id sid tid token lemma pos cord-336256-d5292aga 1 1 key key NN cord-336256-d5292aga 1 2 : : : cord-336256-d5292aga 1 3 cord-336256-d5292aga cord-336256-d5292aga NNP cord-336256-d5292aga 1 4 authors author NNS cord-336256-d5292aga 1 5 : : : cord-336256-d5292aga 1 6 Méplan Méplan NNP cord-336256-d5292aga 1 7 , , , cord-336256-d5292aga 1 8 Catherine Catherine NNP cord-336256-d5292aga 1 9 ; ; : cord-336256-d5292aga 1 10 Hughes Hughes NNP cord-336256-d5292aga 1 11 , , , cord-336256-d5292aga 1 12 David David NNP cord-336256-d5292aga 1 13 J. J. NNP cord-336256-d5292aga 2 1 title title NN cord-336256-d5292aga 2 2 : : : cord-336256-d5292aga 3 1 The the DT cord-336256-d5292aga 3 2 Role role NN cord-336256-d5292aga 3 3 of of IN cord-336256-d5292aga 3 4 Selenium Selenium NNP cord-336256-d5292aga 3 5 in in IN cord-336256-d5292aga 3 6 Health Health NNP cord-336256-d5292aga 3 7 and and CC cord-336256-d5292aga 3 8 Disease Disease NNP cord-336256-d5292aga 3 9 : : : cord-336256-d5292aga 3 10 Emerging Emerging NNP cord-336256-d5292aga 3 11 and and CC cord-336256-d5292aga 3 12 Recurring Recurring NNP cord-336256-d5292aga 3 13 Trends Trends NNPS cord-336256-d5292aga 3 14 date date NN cord-336256-d5292aga 3 15 : : : cord-336256-d5292aga 3 16 2020 2020 CD cord-336256-d5292aga 3 17 - - HYPH cord-336256-d5292aga 3 18 04 04 CD cord-336256-d5292aga 3 19 - - SYM cord-336256-d5292aga 3 20 10 10 CD cord-336256-d5292aga 3 21 journal journal NN cord-336256-d5292aga 3 22 : : : cord-336256-d5292aga 4 1 Nutrients nutrient NNS cord-336256-d5292aga 4 2 DOI DOI NNP cord-336256-d5292aga 4 3 : : : cord-336256-d5292aga 4 4 10.3390/ 10.3390/ CD cord-336256-d5292aga 5 1 nu12041049 nu12041049 NNP cord-336256-d5292aga 5 2 sha sha NNP cord-336256-d5292aga 5 3 : : : cord-336256-d5292aga 5 4 829e672a64411439cf1e7a0388290b8a738bae3a 829e672a64411439cf1e7a0388290b8a738bae3a NNP cord-336256-d5292aga 5 5 doc_id doc_id CD cord-336256-d5292aga 5 6 : : : cord-336256-d5292aga 5 7 336256 336256 CD cord-336256-d5292aga 5 8 cord_uid cord_uid NNS cord-336256-d5292aga 5 9 : : : cord-336256-d5292aga 5 10 d5292aga d5292aga RB cord-336256-d5292aga 6 1 In in IN cord-336256-d5292aga 6 2 this this DT cord-336256-d5292aga 6 3 Special Special NNP cord-336256-d5292aga 6 4 Issue issue NN cord-336256-d5292aga 6 5 of of IN cord-336256-d5292aga 6 6 Nutrients nutrient NNS cord-336256-d5292aga 6 7 , , , cord-336256-d5292aga 6 8 " " `` cord-336256-d5292aga 6 9 The the DT cord-336256-d5292aga 6 10 Role Role NNP cord-336256-d5292aga 6 11 of of IN cord-336256-d5292aga 6 12 Selenium Selenium NNP cord-336256-d5292aga 6 13 in in IN cord-336256-d5292aga 6 14 Health Health NNP cord-336256-d5292aga 6 15 and and CC cord-336256-d5292aga 6 16 Disease Disease NNP cord-336256-d5292aga 6 17 " " '' cord-336256-d5292aga 6 18 covers cover VBZ cord-336256-d5292aga 6 19 diverse diverse JJ cord-336256-d5292aga 6 20 diseases disease NNS cord-336256-d5292aga 6 21 in in IN cord-336256-d5292aga 6 22 the the DT cord-336256-d5292aga 6 23 8 8 CD cord-336256-d5292aga 6 24 original original JJ cord-336256-d5292aga 6 25 research research NN cord-336256-d5292aga 6 26 articles article NNS cord-336256-d5292aga 6 27 and and CC cord-336256-d5292aga 6 28 2 2 CD cord-336256-d5292aga 6 29 reviews review NNS cord-336256-d5292aga 6 30 , , , cord-336256-d5292aga 6 31 such such JJ cord-336256-d5292aga 6 32 as as IN cord-336256-d5292aga 6 33 cardiovascular cardiovascular JJ cord-336256-d5292aga 6 34 disorders disorder NNS cord-336256-d5292aga 6 35 ( ( -LRB- cord-336256-d5292aga 6 36 CVD CVD NNP cord-336256-d5292aga 6 37 ) ) -RRB- cord-336256-d5292aga 6 38 , , , cord-336256-d5292aga 6 39 metabolic metabolic JJ cord-336256-d5292aga 6 40 syndrome syndrome NN cord-336256-d5292aga 6 41 , , , cord-336256-d5292aga 6 42 obesity obesity NN cord-336256-d5292aga 6 43 , , , cord-336256-d5292aga 6 44 cancer cancer NN cord-336256-d5292aga 6 45 , , , cord-336256-d5292aga 6 46 and and CC cord-336256-d5292aga 6 47 viral viral JJ cord-336256-d5292aga 6 48 infection infection NN cord-336256-d5292aga 6 49 , , , cord-336256-d5292aga 6 50 and and CC cord-336256-d5292aga 6 51 highlights highlight VBZ cord-336256-d5292aga 6 52 novel novel JJ cord-336256-d5292aga 6 53 potential potential JJ cord-336256-d5292aga 6 54 biomarkers biomarker NNS cord-336256-d5292aga 6 55 of of IN cord-336256-d5292aga 6 56 disease disease NN cord-336256-d5292aga 6 57 risk risk NN cord-336256-d5292aga 6 58 and and CC cord-336256-d5292aga 6 59 prognosis prognosis NN cord-336256-d5292aga 6 60 [ [ -LRB- cord-336256-d5292aga 6 61 ... ... NFP cord-336256-d5292aga 6 62 ] ] -RRB- cord-336256-d5292aga 6 63 . . . cord-336256-d5292aga 7 1 Although although IN cord-336256-d5292aga 7 2 links link NNS cord-336256-d5292aga 7 3 between between IN cord-336256-d5292aga 7 4 Se Se NNP cord-336256-d5292aga 7 5 levels level NNS cord-336256-d5292aga 7 6 , , , cord-336256-d5292aga 7 7 selenoprotein selenoprotein JJ cord-336256-d5292aga 7 8 expression expression NN cord-336256-d5292aga 7 9 , , , cord-336256-d5292aga 7 10 and and CC cord-336256-d5292aga 7 11 CVD CVD NNP cord-336256-d5292aga 7 12 or or CC cord-336256-d5292aga 7 13 lipid lipid NN cord-336256-d5292aga 7 14 metabolism metabolism NN cord-336256-d5292aga 7 15 are be VBP cord-336256-d5292aga 7 16 well well RB cord-336256-d5292aga 7 17 established establish VBN cord-336256-d5292aga 7 18 [ [ -LRB- cord-336256-d5292aga 7 19 1 1 CD cord-336256-d5292aga 7 20 , , , cord-336256-d5292aga 7 21 2 2 CD cord-336256-d5292aga 7 22 ] ] -RRB- cord-336256-d5292aga 7 23 , , , cord-336256-d5292aga 7 24 the the DT cord-336256-d5292aga 7 25 mechanisms mechanism NNS cord-336256-d5292aga 7 26 supporting support VBG cord-336256-d5292aga 7 27 these these DT cord-336256-d5292aga 7 28 associations association NNS cord-336256-d5292aga 7 29 remain remain VBP cord-336256-d5292aga 7 30 unclear unclear JJ cord-336256-d5292aga 7 31 . . . cord-336256-d5292aga 8 1 Two two CD cord-336256-d5292aga 8 2 of of IN cord-336256-d5292aga 8 3 the the DT cord-336256-d5292aga 8 4 manuscripts manuscript NNS cord-336256-d5292aga 8 5 presented present VBN cord-336256-d5292aga 8 6 in in IN cord-336256-d5292aga 8 7 this this DT cord-336256-d5292aga 8 8 Issue issue NN cord-336256-d5292aga 8 9 established establish VBN cord-336256-d5292aga 8 10 , , , cord-336256-d5292aga 8 11 in in IN cord-336256-d5292aga 8 12 distinct distinct JJ cord-336256-d5292aga 8 13 Northern northern JJ cord-336256-d5292aga 8 14 European european JJ cord-336256-d5292aga 8 15 populations population NNS cord-336256-d5292aga 8 16 , , , cord-336256-d5292aga 8 17 two two CD cord-336256-d5292aga 8 18 novel novel NN cord-336256-d5292aga 8 19 Se Se NNP cord-336256-d5292aga 8 20 - - HYPH cord-336256-d5292aga 8 21 related relate VBN cord-336256-d5292aga 8 22 biomarkers biomarker NNS cord-336256-d5292aga 8 23 of of IN cord-336256-d5292aga 8 24 risk risk NN cord-336256-d5292aga 8 25 and and CC cord-336256-d5292aga 8 26 prognosis prognosis NN cord-336256-d5292aga 8 27 for for IN cord-336256-d5292aga 8 28 CVD CVD NNP cord-336256-d5292aga 8 29 . . . cord-336256-d5292aga 9 1 Schomburg Schomburg NNP cord-336256-d5292aga 9 2 et et NNP cord-336256-d5292aga 9 3 al al NNP cord-336256-d5292aga 9 4 . . . cord-336256-d5292aga 10 1 identified identify VBN cord-336256-d5292aga 10 2 , , , cord-336256-d5292aga 10 3 in in IN cord-336256-d5292aga 10 4 a a DT cord-336256-d5292aga 10 5 Swedish swedish JJ cord-336256-d5292aga 10 6 human human JJ cord-336256-d5292aga 10 7 perspective perspective NN cord-336256-d5292aga 10 8 cohort cohort NN cord-336256-d5292aga 10 9 , , , cord-336256-d5292aga 10 10 a a DT cord-336256-d5292aga 10 11 strong strong JJ cord-336256-d5292aga 10 12 correlation correlation NN cord-336256-d5292aga 10 13 between between IN cord-336256-d5292aga 10 14 low low JJ cord-336256-d5292aga 10 15 baseline baseline JJ cord-336256-d5292aga 10 16 plasma plasma NN cord-336256-d5292aga 10 17 levels level NNS cord-336256-d5292aga 10 18 of of IN cord-336256-d5292aga 10 19 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 10 20 P P NNP cord-336256-d5292aga 10 21 ( ( -LRB- cord-336256-d5292aga 10 22 SELENOP SELENOP NNP cord-336256-d5292aga 10 23 ; ; : cord-336256-d5292aga 10 24 the the DT cord-336256-d5292aga 10 25 major major JJ cord-336256-d5292aga 10 26 Se Se NNP cord-336256-d5292aga 10 27 - - HYPH cord-336256-d5292aga 10 28 transporter transporter NN cord-336256-d5292aga 10 29 ) ) -RRB- cord-336256-d5292aga 10 30 and and CC cord-336256-d5292aga 10 31 risk risk NN cord-336256-d5292aga 10 32 for for IN cord-336256-d5292aga 10 33 all all DT cord-336256-d5292aga 10 34 - - HYPH cord-336256-d5292aga 10 35 cause cause NN cord-336256-d5292aga 10 36 mortality mortality NN cord-336256-d5292aga 10 37 , , , cord-336256-d5292aga 10 38 CVD CVD NNP cord-336256-d5292aga 10 39 mortality mortality NN cord-336256-d5292aga 10 40 , , , cord-336256-d5292aga 10 41 and and CC cord-336256-d5292aga 10 42 a a DT cord-336256-d5292aga 10 43 first first JJ cord-336256-d5292aga 10 44 CVD CVD NNP cord-336256-d5292aga 10 45 event event NN cord-336256-d5292aga 10 46 during during IN cord-336256-d5292aga 10 47 the the DT cord-336256-d5292aga 10 48 follow follow NN cord-336256-d5292aga 10 49 - - HYPH cord-336256-d5292aga 10 50 up up NN cord-336256-d5292aga 10 51 period period NN cord-336256-d5292aga 10 52 of of IN cord-336256-d5292aga 10 53 9.3 9.3 CD cord-336256-d5292aga 10 54 ( ( -LRB- cord-336256-d5292aga 10 55 8.3 8.3 CD cord-336256-d5292aga 10 56 - - SYM cord-336256-d5292aga 10 57 11 11 CD cord-336256-d5292aga 10 58 ) ) -RRB- cord-336256-d5292aga 10 59 years year NNS cord-336256-d5292aga 10 60 [ [ -LRB- cord-336256-d5292aga 10 61 2 2 CD cord-336256-d5292aga 10 62 ] ] -RRB- cord-336256-d5292aga 10 63 . . . cord-336256-d5292aga 11 1 Based base VBN cord-336256-d5292aga 11 2 on on IN cord-336256-d5292aga 11 3 the the DT cord-336256-d5292aga 11 4 known know VBN cord-336256-d5292aga 11 5 high high JJ cord-336256-d5292aga 11 6 prevalence prevalence NN cord-336256-d5292aga 11 7 ( ( -LRB- cord-336256-d5292aga 11 8 20 20 CD cord-336256-d5292aga 11 9 % % NN cord-336256-d5292aga 11 10 ) ) -RRB- cord-336256-d5292aga 11 11 of of IN cord-336256-d5292aga 11 12 low low JJ cord-336256-d5292aga 11 13 SELENOP SELENOP NNP cord-336256-d5292aga 11 14 levels level NNS cord-336256-d5292aga 11 15 in in IN cord-336256-d5292aga 11 16 the the DT cord-336256-d5292aga 11 17 Northern northern JJ cord-336256-d5292aga 11 18 European european JJ cord-336256-d5292aga 11 19 population population NN cord-336256-d5292aga 11 20 [ [ -LRB- cord-336256-d5292aga 11 21 2 2 CD cord-336256-d5292aga 11 22 , , , cord-336256-d5292aga 11 23 3 3 CD cord-336256-d5292aga 11 24 ] ] -RRB- cord-336256-d5292aga 11 25 , , , cord-336256-d5292aga 11 26 these these DT cord-336256-d5292aga 11 27 data datum NNS cord-336256-d5292aga 11 28 suggest suggest VBP cord-336256-d5292aga 11 29 that that