cord-299731-sis9952k	386	15	Roles	Roles	NNPS
cord-299731-sis9952k	386	16	of	of	IN
cord-299731-sis9952k	386	17	SIRT3	SIRT3	NNS
cord-299731-sis9952k	386	18	in	in	IN
cord-299731-sis9952k	386	19	heart	heart	NN
cord-299731-sis9952k	386	20	failure	failure	NN
cord-299731-sis9952k	386	21	:	:	:
cord-299731-sis9952k	387	1	From	from	IN
cord-299731-sis9952k	387	2	bench	bench	NN
cord-299731-sis9952k	387	3	to	to	IN
cord-299731-sis9952k	387	4	bedside	bedside	NN
cord-299731-sis9952k	387	5	Pathways	Pathways	NNPS
cord-299731-sis9952k	387	6	and	and	CC
cord-299731-sis9952k	387	7	Subcellular	Subcellular	NNP
cord-299731-sis9952k	387	8	Compartmentation	Compartmentation	NNP
cord-299731-sis9952k	387	9	of	of	IN
cord-299731-sis9952k	387	10	NAD	NAD	NNP
cord-299731-sis9952k	387	11	Biosynthesis	Biosynthesis	NNP
cord-299731-sis9952k	387	12	in	in	IN
cord-299731-sis9952k	387	13	Human	Human	NNP
cord-299731-sis9952k	387	14	Cells	Cells	NNPS
cord-299731-sis9952k	387	15	Activation	Activation	NNP
cord-299731-sis9952k	387	16	of	of	IN
cord-299731-sis9952k	387	17	SIRT3	SIRT3	NNS
cord-299731-sis9952k	387	18	by	by	IN
cord-299731-sis9952k	387	19	the	the	DT
cord-299731-sis9952k	387	20	NAD+	NAD+	NNP
cord-299731-sis9952k	387	21	Precursor	Precursor	NNP
cord-299731-sis9952k	387	22	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	388	1	Riboside	riboside	NN
cord-299731-sis9952k	388	2	Protects	protect	VBZ
cord-299731-sis9952k	388	3	from	from	IN
cord-299731-sis9952k	388	4	Noise	noise	NN
cord-299731-sis9952k	388	5	-	-	HYPH
cord-299731-sis9952k	388	6	Induced	induce	VBN
cord-299731-sis9952k	388	7	Hearing	Hearing	NNP
cord-299731-sis9952k	388	8	Loss	Loss	NNP
cord-299731-sis9952k	388	9	Boosting	boost	VBG
cord-299731-sis9952k	388	10	NAD	NAD	NNP
cord-299731-sis9952k	388	11	to	to	IN
cord-299731-sis9952k	388	12	Spare	spare	VB
cord-299731-sis9952k	388	13	Hearing	hearing	NN
cord-299731-sis9952k	389	1	Arterial	arterial	JJ
cord-299731-sis9952k	389	2	and	and	CC
cord-299731-sis9952k	389	3	Cardiac	Cardiac	NNP
cord-299731-sis9952k	389	4	Aging	aging	NN
cord-299731-sis9952k	389	5	:	:	:
cord-299731-sis9952k	390	1	Major	Major	NNP
cord-299731-sis9952k	390	2	Shareholders	Shareholders	NNPS
cord-299731-sis9952k	390	3	in	in	IN
cord-299731-sis9952k	390	4	Cardiovascular	Cardiovascular	NNP
cord-299731-sis9952k	390	5	Disease	Disease	NNP
cord-299731-sis9952k	390	6	Enterprises	Enterprises	NNP
cord-299731-sis9952k	390	7	Seventh	Seventh	NNP
cord-299731-sis9952k	390	8	Report	Report	NNP
cord-299731-sis9952k	390	9	of	of	IN
cord-299731-sis9952k	390	10	the	the	DT
cord-299731-sis9952k	390	11	Joint	Joint	NNP
cord-299731-sis9952k	390	12	National	National	NNP
cord-299731-sis9952k	390	13	Committee	Committee	NNP
cord-299731-sis9952k	390	14	on	on	IN
cord-299731-sis9952k	390	15	Prevention	Prevention	NNP
cord-299731-sis9952k	390	16	,	,	,
cord-299731-sis9952k	390	17	Detection	Detection	NNP
cord-299731-sis9952k	390	18	,	,	,
cord-299731-sis9952k	390	19	Evaluation	Evaluation	NNP
cord-299731-sis9952k	390	20	,	,	,
cord-299731-sis9952k	390	21	and	and	CC
cord-299731-sis9952k	390	22	Treatment	Treatment	NNP
cord-299731-sis9952k	390	23	of	of	IN
cord-299731-sis9952k	390	24	High	High	NNP
cord-299731-sis9952k	390	25	Blood	Blood	NNP
cord-299731-sis9952k	390	26	Pressure	Pressure	NNP
cord-299731-sis9952k	390	27	and	and	CC
cord-299731-sis9952k	390	28	Evidence	evidence	NN
cord-299731-sis9952k	390	29	from	from	IN
cord-299731-sis9952k	390	30	New	New	NNP
cord-299731-sis9952k	390	31	Hypertension	Hypertension	NNP
cord-299731-sis9952k	390	32	Trials	Trials	NNPS
cord-299731-sis9952k	390	33	Life	life	NN
cord-299731-sis9952k	390	34	-	-	HYPH
cord-299731-sis9952k	390	35	long	long	JJ
cord-299731-sis9952k	390	36	caloric	caloric	JJ
cord-299731-sis9952k	390	37	restriction	restriction	NN
cord-299731-sis9952k	390	38	reduces	reduce	VBZ
cord-299731-sis9952k	390	39	oxidative	oxidative	JJ
cord-299731-sis9952k	390	40	stress	stress	NN
cord-299731-sis9952k	390	41	and	and	CC
cord-299731-sis9952k	390	42	preserves	preserve	VBZ
cord-299731-sis9952k	390	43	nitric	nitric	NN
cord-299731-sis9952k	390	44	oxide	oxide	NN
cord-299731-sis9952k	390	45	bioavailability	bioavailability	NN
cord-299731-sis9952k	390	46	and	and	CC
cord-299731-sis9952k	390	47	function	function	VB
cord-299731-sis9952k	390	48	in	in	IN
cord-299731-sis9952k	390	49	arteries	artery	NNS
cord-299731-sis9952k	390	50	of	of	IN
cord-299731-sis9952k	390	51	old	old	JJ
cord-299731-sis9952k	390	52	mice	mice	NN
cord-299731-sis9952k	390	53	SIRT-1	SIRT-1	NNS
cord-299731-sis9952k	390	54	and	and	CC
cord-299731-sis9952k	390	55	vascular	vascular	JJ
cord-299731-sis9952k	390	56	endothelial	endothelial	JJ
cord-299731-sis9952k	390	57	dysfunction	dysfunction	NN
cord-299731-sis9952k	390	58	with	with	IN
cord-299731-sis9952k	390	59	ageing	age	VBG
cord-299731-sis9952k	390	60	in	in	IN
cord-299731-sis9952k	390	61	mice	mouse	NNS
cord-299731-sis9952k	390	62	and	and	CC
cord-299731-sis9952k	390	63	humans	human	NNS
cord-299731-sis9952k	390	64	SIRT1	SIRT1	NNP
cord-299731-sis9952k	390	65	promotes	promote	VBZ
cord-299731-sis9952k	390	66	endothelium	endothelium	NN
cord-299731-sis9952k	390	67	-	-	HYPH
cord-299731-sis9952k	390	68	dependent	dependent	JJ
cord-299731-sis9952k	390	69	vascular	vascular	JJ
cord-299731-sis9952k	390	70	relaxation	relaxation	NN
cord-299731-sis9952k	390	71	by	by	IN
cord-299731-sis9952k	390	72	activating	activate	VBG
cord-299731-sis9952k	390	73	endothelial	endothelial	JJ
cord-299731-sis9952k	390	74	nitric	nitric	JJ
cord-299731-sis9952k	390	75	oxide	oxide	NN
cord-299731-sis9952k	390	76	synthase	synthase	NN
cord-299731-sis9952k	390	77	Regulation	regulation	NN
cord-299731-sis9952k	390	78	of	of	IN
cord-299731-sis9952k	390	79	Akt	Akt	NNP
cord-299731-sis9952k	391	1	Signaling	signal	VBG
cord-299731-sis9952k	391	2	by	by	IN
cord-299731-sis9952k	391	3	Sirtuins	Sirtuins	NNP
cord-299731-sis9952k	391	4	Genome	Genome	NNP
cord-299731-sis9952k	391	5	instability	instability	NN
cord-299731-sis9952k	391	6	in	in	IN
cord-299731-sis9952k	391	7	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	391	8	disease	disease	NN
cord-299731-sis9952k	391	9	Genomic	genomic	JJ
cord-299731-sis9952k	391	10	integrity	integrity	NN
cord-299731-sis9952k	391	11	and	and	CC
cord-299731-sis9952k	391	12	the	the	DT
cord-299731-sis9952k	391	13	ageing	age	VBG
cord-299731-sis9952k	391	14	brain	brain	NN
cord-299731-sis9952k	391	15	Mitophagy	Mitophagy	NNP
cord-299731-sis9952k	391	16	and	and	CC
cord-299731-sis9952k	391	17	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	391	18	's	's	POS
cord-299731-sis9952k	391	19	Disease	Disease	NNP
cord-299731-sis9952k	391	20	:	:	:
cord-299731-sis9952k	391	21	Cellular	Cellular	NNP
cord-299731-sis9952k	391	22	and	and	CC
cord-299731-sis9952k	391	23	Molecular	Molecular	NNP
cord-299731-sis9952k	391	24	Mechanisms	Mechanisms	NNPS
cord-299731-sis9952k	391	25	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	391	26	riboside	riboside	NN
cord-299731-sis9952k	391	27	restores	restore	VBZ
cord-299731-sis9952k	391	28	cognition	cognition	NN
cord-299731-sis9952k	391	29	through	through	IN
cord-299731-sis9952k	391	30	an	an	DT
cord-299731-sis9952k	391	31	upregulation	upregulation	NN
cord-299731-sis9952k	391	32	of	of	IN
cord-299731-sis9952k	391	33	proliferator	proliferator	NN
cord-299731-sis9952k	391	34	-	-	HYPH
cord-299731-sis9952k	391	35	activated	activate	VBN
cord-299731-sis9952k	391	36	receptor	receptor	NN
cord-299731-sis9952k	391	37	-	-	HYPH
cord-299731-sis9952k	391	38	γ	γ	NN
cord-299731-sis9952k	391	39	coactivator	coactivator	NN
cord-299731-sis9952k	391	40	1α	1α	CD
cord-299731-sis9952k	391	41	regulated	regulate	VBD
cord-299731-sis9952k	391	42	β	β	NNP
cord-299731-sis9952k	391	43	-	-	HYPH
cord-299731-sis9952k	391	44	secretase	secretase	NNP
cord-299731-sis9952k	391	45	1	1	CD
cord-299731-sis9952k	391	46	degradation	degradation	NN
cord-299731-sis9952k	391	47	and	and	CC
cord-299731-sis9952k	391	48	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	391	49	gene	gene	NN
cord-299731-sis9952k	391	50	expression	expression	NN
cord-299731-sis9952k	391	51	in	in	IN
cord-299731-sis9952k	391	52	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	391	53	's	's	POS
cord-299731-sis9952k	391	54	mouse	mouse	NN
cord-299731-sis9952k	391	55	models	model	NNS
cord-299731-sis9952k	392	1	Increased	increase	VBN
cord-299731-sis9952k	392	2	poly(ADP	poly(ADP	NNP
cord-299731-sis9952k	392	3	-	-	HYPH
cord-299731-sis9952k	392	4	ribosyl)ation	ribosyl)ation	NNP
cord-299731-sis9952k	392	5	of	of	IN
cord-299731-sis9952k	392	6	nuclear	nuclear	JJ
cord-299731-sis9952k	392	7	proteins	protein	NNS
cord-299731-sis9952k	392	8	in	in	IN
cord-299731-sis9952k	392	9	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	392	10	's	's	POS
cord-299731-sis9952k	392	11	disease	disease	NN
cord-299731-sis9952k	393	1	NAD+	NAD+	NNP
cord-299731-sis9952k	393	2	supplementation	supplementation	NN
cord-299731-sis9952k	393	3	normalizes	normalize	VBZ
cord-299731-sis9952k	393	4	key	key	JJ
cord-299731-sis9952k	393	5	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	393	6	's	's	POS
cord-299731-sis9952k	393	7	features	feature	NNS
