id sid tid token lemma pos cord-333286-lr32e0w4 1 1 key key JJ cord-333286-lr32e0w4 1 2 : : : cord-333286-lr32e0w4 1 3 cord-333286-lr32e0w4 cord-333286-lr32e0w4 NN cord-333286-lr32e0w4 1 4 authors author NNS cord-333286-lr32e0w4 1 5 : : : cord-333286-lr32e0w4 1 6 Lehtoranta Lehtoranta NNP cord-333286-lr32e0w4 1 7 , , , cord-333286-lr32e0w4 1 8 Liisa Liisa NNP cord-333286-lr32e0w4 1 9 ; ; : cord-333286-lr32e0w4 1 10 Latvala Latvala NNP cord-333286-lr32e0w4 1 11 , , , cord-333286-lr32e0w4 1 12 Sinikka Sinikka NNP cord-333286-lr32e0w4 1 13 ; ; : cord-333286-lr32e0w4 1 14 Lehtinen Lehtinen NNP cord-333286-lr32e0w4 1 15 , , , cord-333286-lr32e0w4 1 16 Markus Markus NNP cord-333286-lr32e0w4 1 17 J. J. NNP cord-333286-lr32e0w4 2 1 title title NN cord-333286-lr32e0w4 2 2 : : : cord-333286-lr32e0w4 2 3 Role role NN cord-333286-lr32e0w4 2 4 of of IN cord-333286-lr32e0w4 2 5 Probiotics probiotic NNS cord-333286-lr32e0w4 2 6 in in IN cord-333286-lr32e0w4 2 7 Stimulating stimulate VBG cord-333286-lr32e0w4 2 8 the the DT cord-333286-lr32e0w4 2 9 Immune Immune NNP cord-333286-lr32e0w4 2 10 System System NNP cord-333286-lr32e0w4 2 11 in in IN cord-333286-lr32e0w4 2 12 Viral Viral NNP cord-333286-lr32e0w4 2 13 Respiratory respiratory JJ cord-333286-lr32e0w4 2 14 Tract Tract NNP cord-333286-lr32e0w4 2 15 Infections infection NNS cord-333286-lr32e0w4 2 16 : : : cord-333286-lr32e0w4 3 1 A a DT cord-333286-lr32e0w4 3 2 Narrative Narrative NNP cord-333286-lr32e0w4 3 3 Review Review NNP cord-333286-lr32e0w4 3 4 date date NN cord-333286-lr32e0w4 3 5 : : : cord-333286-lr32e0w4 3 6 2020 2020 CD cord-333286-lr32e0w4 3 7 - - SYM cord-333286-lr32e0w4 3 8 10 10 CD cord-333286-lr32e0w4 3 9 - - SYM cord-333286-lr32e0w4 3 10 16 16 CD cord-333286-lr32e0w4 3 11 journal journal NN cord-333286-lr32e0w4 3 12 : : : cord-333286-lr32e0w4 4 1 Nutrients nutrient NNS cord-333286-lr32e0w4 4 2 DOI DOI NNP cord-333286-lr32e0w4 4 3 : : : cord-333286-lr32e0w4 5 1 10.3390 10.3390 CD cord-333286-lr32e0w4 5 2 / / SYM cord-333286-lr32e0w4 5 3 nu12103163 nu12103163 NNP cord-333286-lr32e0w4 5 4 sha sha NNP cord-333286-lr32e0w4 5 5 : : : cord-333286-lr32e0w4 5 6 17325e3d3de92e3181c0837fabff73304d6a2a70 17325e3d3de92e3181c0837fabff73304d6a2a70 CD cord-333286-lr32e0w4 5 7 doc_id doc_id CD cord-333286-lr32e0w4 5 8 : : : cord-333286-lr32e0w4 5 9 333286 333286 CD cord-333286-lr32e0w4 5 10 cord_uid cord_uid NNS cord-333286-lr32e0w4 5 11 : : : cord-333286-lr32e0w4 5 12 lr32e0w4 lr32e0w4 NNP cord-333286-lr32e0w4 5 13 Viral Viral NNP cord-333286-lr32e0w4 5 14 respiratory respiratory JJ cord-333286-lr32e0w4 5 15 tract tract NN cord-333286-lr32e0w4 5 16 infection infection NN cord-333286-lr32e0w4 5 17 ( ( -LRB- cord-333286-lr32e0w4 5 18 RTI RTI NNP cord-333286-lr32e0w4 5 19 ) ) -RRB- cord-333286-lr32e0w4 5 20 is be VBZ cord-333286-lr32e0w4 5 21 the the DT cord-333286-lr32e0w4 5 22 most most RBS cord-333286-lr32e0w4 5 23 frequent frequent JJ cord-333286-lr32e0w4 5 24 cause cause NN cord-333286-lr32e0w4 5 25 of of IN cord-333286-lr32e0w4 5 26 infectious infectious JJ cord-333286-lr32e0w4 5 27 illnesses illness NNS cord-333286-lr32e0w4 5 28 including include VBG cord-333286-lr32e0w4 5 29 the the DT cord-333286-lr32e0w4 5 30 common common JJ cord-333286-lr32e0w4 5 31 cold cold NN cord-333286-lr32e0w4 5 32 . . . cord-333286-lr32e0w4 6 1 Pharmacological pharmacological JJ cord-333286-lr32e0w4 6 2 solutions solution NNS cord-333286-lr32e0w4 6 3 for for IN cord-333286-lr32e0w4 6 4 treating treat VBG cord-333286-lr32e0w4 6 5 or or CC cord-333286-lr32e0w4 6 6 preventing prevent VBG cord-333286-lr32e0w4 6 7 viral viral JJ cord-333286-lr32e0w4 6 8 RTIs rti NNS cord-333286-lr32e0w4 6 9 are be VBP cord-333286-lr32e0w4 6 10 so so RB cord-333286-lr32e0w4 6 11 far far RB cord-333286-lr32e0w4 6 12 limited limited JJ cord-333286-lr32e0w4 6 13 and and CC cord-333286-lr32e0w4 6 14 thus thus RB cord-333286-lr32e0w4 6 15 several several JJ cord-333286-lr32e0w4 6 16 self self NN cord-333286-lr32e0w4 6 17 - - HYPH cord-333286-lr32e0w4 6 18 care care NN cord-333286-lr32e0w4 6 19 products product NNS cord-333286-lr32e0w4 6 20 are be VBP cord-333286-lr32e0w4 6 21 available available JJ cord-333286-lr32e0w4 6 22 in in IN cord-333286-lr32e0w4 6 23 the the DT cord-333286-lr32e0w4 6 24 market market NN cord-333286-lr32e0w4 6 25 . . . cord-333286-lr32e0w4 7 1 Some some DT cord-333286-lr32e0w4 7 2 dietary dietary JJ cord-333286-lr32e0w4 7 3 supplements supplement NNS cord-333286-lr32e0w4 7 4 such such JJ cord-333286-lr32e0w4 7 5 as as IN cord-333286-lr32e0w4 7 6 probiotics probiotic NNS cord-333286-lr32e0w4 7 7 have have VBP cord-333286-lr32e0w4 7 8 been be VBN cord-333286-lr32e0w4 7 9 shown show VBN cord-333286-lr32e0w4 7 10 to to TO cord-333286-lr32e0w4 7 11 modulate modulate VB cord-333286-lr32e0w4 7 12 immune immune JJ cord-333286-lr32e0w4 7 13 system system NN cord-333286-lr32e0w4 7 14 function function NN cord-333286-lr32e0w4 7 15 and and CC cord-333286-lr32e0w4 7 16 their -PRON- PRP$ cord-333286-lr32e0w4 7 17 role role NN cord-333286-lr32e0w4 7 18 in in IN cord-333286-lr32e0w4 7 19 reducing reduce VBG cord-333286-lr32e0w4 7 20 the the DT cord-333286-lr32e0w4 7 21 risk risk NN cord-333286-lr32e0w4 7 22 and and CC cord-333286-lr32e0w4 7 23 the the DT cord-333286-lr32e0w4 7 24 course course NN cord-333286-lr32e0w4 7 25 of of IN cord-333286-lr32e0w4 7 26 RTIs rti NNS cord-333286-lr32e0w4 7 27 has have VBZ cord-333286-lr32e0w4 7 28 been be VBN cord-333286-lr32e0w4 7 29 investigated investigate VBN cord-333286-lr32e0w4 7 30 extensively extensively RB cord-333286-lr32e0w4 7 31 within within IN cord-333286-lr32e0w4 7 32 the the DT cord-333286-lr32e0w4 7 33 past past JJ cord-333286-lr32e0w4 7 34 decade decade NN cord-333286-lr32e0w4 7 35 . . . cord-333286-lr32e0w4 8 1 However however RB cord-333286-lr32e0w4 8 2 , , , cord-333286-lr32e0w4 8 3 the the DT cord-333286-lr32e0w4 8 4 mechanism mechanism NN cord-333286-lr32e0w4 8 5 of of IN cord-333286-lr32e0w4 8 6 action action NN cord-333286-lr32e0w4 8 7 and and CC cord-333286-lr32e0w4 8 8 the the DT cord-333286-lr32e0w4 8 9 efficacy efficacy NN cord-333286-lr32e0w4 8 10 of of IN cord-333286-lr32e0w4 8 11 probiotics probiotic NNS cord-333286-lr32e0w4 8 12 against against IN cord-333286-lr32e0w4 8 13 viral viral JJ cord-333286-lr32e0w4 8 14 RTIs rti NNS cord-333286-lr32e0w4 8 15 remains remain VBZ cord-333286-lr32e0w4 8 16 unclear unclear JJ cord-333286-lr32e0w4 8 17 . . . cord-333286-lr32e0w4 9 1 We -PRON- PRP cord-333286-lr32e0w4 9 2 searched search VBD cord-333286-lr32e0w4 9 3 PubMed PubMed NNP cord-333286-lr32e0w4 9 4 , , , cord-333286-lr32e0w4 9 5 Google Google NNP cord-333286-lr32e0w4 9 6 Scholar Scholar NNP cord-333286-lr32e0w4 9 7 , , , cord-333286-lr32e0w4 9 8 and and CC cord-333286-lr32e0w4 9 9 Web web NN cord-333286-lr32e0w4 9 10 of of IN cord-333286-lr32e0w4 9 11 Knowledge Knowledge NNP cord-333286-lr32e0w4 9 12 for for IN cord-333286-lr32e0w4 9 13 pre pre JJ cord-333286-lr32e0w4 9 14 - - JJ cord-333286-lr32e0w4 9 15 clinical clinical JJ cord-333286-lr32e0w4 9 16 and and CC cord-333286-lr32e0w4 9 17 clinical clinical JJ cord-333286-lr32e0w4 9 18 studies study NNS cord-333286-lr32e0w4 9 19 investigating investigate VBG cord-333286-lr32e0w4 9 20 the the DT cord-333286-lr32e0w4 9 21 effect effect NN cord-333286-lr32e0w4 9 22 of of IN cord-333286-lr32e0w4 9 23 probiotics probiotic NNS cord-333286-lr32e0w4 9 24 on on IN cord-333286-lr32e0w4 9 25 respiratory respiratory JJ cord-333286-lr32e0w4 9 26 virus virus NN cord-333286-lr32e0w4 9 27 infections infection NNS cord-333286-lr32e0w4 9 28 , , , cord-333286-lr32e0w4 9 29 immune immune JJ cord-333286-lr32e0w4 9 30 response response NN cord-333286-lr32e0w4 9 31 , , , cord-333286-lr32e0w4 9 32 and and CC cord-333286-lr32e0w4 9 33 the the DT cord-333286-lr32e0w4 9 34 course course NN cord-333286-lr32e0w4 9 35 of of IN cord-333286-lr32e0w4 9 36 upper upper JJ cord-333286-lr32e0w4 9 37 and and CC cord-333286-lr32e0w4 9 38 lower low JJR cord-333286-lr32e0w4 9 39 respiratory respiratory JJ cord-333286-lr32e0w4 9 40 tract tract NN cord-333286-lr32e0w4 9 41 illness illness NN cord-333286-lr32e0w4 9 42 . . . cord-333286-lr32e0w4 10 1 The the DT cord-333286-lr32e0w4 10 2 literature literature NN cord-333286-lr32e0w4 10 3 summarized summarize VBD cord-333286-lr32e0w4 10 4 in in IN cord-333286-lr32e0w4 10 5 this this DT cord-333286-lr32e0w4 10 6 narrative narrative NN cord-333286-lr32e0w4 10 7 review review NN cord-333286-lr32e0w4 10 8 points point VBZ cord-333286-lr32e0w4 10 9 out out RP cord-333286-lr32e0w4 10 10 that that IN cord-333286-lr32e0w4 10 11 specific specific JJ cord-333286-lr32e0w4 10 12 probiotic probiotic JJ cord-333286-lr32e0w4 10 13 strains strain NNS cord-333286-lr32e0w4 10 14 seem seem VBP cord-333286-lr32e0w4 10 15 effective effective JJ cord-333286-lr32e0w4 10 16 in in IN cord-333286-lr32e0w4 10 17 pre pre JJ cord-333286-lr32e0w4 10 18 - - JJ cord-333286-lr32e0w4 10 19 clinical clinical JJ cord-333286-lr32e0w4 10 20 models model NNS cord-333286-lr32e0w4 10 21 , , , cord-333286-lr32e0w4 10 22 through through IN cord-333286-lr32e0w4 10 23 stimulating stimulate VBG cord-333286-lr32e0w4 10 24 the the DT cord-333286-lr32e0w4 10 25 immune immune JJ cord-333286-lr32e0w4 10 26 system system NN cord-333286-lr32e0w4 10 27 and and CC cord-333286-lr32e0w4 10 28 inhibiting inhibit VBG cord-333286-lr32e0w4 10 29 viral viral JJ cord-333286-lr32e0w4 10 30 replication replication NN cord-333286-lr32e0w4 10 31 . . . cord-333286-lr32e0w4 11 1 Clinical clinical JJ cord-333286-lr32e0w4 11 2 studies study NNS cord-333286-lr32e0w4 11 3 indicate indicate VBP cord-333286-lr32e0w4 11 4 variable variable JJ cord-333286-lr32e0w4 11 5 efficacy efficacy NN cord-333286-lr32e0w4 11 6 on on IN cord-333286-lr32e0w4 11 7 upper upper JJ cord-333286-lr32e0w4 11 8 respiratory respiratory JJ cord-333286-lr32e0w4 11 9 illnesses illness NNS cord-333286-lr32e0w4 11 10 and and CC cord-333286-lr32e0w4 11 11 lack lack VBP cord-333286-lr32e0w4 11 12 proof proof NN cord-333286-lr32e0w4 11 13 of of IN cord-333286-lr32e0w4 11 14 diagnosed diagnose VBN cord-333286-lr32e0w4 11 15 viral viral JJ cord-333286-lr32e0w4 11 16 infections infection NNS cord-333286-lr32e0w4 11 17 . . . cord-333286-lr32e0w4 12 1 However however RB cord-333286-lr32e0w4 12 2 , , , cord-333286-lr32e0w4 12 3 meta meta NNP cord-333286-lr32e0w4 12 4 - - HYPH cord-333286-lr32e0w4 12 5 analyses analysis NNS cord-333286-lr32e0w4 12 6 of of IN cord-333286-lr32e0w4 12 7 clinical clinical JJ cord-333286-lr32e0w4 12 8 studies study NNS cord-333286-lr32e0w4 12 9 indicate indicate VBP cord-333286-lr32e0w4 12 10 that that IN cord-333286-lr32e0w4 12 11 probiotics probiotic NNS cord-333286-lr32e0w4 12 12 could could MD cord-333286-lr32e0w4 12 13 be be VB cord-333286-lr32e0w4 12 14 beneficial beneficial JJ cord-333286-lr32e0w4 12 15 in in IN cord-333286-lr32e0w4 12 16 upper upper JJ cord-333286-lr32e0w4 12 17 respiratory respiratory JJ cord-333286-lr32e0w4 12 18 illnesses illness NNS cord-333286-lr32e0w4 12 19 without without IN cord-333286-lr32e0w4 12 20 specific specific JJ cord-333286-lr32e0w4 12 21 etiology etiology NN cord-333286-lr32e0w4 12 22 . . . cord-333286-lr32e0w4 13 1 Further further JJ cord-333286-lr32e0w4 13 2 studies study NNS cord-333286-lr32e0w4 13 3 aiming aim VBG cord-333286-lr32e0w4 13 4 at at IN cord-333286-lr32e0w4 13 5 discovering discover VBG cord-333286-lr32e0w4 13 6 the the DT cord-333286-lr32e0w4 13 7 mechanisms mechanism NNS cord-333286-lr32e0w4 13 8 of of IN cord-333286-lr32e0w4 13 9 action action NN cord-333286-lr32e0w4 13 10 of of IN cord-333286-lr32e0w4 13 11 probiotics probiotic NNS cord-333286-lr32e0w4 13 12 and and CC cord-333286-lr32e0w4 13 13 clinical clinical JJ cord-333286-lr32e0w4 13 14 efficacy efficacy NN cord-333286-lr32e0w4 13 15 are be VBP cord-333286-lr32e0w4 13 16 warranted warrant VBN cord-333286-lr32e0w4 13 17 . . . cord-333286-lr32e0w4 14 1 Respiratory respiratory JJ cord-333286-lr32e0w4 14 2 viruses virus NNS cord-333286-lr32e0w4 14 3 cause cause VBP cord-333286-lr32e0w4 14 4 the the DT cord-333286-lr32e0w4 14 5 most most RBS cord-333286-lr32e0w4 14 6 common common JJ cord-333286-lr32e0w4 14 7 infectious infectious JJ cord-333286-lr32e0w4 14 8 illnesses illness NNS cord-333286-lr32e0w4 14 9 in in IN cord-333286-lr32e0w4 14 10 humans human NNS cord-333286-lr32e0w4 14 11 - - HYPH cord-333286-lr32e0w4 14 12 acute acute JJ cord-333286-lr32e0w4 14 13 RTIs rti NNS cord-333286-lr32e0w4 14 14 that that WDT cord-333286-lr32e0w4 14 15 can can MD cord-333286-lr32e0w4 14 16 be be VB cord-333286-lr32e0w4 14 17 divided divide VBN cord-333286-lr32e0w4 14 18 into into IN cord-333286-lr32e0w4 14 19 upper upper JJ cord-333286-lr32e0w4 14 20 RTIs rti NNS cord-333286-lr32e0w4 14 21 ( ( -LRB- cord-333286-lr32e0w4 14 22 URTI URTI NNP cord-333286-lr32e0w4 14 23 ) ) -RRB- cord-333286-lr32e0w4 14 24 , , , cord-333286-lr32e0w4 14 25 e.g. e.g. RB cord-333286-lr32e0w4 14 26 , , , cord-333286-lr32e0w4 14 27 the the DT cord-333286-lr32e0w4 14 28 common common JJ cord-333286-lr32e0w4 14 29 cold cold NN cord-333286-lr32e0w4 14 30 , , , cord-333286-lr32e0w4 14 31 and and CC cord-333286-lr32e0w4 14 32 lower low JJR cord-333286-lr32e0w4 14 33 RTIs rti NNS cord-333286-lr32e0w4 14 34 ( ( -LRB- cord-333286-lr32e0w4 14 35 LRTI LRTI NNP cord-333286-lr32e0w4 14 36 ) ) -RRB- cord-333286-lr32e0w4 14 37 , , , cord-333286-lr32e0w4 14 38 e.g. e.g. RB cord-333286-lr32e0w4 14 39 , , , cord-333286-lr32e0w4 14 40 bronchitis bronchitis NN cord-333286-lr32e0w4 14 41 and and CC cord-333286-lr32e0w4 14 42 pneumonia pneumonia NN cord-333286-lr32e0w4 14 43 . . . cord-333286-lr32e0w4 15 1 These these DT cord-333286-lr32e0w4 15 2 illnesses illness NNS cord-333286-lr32e0w4 15 3 affect affect VBP cord-333286-lr32e0w4 15 4 all all DT cord-333286-lr32e0w4 15 5 age age NN cord-333286-lr32e0w4 15 6 groups group NNS cord-333286-lr32e0w4 15 7 annually annually RB cord-333286-lr32e0w4 15 8 and and CC cord-333286-lr32e0w4 15 9 cause cause VB cord-333286-lr32e0w4 15 10 a a DT cord-333286-lr32e0w4 15 11 high high JJ cord-333286-lr32e0w4 15 12 burden burden NN cord-333286-lr32e0w4 15 13 on on IN cord-333286-lr32e0w4 15 14 health health NN cord-333286-lr32e0w4 15 15 care care NN cord-333286-lr32e0w4 15 16 systems system NNS cord-333286-lr32e0w4 15 17 and and CC cord-333286-lr32e0w4 15 18 global global JJ cord-333286-lr32e0w4 15 19 economics economic NNS cord-333286-lr32e0w4 15 20 due due JJ cord-333286-lr32e0w4 15 21 to to IN cord-333286-lr32e0w4 15 22 absenteeism absenteeism NN cord-333286-lr32e0w4 15 23 from from IN cord-333286-lr32e0w4 15 24 daycares daycare NNS cord-333286-lr32e0w4 15 25 , , , cord-333286-lr32e0w4 15 26 school school NN cord-333286-lr32e0w4 15 27 , , , cord-333286-lr32e0w4 15 28 and and CC cord-333286-lr32e0w4 15 29 work work NN cord-333286-lr32e0w4 15 30 . . . cord-333286-lr32e0w4 16 1 Over over IN cord-333286-lr32e0w4 16 2 200 200 CD cord-333286-lr32e0w4 16 3 virus virus NN cord-333286-lr32e0w4 16 4 types type NNS cord-333286-lr32e0w4 16 5 have have VBP cord-333286-lr32e0w4 16 6 been be VBN cord-333286-lr32e0w4 16 7 identified identify VBN cord-333286-lr32e0w4 16 8 as as IN cord-333286-lr32e0w4 16 9 causative causative JJ cord-333286-lr32e0w4 16 10 agents agent NNS cord-333286-lr32e0w4 16 11 for for IN cord-333286-lr32e0w4 16 12 respiratory respiratory JJ cord-333286-lr32e0w4 16 13 illnesses illness NNS cord-333286-lr32e0w4 16 14 [ [ -LRB- cord-333286-lr32e0w4 16 15 1 1 CD cord-333286-lr32e0w4 16 16 , , , cord-333286-lr32e0w4 16 17 2 2 CD cord-333286-lr32e0w4 16 18 ] ] -RRB- cord-333286-lr32e0w4 16 19 . . . cord-333286-lr32e0w4 17 1 In in IN cord-333286-lr32e0w4 17 2 most most JJS cord-333286-lr32e0w4 17 3 cases case NNS cord-333286-lr32e0w4 17 4 , , , cord-333286-lr32e0w4 17 5 especially especially RB cord-333286-lr32e0w4 17 6 illnesses illness NNS cord-333286-lr32e0w4 17 7 of of IN cord-333286-lr32e0w4 17 8 the the DT cord-333286-lr32e0w4 17 9 upper upper JJ cord-333286-lr32e0w4 17 10 respiratory respiratory JJ cord-333286-lr32e0w4 17 11 tract tract NN cord-333286-lr32e0w4 17 12 are be VBP cord-333286-lr32e0w4 17 13 mild mild JJ cord-333286-lr32e0w4 17 14 to to TO cord-333286-lr32e0w4 17 15 moderate moderate JJ cord-333286-lr32e0w4 17 16 and and CC cord-333286-lr32e0w4 17 17 often often RB cord-333286-lr32e0w4 17 18 self self NN cord-333286-lr32e0w4 17 19 - - HYPH cord-333286-lr32e0w4 17 20 limiting limit VBG cord-333286-lr32e0w4 17 21 . . . cord-333286-lr32e0w4 18 1 On on IN cord-333286-lr32e0w4 18 2 the the DT cord-333286-lr32e0w4 18 3 other other JJ cord-333286-lr32e0w4 18 4 hand hand NN cord-333286-lr32e0w4 18 5 , , , cord-333286-lr32e0w4 18 6 LRTIs lrtis VB cord-333286-lr32e0w4 18 7 leading lead VBG cord-333286-lr32e0w4 18 8 to to IN cord-333286-lr32e0w4 18 9 pneumonia pneumonia NN cord-333286-lr32e0w4 18 10 can can MD cord-333286-lr32e0w4 18 11 be be VB cord-333286-lr32e0w4 18 12 especially especially RB cord-333286-lr32e0w4 18 13 fatal fatal JJ cord-333286-lr32e0w4 18 14 among among IN cord-333286-lr32e0w4 18 15 children child NNS cord-333286-lr32e0w4 18 16 and and CC cord-333286-lr32e0w4 18 17 the the DT cord-333286-lr32e0w4 18 18 elderly elderly JJ cord-333286-lr32e0w4 18 19 , , , cord-333286-lr32e0w4 18 20 or or CC cord-333286-lr32e0w4 18 21 immunocompromised immunocompromised JJ cord-333286-lr32e0w4 18 22 subjects subject NNS cord-333286-lr32e0w4 18 23 [ [ -LRB- cord-333286-lr32e0w4 18 24 2 2 CD cord-333286-lr32e0w4 18 25 ] ] -RRB- cord-333286-lr32e0w4 18 26 . . . cord-333286-lr32e0w4 19 1 In in IN cord-333286-lr32e0w4 19 2 the the DT cord-333286-lr32e0w4 19 3 past past JJ cord-333286-lr32e0w4 19 4 decade decade NN cord-333286-lr32e0w4 19 5 , , , cord-333286-lr32e0w4 19 6 studies study NNS cord-333286-lr32e0w4 19 7 linking link VBG cord-333286-lr32e0w4 19 8 the the DT cord-333286-lr32e0w4 19 9 microbiota microbiota NN cord-333286-lr32e0w4 19 10 and and CC cord-333286-lr32e0w4 19 11 immune immune JJ cord-333286-lr32e0w4 19 12 system system NN cord-333286-lr32e0w4 19 13 function function NN cord-333286-lr32e0w4 19 14 have have VBP cord-333286-lr32e0w4 19 15 laid lay VBN cord-333286-lr32e0w4 19 16 the the DT cord-333286-lr32e0w4 19 17 foundation foundation NN cord-333286-lr32e0w4 19 18 for for IN cord-333286-lr32e0w4 19 19 the the DT cord-333286-lr32e0w4 19 20 opportunities opportunity NNS cord-333286-lr32e0w4 19 21 in in IN cord-333286-lr32e0w4 19 22 microbiota microbiota NN cord-333286-lr32e0w4 19 23 modulation modulation NN cord-333286-lr32e0w4 19 24 and and CC cord-333286-lr32e0w4 19 25 bacterial bacterial JJ cord-333286-lr32e0w4 19 26 therapeutics therapeutic NNS cord-333286-lr32e0w4 19 27 in in IN cord-333286-lr32e0w4 19 28 health health NN cord-333286-lr32e0w4 19 29 and and CC cord-333286-lr32e0w4 19 30 disease disease NN cord-333286-lr32e0w4 19 31 . . . cord-333286-lr32e0w4 20 1 Further further RB cord-333286-lr32e0w4 20 2 , , , cord-333286-lr32e0w4 20 3 studies study NNS cord-333286-lr32e0w4 20 4 have have VBP cord-333286-lr32e0w4 20 5 associated associate VBN cord-333286-lr32e0w4 20 6 the the DT cord-333286-lr32e0w4 20 7 gut gut NN cord-333286-lr32e0w4 20 8 and and CC cord-333286-lr32e0w4 20 9 airway airway NN cord-333286-lr32e0w4 20 10 microbiota microbiota NN cord-333286-lr32e0w4 20 11 with with IN cord-333286-lr32e0w4 20 12 upper upper JJ cord-333286-lr32e0w4 20 13 and and CC cord-333286-lr32e0w4 20 14 lower low JJR cord-333286-lr32e0w4 20 15 respiratory respiratory JJ cord-333286-lr32e0w4 20 16 tract tract NN cord-333286-lr32e0w4 20 17 health health NN cord-333286-lr32e0w4 20 18 and and CC cord-333286-lr32e0w4 20 19 immunity immunity NN cord-333286-lr32e0w4 20 20 [ [ -LRB- cord-333286-lr32e0w4 20 21 3 3 CD cord-333286-lr32e0w4 20 22 , , , cord-333286-lr32e0w4 20 23 4 4 CD cord-333286-lr32e0w4 20 24 ] ] -RRB- cord-333286-lr32e0w4 20 25 . . . cord-333286-lr32e0w4 21 1 Thus thus RB cord-333286-lr32e0w4 21 2 , , , cord-333286-lr32e0w4 21 3 modulation modulation NN cord-333286-lr32e0w4 21 4 of of IN cord-333286-lr32e0w4 21 5 the the DT cord-333286-lr32e0w4 21 6 gut gut NN cord-333286-lr32e0w4 21 7 microbiota microbiota NN cord-333286-lr32e0w4 21 8 and and CC cord-333286-lr32e0w4 21 9 immunity immunity NN cord-333286-lr32e0w4 21 10 by by IN cord-333286-lr32e0w4 21 11 dietary dietary JJ cord-333286-lr32e0w4 21 12 supplements supplement NNS cord-333286-lr32e0w4 21 13 or or CC cord-333286-lr32e0w4 21 14 pharmaceuticals pharmaceutical NNS cord-333286-lr32e0w4 21 15 is be VBZ cord-333286-lr32e0w4 21 16 of of IN cord-333286-lr32e0w4 21 17 increasing increase VBG cord-333286-lr32e0w4 21 18 interest interest NN cord-333286-lr32e0w4 21 19 in in IN cord-333286-lr32e0w4 21 20 finding find VBG cord-333286-lr32e0w4 21 21 novel novel JJ cord-333286-lr32e0w4 21 22 solutions solution NNS cord-333286-lr32e0w4 21 23 to to TO cord-333286-lr32e0w4 21 24 manage manage VB cord-333286-lr32e0w4 21 25 RTIs rti NNS cord-333286-lr32e0w4 21 26 . . . cord-333286-lr32e0w4 22 1 Among among IN cord-333286-lr32e0w4 22 2 the the DT cord-333286-lr32e0w4 22 3 promising promising JJ cord-333286-lr32e0w4 22 4 candidates candidate NNS cord-333286-lr32e0w4 22 5 are be VBP cord-333286-lr32e0w4 22 6 probiotics probiotic NNS cord-333286-lr32e0w4 22 7 that that WDT cord-333286-lr32e0w4 22 8 have have VBP cord-333286-lr32e0w4 22 9 been be VBN cord-333286-lr32e0w4 22 10 studied study VBN cord-333286-lr32e0w4 22 11 for for IN cord-333286-lr32e0w4 22 12 immune immune JJ cord-333286-lr32e0w4 22 13 function function NN cord-333286-lr32e0w4 22 14 modulation modulation NN cord-333286-lr32e0w4 22 15 and and CC cord-333286-lr32e0w4 22 16 viral viral JJ cord-333286-lr32e0w4 22 17 infections infection NNS cord-333286-lr32e0w4 22 18 . . . cord-333286-lr32e0w4 23 1 Meta Meta NNP cord-333286-lr32e0w4 23 2 - - HYPH cord-333286-lr32e0w4 23 3 analyses analysis NNS cord-333286-lr32e0w4 23 4 suggest suggest VBP cord-333286-lr32e0w4 23 5 that that IN cord-333286-lr32e0w4 23 6 probiotics probiotic NNS cord-333286-lr32e0w4 23 7 could could MD cord-333286-lr32e0w4 23 8 be be VB cord-333286-lr32e0w4 23 9 beneficial beneficial JJ cord-333286-lr32e0w4 23 10 in in IN cord-333286-lr32e0w4 23 11 the the DT cord-333286-lr32e0w4 23 12 context context NN cord-333286-lr32e0w4 23 13 of of IN cord-333286-lr32e0w4 23 14 acute acute JJ cord-333286-lr32e0w4 23 15 URTI URTI NNP cord-333286-lr32e0w4 23 16 typically typically RB cord-333286-lr32e0w4 23 17 caused cause VBN cord-333286-lr32e0w4 23 18 by by IN cord-333286-lr32e0w4 23 19 viruses virus NNS cord-333286-lr32e0w4 23 20 [ [ -LRB- cord-333286-lr32e0w4 23 21 5 5 CD cord-333286-lr32e0w4 23 22 , , , cord-333286-lr32e0w4 23 23 6 6 CD cord-333286-lr32e0w4 23 24 ] ] -RRB- cord-333286-lr32e0w4 23 25 . . . cord-333286-lr32e0w4 24 1 Viruses virus NNS cord-333286-lr32e0w4 24 2 that that WDT cord-333286-lr32e0w4 24 3 cause cause VBP cord-333286-lr32e0w4 24 4 RTIs rti NNS cord-333286-lr32e0w4 24 5 are be VBP cord-333286-lr32e0w4 24 6 found find VBN cord-333286-lr32e0w4 24 7 in in IN cord-333286-lr32e0w4 24 8 various various JJ cord-333286-lr32e0w4 24 9 virus virus NN cord-333286-lr32e0w4 24 10 families family NNS cord-333286-lr32e0w4 24 11 , , , cord-333286-lr32e0w4 24 12 which which WDT cord-333286-lr32e0w4 24 13 differ differ VBP cord-333286-lr32e0w4 24 14 in in IN cord-333286-lr32e0w4 24 15 virulence virulence NN cord-333286-lr32e0w4 24 16 and and CC cord-333286-lr32e0w4 24 17 utilize utilize VB cord-333286-lr32e0w4 24 18 variable variable JJ cord-333286-lr32e0w4 24 19 strategies strategy NNS cord-333286-lr32e0w4 24 20 to to TO cord-333286-lr32e0w4 24 21 infect infect VB cord-333286-lr32e0w4 24 22 the the DT cord-333286-lr32e0w4 24 23 host host NN cord-333286-lr32e0w4 24 24 cells cell NNS cord-333286-lr32e0w4 24 25 and and CC cord-333286-lr32e0w4 24 26 to to TO cord-333286-lr32e0w4 24 27 evade evade VB cord-333286-lr32e0w4 24 28 the the DT cord-333286-lr32e0w4 24 29 host host NN cord-333286-lr32e0w4 24 30 immune immune JJ cord-333286-lr32e0w4 24 31 system system NN cord-333286-lr32e0w4 24 32 [ [ -LRB- cord-333286-lr32e0w4 24 33 14 14 CD cord-333286-lr32e0w4 24 34 , , , cord-333286-lr32e0w4 24 35 15 15 CD cord-333286-lr32e0w4 24 36 ] ] -RRB- cord-333286-lr32e0w4 24 37 . . . cord-333286-lr32e0w4 25 1 Respiratory respiratory JJ cord-333286-lr32e0w4 25 2 viruses virus NNS cord-333286-lr32e0w4 25 3 spread spread VBP cord-333286-lr32e0w4 25 4 via via IN cord-333286-lr32e0w4 25 5 nasal nasal NN cord-333286-lr32e0w4 25 6 secretions secretion NNS cord-333286-lr32e0w4 25 7 that that WDT cord-333286-lr32e0w4 25 8 can can MD cord-333286-lr32e0w4 25 9 be be VB cord-333286-lr32e0w4 25 10 transmitted transmit VBN cord-333286-lr32e0w4 25 11 through through IN cord-333286-lr32e0w4 25 12 the the DT cord-333286-lr32e0w4 25 13 air air NN cord-333286-lr32e0w4 25 14 or or CC cord-333286-lr32e0w4 25 15 by by IN cord-333286-lr32e0w4 25 16 hand hand NN cord-333286-lr32e0w4 25 17 - - HYPH cord-333286-lr32e0w4 25 18 to to TO cord-333286-lr32e0w4 25 19 hand hand VB cord-333286-lr32e0w4 25 20 and and CC cord-333286-lr32e0w4 25 21 surface surface NN cord-333286-lr32e0w4 25 22 - - HYPH cord-333286-lr32e0w4 25 23 to to IN cord-333286-lr32e0w4 25 24 - - HYPH cord-333286-lr32e0w4 25 25 hand hand NN cord-333286-lr32e0w4 25 26 contact contact NN cord-333286-lr32e0w4 25 27 [ [ -LRB- cord-333286-lr32e0w4 25 28 16 16 CD cord-333286-lr32e0w4 25 29 ] ] -RRB- cord-333286-lr32e0w4 25 30 . . . cord-333286-lr32e0w4 26 1 Infection infection NN cord-333286-lr32e0w4 26 2 requires require VBZ cord-333286-lr32e0w4 26 3 penetration penetration NN cord-333286-lr32e0w4 26 4 of of IN cord-333286-lr32e0w4 26 5 the the DT cord-333286-lr32e0w4 26 6 virus virus NN cord-333286-lr32e0w4 26 7 through through IN cord-333286-lr32e0w4 26 8 the the DT cord-333286-lr32e0w4 26 9 host host NN cord-333286-lr32e0w4 26 10 mucus mucus NN cord-333286-lr32e0w4 26 11 layer layer NN cord-333286-lr32e0w4 26 12 , , , cord-333286-lr32e0w4 26 13 including include VBG cord-333286-lr32e0w4 26 14 the the DT cord-333286-lr32e0w4 26 15 microbiota microbiota NN cord-333286-lr32e0w4 26 16 , , , cord-333286-lr32e0w4 26 17 and and CC cord-333286-lr32e0w4 26 18 antiviral antiviral JJ cord-333286-lr32e0w4 26 19 molecules molecule NNS cord-333286-lr32e0w4 26 20 in in IN cord-333286-lr32e0w4 26 21 the the DT cord-333286-lr32e0w4 26 22 mucus mucus NN cord-333286-lr32e0w4 26 23 , , , cord-333286-lr32e0w4 26 24 such such JJ cord-333286-lr32e0w4 26 25 as as IN cord-333286-lr32e0w4 26 26 antibodies antibody NNS cord-333286-lr32e0w4 26 27 and and CC cord-333286-lr32e0w4 26 28 collectins collectin NNS cord-333286-lr32e0w4 26 29 . . . cord-333286-lr32e0w4 27 1 Once once RB cord-333286-lr32e0w4 27 2 on on IN cord-333286-lr32e0w4 27 3 the the DT cord-333286-lr32e0w4 27 4 mucosal mucosal JJ cord-333286-lr32e0w4 27 5 epithelial epithelial JJ cord-333286-lr32e0w4 27 6 cells cell NNS cord-333286-lr32e0w4 27 7 , , , cord-333286-lr32e0w4 27 8 respiratory respiratory JJ cord-333286-lr32e0w4 27 9 viruses virus NNS cord-333286-lr32e0w4 27 10 attach attach VBP cord-333286-lr32e0w4 27 11 to to IN cord-333286-lr32e0w4 27 12 specific specific JJ cord-333286-lr32e0w4 27 13 receptors receptor NNS cord-333286-lr32e0w4 27 14 , , , cord-333286-lr32e0w4 27 15 such such JJ cord-333286-lr32e0w4 27 16 as as IN cord-333286-lr32e0w4 27 17 Intercellular Intercellular NNP cord-333286-lr32e0w4 27 18 Adhesion Adhesion NNP cord-333286-lr32e0w4 27 19 Molecule Molecule NNP cord-333286-lr32e0w4 27 20 ( ( -LRB- cord-333286-lr32e0w4 27 21 ICAM)-1 ICAM)-1 NNP cord-333286-lr32e0w4 27 22 ( ( -LRB- cord-333286-lr32e0w4 27 23 rhinoviruses rhinovirus NNS cord-333286-lr32e0w4 27 24 ) ) -RRB- cord-333286-lr32e0w4 27 25 , , , cord-333286-lr32e0w4 27 26 peptidases peptidases FW cord-333286-lr32e0w4 27 27 ( ( -LRB- cord-333286-lr32e0w4 27 28 coronaviruses coronaviruses NNP cord-333286-lr32e0w4 27 29 ) ) -RRB- cord-333286-lr32e0w4 27 30 , , , cord-333286-lr32e0w4 27 31 or or CC cord-333286-lr32e0w4 27 32 sialic sialic JJ cord-333286-lr32e0w4 27 33 acids acid NNS cord-333286-lr32e0w4 27 34 ( ( -LRB- cord-333286-lr32e0w4 27 35 influenza influenza NN cord-333286-lr32e0w4 27 36 viruses virus NNS cord-333286-lr32e0w4 27 37 ) ) -RRB- cord-333286-lr32e0w4 27 38 , , , cord-333286-lr32e0w4 27 39 that that WDT cord-333286-lr32e0w4 27 40 mediate mediate VBP cord-333286-lr32e0w4 27 41 the the DT cord-333286-lr32e0w4 27 42 internalization internalization NN cord-333286-lr32e0w4 27 43 of of IN cord-333286-lr32e0w4 27 44 the the DT cord-333286-lr32e0w4 27 45 virus virus NN cord-333286-lr32e0w4 27 46 by by IN cord-333286-lr32e0w4 27 47 endocytosis endocytosis NN cord-333286-lr32e0w4 27 48 [ [ -LRB- cord-333286-lr32e0w4 27 49 17 17 CD cord-333286-lr32e0w4 27 50 , , , cord-333286-lr32e0w4 27 51 18 18 CD cord-333286-lr32e0w4 27 52 ] ] -RRB- cord-333286-lr32e0w4 27 53 . . . cord-333286-lr32e0w4 28 1 The the DT cord-333286-lr32e0w4 28 2 viral viral JJ cord-333286-lr32e0w4 28 3 receptors receptor NNS cord-333286-lr32e0w4 28 4 are be VBP cord-333286-lr32e0w4 28 5 differentially differentially RB cord-333286-lr32e0w4 28 6 expressed express VBN cord-333286-lr32e0w4 28 7 on on IN cord-333286-lr32e0w4 28 8 host host NN cord-333286-lr32e0w4 28 9 cells cell NNS cord-333286-lr32e0w4 28 10 resulting result VBG cord-333286-lr32e0w4 28 11 in in IN cord-333286-lr32e0w4 28 12 virus virus NN cord-333286-lr32e0w4 28 13 - - HYPH cord-333286-lr32e0w4 28 14 specific specific JJ cord-333286-lr32e0w4 28 15 host host NN cord-333286-lr32e0w4 28 16 cell cell NN cord-333286-lr32e0w4 28 17 tropism tropism NN cord-333286-lr32e0w4 28 18 that that WDT cord-333286-lr32e0w4 28 19 is be VBZ cord-333286-lr32e0w4 28 20 one one CD cord-333286-lr32e0w4 28 21 key key JJ cord-333286-lr32e0w4 28 22 factor factor NN cord-333286-lr32e0w4 28 23 in in IN cord-333286-lr32e0w4 28 24 viral viral JJ cord-333286-lr32e0w4 28 25 pathogenesis pathogenesis NN cord-333286-lr32e0w4 28 26 . . . cord-333286-lr32e0w4 29 1 For for IN cord-333286-lr32e0w4 29 2 example example NN cord-333286-lr32e0w4 29 3 , , , cord-333286-lr32e0w4 29 4 influenza influenza NN cord-333286-lr32e0w4 29 5 viruses virus NNS cord-333286-lr32e0w4 29 6 typically typically RB cord-333286-lr32e0w4 29 7 infect infect VBP cord-333286-lr32e0w4 29 8 bronchial bronchial JJ cord-333286-lr32e0w4 29 9 cells cell NNS cord-333286-lr32e0w4 29 10 , , , cord-333286-lr32e0w4 29 11 whereas whereas IN cord-333286-lr32e0w4 29 12 rhinoviruses rhinovirus NNS cord-333286-lr32e0w4 29 13 infect infect VBP cord-333286-lr32e0w4 29 14 the the DT cord-333286-lr32e0w4 29 15 epithelial epithelial JJ cord-333286-lr32e0w4 29 16 cells cell NNS cord-333286-lr32e0w4 29 17 of of IN cord-333286-lr32e0w4 29 18 the the DT cord-333286-lr32e0w4 29 19 upper upper JJ cord-333286-lr32e0w4 29 20 airways airways NNP cord-333286-lr32e0w4 29 21 , , , cord-333286-lr32e0w4 29 22 resulting result VBG cord-333286-lr32e0w4 29 23 in in IN cord-333286-lr32e0w4 29 24 differences difference NNS cord-333286-lr32e0w4 29 25 in in IN cord-333286-lr32e0w4 29 26 illness illness NN cord-333286-lr32e0w4 29 27 presentation presentation NN cord-333286-lr32e0w4 29 28 . . . cord-333286-lr32e0w4 30 1 Viral viral JJ cord-333286-lr32e0w4 30 2 genomic genomic JJ cord-333286-lr32e0w4 30 3 structure structure NN cord-333286-lr32e0w4 30 4 can can MD cord-333286-lr32e0w4 30 5 be be VB cord-333286-lr32e0w4 30 6 , , , cord-333286-lr32e0w4 30 7 for for IN cord-333286-lr32e0w4 30 8 example example NN cord-333286-lr32e0w4 30 9 , , , cord-333286-lr32e0w4 30 10 positive positive JJ cord-333286-lr32e0w4 30 11 - - HYPH cord-333286-lr32e0w4 30 12 or or CC cord-333286-lr32e0w4 30 13 negative negative JJ cord-333286-lr32e0w4 30 14 - - HYPH cord-333286-lr32e0w4 30 15 sense sense NN cord-333286-lr32e0w4 30 16 single single JJ cord-333286-lr32e0w4 30 17 - - HYPH cord-333286-lr32e0w4 30 18 stranded stranded JJ cord-333286-lr32e0w4 30 19 ( ( -LRB- cord-333286-lr32e0w4 30 20 ss ss NNP cord-333286-lr32e0w4 30 21 ) ) -RRB- cord-333286-lr32e0w4 30 22 or or CC cord-333286-lr32e0w4 30 23 double double RB cord-333286-lr32e0w4 30 24 - - HYPH cord-333286-lr32e0w4 30 25 stranded stranded JJ cord-333286-lr32e0w4 30 26 ( ( -LRB- cord-333286-lr32e0w4 30 27 ds ds NNP cord-333286-lr32e0w4 30 28 ) ) -RRB- cord-333286-lr32e0w4 30 29 RNA RNA NNP cord-333286-lr32e0w4 30 30 or or CC cord-333286-lr32e0w4 30 31 DNA DNA NNP cord-333286-lr32e0w4 30 32 [ [ -LRB- cord-333286-lr32e0w4 30 33 19 19 CD cord-333286-lr32e0w4 30 34 ] ] -RRB- cord-333286-lr32e0w4 30 35 . . . cord-333286-lr32e0w4 31 1 Most Most JJS cord-333286-lr32e0w4 31 2 RTI RTI NNP cord-333286-lr32e0w4 31 3 causing cause VBG cord-333286-lr32e0w4 31 4 viruses virus NNS cord-333286-lr32e0w4 31 5 , , , cord-333286-lr32e0w4 31 6 picornaviruses picornavirus NNS cord-333286-lr32e0w4 31 7 , , , cord-333286-lr32e0w4 31 8 influenza influenza NN cord-333286-lr32e0w4 31 9 viruses virus NNS cord-333286-lr32e0w4 31 10 , , , cord-333286-lr32e0w4 31 11 and and CC cord-333286-lr32e0w4 31 12 coronaviruses coronaviruse NNS cord-333286-lr32e0w4 31 13 are be VBP cord-333286-lr32e0w4 31 14 ssRNA ssRNA VBG cord-333286-lr32e0w4 31 15 viruses virus NNS cord-333286-lr32e0w4 31 16 , , , cord-333286-lr32e0w4 31 17 whereas whereas IN cord-333286-lr32e0w4 31 18 adenoviruses adenovirus NNS cord-333286-lr32e0w4 31 19 are be VBP cord-333286-lr32e0w4 31 20 dsDNA dsdna RB cord-333286-lr32e0w4 31 21 viruses virus NNS cord-333286-lr32e0w4 31 22 . . . cord-333286-lr32e0w4 32 1 The the DT cord-333286-lr32e0w4 32 2 genomic genomic JJ cord-333286-lr32e0w4 32 3 structures structure NNS cord-333286-lr32e0w4 32 4 are be VBP cord-333286-lr32e0w4 32 5 recognized recognize VBN cord-333286-lr32e0w4 32 6 by by IN cord-333286-lr32e0w4 32 7 different different JJ cord-333286-lr32e0w4 32 8 receptors receptor NNS cord-333286-lr32e0w4 32 9 in in IN cord-333286-lr32e0w4 32 10 the the DT cord-333286-lr32e0w4 32 11 host host NN cord-333286-lr32e0w4 32 12 and and CC cord-333286-lr32e0w4 32 13 activate activate VB cord-333286-lr32e0w4 32 14 different different JJ cord-333286-lr32e0w4 32 15 types type NNS cord-333286-lr32e0w4 32 16 of of IN cord-333286-lr32e0w4 32 17 immune immune JJ cord-333286-lr32e0w4 32 18 responses response NNS cord-333286-lr32e0w4 32 19 . . . cord-333286-lr32e0w4 33 1 Some some DT cord-333286-lr32e0w4 33 2 respiratory respiratory JJ cord-333286-lr32e0w4 33 3 viruses virus NNS cord-333286-lr32e0w4 33 4 , , , cord-333286-lr32e0w4 33 5 e.g. e.g. RB cord-333286-lr32e0w4 33 6 , , , cord-333286-lr32e0w4 33 7 coronaviruses coronaviruse NNS cord-333286-lr32e0w4 33 8 , , , cord-333286-lr32e0w4 33 9 are be VBP cord-333286-lr32e0w4 33 10 surrounded surround VBN cord-333286-lr32e0w4 33 11 by by IN cord-333286-lr32e0w4 33 12 a a DT cord-333286-lr32e0w4 33 13 viral viral JJ cord-333286-lr32e0w4 33 14 envelope envelope NN cord-333286-lr32e0w4 33 15 which which WDT cord-333286-lr32e0w4 33 16 confers confer VBZ cord-333286-lr32e0w4 33 17 additional additional JJ cord-333286-lr32e0w4 33 18 protection protection NN cord-333286-lr32e0w4 33 19 from from IN cord-333286-lr32e0w4 33 20 the the DT cord-333286-lr32e0w4 33 21 host host NN cord-333286-lr32e0w4 33 22 immune immune JJ cord-333286-lr32e0w4 33 23 system system NN cord-333286-lr32e0w4 33 24 . . . cord-333286-lr32e0w4 34 1 Respiratory respiratory JJ cord-333286-lr32e0w4 34 2 viruses virus NNS cord-333286-lr32e0w4 34 3 have have VBP cord-333286-lr32e0w4 34 4 further further RB cord-333286-lr32e0w4 34 5 developed develop VBN cord-333286-lr32e0w4 34 6 molecules molecule NNS cord-333286-lr32e0w4 34 7 that that WDT cord-333286-lr32e0w4 34 8 help help VBP cord-333286-lr32e0w4 34 9 in in IN cord-333286-lr32e0w4 34 10 evading evade VBG cord-333286-lr32e0w4 34 11 the the DT cord-333286-lr32e0w4 34 12 immune immune JJ cord-333286-lr32e0w4 34 13 response response NN cord-333286-lr32e0w4 34 14 , , , cord-333286-lr32e0w4 34 15 for for IN cord-333286-lr32e0w4 34 16 example example NN cord-333286-lr32e0w4 34 17 , , , cord-333286-lr32e0w4 34 18 by by IN cord-333286-lr32e0w4 34 19 disrupting disrupt VBG cord-333286-lr32e0w4 34 20 the the DT cord-333286-lr32e0w4 34 21 interferon interferon NN cord-333286-lr32e0w4 34 22 ( ( -LRB- cord-333286-lr32e0w4 34 23 IFN IFN NNP cord-333286-lr32e0w4 34 24 ) ) -RRB- cord-333286-lr32e0w4 34 25 response response NN cord-333286-lr32e0w4 34 26 and and CC cord-333286-lr32e0w4 34 27 hijacking hijack VBG cord-333286-lr32e0w4 34 28 the the DT cord-333286-lr32e0w4 34 29 host host NN cord-333286-lr32e0w4 34 30 's 's POS cord-333286-lr32e0w4 34 31 cellular cellular JJ cord-333286-lr32e0w4 34 32 machinery machinery NN cord-333286-lr32e0w4 34 33 for for IN cord-333286-lr32e0w4 34 34 the the DT cord-333286-lr32e0w4 34 35 production production NN cord-333286-lr32e0w4 34 36 of of IN cord-333286-lr32e0w4 34 37 virus virus NN cord-333286-lr32e0w4 34 38 copies copy NNS cord-333286-lr32e0w4 34 39 [ [ -LRB- cord-333286-lr32e0w4 34 40 15 15 CD cord-333286-lr32e0w4 34 41 ] ] -RRB- cord-333286-lr32e0w4 34 42 . . . cord-333286-lr32e0w4 35 1 Once once IN cord-333286-lr32e0w4 35 2 the the DT cord-333286-lr32e0w4 35 3 viruses virus NNS cord-333286-lr32e0w4 35 4 have have VBP cord-333286-lr32e0w4 35 5 penetrated penetrate VBN cord-333286-lr32e0w4 35 6 into into IN cord-333286-lr32e0w4 35 7 the the DT cord-333286-lr32e0w4 35 8 host host NN cord-333286-lr32e0w4 35 9 cells cell NNS cord-333286-lr32e0w4 35 10 , , , cord-333286-lr32e0w4 35 11 the the DT cord-333286-lr32e0w4 35 12 epithelial epithelial JJ cord-333286-lr32e0w4 35 13 and and CC cord-333286-lr32e0w4 35 14 immune immune JJ cord-333286-lr32e0w4 35 15 cells cell NNS cord-333286-lr32e0w4 35 16 detect detect VBP cord-333286-lr32e0w4 35 17 the the DT cord-333286-lr32e0w4 35 18 viral viral JJ cord-333286-lr32e0w4 35 19 structures structure NNS cord-333286-lr32e0w4 35 20 by by IN cord-333286-lr32e0w4 35 21 pattern pattern NN cord-333286-lr32e0w4 35 22 recognition recognition NN cord-333286-lr32e0w4 35 23 receptors receptor NNS cord-333286-lr32e0w4 35 24 ( ( -LRB- cord-333286-lr32e0w4 35 25 PRR PRR NNP cord-333286-lr32e0w4 35 26 ) ) -RRB- cord-333286-lr32e0w4 35 27 of of IN cord-333286-lr32e0w4 35 28 which which WDT cord-333286-lr32e0w4 35 29 Toll toll NN cord-333286-lr32e0w4 35 30 - - HYPH cord-333286-lr32e0w4 35 31 like like JJ cord-333286-lr32e0w4 35 32 receptors receptor NNS cord-333286-lr32e0w4 35 33 ( ( -LRB- cord-333286-lr32e0w4 35 34 TLRs TLRs NNP cord-333286-lr32e0w4 35 35 ) ) -RRB- cord-333286-lr32e0w4 35 36 and and CC cord-333286-lr32e0w4 35 37 retinoic retinoic JJ cord-333286-lr32e0w4 35 38 acid acid NN cord-333286-lr32e0w4 35 39 - - HYPH cord-333286-lr32e0w4 35 40 inducible inducible JJ cord-333286-lr32e0w4 35 41 gene gene NN cord-333286-lr32e0w4 35 42 I i NN cord-333286-lr32e0w4 35 43 ( ( -LRB- cord-333286-lr32e0w4 35 44 RIG RIG NNP cord-333286-lr32e0w4 35 45 - - HYPH cord-333286-lr32e0w4 35 46 I)-like I)-like NNP cord-333286-lr32e0w4 35 47 receptors receptor NNS cord-333286-lr32e0w4 35 48 ( ( -LRB- cord-333286-lr32e0w4 35 49 RLRs rlr NNS cord-333286-lr32e0w4 35 50 ) ) -RRB- cord-333286-lr32e0w4 35 51 play play VBP cord-333286-lr32e0w4 35 52 a a DT cord-333286-lr32e0w4 35 53 central central JJ cord-333286-lr32e0w4 35 54 role role NN cord-333286-lr32e0w4 35 55 . . . cord-333286-lr32e0w4 36 1 TLR3 TLR3 NNP cord-333286-lr32e0w4 36 2 , , , cord-333286-lr32e0w4 36 3 TLR7 TLR7 NNP cord-333286-lr32e0w4 36 4 , , , cord-333286-lr32e0w4 36 5 TLR8 TLR8 NNP cord-333286-lr32e0w4 36 6 , , , cord-333286-lr32e0w4 36 7 and and CC cord-333286-lr32e0w4 36 8 TLR9 TLR9 NNP cord-333286-lr32e0w4 36 9 are be VBP cord-333286-lr32e0w4 36 10 located locate VBN cord-333286-lr32e0w4 36 11 in in IN cord-333286-lr32e0w4 36 12 the the DT cord-333286-lr32e0w4 36 13 endosomes endosome NNS cord-333286-lr32e0w4 36 14 and and CC cord-333286-lr32e0w4 36 15 can can MD cord-333286-lr32e0w4 36 16 identify identify VB cord-333286-lr32e0w4 36 17 viral viral JJ cord-333286-lr32e0w4 36 18 ss ss NNP cord-333286-lr32e0w4 36 19 ( ( -LRB- cord-333286-lr32e0w4 36 20 TLR7 TLR7 NNP cord-333286-lr32e0w4 36 21 and and CC cord-333286-lr32e0w4 36 22 8) 8) NNP cord-333286-lr32e0w4 36 23 and and CC cord-333286-lr32e0w4 36 24 ds ds NNP cord-333286-lr32e0w4 36 25 ( ( -LRB- cord-333286-lr32e0w4 36 26 TLR3 TLR3 NNP cord-333286-lr32e0w4 36 27 ) ) -RRB- cord-333286-lr32e0w4 36 28 RNA RNA NNP cord-333286-lr32e0w4 36 29 structures structure NNS cord-333286-lr32e0w4 36 30 , , , cord-333286-lr32e0w4 36 31 and and CC cord-333286-lr32e0w4 36 32 DNA dna NN cord-333286-lr32e0w4 36 33 ( ( -LRB- cord-333286-lr32e0w4 36 34 TLR9 TLR9 NNP cord-333286-lr32e0w4 36 35 ) ) -RRB- cord-333286-lr32e0w4 36 36 [ [ -LRB- cord-333286-lr32e0w4 36 37 18 18 CD cord-333286-lr32e0w4 36 38 ] ] -RRB- cord-333286-lr32e0w4 36 39 . . . cord-333286-lr32e0w4 37 1 The the DT cord-333286-lr32e0w4 37 2 recognition recognition NN cord-333286-lr32e0w4 37 3 by by IN cord-333286-lr32e0w4 37 4 TLRs TLRs NNP cord-333286-lr32e0w4 37 5 leads lead VBZ cord-333286-lr32e0w4 37 6 to to IN cord-333286-lr32e0w4 37 7 activation activation NN cord-333286-lr32e0w4 37 8 of of IN cord-333286-lr32e0w4 37 9 transcription transcription NN cord-333286-lr32e0w4 37 10 factor factor NN cord-333286-lr32e0w4 37 11 nuclear nuclear JJ cord-333286-lr32e0w4 37 12 factor factor NN cord-333286-lr32e0w4 37 13 kappa kappa NN cord-333286-lr32e0w4 37 14 - - HYPH cord-333286-lr32e0w4 37 15 light light JJ cord-333286-lr32e0w4 37 16 - - HYPH cord-333286-lr32e0w4 37 17 chain chain NN cord-333286-lr32e0w4 37 18 - - HYPH cord-333286-lr32e0w4 37 19 enhancer enhancer NN cord-333286-lr32e0w4 37 20 of of IN cord-333286-lr32e0w4 37 21 activated activate VBN cord-333286-lr32e0w4 37 22 B b NN cord-333286-lr32e0w4 37 23 cells cell NNS cord-333286-lr32e0w4 37 24 ( ( -LRB- cord-333286-lr32e0w4 37 25 NF nf NN cord-333286-lr32e0w4 37 26 - - HYPH cord-333286-lr32e0w4 37 27 κB κB NNP cord-333286-lr32e0w4 37 28 ) ) -RRB- cord-333286-lr32e0w4 37 29 and and CC cord-333286-lr32e0w4 37 30 IFN IFN NNP cord-333286-lr32e0w4 37 31 regulatory regulatory JJ cord-333286-lr32e0w4 37 32 factors factor NNS cord-333286-lr32e0w4 37 33 ( ( -LRB- cord-333286-lr32e0w4 37 34 IRF IRF NNP cord-333286-lr32e0w4 37 35 ) ) -RRB- cord-333286-lr32e0w4 37 36 3 3 CD cord-333286-lr32e0w4 