IN cord-336256-d5292aga 11 30 plasma plasma NN cord-336256-d5292aga 11 31 SELENOP selenop NN cord-336256-d5292aga 11 32 concentrations concentration NNS cord-336256-d5292aga 11 33 may may MD cord-336256-d5292aga 11 34 be be VB cord-336256-d5292aga 11 35 used use VBN cord-336256-d5292aga 11 36 as as IN cord-336256-d5292aga 11 37 an an DT cord-336256-d5292aga 11 38 early early JJ cord-336256-d5292aga 11 39 biomarker biomarker NN cord-336256-d5292aga 11 40 of of IN cord-336256-d5292aga 11 41 CVD CVD NNP cord-336256-d5292aga 11 42 risk risk NN cord-336256-d5292aga 11 43 and and CC cord-336256-d5292aga 11 44 , , , cord-336256-d5292aga 11 45 therefore therefore RB cord-336256-d5292aga 11 46 , , , cord-336256-d5292aga 11 47 that that DT cord-336256-d5292aga 11 48 targeted target VBD cord-336256-d5292aga 11 49 Se Se NNP cord-336256-d5292aga 11 50 supplementation supplementation NN cord-336256-d5292aga 11 51 could could MD cord-336256-d5292aga 11 52 be be VB cord-336256-d5292aga 11 53 used use VBN cord-336256-d5292aga 11 54 as as IN cord-336256-d5292aga 11 55 a a DT cord-336256-d5292aga 11 56 preventative preventative JJ cord-336256-d5292aga 11 57 measure measure NN cord-336256-d5292aga 11 58 . . . cord-336256-d5292aga 12 1 However however RB cord-336256-d5292aga 12 2 , , , cord-336256-d5292aga 12 3 further further JJ cord-336256-d5292aga 12 4 studies study NNS cord-336256-d5292aga 12 5 are be VBP cord-336256-d5292aga 12 6 required require VBN cord-336256-d5292aga 12 7 to to TO cord-336256-d5292aga 12 8 determine determine VB cord-336256-d5292aga 12 9 the the DT cord-336256-d5292aga 12 10 causal causal JJ cord-336256-d5292aga 12 11 link link NN cord-336256-d5292aga 12 12 between between IN cord-336256-d5292aga 12 13 SELENOP SELENOP NNP cord-336256-d5292aga 12 14 levels level NNS cord-336256-d5292aga 12 15 and and CC cord-336256-d5292aga 12 16 cardiovascular cardiovascular JJ cord-336256-d5292aga 12 17 events event NNS cord-336256-d5292aga 12 18 and and CC cord-336256-d5292aga 12 19 to to TO cord-336256-d5292aga 12 20 assess assess VB cord-336256-d5292aga 12 21 whether whether IN cord-336256-d5292aga 12 22 genetic genetic JJ cord-336256-d5292aga 12 23 variants variant NNS cord-336256-d5292aga 12 24 in in IN cord-336256-d5292aga 12 25 the the DT cord-336256-d5292aga 12 26 SELENOP SELENOP NNP cord-336256-d5292aga 12 27 gene gene NN cord-336256-d5292aga 12 28 , , , cord-336256-d5292aga 12 29 known know VBN cord-336256-d5292aga 12 30 to to TO cord-336256-d5292aga 12 31 influence influence VB cord-336256-d5292aga 12 32 Se Se NNP cord-336256-d5292aga 12 33 bioavailability bioavailability NN cord-336256-d5292aga 12 34 , , , cord-336256-d5292aga 12 35 affects affect VBZ cord-336256-d5292aga 12 36 this this DT cord-336256-d5292aga 12 37 correlation correlation NN cord-336256-d5292aga 12 38 . . . cord-336256-d5292aga 13 1 Non Non NNP cord-336256-d5292aga 13 2 - - JJ cord-336256-d5292aga 13 3 selenoprotein selenoprotein JJ cord-336256-d5292aga 13 4 Se Se NNP cord-336256-d5292aga 13 5 - - HYPH cord-336256-d5292aga 13 6 binding bind VBG cord-336256-d5292aga 13 7 proteins protein NNS cord-336256-d5292aga 13 8 , , , cord-336256-d5292aga 13 9 such such JJ cord-336256-d5292aga 13 10 as as IN cord-336256-d5292aga 13 11 Selenium Selenium NNP cord-336256-d5292aga 13 12 - - HYPH cord-336256-d5292aga 13 13 Binding bind VBG cord-336256-d5292aga 13 14 Protein Protein NNP cord-336256-d5292aga 13 15 1 1 CD cord-336256-d5292aga 13 16 ( ( -LRB- cord-336256-d5292aga 13 17 SELENBP1 SELENBP1 NNS cord-336256-d5292aga 13 18 ) ) -RRB- cord-336256-d5292aga 13 19 , , , cord-336256-d5292aga 13 20 have have VBP cord-336256-d5292aga 13 21 been be VBN cord-336256-d5292aga 13 22 underappreciated underappreciate VBN cord-336256-d5292aga 13 23 in in IN cord-336256-d5292aga 13 24 Se Se NNP cord-336256-d5292aga 13 25 - - HYPH cord-336256-d5292aga 13 26 related relate VBN cord-336256-d5292aga 13 27 research research NN cord-336256-d5292aga 13 28 , , , cord-336256-d5292aga 13 29 considering consider VBG cord-336256-d5292aga 13 30 their -PRON- PRP$ cord-336256-d5292aga 13 31 significant significant JJ cord-336256-d5292aga 13 32 relevance relevance NN cord-336256-d5292aga 13 33 for for IN cord-336256-d5292aga 13 34 major major JJ cord-336256-d5292aga 13 35 physiological physiological JJ cord-336256-d5292aga 13 36 processes process NNS cord-336256-d5292aga 13 37 and and CC cord-336256-d5292aga 13 38 that that IN cord-336256-d5292aga 13 39 SELENBP1 SELENBP1 NNP cord-336256-d5292aga 13 40 has have VBZ cord-336256-d5292aga 13 41 been be VBN cord-336256-d5292aga 13 42 previously previously RB cord-336256-d5292aga 13 43 implicated implicate VBN cord-336256-d5292aga 13 44 in in IN cord-336256-d5292aga 13 45 myocardial myocardial JJ cord-336256-d5292aga 13 46 infarction infarction NN cord-336256-d5292aga 13 47 and and CC cord-336256-d5292aga 13 48 poor poor JJ cord-336256-d5292aga 13 49 clinical clinical JJ cord-336256-d5292aga 13 50 outcomes outcome NNS cord-336256-d5292aga 13 51 from from IN cord-336256-d5292aga 13 52 various various JJ cord-336256-d5292aga 13 53 tumour tumour NN cord-336256-d5292aga 13 54 types type NNS cord-336256-d5292aga 13 55 [ [ -LRB- cord-336256-d5292aga 13 56 1 1 CD cord-336256-d5292aga 13 57 ] ] -RRB- cord-336256-d5292aga 13 58 . . . cord-336256-d5292aga 14 1 In in IN cord-336256-d5292aga 14 2 a a DT cord-336256-d5292aga 14 3 distinct distinct JJ cord-336256-d5292aga 14 4 cohort cohort NN cord-336256-d5292aga 14 5 of of IN cord-336256-d5292aga 14 6 75 75 CD cord-336256-d5292aga 14 7 German german JJ cord-336256-d5292aga 14 8 patients patient NNS cord-336256-d5292aga 14 9 undergoing undergo VBG cord-336256-d5292aga 14 10 elective elective JJ cord-336256-d5292aga 14 11 cardiac cardiac JJ cord-336256-d5292aga 14 12 surgery surgery NN cord-336256-d5292aga 14 13 , , , cord-336256-d5292aga 14 14 a a DT cord-336256-d5292aga 14 15 marked marked JJ cord-336256-d5292aga 14 16 but but CC cord-336256-d5292aga 14 17 transient transient JJ cord-336256-d5292aga 14 18 increase increase NN cord-336256-d5292aga 14 19 in in IN cord-336256-d5292aga 14 20 circulating circulate VBG cord-336256-d5292aga 14 21 SELENBP1 SELENBP1 NNS cord-336256-d5292aga 14 22 concentrations concentration NNS cord-336256-d5292aga 14 23 during during IN cord-336256-d5292aga 14 24 the the DT cord-336256-d5292aga 14 25 surgical surgical JJ cord-336256-d5292aga 14 26 process process NN cord-336256-d5292aga 14 27 was be VBD cord-336256-d5292aga 14 28 correlated correlate VBN cord-336256-d5292aga 14 29 , , , cord-336256-d5292aga 14 30 in in IN cord-336256-d5292aga 14 31 most most JJS cord-336256-d5292aga 14 32 patients patient NNS cord-336256-d5292aga 14 33 , , , cord-336256-d5292aga 14 34 with with IN cord-336256-d5292aga 14 35 the the DT cord-336256-d5292aga 14 36 duration duration NN cord-336256-d5292aga 14 37 of of IN cord-336256-d5292aga 14 38 ischemia ischemia NN cord-336256-d5292aga 14 39 and and CC cord-336256-d5292aga 14 40 myocardial myocardial JJ cord-336256-d5292aga 14 41 damage damage NN cord-336256-d5292aga 14 42 . . . cord-336256-d5292aga 15 1 This this DT cord-336256-d5292aga 15 2 suggests suggest VBZ cord-336256-d5292aga 15 3 that that IN cord-336256-d5292aga 15 4 serum serum NN cord-336256-d5292aga 15 5 concentrations concentration NNS cord-336256-d5292aga 15 6 of of IN cord-336256-d5292aga 15 7 SELENBP1 SELENBP1 NNS cord-336256-d5292aga 15 8 could could MD cord-336256-d5292aga 15 9 constitute constitute VB cord-336256-d5292aga 15 10 a a DT cord-336256-d5292aga 15 11 quantitative quantitative JJ cord-336256-d5292aga 15 12 marker marker NN cord-336256-d5292aga 15 13 for for IN cord-336256-d5292aga 15 14 myocardial myocardial JJ cord-336256-d5292aga 15 15 hypoxia hypoxia NN cord-336256-d5292aga 15 16 [ [ -LRB- cord-336256-d5292aga 15 17 1 1 CD cord-336256-d5292aga 15 18 ] ] -RRB- cord-336256-d5292aga 15 19 . . . cord-336256-d5292aga 16 1 On on IN cord-336256-d5292aga 16 2 the the DT cord-336256-d5292aga 16 3 contrary contrary JJ cord-336256-d5292aga 16 4 , , , cord-336256-d5292aga 16 5 high high JJ cord-336256-d5292aga 16 6 serum serum NN cord-336256-d5292aga 16 7 Se Se NNP cord-336256-d5292aga 16 8 levels level NNS cord-336256-d5292aga 16 9 were be VBD cord-336256-d5292aga 16 10 associated associate VBN cord-336256-d5292aga 16 11 with with IN cord-336256-d5292aga 16 12 metabolic metabolic JJ cord-336256-d5292aga 16 13 syndrome syndrome NN cord-336256-d5292aga 16 14 and and CC cord-336256-d5292aga 16 15 insulin insulin NN cord-336256-d5292aga 16 16 resistance resistance NN cord-336256-d5292aga 16 17 markers marker NNS cord-336256-d5292aga 16 18 in in IN cord-336256-d5292aga 16 19 a a DT cord-336256-d5292aga 16 20 large large JJ cord-336256-d5292aga 16 21 Taiwanese taiwanese JJ cord-336256-d5292aga 16 22 cohort cohort NN cord-336256-d5292aga 16 23 , , , cord-336256-d5292aga 16 24 although although IN cord-336256-d5292aga 16 25 markers marker NNS cord-336256-d5292aga 16 26 of of IN cord-336256-d5292aga 16 27 adiposity adiposity NN cord-336256-d5292aga 16 28 and and CC cord-336256-d5292aga 16 29 lipid lipid NN cord-336256-d5292aga 16 30 functions function NNS cord-336256-d5292aga 16 31 varied vary VBN cord-336256-d5292aga 16 32 by by IN cord-336256-d5292aga 16 33 sex sex NN cord-336256-d5292aga 16 34 [ [ -LRB- cord-336256-d5292aga 16 35 5 5 CD cord-336256-d5292aga 16 36 ] ] -RRB- cord-336256-d5292aga 16 37 . . . cord-336256-d5292aga 17 1 Further further JJ cord-336256-d5292aga 17 2 evidence evidence NN cord-336256-d5292aga 17 3 of of IN cord-336256-d5292aga 17 4 the the DT cord-336256-d5292aga 17 5 importance importance NN cord-336256-d5292aga 17 6 of of IN cord-336256-d5292aga 17 7 Se Se NNP cord-336256-d5292aga 17 8 in in IN cord-336256-d5292aga 17 9 lipid lipid NN cord-336256-d5292aga 17 10 and and CC cord-336256-d5292aga 17 11 energy energy NN cord-336256-d5292aga 17 12 metabolism metabolism NN cord-336256-d5292aga 17 13 is be VBZ cord-336256-d5292aga 17 14 supported support VBN cord-336256-d5292aga 17 15 by by IN cord-336256-d5292aga 17 16 the the DT cord-336256-d5292aga 17 17 observation observation NN cord-336256-d5292aga 17 18 that that IN cord-336256-d5292aga 17 19 the the DT cord-336256-d5292aga 17 20 enzyme enzyme NN cord-336256-d5292aga 17 21 selenocysteine selenocysteine NN cord-336256-d5292aga 17 22 lyase lyase NN cord-336256-d5292aga 17 23 ( ( -LRB- cord-336256-d5292aga 17 24 Scly Scly NNP cord-336256-d5292aga 17 25 ) ) -RRB- cord-336256-d5292aga 17 26 is be VBZ cord-336256-d5292aga 17 27 involved involve VBN cord-336256-d5292aga 17 28 in in IN cord-336256-d5292aga 17 29 weight weight NN cord-336256-d5292aga 17 30 gain gain NN cord-336256-d5292aga 17 31 , , , cord-336256-d5292aga 17 32 resistance resistance NN cord-336256-d5292aga 17 33 to to IN cord-336256-d5292aga 17 34 anorexigenic anorexigenic NNP cord-336256-d5292aga 17 