cord-299731-sis9952k	393	8	and	and	CC
cord-299731-sis9952k	393	9	DNA	dna	NN
cord-299731-sis9952k	393	10	damage	damage	NN
cord-299731-sis9952k	393	11	responses	response	NNS
cord-299731-sis9952k	393	12	in	in	IN
cord-299731-sis9952k	393	13	a	a	DT
cord-299731-sis9952k	393	14	new	new	JJ
cord-299731-sis9952k	393	15	AD	ad	NN
cord-299731-sis9952k	393	16	mouse	mouse	NN
cord-299731-sis9952k	393	17	model	model	NN
cord-299731-sis9952k	393	18	with	with	IN
cord-299731-sis9952k	393	19	introduced	introduce	VBN
cord-299731-sis9952k	393	20	DNA	dna	NN
cord-299731-sis9952k	393	21	repair	repair	NN
cord-299731-sis9952k	393	22	deficiency	deficiency	NN
cord-299731-sis9952k	393	23	Supplementation	supplementation	NN
cord-299731-sis9952k	393	24	with	with	IN
cord-299731-sis9952k	393	25	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	393	26	Riboside	Riboside	NNP
cord-299731-sis9952k	393	27	Reduces	reduce	VBZ
cord-299731-sis9952k	393	28	Brain	Brain	NNP
cord-299731-sis9952k	393	29	Inflammation	inflammation	NN
cord-299731-sis9952k	393	30	and	and	CC
cord-299731-sis9952k	393	31	Improves	improve	VBZ
cord-299731-sis9952k	393	32	Cognitive	Cognitive	NNP
cord-299731-sis9952k	393	33	Function	Function	NNP
cord-299731-sis9952k	393	34	in	in	IN
cord-299731-sis9952k	393	35	Diabetic	diabetic	JJ
cord-299731-sis9952k	393	36	Mice	Mice	NNP
cord-299731-sis9952k	393	37	Inflammation	Inflammation	NNP
cord-299731-sis9952k	393	38	and	and	CC
cord-299731-sis9952k	393	39	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	393	40	's	's	POS
cord-299731-sis9952k	393	41	disease	disease	NN
cord-299731-sis9952k	393	42	Association	Association	NNP
cord-299731-sis9952k	393	43	between	between	IN
cord-299731-sis9952k	393	44	raised	raise	VBD
cord-299731-sis9952k	393	45	inflammatory	inflammatory	JJ
cord-299731-sis9952k	393	46	markers	marker	NNS
cord-299731-sis9952k	393	47	and	and	CC
cord-299731-sis9952k	393	48	cognitive	cognitive	JJ
cord-299731-sis9952k	393	49	decline	decline	NN
cord-299731-sis9952k	393	50	in	in	IN
cord-299731-sis9952k	393	51	elderly	elderly	JJ
cord-299731-sis9952k	393	52	people	people	NNS
cord-299731-sis9952k	393	53	with	with	IN
cord-299731-sis9952k	393	54	type	type	NN
cord-299731-sis9952k	393	55	2	2	CD
cord-299731-sis9952k	393	56	diabetes	diabetes	NN
cord-299731-sis9952k	393	57	:	:	:
cord-299731-sis9952k	394	1	The	the	DT
cord-299731-sis9952k	394	2	Edinburgh	Edinburgh	NNP
cord-299731-sis9952k	394	3	Type	Type	NNP
cord-299731-sis9952k	394	4	2	2	CD
cord-299731-sis9952k	394	5	Diabetes	Diabetes	NNP
cord-299731-sis9952k	394	6	Study	Study	NNP
cord-299731-sis9952k	394	7	Activation	Activation	NNP
cord-299731-sis9952k	394	8	of	of	IN
cord-299731-sis9952k	394	9	Hippocampal	Hippocampal	NNP
cord-299731-sis9952k	394	10	CREB	CREB	NNP
cord-299731-sis9952k	394	11	by	by	IN
cord-299731-sis9952k	394	12	Rolipram	Rolipram	NNP
cord-299731-sis9952k	394	13	Partially	Partially	NNP
cord-299731-sis9952k	394	14	Recovers	recover	VBZ
cord-299731-sis9952k	394	15	Balance	Balance	NNP
cord-299731-sis9952k	394	16	Between	between	IN
cord-299731-sis9952k	394	17	TNF	tnf	NN
cord-299731-sis9952k	394	18	-	-	HYPH
cord-299731-sis9952k	394	19	alpha	alpha	NN
cord-299731-sis9952k	394	20	and	and	CC
cord-299731-sis9952k	394	21	IL-10	IL-10	NNP
cord-299731-sis9952k	394	22	Levels	Levels	NNPS
cord-299731-sis9952k	394	23	and	and	CC
cord-299731-sis9952k	394	24	Improves	improve	VBZ
cord-299731-sis9952k	394	25	Cognitive	cognitive	JJ
cord-299731-sis9952k	394	26	Deficits	deficit	NNS
cord-299731-sis9952k	394	27	in	in	IN
cord-299731-sis9952k	394	28	Diabetic	diabetic	JJ
cord-299731-sis9952k	394	29	Rats	Rats	NNP
cord-299731-sis9952k	394	30	NAD	NAD	NNP
cord-299731-sis9952k	395	1	+	+	CC
cord-299731-sis9952k	396	1	Replenishment	replenishment	NN
cord-299731-sis9952k	396	2	Improves	improve	VBZ
cord-299731-sis9952k	396	3	Lifespan	Lifespan	NNP
cord-299731-sis9952k	396	4	and	and	CC
cord-299731-sis9952k	396	5	Healthspan	Healthspan	NNP
cord-299731-sis9952k	396	6	in	in	IN
cord-299731-sis9952k	396	7	Ataxia	Ataxia	NNP
cord-299731-sis9952k	396	8	Telangiectasia	Telangiectasia	NNP
cord-299731-sis9952k	396	9	Models	Models	NNPS
cord-299731-sis9952k	396	10	via	via	IN
cord-299731-sis9952k	396	11	Mitophagy	Mitophagy	NNP
cord-299731-sis9952k	396	12	and	and	CC
cord-299731-sis9952k	396	13	DNA	DNA	NNP
cord-299731-sis9952k	396	14	Repair	Repair	NNP
cord-299731-sis9952k	397	1	A	a	DT
cord-299731-sis9952k	397	2	High	high	JJ
cord-299731-sis9952k	397	3	-	-	HYPH
cord-299731-sis9952k	397	4	Fat	Fat	NNP
cord-299731-sis9952k	397	5	Diet	Diet	NNP
cord-299731-sis9952k	397	6	and	and	CC
cord-299731-sis9952k	397	7	NAD	NAD	NNP
cord-299731-sis9952k	398	1	+	+	CC
cord-299731-sis9952k	398	2	Activate	activate	VB
cord-299731-sis9952k	398	3	Sirt1	Sirt1	NNS
cord-299731-sis9952k	399	1	to	to	IN
cord-299731-sis9952k	399	2	Rescue	Rescue	NNP
cord-299731-sis9952k	399	3	Premature	premature	JJ
cord-299731-sis9952k	399	4	Aging	age	VBG
cord-299731-sis9952k	399	5	in	in	IN
cord-299731-sis9952k	399	6	Cockayne	Cockayne	NNP
cord-299731-sis9952k	399	7	Syndrome	Syndrome	NNP
cord-299731-sis9952k	400	1	Acquired	acquire	VBN
cord-299731-sis9952k	400	2	axonal	axonal	JJ
cord-299731-sis9952k	400	3	degeneration	degeneration	NN
cord-299731-sis9952k	400	4	and	and	CC
cord-299731-sis9952k	400	5	regeneration	regeneration	NN
cord-299731-sis9952k	400	6	:	:	:
cord-299731-sis9952k	401	1	Recent	recent	JJ
cord-299731-sis9952k	401	2	insights	insight	NNS
cord-299731-sis9952k	401	3	and	and	CC
cord-299731-sis9952k	401	4	clinical	clinical	JJ
cord-299731-sis9952k	401	5	correlations	correlation	NNS
cord-299731-sis9952k	402	1	Axon	axon	NN
cord-299731-sis9952k	402	2	degeneration	degeneration	NN
cord-299731-sis9952k	402	3	in	in	IN
cord-299731-sis9952k	402	4	Parkinson	Parkinson	NNP
cord-299731-sis9952k	402	5	's	's	POS
cord-299731-sis9952k	402	6	disease	disease	NN
cord-299731-sis9952k	402	7	Axonal	Axonal	NNP
cord-299731-sis9952k	402	8	degeneration	degeneration	NN
cord-299731-sis9952k	402	9	in	in	IN
cord-299731-sis9952k	402	10	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	402	11	's	's	POS
cord-299731-sis9952k	402	12	disease	disease	NN
cord-299731-sis9952k	402	13	:	:	:
cord-299731-sis9952k	402	14	When	when	WRB
cord-299731-sis9952k	402	15	signaling	signal	VBG
cord-299731-sis9952k	402	16	abnormalities	abnormality	NNS
cord-299731-sis9952k	402	17	meet	meet	VBP
cord-299731-sis9952k	402	18	the	the	DT
cord-299731-sis9952k	402	19	axonal	axonal	JJ
cord-299731-sis9952k	402	20	transport	transport	NN
cord-299731-sis9952k	402	21	system	system	NN
cord-299731-sis9952k	402	22	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	402	23	's	's	POS
cord-299731-sis9952k	402	24	disease	disease	NN
cord-299731-sis9952k	402	25	is	be	VBZ
cord-299731-sis9952k	402	26	a	a	DT
cord-299731-sis9952k	402	27	synaptic	synaptic	JJ
cord-299731-sis9952k	402	28	failure	failure	NN
cord-299731-sis9952k	403	1	Neuronal	neuronal	JJ
cord-299731-sis9952k	403	2	Sirt3	Sirt3	NNS
cord-299731-sis9952k	403	3	Protects	protect	VBZ
cord-299731-sis9952k	403	4	against	against	IN
cord-299731-sis9952k	403	5	Excitotoxic	Excitotoxic	NNP
cord-299731-sis9952k	403	6	Injury	Injury	NNP
cord-299731-sis9952k	403	7	in	in	IN
cord-299731-sis9952k	403	8	Mouse	Mouse	NNP
cord-299731-sis9952k	403	9	Cortical	Cortical	NNP
cord-299731-sis9952k	403	10	Neuron	Neuron	NNP
cord-299731-sis9952k	403	11	Culture	culture	NN
cord-299731-sis9952k	404	1	Preventing	prevent	VBG
cord-299731-sis9952k	404	2	NAD+	NAD+	NNP
cord-299731-sis9952k	404	3	Depletion	Depletion	NNP
cord-299731-sis9952k	404	4	Protects	protect	VBZ
cord-299731-sis9952k	404	5	Neurons	Neurons	NNPS
cord-299731-sis9952k	404	6	against	against	IN
cord-299731-sis9952k	404	7	Excitotoxicity	Excitotoxicity	NNP
cord-299731-sis9952k	404	8	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	404	9	prevents	prevent	VBZ
cord-299731-sis9952k	404	10	NAD+	NAD+	NNP
cord-299731-sis9952k	404	11	depletion	depletion	NN
cord-299731-sis9952k	404	12	and	and	CC
cord-299731-sis9952k	404	13	protects	protect	VBZ
cord-299731-sis9952k	404	14	neurons	neuron	NNS
cord-299731-sis9952k	404	15	against	against	IN
cord-299731-sis9952k	404	16	excitotoxicity	excitotoxicity	NN
cord-299731-sis9952k	404	17	and	and	CC
cord-299731-sis9952k	404	18	cerebral	cerebral	JJ
cord-299731-sis9952k	404	19	ischemia	ischemia	NN
cord-299731-sis9952k	404	20	:	:	:
cord-299731-sis9952k	405	1	NAD+	NAD+	NNP
cord-299731-sis9952k	406	1	consumption	consumption	NN
cord-299731-sis9952k	406	2	by	by	IN
cord-299731-sis9952k	406	3	SIRT1	SIRT1	NNS
cord-299731-sis9952k	406	4	may	may	MD
cord-299731-sis9952k	406	5	endanger	endanger	VB
cord-299731-sis9952k	406	6	energetically	energetically	RB
cord-299731-sis9952k	406	7	compromised	compromise	VBN
cord-299731-sis9952k	406	8	neurons	neuron	NNS
cord-299731-sis9952k	407	1	Neuronal	neuronal	JJ
cord-299731-sis9952k	407	2	protective	protective	JJ
cord-299731-sis9952k	407	3	role	role	NN
cord-299731-sis9952k	407	4	of	of	IN
cord-299731-sis9952k	407	5	PBEF	PBEF	NNP
cord-299731-sis9952k	407	6	in	in	IN
cord-299731-sis9952k	407	7	a	a	DT
cord-299731-sis9952k	407	8	mouse	mouse	NN
cord-299731-sis9952k	407	9	model	model	NN
cord-299731-sis9952k	407	10	of	of	IN