37 37 , , , cord-333286-lr32e0w4 37 38 5 5 CD cord-333286-lr32e0w4 37 39 , , , cord-333286-lr32e0w4 37 40 and and CC cord-333286-lr32e0w4 37 41 7 7 CD cord-333286-lr32e0w4 37 42 [ [ -LRB- cord-333286-lr32e0w4 37 43 12 12 CD cord-333286-lr32e0w4 37 44 , , , cord-333286-lr32e0w4 37 45 20 20 CD cord-333286-lr32e0w4 37 46 , , , cord-333286-lr32e0w4 37 47 21 21 CD cord-333286-lr32e0w4 37 48 ] ] -RRB- cord-333286-lr32e0w4 37 49 , , , cord-333286-lr32e0w4 37 50 resulting result VBG cord-333286-lr32e0w4 37 51 in in IN cord-333286-lr32e0w4 37 52 expression expression NN cord-333286-lr32e0w4 37 53 of of IN cord-333286-lr32e0w4 37 54 pro pro JJ cord-333286-lr32e0w4 37 55 - - JJ cord-333286-lr32e0w4 37 56 inflammatory inflammatory JJ cord-333286-lr32e0w4 37 57 cytokines cytokine NNS cord-333286-lr32e0w4 37 58 and and CC cord-333286-lr32e0w4 37 59 type type NN cord-333286-lr32e0w4 37 60 I -PRON- PRP cord-333286-lr32e0w4 37 61 IFNs ifns NN cord-333286-lr32e0w4 37 62 , , , cord-333286-lr32e0w4 37 63 IFN IFN NNP cord-333286-lr32e0w4 37 64 - - HYPH cord-333286-lr32e0w4 37 65 α α NNP cord-333286-lr32e0w4 37 66 and and CC cord-333286-lr32e0w4 37 67 IFN IFN NNP cord-333286-lr32e0w4 37 68 - - HYPH cord-333286-lr32e0w4 37 69 β β NNP cord-333286-lr32e0w4 37 70 . . . cord-333286-lr32e0w4 38 1 Type type NN cord-333286-lr32e0w4 38 2 I -PRON- PRP cord-333286-lr32e0w4 38 3 IFNs ifn NNS cord-333286-lr32e0w4 38 4 are be VBP cord-333286-lr32e0w4 38 5 broadly broadly RB cord-333286-lr32e0w4 38 6 secreted secrete VBN cord-333286-lr32e0w4 38 7 by by IN cord-333286-lr32e0w4 38 8 cells cell NNS cord-333286-lr32e0w4 38 9 , , , cord-333286-lr32e0w4 38 10 but but CC cord-333286-lr32e0w4 38 11 epithelial epithelial JJ cord-333286-lr32e0w4 38 12 cells cell NNS cord-333286-lr32e0w4 38 13 further far RBR cord-333286-lr32e0w4 38 14 secrete secrete JJ cord-333286-lr32e0w4 38 15 type type NN cord-333286-lr32e0w4 38 16 III iii CD cord-333286-lr32e0w4 38 17 lambda lambda NN cord-333286-lr32e0w4 38 18 IFNs ifn NNS cord-333286-lr32e0w4 38 19 in in IN cord-333286-lr32e0w4 38 20 response response NN cord-333286-lr32e0w4 38 21 to to IN cord-333286-lr32e0w4 38 22 viral viral JJ cord-333286-lr32e0w4 38 23 infections infection NNS cord-333286-lr32e0w4 38 24 . . . cord-333286-lr32e0w4 39 1 Cytoplasmic Cytoplasmic NNP cord-333286-lr32e0w4 39 2 RNAs rna NNS cord-333286-lr32e0w4 39 3 , , , cord-333286-lr32e0w4 39 4 on on IN cord-333286-lr32e0w4 39 5 the the DT cord-333286-lr32e0w4 39 6 other other JJ cord-333286-lr32e0w4 39 7 hand hand NN cord-333286-lr32e0w4 39 8 , , , cord-333286-lr32e0w4 39 9 are be VBP cord-333286-lr32e0w4 39 10 recognized recognize VBN cord-333286-lr32e0w4 39 11 by by IN cord-333286-lr32e0w4 39 12 RLRs rlr NNS cord-333286-lr32e0w4 39 13 , , , cord-333286-lr32e0w4 39 14 of of IN cord-333286-lr32e0w4 39 15 which which WDT cord-333286-lr32e0w4 39 16 RIG rig NN cord-333286-lr32e0w4 39 17 - - : cord-333286-lr32e0w4 39 18 I -PRON- PRP cord-333286-lr32e0w4 39 19 recognizes recognize VBZ cord-333286-lr32e0w4 39 20 ssRNA ssrna NN cord-333286-lr32e0w4 39 21 and and CC cord-333286-lr32e0w4 39 22 melanoma melanoma NN cord-333286-lr32e0w4 39 23 differentiation differentiation NN cord-333286-lr32e0w4 39 24 associated associate VBN cord-333286-lr32e0w4 40 1 5 5 LS cord-333286-lr32e0w4 40 2 ( ( -LRB- cord-333286-lr32e0w4 40 3 MDA-5 MDA-5 NNP cord-333286-lr32e0w4 40 4 ) ) -RRB- cord-333286-lr32e0w4 40 5 dsRNA dsrna NN cord-333286-lr32e0w4 40 6 . . . cord-333286-lr32e0w4 41 1 The the DT cord-333286-lr32e0w4 41 2 activation activation NN cord-333286-lr32e0w4 41 3 of of IN cord-333286-lr32e0w4 41 4 RLRs rlr NNS cord-333286-lr32e0w4 41 5 leads lead VBZ cord-333286-lr32e0w4 41 6 to to TO cord-333286-lr32e0w4 41 7 type type VB cord-333286-lr32e0w4 41 8 I -PRON- PRP cord-333286-lr32e0w4 41 9 ( ( -LRB- cord-333286-lr32e0w4 41 10 and and CC cord-333286-lr32e0w4 41 11 type type NN cord-333286-lr32e0w4 41 12 III iii CD cord-333286-lr32e0w4 41 13 in in IN cord-333286-lr32e0w4 41 14 epithelial epithelial JJ cord-333286-lr32e0w4 41 15 cells cell NNS cord-333286-lr32e0w4 41 16 ) ) -RRB- cord-333286-lr32e0w4 42 1 IFN IFN NNP cord-333286-lr32e0w4 42 2 production production NN cord-333286-lr32e0w4 42 3 via via IN cord-333286-lr32e0w4 42 4 mitochondrial mitochondrial JJ cord-333286-lr32e0w4 42 5 antiviral antiviral JJ cord-333286-lr32e0w4 42 6 signaling signal VBG cord-333286-lr32e0w4 42 7 protein protein NN cord-333286-lr32e0w4 42 8 ( ( -LRB- cord-333286-lr32e0w4 42 9 MAVS MAVS NNP cord-333286-lr32e0w4 42 10 ) ) -RRB- cord-333286-lr32e0w4 42 11 . . . cord-333286-lr32e0w4 43 1 Type type NN cord-333286-lr32e0w4 43 2 I I NNP cord-333286-lr32e0w4 43 3 and and CC cord-333286-lr32e0w4 43 4 III III NNP cord-333286-lr32e0w4 43 5 IFNs ifn NNS cord-333286-lr32e0w4 43 6 induce induce VBP cord-333286-lr32e0w4 43 7 an an DT cord-333286-lr32e0w4 43 8 antiviral antiviral JJ cord-333286-lr32e0w4 43 9 state state NN cord-333286-lr32e0w4 43 10 in in IN cord-333286-lr32e0w4 43 11 the the DT cord-333286-lr32e0w4 43 12 surrounding surround VBG cord-333286-lr32e0w4 43 13 cells cell NNS cord-333286-lr32e0w4 43 14 which which WDT cord-333286-lr32e0w4 43 15 is be VBZ cord-333286-lr32e0w4 43 16 not not RB cord-333286-lr32e0w4 43 17 , , , cord-333286-lr32e0w4 43 18 however however RB cord-333286-lr32e0w4 43 19 , , , cord-333286-lr32e0w4 43 20 necessarily necessarily RB cord-333286-lr32e0w4 43 21 sufficient sufficient JJ cord-333286-lr32e0w4 43 22 to to TO cord-333286-lr32e0w4 43 23 resist resist VB cord-333286-lr32e0w4 43 24 the the DT cord-333286-lr32e0w4 43 25 infection infection NN cord-333286-lr32e0w4 43 26 , , , cord-333286-lr32e0w4 43 27 but but CC cord-333286-lr32e0w4 43 28 delays delay VBZ cord-333286-lr32e0w4 43 29 the the DT cord-333286-lr32e0w4 43 30 spreading spreading NN cord-333286-lr32e0w4 43 31 of of IN cord-333286-lr32e0w4 43 32 the the DT cord-333286-lr32e0w4 43 33 infection infection NN cord-333286-lr32e0w4 43 34 [ [ -LRB- cord-333286-lr32e0w4 43 35 12 12 CD cord-333286-lr32e0w4 43 36 , , , cord-333286-lr32e0w4 43 37 22 22 CD cord-333286-lr32e0w4 43 38 ] ] -RRB- cord-333286-lr32e0w4 43 39 . . . cord-333286-lr32e0w4 44 1 The the DT cord-333286-lr32e0w4 44 2 activation activation NN cord-333286-lr32e0w4 44 3 of of IN cord-333286-lr32e0w4 44 4 RLRs rlr NNS cord-333286-lr32e0w4 44 5 , , , cord-333286-lr32e0w4 44 6 and and CC cord-333286-lr32e0w4 44 7 TLRs tlr NNS cord-333286-lr32e0w4 44 8 by by IN cord-333286-lr32e0w4 44 9 viral viral JJ cord-333286-lr32e0w4 44 10 infection infection NN cord-333286-lr32e0w4 44 11 and and CC cord-333286-lr32e0w4 44 12 cellular cellular JJ cord-333286-lr32e0w4 44 13 stress stress NN cord-333286-lr32e0w4 44 14 , , , cord-333286-lr32e0w4 44 15 leads lead VBZ cord-333286-lr32e0w4 44 16 to to IN cord-333286-lr32e0w4 44 17 formation formation NN cord-333286-lr32e0w4 44 18 of of IN cord-333286-lr32e0w4 44 19 nucleotide nucleotide RB cord-333286-lr32e0w4 44 20 - - HYPH cord-333286-lr32e0w4 44 21 binding bind VBG cord-333286-lr32e0w4 44 22 oligomerization oligomerization NN cord-333286-lr32e0w4 44 23 domain domain NN cord-333286-lr32e0w4 44 24 ( ( -LRB- cord-333286-lr32e0w4 44 25 NOD)- NOD)- NNP cord-333286-lr32e0w4 44 26 , , , cord-333286-lr32e0w4 44 27 leucine leucine NN cord-333286-lr32e0w4 44 28 - - HYPH cord-333286-lr32e0w4 44 29 rich rich JJ cord-333286-lr32e0w4 44 30 repeat repeat NN cord-333286-lr32e0w4 44 31 ( ( -LRB- cord-333286-lr32e0w4 44 32 LRR)- LRR)- NNP cord-333286-lr32e0w4 44 33 , , , cord-333286-lr32e0w4 44 34 and and CC cord-333286-lr32e0w4 44 35 pyrin pyrin NNP cord-333286-lr32e0w4 44 36 domain domain NN cord-333286-lr32e0w4 44 37 - - HYPH cord-333286-lr32e0w4 44 38 containing contain VBG cord-333286-lr32e0w4 44 39 protein protein NN cord-333286-lr32e0w4 44 40 3 3 CD cord-333286-lr32e0w4 45 1 ( ( -LRB- cord-333286-lr32e0w4 45 2 NLRP3 NLRP3 NNP cord-333286-lr32e0w4 45 3 ) ) -RRB- cord-333286-lr32e0w4 45 4 inflammasome inflammasome NNP cord-333286-lr32e0w4 45 5 [ [ -LRB- cord-333286-lr32e0w4 45 6 23 23 CD cord-333286-lr32e0w4 45 7 ] ] -RRB- cord-333286-lr32e0w4 45 8 . . . cord-333286-lr32e0w4 46 1 Although although IN cord-333286-lr32e0w4 46 2 the the DT cord-333286-lr32e0w4 46 3 role role NN cord-333286-lr32e0w4 46 4 of of IN cord-333286-lr32e0w4 46 5 NLRP3 nlrp3 NN cord-333286-lr32e0w4 46 6 is be VBZ cord-333286-lr32e0w4 46 7 still still RB cord-333286-lr32e0w4 46 8 somewhat somewhat RB cord-333286-lr32e0w4 46 9 unclear unclear JJ cord-333286-lr32e0w4 46 10 in in IN cord-333286-lr32e0w4 46 11 viral viral JJ cord-333286-lr32e0w4 46 12 RTIs rti NNS cord-333286-lr32e0w4 46 13 , , , cord-333286-lr32e0w4 46 14 it -PRON- PRP cord-333286-lr32e0w4 46 15 seems seem VBZ cord-333286-lr32e0w4 46 16 to to TO cord-333286-lr32e0w4 46 17 play play VB cord-333286-lr32e0w4 46 18 a a DT cord-333286-lr32e0w4 46 19 role role NN cord-333286-lr32e0w4 46 20 at at IN cord-333286-lr32e0w4 46 21 least least JJS cord-333286-lr32e0w4 46 22 in in IN cord-333286-lr32e0w4 46 23 rhinovirus rhinovirus NN cord-333286-lr32e0w4 46 24 , , , cord-333286-lr32e0w4 46 25 influenza influenza NN cord-333286-lr32e0w4 46 26 , , , cord-333286-lr32e0w4 46 27 adenovirus adenovirus NN cord-333286-lr32e0w4 46 28 , , , cord-333286-lr32e0w4 46 29 and and CC cord-333286-lr32e0w4 46 30 RSV RSV NNP cord-333286-lr32e0w4 46 31 infections infection NNS cord-333286-lr32e0w4 46 32 . . . cord-333286-lr32e0w4 47 1 NLRP3 NLRP3 NNP cord-333286-lr32e0w4 48 1 inflammasome inflammasome NNP cord-333286-lr32e0w4 48 2 activation activation NN cord-333286-lr32e0w4 48 3 drives drive NNS cord-333286-lr32e0w4 48 4 caspase caspase NNP cord-333286-lr32e0w4 49 1 1-dependent 1-dependent CD cord-333286-lr32e0w4 49 2 IL-1β il-1β NN cord-333286-lr32e0w4 49 3 and and CC cord-333286-lr32e0w4 49 4 IL-18 IL-18 NNP cord-333286-lr32e0w4 49 5 cytokine cytokine JJ cord-333286-lr32e0w4 49 6 response response NN cord-333286-lr32e0w4 49 7 and and CC cord-333286-lr32e0w4 49 8 inflammatory inflammatory JJ cord-333286-lr32e0w4 49 9 programmed program VBN cord-333286-lr32e0w4 49 10 cell cell NN cord-333286-lr32e0w4 49 11 death death NN cord-333286-lr32e0w4 49 12 ( ( -LRB- cord-333286-lr32e0w4 49 13 pyroptosis pyroptosis NNP cord-333286-lr32e0w4 49 14 ) ) -RRB- cord-333286-lr32e0w4 49 15 [ [ -LRB- cord-333286-lr32e0w4 49 16 24 24 CD cord-333286-lr32e0w4 49 17 ] ] -RRB- cord-333286-lr32e0w4 49 18 . . . cord-333286-lr32e0w4 50 1 Epithelium epithelium NN cord-333286-lr32e0w4 50 2 - - HYPH cord-333286-lr32e0w4 50 3 derived derive VBN cord-333286-lr32e0w4 50 4 pro pro JJ cord-333286-lr32e0w4 50 5 - - JJ cord-333286-lr32e0w4 50 6 inflammatory inflammatory JJ cord-333286-lr32e0w4 50 7 cytokines cytokine NNS cord-333286-lr32e0w4 50 8 tumor tumor NN cord-333286-lr32e0w4 50 9 necrosis necrosis NN cord-333286-lr32e0w4 50 10 factor factor NN cord-333286-lr32e0w4 50 11 ( ( -LRB- cord-333286-lr32e0w4 50 12 TNF)-α tnf)-α NN cord-333286-lr32e0w4 50 13 , , , cord-333286-lr32e0w4 50 14 interleukin interleukin FW cord-333286-lr32e0w4 50 15 ( ( -LRB- cord-333286-lr32e0w4 50 16 IL)-1β IL)-1β NNP cord-333286-lr32e0w4 50 17 , , , cord-333286-lr32e0w4 50 18 IL-6 IL-6 NNP cord-333286-lr32e0w4 50 19 , , , cord-333286-lr32e0w4 50 20 chemokine chemokine NN cord-333286-lr32e0w4 50 21 ( ( -LRB- cord-333286-lr32e0w4 50 22 C C NNP cord-333286-lr32e0w4 50 23 - - HYPH cord-333286-lr32e0w4 50 24 C C NNP cord-333286-lr32e0w4 50 25 motif motif NN cord-333286-lr32e0w4 50 26 ) ) -RRB- cord-333286-lr32e0w4 50 27 ligand ligand NN cord-333286-lr32e0w4 50 28 ( ( -LRB- cord-333286-lr32e0w4 50 29 CCL CCL NNP cord-333286-lr32e0w4 50 30 ) ) -RRB- cord-333286-lr32e0w4 50 31 2 2 CD cord-333286-lr32e0w4 50 32 , , , cord-333286-lr32e0w4 50 33 CCL5 CCL5 NNP cord-333286-lr32e0w4 50 34 , , , cord-333286-lr32e0w4 50 35 chemokine chemokine NN cord-333286-lr32e0w4 50 36 ( ( -LRB- cord-333286-lr32e0w4 50 37 C c NN cord-333286-lr32e0w4 50 38 - - HYPH cord-333286-lr32e0w4 50 39 X x NN cord-333286-lr32e0w4 50 40 - - HYPH cord-333286-lr32e0w4 50 41 C c NN cord-333286-lr32e0w4 50 42 motif motif NN cord-333286-lr32e0w4 50 43 ) ) -RRB- cord-333286-lr32e0w4 50 44 ligand ligand NN cord-333286-lr32e0w4 50 45 ( ( -LRB- cord-333286-lr32e0w4 50 46 CXCL)8 CXCL)8 NNP cord-333286-lr32e0w4 50 47 , , , cord-333286-lr32e0w4 50 48 and and CC cord-333286-lr32e0w4 50 49 CXCL10 CXCL10 NNP cord-333286-lr32e0w4 50 50 induce induce VB cord-333286-lr32e0w4 50 51 innate innate JJ cord-333286-lr32e0w4 50 52 cellular cellular JJ cord-333286-lr32e0w4 50 53 responses response NNS cord-333286-lr32e0w4 50 54 by by IN cord-333286-lr32e0w4 50 55 attracting attract VBG cord-333286-lr32e0w4 50 56 and and CC cord-333286-lr32e0w4 50 57 activating activate VBG cord-333286-lr32e0w4 50 58 Natural Natural NNP cord-333286-lr32e0w4 50 59 Killer Killer NNP cord-333286-lr32e0w4 50 60 ( ( -LRB- cord-333286-lr32e0w4 50 61 NK NK NNP cord-333286-lr32e0w4 50 62 ) ) -RRB- cord-333286-lr32e0w4 50 63 cells cell NNS cord-333286-lr32e0w4 50 64 , , , cord-333286-lr32e0w4 50 65 macrophages macrophage NNS cord-333286-lr32e0w4 50 66 , , , cord-333286-lr32e0w4 50 67 and and CC cord-333286-lr32e0w4 50 68 neutrophils neutrophil NNS cord-333286-lr32e0w4 50 69 that that IN cord-333286-lr32e0w4 50 70 further further RB cord-333286-lr32e0w4 50 71 amplify amplify VBP cord-333286-lr32e0w4 50 72 the the DT cord-333286-lr32e0w4 50 73 innate innate JJ cord-333286-lr32e0w4 50 74 cytokine cytokine NN cord-333286-lr32e0w4 50 75 and and CC cord-333286-lr32e0w4 50 76 chemokine chemokine NN cord-333286-lr32e0w4 50 77 response response NN cord-333286-lr32e0w4 50 78 [ [ -LRB- cord-333286-lr32e0w4 50 79 17 17 CD cord-333286-lr32e0w4 50 80 ] ] -RRB- cord-333286-lr32e0w4 50 81 . . . cord-333286-lr32e0w4 51 1 The the DT cord-333286-lr32e0w4 51 2 role role NN cord-333286-lr32e0w4 51 3 of of IN cord-333286-lr32e0w4 51 4 other other JJ cord-333286-lr32e0w4 51 5 innate innate JJ cord-333286-lr32e0w4 51 6 cells cell NNS cord-333286-lr32e0w4 51 7 like like IN cord-333286-lr32e0w4 51 8 , , , cord-333286-lr32e0w4 51 9 for for IN cord-333286-lr32e0w4 51 10 example example NN cord-333286-lr32e0w4 51 11 , , , cord-333286-lr32e0w4 51 12 intraepithelial intraepithelial JJ cord-333286-lr32e0w4 51 13 lymphocytes lymphocyte NNS cord-333286-lr32e0w4 51 14 , , , cord-333286-lr32e0w4 51 15 γδT γδt NN cord-333286-lr32e0w4 51 16 cells cell NNS cord-333286-lr32e0w4 51 17 , , , cord-333286-lr32e0w4 51 18 mucosa mucosa JJ cord-333286-lr32e0w4 51 19 associated associate VBD cord-333286-lr32e0w4 51 20 invariant invariant JJ cord-333286-lr32e0w4 51 21 T t NN cord-333286-lr32e0w4 51 22 cells cell NNS cord-333286-lr32e0w4 51 23 ( ( -LRB- cord-333286-lr32e0w4 51 24 MAIT MAIT NNP cord-333286-lr32e0w4 51 25 ) ) -RRB- cord-333286-lr32e0w4 51 26 , , , cord-333286-lr32e0w4 51 27 and and CC cord-333286-lr32e0w4 51 28 innate innate JJ cord-333286-lr32e0w4 51 29 lymphoid lymphoid JJ cord-333286-lr32e0w4 51 30 cells cell NNS cord-333286-lr32e0w4 51 31 ( ( -LRB- cord-333286-lr32e0w4 51 32 ILC ILC NNP cord-333286-lr32e0w4 51 33 ) ) -RRB- cord-333286-lr32e0w4 51 34 is be VBZ cord-333286-lr32e0w4 51 35 less less RBR cord-333286-lr32e0w4 51 36 well well RB cord-333286-lr32e0w4 51 37 described describe VBN cord-333286-lr32e0w4 51 38 in in IN cord-333286-lr32e0w4 51 39 viral viral JJ cord-333286-lr32e0w4 51 40 infections infection NNS cord-333286-lr32e0w4 51 41 , , , cord-333286-lr32e0w4 51 42 however however RB cord-333286-lr32e0w4 51 43 , , , cord-333286-lr32e0w4 51 44 they -PRON- PRP cord-333286-lr32e0w4 51 45 are be VBP cord-333286-lr32e0w4 51 46 likely likely JJ cord-333286-lr32e0w4 51 47 to to TO cord-333286-lr32e0w4 51 48 contribute contribute VB cord-333286-lr32e0w4 51 49 to to IN cord-333286-lr32e0w4 51 50 innate innate JJ cord-333286-lr32e0w4 51 51 and and CC cord-333286-lr32e0w4 51 52 adaptive adaptive JJ cord-333286-lr32e0w4 51 53 responses response NNS cord-333286-lr32e0w4 51 54 against against IN cord-333286-lr32e0w4 51 55 viral viral JJ cord-333286-lr32e0w4 51 56 infections infection NNS cord-333286-lr32e0w4 51 57 , , , cord-333286-lr32e0w4 51 58 as as IN cord-333286-lr32e0w4 51 59 exemplified exemplify VBN cord-333286-lr32e0w4 51 60 by by IN cord-333286-lr32e0w4 51 61 the the DT cord-333286-lr32e0w4 51 62 NK NK NNP cord-333286-lr32e0w4 51 63 cells cell NNS cord-333286-lr32e0w4 51 64 [ [ -LRB- cord-333286-lr32e0w4 51 65 25 25 CD cord-333286-lr32e0w4 51 66 , , , cord-333286-lr32e0w4 51 67 26 26 CD cord-333286-lr32e0w4 51 68 ] ] -RRB- cord-333286-lr32e0w4 51 69 and and CC cord-333286-lr32e0w4 51 70 by by IN cord-333286-lr32e0w4 51 71 the the DT cord-333286-lr32e0w4 51 72 role role NN cord-333286-lr32e0w4 51 73 of of IN cord-333286-lr32e0w4 51 74 ILC2 ILC2 NNP cord-333286-lr32e0w4 51 75 cells cell NNS cord-333286-lr32e0w4 51 76 in in IN cord-333286-lr32e0w4 51 77 overcoming overcome VBG cord-333286-lr32e0w4 51 78 an an DT cord-333286-lr32e0w4 51 79 influenza influenza NN cord-333286-lr32e0w4 51 80 infection infection NN cord-333286-lr32e0w4 51 81 [ [ -LRB- cord-333286-lr32e0w4 51 82 27 27 CD cord-333286-lr32e0w4 51 83 ] ] -RRB- cord-333286-lr32e0w4 51 84 . . . cord-333286-lr32e0w4 52 1 If if IN cord-333286-lr32e0w4 52 2 the the DT cord-333286-lr32e0w4 52 3 innate innate JJ cord-333286-lr32e0w4 52 4 immune immune JJ cord-333286-lr32e0w4 52 5 or or CC cord-333286-lr32e0w4 52 6 memory memory NN cord-333286-lr32e0w4 52 7 responses response NNS cord-333286-lr32e0w4 52 8 can can MD cord-333286-lr32e0w4 52 9 not not RB cord-333286-lr32e0w4 52 10 clear clear VB cord-333286-lr32e0w4 52 11 the the DT cord-333286-lr32e0w4 52 12 pathogen pathogen NN cord-333286-lr32e0w4 52 13 effectively effectively RB cord-333286-lr32e0w4 52 14 and and CC cord-333286-lr32e0w4 52 15 the the DT cord-333286-lr32e0w4 52 16 adaptive adaptive JJ cord-333286-lr32e0w4 52 17 immune immune JJ cord-333286-lr32e0w4 52 18 system system NN cord-333286-lr32e0w4 52 19 is be VBZ cord-333286-lr32e0w4 52 20 unexperienced unexperienced JJ cord-333286-lr32e0w4 52 21 with with IN cord-333286-lr32e0w4 52 22 the the DT cord-333286-lr32e0w4 52 23 virus virus NN cord-333286-lr32e0w4 52 24 , , , cord-333286-lr32e0w4 52 25 an an DT cord-333286-lr32e0w4 52 26 adaptive adaptive JJ cord-333286-lr32e0w4 52 27 immune immune JJ cord-333286-lr32e0w4 52 28 response response NN cord-333286-lr32e0w4 52 29 is be VBZ cord-333286-lr32e0w4 52 30 initiated initiate VBN cord-333286-lr32e0w4 52 31 and and CC cord-333286-lr32e0w4 52 32 required require VBN cord-333286-lr32e0w4 52 33 . . . cord-333286-lr32e0w4 53 1 Key key JJ cord-333286-lr32e0w4 53 2 are be VBP cord-333286-lr32e0w4 53 3 dendritic dendritic JJ cord-333286-lr32e0w4 53 4 cells cell NNS cord-333286-lr32e0w4 53 5 ( ( -LRB- cord-333286-lr32e0w4 53 6 DCs DCs NNP cord-333286-lr32e0w4 53 7 ) ) -RRB- cord-333286-lr32e0w4 53 8 that that WDT cord-333286-lr32e0w4 53 9 present present VBP cord-333286-lr32e0w4 53 10 the the DT cord-333286-lr32e0w4 53 11 viral viral JJ cord-333286-lr32e0w4 53 12 antigens antigen NNS cord-333286-lr32e0w4 53 13 and and CC cord-333286-lr32e0w4 53 14 induce induce VB cord-333286-lr32e0w4 53 15 B b NN cord-333286-lr32e0w4 53 16 and and CC cord-333286-lr32e0w4 53 17 T t NN cord-333286-lr32e0w4 53 18 cell cell NN cord-333286-lr32e0w4 53 19 responses response NNS cord-333286-lr32e0w4 53 20 against against IN cord-333286-lr32e0w4 53 21 the the DT cord-333286-lr32e0w4 53 22 pathogen pathogen NN cord-333286-lr32e0w4 53 23 in in IN cord-333286-lr32e0w4 53 24 the the DT cord-333286-lr32e0w4 53 25 secondary secondary JJ cord-333286-lr32e0w4 53 26 lymph lymph NN cord-333286-lr32e0w4 53 27 nodes node NNS cord-333286-lr32e0w4 53 28 . . . cord-333286-lr32e0w4 54 1 B B NNP cord-333286-lr32e0w4 54 2 and and CC cord-333286-lr32e0w4 54 3 T t NN cord-333286-lr32e0w4 54 4 cell cell NN cord-333286-lr32e0w4 54 5 responses response NNS cord-333286-lr32e0w4 54 6 initiate initiate VBP cord-333286-lr32e0w4 54 7 within within IN cord-333286-lr32e0w4 54 8 four four CD cord-333286-lr32e0w4 54 9 - - HYPH cord-333286-lr32e0w4 54 10 six six CD cord-333286-lr32e0w4 54 11 days day NNS cord-333286-lr32e0w4 54 12 post post NN cord-333286-lr32e0w4 54 13 - - NN cord-333286-lr32e0w4 54 14 infection infection NN cord-333286-lr32e0w4 54 15 and and CC cord-333286-lr32e0w4 54 16 peak peak NN cord-333286-lr32e0w4 54 17 later later RB cord-333286-lr32e0w4 54 18 at at IN cord-333286-lr32e0w4 54 19 days day NNS cord-333286-lr32e0w4 54 20 7 7 CD cord-333286-lr32e0w4 54 21 - - SYM cord-333286-lr32e0w4 54 22 14 14 CD cord-333286-lr32e0w4 54 23 depending depend VBG cord-333286-lr32e0w4 54 24 on on IN cord-333286-lr32e0w4 54 25 the the DT cord-333286-lr32e0w4 54 26 respiratory respiratory JJ cord-333286-lr32e0w4 54 27 virus virus NN cord-333286-lr32e0w4 54 28 [ [ -LRB- cord-333286-lr32e0w4 54 29 28 28 CD cord-333286-lr32e0w4 54 30 ] ] -RRB- cord-333286-lr32e0w4 54 31 [ [ -LRB- cord-333286-lr32e0w4 54 32 29 29 CD cord-333286-lr32e0w4 54 33 ] ] -RRB- cord-333286-lr32e0w4 54 34 [ [ -LRB- cord-333286-lr32e0w4 54 35 30 30 CD cord-333286-lr32e0w4 54 36 ] ] -RRB- cord-333286-lr32e0w4 54 37 . . . cord-333286-lr32e0w4 55 1 Typically typically RB cord-333286-lr32e0w4 55 2 , , , cord-333286-lr32e0w4 55 3 common common JJ cord-333286-lr32e0w4 55 4 respiratory respiratory JJ cord-333286-lr32e0w4 55 5 viruses virus NNS cord-333286-lr32e0w4 55 6 , , , cord-333286-lr32e0w4 55 7 such such JJ cord-333286-lr32e0w4 55 8 as as IN cord-333286-lr32e0w4 55 9 rhinovirus rhinovirus NN cord-333286-lr32e0w4 55 10 and and CC cord-333286-lr32e0w4 55 11 influenza influenza NN cord-333286-lr32e0w4 55 12 virus virus NN cord-333286-lr32e0w4 55 13 , , , cord-333286-lr32e0w4 55 14 are be VBP cord-333286-lr32e0w4 55 15 cleared clear VBN cord-333286-lr32e0w4 55 16 before before IN cord-333286-lr32e0w4 55 17 adaptive adaptive JJ cord-333286-lr32e0w4 55 18 immune immune JJ cord-333286-lr32e0w4 55 19 responses response NNS cord-333286-lr32e0w4 55 20 are be VBP cord-333286-lr32e0w4 55 21 activated activate VBN cord-333286-lr32e0w4 55 22 [ [ -LRB- cord-333286-lr32e0w4 55 23 22 22 CD cord-333286-lr32e0w4 55 24 , , , cord-333286-lr32e0w4 55 25 30 30 CD cord-333286-lr32e0w4 55 26 ] ] -RRB- cord-333286-lr32e0w4 55 27 indicating indicate VBG cord-333286-lr32e0w4 55 28 that that IN cord-333286-lr32e0w4 55 29 memory memory NN cord-333286-lr32e0w4 55 30 responses response NNS cord-333286-lr32e0w4 55 31 and and CC cord-333286-lr32e0w4 55 32 innate innate JJ cord-333286-lr32e0w4 55 33 immunity immunity NN cord-333286-lr32e0w4 55 34 are be VBP cord-333286-lr32e0w4 55 35 essential essential JJ cord-333286-lr32e0w4 55 36 in in IN cord-333286-lr32e0w4 55 37 viral viral JJ cord-333286-lr32e0w4 55 38 eradication eradication NN cord-333286-lr32e0w4 55 39 . . . cord-333286-lr32e0w4 56 1 However however RB cord-333286-lr32e0w4 56 2 , , , cord-333286-lr32e0w4 56 3 the the DT cord-333286-lr32e0w4 56 4 induction induction NN cord-333286-lr32e0w4 56 5 of of IN cord-333286-lr32e0w4 56 6 cytotoxic cytotoxic JJ cord-333286-lr32e0w4 56 7 CD8 CD8 NNP cord-333286-lr32e0w4 56 8 T T NNP cord-333286-lr32e0w4 56 9 cells cell NNS cord-333286-lr32e0w4 56 10 , , , cord-333286-lr32e0w4 56 11 CD4 CD4 NNP cord-333286-lr32e0w4 56 12 T T NNP cord-333286-lr32e0w4 56 13 cells cell NNS cord-333286-lr32e0w4 56 14 , , , cord-333286-lr32e0w4 56 15 and and CC cord-333286-lr32e0w4 56 16 antibody antibody NN cord-333286-lr32e0w4 56 17 responses response NNS cord-333286-lr32e0w4 56 18 is be VBZ cord-333286-lr32e0w4 56 19 key key JJ cord-333286-lr32e0w4 56 20 for for IN cord-333286-lr32e0w4 56 21 virus virus NN cord-333286-lr32e0w4 56 22 eradication eradication NN cord-333286-lr32e0w4 56 23 by by IN cord-333286-lr32e0w4 56 24 adaptive adaptive JJ cord-333286-lr32e0w4 56 25 immunity immunity NN cord-333286-lr32e0w4 56 26 and and CC cord-333286-lr32e0w4 56 27 for for IN cord-333286-lr32e0w4 56 28 establishing establish VBG cord-333286-lr32e0w4 56 29 protective protective JJ cord-333286-lr32e0w4 56 30 immunity immunity NN cord-333286-lr32e0w4 56 31 for for IN cord-333286-lr32e0w4 56 32 secondary secondary JJ cord-333286-lr32e0w4 56 33 infections infection NNS cord-333286-lr32e0w4 56 34 . . . cord-333286-lr32e0w4 57 1 The the DT cord-333286-lr32e0w4 57 2 activation activation NN cord-333286-lr32e0w4 57 3 of of IN cord-333286-lr32e0w4 57 4 the the DT cord-333286-lr32e0w4 57 5 epithelium epithelium NN cord-333286-lr32e0w4 57 6 , , , cord-333286-lr32e0w4 57 7 innate innate JJ cord-333286-lr32e0w4 57 8 immune immune JJ cord-333286-lr32e0w4 57 9 cells cell NNS cord-333286-lr32e0w4 57 10 , , , cord-333286-lr32e0w4 57 11 and and CC cord-333286-lr32e0w4 57 12 adaptive adaptive JJ cord-333286-lr32e0w4 57 13 responses response NNS cord-333286-lr32e0w4 57 14 is be VBZ cord-333286-lr32e0w4 57 15 important important JJ cord-333286-lr32e0w4 57 16 for for IN cord-333286-lr32e0w4 57 17 defense defense NN cord-333286-lr32e0w4 57 18 against against IN cord-333286-lr32e0w4 57 19 respiratory respiratory JJ cord-333286-lr32e0w4 57 20 viruses virus NNS cord-333286-lr32e0w4 57 21 , , , cord-333286-lr32e0w4 57 22 but but CC cord-333286-lr32e0w4 57 23 on on IN cord-333286-lr32e0w4 57 24 the the DT cord-333286-lr32e0w4 57 25 other other JJ cord-333286-lr32e0w4 57 26 hand hand NN cord-333286-lr32e0w4 57 27 , , , cord-333286-lr32e0w4 57 28 the the DT cord-333286-lr32e0w4 57 29 host host NN cord-333286-lr32e0w4 57 30 inflammatory inflammatory JJ cord-333286-lr32e0w4 57 31 response response NN cord-333286-lr32e0w4 57 32 is be VBZ cord-333286-lr32e0w4 57 33 the the DT cord-333286-lr32e0w4 57 34 major major JJ cord-333286-lr32e0w4 57 35 cause cause NN cord-333286-lr32e0w4 57 36 of of IN cord-333286-lr32e0w4 57 37 symptoms symptom NNS cord-333286-lr32e0w4 57 38 and and CC cord-333286-lr32e0w4 57 39 more more RBR cord-333286-lr32e0w4 57 40 severe severe JJ cord-333286-lr32e0w4 57 41 pathologies pathology NNS cord-333286-lr32e0w4 57 42 [ [ -LRB- cord-333286-lr32e0w4 57 43 12 12 CD cord-333286-lr32e0w4 57 44 , , , cord-333286-lr32e0w4 57 45 18 18 CD cord-333286-lr32e0w4 57 46 , , , cord-333286-lr32e0w4 57 47 31 31 CD cord-333286-lr32e0w4 57 48 ] ] -RRB- cord-333286-lr32e0w4 57 49 . . . cord-333286-lr32e0w4 58 1 Chronic chronic JJ cord-333286-lr32e0w4 58 2 activation activation NN cord-333286-lr32e0w4 58 3 of of IN cord-333286-lr32e0w4 58 4 CD8 CD8 NNP cord-333286-lr32e0w4 58 5 T T NNP cord-333286-lr32e0w4 58 6 cell cell NN cord-333286-lr32e0w4 58 7 responses response NNS cord-333286-lr32e0w4 58 8 and and CC cord-333286-lr32e0w4 58 9 adaptive adaptive JJ cord-333286-lr32e0w4 58 10 immunity immunity NN cord-333286-lr32e0w4 58 11 may may MD cord-333286-lr32e0w4 58 12 lead lead VB cord-333286-lr32e0w4 58 13 to to IN cord-333286-lr32e0w4 58 14 pulmonary pulmonary JJ cord-333286-lr32e0w4 58 15 damage damage NN cord-333286-lr32e0w4 58 16 and and CC cord-333286-lr32e0w4 58 17 acute acute JJ cord-333286-lr32e0w4 58 18 respiratory respiratory JJ cord-333286-lr32e0w4 58 19 distress distress NN cord-333286-lr32e0w4 58 20 syndrome syndrome NN cord-333286-lr32e0w4 58 21 , , , cord-333286-lr32e0w4 58 22 like like IN cord-333286-lr32e0w4 58 23 in in IN cord-333286-lr32e0w4 58 24 severe severe JJ cord-333286-lr32e0w4 58 25 cases case NNS cord-333286-lr32e0w4 58 26 of of IN cord-333286-lr32e0w4 58 27 coronavirus coronavirus NN cord-333286-lr32e0w4 58 28 infections infection NNS cord-333286-lr32e0w4 58 29 ( ( -LRB- cord-333286-lr32e0w4 58 30 e.g. e.g. RB cord-333286-lr32e0w4 58 31 , , , cord-333286-lr32e0w4 58 32 SARS SARS NNP cord-333286-lr32e0w4 58 33 - - HYPH cord-333286-lr32e0w4 58 34 CoV CoV NNP cord-333286-lr32e0w4 58 35 or or CC cord-333286-lr32e0w4 58 36 SARS SARS NNP cord-333286-lr32e0w4 58 37 CoV-2 CoV-2 NNP cord-333286-lr32e0w4 58 38 ) ) -RRB- cord-333286-lr32e0w4 58 39 and and CC cord-333286-lr32e0w4 58 40 pandemic pandemic NN cord-333286-lr32e0w4 58 41 influenza influenza NN cord-333286-lr32e0w4 58 42 virus virus NN cord-333286-lr32e0w4 58 43 infections infection NNS cord-333286-lr32e0w4 58 44 [ [ -LRB- cord-333286-lr32e0w4 58 45 18 18 CD cord-333286-lr32e0w4 58 46 , , , cord-333286-lr32e0w4 58 47 29 29 CD cord-333286-lr32e0w4 58 48 , , , cord-333286-lr32e0w4 58 49 32 32 CD cord-333286-lr32e0w4 58 50 ] ] -RRB- cord-333286-lr32e0w4 58 51 . . . cord-333286-lr32e0w4 59 1 In in IN cord-333286-lr32e0w4 59 2 milder mild JJR cord-333286-lr32e0w4 59 3 colds cold NNS cord-333286-lr32e0w4 59 4 , , , cord-333286-lr32e0w4 59 5 rhinoviruses rhinovirus NNS cord-333286-lr32e0w4 59 6 are be VBP cord-333286-lr32e0w4 59 7 not not RB cord-333286-lr32e0w4 59 8 cytolytic cytolytic JJ cord-333286-lr32e0w4 59 9 and and CC cord-333286-lr32e0w4 59 10 do do VBP cord-333286-lr32e0w4 59 11 not not RB cord-333286-lr32e0w4 59 12 actually actually RB cord-333286-lr32e0w4 59 13 cause cause VB cord-333286-lr32e0w4 59 14 considerable considerable JJ cord-333286-lr32e0w4 59 15 damage damage NN cord-333286-lr32e0w4 59 16 to to IN cord-333286-lr32e0w4 59 17 host host NN cord-333286-lr32e0w4 59 18 cells cell NNS cord-333286-lr32e0w4 59 19 and and CC cord-333286-lr32e0w4 59 20 may may MD cord-333286-lr32e0w4 59 21 pass pass VB cord-333286-lr32e0w4 59 22 asymptomatically asymptomatically RB cord-333286-lr32e0w4 59 23 . . . cord-333286-lr32e0w4 60 1 Presentation presentation NN cord-333286-lr32e0w4 60 2 of of IN cord-333286-lr32e0w4 60 3 cold cold JJ cord-333286-lr32e0w4 60 4 symptom symptom NN cord-333286-lr32e0w4 60 5 severity severity NN cord-333286-lr32e0w4 60 6 seems seem VBZ cord-333286-lr32e0w4 60 7 to to TO cord-333286-lr32e0w4 60 8 correlate correlate VB cord-333286-lr32e0w4 60 9 with with IN cord-333286-lr32e0w4 60 10 host host NN cord-333286-lr32e0w4 60 11 inflammatory inflammatory JJ cord-333286-lr32e0w4 60 12 response response NN cord-333286-lr32e0w4 60 13 . . . cord-333286-lr32e0w4 61 1 Specifically specifically RB cord-333286-lr32e0w4 61 2 , , , cord-333286-lr32e0w4 61 3 the the DT cord-333286-lr32e0w4 61 4 early early JJ cord-333286-lr32e0w4 61 5 expression expression NN cord-333286-lr32e0w4 61 6 of of IN cord-333286-lr32e0w4 61 7 pro pro JJ cord-333286-lr32e0w4 61 8 - - JJ cord-333286-lr32e0w4 61 9 inflammatory inflammatory JJ cord-333286-lr32e0w4 61 10 IL-8 il-8 NN cord-333286-lr32e0w4 61 11 [ [ -LRB- cord-333286-lr32e0w4 61 12 33 33 CD cord-333286-lr32e0w4 61 13 ] ] -RRB- cord-333286-lr32e0w4 61 14 and and CC cord-333286-lr32e0w4 61 15 high high JJ cord-333286-lr32e0w4 61 16 levels level NNS cord-333286-lr32e0w4 61 17 of of IN cord-333286-lr32e0w4 61 18 neutrophils neutrophil NNS cord-333286-lr32e0w4 61 19 in in IN cord-333286-lr32e0w4 61 20 nasal nasal NN cord-333286-lr32e0w4 61 21 aspirates aspirate NNS cord-333286-lr32e0w4 61 22 [ [ -LRB- cord-333286-lr32e0w4 61 23 34 34 CD cord-333286-lr32e0w4 61 24 ] ] -RRB- cord-333286-lr32e0w4 61 25 have have VBP cord-333286-lr32e0w4 61 26 been be VBN cord-333286-lr32e0w4 61 27 shown show VBN cord-333286-lr32e0w4 61 28 to to TO cord-333286-lr32e0w4 61 29 correlate correlate VB cord-333286-lr32e0w4 61 30 with with IN cord-333286-lr32e0w4 61 31 symptom symptom NN cord-333286-lr32e0w4 61 32 severity severity NN cord-333286-lr32e0w4 61 33 of of IN cord-333286-lr32e0w4 61 34 rhinovirus rhinovirus NN cord-333286-lr32e0w4 61 35 and and CC cord-333286-lr32e0w4 61 36 influenza influenza NN cord-333286-lr32e0w4 61 37 infection infection NN cord-333286-lr32e0w4 61 38 [ [ -LRB- cord-333286-lr32e0w4 61 39 35 35 CD cord-333286-lr32e0w4 61 40 , , , cord-333286-lr32e0w4 61 41 36 36 CD cord-333286-lr32e0w4 61 42 ] ] -RRB- cord-333286-lr32e0w4 61 43 . . . cord-333286-lr32e0w4 62 1 Production production NN cord-333286-lr32e0w4 62 2 of of IN cord-333286-lr32e0w4 62 3 anti anti JJ cord-333286-lr32e0w4 62 4 - - JJ cord-333286-lr32e0w4 62 5 inflammatory inflammatory JJ cord-333286-lr32e0w4 62 6 IL-10 IL-10 NNP cord-333286-lr32e0w4 62 7 , , , cord-333286-lr32e0w4 62 8 resolvins resolvins NNP cord-333286-lr32e0w4 62 9 , , , cord-333286-lr32e0w4 62 10 and and CC cord-333286-lr32e0w4 62 11 regulatory regulatory JJ cord-333286-lr32e0w4 62 12 T t NN cord-333286-lr32e0w4 62 13 cell cell NN cord-333286-lr32e0w4 62 14 responses response NNS cord-333286-lr32e0w4 62 15 acts act VBZ cord-333286-lr32e0w4 62 16 as as IN cord-333286-lr32e0w4 62 17 a a DT cord-333286-lr32e0w4 62 18 natural natural JJ cord-333286-lr32e0w4 62 19 mechanism mechanism NN cord-333286-lr32e0w4 62 20 to to TO cord-333286-lr32e0w4 62 21 control control VB cord-333286-lr32e0w4 62 22 lung lung NN cord-333286-lr32e0w4 62 23 inflammation inflammation NN cord-333286-lr32e0w4 62 24 during during IN cord-333286-lr32e0w4 62 25 acute acute JJ cord-333286-lr32e0w4 62 26 influenza influenza NN cord-333286-lr32e0w4 62 27 virus virus NN cord-333286-lr32e0w4 62 28 ( ( -LRB- cord-333286-lr32e0w4 62 29 and and CC cord-333286-lr32e0w4 62 30 others other NNS cord-333286-lr32e0w4 62 31 ) ) -RRB- cord-333286-lr32e0w4 62 32 infection infection NN cord-333286-lr32e0w4 62 33 [ [ -LRB- cord-333286-lr32e0w4 62 34 37 37 CD cord-333286-lr32e0w4 62 35 ] ] -RRB- cord-333286-lr32e0w4 62 36 [ [ -LRB- cord-333286-lr32e0w4 62 37 38 38 CD cord-333286-lr32e0w4 62 38 ] ] -RRB- cord-333286-lr32e0w4 62 39 [ [ -LRB- cord-333286-lr32e0w4 62 40 39 39 CD cord-333286-lr32e0w4 62 41 ] ] -RRB- cord-333286-lr32e0w4 62 42 . . . cord-333286-lr32e0w4 63 1 Virus virus NN cord-333286-lr32e0w4 63 2 - - HYPH cord-333286-lr32e0w4 63 3 host host NN cord-333286-lr32e0w4 63 4 immune immune JJ cord-333286-lr32e0w4 63 5 interactions interaction NNS cord-333286-lr32e0w4 63 6 are be VBP cord-333286-lr32e0w4 63 7 key key JJ cord-333286-lr32e0w4 63 8 to to IN cord-333286-lr32e0w4 63 9 viral viral JJ cord-333286-lr32e0w4 63 10 pathogenesis pathogenesis NN cord-333286-lr32e0w4 63 11 and and CC cord-333286-lr32e0w4 63 12 to to TO cord-333286-lr32e0w4 63 13 ultimately ultimately RB cord-333286-lr32e0w4 63 14 determine determine VB cord-333286-lr32e0w4 63 15 the the DT cord-333286-lr32e0w4 63 16 outcome outcome NN cord-333286-lr32e0w4 63 17 of of IN cord-333286-lr32e0w4 63 18 the the DT cord-333286-lr32e0w4 63 19 infection infection NN cord-333286-lr32e0w4 63 20 . . . cord-333286-lr32e0w4 64 1 Probiotics probiotic NNS cord-333286-lr32e0w4 64 2 , , , cord-333286-lr32e0w4 64 3 by by IN cord-333286-lr32e0w4 64 4 definition definition NN cord-333286-lr32e0w4 64 5 , , , cord-333286-lr32e0w4 64 6 are be VBP cord-333286-lr32e0w4 64 7 live live JJ cord-333286-lr32e0w4 64 8 microorganisms microorganism NNS cord-333286-lr32e0w4 64 9 that that WDT cord-333286-lr32e0w4 64 10 , , , cord-333286-lr32e0w4 64 11 when when WRB cord-333286-lr32e0w4 64 12 administered administer VBN cord-333286-lr32e0w4 64 13 in in IN cord-333286-lr32e0w4 64 14 adequate adequate JJ cord-333286-lr32e0w4 64 15 amounts amount NNS cord-333286-lr32e0w4 64 16 , , , cord-333286-lr32e0w4 64 17 confer confer VB cord-333286-lr32e0w4 64 18 a a DT cord-333286-lr32e0w4 64 19 health health NN cord-333286-lr32e0w4 64 20 benefit benefit NN cord-333286-lr32e0w4 64 21 on on IN cord-333286-lr32e0w4 64 22 the the DT cord-333286-lr32e0w4 64 23 host host NN cord-333286-lr32e0w4 64 24 [ [ -LRB- cord-333286-lr32e0w4 64 25 40 40 CD cord-333286-lr32e0w4 64 26 ] ] -RRB- cord-333286-lr32e0w4 64 27 . . . cord-333286-lr32e0w4 65 1 Most Most JJS cord-333286-lr32e0w4 65 2 probiotics probiotic NNS cord-333286-lr32e0w4 65 3 are be VBP cord-333286-lr32e0w4 65 4 lactic lactic JJ cord-333286-lr32e0w4 65 5 acid acid NN cord-333286-lr32e0w4 65 6 bacteria bacteria NNS cord-333286-lr32e0w4 65 7 , , , cord-333286-lr32e0w4 65 8 belonging belong VBG cord-333286-lr32e0w4 65 9 to to IN cord-333286-lr32e0w4 65 10 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 65 11 spp spp NNS cord-333286-lr32e0w4 65 12 . . . cord-333286-lr32e0w4 66 1 , , , cord-333286-lr32e0w4 66 2 ( ( -LRB- cord-333286-lr32e0w4 66 3 now now RB cord-333286-lr32e0w4 66 4 with with IN cord-333286-lr32e0w4 66 5 new new JJ cord-333286-lr32e0w4 66 6 taxonomy taxonomy NN cord-333286-lr32e0w4 66 7 including include VBG cord-333286-lr32e0w4 66 8 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 66 9 spp spp NNS cord-333286-lr32e0w4 66 10 . . . cord-333286-lr32e0w4 67 1 , , , cord-333286-lr32e0w4 67 2 Lactiplantibacillus Lactiplantibacillus NNP cord-333286-lr32e0w4 67 3 spp spp NNS cord-333286-lr32e0w4 67 4 . . . cord-333286-lr32e0w4 68 1 , , , cord-333286-lr32e0w4 68 2 Levilactobacillus Levilactobacillus NNP cord-333286-lr32e0w4 68 3 spp spp NNS cord-333286-lr32e0w4 68 4 . . . cord-333286-lr32e0w4 69 1 , , , cord-333286-lr32e0w4 69 2 Ligilactobacillus Ligilactobacillus NNP cord-333286-lr32e0w4 69 3 spp spp NNS cord-333286-lr32e0w4 69 4 . . . cord-333286-lr32e0w4 70 1 , , , cord-333286-lr32e0w4 70 2 Limosilactibacillus Limosilactibacillus NNP cord-333286-lr32e0w4 70 3 spp spp NNS cord-333286-lr32e0w4 70 4 . . . cord-333286-lr32e0w4 71 1 [ [ -LRB- cord-333286-lr32e0w4 71 2 41 41 CD cord-333286-lr32e0w4 71 3 ] ] -RRB- cord-333286-lr32e0w4 71 4 ) ) -RRB- cord-333286-lr32e0w4 71 5 or or CC cord-333286-lr32e0w4 71 6 Bifidobacterium bifidobacterium NN cord-333286-lr32e0w4 71 7 spp spp NNS cord-333286-lr32e0w4 71 8 . . . cord-333286-lr32e0w4 72 1 Furthermore furthermore RB cord-333286-lr32e0w4 72 2 , , , cord-333286-lr32e0w4 72 3 some some DT cord-333286-lr32e0w4 72 4 strains strain NNS cord-333286-lr32e0w4 72 5 of of IN cord-333286-lr32e0w4 72 6 other other JJ cord-333286-lr32e0w4 72 7 microbial microbial JJ cord-333286-lr32e0w4 72 8 genera genus NNS cord-333286-lr32e0w4 72 9 , , , cord-333286-lr32e0w4 72 10 such such JJ cord-333286-lr32e0w4 72 11 as as IN cord-333286-lr32e0w4 72 12 Propionibacterium Propionibacterium NNP cord-333286-lr32e0w4 72 13 spp spp NNS cord-333286-lr32e0w4 72 14 . . NNP cord-333286-lr32e0w4 72 15 , , , cord-333286-lr32e0w4 72 16 and and CC cord-333286-lr32e0w4 72 17 Bacillus Bacillus NNP cord-333286-lr32e0w4 72 18 spp spp NNS cord-333286-lr32e0w4 72 19 . . . cord-333286-lr32e0w4 72 20 , , , cord-333286-lr32e0w4 72 21 have have VBP cord-333286-lr32e0w4 72 22 been be VBN cord-333286-lr32e0w4 72 23 reported report VBN cord-333286-lr32e0w4 72 24 to to TO cord-333286-lr32e0w4 72 25 have have VB cord-333286-lr32e0w4 72 26 probiotic probiotic JJ cord-333286-lr32e0w4 72 27 properties property NNS cord-333286-lr32e0w4 72 28 . . . cord-333286-lr32e0w4 73 1 Traditional traditional JJ cord-333286-lr32e0w4 73 2 lactic lactic JJ cord-333286-lr32e0w4 73 3 acid acid NN cord-333286-lr32e0w4 73 4 bacteria bacteria NNS cord-333286-lr32e0w4 73 5 have have VBP cord-333286-lr32e0w4 73 6 long long RB cord-333286-lr32e0w4 73 7 been be VBN cord-333286-lr32e0w4 73 8 considered consider VBN cord-333286-lr32e0w4 73 9 safe safe JJ cord-333286-lr32e0w4 73 10 and and CC cord-333286-lr32e0w4 73 11 suitable suitable JJ cord-333286-lr32e0w4 73 12 for for IN cord-333286-lr32e0w4 73 13 human human JJ cord-333286-lr32e0w4 73 14 consumption consumption NN cord-333286-lr32e0w4 73 15 as as IN cord-333286-lr32e0w4 73 16 very very RB cord-333286-lr32e0w4 73 17 few few JJ cord-333286-lr32e0w4 73 18 instances instance NNS cord-333286-lr32e0w4 73 19 of of IN cord-333286-lr32e0w4 73 20 infection infection NN cord-333286-lr32e0w4 73 21 have have VBP cord-333286-lr32e0w4 73 22 been be VBN cord-333286-lr32e0w4 73 23 associated associate VBN cord-333286-lr32e0w4 73 24 with with IN cord-333286-lr32e0w4 73 25 these these DT cord-333286-lr32e0w4 73 26 bacteria bacteria NNS cord-333286-lr32e0w4 73 27 , , , cord-333286-lr32e0w4 73 28 and and CC cord-333286-lr32e0w4 73 29 several several JJ cord-333286-lr32e0w4 73 30 published publish VBN cord-333286-lr32e0w4 73 31 studies study NNS cord-333286-lr32e0w4 73 32 have have VBP cord-333286-lr32e0w4 73 33 specifically specifically RB cord-333286-lr32e0w4 73 34 addressed address VBN cord-333286-lr32e0w4 73 35 their -PRON- PRP$ cord-333286-lr32e0w4 73 36 safety safety NN cord-333286-lr32e0w4 73 37 ( ( -LRB- cord-333286-lr32e0w4 73 38 reviewed review VBN cord-333286-lr32e0w4 73 39 , , , cord-333286-lr32e0w4 73 40 e.g. e.g. RB cord-333286-lr32e0w4 73 41 , , , cord-333286-lr32e0w4 73 42 by by IN cord-333286-lr32e0w4 73 43 [ [ -LRB- cord-333286-lr32e0w4 73 44 42 42 CD cord-333286-lr32e0w4 73 45 ] ] -RRB- cord-333286-lr32e0w4 74 1 [ [ -LRB- cord-333286-lr32e0w4 74 2 43 43 CD cord-333286-lr32e0w4 74 3 ] ] -RRB- cord-333286-lr32e0w4 74 4 [ [ -LRB- cord-333286-lr32e0w4 74 5 44 44 CD cord-333286-lr32e0w4 74 6 ] ] -RRB- cord-333286-lr32e0w4 74 7 ) ) -RRB- cord-333286-lr32e0w4 74 8 . . . cord-333286-lr32e0w4 75 1 Regarding regard VBG cord-333286-lr32e0w4 75 2 probiotics probiotic NNS cord-333286-lr32e0w4 75 3 safety safety NN cord-333286-lr32e0w4 75 4 in in IN cord-333286-lr32e0w4 75 5 RTIs RTIs NNP cord-333286-lr32e0w4 75 6 , , , cord-333286-lr32e0w4 75 7 meta meta NNP cord-333286-lr32e0w4 75 8 - - HYPH cord-333286-lr32e0w4 75 9 analyses analysis NNS cord-333286-lr32e0w4 75 10 conclude conclude VBP cord-333286-lr32e0w4 75 11 that that IN cord-333286-lr32e0w4 75 12 the the DT cord-333286-lr32e0w4 75 13 reported report VBN cord-333286-lr32e0w4 75 14 side side NN cord-333286-lr32e0w4 75 15 effects effect NNS cord-333286-lr32e0w4 75 16 related relate VBN cord-333286-lr32e0w4 75 17 to to IN cord-333286-lr32e0w4 75 18 the the DT cord-333286-lr32e0w4 75 19 consumption consumption NN cord-333286-lr32e0w4 75 20 of of IN cord-333286-lr32e0w4 75 21 probiotics probiotic NNS cord-333286-lr32e0w4 75 22 were be VBD cord-333286-lr32e0w4 75 23 minor minor JJ cord-333286-lr32e0w4 75 24 [ [ -LRB- cord-333286-lr32e0w4 75 25 5 5 CD cord-333286-lr32e0w4 75 26 , , , cord-333286-lr32e0w4 75 27 6 6 CD cord-333286-lr32e0w4 75 28 , , , cord-333286-lr32e0w4 75 29 45 45 CD cord-333286-lr32e0w4 75 30 ] ] -RRB- cord-333286-lr32e0w4 75 31 . . . cord-333286-lr32e0w4 76 1 Probiotics probiotic NNS cord-333286-lr32e0w4 76 2 are be VBP cord-333286-lr32e0w4 76 3 mostly mostly RB cord-333286-lr32e0w4 76 4 consumed consume VBN cord-333286-lr32e0w4 76 5 orally orally RB cord-333286-lr32e0w4 76 6 in in IN cord-333286-lr32e0w4 76 7 the the DT cord-333286-lr32e0w4 76 8 form form NN cord-333286-lr32e0w4 76 9 of of IN cord-333286-lr32e0w4 76 10 dietary dietary JJ cord-333286-lr32e0w4 76 11 supplements supplement NNS cord-333286-lr32e0w4 76 12 and and CC cord-333286-lr32e0w4 76 13 food food NN cord-333286-lr32e0w4 76 14 ( ( -LRB- cord-333286-lr32e0w4 76 15 e.g. e.g. RB cord-333286-lr32e0w4 76 16 , , , cord-333286-lr32e0w4 76 17 yoghurt yoghurt NN cord-333286-lr32e0w4 76 18 ) ) -RRB- cord-333286-lr32e0w4 76 19 . . . cord-333286-lr32e0w4 77 1 Therefore therefore RB cord-333286-lr32e0w4 77 2 , , , cord-333286-lr32e0w4 77 3 their -PRON- PRP$ cord-333286-lr32e0w4 77 4 primary primary JJ cord-333286-lr32e0w4 77 5 site site NN cord-333286-lr32e0w4 77 6 of of IN cord-333286-lr32e0w4 77 7 action action NN cord-333286-lr32e0w4 77 8 is be VBZ cord-333286-lr32e0w4 77 9 in in IN cord-333286-lr32e0w4 77 10 the the DT cord-333286-lr32e0w4 77 11 gastrointestinal gastrointestinal JJ cord-333286-lr32e0w4 77 12 ( ( -LRB- cord-333286-lr32e0w4 77 13 GI GI NNP cord-333286-lr32e0w4 77 14 ) ) -RRB- cord-333286-lr32e0w4 77 15 tract tract NN cord-333286-lr32e0w4 77 16 [ [ -LRB- cord-333286-lr32e0w4 77 17 46 46 CD cord-333286-lr32e0w4 77 18 ] ] -RRB- cord-333286-lr32e0w4 77 19 . . . cord-333286-lr32e0w4 78 1 However however RB cord-333286-lr32e0w4 78 2 , , , cord-333286-lr32e0w4 78 3 probiotics probiotic NNS cord-333286-lr32e0w4 78 4 have have VBP cord-333286-lr32e0w4 78 5 been be VBN cord-333286-lr32e0w4 78 6 detected detect VBN cord-333286-lr32e0w4 78 7 with with IN cord-333286-lr32e0w4 78 8 PCR PCR NNP cord-333286-lr32e0w4 78 9 - - HYPH cord-333286-lr32e0w4 78 10 based base VBN cord-333286-lr32e0w4 78 11 methods method NNS cord-333286-lr32e0w4 78 12 from from IN cord-333286-lr32e0w4 78 13 nasopharyngeal nasopharyngeal JJ cord-333286-lr32e0w4 78 14 mucosa mucosa NN cord-333286-lr32e0w4 78 15 , , , cord-333286-lr32e0w4 78 16 adenoids adenoid NNS cord-333286-lr32e0w4 78 17 , , , cord-333286-lr32e0w4 78 18 and and CC cord-333286-lr32e0w4 78 19 tonsils tonsil NNS cord-333286-lr32e0w4 78 20 after after IN cord-333286-lr32e0w4 78 21 oral oral JJ cord-333286-lr32e0w4 78 22 consumption consumption NN cord-333286-lr32e0w4 78 23 [ [ -LRB- cord-333286-lr32e0w4 78 24 13 13 CD cord-333286-lr32e0w4 78 25 , , , cord-333286-lr32e0w4 78 26 47 47 CD cord-333286-lr32e0w4 78 27 , , , cord-333286-lr32e0w4 78 28 48 48 CD cord-333286-lr32e0w4 78 29 ] ] -RRB- cord-333286-lr32e0w4 78 30 , , , cord-333286-lr32e0w4 78 31 but but CC cord-333286-lr32e0w4 78 32 it -PRON- PRP cord-333286-lr32e0w4 78 33 is be VBZ cord-333286-lr32e0w4 78 34 unclear unclear JJ cord-333286-lr32e0w4 78 35 what what WP cord-333286-lr32e0w4 78 36 the the DT cord-333286-lr32e0w4 78 37 contribution contribution NN cord-333286-lr32e0w4 78 38 to to IN cord-333286-lr32e0w4 78 39 upper upper JJ cord-333286-lr32e0w4 78 40 respiratory respiratory JJ cord-333286-lr32e0w4 78 41 tract tract NN cord-333286-lr32e0w4 78 42 immune immune JJ cord-333286-lr32e0w4 78 43 stimulation stimulation NN cord-333286-lr32e0w4 78 44 against against IN cord-333286-lr32e0w4 78 45 viral viral JJ cord-333286-lr32e0w4 78 46 RTI RTI NNP cord-333286-lr32e0w4 78 47 by by IN cord-333286-lr32e0w4 78 48 probiotics probiotic NNS cord-333286-lr32e0w4 78 49 is be VBZ cord-333286-lr32e0w4 78 50 , , , cord-333286-lr32e0w4 78 51 as as IN cord-333286-lr32e0w4 78 52 oral oral JJ cord-333286-lr32e0w4 78 53 ingestion ingestion NN cord-333286-lr32e0w4 78 54 results result NNS cord-333286-lr32e0w4 78 55 in in IN cord-333286-lr32e0w4 78 56 the the DT cord-333286-lr32e0w4 78 57 stimulation stimulation NN cord-333286-lr32e0w4 78 58 of of IN cord-333286-lr32e0w4 78 59 the the DT cord-333286-lr32e0w4 78 60 intestinal intestinal JJ cord-333286-lr32e0w4 78 61 immune immune JJ cord-333286-lr32e0w4 78 62 system system NN cord-333286-lr32e0w4 78 63 as as RB cord-333286-lr32e0w4 78 64 well well RB cord-333286-lr32e0w4 78 65 . . . cord-333286-lr32e0w4 79 1 The the DT cord-333286-lr32e0w4 79 2 small small JJ cord-333286-lr32e0w4 79 3 intestine intestine NN cord-333286-lr32e0w4 79 4 , , , cord-333286-lr32e0w4 79 5 that that DT cord-333286-lr32e0w4 79 6 is be VBZ cord-333286-lr32e0w4 79 7 naturally naturally RB cord-333286-lr32e0w4 79 8 exposed expose VBN cord-333286-lr32e0w4 79 9 to to IN cord-333286-lr32e0w4 79 10 microbes microbe NNS cord-333286-lr32e0w4 79 11 and and CC cord-333286-lr32e0w4 79 12 nutrients nutrient NNS cord-333286-lr32e0w4 79 13 due due JJ cord-333286-lr32e0w4 79 14 to to IN cord-333286-lr32e0w4 79 15 the the DT cord-333286-lr32e0w4 79 16 thin thin JJ cord-333286-lr32e0w4 79 17 mucosal mucosal JJ cord-333286-lr32e0w4 79 18 layer layer NN cord-333286-lr32e0w4 79 19 , , , cord-333286-lr32e0w4 79 20 seems seem VBZ cord-333286-lr32e0w4 79 21 to to TO cord-333286-lr32e0w4 79 22 play play VB cord-333286-lr32e0w4 79 23 an an DT cord-333286-lr32e0w4 79 24 important important JJ cord-333286-lr32e0w4 79 25 role role NN cord-333286-lr32e0w4 79 26 in in IN cord-333286-lr32e0w4 79 27 immune immune JJ cord-333286-lr32e0w4 79 28 stimulation stimulation NN cord-333286-lr32e0w4 79 29 by by IN cord-333286-lr32e0w4 79 30 probiotics probiotic NNS cord-333286-lr32e0w4 79 31 [ [ -LRB- cord-333286-lr32e0w4 79 32 49 49 CD cord-333286-lr32e0w4 79 33 , , , cord-333286-lr32e0w4 79 34 50 50 CD cord-333286-lr32e0w4 79 35 ] ] -RRB- cord-333286-lr32e0w4 79 36 . . . cord-333286-lr32e0w4 80 1 However however RB cord-333286-lr32e0w4 80 2 , , , cord-333286-lr32e0w4 80 3 dissecting dissect VBG cord-333286-lr32e0w4 80 4 the the DT cord-333286-lr32e0w4 80 5 relative relative JJ cord-333286-lr32e0w4 80 6 contributions contribution NNS cord-333286-lr32e0w4 80 7 of of IN cord-333286-lr32e0w4 80 8 the the DT cord-333286-lr32e0w4 80 9 small small JJ cord-333286-lr32e0w4 80 10 and and CC cord-333286-lr32e0w4 80 11 large large JJ cord-333286-lr32e0w4 80 12 intestine intestine NN cord-333286-lr32e0w4 80 13 and and CC cord-333286-lr32e0w4 80 14 upper upper JJ cord-333286-lr32e0w4 80 15 GI GI NNP cord-333286-lr32e0w4 80 16 tract tract NN cord-333286-lr32e0w4 80 17 on on IN cord-333286-lr32e0w4 80 18 immune immune JJ cord-333286-lr32e0w4 80 19 stimulation stimulation NN cord-333286-lr32e0w4 80 20 against against IN cord-333286-lr32e0w4 80 21 RTI RTI NNP cord-333286-lr32e0w4 80 22 is be VBZ cord-333286-lr32e0w4 80 23 challenging challenge VBG cord-333286-lr32e0w4 80 24 with with IN cord-333286-lr32e0w4 80 25 available available JJ cord-333286-lr32e0w4 80 26 research research NN cord-333286-lr32e0w4 80 27 data datum NNS cord-333286-lr32e0w4 80 28 . . . cord-333286-lr32e0w4 81 1 Independent independent JJ cord-333286-lr32e0w4 81 2 of of IN cord-333286-lr32e0w4 81 3 the the DT cord-333286-lr32e0w4 81 4 actual actual JJ cord-333286-lr32e0w4 81 5 mucosal mucosal JJ cord-333286-lr32e0w4 81 6 inductor inductor NN cord-333286-lr32e0w4 81 7 site site NN cord-333286-lr32e0w4 81 8 of of IN cord-333286-lr32e0w4 81 9 the the DT cord-333286-lr32e0w4 81 10 probiotic probiotic NN cord-333286-lr32e0w4 81 11 , , , cord-333286-lr32e0w4 81 12 it -PRON- PRP cord-333286-lr32e0w4 81 13 has have VBZ cord-333286-lr32e0w4 81 14 been be VBN cord-333286-lr32e0w4 81 15 shown show VBN cord-333286-lr32e0w4 81 16 that that IN cord-333286-lr32e0w4 81 17 lymphocytes lymphocyte NNS cord-333286-lr32e0w4 81 18 circulate circulate VBP cord-333286-lr32e0w4 81 19 between between IN cord-333286-lr32e0w4 81 20 mucosal mucosal JJ cord-333286-lr32e0w4 81 21 tissues tissue NNS cord-333286-lr32e0w4 81 22 [ [ -LRB- cord-333286-lr32e0w4 81 23 51 51 CD cord-333286-lr32e0w4 81 24 ] ] -RRB- cord-333286-lr32e0w4 81 25 . . . cord-333286-lr32e0w4 82 1 Thus thus RB cord-333286-lr32e0w4 82 2 , , , cord-333286-lr32e0w4 82 3 local local JJ cord-333286-lr32e0w4 82 4 mucosal mucosal JJ cord-333286-lr32e0w4 82 5 stimulatory stimulatory JJ cord-333286-lr32e0w4 82 6 effects effect NNS cord-333286-lr32e0w4 82 7 may may MD cord-333286-lr32e0w4 82 8 influence influence VB cord-333286-lr32e0w4 82 9 immune immune JJ cord-333286-lr32e0w4 82 10 responses response NNS cord-333286-lr32e0w4 82 11 at at IN cord-333286-lr32e0w4 82 12 other other JJ cord-333286-lr32e0w4 82 13 mucosal mucosal JJ cord-333286-lr32e0w4 82 14 tissues tissue NNS cord-333286-lr32e0w4 82 15 and and CC cord-333286-lr32e0w4 82 16 contribute contribute VB cord-333286-lr32e0w4 82 17 to to IN cord-333286-lr32e0w4 82 18 antiviral antiviral JJ cord-333286-lr32e0w4 82 19 immunity immunity NN cord-333286-lr32e0w4 82 20 . . . cord-333286-lr32e0w4 83 1 Even even RB cord-333286-lr32e0w4 83 2 very very RB cord-333286-lr32e0w4 83 3 closely closely RB cord-333286-lr32e0w4 83 4 related related JJ cord-333286-lr32e0w4 83 5 bacteria bacteria NNS cord-333286-lr32e0w4 83 6 have have VBP cord-333286-lr32e0w4 83 7 differences difference NNS cord-333286-lr32e0w4 83 8 in in IN cord-333286-lr32e0w4 83 9 their -PRON- PRP$ cord-333286-lr32e0w4 83 10 antigenic antigenic JJ cord-333286-lr32e0w4 83 11 structures structure NNS cord-333286-lr32e0w4 83 12 and and CC cord-333286-lr32e0w4 83 13 thus thus RB cord-333286-lr32e0w4 83 14 influence influence VB cord-333286-lr32e0w4 83 15 the the DT cord-333286-lr32e0w4 83 16 immune immune JJ cord-333286-lr32e0w4 83 17 system system NN cord-333286-lr32e0w4 83 18 uniquely uniquely RB cord-333286-lr32e0w4 83 19 . . . cord-333286-lr32e0w4 84 1 Probiotics probiotic NNS cord-333286-lr32e0w4 84 2 are be VBP cord-333286-lr32e0w4 84 3 thought think VBN cord-333286-lr32e0w4 84 4 to to TO cord-333286-lr32e0w4 84 5 influence influence VB cord-333286-lr32e0w4 84 6 immune immune JJ cord-333286-lr32e0w4 84 7 function function NN cord-333286-lr32e0w4 84 8 primarily primarily RB cord-333286-lr32e0w4 84 9 in in IN cord-333286-lr32e0w4 84 10 a a DT cord-333286-lr32e0w4 84 11 strain strain NN cord-333286-lr32e0w4 84 12 - - HYPH cord-333286-lr32e0w4 84 13 specific specific JJ cord-333286-lr32e0w4 84 14 manner manner NN cord-333286-lr32e0w4 84 15 [ [ -LRB- cord-333286-lr32e0w4 84 16 40 40 CD cord-333286-lr32e0w4 84 17 ] ] -RRB- cord-333286-lr32e0w4 84 18 . . . cord-333286-lr32e0w4 85 1 Although although IN cord-333286-lr32e0w4 85 2 these these DT cord-333286-lr32e0w4 85 3 effects effect NNS cord-333286-lr32e0w4 85 4 in in IN cord-333286-lr32e0w4 85 5 general general JJ cord-333286-lr32e0w4 85 6 are be VBP cord-333286-lr32e0w4 85 7 strain strain NN cord-333286-lr32e0w4 85 8 - - HYPH cord-333286-lr32e0w4 85 9 specific specific JJ cord-333286-lr32e0w4 85 10 , , , cord-333286-lr32e0w4 85 11 probiotics probiotic NNS cord-333286-lr32e0w4 85 12 also also RB cord-333286-lr32e0w4 85 13 share share VBP cord-333286-lr32e0w4 85 14 common common JJ cord-333286-lr32e0w4 85 15 mechanisms mechanism NNS cord-333286-lr32e0w4 85 16 of of IN cord-333286-lr32e0w4 85 17 immune immune JJ cord-333286-lr32e0w4 85 18 stimulation stimulation NN cord-333286-lr32e0w4 85 19 , , , cord-333286-lr32e0w4 85 20 such such JJ cord-333286-lr32e0w4 85 21 as as IN cord-333286-lr32e0w4 85 22 the the DT cord-333286-lr32e0w4 85 23 secretion secretion NN cord-333286-lr32e0w4 85 24 of of IN cord-333286-lr32e0w4 85 25 metabolites metabolite NNS cord-333286-lr32e0w4 85 26 . . . cord-333286-lr32e0w4 86 1 For for IN cord-333286-lr32e0w4 86 2 instance instance NN cord-333286-lr32e0w4 86 3 , , , cord-333286-lr32e0w4 86 4 short short JJ cord-333286-lr32e0w4 86 5 chain chain NN cord-333286-lr32e0w4 86 6 fatty fatty JJ cord-333286-lr32e0w4 86 7 acids acid NNS cord-333286-lr32e0w4 86 8 are be VBP cord-333286-lr32e0w4 86 9 known know VBN cord-333286-lr32e0w4 86 10 to to TO cord-333286-lr32e0w4 86 11 have have VB cord-333286-lr32e0w4 86 12 immunomodulatory immunomodulatory JJ cord-333286-lr32e0w4 86 13 effects effect NNS cord-333286-lr32e0w4 86 14 [ [ -LRB- cord-333286-lr32e0w4 86 15 52 52 CD cord-333286-lr32e0w4 86 16 ] ] -RRB- cord-333286-lr32e0w4 86 17 . . . cord-333286-lr32e0w4 87 1 Direct direct JJ cord-333286-lr32e0w4 87 2 effects effect NNS cord-333286-lr32e0w4 87 3 of of IN cord-333286-lr32e0w4 87 4 the the DT cord-333286-lr32e0w4 87 5 probiotics probiotic NNS cord-333286-lr32e0w4 87 6 on on IN cord-333286-lr32e0w4 87 7 immune immune JJ cord-333286-lr32e0w4 87 8 function function NN cord-333286-lr32e0w4 87 9 are be VBP cord-333286-lr32e0w4 87 10 driven drive VBN cord-333286-lr32e0w4 87 11 by by IN cord-333286-lr32e0w4 87 12 interactions interaction NNS cord-333286-lr32e0w4 87 13 of of IN cord-333286-lr32e0w4 87 14 bacterial bacterial JJ cord-333286-lr32e0w4 87 15 structures structure NNS cord-333286-lr32e0w4 87 16 or or CC cord-333286-lr32e0w4 87 17 metabolites metabolite NNS cord-333286-lr32e0w4 87 18 with with IN cord-333286-lr32e0w4 87 19 receptors receptor NNS cord-333286-lr32e0w4 87 20 , , , cord-333286-lr32e0w4 87 21 like like IN cord-333286-lr32e0w4 87 22 TLRs TLRs NNP cord-333286-lr32e0w4 87 23 , , , cord-333286-lr32e0w4 87 24 on on IN cord-333286-lr32e0w4 87 25 the the DT cord-333286-lr32e0w4 87 26 host host NN cord-333286-lr32e0w4 87 27 epithelial epithelial JJ cord-333286-lr32e0w4 87 28 and and CC cord-333286-lr32e0w4 87 29 immune immune JJ cord-333286-lr32e0w4 87 30 cells cell NNS cord-333286-lr32e0w4 87 31 . . . cord-333286-lr32e0w4 88 1 On on IN cord-333286-lr32e0w4 88 2 the the DT cord-333286-lr32e0w4 88 3 other other JJ cord-333286-lr32e0w4 88 4 hand hand NN cord-333286-lr32e0w4 88 5 , , , cord-333286-lr32e0w4 88 6 probiotics probiotic NNS cord-333286-lr32e0w4 88 7 may may MD cord-333286-lr32e0w4 88 8 influence influence VB cord-333286-lr32e0w4 88 9 immune immune JJ cord-333286-lr32e0w4 88 10 function function NN cord-333286-lr32e0w4 88 11 indirectly indirectly RB cord-333286-lr32e0w4 88 12 by by IN cord-333286-lr32e0w4 88 13 changing change VBG cord-333286-lr32e0w4 88 14 the the DT cord-333286-lr32e0w4 88 15 composition composition NN cord-333286-lr32e0w4 88 16 and/or and/or CC cord-333286-lr32e0w4 88 17 activity activity NN cord-333286-lr32e0w4 88 18 of of IN cord-333286-lr32e0w4 88 19 the the DT cord-333286-lr32e0w4 88 20 host host NN cord-333286-lr32e0w4 88 21 microbiota microbiota NN cord-333286-lr32e0w4 88 22 [ [ -LRB- cord-333286-lr32e0w4 88 23 53 53 CD cord-333286-lr32e0w4 88 24 ] ] -RRB- cord-333286-lr32e0w4 88 25 . . . cord-333286-lr32e0w4 89 1 For for IN cord-333286-lr32e0w4 89 2 example example NN cord-333286-lr32e0w4 89 3 , , , cord-333286-lr32e0w4 89 4 in in IN cord-333286-lr32e0w4 89 5 the the DT cord-333286-lr32e0w4 89 6 small small JJ cord-333286-lr32e0w4 89 7 intestine intestine NN cord-333286-lr32e0w4 89 8 where where WRB cord-333286-lr32e0w4 89 9 the the DT cord-333286-lr32e0w4 89 10 number number NN cord-333286-lr32e0w4 89 11 of of IN cord-333286-lr32e0w4 89 12 endogenous endogenous JJ cord-333286-lr32e0w4 89 13 bacteria bacteria NNS cord-333286-lr32e0w4 89 14 is be VBZ cord-333286-lr32e0w4 89 15 lower low JJR cord-333286-lr32e0w4 89 16 than than IN cord-333286-lr32e0w4 89 17 in in IN cord-333286-lr32e0w4 89 18 the the DT cord-333286-lr32e0w4 89 19 large large JJ cord-333286-lr32e0w4 89 20 intestine intestine NN cord-333286-lr32e0w4 89 21 , , , cord-333286-lr32e0w4 89 22 ingestion ingestion NN cord-333286-lr32e0w4 89 23 of of IN cord-333286-lr32e0w4 89 24 probiotics probiotic NNS cord-333286-lr32e0w4 89 25 temporally temporally RB cord-333286-lr32e0w4 89 26 changes change VBZ cord-333286-lr32e0w4 89 27 the the DT cord-333286-lr32e0w4 89 28 microbiota microbiota NN cord-333286-lr32e0w4 89 29 composition composition NN cord-333286-lr32e0w4 89 30 and and CC cord-333286-lr32e0w4 89 31 influences influence VBZ cord-333286-lr32e0w4 89 32 the the DT cord-333286-lr32e0w4 89 33 host host NN cord-333286-lr32e0w4 89 34 immune immune JJ cord-333286-lr32e0w4 89 35 response response NN cord-333286-lr32e0w4 89 36 [ [ -LRB- cord-333286-lr32e0w4 89 37 49 49 CD cord-333286-lr32e0w4 89 38 , , , cord-333286-lr32e0w4 89 39 50 50 CD cord-333286-lr32e0w4 89 40 ] ] -RRB- cord-333286-lr32e0w4 89 41 . . . cord-333286-lr32e0w4 90 1 In in IN cord-333286-lr32e0w4 90 2 RTIs rti NNS cord-333286-lr32e0w4 90 3 , , , cord-333286-lr32e0w4 90 4 orally orally RB cord-333286-lr32e0w4 90 5 consumed consume VBD cord-333286-lr32e0w4 90 6 probiotics probiotic NNS cord-333286-lr32e0w4 90 7 may may MD cord-333286-lr32e0w4 90 8 elicit elicit VB cord-333286-lr32e0w4 90 9 systemic systemic JJ cord-333286-lr32e0w4 90 10 effects effect NNS cord-333286-lr32e0w4 90 11 from from IN cord-333286-lr32e0w4 90 12 the the DT cord-333286-lr32e0w4 90 13 GI GI NNP cord-333286-lr32e0w4 90 14 tract tract NN cord-333286-lr32e0w4 90 15 via via IN cord-333286-lr32e0w4 90 16 the the DT cord-333286-lr32e0w4 90 17 " " `` cord-333286-lr32e0w4 90 18 gut gut NN cord-333286-lr32e0w4 90 19 - - HYPH cord-333286-lr32e0w4 90 20 lung lung NN cord-333286-lr32e0w4 90 21 axis axis NN cord-333286-lr32e0w4 90 22 " " '' cord-333286-lr32e0w4 90 23 by by IN cord-333286-lr32e0w4 90 24 modulating modulate VBG cord-333286-lr32e0w4 90 25 mucosal mucosal JJ cord-333286-lr32e0w4 90 26 immune immune JJ cord-333286-lr32e0w4 90 27 function function NN cord-333286-lr32e0w4 90 28 [ [ -LRB- cord-333286-lr32e0w4 90 29 54 54 CD cord-333286-lr32e0w4 90 30 , , , cord-333286-lr32e0w4 90 31 55 55 CD cord-333286-lr32e0w4 90 32 ] ] -RRB- cord-333286-lr32e0w4 90 33 . . . cord-333286-lr32e0w4 91 1 Probiotics probiotic NNS cord-333286-lr32e0w4 91 2 are be VBP cord-333286-lr32e0w4 91 3 taken take VBN cord-333286-lr32e0w4 91 4 up up RP cord-333286-lr32e0w4 91 5 by by IN cord-333286-lr32e0w4 91 6 M M NNP cord-333286-lr32e0w4 91 7 cells cell NNS cord-333286-lr32e0w4 91 8 or or CC cord-333286-lr32e0w4 91 9 by by IN cord-333286-lr32e0w4 91 10 CX3C CX3C NNS cord-333286-lr32e0w4 91 11 chemokine chemokine NN cord-333286-lr32e0w4 91 12 receptor receptor NN cord-333286-lr32e0w4 91 13 1 1 CD cord-333286-lr32e0w4 91 14 ( ( -LRB- cord-333286-lr32e0w4 91 15 CX3CR1)+ CX3CR1)+ NNP cord-333286-lr32e0w4 91 16 macrophages macrophage NNS cord-333286-lr32e0w4 91 17 located locate VBN cord-333286-lr32e0w4 91 18 in in IN cord-333286-lr32e0w4 91 19 the the DT cord-333286-lr32e0w4 91 20 gut gut NN cord-333286-lr32e0w4 91 21 epithelium epithelium NN cord-333286-lr32e0w4 91 22 and and CC cord-333286-lr32e0w4 91 23 then then RB cord-333286-lr32e0w4 91 24 transferred transfer VBN cord-333286-lr32e0w4 91 25 to to IN cord-333286-lr32e0w4 91 26 DCs DCs NNP cord-333286-lr32e0w4 91 27 in in IN cord-333286-lr32e0w4 91 28 the the DT cord-333286-lr32e0w4 91 29 subepithelial subepithelial JJ cord-333286-lr32e0w4 91 30 tissue tissue NN cord-333286-lr32e0w4 91 31 . . . cord-333286-lr32e0w4 92 1 Probiotics probiotic NNS cord-333286-lr32e0w4 92 2 are be VBP cord-333286-lr32e0w4 92 3 able able JJ cord-333286-lr32e0w4 92 4 to to TO cord-333286-lr32e0w4 92 5 modulate modulate VB cord-333286-lr32e0w4 92 6 DC DC NNP cord-333286-lr32e0w4 92 7 polarization polarization NN cord-333286-lr32e0w4 92 8 and and CC cord-333286-lr32e0w4 92 9 function function VB cord-333286-lr32e0w4 92 10 [ [ -LRB- cord-333286-lr32e0w4 92 11 56 56 CD cord-333286-lr32e0w4 92 12 ] ] -RRB- cord-333286-lr32e0w4 92 13 that that WDT cord-333286-lr32e0w4 92 14 influence influence VBP cord-333286-lr32e0w4 92 15 the the DT cord-333286-lr32e0w4 92 16 subsequent subsequent JJ cord-333286-lr32e0w4 92 17 T t NN cord-333286-lr32e0w4 92 18 and and CC cord-333286-lr32e0w4 92 19 B b NN cord-333286-lr32e0w4 92 20 cell cell NN cord-333286-lr32e0w4 92 21 responses response NNS cord-333286-lr32e0w4 92 22 [ [ -LRB- cord-333286-lr32e0w4 92 23 57 57 CD cord-333286-lr32e0w4 92 24 ] ] -RRB- cord-333286-lr32e0w4 92 25 in in IN cord-333286-lr32e0w4 92 26 the the DT cord-333286-lr32e0w4 92 27 inductive inductive JJ cord-333286-lr32e0w4 92 28 sites site NNS cord-333286-lr32e0w4 92 29 ( ( -LRB- cord-333286-lr32e0w4 92 30 Peyer Peyer NNP cord-333286-lr32e0w4 92 31 's 's POS cord-333286-lr32e0w4 92 32 patch patch NN cord-333286-lr32e0w4 92 33 , , , cord-333286-lr32e0w4 92 34 and and CC cord-333286-lr32e0w4 92 35 mesenteric mesenteric JJ cord-333286-lr32e0w4 92 36 lymph lymph NN cord-333286-lr32e0w4 92 37 nodes node NNS cord-333286-lr32e0w4 92 38 ) ) -RRB- cord-333286-lr32e0w4 92 39 . . . cord-333286-lr32e0w4 93 1 T T NNP cord-333286-lr32e0w4 93 2 and and CC cord-333286-lr32e0w4 93 3 B b NN cord-333286-lr32e0w4 93 4 cells cell NNS cord-333286-lr32e0w4 93 5 can can MD cord-333286-lr32e0w4 93 6 also also RB cord-333286-lr32e0w4 93 7 enter enter VB cord-333286-lr32e0w4 93 8 the the DT cord-333286-lr32e0w4 93 9 circulation circulation NN cord-333286-lr32e0w4 93 10 and and CC cord-333286-lr32e0w4 93 11 migrate migrate VB cord-333286-lr32e0w4 93 12 to to IN cord-333286-lr32e0w4 93 13 extraintestinal extraintestinal JJ cord-333286-lr32e0w4 93 14 sites site NNS cord-333286-lr32e0w4 93 15 , , , cord-333286-lr32e0w4 93 16 such such JJ cord-333286-lr32e0w4 93 17 as as IN cord-333286-lr32e0w4 93 18 the the DT cord-333286-lr32e0w4 93 19 respiratory respiratory JJ cord-333286-lr32e0w4 93 20 tract tract NN cord-333286-lr32e0w4 93 21 [ [ -LRB- cord-333286-lr32e0w4 93 22 51 51 CD cord-333286-lr32e0w4 93 23 , , , cord-333286-lr32e0w4 93 24 58 58 CD cord-333286-lr32e0w4 93 25 ] ] -RRB- cord-333286-lr32e0w4 93 26 . . . cord-333286-lr32e0w4 94 1 However however RB cord-333286-lr32e0w4 94 2 , , , cord-333286-lr32e0w4 94 3 the the DT cord-333286-lr32e0w4 94 4 exact exact JJ cord-333286-lr32e0w4 94 5 mechanisms mechanism NNS cord-333286-lr32e0w4 94 6 of of IN cord-333286-lr32e0w4 94 7 probiotics probiotic NNS cord-333286-lr32e0w4 94 8 ( ( -LRB- cord-333286-lr32e0w4 94 9 and and CC cord-333286-lr32e0w4 94 10 their -PRON- PRP$ cord-333286-lr32e0w4 94 11 metabolites metabolite NNS cord-333286-lr32e0w4 94 12 ) ) -RRB- cord-333286-lr32e0w4 94 13 in in IN cord-333286-lr32e0w4 94 14 respiratory respiratory JJ cord-333286-lr32e0w4 94 15 infections infection NNS cord-333286-lr32e0w4 94 16 has have VBZ cord-333286-lr32e0w4 94 17 not not RB cord-333286-lr32e0w4 94 18 been be VBN cord-333286-lr32e0w4 94 19 clearly clearly RB cord-333286-lr32e0w4 94 20 established establish VBN cord-333286-lr32e0w4 94 21 and and CC cord-333286-lr32e0w4 94 22 may may MD cord-333286-lr32e0w4 94 23 be be VB cord-333286-lr32e0w4 94 24 influenced influence VBN cord-333286-lr32e0w4 94 25 by by IN cord-333286-lr32e0w4 94 26 the the DT cord-333286-lr32e0w4 94 27 investigated investigate VBN cord-333286-lr32e0w4 94 28 probiotic probiotic JJ cord-333286-lr32e0w4 94 29 strain strain NN cord-333286-lr32e0w4 94 30 , , , cord-333286-lr32e0w4 94 31 microbiota microbiota NN cord-333286-lr32e0w4 94 32 composition composition NN cord-333286-lr32e0w4 94 33 , , , cord-333286-lr32e0w4 94 34 and and CC cord-333286-lr32e0w4 94 35 immunological immunological JJ cord-333286-lr32e0w4 94 36 status status NN cord-333286-lr32e0w4 94 37 of of IN cord-333286-lr32e0w4 94 38 an an DT cord-333286-lr32e0w4 94 39 individual individual NN cord-333286-lr32e0w4 94 40 . . . cord-333286-lr32e0w4 95 1 In in IN cord-333286-lr32e0w4 95 2 the the DT cord-333286-lr32e0w4 95 3 following follow VBG cord-333286-lr32e0w4 95 4 chapters chapter NNS cord-333286-lr32e0w4 95 5 , , , cord-333286-lr32e0w4 95 6 we -PRON- PRP cord-333286-lr32e0w4 95 7 review review VBP cord-333286-lr32e0w4 95 8 the the DT cord-333286-lr32e0w4 95 9 current current JJ cord-333286-lr32e0w4 95 10 pre pre JJ cord-333286-lr32e0w4 95 11 - - JJ cord-333286-lr32e0w4 95 12 clinical clinical JJ cord-333286-lr32e0w4 95 13 evidence evidence NN cord-333286-lr32e0w4 95 14 of of IN cord-333286-lr32e0w4 95 15 immunomodulatory immunomodulatory JJ cord-333286-lr32e0w4 95 16 and and CC cord-333286-lr32e0w4 95 17 antiviral antiviral JJ cord-333286-lr32e0w4 95 18 mechanisms mechanism NNS cord-333286-lr32e0w4 95 19 of of IN cord-333286-lr32e0w4 95 20 probiotics probiotic NNS cord-333286-lr32e0w4 95 21 against against IN cord-333286-lr32e0w4 95 22 respiratory respiratory JJ cord-333286-lr32e0w4 95 23 virus virus NN cord-333286-lr32e0w4 95 24 infections infection NNS cord-333286-lr32e0w4 95 25 with with IN cord-333286-lr32e0w4 95 26 a a DT cord-333286-lr32e0w4 95 27 focus focus NN cord-333286-lr32e0w4 95 28 on on IN cord-333286-lr32e0w4 95 29 the the DT cord-333286-lr32e0w4 95 30 direct direct JJ cord-333286-lr32e0w4 95 31 stimulatory stimulatory JJ cord-333286-lr32e0w4 95 32 effects effect NNS cord-333286-lr32e0w4 95 33 of of IN cord-333286-lr32e0w4 95 34 probiotics probiotic NNS cord-333286-lr32e0w4 95 35 on on IN cord-333286-lr32e0w4 95 36 virus virus NN cord-333286-lr32e0w4 95 37 - - HYPH cord-333286-lr32e0w4 95 38 infected infect VBN cord-333286-lr32e0w4 95 39 immune immune JJ cord-333286-lr32e0w4 95 40 cells cell NNS cord-333286-lr32e0w4 95 41 and and CC cord-333286-lr32e0w4 95 42 animal animal NN cord-333286-lr32e0w4 95 43 models model NNS cord-333286-lr32e0w4 95 44 . . . cord-333286-lr32e0w4 96 1 Probiotic probiotic JJ cord-333286-lr32e0w4 96 2 bacteria bacteria NNS cord-333286-lr32e0w4 96 3 can can MD cord-333286-lr32e0w4 96 4 engage engage VB cord-333286-lr32e0w4 96 5 and and CC cord-333286-lr32e0w4 96 6 activate activate VB cord-333286-lr32e0w4 96 7 TLRs TLRs NNP cord-333286-lr32e0w4 96 8 leading lead VBG cord-333286-lr32e0w4 96 9 to to IN cord-333286-lr32e0w4 96 10 the the DT cord-333286-lr32e0w4 96 11 activation activation NN cord-333286-lr32e0w4 96 12 of of IN cord-333286-lr32e0w4 96 13 NF nf NN cord-333286-lr32e0w4 96 14 - - HYPH cord-333286-lr32e0w4 96 15 κB κB NNP cord-333286-lr32e0w4 96 16 and and CC cord-333286-lr32e0w4 96 17 IRFs irfs NN cord-333286-lr32e0w4 96 18 in in IN cord-333286-lr32e0w4 96 19 immune immune JJ cord-333286-lr32e0w4 96 20 cells cell NNS cord-333286-lr32e0w4 96 21 that that WDT cord-333286-lr32e0w4 96 22 are be VBP cord-333286-lr32e0w4 96 23 essential essential JJ cord-333286-lr32e0w4 96 24 in in IN cord-333286-lr32e0w4 96 25 antiviral antiviral JJ cord-333286-lr32e0w4 96 26 defense defense NN cord-333286-lr32e0w4 96 27 . . . cord-333286-lr32e0w4 97 1 For for IN cord-333286-lr32e0w4 97 2 example example NN cord-333286-lr32e0w4 97 3 , , , cord-333286-lr32e0w4 97 4 it -PRON- PRP cord-333286-lr32e0w4 97 5 has have VBZ cord-333286-lr32e0w4 97 6 been be VBN cord-333286-lr32e0w4 97 7 demonstrated demonstrate VBN cord-333286-lr32e0w4 97 8 in in IN cord-333286-lr32e0w4 97 9 murine murine JJ cord-333286-lr32e0w4 97 10 bone bone NN cord-333286-lr32e0w4 97 11 marrow marrow NN cord-333286-lr32e0w4 97 12 - - HYPH cord-333286-lr32e0w4 97 13 derived derive VBN cord-333286-lr32e0w4 97 14 DCs dc NNS cord-333286-lr32e0w4 97 15 that that WDT cord-333286-lr32e0w4 97 16 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 97 17 acidophilus acidophilus NN cord-333286-lr32e0w4 97 18 NCFM NCFM NNP cord-333286-lr32e0w4 97 19 and and CC cord-333286-lr32e0w4 97 20 L. L. NNP cord-333286-lr32e0w4 97 21 acidophilus acidophilus NN cord-333286-lr32e0w4 97 22 X37 X37 NNP cord-333286-lr32e0w4 97 23 induce induce VB cord-333286-lr32e0w4 97 24 the the DT cord-333286-lr32e0w4 97 25 upregulation upregulation NN cord-333286-lr32e0w4 97 26 of of IN cord-333286-lr32e0w4 97 27 TLR3 TLR3 NNP cord-333286-lr32e0w4 97 28 , , , cord-333286-lr32e0w4 97 29 IL-12 IL-12 NNP cord-333286-lr32e0w4 97 30 , , , cord-333286-lr32e0w4 97 31 and and CC cord-333286-lr32e0w4 97 32 IFN IFN NNP cord-333286-lr32e0w4 97 33 - - HYPH cord-333286-lr32e0w4 97 34 β β NNP cord-333286-lr32e0w4 97 35 in in IN cord-333286-lr32e0w4 97 36 a a DT cord-333286-lr32e0w4 97 37 TLR2-dependent tlr2-dependent NN cord-333286-lr32e0w4 97 38 manner manner NN cord-333286-lr32e0w4 97 39 [ [ -LRB- cord-333286-lr32e0w4 97 40 59 59 CD cord-333286-lr32e0w4 97 41 ] ] -RRB- cord-333286-lr32e0w4 97 42 . . . cord-333286-lr32e0w4 98 1 In in IN cord-333286-lr32e0w4 98 2 macrophage macrophage NN cord-333286-lr32e0w4 98 3 - - HYPH cord-333286-lr32e0w4 98 4 derived derive VBN cord-333286-lr32e0w4 98 5 RAW264.1 RAW264.1 NNP cord-333286-lr32e0w4 98 6 cells cell NNS cord-333286-lr32e0w4 98 7 , , , cord-333286-lr32e0w4 98 8 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 98 9 gasseri gasseri NN cord-333286-lr32e0w4 98 10 SBT2055 SBT2055 VBG cord-333286-lr32e0w4 98 11 upregulated upregulate VBD cord-333286-lr32e0w4 98 12 IFN IFN NNP cord-333286-lr32e0w4 98 13 - - HYPH cord-333286-lr32e0w4 98 14 β β NNP cord-333286-lr32e0w4 98 15 and and CC cord-333286-lr32e0w4 98 16 myxovirus myxovirus NNP cord-333286-lr32e0w4 98 17 resistance resistance NN cord-333286-lr32e0w4 98 18 ( ( -LRB- cord-333286-lr32e0w4 98 19 Mx)1 Mx)1 NNP cord-333286-lr32e0w4 98 20 mRNA mrna NN cord-333286-lr32e0w4 98 21 expression expression NN cord-333286-lr32e0w4 98 22 [ [ -LRB- cord-333286-lr32e0w4 98 23 60 60 CD cord-333286-lr32e0w4 98 24 ] ] -RRB- cord-333286-lr32e0w4 98 25 and and CC cord-333286-lr32e0w4 98 26 in in IN cord-333286-lr32e0w4 98 27 human human JJ cord-333286-lr32e0w4 98 28 monocyte monocyte NN cord-333286-lr32e0w4 98 29 - - HYPH cord-333286-lr32e0w4 98 30 derived derive VBN cord-333286-lr32e0w4 98 31 macrophages macrophage NNS cord-333286-lr32e0w4 98 32 , , , cord-333286-lr32e0w4 98 33 two two CD cord-333286-lr32e0w4 98 34 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 98 35 rhamnosus rhamnosus NN cord-333286-lr32e0w4 98 36 strains strain NNS cord-333286-lr32e0w4 98 37 , , , cord-333286-lr32e0w4 98 38 GG GG NNP cord-333286-lr32e0w4 98 39 and and CC cord-333286-lr32e0w4 98 40 LC705 LC705 NNP cord-333286-lr32e0w4 98 41 , , , cord-333286-lr32e0w4 98 42 induced induce VBN cord-333286-lr32e0w4 98 43 type type NN cord-333286-lr32e0w4 99 1 I -PRON- PRP cord-333286-lr32e0w4 99 2 IFN IFN NNP cord-333286-lr32e0w4 99 3 - - HYPH cord-333286-lr32e0w4 99 4 dependent dependent JJ cord-333286-lr32e0w4 99 5 gene gene NN cord-333286-lr32e0w4 99 6 activation activation NN cord-333286-lr32e0w4 99 7 [ [ -LRB- cord-333286-lr32e0w4 99 8 61 61 CD cord-333286-lr32e0w4 99 9 ] ] -RRB- cord-333286-lr32e0w4 99 10 . . . cord-333286-lr32e0w4 100 1 Pro pro JJ cord-333286-lr32e0w4 100 2 - - JJ cord-333286-lr32e0w4 100 3 inflammatory inflammatory JJ cord-333286-lr32e0w4 100 4 and and CC cord-333286-lr32e0w4 100 5 IFN IFN NNP cord-333286-lr32e0w4 100 6 - - HYPH cord-333286-lr32e0w4 100 7 regulated regulate VBN cord-333286-lr32e0w4 100 8 genes gene NNS cord-333286-lr32e0w4 100 9 including include VBG cord-333286-lr32e0w4 100 10 IL-6 IL-6 NNP cord-333286-lr32e0w4 100 11 , , , cord-333286-lr32e0w4 100 12 IL-12 IL-12 NNP cord-333286-lr32e0w4 100 13 , , , cord-333286-lr32e0w4 100 14 IL-1β IL-1β NNP cord-333286-lr32e0w4 100 15 , , , cord-333286-lr32e0w4 100 16 IL-8 IL-8 NNP cord-333286-lr32e0w4 100 17 , , , cord-333286-lr32e0w4 100 18 CCL20 CCL20 NNP cord-333286-lr32e0w4 100 19 , , , cord-333286-lr32e0w4 100 20 CXCL10 CXCL10 NNP cord-333286-lr32e0w4 100 21 , , , cord-333286-lr32e0w4 100 22 Mx1 mx1 CD cord-333286-lr32e0w4 100 23 , , , cord-333286-lr32e0w4 100 24 and and CC cord-333286-lr32e0w4 100 25 Mx2 Mx2 NNP cord-333286-lr32e0w4 100 26 were be VBD cord-333286-lr32e0w4 100 27 induced induce VBN cord-333286-lr32e0w4 100 28 by by IN cord-333286-lr32e0w4 100 29 both both CC cord-333286-lr32e0w4 100 30 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 100 31 strains strain NNS cord-333286-lr32e0w4 100 32 . . . cord-333286-lr32e0w4 101 1 In in IN cord-333286-lr32e0w4 101 2 addition addition NN cord-333286-lr32e0w4 101 3 , , , cord-333286-lr32e0w4 101 4 the the DT cord-333286-lr32e0w4 101 5 gene gene NN cord-333286-lr32e0w4 101 6 expression expression NN cord-333286-lr32e0w4 101 7 of of IN cord-333286-lr32e0w4 101 8 TLR3 TLR3 NNP cord-333286-lr32e0w4 101 9 and and CC cord-333286-lr32e0w4 101 10 TLR7 TLR7 NNP cord-333286-lr32e0w4 101 11 , , , cord-333286-lr32e0w4 101 12 receptors receptor NNS cord-333286-lr32e0w4 101 13 recognizing recognize VBG cord-333286-lr32e0w4 101 14 viral viral JJ cord-333286-lr32e0w4 101 15 dsRNA dsrna NN cord-333286-lr32e0w4 101 16 and and CC cord-333286-lr32e0w4 101 17 ssRNA ssRNA NNS cord-333286-lr32e0w4 101 18 , , , cord-333286-lr32e0w4 101 19 respectively respectively RB cord-333286-lr32e0w4 101 20 , , , cord-333286-lr32e0w4 101 21 was be VBD cord-333286-lr32e0w4 101 22 upregulated upregulate VBN cord-333286-lr32e0w4 101 23 by by IN cord-333286-lr32e0w4 101 24 these these DT cord-333286-lr32e0w4 101 25 strains strain NNS cord-333286-lr32e0w4 101 26 . . . cord-333286-lr32e0w4 102 1 TLR3 TLR3 NNP cord-333286-lr32e0w4 102 2 gene gene NN cord-333286-lr32e0w4 102 3 expression expression NN cord-333286-lr32e0w4 102 4 was be VBD cord-333286-lr32e0w4 102 5 upregulated upregulate VBN cord-333286-lr32e0w4 102 6 only only RB cord-333286-lr32e0w4 102 7 by by IN cord-333286-lr32e0w4 102 8 L. L. NNP cord-333286-lr32e0w4 102 9 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 102 10 LC705 LC705 NNP cord-333286-lr32e0w4 102 11 , , , cord-333286-lr32e0w4 102 12 the the DT cord-333286-lr32e0w4 102 13 strain strain NN cord-333286-lr32e0w4 102 14 with with IN cord-333286-lr32e0w4 102 15 higher high JJR cord-333286-lr32e0w4 102 16 antiviral antiviral JJ cord-333286-lr32e0w4 102 17 potential potential NN cord-333286-lr32e0w4 102 18 , , , cord-333286-lr32e0w4 102 19 while while IN cord-333286-lr32e0w4 102 20 TLR7 TLR7 NNP cord-333286-lr32e0w4 102 21 was be VBD cord-333286-lr32e0w4 102 22 moderately moderately RB cord-333286-lr32e0w4 102 23 upregulated upregulate VBN cord-333286-lr32e0w4 102 24 by by IN cord-333286-lr32e0w4 102 25 both both DT cord-333286-lr32e0w4 102 26 strains strain NNS cord-333286-lr32e0w4 102 27 . . . cord-333286-lr32e0w4 103 1 In in IN cord-333286-lr32e0w4 103 2 vitro vitro FW cord-333286-lr32e0w4 103 3 studies study NNS cord-333286-lr32e0w4 103 4 with with IN cord-333286-lr32e0w4 103 5 immune immune JJ cord-333286-lr32e0w4 103 6 cells cell NNS cord-333286-lr32e0w4 103 7 have have VBP cord-333286-lr32e0w4 103 8 also also RB cord-333286-lr32e0w4 103 9 shown show VBN cord-333286-lr32e0w4 103 10 the the DT cord-333286-lr32e0w4 103 11 ability ability NN cord-333286-lr32e0w4 103 12 of of IN cord-333286-lr32e0w4 103 13 probiotics probiotic NNS cord-333286-lr32e0w4 103 14 and and CC cord-333286-lr32e0w4 103 15 their -PRON- PRP$ cord-333286-lr32e0w4 103 16 components component NNS cord-333286-lr32e0w4 103 17 to to TO cord-333286-lr32e0w4 103 18 restrict restrict VB cord-333286-lr32e0w4 103 19 viral viral JJ cord-333286-lr32e0w4 103 20 replication replication NN cord-333286-lr32e0w4 103 21 . . . cord-333286-lr32e0w4 104 1 In in IN cord-333286-lr32e0w4 104 2 human human JJ cord-333286-lr32e0w4 104 3 monocyte monocyte NN cord-333286-lr32e0w4 104 4 - - HYPH cord-333286-lr32e0w4 104 5 derived derive VBN cord-333286-lr32e0w4 104 6 macrophages macrophage NNS cord-333286-lr32e0w4 104 7 , , , cord-333286-lr32e0w4 104 8 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 104 9 strains strain NNS cord-333286-lr32e0w4 104 10 showed show VBD cord-333286-lr32e0w4 104 11 the the DT cord-333286-lr32e0w4 104 12 ability ability NN cord-333286-lr32e0w4 104 13 to to TO cord-333286-lr32e0w4 104 14 prevent prevent VB cord-333286-lr32e0w4 104 15 influenza influenza NN cord-333286-lr32e0w4 104 16 A a DT cord-333286-lr32e0w4 104 17 virus virus NN cord-333286-lr32e0w4 104 18 replication replication NN cord-333286-lr32e0w4 104 19 which which WDT cord-333286-lr32e0w4 104 20 correlated correlate VBD cord-333286-lr32e0w4 104 21 with with IN cord-333286-lr32e0w4 104 22 the the DT cord-333286-lr32e0w4 104 23 ability ability NN cord-333286-lr32e0w4 104 24 to to TO cord-333286-lr32e0w4 104 25 activate activate VB cord-333286-lr32e0w4 104 26 type type NN cord-333286-lr32e0w4 105 1 I -PRON- PRP cord-333286-lr32e0w4 105 2 IFN IFN NNP cord-333286-lr32e0w4 105 3 - - HYPH cord-333286-lr32e0w4 105 4 dependent dependent JJ cord-333286-lr32e0w4 105 5 antiviral antiviral JJ cord-333286-lr32e0w4 105 6 genes gene NNS cord-333286-lr32e0w4 105 7 [ [ -LRB- cord-333286-lr32e0w4 105 8 61 61 CD cord-333286-lr32e0w4 105 9 ] ] -RRB- cord-333286-lr32e0w4 105 10 . . . cord-333286-lr32e0w4 106 1 Similarly similarly RB cord-333286-lr32e0w4 106 2 , , , cord-333286-lr32e0w4 106 3 mouse mouse NN cord-333286-lr32e0w4 106 4 adapted adapt VBD cord-333286-lr32e0w4 106 5 influenza influenza NN cord-333286-lr32e0w4 106 6 A a DT cord-333286-lr32e0w4 106 7 virus virus NN cord-333286-lr32e0w4 106 8 ( ( -LRB- cord-333286-lr32e0w4 106 9 PR8 PR8 NNP cord-333286-lr32e0w4 106 10 ) ) -RRB- cord-333286-lr32e0w4 106 11 titer titer NN cord-333286-lr32e0w4 106 12 was be VBD cord-333286-lr32e0w4 106 13 reduced reduce VBN cord-333286-lr32e0w4 106 14 in in IN cord-333286-lr32e0w4 106 15 RAW264.1 RAW264.1 NNP cord-333286-lr32e0w4 106 16 cells cell NNS cord-333286-lr32e0w4 106 17 by by IN cord-333286-lr32e0w4 106 18 L. L. NNP cord-333286-lr32e0w4 106 19 gasseri gasseri NNP cord-333286-lr32e0w4 106 20 SBT2055 SBT2055 NNP cord-333286-lr32e0w4 106 21 [ [ -LRB- cord-333286-lr32e0w4 106 22 60 60 CD cord-333286-lr32e0w4 106 23 ] ] -RRB- cord-333286-lr32e0w4 106 24 . . . cord-333286-lr32e0w4 107 1 In in IN cord-333286-lr32e0w4 107 2 mouse mouse NN cord-333286-lr32e0w4 107 3 bone bone NN cord-333286-lr32e0w4 107 4 marrow marrow NN cord-333286-lr32e0w4 107 5 DCs DCs NNP cord-333286-lr32e0w4 107 6 , , , cord-333286-lr32e0w4 107 7 the the DT cord-333286-lr32e0w4 107 8 inhibition inhibition NN cord-333286-lr32e0w4 107 9 of of IN cord-333286-lr32e0w4 107 10 viral viral JJ cord-333286-lr32e0w4 107 11 replication replication NN cord-333286-lr32e0w4 107 12 by by IN cord-333286-lr32e0w4 107 13 L. L. NNP cord-333286-lr32e0w4 107 14 acidophilus acidophilus NN cord-333286-lr32e0w4 107 15 ATCC4356 ATCC4356 NNP cord-333286-lr32e0w4 108 1 S s NN cord-333286-lr32e0w4 108 2 - - HYPH cord-333286-lr32e0w4 108 3 layer layer NN cord-333286-lr32e0w4 108 4 protein protein NN cord-333286-lr32e0w4 108 5 was be VBD cord-333286-lr32e0w4 108 6 demonstrated demonstrate VBN cord-333286-lr32e0w4 108 7 [ [ -LRB- cord-333286-lr32e0w4 108 8 62 62 CD cord-333286-lr32e0w4 108 9 , , , cord-333286-lr32e0w4 108 10 63 63 CD cord-333286-lr32e0w4 108 11 ] ] -RRB- cord-333286-lr32e0w4 108 12 . . . cord-333286-lr32e0w4 109 1 Priming priming NN cord-333286-lr32e0w4 109 2 of of IN cord-333286-lr32e0w4 109 3 cells cell NNS cord-333286-lr32e0w4 109 4 with with IN cord-333286-lr32e0w4 109 5 S s NN cord-333286-lr32e0w4 109 6 - - HYPH cord-333286-lr32e0w4 109 7 layer layer NN cord-333286-lr32e0w4 109 8 protein protein NN cord-333286-lr32e0w4 109 9 prior prior RB cord-333286-lr32e0w4 109 10 to to IN cord-333286-lr32e0w4 109 11 H9N2 H9N2 NNP cord-333286-lr32e0w4 109 12 avian avian JJ cord-333286-lr32e0w4 109 13 influenza influenza NN cord-333286-lr32e0w4 109 14 virus virus NN cord-333286-lr32e0w4 109 15 infection infection NN cord-333286-lr32e0w4 109 16 inhibited inhibit VBD cord-333286-lr32e0w4 109 17 the the DT cord-333286-lr32e0w4 109 18 invasion invasion NN cord-333286-lr32e0w4 109 19 and and CC cord-333286-lr32e0w4 109 20 replication replication NN cord-333286-lr32e0w4 109 21 of of IN cord-333286-lr32e0w4 109 22 the the DT cord-333286-lr32e0w4 109 23 virus virus NN cord-333286-lr32e0w4 109 24 , , , cord-333286-lr32e0w4 109 25 stimulated stimulate VBD cord-333286-lr32e0w4 109 26 the the DT cord-333286-lr32e0w4 109 27 type type NN cord-333286-lr32e0w4 109 28 I -PRON- PRP cord-333286-lr32e0w4 109 29 IFN IFN NNP cord-333286-lr32e0w4 109 30 signaling signal VBG cord-333286-lr32e0w4 109 31 pathway pathway NN cord-333286-lr32e0w4 109 32 , , , cord-333286-lr32e0w4 109 33 increased increase VBD cord-333286-lr32e0w4 109 34 IL-10 IL-10 NNP cord-333286-lr32e0w4 109 35 mRNA mRNA NNP cord-333286-lr32e0w4 109 36 , , , cord-333286-lr32e0w4 109 37 and and CC cord-333286-lr32e0w4 109 38 decreased decrease VBD cord-333286-lr32e0w4 109 39 TNF TNF NNP cord-333286-lr32e0w4 109 40 - - HYPH cord-333286-lr32e0w4 109 41 α α NNP cord-333286-lr32e0w4 109 42 mRNA mrna NN cord-333286-lr32e0w4 109 43 expression expression NN cord-333286-lr32e0w4 109 44 [ [ -LRB- cord-333286-lr32e0w4 109 45 62 62 CD cord-333286-lr32e0w4 109 46 ] ] -RRB- cord-333286-lr32e0w4 109 47 . . . cord-333286-lr32e0w4 110 1 Polyinosinic Polyinosinic NNP cord-333286-lr32e0w4 110 2 / / SYM cord-333286-lr32e0w4 110 3 polycytidylic polycytidylic JJ cord-333286-lr32e0w4 110 4 acid acid NN cord-333286-lr32e0w4 110 5 ( ( -LRB- cord-333286-lr32e0w4 110 6 Poly Poly NNP cord-333286-lr32e0w4 110 7 I I NNP cord-333286-lr32e0w4 110 8 / / SYM cord-333286-lr32e0w4 110 9 C C NNP cord-333286-lr32e0w4 110 10 ) ) -RRB- cord-333286-lr32e0w4 110 11 , , , cord-333286-lr32e0w4 110 12 a a DT cord-333286-lr32e0w4 110 13 synthetic synthetic JJ cord-333286-lr32e0w4 110 14 mimic mimic NN cord-333286-lr32e0w4 110 15 of of IN cord-333286-lr32e0w4 110 16 dsRNA dsrna NN cord-333286-lr32e0w4 110 17 , , , cord-333286-lr32e0w4 110 18 is be VBZ cord-333286-lr32e0w4 110 19 widely widely RB cord-333286-lr32e0w4 110 20 used use VBN cord-333286-lr32e0w4 110 21 in in RP cord-333286-lr32e0w4 110 22 in in FW cord-333286-lr32e0w4 110 23 vitro vitro FW cord-333286-lr32e0w4 110 24 studies study NNS cord-333286-lr32e0w4 110 25 to to TO cord-333286-lr32e0w4 110 26 stimulate stimulate VB cord-333286-lr32e0w4 110 27 TLR3 TLR3 NNP cord-333286-lr32e0w4 110 28 . . . cord-333286-lr32e0w4 111 1 It -PRON- PRP cord-333286-lr32e0w4 111 2 induces induce VBZ cord-333286-lr32e0w4 111 3 characteristic characteristic JJ cord-333286-lr32e0w4 111 4 inflammatory inflammatory JJ cord-333286-lr32e0w4 111 5 responses response NNS cord-333286-lr32e0w4 111 6 associated associate VBN cord-333286-lr32e0w4 111 7 with with IN cord-333286-lr32e0w4 111 8 virus virus NN cord-333286-lr32e0w4 111 9 infections infection NNS cord-333286-lr32e0w4 111 10 such such JJ cord-333286-lr32e0w4 111 11 as as IN cord-333286-lr32e0w4 111 12 increased increase VBN cord-333286-lr32e0w4 111 13 production production NN cord-333286-lr32e0w4 111 14 of of IN cord-333286-lr32e0w4 111 15 inflammatory inflammatory JJ cord-333286-lr32e0w4 111 16 cytokines cytokine NNS cord-333286-lr32e0w4 111 17 . . . cord-333286-lr32e0w4 112 1 Stimulation stimulation NN cord-333286-lr32e0w4 112 2 of of IN cord-333286-lr32e0w4 112 3 airway airway NN cord-333286-lr32e0w4 112 4 epithelial epithelial JJ cord-333286-lr32e0w4 112 5 cells cell NNS cord-333286-lr32e0w4 112 6 with with IN cord-333286-lr32e0w4 112 7 Poly Poly NNP cord-333286-lr32e0w4 112 8 I I NNP cord-333286-lr32e0w4 112 9 / / SYM cord-333286-lr32e0w4 112 10 C C NNP cord-333286-lr32e0w4 112 11 has have VBZ cord-333286-lr32e0w4 112 12 been be VBN cord-333286-lr32e0w4 112 13 found find VBN cord-333286-lr32e0w4 112 14 to to TO cord-333286-lr32e0w4 112 15 closely closely RB cord-333286-lr32e0w4 112 16 mimic mimic VB cord-333286-lr32e0w4 112 17 inflammatory inflammatory JJ cord-333286-lr32e0w4 112 18 responses response NNS cord-333286-lr32e0w4 112 19 associated associate VBN cord-333286-lr32e0w4 112 20 with with IN cord-333286-lr32e0w4 112 21 respiratory