35 hormone hormone NN cord-336256-d5292aga 17 36 leptin leptin NN cord-336256-d5292aga 17 37 , , , cord-336256-d5292aga 17 38 and and CC cord-336256-d5292aga 17 39 thermogenesis thermogenesis NN cord-336256-d5292aga 17 40 [ [ -LRB- cord-336256-d5292aga 17 41 7 7 CD cord-336256-d5292aga 17 42 ] ] -RRB- cord-336256-d5292aga 17 43 . . . cord-336256-d5292aga 18 1 Scly Scly NNP cord-336256-d5292aga 18 2 is be VBZ cord-336256-d5292aga 18 3 responsible responsible JJ cord-336256-d5292aga 18 4 for for IN cord-336256-d5292aga 18 5 the the DT cord-336256-d5292aga 18 6 breakdown breakdown NN cord-336256-d5292aga 18 7 of of IN cord-336256-d5292aga 18 8 intracellular intracellular JJ cord-336256-d5292aga 18 9 selenocysteine selenocysteine NN cord-336256-d5292aga 18 10 to to IN cord-336256-d5292aga 18 11 alanine alanine NN cord-336256-d5292aga 18 12 and and CC cord-336256-d5292aga 18 13 selenide selenide NN cord-336256-d5292aga 18 14 , , , cord-336256-d5292aga 18 15 which which WDT cord-336256-d5292aga 18 16 is be VBZ cord-336256-d5292aga 18 17 in in IN cord-336256-d5292aga 18 18 turn turn NN cord-336256-d5292aga 18 19 recycled recycle VBN cord-336256-d5292aga 18 20 for for IN cord-336256-d5292aga 18 21 the the DT cord-336256-d5292aga 18 22 synthesis synthesis NN cord-336256-d5292aga 18 23 of of IN cord-336256-d5292aga 18 24 new new JJ cord-336256-d5292aga 18 25 selenoproteins selenoprotein NNS cord-336256-d5292aga 18 26 . . . cord-336256-d5292aga 19 1 The the DT cord-336256-d5292aga 19 2 conditional conditional JJ cord-336256-d5292aga 19 3 Scly Scly NNP cord-336256-d5292aga 19 4 knockout knockout NN cord-336256-d5292aga 19 5 ( ( -LRB- cord-336256-d5292aga 19 6 KO KO NNP cord-336256-d5292aga 19 7 ) ) -RRB- cord-336256-d5292aga 19 8 model model NN cord-336256-d5292aga 19 9 affecting affect VBG cord-336256-d5292aga 19 10 agouti agouti NN cord-336256-d5292aga 19 11 - - HYPH cord-336256-d5292aga 19 12 related relate VBN cord-336256-d5292aga 19 13 peptide peptide NN cord-336256-d5292aga 19 14 - - HYPH cord-336256-d5292aga 19 15 positive positive JJ cord-336256-d5292aga 19 16 neurons neuron NNS cord-336256-d5292aga 19 17 in in IN cord-336256-d5292aga 19 18 the the DT cord-336256-d5292aga 19 19 hypothalamus hypothalamus NN cord-336256-d5292aga 19 20 ( ( -LRB- cord-336256-d5292aga 19 21 Scly Scly NNP cord-336256-d5292aga 19 22 - - HYPH cord-336256-d5292aga 19 23 Agrp Agrp NNP cord-336256-d5292aga 19 24 KO KO NNP cord-336256-d5292aga 19 25 mice mouse NNS cord-336256-d5292aga 19 26 ) ) -RRB- cord-336256-d5292aga 19 27 displayed display VBD cord-336256-d5292aga 19 28 a a DT cord-336256-d5292aga 19 29 reduction reduction NN cord-336256-d5292aga 19 30 in in IN cord-336256-d5292aga 19 31 high high JJ cord-336256-d5292aga 19 32 fat fat NN cord-336256-d5292aga 19 33 diet diet NN cord-336256-d5292aga 19 34 - - HYPH cord-336256-d5292aga 19 35 induced induce VBN cord-336256-d5292aga 19 36 weight weight NN cord-336256-d5292aga 19 37 gain gain NN cord-336256-d5292aga 19 38 and and CC cord-336256-d5292aga 19 39 protection protection NN cord-336256-d5292aga 19 40 against against IN cord-336256-d5292aga 19 41 development development NN cord-336256-d5292aga 19 42 of of IN cord-336256-d5292aga 19 43 leptin leptin NN cord-336256-d5292aga 19 44 resistance resistance NN cord-336256-d5292aga 19 45 compared compare VBN cord-336256-d5292aga 19 46 with with IN cord-336256-d5292aga 19 47 controls control NNS cord-336256-d5292aga 19 48 ( ( -LRB- cord-336256-d5292aga 19 49 mice mouse NNS cord-336256-d5292aga 19 50 expressing express VBG cord-336256-d5292aga 19 51 Scly Scly NNP cord-336256-d5292aga 19 52 ) ) -RRB- cord-336256-d5292aga 19 53 . . . cord-336256-d5292aga 20 1 This this DT cord-336256-d5292aga 20 2 was be VBD cord-336256-d5292aga 20 3 linked link VBN cord-336256-d5292aga 20 4 to to IN cord-336256-d5292aga 20 5 progressive progressive JJ cord-336256-d5292aga 20 6 degeneration degeneration NN cord-336256-d5292aga 20 7 of of IN cord-336256-d5292aga 20 8 some some DT cord-336256-d5292aga 20 9 Agrp Agrp NNP cord-336256-d5292aga 20 10 neurons neuron NNS cord-336256-d5292aga 20 11 and and CC cord-336256-d5292aga 20 12 in in IN cord-336256-d5292aga 20 13 brown brown JJ cord-336256-d5292aga 20 14 adipose adipose JJ cord-336256-d5292aga 20 15 tissue tissue NN cord-336256-d5292aga 20 16 pattern pattern NN cord-336256-d5292aga 20 17 [ [ -LRB- cord-336256-d5292aga 20 18 7 7 CD cord-336256-d5292aga 20 19 ] ] -RRB- cord-336256-d5292aga 20 20 . . . cord-336256-d5292aga 21 1 Taken take VBN cord-336256-d5292aga 21 2 together together RB cord-336256-d5292aga 21 3 , , , cord-336256-d5292aga 21 4 these these DT cord-336256-d5292aga 21 5 data datum NNS cord-336256-d5292aga 21 6 provide provide VBP cord-336256-d5292aga 21 7 some some DT cord-336256-d5292aga 21 8 novel novel JJ cord-336256-d5292aga 21 9 potential potential JJ cord-336256-d5292aga 21 10 targets target NNS cord-336256-d5292aga 21 11 for for IN cord-336256-d5292aga 21 12 understanding understand VBG cord-336256-d5292aga 21 13 the the DT cord-336256-d5292aga 21 14 mechanisms mechanism NNS cord-336256-d5292aga 21 15 by by IN cord-336256-d5292aga 21 16 which which WDT cord-336256-d5292aga 21 17 Se Se NNP cord-336256-d5292aga 21 18 affects affect VBZ cord-336256-d5292aga 21 19 CVD CVD NNP cord-336256-d5292aga 21 20 or or CC cord-336256-d5292aga 21 21 lipid lipid NN cord-336256-d5292aga 21 22 metabolism metabolism NN cord-336256-d5292aga 21 23 and and CC cord-336256-d5292aga 21 24 for for IN cord-336256-d5292aga 21 25 further further RB cord-336256-d5292aga 21 26 investigating investigate VBG cord-336256-d5292aga 21 27 the the DT cord-336256-d5292aga 21 28 potential potential NN cord-336256-d5292aga 21 29 of of IN cord-336256-d5292aga 21 30 SELENOP SELENOP NNP cord-336256-d5292aga 21 31 and and CC cord-336256-d5292aga 21 32 SELENBP1 SELENBP1 NNS cord-336256-d5292aga 21 33 as as IN cord-336256-d5292aga 21 34 CVD CVD NNP cord-336256-d5292aga 21 35 biomarkers biomarker NNS cord-336256-d5292aga 21 36 . . . cord-336256-d5292aga 22 1 Accumulating accumulate VBG cord-336256-d5292aga 22 2 experimental experimental JJ cord-336256-d5292aga 22 3 and and CC cord-336256-d5292aga 22 4 observational observational JJ cord-336256-d5292aga 22 5 evidence evidence NN cord-336256-d5292aga 22 6 suggests suggest VBZ cord-336256-d5292aga 22 7 that that IN cord-336256-d5292aga 22 8 insufficient insufficient JJ cord-336256-d5292aga 22 9 Se Se NNP cord-336256-d5292aga 22 10 intake intake NN cord-336256-d5292aga 22 11 and/or and/or CC cord-336256-d5292aga 22 12 selenoprotein selenoprotein NNP cord-336256-d5292aga 22 13 genetic genetic JJ cord-336256-d5292aga 22 14 variations variation NNS cord-336256-d5292aga 22 15 may may MD cord-336256-d5292aga 22 16 contribute contribute VB cord-336256-d5292aga 22 17 to to IN cord-336256-d5292aga 22 18 the the DT cord-336256-d5292aga 22 19 development development NN cord-336256-d5292aga 22 20 of of IN cord-336256-d5292aga 22 21 several several JJ cord-336256-d5292aga 22 22 tumours tumour NNS cord-336256-d5292aga 22 23 including include VBG cord-336256-d5292aga 22 24 colorectal colorectal JJ cord-336256-d5292aga 22 25 cancer cancer NN cord-336256-d5292aga 22 26 ( ( -LRB- cord-336256-d5292aga 22 27 CRC CRC NNP cord-336256-d5292aga 22 28 ) ) -RRB- cord-336256-d5292aga 22 29 , , , cord-336256-d5292aga 22 30 mediated mediate VBN cord-336256-d5292aga 22 31 by by IN cord-336256-d5292aga 22 32 oxidative oxidative JJ cord-336256-d5292aga 22 33 and and CC cord-336256-d5292aga 22 34 inflammatory inflammatory JJ cord-336256-d5292aga 22 35 stress stress NN cord-336256-d5292aga 22 36 response response NN cord-336256-d5292aga 22 37 selenoproteins selenoprotein NNS cord-336256-d5292aga 22 38 [ [ -LRB- cord-336256-d5292aga 22 39 3 3 CD cord-336256-d5292aga 22 40 ] ] -RRB- cord-336256-d5292aga 22 41 . . . cord-336256-d5292aga 23 1 Higher high JJR cord-336256-d5292aga 23 2 Se Se NNP cord-336256-d5292aga 23 3 status status NN cord-336256-d5292aga 23 4 levels level NNS cord-336256-d5292aga 23 5 ( ( -LRB- cord-336256-d5292aga 23 6 total total JJ cord-336256-d5292aga 23 7 serum serum NN cord-336256-d5292aga 23 8 Se Se NNP cord-336256-d5292aga 23 9 levels level NNS cord-336256-d5292aga 23 10 and and CC cord-336256-d5292aga 23 11 SELENOP SELENOP NNP cord-336256-d5292aga 23 12 concentrations concentration NNS cord-336256-d5292aga 23 13 ) ) -RRB- cord-336256-d5292aga 23 14 were be VBD cord-336256-d5292aga 23 15 previously previously RB cord-336256-d5292aga 23 16 reported report VBN cord-336256-d5292aga 23 17 in in IN cord-336256-d5292aga 23 18 a a DT cord-336256-d5292aga 23 19 multi multi JJ cord-336256-d5292aga 23 20 - - JJ cord-336256-d5292aga 23 21 centre centre JJ cord-336256-d5292aga 23 22 , , , cord-336256-d5292aga 23 23 European european JJ cord-336256-d5292aga 23 24 prospective prospective JJ cord-336256-d5292aga 23 25 cohort cohort NN cord-336256-d5292aga 23 26 study study NN cord-336256-d5292aga 23 27 ( ( -LRB- cord-336256-d5292aga 23 28 EPIC EPIC NNP cord-336256-d5292aga 23 29 ) ) -RRB- cord-336256-d5292aga 24 1 to to TO cord-336256-d5292aga 24 2 be be VB cord-336256-d5292aga 24 3 associated associate VBN cord-336256-d5292aga 24 4 with with IN cord-336256-d5292aga 24 5 a a DT cord-336256-d5292aga 24 6 decreased decrease VBN cord-336256-d5292aga 24 7 CRC CRC NNP cord-336256-d5292aga 24 8 risk risk NN cord-336256-d5292aga 24 9 . . . cord-336256-d5292aga 25 1 The the DT cord-336256-d5292aga 25 2 manuscript manuscript NN cord-336256-d5292aga 25 3 in in IN cord-336256-d5292aga 25 4 this this DT cord-336256-d5292aga 25 5 issue issue NN cord-336256-d5292aga 25 6 by by IN cord-336256-d5292aga 25 7 Fedirko Fedirko NNP cord-336256-d5292aga 25 8 et et NNP cord-336256-d5292aga 25 9 al al NNP cord-336256-d5292aga 25 10 . . NNP cord-336256-d5292aga 25 11 extends extend VBZ cord-336256-d5292aga 25 12 this this DT cord-336256-d5292aga 25 13 work work NN cord-336256-d5292aga 25 14 by by IN cord-336256-d5292aga 25 15 describing describe VBG cord-336256-d5292aga 25 16 the the DT cord-336256-d5292aga 25 17 largest large JJS cord-336256-d5292aga 25 18 association association NN cord-336256-d5292aga 25 19 with with IN cord-336256-d5292aga 25 20 CRC CRC NNP cord-336256-d5292aga 25 21 risk risk NN cord-336256-d5292aga 25 22 for for IN cord-336256-d5292aga 25 23 common common JJ cord-336256-d5292aga 25 24 genetic genetic JJ cord-336256-d5292aga 25 25 variations variation NNS cord-336256-d5292aga 25 26 related relate VBN cord-336256-d5292aga 25 27 to to IN cord-336256-d5292aga 25 28 Se Se NNP cord-336256-d5292aga 25 29 metabolism metabolism NN cord-336256-d5292aga 25 30 in in IN cord-336256-d5292aga 25 31 approximately approximately RB cord-336256-d5292aga 25 32 1400 1400 CD cord-336256-d5292aga 25 33 cases case NNS cord-336256-d5292aga 25 34 and and CC cord-336256-d5292aga 25 35 1400 1400 CD