cord-299731-sis9952k	407	11	cerebral	cerebral	JJ
cord-299731-sis9952k	407	12	ischemia	ischemia	NN
cord-299731-sis9952k	407	13	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	407	14	riboside	riboside	NN
cord-299731-sis9952k	407	15	,	,	,
cord-299731-sis9952k	407	16	a	a	DT
cord-299731-sis9952k	407	17	form	form	NN
cord-299731-sis9952k	407	18	of	of	IN
cord-299731-sis9952k	407	19	vitamin	vitamin	NN
cord-299731-sis9952k	407	20	B3	b3	NN
cord-299731-sis9952k	407	21	,	,	,
cord-299731-sis9952k	407	22	protects	protect	VBZ
cord-299731-sis9952k	407	23	against	against	IN
cord-299731-sis9952k	407	24	excitotoxicity	excitotoxicity	NN
cord-299731-sis9952k	407	25	-	-	HYPH
cord-299731-sis9952k	407	26	induced	induce	VBN
cord-299731-sis9952k	407	27	axonal	axonal	JJ
cord-299731-sis9952k	407	28	degeneration	degeneration	NN
cord-299731-sis9952k	407	29	Stimulation	stimulation	NN
cord-299731-sis9952k	407	30	of	of	IN
cord-299731-sis9952k	407	31	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	407	32	adenine	adenine	NN
cord-299731-sis9952k	407	33	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	407	34	biosynthetic	biosynthetic	JJ
cord-299731-sis9952k	407	35	pathways	pathway	NNS
cord-299731-sis9952k	407	36	delays	delay	NNS
cord-299731-sis9952k	407	37	axonal	axonal	JJ
cord-299731-sis9952k	407	38	degeneration	degeneration	NN
cord-299731-sis9952k	407	39	after	after	IN
cord-299731-sis9952k	407	40	axotomy	axotomy	,
cord-299731-sis9952k	407	41	SARM1	SARM1	NNP
cord-299731-sis9952k	407	42	activation	activation	NN
cord-299731-sis9952k	407	43	triggers	trigger	VBZ
cord-299731-sis9952k	407	44	axon	axon	NN
cord-299731-sis9952k	407	45	degeneration	degeneration	NN
cord-299731-sis9952k	407	46	locally	locally	RB
cord-299731-sis9952k	407	47	via	via	IN
cord-299731-sis9952k	407	48	NAD+	NAD+	NNP
cord-299731-sis9952k	407	49	destruction	destruction	NN
cord-299731-sis9952k	408	1	NAMPT	NAMPT	NNP
cord-299731-sis9952k	408	2	-	-	HYPH
cord-299731-sis9952k	408	3	Mediated	mediate	VBN
cord-299731-sis9952k	408	4	NAD+	NAD+	NNP
cord-299731-sis9952k	409	1	Biosynthesis	Biosynthesis	NNP
cord-299731-sis9952k	409	2	Is	be	VBZ
cord-299731-sis9952k	409	3	Essential	essential	JJ
cord-299731-sis9952k	409	4	for	for	IN
cord-299731-sis9952k	409	5	Vision	vision	NN
cord-299731-sis9952k	409	6	in	in	IN
cord-299731-sis9952k	409	7	Mice	Mice	NNP
cord-299731-sis9952k	409	8	NAD+-Dependent	NAD+-Dependent	NNP
cord-299731-sis9952k	409	9	Activation	Activation	NNP
cord-299731-sis9952k	409	10	of	of	IN
cord-299731-sis9952k	409	11	Sirt1	Sirt1	NNP
cord-299731-sis9952k	410	1	Corrects	correct	VBZ
cord-299731-sis9952k	410	2	the	the	DT
cord-299731-sis9952k	410	3	Phenotype	Phenotype	NNP
cord-299731-sis9952k	410	4	in	in	IN
cord-299731-sis9952k	410	5	a	a	DT
cord-299731-sis9952k	410	6	Mouse	Mouse	NNP
cord-299731-sis9952k	410	7	Model	Model	NNP
cord-299731-sis9952k	410	8	of	of	IN
cord-299731-sis9952k	410	9	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	410	10	Disease	Disease	NNP
cord-299731-sis9952k	410	11	Effective	effective	JJ
cord-299731-sis9952k	410	12	treatment	treatment	NN
cord-299731-sis9952k	410	13	of	of	IN
cord-299731-sis9952k	410	14	mitochondrial	mitochondrial	JJ
cord-299731-sis9952k	410	15	myopathy	myopathy	NN
cord-299731-sis9952k	410	16	by	by	IN
cord-299731-sis9952k	410	17	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	410	18	riboside	riboside	NN
cord-299731-sis9952k	410	19	,	,	,
cord-299731-sis9952k	410	20	a	a	DT
cord-299731-sis9952k	410	21	vitamin	vitamin	NN
cord-299731-sis9952k	410	22	B3	b3	NN
cord-299731-sis9952k	410	23	Loss	loss	NN
cord-299731-sis9952k	410	24	of	of	IN
cord-299731-sis9952k	410	25	NAD	NAD	NNP
cord-299731-sis9952k	410	26	Homeostasis	Homeostasis	NNP
cord-299731-sis9952k	410	27	Leads	lead	VBZ
cord-299731-sis9952k	410	28	to	to	IN
cord-299731-sis9952k	410	29	Progressive	progressive	JJ
cord-299731-sis9952k	410	30	and	and	CC
cord-299731-sis9952k	410	31	Reversible	reversible	JJ
cord-299731-sis9952k	410	32	Degeneration	Degeneration	NNP
cord-299731-sis9952k	410	33	of	of	IN
cord-299731-sis9952k	410	34	Skeletal	skeletal	JJ
cord-299731-sis9952k	410	35	Muscle	muscle	NN
cord-299731-sis9952k	410	36	NAD+	NAD+	NNP
cord-299731-sis9952k	410	37	repletion	repletion	NN
cord-299731-sis9952k	410	38	improves	improve	VBZ
cord-299731-sis9952k	410	39	muscle	muscle	NN
cord-299731-sis9952k	410	40	function	function	NN
cord-299731-sis9952k	410	41	in	in	IN
cord-299731-sis9952k	410	42	muscular	muscular	JJ
cord-299731-sis9952k	410	43	dystrophy	dystrophy	NN
cord-299731-sis9952k	410	44	and	and	CC
cord-299731-sis9952k	410	45	counters	counter	VBZ
cord-299731-sis9952k	410	46	global	global	JJ
cord-299731-sis9952k	410	47	PARylation	parylation	NN
cord-299731-sis9952k	410	48	Muscle	muscle	NN
cord-299731-sis9952k	410	49	-	-	HYPH
cord-299731-sis9952k	410	50	Specific	specific	JJ
cord-299731-sis9952k	410	51	SIRT1	sirt1	NN
cord-299731-sis9952k	410	52	Gain	gain	NN
cord-299731-sis9952k	410	53	-	-	HYPH
cord-299731-sis9952k	410	54	of	of	IN
cord-299731-sis9952k	410	55	-	-	HYPH
cord-299731-sis9952k	410	56	Function	function	NN
cord-299731-sis9952k	410	57	Increases	increase	VBZ
cord-299731-sis9952k	410	58	Slow	slow	JJ
cord-299731-sis9952k	410	59	-	-	HYPH
cord-299731-sis9952k	410	60	Twitch	twitch	NN
cord-299731-sis9952k	410	61	Fibers	Fibers	NNPS
cord-299731-sis9952k	410	62	and	and	CC
cord-299731-sis9952k	410	63	Ameliorates	Ameliorates	NNPS
cord-299731-sis9952k	410	64	Pathophysiology	Pathophysiology	NNP
cord-299731-sis9952k	410	65	in	in	IN
cord-299731-sis9952k	410	66	a	a	DT
cord-299731-sis9952k	410	67	Mouse	Mouse	NNP
cord-299731-sis9952k	410	68	Model	Model	NNP
cord-299731-sis9952k	410	69	of	of	IN
cord-299731-sis9952k	410	70	Duchenne	Duchenne	NNP
cord-299731-sis9952k	410	71	Muscular	Muscular	NNP
cord-299731-sis9952k	410	72	Dystrophy	Dystrophy	NNP
cord-299731-sis9952k	410	73	Requirement	Requirement	NNP
cord-299731-sis9952k	410	74	of	of	IN
cord-299731-sis9952k	410	75	NAD+	NAD+	NNP
cord-299731-sis9952k	410	76	and	and	CC
cord-299731-sis9952k	410	77	SIR2	SIR2	NNP
cord-299731-sis9952k	410	78	for	for	IN
cord-299731-sis9952k	410	79	life	life	NN
cord-299731-sis9952k	410	80	-	-	HYPH
cord-299731-sis9952k	410	81	span	span	NN
cord-299731-sis9952k	410	82	extension	extension	NN
cord-299731-sis9952k	410	83	by	by	IN
cord-299731-sis9952k	410	84	calorie	calorie	NN
cord-299731-sis9952k	410	85	restriction	restriction	NN
cord-299731-sis9952k	410	86	in	in	IN
cord-299731-sis9952k	410	87	Saccharomyces	Saccharomyces	NNP
cord-299731-sis9952k	410	88	cerevisiae	cerevisiae	VBZ
cord-299731-sis9952k	410	89	Manipulation	manipulation	NN
cord-299731-sis9952k	410	90	of	of	IN
cord-299731-sis9952k	410	91	a	a	DT
cord-299731-sis9952k	410	92	nuclear	nuclear	JJ
cord-299731-sis9952k	410	93	NAD+	NAD+	NNP
cord-299731-sis9952k	410	94	salvage	salvage	NN
cord-299731-sis9952k	410	95	pathway	pathway	NN
cord-299731-sis9952k	410	96	delays	delay	NNS
cord-299731-sis9952k	410	97	aging	age	VBG
cord-299731-sis9952k	410	98	without	without	IN
cord-299731-sis9952k	410	99	altering	alter	VBG
cord-299731-sis9952k	410	100	steady	steady	JJ
cord-299731-sis9952k	410	101	-	-	HYPH
cord-299731-sis9952k	410	102	state	state	NN
cord-299731-sis9952k	410	103	NAD+	NAD+	NNP
cord-299731-sis9952k	410	104	levels	level	NNS
cord-299731-sis9952k	410	105	Inhibition	inhibition	NN
cord-299731-sis9952k	410	106	of	of	IN
cord-299731-sis9952k	410	107	silencing	silencing	NN
cord-299731-sis9952k	410	108	and	and	CC
cord-299731-sis9952k	410	109	accelerated	accelerated	JJ
cord-299731-sis9952k	410	110	aging	age	VBG
cord-299731-sis9952k	410	111	by	by	IN
cord-299731-sis9952k	410	112	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	410	113	,	,	,
cord-299731-sis9952k	410	114	a	a	DT
cord-299731-sis9952k	410	115	putative	putative	JJ
cord-299731-sis9952k	410	116	negative	negative	JJ
cord-299731-sis9952k	410	117	regulator	regulator	NN
cord-299731-sis9952k	410	118	of	of	IN
cord-299731-sis9952k	410	119	yeast	yeast	NN
cord-299731-sis9952k	410	120	Sir2	Sir2	NNP
cord-299731-sis9952k	410	121	and	and	CC
cord-299731-sis9952k	410	122	human	human	JJ
cord-299731-sis9952k	410	123	SIRT1	sirt1	NN
cord-299731-sis9952k	410	124	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	410	125	Clearance	Clearance	NNP
cord-299731-sis9952k	410	126	by	by	IN
cord-299731-sis9952k	410	127	Pnc1	Pnc1	NNP
cord-299731-sis9952k	411	1	Directly	directly	RB
cord-299731-sis9952k	411	2	Regulates	regulate	VBZ
cord-299731-sis9952k	411	3	Sir2-Mediated	Sir2-Mediated	NNP
cord-299731-sis9952k	411	4	Silencing	Silencing	NNP
cord-299731-sis9952k	411	5	and	and	CC
cord-299731-sis9952k	411	6	Longevity	Longevity	NNP
cord-299731-sis9952k	411	7	Nutrient	Nutrient	NNP
cord-299731-sis9952k	411	8	control	control	NN
cord-299731-sis9952k	411	9	of	of	IN
cord-299731-sis9952k	411	10	glucose	glucose	NN
cord-299731-sis9952k	411	11	homeostasis	homeostasis	NN
cord-299731-sis9952k	411	12	through	through	IN
cord-299731-sis9952k	411	13	a	a	DT
cord-299731-sis9952k	411	14	complex	complex	NN
cord-299731-sis9952k	411	15	of	of	IN
cord-299731-sis9952k	411	16	PGC-1alpha	pgc-1alpha	NN
cord-299731-sis9952k	411	17	and	and	CC