respiratory JJ cord-333286-lr32e0w4 112 22 virus virus NN cord-333286-lr32e0w4 112 23 infections infection NNS cord-333286-lr32e0w4 112 24 [ [ -LRB- cord-333286-lr32e0w4 112 25 64 64 CD cord-333286-lr32e0w4 112 26 ] ] -RRB- cord-333286-lr32e0w4 112 27 . . . cord-333286-lr32e0w4 113 1 Poly Poly NNP cord-333286-lr32e0w4 113 2 I I NNP cord-333286-lr32e0w4 113 3 / / SYM cord-333286-lr32e0w4 113 4 C C NNP cord-333286-lr32e0w4 113 5 challenge challenge NN cord-333286-lr32e0w4 113 6 in in IN cord-333286-lr32e0w4 113 7 peripheral peripheral JJ cord-333286-lr32e0w4 113 8 blood blood NN cord-333286-lr32e0w4 113 9 mononuclear mononuclear NN cord-333286-lr32e0w4 113 10 cells cell NNS cord-333286-lr32e0w4 113 11 ( ( -LRB- cord-333286-lr32e0w4 113 12 PBMCs pbmc NNS cord-333286-lr32e0w4 113 13 ) ) -RRB- cord-333286-lr32e0w4 113 14 induced induce VBN cord-333286-lr32e0w4 113 15 changes change NNS cord-333286-lr32e0w4 113 16 in in IN cord-333286-lr32e0w4 113 17 the the DT cord-333286-lr32e0w4 113 18 gene gene NN cord-333286-lr32e0w4 113 19 expression expression NN cord-333286-lr32e0w4 113 20 of of IN cord-333286-lr32e0w4 113 21 TLR3 TLR3 NNP cord-333286-lr32e0w4 113 22 , , , cord-333286-lr32e0w4 113 23 IFN IFN NNP cord-333286-lr32e0w4 113 24 , , , cord-333286-lr32e0w4 113 25 and and CC cord-333286-lr32e0w4 113 26 NF NF NNP cord-333286-lr32e0w4 113 27 - - HYPH cord-333286-lr32e0w4 113 28 kB kB NNP cord-333286-lr32e0w4 113 29 - - HYPH cord-333286-lr32e0w4 113 30 dependent dependent JJ cord-333286-lr32e0w4 113 31 pathways pathway NNS cord-333286-lr32e0w4 113 32 similar similar JJ cord-333286-lr32e0w4 113 33 to to IN cord-333286-lr32e0w4 113 34 acute acute JJ cord-333286-lr32e0w4 113 35 viral viral JJ cord-333286-lr32e0w4 113 36 infections infection NNS cord-333286-lr32e0w4 113 37 [ [ -LRB- cord-333286-lr32e0w4 113 38 63 63 CD cord-333286-lr32e0w4 113 39 ] ] -RRB- cord-333286-lr32e0w4 113 40 . . . cord-333286-lr32e0w4 114 1 Moreover moreover RB cord-333286-lr32e0w4 114 2 , , , cord-333286-lr32e0w4 114 3 Poly Poly NNP cord-333286-lr32e0w4 114 4 I I NNP cord-333286-lr32e0w4 114 5 / / SYM cord-333286-lr32e0w4 114 6 C C NNP cord-333286-lr32e0w4 114 7 was be VBD cord-333286-lr32e0w4 114 8 able able JJ cord-333286-lr32e0w4 114 9 to to TO cord-333286-lr32e0w4 114 10 induce induce VB cord-333286-lr32e0w4 114 11 a a DT cord-333286-lr32e0w4 114 12 pulmonary pulmonary JJ cord-333286-lr32e0w4 114 13 dysfunction dysfunction NN cord-333286-lr32e0w4 114 14 similar similar JJ cord-333286-lr32e0w4 114 15 to to IN cord-333286-lr32e0w4 114 16 RSV RSV NNP cord-333286-lr32e0w4 114 17 in in IN cord-333286-lr32e0w4 114 18 a a DT cord-333286-lr32e0w4 114 19 mouse mouse NN cord-333286-lr32e0w4 114 20 model model NN cord-333286-lr32e0w4 114 21 [ [ -LRB- cord-333286-lr32e0w4 114 22 65 65 CD cord-333286-lr32e0w4 114 23 ] ] -RRB- cord-333286-lr32e0w4 114 24 . . . cord-333286-lr32e0w4 115 1 Probiotic probiotic JJ cord-333286-lr32e0w4 115 2 bacteria bacteria NNS cord-333286-lr32e0w4 115 3 have have VBP cord-333286-lr32e0w4 115 4 shown show VBN cord-333286-lr32e0w4 115 5 the the DT cord-333286-lr32e0w4 115 6 ability ability NN cord-333286-lr32e0w4 115 7 to to TO cord-333286-lr32e0w4 115 8 modulate modulate VB cord-333286-lr32e0w4 115 9 Poly Poly NNP cord-333286-lr32e0w4 115 10 I I NNP cord-333286-lr32e0w4 115 11 / / SYM cord-333286-lr32e0w4 115 12 C c NN cord-333286-lr32e0w4 115 13 - - HYPH cord-333286-lr32e0w4 115 14 induced induce VBN cord-333286-lr32e0w4 115 15 responses response NNS cord-333286-lr32e0w4 115 16 . . . cord-333286-lr32e0w4 116 1 Studies study NNS cord-333286-lr32e0w4 116 2 with with IN cord-333286-lr32e0w4 116 3 heat heat NN cord-333286-lr32e0w4 116 4 - - HYPH cord-333286-lr32e0w4 116 5 killed kill VBN cord-333286-lr32e0w4 116 6 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 116 7 casei casei NN cord-333286-lr32e0w4 116 8 CRL431 CRL431 NNP cord-333286-lr32e0w4 116 9 showed show VBD cord-333286-lr32e0w4 116 10 that that IN cord-333286-lr32e0w4 116 11 the the DT cord-333286-lr32e0w4 116 12 strain strain NN cord-333286-lr32e0w4 116 13 reduced reduce VBN cord-333286-lr32e0w4 116 14 TNF TNF NNP cord-333286-lr32e0w4 116 15 - - HYPH cord-333286-lr32e0w4 116 16 α α NNP cord-333286-lr32e0w4 116 17 , , , cord-333286-lr32e0w4 116 18 IFN IFN NNP cord-333286-lr32e0w4 116 19 - - HYPH cord-333286-lr32e0w4 116 20 γ γ NNP cord-333286-lr32e0w4 116 21 , , , cord-333286-lr32e0w4 116 22 and and CC cord-333286-lr32e0w4 116 23 IL-17 IL-17 NNP cord-333286-lr32e0w4 116 24 levels level NNS cord-333286-lr32e0w4 116 25 when when WRB cord-333286-lr32e0w4 116 26 it -PRON- PRP cord-333286-lr32e0w4 116 27 was be VBD cord-333286-lr32e0w4 116 28 introduced introduce VBN cord-333286-lr32e0w4 116 29 before before RB cord-333286-lr32e0w4 116 30 or or CC cord-333286-lr32e0w4 116 31 simultaneously simultaneously RB cord-333286-lr32e0w4 116 32 with with IN cord-333286-lr32e0w4 116 33 Poly Poly NNP cord-333286-lr32e0w4 116 34 I I NNP cord-333286-lr32e0w4 116 35 / / SYM cord-333286-lr32e0w4 116 36 C C NNP cord-333286-lr32e0w4 116 37 challenge challenge NN cord-333286-lr32e0w4 116 38 in in IN cord-333286-lr32e0w4 116 39 PBMCs PBMCs NNP cord-333286-lr32e0w4 116 40 alone alone RB cord-333286-lr32e0w4 116 41 and and CC cord-333286-lr32e0w4 116 42 in in IN cord-333286-lr32e0w4 116 43 a a DT cord-333286-lr32e0w4 116 44 co co NN cord-333286-lr32e0w4 116 45 - - NN cord-333286-lr32e0w4 116 46 culture culture JJ cord-333286-lr32e0w4 116 47 system system NN cord-333286-lr32e0w4 116 48 with with IN cord-333286-lr32e0w4 116 49 alveolar alveolar JJ cord-333286-lr32e0w4 116 50 epithelial epithelial JJ cord-333286-lr32e0w4 116 51 cell cell NN cord-333286-lr32e0w4 116 52 line line NN cord-333286-lr32e0w4 116 53 A549 a549 JJ cord-333286-lr32e0w4 116 54 [ [ -LRB- cord-333286-lr32e0w4 116 55 66 66 CD cord-333286-lr32e0w4 116 56 ] ] -RRB- cord-333286-lr32e0w4 116 57 . . . cord-333286-lr32e0w4 117 1 IL-10 IL-10 NNP cord-333286-lr32e0w4 117 2 and and CC cord-333286-lr32e0w4 117 3 IL-29 IL-29 NNP cord-333286-lr32e0w4 117 4 ( ( -LRB- cord-333286-lr32e0w4 117 5 also also RB cord-333286-lr32e0w4 117 6 known know VBN cord-333286-lr32e0w4 117 7 as as IN cord-333286-lr32e0w4 117 8 IFN IFN NNP cord-333286-lr32e0w4 117 9 - - HYPH cord-333286-lr32e0w4 117 10 λ1 λ1 NNP cord-333286-lr32e0w4 117 11 ) ) -RRB- cord-333286-lr32e0w4 117 12 were be VBD cord-333286-lr32e0w4 117 13 induced induce VBN cord-333286-lr32e0w4 117 14 in in IN cord-333286-lr32e0w4 117 15 response response NN cord-333286-lr32e0w4 117 16 to to IN cord-333286-lr32e0w4 117 17 Poly Poly NNP cord-333286-lr32e0w4 117 18 I I NNP cord-333286-lr32e0w4 117 19 / / SYM cord-333286-lr32e0w4 117 20 C C NNP cord-333286-lr32e0w4 117 21 together together RB cord-333286-lr32e0w4 117 22 with with IN cord-333286-lr32e0w4 117 23 heat heat NN cord-333286-lr32e0w4 117 24 - - HYPH cord-333286-lr32e0w4 117 25 killed kill VBN cord-333286-lr32e0w4 117 26 L. L. NNP cord-333286-lr32e0w4 117 27 casei casei NNP cord-333286-lr32e0w4 117 28 CRL431 CRL431 NNP cord-333286-lr32e0w4 117 29 , , , cord-333286-lr32e0w4 117 30 indicating indicate VBG cord-333286-lr32e0w4 117 31 a a DT cord-333286-lr32e0w4 117 32 boost boost NN cord-333286-lr32e0w4 117 33 in in IN cord-333286-lr32e0w4 117 34 pro pro JJ cord-333286-lr32e0w4 117 35 - - JJ cord-333286-lr32e0w4 117 36 inflammatory inflammatory JJ cord-333286-lr32e0w4 117 37 responses response NNS cord-333286-lr32e0w4 117 38 and and CC cord-333286-lr32e0w4 117 39 the the DT cord-333286-lr32e0w4 117 40 activation activation NN cord-333286-lr32e0w4 117 41 of of IN cord-333286-lr32e0w4 117 42 anti anti JJ cord-333286-lr32e0w4 117 43 - - JJ cord-333286-lr32e0w4 117 44 inflammatory inflammatory JJ cord-333286-lr32e0w4 117 45 and and CC cord-333286-lr32e0w4 117 46 antiviral antiviral JJ cord-333286-lr32e0w4 117 47 mechanisms mechanism NNS cord-333286-lr32e0w4 117 48 . . . cord-333286-lr32e0w4 118 1 In in IN cord-333286-lr32e0w4 118 2 the the DT cord-333286-lr32e0w4 118 3 intestinal intestinal JJ cord-333286-lr32e0w4 118 4 human human JJ cord-333286-lr32e0w4 118 5 colon colon NN cord-333286-lr32e0w4 118 6 cell cell NN cord-333286-lr32e0w4 118 7 line line NN cord-333286-lr32e0w4 118 8 ( ( -LRB- cord-333286-lr32e0w4 118 9 HCT116 HCT116 NNP cord-333286-lr32e0w4 118 10 ) ) -RRB- cord-333286-lr32e0w4 118 11 , , , cord-333286-lr32e0w4 118 12 regulation regulation NN cord-333286-lr32e0w4 118 13 of of IN cord-333286-lr32e0w4 118 14 Poly Poly NNP cord-333286-lr32e0w4 118 15 I I NNP cord-333286-lr32e0w4 118 16 / / SYM cord-333286-lr32e0w4 118 17 C C NNP cord-333286-lr32e0w4 118 18 response response NN cord-333286-lr32e0w4 118 19 by by IN cord-333286-lr32e0w4 118 20 Lactiplantibacillus Lactiplantibacillus NNP cord-333286-lr32e0w4 118 21 plantarum plantarum NNS cord-333286-lr32e0w4 118 22 subsp subsp NN cord-333286-lr32e0w4 118 23 . . . cord-333286-lr32e0w4 119 1 plantarum plantarum NNP cord-333286-lr32e0w4 119 2 DU1 DU1 NNP cord-333286-lr32e0w4 119 3 , , , cord-333286-lr32e0w4 119 4 Latilactobacillus Latilactobacillus NNP cord-333286-lr32e0w4 119 5 sakei sakei NNP cord-333286-lr32e0w4 119 6 DU2 DU2 NNP cord-333286-lr32e0w4 119 7 , , , cord-333286-lr32e0w4 119 8 and and CC cord-333286-lr32e0w4 119 9 Weissella Weissella NNP cord-333286-lr32e0w4 119 10 cibaria cibaria NNP cord-333286-lr32e0w4 119 11 DU1 DU1 NNP cord-333286-lr32e0w4 119 12 was be VBD cord-333286-lr32e0w4 119 13 examined examine VBN cord-333286-lr32e0w4 119 14 [ [ -LRB- cord-333286-lr32e0w4 119 15 67 67 CD cord-333286-lr32e0w4 119 16 ] ] -RRB- cord-333286-lr32e0w4 119 17 . . . cord-333286-lr32e0w4 120 1 These these DT cord-333286-lr32e0w4 120 2 strains strain NNS cord-333286-lr32e0w4 120 3 modified modify VBD cord-333286-lr32e0w4 120 4 Poly Poly NNP cord-333286-lr32e0w4 120 5 I I NNP cord-333286-lr32e0w4 120 6 / / SYM cord-333286-lr32e0w4 120 7 C C NNP cord-333286-lr32e0w4 120 8 - - HYPH cord-333286-lr32e0w4 120 9 induced induce VBN cord-333286-lr32e0w4 120 10 expression expression NN cord-333286-lr32e0w4 120 11 of of IN cord-333286-lr32e0w4 120 12 cytokines cytokine NNS cord-333286-lr32e0w4 120 13 and and CC cord-333286-lr32e0w4 120 14 antiviral antiviral JJ cord-333286-lr32e0w4 120 15 genes gene NNS cord-333286-lr32e0w4 120 16 by by IN cord-333286-lr32e0w4 120 17 upregulating upregulate VBG cord-333286-lr32e0w4 120 18 IFN IFN NNP cord-333286-lr32e0w4 120 19 - - HYPH cord-333286-lr32e0w4 120 20 β β NNP cord-333286-lr32e0w4 120 21 , , , cord-333286-lr32e0w4 120 22 TLR3 TLR3 NNP cord-333286-lr32e0w4 120 23 , , , cord-333286-lr32e0w4 120 24 and and CC cord-333286-lr32e0w4 120 25 RIG rig NN cord-333286-lr32e0w4 120 26 - - : cord-333286-lr32e0w4 120 27 I -PRON- PRP cord-333286-lr32e0w4 120 28 while while IN cord-333286-lr32e0w4 120 29 dampening dampen VBG cord-333286-lr32e0w4 120 30 the the DT cord-333286-lr32e0w4 120 31 inflammatory inflammatory JJ cord-333286-lr32e0w4 120 32 response response NN cord-333286-lr32e0w4 120 33 . . . cord-333286-lr32e0w4 121 1 Moreover moreover RB cord-333286-lr32e0w4 121 2 , , , cord-333286-lr32e0w4 121 3 the the DT cord-333286-lr32e0w4 121 4 probiotic probiotic JJ cord-333286-lr32e0w4 121 5 strains strain NNS cord-333286-lr32e0w4 121 6 induced induce VBN cord-333286-lr32e0w4 121 7 IFN IFN NNP cord-333286-lr32e0w4 121 8 - - HYPH cord-333286-lr32e0w4 121 9 α α NNP cord-333286-lr32e0w4 121 10 , , , cord-333286-lr32e0w4 121 11 IFN IFN NNP cord-333286-lr32e0w4 121 12 - - HYPH cord-333286-lr32e0w4 121 13 β β NNP cord-333286-lr32e0w4 121 14 , , , cord-333286-lr32e0w4 121 15 and and CC cord-333286-lr32e0w4 121 16 IL-10 IL-10 NNP cord-333286-lr32e0w4 121 17 and and CC cord-333286-lr32e0w4 121 18 reduced reduce VBD cord-333286-lr32e0w4 121 19 the the DT cord-333286-lr32e0w4 121 20 expression expression NN cord-333286-lr32e0w4 121 21 of of IN cord-333286-lr32e0w4 121 22 inflammatory inflammatory JJ cord-333286-lr32e0w4 121 23 cytokines cytokine NNS cord-333286-lr32e0w4 121 24 IL-1β IL-1β NNP cord-333286-lr32e0w4 121 25 and and CC cord-333286-lr32e0w4 121 26 TNF TNF NNP cord-333286-lr32e0w4 121 27 - - HYPH cord-333286-lr32e0w4 121 28 α α NNP cord-333286-lr32e0w4 121 29 in in IN cord-333286-lr32e0w4 121 30 human human JJ cord-333286-lr32e0w4 121 31 monocytic monocytic NNP cord-333286-lr32e0w4 121 32 THP-1 THP-1 NNP cord-333286-lr32e0w4 121 33 macrophages macrophage NNS cord-333286-lr32e0w4 121 34 [ [ -LRB- cord-333286-lr32e0w4 121 35 67 67 CD cord-333286-lr32e0w4 121 36 ] ] -RRB- cord-333286-lr32e0w4 121 37 . . . cord-333286-lr32e0w4 122 1 In in IN cord-333286-lr32e0w4 122 2 addition addition NN cord-333286-lr32e0w4 122 3 to to IN cord-333286-lr32e0w4 122 4 the the DT cord-333286-lr32e0w4 122 5 pro pro JJ cord-333286-lr32e0w4 122 6 - - JJ cord-333286-lr32e0w4 122 7 inflammatory inflammatory JJ cord-333286-lr32e0w4 122 8 and and CC cord-333286-lr32e0w4 122 9 antiviral antiviral JJ cord-333286-lr32e0w4 122 10 gene gene NN cord-333286-lr32e0w4 122 11 activation activation NN cord-333286-lr32e0w4 122 12 described describe VBN cord-333286-lr32e0w4 122 13 above above RB cord-333286-lr32e0w4 122 14 , , , cord-333286-lr32e0w4 122 15 also also RB cord-333286-lr32e0w4 122 16 direct direct JJ cord-333286-lr32e0w4 122 17 interactions interaction NNS cord-333286-lr32e0w4 122 18 of of IN cord-333286-lr32e0w4 122 19 viruses virus NNS cord-333286-lr32e0w4 122 20 and and CC cord-333286-lr32e0w4 122 21 probiotic probiotic JJ cord-333286-lr32e0w4 122 22 bacteria bacteria NNS cord-333286-lr32e0w4 122 23 have have VBP cord-333286-lr32e0w4 122 24 been be VBN cord-333286-lr32e0w4 122 25 demonstrated demonstrate VBN cord-333286-lr32e0w4 122 26 between between IN cord-333286-lr32e0w4 122 27 porcine porcine JJ cord-333286-lr32e0w4 122 28 influenza influenza NN cord-333286-lr32e0w4 122 29 A a DT cord-333286-lr32e0w4 122 30 virus virus NN cord-333286-lr32e0w4 122 31 and and CC cord-333286-lr32e0w4 122 32 Enterococcus Enterococcus NNP cord-333286-lr32e0w4 122 33 faecium faecium NN cord-333286-lr32e0w4 122 34 in in IN cord-333286-lr32e0w4 122 35 vitro vitro FW cord-333286-lr32e0w4 122 36 [ [ -LRB- cord-333286-lr32e0w4 122 37 68 68 CD cord-333286-lr32e0w4 122 38 ] ] -RRB- cord-333286-lr32e0w4 122 39 . . . cord-333286-lr32e0w4 123 1 Similar similar JJ cord-333286-lr32e0w4 123 2 upregulation upregulation NN cord-333286-lr32e0w4 123 3 of of IN cord-333286-lr32e0w4 123 4 IFN IFN NNP cord-333286-lr32e0w4 123 5 response response NN cord-333286-lr32e0w4 123 6 by by IN cord-333286-lr32e0w4 123 7 probiotics probiotic NNS cord-333286-lr32e0w4 123 8 has have VBZ cord-333286-lr32e0w4 123 9 been be VBN cord-333286-lr32e0w4 123 10 shown show VBN cord-333286-lr32e0w4 123 11 in in IN cord-333286-lr32e0w4 123 12 several several JJ cord-333286-lr32e0w4 123 13 studies study NNS cord-333286-lr32e0w4 123 14 in in IN cord-333286-lr32e0w4 123 15 intestinal intestinal JJ cord-333286-lr32e0w4 123 16 epithelial epithelial JJ cord-333286-lr32e0w4 123 17 cells cell NNS cord-333286-lr32e0w4 123 18 [ [ -LRB- cord-333286-lr32e0w4 123 19 69 69 CD cord-333286-lr32e0w4 123 20 ] ] -RRB- cord-333286-lr32e0w4 123 21 [ [ -LRB- cord-333286-lr32e0w4 123 22 70 70 CD cord-333286-lr32e0w4 123 23 ] ] -RRB- cord-333286-lr32e0w4 123 24 [ [ -LRB- cord-333286-lr32e0w4 123 25 71 71 CD cord-333286-lr32e0w4 123 26 ] ] -RRB- cord-333286-lr32e0w4 123 27 and and CC cord-333286-lr32e0w4 123 28 macrophages macrophage NNS cord-333286-lr32e0w4 123 29 [ [ -LRB- cord-333286-lr32e0w4 123 30 68 68 CD cord-333286-lr32e0w4 123 31 , , , cord-333286-lr32e0w4 123 32 72 72 CD cord-333286-lr32e0w4 123 33 ] ] -RRB- cord-333286-lr32e0w4 123 34 . . . cord-333286-lr32e0w4 124 1 Overall overall RB cord-333286-lr32e0w4 124 2 , , , cord-333286-lr32e0w4 124 3 the the DT cord-333286-lr32e0w4 124 4 in in FW cord-333286-lr32e0w4 124 5 vitro vitro FW cord-333286-lr32e0w4 124 6 studies study NNS cord-333286-lr32e0w4 124 7 indicate indicate VBP cord-333286-lr32e0w4 124 8 that that IN cord-333286-lr32e0w4 124 9 probiotics probiotic NNS cord-333286-lr32e0w4 124 10 may may MD cord-333286-lr32e0w4 124 11 stimulate stimulate VB cord-333286-lr32e0w4 124 12 similar similar JJ cord-333286-lr32e0w4 124 13 innate innate JJ cord-333286-lr32e0w4 124 14 immune immune JJ cord-333286-lr32e0w4 124 15 pathways pathway NNS cord-333286-lr32e0w4 124 16 to to IN cord-333286-lr32e0w4 124 17 respiratory respiratory JJ cord-333286-lr32e0w4 124 18 viruses virus NNS cord-333286-lr32e0w4 124 19 and and CC cord-333286-lr32e0w4 124 20 potentially potentially RB cord-333286-lr32e0w4 124 21 modulate modulate VB cord-333286-lr32e0w4 124 22 virus virus NN cord-333286-lr32e0w4 124 23 - - HYPH cord-333286-lr32e0w4 124 24 induced induce VBN cord-333286-lr32e0w4 124 25 immune immune JJ cord-333286-lr32e0w4 124 26 responses response NNS cord-333286-lr32e0w4 124 27 . . . cord-333286-lr32e0w4 125 1 Several several JJ cord-333286-lr32e0w4 125 2 mouse mouse NN cord-333286-lr32e0w4 125 3 studies study NNS cord-333286-lr32e0w4 125 4 have have VBP cord-333286-lr32e0w4 125 5 shown show VBN cord-333286-lr32e0w4 125 6 that that IN cord-333286-lr32e0w4 125 7 the the DT cord-333286-lr32e0w4 125 8 administration administration NN cord-333286-lr32e0w4 125 9 of of IN cord-333286-lr32e0w4 125 10 probiotics probiotic NNS cord-333286-lr32e0w4 125 11 can can MD cord-333286-lr32e0w4 125 12 help help VB cord-333286-lr32e0w4 125 13 to to TO cord-333286-lr32e0w4 125 14 fight fight VB cord-333286-lr32e0w4 125 15 against against IN cord-333286-lr32e0w4 125 16 viral viral JJ cord-333286-lr32e0w4 125 17 RTIs rti NNS cord-333286-lr32e0w4 125 18 . . . cord-333286-lr32e0w4 126 1 The the DT cord-333286-lr32e0w4 126 2 beneficial beneficial JJ cord-333286-lr32e0w4 126 3 effects effect NNS cord-333286-lr32e0w4 126 4 of of IN cord-333286-lr32e0w4 126 5 oral oral JJ cord-333286-lr32e0w4 126 6 probiotic probiotic JJ cord-333286-lr32e0w4 126 7 supplementation supplementation NN cord-333286-lr32e0w4 126 8 on on IN cord-333286-lr32e0w4 126 9 mouse mouse NN cord-333286-lr32e0w4 126 10 survival survival NN cord-333286-lr32e0w4 126 11 and and CC cord-333286-lr32e0w4 126 12 health health NN cord-333286-lr32e0w4 126 13 status status NN cord-333286-lr32e0w4 126 14 is be VBZ cord-333286-lr32e0w4 126 15 well well RB cord-333286-lr32e0w4 126 16 demonstrated demonstrate VBN cord-333286-lr32e0w4 126 17 [ [ -LRB- cord-333286-lr32e0w4 126 18 60 60 CD cord-333286-lr32e0w4 126 19 , , , cord-333286-lr32e0w4 126 20 [ [ -LRB- cord-333286-lr32e0w4 126 21 73 73 CD cord-333286-lr32e0w4 126 22 ] ] -RRB- cord-333286-lr32e0w4 126 23 [ [ -LRB- cord-333286-lr32e0w4 126 24 74 74 CD cord-333286-lr32e0w4 126 25 ] ] -RRB- cord-333286-lr32e0w4 126 26 [ [ -LRB- cord-333286-lr32e0w4 126 27 75 75 CD cord-333286-lr32e0w4 126 28 ] ] -RRB- cord-333286-lr32e0w4 126 29 [ [ -LRB- cord-333286-lr32e0w4 126 30 76 76 CD cord-333286-lr32e0w4 126 31 ] ] -RRB- cord-333286-lr32e0w4 126 32 [ [ -LRB- cord-333286-lr32e0w4 126 33 77 77 CD cord-333286-lr32e0w4 126 34 ] ] -RRB- cord-333286-lr32e0w4 126 35 . . . cord-333286-lr32e0w4 127 1 For for IN cord-333286-lr32e0w4 127 2 example example NN cord-333286-lr32e0w4 127 3 , , , cord-333286-lr32e0w4 127 4 oral oral JJ cord-333286-lr32e0w4 127 5 administration administration NN cord-333286-lr32e0w4 127 6 of of IN cord-333286-lr32e0w4 127 7 Lacticaseibacillus Lacticaseibacillus NNP cord-333286-lr32e0w4 127 8 paracasei paracasei NN cord-333286-lr32e0w4 127 9 subsp subsp NN cord-333286-lr32e0w4 127 10 . . . cord-333286-lr32e0w4 128 1 paracasei paracasei NNP cord-333286-lr32e0w4 128 2 CNCM- CNCM- NNP cord-333286-lr32e0w4 129 1 I-1518 I-1518 NNP cord-333286-lr32e0w4 129 2 [ [ -LRB- cord-333286-lr32e0w4 129 3 74 74 CD cord-333286-lr32e0w4 129 4 ] ] -RRB- cord-333286-lr32e0w4 130 1 , , , cord-333286-lr32e0w4 130 2 L. L. NNP cord-333286-lr32e0w4 130 3 gasseri gasseri NNP cord-333286-lr32e0w4 130 4 LG2055 lg2055 NN cord-333286-lr32e0w4 130 5 [ [ -LRB- cord-333286-lr32e0w4 130 6 60 60 CD cord-333286-lr32e0w4 130 7 ] ] -RRB- cord-333286-lr32e0w4 130 8 , , , cord-333286-lr32e0w4 130 9 and and CC cord-333286-lr32e0w4 130 10 Bifidobacterium Bifidobacterium NNP cord-333286-lr32e0w4 130 11 longum longum NN cord-333286-lr32e0w4 130 12 MM-2 MM-2 NNP cord-333286-lr32e0w4 130 13 [ [ -LRB- cord-333286-lr32e0w4 130 14 75 75 CD cord-333286-lr32e0w4 130 15 ] ] -RRB- cord-333286-lr32e0w4 130 16 reduced reduce VBN cord-333286-lr32e0w4 130 17 mortality mortality NN cord-333286-lr32e0w4 130 18 and and CC cord-333286-lr32e0w4 130 19 improved improved JJ cord-333286-lr32e0w4 130 20 immune immune JJ cord-333286-lr32e0w4 130 21 control control NN cord-333286-lr32e0w4 130 22 in in IN cord-333286-lr32e0w4 130 23 influenza influenza NN cord-333286-lr32e0w4 130 24 - - HYPH cord-333286-lr32e0w4 130 25 infected infect VBN cord-333286-lr32e0w4 130 26 mice mouse NNS cord-333286-lr32e0w4 130 27 . . . cord-333286-lr32e0w4 131 1 Probiotic probiotic JJ cord-333286-lr32e0w4 131 2 administration administration NN cord-333286-lr32e0w4 131 3 resulted result VBD cord-333286-lr32e0w4 131 4 in in IN cord-333286-lr32e0w4 131 5 better well JJR cord-333286-lr32e0w4 131 6 health health NN cord-333286-lr32e0w4 131 7 status status NN cord-333286-lr32e0w4 131 8 of of IN cord-333286-lr32e0w4 131 9 the the DT cord-333286-lr32e0w4 131 10 mice mouse NNS cord-333286-lr32e0w4 131 11 and and CC cord-333286-lr32e0w4 131 12 lower low JJR cord-333286-lr32e0w4 131 13 virus virus NN cord-333286-lr32e0w4 131 14 loads load NNS cord-333286-lr32e0w4 131 15 in in IN cord-333286-lr32e0w4 131 16 the the DT cord-333286-lr32e0w4 131 17 lungs lung NNS cord-333286-lr32e0w4 131 18 after after IN cord-333286-lr32e0w4 131 19 influenza influenza NN cord-333286-lr32e0w4 131 20 infection infection NN cord-333286-lr32e0w4 131 21 . . . cord-333286-lr32e0w4 132 1 In in IN cord-333286-lr32e0w4 132 2 addition addition NN cord-333286-lr32e0w4 132 3 , , , cord-333286-lr32e0w4 132 4 the the DT cord-333286-lr32e0w4 132 5 immune immune JJ cord-333286-lr32e0w4 132 6 response response NN cord-333286-lr32e0w4 132 7 to to IN cord-333286-lr32e0w4 132 8 viruses virus NNS cord-333286-lr32e0w4 132 9 was be VBD cord-333286-lr32e0w4 132 10 modulated modulate VBN cord-333286-lr32e0w4 132 11 by by IN cord-333286-lr32e0w4 132 12 probiotic probiotic JJ cord-333286-lr32e0w4 132 13 administration administration NN cord-333286-lr32e0w4 132 14 . . . cord-333286-lr32e0w4 133 1 For for IN cord-333286-lr32e0w4 133 2 instance instance NN cord-333286-lr32e0w4 133 3 , , , cord-333286-lr32e0w4 133 4 L. L. NNP cord-333286-lr32e0w4 133 5 paracasei paracasei NNP cord-333286-lr32e0w4 133 6 CNCM CNCM NNP cord-333286-lr32e0w4 133 7 - - HYPH cord-333286-lr32e0w4 133 8 I-1518 I-1518 NNP cord-333286-lr32e0w4 133 9 modified modify VBD cord-333286-lr32e0w4 133 10 the the DT cord-333286-lr32e0w4 133 11 pro pro JJ cord-333286-lr32e0w4 133 12 - - JJ cord-333286-lr32e0w4 133 13 and and CC cord-333286-lr32e0w4 133 14 anti anti JJ cord-333286-lr32e0w4 133 15 - - JJ cord-333286-lr32e0w4 133 16 inflammatory inflammatory JJ cord-333286-lr32e0w4 133 17 cytokine cytokine NN cord-333286-lr32e0w4 133 18 release release NN cord-333286-lr32e0w4 133 19 in in IN cord-333286-lr32e0w4 133 20 the the DT cord-333286-lr32e0w4 133 21 lungs lung NNS cord-333286-lr32e0w4 133 22 before before RB cord-333286-lr32e0w4 133 23 and and CC cord-333286-lr32e0w4 133 24 after after IN cord-333286-lr32e0w4 133 25 influenza influenza NN cord-333286-lr32e0w4 133 26 infection infection NN cord-333286-lr32e0w4 133 27 and and CC cord-333286-lr32e0w4 133 28 affected affect VBN cord-333286-lr32e0w4 133 29 total total JJ cord-333286-lr32e0w4 133 30 cell cell NN cord-333286-lr32e0w4 133 31 counts count NNS cord-333286-lr32e0w4 133 32 in in IN cord-333286-lr32e0w4 133 33 the the DT cord-333286-lr32e0w4 133 34 lungs lung NNS cord-333286-lr32e0w4 133 35 after after IN cord-333286-lr32e0w4 133 36 probiotic probiotic JJ cord-333286-lr32e0w4 133 37 treatment treatment NN cord-333286-lr32e0w4 133 38 [ [ -LRB- cord-333286-lr32e0w4 133 39 74 74 CD cord-333286-lr32e0w4 133 40 ] ] -RRB- cord-333286-lr32e0w4 133 41 . . . cord-333286-lr32e0w4 134 1 Similarly similarly RB cord-333286-lr32e0w4 134 2 , , , cord-333286-lr32e0w4 134 3 B. B. NNP cord-333286-lr32e0w4 134 4 longum longum NNP cord-333286-lr32e0w4 134 5 MM-2 MM-2 NNP cord-333286-lr32e0w4 134 6 suppressed suppress VBD cord-333286-lr32e0w4 134 7 inflammation inflammation NN cord-333286-lr32e0w4 134 8 in in IN cord-333286-lr32e0w4 134 9 the the DT cord-333286-lr32e0w4 134 10 lower low JJR cord-333286-lr32e0w4 134 11 respiratory respiratory JJ cord-333286-lr32e0w4 134 12 tract tract NN cord-333286-lr32e0w4 134 13 through through IN cord-333286-lr32e0w4 134 14 the the DT cord-333286-lr32e0w4 134 15 decrease decrease NN cord-333286-lr32e0w4 134 16 in in IN cord-333286-lr32e0w4 134 17 influenza influenza NN cord-333286-lr32e0w4 134 18 virus virus NN cord-333286-lr32e0w4 134 19 proliferation proliferation NN cord-333286-lr32e0w4 134 20 and and CC cord-333286-lr32e0w4 134 21 pulmonary pulmonary JJ cord-333286-lr32e0w4 134 22 IL-6 IL-6 NNP cord-333286-lr32e0w4 134 23 and and CC cord-333286-lr32e0w4 134 24 TNF TNF NNP cord-333286-lr32e0w4 134 25 - - HYPH cord-333286-lr32e0w4 134 26 α α NN cord-333286-lr32e0w4 134 27 cytokine cytokine NN cord-333286-lr32e0w4 134 28 production production NN cord-333286-lr32e0w4 134 29 [ [ -LRB- cord-333286-lr32e0w4 134 30 75 75 CD cord-333286-lr32e0w4 134 31 ] ] -RRB- cord-333286-lr32e0w4 134 32 . . . cord-333286-lr32e0w4 135 1 Activation activation NN cord-333286-lr32e0w4 135 2 of of IN cord-333286-lr32e0w4 135 3 host host NN cord-333286-lr32e0w4 135 4 defense defense NN cord-333286-lr32e0w4 135 5 systems system NNS cord-333286-lr32e0w4 135 6 by by IN cord-333286-lr32e0w4 135 7 increased increase VBN cord-333286-lr32e0w4 135 8 IFN IFN NNP cord-333286-lr32e0w4 135 9 - - HYPH cord-333286-lr32e0w4 135 10 γ γ NNP cord-333286-lr32e0w4 135 11 , , , cord-333286-lr32e0w4 135 12 IL-2 IL-2 NNP cord-333286-lr32e0w4 135 13 , , , cord-333286-lr32e0w4 135 14 IL-12 IL-12 NNP cord-333286-lr32e0w4 135 15 , , , cord-333286-lr32e0w4 135 16 and and CC cord-333286-lr32e0w4 135 17 IL-18 IL-18 NNP cord-333286-lr32e0w4 135 18 gene gene NN cord-333286-lr32e0w4 135 19 expression expression NN cord-333286-lr32e0w4 135 20 and and CC cord-333286-lr32e0w4 135 21 NK NK NNP cord-333286-lr32e0w4 135 22 cell cell NN cord-333286-lr32e0w4 135 23 activation activation NN cord-333286-lr32e0w4 135 24 in in IN cord-333286-lr32e0w4 135 25 lungs lung NNS cord-333286-lr32e0w4 135 26 was be VBD cord-333286-lr32e0w4 135 27 also also RB cord-333286-lr32e0w4 135 28 demonstrated demonstrate VBN cord-333286-lr32e0w4 135 29 . . . cord-333286-lr32e0w4 136 1 In in IN cord-333286-lr32e0w4 136 2 non non JJ cord-333286-lr32e0w4 136 3 - - JJ cord-333286-lr32e0w4 136 4 infected infected JJ cord-333286-lr32e0w4 136 5 mice mouse NNS cord-333286-lr32e0w4 136 6 , , , cord-333286-lr32e0w4 136 7 B. B. NNP cord-333286-lr32e0w4 136 8 longum longum NNP cord-333286-lr32e0w4 136 9 MM-2 MM-2 NNP cord-333286-lr32e0w4 136 10 significantly significantly RB cord-333286-lr32e0w4 136 11 enhanced enhance VBD cord-333286-lr32e0w4 136 12 IFN IFN NNP cord-333286-lr32e0w4 136 13 - - HYPH cord-333286-lr32e0w4 136 14 γ γ NN cord-333286-lr32e0w4 136 15 production production NN cord-333286-lr32e0w4 136 16 by by IN cord-333286-lr32e0w4 136 17 Peyer Peyer NNP cord-333286-lr32e0w4 136 18 's 's POS cord-333286-lr32e0w4 136 19 patch patch NN cord-333286-lr32e0w4 136 20 cells cell NNS cord-333286-lr32e0w4 136 21 and and CC cord-333286-lr32e0w4 136 22 splenic splenic JJ cord-333286-lr32e0w4 136 23 NK nk NN cord-333286-lr32e0w4 136 24 cell cell NN cord-333286-lr32e0w4 136 25 activity activity NN cord-333286-lr32e0w4 136 26 . . . cord-333286-lr32e0w4 137 1 In in IN cord-333286-lr32e0w4 137 2 the the DT cord-333286-lr32e0w4 137 3 infected infected JJ cord-333286-lr32e0w4 137 4 mice mouse NNS cord-333286-lr32e0w4 137 5 , , , cord-333286-lr32e0w4 137 6 NK NK NNP cord-333286-lr32e0w4 137 7 cell cell NN cord-333286-lr32e0w4 137 8 activity activity NN cord-333286-lr32e0w4 137 9 was be VBD cord-333286-lr32e0w4 137 10 significantly significantly RB cord-333286-lr32e0w4 137 11 enhanced enhance VBN cord-333286-lr32e0w4 137 12 both both CC cord-333286-lr32e0w4 137 13 in in IN cord-333286-lr32e0w4 137 14 the the DT cord-333286-lr32e0w4 137 15 spleen spleen NN cord-333286-lr32e0w4 137 16 and and CC cord-333286-lr32e0w4 137 17 lungs lung NNS cord-333286-lr32e0w4 137 18 by by IN cord-333286-lr32e0w4 137 19 the the DT cord-333286-lr32e0w4 137 20 probiotic probiotic JJ cord-333286-lr32e0w4 137 21 strain strain NN cord-333286-lr32e0w4 137 22 . . . cord-333286-lr32e0w4 138 1 Another another DT cord-333286-lr32e0w4 138 2 Bifidobacterium bifidobacterium NN cord-333286-lr32e0w4 138 3 ( ( -LRB- cord-333286-lr32e0w4 138 4 B. B. NNP cord-333286-lr32e0w4 138 5 bifidum bifidum NNP cord-333286-lr32e0w4 138 6 ) ) -RRB- cord-333286-lr32e0w4 138 7 improved improve VBN cord-333286-lr32e0w4 138 8 anti anti JJ cord-333286-lr32e0w4 138 9 - - JJ cord-333286-lr32e0w4 138 10 influenza influenza JJ cord-333286-lr32e0w4 138 11 immune immune JJ cord-333286-lr32e0w4 138 12 responses response NNS cord-333286-lr32e0w4 138 13 by by IN cord-333286-lr32e0w4 138 14 inducing induce VBG cord-333286-lr32e0w4 138 15 both both DT cord-333286-lr32e0w4 138 16 humoral humoral JJ cord-333286-lr32e0w4 138 17 and and CC cord-333286-lr32e0w4 138 18 cellular cellular JJ cord-333286-lr32e0w4 138 19 immunities immunity NNS cord-333286-lr32e0w4 138 20 [ [ -LRB- cord-333286-lr32e0w4 138 21 76 76 CD cord-333286-lr32e0w4 138 22 ] ] -RRB- cord-333286-lr32e0w4 138 23 . . . cord-333286-lr32e0w4 139 1 Decreased decrease VBD cord-333286-lr32e0w4 139 2 IL-6 IL-6 NNP cord-333286-lr32e0w4 139 3 levels level NNS cord-333286-lr32e0w4 139 4 were be VBD cord-333286-lr32e0w4 139 5 detected detect VBN cord-333286-lr32e0w4 139 6 in in IN cord-333286-lr32e0w4 139 7 the the DT cord-333286-lr32e0w4 139 8 lung lung NN cord-333286-lr32e0w4 139 9 and and CC cord-333286-lr32e0w4 139 10 higher high JJR cord-333286-lr32e0w4 139 11 IgG1 igg1 NN cord-333286-lr32e0w4 139 12 and and CC cord-333286-lr32e0w4 139 13 IgG2 igg2 JJ cord-333286-lr32e0w4 139 14 levels level NNS cord-333286-lr32e0w4 139 15 in in IN cord-333286-lr32e0w4 139 16 the the DT cord-333286-lr32e0w4 139 17 sera sera NNP cord-333286-lr32e0w4 139 18 of of IN cord-333286-lr32e0w4 139 19 probiotic probiotic NN cord-333286-lr32e0w4 139 20 - - HYPH cord-333286-lr32e0w4 139 21 treated treat VBN cord-333286-lr32e0w4 139 22 mice mouse NNS cord-333286-lr32e0w4 139 23 compared compare VBN cord-333286-lr32e0w4 139 24 with with IN cord-333286-lr32e0w4 139 25 control control NN cord-333286-lr32e0w4 139 26 mice mouse NNS cord-333286-lr32e0w4 139 27 . . . cord-333286-lr32e0w4 140 1 Furthermore furthermore RB cord-333286-lr32e0w4 140 2 , , , cord-333286-lr32e0w4 140 3 L. L. NNP cord-333286-lr32e0w4 140 4 gasseri gasseri NNP cord-333286-lr32e0w4 140 5 SBT2055 SBT2055 NNP cord-333286-lr32e0w4 140 6 has have VBZ cord-333286-lr32e0w4 140 7 been be VBN cord-333286-lr32e0w4 140 8 found find VBN cord-333286-lr32e0w4 140 9 effective effective JJ cord-333286-lr32e0w4 140 10 in in IN cord-333286-lr32e0w4 140 11 preventing prevent VBG cord-333286-lr32e0w4 140 12 both both DT cord-333286-lr32e0w4 140 13 influenza influenza NN cord-333286-lr32e0w4 140 14 A a DT cord-333286-lr32e0w4 140 15 virus virus NN cord-333286-lr32e0w4 140 16 [ [ -LRB- cord-333286-lr32e0w4 140 17 60 60 CD cord-333286-lr32e0w4 140 18 ] ] -RRB- cord-333286-lr32e0w4 140 19 and and CC cord-333286-lr32e0w4 140 20 RSV RSV NNP cord-333286-lr32e0w4 140 21 [ [ -LRB- cord-333286-lr32e0w4 140 22 78 78 CD cord-333286-lr32e0w4 140 23 ] ] -RRB- cord-333286-lr32e0w4 140 24 infections infection NNS cord-333286-lr32e0w4 140 25 in in IN cord-333286-lr32e0w4 140 26 mice mouse NNS cord-333286-lr32e0w4 140 27 . . . cord-333286-lr32e0w4 141 1 Pre pre JJ cord-333286-lr32e0w4 141 2 - - NN cord-333286-lr32e0w4 141 3 treatment treatment NN cord-333286-lr32e0w4 141 4 with with IN cord-333286-lr32e0w4 141 5 L. L. NNP cord-333286-lr32e0w4 141 6 gasseri gasseri NNP cord-333286-lr32e0w4 142 1 SBT2055 SBT2055 NNP cord-333286-lr32e0w4 142 2 induced induce VBD cord-333286-lr32e0w4 142 3 the the DT cord-333286-lr32e0w4 142 4 expression expression NN cord-333286-lr32e0w4 142 5 of of IN cord-333286-lr32e0w4 142 6 antiviral antiviral JJ cord-333286-lr32e0w4 142 7 genes gene NNS cord-333286-lr32e0w4 142 8 Mx1 mx1 JJ cord-333286-lr32e0w4 142 9 and and CC cord-333286-lr32e0w4 142 10 2 2 CD cord-333286-lr32e0w4 142 11 -5 -5 CD cord-333286-lr32e0w4 142 12 oligoadenylate oligoadenylate NNP cord-333286-lr32e0w4 142 13 synthase synthase NN cord-333286-lr32e0w4 143 1 ( ( -LRB- cord-333286-lr32e0w4 143 2 OAS)1a OAS)1a NNP cord-333286-lr32e0w4 143 3 in in IN cord-333286-lr32e0w4 143 4 lung lung NN cord-333286-lr32e0w4 143 5 tissues tissue NNS cord-333286-lr32e0w4 143 6 before before IN cord-333286-lr32e0w4 143 7 viral viral JJ cord-333286-lr32e0w4 143 8 infection infection NN cord-333286-lr32e0w4 143 9 and and CC cord-333286-lr32e0w4 143 10 reduced reduce VBN cord-333286-lr32e0w4 143 11 lung lung NN cord-333286-lr32e0w4 143 12 inflammatory inflammatory JJ cord-333286-lr32e0w4 143 13 responses response NNS cord-333286-lr32e0w4 143 14 after after IN cord-333286-lr32e0w4 143 15 viral viral JJ cord-333286-lr32e0w4 143 16 infection infection NN cord-333286-lr32e0w4 143 17 [ [ -LRB- cord-333286-lr32e0w4 143 18 60 60 CD cord-333286-lr32e0w4 143 19 ] ] -RRB- cord-333286-lr32e0w4 143 20 . . . cord-333286-lr32e0w4 144 1 The the DT cord-333286-lr32e0w4 144 2 same same JJ cord-333286-lr32e0w4 144 3 L. L. NNP cord-333286-lr32e0w4 144 4 gasseri gasseri NNP cord-333286-lr32e0w4 144 5 strain strain NN cord-333286-lr32e0w4 144 6 was be VBD cord-333286-lr32e0w4 144 7 found find VBN cord-333286-lr32e0w4 144 8 effective effective JJ cord-333286-lr32e0w4 144 9 in in IN cord-333286-lr32e0w4 144 10 preventing prevent VBG cord-333286-lr32e0w4 144 11 RSV RSV NNP cord-333286-lr32e0w4 144 12 infection infection NN cord-333286-lr32e0w4 144 13 in in IN cord-333286-lr32e0w4 144 14 mice mouse NNS cord-333286-lr32e0w4 144 15 by by IN cord-333286-lr32e0w4 144 16 reducing reduce VBG cord-333286-lr32e0w4 144 17 lung lung NN cord-333286-lr32e0w4 144 18 viral viral JJ cord-333286-lr32e0w4 144 19 loads load NNS cord-333286-lr32e0w4 144 20 and and CC cord-333286-lr32e0w4 144 21 pro pro JJ cord-333286-lr32e0w4 144 22 - - JJ cord-333286-lr32e0w4 144 23 inflammatory inflammatory JJ cord-333286-lr32e0w4 144 24 cytokines cytokine NNS cord-333286-lr32e0w4 144 25 and and CC cord-333286-lr32e0w4 144 26 by by IN cord-333286-lr32e0w4 144 27 stimulating stimulate VBG cord-333286-lr32e0w4 144 28 IFNs ifn NNS cord-333286-lr32e0w4 144 29 and and CC cord-333286-lr32e0w4 144 30 IFN IFN NNP cord-333286-lr32e0w4 144 31 responsive responsive JJ cord-333286-lr32e0w4 144 32 gene gene NN cord-333286-lr32e0w4 144 33 expression expression NN cord-333286-lr32e0w4 144 34 such such JJ cord-333286-lr32e0w4 144 35 as as IN cord-333286-lr32e0w4 144 36 IFN IFN NNP cord-333286-lr32e0w4 144 37 - - HYPH cord-333286-lr32e0w4 144 38 β1 β1 NNP cord-333286-lr32e0w4 144 39 , , , cord-333286-lr32e0w4 144 40 IFN IFN NNP cord-333286-lr32e0w4 144 41 - - HYPH cord-333286-lr32e0w4 144 42 γ γ NNP cord-333286-lr32e0w4 144 43 , , , cord-333286-lr32e0w4 144 44 interferon interferon NN cord-333286-lr32e0w4 144 45 - - HYPH cord-333286-lr32e0w4 144 46 inducible inducible JJ cord-333286-lr32e0w4 144 47 transmembrane transmembrane NN cord-333286-lr32e0w4 144 48 protein protein NN cord-333286-lr32e0w4 144 49 ( ( -LRB- cord-333286-lr32e0w4 144 50 IFITM)3 IFITM)3 NNP cord-333286-lr32e0w4 144 51 , , , cord-333286-lr32e0w4 144 52 OAS1a OAS1a NNP cord-333286-lr32e0w4 144 53 , , , cord-333286-lr32e0w4 144 54 and and CC cord-333286-lr32e0w4 144 55 interferon interferon NN cord-333286-lr32e0w4 144 56 - - HYPH cord-333286-lr32e0w4 144 57 stimulated stimulate VBN cord-333286-lr32e0w4 144 58 gene gene NN cord-333286-lr32e0w4 144 59 ( ( -LRB- cord-333286-lr32e0w4 144 60 ISG)15 ISG)15 NNP cord-333286-lr32e0w4 144 61 [ [ -LRB- cord-333286-lr32e0w4 144 62 78 78 CD cord-333286-lr32e0w4 144 63 ] ] -RRB- cord-333286-lr32e0w4 144 64 . . . cord-333286-lr32e0w4 145 1 In in IN cord-333286-lr32e0w4 145 2 addition addition NN cord-333286-lr32e0w4 145 3 to to TO cord-333286-lr32e0w4 145 4 live live VB cord-333286-lr32e0w4 145 5 probiotics probiotic NNS cord-333286-lr32e0w4 145 6 , , , cord-333286-lr32e0w4 145 7 also also RB cord-333286-lr32e0w4 145 8 orally orally RB cord-333286-lr32e0w4 145 9 administered administer VBN cord-333286-lr32e0w4 145 10 heat heat NN cord-333286-lr32e0w4 145 11 - - HYPH cord-333286-lr32e0w4 145 12 killed kill VBN cord-333286-lr32e0w4 145 13 bacteria bacteria NNS cord-333286-lr32e0w4 145 14 seem seem VBP cord-333286-lr32e0w4 145 15 to to TO cord-333286-lr32e0w4 145 16 confer confer VB cord-333286-lr32e0w4 145 17 protection protection NN cord-333286-lr32e0w4 145 18 against against IN cord-333286-lr32e0w4 145 19 viral viral JJ cord-333286-lr32e0w4 145 20 RTIs rti NNS cord-333286-lr32e0w4 145 21 in in IN cord-333286-lr32e0w4 145 22 mice mouse NNS cord-333286-lr32e0w4 145 23 [ [ -LRB- cord-333286-lr32e0w4 145 24 73 73 CD cord-333286-lr32e0w4 145 25 ] ] -RRB- cord-333286-lr32e0w4 145 26 . . . cord-333286-lr32e0w4 146 1 Heat heat NN cord-333286-lr32e0w4 146 2 - - HYPH cord-333286-lr32e0w4 146 3 killed kill VBN cord-333286-lr32e0w4 146 4 L. L. NNP cord-333286-lr32e0w4 146 5 paracasei paracasei NNP cord-333286-lr32e0w4 146 6 MCC1849 MCC1849 NNP cord-333286-lr32e0w4 146 7 reduced reduce VBN cord-333286-lr32e0w4 146 8 symptom symptom NN cord-333286-lr32e0w4 146 9 scores score NNS cord-333286-lr32e0w4 146 10 and and CC cord-333286-lr32e0w4 146 11 lung lung NN cord-333286-lr32e0w4 146 12 virus virus NN cord-333286-lr32e0w4 146 13 titers titer NNS cord-333286-lr32e0w4 146 14 in in IN cord-333286-lr32e0w4 146 15 influenza influenza NN cord-333286-lr32e0w4 146 16 - - HYPH cord-333286-lr32e0w4 146 17 infected infect VBN cord-333286-lr32e0w4 146 18 mice mouse NNS cord-333286-lr32e0w4 146 19 and and CC cord-333286-lr32e0w4 146 20 induced induce VBN cord-333286-lr32e0w4 146 21 antigen antigen NN cord-333286-lr32e0w4 146 22 - - HYPH cord-333286-lr32e0w4 146 23 specific specific JJ cord-333286-lr32e0w4 146 24 IgA IgA NNP cord-333286-lr32e0w4 146 25 production production NN cord-333286-lr32e0w4 146 26 in in IN cord-333286-lr32e0w4 146 27 the the DT cord-333286-lr32e0w4 146 28 small small JJ cord-333286-lr32e0w4 146 29 intestine intestine NN cord-333286-lr32e0w4 146 30 , , , cord-333286-lr32e0w4 146 31 serum serum NN cord-333286-lr32e0w4 146 32 , , , cord-333286-lr32e0w4 146 33 and and CC cord-333286-lr32e0w4 146 34 lungs lung NNS cord-333286-lr32e0w4 146 35 . . . cord-333286-lr32e0w4 147 1 The the DT cord-333286-lr32e0w4 147 2 proportion proportion NN cord-333286-lr32e0w4 147 3 of of IN cord-333286-lr32e0w4 147 4 IgA+ IgA+ NNPS cord-333286-lr32e0w4 147 5 B b NN cord-333286-lr32e0w4 147 6 cells cell NNS cord-333286-lr32e0w4 147 7 and and CC cord-333286-lr32e0w4 147 8 follicular follicular JJ cord-333286-lr32e0w4 147 9 helper helper NN cord-333286-lr32e0w4 147 10 T t NN cord-333286-lr32e0w4 147 11 cells cell NNS cord-333286-lr32e0w4 147 12 ( ( -LRB- cord-333286-lr32e0w4 147 13 Tfh Tfh NNP cord-333286-lr32e0w4 147 14 ) ) -RRB- cord-333286-lr32e0w4 147 15 in in IN cord-333286-lr32e0w4 147 16 Peyer Peyer NNP cord-333286-lr32e0w4 147 17 's 's POS cord-333286-lr32e0w4 147 18 patches patch NNS cord-333286-lr32e0w4 147 19 was be VBD cord-333286-lr32e0w4 147 20 increased increase VBN cord-333286-lr32e0w4 147 21 as as IN cord-333286-lr32e0w4 147 22 was be VBD cord-333286-lr32e0w4 147 23 the the DT cord-333286-lr32e0w4 147 24 gene gene NN cord-333286-lr32e0w4 147 25 expression expression NN cord-333286-lr32e0w4 147 26 of of IN cord-333286-lr32e0w4 147 27 IL-12p40 IL-12p40 NNP cord-333286-lr32e0w4 147 28 , , , cord-333286-lr32e0w4 147 29 IL-10 IL-10 NNP cord-333286-lr32e0w4 147 30 , , , cord-333286-lr32e0w4 147 31 IL-21 IL-21 NNP cord-333286-lr32e0w4 147 32 , , , cord-333286-lr32e0w4 147 33 signal signal NN cord-333286-lr32e0w4 147 34 transducer transducer NN cord-333286-lr32e0w4 147 35 and and CC cord-333286-lr32e0w4 147 36 activator activator NN cord-333286-lr32e0w4 147 37 of of IN cord-333286-lr32e0w4 147 38 transcription transcription NN cord-333286-lr32e0w4 147 39 ( ( -LRB- cord-333286-lr32e0w4 147 40 STAT)4 STAT)4 NNP cord-333286-lr32e0w4 147 41 , , , cord-333286-lr32e0w4 147 42 and and CC cord-333286-lr32e0w4 147 43 B B NNP cord-333286-lr32e0w4 147 44 cell cell NN cord-333286-lr32e0w4 147 45 lymphoma lymphoma NN cord-333286-lr32e0w4 147 46 protein protein NN cord-333286-lr32e0w4 147 47 ( ( -LRB- cord-333286-lr32e0w4 147 48 Bcl)-6 Bcl)-6 NNP cord-333286-lr32e0w4 147 49 , , , cord-333286-lr32e0w4 147 50 which which WDT cord-333286-lr32e0w4 147 51 are be VBP cord-333286-lr32e0w4 147 52 associated associate VBN cord-333286-lr32e0w4 147 53 with with IN cord-333286-lr32e0w4 147 54 Tfh Tfh NNP cord-333286-lr32e0w4 147 55 cell cell NN cord-333286-lr32e0w4 147 56 differentiation differentiation NN cord-333286-lr32e0w4 147 57 . . . cord-333286-lr32e0w4 148 1 To to TO cord-333286-lr32e0w4 148 2 conclude conclude VB cord-333286-lr32e0w4 148 3 , , , cord-333286-lr32e0w4 148 4 different different JJ cord-333286-lr32e0w4 148 5 probiotic probiotic JJ cord-333286-lr32e0w4 148 6 strains strain NNS cord-333286-lr32e0w4 148 7 have have VBP cord-333286-lr32e0w4 148 8 been be VBN cord-333286-lr32e0w4 148 9 shown show VBN cord-333286-lr32e0w4 148 10 effective effective JJ cord-333286-lr32e0w4 148 11 in in IN cord-333286-lr32e0w4 148 12 inhibiting inhibit VBG cord-333286-lr32e0w4 148 13 the the DT cord-333286-lr32e0w4 148 14 replication replication NN cord-333286-lr32e0w4 148 15 of of IN cord-333286-lr32e0w4 148 16 various various JJ cord-333286-lr32e0w4 148 17 respiratory respiratory JJ cord-333286-lr32e0w4 148 18 viruses virus NNS cord-333286-lr32e0w4 148 19 including include VBG cord-333286-lr32e0w4 148 20 influenza influenza NN cord-333286-lr32e0w4 148 21 viruses virus NNS cord-333286-lr32e0w4 148 22 and and CC cord-333286-lr32e0w4 148 23 RSV RSV NNP cord-333286-lr32e0w4 148 