id sid tid token lemma pos cord-337849-tyabf12r 1 1 key key NN cord-337849-tyabf12r 1 2 : : : cord-337849-tyabf12r 2 1 cord-337849-tyabf12r cord-337849-tyabf12r NNP cord-337849-tyabf12r 2 2 authors author NNS cord-337849-tyabf12r 2 3 : : : cord-337849-tyabf12r 2 4 Greiller Greiller NNP cord-337849-tyabf12r 2 5 , , , cord-337849-tyabf12r 2 6 Claire Claire NNP cord-337849-tyabf12r 2 7 L. L. NNP cord-337849-tyabf12r 2 8 ; ; : cord-337849-tyabf12r 2 9 Martineau Martineau NNP cord-337849-tyabf12r 2 10 , , , cord-337849-tyabf12r 2 11 Adrian Adrian NNP cord-337849-tyabf12r 2 12 R. R. NNP cord-337849-tyabf12r 2 13 title title NN cord-337849-tyabf12r 2 14 : : : cord-337849-tyabf12r 2 15 Modulation modulation NN cord-337849-tyabf12r 2 16 of of IN cord-337849-tyabf12r 2 17 the the DT cord-337849-tyabf12r 2 18 Immune Immune NNP cord-337849-tyabf12r 2 19 Response response NN cord-337849-tyabf12r 2 20 to to IN cord-337849-tyabf12r 2 21 Respiratory respiratory JJ cord-337849-tyabf12r 2 22 Viruses virus NNS cord-337849-tyabf12r 2 23 by by IN cord-337849-tyabf12r 2 24 Vitamin vitamin NN cord-337849-tyabf12r 2 25 D d NN cord-337849-tyabf12r 2 26 date date NN cord-337849-tyabf12r 2 27 : : : cord-337849-tyabf12r 2 28 2015 2015 CD cord-337849-tyabf12r 2 29 - - HYPH cord-337849-tyabf12r 2 30 05 05 CD cord-337849-tyabf12r 2 31 - - HYPH cord-337849-tyabf12r 2 32 29 29 CD cord-337849-tyabf12r 2 33 journal journal NN cord-337849-tyabf12r 2 34 : : : cord-337849-tyabf12r 3 1 Nutrients nutrient NNS cord-337849-tyabf12r 3 2 DOI DOI NNP cord-337849-tyabf12r 3 3 : : : cord-337849-tyabf12r 4 1 10.3390/ 10.3390/ CD cord-337849-tyabf12r 5 1 nu7064240 nu7064240 NNP cord-337849-tyabf12r 5 2 sha sha NNP cord-337849-tyabf12r 5 3 : : : cord-337849-tyabf12r 6 1 35f06fe8870be0c3cd7f0e9b47872a59c7590d7d 35f06fe8870be0c3cd7f0e9b47872a59c7590d7d NNP cord-337849-tyabf12r 6 2 doc_id doc_id CD cord-337849-tyabf12r 6 3 : : : cord-337849-tyabf12r 6 4 337849 337849 CD cord-337849-tyabf12r 6 5 cord_uid cord_uid NNS cord-337849-tyabf12r 6 6 : : : cord-337849-tyabf12r 6 7 tyabf12r tyabf12r . cord-337849-tyabf12r 7 1 Background background NN cord-337849-tyabf12r 7 2 : : : cord-337849-tyabf12r 8 1 Vitamin vitamin NN cord-337849-tyabf12r 8 2 D d NN cord-337849-tyabf12r 8 3 deficiency deficiency NN cord-337849-tyabf12r 8 4 has have VBZ cord-337849-tyabf12r 8 5 been be VBN cord-337849-tyabf12r 8 6 shown show VBN cord-337849-tyabf12r 8 7 to to TO cord-337849-tyabf12r 8 8 be be VB cord-337849-tyabf12r 8 9 independently independently RB cord-337849-tyabf12r 8 10 associated associate VBN cord-337849-tyabf12r 8 11 with with IN cord-337849-tyabf12r 8 12 increased increase VBN cord-337849-tyabf12r 8 13 risk risk NN cord-337849-tyabf12r 8 14 of of IN cord-337849-tyabf12r 8 15 viral viral JJ cord-337849-tyabf12r 8 16 acute acute JJ cord-337849-tyabf12r 8 17 respiratory respiratory JJ cord-337849-tyabf12r 8 18 infection infection NN cord-337849-tyabf12r 8 19 ( ( -LRB- cord-337849-tyabf12r 8 20 ARI ARI NNP cord-337849-tyabf12r 8 21 ) ) -RRB- cord-337849-tyabf12r 8 22 in in IN cord-337849-tyabf12r 8 23 a a DT cord-337849-tyabf12r 8 24 number number NN cord-337849-tyabf12r 8 25 of of IN cord-337849-tyabf12r 8 26 observational observational JJ cord-337849-tyabf12r 8 27 studies study NNS cord-337849-tyabf12r 8 28 , , , cord-337849-tyabf12r 8 29 and and CC cord-337849-tyabf12r 8 30 meta meta NNP cord-337849-tyabf12r 8 31 - - HYPH cord-337849-tyabf12r 8 32 analysis analysis NN cord-337849-tyabf12r 8 33 of of IN cord-337849-tyabf12r 8 34 clinical clinical JJ cord-337849-tyabf12r 8 35 trials trial NNS cord-337849-tyabf12r 8 36 of of IN cord-337849-tyabf12r 8 37 vitamin vitamin NN cord-337849-tyabf12r 8 38 D d NN cord-337849-tyabf12r 8 39 supplementation supplementation NN cord-337849-tyabf12r 8 40 for for IN cord-337849-tyabf12r 8 41 prevention prevention NN cord-337849-tyabf12r 8 42 of of IN cord-337849-tyabf12r 8 43 ARI ARI NNP cord-337849-tyabf12r 8 44 has have VBZ cord-337849-tyabf12r 8 45 demonstrated demonstrate VBN cord-337849-tyabf12r 8 46 protective protective JJ cord-337849-tyabf12r 8 47 effects effect NNS cord-337849-tyabf12r 8 48 . . . cord-337849-tyabf12r 9 1 Several several JJ cord-337849-tyabf12r 9 2 cellular cellular JJ cord-337849-tyabf12r 9 3 studies study NNS cord-337849-tyabf12r 9 4 have have VBP cord-337849-tyabf12r 9 5 investigated investigate VBN cord-337849-tyabf12r 9 6 the the DT cord-337849-tyabf12r 9 7 effects effect NNS cord-337849-tyabf12r 9 8 of of IN cord-337849-tyabf12r 9 9 vitamin vitamin NN cord-337849-tyabf12r 9 10 D d NN cord-337849-tyabf12r 9 11 metabolites metabolite NNS cord-337849-tyabf12r 9 12 on on IN cord-337849-tyabf12r 9 13 immune immune JJ cord-337849-tyabf12r 9 14 responses response NNS cord-337849-tyabf12r 9 15 to to IN cord-337849-tyabf12r 9 16 respiratory respiratory JJ cord-337849-tyabf12r 9 17 viruses virus NNS cord-337849-tyabf12r 9 18 , , , cord-337849-tyabf12r 9 19 but but CC cord-337849-tyabf12r 9 20 syntheses synthesis NNS cord-337849-tyabf12r 9 21 of of IN cord-337849-tyabf12r 9 22 these these DT cord-337849-tyabf12r 9 23 reports report NNS cord-337849-tyabf12r 9 24 are be VBP cord-337849-tyabf12r 9 25 lacking lack VBG cord-337849-tyabf12r 9 26 . . . cord-337849-tyabf12r 10 1 Scope scope NN cord-337849-tyabf12r 10 2 : : : cord-337849-tyabf12r 11 1 In in IN cord-337849-tyabf12r 11 2 this this DT cord-337849-tyabf12r 11 3 article article NN cord-337849-tyabf12r 11 4 , , , cord-337849-tyabf12r 11 5 we -PRON- PRP cord-337849-tyabf12r 11 6 review review VBP cord-337849-tyabf12r 11 7 the the DT cord-337849-tyabf12r 11 8 literature literature NN cord-337849-tyabf12r 11 9 reporting report VBG cord-337849-tyabf12r 11 10 results result NNS cord-337849-tyabf12r 11 11 of of IN cord-337849-tyabf12r 11 12 in in FW cord-337849-tyabf12r 11 13 vitro vitro FW cord-337849-tyabf12r 11 14 experiments experiment NNS cord-337849-tyabf12r 11 15 investigating investigate VBG cord-337849-tyabf12r 11 16 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 11 17 actions action NNS cord-337849-tyabf12r 11 18 of of IN cord-337849-tyabf12r 11 19 vitamin vitamin NN cord-337849-tyabf12r 11 20 D d NN cord-337849-tyabf12r 11 21 metabolites metabolite NNS cord-337849-tyabf12r 11 22 in in IN cord-337849-tyabf12r 11 23 human human JJ cord-337849-tyabf12r 11 24 respiratory respiratory JJ cord-337849-tyabf12r 11 25 epithelial epithelial JJ cord-337849-tyabf12r 11 26 cells cell NNS cord-337849-tyabf12r 11 27 infected infect VBN cord-337849-tyabf12r 11 28 with with IN cord-337849-tyabf12r 11 29 respiratory respiratory JJ cord-337849-tyabf12r 11 30 viruses virus NNS cord-337849-tyabf12r 11 31 . . . cord-337849-tyabf12r 12 1 Key key JJ cord-337849-tyabf12r 12 2 findings finding NNS cord-337849-tyabf12r 12 3 : : : cord-337849-tyabf12r 12 4 Vitamin vitamin NN cord-337849-tyabf12r 12 5 D d NN cord-337849-tyabf12r 12 6 metabolites metabolite NNS cord-337849-tyabf12r 12 7 do do VBP cord-337849-tyabf12r 12 8 not not RB cord-337849-tyabf12r 12 9 consistently consistently RB cord-337849-tyabf12r 12 10 influence influence VB cord-337849-tyabf12r 12 11 replication replication NN cord-337849-tyabf12r 12 12 or or CC cord-337849-tyabf12r 12 13 clearance clearance NN cord-337849-tyabf12r 12 14 of of IN cord-337849-tyabf12r 12 15 rhinovirus rhinovirus NN cord-337849-tyabf12r 12 16 , , , cord-337849-tyabf12r 12 17 respiratory respiratory JJ cord-337849-tyabf12r 12 18 syncytial syncytial JJ cord-337849-tyabf12r 12 19 virus virus NN cord-337849-tyabf12r 12 20 ( ( -LRB- cord-337849-tyabf12r 12 21 RSV RSV NNP cord-337849-tyabf12r 12 22 ) ) -RRB- cord-337849-tyabf12r 12 23 or or CC cord-337849-tyabf12r 12 24 influenza influenza NN cord-337849-tyabf12r 12 25 A a DT cord-337849-tyabf12r 12 26 virus virus NN cord-337849-tyabf12r 12 27 in in IN cord-337849-tyabf12r 12 28 human human JJ cord-337849-tyabf12r 12 29 respiratory respiratory JJ cord-337849-tyabf12r 12 30 epithelial epithelial JJ cord-337849-tyabf12r 12 31 cell cell NN cord-337849-tyabf12r 12 32 culture culture NN cord-337849-tyabf12r 12 33 , , , cord-337849-tyabf12r 12 34 although although IN cord-337849-tyabf12r 12 35 they -PRON- PRP cord-337849-tyabf12r 12 36 do do VBP cord-337849-tyabf12r 12 37 modulate modulate VB cord-337849-tyabf12r 12 38 expression expression NN cord-337849-tyabf12r 12 39 and and CC cord-337849-tyabf12r 12 40 secretion secretion NN cord-337849-tyabf12r 12 41 of of IN cord-337849-tyabf12r 12 42 type type NN cord-337849-tyabf12r 12 43 1 1 CD cord-337849-tyabf12r 12 44 interferon interferon NN cord-337849-tyabf12r 12 45 , , , cord-337849-tyabf12r 12 46 chemokines chemokine NNS cord-337849-tyabf12r 12 47 including include VBG cord-337849-tyabf12r 12 48 CXCL8 cxcl8 NN cord-337849-tyabf12r 12 49 and and CC cord-337849-tyabf12r 12 50 CXCL10 CXCL10 NNP cord-337849-tyabf12r 12 51 and and CC cord-337849-tyabf12r 12 52 pro pro JJ cord-337849-tyabf12r 12 53 - - JJ cord-337849-tyabf12r 12 54 inflammatory inflammatory JJ cord-337849-tyabf12r 12 55 cytokines cytokine NNS cord-337849-tyabf12r 12 56 , , , cord-337849-tyabf12r 12 57 such such JJ cord-337849-tyabf12r 12 58 as as IN cord-337849-tyabf12r 12 59 TNF TNF NNP cord-337849-tyabf12r 12 60 and and CC cord-337849-tyabf12r 12 61 IL-6 IL-6 NNP cord-337849-tyabf12r 12 62 . . . cord-337849-tyabf12r 13 1 Future future JJ cord-337849-tyabf12r 13 2 research research NN cord-337849-tyabf12r 13 3 : : : cord-337849-tyabf12r 14 1 More More JJR cord-337849-tyabf12r 14 2 studies study NNS cord-337849-tyabf12r 14 3 are be VBP cord-337849-tyabf12r 14 4 needed need VBN cord-337849-tyabf12r 14 5 to to TO cord-337849-tyabf12r 14 6 clarify clarify VB cord-337849-tyabf12r 14 7 the the DT cord-337849-tyabf12r 14 8 effects effect NNS cord-337849-tyabf12r 14 9 of of IN cord-337849-tyabf12r 14 10 vitamin vitamin NN cord-337849-tyabf12r 14 11 D d NN cord-337849-tyabf12r 14 12 metabolites metabolite NNS cord-337849-tyabf12r 14 13 on on IN cord-337849-tyabf12r 14 14 respiratory respiratory JJ cord-337849-tyabf12r 14 15 virus virus NN cord-337849-tyabf12r 14 16 - - HYPH cord-337849-tyabf12r 14 17 induced induce VBN cord-337849-tyabf12r 14 18 expression expression NN cord-337849-tyabf12r 14 19 of of IN cord-337849-tyabf12r 14 20 cell cell NN cord-337849-tyabf12r 14 21 surface surface NN cord-337849-tyabf12r 14 22 markers marker NNS cord-337849-tyabf12r 14 23 mediating mediate VBG cord-337849-tyabf12r 14 24 viral viral JJ cord-337849-tyabf12r 14 25 entry entry NN cord-337849-tyabf12r 14 26 and and CC cord-337849-tyabf12r 14 27 bacterial bacterial JJ cord-337849-tyabf12r 14 28 adhesion adhesion NN cord-337849-tyabf12r 14 29 to to IN cord-337849-tyabf12r 14 30 respiratory respiratory JJ cord-337849-tyabf12r 14 31 epithelial epithelial JJ cord-337849-tyabf12r 14 32 cells cell NNS cord-337849-tyabf12r 14 33 . . . cord-337849-tyabf12r 15 1 Viral viral JJ cord-337849-tyabf12r 15 2 acute acute JJ cord-337849-tyabf12r 15 3 respiratory respiratory JJ cord-337849-tyabf12r 15 4 infections infection NNS cord-337849-tyabf12r 15 5 ( ( -LRB- cord-337849-tyabf12r 15 6 ARI ARI NNP cord-337849-tyabf12r 15 7 ) ) -RRB- cord-337849-tyabf12r 15 8 are be VBP cord-337849-tyabf12r 15 9 a a DT cord-337849-tyabf12r 15 10 leading leading JJ cord-337849-tyabf12r 15 11 cause cause NN cord-337849-tyabf12r 15 12 of of IN cord-337849-tyabf12r 15 13 morbidity morbidity NN cord-337849-tyabf12r 15 14 and and CC cord-337849-tyabf12r 15 15 mortality mortality NN cord-337849-tyabf12r 15 16 worldwide worldwide RB cord-337849-tyabf12r 15 17 , , , cord-337849-tyabf12r 15 18 and and CC cord-337849-tyabf12r 15 19 , , , cord-337849-tyabf12r 15 20 as as IN cord-337849-tyabf12r 15 21 such such JJ cord-337849-tyabf12r 15 22 , , , cord-337849-tyabf12r 15 23 are be VBP cord-337849-tyabf12r 15 24 a a DT cord-337849-tyabf12r 15 25 major major JJ cord-337849-tyabf12r 15 26 global global JJ cord-337849-tyabf12r 15 27 health health NN cord-337849-tyabf12r 15 28 problem problem NN cord-337849-tyabf12r 15 29 . . . cord-337849-tyabf12r 16 1 They -PRON- PRP cord-337849-tyabf12r 16 2 are be VBP cord-337849-tyabf12r 16 3 also also RB cord-337849-tyabf12r 16 4 responsible responsible JJ cord-337849-tyabf12r 16 5 for for IN cord-337849-tyabf12r 16 6 a a DT cord-337849-tyabf12r 16 7 huge huge JJ cord-337849-tyabf12r 16 8 economic economic JJ cord-337849-tyabf12r 16 9 burden burden NN cord-337849-tyabf12r 16 10 , , , cord-337849-tyabf12r 16 11 precipitating precipitate VBG cord-337849-tyabf12r 16 12 considerable considerable JJ cord-337849-tyabf12r 16 13 absence absence NN cord-337849-tyabf12r 16 14 from from IN cord-337849-tyabf12r 16 15 work work NN cord-337849-tyabf12r 16 16 and and CC cord-337849-tyabf12r 16 17 school school NN cord-337849-tyabf12r 16 18 , , , cord-337849-tyabf12r 16 19 and and CC cord-337849-tyabf12r 16 20 large large JJ cord-337849-tyabf12r 16 21 numbers number NNS cord-337849-tyabf12r 16 22 of of IN cord-337849-tyabf12r 16 23 visits visit NNS cord-337849-tyabf12r 16 24 to to IN cord-337849-tyabf12r 16 25 clinicians clinician NNS cord-337849-tyabf12r 16 26 . . . cord-337849-tyabf12r 17 1 The the DT cord-337849-tyabf12r 17 2 viral viral JJ cord-337849-tyabf12r 17 3 pathogens pathogen NNS cord-337849-tyabf12r 17 4 most most RBS cord-337849-tyabf12r 17 5 commonly commonly RB cord-337849-tyabf12r 17 6 associated associate VBN cord-337849-tyabf12r 17 7 with with IN cord-337849-tyabf12r 17 8 acute acute JJ cord-337849-tyabf12r 17 9 respiratory respiratory JJ cord-337849-tyabf12r 17 10 infections infection NNS cord-337849-tyabf12r 17 11 are be VBP cord-337849-tyabf12r 17 12 picornaviruses picornavirus NNS cord-337849-tyabf12r 17 13 ( ( -LRB- cord-337849-tyabf12r 17 14 including include VBG cord-337849-tyabf12r 17 15 the the DT cord-337849-tyabf12r 17 16 species specie NNS cord-337849-tyabf12r 17 17 rhinovirus rhinovirus NN cord-337849-tyabf12r 17 18 ( ( -LRB- cord-337849-tyabf12r 17 19 RV rv NN cord-337849-tyabf12r 17 20 ) ) -RRB- cord-337849-tyabf12r 18 1 A a LS cord-337849-tyabf12r 18 2 , , , cord-337849-tyabf12r 18 3 RVB RVB NNP cord-337849-tyabf12r 18 4 , , , cord-337849-tyabf12r 18 5 RVC RVC NNP cord-337849-tyabf12r 18 6 and and CC cord-337849-tyabf12r 18 7 the the DT cord-337849-tyabf12r 18 8 enteroviruses enterovirus NNS cord-337849-tyabf12r 18 9 A A NNP cord-337849-tyabf12r 18 10 - - HYPH cord-337849-tyabf12r 18 11 D D NNP cord-337849-tyabf12r 18 12 ) ) -RRB- cord-337849-tyabf12r 18 13 , , , cord-337849-tyabf12r 18 14 orthomyxoviruses orthomyxoviruses NNP cord-337849-tyabf12r 18 15 ( ( -LRB- cord-337849-tyabf12r 18 16 influenza influenza NN cord-337849-tyabf12r 18 17 A A NNP cord-337849-tyabf12r 18 18 , , , cord-337849-tyabf12r 18 19 influenza influenza NN cord-337849-tyabf12r 18 20 B b NN cord-337849-tyabf12r 18 21 and and CC cord-337849-tyabf12r 18 22 influenza influenza NN cord-337849-tyabf12r 18 23 C C NNP cord-337849-tyabf12r 18 24 ) ) -RRB- cord-337849-tyabf12r 18 25 , , , cord-337849-tyabf12r 18 26 paramyxoviruses paramyxoviruses NNP cord-337849-tyabf12r 18 27 ( ( -LRB- cord-337849-tyabf12r 18 28 including include VBG cord-337849-tyabf12r 18 29 the the DT cord-337849-tyabf12r 18 30 parainfluenza parainfluenza NNP cord-337849-tyabf12r 18 31 viruses virus NNS cord-337849-tyabf12r 18 32 ( ( -LRB- cord-337849-tyabf12r 18 33 PIV PIV NNP cord-337849-tyabf12r 18 34 ) ) -RRB- cord-337849-tyabf12r 18 35 1 1 CD cord-337849-tyabf12r 18 36 - - SYM cord-337849-tyabf12r 18 37 4 4 CD cord-337849-tyabf12r 18 38 , , , cord-337849-tyabf12r 18 39 respiratory respiratory JJ cord-337849-tyabf12r 18 40 syncytial syncytial JJ cord-337849-tyabf12r 18 41 virus virus NN cord-337849-tyabf12r 18 42 ( ( -LRB- cord-337849-tyabf12r 18 43 RSV RSV NNP cord-337849-tyabf12r 18 44 ) ) -RRB- cord-337849-tyabf12r 18 45 and and CC cord-337849-tyabf12r 18 46 human human JJ cord-337849-tyabf12r 18 47 metapneumovirus metapneumovirus NNP cord-337849-tyabf12r 18 48 ( ( -LRB- cord-337849-tyabf12r 18 49 hMPV hMPV NNP cord-337849-tyabf12r 18 50 ) ) -RRB- cord-337849-tyabf12r 18 51 ) ) -RRB- cord-337849-tyabf12r 18 52 , , , cord-337849-tyabf12r 18 53 coronaviruses coronaviruse NNS cord-337849-tyabf12r 18 54 , , , cord-337849-tyabf12r 18 55 adenoviruses adenovirus NNS cord-337849-tyabf12r 18 56 and and CC cord-337849-tyabf12r 18 57 human human JJ cord-337849-tyabf12r 18 58 bocavirus bocavirus NN cord-337849-tyabf12r 18 59 ( ( -LRB- cord-337849-tyabf12r 18 60 HBoV HBoV NNP cord-337849-tyabf12r 18 61 ) ) -RRB- cord-337849-tyabf12r 18 62 [ [ -LRB- cord-337849-tyabf12r 18 63 1 1 CD cord-337849-tyabf12r 18 64 ] ] -RRB- cord-337849-tyabf12r 18 65 [ [ -LRB- cord-337849-tyabf12r 18 66 2 2 CD cord-337849-tyabf12r 18 67 ] ] -RRB- cord-337849-tyabf12r 18 68 [ [ -LRB- cord-337849-tyabf12r 18 69 3 3 CD cord-337849-tyabf12r 18 70 ] ] -RRB- cord-337849-tyabf12r 18 71 [ [ -LRB- cord-337849-tyabf12r 18 72 4 4 CD cord-337849-tyabf12r 18 73 ] ] -RRB- cord-337849-tyabf12r 18 74 [ [ -LRB- cord-337849-tyabf12r 18 75 5 5 CD cord-337849-tyabf12r 18 76 ] ] -RRB- cord-337849-tyabf12r 18 77 . . . cord-337849-tyabf12r 19 1 The the DT cord-337849-tyabf12r 19 2 only only JJ cord-337849-tyabf12r 19 3 routinely routinely RB cord-337849-tyabf12r 19 4 administered administer VBN cord-337849-tyabf12r 19 5 vaccine vaccine NN cord-337849-tyabf12r 19 6 for for IN cord-337849-tyabf12r 19 7 a a DT cord-337849-tyabf12r 19 8 viral viral JJ cord-337849-tyabf12r 19 9 respiratory respiratory JJ cord-337849-tyabf12r 19 10 pathogen pathogen NN cord-337849-tyabf12r 19 11 in in IN cord-337849-tyabf12r 19 12 the the DT cord-337849-tyabf12r 19 13 UK UK NNP cord-337849-tyabf12r 19 14 is be VBZ cord-337849-tyabf12r 19 15 against against IN cord-337849-tyabf12r 19 16 seasonal seasonal JJ cord-337849-tyabf12r 19 17 influenza influenza NN cord-337849-tyabf12r 19 18 : : : cord-337849-tyabf12r 19 19 this this DT cord-337849-tyabf12r 19 20 is be VBZ cord-337849-tyabf12r 19 21 not not RB cord-337849-tyabf12r 19 22 100 100 CD cord-337849-tyabf12r 19 23 % % NN cord-337849-tyabf12r 19 24 effective effective JJ cord-337849-tyabf12r 19 25 and and CC cord-337849-tyabf12r 19 26 may may MD cord-337849-tyabf12r 19 27 offer offer VB cord-337849-tyabf12r 19 28 varying vary VBG cord-337849-tyabf12r 19 29 levels level NNS cord-337849-tyabf12r 19 30 of of IN cord-337849-tyabf12r 19 31 protection protection NN cord-337849-tyabf12r 19 32 against against IN cord-337849-tyabf12r 19 33 influenza influenza NN cord-337849-tyabf12r 19 34 infection infection NN cord-337849-tyabf12r 19 35 in in IN cord-337849-tyabf12r 19 36 different different JJ cord-337849-tyabf12r 19 37 seasons season NNS cord-337849-tyabf12r 19 38 and and CC cord-337849-tyabf12r 19 39 different different JJ cord-337849-tyabf12r 19 40 age age NN cord-337849-tyabf12r 19 41 groups group NNS cord-337849-tyabf12r 19 42 [ [ -LRB- cord-337849-tyabf12r 19 43 6 6 CD cord-337849-tyabf12r 19 44 ] ] -RRB- cord-337849-tyabf12r 19 45 . . . cord-337849-tyabf12r 20 1 The the DT cord-337849-tyabf12r 20 2 availability availability NN cord-337849-tyabf12r 20 3 of of IN cord-337849-tyabf12r 20 4 effective effective JJ cord-337849-tyabf12r 20 5 antiviral antiviral JJ cord-337849-tyabf12r 20 6 drugs drug NNS cord-337849-tyabf12r 20 7 is be VBZ cord-337849-tyabf12r 20 8 also also RB cord-337849-tyabf12r 20 9 limited limit VBN cord-337849-tyabf12r 20 10 , , , cord-337849-tyabf12r 20 11 with with IN cord-337849-tyabf12r 20 12 the the DT cord-337849-tyabf12r 20 13 effectiveness effectiveness NN cord-337849-tyabf12r 20 14 of of IN cord-337849-tyabf12r 20 15 approved approve VBN cord-337849-tyabf12r 20 16 influenza influenza NN cord-337849-tyabf12r 20 17 treatments treatment NNS cord-337849-tyabf12r 20 18 , , , cord-337849-tyabf12r 20 19 such such JJ cord-337849-tyabf12r 20 20 as as IN cord-337849-tyabf12r 20 21 Oseltamivir Oseltamivir NNP cord-337849-tyabf12r 20 22 ( ( -LRB- cord-337849-tyabf12r 20 23 Tamiflu Tamiflu NNP cord-337849-tyabf12r 20 24 ) ) -RRB- cord-337849-tyabf12r 20 25 , , , cord-337849-tyabf12r 20 26 debated debate VBD cord-337849-tyabf12r 20 27 [ [ -LRB- cord-337849-tyabf12r 20 28 7 7 CD cord-337849-tyabf12r 20 29 ] ] -RRB- cord-337849-tyabf12r 20 30 [ [ -LRB- cord-337849-tyabf12r 20 31 8 8 CD cord-337849-tyabf12r 20 32 ] ] -RRB- cord-337849-tyabf12r 20 33 [ [ -LRB- cord-337849-tyabf12r 20 34 9 9 CD cord-337849-tyabf12r 20 35 ] ] -RRB- cord-337849-tyabf12r 20 36 , , , cord-337849-tyabf12r 20 37 and and CC cord-337849-tyabf12r 20 38 no no DT cord-337849-tyabf12r 20 39 clinical clinical JJ cord-337849-tyabf12r 20 40 treatments treatment NNS cord-337849-tyabf12r 20 41 for for IN cord-337849-tyabf12r 20 42 common common JJ cord-337849-tyabf12r 20 43 respiratory respiratory JJ cord-337849-tyabf12r 20 44 viruses virus NNS cord-337849-tyabf12r 20 45 such such JJ cord-337849-tyabf12r 20 46 as as IN cord-337849-tyabf12r 20 47 rhinoviruses rhinovirus NNS cord-337849-tyabf12r 20 48 . . . cord-337849-tyabf12r 21 1 New new JJ cord-337849-tyabf12r 21 2 agents agent NNS cord-337849-tyabf12r 21 3 to to TO cord-337849-tyabf12r 21 4 prevent prevent VB cord-337849-tyabf12r 21 5 and and CC cord-337849-tyabf12r 21 6 treat treat VB cord-337849-tyabf12r 21 7 viral viral JJ cord-337849-tyabf12r 21 8 respiratory respiratory JJ cord-337849-tyabf12r 21 9 infection infection NN cord-337849-tyabf12r 21 10 are be VBP cord-337849-tyabf12r 21 11 needed need VBN cord-337849-tyabf12r 22 1 : : : cord-337849-tyabf12r 22 2 the the DT cord-337849-tyabf12r 22 3 WHO WHO NNP cord-337849-tyabf12r 22 4 initiative initiative NN cord-337849-tyabf12r 23 1 BRaVe brave ADD cord-337849-tyabf12r 23 2 ( ( -LRB- cord-337849-tyabf12r 23 3 Battle battle NN cord-337849-tyabf12r 23 4 against against IN cord-337849-tyabf12r 23 5 Respiratory respiratory JJ cord-337849-tyabf12r 23 6 Viruses virus NNS cord-337849-tyabf12r 23 7 ) ) -RRB- cord-337849-tyabf12r 23 8 has have VBZ cord-337849-tyabf12r 23 9 recently recently RB cord-337849-tyabf12r 23 10 been be VBN cord-337849-tyabf12r 23 11 established establish VBN cord-337849-tyabf12r 23 12 to to TO cord-337849-tyabf12r 23 13 aid aid VB cord-337849-tyabf12r 23 14 in in IN cord-337849-tyabf12r 23 15 the the DT cord-337849-tyabf12r 23 16 goal goal NN cord-337849-tyabf12r 23 17 of of IN cord-337849-tyabf12r 23 18 developing develop VBG cord-337849-tyabf12r 23 19 new new JJ cord-337849-tyabf12r 23 20 pharmacologic pharmacologic JJ cord-337849-tyabf12r 23 21 interventions intervention NNS cord-337849-tyabf12r 23 22 to to TO cord-337849-tyabf12r 23 23 prevent prevent VB cord-337849-tyabf12r 23 24 and and CC cord-337849-tyabf12r 23 25 treat treat VB cord-337849-tyabf12r 23 26 respiratory respiratory JJ cord-337849-tyabf12r 23 27 viruses virus NNS cord-337849-tyabf12r 23 28 [ [ -LRB- cord-337849-tyabf12r 23 29 10 10 CD cord-337849-tyabf12r 23 30 ] ] -RRB- cord-337849-tyabf12r 23 31 . . . cord-337849-tyabf12r 24 1 Vitamin vitamin NN cord-337849-tyabf12r 24 2 D d NN cord-337849-tyabf12r 24 3 is be VBZ cord-337849-tyabf12r 24 4 an an DT cord-337849-tyabf12r 24 5 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 24 6 micronutrient micronutrient NN cord-337849-tyabf12r 24 7 [ [ -LRB- cord-337849-tyabf12r 24 8 11 11 CD cord-337849-tyabf12r 24 9 , , , cord-337849-tyabf12r 24 10 12 12 CD cord-337849-tyabf12r 24 11 ] ] -RRB- cord-337849-tyabf12r 24 12 . . . cord-337849-tyabf12r 25 1 As as IN cord-337849-tyabf12r 25 2 reviewed review VBN cord-337849-tyabf12r 25 3 elsewhere elsewhere RB cord-337849-tyabf12r 25 4 [ [ -LRB- cord-337849-tyabf12r 25 5 13 13 CD cord-337849-tyabf12r 25 6 ] ] -RRB- cord-337849-tyabf12r 25 7 , , , cord-337849-tyabf12r 25 8 a a DT cord-337849-tyabf12r 25 9 number number NN cord-337849-tyabf12r 25 10 of of IN cord-337849-tyabf12r 25 11 observational observational JJ cord-337849-tyabf12r 25 12 studies study NNS cord-337849-tyabf12r 25 13 have have VBP cord-337849-tyabf12r 25 14 been be VBN cord-337849-tyabf12r 25 15 carried carry VBN cord-337849-tyabf12r 25 16 out out RP cord-337849-tyabf12r 25 17 to to TO cord-337849-tyabf12r 25 18 determine determine VB cord-337849-tyabf12r 25 19 the the DT cord-337849-tyabf12r 25 20 relationship relationship NN cord-337849-tyabf12r 25 21 between between IN cord-337849-tyabf12r 25 22 vitamin vitamin NN cord-337849-tyabf12r 25 23 D d NN cord-337849-tyabf12r 25 24 status status NN cord-337849-tyabf12r 25 25 and and CC cord-337849-tyabf12r 25 26 acute acute JJ cord-337849-tyabf12r 25 27 respiratory respiratory JJ cord-337849-tyabf12r 25 28 viral viral JJ cord-337849-tyabf12r 25 29 infections infection NNS cord-337849-tyabf12r 25 30 , , , cord-337849-tyabf12r 25 31 with with IN cord-337849-tyabf12r 25 32 the the DT cord-337849-tyabf12r 25 33 majority majority NN cord-337849-tyabf12r 25 34 demonstrating demonstrate VBG cord-337849-tyabf12r 25 35 independent independent JJ cord-337849-tyabf12r 25 36 associations association NNS cord-337849-tyabf12r 25 37 between between IN cord-337849-tyabf12r 25 38 low low JJ cord-337849-tyabf12r 25 39 vitamin vitamin NN cord-337849-tyabf12r 25 40 D d NN cord-337849-tyabf12r 25 41 status status NN cord-337849-tyabf12r 25 42 and and CC cord-337849-tyabf12r 25 43 increased increase VBN cord-337849-tyabf12r 25 44 risk risk NN cord-337849-tyabf12r 25 45 of of IN cord-337849-tyabf12r 25 46 acute acute JJ cord-337849-tyabf12r 25 47 viral viral JJ cord-337849-tyabf12r 25 48 respiratory respiratory JJ cord-337849-tyabf12r 25 49 infections infection NNS cord-337849-tyabf12r 25 50 . . . cord-337849-tyabf12r 26 1 Clinical clinical JJ cord-337849-tyabf12r 26 2 trials trial NNS cord-337849-tyabf12r 26 3 of of IN cord-337849-tyabf12r 26 4 vitamin vitamin NN cord-337849-tyabf12r 26 5 D d NN cord-337849-tyabf12r 26 6 supplementation supplementation NN cord-337849-tyabf12r 26 7 for for IN cord-337849-tyabf12r 26 8 the the DT cord-337849-tyabf12r 26 9 prevention prevention NN cord-337849-tyabf12r 26 10 of of IN cord-337849-tyabf12r 26 11 ARI ARI NNP cord-337849-tyabf12r 26 12 have have VBP cord-337849-tyabf12r 26 13 yielded yield VBN cord-337849-tyabf12r 26 14 heterogeneous heterogeneous JJ cord-337849-tyabf12r 26 15 results result NNS cord-337849-tyabf12r 26 16 [ [ -LRB- cord-337849-tyabf12r 26 17 14 14 CD cord-337849-tyabf12r 26 18 ] ] -RRB- cord-337849-tyabf12r 26 19 [ [ -LRB- cord-337849-tyabf12r 26 20 15 15 CD cord-337849-tyabf12r 26 21 ] ] -RRB- cord-337849-tyabf12r 26 22 [ [ -LRB- cord-337849-tyabf12r 26 23 16 16 CD cord-337849-tyabf12r 26 24 ] ] -RRB- cord-337849-tyabf12r 26 25 [ [ -LRB- cord-337849-tyabf12r 26 26 17 17 CD cord-337849-tyabf12r 26 27 ] ] -RRB- cord-337849-tyabf12r 26 28 [ [ -LRB- cord-337849-tyabf12r 26 29 18 18 CD cord-337849-tyabf12r 26 30 ] ] -RRB- cord-337849-tyabf12r 26 31 [ [ -LRB- cord-337849-tyabf12r 26 32 19 19 CD cord-337849-tyabf12r 26 33 ] ] -RRB- cord-337849-tyabf12r 26 34 [ [ -LRB- cord-337849-tyabf12r 26 35 20 20 CD cord-337849-tyabf12r 26 36 ] ] -RRB- cord-337849-tyabf12r 26 37 [ [ -LRB- cord-337849-tyabf12r 26 38 21 21 CD cord-337849-tyabf12r 26 39 ] ] -RRB- cord-337849-tyabf12r 26 40 [ [ -LRB- cord-337849-tyabf12r 26 41 22 22 CD cord-337849-tyabf12r 26 42 ] ] -RRB- cord-337849-tyabf12r 26 43 [ [ -LRB- cord-337849-tyabf12r 26 44 23 23 CD cord-337849-tyabf12r 26 45 ] ] -RRB- cord-337849-tyabf12r 27 1 [ [ -LRB- cord-337849-tyabf12r 27 2 24 24 CD cord-337849-tyabf12r 27 3 ] ] -RRB- cord-337849-tyabf12r 27 4 [ [ -LRB- cord-337849-tyabf12r 27 5 25 25 CD cord-337849-tyabf12r 27 6 ] ] -RRB- cord-337849-tyabf12r 27 7 [ [ -LRB- cord-337849-tyabf12r 27 8 26 26 CD cord-337849-tyabf12r 27 9 ] ] -RRB- cord-337849-tyabf12r 27 10 [ [ -LRB- cord-337849-tyabf12r 27 11 27 27 CD cord-337849-tyabf12r 27 12 ] ] -RRB- cord-337849-tyabf12r 27 13 , , , cord-337849-tyabf12r 27 14 with with IN cord-337849-tyabf12r 27 15 meta meta NNP cord-337849-tyabf12r 27 16 - - HYPH cord-337849-tyabf12r 27 17 analysis analysis NN cord-337849-tyabf12r 27 18 reporting report VBG cord-337849-tyabf12r 27 19 moderate moderate JJ cord-337849-tyabf12r 27 20 protective protective JJ cord-337849-tyabf12r 27 21 effects effect NNS cord-337849-tyabf12r 27 22 overall overall JJ cord-337849-tyabf12r 27 23 [ [ -LRB- cord-337849-tyabf12r 27 24 28 28 CD cord-337849-tyabf12r 27 25 ] ] -RRB- cord-337849-tyabf12r 27 26 . . . cord-337849-tyabf12r 28 1 A a DT cord-337849-tyabf12r 28 2 number number NN cord-337849-tyabf12r 28 3 of of IN cord-337849-tyabf12r 28 4 in in FW cord-337849-tyabf12r 28 5 vitro vitro FW cord-337849-tyabf12r 28 6 studies study NNS cord-337849-tyabf12r 28 7 have have VBP cord-337849-tyabf12r 28 8 investigated investigate VBN cord-337849-tyabf12r 28 9 the the DT cord-337849-tyabf12r 28 10 effects effect NNS cord-337849-tyabf12r 28 11 of of IN cord-337849-tyabf12r 28 12 vitamin vitamin NN cord-337849-tyabf12r 28 13 D d NN cord-337849-tyabf12r 28 14 metabolites metabolite NNS cord-337849-tyabf12r 28 15 on on IN cord-337849-tyabf12r 28 16 host host NN cord-337849-tyabf12r 28 17 immune immune JJ cord-337849-tyabf12r 28 18 responses response NNS cord-337849-tyabf12r 28 19 to to IN cord-337849-tyabf12r 28 20 respiratory respiratory JJ cord-337849-tyabf12r 28 21 viruses virus NNS cord-337849-tyabf12r 28 22 , , , cord-337849-tyabf12r 28 23 but but CC cord-337849-tyabf12r 28 24 recent recent JJ cord-337849-tyabf12r 28 25 syntheses synthesis NNS cord-337849-tyabf12r 28 26 of of IN cord-337849-tyabf12r 28 27 this this DT cord-337849-tyabf12r 28 28 literature literature NN cord-337849-tyabf12r 28 29 are be VBP cord-337849-tyabf12r 28 30 lacking lack VBG cord-337849-tyabf12r 28 31 . . . cord-337849-tyabf12r 29 1 In in IN cord-337849-tyabf12r 29 2 order order NN cord-337849-tyabf12r 29 3 to to TO cord-337849-tyabf12r 29 4 review review VB cord-337849-tyabf12r 29 5 these these DT cord-337849-tyabf12r 29 6 studies study NNS cord-337849-tyabf12r 29 7 the the DT cord-337849-tyabf12r 