cord-336256-d5292aga 25 36 controls control NNS cord-336256-d5292aga 25 37 within within IN cord-336256-d5292aga 25 38 this this DT cord-336256-d5292aga 25 39 EPIC EPIC NNP cord-336256-d5292aga 25 40 cohort cohort NN cord-336256-d5292aga 25 41 . . . cord-336256-d5292aga 26 1 The the DT cord-336256-d5292aga 26 2 study study NN cord-336256-d5292aga 26 3 examined examine VBD cord-336256-d5292aga 26 4 over over IN cord-336256-d5292aga 26 5 1000 1000 CD cord-336256-d5292aga 26 6 single single JJ cord-336256-d5292aga 26 7 nucleotide nucleotide JJ cord-336256-d5292aga 26 8 polymorphisms polymorphism NNS cord-336256-d5292aga 26 9 ( ( -LRB- cord-336256-d5292aga 26 10 SNPs SNPs NNP cord-336256-d5292aga 26 11 ) ) -RRB- cord-336256-d5292aga 26 12 in in IN cord-336256-d5292aga 26 13 154 154 CD cord-336256-d5292aga 26 14 genes gene NNS cord-336256-d5292aga 26 15 within within IN cord-336256-d5292aga 26 16 the the DT cord-336256-d5292aga 26 17 Se Se NNP cord-336256-d5292aga 26 18 biological biological JJ cord-336256-d5292aga 26 19 pathway pathway NN cord-336256-d5292aga 26 20 ( ( -LRB- cord-336256-d5292aga 26 21 including include VBG cord-336256-d5292aga 26 22 all all DT cord-336256-d5292aga 26 23 selenoprotein selenoprotein NNP cord-336256-d5292aga 26 24 genes gene NNS cord-336256-d5292aga 26 25 and and CC cord-336256-d5292aga 26 26 Se Se NNP cord-336256-d5292aga 26 27 metabolic metabolic JJ cord-336256-d5292aga 26 28 pathway pathway NN cord-336256-d5292aga 26 29 genes gene NNS cord-336256-d5292aga 26 30 ) ) -RRB- cord-336256-d5292aga 26 31 and and CC cord-336256-d5292aga 26 32 interactions interaction NNS cord-336256-d5292aga 26 33 with with IN cord-336256-d5292aga 26 34 serum serum NN cord-336256-d5292aga 26 35 Se Se NNP cord-336256-d5292aga 26 36 status status NN cord-336256-d5292aga 26 37 biomarkers biomarker NNS cord-336256-d5292aga 26 38 from from IN cord-336256-d5292aga 26 39 the the DT cord-336256-d5292aga 26 40 previous previous JJ cord-336256-d5292aga 26 41 study study NN cord-336256-d5292aga 26 42 . . . cord-336256-d5292aga 27 1 The the DT cord-336256-d5292aga 27 2 findings finding NNS cord-336256-d5292aga 27 3 provide provide VBP cord-336256-d5292aga 27 4 the the DT cord-336256-d5292aga 27 5 most most RBS cord-336256-d5292aga 27 6 comprehensive comprehensive JJ cord-336256-d5292aga 27 7 evidence evidence NN cord-336256-d5292aga 27 8 to to IN cord-336256-d5292aga 27 9 date date NN cord-336256-d5292aga 27 10 that that IN cord-336256-d5292aga 27 11 individual individual JJ cord-336256-d5292aga 27 12 genotypes genotype NNS cord-336256-d5292aga 27 13 relevant relevant JJ cord-336256-d5292aga 27 14 for for IN cord-336256-d5292aga 27 15 selenoprotein selenoprotein NNP cord-336256-d5292aga 27 16 expression expression NN cord-336256-d5292aga 27 17 , , , cord-336256-d5292aga 27 18 metabolism metabolism NN cord-336256-d5292aga 27 19 , , , cord-336256-d5292aga 27 20 and and CC cord-336256-d5292aga 27 21 function function NN cord-336256-d5292aga 27 22 and and CC cord-336256-d5292aga 27 23 interaction interaction NN cord-336256-d5292aga 27 24 with with IN cord-336256-d5292aga 27 25 Se Se NNP cord-336256-d5292aga 27 26 status status NN cord-336256-d5292aga 27 27 may may MD cord-336256-d5292aga 27 28 affect affect VB cord-336256-d5292aga 27 29 CRC CRC NNP cord-336256-d5292aga 27 30 risk risk NN cord-336256-d5292aga 27 31 in in IN cord-336256-d5292aga 27 32 a a DT cord-336256-d5292aga 27 33 population population NN cord-336256-d5292aga 27 34 of of IN cord-336256-d5292aga 27 35 marginally marginally RB cord-336256-d5292aga 27 36 low low JJ cord-336256-d5292aga 27 37 Se Se NNP cord-336256-d5292aga 27 38 status status NN cord-336256-d5292aga 27 39 , , , cord-336256-d5292aga 27 40 such such JJ cord-336256-d5292aga 27 41 as as IN cord-336256-d5292aga 27 42 in in IN cord-336256-d5292aga 27 43 Europe Europe NNP cord-336256-d5292aga 27 44 . . . cord-336256-d5292aga 28 1 Pathway pathway NN cord-336256-d5292aga 28 2 analyses analysis NNS cord-336256-d5292aga 28 3 indicated indicate VBD cord-336256-d5292aga 28 4 that that IN cord-336256-d5292aga 28 5 , , , cord-336256-d5292aga 28 6 for for IN cord-336256-d5292aga 28 7 genes gene NNS cord-336256-d5292aga 28 8 in in IN cord-336256-d5292aga 28 9 antioxidant antioxidant NN cord-336256-d5292aga 28 10 / / SYM cord-336256-d5292aga 28 11 redox redox NN cord-336256-d5292aga 28 12 and and CC cord-336256-d5292aga 28 13 apoptotic apoptotic JJ cord-336256-d5292aga 28 14 pathways pathway NNS cord-336256-d5292aga 28 15 , , , cord-336256-d5292aga 28 16 the the DT cord-336256-d5292aga 28 17 influence influence NN cord-336256-d5292aga 28 18 of of IN cord-336256-d5292aga 28 19 SNPs SNPs NNPS cord-336256-d5292aga 28 20 on on IN cord-336256-d5292aga 28 21 the the DT cord-336256-d5292aga 28 22 disease disease NN cord-336256-d5292aga 28 23 risk risk NN cord-336256-d5292aga 28 24 is be VBZ cord-336256-d5292aga 28 25 also also RB cord-336256-d5292aga 28 26 dependent dependent JJ cord-336256-d5292aga 28 27 on on IN cord-336256-d5292aga 28 28 interaction interaction NN cord-336256-d5292aga 28 29 with with IN cord-336256-d5292aga 28 30 Se Se NNP cord-336256-d5292aga 28 31 status status NN cord-336256-d5292aga 28 32 [ [ -LRB- cord-336256-d5292aga 28 33 3 3 CD cord-336256-d5292aga 28 34 ] ] -RRB- cord-336256-d5292aga 28 35 . . . cord-336256-d5292aga 29 1 Addressing address VBG cord-336256-d5292aga 29 2 the the DT cord-336256-d5292aga 29 3 sparse sparse JJ cord-336256-d5292aga 29 4 data datum NNS cord-336256-d5292aga 29 5 on on IN cord-336256-d5292aga 29 6 selenoprotein selenoprotein JJ cord-336256-d5292aga 29 7 expression expression NN cord-336256-d5292aga 29 8 in in IN cord-336256-d5292aga 29 9 CRC CRC NNP cord-336256-d5292aga 29 10 , , , cord-336256-d5292aga 29 11 Hughes Hughes NNP cord-336256-d5292aga 29 12 and and CC cord-336256-d5292aga 29 13 colleagues colleague NNS cord-336256-d5292aga 29 14 assessed assess VBD cord-336256-d5292aga 29 15 selenoprotein selenoprotein NNP cord-336256-d5292aga 29 16 gene gene NNP cord-336256-d5292aga 29 17 transcript transcript NN cord-336256-d5292aga 29 18 levels level NNS cord-336256-d5292aga 29 19 in in IN cord-336256-d5292aga 29 20 the the DT cord-336256-d5292aga 29 21 neoplastic neoplastic JJ cord-336256-d5292aga 29 22 and and CC cord-336256-d5292aga 29 23 matched matched JJ cord-336256-d5292aga 29 24 mucosal mucosal JJ cord-336256-d5292aga 29 25 tissue tissue NN cord-336256-d5292aga 29 26 from from IN cord-336256-d5292aga 29 27 Irish irish JJ cord-336256-d5292aga 29 28 and and CC cord-336256-d5292aga 29 29 Czech czech JJ cord-336256-d5292aga 29 30 colorectal colorectal JJ cord-336256-d5292aga 29 31 adenoma adenoma NN cord-336256-d5292aga 29 32 ( ( -LRB- cord-336256-d5292aga 29 33 CRA CRA NNP cord-336256-d5292aga 29 34 ) ) -RRB- cord-336256-d5292aga 29 35 and and CC cord-336256-d5292aga 29 36 CRC CRC NNP cord-336256-d5292aga 29 37 patients patient NNS cord-336256-d5292aga 29 38 and and CC cord-336256-d5292aga 29 39 examined examine VBD cord-336256-d5292aga 29 40 the the DT cord-336256-d5292aga 29 41 interaction interaction NN cord-336256-d5292aga 29 42 with with IN cord-336256-d5292aga 29 43 Se Se NNP cord-336256-d5292aga 29 44 status status NN cord-336256-d5292aga 29 45 levels level NNS cord-336256-d5292aga 29 46 [ [ -LRB- cord-336256-d5292aga 29 47 6 6 CD cord-336256-d5292aga 29 48 ] ] -RRB- cord-336256-d5292aga 29 49 . . . cord-336256-d5292aga 30 1 Several several JJ cord-336256-d5292aga 30 2 selenoproteins selenoprotein NNS cord-336256-d5292aga 30 3 ( ( -LRB- cord-336256-d5292aga 30 4 including include VBG cord-336256-d5292aga 30 5 biological biological JJ cord-336256-d5292aga 30 6 stress stress NN cord-336256-d5292aga 30 7 response response NN cord-336256-d5292aga 30 8 and and CC cord-336256-d5292aga 30 9 Se Se NNP cord-336256-d5292aga 30 10 biosynthesis biosynthesis NN cord-336256-d5292aga 30 11 genes gene NNS cord-336256-d5292aga 30 12 ) ) -RRB- cord-336256-d5292aga 30 13 were be VBD cord-336256-d5292aga 30 14 differentially differentially RB cord-336256-d5292aga 30 15 expressed express VBN cord-336256-d5292aga 30 16 in in IN cord-336256-d5292aga 30 17 the the DT cord-336256-d5292aga 30 18 disease disease NN cord-336256-d5292aga 30 19 tissue tissue NN cord-336256-d5292aga 30 20 compared compare VBN cord-336256-d5292aga 30 21 to to IN cord-336256-d5292aga 30 22 the the DT cord-336256-d5292aga 30 23 normal normal JJ cord-336256-d5292aga 30 24 tissue tissue NN cord-336256-d5292aga 30 25 of of IN cord-336256-d5292aga 30 26 both both CC cord-336256-d5292aga 30 27 CRA CRA NNP cord-336256-d5292aga 30 28 and and CC cord-336256-d5292aga 30 29 CRC CRC NNP cord-336256-d5292aga 30 30 patients patient NNS cord-336256-d5292aga 30 31 , , , cord-336256-d5292aga 30 32 and and CC cord-336256-d5292aga 30 33 that that DT cord-336256-d5292aga 30 34 also also RB cord-336256-d5292aga 30 35 showed show VBD cord-336256-d5292aga 30 36 tumour tumour NN cord-336256-d5292aga 30 37 gene gene NN cord-336256-d5292aga 30 38 expression expression NN cord-336256-d5292aga 30 39 changes change NNS cord-336256-d5292aga 30 40 correlated correlate VBN cord-336256-d5292aga 30 41 to to IN cord-336256-d5292aga 30 42 levels level NNS cord-336256-d5292aga 30 43 of of IN cord-336256-d5292aga 30 44 Se Se NNP cord-336256-d5292aga 30 45 or or CC cord-336256-d5292aga 30 46 SELENOP SELENOP NNP cord-336256-d5292aga 30 47 . . . cord-336256-d5292aga 31 1 Across across IN cord-336256-d5292aga 31 2 the the DT cord-336256-d5292aga 31 3 disease disease NN cord-336256-d5292aga 31 4 tissues tissue NNS cord-336256-d5292aga 31 5 from from IN cord-336256-d5292aga 31 6 the the DT cord-336256-d5292aga 31 7 adenoma adenoma NN cord-336256-d5292aga 31 8 and and CC cord-336256-d5292aga 31 9 both both DT cord-336256-d5292aga 31 10 cancer cancer NN cord-336256-d5292aga 31 11 groups group NNS cord-336256-d5292aga 31 12 , , , cord-336256-d5292aga 31 13 GPX2 GPX2 NNP cord-336256-d5292aga 31 14 and and CC cord-336256-d5292aga 31 15 TXNRD3 txnrd3 NN cord-336256-d5292aga 31 16 exhibited exhibit VBD cord-336256-d5292aga 31 17 higher high JJR cord-336256-d5292aga 31 18 expression expression NN cord-336256-d5292aga 31 19 while while IN cord-336256-d5292aga 31 20 GPX3 GPX3 NNP cord-336256-d5292aga 31 21 , , , cord-336256-d5292aga 31 22 SELENOP SELENOP NNP cord-336256-d5292aga 31 23 , , , cord-336256-d5292aga 31 24 SELENOS SELENOS NNP cord-336256-d5292aga 31 25 , , , cord-336256-d5292aga 31 26 and and CC cord-336256-d5292aga 31 27 SEPHS2 SEPHS2 NNS cord-336256-d5292aga 31 28 showed show VBD cord-336256-d5292aga 31 29 lower low JJR cord-336256-d5292aga 31 30 expression expression NN cord-336256-d5292aga 31 31 . . . cord-336256-d5292aga 32 1 The the DT cord-336256-d5292aga 32 2 authors author NNS cord-336256-d5292aga 32 3 concluded conclude VBD cord-336256-d5292aga 32 4 that that IN cord-336256-d5292aga 32 5 selenoprotein