24 in in IN cord-333286-lr32e0w4 148 25 vitro vitro FW cord-333286-lr32e0w4 148 26 . . . cord-333286-lr32e0w4 149 1 Similar similar JJ cord-333286-lr32e0w4 149 2 effects effect NNS cord-333286-lr32e0w4 149 3 have have VBP cord-333286-lr32e0w4 149 4 been be VBN cord-333286-lr32e0w4 149 5 demonstrated demonstrate VBN cord-333286-lr32e0w4 149 6 in in IN cord-333286-lr32e0w4 149 7 several several JJ cord-333286-lr32e0w4 149 8 mouse mouse NN cord-333286-lr32e0w4 149 9 studies study NNS cord-333286-lr32e0w4 149 10 with with IN cord-333286-lr32e0w4 149 11 the the DT cord-333286-lr32e0w4 149 12 ability ability NN cord-333286-lr32e0w4 149 13 to to TO cord-333286-lr32e0w4 149 14 reduce reduce VB cord-333286-lr32e0w4 149 15 virus virus NN cord-333286-lr32e0w4 149 16 titers titer NNS cord-333286-lr32e0w4 149 17 in in IN cord-333286-lr32e0w4 149 18 lung lung NN cord-333286-lr32e0w4 149 19 tissues tissue NNS cord-333286-lr32e0w4 149 20 and and CC cord-333286-lr32e0w4 149 21 modulation modulation NN cord-333286-lr32e0w4 149 22 of of IN cord-333286-lr32e0w4 149 23 antiviral antiviral JJ cord-333286-lr32e0w4 149 24 and and CC cord-333286-lr32e0w4 149 25 pro pro JJ cord-333286-lr32e0w4 149 26 - - JJ cord-333286-lr32e0w4 149 27 inflammatory inflammatory JJ cord-333286-lr32e0w4 149 28 gene gene NN cord-333286-lr32e0w4 149 29 expression expression NN cord-333286-lr32e0w4 149 30 before before IN cord-333286-lr32e0w4 149 31 and and CC cord-333286-lr32e0w4 149 32 after after IN cord-333286-lr32e0w4 149 33 viral viral JJ cord-333286-lr32e0w4 149 34 infection infection NN cord-333286-lr32e0w4 149 35 . . . cord-333286-lr32e0w4 150 1 Accumulating accumulate VBG cord-333286-lr32e0w4 150 2 clinical clinical JJ cord-333286-lr32e0w4 150 3 evidence evidence NN cord-333286-lr32e0w4 150 4 suggests suggest VBZ cord-333286-lr32e0w4 150 5 that that IN cord-333286-lr32e0w4 150 6 probiotics probiotic NNS cord-333286-lr32e0w4 150 7 in in IN cord-333286-lr32e0w4 150 8 general general JJ cord-333286-lr32e0w4 150 9 may may MD cord-333286-lr32e0w4 150 10 have have VB cord-333286-lr32e0w4 150 11 favorable favorable JJ cord-333286-lr32e0w4 150 12 effects effect NNS cord-333286-lr32e0w4 150 13 against against IN cord-333286-lr32e0w4 150 14 RTIs rti NNS cord-333286-lr32e0w4 150 15 . . . cord-333286-lr32e0w4 151 1 For for IN cord-333286-lr32e0w4 151 2 instance instance NN cord-333286-lr32e0w4 151 3 , , , cord-333286-lr32e0w4 151 4 several several JJ cord-333286-lr32e0w4 151 5 systematic systematic JJ cord-333286-lr32e0w4 151 6 reviews review NNS cord-333286-lr32e0w4 151 7 and/or and/or CC cord-333286-lr32e0w4 151 8 meta meta NNP cord-333286-lr32e0w4 151 9 - - HYPH cord-333286-lr32e0w4 151 10 analyses analysis NNS cord-333286-lr32e0w4 151 11 have have VBP cord-333286-lr32e0w4 151 12 evaluated evaluate VBN cord-333286-lr32e0w4 151 13 the the DT cord-333286-lr32e0w4 151 14 effects effect NNS cord-333286-lr32e0w4 151 15 of of IN cord-333286-lr32e0w4 151 16 prophylactic prophylactic JJ cord-333286-lr32e0w4 151 17 ingestion ingestion NN cord-333286-lr32e0w4 151 18 of of IN cord-333286-lr32e0w4 151 19 probiotics probiotic NNS cord-333286-lr32e0w4 151 20 on on IN cord-333286-lr32e0w4 151 21 the the DT cord-333286-lr32e0w4 151 22 RTI RTI NNP cord-333286-lr32e0w4 151 23 - - HYPH cord-333286-lr32e0w4 151 24 associated associate VBN cord-333286-lr32e0w4 151 25 outcomes outcome NNS cord-333286-lr32e0w4 151 26 , , , cord-333286-lr32e0w4 151 27 e.g. e.g. RB cord-333286-lr32e0w4 151 28 , , , cord-333286-lr32e0w4 151 29 either either CC cord-333286-lr32e0w4 151 30 only only RB cord-333286-lr32e0w4 151 31 in in IN cord-333286-lr32e0w4 151 32 children child NNS cord-333286-lr32e0w4 151 33 [ [ -LRB- cord-333286-lr32e0w4 151 34 79 79 CD cord-333286-lr32e0w4 151 35 , , , cord-333286-lr32e0w4 151 36 80 80 CD cord-333286-lr32e0w4 151 37 ] ] -RRB- cord-333286-lr32e0w4 151 38 , , , cord-333286-lr32e0w4 151 39 or or CC cord-333286-lr32e0w4 151 40 both both DT cord-333286-lr32e0w4 151 41 in in IN cord-333286-lr32e0w4 151 42 children child NNS cord-333286-lr32e0w4 151 43 and and CC cord-333286-lr32e0w4 151 44 adults adult NNS cord-333286-lr32e0w4 151 45 [ [ -LRB- cord-333286-lr32e0w4 151 46 5 5 CD cord-333286-lr32e0w4 151 47 , , , cord-333286-lr32e0w4 151 48 6 6 CD cord-333286-lr32e0w4 151 49 , , , cord-333286-lr32e0w4 151 50 45 45 CD cord-333286-lr32e0w4 151 51 ] ] -RRB- cord-333286-lr32e0w4 151 52 ( ( -LRB- cord-333286-lr32e0w4 151 53 Table table NN cord-333286-lr32e0w4 151 54 1 1 CD cord-333286-lr32e0w4 151 55 ) ) -RRB- cord-333286-lr32e0w4 151 56 . . . cord-333286-lr32e0w4 152 1 Of of IN cord-333286-lr32e0w4 152 2 note note NN cord-333286-lr32e0w4 152 3 , , , cord-333286-lr32e0w4 152 4 the the DT cord-333286-lr32e0w4 152 5 majority majority NN cord-333286-lr32e0w4 152 6 of of IN cord-333286-lr32e0w4 152 7 the the DT cord-333286-lr32e0w4 152 8 outcomes outcome NNS cord-333286-lr32e0w4 152 9 in in IN cord-333286-lr32e0w4 152 10 these these DT cord-333286-lr32e0w4 152 11 analyses analysis NNS cord-333286-lr32e0w4 152 12 are be VBP cord-333286-lr32e0w4 152 13 related relate VBN cord-333286-lr32e0w4 152 14 to to IN cord-333286-lr32e0w4 152 15 URTI URTI NNP cord-333286-lr32e0w4 152 16 , , , cord-333286-lr32e0w4 152 17 and and CC cord-333286-lr32e0w4 152 18 data datum NNS cord-333286-lr32e0w4 152 19 on on IN cord-333286-lr32e0w4 152 20 LRTI LRTI NNP cord-333286-lr32e0w4 152 21 outcomes outcome NNS cord-333286-lr32e0w4 152 22 are be VBP cord-333286-lr32e0w4 152 23 either either CC cord-333286-lr32e0w4 152 24 not not RB cord-333286-lr32e0w4 152 25 available available JJ cord-333286-lr32e0w4 152 26 or or CC cord-333286-lr32e0w4 152 27 are be VBP cord-333286-lr32e0w4 152 28 very very RB cord-333286-lr32e0w4 152 29 limited limited JJ cord-333286-lr32e0w4 152 30 . . . cord-333286-lr32e0w4 153 1 Therefore therefore RB cord-333286-lr32e0w4 153 2 , , , cord-333286-lr32e0w4 153 3 in in IN cord-333286-lr32e0w4 153 4 the the DT cord-333286-lr32e0w4 153 5 below below JJ cord-333286-lr32e0w4 153 6 chapter chapter NN cord-333286-lr32e0w4 153 7 , , , cord-333286-lr32e0w4 153 8 we -PRON- PRP cord-333286-lr32e0w4 153 9 primarily primarily RB cord-333286-lr32e0w4 153 10 focus focus VBP cord-333286-lr32e0w4 153 11 on on IN cord-333286-lr32e0w4 153 12 clinical clinical JJ cord-333286-lr32e0w4 153 13 trials trial NNS cord-333286-lr32e0w4 153 14 on on IN cord-333286-lr32e0w4 153 15 probiotics probiotic NNS cord-333286-lr32e0w4 153 16 ' ' POS cord-333286-lr32e0w4 153 17 effects effect NNS cord-333286-lr32e0w4 153 18 on on IN cord-333286-lr32e0w4 153 19 URTI URTI NNP cord-333286-lr32e0w4 153 20 symptoms symptom NNS cord-333286-lr32e0w4 153 21 / / SYM cord-333286-lr32e0w4 153 22 episodes episode NNS cord-333286-lr32e0w4 153 23 / / SYM cord-333286-lr32e0w4 153 24 duration duration NN cord-333286-lr32e0w4 153 25 . . . cord-333286-lr32e0w4 154 1 Probiotic probiotic JJ cord-333286-lr32e0w4 154 2 consumption consumption NN cord-333286-lr32e0w4 154 3 had have VBD cord-333286-lr32e0w4 154 4 no no DT cord-333286-lr32e0w4 154 5 effect effect NN cord-333286-lr32e0w4 154 6 on on IN cord-333286-lr32e0w4 154 7 the the DT cord-333286-lr32e0w4 154 8 duration duration NN cord-333286-lr32e0w4 154 9 of of IN cord-333286-lr32e0w4 154 10 RTIs rti NNS cord-333286-lr32e0w4 154 11 ( ( -LRB- cord-333286-lr32e0w4 154 12 9 9 CD cord-333286-lr32e0w4 154 13 RCTs RCTs NNPS cord-333286-lr32e0w4 154 14 , , , cord-333286-lr32e0w4 154 15 n n NN cord-333286-lr32e0w4 154 16 = = SYM cord-333286-lr32e0w4 154 17 3529 3529 CD cord-333286-lr32e0w4 154 18 , , , cord-333286-lr32e0w4 154 19 MD MD NNP cord-333286-lr32e0w4 154 20 -0 -0 NNP cord-333286-lr32e0w4 154 21 . . . cord-333286-lr32e0w4 155 1 81 81 CD cord-333286-lr32e0w4 156 1 In in IN cord-333286-lr32e0w4 156 2 children child NNS cord-333286-lr32e0w4 156 3 ( ( -LRB- cord-333286-lr32e0w4 156 4 below below IN cord-333286-lr32e0w4 156 5 18 18 CD cord-333286-lr32e0w4 156 6 years year NNS cord-333286-lr32e0w4 156 7 ) ) -RRB- cord-333286-lr32e0w4 156 8 , , , cord-333286-lr32e0w4 156 9 the the DT cord-333286-lr32e0w4 156 10 meta meta NNP cord-333286-lr32e0w4 156 11 - - HYPH cord-333286-lr32e0w4 156 12 analysis analysis NN cord-333286-lr32e0w4 156 13 by by IN cord-333286-lr32e0w4 156 14 Wang Wang NNP cord-333286-lr32e0w4 156 15 et et NNP cord-333286-lr32e0w4 156 16 al al NNP cord-333286-lr32e0w4 156 17 . . NNP cord-333286-lr32e0w4 156 18 , , , cord-333286-lr32e0w4 156 19 2016 2016 CD cord-333286-lr32e0w4 156 20 , , , cord-333286-lr32e0w4 156 21 reported report VBD cord-333286-lr32e0w4 156 22 that that IN cord-333286-lr32e0w4 156 23 probiotic probiotic JJ cord-333286-lr32e0w4 156 24 use use NN cord-333286-lr32e0w4 156 25 compared compare VBN cord-333286-lr32e0w4 156 26 with with IN cord-333286-lr32e0w4 156 27 placebo placebo NN cord-333286-lr32e0w4 156 28 significantly significantly RB cord-333286-lr32e0w4 156 29 decreased decrease VBD cord-333286-lr32e0w4 156 30 the the DT cord-333286-lr32e0w4 156 31 number number NN cord-333286-lr32e0w4 156 32 of of IN cord-333286-lr32e0w4 156 33 subjects subject NNS cord-333286-lr32e0w4 156 34 having have VBG cord-333286-lr32e0w4 156 35 at at RB cord-333286-lr32e0w4 156 36 least least RBS cord-333286-lr32e0w4 156 37 one one CD cord-333286-lr32e0w4 156 38 RTI RTI NNP cord-333286-lr32e0w4 156 39 episode episode NN cord-333286-lr32e0w4 156 40 , , , cord-333286-lr32e0w4 156 41 had have VBD cord-333286-lr32e0w4 156 42 fewer few JJR cord-333286-lr32e0w4 156 43 numbers number NNS cord-333286-lr32e0w4 156 44 of of IN cord-333286-lr32e0w4 156 45 days day NNS cord-333286-lr32e0w4 156 46 of of IN cord-333286-lr32e0w4 156 47 RTIs rti NNS cord-333286-lr32e0w4 156 48 per per IN cord-333286-lr32e0w4 156 49 person person NN cord-333286-lr32e0w4 156 50 , , , cord-333286-lr32e0w4 156 51 and and CC cord-333286-lr32e0w4 156 52 had have VBD cord-333286-lr32e0w4 156 53 fewer few JJR cord-333286-lr32e0w4 156 54 numbers number NNS cord-333286-lr32e0w4 156 55 of of IN cord-333286-lr32e0w4 156 56 days day NNS cord-333286-lr32e0w4 156 57 absent absent JJ cord-333286-lr32e0w4 156 58 from from IN cord-333286-lr32e0w4 156 59 daycare daycare NN cord-333286-lr32e0w4 156 60 or or CC cord-333286-lr32e0w4 156 61 school school NN cord-333286-lr32e0w4 156 62 [ [ -LRB- cord-333286-lr32e0w4 156 63 80 80 CD cord-333286-lr32e0w4 156 64 ] ] -RRB- cord-333286-lr32e0w4 156 65 . . . cord-333286-lr32e0w4 157 1 However however RB cord-333286-lr32e0w4 157 2 , , , cord-333286-lr32e0w4 157 3 the the DT cord-333286-lr32e0w4 157 4 meta meta NNP cord-333286-lr32e0w4 157 5 - - HYPH cord-333286-lr32e0w4 157 6 analysis analysis NN cord-333286-lr32e0w4 157 7 did do VBD cord-333286-lr32e0w4 157 8 not not RB cord-333286-lr32e0w4 157 9 find find VB cord-333286-lr32e0w4 157 10 a a DT cord-333286-lr32e0w4 157 11 statistically statistically RB cord-333286-lr32e0w4 157 12 significant significant JJ cord-333286-lr32e0w4 157 13 difference difference NN cord-333286-lr32e0w4 157 14 on on IN cord-333286-lr32e0w4 157 15 the the DT cord-333286-lr32e0w4 157 16 illness illness NN cord-333286-lr32e0w4 157 17 episode episode NN cord-333286-lr32e0w4 157 18 duration duration NN cord-333286-lr32e0w4 157 19 between between IN cord-333286-lr32e0w4 157 20 the the DT cord-333286-lr32e0w4 157 21 probiotic probiotic NN cord-333286-lr32e0w4 157 22 and and CC cord-333286-lr32e0w4 157 23 the the DT cord-333286-lr32e0w4 157 24 placebo placebo NN cord-333286-lr32e0w4 157 25 . . . cord-333286-lr32e0w4 158 1 Laursen Laursen NNP cord-333286-lr32e0w4 158 2 and and CC cord-333286-lr32e0w4 158 3 Hojsak Hojsak NNP cord-333286-lr32e0w4 158 4 [ [ -LRB- cord-333286-lr32e0w4 158 5 79 79 CD cord-333286-lr32e0w4 158 6 ] ] -RRB- cord-333286-lr32e0w4 158 7 limited limit VBD cord-333286-lr32e0w4 158 8 the the DT cord-333286-lr32e0w4 158 9 analysis analysis NN cord-333286-lr32e0w4 158 10 to to IN cord-333286-lr32e0w4 158 11 children child NNS cord-333286-lr32e0w4 158 12 up up IN cord-333286-lr32e0w4 158 13 to to TO cord-333286-lr32e0w4 158 14 7 7 CD cord-333286-lr32e0w4 158 15 years year NNS cord-333286-lr32e0w4 158 16 old old JJ cord-333286-lr32e0w4 158 17 and and CC cord-333286-lr32e0w4 158 18 reported report VBD cord-333286-lr32e0w4 158 19 that that IN cord-333286-lr32e0w4 158 20 probiotic probiotic JJ cord-333286-lr32e0w4 158 21 use use NN cord-333286-lr32e0w4 158 22 was be VBD cord-333286-lr32e0w4 158 23 associated associate VBN cord-333286-lr32e0w4 158 24 with with IN cord-333286-lr32e0w4 158 25 reduced reduced JJ cord-333286-lr32e0w4 158 26 risk risk NN cord-333286-lr32e0w4 158 27 of of IN cord-333286-lr32e0w4 158 28 at at RB cord-333286-lr32e0w4 158 29 least least RBS cord-333286-lr32e0w4 158 30 one one CD cord-333286-lr32e0w4 158 31 URTI URTI NNP cord-333286-lr32e0w4 158 32 and and CC cord-333286-lr32e0w4 158 33 reduced reduce VBD cord-333286-lr32e0w4 158 34 the the DT cord-333286-lr32e0w4 158 35 risk risk NN cord-333286-lr32e0w4 158 36 of of IN cord-333286-lr32e0w4 158 37 antibiotic antibiotic JJ cord-333286-lr32e0w4 158 38 use use NN cord-333286-lr32e0w4 158 39 , , , cord-333286-lr32e0w4 158 40 but but CC cord-333286-lr32e0w4 158 41 the the DT cord-333286-lr32e0w4 158 42 use use NN cord-333286-lr32e0w4 158 43 was be VBD cord-333286-lr32e0w4 158 44 not not RB cord-333286-lr32e0w4 158 45 associated associate VBN cord-333286-lr32e0w4 158 46 with with IN cord-333286-lr32e0w4 158 47 a a DT cord-333286-lr32e0w4 158 48 reduction reduction NN cord-333286-lr32e0w4 158 49 in in IN cord-333286-lr32e0w4 158 50 RTI RTI NNP cord-333286-lr32e0w4 158 51 duration duration NN cord-333286-lr32e0w4 158 52 or or CC cord-333286-lr32e0w4 158 53 missed miss VBN cord-333286-lr32e0w4 158 54 days day NNS cord-333286-lr32e0w4 158 55 of of IN cord-333286-lr32e0w4 158 56 daycare daycare NN cord-333286-lr32e0w4 158 57 due due IN cord-333286-lr32e0w4 158 58 to to IN cord-333286-lr32e0w4 158 59 RTI RTI NNP cord-333286-lr32e0w4 158 60 [ [ -LRB- cord-333286-lr32e0w4 158 61 79 79 CD cord-333286-lr32e0w4 158 62 ] ] -RRB- cord-333286-lr32e0w4 158 63 . . . cord-333286-lr32e0w4 159 1 This this DT cord-333286-lr32e0w4 159 2 meta meta JJ cord-333286-lr32e0w4 159 3 - - HYPH cord-333286-lr32e0w4 159 4 analysis analysis NN cord-333286-lr32e0w4 159 5 also also RB cord-333286-lr32e0w4 159 6 discussed discuss VBD cord-333286-lr32e0w4 159 7 the the DT cord-333286-lr32e0w4 159 8 effects effect NNS cord-333286-lr32e0w4 159 9 of of IN cord-333286-lr32e0w4 159 10 the the DT cord-333286-lr32e0w4 159 11 individual individual JJ cord-333286-lr32e0w4 159 12 probiotic probiotic JJ cord-333286-lr32e0w4 159 13 strains strain NNS cord-333286-lr32e0w4 159 14 on on IN cord-333286-lr32e0w4 159 15 RTI RTI NNP cord-333286-lr32e0w4 159 16 outcomes outcome NNS cord-333286-lr32e0w4 159 17 . . . cord-333286-lr32e0w4 160 1 The the DT cord-333286-lr32e0w4 160 2 results result NNS cord-333286-lr32e0w4 160 3 of of IN cord-333286-lr32e0w4 160 4 the the DT cord-333286-lr32e0w4 160 5 analysis analysis NN cord-333286-lr32e0w4 160 6 showed show VBD cord-333286-lr32e0w4 160 7 that that IN cord-333286-lr32e0w4 160 8 the the DT cord-333286-lr32e0w4 160 9 most most RBS cord-333286-lr32e0w4 160 10 effective effective JJ cord-333286-lr32e0w4 160 11 probiotic probiotic JJ cord-333286-lr32e0w4 160 12 strains strain NNS cord-333286-lr32e0w4 160 13 on on IN cord-333286-lr32e0w4 160 14 RTI RTI NNP cord-333286-lr32e0w4 160 15 - - HYPH cord-333286-lr32e0w4 160 16 related relate VBN cord-333286-lr32e0w4 160 17 outcomes outcome NNS cord-333286-lr32e0w4 160 18 were be VBD cord-333286-lr32e0w4 160 19 L. L. NNP cord-333286-lr32e0w4 160 20 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 160 21 GG GG NNP cord-333286-lr32e0w4 160 22 ( ( -LRB- cord-333286-lr32e0w4 160 23 RTI RTI NNP cord-333286-lr32e0w4 160 24 duration duration NN cord-333286-lr32e0w4 160 25 ) ) -RRB- cord-333286-lr32e0w4 160 26 and and CC cord-333286-lr32e0w4 160 27 L. L. NNP cord-333286-lr32e0w4 160 28 acidophilus acidophilus NN cord-333286-lr32e0w4 160 29 NCFM NCFM NNP cord-333286-lr32e0w4 160 30 as as IN cord-333286-lr32e0w4 160 31 a a DT cord-333286-lr32e0w4 160 32 single single JJ cord-333286-lr32e0w4 160 33 supplement supplement NN cord-333286-lr32e0w4 160 34 and and CC cord-333286-lr32e0w4 160 35 in in IN cord-333286-lr32e0w4 160 36 combination combination NN cord-333286-lr32e0w4 160 37 with with IN cord-333286-lr32e0w4 160 38 B. B. NNP cord-333286-lr32e0w4 160 39 lactis lactis NNP cord-333286-lr32e0w4 161 1 Bi-07 Bi-07 . cord-333286-lr32e0w4 162 1 ( ( -LRB- cord-333286-lr32e0w4 162 2 RTI RTI NNP cord-333286-lr32e0w4 162 3 duration duration NN cord-333286-lr32e0w4 162 4 and and CC cord-333286-lr32e0w4 162 5 antibiotic antibiotic JJ cord-333286-lr32e0w4 162 6 use use NN cord-333286-lr32e0w4 162 7 ) ) -RRB- cord-333286-lr32e0w4 162 8 . . . cord-333286-lr32e0w4 163 1 Interestingly interestingly RB cord-333286-lr32e0w4 163 2 , , , cord-333286-lr32e0w4 163 3 these these DT cord-333286-lr32e0w4 163 4 strains strain NNS cord-333286-lr32e0w4 163 5 have have VBP cord-333286-lr32e0w4 163 6 shown show VBN cord-333286-lr32e0w4 163 7 in in IN cord-333286-lr32e0w4 163 8 vitro vitro FW cord-333286-lr32e0w4 163 9 the the DT cord-333286-lr32e0w4 163 10 ability ability NN cord-333286-lr32e0w4 163 11 to to TO cord-333286-lr32e0w4 163 12 induce induce VB cord-333286-lr32e0w4 163 13 antiviral antiviral JJ cord-333286-lr32e0w4 163 14 IFN IFN NNP cord-333286-lr32e0w4 163 15 signaling signal VBG cord-333286-lr32e0w4 163 16 pathways pathway NNS cord-333286-lr32e0w4 163 17 ( ( -LRB- cord-333286-lr32e0w4 163 18 see see VB cord-333286-lr32e0w4 163 19 Section section NN cord-333286-lr32e0w4 163 20 4.2 4.2 CD cord-333286-lr32e0w4 163 21 ) ) -RRB- cord-333286-lr32e0w4 163 22 which which WDT cord-333286-lr32e0w4 163 23 may may MD cord-333286-lr32e0w4 163 24 potentially potentially RB cord-333286-lr32e0w4 163 25 explain explain VB cord-333286-lr32e0w4 163 26 their -PRON- PRP$ cord-333286-lr32e0w4 163 27 beneficial beneficial JJ cord-333286-lr32e0w4 163 28 effects effect NNS cord-333286-lr32e0w4 163 29 observed observe VBN cord-333286-lr32e0w4 163 30 in in IN cord-333286-lr32e0w4 163 31 RTIs rti NNS cord-333286-lr32e0w4 163 32 . . . cord-333286-lr32e0w4 164 1 However however RB cord-333286-lr32e0w4 164 2 , , , cord-333286-lr32e0w4 164 3 as as IN cord-333286-lr32e0w4 164 4 multiple multiple JJ cord-333286-lr32e0w4 164 5 studies study NNS cord-333286-lr32e0w4 164 6 with with IN cord-333286-lr32e0w4 164 7 probiotic probiotic JJ cord-333286-lr32e0w4 164 8 strains strain NNS cord-333286-lr32e0w4 164 9 other other JJ cord-333286-lr32e0w4 164 10 than than IN cord-333286-lr32e0w4 164 11 L. L. NNP cord-333286-lr32e0w4 164 12 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 164 13 GG GG NNP cord-333286-lr32e0w4 164 14 are be VBP cord-333286-lr32e0w4 164 15 limited limit VBN cord-333286-lr32e0w4 164 16 or or CC cord-333286-lr32e0w4 164 17 lacking lacking JJ cord-333286-lr32e0w4 164 18 , , , cord-333286-lr32e0w4 164 19 comparison comparison NN cord-333286-lr32e0w4 164 20 and and CC cord-333286-lr32e0w4 164 21 interpretation interpretation NN cord-333286-lr32e0w4 164 22 of of IN cord-333286-lr32e0w4 164 23 the the DT cord-333286-lr32e0w4 164 24 strain strain NN cord-333286-lr32e0w4 164 25 specific specific JJ cord-333286-lr32e0w4 164 26 results result NNS cord-333286-lr32e0w4 164 27 should should MD cord-333286-lr32e0w4 164 28 be be VB cord-333286-lr32e0w4 164 29 made make VBN cord-333286-lr32e0w4 164 30 carefully carefully RB cord-333286-lr32e0w4 164 31 . . . cord-333286-lr32e0w4 165 1 Meta Meta NNP cord-333286-lr32e0w4 165 2 - - HYPH cord-333286-lr32e0w4 165 3 analyses analysis NNS cord-333286-lr32e0w4 165 4 that that WDT cord-333286-lr32e0w4 165 5 pool pool VBP cord-333286-lr32e0w4 165 6 data datum NNS cord-333286-lr32e0w4 165 7 from from IN cord-333286-lr32e0w4 165 8 clinical clinical JJ cord-333286-lr32e0w4 165 9 trials trial NNS cord-333286-lr32e0w4 165 10 conducted conduct VBN cord-333286-lr32e0w4 165 11 with with IN cord-333286-lr32e0w4 165 12 children child NNS cord-333286-lr32e0w4 165 13 , , , cord-333286-lr32e0w4 165 14 adults adult NNS cord-333286-lr32e0w4 165 15 , , , cord-333286-lr32e0w4 165 16 and and CC cord-333286-lr32e0w4 165 17 the the DT cord-333286-lr32e0w4 165 18 elderly elderly JJ cord-333286-lr32e0w4 165 19 show show VBP cord-333286-lr32e0w4 165 20 that that IN cord-333286-lr32e0w4 165 21 probiotic probiotic JJ cord-333286-lr32e0w4 165 22 use use NN cord-333286-lr32e0w4 165 23 is be VBZ cord-333286-lr32e0w4 165 24 more more RBR cord-333286-lr32e0w4 165 25 beneficial beneficial JJ cord-333286-lr32e0w4 165 26 over over IN cord-333286-lr32e0w4 165 27 placebo placebo NN cord-333286-lr32e0w4 165 28 in in IN cord-333286-lr32e0w4 165 29 reducing reduce VBG cord-333286-lr32e0w4 165 30 the the DT cord-333286-lr32e0w4 165 31 number number NN cord-333286-lr32e0w4 165 32 of of IN cord-333286-lr32e0w4 165 33 participants participant NNS cord-333286-lr32e0w4 165 34 experiencing experience VBG cord-333286-lr32e0w4 165 35 episodes episode NNS cord-333286-lr32e0w4 165 36 of of IN cord-333286-lr32e0w4 165 37 acute acute JJ cord-333286-lr32e0w4 165 38 URTI URTI NNP cord-333286-lr32e0w4 165 39 [ [ -LRB- cord-333286-lr32e0w4 165 40 5 5 CD cord-333286-lr32e0w4 165 41 , , , cord-333286-lr32e0w4 165 42 6 6 CD cord-333286-lr32e0w4 165 43 ] ] -RRB- cord-333286-lr32e0w4 165 44 , , , cord-333286-lr32e0w4 165 45 reducing reduce VBG cord-333286-lr32e0w4 165 46 antibiotic antibiotic JJ cord-333286-lr32e0w4 165 47 prescription prescription NN cord-333286-lr32e0w4 165 48 rates rate NNS cord-333286-lr32e0w4 165 49 for for IN cord-333286-lr32e0w4 165 50 acute acute JJ cord-333286-lr32e0w4 165 51 URTIs urti NNS cord-333286-lr32e0w4 165 52 [ [ -LRB- cord-333286-lr32e0w4 165 53 5 5 CD cord-333286-lr32e0w4 165 54 , , , cord-333286-lr32e0w4 165 55 6 6 CD cord-333286-lr32e0w4 165 56 ] ] -RRB- cord-333286-lr32e0w4 165 57 , , , cord-333286-lr32e0w4 165 58 and and CC cord-333286-lr32e0w4 165 59 reducing reduce VBG cord-333286-lr32e0w4 165 60 the the DT cord-333286-lr32e0w4 165 61 mean mean JJ cord-333286-lr32e0w4 165 62 duration duration NN cord-333286-lr32e0w4 165 63 of of IN cord-333286-lr32e0w4 165 64 an an DT cord-333286-lr32e0w4 165 65 episode episode NN cord-333286-lr32e0w4 165 66 of of IN cord-333286-lr32e0w4 165 67 an an DT cord-333286-lr32e0w4 165 68 acute acute JJ cord-333286-lr32e0w4 165 69 URTI URTI NNP cord-333286-lr32e0w4 165 70 as as RB cord-333286-lr32e0w4 165 71 well well RB cord-333286-lr32e0w4 165 72 as as IN cord-333286-lr32e0w4 165 73 cold cold RB cord-333286-lr32e0w4 165 74 - - HYPH cord-333286-lr32e0w4 165 75 related relate VBN cord-333286-lr32e0w4 165 76 school school NN cord-333286-lr32e0w4 165 77 absences absence NNS cord-333286-lr32e0w4 165 78 [ [ -LRB- cord-333286-lr32e0w4 165 79 5 5 CD cord-333286-lr32e0w4 165 80 , , , cord-333286-lr32e0w4 165 81 45 45 CD cord-333286-lr32e0w4 165 82 ] ] -RRB- cord-333286-lr32e0w4 165 83 . . . cord-333286-lr32e0w4 166 1 When when WRB cord-333286-lr32e0w4 166 2 the the DT cord-333286-lr32e0w4 166 3 literature literature NN cord-333286-lr32e0w4 166 4 search search NN cord-333286-lr32e0w4 166 5 was be VBD cord-333286-lr32e0w4 166 6 conducted conduct VBN cord-333286-lr32e0w4 166 7 , , , cord-333286-lr32e0w4 166 8 meta meta NNP cord-333286-lr32e0w4 166 9 - - HYPH cord-333286-lr32e0w4 166 10 analyses analysis NNS cord-333286-lr32e0w4 166 11 were be VBD cord-333286-lr32e0w4 166 12 not not RB cord-333286-lr32e0w4 166 13 found find VBN cord-333286-lr32e0w4 166 14 in in IN cord-333286-lr32e0w4 166 15 the the DT cord-333286-lr32e0w4 166 16 databases database NNS cord-333286-lr32e0w4 166 17 searched search VBN cord-333286-lr32e0w4 166 18 on on IN cord-333286-lr32e0w4 166 19 probiotic probiotic JJ cord-333286-lr32e0w4 166 20 effects effect NNS cord-333286-lr32e0w4 166 21 on on IN cord-333286-lr32e0w4 166 22 respiratory respiratory JJ cord-333286-lr32e0w4 166 23 infections infection NNS cord-333286-lr32e0w4 166 24 restricted restrict VBN cord-333286-lr32e0w4 166 25 to to IN cord-333286-lr32e0w4 166 26 the the DT cord-333286-lr32e0w4 166 27 elderly elderly JJ cord-333286-lr32e0w4 166 28 population population NN cord-333286-lr32e0w4 166 29 , , , cord-333286-lr32e0w4 166 30 potentially potentially RB cord-333286-lr32e0w4 166 31 due due IN cord-333286-lr32e0w4 166 32 to to IN cord-333286-lr32e0w4 166 33 the the DT cord-333286-lr32e0w4 166 34 fact fact NN cord-333286-lr32e0w4 166 35 that that IN cord-333286-lr32e0w4 166 36 data datum NNS cord-333286-lr32e0w4 166 37 are be VBP cord-333286-lr32e0w4 166 38 fairly fairly RB cord-333286-lr32e0w4 166 39 limited limited JJ cord-333286-lr32e0w4 166 40 regarding regard VBG cord-333286-lr32e0w4 166 41 this this DT cord-333286-lr32e0w4 166 42 age age NN cord-333286-lr32e0w4 166 43 group group NN cord-333286-lr32e0w4 166 44 . . . cord-333286-lr32e0w4 167 1 While while IN cord-333286-lr32e0w4 167 2 there there EX cord-333286-lr32e0w4 167 3 is be VBZ cord-333286-lr32e0w4 167 4 consensus consensus NN cord-333286-lr32e0w4 167 5 that that IN cord-333286-lr32e0w4 167 6 probiotics probiotic NNS cord-333286-lr32e0w4 167 7 could could MD cord-333286-lr32e0w4 167 8 have have VB cord-333286-lr32e0w4 167 9 potential potential NN cord-333286-lr32e0w4 167 10 in in IN cord-333286-lr32e0w4 167 11 reducing reduce VBG cord-333286-lr32e0w4 167 12 the the DT cord-333286-lr32e0w4 167 13 risk risk NN cord-333286-lr32e0w4 167 14 for for IN cord-333286-lr32e0w4 167 15 RTIs rti NNS cord-333286-lr32e0w4 167 16 , , , cord-333286-lr32e0w4 167 17 it -PRON- PRP cord-333286-lr32e0w4 167 18 should should MD cord-333286-lr32e0w4 167 19 be be VB cord-333286-lr32e0w4 167 20 noted note VBN cord-333286-lr32e0w4 167 21 that that IN cord-333286-lr32e0w4 167 22 clinical clinical JJ cord-333286-lr32e0w4 167 23 trials trial NNS cord-333286-lr32e0w4 167 24 in in IN cord-333286-lr32e0w4 167 25 the the DT cord-333286-lr32e0w4 167 26 meta meta NNP cord-333286-lr32e0w4 167 27 - - HYPH cord-333286-lr32e0w4 167 28 analyses analysis NNS cord-333286-lr32e0w4 167 29 have have VBP cord-333286-lr32e0w4 167 30 been be VBN cord-333286-lr32e0w4 167 31 conducted conduct VBN cord-333286-lr32e0w4 167 32 in in IN cord-333286-lr32e0w4 167 33 populations population NNS cord-333286-lr32e0w4 167 34 of of IN cord-333286-lr32e0w4 167 35 different different JJ cord-333286-lr32e0w4 167 36 ages age NNS cord-333286-lr32e0w4 167 37 and and CC cord-333286-lr32e0w4 167 38 genetic genetic JJ cord-333286-lr32e0w4 167 39 backgrounds background NNS cord-333286-lr32e0w4 167 40 , , , cord-333286-lr32e0w4 167 41 with with IN cord-333286-lr32e0w4 167 42 various various JJ cord-333286-lr32e0w4 167 43 strains strain NNS cord-333286-lr32e0w4 167 44 and/or and/or CC cord-333286-lr32e0w4 167 45 their -PRON- PRP$ cord-333286-lr32e0w4 167 46 combinations combination NNS cord-333286-lr32e0w4 167 47 , , , cord-333286-lr32e0w4 167 48 supplementation supplementation NN cord-333286-lr32e0w4 167 49 matrices matrix NNS cord-333286-lr32e0w4 167 50 , , , cord-333286-lr32e0w4 167 51 and and CC cord-333286-lr32e0w4 167 52 doses dose NNS cord-333286-lr32e0w4 167 53 . . . cord-333286-lr32e0w4 168 1 Moreover moreover RB cord-333286-lr32e0w4 168 2 , , , cord-333286-lr32e0w4 168 3 the the DT cord-333286-lr32e0w4 168 4 measured measure VBN cord-333286-lr32e0w4 168 5 outcomes outcome NNS cord-333286-lr32e0w4 168 6 and and CC cord-333286-lr32e0w4 168 7 data datum NNS cord-333286-lr32e0w4 168 8 collection collection NN cord-333286-lr32e0w4 168 9 procedures procedure NNS cord-333286-lr32e0w4 168 10 between between IN cord-333286-lr32e0w4 168 11 the the DT cord-333286-lr32e0w4 168 12 trials trial NNS cord-333286-lr32e0w4 168 13 ( ( -LRB- cord-333286-lr32e0w4 168 14 i.e. i.e. FW cord-333286-lr32e0w4 168 15 , , , cord-333286-lr32e0w4 168 16 infection infection NN cord-333286-lr32e0w4 168 17 episode episode NN cord-333286-lr32e0w4 168 18 definition definition NN cord-333286-lr32e0w4 168 19 ) ) -RRB- cord-333286-lr32e0w4 168 20 are be VBP cord-333286-lr32e0w4 168 21 not not RB cord-333286-lr32e0w4 168 22 harmonized harmonize VBN cord-333286-lr32e0w4 168 23 and and CC cord-333286-lr32e0w4 168 24 therefore therefore RB cord-333286-lr32e0w4 168 25 may may MD cord-333286-lr32e0w4 168 26 vary vary VB cord-333286-lr32e0w4 168 27 considerably considerably RB cord-333286-lr32e0w4 168 28 . . . cord-333286-lr32e0w4 169 1 Consequently consequently RB cord-333286-lr32e0w4 169 2 , , , cord-333286-lr32e0w4 169 3 pooling pool VBG cord-333286-lr32e0w4 169 4 all all PDT cord-333286-lr32e0w4 169 5 the the DT cord-333286-lr32e0w4 169 6 data data NN cord-333286-lr32e0w4 169 7 creates create VBZ cord-333286-lr32e0w4 169 8 a a DT cord-333286-lr32e0w4 169 9 bias bias NN cord-333286-lr32e0w4 169 10 , , , cord-333286-lr32e0w4 169 11 as as IN cord-333286-lr32e0w4 169 12 the the DT cord-333286-lr32e0w4 169 13 probiotic probiotic JJ cord-333286-lr32e0w4 169 14 effect effect NN cord-333286-lr32e0w4 169 15 is be VBZ cord-333286-lr32e0w4 169 16 generally generally RB cord-333286-lr32e0w4 169 17 dependent dependent JJ cord-333286-lr32e0w4 169 18 on on IN cord-333286-lr32e0w4 169 19 the the DT cord-333286-lr32e0w4 169 20 dose dose NN cord-333286-lr32e0w4 169 21 , , , cord-333286-lr32e0w4 169 22 population population NN cord-333286-lr32e0w4 169 23 , , , cord-333286-lr32e0w4 169 24 and and CC cord-333286-lr32e0w4 169 25 strain strain VB cord-333286-lr32e0w4 169 26 . . . cord-333286-lr32e0w4 170 1 Moreover moreover RB cord-333286-lr32e0w4 170 2 , , , cord-333286-lr32e0w4 170 3 as as IN cord-333286-lr32e0w4 170 4 discussed discuss VBN cord-333286-lr32e0w4 170 5 above above RB cord-333286-lr32e0w4 170 6 , , , cord-333286-lr32e0w4 170 7 the the DT cord-333286-lr32e0w4 170 8 probiotics probiotic NNS cord-333286-lr32e0w4 170 9 effects effect NNS cord-333286-lr32e0w4 170 10 on on IN cord-333286-lr32e0w4 170 11 the the DT cord-333286-lr32e0w4 170 12 immune immune JJ cord-333286-lr32e0w4 170 13 system system NN cord-333286-lr32e0w4 170 14 are be VBP cord-333286-lr32e0w4 170 15 strain strain NN cord-333286-lr32e0w4 170 16 - - HYPH cord-333286-lr32e0w4 170 17 specific specific JJ cord-333286-lr32e0w4 170 18 which which WDT cord-333286-lr32e0w4 170 19 affects affect VBZ cord-333286-lr32e0w4 170 20 the the DT cord-333286-lr32e0w4 170 21 interpretation interpretation NN cord-333286-lr32e0w4 170 22 of of IN cord-333286-lr32e0w4 170 23 the the DT cord-333286-lr32e0w4 170 24 results result NNS cord-333286-lr32e0w4 170 25 . . . cord-333286-lr32e0w4 171 1 With with IN cord-333286-lr32e0w4 171 2 regard regard NN cord-333286-lr32e0w4 171 3 to to IN cord-333286-lr32e0w4 171 4 probiotics probiotic NNS cord-333286-lr32e0w4 171 5 effects effect NNS cord-333286-lr32e0w4 171 6 to to IN cord-333286-lr32e0w4 171 7 specific specific JJ cord-333286-lr32e0w4 171 8 respiratory respiratory JJ cord-333286-lr32e0w4 171 9 viruses virus NNS cord-333286-lr32e0w4 171 10 in in IN cord-333286-lr32e0w4 171 11 clinical clinical JJ cord-333286-lr32e0w4 171 12 settings setting NNS cord-333286-lr32e0w4 171 13 , , , cord-333286-lr32e0w4 171 14 several several JJ cord-333286-lr32e0w4 171 15 trials trial NNS cord-333286-lr32e0w4 171 16 have have VBP cord-333286-lr32e0w4 171 17 characterized characterize VBN cord-333286-lr32e0w4 171 18 the the DT cord-333286-lr32e0w4 171 19 respiratory respiratory JJ cord-333286-lr32e0w4 171 20 infection infection NN cord-333286-lr32e0w4 171 21 etiology etiology NN cord-333286-lr32e0w4 171 22 in in IN cord-333286-lr32e0w4 171 23 infants infant NNS cord-333286-lr32e0w4 171 24 [ [ -LRB- cord-333286-lr32e0w4 171 25 81 81 CD cord-333286-lr32e0w4 171 26 ] ] -RRB- cord-333286-lr32e0w4 171 27 , , , cord-333286-lr32e0w4 171 28 in in IN cord-333286-lr32e0w4 171 29 children child NNS cord-333286-lr32e0w4 171 30 [ [ -LRB- cord-333286-lr32e0w4 171 31 82 82 CD cord-333286-lr32e0w4 171 32 ] ] -RRB- cord-333286-lr32e0w4 171 33 [ [ -LRB- cord-333286-lr32e0w4 171 34 83 83 CD cord-333286-lr32e0w4 171 35 ] ] -RRB- cord-333286-lr32e0w4 171 36 [ [ -LRB- cord-333286-lr32e0w4 171 37 84 84 CD cord-333286-lr32e0w4 171 38 ] ] -RRB- cord-333286-lr32e0w4 171 39 , , , cord-333286-lr32e0w4 171 40 in in IN cord-333286-lr32e0w4 171 41 adults adult NNS cord-333286-lr32e0w4 171 42 [ [ -LRB- cord-333286-lr32e0w4 171 43 85 85 CD cord-333286-lr32e0w4 171 44 ] ] -RRB- cord-333286-lr32e0w4 171 45 , , , cord-333286-lr32e0w4 171 46 and and CC cord-333286-lr32e0w4 171 47 in in IN cord-333286-lr32e0w4 171 48 the the DT cord-333286-lr32e0w4 171 49 elderly elderly JJ cord-333286-lr32e0w4 171 50 [ [ -LRB- cord-333286-lr32e0w4 171 51 86 86 CD cord-333286-lr32e0w4 171 52 ] ] -RRB- cord-333286-lr32e0w4 171 53 . . . cord-333286-lr32e0w4 172 1 In in IN cord-333286-lr32e0w4 172 2 addition addition NN cord-333286-lr32e0w4 172 3 , , , cord-333286-lr32e0w4 172 4 two two CD cord-333286-lr32e0w4 172 5 clinical clinical JJ cord-333286-lr32e0w4 172 6 trials trial NNS cord-333286-lr32e0w4 172 7 have have VBP cord-333286-lr32e0w4 172 8 investigated investigate VBN cord-333286-lr32e0w4 172 9 the the DT cord-333286-lr32e0w4 172 10 efficacy efficacy NN cord-333286-lr32e0w4 172 11 of of IN cord-333286-lr32e0w4 172 12 probiotics probiotic NNS cord-333286-lr32e0w4 172 13 in in IN cord-333286-lr32e0w4 172 14 an an DT cord-333286-lr32e0w4 172 15 experimental experimental JJ cord-333286-lr32e0w4 172 16 rhinovirus rhinovirus NN cord-333286-lr32e0w4 172 17 challenge challenge NN cord-333286-lr32e0w4 172 18 model model NN cord-333286-lr32e0w4 172 19 [ [ -LRB- cord-333286-lr32e0w4 172 20 87 87 CD cord-333286-lr32e0w4 172 21 ] ] -RRB- cord-333286-lr32e0w4 172 22 [ [ -LRB- cord-333286-lr32e0w4 172 23 88 88 CD cord-333286-lr32e0w4 172 24 ] ] -RRB- cord-333286-lr32e0w4 173 1 [ [ -LRB- cord-333286-lr32e0w4 173 2 89 89 CD cord-333286-lr32e0w4 173 3 ] ] -RRB- cord-333286-lr32e0w4 174 1 ( ( -LRB- cord-333286-lr32e0w4 174 2 Table table NN cord-333286-lr32e0w4 174 3 2 2 CD cord-333286-lr32e0w4 174 4 ) ) -RRB- cord-333286-lr32e0w4 174 5 . . . cord-333286-lr32e0w4 175 1 Children child NNS cord-333286-lr32e0w4 175 2 had have VBD cord-333286-lr32e0w4 175 3 less less JJR cord-333286-lr32e0w4 175 4 days day NNS cord-333286-lr32e0w4 175 5 with with IN cord-333286-lr32e0w4 175 6 respiratory respiratory JJ cord-333286-lr32e0w4 175 7 symptoms symptom NNS cord-333286-lr32e0w4 175 8 per per IN cord-333286-lr32e0w4 175 9 month month NN cord-333286-lr32e0w4 175 10 ( ( -LRB- cord-333286-lr32e0w4 175 11 6.5 6.5 CD cord-333286-lr32e0w4 175 12 vs. vs. IN cord-333286-lr32e0w4 175 13 7.2 7.2 CD cord-333286-lr32e0w4 175 14 , , , cord-333286-lr32e0w4 175 15 p p NN cord-333286-lr32e0w4 175 16 < < XX cord-333286-lr32e0w4 175 17 0.001 0.001 CD cord-333286-lr32e0w4 175 18 ) ) -RRB- cord-333286-lr32e0w4 175 19 . . . cord-333286-lr32e0w4 176 1 No no DT cord-333286-lr32e0w4 176 2 effect effect NN cord-333286-lr32e0w4 176 3 on on IN cord-333286-lr32e0w4 176 4 the the DT cord-333286-lr32e0w4 176 5 occurrence occurrence NN cord-333286-lr32e0w4 176 6 of of IN cord-333286-lr32e0w4 176 7 respiratory respiratory JJ cord-333286-lr32e0w4 176 8 viruses virus NNS cord-333286-lr32e0w4 176 9 during during IN cord-333286-lr32e0w4 176 10 the the DT cord-333286-lr32e0w4 176 11 study study NN cord-333286-lr32e0w4 176 12 or or CC cord-333286-lr32e0w4 176 13 respiratory respiratory JJ cord-333286-lr32e0w4 176 14 symptoms symptom NNS cord-333286-lr32e0w4 176 15 associated associate VBN cord-333286-lr32e0w4 176 16 with with IN cord-333286-lr32e0w4 176 17 viral viral JJ cord-333286-lr32e0w4 176 18 findings finding NNS cord-333286-lr32e0w4 176 19 . . . cord-333286-lr32e0w4 177 1 L. L. NNP cord-333286-lr32e0w4 177 2 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 177 3 GG GG NNP cord-333286-lr32e0w4 178 1 10 10 CD cord-333286-lr32e0w4 178 2 9 9 CD cord-333286-lr32e0w4 178 3 CFU CFU NNS cord-333286-lr32e0w4 178 4 of of IN cord-333286-lr32e0w4 178 5 live live JJ cord-333286-lr32e0w4 178 6 or or CC cord-333286-lr32e0w4 178 7 heat heat NN cord-333286-lr32e0w4 178 8 - - HYPH cord-333286-lr32e0w4 178 9 inactivated inactivate VBN cord-333286-lr32e0w4 178 10 ( ( -LRB- cord-333286-lr32e0w4 178 11 by by IN cord-333286-lr32e0w4 178 12 spray spray NN cord-333286-lr32e0w4 178 13 - - HYPH cord-333286-lr32e0w4 178 14 drying drying NN cord-333286-lr32e0w4 178 15 ) ) -RRB- cord-333286-lr32e0w4 178 16 in in IN cord-333286-lr32e0w4 178 17 100 100 CD cord-333286-lr32e0w4 178 18 mL ml NN cord-333286-lr32e0w4 178 19 of of IN cord-333286-lr32e0w4 178 20 fruit fruit NN cord-333286-lr32e0w4 178 21 juice juice NN cord-333286-lr32e0w4 178 22 or or CC cord-333286-lr32e0w4 178 23 control control NN cord-333286-lr32e0w4 178 24 juice juice NN cord-333286-lr32e0w4 178 25 daily daily RB cord-333286-lr32e0w4 178 26 for for IN cord-333286-lr32e0w4 178 27 6 6 CD cord-333286-lr32e0w4 178 28 weeks week NNS cord-333286-lr32e0w4 178 29 . . . cord-333286-lr32e0w4 179 1 In in IN cord-333286-lr32e0w4 179 2 the the DT cord-333286-lr32e0w4 179 3 clinical clinical JJ cord-333286-lr32e0w4 179 4 trials trial NNS cord-333286-lr32e0w4 179 5 conducted conduct VBN cord-333286-lr32e0w4 179 6 in in IN cord-333286-lr32e0w4 179 7 free free RB cord-333286-lr32e0w4 179 8 - - HYPH cord-333286-lr32e0w4 179 9 living live VBG cord-333286-lr32e0w4 179 10 subjects subject NNS cord-333286-lr32e0w4 179 11 in in IN cord-333286-lr32e0w4 179 12 the the DT cord-333286-lr32e0w4 179 13 community community NN cord-333286-lr32e0w4 179 14 , , , cord-333286-lr32e0w4 179 15 no no DT cord-333286-lr32e0w4 179 16 consistent consistent JJ cord-333286-lr32e0w4 179 17 data datum NNS cord-333286-lr32e0w4 179 18 exist exist VBP cord-333286-lr32e0w4 179 19 that that WDT cord-333286-lr32e0w4 179 20 show show VBP cord-333286-lr32e0w4 179 21 that that IN cord-333286-lr32e0w4 179 22 specific specific JJ cord-333286-lr32e0w4 179 23 probiotics probiotic NNS cord-333286-lr32e0w4 179 24 would would MD cord-333286-lr32e0w4 179 25 reduce reduce VB cord-333286-lr32e0w4 179 26 the the DT cord-333286-lr32e0w4 179 27 incidence incidence NN cord-333286-lr32e0w4 179 28 of of IN cord-333286-lr32e0w4 179 29 laboratory laboratory NN cord-333286-lr32e0w4 179 30 - - HYPH cord-333286-lr32e0w4 179 31 confirmed confirm VBN cord-333286-lr32e0w4 179 32 respiratory respiratory JJ cord-333286-lr32e0w4 179 33 virus virus NN cord-333286-lr32e0w4 179 34 infections infection NNS cord-333286-lr32e0w4 179 35 as as IN cord-333286-lr32e0w4 179 36 such such JJ cord-333286-lr32e0w4 179 37 . . . cord-333286-lr32e0w4 180 1 In in IN cord-333286-lr32e0w4 180 2 preterm preterm JJ cord-333286-lr32e0w4 180 3 infants infant NNS cord-333286-lr32e0w4 180 4 , , , cord-333286-lr32e0w4 180 5 the the DT cord-333286-lr32e0w4 180 6 use use NN cord-333286-lr32e0w4 180 7 of of IN cord-333286-lr32e0w4 180 8 L. L. NNP cord-333286-lr32e0w4 180 9 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 180 10 GG GG NNP cord-333286-lr32e0w4 180 11 for for IN cord-333286-lr32e0w4 180 12 60 60 CD cord-333286-lr32e0w4 180 13 days day NNS cord-333286-lr32e0w4 180 14 was be VBD cord-333286-lr32e0w4 180 15 associated associate VBN cord-333286-lr32e0w4 180 16 with with IN cord-333286-lr32e0w4 180 17 lower low JJR cord-333286-lr32e0w4 180 18 incidence incidence NN cord-333286-lr32e0w4 180 19 of of IN cord-333286-lr32e0w4 180 20 rhinovirus rhinovirus NN cord-333286-lr32e0w4 180 21 - - HYPH cord-333286-lr32e0w4 180 22 induced induce VBN cord-333286-lr32e0w4 180 23 episodes episode NNS cord-333286-lr32e0w4 180 24 ( ( -LRB- cord-333286-lr32e0w4 180 25 comprising comprise VBG cord-333286-lr32e0w4 180 26 80 80 CD cord-333286-lr32e0w4 180 27 % % NN cord-333286-lr32e0w4 180 28 of of IN cord-333286-lr32e0w4 180 29 all all DT cord-333286-lr32e0w4 180 30 RTI RTI NNP cord-333286-lr32e0w4 180 31 episodes episode NNS cord-333286-lr32e0w4 180 32 ) ) -RRB- cord-333286-lr32e0w4 180 33 compared compare VBN cord-333286-lr32e0w4 180 34 with with IN cord-333286-lr32e0w4 180 35 the the DT cord-333286-lr32e0w4 180 36 placebo placebo NN cord-333286-lr32e0w4 180 37 . . . cord-333286-lr32e0w4 181 1 However however RB cord-333286-lr32e0w4 181 2 , , , cord-333286-lr32e0w4 181 3 L. L. NNP cord-333286-lr32e0w4 181 4 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 181 5 GG GG NNP cord-333286-lr32e0w4 181 6 had have VBD cord-333286-lr32e0w4 181 7 no no DT cord-333286-lr32e0w4 181 8 effect effect NN cord-333286-lr32e0w4 181 9 on on IN cord-333286-lr32e0w4 181 10 rhinovirus rhinovirus NN cord-333286-lr32e0w4 181 11 RNA RNA NNP cord-333286-lr32e0w4 181 12 load load NN cord-333286-lr32e0w4 181 13 during during IN cord-333286-lr32e0w4 181 14 infections infection NNS cord-333286-lr32e0w4 181 15 , , , cord-333286-lr32e0w4 181 16 duration duration NN cord-333286-lr32e0w4 181 17 of of IN cord-333286-lr32e0w4 181 18 rhinovirus rhinovirus NN cord-333286-lr32e0w4 181 19 RNA RNA NNP cord-333286-lr32e0w4 181 20 shedding shedding NN cord-333286-lr32e0w4 181 21 , , , cord-333286-lr32e0w4 181 22 duration duration NN cord-333286-lr32e0w4 181 23 or or CC cord-333286-lr32e0w4 181 24 severity severity NN cord-333286-lr32e0w4 181 25 of of IN cord-333286-lr32e0w4 181 26 rhinovirus rhinovirus NN cord-333286-lr32e0w4 181 27 infection infection NN cord-333286-lr32e0w4 181 28 , , , cord-333286-lr32e0w4 181 29 or or CC cord-333286-lr32e0w4 181 30 the the DT cord-333286-lr32e0w4 181 31 occurrence occurrence NN cord-333286-lr32e0w4 181 32 of of IN cord-333286-lr32e0w4 181 33 rhinovirus rhinovirus NN cord-333286-lr32e0w4 181 34 RNA RNA NNP cord-333286-lr32e0w4 181 35 in in IN cord-333286-lr32e0w4 181 36 asymptomatic asymptomatic JJ cord-333286-lr32e0w4 181 37 infants infant NNS cord-333286-lr32e0w4 181 38 . . . cord-333286-lr32e0w4 182 1 In in IN cord-333286-lr32e0w4 182 2 children child NNS cord-333286-lr32e0w4 182 3 attending attend VBG cord-333286-lr32e0w4 182 4 daycare daycare NN cord-333286-lr32e0w4 182 5 , , , cord-333286-lr32e0w4 182 6 L. L. NNP cord-333286-lr32e0w4 182 7 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 182 8 GG GG NNP cord-333286-lr32e0w4 182 9 [ [ -LRB- cord-333286-lr32e0w4 182 10 83 83 CD cord-333286-lr32e0w4 182 11 ] ] -RRB- cord-333286-lr32e0w4 182 12 consumption consumption NN cord-333286-lr32e0w4 182 13 for for IN cord-333286-lr32e0w4 182 14 28 28 CD cord-333286-lr32e0w4 