cord-299731-sis9952k	411	18	SIRT1	sirt1	VB
cord-299731-sis9952k	411	19	Neuronal	neuronal	JJ
cord-299731-sis9952k	411	20	SIRT1	sirt1	NN
cord-299731-sis9952k	411	21	activation	activation	NN
cord-299731-sis9952k	411	22	as	as	IN
cord-299731-sis9952k	411	23	a	a	DT
cord-299731-sis9952k	411	24	novel	novel	NN
cord-299731-sis9952k	411	25	mechanism	mechanism	NN
cord-299731-sis9952k	411	26	underlying	underlie	VBG
cord-299731-sis9952k	411	27	the	the	DT
cord-299731-sis9952k	411	28	prevention	prevention	NN
cord-299731-sis9952k	411	29	of	of	IN
cord-299731-sis9952k	411	30	Alzheimer	Alzheimer	NNP
cord-299731-sis9952k	411	31	disease	disease	NN
cord-299731-sis9952k	411	32	amyloid	amyloid	NN
cord-299731-sis9952k	411	33	neuropathology	neuropathology	NN
cord-299731-sis9952k	411	34	by	by	IN
cord-299731-sis9952k	411	35	calorie	calorie	NN
cord-299731-sis9952k	411	36	restriction	restriction	NN
cord-299731-sis9952k	412	1	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	412	2	Riboside	Riboside	NNP
cord-299731-sis9952k	412	3	Augments	augment	VBZ
cord-299731-sis9952k	412	4	the	the	DT
cord-299731-sis9952k	412	5	Aged	Aged	NNP
cord-299731-sis9952k	412	6	Human	Human	NNP
cord-299731-sis9952k	412	7	Skeletal	skeletal	JJ
cord-299731-sis9952k	412	8	Muscle	muscle	NN
cord-299731-sis9952k	412	9	NAD+	NAD+	NNP
cord-299731-sis9952k	412	10	Metabolome	Metabolome	NNP
cord-299731-sis9952k	412	11	and	and	CC
cord-299731-sis9952k	412	12	Induces	induce	VBZ
cord-299731-sis9952k	412	13	Transcriptomic	Transcriptomic	NNP
cord-299731-sis9952k	412	14	and	and	CC
cord-299731-sis9952k	412	15	Anti	anti	JJ
cord-299731-sis9952k	412	16	-	-	JJ
cord-299731-sis9952k	412	17	inflammatory	inflammatory	JJ
cord-299731-sis9952k	412	18	Signatures	signature	NNS
cord-299731-sis9952k	412	19	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	412	20	:	:	:
cord-299731-sis9952k	412	21	An	an	DT
cord-299731-sis9952k	412	22	Oral	oral	JJ
cord-299731-sis9952k	412	23	Antimicrobial	Antimicrobial	NNP
cord-299731-sis9952k	412	24	Agent	Agent	NNP
cord-299731-sis9952k	412	25	with	with	IN
cord-299731-sis9952k	412	26	Activity	Activity	NNP
cord-299731-sis9952k	412	27	against	against	IN
cord-299731-sis9952k	412	28	both	both	DT
cord-299731-sis9952k	412	29	Mycobacterium	Mycobacterium	NNP
cord-299731-sis9952k	412	30	tuberculosis	tuberculosis	NN
cord-299731-sis9952k	412	31	and	and	CC
cord-299731-sis9952k	412	32	Human	Human	NNP
cord-299731-sis9952k	412	33	Immunodeficiency	Immunodeficiency	NNP
cord-299731-sis9952k	412	34	Virus	Virus	NNP
cord-299731-sis9952k	412	35	Host	host	NN
cord-299731-sis9952k	412	36	NAD+	NAD+	NNP
cord-299731-sis9952k	412	37	metabolism	metabolism	NN
cord-299731-sis9952k	412	38	and	and	CC
cord-299731-sis9952k	412	39	infections	infection	NNS
cord-299731-sis9952k	412	40	:	:	:
cord-299731-sis9952k	413	1	Therapeutic	therapeutic	JJ
cord-299731-sis9952k	413	2	implications	implication	NNS
cord-299731-sis9952k	414	1	C	C	NNP
cord-299731-sis9952k	414	2	/	/	SYM
cord-299731-sis9952k	414	3	EBPε	EBPε	NNP
cord-299731-sis9952k	414	4	mediates	mediate	VBZ
cord-299731-sis9952k	414	5	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	414	6	-	-	HYPH
cord-299731-sis9952k	414	7	enhanced	enhance	VBN
cord-299731-sis9952k	414	8	clearance	clearance	NN
cord-299731-sis9952k	414	9	of	of	IN
cord-299731-sis9952k	414	10	Staphylococcus	Staphylococcus	NNP
cord-299731-sis9952k	414	11	aureus	aureus	NN
cord-299731-sis9952k	414	12	in	in	IN
cord-299731-sis9952k	414	13	mice	mice	NN
cord-299731-sis9952k	414	14	Niacin	niacin	NN
cord-299731-sis9952k	414	15	analogue	analogue	NN
cord-299731-sis9952k	414	16	,	,	,
cord-299731-sis9952k	414	17	6-Aminonicotinamide	6-aminonicotinamide	CD
cord-299731-sis9952k	414	18	,	,	,
cord-299731-sis9952k	414	19	a	a	DT
cord-299731-sis9952k	414	20	novel	novel	JJ
cord-299731-sis9952k	414	21	inhibitor	inhibitor	NN
cord-299731-sis9952k	414	22	of	of	IN
cord-299731-sis9952k	414	23	hepatitis	hepatitis	NNP
cord-299731-sis9952k	414	24	B	B	NNP
cord-299731-sis9952k	414	25	virus	virus	NN
cord-299731-sis9952k	414	26	replication	replication	NN
cord-299731-sis9952k	414	27	and	and	CC
cord-299731-sis9952k	414	28	HBsAg	hbsag	CD
cord-299731-sis9952k	414	29	production	production	NN
cord-299731-sis9952k	414	30	Reduction	Reduction	NNP
cord-299731-sis9952k	414	31	and	and	CC
cord-299731-sis9952k	414	32	Functional	functional	JJ
cord-299731-sis9952k	414	33	Exhaustion	exhaustion	NN
cord-299731-sis9952k	414	34	of	of	IN
cord-299731-sis9952k	414	35	T	T	NNP
cord-299731-sis9952k	414	36	Cells	cell	NNS
cord-299731-sis9952k	414	37	in	in	IN
cord-299731-sis9952k	414	38	Patients	patient	NNS
cord-299731-sis9952k	414	39	With	with	IN
cord-299731-sis9952k	414	40	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	414	41	Disease	Disease	NNP
cord-299731-sis9952k	414	42	2019	2019	CD
cord-299731-sis9952k	414	43	(	(	-LRB-
cord-299731-sis9952k	414	44	COVID-19	covid-19	NN
cord-299731-sis9952k	414	45	)	)	-RRB-
cord-299731-sis9952k	415	1	The	the	DT
cord-299731-sis9952k	415	2	Conserved	conserved	JJ
cord-299731-sis9952k	415	3	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	415	4	Macrodomain	Macrodomain	NNP
cord-299731-sis9952k	415	5	Promotes	promote	VBZ
cord-299731-sis9952k	415	6	Virulence	Virulence	NNP
cord-299731-sis9952k	415	7	and	and	CC
cord-299731-sis9952k	415	8	Suppresses	suppress	VBZ
cord-299731-sis9952k	415	9	the	the	DT
cord-299731-sis9952k	415	10	Innate	Innate	NNP
cord-299731-sis9952k	415	11	Immune	Immune	NNP
cord-299731-sis9952k	415	12	Response	response	NN
cord-299731-sis9952k	415	13	during	during	IN
cord-299731-sis9952k	415	14	Severe	severe	JJ
cord-299731-sis9952k	415	15	Acute	acute	JJ
cord-299731-sis9952k	415	16	Respiratory	respiratory	JJ
cord-299731-sis9952k	415	17	Syndrome	syndrome	NN
cord-299731-sis9952k	415	18	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	415	19	Infection	infection	NN
cord-299731-sis9952k	416	1	The	the	DT
cord-299731-sis9952k	416	2	impact	impact	NN
cord-299731-sis9952k	416	3	of	of	IN
cord-299731-sis9952k	416	4	PARPs	parp	NNS
cord-299731-sis9952k	416	5	and	and	CC
cord-299731-sis9952k	416	6	ADP	ADP	NNP
cord-299731-sis9952k	416	7	-	-	HYPH
cord-299731-sis9952k	416	8	ribosylation	ribosylation	NN
cord-299731-sis9952k	416	9	on	on	IN
cord-299731-sis9952k	416	10	inflammation	inflammation	NN
cord-299731-sis9952k	416	11	and	and	CC
cord-299731-sis9952k	416	12	host	host	NN
cord-299731-sis9952k	416	13	-	-	HYPH
cord-299731-sis9952k	416	14	pathogen	pathogen	NN
cord-299731-sis9952k	416	15	interactions	interaction	NNS
cord-299731-sis9952k	417	1	The	the	DT
cord-299731-sis9952k	417	2	coronavirus	coronavirus	NN
cord-299731-sis9952k	417	3	macrodomain	macrodomain	NN
cord-299731-sis9952k	417	4	is	be	VBZ
cord-299731-sis9952k	417	5	required	require	VBN
cord-299731-sis9952k	417	6	to	to	TO
cord-299731-sis9952k	417	7	prevent	prevent	VB
cord-299731-sis9952k	417	8	PARP	PARP	NNP
cord-299731-sis9952k	417	9	-	-	HYPH
cord-299731-sis9952k	417	10	mediated	mediate	VBN
cord-299731-sis9952k	417	11	inhibition	inhibition	NN
cord-299731-sis9952k	417	12	of	of	IN
cord-299731-sis9952k	417	13	virus	virus	NN
cord-299731-sis9952k	417	14	replication	replication	NN
cord-299731-sis9952k	417	15	and	and	CC
cord-299731-sis9952k	417	16	enhancement	enhancement	NN
cord-299731-sis9952k	417	17	of	of	IN
cord-299731-sis9952k	417	18	IFN	IFN	NNP
cord-299731-sis9952k	417	19	expression	expression	NN
cord-299731-sis9952k	418	1	The	the	DT
cord-299731-sis9952k	418	2	nsp3	nsp3	NNS
cord-299731-sis9952k	418	3	Macrodomain	Macrodomain	NNP
cord-299731-sis9952k	418	4	Promotes	promote	VBZ
cord-299731-sis9952k	418	5	Virulence	virulence	NN
cord-299731-sis9952k	418	6	in	in	IN
cord-299731-sis9952k	418	7	Mice	Mice	NNP
cord-299731-sis9952k	418	8	with	with	IN
cord-299731-sis9952k	418	9	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	418	10	-	-	HYPH
cord-299731-sis9952k	418	11	Induced	Induced	NNP
cord-299731-sis9952k	418	12	Encephalitis	Encephalitis	NNP
cord-299731-sis9952k	419	1	The	the	DT
cord-299731-sis9952k	419	2	interaction	interaction	NN
cord-299731-sis9952k	419	3	of	of	IN
cord-299731-sis9952k	419	4	the	the	DT
cord-299731-sis9952k	419	5	SARS	SARS	NNP
cord-299731-sis9952k	419	6	coronavirus	coronavirus	NN
cord-299731-sis9952k	419	7	non	non	JJ
cord-299731-sis9952k	419	8	-	-	JJ
cord-299731-sis9952k	419	9	structural	structural	JJ
cord-299731-sis9952k	419	10	protein	protein	NN
cord-299731-sis9952k	419	11	10	10	CD
cord-299731-sis9952k	419	12	with	with	IN
cord-299731-sis9952k	419	13	the	the	DT
cord-299731-sis9952k	419	14	cellular	cellular	JJ
cord-299731-sis9952k	419	15	oxido	oxido	NN
cord-299731-sis9952k	419	16	-	-	HYPH
cord-299731-sis9952k	419	17	reductase	reductase	NN
cord-299731-sis9952k	419	18	system	system	NN
cord-299731-sis9952k	419	19	causes	cause	VBZ
cord-299731-sis9952k	419	20	an	an	DT
cord-299731-sis9952k	419	21	extensive	extensive	JJ
cord-299731-sis9952k	419	22	cytopathic	cytopathic	JJ
cord-299731-sis9952k	419	23	effect	effect	NN
cord-299731-sis9952k	419	24	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	419	25	Infection	Infection	NNP
cord-299731-sis9952k	419	26	and	and	CC
cord-299731-sis9952k	419	27	PARP	PARP	NNP