selenoprotein NNP cord-336256-d5292aga 32 6 expression expression NN cord-336256-d5292aga 32 7 changes change NNS cord-336256-d5292aga 32 8 could could MD cord-336256-d5292aga 32 9 be be VB cord-336256-d5292aga 32 10 used use VBN cord-336256-d5292aga 32 11 as as IN cord-336256-d5292aga 32 12 biomarkers biomarker NNS cord-336256-d5292aga 32 13 of of IN cord-336256-d5292aga 32 14 functional functional JJ cord-336256-d5292aga 32 15 Se Se NNP cord-336256-d5292aga 32 16 status status NN cord-336256-d5292aga 32 17 and and CC cord-336256-d5292aga 32 18 the the DT cord-336256-d5292aga 32 19 colorectal colorectal JJ cord-336256-d5292aga 32 20 adenoma adenoma NN cord-336256-d5292aga 32 21 to to IN cord-336256-d5292aga 32 22 cancer cancer NN cord-336256-d5292aga 32 23 transition transition NN cord-336256-d5292aga 32 24 . . . cord-336256-d5292aga 33 1 In in IN cord-336256-d5292aga 33 2 survival survival NN cord-336256-d5292aga 33 3 analyses analysis NNS cord-336256-d5292aga 33 4 , , , cord-336256-d5292aga 33 5 only only RB cord-336256-d5292aga 33 6 a a DT cord-336256-d5292aga 33 7 higher high JJR cord-336256-d5292aga 33 8 SELENOF SELENOF NNP cord-336256-d5292aga 33 9 expression expression NN cord-336256-d5292aga 33 10 was be VBD cord-336256-d5292aga 33 11 associated associate VBN cord-336256-d5292aga 33 12 with with IN cord-336256-d5292aga 33 13 poorer poor JJR cord-336256-d5292aga 33 14 survival survival NN cord-336256-d5292aga 33 15 outcomes outcome NNS cord-336256-d5292aga 33 16 after after IN cord-336256-d5292aga 33 17 cancer cancer NN cord-336256-d5292aga 33 18 diagnosis diagnosis NN cord-336256-d5292aga 33 19 . . . cord-336256-d5292aga 34 1 Although although IN cord-336256-d5292aga 34 2 this this DT cord-336256-d5292aga 34 3 did do VBD cord-336256-d5292aga 34 4 not not RB cord-336256-d5292aga 34 5 retain retain VB cord-336256-d5292aga 34 6 significance significance NN cord-336256-d5292aga 34 7 after after IN cord-336256-d5292aga 34 8 multiple multiple JJ cord-336256-d5292aga 34 9 testing testing NN cord-336256-d5292aga 34 10 correction correction NN cord-336256-d5292aga 34 11 , , , cord-336256-d5292aga 34 12 there there EX cord-336256-d5292aga 34 13 is be VBZ cord-336256-d5292aga 34 14 possible possible JJ cord-336256-d5292aga 34 15 biological biological JJ cord-336256-d5292aga 34 16 validity validity NN cord-336256-d5292aga 34 17 to to IN cord-336256-d5292aga 34 18 this this DT cord-336256-d5292aga 34 19 observation observation NN cord-336256-d5292aga 34 20 as as IN cord-336256-d5292aga 34 21 SELENOF SELENOF NNP cord-336256-d5292aga 34 22 has have VBZ cord-336256-d5292aga 34 23 been be VBN cord-336256-d5292aga 34 24 previously previously RB cord-336256-d5292aga 34 25 linked link VBN cord-336256-d5292aga 34 26 with with IN cord-336256-d5292aga 34 27 oncogenesis oncogenesis NNP cord-336256-d5292aga 34 28 [ [ -LRB- cord-336256-d5292aga 34 29 6 6 CD cord-336256-d5292aga 34 30 ] ] -RRB- cord-336256-d5292aga 34 31 . . . cord-336256-d5292aga 35 1 Moving move VBG cord-336256-d5292aga 35 2 to to IN cord-336256-d5292aga 35 3 innovative innovative JJ cord-336256-d5292aga 35 4 Se Se NNP cord-336256-d5292aga 35 5 metabolism metabolism NN cord-336256-d5292aga 35 6 cell cell NN cord-336256-d5292aga 35 7 - - HYPH cord-336256-d5292aga 35 8 line line NN cord-336256-d5292aga 35 9 experiments experiment NNS cord-336256-d5292aga 35 10 , , , cord-336256-d5292aga 35 11 Sonet Sonet NNP cord-336256-d5292aga 35 12 et et FW cord-336256-d5292aga 35 13 al al NNP cord-336256-d5292aga 35 14 . . . cord-336256-d5292aga 36 1 suggest suggest VBP cord-336256-d5292aga 36 2 that that IN cord-336256-d5292aga 36 3 selenized selenized JJ cord-336256-d5292aga 36 4 lipids lipid NNS cord-336256-d5292aga 36 5 from from IN cord-336256-d5292aga 36 6 plant plant NN cord-336256-d5292aga 36 7 oils oil NNS cord-336256-d5292aga 36 8 ( ( -LRB- cord-336256-d5292aga 36 9 selenitriglycerides selenitriglyceride NNS cord-336256-d5292aga 36 10 ; ; : cord-336256-d5292aga 36 11 Selol Selol NNP cord-336256-d5292aga 36 12 ) ) -RRB- cord-336256-d5292aga 36 13 , , , cord-336256-d5292aga 36 14 proposed propose VBD cord-336256-d5292aga 36 15 to to TO cord-336256-d5292aga 36 16 have have VB cord-336256-d5292aga 36 17 antineoplastic antineoplastic JJ cord-336256-d5292aga 36 18 effects effect NNS cord-336256-d5292aga 36 19 , , , cord-336256-d5292aga 36 20 may may MD cord-336256-d5292aga 36 21 provide provide VB cord-336256-d5292aga 36 22 natural natural JJ cord-336256-d5292aga 36 23 Se Se NNP cord-336256-d5292aga 36 24 supplementation supplementation NN cord-336256-d5292aga 36 25 as as IN cord-336256-d5292aga 36 26 a a DT cord-336256-d5292aga 36 27 bioavailable bioavailable JJ cord-336256-d5292aga 36 28 selenocompound selenocompound NN cord-336256-d5292aga 36 29 with with IN cord-336256-d5292aga 36 30 lower low JJR cord-336256-d5292aga 36 31 toxicity toxicity NN cord-336256-d5292aga 36 32 than than IN cord-336256-d5292aga 36 33 chemical chemical JJ cord-336256-d5292aga 36 34 forms form NNS cord-336256-d5292aga 36 35 like like IN cord-336256-d5292aga 36 36 selenite selenite NN cord-336256-d5292aga 36 37 [ [ -LRB- cord-336256-d5292aga 36 38 8 8 CD cord-336256-d5292aga 36 39 ] ] -RRB- cord-336256-d5292aga 36 40 . . . cord-336256-d5292aga 37 1 The the DT cord-336256-d5292aga 37 2 authors author NNS cord-336256-d5292aga 37 3 showed show VBD cord-336256-d5292aga 37 4 that that IN cord-336256-d5292aga 37 5 Selol Selol NNP cord-336256-d5292aga 37 6 could could MD cord-336256-d5292aga 37 7 be be VB cord-336256-d5292aga 37 8 an an DT cord-336256-d5292aga 37 9 efficient efficient JJ cord-336256-d5292aga 37 10 source source NN cord-336256-d5292aga 37 11 of of IN cord-336256-d5292aga 37 12 Se Se NNP cord-336256-d5292aga 37 13 for for IN cord-336256-d5292aga 37 14 selenoprotein selenoprotein NNP cord-336256-d5292aga 37 15 biosynthesis biosynthesis NNP cord-336256-d5292aga 37 16 in in IN cord-336256-d5292aga 37 17 immortalized immortalize VBN cord-336256-d5292aga 37 18 kidney kidney NN cord-336256-d5292aga 37 19 ( ( -LRB- cord-336256-d5292aga 37 20 HEK293 HEK293 NNP cord-336256-d5292aga 37 21 ) ) -RRB- cord-336256-d5292aga 37 22 and and CC cord-336256-d5292aga 37 23 prostate prostate NN cord-336256-d5292aga 37 24 cancer cancer NN cord-336256-d5292aga 37 25 ( ( -LRB- cord-336256-d5292aga 37 26 LNCaP lncap NN cord-336256-d5292aga 37 27 ) ) -RRB- cord-336256-d5292aga 37 28 cell cell NN cord-336256-d5292aga 37 29 lines line NNS cord-336256-d5292aga 37 30 but but CC cord-336256-d5292aga 37 31 not not RB cord-336256-d5292aga 37 32 in in IN cord-336256-d5292aga 37 33 immortalized immortalize VBN cord-336256-d5292aga 37 34 prostate prostate NN cord-336256-d5292aga 37 35 cells cell NNS cord-336256-d5292aga 37 36 ( ( -LRB- cord-336256-d5292aga 37 37 PNT1A pnt1a NN cord-336256-d5292aga 37 38 , , , cord-336256-d5292aga 37 39 ) ) -RRB- cord-336256-d5292aga 37 40 possibly possibly RB cord-336256-d5292aga 37 41 due due JJ cord-336256-d5292aga 37 42 to to IN cord-336256-d5292aga 37 43 variance variance NN cord-336256-d5292aga 37 44 in in IN cord-336256-d5292aga 37 45 lipid lipid NN cord-336256-d5292aga 37 46 metabolism metabolism NN cord-336256-d5292aga 37 47 between between IN cord-336256-d5292aga 37 48 the the DT cord-336256-d5292aga 37 49 different different JJ cord-336256-d5292aga 37 50 cell cell NN cord-336256-d5292aga 37 51 lines line NNS cord-336256-d5292aga 37 52 [ [ -LRB- cord-336256-d5292aga 37 53 8 8 CD cord-336256-d5292aga 37 54 ] ] -RRB- cord-336256-d5292aga 37 55 . . . cord-336256-d5292aga 38 1 As as IN cord-336256-d5292aga 38 2 transformation transformation NN cord-336256-d5292aga 38 3 of of IN cord-336256-d5292aga 38 4 various various JJ cord-336256-d5292aga 38 5 chemical chemical NN cord-336256-d5292aga 38 6 species specie NNS cord-336256-d5292aga 38 7 into into IN cord-336256-d5292aga 38 8 selenide selenide NN cord-336256-d5292aga 38 9 is be VBZ cord-336256-d5292aga 38 10 the the DT cord-336256-d5292aga 38 11 gateway gateway NN cord-336256-d5292aga 38 12 step step NN cord-336256-d5292aga 38 13 for for IN cord-336256-d5292aga 38 14 further further JJ cord-336256-d5292aga 38 15 incorporation incorporation NN cord-336256-d5292aga 38 16 into into IN cord-336256-d5292aga 38 17 selenoproteins selenoprotein NNS cord-336256-d5292aga 38 18 , , , cord-336256-d5292aga 38 19 cell cell NN cord-336256-d5292aga 38 20 - - HYPH cord-336256-d5292aga 38 21 specific specific JJ cord-336256-d5292aga 38 22 Se Se NNP cord-336256-d5292aga 38 23 metabolism metabolism NN cord-336256-d5292aga 38 24 to to IN cord-336256-d5292aga 38 25 selenide selenide NN cord-336256-d5292aga 38 26 via via IN cord-336256-d5292aga 38 27 selenized selenized JJ cord-336256-d5292aga 38 28 triglycerides triglyceride NNS cord-336256-d5292aga 38 29 requires require VBZ cord-336256-d5292aga 38 30 further further JJ cord-336256-d5292aga 38 31 study study NN cord-336256-d5292aga 38 32 . . . cord-336256-d5292aga 39 1 The the DT cord-336256-d5292aga 39 2 importance importance NN cord-336256-d5292aga 39 3 of of IN cord-336256-d5292aga 39 4 Se Se NNP cord-336256-d5292aga 39 5 status status NN cord-336256-d5292aga 39 6 in in IN cord-336256-d5292aga 39 7 modifying modify VBG cord-336256-d5292aga 39 8 the the DT cord-336256-d5292aga 39 9 ability ability NN cord-336256-d5292aga 39 10 of of IN cord-336256-d5292aga 39 11 an an DT cord-336256-d5292aga 39 12 individual individual NN cord-336256-d5292aga 39 13 to to TO cord-336256-d5292aga 39 14 respond respond VB cord-336256-d5292aga 39 15 to to IN cord-336256-d5292aga 39 16 stress stress NN cord-336256-d5292aga 39 17 has have VBZ cord-336256-d5292aga 39 18 been be VBN cord-336256-d5292aga 39 19 linked link VBN cord-336256-d5292aga 39 20 to to IN cord-336256-d5292aga 39 21 the the DT cord-336256-d5292aga 39 22 development development NN cord-336256-d5292aga 39 23 of of IN cord-336256-d5292aga 39 24 many many JJ cord-336256-d5292aga 39 25 diseases disease NNS cord-336256-d5292aga 39 26 including include VBG cord-336256-d5292aga 39 27 CVD CVD NNP cord-336256-d5292aga 39 28 [ [ -LRB- cord-336256-d5292aga 39 29 1 1 CD cord-336256-d5292aga 39 30 , , , cord-336256-d5292aga 39 31 2 2 CD cord-336256-d5292aga 39 32 ] ] -RRB- cord-336256-d5292aga 39 33 , , , cord-336256-d5292aga 39 34 cancers cancer NNS cord-336256-d5292aga 39 35 [ [ -LRB- cord-336256-d5292aga 39 36 3 3 CD cord-336256-d5292aga 39 37 , , , cord-336256-d5292aga 39 38 6 6 CD cord-336256-d5292aga 39 39 ] ] -RRB- cord-336256-d5292aga 39 40 , , , cord-336256-d5292aga 39 41 and and CC cord-336256-d5292aga 39 42 neurodegeneration neurodegeneration NN cord-336256-d5292aga 39 43 [ [ -LRB- cord-336256-d5292aga 39 44 9 9 CD cord-336256-d5292aga 39 45 ] ] -RRB- cord-336256-d5292aga 39 46 . . . cord-336256-d5292aga 40 1 As as IN cord-336256-d5292aga 40 2 a a DT cord-336256-d5292aga 40 3 number number NN cord-336256-d5292aga 