182 15 weeks week NNS cord-333286-lr32e0w4 182 16 did do VBD cord-333286-lr32e0w4 182 17 not not RB cord-333286-lr32e0w4 182 18 reduce reduce VB cord-333286-lr32e0w4 182 19 the the DT cord-333286-lr32e0w4 182 20 occurrence occurrence NN cord-333286-lr32e0w4 182 21 of of IN cord-333286-lr32e0w4 182 22 any any DT cord-333286-lr32e0w4 182 23 of of IN cord-333286-lr32e0w4 182 24 the the DT cord-333286-lr32e0w4 182 25 common common JJ cord-333286-lr32e0w4 182 26 respiratory respiratory JJ cord-333286-lr32e0w4 182 27 viruses virus NNS cord-333286-lr32e0w4 182 28 either either RB cord-333286-lr32e0w4 182 29 . . . cord-333286-lr32e0w4 183 1 In in IN cord-333286-lr32e0w4 183 2 otitis otitis NN cord-333286-lr32e0w4 183 3 - - HYPH cord-333286-lr32e0w4 183 4 prone prone JJ cord-333286-lr32e0w4 183 5 children child NNS cord-333286-lr32e0w4 183 6 , , , cord-333286-lr32e0w4 183 7 supplementation supplementation NN cord-333286-lr32e0w4 183 8 of of IN cord-333286-lr32e0w4 183 9 a a DT cord-333286-lr32e0w4 183 10 combination combination NN cord-333286-lr32e0w4 183 11 of of IN cord-333286-lr32e0w4 183 12 L. L. NNP cord-333286-lr32e0w4 183 13 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 183 14 GG GG NNP cord-333286-lr32e0w4 183 15 , , , cord-333286-lr32e0w4 183 16 L. L. NNP cord-333286-lr32e0w4 183 17 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 183 18 Lc705 Lc705 NNP cord-333286-lr32e0w4 183 19 , , , cord-333286-lr32e0w4 183 20 B. B. NNP cord-333286-lr32e0w4 183 21 breve breve NNP cord-333286-lr32e0w4 183 22 99 99 CD cord-333286-lr32e0w4 183 23 , , , cord-333286-lr32e0w4 183 24 and and CC cord-333286-lr32e0w4 183 25 Propionibacterium Propionibacterium NNP cord-333286-lr32e0w4 183 26 jensenii jensenii NNP cord-333286-lr32e0w4 183 27 JS JS NNP cord-333286-lr32e0w4 183 28 , , , cord-333286-lr32e0w4 183 29 for for IN cord-333286-lr32e0w4 183 30 six six CD cord-333286-lr32e0w4 183 31 months month NNS cord-333286-lr32e0w4 183 32 , , , cord-333286-lr32e0w4 183 33 reduced reduce VBD cord-333286-lr32e0w4 183 34 the the DT cord-333286-lr32e0w4 183 35 number number NN cord-333286-lr32e0w4 183 36 of of IN cord-333286-lr32e0w4 183 37 human human JJ cord-333286-lr32e0w4 183 38 bocavirus bocavirus NN cord-333286-lr32e0w4 183 39 - - HYPH cord-333286-lr32e0w4 183 40 positive positive JJ cord-333286-lr32e0w4 183 41 nasopharyngeal nasopharyngeal JJ cord-333286-lr32e0w4 183 42 samples sample NNS cord-333286-lr32e0w4 183 43 when when WRB cord-333286-lr32e0w4 183 44 compared compare VBN cord-333286-lr32e0w4 183 45 with with IN cord-333286-lr32e0w4 183 46 placebo placebo NN cord-333286-lr32e0w4 183 47 , , , cord-333286-lr32e0w4 183 48 but but CC cord-333286-lr32e0w4 183 49 not not RB cord-333286-lr32e0w4 183 50 the the DT cord-333286-lr32e0w4 183 51 number number NN cord-333286-lr32e0w4 183 52 of of IN cord-333286-lr32e0w4 183 53 rhino rhino NN cord-333286-lr32e0w4 183 54 / / SYM cord-333286-lr32e0w4 183 55 enterovirus enterovirus NN cord-333286-lr32e0w4 183 56 - - HYPH cord-333286-lr32e0w4 183 57 positive positive JJ cord-333286-lr32e0w4 183 58 samples sample NNS cord-333286-lr32e0w4 183 59 [ [ -LRB- cord-333286-lr32e0w4 183 60 84 84 CD cord-333286-lr32e0w4 183 61 ] ] -RRB- cord-333286-lr32e0w4 183 62 . . . cord-333286-lr32e0w4 184 1 Furthermore furthermore RB cord-333286-lr32e0w4 184 2 , , , cord-333286-lr32e0w4 184 3 in in IN cord-333286-lr32e0w4 184 4 schoolchildren schoolchildren NNS cord-333286-lr32e0w4 184 5 , , , cord-333286-lr32e0w4 184 6 the the DT cord-333286-lr32e0w4 184 7 consumption consumption NN cord-333286-lr32e0w4 184 8 of of IN cord-333286-lr32e0w4 184 9 Levilactobacillus Levilactobacillus NNP cord-333286-lr32e0w4 184 10 brevis brevis NN cord-333286-lr32e0w4 184 11 KB290 KB290 NNP cord-333286-lr32e0w4 184 12 during during IN cord-333286-lr32e0w4 184 13 influenza influenza JJ cord-333286-lr32e0w4 184 14 season season NN cord-333286-lr32e0w4 184 15 was be VBD cord-333286-lr32e0w4 184 16 associated associate VBN cord-333286-lr32e0w4 184 17 with with IN cord-333286-lr32e0w4 184 18 lower low JJR cord-333286-lr32e0w4 184 19 incidence incidence NN cord-333286-lr32e0w4 184 20 of of IN cord-333286-lr32e0w4 184 21 physician physician NN cord-333286-lr32e0w4 184 22 - - HYPH cord-333286-lr32e0w4 184 23 diagnosed diagnose VBN cord-333286-lr32e0w4 184 24 influenza influenza NN cord-333286-lr32e0w4 184 25 virus virus NN cord-333286-lr32e0w4 184 26 cases case NNS cord-333286-lr32e0w4 184 27 [ [ -LRB- cord-333286-lr32e0w4 184 28 82 82 CD cord-333286-lr32e0w4 184 29 ] ] -RRB- cord-333286-lr32e0w4 184 30 . . . cord-333286-lr32e0w4 185 1 In in IN cord-333286-lr32e0w4 185 2 adults adult NNS cord-333286-lr32e0w4 185 3 attending attend VBG cord-333286-lr32e0w4 185 4 military military JJ cord-333286-lr32e0w4 185 5 service service NN cord-333286-lr32e0w4 185 6 , , , cord-333286-lr32e0w4 185 7 the the DT cord-333286-lr32e0w4 185 8 use use NN cord-333286-lr32e0w4 185 9 of of IN cord-333286-lr32e0w4 185 10 a a DT cord-333286-lr32e0w4 185 11 combination combination NN cord-333286-lr32e0w4 185 12 of of IN cord-333286-lr32e0w4 185 13 L. L. NNP cord-333286-lr32e0w4 185 14 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 185 15 GG GG NNP cord-333286-lr32e0w4 185 16 and and CC cord-333286-lr32e0w4 185 17 B. B. NNP cord-333286-lr32e0w4 185 18 lactis lactis NN cord-333286-lr32e0w4 185 19 BB-12 BB-12 NNP cord-333286-lr32e0w4 185 20 for for IN cord-333286-lr32e0w4 185 21 either either CC cord-333286-lr32e0w4 185 22 90 90 CD cord-333286-lr32e0w4 185 23 or or CC cord-333286-lr32e0w4 185 24 150 150 CD cord-333286-lr32e0w4 185 25 days day NNS cord-333286-lr32e0w4 185 26 was be VBD cord-333286-lr32e0w4 185 27 not not RB cord-333286-lr32e0w4 185 28 overall overall RB cord-333286-lr32e0w4 185 29 associated associate VBN cord-333286-lr32e0w4 185 30 with with IN cord-333286-lr32e0w4 185 31 lower low JJR cord-333286-lr32e0w4 185 32 occurrence occurrence NN cord-333286-lr32e0w4 185 33 of of IN cord-333286-lr32e0w4 185 34 common common JJ cord-333286-lr32e0w4 185 35 respiratory respiratory JJ cord-333286-lr32e0w4 185 36 viruses virus NNS cord-333286-lr32e0w4 185 37 upon upon IN cord-333286-lr32e0w4 185 38 presentation presentation NN cord-333286-lr32e0w4 185 39 of of IN cord-333286-lr32e0w4 185 40 cold cold JJ cord-333286-lr32e0w4 185 41 symptoms symptom NNS cord-333286-lr32e0w4 185 42 [ [ -LRB- cord-333286-lr32e0w4 185 43 85 85 CD cord-333286-lr32e0w4 185 44 ] ] -RRB- cord-333286-lr32e0w4 185 45 . . . cord-333286-lr32e0w4 186 1 However however RB cord-333286-lr32e0w4 186 2 , , , cord-333286-lr32e0w4 186 3 in in IN cord-333286-lr32e0w4 186 4 a a DT cord-333286-lr32e0w4 186 5 subgroup subgroup NN cord-333286-lr32e0w4 186 6 , , , cord-333286-lr32e0w4 186 7 there there EX cord-333286-lr32e0w4 186 8 was be VBD cord-333286-lr32e0w4 186 9 a a DT cord-333286-lr32e0w4 186 10 lower low JJR cord-333286-lr32e0w4 186 11 occurrence occurrence NN cord-333286-lr32e0w4 186 12 of of IN cord-333286-lr32e0w4 186 13 rhino rhino NN cord-333286-lr32e0w4 186 14 / / SYM cord-333286-lr32e0w4 186 15 enteroviruses enterovirus NNS cord-333286-lr32e0w4 186 16 after after IN cord-333286-lr32e0w4 186 17 three three CD cord-333286-lr32e0w4 186 18 months month NNS cord-333286-lr32e0w4 186 19 in in IN cord-333286-lr32e0w4 186 20 the the DT cord-333286-lr32e0w4 186 21 probiotic probiotic JJ cord-333286-lr32e0w4 186 22 group group NN cord-333286-lr32e0w4 186 23 when when WRB cord-333286-lr32e0w4 186 24 compared compare VBN cord-333286-lr32e0w4 186 25 with with IN cord-333286-lr32e0w4 186 26 the the DT cord-333286-lr32e0w4 186 27 placebo placebo NN cord-333286-lr32e0w4 186 28 . . . cord-333286-lr32e0w4 187 1 In in IN cord-333286-lr32e0w4 187 2 nursing nursing NN cord-333286-lr32e0w4 187 3 home home NN cord-333286-lr32e0w4 187 4 residents resident NNS cord-333286-lr32e0w4 187 5 , , , cord-333286-lr32e0w4 187 6 Wang Wang NNP cord-333286-lr32e0w4 187 7 et et NNP cord-333286-lr32e0w4 187 8 al al NNP cord-333286-lr32e0w4 187 9 . . NNP cord-333286-lr32e0w4 187 10 , , , cord-333286-lr32e0w4 187 11 2018 2018 CD cord-333286-lr32e0w4 187 12 , , , cord-333286-lr32e0w4 187 13 reported report VBD cord-333286-lr32e0w4 187 14 that that IN cord-333286-lr32e0w4 187 15 the the DT cord-333286-lr32e0w4 187 16 use use NN cord-333286-lr32e0w4 187 17 of of IN cord-333286-lr32e0w4 187 18 L. L. NNP cord-333286-lr32e0w4 187 19 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 187 20 GG GG NNP cord-333286-lr32e0w4 187 21 for for IN cord-333286-lr32e0w4 187 22 six six CD cord-333286-lr32e0w4 187 23 months month NNS cord-333286-lr32e0w4 187 24 was be VBD cord-333286-lr32e0w4 187 25 not not RB cord-333286-lr32e0w4 187 26 associated associate VBN cord-333286-lr32e0w4 187 27 with with IN cord-333286-lr32e0w4 187 28 the the DT cord-333286-lr32e0w4 187 29 reduction reduction NN cord-333286-lr32e0w4 187 30 in in IN cord-333286-lr32e0w4 187 31 occurrence occurrence NN cord-333286-lr32e0w4 187 32 of of IN cord-333286-lr32e0w4 187 33 confirmed confirm VBN cord-333286-lr32e0w4 187 34 viral viral JJ cord-333286-lr32e0w4 187 35 respiratory respiratory JJ cord-333286-lr32e0w4 187 36 infections infection NNS cord-333286-lr32e0w4 187 37 [ [ -LRB- cord-333286-lr32e0w4 187 38 86 86 CD cord-333286-lr32e0w4 187 39 ] ] -RRB- cord-333286-lr32e0w4 187 40 . . . cord-333286-lr32e0w4 188 1 The the DT cord-333286-lr32e0w4 188 2 differences difference NNS cord-333286-lr32e0w4 188 3 between between IN cord-333286-lr32e0w4 188 4 the the DT cord-333286-lr32e0w4 188 5 findings finding NNS cord-333286-lr32e0w4 188 6 in in IN cord-333286-lr32e0w4 188 7 these these DT cord-333286-lr32e0w4 188 8 trials trial NNS cord-333286-lr32e0w4 188 9 may may MD cord-333286-lr32e0w4 188 10 be be VB cord-333286-lr32e0w4 188 11 explained explain VBN cord-333286-lr32e0w4 188 12 by by IN cord-333286-lr32e0w4 188 13 the the DT cord-333286-lr32e0w4 188 14 fact fact NN cord-333286-lr32e0w4 188 15 that that IN cord-333286-lr32e0w4 188 16 these these DT cord-333286-lr32e0w4 188 17 studies study NNS cord-333286-lr32e0w4 188 18 were be VBD cord-333286-lr32e0w4 188 19 conducted conduct VBN cord-333286-lr32e0w4 188 20 in in IN cord-333286-lr32e0w4 188 21 various various JJ cord-333286-lr32e0w4 188 22 age age NN cord-333286-lr32e0w4 188 23 groups group NNS cord-333286-lr32e0w4 188 24 with with IN cord-333286-lr32e0w4 188 25 different different JJ cord-333286-lr32e0w4 188 26 immune immune JJ cord-333286-lr32e0w4 188 27 system system NN cord-333286-lr32e0w4 188 28 statuses status NNS cord-333286-lr32e0w4 188 29 ( ( -LRB- cord-333286-lr32e0w4 188 30 infants infant NNS cord-333286-lr32e0w4 188 31 vs. vs. IN cord-333286-lr32e0w4 188 32 children child NNS cord-333286-lr32e0w4 188 33 vs. vs. IN cord-333286-lr32e0w4 188 34 healthy healthy JJ cord-333286-lr32e0w4 188 35 adults adult NNS cord-333286-lr32e0w4 188 36 vs. vs. IN cord-333286-lr32e0w4 188 37 the the DT cord-333286-lr32e0w4 188 38 elderly elderly JJ cord-333286-lr32e0w4 188 39 ) ) -RRB- cord-333286-lr32e0w4 188 40 , , , cord-333286-lr32e0w4 188 41 different different JJ cord-333286-lr32e0w4 188 42 seasons season NNS cord-333286-lr32e0w4 188 43 , , , cord-333286-lr32e0w4 188 44 as as RB cord-333286-lr32e0w4 188 45 well well RB cord-333286-lr32e0w4 188 46 as as IN cord-333286-lr32e0w4 188 47 variable variable JJ cord-333286-lr32e0w4 188 48 probiotic probiotic JJ cord-333286-lr32e0w4 188 49 strains strain NNS cord-333286-lr32e0w4 188 50 , , , cord-333286-lr32e0w4 188 51 strain strain NN cord-333286-lr32e0w4 188 52 combinations combination NNS cord-333286-lr32e0w4 188 53 , , , cord-333286-lr32e0w4 188 54 doses dose NNS cord-333286-lr32e0w4 188 55 , , , cord-333286-lr32e0w4 188 56 and and CC cord-333286-lr32e0w4 188 57 variable variable JJ cord-333286-lr32e0w4 188 58 lengths length NNS cord-333286-lr32e0w4 188 59 of of IN cord-333286-lr32e0w4 188 60 intervention intervention NN cord-333286-lr32e0w4 188 61 . . . cord-333286-lr32e0w4 189 1 Furthermore furthermore RB cord-333286-lr32e0w4 189 2 , , , cord-333286-lr32e0w4 189 3 most most JJS cord-333286-lr32e0w4 189 4 of of IN cord-333286-lr32e0w4 189 5 the the DT cord-333286-lr32e0w4 189 6 studies study NNS cord-333286-lr32e0w4 189 7 were be VBD cord-333286-lr32e0w4 189 8 not not RB cord-333286-lr32e0w4 189 9 designed design VBN cord-333286-lr32e0w4 189 10 for for IN cord-333286-lr32e0w4 189 11 analyzing analyze VBG cord-333286-lr32e0w4 189 12 the the DT cord-333286-lr32e0w4 189 13 viral viral JJ cord-333286-lr32e0w4 189 14 infection infection NN cord-333286-lr32e0w4 189 15 etiology etiology NN cord-333286-lr32e0w4 189 16 as as IN cord-333286-lr32e0w4 189 17 the the DT cord-333286-lr32e0w4 189 18 primary primary JJ cord-333286-lr32e0w4 189 19 outcome outcome NN cord-333286-lr32e0w4 189 20 and and CC cord-333286-lr32e0w4 189 21 the the DT cord-333286-lr32e0w4 189 22 diagnosis diagnosis NN cord-333286-lr32e0w4 189 23 for for IN cord-333286-lr32e0w4 189 24 the the DT cord-333286-lr32e0w4 189 25 identification identification NN cord-333286-lr32e0w4 189 26 of of IN cord-333286-lr32e0w4 189 27 the the DT cord-333286-lr32e0w4 189 28 viral viral JJ cord-333286-lr32e0w4 189 29 agent agent NN cord-333286-lr32e0w4 189 30 was be VBD cord-333286-lr32e0w4 189 31 not not RB cord-333286-lr32e0w4 189 32 applied apply VBN cord-333286-lr32e0w4 189 33 . . . cord-333286-lr32e0w4 190 1 Since since IN cord-333286-lr32e0w4 190 2 over over IN cord-333286-lr32e0w4 190 3 200 200 CD cord-333286-lr32e0w4 190 4 respiratory respiratory JJ cord-333286-lr32e0w4 190 5 virus virus NN cord-333286-lr32e0w4 190 6 types type NNS cord-333286-lr32e0w4 190 7 can can MD cord-333286-lr32e0w4 190 8 cause cause VB cord-333286-lr32e0w4 190 9 respiratory respiratory JJ cord-333286-lr32e0w4 190 10 infections infection NNS cord-333286-lr32e0w4 190 11 and and CC cord-333286-lr32e0w4 190 12 , , , cord-333286-lr32e0w4 190 13 in in IN cord-333286-lr32e0w4 190 14 many many JJ cord-333286-lr32e0w4 190 15 cases case NNS cord-333286-lr32e0w4 190 16 , , , cord-333286-lr32e0w4 190 17 the the DT cord-333286-lr32e0w4 190 18 infections infection NNS cord-333286-lr32e0w4 190 19 and and CC cord-333286-lr32e0w4 190 20 symptoms symptom NNS cord-333286-lr32e0w4 190 21 overlap overlap VBP cord-333286-lr32e0w4 190 22 , , , cord-333286-lr32e0w4 190 23 or or CC cord-333286-lr32e0w4 190 24 the the DT cord-333286-lr32e0w4 190 25 etiology etiology NN cord-333286-lr32e0w4 190 26 is be VBZ cord-333286-lr32e0w4 190 27 undiagnosed undiagnosed JJ cord-333286-lr32e0w4 190 28 , , , cord-333286-lr32e0w4 190 29 the the DT cord-333286-lr32e0w4 190 30 potential potential JJ cord-333286-lr32e0w4 190 31 antiviral antiviral JJ cord-333286-lr32e0w4 190 32 effects effect NNS cord-333286-lr32e0w4 190 33 of of IN cord-333286-lr32e0w4 190 34 probiotics probiotic NNS cord-333286-lr32e0w4 190 35 against against IN cord-333286-lr32e0w4 190 36 specific specific JJ cord-333286-lr32e0w4 190 37 viruses virus NNS cord-333286-lr32e0w4 190 38 can can MD cord-333286-lr32e0w4 190 39 be be VB cord-333286-lr32e0w4 190 40 difficult difficult JJ cord-333286-lr32e0w4 190 41 to to TO cord-333286-lr32e0w4 190 42 determine determine VB cord-333286-lr32e0w4 190 43 in in IN cord-333286-lr32e0w4 190 44 clinical clinical JJ cord-333286-lr32e0w4 190 45 trials trial NNS cord-333286-lr32e0w4 190 46 targeting target VBG cord-333286-lr32e0w4 190 47 free free JJ cord-333286-lr32e0w4 190 48 - - HYPH cord-333286-lr32e0w4 190 49 living live VBG cord-333286-lr32e0w4 190 50 subjects subject NNS cord-333286-lr32e0w4 190 51 within within IN cord-333286-lr32e0w4 190 52 the the DT cord-333286-lr32e0w4 190 53 community community NN cord-333286-lr32e0w4 190 54 . . . cord-333286-lr32e0w4 191 1 To to TO cord-333286-lr32e0w4 191 2 overcome overcome VB cord-333286-lr32e0w4 191 3 this this DT cord-333286-lr32e0w4 191 4 caveat caveat NN cord-333286-lr32e0w4 191 5 , , , cord-333286-lr32e0w4 191 6 two two CD cord-333286-lr32e0w4 191 7 probiotics probiotic NNS cord-333286-lr32e0w4 191 8 have have VBP cord-333286-lr32e0w4 191 9 been be VBN cord-333286-lr32e0w4 191 10 investigated investigate VBN cord-333286-lr32e0w4 191 11 in in IN cord-333286-lr32e0w4 191 12 an an DT cord-333286-lr32e0w4 191 13 experimental experimental JJ cord-333286-lr32e0w4 191 14 rhinovirus rhinovirus NN cord-333286-lr32e0w4 191 15 challenge challenge NN cord-333286-lr32e0w4 191 16 model model NN cord-333286-lr32e0w4 191 17 that that WDT cord-333286-lr32e0w4 191 18 allows allow VBZ cord-333286-lr32e0w4 191 19 investigation investigation NN cord-333286-lr32e0w4 191 20 of of IN cord-333286-lr32e0w4 191 21 the the DT cord-333286-lr32e0w4 191 22 effect effect NN cord-333286-lr32e0w4 191 23 of of IN cord-333286-lr32e0w4 191 24 a a DT cord-333286-lr32e0w4 191 25 probiotic probiotic JJ cord-333286-lr32e0w4 191 26 strain strain NN cord-333286-lr32e0w4 191 27 to to IN cord-333286-lr32e0w4 191 28 a a DT cord-333286-lr32e0w4 191 29 specific specific JJ cord-333286-lr32e0w4 191 30 viral viral JJ cord-333286-lr32e0w4 191 31 pathogen pathogen NN cord-333286-lr32e0w4 191 32 . . . cord-333286-lr32e0w4 192 1 In in IN cord-333286-lr32e0w4 192 2 a a DT cord-333286-lr32e0w4 192 3 rhinovirus rhinovirus NN cord-333286-lr32e0w4 192 4 ( ( -LRB- cord-333286-lr32e0w4 192 5 type type NN cord-333286-lr32e0w4 192 6 39 39 CD cord-333286-lr32e0w4 192 7 ) ) -RRB- cord-333286-lr32e0w4 192 8 challenge challenge NN cord-333286-lr32e0w4 192 9 model model NN cord-333286-lr32e0w4 192 10 , , , cord-333286-lr32e0w4 192 11 B. B. NNP cord-333286-lr32e0w4 192 12 lactis lactis NNP cord-333286-lr32e0w4 193 1 Bl-04 Bl-04 NNP cord-333286-lr32e0w4 193 2 was be VBD cord-333286-lr32e0w4 193 3 administered administer VBN cord-333286-lr32e0w4 193 4 for for IN cord-333286-lr32e0w4 193 5 28 28 CD cord-333286-lr32e0w4 193 6 days day NNS cord-333286-lr32e0w4 193 7 prior prior RB cord-333286-lr32e0w4 193 8 and and CC cord-333286-lr32e0w4 193 9 during during IN cord-333286-lr32e0w4 193 10 five five CD cord-333286-lr32e0w4 193 11 days day NNS cord-333286-lr32e0w4 193 12 of of IN cord-333286-lr32e0w4 193 13 experimental experimental JJ cord-333286-lr32e0w4 193 14 rhinovirus rhinovirus NN cord-333286-lr32e0w4 193 15 infection infection NN cord-333286-lr32e0w4 193 16 to to IN cord-333286-lr32e0w4 193 17 healthy healthy JJ cord-333286-lr32e0w4 193 18 volunteers volunteer NNS cord-333286-lr32e0w4 193 19 [ [ -LRB- cord-333286-lr32e0w4 193 20 89 89 CD cord-333286-lr32e0w4 193 21 ] ] -RRB- cord-333286-lr32e0w4 193 22 . . . cord-333286-lr32e0w4 194 1 B. B. NNP cord-333286-lr32e0w4 194 2 lactis lactis NNP cord-333286-lr32e0w4 195 1 Bl-04 Bl-04 NNP cord-333286-lr32e0w4 196 1 supplementation supplementation NN cord-333286-lr32e0w4 196 2 resulted result VBD cord-333286-lr32e0w4 196 3 in in IN cord-333286-lr32e0w4 196 4 significantly significantly RB cord-333286-lr32e0w4 196 5 lower low JJR cord-333286-lr32e0w4 196 6 rhinovirus rhinovirus NN cord-333286-lr32e0w4 196 7 titers titer NNS cord-333286-lr32e0w4 196 8 in in IN cord-333286-lr32e0w4 196 9 nasal nasal NN cord-333286-lr32e0w4 196 10 washes wash NNS cord-333286-lr32e0w4 196 11 during during IN cord-333286-lr32e0w4 196 12 the the DT cord-333286-lr32e0w4 196 13 infection infection NN cord-333286-lr32e0w4 196 14 as as RB cord-333286-lr32e0w4 196 15 well well RB cord-333286-lr32e0w4 196 16 as as IN cord-333286-lr32e0w4 196 17 in in IN cord-333286-lr32e0w4 196 18 a a DT cord-333286-lr32e0w4 196 19 lower low JJR cord-333286-lr32e0w4 196 20 number number NN cord-333286-lr32e0w4 196 21 of of IN cord-333286-lr32e0w4 196 22 infected infected JJ cord-333286-lr32e0w4 196 23 participants participant NNS cord-333286-lr32e0w4 196 24 shedding shed VBG cord-333286-lr32e0w4 196 25 the the DT cord-333286-lr32e0w4 196 26 virus virus NN cord-333286-lr32e0w4 196 27 compared compare VBN cord-333286-lr32e0w4 196 28 with with IN cord-333286-lr32e0w4 196 29 the the DT cord-333286-lr32e0w4 196 30 placebo placebo NN cord-333286-lr32e0w4 196 31 . . . cord-333286-lr32e0w4 197 1 Moreover moreover RB cord-333286-lr32e0w4 197 2 , , , cord-333286-lr32e0w4 197 3 B. B. NNP cord-333286-lr32e0w4 197 4 lactis lactis NNP cord-333286-lr32e0w4 197 5 Bl-04 Bl-04 NNP cord-333286-lr32e0w4 197 6 induced induce VBD cord-333286-lr32e0w4 197 7 a a DT cord-333286-lr32e0w4 197 8 significantly significantly RB cord-333286-lr32e0w4 197 9 higher high JJR cord-333286-lr32e0w4 197 10 concentration concentration NN cord-333286-lr32e0w4 197 11 of of IN cord-333286-lr32e0w4 197 12 IL-8 il-8 NN cord-333286-lr32e0w4 197 13 in in IN cord-333286-lr32e0w4 197 14 nasal nasal NN cord-333286-lr32e0w4 197 15 washes wash NNS cord-333286-lr32e0w4 197 16 after after IN cord-333286-lr32e0w4 197 17 28 28 CD cord-333286-lr32e0w4 197 18 days day NNS cord-333286-lr32e0w4 197 19 of of IN cord-333286-lr32e0w4 197 20 supplementation supplementation NN cord-333286-lr32e0w4 197 21 and and CC cord-333286-lr32e0w4 197 22 prior prior RB cord-333286-lr32e0w4 197 23 to to IN cord-333286-lr32e0w4 197 24 infection infection NN cord-333286-lr32e0w4 197 25 . . . cord-333286-lr32e0w4 198 1 Given give VBN cord-333286-lr32e0w4 198 2 the the DT cord-333286-lr32e0w4 198 3 reduced reduce VBN cord-333286-lr32e0w4 198 4 viral viral JJ cord-333286-lr32e0w4 198 5 titer titer NN cord-333286-lr32e0w4 198 6 , , , cord-333286-lr32e0w4 198 7 an an DT cord-333286-lr32e0w4 198 8 increase increase NN cord-333286-lr32e0w4 198 9 in in IN cord-333286-lr32e0w4 198 10 IL-8 IL-8 NNP cord-333286-lr32e0w4 198 11 could could MD cord-333286-lr32e0w4 198 12 indicate indicate VB cord-333286-lr32e0w4 198 13 priming prime VBG cord-333286-lr32e0w4 198 14 of of IN cord-333286-lr32e0w4 198 15 the the DT cord-333286-lr32e0w4 198 16 mucosal mucosal JJ cord-333286-lr32e0w4 198 17 immune immune JJ cord-333286-lr32e0w4 198 18 system system NN cord-333286-lr32e0w4 198 19 prior prior RB cord-333286-lr32e0w4 198 20 to to IN cord-333286-lr32e0w4 198 21 infection infection NN cord-333286-lr32e0w4 198 22 . . . cord-333286-lr32e0w4 199 1 This this DT cord-333286-lr32e0w4 199 2 hypothesis hypothesis NN cord-333286-lr32e0w4 199 3 is be VBZ cord-333286-lr32e0w4 199 4 in in IN cord-333286-lr32e0w4 199 5 line line NN cord-333286-lr32e0w4 199 6 with with IN cord-333286-lr32e0w4 199 7 a a DT cord-333286-lr32e0w4 199 8 clinical clinical JJ cord-333286-lr32e0w4 199 9 study study NN cord-333286-lr32e0w4 199 10 conducted conduct VBN cord-333286-lr32e0w4 199 11 in in IN cord-333286-lr32e0w4 199 12 healthy healthy JJ cord-333286-lr32e0w4 199 13 active active JJ cord-333286-lr32e0w4 199 14 adults adult NNS cord-333286-lr32e0w4 199 15 , , , cord-333286-lr32e0w4 199 16 where where WRB cord-333286-lr32e0w4 199 17 supplementation supplementation NN cord-333286-lr32e0w4 199 18 of of IN cord-333286-lr32e0w4 199 19 B. B. NNP cord-333286-lr32e0w4 199 20 lactis lactis NNP cord-333286-lr32e0w4 199 21 Bl-04 Bl-04 NNP cord-333286-lr32e0w4 199 22 reduced reduce VBD cord-333286-lr32e0w4 199 23 the the DT cord-333286-lr32e0w4 199 24 risk risk NN cord-333286-lr32e0w4 199 25 of of IN cord-333286-lr32e0w4 199 26 URTI URTI NNP cord-333286-lr32e0w4 199 27 episodes episode NNS cord-333286-lr32e0w4 199 28 compared compare VBN cord-333286-lr32e0w4 199 29 with with IN cord-333286-lr32e0w4 199 30 placebo placebo NN cord-333286-lr32e0w4 199 31 [ [ -LRB- cord-333286-lr32e0w4 199 32 90 90 CD cord-333286-lr32e0w4 199 33 ] ] -RRB- cord-333286-lr32e0w4 199 34 . . . cord-333286-lr32e0w4 200 1 In in IN cord-333286-lr32e0w4 200 2 another another DT cord-333286-lr32e0w4 200 3 similar similar JJ cord-333286-lr32e0w4 200 4 experimental experimental JJ cord-333286-lr32e0w4 200 5 rhinovirus rhinovirus NN cord-333286-lr32e0w4 200 6 type type NN cord-333286-lr32e0w4 200 7 39 39 CD cord-333286-lr32e0w4 200 8 challenge challenge NN cord-333286-lr32e0w4 200 9 pilot pilot NN cord-333286-lr32e0w4 200 10 trial trial NN cord-333286-lr32e0w4 200 11 , , , cord-333286-lr32e0w4 200 12 no no DT cord-333286-lr32e0w4 200 13 significant significant JJ cord-333286-lr32e0w4 200 14 antiviral antiviral JJ cord-333286-lr32e0w4 200 15 effect effect NN cord-333286-lr32e0w4 200 16 was be VBD cord-333286-lr32e0w4 200 17 seen see VBN cord-333286-lr32e0w4 200 18 with with IN cord-333286-lr32e0w4 200 19 live live JJ cord-333286-lr32e0w4 200 20 or or CC cord-333286-lr32e0w4 200 21 inactivated inactivate VBN cord-333286-lr32e0w4 200 22 L. L. NNP cord-333286-lr32e0w4 200 23 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 200 24 GG GG NNP cord-333286-lr32e0w4 200 25 supplementation supplementation NN cord-333286-lr32e0w4 200 26 compared compare VBN cord-333286-lr32e0w4 200 27 with with IN cord-333286-lr32e0w4 200 28 placebo placebo NN cord-333286-lr32e0w4 200 29 [ [ -LRB- cord-333286-lr32e0w4 200 30 87 87 CD cord-333286-lr32e0w4 200 31 , , , cord-333286-lr32e0w4 200 32 88 88 CD cord-333286-lr32e0w4 200 33 ] ] -RRB- cord-333286-lr32e0w4 200 34 , , , cord-333286-lr32e0w4 200 35 suggesting suggest VBG cord-333286-lr32e0w4 200 36 potential potential JJ cord-333286-lr32e0w4 200 37 strain strain NN cord-333286-lr32e0w4 200 38 - - HYPH cord-333286-lr32e0w4 200 39 specific specific JJ cord-333286-lr32e0w4 200 40 differences difference NNS cord-333286-lr32e0w4 200 41 on on IN cord-333286-lr32e0w4 200 42 the the DT cord-333286-lr32e0w4 200 43 efficacy efficacy NN cord-333286-lr32e0w4 200 44 of of IN cord-333286-lr32e0w4 200 45 probiotics probiotic NNS cord-333286-lr32e0w4 200 46 in in IN cord-333286-lr32e0w4 200 47 respiratory respiratory JJ cord-333286-lr32e0w4 200 48 virus virus NN cord-333286-lr32e0w4 200 49 infections infection NNS cord-333286-lr32e0w4 200 50 . . . cord-333286-lr32e0w4 201 1 Nevertheless nevertheless RB cord-333286-lr32e0w4 201 2 , , , cord-333286-lr32e0w4 201 3 further far RBR cord-333286-lr32e0w4 201 4 adequately adequately RB cord-333286-lr32e0w4 201 5 powered power VBN cord-333286-lr32e0w4 201 6 trials trial NNS cord-333286-lr32e0w4 201 7 with with IN cord-333286-lr32e0w4 201 8 harmonized harmonize VBN cord-333286-lr32e0w4 201 9 study study NN cord-333286-lr32e0w4 201 10 designs design NNS cord-333286-lr32e0w4 201 11 are be VBP cord-333286-lr32e0w4 201 12 necessary necessary JJ cord-333286-lr32e0w4 201 13 to to TO cord-333286-lr32e0w4 201 14 draw draw VB cord-333286-lr32e0w4 201 15 conclusions conclusion NNS cord-333286-lr32e0w4 201 16 on on IN cord-333286-lr32e0w4 201 17 the the DT cord-333286-lr32e0w4 201 18 efficacy efficacy NN cord-333286-lr32e0w4 201 19 of of IN cord-333286-lr32e0w4 201 20 probiotics probiotic NNS cord-333286-lr32e0w4 201 21 against against IN cord-333286-lr32e0w4 201 22 specific specific JJ cord-333286-lr32e0w4 201 23 respiratory respiratory JJ cord-333286-lr32e0w4 201 24 viruses virus NNS cord-333286-lr32e0w4 201 25 . . . cord-333286-lr32e0w4 202 1 Viral viral JJ cord-333286-lr32e0w4 202 2 RTIs rti NNS cord-333286-lr32e0w4 202 3 are be VBP cord-333286-lr32e0w4 202 4 the the DT cord-333286-lr32e0w4 202 5 most most RBS cord-333286-lr32e0w4 202 6 common common JJ cord-333286-lr32e0w4 202 7 infections infection NNS cord-333286-lr32e0w4 202 8 of of IN cord-333286-lr32e0w4 202 9 mankind mankind NN cord-333286-lr32e0w4 202 10 and and CC cord-333286-lr32e0w4 202 11 the the DT cord-333286-lr32e0w4 202 12 health health NN cord-333286-lr32e0w4 202 13 and and CC cord-333286-lr32e0w4 202 14 financial financial JJ cord-333286-lr32e0w4 202 15 impact impact NN cord-333286-lr32e0w4 202 16 of of IN cord-333286-lr32e0w4 202 17 seasonal seasonal JJ cord-333286-lr32e0w4 202 18 epidemics epidemic NNS cord-333286-lr32e0w4 202 19 and and CC cord-333286-lr32e0w4 202 20 global global JJ cord-333286-lr32e0w4 202 21 pandemics pandemic NNS cord-333286-lr32e0w4 202 22 on on IN cord-333286-lr32e0w4 202 23 society society NN cord-333286-lr32e0w4 202 24 is be VBZ cord-333286-lr32e0w4 202 25 high high JJ cord-333286-lr32e0w4 202 26 . . . cord-333286-lr32e0w4 203 1 Due due IN cord-333286-lr32e0w4 203 2 to to IN cord-333286-lr32e0w4 203 3 the the DT cord-333286-lr32e0w4 203 4 large large JJ cord-333286-lr32e0w4 203 5 number number NN cord-333286-lr32e0w4 203 6 of of IN cord-333286-lr32e0w4 203 7 various various JJ cord-333286-lr32e0w4 203 8 respiratory respiratory JJ cord-333286-lr32e0w4 203 9 viruses virus NNS cord-333286-lr32e0w4 203 10 , , , cord-333286-lr32e0w4 203 11 the the DT cord-333286-lr32e0w4 203 12 development development NN cord-333286-lr32e0w4 203 13 of of IN cord-333286-lr32e0w4 203 14 efficient efficient JJ cord-333286-lr32e0w4 203 15 therapies therapy NNS cord-333286-lr32e0w4 203 16 , , , cord-333286-lr32e0w4 203 17 such such JJ cord-333286-lr32e0w4 203 18 as as IN cord-333286-lr32e0w4 203 19 vaccines vaccine NNS cord-333286-lr32e0w4 203 20 , , , cord-333286-lr32e0w4 203 21 is be VBZ cord-333286-lr32e0w4 203 22 challenging challenge VBG cord-333286-lr32e0w4 203 23 . . . cord-333286-lr32e0w4 204 1 When when WRB cord-333286-lr32e0w4 204 2 preventative preventative JJ cord-333286-lr32e0w4 204 3 measures measure NNS cord-333286-lr32e0w4 204 4 are be VBP cord-333286-lr32e0w4 204 5 scarce scarce JJ cord-333286-lr32e0w4 204 6 or or CC cord-333286-lr32e0w4 204 7 lacking lacking JJ cord-333286-lr32e0w4 204 8 , , , cord-333286-lr32e0w4 204 9 the the DT cord-333286-lr32e0w4 204 10 role role NN cord-333286-lr32e0w4 204 11 of of IN cord-333286-lr32e0w4 204 12 a a DT cord-333286-lr32e0w4 204 13 well well RB cord-333286-lr32e0w4 204 14 - - HYPH cord-333286-lr32e0w4 204 15 functioning function VBG cord-333286-lr32e0w4 204 16 immune immune JJ cord-333286-lr32e0w4 204 17 system system NN cord-333286-lr32e0w4 204 18 becomes become VBZ cord-333286-lr32e0w4 204 19 crucial crucial JJ cord-333286-lr32e0w4 204 20 for for IN cord-333286-lr32e0w4 204 21 providing provide VBG cord-333286-lr32e0w4 204 22 resistance resistance NN cord-333286-lr32e0w4 204 23 to to IN cord-333286-lr32e0w4 204 24 an an DT cord-333286-lr32e0w4 204 25 infection infection NN cord-333286-lr32e0w4 204 26 . . . cord-333286-lr32e0w4 205 1 Within within IN cord-333286-lr32e0w4 205 2 the the DT cord-333286-lr32e0w4 205 3 past past JJ cord-333286-lr32e0w4 205 4 decade decade NN cord-333286-lr32e0w4 205 5 , , , cord-333286-lr32e0w4 205 6 research research NN cord-333286-lr32e0w4 205 7 highlighting highlight VBG cord-333286-lr32e0w4 205 8 the the DT cord-333286-lr32e0w4 205 9 importance importance NN cord-333286-lr32e0w4 205 10 of of IN cord-333286-lr32e0w4 205 11 the the DT cord-333286-lr32e0w4 205 12 microbiota microbiota NN cord-333286-lr32e0w4 205 13 on on IN cord-333286-lr32e0w4 205 14 immune immune JJ cord-333286-lr32e0w4 205 15 system system NN cord-333286-lr32e0w4 205 16 function function NN cord-333286-lr32e0w4 205 17 has have VBZ cord-333286-lr32e0w4 205 18 raised raise VBN cord-333286-lr32e0w4 205 19 interest interest NN cord-333286-lr32e0w4 205 20 in in IN cord-333286-lr32e0w4 205 21 understanding understand VBG cord-333286-lr32e0w4 205 22 the the DT cord-333286-lr32e0w4 205 23 role role NN cord-333286-lr32e0w4 205 24 of of IN cord-333286-lr32e0w4 205 25 microbiota microbiota NN cord-333286-lr32e0w4 205 26 modulation modulation NN cord-333286-lr32e0w4 205 27 and and CC cord-333286-lr32e0w4 205 28 bacterial bacterial JJ cord-333286-lr32e0w4 205 29 therapeutics therapeutic NNS cord-333286-lr32e0w4 205 30 by by IN cord-333286-lr32e0w4 205 31 dietary dietary JJ cord-333286-lr32e0w4 205 32 and and CC cord-333286-lr32e0w4 205 33 pharmaceutical pharmaceutical JJ cord-333286-lr32e0w4 205 34 solutions solution NNS cord-333286-lr32e0w4 205 35 in in IN cord-333286-lr32e0w4 205 36 health health NN cord-333286-lr32e0w4 205 37 and and CC cord-333286-lr32e0w4 205 38 disease disease NN cord-333286-lr32e0w4 205 39 . . . cord-333286-lr32e0w4 206 1 Of of IN cord-333286-lr32e0w4 206 2 the the DT cord-333286-lr32e0w4 206 3 available available JJ cord-333286-lr32e0w4 206 4 solutions solution NNS cord-333286-lr32e0w4 206 5 , , , cord-333286-lr32e0w4 206 6 probiotic probiotic JJ cord-333286-lr32e0w4 206 7 bacteria bacteria NNS cord-333286-lr32e0w4 206 8 have have VBP cord-333286-lr32e0w4 206 9 been be VBN cord-333286-lr32e0w4 206 10 studied study VBN cord-333286-lr32e0w4 206 11 for for IN cord-333286-lr32e0w4 206 12 immune immune JJ cord-333286-lr32e0w4 206 13 function function NN cord-333286-lr32e0w4 206 14 modulation modulation NN cord-333286-lr32e0w4 206 15 in in IN cord-333286-lr32e0w4 206 16 the the DT cord-333286-lr32e0w4 206 17 context context NN cord-333286-lr32e0w4 206 18 of of IN cord-333286-lr32e0w4 206 19 respiratory respiratory JJ cord-333286-lr32e0w4 206 20 viral viral JJ cord-333286-lr32e0w4 206 21 infections infection NNS cord-333286-lr32e0w4 206 22 . . . cord-333286-lr32e0w4 207 1 In in IN cord-333286-lr32e0w4 207 2 this this DT cord-333286-lr32e0w4 207 3 review review NN cord-333286-lr32e0w4 207 4 , , , cord-333286-lr32e0w4 207 5 we -PRON- PRP cord-333286-lr32e0w4 207 6 have have VBP cord-333286-lr32e0w4 207 7 summarized summarize VBN cord-333286-lr32e0w4 207 8 the the DT cord-333286-lr32e0w4 207 9 current current JJ cord-333286-lr32e0w4 207 10 evidence evidence NN cord-333286-lr32e0w4 207 11 on on IN cord-333286-lr32e0w4 207 12 the the DT cord-333286-lr32e0w4 207 13 effects effect NNS cord-333286-lr32e0w4 207 14 of of IN cord-333286-lr32e0w4 207 15 probiotics probiotic NNS cord-333286-lr32e0w4 207 16 on on IN cord-333286-lr32e0w4 207 17 antiviral antiviral JJ cord-333286-lr32e0w4 207 18 immune immune JJ cord-333286-lr32e0w4 207 19 function function NN cord-333286-lr32e0w4 207 20 in in IN cord-333286-lr32e0w4 207 21 vitro vitro FW cord-333286-lr32e0w4 207 22 and and CC cord-333286-lr32e0w4 207 23 in in IN cord-333286-lr32e0w4 207 24 vivo vivo NN cord-333286-lr32e0w4 207 25 , , , cord-333286-lr32e0w4 207 26 and and CC cord-333286-lr32e0w4 207 27 clinical clinical JJ cord-333286-lr32e0w4 207 28 evidence evidence NN cord-333286-lr32e0w4 207 29 on on IN cord-333286-lr32e0w4 207 30 the the DT cord-333286-lr32e0w4 207 31 effect effect NN cord-333286-lr32e0w4 207 32 of of IN cord-333286-lr32e0w4 207 33 probiotics probiotic NNS cord-333286-lr32e0w4 207 34 on on IN cord-333286-lr32e0w4 207 35 viral viral JJ cord-333286-lr32e0w4 207 36 RTIs rti NNS cord-333286-lr32e0w4 207 37 and and CC cord-333286-lr32e0w4 207 38 on on IN cord-333286-lr32e0w4 207 39 the the DT cord-333286-lr32e0w4 207 40 course course NN cord-333286-lr32e0w4 207 41 of of IN cord-333286-lr32e0w4 207 42 RTI RTI NNP cord-333286-lr32e0w4 207 43 ( ( -LRB- cord-333286-lr32e0w4 207 44 Figure figure NN cord-333286-lr32e0w4 207 45 1 1 CD cord-333286-lr32e0w4 207 46 ) ) -RRB- cord-333286-lr32e0w4 207 47 . . . cord-333286-lr32e0w4 208 1 importance importance NN cord-333286-lr32e0w4 208 2 of of IN cord-333286-lr32e0w4 208 3 the the DT cord-333286-lr32e0w4 208 4 microbiota microbiota NN cord-333286-lr32e0w4 208 5 on on IN cord-333286-lr32e0w4 208 6 immune immune JJ cord-333286-lr32e0w4 208 7 system system NN cord-333286-lr32e0w4 208 8 function function NN cord-333286-lr32e0w4 208 9 has have VBZ cord-333286-lr32e0w4 208 10 raised raise VBN cord-333286-lr32e0w4 208 11 interest interest NN cord-333286-lr32e0w4 208 12 in in IN cord-333286-lr32e0w4 208 13 understanding understand VBG cord-333286-lr32e0w4 208 14 the the DT cord-333286-lr32e0w4 208 15 role role NN cord-333286-lr32e0w4 208 16 of of IN cord-333286-lr32e0w4 208 17 microbiota microbiota NN cord-333286-lr32e0w4 208 18 modulation modulation NN cord-333286-lr32e0w4 208 19 and and CC cord-333286-lr32e0w4 208 20 bacterial bacterial JJ cord-333286-lr32e0w4 208 21 therapeutics therapeutic NNS cord-333286-lr32e0w4 208 22 by by IN cord-333286-lr32e0w4 208 23 dietary dietary JJ cord-333286-lr32e0w4 208 24 and and CC cord-333286-lr32e0w4 208 25 pharmaceutical pharmaceutical JJ cord-333286-lr32e0w4 208 26 solutions solution NNS cord-333286-lr32e0w4 208 27 in in IN cord-333286-lr32e0w4 208 28 health health NN cord-333286-lr32e0w4 208 29 and and CC cord-333286-lr32e0w4 208 30 disease disease NN cord-333286-lr32e0w4 208 31 . . . cord-333286-lr32e0w4 209 1 Of of IN cord-333286-lr32e0w4 209 2 the the DT cord-333286-lr32e0w4 209 3 available available JJ cord-333286-lr32e0w4 209 4 solutions solution NNS cord-333286-lr32e0w4 209 5 , , , cord-333286-lr32e0w4 209 6 probiotic probiotic JJ cord-333286-lr32e0w4 209 7 bacteria bacteria NNS cord-333286-lr32e0w4 209 8 have have VBP cord-333286-lr32e0w4 209 9 been be VBN cord-333286-lr32e0w4 209 10 studied study VBN cord-333286-lr32e0w4 209 11 for for IN cord-333286-lr32e0w4 209 12 immune immune JJ cord-333286-lr32e0w4 209 13 function function NN cord-333286-lr32e0w4 209 14 modulation modulation NN cord-333286-lr32e0w4 209 15 in in IN cord-333286-lr32e0w4 209 16 the the DT cord-333286-lr32e0w4 209 17 context context NN cord-333286-lr32e0w4 209 18 of of IN cord-333286-lr32e0w4 209 19 respiratory respiratory JJ cord-333286-lr32e0w4 209 20 viral viral JJ cord-333286-lr32e0w4 209 21 infections infection NNS cord-333286-lr32e0w4 209 22 . . . cord-333286-lr32e0w4 210 1 In in IN cord-333286-lr32e0w4 210 2 this this DT cord-333286-lr32e0w4 210 3 review review NN cord-333286-lr32e0w4 210 4 , , , cord-333286-lr32e0w4 210 5 we -PRON- PRP cord-333286-lr32e0w4 210 6 have have VBP cord-333286-lr32e0w4 210 7 summarized summarize VBN cord-333286-lr32e0w4 210 8 the the DT cord-333286-lr32e0w4 210 9 current current JJ cord-333286-lr32e0w4 210 10 evidence evidence NN cord-333286-lr32e0w4 210 11 on on IN cord-333286-lr32e0w4 210 12 the the DT cord-333286-lr32e0w4 210 13 effects effect NNS cord-333286-lr32e0w4 210 14 of of IN cord-333286-lr32e0w4 210 15 probiotics probiotic NNS cord-333286-lr32e0w4 210 16 on on IN cord-333286-lr32e0w4 210 17 antiviral antiviral JJ cord-333286-lr32e0w4 210 18 immune immune JJ cord-333286-lr32e0w4 210 19 function function NN cord-333286-lr32e0w4 210 20 in in IN cord-333286-lr32e0w4 210 21 vitro vitro FW cord-333286-lr32e0w4 210 22 and and CC cord-333286-lr32e0w4 210 23 in in IN cord-333286-lr32e0w4 210 24 vivo vivo NN cord-333286-lr32e0w4 210 25 , , , cord-333286-lr32e0w4 210 26 and and CC cord-333286-lr32e0w4 210 27 clinical clinical JJ cord-333286-lr32e0w4 210 28 evidence evidence NN cord-333286-lr32e0w4 210 29 on on IN cord-333286-lr32e0w4 210 30 the the DT cord-333286-lr32e0w4 210 31 effect effect NN cord-333286-lr32e0w4 210 32 of of IN cord-333286-lr32e0w4 210 33 probiotics probiotic NNS cord-333286-lr32e0w4 210 34 on on IN cord-333286-lr32e0w4 210 35 viral viral JJ cord-333286-lr32e0w4 210 36 RTIs rti NNS cord-333286-lr32e0w4 210 37 and and CC cord-333286-lr32e0w4 210 38 on on IN cord-333286-lr32e0w4 210 39 the the DT cord-333286-lr32e0w4 210 40 course course NN cord-333286-lr32e0w4 210 41 of of IN cord-333286-lr32e0w4 210 42 RTI RTI NNP cord-333286-lr32e0w4 210 43 ( ( -LRB- cord-333286-lr32e0w4 210 44 Figure figure NN cord-333286-lr32e0w4 210 45 1 1 CD cord-333286-lr32e0w4 210 46 ) ) -RRB- cord-333286-lr32e0w4 210 47 . . . cord-333286-lr32e0w4 211 1 In in IN cord-333286-lr32e0w4 211 2 vitro vitro FW cord-333286-lr32e0w4 211 3 data datum NNS cord-333286-lr32e0w4 211 4 indicate indicate VBP cord-333286-lr32e0w4 211 5 that that IN cord-333286-lr32e0w4 211 6 probiotics probiotic NNS cord-333286-lr32e0w4 211 7 have have VBP cord-333286-lr32e0w4 211 8 strain strain NN cord-333286-lr32e0w4 211 9 - - HYPH cord-333286-lr32e0w4 211 10 specific specific JJ cord-333286-lr32e0w4 211 11 immunomodulatory immunomodulatory JJ cord-333286-lr32e0w4 211 12 effects effect NNS cord-333286-lr32e0w4 211 13 on on IN cord-333286-lr32e0w4 211 14 the the DT cord-333286-lr32e0w4 211 15 host host NN cord-333286-lr32e0w4 211 16 and and CC cord-333286-lr32e0w4 211 17 immune immune JJ cord-333286-lr32e0w4 211 18 cells cell NNS cord-333286-lr32e0w4 211 19 by by IN cord-333286-lr32e0w4 211 20 engaging engage VBG cord-333286-lr32e0w4 211 21 TLRs tlr NNS cord-333286-lr32e0w4 211 22 that that WDT cord-333286-lr32e0w4 211 23 stimulate stimulate VBP cord-333286-lr32e0w4 211 24 IFN IFN NNP cord-333286-lr32e0w4 211 25 pathways pathway NNS cord-333286-lr32e0w4 211 26 . . . cord-333286-lr32e0w4 212 1 The the DT cord-333286-lr32e0w4 212 2 upregulation upregulation NN cord-333286-lr32e0w4 212 3 of of IN cord-333286-lr32e0w4 212 4 IFN IFN NNP cord-333286-lr32e0w4 212 5 response response NN cord-333286-lr32e0w4 212 6 seems seem VBZ cord-333286-lr32e0w4 212 7 to to IN cord-333286-lr32e0w4 212 8 prime prime JJ cord-333286-lr32e0w4 212 9 cells cell NNS cord-333286-lr32e0w4 212 10 for for IN cord-333286-lr32e0w4 212 11 better well JJR cord-333286-lr32e0w4 212 12 resistance resistance NN cord-333286-lr32e0w4 212 13 against against IN cord-333286-lr32e0w4 212 14 virus virus NN cord-333286-lr32e0w4 212 15 infection infection NN cord-333286-lr32e0w4 212 16 as as IN cord-333286-lr32e0w4 212 17 probiotics probiotic NNS cord-333286-lr32e0w4 212 18 were be VBD cord-333286-lr32e0w4 212 19 shown show VBN cord-333286-lr32e0w4 212 20 effective effective JJ cord-333286-lr32e0w4 212 21 in in IN cord-333286-lr32e0w4 212 22 inhibiting inhibit VBG cord-333286-lr32e0w4 212 23 the the DT cord-333286-lr32e0w4 212 24 replication replication NN cord-333286-lr32e0w4 212 25 of of IN cord-333286-lr32e0w4 212 26 various various JJ cord-333286-lr32e0w4 212 27 respiratory respiratory JJ cord-333286-lr32e0w4 212 28 viruses virus NNS cord-333286-lr32e0w4 212 29 , , , cord-333286-lr32e0w4 212 30 including include VBG cord-333286-lr32e0w4 212 31 influenza influenza NN cord-333286-lr32e0w4 212 32 viruses virus NNS cord-333286-lr32e0w4 212 33 and and CC cord-333286-lr32e0w4 212 34 RSV RSV NNP cord-333286-lr32e0w4 212 35 . . . cord-333286-lr32e0w4 213 1 Similar similar JJ cord-333286-lr32e0w4 213 2 effects effect NNS cord-333286-lr32e0w4 213 3 have have VBP cord-333286-lr32e0w4 213 4 been be VBN cord-333286-lr32e0w4 213 5 demonstrated demonstrate VBN cord-333286-lr32e0w4 213 6 in in IN cord-333286-lr32e0w4 213 7 mice mouse NNS cord-333286-lr32e0w4 213 8 with with IN cord-333286-lr32e0w4 213 9 the the DT cord-333286-lr32e0w4 213 10 ability ability NN cord-333286-lr32e0w4 213 11 of of IN cord-333286-lr32e0w4 213 12 the the DT cord-333286-lr32e0w4 213 13 probiotics probiotic NNS cord-333286-lr32e0w4 213 14 to to TO cord-333286-lr32e0w4 213 15 reduce reduce VB cord-333286-lr32e0w4 213 16 virus virus NN cord-333286-lr32e0w4 213 17 titers titer NNS cord-333286-lr32e0w4 213 18 in in IN cord-333286-lr32e0w4 