29 8 PubMed PubMed NNP cord-337849-tyabf12r 29 9 database database NN cord-337849-tyabf12r 29 10 was be VBD cord-337849-tyabf12r 29 11 searched search VBN cord-337849-tyabf12r 29 12 using use VBG cord-337849-tyabf12r 29 13 the the DT cord-337849-tyabf12r 29 14 terms term NNS cord-337849-tyabf12r 29 15 " " `` cord-337849-tyabf12r 29 16 vitamin vitamin NN cord-337849-tyabf12r 29 17 D d NN cord-337849-tyabf12r 29 18 " " '' cord-337849-tyabf12r 29 19 with with IN cord-337849-tyabf12r 29 20 the the DT cord-337849-tyabf12r 29 21 following follow VBG cord-337849-tyabf12r 29 22 respiratory respiratory JJ cord-337849-tyabf12r 29 23 viruses virus NNS cord-337849-tyabf12r 29 24 ( ( -LRB- cord-337849-tyabf12r 29 25 rhinovirus rhinovirus NN cord-337849-tyabf12r 29 26 , , , cord-337849-tyabf12r 29 27 RSV RSV NNP cord-337849-tyabf12r 29 28 , , , cord-337849-tyabf12r 29 29 influenza influenza NN cord-337849-tyabf12r 29 30 , , , cord-337849-tyabf12r 29 31 parainfluenza parainfluenza NNP cord-337849-tyabf12r 29 32 , , , cord-337849-tyabf12r 29 33 human human NNP cord-337849-tyabf12r 29 34 metapneumovirus metapneumovirus NNP cord-337849-tyabf12r 29 35 , , , cord-337849-tyabf12r 29 36 coronavirus coronavirus NN cord-337849-tyabf12r 29 37 , , , cord-337849-tyabf12r 29 38 adenovirus adenovirus NN cord-337849-tyabf12r 29 39 , , , cord-337849-tyabf12r 29 40 enterovirus enterovirus NN cord-337849-tyabf12r 29 41 and and CC cord-337849-tyabf12r 29 42 human human JJ cord-337849-tyabf12r 29 43 bocavirus bocavirus NNP cord-337849-tyabf12r 29 44 ) ) -RRB- cord-337849-tyabf12r 29 45 to to TO cord-337849-tyabf12r 29 46 ensure ensure VB cord-337849-tyabf12r 29 47 a a DT cord-337849-tyabf12r 29 48 systematic systematic JJ cord-337849-tyabf12r 29 49 review review NN cord-337849-tyabf12r 29 50 of of IN cord-337849-tyabf12r 29 51 the the DT cord-337849-tyabf12r 29 52 available available JJ cord-337849-tyabf12r 29 53 literature literature NN cord-337849-tyabf12r 29 54 . . . cord-337849-tyabf12r 30 1 Inclusion inclusion NN cord-337849-tyabf12r 30 2 criteria criterion NNS cord-337849-tyabf12r 30 3 were be VBD cord-337849-tyabf12r 30 4 studies study NNS cord-337849-tyabf12r 30 5 which which WDT cord-337849-tyabf12r 30 6 provided provide VBN cord-337849-tyabf12r 30 7 in in IN cord-337849-tyabf12r 30 8 vitro vitro FW cord-337849-tyabf12r 30 9 evidence evidence NN cord-337849-tyabf12r 30 10 as as IN cord-337849-tyabf12r 30 11 opposed oppose VBN cord-337849-tyabf12r 30 12 to to IN cord-337849-tyabf12r 30 13 solely solely RB cord-337849-tyabf12r 30 14 clinical clinical JJ cord-337849-tyabf12r 30 15 studies study NNS cord-337849-tyabf12r 30 16 , , , cord-337849-tyabf12r 30 17 the the DT cord-337849-tyabf12r 30 18 availability availability NN cord-337849-tyabf12r 30 19 of of IN cord-337849-tyabf12r 30 20 the the DT cord-337849-tyabf12r 30 21 full full JJ cord-337849-tyabf12r 30 22 text text NN cord-337849-tyabf12r 30 23 , , , cord-337849-tyabf12r 30 24 and and CC cord-337849-tyabf12r 30 25 for for IN cord-337849-tyabf12r 30 26 virus virus NN cord-337849-tyabf12r 30 27 genera genus NNS cord-337849-tyabf12r 30 28 , , , cord-337849-tyabf12r 30 29 such such JJ cord-337849-tyabf12r 30 30 as as IN cord-337849-tyabf12r 30 31 enterovirus enterovirus NN cord-337849-tyabf12r 30 32 , , , cord-337849-tyabf12r 30 33 which which WDT cord-337849-tyabf12r 30 34 can can MD cord-337849-tyabf12r 30 35 infect infect VB cord-337849-tyabf12r 30 36 multiple multiple JJ cord-337849-tyabf12r 30 37 sites site NNS cord-337849-tyabf12r 30 38 , , , cord-337849-tyabf12r 30 39 the the DT cord-337849-tyabf12r 30 40 use use NN cord-337849-tyabf12r 30 41 of of IN cord-337849-tyabf12r 30 42 species specie NNS cord-337849-tyabf12r 30 43 or or CC cord-337849-tyabf12r 30 44 serotypes serotype NNS cord-337849-tyabf12r 30 45 specifically specifically RB cord-337849-tyabf12r 30 46 associated associate VBN cord-337849-tyabf12r 30 47 with with IN cord-337849-tyabf12r 30 48 respiratory respiratory JJ cord-337849-tyabf12r 30 49 disease disease NN cord-337849-tyabf12r 30 50 . . . cord-337849-tyabf12r 31 1 When when WRB cord-337849-tyabf12r 31 2 a a DT cord-337849-tyabf12r 31 3 respiratory respiratory JJ cord-337849-tyabf12r 31 4 virus virus NN cord-337849-tyabf12r 31 5 is be VBZ cord-337849-tyabf12r 31 6 inhaled inhale VBN cord-337849-tyabf12r 31 7 it -PRON- PRP cord-337849-tyabf12r 31 8 first first RB cord-337849-tyabf12r 31 9 binds bind VBZ cord-337849-tyabf12r 31 10 to to IN cord-337849-tyabf12r 31 11 non non JJ cord-337849-tyabf12r 31 12 - - JJ cord-337849-tyabf12r 31 13 specific specific JJ cord-337849-tyabf12r 31 14 receptors receptor NNS cord-337849-tyabf12r 31 15 on on IN cord-337849-tyabf12r 31 16 the the DT cord-337849-tyabf12r 31 17 respiratory respiratory JJ cord-337849-tyabf12r 31 18 epithelium epithelium NN cord-337849-tyabf12r 31 19 , , , cord-337849-tyabf12r 31 20 usually usually RB cord-337849-tyabf12r 31 21 glycolipids glycolipid NNS cord-337849-tyabf12r 31 22 or or CC cord-337849-tyabf12r 31 23 glycoproteins glycoprotein NNS cord-337849-tyabf12r 31 24 such such JJ cord-337849-tyabf12r 31 25 as as IN cord-337849-tyabf12r 31 26 intercellular intercellular JJ cord-337849-tyabf12r 31 27 adhesion adhesion NN cord-337849-tyabf12r 31 28 molecule molecule NN cord-337849-tyabf12r 31 29 ( ( -LRB- cord-337849-tyabf12r 32 1 ICAM)-1 ICAM)-1 NNP cord-337849-tyabf12r 32 2 . . . cord-337849-tyabf12r 33 1 Membrane membrane NN cord-337849-tyabf12r 33 2 fusion fusion NN cord-337849-tyabf12r 33 3 or or CC cord-337849-tyabf12r 33 4 endocytosis endocytosis NN cord-337849-tyabf12r 33 5 follows follow VBZ cord-337849-tyabf12r 33 6 , , , cord-337849-tyabf12r 33 7 thus thus RB cord-337849-tyabf12r 33 8 internalizing internalize VBG cord-337849-tyabf12r 33 9 the the DT cord-337849-tyabf12r 33 10 virus virus NN cord-337849-tyabf12r 33 11 and and CC cord-337849-tyabf12r 33 12 enabling enable VBG cord-337849-tyabf12r 33 13 subsequent subsequent JJ cord-337849-tyabf12r 33 14 replication replication NN cord-337849-tyabf12r 33 15 , , , cord-337849-tyabf12r 33 16 transcription transcription NN cord-337849-tyabf12r 33 17 and and CC cord-337849-tyabf12r 33 18 translation translation NN cord-337849-tyabf12r 33 19 of of IN cord-337849-tyabf12r 33 20 new new JJ cord-337849-tyabf12r 33 21 viruses virus NNS cord-337849-tyabf12r 33 22 which which WDT cord-337849-tyabf12r 33 23 can can MD cord-337849-tyabf12r 33 24 then then RB cord-337849-tyabf12r 33 25 be be VB cord-337849-tyabf12r 33 26 released release VBN cord-337849-tyabf12r 33 27 to to TO cord-337849-tyabf12r 33 28 infect infect VB cord-337849-tyabf12r 33 29 new new JJ cord-337849-tyabf12r 33 30 cells cell NNS cord-337849-tyabf12r 33 31 . . . cord-337849-tyabf12r 34 1 However however RB cord-337849-tyabf12r 34 2 , , , cord-337849-tyabf12r 34 3 once once RB cord-337849-tyabf12r 34 4 a a DT cord-337849-tyabf12r 34 5 cell cell NN cord-337849-tyabf12r 34 6 has have VBZ cord-337849-tyabf12r 34 7 been be VBN cord-337849-tyabf12r 34 8 infected infect VBN cord-337849-tyabf12r 34 9 , , , cord-337849-tyabf12r 34 10 pathogen pathogen NN cord-337849-tyabf12r 34 11 - - HYPH cord-337849-tyabf12r 34 12 associated associate VBN cord-337849-tyabf12r 34 13 molecular molecular JJ cord-337849-tyabf12r 34 14 patterns pattern NNS cord-337849-tyabf12r 34 15 ( ( -LRB- cord-337849-tyabf12r 34 16 PAMPs pamp NNS cord-337849-tyabf12r 34 17 ) ) -RRB- cord-337849-tyabf12r 34 18 on on IN cord-337849-tyabf12r 34 19 the the DT cord-337849-tyabf12r 34 20 virus virus NN cord-337849-tyabf12r 34 21 can can MD cord-337849-tyabf12r 34 22 be be VB cord-337849-tyabf12r 34 23 recognised recognise VBN cord-337849-tyabf12r 34 24 by by IN cord-337849-tyabf12r 34 25 various various JJ cord-337849-tyabf12r 34 26 intracellular intracellular JJ cord-337849-tyabf12r 34 27 innate innate JJ cord-337849-tyabf12r 34 28 pathogen pathogen NN cord-337849-tyabf12r 34 29 recognition recognition NN cord-337849-tyabf12r 34 30 receptors receptor NNS cord-337849-tyabf12r 34 31 ( ( -LRB- cord-337849-tyabf12r 34 32 PRRs PRRs NNP cord-337849-tyabf12r 34 33 ) ) -RRB- cord-337849-tyabf12r 34 34 such such JJ cord-337849-tyabf12r 34 35 as as IN cord-337849-tyabf12r 34 36 the the DT cord-337849-tyabf12r 34 37 toll toll NN cord-337849-tyabf12r 34 38 - - HYPH cord-337849-tyabf12r 34 39 like like JJ cord-337849-tyabf12r 34 40 receptors receptor NNS cord-337849-tyabf12r 34 41 ( ( -LRB- cord-337849-tyabf12r 34 42 TLRs TLRs NNP cord-337849-tyabf12r 34 43 ) ) -RRB- cord-337849-tyabf12r 34 44 , , , cord-337849-tyabf12r 34 45 retinoic retinoic JJ cord-337849-tyabf12r 34 46 - - HYPH cord-337849-tyabf12r 34 47 acid acid NN cord-337849-tyabf12r 34 48 - - HYPH cord-337849-tyabf12r 34 49 inducible inducible JJ cord-337849-tyabf12r 34 50 gene- gene- NN cord-337849-tyabf12r 35 1 I -PRON- PRP cord-337849-tyabf12r 35 2 ( ( -LRB- cord-337849-tyabf12r 35 3 RIG RIG NNP cord-337849-tyabf12r 35 4 - - HYPH cord-337849-tyabf12r 35 5 I)-like I)-like NNP cord-337849-tyabf12r 35 6 receptors receptor NNS cord-337849-tyabf12r 35 7 ( ( -LRB- cord-337849-tyabf12r 35 8 RLRs rlr NNS cord-337849-tyabf12r 35 9 ) ) -RRB- cord-337849-tyabf12r 35 10 and and CC cord-337849-tyabf12r 35 11 nucleotide nucleotide JJ cord-337849-tyabf12r 35 12 binding binding NN cord-337849-tyabf12r 35 13 - - HYPH cord-337849-tyabf12r 35 14 oligomerisation oligomerisation NN cord-337849-tyabf12r 35 15 domain domain NN cord-337849-tyabf12r 35 16 ( ( -LRB- cord-337849-tyabf12r 35 17 NOD)-like nod)-like CD cord-337849-tyabf12r 35 18 receptors receptor NNS cord-337849-tyabf12r 35 19 ( ( -LRB- cord-337849-tyabf12r 35 20 NLRs NLRs NNP cord-337849-tyabf12r 35 21 ) ) -RRB- cord-337849-tyabf12r 35 22 . . . cord-337849-tyabf12r 36 1 Pulmonary pulmonary JJ cord-337849-tyabf12r 36 2 epithelial epithelial JJ cord-337849-tyabf12r 36 3 cells cell NNS cord-337849-tyabf12r 36 4 have have VBP cord-337849-tyabf12r 36 5 been be VBN cord-337849-tyabf12r 36 6 shown show VBN cord-337849-tyabf12r 36 7 to to TO cord-337849-tyabf12r 36 8 express express VB cord-337849-tyabf12r 36 9 all all DT cord-337849-tyabf12r 36 10 of of IN cord-337849-tyabf12r 36 11 the the DT cord-337849-tyabf12r 36 12 known know VBN cord-337849-tyabf12r 36 13 human human JJ cord-337849-tyabf12r 36 14 TLRs tlr NNS cord-337849-tyabf12r 36 15 and and CC cord-337849-tyabf12r 36 16 RLRs rlr NNS cord-337849-tyabf12r 36 17 which which WDT cord-337849-tyabf12r 36 18 detect detect VBP cord-337849-tyabf12r 36 19 viruses virus NNS cord-337849-tyabf12r 36 20 , , , cord-337849-tyabf12r 36 21 and and CC cord-337849-tyabf12r 36 22 ligands ligand NNS cord-337849-tyabf12r 36 23 for for IN cord-337849-tyabf12r 36 24 these these DT cord-337849-tyabf12r 36 25 PRRs prr NNS cord-337849-tyabf12r 36 26 activate activate VBP cord-337849-tyabf12r 36 27 epithelial epithelial JJ cord-337849-tyabf12r 36 28 cells cell NNS cord-337849-tyabf12r 36 29 in in IN cord-337849-tyabf12r 36 30 order order NN cord-337849-tyabf12r 36 31 to to TO cord-337849-tyabf12r 36 32 initiate initiate VB cord-337849-tyabf12r 36 33 a a DT cord-337849-tyabf12r 36 34 rapid rapid JJ cord-337849-tyabf12r 36 35 immune immune JJ cord-337849-tyabf12r 36 36 response response NN cord-337849-tyabf12r 36 37 against against IN cord-337849-tyabf12r 36 38 viral viral JJ cord-337849-tyabf12r 36 39 invasion invasion NN cord-337849-tyabf12r 36 40 [ [ -LRB- cord-337849-tyabf12r 36 41 29 29 CD cord-337849-tyabf12r 36 42 ] ] -RRB- cord-337849-tyabf12r 36 43 . . . cord-337849-tyabf12r 37 1 In in IN cord-337849-tyabf12r 37 2 addition addition NN cord-337849-tyabf12r 37 3 to to IN cord-337849-tyabf12r 37 4 direct direct JJ cord-337849-tyabf12r 37 5 infection infection NN cord-337849-tyabf12r 37 6 of of IN cord-337849-tyabf12r 37 7 epithelial epithelial JJ cord-337849-tyabf12r 37 8 cells cell NNS cord-337849-tyabf12r 37 9 , , , cord-337849-tyabf12r 37 10 intraepithelial intraepithelial JJ cord-337849-tyabf12r 37 11 dendritic dendritic JJ cord-337849-tyabf12r 37 12 cells cell NNS cord-337849-tyabf12r 37 13 ( ( -LRB- cord-337849-tyabf12r 37 14 DCs DCs NNP cord-337849-tyabf12r 37 15 ) ) -RRB- cord-337849-tyabf12r 37 16 , , , cord-337849-tyabf12r 37 17 DCs DCs NNP cord-337849-tyabf12r 37 18 residing reside VBG cord-337849-tyabf12r 37 19 just just RB cord-337849-tyabf12r 37 20 below below IN cord-337849-tyabf12r 37 21 the the DT cord-337849-tyabf12r 37 22 respiratory respiratory JJ cord-337849-tyabf12r 37 23 epithelium epithelium NN cord-337849-tyabf12r 37 24 , , , cord-337849-tyabf12r 37 25 and and CC cord-337849-tyabf12r 37 26 tissue tissue NN cord-337849-tyabf12r 37 27 - - HYPH cord-337849-tyabf12r 37 28 resident resident NN cord-337849-tyabf12r 37 29 macrophages macrophage NNS cord-337849-tyabf12r 37 30 continually continually RB cord-337849-tyabf12r 37 31 sample sample VBP cord-337849-tyabf12r 37 32 particles particle NNS cord-337849-tyabf12r 37 33 in in IN cord-337849-tyabf12r 37 34 the the DT cord-337849-tyabf12r 37 35 airway airway NN cord-337849-tyabf12r 37 36 lumen lumen NN cord-337849-tyabf12r 37 37 and and CC cord-337849-tyabf12r 37 38 can can MD cord-337849-tyabf12r 37 39 internalize internalize VB cord-337849-tyabf12r 37 40 them -PRON- PRP cord-337849-tyabf12r 37 41 by by IN cord-337849-tyabf12r 37 42 phagocytosis phagocytosis NN cord-337849-tyabf12r 37 43 and and CC cord-337849-tyabf12r 37 44 macropinocytosis macropinocytosis NN cord-337849-tyabf12r 37 45 , , , cord-337849-tyabf12r 37 46 thus thus RB cord-337849-tyabf12r 37 47 activating activate VBG cord-337849-tyabf12r 37 48 PRRs prr NNS cord-337849-tyabf12r 37 49 and and CC cord-337849-tyabf12r 37 50 initiating initiate VBG cord-337849-tyabf12r 37 51 an an DT cord-337849-tyabf12r 37 52 immune immune JJ cord-337849-tyabf12r 37 53 response response NN cord-337849-tyabf12r 37 54 [ [ -LRB- cord-337849-tyabf12r 37 55 30 30 CD cord-337849-tyabf12r 37 56 , , , cord-337849-tyabf12r 37 57 31 31 CD cord-337849-tyabf12r 37 58 ] ] -RRB- cord-337849-tyabf12r 37 59 . . . cord-337849-tyabf12r 38 1 The the DT cord-337849-tyabf12r 38 2 intracellular intracellular JJ cord-337849-tyabf12r 38 3 TLRs TLRs NNP cord-337849-tyabf12r 38 4 3 3 CD cord-337849-tyabf12r 38 5 , , , cord-337849-tyabf12r 38 6 7 7 CD cord-337849-tyabf12r 38 7 , , , cord-337849-tyabf12r 38 8 8 8 CD cord-337849-tyabf12r 38 9 and and CC cord-337849-tyabf12r 38 10 9 9 CD cord-337849-tyabf12r 38 11 are be VBP cord-337849-tyabf12r 38 12 mainly mainly RB cord-337849-tyabf12r 38 13 located locate VBN cord-337849-tyabf12r 38 14 on on IN cord-337849-tyabf12r 38 15 the the DT cord-337849-tyabf12r 38 16 endoplasmic endoplasmic NN cord-337849-tyabf12r 38 17 reticulum reticulum NN cord-337849-tyabf12r 38 18 ( ( -LRB- cord-337849-tyabf12r 38 19 ER er NN cord-337849-tyabf12r 38 20 ) ) -RRB- cord-337849-tyabf12r 38 21 membrane membrane NN cord-337849-tyabf12r 38 22 before before IN cord-337849-tyabf12r 38 23 UNC93B1-dependent UNC93B1-dependent NNP cord-337849-tyabf12r 38 24 ( ( -LRB- cord-337849-tyabf12r 38 25 an an DT cord-337849-tyabf12r 38 26 ER ER NNP cord-337849-tyabf12r 38 27 multi multi JJ cord-337849-tyabf12r 38 28 - - JJ cord-337849-tyabf12r 38 29 transmembrane transmembrane JJ cord-337849-tyabf12r 38 30 - - HYPH cord-337849-tyabf12r 38 31 domain domain NN cord-337849-tyabf12r 38 32 - - HYPH cord-337849-tyabf12r 38 33 containing contain VBG cord-337849-tyabf12r 38 34 protein protein NN cord-337849-tyabf12r 38 35 ) ) -RRB- cord-337849-tyabf12r 38 36 trafficking trafficking NN cord-337849-tyabf12r 38 37 to to IN cord-337849-tyabf12r 38 38 the the DT cord-337849-tyabf12r 38 39 endolysosome endolysosome NN cord-337849-tyabf12r 38 40 following follow VBG cord-337849-tyabf12r 38 41 viral viral JJ cord-337849-tyabf12r 38 42 infection infection NN cord-337849-tyabf12r 38 43 [ [ -LRB- cord-337849-tyabf12r 38 44 32 32 CD cord-337849-tyabf12r 38 45 , , , cord-337849-tyabf12r 38 46 33 33 CD cord-337849-tyabf12r 38 47 ] ] -RRB- cord-337849-tyabf12r 38 48 . . . cord-337849-tyabf12r 39 1 These these DT cord-337849-tyabf12r 39 2 nucleic nucleic JJ cord-337849-tyabf12r 39 3 acid acid NN cord-337849-tyabf12r 39 4 - - HYPH cord-337849-tyabf12r 39 5 sensing sense VBG cord-337849-tyabf12r 39 6 TLRs tlr NNS cord-337849-tyabf12r 39 7 recognise recognise VBP cord-337849-tyabf12r 39 8 single single RB cord-337849-tyabf12r 39 9 - - HYPH cord-337849-tyabf12r 39 10 stranded strand VBN cord-337849-tyabf12r 39 11 RNA RNA NNP cord-337849-tyabf12r 39 12 ( ( -LRB- cord-337849-tyabf12r 39 13 TLR TLR NNP cord-337849-tyabf12r 39 14 7/8 7/8 CD cord-337849-tyabf12r 39 15 ) ) -RRB- cord-337849-tyabf12r 39 16 or or CC cord-337849-tyabf12r 39 17 unmethylated unmethylate VBN cord-337849-tyabf12r 39 18 CpG CpG NNP cord-337849-tyabf12r 39 19 double double RB cord-337849-tyabf12r 39 20 - - HYPH cord-337849-tyabf12r 39 21 stranded strand VBN cord-337849-tyabf12r 39 22 DNA dna NN cord-337849-tyabf12r 39 23 motifs motif NNS cord-337849-tyabf12r 39 24 ( ( -LRB- cord-337849-tyabf12r 39 25 TLR TLR NNP cord-337849-tyabf12r 39 26 9 9 CD cord-337849-tyabf12r 39 27 ) ) -RRB- cord-337849-tyabf12r 39 28 of of IN cord-337849-tyabf12r 39 29 the the DT cord-337849-tyabf12r 39 30 viral viral JJ cord-337849-tyabf12r 39 31 genome genome NN cord-337849-tyabf12r 39 32 , , , cord-337849-tyabf12r 39 33 or or CC cord-337849-tyabf12r 39 34 the the DT cord-337849-tyabf12r 39 35 intermediary intermediary JJ cord-337849-tyabf12r 39 36 double double RB cord-337849-tyabf12r 39 37 - - HYPH cord-337849-tyabf12r 39 38 stranded strand VBN cord-337849-tyabf12r 39 39 RNA RNA NNP cord-337849-tyabf12r 39 40 ( ( -LRB- cord-337849-tyabf12r 39 41 TLR TLR NNP cord-337849-tyabf12r 39 42 3 3 CD cord-337849-tyabf12r 39 43 ) ) -RRB- cord-337849-tyabf12r 39 44 produced produce VBD cord-337849-tyabf12r 39 45 during during IN cord-337849-tyabf12r 39 46 viral viral JJ cord-337849-tyabf12r 39 47 replication replication NN cord-337849-tyabf12r 39 48 [ [ -LRB- cord-337849-tyabf12r 39 49 34 34 CD cord-337849-tyabf12r 39 50 ] ] -RRB- cord-337849-tyabf12r 40 1 [ [ -LRB- cord-337849-tyabf12r 40 2 35 35 CD cord-337849-tyabf12r 40 3 ] ] -RRB- cord-337849-tyabf12r 40 4 [ [ -LRB- cord-337849-tyabf12r 40 5 36 36 CD cord-337849-tyabf12r 40 6 ] ] -RRB- cord-337849-tyabf12r 41 1 [ [ -LRB- cord-337849-tyabf12r 41 2 37 37 CD cord-337849-tyabf12r 41 3 ] ] -RRB- cord-337849-tyabf12r 41 4 . . . cord-337849-tyabf12r 42 1 Additionally additionally RB cord-337849-tyabf12r 42 2 , , , cord-337849-tyabf12r 42 3 TLR4 TLR4 NNP cord-337849-tyabf12r 42 4 and and CC cord-337849-tyabf12r 42 5 TLR2 TLR2 NNP cord-337849-tyabf12r 42 6 receptor receptor NN cord-337849-tyabf12r 42 7 complexes complex NNS cord-337849-tyabf12r 42 8 are be VBP cord-337849-tyabf12r 42 9 able able JJ cord-337849-tyabf12r 42 10 to to TO cord-337849-tyabf12r 42 11 traffic traffic VB cord-337849-tyabf12r 42 12 to to IN cord-337849-tyabf12r 42 13 the the DT cord-337849-tyabf12r 42 14 endolysosome endolysosome NN cord-337849-tyabf12r 42 15 and and CC cord-337849-tyabf12r 42 16 may may MD cord-337849-tyabf12r 42 17 play play VB cord-337849-tyabf12r 42 18 a a DT cord-337849-tyabf12r 42 19 role role NN cord-337849-tyabf12r 42 20 in in IN cord-337849-tyabf12r 42 21 viral viral JJ cord-337849-tyabf12r 42 22 recognition recognition NN cord-337849-tyabf12r 42 23 [ [ -LRB- cord-337849-tyabf12r 42 24 37 37 CD cord-337849-tyabf12r 42 25 ] ] -RRB- cord-337849-tyabf12r 42 26 [ [ -LRB- cord-337849-tyabf12r 42 27 38 38 CD cord-337849-tyabf12r 42 28 ] ] -RRB- cord-337849-tyabf12r 42 29 [ [ -LRB- cord-337849-tyabf12r 42 30 39 39 CD cord-337849-tyabf12r 42 31 ] ] -RRB- cord-337849-tyabf12r 42 32 [ [ -LRB- cord-337849-tyabf12r 42 33 40 40 CD cord-337849-tyabf12r 42 34 ] ] -RRB- cord-337849-tyabf12r 42 35 [ [ -LRB- cord-337849-tyabf12r 42 36 41 41 CD cord-337849-tyabf12r 42 37 ] ] -RRB- cord-337849-tyabf12r 42 38 . . . cord-337849-tyabf12r 43 1 Viruses virus NNS cord-337849-tyabf12r 43 2 which which WDT cord-337849-tyabf12r 43 3 avoid avoid VBP cord-337849-tyabf12r 43 4 recognition recognition NN cord-337849-tyabf12r 43 5 by by IN cord-337849-tyabf12r 43 6 TLRs TLRs NNP cord-337849-tyabf12r 43 7 , , , cord-337849-tyabf12r 43 8 can can MD cord-337849-tyabf12r 43 9 be be VB cord-337849-tyabf12r 43 10 recognised recognise VBN cord-337849-tyabf12r 43 11 by by IN cord-337849-tyabf12r 43 12 RLRs rlr NNS cord-337849-tyabf12r 43 13 which which WDT cord-337849-tyabf12r 43 14 are be VBP cord-337849-tyabf12r 43 15 present present JJ cord-337849-tyabf12r 43 16 throughout throughout IN cord-337849-tyabf12r 43 17 the the DT cord-337849-tyabf12r 43 18 cytosol cytosol NN cord-337849-tyabf12r 43 19 , , , cord-337849-tyabf12r 43 20 with with IN cord-337849-tyabf12r 43 21 RIG rig NN cord-337849-tyabf12r 43 22 - - : cord-337849-tyabf12r 43 23 I -PRON- PRP cord-337849-tyabf12r 43 24 important important JJ cord-337849-tyabf12r 43 25 in in IN cord-337849-tyabf12r 43 26 the the DT cord-337849-tyabf12r 43 27 immune immune JJ cord-337849-tyabf12r 43 28 response response NN cord-337849-tyabf12r 43 29 to to IN cord-337849-tyabf12r 43 30 many many JJ cord-337849-tyabf12r 43 31 RNA RNA NNP cord-337849-tyabf12r 43 32 viruses virus NNS cord-337849-tyabf12r 43 33 [ [ -LRB- cord-337849-tyabf12r 43 34 42 42 CD cord-337849-tyabf12r 43 35 ] ] -RRB- cord-337849-tyabf12r 43 36 , , , cord-337849-tyabf12r 43 37 and and CC cord-337849-tyabf12r 43 38 melanoma melanoma NN cord-337849-tyabf12r 43 39 differentiation differentiation NN cord-337849-tyabf12r 43 40 - - HYPH cord-337849-tyabf12r 43 41 associated associate VBN cord-337849-tyabf12r 43 42 gene gene NN cord-337849-tyabf12r 43 43 5 5 CD cord-337849-tyabf12r 43 44 ( ( -LRB- cord-337849-tyabf12r 43 45 MDA5 MDA5 NNP cord-337849-tyabf12r 43 46 ) ) -RRB- cord-337849-tyabf12r 43 47 crucial crucial JJ cord-337849-tyabf12r 43 48 in in IN cord-337849-tyabf12r 43 49 the the DT cord-337849-tyabf12r 43 50 recognition recognition NN cord-337849-tyabf12r 43 51 of of IN cord-337849-tyabf12r 43 52 picornaviruses picornavirus NNS cord-337849-tyabf12r 43 53 [ [ -LRB- cord-337849-tyabf12r 43 54 43 43 CD cord-337849-tyabf12r 43 55 ] ] -RRB- cord-337849-tyabf12r 43 56 . . . cord-337849-tyabf12r 44 1 Additionally additionally RB cord-337849-tyabf12r 44 2 , , , cord-337849-tyabf12r 44 3 the the DT cord-337849-tyabf12r 44 4 cytosolic cytosolic JJ cord-337849-tyabf12r 44 5 NLR NLR NNP cord-337849-tyabf12r 44 6 NOD2 NOD2 NNPS cord-337849-tyabf12r 44 7 , , , cord-337849-tyabf12r 44 8 whilst whilst IN cord-337849-tyabf12r 44 9 normally normally RB cord-337849-tyabf12r 44 10 associated associate VBN cord-337849-tyabf12r 44 11 with with IN cord-337849-tyabf12r 44 12 the the DT cord-337849-tyabf12r 44 13 recognition recognition NN cord-337849-tyabf12r 44 14 of of IN cord-337849-tyabf12r 44 15 bacterial bacterial JJ cord-337849-tyabf12r 44 16 muramyl muramyl NNP cord-337849-tyabf12r 44 17 dipeptide dipeptide NNP cord-337849-tyabf12r 44 18 , , , cord-337849-tyabf12r 44 19 has have VBZ cord-337849-tyabf12r 44 20 also also RB cord-337849-tyabf12r 44 21 been be VBN cord-337849-tyabf12r 44 22 demonstrated demonstrate VBN cord-337849-tyabf12r 44 23 to to TO cord-337849-tyabf12r 44 24 be be VB cord-337849-tyabf12r 44 25 involved involve VBN cord-337849-tyabf12r 44 26 in in IN cord-337849-tyabf12r 44 27 the the DT cord-337849-tyabf12r 44 28 recognition recognition NN cord-337849-tyabf12r 44 29 of of IN cord-337849-tyabf12r 44 30 the the DT cord-337849-tyabf12r 44 31 ssRNA ssRNA NNP cord-337849-tyabf12r 44 32 genome genome NN cord-337849-tyabf12r 44 33 of of IN cord-337849-tyabf12r 44 34 RSV RSV NNP cord-337849-tyabf12r 44 35 [ [ -LRB- cord-337849-tyabf12r 44 36 44 44 CD cord-337849-tyabf12r 44 37 ] ] -RRB- cord-337849-tyabf12r 44 38 . . . cord-337849-tyabf12r 45 1 Despite despite IN cord-337849-tyabf12r 45 2 differences difference NNS cord-337849-tyabf12r 45 3 in in IN cord-337849-tyabf12r 45 4 viral viral JJ cord-337849-tyabf12r 45 5 genomes genome NNS cord-337849-tyabf12r 45 6 , , , cord-337849-tyabf12r 45 7 replication replication NN cord-337849-tyabf12r 45 8 strategies strategy NNS cord-337849-tyabf12r 45 9 , , , cord-337849-tyabf12r 45 10 and and CC cord-337849-tyabf12r 45 11 the the DT cord-337849-tyabf12r 45 12 types type NNS cord-337849-tyabf12r 45 13 of of IN cord-337849-tyabf12r 45 14 PRRs prr NNS cord-337849-tyabf12r 45 15 activated activate VBN cord-337849-tyabf12r 45 16 , , , cord-337849-tyabf12r 45 17 common common JJ cord-337849-tyabf12r 45 18 signalling signal VBG cord-337849-tyabf12r 45 19 pathways pathway NNS cord-337849-tyabf12r 45 20 are be VBP cord-337849-tyabf12r 45 21 utilized utilize VBN cord-337849-tyabf12r 45 22 . . . cord-337849-tyabf12r 46 1 Thus thus RB cord-337849-tyabf12r 46 2 recognition recognition NN cord-337849-tyabf12r 46 3 of of IN cord-337849-tyabf12r 46 4 viral viral JJ cord-337849-tyabf12r 46 5 pathogens pathogen NNS cord-337849-tyabf12r 46 6 elicit elicit VBP cord-337849-tyabf12r 46 7 conserved conserve VBN cord-337849-tyabf12r 46 8 outcomes outcome NNS cord-337849-tyabf12r 46 9 , , , cord-337849-tyabf12r 46 10 with with IN cord-337849-tyabf12r 46 11 the the DT cord-337849-tyabf12r 46 12 interferon interferon NN cord-337849-tyabf12r 46 13 regulatory regulatory JJ cord-337849-tyabf12r 46 14 factor factor NN cord-337849-tyabf12r 46 15 ( ( -LRB- cord-337849-tyabf12r 46 16 IRF)-mediated irf)-mediate VBN cord-337849-tyabf12r 46 17 production production NN cord-337849-tyabf12r 46 18 of of IN cord-337849-tyabf12r 46 19 type type NN cord-337849-tyabf12r 47 1 I -PRON- PRP cord-337849-tyabf12r 47 2 IFNs ifns VBP cord-337849-tyabf12r 47 3 a a DT cord-337849-tyabf12r 47 4 central central JJ cord-337849-tyabf12r 47 5 feature feature NN cord-337849-tyabf12r 47 6 , , , cord-337849-tyabf12r 47 7 along along IN cord-337849-tyabf12r 47 8 with with IN cord-337849-tyabf12r 47 9 nuclear nuclear JJ cord-337849-tyabf12r 47 10 factor factor NN cord-337849-tyabf12r 47 11 kappa kappa NN cord-337849-tyabf12r 47 12 B B NNP cord-337849-tyabf12r 47 13 ( ( -LRB- cord-337849-tyabf12r 47 14 NF NF NNP cord-337849-tyabf12r 47 15 - - HYPH cord-337849-tyabf12r 47 16 κB)-and κB)-and NNP cord-337849-tyabf12r 47 17 mitogen mitogen NN cord-337849-tyabf12r 47 18 - - HYPH cord-337849-tyabf12r 47 19 activated activate VBN cord-337849-tyabf12r 47 20 protein protein NN cord-337849-tyabf12r 47 21 kinase kinase NN cord-337849-tyabf12r 47 22 ( ( -LRB- cord-337849-tyabf12r 47 23 MAPK)-mediated MAPK)-mediated NNP cord-337849-tyabf12r 47 24 regulation regulation NN cord-337849-tyabf12r 47 25 of of IN cord-337849-tyabf12r 47 26 various various JJ cord-337849-tyabf12r 47 27 inflammatory inflammatory JJ cord-337849-tyabf12r 47 28 cytokines cytokine NNS cord-337849-tyabf12r 47 29 [ [ -LRB- cord-337849-tyabf12r 47 30 37 37 CD cord-337849-tyabf12r 47 31 , , , cord-337849-tyabf12r 47 32 45 45 CD cord-337849-tyabf12r 47 33 ] ] -RRB- cord-337849-tyabf12r 47 34 ( ( -LRB- cord-337849-tyabf12r 47 35 Figure figure NN cord-337849-tyabf12r 47 36 1 1 CD cord-337849-tyabf12r 47 37 ) ) -RRB- cord-337849-tyabf12r 47 38 . . . cord-337849-tyabf12r 48 1 Upon upon IN cord-337849-tyabf12r 48 2 PAMP PAMP NNP cord-337849-tyabf12r 48 3 - - HYPH cord-337849-tyabf12r 48 4 PRR PRR NNP cord-337849-tyabf12r 48 5 interaction interaction NN cord-337849-tyabf12r 48 6 and and CC cord-337849-tyabf12r 48 7 the the DT cord-337849-tyabf12r 48 8 activation activation NN cord-337849-tyabf12r 48 9 of of IN cord-337849-tyabf12r 48 10 signalling signal VBG cord-337849-tyabf12r 48 11 transduction transduction NN cord-337849-tyabf12r 48 12 pathways pathway NNS cord-337849-tyabf12r 48 13 , , , cord-337849-tyabf12r 48 14 the the DT cord-337849-tyabf12r 48 15 type type NN cord-337849-tyabf12r 48 16 I -PRON- PRP cord-337849-tyabf12r 48 17 IFNs ifns VBP cord-337849-tyabf12r 48 18 ( ( -LRB- cord-337849-tyabf12r 48 19 IFN IFN NNP cord-337849-tyabf12r 48 20 - - HYPH cord-337849-tyabf12r 48 21 α α NNP cord-337849-tyabf12r 48 22 and and CC cord-337849-tyabf12r 48 23 IFN IFN NNP cord-337849-tyabf12r 48 24 - - HYPH cord-337849-tyabf12r 48 25 β β NNP cord-337849-tyabf12r 48 26 ) ) -RRB- cord-337849-tyabf12r 48 27 are be VBP cord-337849-tyabf12r 48 28 some some DT cord-337849-tyabf12r 48 29 of of IN cord-337849-tyabf12r 48 30 the the DT cord-337849-tyabf12r 48 31 earliest early JJS cord-337849-tyabf12r 48 32 cytokines cytokine NNS cord-337849-tyabf12r 48 33 to to TO cord-337849-tyabf12r 48 34 be be VB cord-337849-tyabf12r 48 35 produced produce VBN cord-337849-tyabf12r 48 36 . . . cord-337849-tyabf12r 49 1 Their -PRON- PRP$ cord-337849-tyabf12r 49 2 transcription transcription NN cord-337849-tyabf12r 49 3 and and CC cord-337849-tyabf12r 49 4 subsequent subsequent JJ cord-337849-tyabf12r 49 5 binding binding NN cord-337849-tyabf12r 49 6 to to IN cord-337849-tyabf12r 49 7 the the DT cord-337849-tyabf12r 49 8 IFN IFN NNP cord-337849-tyabf12r 49 9 receptor receptor NN cord-337849-tyabf12r 49 10 induces induce VBZ cord-337849-tyabf12r 49 11 expression expression NN cord-337849-tyabf12r 49 12 of of IN cord-337849-tyabf12r 49 13 a a DT cord-337849-tyabf12r 49 14 variety variety NN cord-337849-tyabf12r 49 15 of of IN cord-337849-tyabf12r 49 16 interferon interferon NN cord-337849-tyabf12r 49 17 - - HYPH cord-337849-tyabf12r 49 18 stimulated stimulate VBN cord-337849-tyabf12r 49 19 genes gene NNS cord-337849-tyabf12r 49 20 ( ( -LRB- cord-337849-tyabf12r 49 21 ISGs ISGs NNP cord-337849-tyabf12r 49 22 ) ) -RRB- cord-337849-tyabf12r 49 23 , , , cord-337849-tyabf12r 49 24 with with IN cord-337849-tyabf12r 49 25 their -PRON- PRP$ cord-337849-tyabf12r 49 26 products product NNS cord-337849-tyabf12r 49 27 altering alter VBG cord-337849-tyabf12r 49 28 antiviral antiviral JJ cord-337849-tyabf12r 49 29 and and CC cord-337849-tyabf12r 49 30 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 49 