40 4 of of IN cord-336256-d5292aga 40 5 selenoproteins selenoprotein NNS cord-336256-d5292aga 40 6 play play VBP cord-336256-d5292aga 40 7 a a DT cord-336256-d5292aga 40 8 crucial crucial JJ cord-336256-d5292aga 40 9 prevalent prevalent JJ cord-336256-d5292aga 40 10 role role NN cord-336256-d5292aga 40 11 in in IN cord-336256-d5292aga 40 12 the the DT cord-336256-d5292aga 40 13 response response NN cord-336256-d5292aga 40 14 to to IN cord-336256-d5292aga 40 15 oxidative oxidative JJ cord-336256-d5292aga 40 16 stress stress NN cord-336256-d5292aga 40 17 and and CC cord-336256-d5292aga 40 18 the the DT cord-336256-d5292aga 40 19 control control NN cord-336256-d5292aga 40 20 of of IN cord-336256-d5292aga 40 21 redox redox JJ cord-336256-d5292aga 40 22 status status NN cord-336256-d5292aga 40 23 [ [ -LRB- cord-336256-d5292aga 40 24 3 3 CD cord-336256-d5292aga 40 25 , , , cord-336256-d5292aga 40 26 10 10 CD cord-336256-d5292aga 40 27 ] ] -RRB- cord-336256-d5292aga 40 28 as as RB cord-336256-d5292aga 40 29 well well RB cord-336256-d5292aga 40 30 as as IN cord-336256-d5292aga 40 31 in in IN cord-336256-d5292aga 40 32 the the DT cord-336256-d5292aga 40 33 maintenance maintenance NN cord-336256-d5292aga 40 34 of of IN cord-336256-d5292aga 40 35 endoplasmic endoplasmic NN cord-336256-d5292aga 40 36 reticulum reticulum NN cord-336256-d5292aga 40 37 ( ( -LRB- cord-336256-d5292aga 40 38 ER ER NNP cord-336256-d5292aga 40 39 ) ) -RRB- cord-336256-d5292aga 40 40 stress stress NN cord-336256-d5292aga 40 41 response response NN cord-336256-d5292aga 40 42 [ [ -LRB- cord-336256-d5292aga 40 43 9 9 CD cord-336256-d5292aga 40 44 ] ] -RRB- cord-336256-d5292aga 40 45 , , , cord-336256-d5292aga 40 46 mechanisms mechanism NNS cord-336256-d5292aga 40 47 that that WDT cord-336256-d5292aga 40 48 alter alter VBP cord-336256-d5292aga 40 49 the the DT cord-336256-d5292aga 40 50 expression expression NN cord-336256-d5292aga 40 51 of of IN cord-336256-d5292aga 40 52 these these DT cord-336256-d5292aga 40 53 selenoproteins selenoprotein NNS cord-336256-d5292aga 40 54 have have VBP cord-336256-d5292aga 40 55 the the DT cord-336256-d5292aga 40 56 potential potential NN cord-336256-d5292aga 40 57 to to TO cord-336256-d5292aga 40 58 lead lead VB cord-336256-d5292aga 40 59 to to IN cord-336256-d5292aga 40 60 an an DT cord-336256-d5292aga 40 61 increased increase VBN cord-336256-d5292aga 40 62 risk risk NN cord-336256-d5292aga 40 63 of of IN cord-336256-d5292aga 40 64 disease disease NN cord-336256-d5292aga 40 65 . . . cord-336256-d5292aga 41 1 In in IN cord-336256-d5292aga 41 2 a a DT cord-336256-d5292aga 41 3 currently currently RB cord-336256-d5292aga 41 4 highly highly RB cord-336256-d5292aga 41 5 pertinent pertinent JJ cord-336256-d5292aga 41 6 review review NN cord-336256-d5292aga 41 7 , , , cord-336256-d5292aga 41 8 considering consider VBG cord-336256-d5292aga 41 9 the the DT cord-336256-d5292aga 41 10 current current JJ cord-336256-d5292aga 41 11 pandemic pandemic NN cord-336256-d5292aga 41 12 of of IN cord-336256-d5292aga 41 13 the the DT cord-336256-d5292aga 41 14 SARS SARS NNP cord-336256-d5292aga 41 15 - - HYPH cord-336256-d5292aga 41 16 CoV-2 CoV-2 NNP cord-336256-d5292aga 41 17 virus virus NN cord-336256-d5292aga 41 18 mediated mediate VBD cord-336256-d5292aga 41 19 COVID-19 covid-19 JJ cord-336256-d5292aga 41 20 disease disease NN cord-336256-d5292aga 41 21 as as IN cord-336256-d5292aga 41 22 we -PRON- PRP cord-336256-d5292aga 41 23 write write VBP cord-336256-d5292aga 41 24 , , , cord-336256-d5292aga 41 25 Guillin Guillin NNP cord-336256-d5292aga 41 26 et et NNP cord-336256-d5292aga 41 27 al al NNP cord-336256-d5292aga 41 28 . . . cord-336256-d5292aga 42 1 discuss discuss VB cord-336256-d5292aga 42 2 the the DT cord-336256-d5292aga 42 3 role role NN cord-336256-d5292aga 42 4 of of IN cord-336256-d5292aga 42 5 Se Se NNP cord-336256-d5292aga 42 6 in in IN cord-336256-d5292aga 42 7 protection protection NN cord-336256-d5292aga 42 8 from from IN cord-336256-d5292aga 42 9 viral viral JJ cord-336256-d5292aga 42 10 contagion contagion NN cord-336256-d5292aga 42 11 [ [ -LRB- cord-336256-d5292aga 42 12 10 10 CD cord-336256-d5292aga 42 13 ] ] -RRB- cord-336256-d5292aga 42 14 . . . cord-336256-d5292aga 43 1 During during IN cord-336256-d5292aga 43 2 viral viral JJ cord-336256-d5292aga 43 3 infection infection NN cord-336256-d5292aga 43 4 , , , cord-336256-d5292aga 43 5 the the DT cord-336256-d5292aga 43 6 pathogens pathogen NNS cord-336256-d5292aga 43 7 induce induce VBP cord-336256-d5292aga 43 8 oxidative oxidative JJ cord-336256-d5292aga 43 9 stress stress NN cord-336256-d5292aga 43 10 by by IN cord-336256-d5292aga 43 11 generating generate VBG cord-336256-d5292aga 43 12 reactive reactive JJ cord-336256-d5292aga 43 13 oxygen oxygen NN cord-336256-d5292aga 43 14 species specie NNS cord-336256-d5292aga 43 15 and and CC cord-336256-d5292aga 43 16 by by IN cord-336256-d5292aga 43 17 altering alter VBG cord-336256-d5292aga 43 18 the the DT cord-336256-d5292aga 43 19 cellular cellular JJ cord-336256-d5292aga 43 20 antioxidant antioxidant JJ cord-336256-d5292aga 43 21 defences defence NNS cord-336256-d5292aga 43 22 , , , cord-336256-d5292aga 43 23 including include VBG cord-336256-d5292aga 43 24 selenoproteins selenoprotein NNS cord-336256-d5292aga 43 25 such such JJ cord-336256-d5292aga 43 26 as as IN cord-336256-d5292aga 43 27 glutathione glutathione NN cord-336256-d5292aga 43 28 peroxidases peroxidase NNS cord-336256-d5292aga 43 29 ( ( -LRB- cord-336256-d5292aga 43 30 GPx GPx NNS cord-336256-d5292aga 43 31 ) ) -RRB- cord-336256-d5292aga 43 32 and and CC cord-336256-d5292aga 43 33 thioredoxin thioredoxin NNP cord-336256-d5292aga 43 34 reductases reductase NNS cord-336256-d5292aga 43 35 . . . cord-336256-d5292aga 44 1 Consequently consequently RB cord-336256-d5292aga 44 2 , , , cord-336256-d5292aga 44 3 the the DT cord-336256-d5292aga 44 4 host host NN cord-336256-d5292aga 44 5 's 's POS cord-336256-d5292aga 44 6 Se Se NNP cord-336256-d5292aga 44 7 requirements requirement NNS cord-336256-d5292aga 44 8 increase increase NN cord-336256-d5292aga 44 9 and and CC cord-336256-d5292aga 44 10 , , , cord-336256-d5292aga 44 11 in in IN cord-336256-d5292aga 44 12 hosts host NNS cord-336256-d5292aga 44 13 deficient deficient JJ cord-336256-d5292aga 44 14 in in IN cord-336256-d5292aga 44 15 Se Se NNP cord-336256-d5292aga 44 16 , , , cord-336256-d5292aga 44 17 the the DT cord-336256-d5292aga 44 18 oxidative oxidative JJ cord-336256-d5292aga 44 19 stress stress NN cord-336256-d5292aga 44 20 can can MD cord-336256-d5292aga 44 21 induce induce VB cord-336256-d5292aga 44 22 viral viral JJ cord-336256-d5292aga 44 23 genome genome NN cord-336256-d5292aga 44 24 mutations mutation NNS cord-336256-d5292aga 44 25 , , , cord-336256-d5292aga 44 26 leading lead VBG cord-336256-d5292aga 44 27 to to IN cord-336256-d5292aga 44 28 increased increase VBN cord-336256-d5292aga 44 29 microbial microbial JJ cord-336256-d5292aga 44 30 virulence virulence NN cord-336256-d5292aga 44 31 ( ( -LRB- cord-336256-d5292aga 44 32 e.g. e.g. RB cord-336256-d5292aga 44 33 , , , cord-336256-d5292aga 44 34 coxsackie coxsackie NN cord-336256-d5292aga 44 35 and and CC cord-336256-d5292aga 44 36 influenza influenza NN cord-336256-d5292aga 44 37 viruses virus NNS cord-336256-d5292aga 44 38 ) ) -RRB- cord-336256-d5292aga 44 39 . . . cord-336256-d5292aga 45 1 Other other JJ cord-336256-d5292aga 45 2 mechanisms mechanism NNS cord-336256-d5292aga 45 3 by by IN cord-336256-d5292aga 45 4 which which WDT cord-336256-d5292aga 45 5 the the DT cord-336256-d5292aga 45 6 host host NN cord-336256-d5292aga 45 7 's 's POS cord-336256-d5292aga 45 8 nutritional nutritional JJ cord-336256-d5292aga 45 9 status status NN cord-336256-d5292aga 45 10 can can MD cord-336256-d5292aga 45 11 affect affect VB cord-336256-d5292aga 45 12 viral viral JJ cord-336256-d5292aga 45 13 infection infection NN cord-336256-d5292aga 45 14 progression progression NN cord-336256-d5292aga 45 15 include include VBP cord-336256-d5292aga 45 16 reducing reduce VBG cord-336256-d5292aga 45 17 the the DT cord-336256-d5292aga 45 18 ability ability NN cord-336256-d5292aga 45 19 of of IN cord-336256-d5292aga 45 20 the the DT cord-336256-d5292aga 45 21 immune immune JJ cord-336256-d5292aga 45 22 system system NN cord-336256-d5292aga 45 23 to to TO cord-336256-d5292aga 45 24 respond respond VB cord-336256-d5292aga 45 25 to to IN cord-336256-d5292aga 45 26 the the DT cord-336256-d5292aga 45 27 virus virus NN cord-336256-d5292aga 45 28 ( ( -LRB- cord-336256-d5292aga 45 29 e.g. e.g. RB cord-336256-d5292aga 45 30 , , , cord-336256-d5292aga 45 31 human human JJ cord-336256-d5292aga 45 32 immunodeficiency immunodeficiency NN cord-336256-d5292aga 45 33 virus virus NN cord-336256-d5292aga 45 34 ( ( -LRB- cord-336256-d5292aga 45 35 HIV HIV NNP cord-336256-d5292aga 45 36 ) ) -RRB- cord-336256-d5292aga 45 37 and and CC cord-336256-d5292aga 45 38 hepatitis hepatitis NNP cord-336256-d5292aga 45 39 C C NNP cord-336256-d5292aga 45 40 and and CC cord-336256-d5292aga 45 41 B b NN cord-336256-d5292aga 45 42 viruses virus NNS cord-336256-d5292aga 45 43 ) ) -RRB- cord-336256-d5292aga 45 44 . . . cord-336256-d5292aga 46 1 In in IN cord-336256-d5292aga 46 2 silico silico NN cord-336256-d5292aga 46 3 data datum NNS cord-336256-d5292aga 46 4 have have VBP cord-336256-d5292aga 46 5 also also RB cord-336256-d5292aga 46 6 revealed reveal VBN cord-336256-d5292aga 46 7 the the DT cord-336256-d5292aga 46 8 presence presence NN cord-336256-d5292aga 46 9 of of IN cord-336256-d5292aga 46 10 selenoprotein selenoprotein NNP cord-336256-d5292aga 46 11 genes gene NNS cord-336256-d5292aga 46 12 in in IN cord-336256-d5292aga 46 13 the the DT cord-336256-d5292aga 46 14 genomes genome NNS cord-336256-d5292aga 46 15 of of IN cord-336256-d5292aga 46 16 several several JJ cord-336256-d5292aga 46 17 common common JJ cord-336256-d5292aga 46 18 viruses virus NNS cord-336256-d5292aga 46 19 ( ( -LRB- cord-336256-d5292aga 46 20 e.g. e.g. RB cord-336256-d5292aga 46 21 , , , cord-336256-d5292aga 46 22 HIV HIV NNP cord-336256-d5292aga 46 23 ) ) -RRB- cord-336256-d5292aga 46 24 that that WDT cord-336256-d5292aga 46 25 resemble resemble VBP cord-336256-d5292aga 46 26 mammalian mammalian JJ cord-336256-d5292aga 46 27 GPx GPx NNS cord-336256-d5292aga 46 28 . . . cord-336256-d5292aga 47 1 The the DT cord-336256-d5292aga 47 2 function function NN cord-336256-d5292aga 47 3 and and CC cord-336256-d5292aga 47 4 regulation regulation NN cord-336256-d5292aga 47 5 of of IN cord-336256-d5292aga 47 6 such such JJ cord-336256-d5292aga 47 7 viral viral JJ cord-336256-d5292aga 47 8 selenoproteins selenoprotein NNS cord-336256-d5292aga 47 9 remains remain VBZ cord-336256-d5292aga 47 10 unclear unclear JJ cord-336256-d5292aga 47 11 but but CC cord-336256-d5292aga 47 12 could could MD