cord-299731-sis9952k	419	28	Expression	Expression	NNP
cord-299731-sis9952k	419	29	Dysregulate	Dysregulate	NNP
cord-299731-sis9952k	419	30	the	the	DT
cord-299731-sis9952k	419	31	NAD	NAD	NNP
cord-299731-sis9952k	419	32	Metabolome	Metabolome	NNP
cord-299731-sis9952k	419	33	:	:	:
cord-299731-sis9952k	420	1	A	a	DT
cord-299731-sis9952k	420	2	Potentially	potentially	RB
cord-299731-sis9952k	420	3	Actionable	actionable	JJ
cord-299731-sis9952k	420	4	Component	component	NN
cord-299731-sis9952k	420	5	of	of	IN
cord-299731-sis9952k	420	6	Innate	Innate	NNP
cord-299731-sis9952k	420	7	Immunity	Immunity	NNP
cord-299731-sis9952k	420	8	Small	small	JJ
cord-299731-sis9952k	420	9	molecule	molecule	NN
cord-299731-sis9952k	420	10	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	420	11	N	n	NN
cord-299731-sis9952k	420	12	-	-	HYPH
cord-299731-sis9952k	420	13	methyltransferase	methyltransferase	NN
cord-299731-sis9952k	420	14	inhibitor	inhibitor	NN
cord-299731-sis9952k	420	15	activates	activate	VBZ
cord-299731-sis9952k	420	16	senescent	senescent	JJ
cord-299731-sis9952k	420	17	muscle	muscle	NN
cord-299731-sis9952k	420	18	stem	stem	NN
cord-299731-sis9952k	420	19	cells	cell	NNS
cord-299731-sis9952k	420	20	and	and	CC
cord-299731-sis9952k	420	21	improves	improve	VBZ
cord-299731-sis9952k	420	22	regenerative	regenerative	JJ
cord-299731-sis9952k	420	23	capacity	capacity	NN
cord-299731-sis9952k	420	24	of	of	IN
cord-299731-sis9952k	420	25	aged	aged	JJ
cord-299731-sis9952k	420	26	skeletal	skeletal	JJ
cord-299731-sis9952k	420	27	muscle	muscle	NN
cord-299731-sis9952k	420	28	The	the	DT
cord-299731-sis9952k	420	29	Conceptual	Conceptual	NNP
cord-299731-sis9952k	420	30	Framework	Framework	NNP
cord-299731-sis9952k	420	31	for	for	IN
cord-299731-sis9952k	420	32	SARS	SARS	NNP
cord-299731-sis9952k	420	33	-	-	HYPH
cord-299731-sis9952k	420	34	CoV-2	CoV-2	NNP
cord-299731-sis9952k	421	1	Related	related	JJ
cord-299731-sis9952k	421	2	Lymphopenia	Lymphopenia	NNP
cord-299731-sis9952k	421	3	Pathogenic	Pathogenic	NNP
cord-299731-sis9952k	421	4	T	T	NNP
cord-299731-sis9952k	421	5	cells	cell	NNS
cord-299731-sis9952k	421	6	and	and	CC
cord-299731-sis9952k	421	7	inflammatory	inflammatory	JJ
cord-299731-sis9952k	421	8	monocytes	monocyte	NNS
cord-299731-sis9952k	421	9	incite	incite	VBP
cord-299731-sis9952k	421	10	inflammatory	inflammatory	JJ
cord-299731-sis9952k	421	11	storm	storm	NN
cord-299731-sis9952k	421	12	in	in	IN
cord-299731-sis9952k	421	13	severe	severe	JJ
cord-299731-sis9952k	421	14	COVID-19	COVID-19	NNP
cord-299731-sis9952k	421	15	patients	patient	NNS
cord-299731-sis9952k	421	16	Mechanism	Mechanism	NNP
cord-299731-sis9952k	421	17	of	of	IN
cord-299731-sis9952k	421	18	cyclizing	cyclize	VBG
cord-299731-sis9952k	421	19	NAD	NAD	NNP
cord-299731-sis9952k	421	20	to	to	TO
cord-299731-sis9952k	421	21	cyclic	cyclic	JJ
cord-299731-sis9952k	421	22	ADP	ADP	NNP
cord-299731-sis9952k	421	23	-	-	HYPH
cord-299731-sis9952k	421	24	ribose	ribose	NN
cord-299731-sis9952k	421	25	by	by	IN
cord-299731-sis9952k	421	26	ADP	ADP	NNP
cord-299731-sis9952k	421	27	-	-	HYPH
cord-299731-sis9952k	421	28	ribosyl	ribosyl	JJ
cord-299731-sis9952k	421	29	cyclase	cyclase	NN
cord-299731-sis9952k	421	30	and	and	CC
cord-299731-sis9952k	421	31	CD38	CD38	NNP
cord-299731-sis9952k	421	32	Crosstalk	crosstalk	NN
cord-299731-sis9952k	421	33	between	between	IN
cord-299731-sis9952k	421	34	poly(ADP	poly(adp	NN
cord-299731-sis9952k	421	35	-	-	HYPH
cord-299731-sis9952k	421	36	ribose	ribose	NN
cord-299731-sis9952k	421	37	)	)	-RRB-
cord-299731-sis9952k	421	38	polymerase	polymerase	NN
cord-299731-sis9952k	421	39	and	and	CC
cord-299731-sis9952k	421	40	sirtuin	sirtuin	NNP
cord-299731-sis9952k	421	41	enzymes	enzyme	NNS
cord-299731-sis9952k	421	42	SIRT1	SIRT1	NNP
cord-299731-sis9952k	421	43	inhibits	inhibit	VBZ
cord-299731-sis9952k	421	44	transforming	transform	VBG
cord-299731-sis9952k	421	45	growth	growth	NN
cord-299731-sis9952k	421	46	factor	factor	NN
cord-299731-sis9952k	421	47	beta	beta	NN
cord-299731-sis9952k	421	48	-	-	HYPH
cord-299731-sis9952k	421	49	induced	induce	VBN
cord-299731-sis9952k	421	50	apoptosis	apoptosis	NN
cord-299731-sis9952k	421	51	in	in	IN
cord-299731-sis9952k	421	52	glomerular	glomerular	JJ
cord-299731-sis9952k	421	53	mesangial	mesangial	JJ
cord-299731-sis9952k	421	54	cells	cell	NNS
cord-299731-sis9952k	421	55	via	via	IN
cord-299731-sis9952k	422	1	Smad7	Smad7	NNP
cord-299731-sis9952k	422	2	deacetylation	deacetylation	NN
cord-299731-sis9952k	422	3	Cellular	Cellular	NNP
cord-299731-sis9952k	422	4	Immune	Immune	NNP
cord-299731-sis9952k	422	5	Responsesto	Responsesto	NNP
cord-299731-sis9952k	423	1	Severe	severe	JJ
cord-299731-sis9952k	423	2	Acute	acute	JJ
cord-299731-sis9952k	423	3	Respiratory	Respiratory	NNP
cord-299731-sis9952k	423	4	Syndrome	Syndrome	NNP
cord-299731-sis9952k	423	5	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	424	1	(	(	-LRB-
cord-299731-sis9952k	424	2	SARS	SARS	NNP
cord-299731-sis9952k	424	3	-	-	HYPH
cord-299731-sis9952k	424	4	CoV	CoV	NNP
cord-299731-sis9952k	424	5	)	)	-RRB-
cord-299731-sis9952k	424	6	Infection	infection	NN
cord-299731-sis9952k	424	7	in	in	IN
cord-299731-sis9952k	424	8	Senescent	Senescent	NNP
cord-299731-sis9952k	425	1	BALB	BALB	NNP
cord-299731-sis9952k	425	2	/	/	SYM
cord-299731-sis9952k	425	3	c	c	NN
cord-299731-sis9952k	425	4	Mice	mouse	NNS
cord-299731-sis9952k	425	5	:	:	:
cord-299731-sis9952k	425	6	CD4	CD4	NNP
cord-299731-sis9952k	425	7	+	+	CC
cord-299731-sis9952k	425	8	T	t	NN
cord-299731-sis9952k	425	9	cells	cell	NNS
cord-299731-sis9952k	425	10	are	be	VBP
cord-299731-sis9952k	425	11	important	important	JJ
cord-299731-sis9952k	425	12	in	in	IN
cord-299731-sis9952k	425	13	control	control	NN
cord-299731-sis9952k	425	14	of	of	IN
cord-299731-sis9952k	425	15	SARS	SARS	NNP
cord-299731-sis9952k	425	16	-	-	HYPH
cord-299731-sis9952k	425	17	CoV	CoV	NNP
cord-299731-sis9952k	425	18	infection	infection	NN
cord-299731-sis9952k	425	19	Exploring	explore	VBG
cord-299731-sis9952k	425	20	the	the	DT
cord-299731-sis9952k	425	21	pathogenesis	pathogenesis	NN
cord-299731-sis9952k	425	22	of	of	IN
cord-299731-sis9952k	425	23	severe	severe	JJ
cord-299731-sis9952k	425	24	acute	acute	JJ
cord-299731-sis9952k	425	25	respiratory	respiratory	JJ
cord-299731-sis9952k	425	26	syndrome	syndrome	NN
cord-299731-sis9952k	425	27	(	(	-LRB-
cord-299731-sis9952k	425	28	SARS	SARS	NNP
cord-299731-sis9952k	425	29	)	)	-RRB-
cord-299731-sis9952k	425	30	:	:	:
cord-299731-sis9952k	426	1	The	the	DT
cord-299731-sis9952k	426	2	tissue	tissue	NN
cord-299731-sis9952k	426	3	distribution	distribution	NN
cord-299731-sis9952k	426	4	of	of	IN
cord-299731-sis9952k	426	5	the	the	DT
cord-299731-sis9952k	426	6	coronavirus	coronavirus	NN
cord-299731-sis9952k	426	7	(	(	-LRB-
cord-299731-sis9952k	426	8	SARS	SARS	NNP
cord-299731-sis9952k	426	9	-	-	HYPH
cord-299731-sis9952k	426	10	CoV	CoV	NNP
cord-299731-sis9952k	426	11	)	)	-RRB-
cord-299731-sis9952k	426	12	and	and	CC
cord-299731-sis9952k	426	13	its	-PRON-	PRP$
cord-299731-sis9952k	426	14	putative	putative	JJ
cord-299731-sis9952k	426	15	receptor	receptor	NN
cord-299731-sis9952k	426	16	,	,	,
cord-299731-sis9952k	426	17	angiotensin	angiotensin	NN
cord-299731-sis9952k	426	18	-	-	HYPH
cord-299731-sis9952k	426	19	converting	convert	VBG
cord-299731-sis9952k	426	20	enzyme	enzyme	NN
cord-299731-sis9952k	426	21	2	2	CD
cord-299731-sis9952k	427	1	(	(	-LRB-
cord-299731-sis9952k	427	2	ACE2	ACE2	NNP
cord-299731-sis9952k	427	3	)	)	-RRB-
cord-299731-sis9952k	427	4	Dysregulation	Dysregulation	NNP
cord-299731-sis9952k	427	5	of	of	IN
cord-299731-sis9952k	427	6	Immune	Immune	NNP
cord-299731-sis9952k	427	7	Response	response	NN
cord-299731-sis9952k	427	8	in	in	IN
cord-299731-sis9952k	427	9	Patients	patient	NNS
cord-299731-sis9952k	427	10	With	with	IN
cord-299731-sis9952k	427	11	Coronavirus	Coronavirus	NNP
cord-299731-sis9952k	427	12	NAD	NAD	NNP
cord-299731-sis9952k	427	13	and	and	CC
cord-299731-sis9952k	427	14	the	the	DT
cord-299731-sis9952k	427	15	aging	aging	NN
cord-299731-sis9952k	427	16	process	process	NN
cord-299731-sis9952k	427	17	:	:	:
cord-299731-sis9952k	427	18	Role	role	NN
cord-299731-sis9952k	427	19	in	in	IN
cord-299731-sis9952k	427	20	life	life	NN
cord-299731-sis9952k	427	21	,	,	,
cord-299731-sis9952k	427	22	death	death	NN
cord-299731-sis9952k	427	23	and	and	CC
cord-299731-sis9952k	427	24	everything	everything	NN
cord-299731-sis9952k	427	25	in	in	IN
cord-299731-sis9952k	427	26	between	between	IN
cord-299731-sis9952k	427	27	NAD+	NAD+	NNP
cord-299731-sis9952k	427	28	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	427	29	,	,	,
cord-299731-sis9952k	427	30	aging	age	VBG
cord-299731-sis9952k	427	31	,	,	,
cord-299731-sis9952k	427	32	and	and	CC
cord-299731-sis9952k	427	33	disease	disease	NN
cord-299731-sis9952k	427	34	Niacin	Niacin	NNP
cord-299731-sis9952k	428	1	Modulates	modulate	VBZ
cord-299731-sis9952k	428	2	Pro	pro	JJ
cord-299731-sis9952k	428	3	-	-	JJ
cord-299731-sis9952k	428	4	inflammatory	inflammatory	JJ
cord-299731-sis9952k	428	5	Cytokine	cytokine	NN
cord-299731-sis9952k	428	6	Secretion	secretion	NN
cord-299731-sis9952k	428	7	.	.	.