31 actions action NNS cord-337849-tyabf12r 49 32 to to TO cord-337849-tyabf12r 49 33 limit limit VB cord-337849-tyabf12r 49 34 and and CC cord-337849-tyabf12r 49 35 clear clear JJ cord-337849-tyabf12r 49 36 infection infection NN cord-337849-tyabf12r 49 37 [ [ -LRB- cord-337849-tyabf12r 49 38 45 45 CD cord-337849-tyabf12r 49 39 ] ] -RRB- cord-337849-tyabf12r 49 40 . . . cord-337849-tyabf12r 50 1 Features feature NNS cord-337849-tyabf12r 50 2 of of IN cord-337849-tyabf12r 50 3 the the DT cord-337849-tyabf12r 50 4 induced induce VBN cord-337849-tyabf12r 50 5 anti anti JJ cord-337849-tyabf12r 50 6 - - JJ cord-337849-tyabf12r 50 7 viral viral JJ cord-337849-tyabf12r 50 8 state state NN cord-337849-tyabf12r 50 9 include include VBP cord-337849-tyabf12r 50 10 resistance resistance NN cord-337849-tyabf12r 50 11 to to IN cord-337849-tyabf12r 50 12 viral viral JJ cord-337849-tyabf12r 50 13 replication replication NN cord-337849-tyabf12r 50 14 in in IN cord-337849-tyabf12r 50 15 all all DT cord-337849-tyabf12r 50 16 cells cell NNS cord-337849-tyabf12r 50 17 , , , cord-337849-tyabf12r 50 18 induction induction NN cord-337849-tyabf12r 50 19 of of IN cord-337849-tyabf12r 50 20 apoptotic apoptotic JJ cord-337849-tyabf12r 50 21 cell cell NN cord-337849-tyabf12r 50 22 death death NN cord-337849-tyabf12r 50 23 in in IN cord-337849-tyabf12r 50 24 infected infected JJ cord-337849-tyabf12r 50 25 cells cell NNS cord-337849-tyabf12r 50 26 , , , cord-337849-tyabf12r 50 27 increased increase VBN cord-337849-tyabf12r 50 28 major major JJ cord-337849-tyabf12r 50 29 histocompatibility histocompatibility NN cord-337849-tyabf12r 50 30 complex complex NN cord-337849-tyabf12r 51 1 ( ( -LRB- cord-337849-tyabf12r 51 2 MHC MHC NNP cord-337849-tyabf12r 51 3 ) ) -RRB- cord-337849-tyabf12r 51 4 class class NN cord-337849-tyabf12r 51 5 I -PRON- PRP cord-337849-tyabf12r 51 6 expression expression NN cord-337849-tyabf12r 51 7 to to TO cord-337849-tyabf12r 51 8 enhance enhance VB cord-337849-tyabf12r 51 9 antigen antigen NN cord-337849-tyabf12r 51 10 presentation presentation NN cord-337849-tyabf12r 51 11 , , , cord-337849-tyabf12r 51 12 activation activation NN cord-337849-tyabf12r 51 13 of of IN cord-337849-tyabf12r 51 14 dendritic dendritic JJ cord-337849-tyabf12r 51 15 cells cell NNS cord-337849-tyabf12r 51 16 ( ( -LRB- cord-337849-tyabf12r 51 17 DCs DCs NNP cord-337849-tyabf12r 51 18 ) ) -RRB- cord-337849-tyabf12r 51 19 and and CC cord-337849-tyabf12r 51 20 macrophages macrophage NNS cord-337849-tyabf12r 51 21 , , , cord-337849-tyabf12r 51 22 and and CC cord-337849-tyabf12r 51 23 stimulation stimulation NN cord-337849-tyabf12r 51 24 of of IN cord-337849-tyabf12r 51 25 natural natural JJ cord-337849-tyabf12r 51 26 killer killer NN cord-337849-tyabf12r 51 27 ( ( -LRB- cord-337849-tyabf12r 51 28 NK NK NNP cord-337849-tyabf12r 51 29 ) ) -RRB- cord-337849-tyabf12r 51 30 cells cell NNS cord-337849-tyabf12r 51 31 to to TO cord-337849-tyabf12r 51 32 enhance enhance VB cord-337849-tyabf12r 51 33 their -PRON- PRP$ cord-337849-tyabf12r 51 34 cytolytic cytolytic JJ cord-337849-tyabf12r 51 35 activity activity NN cord-337849-tyabf12r 51 36 [ [ -LRB- cord-337849-tyabf12r 51 37 46 46 CD cord-337849-tyabf12r 51 38 ] ] -RRB- cord-337849-tyabf12r 51 39 . . . cord-337849-tyabf12r 52 1 The the DT cord-337849-tyabf12r 52 2 inflammatory inflammatory JJ cord-337849-tyabf12r 52 3 cytokines cytokine NNS cord-337849-tyabf12r 52 4 TNF TNF NNP cord-337849-tyabf12r 52 5 - - HYPH cord-337849-tyabf12r 52 6 α α NNP cord-337849-tyabf12r 52 7 , , , cord-337849-tyabf12r 52 8 IL-1β IL-1β NNP cord-337849-tyabf12r 52 9 , , , cord-337849-tyabf12r 52 10 IL-6 IL-6 NNP cord-337849-tyabf12r 52 11 and and CC cord-337849-tyabf12r 52 12 IL-12 IL-12 NNP cord-337849-tyabf12r 52 13 are be VBP cord-337849-tyabf12r 52 14 also also RB cord-337849-tyabf12r 52 15 produced produce VBN cord-337849-tyabf12r 52 16 at at IN cord-337849-tyabf12r 52 17 an an DT cord-337849-tyabf12r 52 18 early early JJ cord-337849-tyabf12r 52 19 stage stage NN cord-337849-tyabf12r 52 20 of of IN cord-337849-tyabf12r 52 21 the the DT cord-337849-tyabf12r 52 22 innate innate JJ cord-337849-tyabf12r 52 23 immune immune JJ cord-337849-tyabf12r 52 24 response response NN cord-337849-tyabf12r 52 25 . . . cord-337849-tyabf12r 53 1 These these DT cord-337849-tyabf12r 53 2 cytokines cytokine NNS cord-337849-tyabf12r 53 3 promote promote VBP cord-337849-tyabf12r 53 4 leukocyte leukocyte NN cord-337849-tyabf12r 53 5 extravasation extravasation NN cord-337849-tyabf12r 53 6 by by IN cord-337849-tyabf12r 53 7 increasing increase VBG cord-337849-tyabf12r 53 8 endothelial endothelial JJ cord-337849-tyabf12r 53 9 expression expression NN cord-337849-tyabf12r 53 10 of of IN cord-337849-tyabf12r 53 11 adhesion adhesion NN cord-337849-tyabf12r 53 12 molecules molecule NNS cord-337849-tyabf12r 53 13 , , , cord-337849-tyabf12r 53 14 such such JJ cord-337849-tyabf12r 53 15 as as IN cord-337849-tyabf12r 53 16 ICAM-1 ICAM-1 NNP cord-337849-tyabf12r 53 17 and and CC cord-337849-tyabf12r 53 18 VCAM-1 VCAM-1 NNP cord-337849-tyabf12r 53 19 , , , cord-337849-tyabf12r 53 20 increase increase VB cord-337849-tyabf12r 53 21 vascular vascular JJ cord-337849-tyabf12r 53 22 permeability permeability NN cord-337849-tyabf12r 53 23 , , , cord-337849-tyabf12r 53 24 induce induce VB cord-337849-tyabf12r 53 25 synthesis synthesis NN cord-337849-tyabf12r 53 26 of of IN cord-337849-tyabf12r 53 27 acute acute JJ cord-337849-tyabf12r 53 28 phase phase NN cord-337849-tyabf12r 53 29 proteins protein NNS cord-337849-tyabf12r 53 30 , , , cord-337849-tyabf12r 53 31 and and CC cord-337849-tyabf12r 53 32 contribute contribute VB cord-337849-tyabf12r 53 33 to to IN cord-337849-tyabf12r 53 34 recruitment recruitment NN cord-337849-tyabf12r 53 35 and and CC cord-337849-tyabf12r 53 36 activation activation NN cord-337849-tyabf12r 53 37 of of IN cord-337849-tyabf12r 53 38 cells cell NNS cord-337849-tyabf12r 53 39 of of IN cord-337849-tyabf12r 53 40 the the DT cord-337849-tyabf12r 53 41 adaptive adaptive JJ cord-337849-tyabf12r 53 42 immune immune JJ cord-337849-tyabf12r 53 43 response response NN cord-337849-tyabf12r 53 44 . . . cord-337849-tyabf12r 54 1 Additionally additionally RB cord-337849-tyabf12r 54 2 , , , cord-337849-tyabf12r 54 3 IL-1β IL-1β NNP cord-337849-tyabf12r 54 4 and and CC cord-337849-tyabf12r 54 5 TNF TNF NNP cord-337849-tyabf12r 54 6 - - HYPH cord-337849-tyabf12r 54 7 α α NN cord-337849-tyabf12r 54 8 amplify amplify VBP cord-337849-tyabf12r 54 9 the the DT cord-337849-tyabf12r 54 10 inflammatory inflammatory JJ cord-337849-tyabf12r 54 11 response response NN cord-337849-tyabf12r 54 12 by by IN cord-337849-tyabf12r 54 13 triggering trigger VBG cord-337849-tyabf12r 54 14 further further JJ cord-337849-tyabf12r 54 15 NF nf NN cord-337849-tyabf12r 54 16 - - HYPH cord-337849-tyabf12r 54 17 κB κB NNP cord-337849-tyabf12r 54 18 and and CC cord-337849-tyabf12r 54 19 MAPK MAPK NNP cord-337849-tyabf12r 54 20 activation activation NN cord-337849-tyabf12r 54 21 [ [ -LRB- cord-337849-tyabf12r 54 22 47 47 CD cord-337849-tyabf12r 54 23 ] ] -RRB- cord-337849-tyabf12r 54 24 . . . cord-337849-tyabf12r 55 1 Pathogen pathogen NN cord-337849-tyabf12r 55 2 recognition recognition NN cord-337849-tyabf12r 55 3 receptor receptor NN cord-337849-tyabf12r 55 4 signalling signal VBG cord-337849-tyabf12r 55 5 following follow VBG cord-337849-tyabf12r 55 6 viral viral JJ cord-337849-tyabf12r 55 7 infection infection NN cord-337849-tyabf12r 55 8 . . . cord-337849-tyabf12r 56 1 Ligand ligand NN cord-337849-tyabf12r 56 2 - - HYPH cord-337849-tyabf12r 56 3 induced induce VBN cord-337849-tyabf12r 56 4 dimerisation dimerisation NN cord-337849-tyabf12r 56 5 occurs occur VBZ cord-337849-tyabf12r 56 6 following follow VBG cord-337849-tyabf12r 56 7 PAMP PAMP NNP cord-337849-tyabf12r 56 8 recognition recognition NN cord-337849-tyabf12r 56 9 by by IN cord-337849-tyabf12r 56 10 endosomal endosomal NNP cord-337849-tyabf12r 56 11 TLRs TLRs NNP cord-337849-tyabf12r 56 12 , , , cord-337849-tyabf12r 56 13 which which WDT cord-337849-tyabf12r 56 14 engages engage VBZ cord-337849-tyabf12r 56 15 the the DT cord-337849-tyabf12r 56 16 Toll Toll NNP cord-337849-tyabf12r 56 17 - - HYPH cord-337849-tyabf12r 56 18 IL-1 IL-1 NNP cord-337849-tyabf12r 56 19 receptor receptor NN cord-337849-tyabf12r 56 20 ( ( -LRB- cord-337849-tyabf12r 56 21 TIR TIR NNP cord-337849-tyabf12r 56 22 ) ) -RRB- cord-337849-tyabf12r 56 23 domains domain NNS cord-337849-tyabf12r 56 24 to to TO cord-337849-tyabf12r 56 25 initiate initiate VB cord-337849-tyabf12r 56 26 adaptor adaptor NN cord-337849-tyabf12r 56 27 molecule molecule NN cord-337849-tyabf12r 56 28 recruitment recruitment NN cord-337849-tyabf12r 56 29 and and CC cord-337849-tyabf12r 56 30 signal signal NN cord-337849-tyabf12r 56 31 transduction transduction NN cord-337849-tyabf12r 56 32 . . . cord-337849-tyabf12r 57 1 MYD88-dependent myd88-dependent DT cord-337849-tyabf12r 57 2 signalling signal VBG cord-337849-tyabf12r 57 3 results result NNS cord-337849-tyabf12r 57 4 in in IN cord-337849-tyabf12r 57 5 the the DT cord-337849-tyabf12r 57 6 formation formation NN cord-337849-tyabf12r 57 7 of of IN cord-337849-tyabf12r 57 8 an an DT cord-337849-tyabf12r 57 9 IRAK IRAK NNP cord-337849-tyabf12r 57 10 / / SYM cord-337849-tyabf12r 57 11 TRAF6 traf6 NN cord-337849-tyabf12r 57 12 complex complex NN cord-337849-tyabf12r 57 13 , , , cord-337849-tyabf12r 57 14 which which WDT cord-337849-tyabf12r 57 15 phosphorylates phosphorylate VBZ cord-337849-tyabf12r 57 16 IRF7 IRF7 NNP cord-337849-tyabf12r 57 17 to to TO cord-337849-tyabf12r 57 18 initiate initiate VB cord-337849-tyabf12r 57 19 transcription transcription NN cord-337849-tyabf12r 57 20 of of IN cord-337849-tyabf12r 57 21 type type NN cord-337849-tyabf12r 57 22 I -PRON- PRP cord-337849-tyabf12r 57 23 IFN IFN NNP cord-337849-tyabf12r 57 24 genes gene NNS cord-337849-tyabf12r 57 25 , , , cord-337849-tyabf12r 57 26 and and CC cord-337849-tyabf12r 57 27 activates activate VBZ cord-337849-tyabf12r 57 28 a a DT cord-337849-tyabf12r 57 29 TAK1 TAK1 NNP cord-337849-tyabf12r 57 30 / / SYM cord-337849-tyabf12r 57 31 TAB2/3 TAB2/3 NNP cord-337849-tyabf12r 57 32 complex complex NN cord-337849-tyabf12r 57 33 to to TO cord-337849-tyabf12r 57 34 drive drive VB cord-337849-tyabf12r 57 35 transcription transcription NN cord-337849-tyabf12r 57 36 of of IN cord-337849-tyabf12r 57 37 pro pro JJ cord-337849-tyabf12r 57 38 - - JJ cord-337849-tyabf12r 57 39 inflammatory inflammatory JJ cord-337849-tyabf12r 57 40 cytokine cytokine NN cord-337849-tyabf12r 57 41 genes gene NNS cord-337849-tyabf12r 57 42 via via IN cord-337849-tyabf12r 57 43 activation activation NN cord-337849-tyabf12r 57 44 of of IN cord-337849-tyabf12r 57 45 NF nf NN cord-337849-tyabf12r 57 46 - - HYPH cord-337849-tyabf12r 57 47 κB κB NNP cord-337849-tyabf12r 57 48 , , , cord-337849-tyabf12r 57 49 AP1 AP1 NNP cord-337849-tyabf12r 57 50 and and CC cord-337849-tyabf12r 57 51 CREB CREB NNP cord-337849-tyabf12r 57 52 . . . cord-337849-tyabf12r 58 1 TRIF trif NN cord-337849-tyabf12r 58 2 - - HYPH cord-337849-tyabf12r 58 3 dependent dependent JJ cord-337849-tyabf12r 58 4 signalling signalling NN cord-337849-tyabf12r 58 5 can can MD cord-337849-tyabf12r 58 6 also also RB cord-337849-tyabf12r 58 7 activate activate VB cord-337849-tyabf12r 58 8 NF NF NNP cord-337849-tyabf12r 58 9 - - HYPH cord-337849-tyabf12r 58 10 κB κB NNP cord-337849-tyabf12r 58 11 , , , cord-337849-tyabf12r 58 12 AP-1 AP-1 NNP cord-337849-tyabf12r 58 13 and and CC cord-337849-tyabf12r 58 14 CREB CREB NNP cord-337849-tyabf12r 58 15 via via IN cord-337849-tyabf12r 58 16 recruitment recruitment NNP cord-337849-tyabf12r 58 17 of of IN cord-337849-tyabf12r 58 18 TRAF6 TRAF6 NNP cord-337849-tyabf12r 58 19 and and CC cord-337849-tyabf12r 58 20 RIP1 RIP1 NNP cord-337849-tyabf12r 58 21 . . . cord-337849-tyabf12r 59 1 Alternatively alternatively RB cord-337849-tyabf12r 59 2 , , , cord-337849-tyabf12r 59 3 TRAF3 TRAF3 NNP cord-337849-tyabf12r 59 4 is be VBZ cord-337849-tyabf12r 59 5 recruited recruit VBN cord-337849-tyabf12r 59 6 , , , cord-337849-tyabf12r 59 7 resulting result VBG cord-337849-tyabf12r 59 8 in in IN cord-337849-tyabf12r 59 9 phosphorylation phosphorylation NN cord-337849-tyabf12r 59 10 of of IN cord-337849-tyabf12r 59 11 IRF3 IRF3 NNP cord-337849-tyabf12r 59 12 which which WDT cord-337849-tyabf12r 59 13 translocates translocate VBZ cord-337849-tyabf12r 59 14 into into IN cord-337849-tyabf12r 59 15 the the DT cord-337849-tyabf12r 59 16 nucleus nucleus NN cord-337849-tyabf12r 59 17 to to TO cord-337849-tyabf12r 59 18 induce induce VB cord-337849-tyabf12r 59 19 expression expression NN cord-337849-tyabf12r 59 20 of of IN cord-337849-tyabf12r 59 21 type type NN cord-337849-tyabf12r 59 22 I -PRON- PRP cord-337849-tyabf12r 59 23 IFNs ifns VBP cord-337849-tyabf12r 59 24 . . . cord-337849-tyabf12r 60 1 RIG rig NN cord-337849-tyabf12r 60 2 - - : cord-337849-tyabf12r 60 3 I I NNP cord-337849-tyabf12r 60 4 and and CC cord-337849-tyabf12r 60 5 MDA5 MDA5 NNP cord-337849-tyabf12r 60 6 are be VBP cord-337849-tyabf12r 60 7 also also RB cord-337849-tyabf12r 60 8 able able JJ cord-337849-tyabf12r 60 9 to to TO cord-337849-tyabf12r 60 10 activate activate VB cord-337849-tyabf12r 60 11 NF NF NNP cord-337849-tyabf12r 60 12 - - HYPH cord-337849-tyabf12r 60 13 κB κB NNP cord-337849-tyabf12r 60 14 and and CC cord-337849-tyabf12r 60 15 IRF3 IRF3 NNP cord-337849-tyabf12r 60 16 via via IN cord-337849-tyabf12r 60 17 interaction interaction NN cord-337849-tyabf12r 60 18 with with IN cord-337849-tyabf12r 60 19 IPS-1 IPS-1 NNP cord-337849-tyabf12r 61 1 localized localize VBN cord-337849-tyabf12r 61 2 on on IN cord-337849-tyabf12r 61 3 the the DT cord-337849-tyabf12r 61 4 mitochondrial mitochondrial JJ cord-337849-tyabf12r 61 5 membrane membrane NN cord-337849-tyabf12r 61 6 through through IN cord-337849-tyabf12r 61 7 homophilic homophilic JJ cord-337849-tyabf12r 61 8 interactions interaction NNS cord-337849-tyabf12r 61 9 between between IN cord-337849-tyabf12r 61 10 their -PRON- PRP$ cord-337849-tyabf12r 61 11 CARD card NN cord-337849-tyabf12r 61 12 domains domain NNS cord-337849-tyabf12r 61 13 . . . cord-337849-tyabf12r 62 1 Similarly similarly RB cord-337849-tyabf12r 62 2 , , , cord-337849-tyabf12r 62 3 CARD card NN cord-337849-tyabf12r 62 4 domains domain NNS cord-337849-tyabf12r 62 5 of of IN cord-337849-tyabf12r 62 6 NOD2 NOD2 NNPS cord-337849-tyabf12r 62 7 also also RB cord-337849-tyabf12r 62 8 interact interact VBP cord-337849-tyabf12r 62 9 with with IN cord-337849-tyabf12r 62 10 IPS-1 IPS-1 NNP cord-337849-tyabf12r 62 11 resulting result VBG cord-337849-tyabf12r 62 12 in in IN cord-337849-tyabf12r 62 13 transcription transcription NN cord-337849-tyabf12r 62 14 of of IN cord-337849-tyabf12r 62 15 type type NN cord-337849-tyabf12r 62 16 I -PRON- PRP cord-337849-tyabf12r 62 17 IFN IFN NNP cord-337849-tyabf12r 62 18 genes gene NNS cord-337849-tyabf12r 62 19 . . . cord-337849-tyabf12r 63 1 The the DT cord-337849-tyabf12r 63 2 type type NN cord-337849-tyabf12r 63 3 I -PRON- PRP cord-337849-tyabf12r 63 4 IFNs ifns VBP cord-337849-tyabf12r 63 5 produced produce VBN cord-337849-tyabf12r 63 6 bind bind NN cord-337849-tyabf12r 63 7 to to IN cord-337849-tyabf12r 63 8 their -PRON- PRP$ cord-337849-tyabf12r 63 9 receptor receptor NN cord-337849-tyabf12r 63 10 , , , cord-337849-tyabf12r 63 11 and and CC cord-337849-tyabf12r 63 12 , , , cord-337849-tyabf12r 63 13 via via IN cord-337849-tyabf12r 63 14 STAT stat NN cord-337849-tyabf12r 63 15 - - HYPH cord-337849-tyabf12r 63 16 mediating mediate VBG cord-337849-tyabf12r 63 17 signalling signalling NN cord-337849-tyabf12r 63 18 , , , cord-337849-tyabf12r 63 19 initiate initiate VB cord-337849-tyabf12r 63 20 gene gene NN cord-337849-tyabf12r 63 21 transcription transcription NN cord-337849-tyabf12r 63 22 . . . cord-337849-tyabf12r 64 1 Innate innate JJ cord-337849-tyabf12r 64 2 PRR PRR NNP cord-337849-tyabf12r 64 3 signalling signal VBG cord-337849-tyabf12r 64 4 also also RB cord-337849-tyabf12r 64 5 results result VBZ cord-337849-tyabf12r 64 6 in in IN cord-337849-tyabf12r 64 7 the the DT cord-337849-tyabf12r 64 8 production production NN cord-337849-tyabf12r 64 9 of of IN cord-337849-tyabf12r 64 10 the the DT cord-337849-tyabf12r 64 11 chemokines chemokine NNS cord-337849-tyabf12r 64 12 CXCL8 cxcl8 NN cord-337849-tyabf12r 64 13 , , , cord-337849-tyabf12r 64 14 CXCL9 CXCL9 NNP cord-337849-tyabf12r 64 15 , , , cord-337849-tyabf12r 64 16 CXCL10 CXCL10 NNP cord-337849-tyabf12r 64 17 and and CC cord-337849-tyabf12r 64 18 IL-15 IL-15 NNP cord-337849-tyabf12r 64 19 which which WDT cord-337849-tyabf12r 64 20 facilitate facilitate VBP cord-337849-tyabf12r 64 21 recruitment recruitment NN cord-337849-tyabf12r 64 22 of of IN cord-337849-tyabf12r 64 23 neutrophils neutrophil NNS cord-337849-tyabf12r 64 24 and and CC cord-337849-tyabf12r 64 25 NK NK NNP cord-337849-tyabf12r 64 26 cells cell NNS cord-337849-tyabf12r 64 27 , , , cord-337849-tyabf12r 64 28 respectively respectively RB cord-337849-tyabf12r 64 29 [ [ -LRB- cord-337849-tyabf12r 64 30 48 48 CD cord-337849-tyabf12r 64 31 , , , cord-337849-tyabf12r 64 32 49 49 CD cord-337849-tyabf12r 64 33 ] ] -RRB- cord-337849-tyabf12r 64 34 . . . cord-337849-tyabf12r 65 1 While while IN cord-337849-tyabf12r 65 2 neutrophils neutrophil NNS cord-337849-tyabf12r 65 3 and and CC cord-337849-tyabf12r 65 4 macrophages macrophage NNS cord-337849-tyabf12r 65 5 have have VBP cord-337849-tyabf12r 65 6 well well RB cord-337849-tyabf12r 65 7 - - HYPH cord-337849-tyabf12r 65 8 defined define VBN cord-337849-tyabf12r 65 9 roles role NNS cord-337849-tyabf12r 65 10 in in IN cord-337849-tyabf12r 65 11 bacterial bacterial JJ cord-337849-tyabf12r 65 12 innate innate JJ cord-337849-tyabf12r 65 13 immunity immunity NN cord-337849-tyabf12r 65 14 , , , cord-337849-tyabf12r 65 15 their -PRON- PRP$ cord-337849-tyabf12r 65 16 function function NN cord-337849-tyabf12r 65 17 in in IN cord-337849-tyabf12r 65 18 antiviral antiviral JJ cord-337849-tyabf12r 65 19 immunity immunity NN cord-337849-tyabf12r 65 20 is be VBZ cord-337849-tyabf12r 65 21 less less RBR cord-337849-tyabf12r 65 22 clear clear JJ cord-337849-tyabf12r 65 23 and and CC cord-337849-tyabf12r 65 24 is be VBZ cord-337849-tyabf12r 65 25 likely likely JJ cord-337849-tyabf12r 65 26 to to TO cord-337849-tyabf12r 65 27 be be VB cord-337849-tyabf12r 65 28 minimal minimal JJ cord-337849-tyabf12r 65 29 , , , cord-337849-tyabf12r 65 30 with with IN cord-337849-tyabf12r 65 31 inhibition inhibition NN cord-337849-tyabf12r 65 32 of of IN cord-337849-tyabf12r 65 33 neutrophil neutrophil NN cord-337849-tyabf12r 65 34 recruitment recruitment NN cord-337849-tyabf12r 65 35 to to IN cord-337849-tyabf12r 65 36 the the DT cord-337849-tyabf12r 65 37 lung lung NN cord-337849-tyabf12r 65 38 demonstrated demonstrate VBD cord-337849-tyabf12r 65 39 to to TO cord-337849-tyabf12r 65 40 have have VB cord-337849-tyabf12r 65 41 no no DT cord-337849-tyabf12r 65 42 effect effect NN cord-337849-tyabf12r 65 43 on on IN cord-337849-tyabf12r 65 44 the the DT cord-337849-tyabf12r 65 45 course course NN cord-337849-tyabf12r 65 46 of of IN cord-337849-tyabf12r 65 47 influenza influenza NN cord-337849-tyabf12r 65 48 infection infection NN cord-337849-tyabf12r 65 49 [ [ -LRB- cord-337849-tyabf12r 65 50 50 50 CD cord-337849-tyabf12r 65 51 ] ] -RRB- cord-337849-tyabf12r 65 52 , , , cord-337849-tyabf12r 65 53 and and CC cord-337849-tyabf12r 65 54 the the DT cord-337849-tyabf12r 65 55 antigen antigen NN cord-337849-tyabf12r 65 56 presenting present VBG cord-337849-tyabf12r 65 57 capacity capacity NN cord-337849-tyabf12r 65 58 of of IN cord-337849-tyabf12r 65 59 macrophages macrophage NNS cord-337849-tyabf12r 65 60 in in IN cord-337849-tyabf12r 65 61 the the DT cord-337849-tyabf12r 65 62 respiratory respiratory JJ cord-337849-tyabf12r 65 63 tract tract NN cord-337849-tyabf12r 65 64 demonstrated demonstrate VBD cord-337849-tyabf12r 65 65 to to TO cord-337849-tyabf12r 65 66 be be VB cord-337849-tyabf12r 65 67 limited limit VBN cord-337849-tyabf12r 65 68 [ [ -LRB- cord-337849-tyabf12r 65 69 51 51 CD cord-337849-tyabf12r 65 70 , , , cord-337849-tyabf12r 65 71 52 52 CD cord-337849-tyabf12r 65 72 ] ] -RRB- cord-337849-tyabf12r 65 73 . . . cord-337849-tyabf12r 66 1 The the DT cord-337849-tyabf12r 66 2 antimicrobial antimicrobial JJ cord-337849-tyabf12r 66 3 peptide peptide NN cord-337849-tyabf12r 66 4 LL-37 LL-37 NNP cord-337849-tyabf12r 66 5 , , , cord-337849-tyabf12r 66 6 which which WDT cord-337849-tyabf12r 66 7 is be VBZ cord-337849-tyabf12r 66 8 produced produce VBN cord-337849-tyabf12r 66 9 by by IN cord-337849-tyabf12r 66 10 both both DT cord-337849-tyabf12r 66 11 neutrophils neutrophil NNS cord-337849-tyabf12r 66 12 and and CC cord-337849-tyabf12r 66 13 macrophages macrophage NNS cord-337849-tyabf12r 66 14 , , , cord-337849-tyabf12r 66 15 is be VBZ cord-337849-tyabf12r 66 16 traditionally traditionally RB cord-337849-tyabf12r 66 17 viewed view VBN cord-337849-tyabf12r 66 18 as as IN cord-337849-tyabf12r 66 19 a a DT cord-337849-tyabf12r 66 20 component component NN cord-337849-tyabf12r 66 21 of of IN cord-337849-tyabf12r 66 22 the the DT cord-337849-tyabf12r 66 23 immune immune JJ cord-337849-tyabf12r 66 24 response response NN cord-337849-tyabf12r 66 25 to to IN cord-337849-tyabf12r 66 26 bacteria bacteria NNS cord-337849-tyabf12r 66 27 . . . cord-337849-tyabf12r 67 1 However however RB cord-337849-tyabf12r 67 2 , , , cord-337849-tyabf12r 67 3 anti anti JJ cord-337849-tyabf12r 67 4 - - JJ cord-337849-tyabf12r 67 5 viral viral JJ cord-337849-tyabf12r 67 6 activity activity NN cord-337849-tyabf12r 67 7 of of IN cord-337849-tyabf12r 67 8 LL-37 LL-37 NNP cord-337849-tyabf12r 67 9 has have VBZ cord-337849-tyabf12r 67 10 also also RB cord-337849-tyabf12r 67 11 been be VBN cord-337849-tyabf12r 67 12 demonstrated demonstrate VBN cord-337849-tyabf12r 67 13 against against IN cord-337849-tyabf12r 67 14 both both CC cord-337849-tyabf12r 67 15 enveloped envelop VBN cord-337849-tyabf12r 67 16 and and CC cord-337849-tyabf12r 67 17 non non JJ cord-337849-tyabf12r 67 18 - - JJ cord-337849-tyabf12r 67 19 enveloped enveloped JJ cord-337849-tyabf12r 67 20 viruses virus NNS cord-337849-tyabf12r 67 21 , , , cord-337849-tyabf12r 67 22 including include VBG cord-337849-tyabf12r 67 23 influenza influenza NN cord-337849-tyabf12r 67 24 virus virus NN cord-337849-tyabf12r 67 25 and and CC cord-337849-tyabf12r 67 26 RSV RSV NNP cord-337849-tyabf12r 67 27 [ [ -LRB- cord-337849-tyabf12r 67 28 53 53 CD cord-337849-tyabf12r 67 29 ] ] -RRB- cord-337849-tyabf12r 67 30 . . . cord-337849-tyabf12r 68 1 It -PRON- PRP cord-337849-tyabf12r 68 2 has have VBZ cord-337849-tyabf12r 68 3 been be VBN cord-337849-tyabf12r 68 4 shown show VBN cord-337849-tyabf12r 68 5 to to TO cord-337849-tyabf12r 68 6 disrupt disrupt VB cord-337849-tyabf12r 68 7 the the DT cord-337849-tyabf12r 68 8 membrane membrane NN cord-337849-tyabf12r 68 9 of of IN cord-337849-tyabf12r 68 10 influenza influenza NN cord-337849-tyabf12r 68 11 virus virus NN cord-337849-tyabf12r 68 12 [ [ -LRB- cord-337849-tyabf12r 68 13 54 54 CD cord-337849-tyabf12r 68 14 ] ] -RRB- cord-337849-tyabf12r 68 15 , , , cord-337849-tyabf12r 68 16 modify modify VB cord-337849-tyabf12r 68 17 cytokine cytokine NN cord-337849-tyabf12r 68 18 production production NN cord-337849-tyabf12r 68 19 [ [ -LRB- cord-337849-tyabf12r 68 20 54 54 CD cord-337849-tyabf12r 68 21 ] ] -RRB- cord-337849-tyabf12r 68 22 , , , cord-337849-tyabf12r 68 23 enhance enhance VB cord-337849-tyabf12r 68 24 TLR3 TLR3 NNP cord-337849-tyabf12r 68 25 signalling signal VBG cord-337849-tyabf12r 68 26 [ [ -LRB- cord-337849-tyabf12r 68 27 55 55 CD cord-337849-tyabf12r 68 28 ] ] -RRB- cord-337849-tyabf12r 68 29 , , , cord-337849-tyabf12r 68 30 and and CC cord-337849-tyabf12r 68 31 have have VB cord-337849-tyabf12r 68 32 direct direct JJ cord-337849-tyabf12r 68 33 effects effect NNS cord-337849-tyabf12r 68 34 on on IN cord-337849-tyabf12r 68 35 RSV RSV NNP cord-337849-tyabf12r 68 36 viral viral JJ cord-337849-tyabf12r 68 37 particles particle NNS cord-337849-tyabf12r 68 38 and and CC cord-337849-tyabf12r 68 39 infected infected JJ cord-337849-tyabf12r 68 40 epithelial epithelial JJ cord-337849-tyabf12r 68 41 cells cell NNS cord-337849-tyabf12r 68 42 , , , cord-337849-tyabf12r 68 43 with with IN cord-337849-tyabf12r 68 44 diminished diminished JJ cord-337849-tyabf12r 68 45 spread spread NN cord-337849-tyabf12r 68 46 of of IN cord-337849-tyabf12r 68 47 infection infection NN cord-337849-tyabf12r 68 48 and and CC cord-337849-tyabf12r 68 49 inhibited inhibited JJ cord-337849-tyabf12r 68 50 production production NN cord-337849-tyabf12r 68 51 of of IN cord-337849-tyabf12r 68 52 new new JJ cord-337849-tyabf12r 68 53 virus virus NN cord-337849-tyabf12r 68 54 particles particle NNS cord-337849-tyabf12r 68 55 [ [ -LRB- cord-337849-tyabf12r 68 56 56 56 CD cord-337849-tyabf12r 68 57 ] ] -RRB- cord-337849-tyabf12r 68 58 . . . cord-337849-tyabf12r 69 1 Macrophages macrophage NNS cord-337849-tyabf12r 69 2 may may MD cord-337849-tyabf12r 69 3 also also RB cord-337849-tyabf12r 69 4 have have VB cord-337849-tyabf12r 69 5 a a DT cord-337849-tyabf12r 69 6 critical critical JJ cord-337849-tyabf12r 69 7 role role NN cord-337849-tyabf12r 69 8 in in IN cord-337849-tyabf12r 69 9 the the DT cord-337849-tyabf12r 69 10 resolution resolution NN cord-337849-tyabf12r 69 11 of of IN cord-337849-tyabf12r 69 12 inflammation inflammation NN cord-337849-tyabf12r 69 13 and and CC cord-337849-tyabf12r 69 14 clearance clearance NN cord-337849-tyabf12r 69 15 of of IN cord-337849-tyabf12r 69 16 infection infection NN cord-337849-tyabf12r 69 17 to to TO cord-337849-tyabf12r 69 18 prevent prevent VB cord-337849-tyabf12r 69 19 immunopathology immunopathology NN cord-337849-tyabf12r 69 20 . . . cord-337849-tyabf12r 70 1 They -PRON- PRP cord-337849-tyabf12r 70 2 are be VBP cord-337849-tyabf12r 70 3 able able JJ cord-337849-tyabf12r 70 4 to to TO cord-337849-tyabf12r 70 5 phagocytose phagocytose VB cord-337849-tyabf12r 70 6 infected infected JJ cord-337849-tyabf12r 70 7 cells cell NNS cord-337849-tyabf12r 70 8 and and CC cord-337849-tyabf12r 70 9 apoptotic apoptotic JJ cord-337849-tyabf12r 70 10 cellular cellular JJ cord-337849-tyabf12r 70 11 debris debris NN cord-337849-tyabf12r 70 12 , , , cord-337849-tyabf12r 70 13 which which WDT cord-337849-tyabf12r 70 14 , , , cord-337849-tyabf12r 70 15 if if IN cord-337849-tyabf12r 70 16 left leave VBN cord-337849-tyabf12r 70 17 in in IN cord-337849-tyabf12r 70 18 the the DT cord-337849-tyabf12r 70 19 lumen lumen NN cord-337849-tyabf12r 70 20 , , , cord-337849-tyabf12r 70 21 can can MD cord-337849-tyabf12r 70 22 release release VB cord-337849-tyabf12r 70 23 chemokines chemokine NNS cord-337849-tyabf12r 70 24 , , , cord-337849-tyabf12r 70 25 such such JJ cord-337849-tyabf12r 70 26 as as IN cord-337849-tyabf12r 70 27 CXCL9 CXCL9 NNP cord-337849-tyabf12r 70 28 and and CC cord-337849-tyabf12r 70 29 CXCL10 CXCL10 NNP cord-337849-tyabf12r 70 30 , , , cord-337849-tyabf12r 70 31 resulting result VBG cord-337849-tyabf12r 70 32 in in IN cord-337849-tyabf12r 70 33 recruitment recruitment NN cord-337849-tyabf12r 70 34 of of IN cord-337849-tyabf12r 70 35 inflammatory inflammatory JJ cord-337849-tyabf12r 70 36 cells cell NNS cord-337849-tyabf12r 70 37 and and CC cord-337849-tyabf12r 70 38 increased increase VBN cord-337849-tyabf12r 70 39 bystander bystander NN cord-337849-tyabf12r 70 40 tissue tissue NN cord-337849-tyabf12r 70 41 damage damage NN cord-337849-tyabf12r 70 42 . . . cord-337849-tyabf12r 71 1 In in IN cord-337849-tyabf12r 71 2 the the DT cord-337849-tyabf12r 71 3 absence absence NN cord-337849-tyabf12r 71 4 of of IN cord-337849-tyabf12r 71 5 alveolar alveolar JJ cord-337849-tyabf12r 71 6 macrophages macrophage NNS cord-337849-tyabf12r 71 7 , , , cord-337849-tyabf12r 71 8 or or CC cord-337849-tyabf12r 71 9 when when WRB cord-337849-tyabf12r 71 10 macrophages macrophage NNS cord-337849-tyabf12r 71 11 have have VBP cord-337849-tyabf12r 71 12 impaired impair VBN cord-337849-tyabf12r 71 13 function function NN cord-337849-tyabf12r 71 14 , , , cord-337849-tyabf12r 71 15 airway airway NN cord-337849-tyabf12r 71 16 occlusion occlusion NN cord-337849-tyabf12r 71 17 can can MD cord-337849-tyabf12r 71 18 occur occur VB cord-337849-tyabf12r 71 19 following follow VBG cord-337849-tyabf12r 71 20 RSV RSV NNP cord-337849-tyabf12r 71 21 infection infection NN cord-337849-tyabf12r 71 22 due due IN cord-337849-tyabf12r 71 23 to to IN cord-337849-tyabf12r 71 24 the the DT cord-337849-tyabf12r 71 25 accumulation accumulation NN cord-337849-tyabf12r 71 26 of of IN cord-337849-tyabf12r 71 27 inflammatory inflammatory JJ cord-337849-tyabf12r 71 28 cells cell NNS cord-337849-tyabf12r 71 29 , , , cord-337849-tyabf12r 71 30 virus virus NN cord-337849-tyabf12r 71 31 - - HYPH cord-337849-tyabf12r 71 32 infected infect VBN cord-337849-tyabf12r 71 33 cells cell NNS cord-337849-tyabf12r 71 34 , , , cord-337849-tyabf12r 71 35 apoptotic apoptotic JJ cord-337849-tyabf12r 71 36 debris debris NN cord-337849-tyabf12r 71 37 and and CC cord-337849-tyabf12r 71 38 serum serum NN cord-337849-tyabf12r 71 39 proteins protein NNS cord-337849-tyabf12r 71 40 , , , cord-337849-tyabf12r 71 41 resulting result VBG cord-337849-tyabf12r 71 42 in in IN cord-337849-tyabf12r 71 43 severe severe JJ cord-337849-tyabf12r 71 44 and and CC cord-337849-tyabf12r 71 45 potentially potentially RB cord-337849-tyabf12r 71 46 fatal fatal JJ cord-337849-tyabf12r 71 47 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 71 48 [ [ -LRB- cord-337849-tyabf12r 71 49 57 57 CD cord-337849-tyabf12r 71 50 ] ] -RRB- cord-337849-tyabf12r 71 51 . . . cord-337849-tyabf12r 72 1 Similarly similarly RB cord-337849-tyabf12r 72 2 , , , cord-337849-tyabf12r 72 3 following follow VBG cord-337849-tyabf12r 72 4 influenza influenza NN cord-337849-tyabf12r 72 5 infection infection NN cord-337849-tyabf12r 72 6 in in IN cord-337849-tyabf12r 72 7 mice mice NN cord-337849-tyabf12r 72 8 devoid devoid JJ cord-337849-tyabf12r 72 9 of of IN cord-337849-tyabf12r 72 10 alveolar alveolar JJ cord-337849-tyabf12r 72 11 macrophages macrophage NNS cord-337849-tyabf12r 72 12 , , , cord-337849-tyabf12r 72 13 pulmonary pulmonary JJ cord-337849-tyabf12r 72 14 alveolar alveolar NN cord-337849-tyabf12r 72 15 proteinosis proteinosis NN cord-337849-tyabf12r 72 16 ( ( -LRB- cord-337849-tyabf12r 72 17 PAP PAP NNP cord-337849-tyabf12r 72 18 ) ) -RRB- cord-337849-tyabf12r 72 19 was be VBD cord-337849-tyabf12r 72 20 demonstrated demonstrate VBN cord-337849-tyabf12r 72 21 owing owe VBG cord-337849-tyabf12r 72 22 to to IN cord-337849-tyabf12r 72 23 the the DT cord-337849-tyabf12r 72 24 accumulation accumulation NN cord-337849-tyabf12r 72 25 of of IN cord-337849-tyabf12r 72 26 surfactant surfactant NN cord-337849-tyabf12r 72 27 material material NN cord-337849-tyabf12r 72 28 and and CC cord-337849-tyabf12r 72 29 a a DT cord-337849-tyabf12r 72 30 failure failure NN cord-337849-tyabf12r 72 31 in in IN cord-337849-tyabf12r 72 32 efferocytosis efferocytosis NN cord-337849-tyabf12r 72 33 , , , cord-337849-tyabf12r 72 34 causing cause VBG cord-337849-tyabf12r 72 35 impaired impaired JJ cord-337849-tyabf12r 72 36 gas gas NN cord-337849-tyabf12r 72 37 exchange exchange NN cord-337849-tyabf12r 72 38 and and CC cord-337849-tyabf12r 72 39 fatal fatal JJ cord-337849-tyabf12r 72 40 hypoxia hypoxia NN cord-337849-tyabf12r 72 41 [ [ -LRB- cord-337849-tyabf12r 72 42 58 58 CD cord-337849-tyabf12r 72 43 ] ] -RRB- cord-337849-tyabf12r 72 44 . . . cord-337849-tyabf12r 73 1 Therefore therefore RB cord-337849-tyabf12r 73 2 , , , cord-337849-tyabf12r 73 3 macrophages macrophage NNS cord-337849-tyabf12r 73 4 appear appear VBP cord-337849-tyabf12r 73 5 to to TO cord-337849-tyabf12r 73 6 have have VB cord-337849-tyabf12r 73 7 a a DT cord-337849-tyabf12r 73 8 vital vital JJ cord-337849-tyabf12r 73 9 role role NN cord-337849-tyabf12r 73 10 in in IN cord-337849-tyabf12r 73 11 the the DT cord-337849-tyabf12r 73 12 antiviral antiviral JJ cord-337849-tyabf12r 73 13 immune immune JJ cord-337849-tyabf12r 73 14 response response NN cord-337849-tyabf12r 73 15 , , , cord-337849-tyabf12r 73 16 by by IN cord-337849-tyabf12r 73 17 producing produce VBG cord-337849-tyabf12r 73 18 antimicrobial antimicrobial JJ cord-337849-tyabf12r 73 19 peptides peptide NNS cord-337849-tyabf12r 73 20 during during IN cord-337849-tyabf12r 73 21 the the DT cord-337849-tyabf12r 73 22 innate innate JJ cord-337849-tyabf12r 73 23 response response NN cord-337849-tyabf12r 73 24 , , , cord-337849-tyabf12r 73 25 and and CC cord-337849-tyabf12r 73 26 phagocytosing phagocytose VBG cord-337849-tyabf12r 73 27 dead dead JJ cord-337849-tyabf12r 73 28 cells cell NNS cord-337849-tyabf12r 73 29 and and CC cord-337849-tyabf12r 73 30 cellular cellular JJ cord-337849-tyabf12r 73 31 debris debris NN cord-337849-tyabf12r 73 32 to to TO cord-337849-tyabf12r 73 33 prevent prevent VB cord-337849-tyabf12r 73 34 immunopathology immunopathology NN cord-337849-tyabf12r 73 35 . . . cord-337849-tyabf12r 74 1 PRR PRR NNP cord-337849-tyabf12r 74 2 signalling signalling NN cord-337849-tyabf12r 74 3 facilitates facilitate VBZ cord-337849-tyabf12r 74 4 the the DT cord-337849-tyabf12r 74 5 maturation maturation NN cord-337849-tyabf12r 74 6 and and CC cord-337849-tyabf12r 74 7 trafficking trafficking NN cord-337849-tyabf12r 74 8 of of IN cord-337849-tyabf12r 74 9 dendritic dendritic JJ cord-337849-tyabf12r 74 10 cells cell NNS cord-337849-tyabf12r 74 11 , , , cord-337849-tyabf12r 74 12 with with IN cord-337849-tyabf12r 74 13 the the DT cord-337849-tyabf12r 74 14 release release NN cord-337849-tyabf12r 74 15 of of IN cord-337849-tyabf12r 74 16 the the DT cord-337849-tyabf12r 74 17 chemokines chemokine NNS cord-337849-tyabf12r 74 18 CCL2 CCL2 NNP cord-337849-tyabf12r 74 19 and and CC cord-337849-tyabf12r 74 20 CCL20 CCL20 NNP cord-337849-tyabf12r 74 21 , , , cord-337849-tyabf12r 74 22 and and CC cord-337849-tyabf12r 74 23 increased increase VBN cord-337849-tyabf12r 74 24 expression expression NN cord-337849-tyabf12r 74 25 of of IN cord-337849-tyabf12r 74 26 CCR7 CCR7 NNP cord-337849-tyabf12r 74 27 [ [ -LRB- cord-337849-tyabf12r 74 28 59 59 CD cord-337849-tyabf12r 74 29 , , , cord-337849-tyabf12r 74 30 60 60 CD cord-337849-tyabf12r 74 31 ] ] -RRB- cord-337849-tyabf12r 74 32 . . . cord-337849-tyabf12r 75 1 Thus thus RB cord-337849-tyabf12r 75 2 , , , cord-337849-tyabf12r 75 3 around around IN cord-337849-tyabf12r 75 4 72 72 CD cord-337849-tyabf12r 75 5 h h NN cord-337849-tyabf12r 75 6 after after IN cord-337849-tyabf12r 75 7 infection infection NN cord-337849-tyabf12r 75 8 , , , cord-337849-tyabf12r 75 9 DCs DCs NNP cord-337849-tyabf12r 75 10 with with IN cord-337849-tyabf12r 75 11 antigen antigen NNP cord-337849-tyabf12r 75 12 - - HYPH cord-337849-tyabf12r 75 13 MHC MHC NNP cord-337849-tyabf12r 75 14 complexes complex NNS cord-337849-tyabf12r 75 15 migrate migrate VBP cord-337849-tyabf12r 75 16 through through IN cord-337849-tyabf12r 75 17 the the DT cord-337849-tyabf12r 75 18 afferent afferent JJ cord-337849-tyabf12r 75 19 lymph lymph NN cord-337849-tyabf12r 75 20 vessels vessel NNS cord-337849-tyabf12r 75 21 to to IN cord-337849-tyabf12r 75 22 secondary secondary JJ cord-337849-tyabf12r 75 23 lymph lymph NN cord-337849-tyabf12r 75 24 nodes node NNS cord-337849-tyabf12r 75 25 where where WRB cord-337849-tyabf12r 75 26 they -PRON- PRP cord-337849-tyabf12r 75 27 form form VBP cord-337849-tyabf12r 75 28 interactions interaction NNS cord-337849-tyabf12r 75 29 with with IN cord-337849-tyabf12r 75 30 naive naive JJ cord-337849-tyabf12r 75 31 CD4 CD4 NNP cord-337849-tyabf12r 75 32 + + CC cord-337849-tyabf12r 75 33 and and CC cord-337849-tyabf12r 75 34 CD8 CD8 NNP cord-337849-tyabf12r 75 35 + + CC cord-337849-tyabf12r 75 36 T T NNP cord-337849-tyabf12r 75 37 lymphocytes lymphocyte NNS cord-337849-tyabf12r 75 38 . . . cord-337849-tyabf12r 76 1 These these DT cord-337849-tyabf12r 76 2 T t NN cord-337849-tyabf12r 76 3 - - HYPH cord-337849-tyabf12r 76 4 lymphocytes lymphocyte NNS cord-337849-tyabf12r 76 5 are be VBP cord-337849-tyabf12r 76 6 activated activate VBN cord-337849-tyabf12r 76 7 , , , cord-337849-tyabf12r 76 8 proliferate proliferate VBP cord-337849-tyabf12r 76 9 , , , cord-337849-tyabf12r 76 10 differentiate differentiate VB cord-337849-tyabf12r 76 11 into into IN cord-337849-tyabf12r 76 12 effector effector NN cord-337849-tyabf12r 76 13 T t NN cord-337849-tyabf12r 76 14 - - HYPH cord-337849-tyabf12r 76 15 cells cell NNS cord-337849-tyabf12r 76 16 and and CC cord-337849-tyabf12r 76 17 migrate migrate VBP cord-337849-tyabf12r 76 18 via via IN cord-337849-tyabf12r 76 19 efferent efferent JJ cord-337849-tyabf12r 76 20 lymph lymph NN cord-337849-tyabf12r 76 21 vessels vessel NNS cord-337849-tyabf12r 76 22 into into IN cord-337849-tyabf12r 76 23 the the DT cord-337849-tyabf12r 76 24 circulation circulation NN cord-337849-tyabf12r 76 25 . . . cord-337849-tyabf12r 77 1 Multiple multiple JJ cord-337849-tyabf12r 77 2 chemokines chemokine NNS cord-337849-tyabf12r 77 3 , , , cord-337849-tyabf12r 77 4 such such JJ cord-337849-tyabf12r 77 5 as as IN cord-337849-tyabf12r 77 6 CCL3 CCL3 NNP cord-337849-tyabf12r 77 7 , , , cord-337849-tyabf12r 77 8 CXCL9 CXCL9 NNP cord-337849-tyabf12r 78 1 and and CC cord-337849-tyabf12r 78 2 CXCL10 CXCL10 NNP cord-337849-tyabf12r 78 3 , , , cord-337849-tyabf12r 78 4 are be VBP cord-337849-tyabf12r 78 5 expressed express VBN cord-337849-tyabf12r 78 6 in in IN cord-337849-tyabf12r 78 7 the the DT cord-337849-tyabf12r 78 8 respiratory respiratory JJ cord-337849-tyabf12r 78 9 epithelium epithelium NN cord-337849-tyabf12r 78 10 and and CC cord-337849-tyabf12r 78 11 result result NN cord-337849-tyabf12r 78 12 in in IN cord-337849-tyabf12r 78 13 changes change NNS cord-337849-tyabf12r 78 14 in in IN cord-337849-tyabf12r 78 15 integrin integrin NN cord-337849-tyabf12r 78 16 affinity affinity NN cord-337849-tyabf12r 78 17 , , , cord-337849-tyabf12r 78 18 allowing allow VBG cord-337849-tyabf12r 78 19 effector effector NN cord-337849-tyabf12r 78 20 T T NNP cord-337849-tyabf12r 78 21 - - HYPH cord-337849-tyabf12r 78 22 cells cell NNS cord-337849-tyabf12r 78 23 to to TO cord-337849-tyabf12r 78 24 bind bind VB cord-337849-tyabf12r 78 25 to to IN cord-337849-tyabf12r 78 26 the the DT cord-337849-tyabf12r 78 27 endothelium endothelium NN cord-337849-tyabf12r 78 28 and and CC cord-337849-tyabf12r 78 29 migrate migrate VB cord-337849-tyabf12r 78 30 into into IN cord-337849-tyabf12r 78 31 the the DT cord-337849-tyabf12r 78 32 infected infected JJ cord-337849-tyabf12r 78 33 tissue tissue NN cord-337849-tyabf12r 78 34 [ [ -LRB- cord-337849-tyabf12r 78 35 37 37 CD cord-337849-tyabf12r 78 36 , , , cord-337849-tyabf12r 78 37 [ [ -LRB- cord-337849-tyabf12r 78 38 61 61 CD cord-337849-tyabf12r 78 39 ] ] -RRB- cord-337849-tyabf12r 78 40 [ [ -LRB- cord-337849-tyabf12r 78 41 62 62 CD cord-337849-tyabf12r 78 42 ] ] -RRB- cord-337849-tyabf12r 78 43 [ [ -LRB- cord-337849-tyabf12r 78 44 63 63 CD cord-337849-tyabf12r 78 45 ] ] -RRB- cord-337849-tyabf12r 78 46 [ [ -LRB- cord-337849-tyabf12r 78 47 64 64 CD cord-337849-tyabf12r 78 48 ] ] -RRB- cord-337849-tyabf12r 78 49 . . . cord-337849-tyabf12r 79 1 For for IN cord-337849-tyabf12r 79 2 efficient efficient JJ cord-337849-tyabf12r 79 3 and and CC cord-337849-tyabf12r 79 4 effective effective JJ cord-337849-tyabf12r 79 5 viral viral JJ cord-337849-tyabf12r 79 6 clearance clearance NN cord-337849-tyabf12r 79 7 Th1 th1 NN cord-337849-tyabf12r 79 8 effector effector NN cord-337849-tyabf12r 79 9 T T NNP cord-337849-tyabf12r 79 10 - - HYPH cord-337849-tyabf12r 79 11 cells cell NNS cord-337849-tyabf12r 79 12 are be VBP cord-337849-tyabf12r 79 13 required require VBN cord-337849-tyabf12r 79 14 , , , cord-337849-tyabf12r 79 15 which which WDT cord-337849-tyabf12r 79 16 produce produce VBP cord-337849-tyabf12r 79 17 IL-2 IL-2 NNP cord-337849-tyabf12r 79 18 , , , cord-337849-tyabf12r 79 19 TNF TNF NNP cord-337849-tyabf12r 79 20 - - HYPH cord-337849-tyabf12r 79 21 α α NNP cord-337849-tyabf12r 79 22 and and CC cord-337849-tyabf12r 79 23 IFN IFN NNP cord-337849-tyabf12r 79 24 - - HYPH cord-337849-tyabf12r 79 25 γ γ NNP cord-337849-tyabf12r 79 26 to to TO cord-337849-tyabf12r 79 27 activate activate VB cord-337849-tyabf12r 79 28 NK NK NNP cord-337849-tyabf12r 79 29 cells cell NNS cord-337849-tyabf12r 79 30 and and CC cord-337849-tyabf12r 79 31 induce induce VB cord-337849-tyabf12r 79 32 generation generation NN cord-337849-tyabf12r 79 33 of of IN cord-337849-tyabf12r 79 34 cytolytic cytolytic JJ cord-337849-tyabf12r 79 35 molecules molecule NNS cord-337849-tyabf12r 79 36 . . . cord-337849-tyabf12r 80 1 CD8 CD8 NNP cord-337849-tyabf12r 80 2 + + CC cord-337849-tyabf12r 80 3 effector effector VB cord-337849-tyabf12r 80 4 T T NNP cord-337849-tyabf12r 80 5 - - HYPH cord-337849-tyabf12r 80 6 cells cell NNS cord-337849-tyabf12r 80 7 and and CC cord-337849-tyabf12r 80 8 NK NK NNP cord-337849-tyabf12r 80 9 cells cell NNS cord-337849-tyabf12r 80 10 can can MD cord-337849-tyabf12r 80 11 then then RB cord-337849-tyabf12r 80 12 induce induce VB cord-337849-tyabf12r 80 13 apoptosis apoptosis NN cord-337849-tyabf12r 80 14 of of IN cord-337849-tyabf12r 80 15 infected infected JJ cord-337849-tyabf12r 80 16 cells cell NNS cord-337849-tyabf12r 80 17 via via IN cord-337849-tyabf12r 80 18 the the DT cord-337849-tyabf12r 80 19 release release NN cord-337849-tyabf12r 80 20 of of IN cord-337849-tyabf12r 80 21 cytolytic cytolytic JJ cord-337849-tyabf12r 80 22 granules granule NNS cord-337849-tyabf12r 80 23 or or CC cord-337849-tyabf12r 80 24 by by IN cord-337849-tyabf12r 80 25 direct direct JJ cord-337849-tyabf12r 80 26 interaction interaction NN cord-337849-tyabf12r 80 27 between between IN cord-337849-tyabf12r 80 28 surface surface NN cord-337849-tyabf12r 80 29 Fas Fas NNP cord-337849-tyabf12r 80 30 receptor receptor NN cord-337849-tyabf12r 80 31 and and CC cord-337849-tyabf12r 80 32 Fas Fas NNP cord-337849-tyabf12r 80 33 ligand ligand NN cord-337849-tyabf12r 80 34 ( ( -LRB- cord-337849-tyabf12r 80 35 FasL FasL NNP cord-337849-tyabf12r 80 36 ) ) -RRB- cord-337849-tyabf12r 80 37 [ [ -LRB- cord-337849-tyabf12r 80 38 37 37 CD cord-337849-tyabf12r 80 39 ] ] -RRB- cord-337849-tyabf12r 80 40 . . . cord-337849-tyabf12r 81 1 B b NN cord-337849-tyabf12r 81 2 - - HYPH cord-337849-tyabf12r 81 3 cells cell NNS cord-337849-tyabf12r 81 4 have have VBP cord-337849-tyabf12r 81 5 also also RB cord-337849-tyabf12r 81 6 been be VBN cord-337849-tyabf12r 81 7 demonstrated demonstrate VBN cord-337849-tyabf12r 81 8 to to TO cord-337849-tyabf12r 81 9 play play VB cord-337849-tyabf12r 81 10 an an DT cord-337849-tyabf12r 81 11 important important JJ cord-337849-tyabf12r 81 12 role role NN cord-337849-tyabf12r 81 13 in in IN cord-337849-tyabf12r 81 14 the the DT cord-337849-tyabf12r 81 15 immune immune JJ cord-337849-tyabf12r 81 16 response response NN cord-337849-tyabf12r 81 17 to to IN cord-337849-tyabf12r 81 18 highly highly RB cord-337849-tyabf12r 81 19 pathogenic pathogenic JJ cord-337849-tyabf12r 81 20 viral viral JJ cord-337849-tyabf12r 81 21 infections infection NNS cord-337849-tyabf12r 81 22 . . . cord-337849-tyabf12r 82 1 Contact contact NN cord-337849-tyabf12r 82 2 between between IN cord-337849-tyabf12r 82 3 CD4 CD4 NNP cord-337849-tyabf12r 82 4 + + CC cord-337849-tyabf12r 82 5 T T NNP cord-337849-tyabf12r 82 6 - - HYPH cord-337849-tyabf12r 82 7 cells cell NNS cord-337849-tyabf12r 82 8 and and CC cord-337849-tyabf12r 82 9 naive naive JJ cord-337849-tyabf12r 82 10 B b NN cord-337849-tyabf12r 82 11 - - HYPH cord-337849-tyabf12r 82 12 cells cell NNS cord-337849-tyabf12r 82 13 in in IN cord-337849-tyabf12r 82 14 secondary secondary JJ cord-337849-tyabf12r 82 15 lymphoid lymphoid JJ cord-337849-tyabf12r 82 16 tissues tissue NNS cord-337849-tyabf12r 82 17 results result NNS cord-337849-tyabf12r 82 18 in in IN cord-337849-tyabf12r 82 19 their -PRON- PRP$ cord-337849-tyabf12r 82 20 proliferation proliferation NN cord-337849-tyabf12r 82 21 and and CC cord-337849-tyabf12r 82 22 antibody antibody NN cord-337849-tyabf12r 82 23 class class NN cord-337849-tyabf12r 82 24 - - HYPH cord-337849-tyabf12r 82 25 switching switching NN cord-337849-tyabf12r 82 26 , , , cord-337849-tyabf12r 82 27 with with IN cord-337849-tyabf12r 82 28 neutralizing neutralize VBG cord-337849-tyabf12r 82 29 virus virus NN cord-337849-tyabf12r 82 30 - - HYPH cord-337849-tyabf12r 82 31 specific specific JJ cord-337849-tyabf12r 82 32 antibodies antibody NNS cord-337849-tyabf12r 82 33 crucial crucial JJ cord-337849-tyabf12r 82 34 for for IN cord-337849-tyabf12r 82 35 optimal optimal JJ cord-337849-tyabf12r 82 36 viral viral JJ cord-337849-tyabf12r 82 37 clearance clearance NN cord-337849-tyabf12r 82 38 . . . cord-337849-tyabf12r 83 1 Additionally additionally RB cord-337849-tyabf12r 83 2 , , , cord-337849-tyabf12r 83 3 viral viral JJ cord-337849-tyabf12r 83 4 components component NNS cord-337849-tyabf12r 83 5 expressed express VBN cord-337849-tyabf12r 83 6 on on IN cord-337849-tyabf12r 83 7 infected infected JJ cord-337849-tyabf12r 83 8 cells cell NNS cord-337849-tyabf12r 83 9 allow allow VBP cord-337849-tyabf12r 83 10 antibodies antibody NNS cord-337849-tyabf12r 83 11 to to TO cord-337849-tyabf12r 83 12 bind bind VB cord-337849-tyabf12r 83 13 , , , cord-337849-tyabf12r 83 14 thus thus RB cord-337849-tyabf12r 83 15 initiating initiate VBG cord-337849-tyabf12r 83 16 antibody antibody NN cord-337849-tyabf12r 83 17 - - HYPH cord-337849-tyabf12r 83 18 dependent dependent JJ cord-337849-tyabf12r 83 19 cell cell NN cord-337849-tyabf12r 83 20 - - HYPH cord-337849-tyabf12r 83 21 mediated mediate VBN cord-337849-tyabf12r 83 22 cytotoxicity cytotoxicity NN cord-337849-tyabf12r 83 23 ( ( -LRB- cord-337849-tyabf12r 83 24 ADCC ADCC NNP cord-337849-tyabf12r 83 25 ) ) -RRB- cord-337849-tyabf12r 83 26 , , , cord-337849-tyabf12r 83 27 whereby whereby WRB cord-337849-tyabf12r 83 28 CD16 CD16 NNP cord-337849-tyabf12r 83 29 on on IN cord-337849-tyabf12r 83 30 NK NK NNP cord-337849-tyabf12r 83 31 cells cell NNS cord-337849-tyabf12r 83 32 recognises recognise VBZ cord-337849-tyabf12r 83 33 the the DT cord-337849-tyabf12r 83 34 Fc Fc NNP cord-337849-tyabf12r 83 35 portion portion NN cord-337849-tyabf12r 83 36 of of IN cord-337849-tyabf12r 83 37 antibodies antibody NNS cord-337849-tyabf12r 83 38 bound bind VBN cord-337849-tyabf12r 83 39 to to IN cord-337849-tyabf12r 83 40 the the DT cord-337849-tyabf12r 83 41 surface surface NN cord-337849-tyabf12r 83 42 and and CC cord-337849-tyabf12r 83 43 kills kill VBZ cord-337849-tyabf12r 83 44 the the DT cord-337849-tyabf12r 83 45 target target NN cord-337849-tyabf12r 83 46 cell cell NN cord-337849-tyabf12r 83 47 [ [ -LRB- cord-337849-tyabf12r 83 48 37 37 CD cord-337849-tyabf12r 83 49 , , , cord-337849-tyabf12r 83 50 [ [ -LRB- cord-337849-tyabf12r 83 51 65 65 CD cord-337849-tyabf12r 83 52 ] ] -RRB- cord-337849-tyabf12r 84 1 [ [ -LRB- cord-337849-tyabf12r 84 2 66 66 CD cord-337849-tyabf12r 84 3 ] ] -RRB- cord-337849-tyabf12r 85 1 [ [ -LRB- cord-337849-tyabf12r 85 2 67 67 CD cord-337849-tyabf12r 85 3 ] ] -RRB- cord-337849-tyabf12r 85 4 . . . cord-337849-tyabf12r 86 1 Complement complement NN cord-337849-tyabf12r 86 2 is be VBZ cord-337849-tyabf12r 86 3 also also RB cord-337849-tyabf12r 86 4 increasingly increasingly RB cord-337849-tyabf12r 86 5 being be VBG cord-337849-tyabf12r 86 6 recognised recognise VBN cord-337849-tyabf12r 86 7 as as IN cord-337849-tyabf12r 86 8 an an DT cord-337849-tyabf12r 86 9 important important JJ cord-337849-tyabf12r 86 10 component component NN cord-337849-tyabf12r 86 11 of of IN cord-337849-tyabf12r 86 12 anti anti JJ cord-337849-tyabf12r 86 13 - - JJ cord-337849-tyabf12r 86 14 viral viral JJ cord-337849-tyabf12r 86 15 immunity immunity NN cord-337849-tyabf12r 86 16 , , , cord-337849-tyabf12r 86 17 as as IN cord-337849-tyabf12r 86 18 reviewed review VBN cord-337849-tyabf12r 86 19 elsewhere elsewhere RB cord-337849-tyabf12r 86 20 [ [ -LRB- cord-337849-tyabf12r 86 21 68 68 CD cord-337849-tyabf12r 86 22 ] ] -RRB- cord-337849-tyabf12r 86 23 . . . cord-337849-tyabf12r 87 1 The the DT cord-337849-tyabf12r 87 2 evolution evolution NN cord-337849-tyabf12r 87 3 of of IN cord-337849-tyabf12r 87 4 evasion evasion NN cord-337849-tyabf12r 87 5 mechanisms mechanism NNS cord-337849-tyabf12r 87 6 by by IN cord-337849-tyabf12r 87 7 viruses virus NNS cord-337849-tyabf12r 87 8 emphasises emphasise VBZ cord-337849-tyabf12r 87 9 the the DT cord-337849-tyabf12r 87 10 importance importance NN cord-337849-tyabf12r 87 11 of of IN cord-337849-tyabf12r 87 12 complement complement NN cord-337849-tyabf12r 87 13 in in IN cord-337849-tyabf12r 87 14 anti anti JJ cord-337849-tyabf12r 87 15 - - JJ cord-337849-tyabf12r 87 16 viral viral JJ cord-337849-tyabf12r 87 17 immunity immunity NN cord-337849-tyabf12r 87 18 , , , cord-337849-tyabf12r 87 19 with with IN cord-337849-tyabf12r 87 20 , , , cord-337849-tyabf12r 87 21 for for IN cord-337849-tyabf12r 87 22 example example NN cord-337849-tyabf12r 87 23 , , , cord-337849-tyabf12r 87 24 the the DT cord-337849-tyabf12r 87 25 matrix matrix NN cord-337849-tyabf12r 87 26 protein protein NN cord-337849-tyabf12r 87 27 M1 M1 NNP cord-337849-tyabf12r 87 28 of of IN cord-337849-tyabf12r 87 29 influenza influenza NN cord-337849-tyabf12r 87 30 A a DT cord-337849-tyabf12r 87 31 able able JJ cord-337849-tyabf12r 87 32 to to TO cord-337849-tyabf12r 87 33 bind bind VB cord-337849-tyabf12r 87 34 to to IN cord-337849-tyabf12r 87 35 C1q C1q NNP cord-337849-tyabf12r 87 36 to to TO cord-337849-tyabf12r 87 37 prevent prevent VB cord-337849-tyabf12r 87 38 interaction interaction NN cord-337849-tyabf12r 87 39 with with IN cord-337849-tyabf12r 87 40 antibodies antibody NNS cord-337849-tyabf12r 87 41 on on IN cord-337849-tyabf12r 87 42 the the DT cord-337849-tyabf12r 87 43 surface surface NN cord-337849-tyabf12r 87 44 of of IN cord-337849-tyabf12r 87 45 infected infected JJ cord-337849-tyabf12r 87 46 cells cell NNS cord-337849-tyabf12r 87 47 [ [ -LRB- cord-337849-tyabf12r 87 48 68 68 CD cord-337849-tyabf12r 87 49 , , , cord-337849-tyabf12r 87 50 69 69 CD cord-337849-tyabf12r 87 51 ] ] -RRB- cord-337849-tyabf12r 87 52 . . . cord-337849-tyabf12r 88 1 Therefore therefore RB cord-337849-tyabf12r 88 2 , , , cord-337849-tyabf12r 88 3 combined combine VBN cord-337849-tyabf12r 88 4 , , , cord-337849-tyabf12r 88 5 these these DT cord-337849-tyabf12r 88 6 effector effector NN cord-337849-tyabf12r 88 7 mechanisms mechanism NNS cord-337849-tyabf12r 88 8 of of IN cord-337849-tyabf12r 88 9 the the DT cord-337849-tyabf12r 88 10 adaptive adaptive JJ cord-337849-tyabf12r 88 11 immune immune JJ cord-337849-tyabf12r 88 12 response response NN cord-337849-tyabf12r 88 13 rapidly rapidly RB cord-337849-tyabf12r 88 14 clear clear VBD cord-337849-tyabf12r 88 15 the the DT cord-337849-tyabf12r 88 16 viral viral JJ cord-337849-tyabf12r 88 17 infection infection NN cord-337849-tyabf12r 88 18 . . . cord-337849-tyabf12r 89 1 Vitamin vitamin NN cord-337849-tyabf12r 89 2 D d NN cord-337849-tyabf12r 89 3 ( ( -LRB- cord-337849-tyabf12r 89 4 cholecalciferol cholecalciferol NNP cord-337849-tyabf12r 89 5 ) ) -RRB- cord-337849-tyabf12r 89 6 is be VBZ cord-337849-tyabf12r 89 7 acquired acquire VBN cord-337849-tyabf12r 89 8 from from IN cord-337849-tyabf12r 89 9 dietary dietary JJ cord-337849-tyabf12r 89 10 sources source NNS cord-337849-tyabf12r 89 11 , , , cord-337849-tyabf12r 89 12 primarily primarily RB cord-337849-tyabf12r 89 13 oily oily JJ cord-337849-tyabf12r 89 14 fish fish NN cord-337849-tyabf12r 89 15 , , , cord-337849-tyabf12r 89 16 or or CC cord-337849-tyabf12r 89 17 from from IN cord-337849-tyabf12r 89 18 UV uv NN cord-337849-tyabf12r 89 19 - - HYPH cord-337849-tyabf12r 89 20 mediated mediate VBN cord-337849-tyabf12r 89 21 synthesis synthesis NN cord-337849-tyabf12r 89 22 in in IN cord-337849-tyabf12r 89 23 the the DT cord-337849-tyabf12r 89 24 skin skin NN cord-337849-tyabf12r 89 25 , , , cord-337849-tyabf12r 89 26 before before IN cord-337849-tyabf12r 89 27 it -PRON- PRP cord-337849-tyabf12r 89 28 is be VBZ cord-337849-tyabf12r 89 29 metabolised metabolise VBN cord-337849-tyabf12r 89 30 in in IN cord-337849-tyabf12r 89 31 the the DT cord-337849-tyabf12r 89 32 liver liver NN cord-337849-tyabf12r 89 33 to to TO cord-337849-tyabf12r 89 34 form form VB cord-337849-tyabf12r 89 35 25(OH)D3 25(oh)d3 CD cord-337849-tyabf12r 89 36 . . . cord-337849-tyabf12r 90 1 This this DT cord-337849-tyabf12r 90 2 25(OH)D3 25(oh)d3 CD cord-337849-tyabf12r 90 3 is be VBZ cord-337849-tyabf12r 90 4 the the DT cord-337849-tyabf12r 90 5 circulating circulate VBG cord-337849-tyabf12r 90 6 form form NN cord-337849-tyabf12r 90 7 of of IN cord-337849-tyabf12r 90 8 vitamin vitamin NN cord-337849-tyabf12r 90 9 D d NN cord-337849-tyabf12r 90 10 , , , cord-337849-tyabf12r 90 11 with with IN cord-337849-tyabf12r 90 12 a a DT cord-337849-tyabf12r 90 13 half half JJ cord-337849-tyabf12r 90 14 - - HYPH cord-337849-tyabf12r 90 15 life life NN cord-337849-tyabf12r 90 16 estimated estimate VBN cord-337849-tyabf12r 90 17 to to TO cord-337849-tyabf12r 90 18 range range VB cord-337849-tyabf12r 90 19 from from IN cord-337849-tyabf12r 90 20 two two CD cord-337849-tyabf12r 90 21 weeks week NNS cord-337849-tyabf12r 90 22 to to IN cord-337849-tyabf12r 90 23 two two CD cord-337849-tyabf12r 90 24 months month NNS cord-337849-tyabf12r 90 25 [ [ -LRB- cord-337849-tyabf12r 90 26 70 70 CD cord-337849-tyabf12r 90 27 ] ] -RRB- cord-337849-tyabf12r 90 28 [ [ -LRB- cord-337849-tyabf12r 90 29 71 71 CD cord-337849-tyabf12r 90 30 ] ] -RRB- cord-337849-tyabf12r 90 31 [ [ -LRB- cord-337849-tyabf12r 90 32 72 72 CD cord-337849-tyabf12r 90 33 ] ] -RRB- cord-337849-tyabf12r 90 34 , , , cord-337849-tyabf12r 90 35 and and CC cord-337849-tyabf12r 90 36 its -PRON- PRP$ cord-337849-tyabf12r 90 37 serum serum NN cord-337849-tyabf12r 90 38 concentration concentration NN cord-337849-tyabf12r 90 39 is be VBZ cord-337849-tyabf12r 90 40 used use VBN cord-337849-tyabf12r 90 41 to to TO cord-337849-tyabf12r 90 42 define define VB cord-337849-tyabf12r 90 43 vitamin vitamin NN cord-337849-tyabf12r 90 44 D d NN cord-337849-tyabf12r 90 45 status status NN cord-337849-tyabf12r 90 46 . . . cord-337849-tyabf12r 91 1 Further further JJ cord-337849-tyabf12r 91 2 hydroxylation hydroxylation NN cord-337849-tyabf12r 91 3 results result NNS cord-337849-tyabf12r 91 4 in in IN cord-337849-tyabf12r 91 5 the the DT cord-337849-tyabf12r 91 6 synthesis synthesis NN cord-337849-tyabf12r 91 7 of of IN cord-337849-tyabf12r 91 8 1α,25(OH)2D3 1α,25(oh)2d3 CD cord-337849-tyabf12r 91 9 and and CC cord-337849-tyabf12r 91 10 ligation ligation NN cord-337849-tyabf12r 91 11 of of IN cord-337849-tyabf12r 91 12 nuclear nuclear JJ cord-337849-tyabf12r 91 13 vitamin vitamin NN cord-337849-tyabf12r 91 14 D D NNP cord-337849-tyabf12r 91 15 receptors receptor NNS cord-337849-tyabf12r 91 16 ( ( -LRB- cord-337849-tyabf12r 91 17 VDRs VDRs NNP cord-337849-tyabf12r 91 18 ) ) -RRB- cord-337849-tyabf12r 91 19 , , , cord-337849-tyabf12r 91 20 allowing allow VBG cord-337849-tyabf12r 91 21 subsequent subsequent JJ cord-337849-tyabf12r 91 22 binding binding NN cord-337849-tyabf12r 91 23 to to IN cord-337849-tyabf12r 91 24 vitamin vitamin NN cord-337849-tyabf12r 91 25 D d NN cord-337849-tyabf12r 91 26 responsive responsive JJ cord-337849-tyabf12r 91 27 elements element NNS cord-337849-tyabf12r 91 28 ( ( -LRB- cord-337849-tyabf12r 91 29 VDREs VDREs NNP cord-337849-tyabf12r 91 30 ) ) -RRB- cord-337849-tyabf12r 91 31 in in IN cord-337849-tyabf12r 91 32 promoter promoter NN cord-337849-tyabf12r 91 33 regions region NNS cord-337849-tyabf12r 91 34 of of IN cord-337849-tyabf12r 91 35 specific specific JJ cord-337849-tyabf12r 91 36 genes gene NNS cord-337849-tyabf12r 91 37 , , , cord-337849-tyabf12r 91 38 resulting result VBG cord-337849-tyabf12r 91 39 in in IN cord-337849-tyabf12r 91 40 the the DT cord-337849-tyabf12r 91 41 repression repression NN cord-337849-tyabf12r 91 42 or or CC cord-337849-tyabf12r 91 43 induction induction NN cord-337849-tyabf12r 91 44 of of IN cord-337849-tyabf12r 91 45 gene gene NN cord-337849-tyabf12r 91 46 transcription transcription NN cord-337849-tyabf12r 91 47 [ [ -LRB- cord-337849-tyabf12r 91 48 11 11 CD cord-337849-tyabf12r 91 49 ] ] -RRB- cord-337849-tyabf12r 92 1 ( ( -LRB- cord-337849-tyabf12r 92 2 Figure figure NN cord-337849-tyabf12r 92 3 2 2 CD cord-337849-tyabf12r 92 4 ) ) -RRB- cord-337849-tyabf12r 92 5 . . . cord-337849-tyabf12r 93 1 VDRs vdr NNS cord-337849-tyabf12r 93 2 have have VBP cord-337849-tyabf12r 93 3 also also RB cord-337849-tyabf12r 93 4 been be VBN cord-337849-tyabf12r 93 5 shown show VBN cord-337849-tyabf12r 93 6 to to TO cord-337849-tyabf12r 93 7 be be VB cord-337849-tyabf12r 93 8 located locate VBN cord-337849-tyabf12r 93 9 within within IN cord-337849-tyabf12r 93 10 the the DT cord-337849-tyabf12r 93 11 plasma plasma NN cord-337849-tyabf12r 93 12 membrane membrane NN cord-337849-tyabf12r 93 13 or or CC cord-337849-tyabf12r 93 14 its -PRON- PRP$ cord-337849-tyabf12r 93 15 caveolae caveolae NN cord-337849-tyabf12r 93 16 components component NNS cord-337849-tyabf12r 93 17 [ [ -LRB- cord-337849-tyabf12r 93 18 73 73 CD cord-337849-tyabf12r 93 19 ] ] -RRB- cord-337849-tyabf12r 93 20 [ [ -LRB- cord-337849-tyabf12r 93 21 74 74 CD cord-337849-tyabf12r 93 22 ] ] -RRB- cord-337849-tyabf12r 93 23 [ [ -LRB- cord-337849-tyabf12r 93 24 75 75 CD cord-337849-tyabf12r 93 25 ] ] -RRB- cord-337849-tyabf12r 93 26 , , , cord-337849-tyabf12r 93 27 with with IN cord-337849-tyabf12r 93 28 ligation ligation NN cord-337849-tyabf12r 93 29 resulting result VBG cord-337849-tyabf12r 93 30 in in IN cord-337849-tyabf12r 93 31 1α,25(OH)2D3-mediated 1α,25(oh)2d3-mediated JJ cord-337849-tyabf12r 93 32 non non JJ cord-337849-tyabf12r 93 33 - - JJ cord-337849-tyabf12r 93 34 genomic genomic JJ cord-337849-tyabf12r 93 35 rapid rapid JJ cord-337849-tyabf12r 93 36 responses response NNS cord-337849-tyabf12r 93 37 via via IN cord-337849-tyabf12r 93 38 the the DT cord-337849-tyabf12r 93 39 activation activation NN cord-337849-tyabf12r 93 40 of of IN cord-337849-tyabf12r 93 41 second second JJ cord-337849-tyabf12r 93 42 messenger messenger NN cord-337849-tyabf12r 93 43 systems system NNS cord-337849-tyabf12r 93 44 , , , cord-337849-tyabf12r 93 45 such such JJ cord-337849-tyabf12r 93 46 as as IN cord-337849-tyabf12r 93 47 phospholipase phospholipase NN cord-337849-tyabf12r 93 48 C c NN cord-337849-tyabf12r 93 49 , , , cord-337849-tyabf12r 93 50 protein protein NN cord-337849-tyabf12r 93 51 kinase kinase NN cord-337849-tyabf12r 93 52 C c NN cord-337849-tyabf12r 93 53 and and CC cord-337849-tyabf12r 93 54 phosphatidylinositol-3′kinase phosphatidylinositol-3′kinase NN cord-337849-tyabf12r 94 1 ( ( -LRB- cord-337849-tyabf12r 94 2 PI3 PI3 NNP cord-337849-tyabf12r 94 3 K K NNP cord-337849-tyabf12r 94 4 ) ) -RRB- cord-337849-tyabf12r 94 5 , , , cord-337849-tyabf12r 94 6 thus thus RB cord-337849-tyabf12r 94 7 initiating initiate VBG cord-337849-tyabf12r 94 8 various various JJ cord-337849-tyabf12r 94 9 intracellular intracellular JJ cord-337849-tyabf12r 94 10 effects effect NNS cord-337849-tyabf12r 94 11 , , , cord-337849-tyabf12r 94 12 such such JJ cord-337849-tyabf12r 94 13 as as IN cord-337849-tyabf12r 94 14 the the DT cord-337849-tyabf12r 