cord-336256-d5292aga 47 13 afford afford VB cord-336256-d5292aga 47 14 viruses virus NNS cord-336256-d5292aga 47 15 protection protection NN cord-336256-d5292aga 47 16 from from IN cord-336256-d5292aga 47 17 oxidative oxidative JJ cord-336256-d5292aga 47 18 damage damage NN cord-336256-d5292aga 47 19 [ [ -LRB- cord-336256-d5292aga 47 20 10 10 CD cord-336256-d5292aga 47 21 ] ] -RRB- cord-336256-d5292aga 47 22 . . . cord-336256-d5292aga 48 1 Due due IN cord-336256-d5292aga 48 2 to to IN cord-336256-d5292aga 48 3 the the DT cord-336256-d5292aga 48 4 crucial crucial JJ cord-336256-d5292aga 48 5 role role NN cord-336256-d5292aga 48 6 of of IN cord-336256-d5292aga 48 7 ER ER NNP cord-336256-d5292aga 48 8 stress stress NN cord-336256-d5292aga 48 9 in in IN cord-336256-d5292aga 48 10 many many JJ cord-336256-d5292aga 48 11 cellular cellular JJ cord-336256-d5292aga 48 12 processes process NNS cord-336256-d5292aga 48 13 , , , cord-336256-d5292aga 48 14 understanding understand VBG cord-336256-d5292aga 48 15 the the DT cord-336256-d5292aga 48 16 consequences consequence NNS cord-336256-d5292aga 48 17 of of IN cord-336256-d5292aga 48 18 alteration alteration NN cord-336256-d5292aga 48 19 of of IN cord-336256-d5292aga 48 20 components component NNS cord-336256-d5292aga 48 21 of of IN cord-336256-d5292aga 48 22 the the DT cord-336256-d5292aga 48 23 ER ER NNP cord-336256-d5292aga 48 24 stress stress NN cord-336256-d5292aga 48 25 response response NN cord-336256-d5292aga 48 26 has have VBZ cord-336256-d5292aga 48 27 the the DT cord-336256-d5292aga 48 28 potential potential NN cord-336256-d5292aga 48 29 to to TO cord-336256-d5292aga 48 30 lead lead VB cord-336256-d5292aga 48 31 to to IN cord-336256-d5292aga 48 32 the the DT cord-336256-d5292aga 48 33 discovery discovery NN cord-336256-d5292aga 48 34 of of IN cord-336256-d5292aga 48 35 new new JJ cord-336256-d5292aga 48 36 therapeutic therapeutic JJ cord-336256-d5292aga 48 37 / / SYM cord-336256-d5292aga 48 38 nutritional nutritional JJ cord-336256-d5292aga 48 39 targets target NNS cord-336256-d5292aga 48 40 . . . cord-336256-d5292aga 49 1 Seven seven CD cord-336256-d5292aga 49 2 selenoproteins selenoprotein NNS cord-336256-d5292aga 49 3 are be VBP cord-336256-d5292aga 49 4 known know VBN cord-336256-d5292aga 49 5 to to TO cord-336256-d5292aga 49 6 be be VB cord-336256-d5292aga 49 7 present present JJ cord-336256-d5292aga 49 8 in in IN cord-336256-d5292aga 49 9 the the DT cord-336256-d5292aga 49 10 ER er NN cord-336256-d5292aga 49 11 , , , cord-336256-d5292aga 49 12 but but CC cord-336256-d5292aga 49 13 not not RB cord-336256-d5292aga 49 14 all all DT cord-336256-d5292aga 49 15 have have VBP cord-336256-d5292aga 49 16 been be VBN cord-336256-d5292aga 49 17 well well RB cord-336256-d5292aga 49 18 characterised characterise VBN cord-336256-d5292aga 49 19 . . . cord-336256-d5292aga 50 1 In in IN cord-336256-d5292aga 50 2 a a DT cord-336256-d5292aga 50 3 timely timely JJ cord-336256-d5292aga 50 4 review review NN cord-336256-d5292aga 50 5 , , , cord-336256-d5292aga 50 6 Ren Ren NNP cord-336256-d5292aga 50 7 et et NNP cord-336256-d5292aga 50 8 al al NNP cord-336256-d5292aga 50 9 . . . cord-336256-d5292aga 51 1 discuss discuss VB cord-336256-d5292aga 51 2 the the DT cord-336256-d5292aga 51 3 current current JJ cord-336256-d5292aga 51 4 knowledge knowledge NN cord-336256-d5292aga 51 5 on on IN cord-336256-d5292aga 51 6 ER er NN cord-336256-d5292aga 51 7 - - HYPH cord-336256-d5292aga 51 8 resident resident NN cord-336256-d5292aga 51 9 SELENOF SELENOF NNP cord-336256-d5292aga 51 10 , , , cord-336256-d5292aga 51 11 including include VBG cord-336256-d5292aga 51 12 its -PRON- PRP$ cord-336256-d5292aga 51 13 function function NN cord-336256-d5292aga 51 14 and and CC cord-336256-d5292aga 51 15 role role NN cord-336256-d5292aga 51 16 in in IN cord-336256-d5292aga 51 17 ER ER NNP cord-336256-d5292aga 51 18 stress stress NN cord-336256-d5292aga 51 19 response response NN cord-336256-d5292aga 51 20 and and CC cord-336256-d5292aga 51 21 the the DT cord-336256-d5292aga 51 22 regulation regulation NN cord-336256-d5292aga 51 23 of of IN cord-336256-d5292aga 51 24 its -PRON- PRP$ cord-336256-d5292aga 51 25 expression expression NN cord-336256-d5292aga 51 26 [ [ -LRB- cord-336256-d5292aga 51 27 9 9 CD cord-336256-d5292aga 51 28 ] ] -RRB- cord-336256-d5292aga 51 29 . . . cord-336256-d5292aga 52 1 The the DT cord-336256-d5292aga 52 2 review review NN cord-336256-d5292aga 52 3 also also RB cord-336256-d5292aga 52 4 summarises summarise VBZ cord-336256-d5292aga 52 5 results result NNS cord-336256-d5292aga 52 6 from from IN cord-336256-d5292aga 52 7 genetic genetic JJ cord-336256-d5292aga 52 8 association association NN cord-336256-d5292aga 52 9 studies study NNS cord-336256-d5292aga 52 10 linking link VBG cord-336256-d5292aga 52 11 genotypes genotype NNS cord-336256-d5292aga 52 12 for for IN cord-336256-d5292aga 52 13 SNPs snp NNS cord-336256-d5292aga 52 14 in in IN cord-336256-d5292aga 52 15 the the DT cord-336256-d5292aga 52 16 SELENOF SELENOF NNP cord-336256-d5292aga 52 17 gene gene NN cord-336256-d5292aga 52 18 to to TO cord-336256-d5292aga 52 19 risk risk NN cord-336256-d5292aga 52 20 for for IN cord-336256-d5292aga 52 21 various various JJ cord-336256-d5292aga 52 22 cancers cancer NNS cord-336256-d5292aga 52 23 , , , cord-336256-d5292aga 52 24 Kashin Kashin NNP cord-336256-d5292aga 52 25 - - HYPH cord-336256-d5292aga 52 26 Beck Beck NNP cord-336256-d5292aga 52 27 disease disease NN cord-336256-d5292aga 52 28 , , , cord-336256-d5292aga 52 29 and and CC cord-336256-d5292aga 52 30 AIDs AIDs NNP cord-336256-d5292aga 52 31 progression progression NN cord-336256-d5292aga 52 32 , , , cord-336256-d5292aga 52 33 with with IN cord-336256-d5292aga 52 34 a a DT cord-336256-d5292aga 52 35 particular particular JJ cord-336256-d5292aga 52 36 focus focus NN cord-336256-d5292aga 52 37 on on IN cord-336256-d5292aga 52 38 two two CD cord-336256-d5292aga 52 39 well well RB cord-336256-d5292aga 52 40 - - HYPH cord-336256-d5292aga 52 41 characterised characterise VBN cord-336256-d5292aga 52 42 functional functional JJ cord-336256-d5292aga 52 43 SNPs snp NNS cord-336256-d5292aga 52 44 ( ( -LRB- cord-336256-d5292aga 52 45 rs5845 rs5845 NNP cord-336256-d5292aga 52 46 and and CC cord-336256-d5292aga 52 47 rs5859 rs5859 NNP cord-336256-d5292aga 52 48 ) ) -RRB- cord-336256-d5292aga 52 49 affecting affect VBG cord-336256-d5292aga 52 50 SELENOF SELENOF NNP cord-336256-d5292aga 52 51 protein protein NN cord-336256-d5292aga 52 52 expression expression NN cord-336256-d5292aga 52 53 . . . cord-336256-d5292aga 53 1 Furthermore furthermore RB cord-336256-d5292aga 53 2 , , , cord-336256-d5292aga 53 3 the the DT cord-336256-d5292aga 53 4 authors author NNS cord-336256-d5292aga 53 5 discuss discuss VBP cord-336256-d5292aga 53 6 the the DT cord-336256-d5292aga 53 7 dysregulation dysregulation NN cord-336256-d5292aga 53 8 of of IN cord-336256-d5292aga 53 9 SELENOF SELENOF NNP cord-336256-d5292aga 53 10 expression expression NN cord-336256-d5292aga 53 11 in in IN cord-336256-d5292aga 53 12 several several JJ cord-336256-d5292aga 53 13 tissue tissue NN cord-336256-d5292aga 53 14 and and CC cord-336256-d5292aga 53 15 pathologies pathology NNS cord-336256-d5292aga 53 16 , , , cord-336256-d5292aga 53 17 from from IN cord-336256-d5292aga 53 18 cancer cancer NN cord-336256-d5292aga 53 19 to to IN cord-336256-d5292aga 53 20 neurodegeneration neurodegeneration NN cord-336256-d5292aga 53 21 and and CC cord-336256-d5292aga 53 22 immune immune JJ cord-336256-d5292aga 53 23 system system NN cord-336256-d5292aga 53 24 diseases disease NNS cord-336256-d5292aga 53 25 [ [ -LRB- cord-336256-d5292aga 53 26 9 9 CD cord-336256-d5292aga 53 27 ] ] -RRB- cord-336256-d5292aga 53 28 . . . cord-336256-d5292aga 54 1 Future future JJ cord-336256-d5292aga 54 2 studies study NNS cord-336256-d5292aga 54 3 investigating investigate VBG cord-336256-d5292aga 54 4 the the DT cord-336256-d5292aga 54 5 role role NN cord-336256-d5292aga 54 6 of of IN cord-336256-d5292aga 54 7 other other JJ cord-336256-d5292aga 54 8 ER er NN cord-336256-d5292aga 54 9 - - HYPH cord-336256-d5292aga 54 10 resident resident JJ cord-336256-d5292aga 54 11 selenoproteins selenoprotein NNS cord-336256-d5292aga 54 12 could could MD cord-336256-d5292aga 54 13 lead lead VB cord-336256-d5292aga 54 14 to to IN cord-336256-d5292aga 54 15 a a DT cord-336256-d5292aga 54 16 better well JJR cord-336256-d5292aga 54 17 understanding understanding NN cord-336256-d5292aga 54 18 of of IN cord-336256-d5292aga 54 19 mechanisms mechanism NNS cord-336256-d5292aga 54 20 that that WDT cord-336256-d5292aga 54 21 contribute contribute VBP cord-336256-d5292aga 54 22 to to IN cord-336256-d5292aga 54 23 the the DT cord-336256-d5292aga 54 24 development development NN cord-336256-d5292aga 54 25 of of IN cord-336256-d5292aga 54 26 a a DT cord-336256-d5292aga 54 27 wide wide JJ cord-336256-d5292aga 54 28 range range NN cord-336256-d5292aga 54 29 of of IN cord-336256-d5292aga 54 30 common common JJ cord-336256-d5292aga 54 31 complex complex JJ cord-336256-d5292aga 54 32 diseases disease NNS cord-336256-d5292aga 54 33 . . . cord-336256-d5292aga 55 1 Overall overall RB cord-336256-d5292aga 55 2 , , , cord-336256-d5292aga 55 3 the the DT cord-336256-d5292aga 55 4 studies study NNS cord-336256-d5292aga 55 5 in in IN cord-336256-d5292aga 55 6 this this DT cord-336256-d5292aga 55 7 Special Special NNP cord-336256-d5292aga 55 8 Issue Issue NNP cord-336256-d5292aga 55 9 strengthen strengthen VB cord-336256-d5292aga 55 10 and and CC cord-336256-d5292aga 55 11 broaden broaden VB cord-336256-d5292aga 55 12 the the DT cord-336256-d5292aga 55 13 evidence evidence NN cord-336256-d5292aga 55 14 base base NN cord-336256-d5292aga 55 15 that that IN cord-336256-d5292aga 55 16 the the DT cord-336256-d5292aga 55 17 risk risk NN cord-336256-d5292aga 55 18 of of IN cord-336256-d5292aga 55 19 several several JJ cord-336256-d5292aga 55 20 chronic chronic JJ cord-336256-d5292aga 55 21 diseases disease NNS cord-336256-d5292aga 55 22 and and CC cord-336256-d5292aga 55 23 viral viral JJ cord-336256-d5292aga 55 24 infections infection NNS cord-336256-d5292aga 55 25 may may MD cord-336256-d5292aga 55 26 be be VB cord-336256-d5292aga 55 27 modified modify VBN cord-336256-d5292aga 55 28 by by IN cord-336256-d5292aga 55 29 Se Se NNP cord-336256-d5292aga 55 30 status status NN cord-336256-d5292aga 55 31 , , , cord-336256-d5292aga 55 32 genotype genotype NN cord-336256-d5292aga 55 33 , , , cord-336256-d5292aga 55 34 sex sex NN cord-336256-d5292aga 55 35 , , , cord-336256-d5292aga 55 36 and and CC cord-336256-d5292aga 55 37 gene gene NN cord-336256-d5292aga 55 38 variation variation NN cord-336256-d5292aga 55 39 interactions interaction NNS cord-336256-d5292aga 55 40 within within IN cord-336256-d5292aga 55 41 biological