cord-299731-sis9952k	429	1	A	a	DT
cord-299731-sis9952k	429	2	Potential	Potential	NNP
cord-299731-sis9952k	429	3	Mechanism	Mechanism	NNP
cord-299731-sis9952k	429	4	Involved	involve	VBN
cord-299731-sis9952k	429	5	in	in	IN
cord-299731-sis9952k	429	6	its	-PRON-	PRP$
cord-299731-sis9952k	429	7	Anti	anti	JJ
cord-299731-sis9952k	429	8	-	-	JJ
cord-299731-sis9952k	429	9	atherosclerotic	atherosclerotic	JJ
cord-299731-sis9952k	429	10	Effect	effect	NN
cord-299731-sis9952k	430	1	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	430	2	Exacerbates	exacerbate	VBZ
cord-299731-sis9952k	430	3	Hypoxemia	Hypoxemia	NNP
cord-299731-sis9952k	430	4	in	in	IN
cord-299731-sis9952k	430	5	Ventilator	Ventilator	NNP
cord-299731-sis9952k	430	6	-	-	HYPH
cord-299731-sis9952k	430	7	Induced	Induced	NNP
cord-299731-sis9952k	430	8	Lung	Lung	NNP
cord-299731-sis9952k	430	9	Injury	Injury	NNP
cord-299731-sis9952k	430	10	Independent	Independent	NNP
cord-299731-sis9952k	430	11	of	of	IN
cord-299731-sis9952k	430	12	Neutrophil	Neutrophil	NNP
cord-299731-sis9952k	430	13	Infiltration	Infiltration	NNP
cord-299731-sis9952k	430	14	Role	Role	NNP
cord-299731-sis9952k	430	15	of	of	IN
cord-299731-sis9952k	430	16	poly	poly	NNP
cord-299731-sis9952k	430	17	(	(	-LRB-
cord-299731-sis9952k	430	18	ADP	ADP	NNP
cord-299731-sis9952k	430	19	)	)	-RRB-
cord-299731-sis9952k	430	20	ribose	ribose	NN
cord-299731-sis9952k	430	21	polymerase-1	polymerase-1	NNP
cord-299731-sis9952k	430	22	inhibition	inhibition	NN
cord-299731-sis9952k	430	23	by	by	IN
cord-299731-sis9952k	430	24	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	430	25	as	as	IN
cord-299731-sis9952k	430	26	a	a	DT
cord-299731-sis9952k	430	27	possible	possible	JJ
cord-299731-sis9952k	430	28	additive	additive	NN
cord-299731-sis9952k	430	29	treatment	treatment	NN
cord-299731-sis9952k	430	30	to	to	TO
cord-299731-sis9952k	430	31	modulate	modulate	VB
cord-299731-sis9952k	430	32	host	host	NN
cord-299731-sis9952k	430	33	immune	immune	JJ
cord-299731-sis9952k	430	34	response	response	NN
cord-299731-sis9952k	430	35	and	and	CC
cord-299731-sis9952k	430	36	prevention	prevention	NN
cord-299731-sis9952k	430	37	of	of	IN
cord-299731-sis9952k	430	38	cytokine	cytokine	NN
cord-299731-sis9952k	430	39	storm	storm	NN
cord-299731-sis9952k	430	40	in	in	IN
cord-299731-sis9952k	430	41	COVID-19	COVID-19	NNP
cord-299731-sis9952k	430	42	COVID-19	COVID-19	NNP
cord-299731-sis9952k	430	43	infection	infection	NN
cord-299731-sis9952k	431	1	:	:	:
cord-299731-sis9952k	431	2	The	the	DT
cord-299731-sis9952k	431	3	perspectives	perspective	NNS
cord-299731-sis9952k	431	4	on	on	IN
cord-299731-sis9952k	431	5	immune	immune	JJ
cord-299731-sis9952k	431	6	responses	response	NNS
cord-299731-sis9952k	431	7	Effects	effect	NNS
cord-299731-sis9952k	431	8	of	of	IN
cord-299731-sis9952k	431	9	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	431	10	and	and	CC
cord-299731-sis9952k	431	11	Niacin	Niacin	NNP
cord-299731-sis9952k	431	12	on	on	IN
cord-299731-sis9952k	431	13	Bleomycin	Bleomycin	NNP
cord-299731-sis9952k	431	14	-	-	HYPH
cord-299731-sis9952k	431	15	Induced	Induced	NNP
cord-299731-sis9952k	431	16	Acute	Acute	NNP
cord-299731-sis9952k	431	17	Injury	Injury	NNP
cord-299731-sis9952k	431	18	and	and	CC
cord-299731-sis9952k	431	19	Subsequent	Subsequent	NNP
cord-299731-sis9952k	431	20	Fibrosis	Fibrosis	NNP
cord-299731-sis9952k	431	21	in	in	IN
cord-299731-sis9952k	431	22	Hamster	Hamster	NNP
cord-299731-sis9952k	431	23	Lungs	Lungs	NNPS
cord-299731-sis9952k	431	24	Niacin	Niacin	NNP
cord-299731-sis9952k	431	25	attenuates	attenuate	VBZ
cord-299731-sis9952k	431	26	acute	acute	JJ
cord-299731-sis9952k	431	27	lung	lung	NN
cord-299731-sis9952k	431	28	injury	injury	NN
cord-299731-sis9952k	431	29	induced	induce	VBN
cord-299731-sis9952k	431	30	by	by	IN
cord-299731-sis9952k	431	31	lipopolysaccharide	lipopolysaccharide	NN
cord-299731-sis9952k	431	32	in	in	IN
cord-299731-sis9952k	431	33	the	the	DT
cord-299731-sis9952k	431	34	hamster	hamster	NN
cord-299731-sis9952k	431	35	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	431	36	riboside	riboside	NN
cord-299731-sis9952k	431	37	is	be	VBZ
cord-299731-sis9952k	431	38	uniquely	uniquely	RB
cord-299731-sis9952k	431	39	and	and	CC
cord-299731-sis9952k	431	40	orally	orally	RB
cord-299731-sis9952k	431	41	bioavailable	bioavailable	JJ
cord-299731-sis9952k	431	42	in	in	IN
cord-299731-sis9952k	431	43	mice	mouse	NNS
cord-299731-sis9952k	431	44	and	and	CC
cord-299731-sis9952k	431	45	humans	human	NNS
cord-299731-sis9952k	432	1	An	an	DT
cord-299731-sis9952k	432	2	open	open	JJ
cord-299731-sis9952k	432	3	-	-	HYPH
cord-299731-sis9952k	432	4	label	label	NN
cord-299731-sis9952k	432	5	,	,	,
cord-299731-sis9952k	432	6	non	non	JJ
cord-299731-sis9952k	432	7	-	-	JJ
cord-299731-sis9952k	432	8	randomized	randomized	JJ
cord-299731-sis9952k	432	9	study	study	NN
cord-299731-sis9952k	432	10	of	of	IN
cord-299731-sis9952k	432	11	the	the	DT
cord-299731-sis9952k	432	12	pharmacokinetics	pharmacokinetic	NNS
cord-299731-sis9952k	432	13	of	of	IN
cord-299731-sis9952k	432	14	the	the	DT
cord-299731-sis9952k	432	15	nutritional	nutritional	JJ
cord-299731-sis9952k	432	16	supplement	supplement	NN
cord-299731-sis9952k	432	17	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	432	18	riboside	riboside	NN
cord-299731-sis9952k	432	19	(	(	-LRB-
cord-299731-sis9952k	432	20	NR	NR	NNP
cord-299731-sis9952k	432	21	)	)	-RRB-
cord-299731-sis9952k	432	22	and	and	CC
cord-299731-sis9952k	432	23	its	-PRON-	PRP$
cord-299731-sis9952k	432	24	effects	effect	NNS
cord-299731-sis9952k	432	25	on	on	IN
cord-299731-sis9952k	432	26	blood	blood	NN
cord-299731-sis9952k	432	27	NAD+	NAD+	NNP
cord-299731-sis9952k	432	28	levels	level	NNS
cord-299731-sis9952k	432	29	in	in	IN
cord-299731-sis9952k	432	30	healthy	healthy	JJ
cord-299731-sis9952k	432	31	volunteers	volunteer	NNS
cord-299731-sis9952k	432	32	Safety	Safety	NNP
cord-299731-sis9952k	432	33	Considerations	consideration	NNS
cord-299731-sis9952k	432	34	with	with	IN
cord-299731-sis9952k	432	35	Niacin	Niacin	NNP
cord-299731-sis9952k	432	36	Therapy	Therapy	NNP
cord-299731-sis9952k	432	37	ACC	ACC	NNP
cord-299731-sis9952k	432	38	/	/	SYM
cord-299731-sis9952k	432	39	AHA	AHA	NNP
cord-299731-sis9952k	432	40	Guideline	Guideline	NNP
cord-299731-sis9952k	432	41	on	on	IN
cord-299731-sis9952k	432	42	the	the	DT
cord-299731-sis9952k	432	43	Treatment	treatment	NN
cord-299731-sis9952k	432	44	of	of	IN
cord-299731-sis9952k	432	45	Blood	blood	NN
cord-299731-sis9952k	432	46	Cholesterol	cholesterol	NN
cord-299731-sis9952k	432	47	to	to	TO
cord-299731-sis9952k	432	48	Reduce	reduce	VB
cord-299731-sis9952k	432	49	Atherosclerotic	atherosclerotic	JJ
cord-299731-sis9952k	432	50	Cardiovascular	cardiovascular	JJ
cord-299731-sis9952k	432	51	Risk	risk	NN
cord-299731-sis9952k	432	52	in	in	IN
cord-299731-sis9952k	432	53	Adults	Adults	NNP
cord-299731-sis9952k	432	54	NRK1	NRK1	NNP
cord-299731-sis9952k	432	55	controls	control	VBZ
cord-299731-sis9952k	432	56	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	432	57	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	432	58	and	and	CC
cord-299731-sis9952k	432	59	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	432	60	riboside	riboside	NN
cord-299731-sis9952k	432	61	metabolism	metabolism	NN
cord-299731-sis9952k	432	62	in	in	IN
cord-299731-sis9952k	432	63	mammalian	mammalian	JJ
cord-299731-sis9952k	432	64	cells	cell	NNS
cord-299731-sis9952k	432	65	Quantitative	Quantitative	NNP
cord-299731-sis9952k	432	66	Analysis	Analysis	NNP
cord-299731-sis9952k	432	67	of	of	IN
cord-299731-sis9952k	432	68	NAD	NAD	NNP
cord-299731-sis9952k	432	69	Synthesis	Synthesis	NNP
cord-299731-sis9952k	432	70	-	-	HYPH
cord-299731-sis9952k	432	71	Breakdown	Breakdown	NNP
cord-299731-sis9952k	432	72	Fluxes	Fluxes	NNP
cord-299731-sis9952k	432	73	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	432	74	Riboside	Riboside	NNP
cord-299731-sis9952k	432	75	,	,	,
cord-299731-sis9952k	432	76	an	an	DT
cord-299731-sis9952k	432	77	Unusual	unusual	JJ
cord-299731-sis9952k	432	78	,	,	,
cord-299731-sis9952k	432	79	Non	Non	NNP
cord-299731-sis9952k	432	80	-	-	JJ
cord-299731-sis9952k	432	81	Typical	typical	JJ
cord-299731-sis9952k	432	82	,	,	,
cord-299731-sis9952k	432	83	Substrate	Substrate	NNP
cord-299731-sis9952k	432	84	of	of	IN
cord-299731-sis9952k	432	85	Purified	Purified	NNP
cord-299731-sis9952k	432	86	Purine	Purine	NNP
cord-299731-sis9952k	432	87	-	-	HYPH