94 15 opening opening NN cord-337849-tyabf12r 94 16 of of IN cord-337849-tyabf12r 94 17 voltage voltage NN cord-337849-tyabf12r 94 18 - - HYPH cord-337849-tyabf12r 94 19 gated gate VBN cord-337849-tyabf12r 94 20 calcium calcium NN cord-337849-tyabf12r 94 21 channels channel NNS cord-337849-tyabf12r 94 22 and and CC cord-337849-tyabf12r 94 23 Ras Ras NNP cord-337849-tyabf12r 94 24 / / SYM cord-337849-tyabf12r 94 25 MAPK MAPK NNP cord-337849-tyabf12r 94 26 signal signal NN cord-337849-tyabf12r 94 27 transduction transduction NN cord-337849-tyabf12r 94 28 [ [ -LRB- cord-337849-tyabf12r 94 29 75 75 CD cord-337849-tyabf12r 94 30 , , , cord-337849-tyabf12r 94 31 76 76 CD cord-337849-tyabf12r 94 32 ] ] -RRB- cord-337849-tyabf12r 94 33 . . . cord-337849-tyabf12r 95 1 The the DT cord-337849-tyabf12r 95 2 detection detection NN cord-337849-tyabf12r 95 3 of of IN cord-337849-tyabf12r 95 4 VDR VDR NNP cord-337849-tyabf12r 95 5 abundance abundance NN cord-337849-tyabf12r 95 6 throughout throughout IN cord-337849-tyabf12r 95 7 the the DT cord-337849-tyabf12r 95 8 immune immune JJ cord-337849-tyabf12r 95 9 system system NN cord-337849-tyabf12r 95 10 , , , cord-337849-tyabf12r 95 11 the the DT cord-337849-tyabf12r 95 12 observation observation NN cord-337849-tyabf12r 95 13 that that IN cord-337849-tyabf12r 95 14 VDR VDR NNP cord-337849-tyabf12r 95 15 expression expression NN cord-337849-tyabf12r 95 16 is be VBZ cord-337849-tyabf12r 95 17 regulated regulate VBN cord-337849-tyabf12r 95 18 by by IN cord-337849-tyabf12r 95 19 immune immune JJ cord-337849-tyabf12r 95 20 signalling signalling NN cord-337849-tyabf12r 95 21 , , , cord-337849-tyabf12r 95 22 and and CC cord-337849-tyabf12r 95 23 the the DT cord-337849-tyabf12r 95 24 detection detection NN cord-337849-tyabf12r 95 25 of of IN cord-337849-tyabf12r 95 26 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 95 27 expression expression NN cord-337849-tyabf12r 95 28 by by IN cord-337849-tyabf12r 95 29 immune immune JJ cord-337849-tyabf12r 95 30 cells cell NNS cord-337849-tyabf12r 95 31 has have VBZ cord-337849-tyabf12r 95 32 directed direct VBN cord-337849-tyabf12r 95 33 vitamin vitamin NN cord-337849-tyabf12r 95 34 D d NN cord-337849-tyabf12r 95 35 research research NN cord-337849-tyabf12r 95 36 into into IN cord-337849-tyabf12r 95 37 the the DT cord-337849-tyabf12r 95 38 area area NN cord-337849-tyabf12r 95 39 of of IN cord-337849-tyabf12r 95 40 immunology immunology NN cord-337849-tyabf12r 95 41 [ [ -LRB- cord-337849-tyabf12r 95 42 77 77 CD cord-337849-tyabf12r 95 43 ] ] -RRB- cord-337849-tyabf12r 95 44 [ [ -LRB- cord-337849-tyabf12r 95 45 78 78 CD cord-337849-tyabf12r 95 46 ] ] -RRB- cord-337849-tyabf12r 95 47 [ [ -LRB- cord-337849-tyabf12r 95 48 79 79 CD cord-337849-tyabf12r 95 49 ] ] -RRB- cord-337849-tyabf12r 96 1 [ [ -LRB- cord-337849-tyabf12r 96 2 80 80 CD cord-337849-tyabf12r 96 3 ] ] -RRB- cord-337849-tyabf12r 97 1 [ [ -LRB- cord-337849-tyabf12r 97 2 81 81 CD cord-337849-tyabf12r 97 3 ] ] -RRB- cord-337849-tyabf12r 97 4 , , , cord-337849-tyabf12r 97 5 with with IN cord-337849-tyabf12r 97 6 associations association NNS cord-337849-tyabf12r 97 7 of of IN cord-337849-tyabf12r 97 8 low low JJ cord-337849-tyabf12r 97 9 serum serum NN cord-337849-tyabf12r 97 10 25(OH)D3 25(oh)d3 CD cord-337849-tyabf12r 97 11 levels level NNS cord-337849-tyabf12r 97 12 seen see VBN cord-337849-tyabf12r 97 13 with with IN cord-337849-tyabf12r 97 14 autoimmune autoimmune JJ cord-337849-tyabf12r 97 15 diseases disease NNS cord-337849-tyabf12r 97 16 , , , cord-337849-tyabf12r 97 17 cancer cancer NN cord-337849-tyabf12r 97 18 , , , cord-337849-tyabf12r 97 19 cardiovascular cardiovascular JJ cord-337849-tyabf12r 97 20 disease disease NN cord-337849-tyabf12r 97 21 and and CC cord-337849-tyabf12r 97 22 respiratory respiratory JJ cord-337849-tyabf12r 97 23 infections infection NNS cord-337849-tyabf12r 97 24 [ [ -LRB- cord-337849-tyabf12r 97 25 82 82 CD cord-337849-tyabf12r 97 26 ] ] -RRB- cord-337849-tyabf12r 97 27 [ [ -LRB- cord-337849-tyabf12r 97 28 83 83 CD cord-337849-tyabf12r 97 29 ] ] -RRB- cord-337849-tyabf12r 97 30 [ [ -LRB- cord-337849-tyabf12r 97 31 84 84 CD cord-337849-tyabf12r 97 32 ] ] -RRB- cord-337849-tyabf12r 97 33 [ [ -LRB- cord-337849-tyabf12r 97 34 85 85 CD cord-337849-tyabf12r 97 35 ] ] -RRB- cord-337849-tyabf12r 97 36 . . . cord-337849-tyabf12r 98 1 Significantly significantly RB cord-337849-tyabf12r 98 2 , , , cord-337849-tyabf12r 98 3 a a DT cord-337849-tyabf12r 98 4 link link NN cord-337849-tyabf12r 98 5 has have VBZ cord-337849-tyabf12r 98 6 been be VBN cord-337849-tyabf12r 98 7 made make VBN cord-337849-tyabf12r 98 8 between between IN cord-337849-tyabf12r 98 9 TLR TLR NNP cord-337849-tyabf12r 98 10 ligation ligation NN cord-337849-tyabf12r 98 11 and and CC cord-337849-tyabf12r 98 12 cytokine cytokine NN cord-337849-tyabf12r 98 13 secretion secretion NN cord-337849-tyabf12r 98 14 , , , cord-337849-tyabf12r 98 15 the the DT cord-337849-tyabf12r 98 16 expression expression NN cord-337849-tyabf12r 98 17 of of IN cord-337849-tyabf12r 98 18 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 98 19 and and CC cord-337849-tyabf12r 98 20 the the DT cord-337849-tyabf12r 98 21 expression expression NN cord-337849-tyabf12r 98 22 of of IN cord-337849-tyabf12r 98 23 the the DT cord-337849-tyabf12r 98 24 VDR VDR NNP cord-337849-tyabf12r 98 25 . . . cord-337849-tyabf12r 99 1 In in IN cord-337849-tyabf12r 99 2 the the DT cord-337849-tyabf12r 99 3 absence absence NN cord-337849-tyabf12r 99 4 of of IN cord-337849-tyabf12r 99 5 any any DT cord-337849-tyabf12r 99 6 influence influence NN cord-337849-tyabf12r 99 7 by by IN cord-337849-tyabf12r 99 8 calcium calcium NN cord-337849-tyabf12r 99 9 homeostatic homeostatic JJ cord-337849-tyabf12r 99 10 agents agent NNS cord-337849-tyabf12r 99 11 [ [ -LRB- cord-337849-tyabf12r 99 12 86 86 CD cord-337849-tyabf12r 99 13 ] ] -RRB- cord-337849-tyabf12r 99 14 [ [ -LRB- cord-337849-tyabf12r 99 15 87 87 CD cord-337849-tyabf12r 99 16 ] ] -RRB- cord-337849-tyabf12r 99 17 [ [ -LRB- cord-337849-tyabf12r 99 18 88 88 CD cord-337849-tyabf12r 99 19 ] ] -RRB- cord-337849-tyabf12r 99 20 , , , cord-337849-tyabf12r 99 21 and and CC cord-337849-tyabf12r 99 22 with with IN cord-337849-tyabf12r 99 23 a a DT cord-337849-tyabf12r 99 24 defective defective JJ cord-337849-tyabf12r 99 25 negative negative JJ cord-337849-tyabf12r 99 26 feedback feedback NN cord-337849-tyabf12r 99 27 mechanism mechanism NN cord-337849-tyabf12r 99 28 [ [ -LRB- cord-337849-tyabf12r 99 29 89 89 CD cord-337849-tyabf12r 99 30 , , , cord-337849-tyabf12r 99 31 90 90 CD cord-337849-tyabf12r 99 32 ] ] -RRB- cord-337849-tyabf12r 99 33 , , , cord-337849-tyabf12r 99 34 extra extra JJ cord-337849-tyabf12r 99 35 - - JJ cord-337849-tyabf12r 99 36 renal renal JJ cord-337849-tyabf12r 99 37 1α 1α CD cord-337849-tyabf12r 99 38 - - HYPH cord-337849-tyabf12r 99 39 hydroxylation hydroxylation NN cord-337849-tyabf12r 99 40 in in IN cord-337849-tyabf12r 99 41 cells cell NNS cord-337849-tyabf12r 99 42 such such JJ cord-337849-tyabf12r 99 43 as as IN cord-337849-tyabf12r 99 44 monocytes monocyte NNS cord-337849-tyabf12r 99 45 and and CC cord-337849-tyabf12r 99 46 macrophages macrophage NNS cord-337849-tyabf12r 99 47 is be VBZ cord-337849-tyabf12r 99 48 regulated regulate VBN cord-337849-tyabf12r 99 49 primarily primarily RB cord-337849-tyabf12r 99 50 by by IN cord-337849-tyabf12r 99 51 immune immune JJ cord-337849-tyabf12r 99 52 inputs input NNS cord-337849-tyabf12r 99 53 . . . cord-337849-tyabf12r 100 1 Therefore therefore RB cord-337849-tyabf12r 100 2 , , , cord-337849-tyabf12r 100 3 this this DT cord-337849-tyabf12r 100 4 renders render VBZ cord-337849-tyabf12r 100 5 the the DT cord-337849-tyabf12r 100 6 immune immune JJ cord-337849-tyabf12r 100 7 system system NN cord-337849-tyabf12r 100 8 responsive responsive JJ cord-337849-tyabf12r 100 9 to to IN cord-337849-tyabf12r 100 10 circulating circulate VBG cord-337849-tyabf12r 100 11 levels level NNS cord-337849-tyabf12r 100 12 of of IN cord-337849-tyabf12r 100 13 25(OH)D 25(oh)d CD cord-337849-tyabf12r 100 14 and and CC cord-337849-tyabf12r 100 15 allows allow VBZ cord-337849-tyabf12r 100 16 the the DT cord-337849-tyabf12r 100 17 sustained sustained JJ cord-337849-tyabf12r 100 18 and and CC cord-337849-tyabf12r 100 19 potentially potentially RB cord-337849-tyabf12r 100 20 beneficial beneficial JJ cord-337849-tyabf12r 100 21 production production NN cord-337849-tyabf12r 100 22 of of IN cord-337849-tyabf12r 100 23 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 100 24 during during IN cord-337849-tyabf12r 100 25 an an DT cord-337849-tyabf12r 100 26 immune immune JJ cord-337849-tyabf12r 100 27 response response NN cord-337849-tyabf12r 100 28 [ [ -LRB- cord-337849-tyabf12r 100 29 90 90 CD cord-337849-tyabf12r 100 30 ] ] -RRB- cord-337849-tyabf12r 100 31 . . . cord-337849-tyabf12r 101 1 Vitamin vitamin NN cord-337849-tyabf12r 101 2 D d NN cord-337849-tyabf12r 101 3 metabolism metabolism NN cord-337849-tyabf12r 101 4 in in IN cord-337849-tyabf12r 101 5 macrophages macrophage NNS cord-337849-tyabf12r 101 6 is be VBZ cord-337849-tyabf12r 101 7 linked link VBN cord-337849-tyabf12r 101 8 to to IN cord-337849-tyabf12r 101 9 pathogen pathogen NN cord-337849-tyabf12r 101 10 recognition recognition NN cord-337849-tyabf12r 101 11 , , , cord-337849-tyabf12r 101 12 thus thus RB cord-337849-tyabf12r 101 13 making make VBG cord-337849-tyabf12r 101 14 it -PRON- PRP cord-337849-tyabf12r 101 15 an an DT cord-337849-tyabf12r 101 16 integral integral JJ cord-337849-tyabf12r 101 17 part part NN cord-337849-tyabf12r 101 18 of of IN cord-337849-tyabf12r 101 19 the the DT cord-337849-tyabf12r 101 20 innate innate JJ cord-337849-tyabf12r 101 21 immune immune JJ cord-337849-tyabf12r 101 22 response response NN cord-337849-tyabf12r 101 23 [ [ -LRB- cord-337849-tyabf12r 101 24 91 91 CD cord-337849-tyabf12r 101 25 ] ] -RRB- cord-337849-tyabf12r 101 26 . . . cord-337849-tyabf12r 102 1 Ligation ligation NN cord-337849-tyabf12r 102 2 of of IN cord-337849-tyabf12r 102 3 the the DT cord-337849-tyabf12r 102 4 TLR2/1 TLR2/1 NNP cord-337849-tyabf12r 102 5 heterodimer heterodimer NN cord-337849-tyabf12r 102 6 in in IN cord-337849-tyabf12r 102 7 macrophages macrophage NNS cord-337849-tyabf12r 102 8 has have VBZ cord-337849-tyabf12r 102 9 been be VBN cord-337849-tyabf12r 102 10 demonstrated demonstrate VBN cord-337849-tyabf12r 102 11 to to IN cord-337849-tyabf12r 102 12 up up RB cord-337849-tyabf12r 102 13 - - HYPH cord-337849-tyabf12r 102 14 regulate regulate VB cord-337849-tyabf12r 102 15 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 102 16 , , , cord-337849-tyabf12r 102 17 and and CC cord-337849-tyabf12r 102 18 the the DT cord-337849-tyabf12r 102 19 TLR8 TLR8 NNP cord-337849-tyabf12r 102 20 ligands ligand NNS cord-337849-tyabf12r 102 21 CL097 CL097 NNP cord-337849-tyabf12r 102 22 and and CC cord-337849-tyabf12r 102 23 ssRNA40 ssRNA40 NNP cord-337849-tyabf12r 102 24 have have VBP cord-337849-tyabf12r 102 25 also also RB cord-337849-tyabf12r 102 26 both both DT cord-337849-tyabf12r 102 27 been be VBN cord-337849-tyabf12r 102 28 demonstrated demonstrate VBN cord-337849-tyabf12r 102 29 to to TO cord-337849-tyabf12r 102 30 induce induce VB cord-337849-tyabf12r 102 31 a a DT cord-337849-tyabf12r 102 32 dose dose NN cord-337849-tyabf12r 102 33 - - HYPH cord-337849-tyabf12r 102 34 dependent dependent JJ cord-337849-tyabf12r 102 35 increase increase NN cord-337849-tyabf12r 102 36 in in IN cord-337849-tyabf12r 102 37 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 102 38 mRNA mRNA NNP cord-337849-tyabf12r 102 39 and and CC cord-337849-tyabf12r 102 40 protein protein NN cord-337849-tyabf12r 102 41 expression expression NN cord-337849-tyabf12r 102 42 in in IN cord-337849-tyabf12r 102 43 macrophages macrophage NNS cord-337849-tyabf12r 102 44 [ [ -LRB- cord-337849-tyabf12r 102 45 92 92 CD cord-337849-tyabf12r 102 46 ] ] -RRB- cord-337849-tyabf12r 102 47 . . . cord-337849-tyabf12r 103 1 Similarly similarly RB cord-337849-tyabf12r 103 2 , , , cord-337849-tyabf12r 103 3 ligation ligation NN cord-337849-tyabf12r 103 4 of of IN cord-337849-tyabf12r 103 5 TLR4 TLR4 NNP cord-337849-tyabf12r 103 6 by by IN cord-337849-tyabf12r 103 7 LPS LPS NNP cord-337849-tyabf12r 103 8 up up RB cord-337849-tyabf12r 103 9 - - HYPH cord-337849-tyabf12r 103 10 regulated regulate VBN cord-337849-tyabf12r 103 11 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 103 12 expression expression NN cord-337849-tyabf12r 103 13 in in IN cord-337849-tyabf12r 103 14 monocytes monocyte NNS cord-337849-tyabf12r 103 15 [ [ -LRB- cord-337849-tyabf12r 103 16 93 93 CD cord-337849-tyabf12r 103 17 , , , cord-337849-tyabf12r 103 18 94 94 CD cord-337849-tyabf12r 103 19 ] ] -RRB- cord-337849-tyabf12r 103 20 . . . cord-337849-tyabf12r 104 1 In in IN cord-337849-tyabf12r 104 2 dendritic dendritic JJ cord-337849-tyabf12r 104 3 cells cell NNS cord-337849-tyabf12r 104 4 , , , cord-337849-tyabf12r 104 5 ligation ligation NN cord-337849-tyabf12r 104 6 of of IN cord-337849-tyabf12r 104 7 TLR4 TLR4 NNP cord-337849-tyabf12r 104 8 by by IN cord-337849-tyabf12r 104 9 LPS LPS NNP cord-337849-tyabf12r 104 10 or or CC cord-337849-tyabf12r 104 11 monophosphoryl monophosphoryl NNP cord-337849-tyabf12r 104 12 lipid lipid VBG cord-337849-tyabf12r 104 13 A A NNP cord-337849-tyabf12r 104 14 ( ( -LRB- cord-337849-tyabf12r 104 15 MPLA MPLA NNP cord-337849-tyabf12r 104 16 ) ) -RRB- cord-337849-tyabf12r 104 17 , , , cord-337849-tyabf12r 104 18 and and CC cord-337849-tyabf12r 104 19 ligation ligation NN cord-337849-tyabf12r 104 20 of of IN cord-337849-tyabf12r 104 21 TLR3 TLR3 NNP cord-337849-tyabf12r 104 22 by by IN cord-337849-tyabf12r 104 23 polyI polyI NNP cord-337849-tyabf12r 104 24 : : : cord-337849-tyabf12r 105 1 C C NNP cord-337849-tyabf12r 105 2 induced induce VBD cord-337849-tyabf12r 105 3 expression expression NN cord-337849-tyabf12r 105 4 of of IN cord-337849-tyabf12r 105 5 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 105 6 , , , cord-337849-tyabf12r 105 7 altering alter VBG cord-337849-tyabf12r 105 8 DC DC NNP cord-337849-tyabf12r 105 9 migratory migratory JJ cord-337849-tyabf12r 105 10 properties property NNS cord-337849-tyabf12r 105 11 to to TO cord-337849-tyabf12r 105 12 allow allow VB cord-337849-tyabf12r 105 13 their -PRON- PRP$ cord-337849-tyabf12r 105 14 localisation localisation NN cord-337849-tyabf12r 105 15 into into IN cord-337849-tyabf12r 105 16 non non JJ cord-337849-tyabf12r 105 17 - - JJ cord-337849-tyabf12r 105 18 draining draining JJ cord-337849-tyabf12r 105 19 secondary secondary JJ cord-337849-tyabf12r 105 20 lymphoid lymphoid JJ cord-337849-tyabf12r 105 21 organs organ NNS cord-337849-tyabf12r 105 22 to to TO cord-337849-tyabf12r 105 23 present present VB cord-337849-tyabf12r 105 24 antigen antigen NN cord-337849-tyabf12r 105 25 peptides peptide NNS cord-337849-tyabf12r 105 26 to to IN cord-337849-tyabf12r 105 27 CD4 CD4 NNP cord-337849-tyabf12r 105 28 + + CC cord-337849-tyabf12r 105 29 T T NNP cord-337849-tyabf12r 105 30 - - HYPH cord-337849-tyabf12r 105 31 cells cell NNS cord-337849-tyabf12r 105 32 [ [ -LRB- cord-337849-tyabf12r 105 33 79 79 CD cord-337849-tyabf12r 105 34 , , , cord-337849-tyabf12r 105 35 [ [ -LRB- cord-337849-tyabf12r 105 36 95 95 CD cord-337849-tyabf12r 105 37 ] ] -RRB- cord-337849-tyabf12r 106 1 [ [ -LRB- cord-337849-tyabf12r 106 2 96 96 CD cord-337849-tyabf12r 106 3 ] ] -RRB- cord-337849-tyabf12r 106 4 [ [ -LRB- cord-337849-tyabf12r 106 5 97 97 CD cord-337849-tyabf12r 106 6 ] ] -RRB- cord-337849-tyabf12r 106 7 . . . cord-337849-tyabf12r 107 1 Similarly similarly RB cord-337849-tyabf12r 107 2 , , , cord-337849-tyabf12r 107 3 in in IN cord-337849-tyabf12r 107 4 human human JJ cord-337849-tyabf12r 107 5 tracheobronchial tracheobronchial JJ cord-337849-tyabf12r 107 6 epithelial epithelial NN cord-337849-tyabf12r 107 7 ( ( -LRB- cord-337849-tyabf12r 107 8 hTBE htbe NN cord-337849-tyabf12r 107 9 ) ) -RRB- cord-337849-tyabf12r 107 10 cells cell NNS cord-337849-tyabf12r 107 11 , , , cord-337849-tyabf12r 107 12 polyI polyI NNP cord-337849-tyabf12r 107 13 : : : cord-337849-tyabf12r 108 1 C c NN cord-337849-tyabf12r 108 2 stimulation stimulation NN cord-337849-tyabf12r 108 3 and and CC cord-337849-tyabf12r 108 4 addition addition NN cord-337849-tyabf12r 108 5 of of IN cord-337849-tyabf12r 108 6 live live JJ cord-337849-tyabf12r 108 7 RSV RSV NNP cord-337849-tyabf12r 108 8 were be VBD cord-337849-tyabf12r 108 9 demonstrated demonstrate VBN cord-337849-tyabf12r 108 10 to to TO cord-337849-tyabf12r 108 11 increase increase VB cord-337849-tyabf12r 108 12 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 108 13 expression expression NN cord-337849-tyabf12r 108 14 , , , cord-337849-tyabf12r 108 15 enhance enhance VB cord-337849-tyabf12r 108 16 25(OH)D 25(oh)d CD cord-337849-tyabf12r 108 17 conversion conversion NN cord-337849-tyabf12r 108 18 to to IN cord-337849-tyabf12r 108 19 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 108 20 , , , cord-337849-tyabf12r 108 21 and and CC cord-337849-tyabf12r 108 22 amplify amplify VB cord-337849-tyabf12r 108 23 cathelicidin cathelicidin NNP cord-337849-tyabf12r 109 1 mRNA mRNA NNP cord-337849-tyabf12r 109 2 [ [ -LRB- cord-337849-tyabf12r 109 3 98 98 CD cord-337849-tyabf12r 109 4 ] ] -RRB- cord-337849-tyabf12r 109 5 . . . cord-337849-tyabf12r 110 1 With with IN cord-337849-tyabf12r 110 2 the the DT cord-337849-tyabf12r 110 3 expression expression NN cord-337849-tyabf12r 110 4 of of IN cord-337849-tyabf12r 110 5 TLRs TLRs NNP cord-337849-tyabf12r 110 6 in in IN cord-337849-tyabf12r 110 7 multiple multiple JJ cord-337849-tyabf12r 110 8 cell cell NN cord-337849-tyabf12r 110 9 types type NNS cord-337849-tyabf12r 110 10 , , , cord-337849-tyabf12r 110 11 and and CC cord-337849-tyabf12r 110 12 the the DT cord-337849-tyabf12r 110 13 ability ability NN cord-337849-tyabf12r 110 14 to to TO cord-337849-tyabf12r 110 15 respond respond VB cord-337849-tyabf12r 110 16 to to IN cord-337849-tyabf12r 110 17 a a DT cord-337849-tyabf12r 110 18 variety variety NN cord-337849-tyabf12r 110 19 of of IN cord-337849-tyabf12r 110 20 pathogens pathogen NNS cord-337849-tyabf12r 110 21 , , , cord-337849-tyabf12r 110 22 it -PRON- PRP cord-337849-tyabf12r 110 23 is be VBZ cord-337849-tyabf12r 110 24 also also RB cord-337849-tyabf12r 110 25 possible possible JJ cord-337849-tyabf12r 110 26 that that IN cord-337849-tyabf12r 110 27 other other JJ cord-337849-tyabf12r 110 28 TLRs tlr NNS cord-337849-tyabf12r 110 29 or or CC cord-337849-tyabf12r 110 30 alternate alternate JJ cord-337849-tyabf12r 110 31 PRRs prr NNS cord-337849-tyabf12r 110 32 may may MD cord-337849-tyabf12r 110 33 promote promote VB cord-337849-tyabf12r 110 34 extra extra JJ cord-337849-tyabf12r 110 35 - - JJ cord-337849-tyabf12r 110 36 renal renal JJ cord-337849-tyabf12r 110 37 expression expression NN cord-337849-tyabf12r 110 38 of of IN cord-337849-tyabf12r 110 39 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 110 40 , , , cord-337849-tyabf12r 110 41 allowing allow VBG cord-337849-tyabf12r 110 42 locally locally RB cord-337849-tyabf12r 110 43 generated generate VBN cord-337849-tyabf12r 110 44 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 110 45 to to TO cord-337849-tyabf12r 110 46 have have VB cord-337849-tyabf12r 110 47 even even RB cord-337849-tyabf12r 110 48 more more RBR cord-337849-tyabf12r 110 49 extensive extensive JJ cord-337849-tyabf12r 110 50 effects effect NNS cord-337849-tyabf12r 110 51 on on IN cord-337849-tyabf12r 110 52 the the DT cord-337849-tyabf12r 110 53 immune immune JJ cord-337849-tyabf12r 110 54 response response NN cord-337849-tyabf12r 110 55 . . . cord-337849-tyabf12r 111 1 The the DT cord-337849-tyabf12r 111 2 exact exact JJ cord-337849-tyabf12r 111 3 mechanism mechanism NN cord-337849-tyabf12r 111 4 by by IN cord-337849-tyabf12r 111 5 which which WDT cord-337849-tyabf12r 111 6 TLR TLR NNP cord-337849-tyabf12r 111 7 ligation ligation NN cord-337849-tyabf12r 111 8 enhances enhance VBZ cord-337849-tyabf12r 111 9 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 111 10 production production NN cord-337849-tyabf12r 111 11 has have VBZ cord-337849-tyabf12r 111 12 not not RB cord-337849-tyabf12r 111 13 been be VBN cord-337849-tyabf12r 111 14 fully fully RB cord-337849-tyabf12r 111 15 defined define VBN cord-337849-tyabf12r 111 16 , , , cord-337849-tyabf12r 111 17 although although IN cord-337849-tyabf12r 111 18 the the DT cord-337849-tyabf12r 111 19 JAK JAK NNP cord-337849-tyabf12r 111 20 - - HYPH cord-337849-tyabf12r 111 21 STAT STAT NNP cord-337849-tyabf12r 111 22 , , , cord-337849-tyabf12r 111 23 NF nf NN cord-337849-tyabf12r 111 24 - - HYPH cord-337849-tyabf12r 111 25 κB κB NNP cord-337849-tyabf12r 111 26 and and CC cord-337849-tyabf12r 111 27 p38 p38 CD cord-337849-tyabf12r 111 28 MAPK MAPK NNP cord-337849-tyabf12r 111 29 pathways pathway NNS cord-337849-tyabf12r 111 30 , , , cord-337849-tyabf12r 111 31 and and CC cord-337849-tyabf12r 111 32 phosphorylation phosphorylation NN cord-337849-tyabf12r 111 33 of of IN cord-337849-tyabf12r 111 34 the the DT cord-337849-tyabf12r 111 35 transcription transcription NN cord-337849-tyabf12r 111 36 factor factor NN cord-337849-tyabf12r 112 1 C C NNP cord-337849-tyabf12r 112 2 / / SYM cord-337849-tyabf12r 112 3 EBPβ EBPβ NNS cord-337849-tyabf12r 112 4 by by IN cord-337849-tyabf12r 112 5 p38 p38 CD cord-337849-tyabf12r 112 6 MAPK MAPK NNP cord-337849-tyabf12r 112 7 have have VBP cord-337849-tyabf12r 112 8 been be VBN cord-337849-tyabf12r 112 9 implicated implicate VBN cord-337849-tyabf12r 112 10 [ [ -LRB- cord-337849-tyabf12r 112 11 94 94 CD cord-337849-tyabf12r 112 12 ] ] -RRB- cord-337849-tyabf12r 112 13 . . . cord-337849-tyabf12r 113 1 Additionally additionally RB cord-337849-tyabf12r 113 2 , , , cord-337849-tyabf12r 113 3 IL-15 IL-15 NNP cord-337849-tyabf12r 113 4 has have VBZ cord-337849-tyabf12r 113 5 been be VBN cord-337849-tyabf12r 113 6 demonstrated demonstrate VBN cord-337849-tyabf12r 113 7 to to TO cord-337849-tyabf12r 113 8 act act VB cord-337849-tyabf12r 113 9 as as IN cord-337849-tyabf12r 113 10 an an DT cord-337849-tyabf12r 113 11 intermediary intermediary NN cord-337849-tyabf12r 113 12 in in IN cord-337849-tyabf12r 113 13 promoting promote VBG cord-337849-tyabf12r 113 14 localized localized JJ cord-337849-tyabf12r 113 15 activity activity NN cord-337849-tyabf12r 113 16 of of IN cord-337849-tyabf12r 113 17 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 113 18 and and CC cord-337849-tyabf12r 113 19 synthesis synthesis NN cord-337849-tyabf12r 113 20 of of IN cord-337849-tyabf12r 113 21 1,25(OH)2D. 1,25(oh)2d. CD cord-337849-tyabf12r 113 22 TLR TLR NNP cord-337849-tyabf12r 113 23 2/1 2/1 CD cord-337849-tyabf12r 113 24 ligation ligation NN cord-337849-tyabf12r 113 25 by by IN cord-337849-tyabf12r 113 26 a a DT cord-337849-tyabf12r 113 27 triacylated triacylated JJ cord-337849-tyabf12r 113 28 lipopeptide lipopeptide NN cord-337849-tyabf12r 113 29 of of IN cord-337849-tyabf12r 113 30 the the DT cord-337849-tyabf12r 113 31 M.tuberculosis M.tuberculosis NNP cord-337849-tyabf12r 113 32 19 19 CD cord-337849-tyabf12r 113 33 kDa kDa NNS cord-337849-tyabf12r 113 34 antigen antigen NN cord-337849-tyabf12r 113 35 in in IN cord-337849-tyabf12r 113 36 human human JJ cord-337849-tyabf12r 113 37 monocytes monocyte NNS cord-337849-tyabf12r 113 38 induced induce VBN cord-337849-tyabf12r 113 39 IL-15 IL-15 NNP cord-337849-tyabf12r 113 40 secretion secretion NN cord-337849-tyabf12r 113 41 , , , cord-337849-tyabf12r 113 42 which which WDT cord-337849-tyabf12r 113 43 was be VBD cord-337849-tyabf12r 113 44 required require VBN cord-337849-tyabf12r 113 45 for for IN cord-337849-tyabf12r 113 46 the the DT cord-337849-tyabf12r 113 47 upregulation upregulation NN cord-337849-tyabf12r 113 48 of of IN cord-337849-tyabf12r 113 49 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 113 50 and and CC cord-337849-tyabf12r 113 51 the the DT cord-337849-tyabf12r 113 52 VDR VDR NNP cord-337849-tyabf12r 113 53 , , , cord-337849-tyabf12r 113 54 and and CC cord-337849-tyabf12r 113 55 subsequent subsequent JJ cord-337849-tyabf12r 113 56 downstream downstream JJ cord-337849-tyabf12r 113 57 production production NN cord-337849-tyabf12r 113 58 of of IN cord-337849-tyabf12r 113 59 LL-37 LL-37 NNP cord-337849-tyabf12r 113 60 [ [ -LRB- cord-337849-tyabf12r 113 61 99 99 CD cord-337849-tyabf12r 113 62 ] ] -RRB- cord-337849-tyabf12r 113 63 . . . cord-337849-tyabf12r 114 1 Other other JJ cord-337849-tyabf12r 114 2 cytokines cytokine NNS cord-337849-tyabf12r 114 3 , , , cord-337849-tyabf12r 114 4 such such JJ cord-337849-tyabf12r 114 5 as as IN cord-337849-tyabf12r 114 6 IL-13 IL-13 NNP cord-337849-tyabf12r 114 7 , , , cord-337849-tyabf12r 114 8 IFNγ IFNγ NNS cord-337849-tyabf12r 114 9 , , , cord-337849-tyabf12r 114 10 IL-4 IL-4 NNP cord-337849-tyabf12r 114 11 , , , cord-337849-tyabf12r 114 12 IL-1 IL-1 NNP cord-337849-tyabf12r 114 13 , , , cord-337849-tyabf12r 114 14 IL-2 IL-2 NNP cord-337849-tyabf12r 114 15 and and CC cord-337849-tyabf12r 114 16 TNF TNF NNP cord-337849-tyabf12r 114 17 - - HYPH cord-337849-tyabf12r 114 18 α α NNP cord-337849-tyabf12r 114 19 , , , cord-337849-tyabf12r 114 20 have have VBP cord-337849-tyabf12r 114 21 also also RB cord-337849-tyabf12r 114 22 been be VBN cord-337849-tyabf12r 114 23 implicated implicate VBN cord-337849-tyabf12r 114 24 as as IN cord-337849-tyabf12r 114 25 regulators regulator NNS cord-337849-tyabf12r 114 26 of of IN cord-337849-tyabf12r 114 27 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 114 28 expression expression NN cord-337849-tyabf12r 114 29 and and CC cord-337849-tyabf12r 114 30 vitamin vitamin NN cord-337849-tyabf12r 114 31 D d NN cord-337849-tyabf12r 114 32 metabolism metabolism NN cord-337849-tyabf12r 114 33 [ [ -LRB- cord-337849-tyabf12r 114 34 87 87 CD cord-337849-tyabf12r 114 35 , , , cord-337849-tyabf12r 114 36 94 94 CD cord-337849-tyabf12r 114 37 , , , cord-337849-tyabf12r 114 38 [ [ -LRB- cord-337849-tyabf12r 114 39 100 100 CD cord-337849-tyabf12r 114 40 ] ] -RRB- cord-337849-tyabf12r 114 41 [ [ -LRB- cord-337849-tyabf12r 114 42 101 101 CD cord-337849-tyabf12r 114 43 ] ] -RRB- cord-337849-tyabf12r 114 44 [ [ -LRB- cord-337849-tyabf12r 114 45 102 102 CD cord-337849-tyabf12r 114 46 ] ] -RRB- cord-337849-tyabf12r 114 47 [ [ -LRB- cord-337849-tyabf12r 114 48 103 103 CD cord-337849-tyabf12r 114 49 ] ] -RRB- cord-337849-tyabf12r 114 50 . . . cord-337849-tyabf12r 115 1 The the DT cord-337849-tyabf12r 115 2 pathways pathway NNS cord-337849-tyabf12r 115 3 involved involve VBN cord-337849-tyabf12r 115 4 in in IN cord-337849-tyabf12r 115 5 cytokine cytokine NN cord-337849-tyabf12r 115 6 - - HYPH cord-337849-tyabf12r 115 7 regulated regulated JJ cord-337849-tyabf12r 115 8 transcription transcription NN cord-337849-tyabf12r 115 9 of of IN cord-337849-tyabf12r 115 10 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 115 11 are be VBP cord-337849-tyabf12r 115 12 likely likely RB cord-337849-tyabf12r 115 13 the the DT cord-337849-tyabf12r 115 14 same same JJ cord-337849-tyabf12r 115 15 ones one NNS cord-337849-tyabf12r 115 16 as as IN cord-337849-tyabf12r 115 17 utilized utilize VBN cord-337849-tyabf12r 115 18 by by IN cord-337849-tyabf12r 115 19 TLR TLR NNP cord-337849-tyabf12r 115 20 ligation ligation NN cord-337849-tyabf12r 115 21 - - HYPH cord-337849-tyabf12r 115 22 induced induce VBN cord-337849-tyabf12r 115 23 regulation regulation NN cord-337849-tyabf12r 115 24 , , , cord-337849-tyabf12r 115 25 as as IN cord-337849-tyabf12r 115 26 described describe VBN cord-337849-tyabf12r 115 27 above above IN cord-337849-tyabf12r 115 28 [ [ -LRB- cord-337849-tyabf12r 115 29 101 101 CD cord-337849-tyabf12r 115 30 ] ] -RRB- cord-337849-tyabf12r 115 31 . . . cord-337849-tyabf12r 116 1 Therefore therefore RB cord-337849-tyabf12r 116 2 , , , cord-337849-tyabf12r 116 3 extra extra JJ cord-337849-tyabf12r 116 4 - - JJ cord-337849-tyabf12r 116 5 renal renal JJ cord-337849-tyabf12r 116 6 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 116 7 synthesis synthesis NN cord-337849-tyabf12r 116 8 has have VBZ cord-337849-tyabf12r 116 9 been be VBN cord-337849-tyabf12r 116 10 shown show VBN cord-337849-tyabf12r 116 11 to to TO cord-337849-tyabf12r 116 12 be be VB cord-337849-tyabf12r 116 13 regulated regulate VBN cord-337849-tyabf12r 116 14 by by IN cord-337849-tyabf12r 116 15 TLR TLR NNP cord-337849-tyabf12r 116 16 ligation ligation NN cord-337849-tyabf12r 116 17 and and CC cord-337849-tyabf12r 116 18 cytokine cytokine NN cord-337849-tyabf12r 116 19 secretion secretion NN cord-337849-tyabf12r 116 20 , , , cord-337849-tyabf12r 116 21 utilizing utilize VBG cord-337849-tyabf12r 116 22 an an DT cord-337849-tyabf12r 116 23 intricate intricate JJ cord-337849-tyabf12r 116 24 cross cross NN cord-337849-tyabf12r 116 25 - - NN cord-337849-tyabf12r 116 26 talk talk NN cord-337849-tyabf12r 116 27 between between IN cord-337849-tyabf12r 116 28 various various JJ cord-337849-tyabf12r 116 29 signalling signal VBG cord-337849-tyabf12r 116 30 pathways pathway NNS cord-337849-tyabf12r 116 31 . . . cord-337849-tyabf12r 117 1 As as IN cord-337849-tyabf12r 117 2 such such JJ cord-337849-tyabf12r 117 3 , , , cord-337849-tyabf12r 117 4 in in IN cord-337849-tyabf12r 117 5 the the DT cord-337849-tyabf12r 117 6 presence presence NN cord-337849-tyabf12r 117 7 of of IN cord-337849-tyabf12r 117 8 sufficient sufficient JJ cord-337849-tyabf12r 117 9 circulating circulate VBG cord-337849-tyabf12r 117 10 levels level NNS cord-337849-tyabf12r 117 11 of of IN cord-337849-tyabf12r 117 12 25(OH)D 25(oh)d CD cord-337849-tyabf12r 117 13 , , , cord-337849-tyabf12r 117 14 infection