biological JJ cord-336256-d5292aga 55 42 pathways pathway NNS cord-336256-d5292aga 55 43 . . . cord-336256-d5292aga 56 1 Detailed detailed JJ cord-336256-d5292aga 56 2 investigation investigation NN cord-336256-d5292aga 56 3 of of IN cord-336256-d5292aga 56 4 Se Se NNP cord-336256-d5292aga 56 5 intake intake NN cord-336256-d5292aga 56 6 levels level NNS cord-336256-d5292aga 56 7 and and CC cord-336256-d5292aga 56 8 metabolism metabolism NN cord-336256-d5292aga 56 9 is be VBZ cord-336256-d5292aga 56 10 needed need VBN cord-336256-d5292aga 56 11 to to TO cord-336256-d5292aga 56 12 more more RBR cord-336256-d5292aga 56 13 fully fully RB cord-336256-d5292aga 56 14 elucidate elucidate VB cord-336256-d5292aga 56 15 the the DT cord-336256-d5292aga 56 16 relevance relevance NN cord-336256-d5292aga 56 17 for for IN cord-336256-d5292aga 56 18 disease disease NN cord-336256-d5292aga 56 19 etiopathogenesis etiopathogenesis NNP cord-336256-d5292aga 56 20 , , , cord-336256-d5292aga 56 21 especially especially RB cord-336256-d5292aga 56 22 for for IN cord-336256-d5292aga 56 23 populations population NNS cord-336256-d5292aga 56 24 with with IN cord-336256-d5292aga 56 25 diverse diverse JJ cord-336256-d5292aga 56 26 Se Se NNP cord-336256-d5292aga 56 27 status status NN cord-336256-d5292aga 56 28 levels level NNS cord-336256-d5292aga 56 29 and/or and/or CC cord-336256-d5292aga 56 30 individuals individual NNS cord-336256-d5292aga 56 31 with with IN cord-336256-d5292aga 56 32 potentially potentially RB cord-336256-d5292aga 56 33 at at IN cord-336256-d5292aga 56 34 - - HYPH cord-336256-d5292aga 56 35 risk risk NN cord-336256-d5292aga 56 36 disease disease NN cord-336256-d5292aga 56 37 or or CC cord-336256-d5292aga 56 38 protective protective JJ cord-336256-d5292aga 56 39 Se Se NNP cord-336256-d5292aga 56 40 pathway pathway NN cord-336256-d5292aga 56 41 genotypes genotype NNS cord-336256-d5292aga 56 42 . . . cord-336256-d5292aga 56 43 _SP cord-336256-d5292aga 57 1 The the DT cord-336256-d5292aga 57 2 authors author NNS cord-336256-d5292aga 57 3 declare declare VBP cord-336256-d5292aga 57 4 no no DT cord-336256-d5292aga 57 5 conflict conflict NN cord-336256-d5292aga 57 6 of of IN cord-336256-d5292aga 57 7 interest interest NN cord-336256-d5292aga 57 8 . . . cord-336256-d5292aga 58 1 Though though RB cord-336256-d5292aga 58 2 , , , cord-336256-d5292aga 58 3 combined combine VBN cord-336256-d5292aga 58 4 , , , cord-336256-d5292aga 58 5 they -PRON- PRP cord-336256-d5292aga 58 6 are be VBP cord-336256-d5292aga 58 7 co co NNS cord-336256-d5292aga 58 8 - - NNS cord-336256-d5292aga 58 9 authors author NNS cord-336256-d5292aga 58 10 on on IN cord-336256-d5292aga 58 11 two two CD cord-336256-d5292aga 58 12 of of IN cord-336256-d5292aga 58 13 the the DT cord-336256-d5292aga 58 14 papers paper NNS cord-336256-d5292aga 58 15 in in IN cord-336256-d5292aga 58 16 this this DT cord-336256-d5292aga 58 17 special special JJ cord-336256-d5292aga 58 18 review review NN cord-336256-d5292aga 58 19 [ [ -LRB- cord-336256-d5292aga 58 20 3 3 CD cord-336256-d5292aga 58 21 , , , cord-336256-d5292aga 58 22 6 6 CD cord-336256-d5292aga 58 23 ] ] -RRB- cord-336256-d5292aga 58 24 , , , cord-336256-d5292aga 58 25 all all DT cord-336256-d5292aga 58 26 submissions submission NNS cord-336256-d5292aga 58 27 were be VBD cord-336256-d5292aga 58 28 considered consider VBN cord-336256-d5292aga 58 29 impartially impartially RB cord-336256-d5292aga 58 30 in in IN cord-336256-d5292aga 58 31 this this DT cord-336256-d5292aga 58 32 editorial editorial JJ cord-336256-d5292aga 58 33 commentary commentary NN cord-336256-d5292aga 58 34 . . . cord-336256-d5292aga 59 1 Selenium selenium NN cord-336256-d5292aga 59 2 - - HYPH cord-336256-d5292aga 59 3 Binding bind VBG cord-336256-d5292aga 59 4 Protein Protein NNP cord-336256-d5292aga 59 5 1 1 CD cord-336256-d5292aga 59 6 Indicates indicate VBZ cord-336256-d5292aga 59 7 Myocardial Myocardial NNP cord-336256-d5292aga 59 8 Stress Stress NNP cord-336256-d5292aga 59 9 and and CC cord-336256-d5292aga 59 10 Risk risk NN cord-336256-d5292aga 59 11 for for IN cord-336256-d5292aga 59 12 Adverse adverse JJ cord-336256-d5292aga 59 13 Outcome outcome NN cord-336256-d5292aga 59 14 in in IN cord-336256-d5292aga 59 15 Cardiac Cardiac NNP cord-336256-d5292aga 59 16 Surgery Surgery NNP cord-336256-d5292aga 59 17 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 59 18 - - HYPH cord-336256-d5292aga 59 19 P P NNP cord-336256-d5292aga 59 20 Deficiency deficiency NN cord-336256-d5292aga 60 1 Predicts predict VBZ cord-336256-d5292aga 60 2 Cardiovascular Cardiovascular NNP cord-336256-d5292aga 60 3 Disease Disease NNP cord-336256-d5292aga 60 4 and and CC cord-336256-d5292aga 60 5 Death Death NNP cord-336256-d5292aga 60 6 Association Association NNP cord-336256-d5292aga 60 7 of of IN cord-336256-d5292aga 60 8 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 60 9 and and CC cord-336256-d5292aga 60 10 Selenium Selenium NNP cord-336256-d5292aga 60 11 Pathway Pathway NNP cord-336256-d5292aga 60 12 Genotypes Genotypes NNP cord-336256-d5292aga 60 13 with with IN cord-336256-d5292aga 60 14 Risk risk NN cord-336256-d5292aga 60 15 of of IN cord-336256-d5292aga 60 16 Colorectal Colorectal NNP cord-336256-d5292aga 60 17 Cancer Cancer NNP cord-336256-d5292aga 60 18 and and CC cord-336256-d5292aga 60 19 Interaction Interaction NNP cord-336256-d5292aga 60 20 with with IN cord-336256-d5292aga 60 21 Selenium Selenium NNP cord-336256-d5292aga 60 22 Status Status NNP cord-336256-d5292aga 60 23 Selenium Selenium NNP cord-336256-d5292aga 60 24 and and CC cord-336256-d5292aga 60 25 Health Health NNP cord-336256-d5292aga 60 26 : : : cord-336256-d5292aga 61 1 An an DT cord-336256-d5292aga 61 2 Update update NN cord-336256-d5292aga 61 3 on on IN cord-336256-d5292aga 61 4 the the DT cord-336256-d5292aga 61 5 Situation situation NN cord-336256-d5292aga 61 6 in in IN cord-336256-d5292aga 61 7 the the DT cord-336256-d5292aga 61 8 Middle Middle NNP cord-336256-d5292aga 61 9 East East NNP cord-336256-d5292aga 61 10 and and CC cord-336256-d5292aga 61 11 North North NNP cord-336256-d5292aga 61 12 Africa Africa NNP cord-336256-d5292aga 61 13 Gender Gender NNP cord-336256-d5292aga 61 14 Differences difference NNS cord-336256-d5292aga 61 15 with with IN cord-336256-d5292aga 61 16 Dose Dose NNP cord-336256-d5292aga 61 17 - - HYPH cord-336256-d5292aga 61 18 Response response NN cord-336256-d5292aga 61 19 Relationship relationship NN cord-336256-d5292aga 61 20 between between IN cord-336256-d5292aga 61 21 Serum Serum NNP cord-336256-d5292aga 61 22 Selenium Selenium NNP cord-336256-d5292aga 61 23 Levels Levels NNPS cord-336256-d5292aga 61 24 and and CC cord-336256-d5292aga 61 25 Metabolic Metabolic NNP cord-336256-d5292aga 61 26 Syndrome Syndrome NNP cord-336256-d5292aga 61 27 - - HYPH cord-336256-d5292aga 61 28 A A NNP cord-336256-d5292aga 61 29 Case Case NNP cord-336256-d5292aga 61 30 - - HYPH cord-336256-d5292aga 61 31 Control Control NNP cord-336256-d5292aga 61 32 Study Study NNP cord-336256-d5292aga 61 33 Expression expression NN cord-336256-d5292aga 61 34 of of IN cord-336256-d5292aga 61 35 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 61 36 Genes Genes NNP cord-336256-d5292aga 61 37 and and CC cord-336256-d5292aga 61 38 Association Association NNP cord-336256-d5292aga 61 39 with with IN cord-336256-d5292aga 61 40 Selenium Selenium NNP cord-336256-d5292aga 61 41 Status Status NNP cord-336256-d5292aga 61 42 in in IN cord-336256-d5292aga 61 43 Colorectal Colorectal NNP cord-336256-d5292aga 61 44 Adenoma Adenoma NNP cord-336256-d5292aga 61 45 and and CC cord-336256-d5292aga 61 46 Colorectal Colorectal NNP cord-336256-d5292aga 61 47 Cancer Cancer NNP cord-336256-d5292aga 61 48 Agrp Agrp NNP cord-336256-d5292aga 61 49 - - HYPH cord-336256-d5292aga 61 50 Specific specific JJ cord-336256-d5292aga 61 51 Ablation ablation NN cord-336256-d5292aga 61 52 of of IN cord-336256-d5292aga 61 53 Scly Scly NNP cord-336256-d5292aga 61 54 Protects protect VBZ cord-336256-d5292aga 61 55 against against IN cord-336256-d5292aga 61 56 Diet Diet NNP cord-336256-d5292aga 61 57 - - HYPH cord-336256-d5292aga 61 58 Induced Induced NNP cord-336256-d5292aga 61 59 Obesity Obesity NNP cord-336256-d5292aga 61 60 and and CC cord-336256-d5292aga 61 61 Leptin Leptin NNP cord-336256-d5292aga 61 62 Resistance Resistance NNP cord-336256-d5292aga 61 63 Selenized Selenized NNP cord-336256-d5292aga 61 64 Plant Plant NNP cord-336256-d5292aga 61 65 Oil Oil NNP cord-336256-d5292aga 61 66 Is be VBZ cord-336256-d5292aga 61 67 an an DT cord-336256-d5292aga 61 68 Efficient efficient JJ cord-336256-d5292aga 61 69 Source source NN cord-336256-d5292aga 61 70 of of IN cord-336256-d5292aga 61 71 Selenium Selenium NNP cord-336256-d5292aga 61 72 for for IN cord-336256-d5292aga 61 73 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 61 74 Biosynthesis Biosynthesis NNP cord-336256-d5292aga 61 75 in in IN cord-336256-d5292aga 61 76 Human Human NNP cord-336256-d5292aga 61 77 Cell Cell NNP cord-336256-d5292aga 61 78 Lines Lines NNP cord-336256-d5292aga 61 79 Role role NN cord-336256-d5292aga 61 80 of of IN cord-336256-d5292aga 61 81 Selenoprotein Selenoprotein NNP cord-336256-d5292aga 61 82 F F NNP cord-336256-d5292aga 61 83 in in IN cord-336256-d5292aga 61 84 Protein Protein NNP cord-336256-d5292aga 61 85 Folding Folding NNP cord-336256-d5292aga 61 86 and and CC cord-336256-d5292aga 61 87 Secretion secretion NN cord-336256-d5292aga 61 88 : : : cord-336256-d5292aga 62 1 Potential Potential NNP cord-336256-d5292aga 62 2 Involvement Involvement NNP cord-336256-d5292aga 62 3 in in IN cord-336256-d5292aga 62 4 Human Human NNP cord-336256-d5292aga 62 5 Disease Disease NNP cord-336256-d5292aga 62 6 Selenoproteins Selenoproteins NNPS cord-336256-d5292aga 62 7 and and CC cord-336256-d5292aga 62 8 Viral Viral NNP cord-336256-d5292aga 62 9 Infection infection NN cord-336256-d5292aga 63 1 This this DT cord-336256-d5292aga 63 2 article article NN cord-336256-d5292aga 63 3 is be VBZ cord-336256-d5292aga 63 4 an an DT cord-336256-d5292aga 63 5 open open JJ cord-336256-d5292aga 63 6 access access NN cord-336256-d5292aga 63 7 article article NN cord-336256-d5292aga 63 8 distributed distribute VBN cord-336256-d5292aga 63 9 under under IN cord-336256-d5292aga 63 10 the the DT cord-336256-d5292aga 63 11 terms term NNS cord-336256-d5292aga 63 12 and and CC cord-336256-d5292aga 63 13 conditions condition NNS cord-336256-d5292aga 63 14 of of IN cord-336256-d5292aga 63 15 the the DT cord-336256-d5292aga 63 16 Creative Creative NNP cord-336256-d5292aga 63 17 Commons Commons NNP cord-336256-d5292aga 63 18 Attribution Attribution NNP cord-336256-d5292aga 63 19 ( ( -LRB- cord-336256-d5292aga 63 20 CC CC NNP cord-336256-d5292aga 63 21 BY by IN cord-336256-d5292aga 63 22 ) ) -RRB- cord-336256-d5292aga 63 23 license license NN