cord-299731-sis9952k	432	88	Nucleoside	Nucleoside	NNP
cord-299731-sis9952k	432	89	Phosphorylases	Phosphorylases	NNP
cord-299731-sis9952k	432	90	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	432	91	Mononucleotide	Mononucleotide	NNP
cord-299731-sis9952k	432	92	:	:	:
cord-299731-sis9952k	432	93	Exploration	exploration	NN
cord-299731-sis9952k	432	94	of	of	IN
cord-299731-sis9952k	432	95	Diverse	Diverse	NNP
cord-299731-sis9952k	432	96	Therapeutic	Therapeutic	NNP
cord-299731-sis9952k	432	97	Applications	Applications	NNPS
cord-299731-sis9952k	432	98	of	of	IN
cord-299731-sis9952k	432	99	a	a	DT
cord-299731-sis9952k	432	100	Potential	Potential	NNP
cord-299731-sis9952k	432	101	Molecule	Molecule	NNP
cord-299731-sis9952k	432	102	Niacin	niacin	NN
cord-299731-sis9952k	432	103	-	-	HYPH
cord-299731-sis9952k	432	104	tryptophan	tryptophan	NN
cord-299731-sis9952k	432	105	relationships	relationship	NNS
cord-299731-sis9952k	432	106	in	in	IN
cord-299731-sis9952k	432	107	the	the	DT
cord-299731-sis9952k	432	108	development	development	NN
cord-299731-sis9952k	432	109	of	of	IN
cord-299731-sis9952k	432	110	pellagra	pellagra	NN
cord-299731-sis9952k	433	1	The	the	DT
cord-299731-sis9952k	433	2	NAD	NAD	NNP
cord-299731-sis9952k	433	3	-	-	HYPH
cord-299731-sis9952k	433	4	Booster	Booster	NNP
cord-299731-sis9952k	433	5	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	433	6	Riboside	Riboside	NNP
cord-299731-sis9952k	433	7	Potently	Potently	NNP
cord-299731-sis9952k	433	8	Stimulates	stimulate	VBZ
cord-299731-sis9952k	433	9	Hematopoiesis	Hematopoiesis	NNP
cord-299731-sis9952k	433	10	through	through	IN
cord-299731-sis9952k	433	11	Increased	Increased	NNP
cord-299731-sis9952k	433	12	Mitochondrial	Mitochondrial	NNP
cord-299731-sis9952k	433	13	Clearance	Clearance	NNP
cord-299731-sis9952k	433	14	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	433	15	riboside	riboside	NN
cord-299731-sis9952k	433	16	,	,	,
cord-299731-sis9952k	433	17	a	a	DT
cord-299731-sis9952k	433	18	form	form	NN
cord-299731-sis9952k	433	19	of	of	IN
cord-299731-sis9952k	433	20	vitamin	vitamin	NN
cord-299731-sis9952k	433	21	B3	b3	NN
cord-299731-sis9952k	433	22	and	and	CC
cord-299731-sis9952k	433	23	NAD+	NAD+	NNP
cord-299731-sis9952k	433	24	precursor	precursor	NN
cord-299731-sis9952k	433	25	,	,	,
cord-299731-sis9952k	433	26	relieves	relieve	VBZ
cord-299731-sis9952k	433	27	the	the	DT
cord-299731-sis9952k	433	28	nociceptive	nociceptive	JJ
cord-299731-sis9952k	433	29	and	and	CC
cord-299731-sis9952k	433	30	aversive	aversive	JJ
cord-299731-sis9952k	433	31	dimensions	dimension	NNS
cord-299731-sis9952k	433	32	of	of	IN
cord-299731-sis9952k	433	33	paclitaxel	paclitaxel	NN
cord-299731-sis9952k	433	34	-	-	HYPH
cord-299731-sis9952k	433	35	induced	induce	VBN
cord-299731-sis9952k	433	36	peripheral	peripheral	JJ
cord-299731-sis9952k	433	37	neuropathy	neuropathy	NN
cord-299731-sis9952k	433	38	in	in	IN
cord-299731-sis9952k	433	39	female	female	JJ
cord-299731-sis9952k	433	40	rats	rat	NNS
cord-299731-sis9952k	434	1	Nicotinamide	nicotinamide	NN
cord-299731-sis9952k	434	2	riboside	riboside	NN
cord-299731-sis9952k	434	3	kinases	kinase	NNS
cord-299731-sis9952k	434	4	display	display	VBP
cord-299731-sis9952k	434	5	redundancy	redundancy	NN
cord-299731-sis9952k	434	6	in	in	IN
cord-299731-sis9952k	434	7	mediating	mediate	VBG
cord-299731-sis9952k	434	8	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	434	9	mononucleotide	mononucleotide	NN
cord-299731-sis9952k	434	10	and	and	CC
cord-299731-sis9952k	434	11	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	434	12	riboside	riboside	NN
cord-299731-sis9952k	434	13	metabolism	metabolism	NN
cord-299731-sis9952k	434	14	in	in	IN
cord-299731-sis9952k	434	15	skeletal	skeletal	JJ
cord-299731-sis9952k	434	16	muscle	muscle	NN
cord-299731-sis9952k	434	17	cells	cell	NNS
cord-299731-sis9952k	435	1	Slc12a8	Slc12a8	NNP
cord-299731-sis9952k	435	2	is	be	VBZ
cord-299731-sis9952k	436	1	a	a	DT
cord-299731-sis9952k	436	2	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	436	3	mononucleotide	mononucleotide	NN
cord-299731-sis9952k	436	4	transporter	transporter	NN
cord-299731-sis9952k	436	5	A	a	DT
cord-299731-sis9952k	436	6	reduced	reduce	VBN
cord-299731-sis9952k	436	7	form	form	NN
cord-299731-sis9952k	436	8	of	of	IN
cord-299731-sis9952k	436	9	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	436	10	riboside	riboside	NN
cord-299731-sis9952k	436	11	defines	define	VBZ
cord-299731-sis9952k	436	12	a	a	DT
cord-299731-sis9952k	436	13	new	new	JJ
cord-299731-sis9952k	436	14	path	path	NN
cord-299731-sis9952k	436	15	for	for	IN
cord-299731-sis9952k	436	16	NAD+	NAD+	NNP
cord-299731-sis9952k	436	17	biosynthesis	biosynthesis	NN
cord-299731-sis9952k	436	18	and	and	CC
cord-299731-sis9952k	436	19	acts	act	VBZ
cord-299731-sis9952k	436	20	as	as	IN
cord-299731-sis9952k	436	21	an	an	DT
cord-299731-sis9952k	436	22	orally	orally	RB
cord-299731-sis9952k	436	23	bioavailable	bioavailable	JJ
cord-299731-sis9952k	436	24	NAD+	NAD+	NNP
cord-299731-sis9952k	436	25	precursor	precursor	NN
cord-299731-sis9952k	437	1	Dihydronicotinamide	dihydronicotinamide	JJ
cord-299731-sis9952k	437	2	riboside	riboside	NN
cord-299731-sis9952k	437	3	is	be	VBZ
cord-299731-sis9952k	437	4	a	a	DT
cord-299731-sis9952k	437	5	potent	potent	JJ
cord-299731-sis9952k	437	6	NAD+	NAD+	NNP
cord-299731-sis9952k	437	7	concentration	concentration	NN
cord-299731-sis9952k	437	8	enhancer	enhancer	NN
cord-299731-sis9952k	438	1	in	in	IN
cord-299731-sis9952k	438	2	vitro	vitro	FW
cord-299731-sis9952k	438	3	and	and	CC
cord-299731-sis9952k	438	4	in	in	IN
cord-299731-sis9952k	438	5	vivo	vivo	FW
cord-299731-sis9952k	438	6	NRH	nrh	NN
cord-299731-sis9952k	438	7	salvage	salvage	NN
cord-299731-sis9952k	438	8	and	and	CC
cord-299731-sis9952k	438	9	conversion	conversion	NN
cord-299731-sis9952k	438	10	to	to	IN
cord-299731-sis9952k	438	11	NAD+	NAD+	NNP
cord-299731-sis9952k	438	12	requires	require	VBZ
cord-299731-sis9952k	438	13	NRH	nrh	NN
cord-299731-sis9952k	438	14	kinase	kinase	NN
cord-299731-sis9952k	438	15	activity	activity	NN
cord-299731-sis9952k	438	16	by	by	IN
cord-299731-sis9952k	438	17	adenosine	adenosine	NN
cord-299731-sis9952k	438	18	kinase	kinase	NN
cord-299731-sis9952k	438	19	Niacin	Niacin	NNP
cord-299731-sis9952k	438	20	:	:	:
cord-299731-sis9952k	439	1	Chemical	chemical	NN
cord-299731-sis9952k	439	2	forms	form	NNS
cord-299731-sis9952k	439	3	,	,	,
cord-299731-sis9952k	439	4	bioavailability	bioavailability	NN
cord-299731-sis9952k	439	5	,	,	,
cord-299731-sis9952k	439	6	and	and	CC
cord-299731-sis9952k	439	7	health	health	NN
cord-299731-sis9952k	439	8	effects	effect	NNS
cord-299731-sis9952k	440	1	A	a	DT
cord-299731-sis9952k	440	2	rise	rise	NN
cord-299731-sis9952k	440	3	in	in	IN
cord-299731-sis9952k	440	4	NAD	NAD	NNP
cord-299731-sis9952k	440	5	precursor	precursor	NN
cord-299731-sis9952k	440	6	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	440	7	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	440	8	(	(	-LRB-
cord-299731-sis9952k	440	9	NMN	NMN	NNP
cord-299731-sis9952k	440	10	)	)	-RRB-
cord-299731-sis9952k	440	11	after	after	IN
cord-299731-sis9952k	440	12	injury	injury	NN
cord-299731-sis9952k	440	13	promotes	promote	VBZ
cord-299731-sis9952k	440	14	axon	axon	NN
cord-299731-sis9952k	440	15	degeneration	degeneration	NN
cord-299731-sis9952k	440	16	Effect	Effect	NNP
cord-299731-sis9952k	440	17	of	of	IN
cord-299731-sis9952k	440	18	oral	oral	JJ
cord-299731-sis9952k	440	19	administration	administration	NN
cord-299731-sis9952k	440	20	of	of	IN
cord-299731-sis9952k	440	21	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	440	22	mononucleotide	mononucleotide	NNP
cord-299731-sis9952k	440	23	on	on	IN
cord-299731-sis9952k	440	24	clinical	clinical	JJ
cord-299731-sis9952k	440	25	parameters	parameter	NNS
cord-299731-sis9952k	440	26	and	and	CC
cord-299731-sis9952k	440	27	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	440	28	metabolite	metabolite	NN
cord-299731-sis9952k	440	29	levels	level	NNS
cord-299731-sis9952k	440	30	in	in	IN
cord-299731-sis9952k	440	31	healthy	healthy	JJ
cord-299731-sis9952k	440	32	Japanese	japanese	JJ
cord-299731-sis9952k	440	33	men	man	NNS
cord-299731-sis9952k	440	34	PUMA	PUMA	NNP
cord-299731-sis9952k	440	35	-	-	HYPH
cord-299731-sis9952k	440	36	G	g	NN
cord-299731-sis9952k	440	37	/	/	SYM
cord-299731-sis9952k	440	38	HM74A	hm74a	NN
cord-299731-sis9952k	440	39	)	)	-RRB-
cord-299731-sis9952k	440	40	mediates	mediate	VBZ