infection NN cord-337849-tyabf12r 117 15 by by IN cord-337849-tyabf12r 117 16 respiratory respiratory JJ cord-337849-tyabf12r 117 17 viruses virus NNS cord-337849-tyabf12r 117 18 resulting result VBG cord-337849-tyabf12r 117 19 in in IN cord-337849-tyabf12r 117 20 recognition recognition NN cord-337849-tyabf12r 117 21 by by IN cord-337849-tyabf12r 117 22 TLRs tlr NNS cord-337849-tyabf12r 117 23 and and CC cord-337849-tyabf12r 117 24 cytokine cytokine NN cord-337849-tyabf12r 117 25 production production NN cord-337849-tyabf12r 117 26 is be VBZ cord-337849-tyabf12r 117 27 able able JJ cord-337849-tyabf12r 117 28 to to TO cord-337849-tyabf12r 117 29 increase increase VB cord-337849-tyabf12r 117 30 levels level NNS cord-337849-tyabf12r 117 31 of of IN cord-337849-tyabf12r 117 32 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 117 33 , , , cord-337849-tyabf12r 117 34 hypothetically hypothetically RB cord-337849-tyabf12r 117 35 altering alter VBG cord-337849-tyabf12r 117 36 the the DT cord-337849-tyabf12r 117 37 immune immune JJ cord-337849-tyabf12r 117 38 response response NN cord-337849-tyabf12r 117 39 to to TO cord-337849-tyabf12r 117 40 better better RB cord-337849-tyabf12r 117 41 respond respond VB cord-337849-tyabf12r 117 42 to to IN cord-337849-tyabf12r 117 43 these these DT cord-337849-tyabf12r 117 44 pathogens pathogen NNS cord-337849-tyabf12r 117 45 . . . cord-337849-tyabf12r 118 1 [ [ -LRB- cord-337849-tyabf12r 118 2 104 104 CD cord-337849-tyabf12r 118 3 ] ] -RRB- cord-337849-tyabf12r 118 4 , , , cord-337849-tyabf12r 118 5 and and CC cord-337849-tyabf12r 118 6 Parton Parton NNP cord-337849-tyabf12r 118 7 and and CC cord-337849-tyabf12r 118 8 Simons Simons NNP cord-337849-tyabf12r 118 9 [ [ -LRB- cord-337849-tyabf12r 118 10 105 105 CD cord-337849-tyabf12r 118 11 ] ] -RRB- cord-337849-tyabf12r 118 12 ) ) -RRB- cord-337849-tyabf12r 118 13 . . . cord-337849-tyabf12r 119 1 Vitamin vitamin NN cord-337849-tyabf12r 119 2 D d NN cord-337849-tyabf12r 119 3 has have VBZ cord-337849-tyabf12r 119 4 diverse diverse JJ cord-337849-tyabf12r 119 5 and and CC cord-337849-tyabf12r 119 6 extensive extensive JJ cord-337849-tyabf12r 119 7 effects effect NNS cord-337849-tyabf12r 119 8 on on IN cord-337849-tyabf12r 119 9 the the DT cord-337849-tyabf12r 119 10 immune immune JJ cord-337849-tyabf12r 119 11 system system NN cord-337849-tyabf12r 119 12 , , , cord-337849-tyabf12r 119 13 due due IN cord-337849-tyabf12r 119 14 to to IN cord-337849-tyabf12r 119 15 the the DT cord-337849-tyabf12r 119 16 expression expression NN cord-337849-tyabf12r 119 17 of of IN cord-337849-tyabf12r 119 18 the the DT cord-337849-tyabf12r 119 19 VDR VDR NNP cord-337849-tyabf12r 119 20 and and CC cord-337849-tyabf12r 119 21 the the DT cord-337849-tyabf12r 119 22 enzyme enzyme NN cord-337849-tyabf12r 119 23 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 119 24 by by IN cord-337849-tyabf12r 119 25 most most JJS cord-337849-tyabf12r 119 26 immune immune JJ cord-337849-tyabf12r 119 27 cells cell NNS cord-337849-tyabf12r 119 28 [ [ -LRB- cord-337849-tyabf12r 119 29 11 11 CD cord-337849-tyabf12r 119 30 , , , cord-337849-tyabf12r 119 31 77 77 CD cord-337849-tyabf12r 119 32 , , , cord-337849-tyabf12r 119 33 81 81 CD cord-337849-tyabf12r 119 34 , , , cord-337849-tyabf12r 119 35 106 106 CD cord-337849-tyabf12r 119 36 ] ] -RRB- cord-337849-tyabf12r 119 37 . . . cord-337849-tyabf12r 120 1 The the DT cord-337849-tyabf12r 120 2 most most RBS cord-337849-tyabf12r 120 3 frequently frequently RB cord-337849-tyabf12r 120 4 demonstrated demonstrate VBN cord-337849-tyabf12r 120 5 effect effect NN cord-337849-tyabf12r 120 6 of of IN cord-337849-tyabf12r 120 7 vitamin vitamin NN cord-337849-tyabf12r 120 8 D d NN cord-337849-tyabf12r 120 9 is be VBZ cord-337849-tyabf12r 120 10 that that IN cord-337849-tyabf12r 120 11 on on IN cord-337849-tyabf12r 120 12 LL-37 LL-37 NNP cord-337849-tyabf12r 120 13 , , , cord-337849-tyabf12r 120 14 and and CC cord-337849-tyabf12r 120 15 , , , cord-337849-tyabf12r 120 16 as as IN cord-337849-tyabf12r 120 17 such such JJ cord-337849-tyabf12r 120 18 , , , cord-337849-tyabf12r 120 19 its -PRON- PRP$ cord-337849-tyabf12r 120 20 expression expression NN cord-337849-tyabf12r 120 21 is be VBZ cord-337849-tyabf12r 120 22 commonly commonly RB cord-337849-tyabf12r 120 23 used use VBN cord-337849-tyabf12r 120 24 to to TO cord-337849-tyabf12r 120 25 demonstrate demonstrate VB cord-337849-tyabf12r 120 26 increased increase VBN cord-337849-tyabf12r 120 27 CYP27B1 cyp27b1 NN cord-337849-tyabf12r 120 28 expression expression NN cord-337849-tyabf12r 120 29 and and CC cord-337849-tyabf12r 120 30 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 120 31 activity activity NN cord-337849-tyabf12r 120 32 . . . cord-337849-tyabf12r 121 1 Cathelicidins cathelicidin NNS cord-337849-tyabf12r 121 2 are be VBP cord-337849-tyabf12r 121 3 multifunctional multifunctional JJ cord-337849-tyabf12r 121 4 antimicrobial antimicrobial JJ cord-337849-tyabf12r 121 5 peptides peptide NNS cord-337849-tyabf12r 121 6 , , , cord-337849-tyabf12r 121 7 and and CC cord-337849-tyabf12r 121 8 the the DT cord-337849-tyabf12r 121 9 sole sole JJ cord-337849-tyabf12r 121 10 form form NN cord-337849-tyabf12r 121 11 in in IN cord-337849-tyabf12r 121 12 humans human NNS cord-337849-tyabf12r 121 13 is be VBZ cord-337849-tyabf12r 121 14 Human Human NNP cord-337849-tyabf12r 121 15 Cationic Cationic NNP cord-337849-tyabf12r 121 16 Antimicrobial Antimicrobial NNP cord-337849-tyabf12r 121 17 Peptide Peptide NNP cord-337849-tyabf12r 121 18 of of IN cord-337849-tyabf12r 121 19 18KDa 18kda CD cord-337849-tyabf12r 121 20 ( ( -LRB- cord-337849-tyabf12r 121 21 hCAP-18 hcap-18 ADD cord-337849-tyabf12r 121 22 ) ) -RRB- cord-337849-tyabf12r 121 23 . . . cord-337849-tyabf12r 122 1 From from IN cord-337849-tyabf12r 122 2 this this DT cord-337849-tyabf12r 122 3 precursor precursor NN cord-337849-tyabf12r 122 4 , , , cord-337849-tyabf12r 122 5 the the DT cord-337849-tyabf12r 122 6 active active JJ cord-337849-tyabf12r 122 7 form form NN cord-337849-tyabf12r 122 8 of of IN cord-337849-tyabf12r 122 9 LL-37 LL-37 NNP cord-337849-tyabf12r 122 10 is be VBZ cord-337849-tyabf12r 122 11 cleaved cleave VBN cord-337849-tyabf12r 122 12 by by IN cord-337849-tyabf12r 122 13 serine serine NN cord-337849-tyabf12r 122 14 protease protease NN cord-337849-tyabf12r 122 15 3 3 CD cord-337849-tyabf12r 122 16 in in IN cord-337849-tyabf12r 122 17 neutrophils neutrophil NNS cord-337849-tyabf12r 122 18 [ [ -LRB- cord-337849-tyabf12r 122 19 107 107 CD cord-337849-tyabf12r 122 20 ] ] -RRB- cord-337849-tyabf12r 122 21 . . . cord-337849-tyabf12r 123 1 While while IN cord-337849-tyabf12r 123 2 the the DT cord-337849-tyabf12r 123 3 method method NN cord-337849-tyabf12r 123 4 of of IN cord-337849-tyabf12r 123 5 cleavage cleavage NN cord-337849-tyabf12r 123 6 has have VBZ cord-337849-tyabf12r 123 7 not not RB cord-337849-tyabf12r 123 8 been be VBN cord-337849-tyabf12r 123 9 demonstrated demonstrate VBN cord-337849-tyabf12r 123 10 in in IN cord-337849-tyabf12r 123 11 other other JJ cord-337849-tyabf12r 123 12 cells cell NNS cord-337849-tyabf12r 123 13 types type NNS cord-337849-tyabf12r 123 14 , , , cord-337849-tyabf12r 123 15 LL-37 LL-37 NNP cord-337849-tyabf12r 123 16 has have VBZ cord-337849-tyabf12r 123 17 been be VBN cord-337849-tyabf12r 123 18 shown show VBN cord-337849-tyabf12r 123 19 to to TO cord-337849-tyabf12r 123 20 be be VB cord-337849-tyabf12r 123 21 present present JJ cord-337849-tyabf12r 123 22 in in IN cord-337849-tyabf12r 123 23 epithelial epithelial JJ cord-337849-tyabf12r 123 24 cells cell NNS cord-337849-tyabf12r 123 25 , , , cord-337849-tyabf12r 123 26 monocytes monocyte NNS cord-337849-tyabf12r 123 27 , , , cord-337849-tyabf12r 123 28 NK NK NNP cord-337849-tyabf12r 123 29 cells cell NNS cord-337849-tyabf12r 123 30 , , , cord-337849-tyabf12r 123 31 B b NN cord-337849-tyabf12r 123 32 - - HYPH cord-337849-tyabf12r 123 33 cells cell NNS cord-337849-tyabf12r 123 34 and and CC cord-337849-tyabf12r 123 35 γδ γδ IN cord-337849-tyabf12r 123 36 T T NNP cord-337849-tyabf12r 123 37 - - HYPH cord-337849-tyabf12r 123 38 cells cell NNS cord-337849-tyabf12r 123 39 [ [ -LRB- cord-337849-tyabf12r 123 40 56 56 CD cord-337849-tyabf12r 123 41 , , , cord-337849-tyabf12r 123 42 108 108 CD cord-337849-tyabf12r 123 43 ] ] -RRB- cord-337849-tyabf12r 123 44 , , , cord-337849-tyabf12r 123 45 and and CC cord-337849-tyabf12r 123 46 can can MD cord-337849-tyabf12r 123 47 be be VB cord-337849-tyabf12r 123 48 secreted secrete VBN cord-337849-tyabf12r 123 49 by by IN cord-337849-tyabf12r 123 50 respiratory respiratory JJ cord-337849-tyabf12r 123 51 epithelial epithelial JJ cord-337849-tyabf12r 123 52 cells cell NNS cord-337849-tyabf12r 123 53 onto onto IN cord-337849-tyabf12r 123 54 the the DT cord-337849-tyabf12r 123 55 airway airway NN cord-337849-tyabf12r 123 56 surface surface NN cord-337849-tyabf12r 123 57 to to TO cord-337849-tyabf12r 123 58 form form VB cord-337849-tyabf12r 123 59 a a DT cord-337849-tyabf12r 123 60 first first JJ cord-337849-tyabf12r 123 61 line line NN cord-337849-tyabf12r 123 62 of of IN cord-337849-tyabf12r 123 63 defence defence NN cord-337849-tyabf12r 123 64 against against IN cord-337849-tyabf12r 123 65 invading invade VBG cord-337849-tyabf12r 123 66 pathogens pathogen NNS cord-337849-tyabf12r 123 67 [ [ -LRB- cord-337849-tyabf12r 123 68 109 109 CD cord-337849-tyabf12r 123 69 ] ] -RRB- cord-337849-tyabf12r 123 70 . . . cord-337849-tyabf12r 124 1 It -PRON- PRP cord-337849-tyabf12r 124 2 has have VBZ cord-337849-tyabf12r 124 3 many many JJ cord-337849-tyabf12r 124 4 functions function NNS cord-337849-tyabf12r 124 5 , , , cord-337849-tyabf12r 124 6 as as IN cord-337849-tyabf12r 124 7 described describe VBN cord-337849-tyabf12r 124 8 elsewhere elsewhere RB cord-337849-tyabf12r 124 9 [ [ -LRB- cord-337849-tyabf12r 124 10 110 110 CD cord-337849-tyabf12r 124 11 ] ] -RRB- cord-337849-tyabf12r 124 12 [ [ -LRB- cord-337849-tyabf12r 124 13 111 111 CD cord-337849-tyabf12r 124 14 ] ] -RRB- cord-337849-tyabf12r 124 15 [ [ -LRB- cord-337849-tyabf12r 124 16 112 112 CD cord-337849-tyabf12r 124 17 ] ] -RRB- cord-337849-tyabf12r 124 18 [ [ -LRB- cord-337849-tyabf12r 124 19 113 113 CD cord-337849-tyabf12r 124 20 ] ] -RRB- cord-337849-tyabf12r 124 21 [ [ -LRB- cord-337849-tyabf12r 124 22 114 114 CD cord-337849-tyabf12r 124 23 ] ] -RRB- cord-337849-tyabf12r 124 24 [ [ -LRB- cord-337849-tyabf12r 124 25 115 115 CD cord-337849-tyabf12r 124 26 ] ] -RRB- cord-337849-tyabf12r 124 27 , , , cord-337849-tyabf12r 124 28 such such JJ cord-337849-tyabf12r 124 29 as as IN cord-337849-tyabf12r 124 30 direct direct JJ cord-337849-tyabf12r 124 31 facilitation facilitation NN cord-337849-tyabf12r 124 32 of of IN cord-337849-tyabf12r 124 33 chemotaxis chemotaxis NN cord-337849-tyabf12r 124 34 of of IN cord-337849-tyabf12r 124 35 immune immune JJ cord-337849-tyabf12r 124 36 cells cell NNS cord-337849-tyabf12r 124 37 and and CC cord-337849-tyabf12r 124 38 modification modification NN cord-337849-tyabf12r 124 39 of of IN cord-337849-tyabf12r 124 40 DC DC NNP cord-337849-tyabf12r 124 41 differentiation differentiation NN cord-337849-tyabf12r 124 42 , , , cord-337849-tyabf12r 124 43 and and CC cord-337849-tyabf12r 124 44 , , , cord-337849-tyabf12r 124 45 while while IN cord-337849-tyabf12r 124 46 traditionally traditionally RB cord-337849-tyabf12r 124 47 viewed view VBN cord-337849-tyabf12r 124 48 as as IN cord-337849-tyabf12r 124 49 a a DT cord-337849-tyabf12r 124 50 component component NN cord-337849-tyabf12r 124 51 of of IN cord-337849-tyabf12r 124 52 only only RB cord-337849-tyabf12r 124 53 the the DT cord-337849-tyabf12r 124 54 immune immune JJ cord-337849-tyabf12r 124 55 response response NN cord-337849-tyabf12r 124 56 to to IN cord-337849-tyabf12r 124 57 bacteria bacteria NNS cord-337849-tyabf12r 124 58 , , , cord-337849-tyabf12r 124 59 has have VBZ cord-337849-tyabf12r 124 60 also also RB cord-337849-tyabf12r 124 61 been be VBN cord-337849-tyabf12r 124 62 shown show VBN cord-337849-tyabf12r 124 63 to to TO cord-337849-tyabf12r 124 64 act act VB cord-337849-tyabf12r 124 65 directly directly RB cord-337849-tyabf12r 124 66 against against IN cord-337849-tyabf12r 124 67 viruses virus NNS cord-337849-tyabf12r 124 68 [ [ -LRB- cord-337849-tyabf12r 124 69 53 53 CD cord-337849-tyabf12r 124 70 , , , cord-337849-tyabf12r 124 71 54 54 CD cord-337849-tyabf12r 124 72 , , , cord-337849-tyabf12r 124 73 56 56 CD cord-337849-tyabf12r 124 74 ] ] -RRB- cord-337849-tyabf12r 124 75 . . . cord-337849-tyabf12r 125 1 Numerous numerous JJ cord-337849-tyabf12r 125 2 studies study NNS cord-337849-tyabf12r 125 3 have have VBP cord-337849-tyabf12r 125 4 demonstrated demonstrate VBN cord-337849-tyabf12r 125 5 the the DT cord-337849-tyabf12r 125 6 role role NN cord-337849-tyabf12r 125 7 the the DT cord-337849-tyabf12r 125 8 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 125 9 - - HYPH cord-337849-tyabf12r 125 10 ligated ligate VBN cord-337849-tyabf12r 125 11 VDR VDR NNP cord-337849-tyabf12r 125 12 plays play VBZ cord-337849-tyabf12r 125 13 in in IN cord-337849-tyabf12r 125 14 binding bind VBG cord-337849-tyabf12r 125 15 to to IN cord-337849-tyabf12r 125 16 a a DT cord-337849-tyabf12r 125 17 VDRE vdre NN cord-337849-tyabf12r 125 18 in in IN cord-337849-tyabf12r 125 19 the the DT cord-337849-tyabf12r 125 20 promoter promoter NN cord-337849-tyabf12r 125 21 of of IN cord-337849-tyabf12r 125 22 the the DT cord-337849-tyabf12r 125 23 cathelicidin cathelicidin NNP cord-337849-tyabf12r 125 24 gene gene NN cord-337849-tyabf12r 125 25 to to TO cord-337849-tyabf12r 125 26 enhance enhance VB cord-337849-tyabf12r 125 27 hCAP-18 hcap-18 CD cord-337849-tyabf12r 125 28 production production NN cord-337849-tyabf12r 125 29 [ [ -LRB- cord-337849-tyabf12r 125 30 116 116 CD cord-337849-tyabf12r 125 31 ] ] -RRB- cord-337849-tyabf12r 125 32 [ [ -LRB- cord-337849-tyabf12r 125 33 117 117 CD cord-337849-tyabf12r 125 34 ] ] -RRB- cord-337849-tyabf12r 125 35 [ [ -LRB- cord-337849-tyabf12r 125 36 118 118 CD cord-337849-tyabf12r 125 37 ] ] -RRB- cord-337849-tyabf12r 125 38 [ [ -LRB- cord-337849-tyabf12r 125 39 119 119 CD cord-337849-tyabf12r 125 40 ] ] -RRB- cord-337849-tyabf12r 125 41 , , , cord-337849-tyabf12r 125 42 thus thus RB cord-337849-tyabf12r 125 43 suggesting suggest VBG cord-337849-tyabf12r 125 44 a a DT cord-337849-tyabf12r 125 45 potential potential JJ cord-337849-tyabf12r 125 46 mechanism mechanism NN cord-337849-tyabf12r 125 47 by by IN cord-337849-tyabf12r 125 48 which which WDT cord-337849-tyabf12r 125 49 vitamin vitamin NN cord-337849-tyabf12r 125 50 D d NN cord-337849-tyabf12r 125 51 may may MD cord-337849-tyabf12r 125 52 enhance enhance VB cord-337849-tyabf12r 125 53 innate innate JJ cord-337849-tyabf12r 125 54 immunity immunity NN cord-337849-tyabf12r 125 55 to to IN cord-337849-tyabf12r 125 56 respiratory respiratory JJ cord-337849-tyabf12r 125 57 infections infection NNS cord-337849-tyabf12r 125 58 . . . cord-337849-tyabf12r 126 1 The the DT cord-337849-tyabf12r 126 2 proximal proximal JJ cord-337849-tyabf12r 126 3 promoter promoter NN cord-337849-tyabf12r 126 4 region region NN cord-337849-tyabf12r 126 5 of of IN cord-337849-tyabf12r 126 6 DEFB4 DEFB4 NNP cord-337849-tyabf12r 126 7 gene gene NN cord-337849-tyabf12r 126 8 also also RB cord-337849-tyabf12r 126 9 contains contain VBZ cord-337849-tyabf12r 126 10 a a DT cord-337849-tyabf12r 126 11 VDRE vdre NN cord-337849-tyabf12r 126 12 , , , cord-337849-tyabf12r 126 13 allowing allow VBG cord-337849-tyabf12r 126 14 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 126 15 to to TO cord-337849-tyabf12r 126 16 upregulate upregulate VB cord-337849-tyabf12r 126 17 expression expression NN cord-337849-tyabf12r 126 18 of of IN cord-337849-tyabf12r 126 19 β β NNP cord-337849-tyabf12r 126 20 - - HYPH cord-337849-tyabf12r 126 21 defensin defensin NNP cord-337849-tyabf12r 126 22 2 2 CD cord-337849-tyabf12r 126 23 [ [ -LRB- cord-337849-tyabf12r 126 24 116 116 CD cord-337849-tyabf12r 126 25 ] ] -RRB- cord-337849-tyabf12r 126 26 . . . cord-337849-tyabf12r 127 1 This this DT cord-337849-tyabf12r 127 2 is be VBZ cord-337849-tyabf12r 127 3 another another DT cord-337849-tyabf12r 127 4 antimicrobial antimicrobial JJ cord-337849-tyabf12r 127 5 peptide peptide NN cord-337849-tyabf12r 127 6 , , , cord-337849-tyabf12r 127 7 which which WDT cord-337849-tyabf12r 127 8 , , , cord-337849-tyabf12r 127 9 similarly similarly RB cord-337849-tyabf12r 127 10 to to IN cord-337849-tyabf12r 127 11 LL-37 LL-37 NNP cord-337849-tyabf12r 127 12 , , , cord-337849-tyabf12r 127 13 is be VBZ cord-337849-tyabf12r 127 14 able able JJ cord-337849-tyabf12r 127 15 to to TO cord-337849-tyabf12r 127 16 induce induce VB cord-337849-tyabf12r 127 17 chemotaxis chemotaxis NN cord-337849-tyabf12r 127 18 of of IN cord-337849-tyabf12r 127 19 immune immune JJ cord-337849-tyabf12r 127 20 cells cell NNS cord-337849-tyabf12r 127 21 and and CC cord-337849-tyabf12r 127 22 has have VBZ cord-337849-tyabf12r 127 23 been be VBN cord-337849-tyabf12r 127 24 shown show VBN cord-337849-tyabf12r 127 25 to to TO cord-337849-tyabf12r 127 26 inhibit inhibit VB cord-337849-tyabf12r 127 27 RSV RSV NNP cord-337849-tyabf12r 127 28 infection infection NN cord-337849-tyabf12r 127 29 [ [ -LRB- cord-337849-tyabf12r 127 30 120 120 CD cord-337849-tyabf12r 127 31 , , , cord-337849-tyabf12r 127 32 121 121 CD cord-337849-tyabf12r 127 33 ] ] -RRB- cord-337849-tyabf12r 127 34 . . . cord-337849-tyabf12r 128 1 In in IN cord-337849-tyabf12r 128 2 addition addition NN cord-337849-tyabf12r 128 3 to to IN cord-337849-tyabf12r 128 4 antimicrobial antimicrobial JJ cord-337849-tyabf12r 128 5 peptide peptide NN cord-337849-tyabf12r 128 6 induction induction NN cord-337849-tyabf12r 128 7 , , , cord-337849-tyabf12r 128 8 vitamin vitamin NN cord-337849-tyabf12r 128 9 D d NN cord-337849-tyabf12r 128 10 has have VBZ cord-337849-tyabf12r 128 11 been be VBN cord-337849-tyabf12r 128 12 demonstrated demonstrate VBN cord-337849-tyabf12r 128 13 to to TO cord-337849-tyabf12r 128 14 modulate modulate VB cord-337849-tyabf12r 128 15 the the DT cord-337849-tyabf12r 128 16 innate innate JJ cord-337849-tyabf12r 128 17 immune immune JJ cord-337849-tyabf12r 128 18 system system NN cord-337849-tyabf12r 128 19 in in IN cord-337849-tyabf12r 128 20 a a DT cord-337849-tyabf12r 128 21 variety variety NN cord-337849-tyabf12r 128 22 of of IN cord-337849-tyabf12r 128 23 other other JJ cord-337849-tyabf12r 128 24 ways way NNS cord-337849-tyabf12r 128 25 . . . cord-337849-tyabf12r 129 1 Monocyte Monocyte NNP cord-337849-tyabf12r 129 2 differentiation differentiation NN cord-337849-tyabf12r 129 3 into into IN cord-337849-tyabf12r 129 4 macrophages macrophage NNS cord-337849-tyabf12r 129 5 is be VBZ cord-337849-tyabf12r 129 6 induced induce VBN cord-337849-tyabf12r 129 7 [ [ -LRB- cord-337849-tyabf12r 129 8 122 122 CD cord-337849-tyabf12r 129 9 ] ] -RRB- cord-337849-tyabf12r 129 10 , , , cord-337849-tyabf12r 129 11 with with IN cord-337849-tyabf12r 129 12 enhancement enhancement NN cord-337849-tyabf12r 129 13 of of IN cord-337849-tyabf12r 129 14 the the DT cord-337849-tyabf12r 129 15 phagocytic phagocytic JJ cord-337849-tyabf12r 129 16 and and CC cord-337849-tyabf12r 129 17 chemotactic chemotactic JJ cord-337849-tyabf12r 129 18 capacity capacity NN cord-337849-tyabf12r 129 19 of of IN cord-337849-tyabf12r 129 20 macrophages macrophage NNS cord-337849-tyabf12r 129 21 [ [ -LRB- cord-337849-tyabf12r 129 22 11 11 CD cord-337849-tyabf12r 129 23 , , , cord-337849-tyabf12r 129 24 123 123 CD cord-337849-tyabf12r 129 25 ] ] -RRB- cord-337849-tyabf12r 129 26 , , , cord-337849-tyabf12r 129 27 thus thus RB cord-337849-tyabf12r 129 28 facilitating facilitate VBG cord-337849-tyabf12r 129 29 efferocytosis efferocytosis NN cord-337849-tyabf12r 129 30 and and CC cord-337849-tyabf12r 129 31 preventing prevent VBG cord-337849-tyabf12r 129 32 immunopathology immunopathology NN cord-337849-tyabf12r 129 33 . . . cord-337849-tyabf12r 130 1 One one CD cord-337849-tyabf12r 130 2 of of IN cord-337849-tyabf12r 130 3 the the DT cord-337849-tyabf12r 130 4 signalling signal VBG cord-337849-tyabf12r 130 5 pathways pathway NNS cord-337849-tyabf12r 130 6 regulated regulate VBN cord-337849-tyabf12r 130 7 by by IN cord-337849-tyabf12r 130 8 vitamin vitamin NN cord-337849-tyabf12r 130 9 D d NN cord-337849-tyabf12r 130 10 is be VBZ cord-337849-tyabf12r 130 11 the the DT cord-337849-tyabf12r 130 12 class class NN cord-337849-tyabf12r 130 13 III iii CD cord-337849-tyabf12r 130 14 phosphatidylinositol phosphatidylinositol JJ cord-337849-tyabf12r 130 15 3-kinase 3-kinase CD cord-337849-tyabf12r 130 16 complex complex NN cord-337849-tyabf12r 130 17 ( ( -LRB- cord-337849-tyabf12r 130 18 PI3KC3 pi3kc3 NN cord-337849-tyabf12r 130 19 ) ) -RRB- cord-337849-tyabf12r 130 20 , , , cord-337849-tyabf12r 130 21 with with IN cord-337849-tyabf12r 130 22 PI3 PI3 NNP cord-337849-tyabf12r 130 23 K K NNP cord-337849-tyabf12r 130 24 signalling signalling NN cord-337849-tyabf12r 130 25 associated associate VBN cord-337849-tyabf12r 130 26 with with IN cord-337849-tyabf12r 130 27 monocyte monocyte NNP cord-337849-tyabf12r 130 28 and and CC cord-337849-tyabf12r 130 29 macrophage macrophage NN cord-337849-tyabf12r 130 30 generation generation NN cord-337849-tyabf12r 130 31 of of IN cord-337849-tyabf12r 130 32 ROS ROS NNP cord-337849-tyabf12r 130 33 and and CC cord-337849-tyabf12r 130 34 iNOS ino VBD cord-337849-tyabf12r 130 35 [ [ -LRB- cord-337849-tyabf12r 130 36 124 124 CD cord-337849-tyabf12r 130 37 , , , cord-337849-tyabf12r 130 38 125 125 CD cord-337849-tyabf12r 130 39 ] ] -RRB- cord-337849-tyabf12r 130 40 . . . cord-337849-tyabf12r 131 1 The the DT cord-337849-tyabf12r 131 2 oxidative oxidative JJ cord-337849-tyabf12r 131 3 burst burst NN cord-337849-tyabf12r 131 4 has have VBZ cord-337849-tyabf12r 131 5 been be VBN cord-337849-tyabf12r 131 6 demonstrated demonstrate VBN cord-337849-tyabf12r 131 7 to to TO cord-337849-tyabf12r 131 8 have have VB cord-337849-tyabf12r 131 9 beneficial beneficial JJ cord-337849-tyabf12r 131 10 antiviral antiviral JJ cord-337849-tyabf12r 131 11 effects effect NNS cord-337849-tyabf12r 131 12 [ [ -LRB- cord-337849-tyabf12r 131 13 126 126 CD cord-337849-tyabf12r 131 14 ] ] -RRB- cord-337849-tyabf12r 131 15 [ [ -LRB- cord-337849-tyabf12r 131 16 127 127 CD cord-337849-tyabf12r 131 17 ] ] -RRB- cord-337849-tyabf12r 131 18 [ [ -LRB- cord-337849-tyabf12r 131 19 128 128 CD cord-337849-tyabf12r 131 20 ] ] -RRB- cord-337849-tyabf12r 131 21 [ [ -LRB- cord-337849-tyabf12r 131 22 129 129 CD cord-337849-tyabf12r 131 23 ] ] -RRB- cord-337849-tyabf12r 131 24 , , , cord-337849-tyabf12r 131 25 although although IN cord-337849-tyabf12r 131 26 aberrant aberrant JJ cord-337849-tyabf12r 131 27 induction induction NN cord-337849-tyabf12r 131 28 is be VBZ cord-337849-tyabf12r 131 29 associated associate VBN cord-337849-tyabf12r 131 30 with with IN cord-337849-tyabf12r 131 31 pathophysiology pathophysiology NN cord-337849-tyabf12r 131 32 and and CC cord-337849-tyabf12r 131 33 tissue tissue NN cord-337849-tyabf12r 131 34 damage damage NN cord-337849-tyabf12r 131 35 [ [ -LRB- cord-337849-tyabf12r 131 36 130 130 CD cord-337849-tyabf12r 131 37 ] ] -RRB- cord-337849-tyabf12r 131 38 [ [ -LRB- cord-337849-tyabf12r 131 39 131 131 CD cord-337849-tyabf12r 131 40 ] ] -RRB- cord-337849-tyabf12r 131 41 [ [ -LRB- cord-337849-tyabf12r 131 42 132 132 CD cord-337849-tyabf12r 131 43 ] ] -RRB- cord-337849-tyabf12r 131 44 . . . cord-337849-tyabf12r 132 1 As as IN cord-337849-tyabf12r 132 2 such such JJ cord-337849-tyabf12r 132 3 , , , cord-337849-tyabf12r 132 4 vitamin vitamin NN cord-337849-tyabf12r 132 5 D d NN cord-337849-tyabf12r 132 6 may may MD cord-337849-tyabf12r 132 7 have have VB cord-337849-tyabf12r 132 8 an an DT cord-337849-tyabf12r 132 9 important important JJ cord-337849-tyabf12r 132 10 role role NN cord-337849-tyabf12r 132 11 in in IN cord-337849-tyabf12r 132 12 redox redox JJ cord-337849-tyabf12r 132 13 homeostasis homeostasis NN cord-337849-tyabf12r 132 14 , , , cord-337849-tyabf12r 132 15 with with IN cord-337849-tyabf12r 132 16 evidence evidence NN cord-337849-tyabf12r 132 17 of of IN cord-337849-tyabf12r 132 18 both both CC cord-337849-tyabf12r 132 19 pro pro JJ cord-337849-tyabf12r 132 20 - - JJ cord-337849-tyabf12r 132 21 oxidative oxidative JJ cord-337849-tyabf12r 132 22 induction induction NN cord-337849-tyabf12r 132 23 of of IN cord-337849-tyabf12r 132 24 ROS ROS NNP cord-337849-tyabf12r 132 25 and and CC cord-337849-tyabf12r 132 26 iNOS ino VBD cord-337849-tyabf12r 132 27 to to TO cord-337849-tyabf12r 132 28 boost boost VB cord-337849-tyabf12r 132 29 the the DT cord-337849-tyabf12r 132 30 antiviral antiviral JJ cord-337849-tyabf12r 132 31 response response NN cord-337849-tyabf12r 132 32 [ [ -LRB- cord-337849-tyabf12r 132 33 125 125 CD cord-337849-tyabf12r 132 34 , , , cord-337849-tyabf12r 132 35 133 133 CD cord-337849-tyabf12r 132 36 ] ] -RRB- cord-337849-tyabf12r 132 37 , , , cord-337849-tyabf12r 132 38 and and CC cord-337849-tyabf12r 132 39 antioxidative antioxidative JJ cord-337849-tyabf12r 132 40 inhibition inhibition NN cord-337849-tyabf12r 132 41 of of IN cord-337849-tyabf12r 132 42 iNOS inos NN cord-337849-tyabf12r 132 43 and and CC cord-337849-tyabf12r 132 44 induction induction NN cord-337849-tyabf12r 132 45 of of IN cord-337849-tyabf12r 132 46 ROS ROS NNP cord-337849-tyabf12r 132 47 scavenging scavenging NN cord-337849-tyabf12r 132 48 pathways pathway NNS cord-337849-tyabf12r 132 49 to to TO cord-337849-tyabf12r 132 50 prevent prevent VB cord-337849-tyabf12r 132 51 immunopathology immunopathology NN cord-337849-tyabf12r 132 52 [ [ -LRB- cord-337849-tyabf12r 132 53 134 134 CD cord-337849-tyabf12r 132 54 ] ] -RRB- cord-337849-tyabf12r 132 55 [ [ -LRB- cord-337849-tyabf12r 132 56 135 135 CD cord-337849-tyabf12r 132 57 ] ] -RRB- cord-337849-tyabf12r 132 58 [ [ -LRB- cord-337849-tyabf12r 132 59 136 136 CD cord-337849-tyabf12r 132 60 ] ] -RRB- cord-337849-tyabf12r 132 61 . . . cord-337849-tyabf12r 133 1 The the DT cord-337849-tyabf12r 133 2 ability ability NN cord-337849-tyabf12r 133 3 of of IN cord-337849-tyabf12r 133 4 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 133 5 to to TO cord-337849-tyabf12r 133 6 induce induce VB cord-337849-tyabf12r 133 7 monocyte monocyte NNP cord-337849-tyabf12r 133 8 autophagy autophagy NN cord-337849-tyabf12r 133 9 has have VBZ cord-337849-tyabf12r 133 10 also also RB cord-337849-tyabf12r 133 11 been be VBN cord-337849-tyabf12r 133 12 demonstrated demonstrate VBN cord-337849-tyabf12r 133 13 . . . cord-337849-tyabf12r 134 1 Autophagy Autophagy NNP cord-337849-tyabf12r 134 2 acts act VBZ cord-337849-tyabf12r 134 3 as as IN cord-337849-tyabf12r 134 4 part part NN cord-337849-tyabf12r 134 5 of of IN cord-337849-tyabf12r 134 6 the the DT cord-337849-tyabf12r 134 7 immune immune JJ cord-337849-tyabf12r 134 8 system system NN cord-337849-tyabf12r 134 9 to to TO cord-337849-tyabf12r 134 10 remove remove VB cord-337849-tyabf12r 134 11 damaged damaged JJ cord-337849-tyabf12r 134 12 proteins protein NNS cord-337849-tyabf12r 134 13 and and CC cord-337849-tyabf12r 134 14 organelles organelle NNS cord-337849-tyabf12r 134 15 , , , cord-337849-tyabf12r 134 16 and and CC cord-337849-tyabf12r 134 17 is be VBZ cord-337849-tyabf12r 134 18 an an DT cord-337849-tyabf12r 134 19 important important JJ cord-337849-tyabf12r 134 20 host host NN cord-337849-tyabf12r 134 21 defence defence NN cord-337849-tyabf12r 134 22 mechanism mechanism NN cord-337849-tyabf12r 134 23 against against IN cord-337849-tyabf12r 134 24 viral viral JJ cord-337849-tyabf12r 134 25 infections infection NNS cord-337849-tyabf12r 134 26 [ [ -LRB- cord-337849-tyabf12r 134 27 137 137 CD cord-337849-tyabf12r 134 28 ] ] -RRB- cord-337849-tyabf12r 134 29 . . . cord-337849-tyabf12r 135 1 Vitamin vitamin NN cord-337849-tyabf12r 135 2 D d NN cord-337849-tyabf12r 135 3 has have VBZ cord-337849-tyabf12r 135 4 been be VBN cord-337849-tyabf12r 135 5 shown show VBN cord-337849-tyabf12r 135 6 to to TO cord-337849-tyabf12r 135 7 induce induce VB cord-337849-tyabf12r 135 8 autophagy autophagy NN cord-337849-tyabf12r 135 9 by by IN cord-337849-tyabf12r 135 10 regulating regulate VBG cord-337849-tyabf12r 135 11 multiple multiple JJ cord-337849-tyabf12r 135 12 associated associate VBN cord-337849-tyabf12r 135 13 pathways pathway NNS cord-337849-tyabf12r 135 14 , , , cord-337849-tyabf12r 135 15 such such JJ cord-337849-tyabf12r 135 16 as as IN cord-337849-tyabf12r 135 17 Bcl-2 Bcl-2 NNP cord-337849-tyabf12r 135 18 , , , cord-337849-tyabf12r 135 19 mammalian mammalian JJ cord-337849-tyabf12r 135 20 target target NN cord-337849-tyabf12r 135 21 of of IN cord-337849-tyabf12r 135 22 rapamycin rapamycin NNP cord-337849-tyabf12r 135 23 ( ( -LRB- cord-337849-tyabf12r 135 24 mTOR mTOR NNP cord-337849-tyabf12r 135 25 ) ) -RRB- cord-337849-tyabf12r 135 26 , , , cord-337849-tyabf12r 135 27 class class NN cord-337849-tyabf12r 135 28 III iii CD cord-337849-tyabf12r 135 29 phosphatidylinositol phosphatidylinositol JJ cord-337849-tyabf12r 135 30 3-kinase 3-kinase CD cord-337849-tyabf12r 135 31 complex complex NN cord-337849-tyabf12r 135 32 , , , cord-337849-tyabf12r 135 33 and and CC cord-337849-tyabf12r 135 34 cathelicidin cathelicidin NN cord-337849-tyabf12r 135 35 production production NN cord-337849-tyabf12r 135 36 , , , cord-337849-tyabf12r 135 37 thus thus RB cord-337849-tyabf12r 135 38 potentially potentially RB cord-337849-tyabf12r 135 39 enhancing enhance VBG cord-337849-tyabf12r 135 40 clearance clearance NN cord-337849-tyabf12r 135 41 of of IN cord-337849-tyabf12r 135 42 viruses virus NNS cord-337849-tyabf12r 135 43 and and CC cord-337849-tyabf12r 