213 19 lung lung NN cord-333286-lr32e0w4 213 20 tissues tissue NNS cord-333286-lr32e0w4 213 21 and and CC cord-333286-lr32e0w4 213 22 to to TO cord-333286-lr32e0w4 213 23 modulate modulate VB cord-333286-lr32e0w4 213 24 antiviral antiviral JJ cord-333286-lr32e0w4 213 25 and and CC cord-333286-lr32e0w4 213 26 pro pro JJ cord-333286-lr32e0w4 213 27 - - JJ cord-333286-lr32e0w4 213 28 inflammatory inflammatory JJ cord-333286-lr32e0w4 213 29 gene gene NN cord-333286-lr32e0w4 213 30 expression expression NN cord-333286-lr32e0w4 213 31 before before IN cord-333286-lr32e0w4 213 32 and and CC cord-333286-lr32e0w4 213 33 after after IN cord-333286-lr32e0w4 213 34 viral viral JJ cord-333286-lr32e0w4 213 35 infection infection NN cord-333286-lr32e0w4 213 36 . . . cord-333286-lr32e0w4 214 1 Interestingly interestingly RB cord-333286-lr32e0w4 214 2 , , , cord-333286-lr32e0w4 214 3 some some DT cord-333286-lr32e0w4 214 4 studies study NNS cord-333286-lr32e0w4 214 5 in in IN cord-333286-lr32e0w4 214 6 mice mouse NNS cord-333286-lr32e0w4 214 7 show show VBP cord-333286-lr32e0w4 214 8 an an DT cord-333286-lr32e0w4 214 9 increase increase NN cord-333286-lr32e0w4 214 10 in in IN cord-333286-lr32e0w4 214 11 IL-10 IL-10 NNP cord-333286-lr32e0w4 214 12 response response NN cord-333286-lr32e0w4 214 13 , , , cord-333286-lr32e0w4 214 14 suggesting suggest VBG cord-333286-lr32e0w4 214 15 control control NN cord-333286-lr32e0w4 214 16 of of IN cord-333286-lr32e0w4 214 17 the the DT cord-333286-lr32e0w4 214 18 pro pro JJ cord-333286-lr32e0w4 214 19 - - JJ cord-333286-lr32e0w4 214 20 inflammatory inflammatory JJ cord-333286-lr32e0w4 214 21 response response NN cord-333286-lr32e0w4 214 22 that that WDT cord-333286-lr32e0w4 214 23 typically typically RB cord-333286-lr32e0w4 214 24 drives drive VBZ cord-333286-lr32e0w4 214 25 lung lung NN cord-333286-lr32e0w4 214 26 pathology pathology NN cord-333286-lr32e0w4 214 27 in in IN cord-333286-lr32e0w4 214 28 severe severe JJ cord-333286-lr32e0w4 214 29 infections infection NNS cord-333286-lr32e0w4 214 30 . . . cord-333286-lr32e0w4 215 1 Most Most JJS cord-333286-lr32e0w4 215 2 likely likely JJ cord-333286-lr32e0w4 215 3 probiotics probiotic NNS cord-333286-lr32e0w4 215 4 ' ' POS cord-333286-lr32e0w4 215 5 effects effect NNS cord-333286-lr32e0w4 215 6 in in IN cord-333286-lr32e0w4 215 7 the the DT cord-333286-lr32e0w4 215 8 gut gut NN cord-333286-lr32e0w4 215 9 are be VBP cord-333286-lr32e0w4 215 10 transferred transfer VBN cord-333286-lr32e0w4 215 11 into into IN cord-333286-lr32e0w4 215 12 the the DT cord-333286-lr32e0w4 215 13 respiratory respiratory JJ cord-333286-lr32e0w4 215 14 tract tract NN cord-333286-lr32e0w4 215 15 via via IN cord-333286-lr32e0w4 215 16 the the DT cord-333286-lr32e0w4 215 17 gut gut NN cord-333286-lr32e0w4 215 18 - - HYPH cord-333286-lr32e0w4 215 19 respiratory respiratory JJ cord-333286-lr32e0w4 215 20 tract tract NN cord-333286-lr32e0w4 215 21 axis axis NN cord-333286-lr32e0w4 215 22 , , , cord-333286-lr32e0w4 215 23 however however RB cord-333286-lr32e0w4 215 24 , , , cord-333286-lr32e0w4 215 25 this this DT cord-333286-lr32e0w4 215 26 mechanism mechanism NN cord-333286-lr32e0w4 215 27 of of IN cord-333286-lr32e0w4 215 28 action action NN cord-333286-lr32e0w4 215 29 remains remain VBZ cord-333286-lr32e0w4 215 30 to to TO cord-333286-lr32e0w4 215 31 be be VB cord-333286-lr32e0w4 215 32 studied study VBN cord-333286-lr32e0w4 215 33 in in IN cord-333286-lr32e0w4 215 34 more more JJR cord-333286-lr32e0w4 215 35 detail detail NN cord-333286-lr32e0w4 215 36 . . . cord-333286-lr32e0w4 216 1 The the DT cord-333286-lr32e0w4 216 2 pre pre JJ cord-333286-lr32e0w4 216 3 - - JJ cord-333286-lr32e0w4 216 4 clinical clinical JJ cord-333286-lr32e0w4 216 5 studies study NNS cord-333286-lr32e0w4 216 6 further far RBR cord-333286-lr32e0w4 216 7 show show VBP cord-333286-lr32e0w4 216 8 improvement improvement NN cord-333286-lr32e0w4 216 9 in in IN cord-333286-lr32e0w4 216 10 the the DT cord-333286-lr32e0w4 216 11 symptom symptom NN cord-333286-lr32e0w4 216 12 scores score NNS cord-333286-lr32e0w4 216 13 of of IN cord-333286-lr32e0w4 216 14 mice mouse NNS cord-333286-lr32e0w4 216 15 , , , cord-333286-lr32e0w4 216 16 suggesting suggest VBG cord-333286-lr32e0w4 216 17 potential potential JJ cord-333286-lr32e0w4 216 18 clinical clinical JJ cord-333286-lr32e0w4 216 19 benefits benefit NNS cord-333286-lr32e0w4 216 20 . . . cord-333286-lr32e0w4 217 1 Indeed indeed RB cord-333286-lr32e0w4 217 2 , , , cord-333286-lr32e0w4 217 3 some some DT cord-333286-lr32e0w4 217 4 evidence evidence NN cord-333286-lr32e0w4 217 5 exists exist VBZ cord-333286-lr32e0w4 217 6 for for IN cord-333286-lr32e0w4 217 7 specific specific JJ cord-333286-lr32e0w4 217 8 probiotic probiotic JJ cord-333286-lr32e0w4 217 9 strains strain NNS cord-333286-lr32e0w4 217 10 , , , cord-333286-lr32e0w4 217 11 e.g. e.g. RB cord-333286-lr32e0w4 217 12 , , , cord-333286-lr32e0w4 217 13 from from IN cord-333286-lr32e0w4 217 14 the the DT cord-333286-lr32e0w4 217 15 species specie NNS cord-333286-lr32e0w4 217 16 of of IN cord-333286-lr32e0w4 217 17 L. L. NNP cord-333286-lr32e0w4 217 18 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 217 19 , , , cord-333286-lr32e0w4 217 20 L. L. NNP cord-333286-lr32e0w4 217 21 acidophilus acidophilus NN cord-333286-lr32e0w4 217 22 , , , cord-333286-lr32e0w4 217 23 and and CC cord-333286-lr32e0w4 217 24 B. B. NNP cord-333286-lr32e0w4 217 25 lactis lactis NNP cord-333286-lr32e0w4 217 26 for for IN cord-333286-lr32e0w4 217 27 their -PRON- PRP$ cord-333286-lr32e0w4 217 28 ability ability NN cord-333286-lr32e0w4 217 29 to to TO cord-333286-lr32e0w4 217 30 induce induce VB cord-333286-lr32e0w4 217 31 antiviral antiviral JJ cord-333286-lr32e0w4 217 32 immune immune JJ cord-333286-lr32e0w4 217 33 responses response NNS cord-333286-lr32e0w4 217 34 in in IN cord-333286-lr32e0w4 217 35 preclinical preclinical JJ cord-333286-lr32e0w4 217 36 models model NNS cord-333286-lr32e0w4 217 37 , , , cord-333286-lr32e0w4 217 38 which which WDT cord-333286-lr32e0w4 217 39 is be VBZ cord-333286-lr32e0w4 217 40 in in IN cord-333286-lr32e0w4 217 41 agreement agreement NN cord-333286-lr32e0w4 217 42 with with IN cord-333286-lr32e0w4 217 43 their -PRON- PRP$ cord-333286-lr32e0w4 217 44 effects effect NNS cord-333286-lr32e0w4 217 45 observed observe VBN cord-333286-lr32e0w4 217 46 in in IN cord-333286-lr32e0w4 217 47 clinical clinical JJ cord-333286-lr32e0w4 217 48 trials trial NNS cord-333286-lr32e0w4 217 49 in in IN cord-333286-lr32e0w4 217 50 reducing reduce VBG cord-333286-lr32e0w4 217 51 the the DT cord-333286-lr32e0w4 217 52 risk risk NN cord-333286-lr32e0w4 217 53 of of IN cord-333286-lr32e0w4 217 54 RTI RTI NNP cord-333286-lr32e0w4 217 55 - - HYPH cord-333286-lr32e0w4 217 56 associated associate VBN cord-333286-lr32e0w4 217 57 outcomes outcome NNS cord-333286-lr32e0w4 217 58 . . . cord-333286-lr32e0w4 218 1 However however RB cord-333286-lr32e0w4 218 2 , , , cord-333286-lr32e0w4 218 3 translation translation NN cord-333286-lr32e0w4 218 4 of of IN cord-333286-lr32e0w4 218 5 probiotic probiotic JJ cord-333286-lr32e0w4 218 6 effects effect NNS cord-333286-lr32e0w4 218 7 from from IN cord-333286-lr32e0w4 218 8 cell cell NN cord-333286-lr32e0w4 218 9 culture culture NN cord-333286-lr32e0w4 218 10 and and CC cord-333286-lr32e0w4 218 11 animal animal NN cord-333286-lr32e0w4 218 12 studies study NNS cord-333286-lr32e0w4 218 13 to to IN cord-333286-lr32e0w4 218 14 humans human NNS cord-333286-lr32e0w4 218 15 can can MD cord-333286-lr32e0w4 218 16 be be VB cord-333286-lr32e0w4 218 17 challenging challenging JJ cord-333286-lr32e0w4 218 18 and and CC cord-333286-lr32e0w4 218 19 variable variable JJ cord-333286-lr32e0w4 218 20 confounding confounding JJ cord-333286-lr32e0w4 218 21 factors factor NNS cord-333286-lr32e0w4 218 22 , , , cord-333286-lr32e0w4 218 23 e.g. e.g. RB cord-333286-lr32e0w4 218 24 , , , cord-333286-lr32e0w4 218 25 age age NN cord-333286-lr32e0w4 218 26 , , , cord-333286-lr32e0w4 218 27 diet diet NN cord-333286-lr32e0w4 218 28 , , , cord-333286-lr32e0w4 218 29 microbiome microbiome NN cord-333286-lr32e0w4 218 30 , , , cord-333286-lr32e0w4 218 31 genetic genetic JJ cord-333286-lr32e0w4 218 32 and and CC cord-333286-lr32e0w4 218 33 epigenetic epigenetic JJ cord-333286-lr32e0w4 218 34 immune immune JJ cord-333286-lr32e0w4 218 35 status status NN cord-333286-lr32e0w4 218 36 of of IN cord-333286-lr32e0w4 218 37 an an DT cord-333286-lr32e0w4 218 38 individual individual NN cord-333286-lr32e0w4 218 39 , , , cord-333286-lr32e0w4 218 40 study study NN cord-333286-lr32e0w4 218 41 season season NN cord-333286-lr32e0w4 218 42 , , , cord-333286-lr32e0w4 218 43 and and CC cord-333286-lr32e0w4 218 44 variable variable JJ cord-333286-lr32e0w4 218 45 viral viral JJ cord-333286-lr32e0w4 218 46 epidemiology epidemiology NN cord-333286-lr32e0w4 218 47 , , , cord-333286-lr32e0w4 218 48 all all DT cord-333286-lr32e0w4 218 49 have have VBP cord-333286-lr32e0w4 218 50 an an DT cord-333286-lr32e0w4 218 51 impact impact NN cord-333286-lr32e0w4 218 52 on on IN cord-333286-lr32e0w4 218 53 the the DT cord-333286-lr32e0w4 218 54 study study NN cord-333286-lr32e0w4 218 55 outcome outcome NN cord-333286-lr32e0w4 218 56 and and CC cord-333286-lr32e0w4 218 57 are be VBP cord-333286-lr32e0w4 218 58 difficult difficult JJ cord-333286-lr32e0w4 218 59 to to TO cord-333286-lr32e0w4 218 60 standardize standardize VB cord-333286-lr32e0w4 218 61 . . . cord-333286-lr32e0w4 219 1 The the DT cord-333286-lr32e0w4 219 2 clinical clinical JJ cord-333286-lr32e0w4 219 3 studies study NNS cord-333286-lr32e0w4 219 4 that that WDT cord-333286-lr32e0w4 219 5 have have VBP cord-333286-lr32e0w4 219 6 diagnosed diagnose VBN cord-333286-lr32e0w4 219 7 and and CC cord-333286-lr32e0w4 219 8 characterized characterize VBN cord-333286-lr32e0w4 219 9 viral viral JJ cord-333286-lr32e0w4 219 10 etiology etiology NN cord-333286-lr32e0w4 219 11 are be VBP cord-333286-lr32e0w4 219 12 limited limit VBN cord-333286-lr32e0w4 219 13 , , , cord-333286-lr32e0w4 219 14 nevertheless nevertheless RB cord-333286-lr32e0w4 219 15 , , , cord-333286-lr32e0w4 219 16 the the DT cord-333286-lr32e0w4 219 17 metaanalyses metaanalyse NNS cord-333286-lr32e0w4 219 18 investigating investigate VBG cord-333286-lr32e0w4 219 19 probiotic probiotic JJ cord-333286-lr32e0w4 219 20 clinical clinical JJ cord-333286-lr32e0w4 219 21 interventions intervention NNS cord-333286-lr32e0w4 219 22 on on IN cord-333286-lr32e0w4 219 23 RTIs rti NNS cord-333286-lr32e0w4 219 24 show show VBP cord-333286-lr32e0w4 219 25 that that IN cord-333286-lr32e0w4 219 26 probiotic probiotic JJ cord-333286-lr32e0w4 219 27 use use NN cord-333286-lr32e0w4 219 28 is be VBZ cord-333286-lr32e0w4 219 29 associated associate VBN cord-333286-lr32e0w4 219 30 with with IN cord-333286-lr32e0w4 219 31 lower low JJR cord-333286-lr32e0w4 219 32 incidence incidence NN cord-333286-lr32e0w4 219 33 and and CC cord-333286-lr32e0w4 219 34 duration duration NN cord-333286-lr32e0w4 219 35 of of IN cord-333286-lr32e0w4 219 36 mild mild JJ cord-333286-lr32e0w4 219 37 RTIs rti NNS cord-333286-lr32e0w4 219 38 , , , cord-333286-lr32e0w4 219 39 both both CC cord-333286-lr32e0w4 219 40 in in IN cord-333286-lr32e0w4 219 41 children child NNS cord-333286-lr32e0w4 219 42 and and CC cord-333286-lr32e0w4 219 43 in in IN cord-333286-lr32e0w4 219 44 adults adult NNS cord-333286-lr32e0w4 219 45 . . . cord-333286-lr32e0w4 220 1 Further further JJ cord-333286-lr32e0w4 220 2 studies study NNS cord-333286-lr32e0w4 220 3 aiming aim VBG cord-333286-lr32e0w4 220 4 at at IN cord-333286-lr32e0w4 220 5 discovering discover VBG cord-333286-lr32e0w4 220 6 the the DT cord-333286-lr32e0w4 220 7 mechanism mechanism NN cord-333286-lr32e0w4 220 8 of of IN cord-333286-lr32e0w4 220 9 action action NN cord-333286-lr32e0w4 220 10 of of IN cord-333286-lr32e0w4 220 11 probiotics probiotic NNS cord-333286-lr32e0w4 220 12 and and CC cord-333286-lr32e0w4 220 13 establishing establish VBG cord-333286-lr32e0w4 220 14 the the DT cord-333286-lr32e0w4 220 15 association association NN cord-333286-lr32e0w4 220 16 of of IN cord-333286-lr32e0w4 220 17 immune immune NNP cord-333286-lr32e0w4 220 18 system system NN cord-333286-lr32e0w4 220 19 function function VBP cord-333286-lr32e0w4 220 20 stimulation stimulation NN cord-333286-lr32e0w4 220 21 and and CC cord-333286-lr32e0w4 220 22 clinical clinical JJ cord-333286-lr32e0w4 220 23 efficacy efficacy NN cord-333286-lr32e0w4 220 24 are be VBP cord-333286-lr32e0w4 220 25 warranted warrant VBN cord-333286-lr32e0w4 220 26 . . . cord-333286-lr32e0w4 221 1 In in IN cord-333286-lr32e0w4 221 2 vitro vitro FW cord-333286-lr32e0w4 221 3 data datum NNS cord-333286-lr32e0w4 221 4 indicate indicate VBP cord-333286-lr32e0w4 221 5 that that IN cord-333286-lr32e0w4 221 6 probiotics probiotic NNS cord-333286-lr32e0w4 221 7 have have VBP cord-333286-lr32e0w4 221 8 strain strain NN cord-333286-lr32e0w4 221 9 - - HYPH cord-333286-lr32e0w4 221 10 specific specific JJ cord-333286-lr32e0w4 221 11 immunomodulatory immunomodulatory JJ cord-333286-lr32e0w4 221 12 effects effect NNS cord-333286-lr32e0w4 221 13 on on IN cord-333286-lr32e0w4 221 14 the the DT cord-333286-lr32e0w4 221 15 host host NN cord-333286-lr32e0w4 221 16 and and CC cord-333286-lr32e0w4 221 17 immune immune JJ cord-333286-lr32e0w4 221 18 cells cell NNS cord-333286-lr32e0w4 221 19 by by IN cord-333286-lr32e0w4 221 20 engaging engage VBG cord-333286-lr32e0w4 221 21 TLRs tlr NNS cord-333286-lr32e0w4 221 22 that that WDT cord-333286-lr32e0w4 221 23 stimulate stimulate VBP cord-333286-lr32e0w4 221 24 IFN IFN NNP cord-333286-lr32e0w4 221 25 pathways pathway NNS cord-333286-lr32e0w4 221 26 . . . cord-333286-lr32e0w4 222 1 The the DT cord-333286-lr32e0w4 222 2 upregulation upregulation NN cord-333286-lr32e0w4 222 3 of of IN cord-333286-lr32e0w4 222 4 IFN IFN NNP cord-333286-lr32e0w4 222 5 response response NN cord-333286-lr32e0w4 222 6 seems seem VBZ cord-333286-lr32e0w4 222 7 to to IN cord-333286-lr32e0w4 222 8 prime prime JJ cord-333286-lr32e0w4 222 9 cells cell NNS cord-333286-lr32e0w4 222 10 for for IN cord-333286-lr32e0w4 222 11 better well JJR cord-333286-lr32e0w4 222 12 resistance resistance NN cord-333286-lr32e0w4 222 13 against against IN cord-333286-lr32e0w4 222 14 virus virus NN cord-333286-lr32e0w4 222 15 infection infection NN cord-333286-lr32e0w4 222 16 as as IN cord-333286-lr32e0w4 222 17 probiotics probiotic NNS cord-333286-lr32e0w4 222 18 were be VBD cord-333286-lr32e0w4 222 19 shown show VBN cord-333286-lr32e0w4 222 20 effective effective JJ cord-333286-lr32e0w4 222 21 in in IN cord-333286-lr32e0w4 222 22 inhibiting inhibit VBG cord-333286-lr32e0w4 222 23 the the DT cord-333286-lr32e0w4 222 24 replication replication NN cord-333286-lr32e0w4 222 25 of of IN cord-333286-lr32e0w4 222 26 various various JJ cord-333286-lr32e0w4 222 27 respiratory respiratory JJ cord-333286-lr32e0w4 222 28 viruses virus NNS cord-333286-lr32e0w4 222 29 , , , cord-333286-lr32e0w4 222 30 including include VBG cord-333286-lr32e0w4 222 31 influenza influenza NN cord-333286-lr32e0w4 222 32 viruses virus NNS cord-333286-lr32e0w4 222 33 and and CC cord-333286-lr32e0w4 222 34 RSV RSV NNP cord-333286-lr32e0w4 222 35 . . . cord-333286-lr32e0w4 223 1 Similar similar JJ cord-333286-lr32e0w4 223 2 effects effect NNS cord-333286-lr32e0w4 223 3 have have VBP cord-333286-lr32e0w4 223 4 been be VBN cord-333286-lr32e0w4 223 5 demonstrated demonstrate VBN cord-333286-lr32e0w4 223 6 in in IN cord-333286-lr32e0w4 223 7 mice mouse NNS cord-333286-lr32e0w4 223 8 with with IN cord-333286-lr32e0w4 223 9 the the DT cord-333286-lr32e0w4 223 10 ability ability NN cord-333286-lr32e0w4 223 11 of of IN cord-333286-lr32e0w4 223 12 the the DT cord-333286-lr32e0w4 223 13 probiotics probiotic NNS cord-333286-lr32e0w4 223 14 to to TO cord-333286-lr32e0w4 223 15 reduce reduce VB cord-333286-lr32e0w4 223 16 virus virus NN cord-333286-lr32e0w4 223 17 titers titer NNS cord-333286-lr32e0w4 223 18 in in IN cord-333286-lr32e0w4 223 19 lung lung NN cord-333286-lr32e0w4 223 20 tissues tissue NNS cord-333286-lr32e0w4 223 21 and and CC cord-333286-lr32e0w4 223 22 to to TO cord-333286-lr32e0w4 223 23 modulate modulate VB cord-333286-lr32e0w4 223 24 antiviral antiviral JJ cord-333286-lr32e0w4 223 25 and and CC cord-333286-lr32e0w4 223 26 pro pro JJ cord-333286-lr32e0w4 223 27 - - JJ cord-333286-lr32e0w4 223 28 inflammatory inflammatory JJ cord-333286-lr32e0w4 223 29 gene gene NN cord-333286-lr32e0w4 223 30 expression expression NN cord-333286-lr32e0w4 223 31 before before IN cord-333286-lr32e0w4 223 32 and and CC cord-333286-lr32e0w4 223 33 after after IN cord-333286-lr32e0w4 223 34 viral viral JJ cord-333286-lr32e0w4 223 35 infection infection NN cord-333286-lr32e0w4 223 36 . . . cord-333286-lr32e0w4 224 1 Interestingly interestingly RB cord-333286-lr32e0w4 224 2 , , , cord-333286-lr32e0w4 224 3 some some DT cord-333286-lr32e0w4 224 4 studies study NNS cord-333286-lr32e0w4 224 5 in in IN cord-333286-lr32e0w4 224 6 mice mouse NNS cord-333286-lr32e0w4 224 7 show show VBP cord-333286-lr32e0w4 224 8 an an DT cord-333286-lr32e0w4 224 9 increase increase NN cord-333286-lr32e0w4 224 10 in in IN cord-333286-lr32e0w4 224 11 IL-10 IL-10 NNP cord-333286-lr32e0w4 224 12 response response NN cord-333286-lr32e0w4 224 13 , , , cord-333286-lr32e0w4 224 14 suggesting suggest VBG cord-333286-lr32e0w4 224 15 control control NN cord-333286-lr32e0w4 224 16 of of IN cord-333286-lr32e0w4 224 17 the the DT cord-333286-lr32e0w4 224 18 pro pro JJ cord-333286-lr32e0w4 224 19 - - JJ cord-333286-lr32e0w4 224 20 inflammatory inflammatory JJ cord-333286-lr32e0w4 224 21 response response NN cord-333286-lr32e0w4 224 22 that that WDT cord-333286-lr32e0w4 224 23 typically typically RB cord-333286-lr32e0w4 224 24 drives drive VBZ cord-333286-lr32e0w4 224 25 lung lung NN cord-333286-lr32e0w4 224 26 pathology pathology NN cord-333286-lr32e0w4 224 27 in in IN cord-333286-lr32e0w4 224 28 severe severe JJ cord-333286-lr32e0w4 224 29 infections infection NNS cord-333286-lr32e0w4 224 30 . . . cord-333286-lr32e0w4 225 1 Most Most JJS cord-333286-lr32e0w4 225 2 likely likely JJ cord-333286-lr32e0w4 225 3 probiotics probiotic NNS cord-333286-lr32e0w4 225 4 ' ' POS cord-333286-lr32e0w4 225 5 effects effect NNS cord-333286-lr32e0w4 225 6 in in IN cord-333286-lr32e0w4 225 7 the the DT cord-333286-lr32e0w4 225 8 gut gut NN cord-333286-lr32e0w4 225 9 are be VBP cord-333286-lr32e0w4 225 10 transferred transfer VBN cord-333286-lr32e0w4 225 11 into into IN cord-333286-lr32e0w4 225 12 the the DT cord-333286-lr32e0w4 225 13 respiratory respiratory JJ cord-333286-lr32e0w4 225 14 tract tract NN cord-333286-lr32e0w4 225 15 via via IN cord-333286-lr32e0w4 225 16 the the DT cord-333286-lr32e0w4 225 17 gut gut NN cord-333286-lr32e0w4 225 18 - - HYPH cord-333286-lr32e0w4 225 19 respiratory respiratory JJ cord-333286-lr32e0w4 225 20 tract tract NN cord-333286-lr32e0w4 225 21 axis axis NN cord-333286-lr32e0w4 225 22 , , , cord-333286-lr32e0w4 225 23 however however RB cord-333286-lr32e0w4 225 24 , , , cord-333286-lr32e0w4 225 25 this this DT cord-333286-lr32e0w4 225 26 mechanism mechanism NN cord-333286-lr32e0w4 225 27 of of IN cord-333286-lr32e0w4 225 28 action action NN cord-333286-lr32e0w4 225 29 remains remain VBZ cord-333286-lr32e0w4 225 30 to to TO cord-333286-lr32e0w4 225 31 be be VB cord-333286-lr32e0w4 225 32 studied study VBN cord-333286-lr32e0w4 225 33 in in IN cord-333286-lr32e0w4 225 34 more more JJR cord-333286-lr32e0w4 225 35 detail detail NN cord-333286-lr32e0w4 225 36 . . . cord-333286-lr32e0w4 226 1 The the DT cord-333286-lr32e0w4 226 2 pre pre JJ cord-333286-lr32e0w4 226 3 - - JJ cord-333286-lr32e0w4 226 4 clinical clinical JJ cord-333286-lr32e0w4 226 5 studies study NNS cord-333286-lr32e0w4 226 6 further far RBR cord-333286-lr32e0w4 226 7 show show VBP cord-333286-lr32e0w4 226 8 improvement improvement NN cord-333286-lr32e0w4 226 9 in in IN cord-333286-lr32e0w4 226 10 the the DT cord-333286-lr32e0w4 226 11 symptom symptom NN cord-333286-lr32e0w4 226 12 scores score NNS cord-333286-lr32e0w4 226 13 of of IN cord-333286-lr32e0w4 226 14 mice mouse NNS cord-333286-lr32e0w4 226 15 , , , cord-333286-lr32e0w4 226 16 suggesting suggest VBG cord-333286-lr32e0w4 226 17 potential potential JJ cord-333286-lr32e0w4 226 18 clinical clinical JJ cord-333286-lr32e0w4 226 19 benefits benefit NNS cord-333286-lr32e0w4 226 20 . . . cord-333286-lr32e0w4 227 1 Indeed indeed RB cord-333286-lr32e0w4 227 2 , , , cord-333286-lr32e0w4 227 3 some some DT cord-333286-lr32e0w4 227 4 evidence evidence NN cord-333286-lr32e0w4 227 5 exists exist VBZ cord-333286-lr32e0w4 227 6 for for IN cord-333286-lr32e0w4 227 7 specific specific JJ cord-333286-lr32e0w4 227 8 probiotic probiotic JJ cord-333286-lr32e0w4 227 9 strains strain NNS cord-333286-lr32e0w4 227 10 , , , cord-333286-lr32e0w4 227 11 e.g. e.g. RB cord-333286-lr32e0w4 227 12 , , , cord-333286-lr32e0w4 227 13 from from IN cord-333286-lr32e0w4 227 14 the the DT cord-333286-lr32e0w4 227 15 species specie NNS cord-333286-lr32e0w4 227 16 of of IN cord-333286-lr32e0w4 227 17 L. L. NNP cord-333286-lr32e0w4 227 18 rhamnosus rhamnosus NNP cord-333286-lr32e0w4 227 19 , , , cord-333286-lr32e0w4 227 20 L. L. NNP cord-333286-lr32e0w4 227 21 acidophilus acidophilus NN cord-333286-lr32e0w4 227 22 , , , cord-333286-lr32e0w4 227 23 and and CC cord-333286-lr32e0w4 227 24 B. B. NNP cord-333286-lr32e0w4 227 25 lactis lactis NNP cord-333286-lr32e0w4 227 26 for for IN cord-333286-lr32e0w4 227 27 their -PRON- PRP$ cord-333286-lr32e0w4 227 28 ability ability NN cord-333286-lr32e0w4 227 29 to to TO cord-333286-lr32e0w4 227 30 induce induce VB cord-333286-lr32e0w4 227 31 antiviral antiviral JJ cord-333286-lr32e0w4 227 32 immune immune JJ cord-333286-lr32e0w4 227 33 responses response NNS cord-333286-lr32e0w4 227 34 in in IN cord-333286-lr32e0w4 227 35 pre pre JJ cord-333286-lr32e0w4 227 36 - - JJ cord-333286-lr32e0w4 227 37 clinical clinical JJ cord-333286-lr32e0w4 227 38 models model NNS cord-333286-lr32e0w4 227 39 , , , cord-333286-lr32e0w4 227 40 which which WDT cord-333286-lr32e0w4 227 41 is be VBZ cord-333286-lr32e0w4 227 42 in in IN cord-333286-lr32e0w4 227 43 agreement agreement NN cord-333286-lr32e0w4 227 44 with with IN cord-333286-lr32e0w4 227 45 their -PRON- PRP$ cord-333286-lr32e0w4 227 46 effects effect NNS cord-333286-lr32e0w4 227 47 observed observe VBN cord-333286-lr32e0w4 227 48 in in IN cord-333286-lr32e0w4 227 49 clinical clinical JJ cord-333286-lr32e0w4 227 50 trials trial NNS cord-333286-lr32e0w4 227 51 in in IN cord-333286-lr32e0w4 227 52 reducing reduce VBG cord-333286-lr32e0w4 227 53 the the DT cord-333286-lr32e0w4 227 54 risk risk NN cord-333286-lr32e0w4 227 55 of of IN cord-333286-lr32e0w4 227 56 RTI RTI NNP cord-333286-lr32e0w4 227 57 - - HYPH cord-333286-lr32e0w4 227 58 associated associate VBN cord-333286-lr32e0w4 227 59 outcomes outcome NNS cord-333286-lr32e0w4 227 60 . . . cord-333286-lr32e0w4 228 1 However however RB cord-333286-lr32e0w4 228 2 , , , cord-333286-lr32e0w4 228 3 translation translation NN cord-333286-lr32e0w4 228 4 of of IN cord-333286-lr32e0w4 228 5 probiotic probiotic JJ cord-333286-lr32e0w4 228 6 effects effect NNS cord-333286-lr32e0w4 228 7 from from IN cord-333286-lr32e0w4 228 8 cell cell NN cord-333286-lr32e0w4 228 9 culture culture NN cord-333286-lr32e0w4 228 10 and and CC cord-333286-lr32e0w4 228 11 animal animal NN cord-333286-lr32e0w4 228 12 studies study NNS cord-333286-lr32e0w4 228 13 to to IN cord-333286-lr32e0w4 228 14 humans human NNS cord-333286-lr32e0w4 228 15 can can MD cord-333286-lr32e0w4 228 16 be be VB cord-333286-lr32e0w4 228 17 challenging challenging JJ cord-333286-lr32e0w4 228 18 and and CC cord-333286-lr32e0w4 228 19 variable variable JJ cord-333286-lr32e0w4 228 20 confounding confounding JJ cord-333286-lr32e0w4 228 21 factors factor NNS cord-333286-lr32e0w4 228 22 , , , cord-333286-lr32e0w4 228 23 e.g. e.g. RB cord-333286-lr32e0w4 228 24 , , , cord-333286-lr32e0w4 228 25 age age NN cord-333286-lr32e0w4 228 26 , , , cord-333286-lr32e0w4 228 27 diet diet NN cord-333286-lr32e0w4 228 28 , , , cord-333286-lr32e0w4 228 29 microbiome microbiome NN cord-333286-lr32e0w4 228 30 , , , cord-333286-lr32e0w4 228 31 genetic genetic JJ cord-333286-lr32e0w4 228 32 and and CC cord-333286-lr32e0w4 228 33 epigenetic epigenetic JJ cord-333286-lr32e0w4 228 34 immune immune JJ cord-333286-lr32e0w4 228 35 status status NN cord-333286-lr32e0w4 228 36 of of IN cord-333286-lr32e0w4 228 37 an an DT cord-333286-lr32e0w4 228 38 individual individual NN cord-333286-lr32e0w4 228 39 , , , cord-333286-lr32e0w4 228 40 study study NN cord-333286-lr32e0w4 228 41 season season NN cord-333286-lr32e0w4 228 42 , , , cord-333286-lr32e0w4 228 43 and and CC cord-333286-lr32e0w4 228 44 variable variable JJ cord-333286-lr32e0w4 228 45 viral viral JJ cord-333286-lr32e0w4 228 46 epidemiology epidemiology NN cord-333286-lr32e0w4 228 47 , , , cord-333286-lr32e0w4 228 48 all all DT cord-333286-lr32e0w4 228 49 have have VBP cord-333286-lr32e0w4 228 50 an an DT cord-333286-lr32e0w4 228 51 impact impact NN cord-333286-lr32e0w4 228 52 on on IN cord-333286-lr32e0w4 228 53 the the DT cord-333286-lr32e0w4 228 54 study study NN cord-333286-lr32e0w4 228 55 outcome outcome NN cord-333286-lr32e0w4 228 56 and and CC cord-333286-lr32e0w4 228 57 are be VBP cord-333286-lr32e0w4 228 58 difficult difficult JJ cord-333286-lr32e0w4 228 59 to to TO cord-333286-lr32e0w4 228 60 standardize standardize VB cord-333286-lr32e0w4 228 61 . . . cord-333286-lr32e0w4 229 1 The the DT cord-333286-lr32e0w4 229 2 clinical clinical JJ cord-333286-lr32e0w4 229 3 studies study NNS cord-333286-lr32e0w4 229 4 that that WDT cord-333286-lr32e0w4 229 5 have have VBP cord-333286-lr32e0w4 229 6 diagnosed diagnose VBN cord-333286-lr32e0w4 229 7 and and CC cord-333286-lr32e0w4 229 8 characterized characterize VBN cord-333286-lr32e0w4 229 9 viral viral JJ cord-333286-lr32e0w4 229 10 etiology etiology NN cord-333286-lr32e0w4 229 11 are be VBP cord-333286-lr32e0w4 229 12 limited limit VBN cord-333286-lr32e0w4 229 13 , , , cord-333286-lr32e0w4 229 14 nevertheless nevertheless RB cord-333286-lr32e0w4 229 15 , , , cord-333286-lr32e0w4 229 16 the the DT cord-333286-lr32e0w4 229 17 meta meta NNP cord-333286-lr32e0w4 229 18 - - HYPH cord-333286-lr32e0w4 229 19 analyses analysis NNS cord-333286-lr32e0w4 229 20 investigating investigate VBG cord-333286-lr32e0w4 229 21 probiotic probiotic JJ cord-333286-lr32e0w4 229 22 clinical clinical JJ cord-333286-lr32e0w4 229 23 interventions intervention NNS cord-333286-lr32e0w4 229 24 on on IN cord-333286-lr32e0w4 229 25 RTIs rti NNS cord-333286-lr32e0w4 229 26 show show VBP cord-333286-lr32e0w4 229 27 that that IN cord-333286-lr32e0w4 229 28 probiotic probiotic JJ cord-333286-lr32e0w4 229 29 use use NN cord-333286-lr32e0w4 229 30 is be VBZ cord-333286-lr32e0w4 229 31 associated associate VBN cord-333286-lr32e0w4 229 32 with with IN cord-333286-lr32e0w4 229 33 lower low JJR cord-333286-lr32e0w4 229 34 incidence incidence NN cord-333286-lr32e0w4 229 35 and and CC cord-333286-lr32e0w4 229 36 duration duration NN cord-333286-lr32e0w4 229 37 of of IN cord-333286-lr32e0w4 229 38 mild mild JJ cord-333286-lr32e0w4 229 39 RTIs rti NNS cord-333286-lr32e0w4 229 40 , , , cord-333286-lr32e0w4 229 41 both both CC cord-333286-lr32e0w4 229 42 in in IN cord-333286-lr32e0w4 229 43 children child NNS cord-333286-lr32e0w4 229 44 and and CC cord-333286-lr32e0w4 229 45 in in IN cord-333286-lr32e0w4 229 46 adults adult NNS cord-333286-lr32e0w4 229 47 . . . cord-333286-lr32e0w4 230 1 Further further JJ cord-333286-lr32e0w4 230 2 studies study NNS cord-333286-lr32e0w4 230 3 aiming aim VBG cord-333286-lr32e0w4 230 4 at at IN cord-333286-lr32e0w4 230 5 discovering discover VBG cord-333286-lr32e0w4 230 6 the the DT cord-333286-lr32e0w4 230 7 mechanism mechanism NN cord-333286-lr32e0w4 230 8 of of IN cord-333286-lr32e0w4 230 9 action action NN cord-333286-lr32e0w4 230 10 of of IN cord-333286-lr32e0w4 230 11 probiotics probiotic NNS cord-333286-lr32e0w4 230 12 and and CC cord-333286-lr32e0w4 230 13 establishing establish VBG cord-333286-lr32e0w4 230 14 the the DT cord-333286-lr32e0w4 230 15 association association NN cord-333286-lr32e0w4 230 16 of of IN cord-333286-lr32e0w4 230 17 immune immune NNP cord-333286-lr32e0w4 230 18 system system NN cord-333286-lr32e0w4 230 19 function function VBP cord-333286-lr32e0w4 230 20 stimulation stimulation NN cord-333286-lr32e0w4 230 21 and and CC cord-333286-lr32e0w4 230 22 clinical clinical JJ cord-333286-lr32e0w4 230 23 efficacy efficacy NN cord-333286-lr32e0w4 230 24 are be VBP cord-333286-lr32e0w4 230 25 warranted warrant VBN cord-333286-lr32e0w4 230 26 . . . cord-333286-lr32e0w4 230 27 _SP cord-333286-lr32e0w4 231 1 The the DT cord-333286-lr32e0w4 231 2 common common JJ cord-333286-lr32e0w4 231 3 cold cold JJ cord-333286-lr32e0w4 231 4 Epidemiology epidemiology NN cord-333286-lr32e0w4 231 5 of of IN cord-333286-lr32e0w4 231 6 Viral Viral NNP cord-333286-lr32e0w4 231 7 Pneumonia Pneumonia NNP cord-333286-lr32e0w4 231 8 . . . cord-333286-lr32e0w4 232 1 Clin Clin NNP cord-333286-lr32e0w4 232 2 Microbiome Microbiome NNP cord-333286-lr32e0w4 232 3 and and CC cord-333286-lr32e0w4 232 4 disease disease NN cord-333286-lr32e0w4 232 5 in in IN cord-333286-lr32e0w4 232 6 the the DT cord-333286-lr32e0w4 232 7 upper upper JJ cord-333286-lr32e0w4 232 8 airway airway NN cord-333286-lr32e0w4 233 1 The the DT cord-333286-lr32e0w4 233 2 influence influence NN cord-333286-lr32e0w4 233 3 of of IN cord-333286-lr32e0w4 233 4 the the DT cord-333286-lr32e0w4 233 5 microbiome microbiome NN cord-333286-lr32e0w4 233 6 on on IN cord-333286-lr32e0w4 233 7 respiratory respiratory JJ cord-333286-lr32e0w4 233 8 health health NN cord-333286-lr32e0w4 233 9 Probiotics probiotic NNS cord-333286-lr32e0w4 233 10 for for IN cord-333286-lr32e0w4 233 11 preventing prevent VBG cord-333286-lr32e0w4 233 12 acute acute JJ cord-333286-lr32e0w4 233 13 upper upper JJ cord-333286-lr32e0w4 233 14 respiratory respiratory JJ cord-333286-lr32e0w4 233 15 tract tract NN cord-333286-lr32e0w4 233 16 infections infection NNS cord-333286-lr32e0w4 233 17 Probiotics probiotic NNS cord-333286-lr32e0w4 233 18 for for IN cord-333286-lr32e0w4 233 19 preventing prevent VBG cord-333286-lr32e0w4 233 20 acute acute JJ cord-333286-lr32e0w4 233 21 upper upper JJ cord-333286-lr32e0w4 233 22 respiratory respiratory JJ cord-333286-lr32e0w4 233 23 tract tract NN cord-333286-lr32e0w4 233 24 infections infection NNS cord-333286-lr32e0w4 233 25 Respiratory respiratory JJ cord-333286-lr32e0w4 233 26 virus virus NN cord-333286-lr32e0w4 233 27 infections infection NNS cord-333286-lr32e0w4 233 28 Emerging emerge VBG cord-333286-lr32e0w4 233 29 respiratory respiratory JJ cord-333286-lr32e0w4 233 30 viruses virus NNS cord-333286-lr32e0w4 233 31 other other JJ cord-333286-lr32e0w4 233 32 than than IN cord-333286-lr32e0w4 233 33 influenza influenza NN cord-333286-lr32e0w4 233 34 SARS SARS NNP cord-333286-lr32e0w4 233 35 - - HYPH cord-333286-lr32e0w4 233 36 CoV-2 CoV-2 NNP cord-333286-lr32e0w4 233 37 Viral Viral NNP cord-333286-lr32e0w4 233 38 Load Load NNP cord-333286-lr32e0w4 233 39 in in IN cord-333286-lr32e0w4 233 40 Upper Upper NNP cord-333286-lr32e0w4 233 41 Respiratory respiratory JJ cord-333286-lr32e0w4 233 42 Specimens specimen NNS cord-333286-lr32e0w4 233 43 of of IN cord-333286-lr32e0w4 233 44 Infected infected JJ cord-333286-lr32e0w4 233 45 Patients Patients NNPS cord-333286-lr32e0w4 233 46 Epidemiology Epidemiology NNP cord-333286-lr32e0w4 233 47 of of IN cord-333286-lr32e0w4 233 48 viral viral JJ cord-333286-lr32e0w4 233 49 respiratory respiratory JJ cord-333286-lr32e0w4 233 50 infections infection NNS cord-333286-lr32e0w4 234 1 Epidemiologic epidemiologic JJ cord-333286-lr32e0w4 234 2 , , , cord-333286-lr32e0w4 234 3 clinical clinical JJ cord-333286-lr32e0w4 234 4 , , , cord-333286-lr32e0w4 234 5 and and CC cord-333286-lr32e0w4 234 6 virologic virologic JJ cord-333286-lr32e0w4 234 7 characteristics characteristic NNS cord-333286-lr32e0w4 234 8 of of IN cord-333286-lr32e0w4 234 9 human human JJ cord-333286-lr32e0w4 234 10 rhinovirus rhinovirus NN cord-333286-lr32e0w4 234 11 infection infection NN cord-333286-lr32e0w4 234 12 among among IN cord-333286-lr32e0w4 234 13 otherwise otherwise RB cord-333286-lr32e0w4 234 14 healthy healthy JJ cord-333286-lr32e0w4 234 15 children child NNS cord-333286-lr32e0w4 234 16 and and CC cord-333286-lr32e0w4 234 17 adults adult NNS cord-333286-lr32e0w4 234 18 : : : cord-333286-lr32e0w4 235 1 Rhinovirus rhinovirus NN cord-333286-lr32e0w4 235 2 among among IN cord-333286-lr32e0w4 235 3 adults adult NNS cord-333286-lr32e0w4 235 4 and and CC cord-333286-lr32e0w4 235 5 children child NNS cord-333286-lr32e0w4 235 6 Pathogenesis Pathogenesis NNP cord-333286-lr32e0w4 235 7 of of IN cord-333286-lr32e0w4 235 8 rhinovirus rhinovirus NN cord-333286-lr32e0w4 235 9 infection infection NN cord-333286-lr32e0w4 236 1 Nasal nasal NN cord-333286-lr32e0w4 236 2 microbiota microbiota NN cord-333286-lr32e0w4 236 3 clusters cluster NNS cord-333286-lr32e0w4 236 4 associate associate VBP cord-333286-lr32e0w4 236 5 with with IN cord-333286-lr32e0w4 236 6 inflammatory inflammatory JJ cord-333286-lr32e0w4 236 7 response response NN cord-333286-lr32e0w4 236 8 , , , cord-333286-lr32e0w4 236 9 viral viral JJ cord-333286-lr32e0w4 236 10 load load NN cord-333286-lr32e0w4 236 11 , , , cord-333286-lr32e0w4 236 12 and and CC cord-333286-lr32e0w4 236 13 symptom symptom NN cord-333286-lr32e0w4 236 14 severity severity NN cord-333286-lr32e0w4 236 15 in in IN cord-333286-lr32e0w4 236 16 experimental experimental JJ cord-333286-lr32e0w4 236 17 rhinovirus rhinovirus NN cord-333286-lr32e0w4 236 18 challenge challenge NN cord-333286-lr32e0w4 236 19 Mechanisms Mechanisms NNPS cord-333286-lr32e0w4 236 20 of of IN cord-333286-lr32e0w4 236 21 viral viral JJ cord-333286-lr32e0w4 236 22 mutation mutation NN cord-333286-lr32e0w4 236 23 Viral viral JJ cord-333286-lr32e0w4 236 24 manipulation manipulation NN cord-333286-lr32e0w4 236 25 of of IN cord-333286-lr32e0w4 236 26 the the DT cord-333286-lr32e0w4 236 27 host host NN cord-333286-lr32e0w4 236 28 immune immune JJ cord-333286-lr32e0w4 236 29 response response NN cord-333286-lr32e0w4 236 30 Transmission transmission NN cord-333286-lr32e0w4 236 31 routes route NNS cord-333286-lr32e0w4 236 32 of of IN cord-333286-lr32e0w4 236 33 respiratory respiratory JJ cord-333286-lr32e0w4 236 34 viruses virus NNS cord-333286-lr32e0w4 236 35 among among IN cord-333286-lr32e0w4 236 36 humans human NNS cord-333286-lr32e0w4 236 37 Epithelial epithelial JJ cord-333286-lr32e0w4 236 38 cells cell NNS cord-333286-lr32e0w4 236 39 and and CC cord-333286-lr32e0w4 236 40 airway airway NN cord-333286-lr32e0w4 236 41 diseases disease NNS cord-333286-lr32e0w4 237 1 The the DT cord-333286-lr32e0w4 237 2 host host NN cord-333286-lr32e0w4 237 3 immune immune JJ cord-333286-lr32e0w4 237 4 response response NN cord-333286-lr32e0w4 237 5 in in IN cord-333286-lr32e0w4 237 6 respiratory respiratory JJ cord-333286-lr32e0w4 237 7 virus virus NN cord-333286-lr32e0w4 237 8 infection infection NN cord-333286-lr32e0w4 237 9 : : : cord-333286-lr32e0w4 237 10 Balancing balance VBG cord-333286-lr32e0w4 237 11 virus virus NN cord-333286-lr32e0w4 237 12 clearance clearance NN cord-333286-lr32e0w4 237 13 and and CC cord-333286-lr32e0w4 237 14 immunopathology immunopathology NN cord-333286-lr32e0w4 238 1 The the DT cord-333286-lr32e0w4 238 2 morphology morphology NN cord-333286-lr32e0w4 238 3 of of IN cord-333286-lr32e0w4 238 4 virus virus NN cord-333286-lr32e0w4 238 5 particles particle NNS cord-333286-lr32e0w4 238 6 . . . cord-333286-lr32e0w4 239 1 Classification classification NN cord-333286-lr32e0w4 239 2 of of IN cord-333286-lr32e0w4 239 3 viruses virus NNS cord-333286-lr32e0w4 240 1 Immune immune JJ cord-333286-lr32e0w4 240 2 responses response NNS cord-333286-lr32e0w4 240 3 to to IN cord-333286-lr32e0w4 240 4 influenza influenza NN cord-333286-lr32e0w4 240 5 virus virus NN cord-333286-lr32e0w4 240 6 infection infection NN cord-333286-lr32e0w4 240 7 SARS SARS NNP cord-333286-lr32e0w4 240 8 coronavirus coronavirus NN cord-333286-lr32e0w4 240 9 pathogenesis pathogenesis NN cord-333286-lr32e0w4 240 10 : : : cord-333286-lr32e0w4 241 1 Host host NN cord-333286-lr32e0w4 241 2 innate innate JJ cord-333286-lr32e0w4 241 3 immune immune JJ cord-333286-lr32e0w4 241 4 responses response NNS cord-333286-lr32e0w4 241 5 and and CC cord-333286-lr32e0w4 241 6 viral viral JJ cord-333286-lr32e0w4 241 7 antagonism antagonism NN cord-333286-lr32e0w4 241 8 of of IN cord-333286-lr32e0w4 241 9 interferon interferon NN cord-333286-lr32e0w4 241 10 Pathogenesis Pathogenesis NNP cord-333286-lr32e0w4 241 11 of of IN cord-333286-lr32e0w4 241 12 influenza influenza NN cord-333286-lr32e0w4 241 13 virus virus NN cord-333286-lr32e0w4 241 14 infections infection NNS cord-333286-lr32e0w4 241 15 : : : cord-333286-lr32e0w4 241 16 The the DT cord-333286-lr32e0w4 241 17 good good NN cord-333286-lr32e0w4 241 18 , , , cord-333286-lr32e0w4 241 19 the the DT cord-333286-lr32e0w4 241 20 bad bad JJ cord-333286-lr32e0w4 241 21 and and CC cord-333286-lr32e0w4 241 22 the the DT cord-333286-lr32e0w4 241 23 ugly ugly JJ cord-333286-lr32e0w4 241 24 Inflammasome Inflammasome NNP cord-333286-lr32e0w4 241 25 control control NN cord-333286-lr32e0w4 241 26 of of IN cord-333286-lr32e0w4 241 27 viral viral JJ cord-333286-lr32e0w4 241 28 infection infection NN cord-333286-lr32e0w4 242 1 The the DT cord-333286-lr32e0w4 242 2 NLRP3 nlrp3 NN cord-333286-lr32e0w4 242 3 inflammasome inflammasome NN cord-333286-lr32e0w4 242 4 : : : cord-333286-lr32e0w4 243 1 Molecular molecular JJ cord-333286-lr32e0w4 243 2 activation activation NN cord-333286-lr32e0w4 243 3 and and CC cord-333286-lr32e0w4 243 4 regulation regulation NN cord-333286-lr32e0w4 243 5 to to IN cord-333286-lr32e0w4 243 6 therapeutics therapeutic NNS cord-333286-lr32e0w4 243 7 Cytokine cytokine NN cord-333286-lr32e0w4 243 8 Networks Networks NNP cord-333286-lr32e0w4 243 9 between between IN cord-333286-lr32e0w4 243 10 Innate Innate NNP cord-333286-lr32e0w4 243 11 Lymphoid Lymphoid NNP cord-333286-lr32e0w4 243 12 Cells Cells NNPS cord-333286-lr32e0w4 243 13 and and CC cord-333286-lr32e0w4 243 14 Myeloid Myeloid NNP cord-333286-lr32e0w4 243 15 Cells cell NNS cord-333286-lr32e0w4 244 1 Early early JJ cord-333286-lr32e0w4 244 2 local local JJ cord-333286-lr32e0w4 244 3 immune immune JJ cord-333286-lr32e0w4 244 4 defences defence NNS cord-333286-lr32e0w4 244 5 in in IN cord-333286-lr32e0w4 244 6 the the DT cord-333286-lr32e0w4 244 7 respiratory respiratory JJ cord-333286-lr32e0w4 244 8 tract tract NN cord-333286-lr32e0w4 244 9 Group Group NNP cord-333286-lr32e0w4 244 10 2 2 CD cord-333286-lr32e0w4 244 11 Innate Innate NNP cord-333286-lr32e0w4 244 12 Lymphoid Lymphoid NNP cord-333286-lr32e0w4 244 13 Cell Cell NNP cord-333286-lr32e0w4 244 14 Production production NN cord-333286-lr32e0w4 244 15 of of IN cord-333286-lr32e0w4 245 1 IL-5 IL-5 NNP cord-333286-lr32e0w4 245 2 Is be VBZ cord-333286-lr32e0w4 245 3 Regulated regulate VBN cord-333286-lr32e0w4 245 4 by by IN cord-333286-lr32e0w4 245 5 NKT NKT NNP cord-333286-lr32e0w4 245 6 Cells Cells NNPS cord-333286-lr32e0w4 245 7 during during IN cord-333286-lr32e0w4 245 8 Influenza Influenza NNP cord-333286-lr32e0w4 245 9 Virus Virus NNP cord-333286-lr32e0w4 245 10 Infection Infection NNP cord-333286-lr32e0w4 245 11 Protective Protective NNP cord-333286-lr32e0w4 245 12 and and CC cord-333286-lr32e0w4 245 13 Harmful harmful JJ cord-333286-lr32e0w4 245 14 Immunity immunity NN cord-333286-lr32e0w4 245 15 to to IN cord-333286-lr32e0w4 245 16 RSV RSV NNP cord-333286-lr32e0w4 245 17 Infection infection NN cord-333286-lr32e0w4 246 1 The the DT cord-333286-lr32e0w4 246 2 CD8 CD8 NNP cord-333286-lr32e0w4 246 3 T T NNP cord-333286-lr32e0w4 246 4 Cell Cell NNP cord-333286-lr32e0w4 246 5 Response response NN cord-333286-lr32e0w4 246 6 to to IN cord-333286-lr32e0w4 246 7 Respiratory respiratory JJ cord-333286-lr32e0w4 246 8 Virus Virus NNP cord-333286-lr32e0w4 246 9 Infections Infections NNPS cord-333286-lr32e0w4 246 10 Host Host NNP cord-333286-lr32e0w4 246 11 defense defense NN cord-333286-lr32e0w4 246 12 function function NN cord-333286-lr32e0w4 246 13 of of IN cord-333286-lr32e0w4 246 14 the the DT cord-333286-lr32e0w4 246 15 airway airway NN cord-333286-lr32e0w4 246 16 epithelium epithelium NN cord-333286-lr32e0w4 246 17 in in IN cord-333286-lr32e0w4 246 18 health health NN cord-333286-lr32e0w4 246 19 and and CC cord-333286-lr32e0w4 246 20 disease disease NN cord-333286-lr32e0w4 246 21 : : : cord-333286-lr32e0w4 247 1 Clinical clinical JJ cord-333286-lr32e0w4 247 2 background background NN cord-333286-lr32e0w4 247 3 Immunopathology Immunopathology NNP cord-333286-lr32e0w4 247 4 in in IN cord-333286-lr32e0w4 247 5 influenza influenza NN cord-333286-lr32e0w4 247 6 virus virus NN cord-333286-lr32e0w4 247 7 infection infection NN cord-333286-lr32e0w4 247 8 : : : cord-333286-lr32e0w4 247 9 Uncoupling uncouple VBG cord-333286-lr32e0w4 247 10 the the DT cord-333286-lr32e0w4 247 11 friend friend NN cord-333286-lr32e0w4 247 12 from from IN cord-333286-lr32e0w4 247 13 foe foe NN cord-333286-lr32e0w4 247 14 The the DT cord-333286-lr32e0w4 247 15 trinity trinity NN cord-333286-lr32e0w4 247 16 of of IN cord-333286-lr32e0w4 247 17 COVID-19 COVID-19 NNP cord-333286-lr32e0w4 247 18 : : : cord-333286-lr32e0w4 247 19 Immunity immunity NN cord-333286-lr32e0w4 247 20 , , , cord-333286-lr32e0w4 247 21 inflammation inflammation NN cord-333286-lr32e0w4 247 22 and and CC cord-333286-lr32e0w4 247 23 intervention intervention NN cord-333286-lr32e0w4 247 24 Relationship relationship NN cord-333286-lr32e0w4 247 25 of of IN cord-333286-lr32e0w4 247 26 upper upper JJ cord-333286-lr32e0w4 247 27 and and CC cord-333286-lr32e0w4 247 28 lower low JJR cord-333286-lr32e0w4 247 29 airway airway NN cord-333286-lr32e0w4 247 30 cytokines cytokine NNS cord-333286-lr32e0w4 247 31 to to TO cord-333286-lr32e0w4 247 32 outcome outcome VB