cord-299731-sis9952k	440	41	nicotinic	nicotinic	JJ
cord-299731-sis9952k	440	42	acid	acid	NN
cord-299731-sis9952k	440	43	-	-	HYPH
cord-299731-sis9952k	440	44	induced	induce	VBN
cord-299731-sis9952k	440	45	flushing	flush	VBG
cord-299731-sis9952k	440	46	NAD+	NAD+	NNP
cord-299731-sis9952k	440	47	metabolism	metabolism	NN
cord-299731-sis9952k	440	48	in	in	IN
cord-299731-sis9952k	440	49	health	health	NN
cord-299731-sis9952k	440	50	and	and	CC
cord-299731-sis9952k	440	51	disease	disease	NN
cord-299731-sis9952k	440	52	Generation	Generation	NNP
cord-299731-sis9952k	440	53	,	,	,
cord-299731-sis9952k	440	54	Release	Release	NNP
cord-299731-sis9952k	440	55	,	,	,
cord-299731-sis9952k	440	56	and	and	CC
cord-299731-sis9952k	440	57	Uptake	Uptake	NNP
cord-299731-sis9952k	440	58	of	of	IN
cord-299731-sis9952k	440	59	the	the	DT
cord-299731-sis9952k	440	60	NAD	NAD	NNP
cord-299731-sis9952k	440	61	Precursor	Precursor	NNP
cord-299731-sis9952k	440	62	Nicotinic	Nicotinic	NNP
cord-299731-sis9952k	440	63	Acid	acid	NN
cord-299731-sis9952k	440	64	Riboside	Riboside	NNP
cord-299731-sis9952k	440	65	by	by	IN
cord-299731-sis9952k	440	66	Human	Human	NNP
cord-299731-sis9952k	440	67	Cells	cell	NNS
cord-299731-sis9952k	441	1	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	441	2	Riboside	Riboside	NNP
cord-299731-sis9952k	441	3	Kinase	Kinase	NNP
cord-299731-sis9952k	441	4	Structures	structure	NNS
cord-299731-sis9952k	441	5	Reveal	reveal	VBP
cord-299731-sis9952k	441	6	New	new	JJ
cord-299731-sis9952k	441	7	Pathways	pathway	NNS
cord-299731-sis9952k	441	8	to	to	IN
cord-299731-sis9952k	441	9	NAD+	NAD+	NNP
cord-299731-sis9952k	441	10	Syntheses	Syntheses	NNPS
cord-299731-sis9952k	441	11	and	and	CC
cord-299731-sis9952k	441	12	chemical	chemical	JJ
cord-299731-sis9952k	441	13	properties	property	NNS
cord-299731-sis9952k	441	14	of	of	IN
cord-299731-sis9952k	441	15	β	β	NN
cord-299731-sis9952k	441	16	-	-	HYPH
cord-299731-sis9952k	441	17	nicotinamide	nicotinamide	JJ
cord-299731-sis9952k	441	18	riboside	riboside	NN
cord-299731-sis9952k	441	19	and	and	CC
cord-299731-sis9952k	441	20	its	-PRON-	PRP$
cord-299731-sis9952k	441	21	analogues	analogue	NNS
cord-299731-sis9952k	441	22	and	and	CC
cord-299731-sis9952k	441	23	derivatives	derivative	NNS
cord-299731-sis9952k	441	24	Simple	simple	JJ
cord-299731-sis9952k	441	25	methods	method	NNS
cord-299731-sis9952k	441	26	of	of	IN
cord-299731-sis9952k	441	27	preparing	prepare	VBG
cord-299731-sis9952k	441	28	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	441	29	mononucleotide	mononucleotide	NN
cord-299731-sis9952k	441	30	Simple	simple	JJ
cord-299731-sis9952k	441	31	methods	method	NNS
cord-299731-sis9952k	441	32	for	for	IN
cord-299731-sis9952k	441	33	preparing	prepare	VBG
cord-299731-sis9952k	441	34	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	441	35	mononucleotide	mononucleotide	NN
cord-299731-sis9952k	441	36	and	and	CC
cord-299731-sis9952k	441	37	related	relate	VBN
cord-299731-sis9952k	441	38	analogs	analog	NNS
cord-299731-sis9952k	442	1	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	442	2	Riboside	Riboside	NNP
cord-299731-sis9952k	442	3	Derivatives	derivative	NNS
cord-299731-sis9952k	442	4	:	:	:
cord-299731-sis9952k	442	5	Single	Single	NNP
cord-299731-sis9952k	442	6	Crystal	Crystal	NNP
cord-299731-sis9952k	442	7	Growth	Growth	NNP
cord-299731-sis9952k	442	8	and	and	CC
cord-299731-sis9952k	442	9	Determination	Determination	NNP
cord-299731-sis9952k	442	10	of	of	IN
cord-299731-sis9952k	442	11	X	x	NN
cord-299731-sis9952k	442	12	-	-	NN
cord-299731-sis9952k	442	13	ray	ray	NN
cord-299731-sis9952k	442	14	Structures	structure	NNS
cord-299731-sis9952k	442	15	Crystalline	Crystalline	NNP
cord-299731-sis9952k	442	16	Form	Form	NNP
cord-299731-sis9952k	442	17	of	of	IN
cord-299731-sis9952k	442	18	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	442	19	Riboside	Riboside	NNP
cord-299731-sis9952k	442	20	Syntheses	synthesis	NNS
cord-299731-sis9952k	442	21	of	of	IN
cord-299731-sis9952k	442	22	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	442	23	riboside	riboside	NN
cord-299731-sis9952k	442	24	and	and	CC
cord-299731-sis9952k	442	25	derivatives	derivative	NNS
cord-299731-sis9952k	442	26	:	:	:
cord-299731-sis9952k	442	27	Effective	effective	JJ
cord-299731-sis9952k	442	28	agents	agent	NNS
cord-299731-sis9952k	442	29	for	for	IN
cord-299731-sis9952k	442	30	increasing	increase	VBG
cord-299731-sis9952k	442	31	nicotinamide	nicotinamide	NN
cord-299731-sis9952k	442	32	adenine	adenine	NN
cord-299731-sis9952k	442	33	dinucleotide	dinucleotide	NN
cord-299731-sis9952k	442	34	concentrations	concentration	NNS
cord-299731-sis9952k	442	35	in	in	IN
cord-299731-sis9952k	442	36	mammalian	mammalian	JJ
cord-299731-sis9952k	442	37	cells	cell	NNS
cord-299731-sis9952k	442	38	Safety	safety	NN
cord-299731-sis9952k	442	39	and	and	CC
cord-299731-sis9952k	442	40	Metabolism	metabolism	NN
cord-299731-sis9952k	442	41	of	of	IN
cord-299731-sis9952k	442	42	Long	long	JJ
cord-299731-sis9952k	442	43	-	-	HYPH
cord-299731-sis9952k	442	44	term	term	NN
cord-299731-sis9952k	442	45	Administration	Administration	NNP
cord-299731-sis9952k	442	46	of	of	IN
cord-299731-sis9952k	442	47	NIAGEN	NIAGEN	NNP
cord-299731-sis9952k	442	48	(	(	-LRB-
cord-299731-sis9952k	442	49	Nicotinamide	Nicotinamide	NNP
cord-299731-sis9952k	442	50	Riboside	Riboside	NNP
cord-299731-sis9952k	442	51	Chloride	Chloride	NNP
cord-299731-sis9952k	442	52	)	)	-RRB-
cord-299731-sis9952k	442	53	in	in	IN
cord-299731-sis9952k	442	54	a	a	DT
cord-299731-sis9952k	442	55	Randomized	randomized	JJ
cord-299731-sis9952k	442	56	,	,	,
cord-299731-sis9952k	442	57	Double	double	JJ
cord-299731-sis9952k	442	58	-	-	HYPH
cord-299731-sis9952k	442	59	Blind	blind	JJ
cord-299731-sis9952k	442	60	,	,	,
cord-299731-sis9952k	442	61	Placebo	Placebo	NNP
cord-299731-sis9952k	442	62	-	-	HYPH
cord-299731-sis9952k	442	63	controlled	control	VBN
cord-299731-sis9952k	442	64	Clinical	Clinical	NNP
cord-299731-sis9952k	442	65	Trial	Trial	NNP
cord-299731-sis9952k	442	66	of	of	IN
cord-299731-sis9952k	442	67	Healthy	Healthy	NNP
cord-299731-sis9952k	442	68	Overweight	Overweight	NNP
cord-299731-sis9952k	442	69	Adults	Adults	NNPS
cord-299731-sis9952k	443	1	Repeat	repeat	VB
cord-299731-sis9952k	444	1	dose	dose	JJ
cord-299731-sis9952k	444	2	NRPT	NRPT	NNP
cord-299731-sis9952k	444	3	(	(	-LRB-
cord-299731-sis9952k	444	4	nicotinamide	nicotinamide	JJ
cord-299731-sis9952k	444	5	riboside	riboside	NN
cord-299731-sis9952k	444	6	and	and	CC
cord-299731-sis9952k	444	7	pterostilbene	pterostilbene	NN
cord-299731-sis9952k	444	8	)	)	-RRB-
cord-299731-sis9952k	444	9	increases	increase	VBZ
cord-299731-sis9952k	444	10	NAD+	NAD+	NNP
cord-299731-sis9952k	444	11	levels	level	NNS
cord-299731-sis9952k	444	12	in	in	IN
cord-299731-sis9952k	444	13	humans	human	NNS
cord-299731-sis9952k	444	14	safely	safely	RB
cord-299731-sis9952k	444	15	and	and	CC
cord-299731-sis9952k	444	16	sustainably	sustainably	RB
cord-299731-sis9952k	444	17	:	:	:
cord-299731-sis9952k	444	18	A	a	DT
cord-299731-sis9952k	444	19	randomized	randomized	JJ
cord-299731-sis9952k	444	20	,	,	,
cord-299731-sis9952k	444	21	double	double	JJ
cord-299731-sis9952k	444	22	-	-	HYPH
cord-299731-sis9952k	444	23	blind	blind	JJ
cord-299731-sis9952k	444	24	,	,	,
cord-299731-sis9952k	444	25	placebo	placebo	NN
cord-299731-sis9952k	444	26	-	-	HYPH
cord-299731-sis9952k	444	27	controlled	control	VBN
cord-299731-sis9952k	444	28	study	study	NN
cord-299731-sis9952k	444	29	Acute	Acute	NNP
cord-299731-sis9952k	444	30	nicotinamide	nicotinamide	NNP
cord-299731-sis9952k	445	1	riboside	riboside	JJ
cord-299731-sis9952k	445	2	supplementation	supplementation	NN
cord-299731-sis9952k	445	3	improves	improve	VBZ
cord-299731-sis9952k	445	4	redox	redox	JJ
cord-299731-sis9952k	445	5	homeostasis	homeostasis	NN
cord-299731-sis9952k	445	6	and	and	CC
cord-299731-sis9952k	445	7	exercise	exercise	NN
cord-299731-sis9952k	445	8	performance	performance	NN
cord-299731-sis9952k	445	9	in	in	IN
cord-299731-sis9952k	445	10	old	old	JJ
cord-299731-sis9952k	445	11	individuals	individual	NNS
cord-299731-sis9952k	445	12	:	:	:
cord-299731-sis9952k	445	13	A	a	DT
cord-299731-sis9952k	445	14	double	double	JJ
cord-299731-sis9952k	445	15	-	-	HYPH
cord-299731-sis9952k	445	16	blind	blind	JJ
cord-299731-sis9952k	445	17	cross	cross	NN
cord-299731-sis9952k	445	18	-	-	HYPH
cord-299731-sis9952k	445	19	over	over	RP
cord-299731-sis9952k	445	20	study	study	NN