135 44 viral viral JJ cord-337849-tyabf12r 135 45 components component NNS cord-337849-tyabf12r 135 46 [ [ -LRB- cord-337849-tyabf12r 135 47 124 124 CD cord-337849-tyabf12r 135 48 , , , cord-337849-tyabf12r 135 49 138 138 CD cord-337849-tyabf12r 135 50 , , , cord-337849-tyabf12r 135 51 139 139 CD cord-337849-tyabf12r 135 52 ] ] -RRB- cord-337849-tyabf12r 135 53 . . . cord-337849-tyabf12r 136 1 Pattern pattern NN cord-337849-tyabf12r 136 2 recognition recognition NN cord-337849-tyabf12r 136 3 receptors receptor NNS cord-337849-tyabf12r 136 4 have have VBP cord-337849-tyabf12r 136 5 also also RB cord-337849-tyabf12r 136 6 been be VBN cord-337849-tyabf12r 136 7 demonstrated demonstrate VBN cord-337849-tyabf12r 136 8 to to TO cord-337849-tyabf12r 136 9 be be VB cord-337849-tyabf12r 136 10 regulated regulate VBN cord-337849-tyabf12r 136 11 by by IN cord-337849-tyabf12r 136 12 vitamin vitamin NN cord-337849-tyabf12r 136 13 D. D. NNP cord-337849-tyabf12r 136 14 Expression Expression NNP cord-337849-tyabf12r 136 15 of of IN cord-337849-tyabf12r 136 16 TLR2 TLR2 NNP cord-337849-tyabf12r 136 17 and and CC cord-337849-tyabf12r 136 18 TLR4 TLR4 NNP cord-337849-tyabf12r 136 19 is be VBZ cord-337849-tyabf12r 136 20 inhibited inhibit VBN cord-337849-tyabf12r 136 21 in in IN cord-337849-tyabf12r 136 22 monocytes monocyte NNS cord-337849-tyabf12r 136 23 , , , cord-337849-tyabf12r 136 24 resulting result VBG cord-337849-tyabf12r 136 25 in in IN cord-337849-tyabf12r 136 26 impaired impaired JJ cord-337849-tyabf12r 136 27 downstream downstream JJ cord-337849-tyabf12r 136 28 signalling signalling NN cord-337849-tyabf12r 136 29 and and CC cord-337849-tyabf12r 136 30 hyporesponsiveness hyporesponsiveness NN cord-337849-tyabf12r 136 31 to to IN cord-337849-tyabf12r 136 32 PAMPS PAMPS NNP cord-337849-tyabf12r 136 33 . . . cord-337849-tyabf12r 137 1 With with IN cord-337849-tyabf12r 137 2 the the DT cord-337849-tyabf12r 137 3 observation observation NN cord-337849-tyabf12r 137 4 that that IN cord-337849-tyabf12r 137 5 this this DT cord-337849-tyabf12r 137 6 effect effect NN cord-337849-tyabf12r 137 7 is be VBZ cord-337849-tyabf12r 137 8 most most RBS cord-337849-tyabf12r 137 9 prominent prominent JJ cord-337849-tyabf12r 137 10 after after IN cord-337849-tyabf12r 137 11 72 72 CD cord-337849-tyabf12r 137 12 h h NN cord-337849-tyabf12r 137 13 , , , cord-337849-tyabf12r 137 14 a a DT cord-337849-tyabf12r 137 15 negative negative JJ cord-337849-tyabf12r 137 16 feedback feedback NN cord-337849-tyabf12r 137 17 mechanism mechanism NN cord-337849-tyabf12r 137 18 has have VBZ cord-337849-tyabf12r 137 19 been be VBN cord-337849-tyabf12r 137 20 suggested suggest VBN cord-337849-tyabf12r 137 21 , , , cord-337849-tyabf12r 137 22 whereby whereby WRB cord-337849-tyabf12r 137 23 excessive excessive JJ cord-337849-tyabf12r 137 24 TLR TLR NNP cord-337849-tyabf12r 137 25 activation activation NN cord-337849-tyabf12r 137 26 is be VBZ cord-337849-tyabf12r 137 27 prevented prevent VBN cord-337849-tyabf12r 137 28 at at IN cord-337849-tyabf12r 137 29 later later JJ cord-337849-tyabf12r 137 30 stages stage NNS cord-337849-tyabf12r 137 31 of of IN cord-337849-tyabf12r 137 32 infection infection NN cord-337849-tyabf12r 137 33 to to TO cord-337849-tyabf12r 137 34 dampen dampen VB cord-337849-tyabf12r 137 35 inflammation inflammation NN cord-337849-tyabf12r 137 36 [ [ -LRB- cord-337849-tyabf12r 137 37 11 11 CD cord-337849-tyabf12r 137 38 , , , cord-337849-tyabf12r 137 39 140 140 CD cord-337849-tyabf12r 137 40 ] ] -RRB- cord-337849-tyabf12r 137 41 . . . cord-337849-tyabf12r 138 1 Conversely conversely RB cord-337849-tyabf12r 138 2 , , , cord-337849-tyabf12r 138 3 CD14 CD14 NNP cord-337849-tyabf12r 138 4 , , , cord-337849-tyabf12r 138 5 an an DT cord-337849-tyabf12r 138 6 accessory accessory NN cord-337849-tyabf12r 138 7 protein protein NN cord-337849-tyabf12r 138 8 to to IN cord-337849-tyabf12r 138 9 TLR4 TLR4 NNP cord-337849-tyabf12r 138 10 which which WDT cord-337849-tyabf12r 138 11 has have VBZ cord-337849-tyabf12r 138 12 also also RB cord-337849-tyabf12r 138 13 been be VBN cord-337849-tyabf12r 138 14 linked link VBN cord-337849-tyabf12r 138 15 to to IN cord-337849-tyabf12r 138 16 TLR2 TLR2 NNP cord-337849-tyabf12r 138 17 [ [ -LRB- cord-337849-tyabf12r 138 18 141 141 CD cord-337849-tyabf12r 138 19 ] ] -RRB- cord-337849-tyabf12r 138 20 , , , cord-337849-tyabf12r 138 21 was be VBD cord-337849-tyabf12r 138 22 up up RB cord-337849-tyabf12r 138 23 - - HYPH cord-337849-tyabf12r 138 24 regulated regulate VBN cord-337849-tyabf12r 138 25 by by IN cord-337849-tyabf12r 138 26 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 138 27 [ [ -LRB- cord-337849-tyabf12r 138 28 140 140 CD cord-337849-tyabf12r 138 29 , , , cord-337849-tyabf12r 138 30 142 142 CD cord-337849-tyabf12r 138 31 , , , cord-337849-tyabf12r 138 32 143 143 CD cord-337849-tyabf12r 138 33 ] ] -RRB- cord-337849-tyabf12r 138 34 , , , cord-337849-tyabf12r 138 35 but but CC cord-337849-tyabf12r 138 36 this this DT cord-337849-tyabf12r 138 37 effect effect NN cord-337849-tyabf12r 138 38 was be VBD cord-337849-tyabf12r 138 39 not not RB cord-337849-tyabf12r 138 40 sufficient sufficient JJ cord-337849-tyabf12r 138 41 to to TO cord-337849-tyabf12r 138 42 restore restore VB cord-337849-tyabf12r 138 43 downstream downstream JJ cord-337849-tyabf12r 138 44 TLR TLR NNP cord-337849-tyabf12r 138 45 signalling signal VBG cord-337849-tyabf12r 138 46 [ [ -LRB- cord-337849-tyabf12r 138 47 140 140 CD cord-337849-tyabf12r 138 48 ] ] -RRB- cord-337849-tyabf12r 138 49 . . . cord-337849-tyabf12r 139 1 Additionally additionally RB cord-337849-tyabf12r 139 2 , , , cord-337849-tyabf12r 139 3 as as IN cord-337849-tyabf12r 139 4 opposed oppose VBN cord-337849-tyabf12r 139 5 to to IN cord-337849-tyabf12r 139 6 its -PRON- PRP$ cord-337849-tyabf12r 139 7 effects effect NNS cord-337849-tyabf12r 139 8 in in IN cord-337849-tyabf12r 139 9 monocytes monocyte NNS cord-337849-tyabf12r 139 10 , , , cord-337849-tyabf12r 139 11 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 139 12 has have VBZ cord-337849-tyabf12r 139 13 been be VBN cord-337849-tyabf12r 139 14 demonstrated demonstrate VBN cord-337849-tyabf12r 139 15 to to TO cord-337849-tyabf12r 139 16 induce induce VB cord-337849-tyabf12r 139 17 up up RP cord-337849-tyabf12r 139 18 - - HYPH cord-337849-tyabf12r 139 19 regulation regulation NN cord-337849-tyabf12r 139 20 of of IN cord-337849-tyabf12r 139 21 TLR2 TLR2 NNP cord-337849-tyabf12r 139 22 in in IN cord-337849-tyabf12r 139 23 keratinocytes keratinocyte NNS cord-337849-tyabf12r 139 24 , , , cord-337849-tyabf12r 139 25 allowing allow VBG cord-337849-tyabf12r 139 26 a a DT cord-337849-tyabf12r 139 27 mechanism mechanism NN cord-337849-tyabf12r 139 28 by by IN cord-337849-tyabf12r 139 29 which which WDT cord-337849-tyabf12r 139 30 vitamin vitamin NN cord-337849-tyabf12r 139 31 D d NN cord-337849-tyabf12r 139 32 may may MD cord-337849-tyabf12r 139 33 prevent prevent VB cord-337849-tyabf12r 139 34 infection infection NN cord-337849-tyabf12r 139 35 of of IN cord-337849-tyabf12r 139 36 wounds wound NNS cord-337849-tyabf12r 139 37 [ [ -LRB- cord-337849-tyabf12r 139 38 144 144 CD cord-337849-tyabf12r 139 39 ] ] -RRB- cord-337849-tyabf12r 139 40 . . . cord-337849-tyabf12r 140 1 Finally finally RB cord-337849-tyabf12r 140 2 , , , cord-337849-tyabf12r 140 3 the the DT cord-337849-tyabf12r 140 4 intracellular intracellular JJ cord-337849-tyabf12r 140 5 receptor receptor NN cord-337849-tyabf12r 140 6 NOD2 NOD2 NNPS cord-337849-tyabf12r 140 7 is be VBZ cord-337849-tyabf12r 140 8 induced induce VBN cord-337849-tyabf12r 140 9 by by IN cord-337849-tyabf12r 140 10 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 140 11 in in IN cord-337849-tyabf12r 140 12 myeloid myeloid JJ cord-337849-tyabf12r 140 13 and and CC cord-337849-tyabf12r 140 14 epithelial epithelial JJ cord-337849-tyabf12r 140 15 cells cell NNS cord-337849-tyabf12r 140 16 , , , cord-337849-tyabf12r 140 17 via via IN cord-337849-tyabf12r 140 18 two two CD cord-337849-tyabf12r 140 19 distal distal JJ cord-337849-tyabf12r 140 20 VDREs vdre NNS cord-337849-tyabf12r 140 21 in in IN cord-337849-tyabf12r 140 22 the the DT cord-337849-tyabf12r 140 23 NOD2 NOD2 NNP cord-337849-tyabf12r 140 24 gene gene NN cord-337849-tyabf12r 140 25 . . . cord-337849-tyabf12r 141 1 Addition addition NN cord-337849-tyabf12r 141 2 of of IN cord-337849-tyabf12r 141 3 MDP MDP NNP cord-337849-tyabf12r 141 4 ( ( -LRB- cord-337849-tyabf12r 141 5 a a DT cord-337849-tyabf12r 141 6 lysosomal lysosomal JJ cord-337849-tyabf12r 141 7 breakdown breakdown NN cord-337849-tyabf12r 141 8 product product NN cord-337849-tyabf12r 141 9 of of IN cord-337849-tyabf12r 141 10 bacterial bacterial JJ cord-337849-tyabf12r 141 11 peptidoglycan peptidoglycan NN cord-337849-tyabf12r 141 12 [ [ -LRB- cord-337849-tyabf12r 141 13 11 11 CD cord-337849-tyabf12r 141 14 ] ] -RRB- cord-337849-tyabf12r 141 15 ) ) -RRB- cord-337849-tyabf12r 141 16 to to IN cord-337849-tyabf12r 141 17 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 141 18 - - HYPH cord-337849-tyabf12r 141 19 induced induce VBN cord-337849-tyabf12r 141 20 NOD2 NOD2 NNP cord-337849-tyabf12r 141 21 enhanced enhance VBD cord-337849-tyabf12r 141 22 NF NF NNP cord-337849-tyabf12r 141 23 - - HYPH cord-337849-tyabf12r 141 24 κB κB NNP cord-337849-tyabf12r 141 25 signalling signal VBG cord-337849-tyabf12r 141 26 and and CC cord-337849-tyabf12r 141 27 subsequent subsequent JJ cord-337849-tyabf12r 141 28 β β NNP cord-337849-tyabf12r 141 29 - - HYPH cord-337849-tyabf12r 141 30 defensin defensin NNP cord-337849-tyabf12r 141 31 2 2 CD cord-337849-tyabf12r 141 32 expression expression NN cord-337849-tyabf12r 141 33 [ [ -LRB- cord-337849-tyabf12r 141 34 145 145 CD cord-337849-tyabf12r 141 35 ] ] -RRB- cord-337849-tyabf12r 141 36 . . . cord-337849-tyabf12r 142 1 Vitamin vitamin NN cord-337849-tyabf12r 142 2 D d NN cord-337849-tyabf12r 142 3 also also RB cord-337849-tyabf12r 142 4 modulates modulate VBZ cord-337849-tyabf12r 142 5 the the DT cord-337849-tyabf12r 142 6 adaptive adaptive JJ cord-337849-tyabf12r 142 7 immune immune JJ cord-337849-tyabf12r 142 8 response response NN cord-337849-tyabf12r 142 9 , , , cord-337849-tyabf12r 142 10 and and CC cord-337849-tyabf12r 142 11 acts act VBZ cord-337849-tyabf12r 142 12 as as IN cord-337849-tyabf12r 142 13 a a DT cord-337849-tyabf12r 142 14 key key JJ cord-337849-tyabf12r 142 15 intermediary intermediary NN cord-337849-tyabf12r 142 16 between between IN cord-337849-tyabf12r 142 17 innate innate JJ cord-337849-tyabf12r 142 18 and and CC cord-337849-tyabf12r 142 19 adaptive adaptive JJ cord-337849-tyabf12r 142 20 immunity immunity NN cord-337849-tyabf12r 142 21 due due IN cord-337849-tyabf12r 142 22 to to IN cord-337849-tyabf12r 142 23 its -PRON- PRP$ cord-337849-tyabf12r 142 24 influence influence NN cord-337849-tyabf12r 142 25 on on IN cord-337849-tyabf12r 142 26 antigen antigen NN cord-337849-tyabf12r 142 27 presentation presentation NN cord-337849-tyabf12r 142 28 . . . cord-337849-tyabf12r 143 1 Dendritic dendritic JJ cord-337849-tyabf12r 143 2 cells cell NNS cord-337849-tyabf12r 143 3 are be VBP cord-337849-tyabf12r 143 4 the the DT cord-337849-tyabf12r 143 5 most most RBS cord-337849-tyabf12r 143 6 potent potent JJ cord-337849-tyabf12r 143 7 antigen antigen NN cord-337849-tyabf12r 143 8 - - HYPH cord-337849-tyabf12r 143 9 presenting present VBG cord-337849-tyabf12r 143 10 cells cell NNS cord-337849-tyabf12r 143 11 , , , cord-337849-tyabf12r 143 12 and and CC cord-337849-tyabf12r 143 13 , , , cord-337849-tyabf12r 143 14 as as IN cord-337849-tyabf12r 143 15 such such JJ cord-337849-tyabf12r 143 16 , , , cord-337849-tyabf12r 143 17 have have VBP cord-337849-tyabf12r 143 18 a a DT cord-337849-tyabf12r 143 19 direct direct JJ cord-337849-tyabf12r 143 20 effect effect NN cord-337849-tyabf12r 143 21 on on IN cord-337849-tyabf12r 143 22 lymphocyte lymphocyte NN cord-337849-tyabf12r 143 23 activation activation NN cord-337849-tyabf12r 143 24 and and CC cord-337849-tyabf12r 143 25 induction induction NN cord-337849-tyabf12r 143 26 of of IN cord-337849-tyabf12r 143 27 the the DT cord-337849-tyabf12r 143 28 adaptive adaptive JJ cord-337849-tyabf12r 143 29 immune immune JJ cord-337849-tyabf12r 143 30 response response NN cord-337849-tyabf12r 143 31 . . . cord-337849-tyabf12r 144 1 They -PRON- PRP cord-337849-tyabf12r 144 2 reside reside VBP cord-337849-tyabf12r 144 3 in in IN cord-337849-tyabf12r 144 4 peripheral peripheral JJ cord-337849-tyabf12r 144 5 tissues tissue NNS cord-337849-tyabf12r 144 6 in in IN cord-337849-tyabf12r 144 7 an an DT cord-337849-tyabf12r 144 8 immature immature JJ cord-337849-tyabf12r 144 9 state state NN cord-337849-tyabf12r 144 10 , , , cord-337849-tyabf12r 144 11 sampling sample VBG cord-337849-tyabf12r 144 12 the the DT cord-337849-tyabf12r 144 13 environment environment NN cord-337849-tyabf12r 144 14 and and CC cord-337849-tyabf12r 144 15 mediating mediate VBG cord-337849-tyabf12r 144 16 antigen antigen NN cord-337849-tyabf12r 144 17 uptake uptake NN cord-337849-tyabf12r 144 18 , , , cord-337849-tyabf12r 144 19 until until IN cord-337849-tyabf12r 144 20 a a DT cord-337849-tyabf12r 144 21 maturation maturation NN cord-337849-tyabf12r 144 22 signal signal NN cord-337849-tyabf12r 144 23 induces induce VBZ cord-337849-tyabf12r 144 24 migration migration NN cord-337849-tyabf12r 144 25 to to IN cord-337849-tyabf12r 144 26 local local JJ cord-337849-tyabf12r 144 27 lymph lymph NN cord-337849-tyabf12r 144 28 nodes node NNS cord-337849-tyabf12r 144 29 and and CC cord-337849-tyabf12r 144 30 subsequent subsequent JJ cord-337849-tyabf12r 144 31 T t NN cord-337849-tyabf12r 144 32 - - HYPH cord-337849-tyabf12r 144 33 cell cell NN cord-337849-tyabf12r 144 34 activation activation NN cord-337849-tyabf12r 144 35 . . . cord-337849-tyabf12r 145 1 Addition addition NN cord-337849-tyabf12r 145 2 of of IN cord-337849-tyabf12r 145 3 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 145 4 has have VBZ cord-337849-tyabf12r 145 5 been be VBN cord-337849-tyabf12r 145 6 demonstrated demonstrate VBN cord-337849-tyabf12r 145 7 to to TO cord-337849-tyabf12r 145 8 inhibit inhibit VB cord-337849-tyabf12r 145 9 DC DC NNP cord-337849-tyabf12r 145 10 differentiation differentiation NN cord-337849-tyabf12r 145 11 , , , cord-337849-tyabf12r 145 12 maturation maturation NN cord-337849-tyabf12r 145 13 and and CC cord-337849-tyabf12r 145 14 antigen antigen NN cord-337849-tyabf12r 145 15 presentation presentation NN cord-337849-tyabf12r 145 16 , , , cord-337849-tyabf12r 145 17 with with IN cord-337849-tyabf12r 145 18 an an DT cord-337849-tyabf12r 145 19 associated associate VBN cord-337849-tyabf12r 145 20 decrease decrease NN cord-337849-tyabf12r 145 21 in in IN cord-337849-tyabf12r 145 22 markers marker NNS cord-337849-tyabf12r 145 23 such such JJ cord-337849-tyabf12r 145 24 as as IN cord-337849-tyabf12r 145 25 CD1a CD1a NNP cord-337849-tyabf12r 145 26 , , , cord-337849-tyabf12r 145 27 MHC MHC NNP cord-337849-tyabf12r 145 28 class class NN cord-337849-tyabf12r 145 29 II II NNP cord-337849-tyabf12r 145 30 , , , cord-337849-tyabf12r 145 31 and and CC cord-337849-tyabf12r 145 32 the the DT cord-337849-tyabf12r 145 33 co co JJ cord-337849-tyabf12r 145 34 - - JJ cord-337849-tyabf12r 145 35 stimulatory stimulatory JJ cord-337849-tyabf12r 145 36 molecules molecule NNS cord-337849-tyabf12r 145 37 CD40 CD40 NNP cord-337849-tyabf12r 145 38 , , , cord-337849-tyabf12r 145 39 CD80 CD80 NNP cord-337849-tyabf12r 145 40 and and CC cord-337849-tyabf12r 145 41 CD86 CD86 NNP cord-337849-tyabf12r 145 42 [ [ -LRB- cord-337849-tyabf12r 145 43 146 146 CD cord-337849-tyabf12r 145 44 ] ] -RRB- cord-337849-tyabf12r 145 45 [ [ -LRB- cord-337849-tyabf12r 145 46 147 147 CD cord-337849-tyabf12r 145 47 ] ] -RRB- cord-337849-tyabf12r 145 48 [ [ -LRB- cord-337849-tyabf12r 145 49 148 148 CD cord-337849-tyabf12r 145 50 ] ] -RRB- cord-337849-tyabf12r 145 51 , , , cord-337849-tyabf12r 145 52 as as RB cord-337849-tyabf12r 145 53 well well RB cord-337849-tyabf12r 145 54 as as IN cord-337849-tyabf12r 145 55 abrogating abrogate VBG cord-337849-tyabf12r 145 56 the the DT cord-337849-tyabf12r 145 57 chemotactic chemotactic JJ cord-337849-tyabf12r 145 58 response response NN cord-337849-tyabf12r 145 59 to to IN cord-337849-tyabf12r 145 60 CCL4 CCL4 NNP cord-337849-tyabf12r 145 61 and and CC cord-337849-tyabf12r 145 62 CCL19 CCL19 NNP cord-337849-tyabf12r 145 63 [ [ -LRB- cord-337849-tyabf12r 145 64 149 149 CD cord-337849-tyabf12r 145 65 ] ] -RRB- cord-337849-tyabf12r 145 66 . . . cord-337849-tyabf12r 146 1 Already already RB cord-337849-tyabf12r 146 2 differentiated differentiate VBN cord-337849-tyabf12r 146 3 dendritic dendritic JJ cord-337849-tyabf12r 146 4 cells cell NNS cord-337849-tyabf12r 146 5 can can MD cord-337849-tyabf12r 146 6 also also RB cord-337849-tyabf12r 146 7 be be VB cord-337849-tyabf12r 146 8 redirected redirect VBN cord-337849-tyabf12r 146 9 back back RB cord-337849-tyabf12r 146 10 towards towards IN cord-337849-tyabf12r 146 11 a a DT cord-337849-tyabf12r 146 12 monocytic monocytic JJ cord-337849-tyabf12r 146 13 phenotype phenotype NN cord-337849-tyabf12r 146 14 by by IN cord-337849-tyabf12r 146 15 the the DT cord-337849-tyabf12r 146 16 restoration restoration NN cord-337849-tyabf12r 146 17 of of IN cord-337849-tyabf12r 146 18 the the DT cord-337849-tyabf12r 146 19 monocytic monocytic JJ cord-337849-tyabf12r 146 20 marker marker NN cord-337849-tyabf12r 146 21 CD14 CD14 NNP cord-337849-tyabf12r 146 22 [ [ -LRB- cord-337849-tyabf12r 146 23 147 147 CD cord-337849-tyabf12r 146 24 , , , cord-337849-tyabf12r 146 25 150 150 CD cord-337849-tyabf12r 146 26 ] ] -RRB- cord-337849-tyabf12r 146 27 . . . cord-337849-tyabf12r 147 1 The the DT cord-337849-tyabf12r 147 2 antigen antigen NN cord-337849-tyabf12r 147 3 - - HYPH cord-337849-tyabf12r 147 4 presenting present VBG cord-337849-tyabf12r 147 5 and and CC cord-337849-tyabf12r 147 6 T t NN cord-337849-tyabf12r 147 7 - - HYPH cord-337849-tyabf12r 147 8 cell cell NN cord-337849-tyabf12r 147 9 stimulatory stimulatory JJ cord-337849-tyabf12r 147 10 capacity capacity NN cord-337849-tyabf12r 147 11 of of IN cord-337849-tyabf12r 147 12 monocytes monocyte NNS cord-337849-tyabf12r 147 13 and and CC cord-337849-tyabf12r 147 14 macrophages macrophage NNS cord-337849-tyabf12r 147 15 is be VBZ cord-337849-tyabf12r 147 16 also also RB cord-337849-tyabf12r 147 17 impaired impair VBN cord-337849-tyabf12r 147 18 by by IN cord-337849-tyabf12r 147 19 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 147 20 , , , cord-337849-tyabf12r 147 21 with with IN cord-337849-tyabf12r 147 22 a a DT cord-337849-tyabf12r 147 23 decrease decrease NN cord-337849-tyabf12r 147 24 in in IN cord-337849-tyabf12r 147 25 MHC MHC NNP cord-337849-tyabf12r 147 26 class class NN cord-337849-tyabf12r 147 27 II II NNP cord-337849-tyabf12r 147 28 , , , cord-337849-tyabf12r 148 1 CD40 CD40 NNP cord-337849-tyabf12r 148 2 , , , cord-337849-tyabf12r 148 3 CD80 CD80 NNP cord-337849-tyabf12r 148 4 and and CC cord-337849-tyabf12r 148 5 CD86 CD86 NNP cord-337849-tyabf12r 148 6 . . . cord-337849-tyabf12r 148 7 IL-12 il-12 NN cord-337849-tyabf12r 148 8 production production NN cord-337849-tyabf12r 148 9 is be VBZ cord-337849-tyabf12r 148 10 suppressed suppress VBN cord-337849-tyabf12r 148 11 in in IN cord-337849-tyabf12r 148 12 both both DT cord-337849-tyabf12r 148 13 activated activate VBN cord-337849-tyabf12r 148 14 DCs dc NNS cord-337849-tyabf12r 148 15 and and CC cord-337849-tyabf12r 148 16 macrophages macrophage NNS cord-337849-tyabf12r 148 17 , , , cord-337849-tyabf12r 148 18 due due IN cord-337849-tyabf12r 148 19 to to IN cord-337849-tyabf12r 148 20 the the DT cord-337849-tyabf12r 148 21 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 148 22 - - HYPH cord-337849-tyabf12r 148 23 mediated mediate VBN cord-337849-tyabf12r 148 24 down down NN cord-337849-tyabf12r 148 25 - - HYPH cord-337849-tyabf12r 148 26 regulation regulation NN cord-337849-tyabf12r 148 27 of of IN cord-337849-tyabf12r 148 28 NF nf NN cord-337849-tyabf12r 148 29 - - HYPH cord-337849-tyabf12r 148 30 κB κb CD cord-337849-tyabf12r 148 31 activation activation NN cord-337849-tyabf12r 148 32 [ [ -LRB- cord-337849-tyabf12r 148 33 151 151 CD cord-337849-tyabf12r 148 34 ] ] -RRB- cord-337849-tyabf12r 148 35 , , , cord-337849-tyabf12r 148 36 while while IN cord-337849-tyabf12r 148 37 influence influence NN cord-337849-tyabf12r 148 38 on on IN cord-337849-tyabf12r 148 39 the the DT cord-337849-tyabf12r 148 40 expression expression NN cord-337849-tyabf12r 148 41 of of IN cord-337849-tyabf12r 148 42 TNF TNF NNP cord-337849-tyabf12r 148 43 - - HYPH cord-337849-tyabf12r 148 44 α α NNP cord-337849-tyabf12r 148 45 is be VBZ cord-337849-tyabf12r 148 46 dependent dependent JJ cord-337849-tyabf12r 148 47 on on IN cord-337849-tyabf12r 148 48 the the DT cord-337849-tyabf12r 148 49 differentiation differentiation NN cord-337849-tyabf12r 148 50 state state NN cord-337849-tyabf12r 148 51 of of IN cord-337849-tyabf12r 148 52 the the DT cord-337849-tyabf12r 148 53 cells cell NNS cord-337849-tyabf12r 148 54 , , , cord-337849-tyabf12r 148 55 with with IN cord-337849-tyabf12r 148 56 a a DT cord-337849-tyabf12r 148 57 reduction reduction NN cord-337849-tyabf12r 148 58 observed observe VBN cord-337849-tyabf12r 148 59 following follow VBG cord-337849-tyabf12r 148 60 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 148 61 administration administration NN cord-337849-tyabf12r 148 62 in in IN cord-337849-tyabf12r 148 63 LPS LPS NNP cord-337849-tyabf12r 148 64 - - HYPH cord-337849-tyabf12r 148 65 stimulated stimulate VBN cord-337849-tyabf12r 148 66 monocytes monocyte NNS cord-337849-tyabf12r 148 67 and and CC cord-337849-tyabf12r 148 68 PBMCs pbmc NNS cord-337849-tyabf12r 148 69 [ [ -LRB- cord-337849-tyabf12r 148 70 140 140 CD cord-337849-tyabf12r 148 71 , , , cord-337849-tyabf12r 148 72 152 152 CD cord-337849-tyabf12r 148 73 ] ] -RRB- cord-337849-tyabf12r 148 74 . . . cord-337849-tyabf12r 149 1 The the DT cord-337849-tyabf12r 149 2 main main JJ cord-337849-tyabf12r 149 3 function function NN cord-337849-tyabf12r 149 4 of of IN cord-337849-tyabf12r 149 5 DCs DCs NNP cord-337849-tyabf12r 149 6 is be VBZ cord-337849-tyabf12r 149 7 to to TO cord-337849-tyabf12r 149 8 initiate initiate VB cord-337849-tyabf12r 149 9 T t NN cord-337849-tyabf12r 149 10 - - HYPH cord-337849-tyabf12r 149 11 cell cell NN cord-337849-tyabf12r 149 12 responses response NNS cord-337849-tyabf12r 149 13 , , , cord-337849-tyabf12r 149 14 and and CC cord-337849-tyabf12r 149 15 thus thus RB cord-337849-tyabf12r 149 16 the the DT cord-337849-tyabf12r 149 17 effect effect NN cord-337849-tyabf12r 149 18 of of IN cord-337849-tyabf12r 149 19 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 149 20 on on IN cord-337849-tyabf12r 149 21 DCs DCs NNP cord-337849-tyabf12r 149 22 has have VBZ cord-337849-tyabf12r 149 23 a a DT cord-337849-tyabf12r 149 24 major major JJ cord-337849-tyabf12r 149 25 impact impact NN cord-337849-tyabf12r 149 26 on on IN cord-337849-tyabf12r 149 27 T t NN cord-337849-tyabf12r 149 28 - - HYPH cord-337849-tyabf12r 149 29 cells cell NNS cord-337849-tyabf12r 149 30 . . . cord-337849-tyabf12r 150 1 The the DT cord-337849-tyabf12r 150 2 decreased decrease VBN cord-337849-tyabf12r 150 3 surface surface NN cord-337849-tyabf12r 150 4 expression expression NN cord-337849-tyabf12r 150 5 on on IN cord-337849-tyabf12r 150 6 DCs dc NNS cord-337849-tyabf12r 150 7 of of IN cord-337849-tyabf12r 150 8 co co JJ cord-337849-tyabf12r 150 9 - - JJ cord-337849-tyabf12r 150 10 stimulatory stimulatory JJ cord-337849-tyabf12r 150 11 molecules molecule NNS cord-337849-tyabf12r 150 12 and and CC cord-337849-tyabf12r 150 13 MHC MHC NNP cord-337849-tyabf12r 150 14 class class NN cord-337849-tyabf12r 150 15 II II NNP cord-337849-tyabf12r 150 16 results result NNS cord-337849-tyabf12r 150 17 in in IN cord-337849-tyabf12r 150 18 a a DT cord-337849-tyabf12r 150 19 tolerogenic tolerogenic JJ cord-337849-tyabf12r 150 20 phenotype phenotype NN cord-337849-tyabf12r 150 21 , , , cord-337849-tyabf12r 150 22 with with IN cord-337849-tyabf12r 150 23 DC DC NNP cord-337849-tyabf12r 150 24 production production NN cord-337849-tyabf12r 150 25 of of IN cord-337849-tyabf12r 150 26 IL-12 IL-12 NNP cord-337849-tyabf12r 150 27 ( ( -LRB- cord-337849-tyabf12r 150 28 which which WDT cord-337849-tyabf12r 150 29 is be VBZ cord-337849-tyabf12r 150 30 involved involve VBN cord-337849-tyabf12r 150 31 in in IN cord-337849-tyabf12r 150 32 driving drive VBG cord-337849-tyabf12r 150 33 Th1 th1 CD cord-337849-tyabf12r 150 34 differentiation differentiation NN cord-337849-tyabf12r 150 35 ) ) -RRB- cord-337849-tyabf12r 150 36 and and CC cord-337849-tyabf12r 150 37 IL-23 IL-23 NNP cord-337849-tyabf12r 150 38 ( ( -LRB- cord-337849-tyabf12r 150 39 which which WDT cord-337849-tyabf12r 150 40 is be VBZ cord-337849-tyabf12r 150 41 involved involve VBN cord-337849-tyabf12r 150 42 in in IN cord-337849-tyabf12r 150 43 driving drive VBG cord-337849-tyabf12r 150 44 TH17 TH17 NNP cord-337849-tyabf12r 150 45 differentiation differentiation NN cord-337849-tyabf12r 150 46 ) ) -RRB- cord-337849-tyabf12r 150 47 inhibited inhibit VBN cord-337849-tyabf12r 150 48 by by IN cord-337849-tyabf12r 150 49 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 150 50 [ [ -LRB- cord-337849-tyabf12r 150 51 11 11 CD cord-337849-tyabf12r 150 52 , , , cord-337849-tyabf12r 150 53 150 150 CD cord-337849-tyabf12r 150 54 ] ] -RRB- cord-337849-tyabf12r 150 55 . . . cord-337849-tyabf12r 151 1 Even even RB cord-337849-tyabf12r 151 2 when when WRB cord-337849-tyabf12r 151 3 cultured culture VBN cord-337849-tyabf12r 151 4 with with IN cord-337849-tyabf12r 151 5 committed committed JJ cord-337849-tyabf12r 151 6 T t NN cord-337849-tyabf12r 151 7 - - HYPH cord-337849-tyabf12r 151 8 cells cell NNS cord-337849-tyabf12r 151 9 , , , cord-337849-tyabf12r 151 10 these these DT cord-337849-tyabf12r 151 11 tolerogenic tolerogenic NNP cord-337849-tyabf12r 151 12 DCs dc NNS cord-337849-tyabf12r 151 13 caused cause VBD cord-337849-tyabf12r 151 14 hyporesponsiveness hyporesponsiveness NN cord-337849-tyabf12r 151 15 , , , cord-337849-tyabf12r 151 16 decreased decrease VBD cord-337849-tyabf12r 151 17 T t NN cord-337849-tyabf12r 151 18 - - HYPH cord-337849-tyabf12r 151 19 cell cell NN cord-337849-tyabf12r 151 20 proliferation proliferation NN cord-337849-tyabf12r 151 21 and and CC cord-337849-tyabf12r 151 22 reduced reduce VBN cord-337849-tyabf12r 151 23 IFN IFN NNP cord-337849-tyabf12r 151 24 - - HYPH cord-337849-tyabf12r 151 25 γ γ NN cord-337849-tyabf12r 151 26 secretion secretion NN cord-337849-tyabf12r 151 27 [ [ -LRB- cord-337849-tyabf12r 151 28 146 146 CD cord-337849-tyabf12r 151 29 , , , cord-337849-tyabf12r 151 30 153 153 CD cord-337849-tyabf12r 151 31 ] ] -RRB- cord-337849-tyabf12r 151 32 . . . cord-337849-tyabf12r 152 1 IL-12 il-12 UH cord-337849-tyabf12r 152 2 , , , cord-337849-tyabf12r 152 3 as as RB cord-337849-tyabf12r 152 4 well well RB cord-337849-tyabf12r 152 5 as as IN cord-337849-tyabf12r 152 6 stimulating stimulate VBG cord-337849-tyabf12r 152 7 the the DT cord-337849-tyabf12r 152 8 development development NN cord-337849-tyabf12r 152 9 of of IN cord-337849-tyabf12r 152 10 Th1 Th1 NNP cord-337849-tyabf12r 152 11 T T NNP cord-337849-tyabf12r 152 12 - - HYPH cord-337849-tyabf12r 152 13 cells cell NNS cord-337849-tyabf12r 152 14 , , , cord-337849-tyabf12r 152 15 also also RB cord-337849-tyabf12r 152 16 inhibits inhibit VBZ cord-337849-tyabf12r 152 17 the the DT cord-337849-tyabf12r 152 18 development development NN cord-337849-tyabf12r 152 19 of of IN cord-337849-tyabf12r 152 20 Th2 th2 CD cord-337849-tyabf12r 152 21 cells cell NNS cord-337849-tyabf12r 152 22 , , , cord-337849-tyabf12r 152 23 thus thus RB cord-337849-tyabf12r 152 24 resulting result VBG cord-337849-tyabf12r 152 25 in in IN cord-337849-tyabf12r 152 26 vitamin vitamin NN cord-337849-tyabf12r 152 27 D d NN cord-337849-tyabf12r 152 28 shifting shift VBG cord-337849-tyabf12r 152 29 the the DT cord-337849-tyabf12r 152 30 balance balance NN cord-337849-tyabf12r 152 31 of of IN cord-337849-tyabf12r 152 32 T t NN cord-337849-tyabf12r 152 33 - - HYPH cord-337849-tyabf12r 152 34 cells cell NNS cord-337849-tyabf12r 152 35 from from IN cord-337849-tyabf12r 152 36 a a DT cord-337849-tyabf12r 152 37 Th1 th1 NN cord-337849-tyabf12r 152 38 to to IN cord-337849-tyabf12r 152 39 a a DT cord-337849-tyabf12r 152 40 Th2 th2 CD cord-337849-tyabf12r 152 41 phenotype phenotype NN cord-337849-tyabf12r 152 42 [ [ -LRB- cord-337849-tyabf12r 152 43 154 154 CD cord-337849-tyabf12r 152 44 ] ] -RRB- cord-337849-tyabf12r 152 45 . . . cord-337849-tyabf12r 153 1 Concomitantly concomitantly RB cord-337849-tyabf12r 153 2 , , , cord-337849-tyabf12r 153 3 DC DC NNP cord-337849-tyabf12r 153 4 production production NN cord-337849-tyabf12r 153 5 of of IN cord-337849-tyabf12r 153 6 IL-10 IL-10 NNP cord-337849-tyabf12r 153 7 is be VBZ cord-337849-tyabf12r 153 8 increased increase VBN cord-337849-tyabf12r 153 9 . . . cord-337849-tyabf12r 154 1 IL-10 IL-10 NNP cord-337849-tyabf12r 154 2 is be VBZ cord-337849-tyabf12r 154 3 a a DT cord-337849-tyabf12r 154 4 cytokine cytokine NN cord-337849-tyabf12r 154 5 with with IN cord-337849-tyabf12r 154 6 pleiotropic pleiotropic JJ cord-337849-tyabf12r 154 7 effects effect NNS cord-337849-tyabf12r 154 8 in in IN cord-337849-tyabf12r 154 9 immunoregulation immunoregulation NN cord-337849-tyabf12r 154 10 , , , cord-337849-tyabf12r 154 11 and and CC cord-337849-tyabf12r 154 12 levels level NNS cord-337849-tyabf12r 154 13 in in IN cord-337849-tyabf12r 154 14 BAL bal NN cord-337849-tyabf12r 154 15 fluid fluid