cord-333286-lr32e0w4 247 33 of of IN cord-333286-lr32e0w4 247 34 experimental experimental JJ cord-333286-lr32e0w4 247 35 rhinovirus rhinovirus NN cord-333286-lr32e0w4 247 36 infection infection NN cord-333286-lr32e0w4 247 37 Role role NN cord-333286-lr32e0w4 247 38 of of IN cord-333286-lr32e0w4 247 39 nasal nasal NN cord-333286-lr32e0w4 247 40 interleukin-8 interleukin-8 NNP cord-333286-lr32e0w4 247 41 in in IN cord-333286-lr32e0w4 247 42 neutrophil neutrophil NN cord-333286-lr32e0w4 247 43 recruitment recruitment NN cord-333286-lr32e0w4 247 44 and and CC cord-333286-lr32e0w4 247 45 activation activation NN cord-333286-lr32e0w4 247 46 in in IN cord-333286-lr32e0w4 247 47 children child NNS cord-333286-lr32e0w4 247 48 with with IN cord-333286-lr32e0w4 247 49 virus virus NN cord-333286-lr32e0w4 247 50 - - HYPH cord-333286-lr32e0w4 247 51 induced induce VBN cord-333286-lr32e0w4 247 52 asthma asthma NN cord-333286-lr32e0w4 247 53 Elevated elevated JJ cord-333286-lr32e0w4 247 54 levels level NNS cord-333286-lr32e0w4 247 55 of of IN cord-333286-lr32e0w4 247 56 interleukins interleukin NNS cord-333286-lr32e0w4 248 1 IL-1 IL-1 NNP cord-333286-lr32e0w4 248 2 beta beta NN cord-333286-lr32e0w4 248 3 , , , cord-333286-lr32e0w4 248 4 IL-6 IL-6 NNP cord-333286-lr32e0w4 248 5 and and CC cord-333286-lr32e0w4 248 6 IL-8 IL-8 NNP cord-333286-lr32e0w4 248 7 in in RB cord-333286-lr32e0w4 248 8 naturally naturally RB cord-333286-lr32e0w4 248 9 acquired acquire VBN cord-333286-lr32e0w4 248 10 viral viral JJ cord-333286-lr32e0w4 248 11 rhinitis rhinitis NN cord-333286-lr32e0w4 248 12 Symptom symptom NN cord-333286-lr32e0w4 248 13 pathogenesis pathogenesis NN cord-333286-lr32e0w4 248 14 during during IN cord-333286-lr32e0w4 248 15 acute acute JJ cord-333286-lr32e0w4 248 16 influenza influenza NN cord-333286-lr32e0w4 248 17 : : : cord-333286-lr32e0w4 248 18 Interleukin-6 Interleukin-6 NNP cord-333286-lr32e0w4 248 19 and and CC cord-333286-lr32e0w4 248 20 other other JJ cord-333286-lr32e0w4 248 21 cytokine cytokine NN cord-333286-lr32e0w4 248 22 responses response NNS cord-333286-lr32e0w4 249 1 A a DT cord-333286-lr32e0w4 249 2 Distinct distinct JJ cord-333286-lr32e0w4 249 3 Function function NN cord-333286-lr32e0w4 249 4 of of IN cord-333286-lr32e0w4 249 5 Regulatory Regulatory NNP cord-333286-lr32e0w4 249 6 T T NNP cord-333286-lr32e0w4 249 7 Cells Cells NNPS cord-333286-lr32e0w4 249 8 in in IN cord-333286-lr32e0w4 249 9 Tissue Tissue NNP cord-333286-lr32e0w4 249 10 Protection Protection NNP cord-333286-lr32e0w4 249 11 Effector Effector NNP cord-333286-lr32e0w4 249 12 T T NNP cord-333286-lr32e0w4 249 13 cells cell NNS cord-333286-lr32e0w4 249 14 control control VBP cord-333286-lr32e0w4 249 15 lung lung NN cord-333286-lr32e0w4 249 16 inflammation inflammation NN cord-333286-lr32e0w4 249 17 during during IN cord-333286-lr32e0w4 249 18 acute acute JJ cord-333286-lr32e0w4 249 19 influenza influenza NN cord-333286-lr32e0w4 249 20 virus virus NN cord-333286-lr32e0w4 249 21 infection infection NN cord-333286-lr32e0w4 249 22 by by IN cord-333286-lr32e0w4 249 23 producing produce VBG cord-333286-lr32e0w4 249 24 IL-10 IL-10 NNP cord-333286-lr32e0w4 249 25 The the DT cord-333286-lr32e0w4 249 26 role role NN cord-333286-lr32e0w4 249 27 of of IN cord-333286-lr32e0w4 249 28 pro pro JJ cord-333286-lr32e0w4 249 29 - - JJ cord-333286-lr32e0w4 249 30 resolution resolution JJ cord-333286-lr32e0w4 249 31 lipid lipid NN cord-333286-lr32e0w4 249 32 mediators mediator NNS cord-333286-lr32e0w4 249 33 in in IN cord-333286-lr32e0w4 249 34 infectious infectious JJ cord-333286-lr32e0w4 249 35 disease disease NN cord-333286-lr32e0w4 249 36 Expert Expert NNP cord-333286-lr32e0w4 249 37 consensus consensus NN cord-333286-lr32e0w4 249 38 document document NN cord-333286-lr32e0w4 249 39 . . . cord-333286-lr32e0w4 250 1 The the DT cord-333286-lr32e0w4 250 2 International International NNP cord-333286-lr32e0w4 250 3 Scientific Scientific NNP cord-333286-lr32e0w4 250 4 Association Association NNP cord-333286-lr32e0w4 250 5 for for IN cord-333286-lr32e0w4 250 6 Probiotics Probiotics NNPS cord-333286-lr32e0w4 250 7 and and CC cord-333286-lr32e0w4 250 8 Prebiotics Prebiotics NNP cord-333286-lr32e0w4 250 9 consensus consensus NN cord-333286-lr32e0w4 250 10 statement statement NN cord-333286-lr32e0w4 250 11 on on IN cord-333286-lr32e0w4 250 12 the the DT cord-333286-lr32e0w4 250 13 scope scope NN cord-333286-lr32e0w4 250 14 and and CC cord-333286-lr32e0w4 250 15 appropriate appropriate JJ cord-333286-lr32e0w4 250 16 use use NN cord-333286-lr32e0w4 250 17 of of IN cord-333286-lr32e0w4 250 18 the the DT cord-333286-lr32e0w4 250 19 term term NN cord-333286-lr32e0w4 250 20 probiotic probiotic JJ cord-333286-lr32e0w4 250 21 A a DT cord-333286-lr32e0w4 250 22 taxonomic taxonomic JJ cord-333286-lr32e0w4 250 23 note note NN cord-333286-lr32e0w4 250 24 on on IN cord-333286-lr32e0w4 250 25 the the DT cord-333286-lr32e0w4 250 26 genus genus NN cord-333286-lr32e0w4 250 27 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 250 28 : : : cord-333286-lr32e0w4 250 29 Description description NN cord-333286-lr32e0w4 250 30 of of IN cord-333286-lr32e0w4 250 31 23 23 CD cord-333286-lr32e0w4 250 32 novel novel JJ cord-333286-lr32e0w4 250 33 genera genus NNS cord-333286-lr32e0w4 250 34 , , , cord-333286-lr32e0w4 250 35 emended emended JJ cord-333286-lr32e0w4 250 36 description description NN cord-333286-lr32e0w4 250 37 of of IN cord-333286-lr32e0w4 250 38 the the DT cord-333286-lr32e0w4 250 39 genus genus NN cord-333286-lr32e0w4 250 40 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 250 41 Beijerinck Beijerinck NNP cord-333286-lr32e0w4 250 42 1901 1901 CD cord-333286-lr32e0w4 250 43 , , , cord-333286-lr32e0w4 250 44 and and CC cord-333286-lr32e0w4 250 45 union union NN cord-333286-lr32e0w4 250 46 of of IN cord-333286-lr32e0w4 250 47 Lactobacillaceae Lactobacillaceae NNP cord-333286-lr32e0w4 250 48 and and CC cord-333286-lr32e0w4 250 49 Leuconostocaceae Leuconostocaceae NNP cord-333286-lr32e0w4 250 50 Absence absence NN cord-333286-lr32e0w4 250 51 of of IN cord-333286-lr32e0w4 250 52 adverse adverse JJ cord-333286-lr32e0w4 250 53 events event NNS cord-333286-lr32e0w4 250 54 in in IN cord-333286-lr32e0w4 250 55 healthy healthy JJ cord-333286-lr32e0w4 250 56 individuals individual NNS cord-333286-lr32e0w4 250 57 using use VBG cord-333286-lr32e0w4 250 58 probiotics probiotic NNS cord-333286-lr32e0w4 250 59 - - HYPH cord-333286-lr32e0w4 250 60 Analysis Analysis NNP cord-333286-lr32e0w4 250 61 of of IN cord-333286-lr32e0w4 250 62 six six CD cord-333286-lr32e0w4 250 63 randomised randomised JJ cord-333286-lr32e0w4 250 64 studies study NNS cord-333286-lr32e0w4 250 65 by by IN cord-333286-lr32e0w4 250 66 one one CD cord-333286-lr32e0w4 250 67 study study NN cord-333286-lr32e0w4 250 68 group group NN cord-333286-lr32e0w4 250 69 A a DT cord-333286-lr32e0w4 250 70 systematic systematic JJ cord-333286-lr32e0w4 250 71 review review NN cord-333286-lr32e0w4 250 72 of of IN cord-333286-lr32e0w4 250 73 the the DT cord-333286-lr32e0w4 250 74 safety safety NN cord-333286-lr32e0w4 250 75 of of IN cord-333286-lr32e0w4 250 76 probiotics probiotics NNP cord-333286-lr32e0w4 250 77 Safety Safety NNP cord-333286-lr32e0w4 250 78 assessment assessment NN cord-333286-lr32e0w4 250 79 of of IN cord-333286-lr32e0w4 250 80 probiotics probiotic NNS cord-333286-lr32e0w4 250 81 for for IN cord-333286-lr32e0w4 250 82 human human JJ cord-333286-lr32e0w4 250 83 use use NN cord-333286-lr32e0w4 250 84 Effectiveness Effectiveness NNP cord-333286-lr32e0w4 250 85 of of IN cord-333286-lr32e0w4 250 86 probiotics probiotic NNS cord-333286-lr32e0w4 250 87 on on IN cord-333286-lr32e0w4 250 88 the the DT cord-333286-lr32e0w4 250 89 duration duration NN cord-333286-lr32e0w4 250 90 of of IN cord-333286-lr32e0w4 250 91 illness illness NN cord-333286-lr32e0w4 250 92 in in IN cord-333286-lr32e0w4 250 93 healthy healthy JJ cord-333286-lr32e0w4 250 94 children child NNS cord-333286-lr32e0w4 250 95 and and CC cord-333286-lr32e0w4 250 96 adults adult NNS cord-333286-lr32e0w4 250 97 who who WP cord-333286-lr32e0w4 250 98 develop develop VBP cord-333286-lr32e0w4 250 99 common common JJ cord-333286-lr32e0w4 250 100 acute acute JJ cord-333286-lr32e0w4 250 101 respiratory respiratory JJ cord-333286-lr32e0w4 250 102 infectious infectious JJ cord-333286-lr32e0w4 250 103 conditions condition NNS cord-333286-lr32e0w4 250 104 : : : cord-333286-lr32e0w4 250 105 A a DT cord-333286-lr32e0w4 250 106 systematic systematic JJ cord-333286-lr32e0w4 250 107 review review NN cord-333286-lr32e0w4 250 108 and and CC cord-333286-lr32e0w4 250 109 meta meta NNP cord-333286-lr32e0w4 250 110 - - HYPH cord-333286-lr32e0w4 250 111 analysis analysis NN cord-333286-lr32e0w4 251 1 Understanding understand VBG cord-333286-lr32e0w4 251 2 immunomodulatory immunomodulatory JJ cord-333286-lr32e0w4 251 3 effects effect NNS cord-333286-lr32e0w4 251 4 of of IN cord-333286-lr32e0w4 251 5 probiotics probiotic NNS cord-333286-lr32e0w4 251 6 Recovery Recovery NNP cord-333286-lr32e0w4 251 7 of of IN cord-333286-lr32e0w4 251 8 probiotic probiotic JJ cord-333286-lr32e0w4 251 9 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 251 10 rhamnosus rhamnosus NN cord-333286-lr32e0w4 251 11 GG GG NNP cord-333286-lr32e0w4 251 12 in in IN cord-333286-lr32e0w4 251 13 tonsil tonsil JJ cord-333286-lr32e0w4 251 14 tissue tissue NN cord-333286-lr32e0w4 251 15 after after IN cord-333286-lr32e0w4 251 16 oral oral JJ cord-333286-lr32e0w4 251 17 administration administration NN cord-333286-lr32e0w4 251 18 : : : cord-333286-lr32e0w4 251 19 Randomised randomised JJ cord-333286-lr32e0w4 251 20 , , , cord-333286-lr32e0w4 251 21 placebo placebo NN cord-333286-lr32e0w4 251 22 - - HYPH cord-333286-lr32e0w4 251 23 controlled control VBN cord-333286-lr32e0w4 251 24 , , , cord-333286-lr32e0w4 251 25 double double JJ cord-333286-lr32e0w4 251 26 - - HYPH cord-333286-lr32e0w4 251 27 blind blind JJ cord-333286-lr32e0w4 251 28 clinical clinical JJ cord-333286-lr32e0w4 251 29 trial trial NN cord-333286-lr32e0w4 251 30 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 251 31 rhamnosus rhamnosus NN cord-333286-lr32e0w4 251 32 GG GG NNP cord-333286-lr32e0w4 251 33 in in IN cord-333286-lr32e0w4 251 34 adenoid adenoid JJ cord-333286-lr32e0w4 251 35 tissue tissue NN cord-333286-lr32e0w4 251 36 : : : cord-333286-lr32e0w4 251 37 Double double JJ cord-333286-lr32e0w4 251 38 - - HYPH cord-333286-lr32e0w4 251 39 blind blind JJ cord-333286-lr32e0w4 251 40 , , , cord-333286-lr32e0w4 251 41 placebo placebo NN cord-333286-lr32e0w4 251 42 - - HYPH cord-333286-lr32e0w4 251 43 controlled control VBN cord-333286-lr32e0w4 251 44 , , , cord-333286-lr32e0w4 251 45 randomized randomized JJ cord-333286-lr32e0w4 251 46 clinical clinical JJ cord-333286-lr32e0w4 251 47 trial trial NN cord-333286-lr32e0w4 251 48 Identification identification NN cord-333286-lr32e0w4 251 49 of of IN cord-333286-lr32e0w4 251 50 the the DT cord-333286-lr32e0w4 251 51 transcriptional transcriptional JJ cord-333286-lr32e0w4 251 52 response response NN cord-333286-lr32e0w4 251 53 of of IN cord-333286-lr32e0w4 251 54 human human JJ cord-333286-lr32e0w4 251 55 intestinal intestinal JJ cord-333286-lr32e0w4 251 56 mucosa mucosa NN cord-333286-lr32e0w4 251 57 to to IN cord-333286-lr32e0w4 251 58 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 251 59 plantarum plantarum NNS cord-333286-lr32e0w4 251 60 WCFS1 WCFS1 NNS cord-333286-lr32e0w4 251 61 in in IN cord-333286-lr32e0w4 251 62 vivo vivo NNP cord-333286-lr32e0w4 251 63 Regulation regulation NN cord-333286-lr32e0w4 251 64 of of IN cord-333286-lr32e0w4 251 65 intestinal intestinal JJ cord-333286-lr32e0w4 251 66 homeostasis homeostasis NN cord-333286-lr32e0w4 251 67 and and CC cord-333286-lr32e0w4 251 68 immunity immunity NN cord-333286-lr32e0w4 251 69 with with IN cord-333286-lr32e0w4 251 70 probiotic probiotic JJ cord-333286-lr32e0w4 251 71 lactobacilli lactobacilli NN cord-333286-lr32e0w4 251 72 Mucosal Mucosal NNP cord-333286-lr32e0w4 251 73 immunity immunity NN cord-333286-lr32e0w4 251 74 : : : cord-333286-lr32e0w4 251 75 Induction induction NN cord-333286-lr32e0w4 251 76 , , , cord-333286-lr32e0w4 251 77 dissemination dissemination NN cord-333286-lr32e0w4 251 78 , , , cord-333286-lr32e0w4 251 79 and and CC cord-333286-lr32e0w4 251 80 effector effector NN cord-333286-lr32e0w4 251 81 functions function NNS cord-333286-lr32e0w4 251 82 Short Short NNP cord-333286-lr32e0w4 251 83 Chain Chain NNP cord-333286-lr32e0w4 251 84 Fatty fatty JJ cord-333286-lr32e0w4 251 85 Acids acid NNS cord-333286-lr32e0w4 251 86 ( ( -LRB- cord-333286-lr32e0w4 251 87 SCFAs)-Mediated scfas)-mediate VBN cord-333286-lr32e0w4 251 88 Gut Gut NNP cord-333286-lr32e0w4 251 89 Epithelial Epithelial NNP cord-333286-lr32e0w4 251 90 and and CC cord-333286-lr32e0w4 251 91 Immune Immune NNP cord-333286-lr32e0w4 251 92 Regulation Regulation NNP cord-333286-lr32e0w4 251 93 and and CC cord-333286-lr32e0w4 251 94 Its -PRON- PRP$ cord-333286-lr32e0w4 251 95 Relevance relevance NN cord-333286-lr32e0w4 251 96 for for IN cord-333286-lr32e0w4 251 97 Probiotic probiotic JJ cord-333286-lr32e0w4 251 98 mechanisms mechanism NNS cord-333286-lr32e0w4 251 99 of of IN cord-333286-lr32e0w4 251 100 action action NN cord-333286-lr32e0w4 252 1 The the DT cord-333286-lr32e0w4 252 2 Gut Gut NNP cord-333286-lr32e0w4 252 3 - - HYPH cord-333286-lr32e0w4 252 4 Lung Lung NNP cord-333286-lr32e0w4 252 5 Axis Axis NNP cord-333286-lr32e0w4 252 6 in in IN cord-333286-lr32e0w4 252 7 Health Health NNP cord-333286-lr32e0w4 252 8 and and CC cord-333286-lr32e0w4 252 9 Respiratory Respiratory NNP cord-333286-lr32e0w4 252 10 Diseases disease NNS cord-333286-lr32e0w4 252 11 : : : cord-333286-lr32e0w4 253 1 A a DT cord-333286-lr32e0w4 253 2 Place place NN cord-333286-lr32e0w4 253 3 for for IN cord-333286-lr32e0w4 253 4 Inter Inter NNP cord-333286-lr32e0w4 253 5 - - NNP cord-333286-lr32e0w4 253 6 Organ Organ NNP cord-333286-lr32e0w4 253 7 and and CC cord-333286-lr32e0w4 253 8 Inter Inter NNP cord-333286-lr32e0w4 253 9 - - HYPH cord-333286-lr32e0w4 253 10 Kingdom Kingdom NNP cord-333286-lr32e0w4 253 11 Crosstalks Crosstalks NNPS cord-333286-lr32e0w4 253 12 Microbiota Microbiota NNP cord-333286-lr32e0w4 253 13 and and CC cord-333286-lr32e0w4 253 14 Gut Gut NNP cord-333286-lr32e0w4 253 15 - - HYPH cord-333286-lr32e0w4 253 16 Lung lung NN cord-333286-lr32e0w4 253 17 Connection connection NN cord-333286-lr32e0w4 254 1 Lactobacilli Lactobacilli NNP cord-333286-lr32e0w4 254 2 Differentially differentially RB cord-333286-lr32e0w4 254 3 Modulate modulate VBP cord-333286-lr32e0w4 254 4 Expression expression NN cord-333286-lr32e0w4 254 5 of of IN cord-333286-lr32e0w4 254 6 Cytokines Cytokines NNPS cord-333286-lr32e0w4 254 7 and and CC cord-333286-lr32e0w4 254 8 Maturation Maturation NNP cord-333286-lr32e0w4 254 9 Surface Surface NNP cord-333286-lr32e0w4 254 10 Markers Markers NNPS cord-333286-lr32e0w4 254 11 in in IN cord-333286-lr32e0w4 254 12 Murine Murine NNP cord-333286-lr32e0w4 254 13 Dendritic Dendritic NNP cord-333286-lr32e0w4 254 14 Cells Cells NNP cord-333286-lr32e0w4 254 15 Human human JJ cord-333286-lr32e0w4 254 16 antigen antigen NN cord-333286-lr32e0w4 254 17 - - HYPH cord-333286-lr32e0w4 254 18 presenting present VBG cord-333286-lr32e0w4 254 19 cells cell NNS cord-333286-lr32e0w4 254 20 respond respond VBP cord-333286-lr32e0w4 254 21 differently differently RB cord-333286-lr32e0w4 254 22 to to TO cord-333286-lr32e0w4 254 23 gut gut VB cord-333286-lr32e0w4 254 24 - - HYPH cord-333286-lr32e0w4 254 25 derived derive VBN cord-333286-lr32e0w4 254 26 probiotic probiotic JJ cord-333286-lr32e0w4 254 27 bacteria bacteria NNS cord-333286-lr32e0w4 254 28 but but CC cord-333286-lr32e0w4 254 29 mediate mediate VB cord-333286-lr32e0w4 254 30 similar similar JJ cord-333286-lr32e0w4 254 31 strain strain NN cord-333286-lr32e0w4 254 32 - - HYPH cord-333286-lr32e0w4 254 33 dependent dependent JJ cord-333286-lr32e0w4 254 34 NK NK NNP cord-333286-lr32e0w4 254 35 and and CC cord-333286-lr32e0w4 254 36 T T NNP cord-333286-lr32e0w4 254 37 cell cell NN cord-333286-lr32e0w4 254 38 activation activation NN cord-333286-lr32e0w4 254 39 Location location NN cord-333286-lr32e0w4 254 40 , , , cord-333286-lr32e0w4 254 41 location location NN cord-333286-lr32e0w4 254 42 , , , cord-333286-lr32e0w4 254 43 location location NN cord-333286-lr32e0w4 254 44 : : : cord-333286-lr32e0w4 255 1 The the DT cord-333286-lr32e0w4 255 2 impact impact NN cord-333286-lr32e0w4 255 3 of of IN cord-333286-lr32e0w4 255 4 migratory migratory JJ cord-333286-lr32e0w4 255 5 heterogeneity heterogeneity NN cord-333286-lr32e0w4 255 6 on on IN cord-333286-lr32e0w4 255 7 T T NNP cord-333286-lr32e0w4 255 8 cell cell NN cord-333286-lr32e0w4 255 9 function function NN cord-333286-lr32e0w4 255 10 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 255 11 acidophilus acidophilus NN cord-333286-lr32e0w4 255 12 induces induce VBZ cord-333286-lr32e0w4 255 13 virus virus NN cord-333286-lr32e0w4 255 14 immune immune JJ cord-333286-lr32e0w4 255 15 defence defence NN cord-333286-lr32e0w4 255 16 genes gene NNS cord-333286-lr32e0w4 255 17 in in IN cord-333286-lr32e0w4 255 18 murine murine JJ cord-333286-lr32e0w4 255 19 dendritic dendritic JJ cord-333286-lr32e0w4 255 20 cells cell NNS cord-333286-lr32e0w4 255 21 by by IN cord-333286-lr32e0w4 255 22 a a DT cord-333286-lr32e0w4 255 23 Toll toll NN cord-333286-lr32e0w4 255 24 - - HYPH cord-333286-lr32e0w4 255 25 like like JJ cord-333286-lr32e0w4 255 26 receptor-2-dependent receptor-2-dependent NNP cord-333286-lr32e0w4 255 27 mechanism mechanism NN cord-333286-lr32e0w4 255 28 Oral oral JJ cord-333286-lr32e0w4 255 29 administration administration NN cord-333286-lr32e0w4 255 30 of of IN cord-333286-lr32e0w4 255 31 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 255 32 gasseri gasseri NN cord-333286-lr32e0w4 255 33 SBT2055 SBT2055 NNP cord-333286-lr32e0w4 255 34 is be VBZ cord-333286-lr32e0w4 255 35 effective effective JJ cord-333286-lr32e0w4 255 36 for for IN cord-333286-lr32e0w4 255 37 preventing prevent VBG cord-333286-lr32e0w4 255 38 influenza influenza NN cord-333286-lr32e0w4 255 39 in in IN cord-333286-lr32e0w4 255 40 mice mouse NNS cord-333286-lr32e0w4 256 1 Nonpathogenic Nonpathogenic NNP cord-333286-lr32e0w4 256 2 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 256 3 rhamnosus rhamnosus NN cord-333286-lr32e0w4 256 4 activates activate VBZ cord-333286-lr32e0w4 256 5 the the DT cord-333286-lr32e0w4 256 6 inflammasome inflammasome NN cord-333286-lr32e0w4 256 7 and and CC cord-333286-lr32e0w4 256 8 antiviral antiviral JJ cord-333286-lr32e0w4 256 9 responses response NNS cord-333286-lr32e0w4 256 10 in in IN cord-333286-lr32e0w4 256 11 human human JJ cord-333286-lr32e0w4 256 12 macrophages macrophage NNS cord-333286-lr32e0w4 256 13 Inhibition inhibition NN cord-333286-lr32e0w4 256 14 of of IN cord-333286-lr32e0w4 256 15 H9N2 H9N2 NNP cord-333286-lr32e0w4 256 16 virus virus NN cord-333286-lr32e0w4 256 17 invasion invasion NN cord-333286-lr32e0w4 256 18 into into IN cord-333286-lr32e0w4 256 19 dendritic dendritic JJ cord-333286-lr32e0w4 256 20 cells cell NNS cord-333286-lr32e0w4 256 21 by by IN cord-333286-lr32e0w4 256 22 the the DT cord-333286-lr32e0w4 256 23 S S NNP cord-333286-lr32e0w4 256 24 - - HYPH cord-333286-lr32e0w4 256 25 Layer Layer NNP cord-333286-lr32e0w4 256 26 protein protein NN cord-333286-lr32e0w4 256 27 from from IN cord-333286-lr32e0w4 256 28 L. L. NNP cord-333286-lr32e0w4 256 29 acidophilus acidophilus NN cord-333286-lr32e0w4 256 30 ATCC ATCC NNP cord-333286-lr32e0w4 256 31 4356 4356 CD cord-333286-lr32e0w4 257 1 A a DT cord-333286-lr32e0w4 257 2 pathway pathway NN cord-333286-lr32e0w4 257 3 analysis analysis NN cord-333286-lr32e0w4 257 4 of of IN cord-333286-lr32e0w4 257 5 poly(I poly(I NNP cord-333286-lr32e0w4 257 6 : : : cord-333286-lr32e0w4 257 7 C)-induced c)-induced JJ cord-333286-lr32e0w4 257 8 global global JJ cord-333286-lr32e0w4 257 9 gene gene NN cord-333286-lr32e0w4 257 10 expression expression NN cord-333286-lr32e0w4 257 11 change change NN cord-333286-lr32e0w4 257 12 in in IN cord-333286-lr32e0w4 257 13 human human JJ cord-333286-lr32e0w4 257 14 peripheral peripheral JJ cord-333286-lr32e0w4 257 15 blood blood NN cord-333286-lr32e0w4 257 16 mononuclear mononuclear NN cord-333286-lr32e0w4 257 17 cells cell NNS cord-333286-lr32e0w4 258 1 The the DT cord-333286-lr32e0w4 258 2 airway airway NN cord-333286-lr32e0w4 258 3 epithelium epithelium NN cord-333286-lr32e0w4 258 4 : : : cord-333286-lr32e0w4 259 1 Soldier soldier NN cord-333286-lr32e0w4 259 2 in in IN cord-333286-lr32e0w4 259 3 the the DT cord-333286-lr32e0w4 259 4 fight fight NN cord-333286-lr32e0w4 259 5 against against IN cord-333286-lr32e0w4 259 6 respiratory respiratory JJ cord-333286-lr32e0w4 259 7 viruses virus NNS cord-333286-lr32e0w4 260 1 Double double JJ cord-333286-lr32e0w4 260 2 - - HYPH cord-333286-lr32e0w4 260 3 stranded strand VBN cord-333286-lr32e0w4 260 4 RNA RNA NNP cord-333286-lr32e0w4 260 5 induces induce VBZ cord-333286-lr32e0w4 260 6 similar similar JJ cord-333286-lr32e0w4 260 7 pulmonary pulmonary JJ cord-333286-lr32e0w4 260 8 dysfunction dysfunction NN cord-333286-lr32e0w4 260 9 to to IN cord-333286-lr32e0w4 260 10 respiratory respiratory JJ cord-333286-lr32e0w4 260 11 syncytial syncytial JJ cord-333286-lr32e0w4 260 12 virus virus NN cord-333286-lr32e0w4 260 13 in in IN cord-333286-lr32e0w4 260 14 BALB BALB NNP cord-333286-lr32e0w4 260 15 / / SYM cord-333286-lr32e0w4 260 16 c c NN cord-333286-lr32e0w4 260 17 mice mouse NNS cord-333286-lr32e0w4 260 18 Non non JJ cord-333286-lr32e0w4 260 19 - - JJ cord-333286-lr32e0w4 260 20 Viable viable JJ cord-333286-lr32e0w4 260 21 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 260 22 Casei Casei NNP cord-333286-lr32e0w4 261 1 Beneficially beneficially RB cord-333286-lr32e0w4 261 2 Modulates modulate VBZ cord-333286-lr32e0w4 261 3 Poly Poly NNP cord-333286-lr32e0w4 261 4 I i NN cord-333286-lr32e0w4 261 5 : : : cord-333286-lr32e0w4 262 1 C C NNP cord-333286-lr32e0w4 262 2 Immune Immune NNP cord-333286-lr32e0w4 262 3 Response response NN cord-333286-lr32e0w4 262 4 in in IN cord-333286-lr32e0w4 262 5 Co Co NNP cord-333286-lr32e0w4 262 6 - - NNS cord-333286-lr32e0w4 262 7 Cultures culture NNS cord-333286-lr32e0w4 262 8 of of IN cord-333286-lr32e0w4 262 9 Human Human NNP cord-333286-lr32e0w4 262 10 Cells cell NNS cord-333286-lr32e0w4 262 11 Immunobiotic immunobiotic JJ cord-333286-lr32e0w4 262 12 strains strain NNS cord-333286-lr32e0w4 262 13 modulate modulate VBP cord-333286-lr32e0w4 262 14 Toll toll NN cord-333286-lr32e0w4 262 15 - - HYPH cord-333286-lr32e0w4 262 16 like like JJ cord-333286-lr32e0w4 262 17 receptor receptor NN cord-333286-lr32e0w4 263 1 3 3 CD cord-333286-lr32e0w4 263 2 agonist agonist NN cord-333286-lr32e0w4 263 3 induced induce VBN cord-333286-lr32e0w4 263 4 innate innate JJ cord-333286-lr32e0w4 263 5 antiviral antiviral JJ cord-333286-lr32e0w4 263 6 immune immune JJ cord-333286-lr32e0w4 263 7 response response NN cord-333286-lr32e0w4 263 8 in in IN cord-333286-lr32e0w4 263 9 human human JJ cord-333286-lr32e0w4 263 10 intestinal intestinal JJ cord-333286-lr32e0w4 263 11 epithelial epithelial JJ cord-333286-lr32e0w4 263 12 cells cell NNS cord-333286-lr32e0w4 263 13 by by IN cord-333286-lr32e0w4 263 14 modulating modulate VBG cord-333286-lr32e0w4 263 15 IFN IFN NNP cord-333286-lr32e0w4 263 16 regulatory regulatory JJ cord-333286-lr32e0w4 263 17 factor factor NN cord-333286-lr32e0w4 263 18 3 3 CD cord-333286-lr32e0w4 263 19 and and CC cord-333286-lr32e0w4 264 1 NF NF NNP cord-333286-lr32e0w4 264 2 - - HYPH cord-333286-lr32e0w4 264 3 κB κB NNP cord-333286-lr32e0w4 264 4 signaling signal VBG cord-333286-lr32e0w4 264 5 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 264 6 casei casei NN cord-333286-lr32e0w4 264 7 Zhang Zhang NNP cord-333286-lr32e0w4 264 8 modulate modulate VBP cord-333286-lr32e0w4 264 9 cytokine cytokine NN cord-333286-lr32e0w4 264 10 and and CC cord-333286-lr32e0w4 264 11 Toll toll NN cord-333286-lr32e0w4 264 12 - - HYPH cord-333286-lr32e0w4 264 13 like like JJ cord-333286-lr32e0w4 264 14 receptor receptor NN cord-333286-lr32e0w4 264 15 expression expression NN cord-333286-lr32e0w4 264 16 and and CC cord-333286-lr32e0w4 264 17 beneficially beneficially RB cord-333286-lr32e0w4 264 18 regulate regulate VB cord-333286-lr32e0w4 264 19 poly poly NN cord-333286-lr32e0w4 264 20 I i NN cord-333286-lr32e0w4 264 21 : : : cord-333286-lr32e0w4 264 22 C c NN cord-333286-lr32e0w4 264 23 - - HYPH cord-333286-lr32e0w4 264 24 induced induce VBN cord-333286-lr32e0w4 264 25 immune immune JJ cord-333286-lr32e0w4 264 26 responses response NNS cord-333286-lr32e0w4 264 27 in in IN cord-333286-lr32e0w4 264 28 RAW264 RAW264 NNP cord-333286-lr32e0w4 264 29 . . . cord-333286-lr32e0w4 265 1 7 7 CD cord-333286-lr32e0w4 265 2 macrophages macrophage NNS cord-333286-lr32e0w4 266 1 Immunobiotic immunobiotic JJ cord-333286-lr32e0w4 266 2 lactic lactic JJ cord-333286-lr32e0w4 266 3 acid acid NN cord-333286-lr32e0w4 266 4 bacteria bacteria NNS cord-333286-lr32e0w4 266 5 beneficially beneficially RB cord-333286-lr32e0w4 266 6 regulate regulate VBP cord-333286-lr32e0w4 266 7 immune immune JJ cord-333286-lr32e0w4 266 8 response response NN cord-333286-lr32e0w4 266 9 triggered trigger VBN cord-333286-lr32e0w4 266 10 by by IN cord-333286-lr32e0w4 266 11 poly poly NNP cord-333286-lr32e0w4 266 12 ( ( -LRB- cord-333286-lr32e0w4 266 13 I i NN cord-333286-lr32e0w4 266 14 : : : cord-333286-lr32e0w4 266 15 C C NNP cord-333286-lr32e0w4 266 16 ) ) -RRB- cord-333286-lr32e0w4 266 17 in in IN cord-333286-lr32e0w4 266 18 porcine porcine JJ cord-333286-lr32e0w4 266 19 intestinal intestinal JJ cord-333286-lr32e0w4 266 20 epithelial epithelial JJ cord-333286-lr32e0w4 266 21 cells cell NNS cord-333286-lr32e0w4 267 1 Immunobiotic Immunobiotic NNP cord-333286-lr32e0w4 267 2 Bifidobacteria Bifidobacteria NNP cord-333286-lr32e0w4 267 3 Strains Strains NNPS cord-333286-lr32e0w4 267 4 Modulate modulate VBP cord-333286-lr32e0w4 267 5 Rotavirus rotavirus NN cord-333286-lr32e0w4 267 6 Immune Immune NNP cord-333286-lr32e0w4 267 7 Response response NN cord-333286-lr32e0w4 267 8 in in IN cord-333286-lr32e0w4 267 9 Porcine Porcine NNP cord-333286-lr32e0w4 267 10 Intestinal Intestinal NNP cord-333286-lr32e0w4 267 11 Epitheliocytes Epitheliocytes NNPS cord-333286-lr32e0w4 267 12 via via IN cord-333286-lr32e0w4 267 13 Pattern Pattern NNP cord-333286-lr32e0w4 267 14 Recognition Recognition NNP cord-333286-lr32e0w4 267 15 Receptor Receptor NNP cord-333286-lr32e0w4 267 16 Signaling Signaling NNP cord-333286-lr32e0w4 267 17 Exopolysaccharides Exopolysaccharides NNP cord-333286-lr32e0w4 267 18 from from IN cord-333286-lr32e0w4 267 19 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 267 20 delbrueckii delbrueckii NNP cord-333286-lr32e0w4 267 21 OLL1073R-1 OLL1073R-1 NNP cord-333286-lr32e0w4 267 22 modulate modulate VBP cord-333286-lr32e0w4 267 23 innate innate JJ cord-333286-lr32e0w4 267 24 antiviral antiviral JJ cord-333286-lr32e0w4 267 25 immune immune JJ cord-333286-lr32e0w4 267 26 response response NN cord-333286-lr32e0w4 267 27 in in IN cord-333286-lr32e0w4 267 28 porcine porcine JJ cord-333286-lr32e0w4 267 29 intestinal intestinal JJ cord-333286-lr32e0w4 267 30 epithelial epithelial JJ cord-333286-lr32e0w4 267 31 cells cell NNS cord-333286-lr32e0w4 267 32 Immunobiotic Immunobiotic NNP cord-333286-lr32e0w4 267 33 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 267 34 rhamnosus rhamnosus NN cord-333286-lr32e0w4 267 35 strains strain NNS cord-333286-lr32e0w4 267 36 differentially differentially RB cord-333286-lr32e0w4 267 37 modulate modulate VBP cord-333286-lr32e0w4 267 38 antiviral antiviral JJ cord-333286-lr32e0w4 267 39 immune immune JJ cord-333286-lr32e0w4 267 40 response response NN cord-333286-lr32e0w4 267 41 in in IN cord-333286-lr32e0w4 267 42 porcine porcine JJ cord-333286-lr32e0w4 267 43 intestinal intestinal JJ cord-333286-lr32e0w4 267 44 epithelial epithelial NN cord-333286-lr32e0w4 267 45 and and CC cord-333286-lr32e0w4 267 46 antigen antigen NN cord-333286-lr32e0w4 267 47 presenting present VBG cord-333286-lr32e0w4 267 48 cells cell NNS cord-333286-lr32e0w4 267 49 Orally orally RB cord-333286-lr32e0w4 267 50 administered administer VBD cord-333286-lr32e0w4 267 51 heat heat NN cord-333286-lr32e0w4 267 52 - - HYPH cord-333286-lr32e0w4 267 53 killed kill VBN cord-333286-lr32e0w4 267 54 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 267 55 paracasei paracasei NN cord-333286-lr32e0w4 268 1 MCC1849 MCC1849 NNP cord-333286-lr32e0w4 268 2 enhances enhance VBZ cord-333286-lr32e0w4 268 3 antigen antigen NN cord-333286-lr32e0w4 268 4 - - HYPH cord-333286-lr32e0w4 268 5 specific specific JJ cord-333286-lr32e0w4 268 6 IgA IgA NNP cord-333286-lr32e0w4 268 7 secretion secretion NN cord-333286-lr32e0w4 268 8 and and CC cord-333286-lr32e0w4 268 9 induces induce VBZ cord-333286-lr32e0w4 268 10 follicular follicular JJ cord-333286-lr32e0w4 268 11 helper helper NN cord-333286-lr32e0w4 268 12 T t NN cord-333286-lr32e0w4 268 13 cells cell NNS cord-333286-lr32e0w4 268 14 in in IN cord-333286-lr32e0w4 268 15 mice mouse NNS cord-333286-lr32e0w4 269 1 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 269 2 paracasei paracasei NN cord-333286-lr32e0w4 269 3 feeding feeding NN cord-333286-lr32e0w4 269 4 improves improve VBZ cord-333286-lr32e0w4 269 5 immune immune JJ cord-333286-lr32e0w4 269 6 control control NN cord-333286-lr32e0w4 269 7 of of IN cord-333286-lr32e0w4 269 8 influenza influenza NN cord-333286-lr32e0w4 269 9 infection infection NN cord-333286-lr32e0w4 269 10 in in IN cord-333286-lr32e0w4 269 11 mice mouse NNS cord-333286-lr32e0w4 270 1 Consecutive consecutive JJ cord-333286-lr32e0w4 270 2 oral oral JJ cord-333286-lr32e0w4 270 3 administration administration NN cord-333286-lr32e0w4 270 4 of of IN cord-333286-lr32e0w4 270 5 Bifidobacterium Bifidobacterium NNP cord-333286-lr32e0w4 270 6 longum longum NNP cord-333286-lr32e0w4 271 1 MM-2 MM-2 NNP cord-333286-lr32e0w4 271 2 improves improve VBZ cord-333286-lr32e0w4 271 3 the the DT cord-333286-lr32e0w4 271 4 defense defense NN cord-333286-lr32e0w4 271 5 system system NN cord-333286-lr32e0w4 271 6 against against IN cord-333286-lr32e0w4 271 7 influenza influenza NN cord-333286-lr32e0w4 271 8 virus virus NN cord-333286-lr32e0w4 271 9 infection infection NN cord-333286-lr32e0w4 271 10 by by IN cord-333286-lr32e0w4 271 11 enhancing enhance VBG cord-333286-lr32e0w4 271 12 natural natural JJ cord-333286-lr32e0w4 271 13 killer killer NN cord-333286-lr32e0w4 271 14 cell cell NN cord-333286-lr32e0w4 271 15 activity activity NN cord-333286-lr32e0w4 271 16 in in IN cord-333286-lr32e0w4 271 17 a a DT cord-333286-lr32e0w4 271 18 murine murine JJ cord-333286-lr32e0w4 271 19 model model NN cord-333286-lr32e0w4 271 20 Immunomodulatory Immunomodulatory NNP cord-333286-lr32e0w4 271 21 and and CC cord-333286-lr32e0w4 271 22 prophylactic prophylactic JJ cord-333286-lr32e0w4 271 23 effects effect NNS cord-333286-lr32e0w4 271 24 of of IN cord-333286-lr32e0w4 271 25 Bifidobacterium bifidobacterium NN cord-333286-lr32e0w4 271 26 bifidum bifidum NN cord-333286-lr32e0w4 271 27 probiotic probiotic JJ cord-333286-lr32e0w4 271 28 strain strain NN cord-333286-lr32e0w4 271 29 on on IN cord-333286-lr32e0w4 271 30 influenza influenza NN cord-333286-lr32e0w4 271 31 infection infection NN cord-333286-lr32e0w4 271 32 in in IN cord-333286-lr32e0w4 271 33 mice mouse NNS cord-333286-lr32e0w4 272 1 Oral oral JJ cord-333286-lr32e0w4 272 2 intake intake NN cord-333286-lr32e0w4 272 3 of of IN cord-333286-lr32e0w4 272 4 Lactobacillus Lactobacillus NNP cord-333286-lr32e0w4 272 5 rhamnosus rhamnosus NN cord-333286-lr32e0w4 272 6 M21 M21 NNP cord-333286-lr32e0w4 272 7 enhances enhance VBZ cord-333286-lr32e0w4 272 8 the the DT cord-333286-lr32e0w4 272 9 survival survival NN cord-333286-lr32e0w4 272 10 rate rate NN cord-333286-lr32e0w4 272 11 of of IN cord-333286-lr32e0w4 272 12 mice mouse NNS cord-333286-lr32e0w4 272 13 lethally lethally RB cord-333286-lr32e0w4 272 14 infected infect VBN cord-333286-lr32e0w4 272 15 with with IN cord-333286-lr32e0w4 272 16 influenza influenza NN cord-333286-lr32e0w4 272 17 virus virus NN cord-333286-lr32e0w4 272 18 Prevention prevention NN cord-333286-lr32e0w4 272 19 of of IN cord-333286-lr32e0w4 272 20 respiratory respiratory JJ cord-333286-lr32e0w4 272 21 syncytial syncytial JJ cord-333286-lr32e0w4 272 22 virus virus NN cord-333286-lr32e0w4 272 23 infection infection NN cord-333286-lr32e0w4 272 24 with with IN cord-333286-lr32e0w4 272 25 probiotic probiotic JJ cord-333286-lr32e0w4 272 26 lactic lactic JJ cord-333286-lr32e0w4 272 27 acid acid NN cord-333286-lr32e0w4 272 28 bacterium bacterium NN cord-333286-lr32e0w4 272 29 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 272 30 gasseri gasseri NN cord-333286-lr32e0w4 272 31 SBT2055 SBT2055 VBG cord-333286-lr32e0w4 272 32 Probiotics probiotic NNS cord-333286-lr32e0w4 272 33 for for IN cord-333286-lr32e0w4 272 34 respiratory respiratory JJ cord-333286-lr32e0w4 272 35 tract tract NN cord-333286-lr32e0w4 272 36 infections infection NNS cord-333286-lr32e0w4 272 37 in in IN cord-333286-lr32e0w4 272 38 children child NNS cord-333286-lr32e0w4 272 39 attending attend VBG cord-333286-lr32e0w4 272 40 day day NN cord-333286-lr32e0w4 272 41 care care NN cord-333286-lr32e0w4 272 42 centers center NNS cord-333286-lr32e0w4 272 43 - - : cord-333286-lr32e0w4 272 44 a a DT cord-333286-lr32e0w4 272 45 systematic systematic JJ cord-333286-lr32e0w4 272 46 review review NN cord-333286-lr32e0w4 272 47 Probiotics probiotic NNS cord-333286-lr32e0w4 272 48 for for IN cord-333286-lr32e0w4 272 49 prevention prevention NN cord-333286-lr32e0w4 272 50 and and CC cord-333286-lr32e0w4 272 51 treatment treatment NN cord-333286-lr32e0w4 272 52 of of IN cord-333286-lr32e0w4 272 53 respiratory respiratory JJ cord-333286-lr32e0w4 272 54 tract tract NN cord-333286-lr32e0w4 272 55 infections infection NNS cord-333286-lr32e0w4 272 56 in in IN cord-333286-lr32e0w4 272 57 children child NNS cord-333286-lr32e0w4 272 58 : : : cord-333286-lr32e0w4 272 59 A a DT cord-333286-lr32e0w4 272 60 systematic systematic JJ cord-333286-lr32e0w4 272 61 review review NN cord-333286-lr32e0w4 272 62 and and CC cord-333286-lr32e0w4 272 63 meta meta NNP cord-333286-lr32e0w4 272 64 - - HYPH cord-333286-lr32e0w4 272 65 analysis analysis NN cord-333286-lr32e0w4 272 66 of of IN cord-333286-lr32e0w4 272 67 randomized randomized JJ cord-333286-lr32e0w4 272 68 controlled control VBN cord-333286-lr32e0w4 272 69 trials trial NNS cord-333286-lr32e0w4 273 1 Prebiotic prebiotic JJ cord-333286-lr32e0w4 273 2 and and CC cord-333286-lr32e0w4 273 3 probiotic probiotic JJ cord-333286-lr32e0w4 273 4 supplementation supplementation NN cord-333286-lr32e0w4 273 5 prevents prevent VBZ cord-333286-lr32e0w4 273 6 rhinovirus rhinovirus NN cord-333286-lr32e0w4 273 7 infections infection NNS cord-333286-lr32e0w4 273 8 in in IN cord-333286-lr32e0w4 273 9 preterm preterm JJ cord-333286-lr32e0w4 273 10 infants infant NNS cord-333286-lr32e0w4 273 11 : : : cord-333286-lr32e0w4 274 1 A a DT cord-333286-lr32e0w4 274 2 randomized randomized JJ cord-333286-lr32e0w4 274 3 , , , cord-333286-lr32e0w4 274 4 placebo placebo NN cord-333286-lr32e0w4 274 5 - - HYPH cord-333286-lr32e0w4 274 6 controlled control VBN cord-333286-lr32e0w4 274 7 trial trial NN cord-333286-lr32e0w4 274 8 Effects effect NNS cord-333286-lr32e0w4 274 9 of of IN cord-333286-lr32e0w4 274 10 probiotic probiotic JJ cord-333286-lr32e0w4 274 11 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 274 12 brevis brevis NN cord-333286-lr32e0w4 274 13 KB290 KB290 NNP cord-333286-lr32e0w4 274 14 on on IN cord-333286-lr32e0w4 274 15 incidence incidence NN cord-333286-lr32e0w4 274 16 of of IN cord-333286-lr32e0w4 274 17 influenza influenza NN cord-333286-lr32e0w4 274 18 infection infection NN cord-333286-lr32e0w4 274 19 among among IN cord-333286-lr32e0w4 274 20 schoolchildren schoolchildren NNS cord-333286-lr32e0w4 274 21 : : : cord-333286-lr32e0w4 274 22 An an DT cord-333286-lr32e0w4 274 23 open open JJ cord-333286-lr32e0w4 274 24 - - HYPH cord-333286-lr32e0w4 274 25 label label NN cord-333286-lr32e0w4 274 26 pilot pilot NN cord-333286-lr32e0w4 274 27 study study NN cord-333286-lr32e0w4 275 1 The the DT cord-333286-lr32e0w4 275 2 use use NN cord-333286-lr32e0w4 275 3 of of IN cord-333286-lr32e0w4 275 4 the the DT cord-333286-lr32e0w4 275 5 probiotic probiotic JJ cord-333286-lr32e0w4 275 6 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 275 7 rhamnosus rhamnosus NN cord-333286-lr32e0w4 275 8 GG GG NNP cord-333286-lr32e0w4 275 9 and and CC cord-333286-lr32e0w4 275 10 viral viral JJ cord-333286-lr32e0w4 275 11 findings finding NNS cord-333286-lr32e0w4 275 12 in in IN cord-333286-lr32e0w4 275 13 the the DT cord-333286-lr32e0w4 275 14 nasopharynx nasopharynx NN cord-333286-lr32e0w4 275 15 of of IN cord-333286-lr32e0w4 275 16 children child NNS cord-333286-lr32e0w4 275 17 attending attend VBG cord-333286-lr32e0w4 275 18 day day NN cord-333286-lr32e0w4 275 19 care care NN cord-333286-lr32e0w4 275 20 Human Human NNP cord-333286-lr32e0w4 275 21 bocavirus bocavirus NN cord-333286-lr32e0w4 275 22 in in IN cord-333286-lr32e0w4 275 23 the the DT cord-333286-lr32e0w4 275 24 nasopharynx nasopharynx NN cord-333286-lr32e0w4 275 25 of of IN cord-333286-lr32e0w4 275 26 otitis otitis NN cord-333286-lr32e0w4 275 27 - - HYPH cord-333286-lr32e0w4 275 28 prone prone JJ cord-333286-lr32e0w4 275 29 children child NNS cord-333286-lr32e0w4 275 30 Specific specific JJ cord-333286-lr32e0w4 275 31 probiotics probiotic NNS cord-333286-lr32e0w4 275 32 and and CC cord-333286-lr32e0w4 275 33 virological virological JJ cord-333286-lr32e0w4 275 34 findings finding NNS cord-333286-lr32e0w4 275 35 in in IN cord-333286-lr32e0w4 275 36 symptomatic symptomatic JJ cord-333286-lr32e0w4 275 37 conscripts conscript NNS cord-333286-lr32e0w4 275 38 attending attend VBG cord-333286-lr32e0w4 275 39 military military JJ cord-333286-lr32e0w4 275 40 service service NN cord-333286-lr32e0w4 275 41 in in IN cord-333286-lr32e0w4 275 42 Finland Finland NNP cord-333286-lr32e0w4 275 43 Probiotics Probiotics NNPS cord-333286-lr32e0w4 275 44 to to TO cord-333286-lr32e0w4 275 45 Prevent prevent VB cord-333286-lr32e0w4 275 46 Respiratory respiratory JJ cord-333286-lr32e0w4 275 47 Infections infection NNS cord-333286-lr32e0w4 275 48 in in IN cord-333286-lr32e0w4 275 49 Nursing Nursing NNP cord-333286-lr32e0w4 275 50 Homes home NNS cord-333286-lr32e0w4 275 51 : : : cord-333286-lr32e0w4 275 52 A a DT cord-333286-lr32e0w4 275 53 Pilot Pilot NNP cord-333286-lr32e0w4 275 54 Randomized Randomized NNP cord-333286-lr32e0w4 275 55 Controlled Controlled NNP cord-333286-lr32e0w4 275 56 Trial Trial NNP cord-333286-lr32e0w4 275 57 Effect Effect NNP cord-333286-lr32e0w4 275 58 of of IN cord-333286-lr32e0w4 275 59 live live JJ cord-333286-lr32e0w4 275 60 and and CC cord-333286-lr32e0w4 275 61 inactivated inactivate VBD cord-333286-lr32e0w4 275 62 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 275 63 rhamnosus rhamnosus NN cord-333286-lr32e0w4 275 64 GG GG NNP cord-333286-lr32e0w4 275 65 on on IN cord-333286-lr32e0w4 275 66 experimentally experimentally RB cord-333286-lr32e0w4 275 67 induced induce VBN cord-333286-lr32e0w4 275 68 rhinovirus rhinovirus NN cord-333286-lr32e0w4 275 69 colds cold NNS cord-333286-lr32e0w4 275 70 : : : cord-333286-lr32e0w4 275 71 Randomised randomised JJ cord-333286-lr32e0w4 275 72 , , , cord-333286-lr32e0w4 275 73 double double JJ cord-333286-lr32e0w4 275 74 blind blind JJ cord-333286-lr32e0w4 275 75 , , , cord-333286-lr32e0w4 275 76 placebo placebo NN cord-333286-lr32e0w4 275 77 - - HYPH cord-333286-lr32e0w4 275 78 controlled control VBN cord-333286-lr32e0w4 275 79 pilot pilot NN cord-333286-lr32e0w4 275 80 trial trial NN cord-333286-lr32e0w4 275 81 Human human JJ cord-333286-lr32e0w4 275 82 rhinovirus rhinovirus NN cord-333286-lr32e0w4 275 83 in in IN cord-333286-lr32e0w4 275 84 experimental experimental JJ cord-333286-lr32e0w4 275 85 infection infection NN cord-333286-lr32e0w4 275 86 after after IN cord-333286-lr32e0w4 275 87 peroral peroral JJ cord-333286-lr32e0w4 275 88 Lactobacillus lactobacillus NN cord-333286-lr32e0w4 275 89 rhamnosus rhamnosus NN cord-333286-lr32e0w4 275 90 GG GG NNP cord-333286-lr32e0w4 275 91 consumption consumption NN cord-333286-lr32e0w4 275 92 , , , cord-333286-lr32e0w4 275 93 a a DT cord-333286-lr32e0w4 275 94 pilot pilot NN cord-333286-lr32e0w4 275 95 study study NN cord-333286-lr32e0w4 275 96 Effect effect NN cord-333286-lr32e0w4 275 97 of of IN cord-333286-lr32e0w4 275 98 probiotic probiotic NN cord-333286-lr32e0w4 275 99 on on IN cord-333286-lr32e0w4 275 100 innate innate JJ cord-333286-lr32e0w4 275 101 inflammatory inflammatory JJ cord-333286-lr32e0w4 275 102 response response NN cord-333286-lr32e0w4 275 103 and and CC cord-333286-lr32e0w4 275 104 viral viral JJ cord-333286-lr32e0w4 275 105 shedding shedding NN cord-333286-lr32e0w4 275 106 in in IN cord-333286-lr32e0w4 275 107 experimental experimental JJ cord-333286-lr32e0w4 275 108 rhinovirus rhinovirus NN cord-333286-lr32e0w4 275 109 infection infection NN cord-333286-lr32e0w4 275 110 - - : cord-333286-lr32e0w4 275 111 A A NNP cord-333286-lr32e0w4 275 112 randomized randomized JJ cord-333286-lr32e0w4 275 113 controlled control VBN cord-333286-lr32e0w4 275 114 trial trial NN cord-333286-lr32e0w4 275 115 Probiotic probiotic JJ cord-333286-lr32e0w4 275 116 supplementation supplementation NN cord-333286-lr32e0w4 275 117 for for IN cord-333286-lr32e0w4 275 118 respiratory respiratory JJ cord-333286-lr32e0w4 275 119 and and CC cord-333286-lr32e0w4 275 120 gastrointestinal gastrointestinal JJ cord-333286-lr32e0w4 275 121 illness illness NN cord-333286-lr32e0w4 275 122 symptoms symptom NNS cord-333286-lr32e0w4 275 123 in in IN cord-333286-lr32e0w4 275 124 healthy healthy JJ cord-333286-lr32e0w4 275 125 physically physically RB cord-333286-lr32e0w4 275 126 active active JJ cord-333286-lr32e0w4 275 127 individuals individual NNS