NN cord-337849-tyabf12r 154 16 have have VBP cord-337849-tyabf12r 154 17 been be VBN cord-337849-tyabf12r 154 18 shown show VBN cord-337849-tyabf12r 154 19 to to TO cord-337849-tyabf12r 154 20 be be VB cord-337849-tyabf12r 154 21 inversely inversely RB cord-337849-tyabf12r 154 22 correlated correlate VBN cord-337849-tyabf12r 154 23 with with IN cord-337849-tyabf12r 154 24 severity severity NN cord-337849-tyabf12r 154 25 / / SYM cord-337849-tyabf12r 154 26 incidence incidence NN cord-337849-tyabf12r 154 27 of of IN cord-337849-tyabf12r 154 28 asthma asthma NN cord-337849-tyabf12r 154 29 [ [ -LRB- cord-337849-tyabf12r 154 30 155 155 CD cord-337849-tyabf12r 154 31 , , , cord-337849-tyabf12r 154 32 156 156 CD cord-337849-tyabf12r 154 33 ] ] -RRB- cord-337849-tyabf12r 154 34 . . . cord-337849-tyabf12r 155 1 This this DT cord-337849-tyabf12r 155 2 IL-10 IL-10 NNP cord-337849-tyabf12r 155 3 production production NN cord-337849-tyabf12r 155 4 drives drive VBZ cord-337849-tyabf12r 155 5 development development NN cord-337849-tyabf12r 155 6 of of IN cord-337849-tyabf12r 155 7 regulatory regulatory JJ cord-337849-tyabf12r 155 8 T T NNP cord-337849-tyabf12r 155 9 - - HYPH cord-337849-tyabf12r 155 10 cells cell NNS cord-337849-tyabf12r 155 11 ( ( -LRB- cord-337849-tyabf12r 155 12 Tregs Tregs NNP cord-337849-tyabf12r 155 13 ) ) -RRB- cord-337849-tyabf12r 155 14 , , , cord-337849-tyabf12r 155 15 and and CC cord-337849-tyabf12r 155 16 these these DT cord-337849-tyabf12r 155 17 Tregs treg NNS cord-337849-tyabf12r 155 18 are be VBP cord-337849-tyabf12r 155 19 able able JJ cord-337849-tyabf12r 155 20 to to TO cord-337849-tyabf12r 155 21 secrete secrete VB cord-337849-tyabf12r 155 22 more more JJR cord-337849-tyabf12r 155 23 IL-10 IL-10 NNP cord-337849-tyabf12r 155 24 as as RB cord-337849-tyabf12r 155 25 well well RB cord-337849-tyabf12r 155 26 as as IN cord-337849-tyabf12r 155 27 the the DT cord-337849-tyabf12r 155 28 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 155 29 cytokine cytokine NN cord-337849-tyabf12r 155 30 TGF TGF NNP cord-337849-tyabf12r 155 31 - - HYPH cord-337849-tyabf12r 155 32 β β NNP cord-337849-tyabf12r 155 33 , , , cord-337849-tyabf12r 155 34 while while IN cord-337849-tyabf12r 155 35 release release NN cord-337849-tyabf12r 155 36 of of IN cord-337849-tyabf12r 155 37 the the DT cord-337849-tyabf12r 155 38 Treg Treg NNP cord-337849-tyabf12r 155 39 cytokine cytokine NN cord-337849-tyabf12r 155 40 CCL22 CCL22 NNP cord-337849-tyabf12r 155 41 is be VBZ cord-337849-tyabf12r 155 42 also also RB cord-337849-tyabf12r 155 43 increased increase VBN cord-337849-tyabf12r 155 44 [ [ -LRB- cord-337849-tyabf12r 155 45 11 11 CD cord-337849-tyabf12r 155 46 ] ] -RRB- cord-337849-tyabf12r 155 47 . . . cord-337849-tyabf12r 156 1 Th17 Th17 NNP cord-337849-tyabf12r 157 1 cells cell NNS cord-337849-tyabf12r 157 2 and and CC cord-337849-tyabf12r 157 3 IL-17 IL-17 NNP cord-337849-tyabf12r 157 4 , , , cord-337849-tyabf12r 157 5 have have VBP cord-337849-tyabf12r 157 6 also also RB cord-337849-tyabf12r 157 7 been be VBN cord-337849-tyabf12r 157 8 shown show VBN cord-337849-tyabf12r 157 9 to to TO cord-337849-tyabf12r 157 10 be be VB cord-337849-tyabf12r 157 11 decreased decrease VBN cord-337849-tyabf12r 157 12 , , , cord-337849-tyabf12r 157 13 with with IN cord-337849-tyabf12r 157 14 calcitriol calcitriol NNP cord-337849-tyabf12r 157 15 ( ( -LRB- cord-337849-tyabf12r 157 16 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 157 17 ) ) -RRB- cord-337849-tyabf12r 157 18 reducing reduce VBG cord-337849-tyabf12r 157 19 IL-17 IL-17 NNP cord-337849-tyabf12r 157 20 production production NN cord-337849-tyabf12r 157 21 in in IN cord-337849-tyabf12r 157 22 a a DT cord-337849-tyabf12r 157 23 mouse mouse NN cord-337849-tyabf12r 157 24 colitis colitis NN cord-337849-tyabf12r 157 25 model model NN cord-337849-tyabf12r 157 26 and and CC cord-337849-tyabf12r 157 27 impairing impair VBG cord-337849-tyabf12r 157 28 commitment commitment NN cord-337849-tyabf12r 157 29 to to IN cord-337849-tyabf12r 157 30 the the DT cord-337849-tyabf12r 157 31 Th17 Th17 NNP cord-337849-tyabf12r 157 32 lineage lineage NN cord-337849-tyabf12r 157 33 in in IN cord-337849-tyabf12r 157 34 mice mouse NNS cord-337849-tyabf12r 157 35 with with IN cord-337849-tyabf12r 157 36 experimental experimental JJ cord-337849-tyabf12r 157 37 autoimmune autoimmune JJ cord-337849-tyabf12r 157 38 uveitis uveitis NN cord-337849-tyabf12r 157 39 [ [ -LRB- cord-337849-tyabf12r 157 40 157 157 CD cord-337849-tyabf12r 157 41 , , , cord-337849-tyabf12r 157 42 158 158 CD cord-337849-tyabf12r 157 43 ] ] -RRB- cord-337849-tyabf12r 157 44 , , , cord-337849-tyabf12r 157 45 although although IN cord-337849-tyabf12r 157 46 these these DT cord-337849-tyabf12r 157 47 effects effect NNS cord-337849-tyabf12r 157 48 may may MD cord-337849-tyabf12r 157 49 not not RB cord-337849-tyabf12r 157 50 translate translate VB cord-337849-tyabf12r 157 51 to to IN cord-337849-tyabf12r 157 52 the the DT cord-337849-tyabf12r 157 53 human human JJ cord-337849-tyabf12r 157 54 respiratory respiratory JJ cord-337849-tyabf12r 157 55 system system NN cord-337849-tyabf12r 157 56 . . . cord-337849-tyabf12r 158 1 Th17 Th17 NNP cord-337849-tyabf12r 159 1 cells cell NNS cord-337849-tyabf12r 159 2 , , , cord-337849-tyabf12r 159 3 by by IN cord-337849-tyabf12r 159 4 releasing release VBG cord-337849-tyabf12r 159 5 IL-17 IL-17 NNP cord-337849-tyabf12r 159 6 , , , cord-337849-tyabf12r 159 7 initiate initiate VB cord-337849-tyabf12r 159 8 an an DT cord-337849-tyabf12r 159 9 inflammatory inflammatory JJ cord-337849-tyabf12r 159 10 response response NN cord-337849-tyabf12r 159 11 dominated dominate VBN cord-337849-tyabf12r 159 12 by by IN cord-337849-tyabf12r 159 13 neutrophils neutrophil NNS cord-337849-tyabf12r 159 14 . . . cord-337849-tyabf12r 160 1 While while IN cord-337849-tyabf12r 160 2 high high JJ cord-337849-tyabf12r 160 3 levels level NNS cord-337849-tyabf12r 160 4 of of IN cord-337849-tyabf12r 160 5 IL-17 IL-17 NNP cord-337849-tyabf12r 160 6 production production NN cord-337849-tyabf12r 160 7 are be VBP cord-337849-tyabf12r 160 8 associated associate VBN cord-337849-tyabf12r 160 9 with with IN cord-337849-tyabf12r 160 10 chronic chronic JJ cord-337849-tyabf12r 160 11 inflammation inflammation NN cord-337849-tyabf12r 160 12 and and CC cord-337849-tyabf12r 160 13 severe severe JJ cord-337849-tyabf12r 160 14 immunopathology immunopathology NN cord-337849-tyabf12r 160 15 [ [ -LRB- cord-337849-tyabf12r 160 16 159 159 CD cord-337849-tyabf12r 160 17 ] ] -RRB- cord-337849-tyabf12r 160 18 , , , cord-337849-tyabf12r 160 19 deficient deficient JJ cord-337849-tyabf12r 160 20 levels level NNS cord-337849-tyabf12r 160 21 , , , cord-337849-tyabf12r 160 22 as as IN cord-337849-tyabf12r 160 23 seen see VBN cord-337849-tyabf12r 160 24 in in IN cord-337849-tyabf12r 160 25 Hyper Hyper NNP cord-337849-tyabf12r 160 26 - - NN cord-337849-tyabf12r 160 27 immunoglobulin immunoglobulin JJ cord-337849-tyabf12r 160 28 E e NN cord-337849-tyabf12r 160 29 syndrome syndrome NN cord-337849-tyabf12r 160 30 ( ( -LRB- cord-337849-tyabf12r 160 31 HIES HIES NNP cord-337849-tyabf12r 160 32 ) ) -RRB- cord-337849-tyabf12r 160 33 , , , cord-337849-tyabf12r 160 34 result result VBP cord-337849-tyabf12r 160 35 in in IN cord-337849-tyabf12r 160 36 recurrent recurrent JJ cord-337849-tyabf12r 160 37 fungal fungal NN cord-337849-tyabf12r 160 38 and and CC cord-337849-tyabf12r 160 39 bacterial bacterial JJ cord-337849-tyabf12r 160 40 infections infection NNS cord-337849-tyabf12r 160 41 [ [ -LRB- cord-337849-tyabf12r 160 42 160 160 CD cord-337849-tyabf12r 160 43 ] ] -RRB- cord-337849-tyabf12r 160 44 . . . cord-337849-tyabf12r 161 1 Therefore therefore RB cord-337849-tyabf12r 161 2 , , , cord-337849-tyabf12r 161 3 vitamin vitamin NN cord-337849-tyabf12r 161 4 D d NN cord-337849-tyabf12r 161 5 may may MD cord-337849-tyabf12r 161 6 have have VB cord-337849-tyabf12r 161 7 a a DT cord-337849-tyabf12r 161 8 beneficial beneficial JJ cord-337849-tyabf12r 161 9 role role NN cord-337849-tyabf12r 161 10 in in IN cord-337849-tyabf12r 161 11 attenuating attenuate VBG cord-337849-tyabf12r 161 12 immunopathology immunopathology NN cord-337849-tyabf12r 161 13 caused cause VBN cord-337849-tyabf12r 161 14 by by IN cord-337849-tyabf12r 161 15 some some DT cord-337849-tyabf12r 161 16 infections infection NNS cord-337849-tyabf12r 161 17 , , , cord-337849-tyabf12r 161 18 but but CC cord-337849-tyabf12r 161 19 be be VB cord-337849-tyabf12r 161 20 detrimental detrimental JJ cord-337849-tyabf12r 161 21 in in IN cord-337849-tyabf12r 161 22 other other JJ cord-337849-tyabf12r 161 23 fungal fungal NN cord-337849-tyabf12r 161 24 and and CC cord-337849-tyabf12r 161 25 bacterial bacterial JJ cord-337849-tyabf12r 161 26 infections infection NNS cord-337849-tyabf12r 161 27 . . . cord-337849-tyabf12r 162 1 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 162 2 has have VBZ cord-337849-tyabf12r 162 3 also also RB cord-337849-tyabf12r 162 4 been be VBN cord-337849-tyabf12r 162 5 demonstrated demonstrate VBN cord-337849-tyabf12r 162 6 to to TO cord-337849-tyabf12r 162 7 have have VB cord-337849-tyabf12r 162 8 direct direct JJ cord-337849-tyabf12r 162 9 effects effect NNS cord-337849-tyabf12r 162 10 on on IN cord-337849-tyabf12r 162 11 T t NN cord-337849-tyabf12r 162 12 - - HYPH cord-337849-tyabf12r 162 13 cells cell NNS cord-337849-tyabf12r 162 14 , , , cord-337849-tyabf12r 162 15 independent independent JJ cord-337849-tyabf12r 162 16 of of IN cord-337849-tyabf12r 162 17 DC DC NNP cord-337849-tyabf12r 162 18 activity activity NN cord-337849-tyabf12r 162 19 . . . cord-337849-tyabf12r 163 1 While while IN cord-337849-tyabf12r 163 2 the the DT cord-337849-tyabf12r 163 3 role role NN cord-337849-tyabf12r 163 4 of of IN cord-337849-tyabf12r 163 5 DCs DCs NNP cord-337849-tyabf12r 163 6 in in IN cord-337849-tyabf12r 163 7 the the DT cord-337849-tyabf12r 163 8 induction induction NN cord-337849-tyabf12r 163 9 of of IN cord-337849-tyabf12r 163 10 Tregs Tregs NNP cord-337849-tyabf12r 163 11 has have VBZ cord-337849-tyabf12r 163 12 been be VBN cord-337849-tyabf12r 163 13 described describe VBN cord-337849-tyabf12r 163 14 , , , cord-337849-tyabf12r 163 15 it -PRON- PRP cord-337849-tyabf12r 163 16 has have VBZ cord-337849-tyabf12r 163 17 also also RB cord-337849-tyabf12r 163 18 been be VBN cord-337849-tyabf12r 163 19 shown show VBN cord-337849-tyabf12r 163 20 that that IN cord-337849-tyabf12r 163 21 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 163 22 in in IN cord-337849-tyabf12r 163 23 combination combination NN cord-337849-tyabf12r 163 24 with with IN cord-337849-tyabf12r 163 25 dexamethasone dexamethasone NN cord-337849-tyabf12r 163 26 can can MD cord-337849-tyabf12r 163 27 induce induce VB cord-337849-tyabf12r 163 28 a a DT cord-337849-tyabf12r 163 29 Treg Treg NNP cord-337849-tyabf12r 163 30 population population NN cord-337849-tyabf12r 163 31 in in IN cord-337849-tyabf12r 163 32 the the DT cord-337849-tyabf12r 163 33 absence absence NN cord-337849-tyabf12r 163 34 of of IN cord-337849-tyabf12r 163 35 APCs apc NNS cord-337849-tyabf12r 163 36 [ [ -LRB- cord-337849-tyabf12r 163 37 161 161 CD cord-337849-tyabf12r 163 38 ] ] -RRB- cord-337849-tyabf12r 163 39 . . . cord-337849-tyabf12r 164 1 The the DT cord-337849-tyabf12r 164 2 proliferation proliferation NN cord-337849-tyabf12r 164 3 and and CC cord-337849-tyabf12r 164 4 cytokine cytokine NN cord-337849-tyabf12r 164 5 profiles profile NNS cord-337849-tyabf12r 164 6 of of IN cord-337849-tyabf12r 164 7 T T NNP cord-337849-tyabf12r 164 8 - - HYPH cord-337849-tyabf12r 164 9 cells cell NNS cord-337849-tyabf12r 164 10 are be VBP cord-337849-tyabf12r 164 11 also also RB cord-337849-tyabf12r 164 12 directly directly RB cord-337849-tyabf12r 164 13 altered alter VBN cord-337849-tyabf12r 164 14 by by IN cord-337849-tyabf12r 164 15 1,25(OH)2D. 1,25(oh)2d. CD cord-337849-tyabf12r 164 16 Production production NN cord-337849-tyabf12r 164 17 of of IN cord-337849-tyabf12r 164 18 IL-2 IL-2 NNP cord-337849-tyabf12r 164 19 , , , cord-337849-tyabf12r 164 20 IFN IFN NNP cord-337849-tyabf12r 164 21 - - HYPH cord-337849-tyabf12r 164 22 γ γ NNP cord-337849-tyabf12r 164 23 , , , cord-337849-tyabf12r 164 24 TNF TNF NNP cord-337849-tyabf12r 164 25 - - HYPH cord-337849-tyabf12r 164 26 α α NNP cord-337849-tyabf12r 164 27 , , , cord-337849-tyabf12r 164 28 IL-17 IL-17 NNP cord-337849-tyabf12r 164 29 and and CC cord-337849-tyabf12r 164 30 IL-21 IL-21 NNP cord-337849-tyabf12r 164 31 are be VBP cord-337849-tyabf12r 164 32 all all RB cord-337849-tyabf12r 164 33 inhibited inhibit VBN cord-337849-tyabf12r 164 34 [ [ -LRB- cord-337849-tyabf12r 164 35 157 157 CD cord-337849-tyabf12r 164 36 , , , cord-337849-tyabf12r 164 37 162 162 CD cord-337849-tyabf12r 164 38 , , , cord-337849-tyabf12r 164 39 163 163 CD cord-337849-tyabf12r 164 40 ] ] -RRB- cord-337849-tyabf12r 164 41 , , , cord-337849-tyabf12r 164 42 with with IN cord-337849-tyabf12r 164 43 inhibition inhibition NN cord-337849-tyabf12r 164 44 of of IN cord-337849-tyabf12r 164 45 IFN IFN NNP cord-337849-tyabf12r 164 46 - - HYPH cord-337849-tyabf12r 164 47 γ γ NNP cord-337849-tyabf12r 164 48 further further RB cord-337849-tyabf12r 164 49 precluding preclude VBG cord-337849-tyabf12r 164 50 macrophage macrophage NN cord-337849-tyabf12r 164 51 activation activation NN cord-337849-tyabf12r 164 52 , , , cord-337849-tyabf12r 164 53 thus thus RB cord-337849-tyabf12r 164 54 attenuating attenuate VBG cord-337849-tyabf12r 164 55 antigen antigen NN cord-337849-tyabf12r 164 56 presentation presentation NN cord-337849-tyabf12r 164 57 and and CC cord-337849-tyabf12r 164 58 the the DT cord-337849-tyabf12r 164 59 recruitment recruitment NN cord-337849-tyabf12r 164 60 of of IN cord-337849-tyabf12r 164 61 other other JJ cord-337849-tyabf12r 164 62 T T NNP cord-337849-tyabf12r 164 63 - - HYPH cord-337849-tyabf12r 164 64 cells cell NNS cord-337849-tyabf12r 164 65 [ [ -LRB- cord-337849-tyabf12r 164 66 164 164 CD cord-337849-tyabf12r 164 67 ] ] -RRB- cord-337849-tyabf12r 164 68 . . . cord-337849-tyabf12r 165 1 This this DT cord-337849-tyabf12r 165 2 direct direct JJ cord-337849-tyabf12r 165 3 inhibition inhibition NN cord-337849-tyabf12r 165 4 of of IN cord-337849-tyabf12r 165 5 Th1-priming Th1-priming NNP cord-337849-tyabf12r 165 6 cytokines cytokine NNS cord-337849-tyabf12r 165 7 further further RB cord-337849-tyabf12r 165 8 skews skew VBZ cord-337849-tyabf12r 165 9 T t NN cord-337849-tyabf12r 165 10 - - HYPH cord-337849-tyabf12r 165 11 cell cell NN cord-337849-tyabf12r 165 12 differentiation differentiation NN cord-337849-tyabf12r 165 13 towards towards IN cord-337849-tyabf12r 165 14 a a DT cord-337849-tyabf12r 165 15 Th2 th2 CD cord-337849-tyabf12r 165 16 phenotype phenotype NN cord-337849-tyabf12r 165 17 . . . cord-337849-tyabf12r 166 1 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 166 2 is be VBZ cord-337849-tyabf12r 166 3 also also RB cord-337849-tyabf12r 166 4 able able JJ cord-337849-tyabf12r 166 5 to to TO cord-337849-tyabf12r 166 6 upregulate upregulate VB cord-337849-tyabf12r 166 7 the the DT cord-337849-tyabf12r 166 8 Th2-specific Th2-specific NNP cord-337849-tyabf12r 166 9 transcription transcription NN cord-337849-tyabf12r 166 10 factors factor NNS cord-337849-tyabf12r 166 11 GATA-3 GATA-3 NNS cord-337849-tyabf12r 166 12 and and CC cord-337849-tyabf12r 166 13 c c NN cord-337849-tyabf12r 166 14 - - HYPH cord-337849-tyabf12r 166 15 maf maf NN cord-337849-tyabf12r 166 16 , , , cord-337849-tyabf12r 166 17 resulting result VBG cord-337849-tyabf12r 166 18 in in IN cord-337849-tyabf12r 166 19 increased increase VBN cord-337849-tyabf12r 166 20 production production NN cord-337849-tyabf12r 166 21 of of IN cord-337849-tyabf12r 166 22 IL-4 IL-4 NNP cord-337849-tyabf12r 166 23 , , , cord-337849-tyabf12r 166 24 IL-5 IL-5 NNP cord-337849-tyabf12r 166 25 and and CC cord-337849-tyabf12r 166 26 IL-10 IL-10 NNP cord-337849-tyabf12r 166 27 [ [ -LRB- cord-337849-tyabf12r 166 28 165 165 CD cord-337849-tyabf12r 166 29 ] ] -RRB- cord-337849-tyabf12r 166 30 . . . cord-337849-tyabf12r 167 1 B b NN cord-337849-tyabf12r 167 2 - - HYPH cord-337849-tyabf12r 167 3 cells cell NNS cord-337849-tyabf12r 167 4 are be VBP cord-337849-tyabf12r 167 5 also also RB cord-337849-tyabf12r 167 6 affected affect VBN cord-337849-tyabf12r 167 7 by by IN cord-337849-tyabf12r 167 8 vitamin vitamin NN cord-337849-tyabf12r 167 9 D d NN cord-337849-tyabf12r 167 10 , , , cord-337849-tyabf12r 167 11 with with IN cord-337849-tyabf12r 167 12 modulation modulation NN cord-337849-tyabf12r 167 13 of of IN cord-337849-tyabf12r 167 14 T t NN cord-337849-tyabf12r 167 15 - - HYPH cord-337849-tyabf12r 167 16 cell cell NN cord-337849-tyabf12r 167 17 responses response NNS cord-337849-tyabf12r 167 18 altering alter VBG cord-337849-tyabf12r 167 19 the the DT cord-337849-tyabf12r 167 20 B b NN cord-337849-tyabf12r 167 21 - - HYPH cord-337849-tyabf12r 167 22 cell cell NN cord-337849-tyabf12r 167 23 compartment compartment NN cord-337849-tyabf12r 167 24 , , , cord-337849-tyabf12r 167 25 as as RB cord-337849-tyabf12r 167 26 well well RB cord-337849-tyabf12r 167 27 as as IN cord-337849-tyabf12r 167 28 having have VBG cord-337849-tyabf12r 167 29 direct direct JJ cord-337849-tyabf12r 167 30 effects effect NNS cord-337849-tyabf12r 167 31 on on IN cord-337849-tyabf12r 167 32 B b NN cord-337849-tyabf12r 167 33 - - HYPH cord-337849-tyabf12r 167 34 cells cell NNS cord-337849-tyabf12r 167 35 themselves -PRON- PRP cord-337849-tyabf12r 167 36 [ [ -LRB- cord-337849-tyabf12r 167 37 11 11 CD cord-337849-tyabf12r 167 38 ] ] -RRB- cord-337849-tyabf12r 167 39 . . . cord-337849-tyabf12r 168 1 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 168 2 is be VBZ cord-337849-tyabf12r 168 3 able able JJ cord-337849-tyabf12r 168 4 to to TO cord-337849-tyabf12r 168 5 inhibit inhibit VB cord-337849-tyabf12r 168 6 proliferation proliferation NN cord-337849-tyabf12r 168 7 , , , cord-337849-tyabf12r 168 8 plasma plasma NN cord-337849-tyabf12r 168 9 - - HYPH cord-337849-tyabf12r 168 10 cell cell NN cord-337849-tyabf12r 168 11 differentiation differentiation NN cord-337849-tyabf12r 168 12 , , , cord-337849-tyabf12r 168 13 immunoglobulin immunoglobulin NN cord-337849-tyabf12r 168 14 secretion secretion NN cord-337849-tyabf12r 168 15 and and CC cord-337849-tyabf12r 168 16 memory memory NN cord-337849-tyabf12r 168 17 B b NN cord-337849-tyabf12r 168 18 - - HYPH cord-337849-tyabf12r 168 19 cell cell NN cord-337849-tyabf12r 168 20 generation generation NN cord-337849-tyabf12r 168 21 , , , cord-337849-tyabf12r 168 22 while while IN cord-337849-tyabf12r 168 23 inducing induce VBG cord-337849-tyabf12r 168 24 B b NN cord-337849-tyabf12r 168 25 - - HYPH cord-337849-tyabf12r 168 26 cell cell NN cord-337849-tyabf12r 168 27 apoptosis apoptosis NN cord-337849-tyabf12r 168 28 [ [ -LRB- cord-337849-tyabf12r 168 29 80 80 CD cord-337849-tyabf12r 168 30 ] ] -RRB- cord-337849-tyabf12r 168 31 . . . cord-337849-tyabf12r 169 1 As as IN cord-337849-tyabf12r 169 2 such such JJ cord-337849-tyabf12r 169 3 , , , cord-337849-tyabf12r 169 4 vitamin vitamin NN cord-337849-tyabf12r 169 5 D d NN cord-337849-tyabf12r 169 6 supplementation supplementation NN cord-337849-tyabf12r 169 7 has have VBZ cord-337849-tyabf12r 169 8 been be VBN cord-337849-tyabf12r 169 9 used use VBN cord-337849-tyabf12r 169 10 in in IN cord-337849-tyabf12r 169 11 the the DT cord-337849-tyabf12r 169 12 treatment treatment NN cord-337849-tyabf12r 169 13 of of IN cord-337849-tyabf12r 169 14 B b NN cord-337849-tyabf12r 169 15 - - HYPH cord-337849-tyabf12r 169 16 cell cell NN cord-337849-tyabf12r 169 17 - - HYPH cord-337849-tyabf12r 169 18 associated associate VBN cord-337849-tyabf12r 169 19 autoimmune autoimmune JJ cord-337849-tyabf12r 169 20 diseases disease NNS cord-337849-tyabf12r 169 21 such such JJ cord-337849-tyabf12r 169 22 as as IN cord-337849-tyabf12r 169 23 systemic systemic JJ cord-337849-tyabf12r 169 24 lupus lupus NN cord-337849-tyabf12r 169 25 erythematous erythematous JJ cord-337849-tyabf12r 169 26 [ [ -LRB- cord-337849-tyabf12r 169 27 166 166 CD cord-337849-tyabf12r 169 28 , , , cord-337849-tyabf12r 169 29 167 167 CD cord-337849-tyabf12r 169 30 ] ] -RRB- cord-337849-tyabf12r 169 31 . . . cord-337849-tyabf12r 170 1 Finally finally RB cord-337849-tyabf12r 170 2 , , , cord-337849-tyabf12r 170 3 it -PRON- PRP cord-337849-tyabf12r 170 4 has have VBZ cord-337849-tyabf12r 170 5 been be VBN cord-337849-tyabf12r 170 6 suggested suggest VBN cord-337849-tyabf12r 170 7 that that IN cord-337849-tyabf12r 170 8 vitamin vitamin NN cord-337849-tyabf12r 170 9 D d NN cord-337849-tyabf12r 170 10 may may MD cord-337849-tyabf12r 170 11 affect affect VB cord-337849-tyabf12r 170 12 other other JJ cord-337849-tyabf12r 170 13 lymphocyte lymphocyte NN cord-337849-tyabf12r 170 14 subsets subset NNS cord-337849-tyabf12r 170 15 , , , cord-337849-tyabf12r 170 16 with with IN cord-337849-tyabf12r 170 17 VDR VDR NNP cord-337849-tyabf12r 170 18 - - HYPH cord-337849-tyabf12r 170 19 KO KO NNP cord-337849-tyabf12r 170 20 mice mouse NNS cord-337849-tyabf12r 170 21 presenting present VBG cord-337849-tyabf12r 170 22 with with IN cord-337849-tyabf12r 170 23 fewer few JJR cord-337849-tyabf12r 170 24 invariant invariant JJ cord-337849-tyabf12r 170 25 natural natural JJ cord-337849-tyabf12r 170 26 killer killer NN cord-337849-tyabf12r 170 27 ( ( -LRB- cord-337849-tyabf12r 170 28 iNKT inkt JJ cord-337849-tyabf12r 170 29 ) ) -RRB- cord-337849-tyabf12r 170 30 cells cell NNS cord-337849-tyabf12r 170 31 [ [ -LRB- cord-337849-tyabf12r 170 32 168 168 CD cord-337849-tyabf12r 170 33 ] ] -RRB- cord-337849-tyabf12r 170 34 , , , cord-337849-tyabf12r 170 35 and and CC cord-337849-tyabf12r 170 36 CD8 CD8 NNP cord-337849-tyabf12r 170 37 + + CC cord-337849-tyabf12r 170 38 T T NNP cord-337849-tyabf12r 170 39 - - HYPH cord-337849-tyabf12r 170 40 cells cell NNS cord-337849-tyabf12r 170 41 from from IN cord-337849-tyabf12r 170 42 MS MS NNP cord-337849-tyabf12r 170 43 patients patient NNS cord-337849-tyabf12r 170 44 secreting secrete VBG cord-337849-tyabf12r 170 45 less less JJR cord-337849-tyabf12r 170 46 IFN IFN NNP cord-337849-tyabf12r 170 47 - - HYPH cord-337849-tyabf12r 170 48 γ γ NNP cord-337849-tyabf12r 170 49 and and CC cord-337849-tyabf12r 170 50 TNF TNF NNP cord-337849-tyabf12r 170 51 - - HYPH cord-337849-tyabf12r 170 52 α α NNP cord-337849-tyabf12r 170 53 and and CC cord-337849-tyabf12r 170 54 more more JJR cord-337849-tyabf12r 170 55 IL-5 IL-5 NNP cord-337849-tyabf12r 170 56 and and CC cord-337849-tyabf12r 170 57 TGF TGF NNP cord-337849-tyabf12r 170 58 - - HYPH cord-337849-tyabf12r 170 59 β β NNP cord-337849-tyabf12r 170 60 following follow VBG cord-337849-tyabf12r 170 61 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 170 62 treatment treatment NN cord-337849-tyabf12r 170 63 [ [ -LRB- cord-337849-tyabf12r 170 64 169 169 CD cord-337849-tyabf12r 170 65 ] ] -RRB- cord-337849-tyabf12r 170 66 . . . cord-337849-tyabf12r 171 1 However however RB cord-337849-tyabf12r 171 2 , , , cord-337849-tyabf12r 171 3 the the DT cord-337849-tyabf12r 171 4 mechanisms mechanism NNS cord-337849-tyabf12r 171 5 behind behind IN cord-337849-tyabf12r 171 6 any any DT cord-337849-tyabf12r 171 7 potential potential JJ cord-337849-tyabf12r 171 8 beneficial beneficial JJ cord-337849-tyabf12r 171 9 role role NN cord-337849-tyabf12r 171 10 of of IN cord-337849-tyabf12r 171 11 vitamin vitamin NN cord-337849-tyabf12r 171 12 D d NN cord-337849-tyabf12r 171 13 are be VBP cord-337849-tyabf12r 171 14 unclear unclear JJ cord-337849-tyabf12r 171 15 , , , cord-337849-tyabf12r 171 16 with with IN cord-337849-tyabf12r 171 17 conflicting conflict VBG cord-337849-tyabf12r 171 18 cellular cellular JJ cord-337849-tyabf12r 171 19 studies study NNS cord-337849-tyabf12r 171 20 on on IN cord-337849-tyabf12r 171 21 the the DT cord-337849-tyabf12r 171 22 effects effect NNS cord-337849-tyabf12r 171 23 of of IN cord-337849-tyabf12r 171 24 vitamin vitamin NN cord-337849-tyabf12r 171 25 D d NN cord-337849-tyabf12r 171 26 on on IN cord-337849-tyabf12r 171 27 Th2 th2 CD cord-337849-tyabf12r 171 28 cells cell NNS cord-337849-tyabf12r 171 29 [ [ -LRB- cord-337849-tyabf12r 171 30 170 170 CD cord-337849-tyabf12r 171 31 , , , cord-337849-tyabf12r 171 32 171 171 CD cord-337849-tyabf12r 171 33 ] ] -RRB- cord-337849-tyabf12r 171 34 , , , cord-337849-tyabf12r 171 35 with with IN cord-337849-tyabf12r 171 36 both both DT cord-337849-tyabf12r 171 37 enhancement enhancement NN cord-337849-tyabf12r 171 38 [ [ -LRB- cord-337849-tyabf12r 171 39 165 165 CD cord-337849-tyabf12r 171 40 ] ] -RRB- cord-337849-tyabf12r 171 41 and and CC cord-337849-tyabf12r 171 42 inhibition inhibition NN cord-337849-tyabf12r 171 43 [ [ -LRB- cord-337849-tyabf12r 171 44 172 172 CD cord-337849-tyabf12r 171 45 ] ] -RRB- cord-337849-tyabf12r 171 46 of of IN cord-337849-tyabf12r 171 47 IL-4 IL-4 NNP cord-337849-tyabf12r 171 48 synthesis synthesis NN cord-337849-tyabf12r 171 49 demonstrated demonstrate VBD cord-337849-tyabf12r 171 50 . . . cord-337849-tyabf12r 172 1 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 172 2 has have VBZ cord-337849-tyabf12r 172 3 also also RB cord-337849-tyabf12r 172 4 been be VBN cord-337849-tyabf12r 172 5 shown show VBN cord-337849-tyabf12r 172 6 to to IN cord-337849-tyabf12r 172 7 down down RB cord-337849-tyabf12r 172 8 - - HYPH cord-337849-tyabf12r 172 9 regulate regulate VB cord-337849-tyabf12r 172 10 DC DC NNP cord-337849-tyabf12r 172 11 - - HYPH cord-337849-tyabf12r 172 12 derived derive VBN cord-337849-tyabf12r 172 13 Ox40L ox40l NN cord-337849-tyabf12r 172 14 , , , cord-337849-tyabf12r 172 15 which which WDT cord-337849-tyabf12r 172 16 is be VBZ cord-337849-tyabf12r 172 17 required require VBN cord-337849-tyabf12r 172 18 for for IN cord-337849-tyabf12r 172 19 Th2 th2 CD cord-337849-tyabf12r 172 20 priming priming NN cord-337849-tyabf12r 172 21 , , , cord-337849-tyabf12r 172 22 thus thus RB cord-337849-tyabf12r 172 23 , , , cord-337849-tyabf12r 172 24 resulting result VBG cord-337849-tyabf12r 172 25 in in IN cord-337849-tyabf12r 172 26 a a DT cord-337849-tyabf12r 172 27 reduced reduced JJ cord-337849-tyabf12r 172 28 Th2 Th2 NNP cord-337849-tyabf12r 172 29 cytokine cytokine NN cord-337849-tyabf12r 172 30 response response NN cord-337849-tyabf12r 172 31 in in IN cord-337849-tyabf12r 172 32 CD4 CD4 NNP cord-337849-tyabf12r 172 33 + + CC cord-337849-tyabf12r 172 34 T T NNP cord-337849-tyabf12r 172 35 - - HYPH cord-337849-tyabf12r 172 36 cells cell NNS cord-337849-tyabf12r 172 37 from from IN cord-337849-tyabf12r 172 38 patients patient NNS cord-337849-tyabf12r 172 39 with with IN cord-337849-tyabf12r 172 40 allergic allergic JJ cord-337849-tyabf12r 172 41 bronchopulmonary bronchopulmonary NNP cord-337849-tyabf12r 172 42 aspergillosis aspergillosis NNP cord-337849-tyabf12r 172 43 [ [ -LRB- cord-337849-tyabf12r 172 44 173 173 CD cord-337849-tyabf12r 172 45 ] ] -RRB- cord-337849-tyabf12r 172 46 , , , cord-337849-tyabf12r 172 47 thus thus RB cord-337849-tyabf12r 172 48 contradicting contradict VBG cord-337849-tyabf12r 172 49 evidence evidence NN cord-337849-tyabf12r 172 50 that that IN cord-337849-tyabf12r 172 51 vitamin vitamin NN cord-337849-tyabf12r 172 52 D d NN cord-337849-tyabf12r 172 53 skews skew VBZ cord-337849-tyabf12r 172 54 the the DT cord-337849-tyabf12r 172 55 T t NN cord-337849-tyabf12r 172 56 - - HYPH cord-337849-tyabf12r 172 57 cell cell NN cord-337849-tyabf12r 172 58 phenotype phenotype NN cord-337849-tyabf12r 172 59 towards towards IN cord-337849-tyabf12r 172 60 a a DT cord-337849-tyabf12r 172 61 Th2 th2 CD cord-337849-tyabf12r 172 62 one one CD cord-337849-tyabf12r 172 63 . . . cord-337849-tyabf12r 173 1 Additionally additionally RB cord-337849-tyabf12r 173 2 , , , cord-337849-tyabf12r 173 3 the the DT cord-337849-tyabf12r 173 4 decrease decrease NN cord-337849-tyabf12r 173 5 in in IN cord-337849-tyabf12r 173 6 Th1 th1 CD cord-337849-tyabf12r 173 7 immunity immunity NN cord-337849-tyabf12r 173 8 which which WDT cord-337849-tyabf12r 173 9 has have VBZ cord-337849-tyabf12r 173 10 been be VBN cord-337849-tyabf12r 173 11 observed observe VBN cord-337849-tyabf12r 173 12 [ [ -LRB- cord-337849-tyabf12r 173 13 11 11 CD cord-337849-tyabf12r 173 14 ] ] -RRB- cord-337849-tyabf12r 173 15 would would MD cord-337849-tyabf12r 173 16 suggest suggest VB cord-337849-tyabf12r 173 17 a a DT cord-337849-tyabf12r 173 18 diminished diminished JJ cord-337849-tyabf12r 173 19 immune immune JJ cord-337849-tyabf12r 173 20 response response NN cord-337849-tyabf12r 173 21 to to IN cord-337849-tyabf12r 173 22 pathogens pathogen NNS cord-337849-tyabf12r 173 23 , , , cord-337849-tyabf12r 173 24 contrasting contrast VBG cord-337849-tyabf12r 173 25 to to IN cord-337849-tyabf12r 173 26 the the DT cord-337849-tyabf12r 173 27 evidence evidence NN cord-337849-tyabf12r 173 28 suggesting suggest VBG cord-337849-tyabf12r 173 29 an an DT cord-337849-tyabf12r 173 30 improved improved JJ cord-337849-tyabf12r 173 31 response response NN cord-337849-tyabf12r 173 32 to to IN cord-337849-tyabf12r 173 33 respiratory respiratory JJ cord-337849-tyabf12r 173 34 tract tract NN cord-337849-tyabf12r 173 35 infections infection NNS cord-337849-tyabf12r 173 36 after after IN cord-337849-tyabf12r 173 37 vitamin vitamin NN cord-337849-tyabf12r 173 38 D d NN cord-337849-tyabf12r 173 39 supplementation supplementation NN cord-337849-tyabf12r 173 40 . . . cord-337849-tyabf12r 174 1 Finally finally RB cord-337849-tyabf12r 174 2 , , , cord-337849-tyabf12r 174 3 while while IN cord-337849-tyabf12r 174 4 studies study NNS cord-337849-tyabf12r 174 5 have have VBP cord-337849-tyabf12r 174 6 demonstrated demonstrate VBN cord-337849-tyabf12r 174 7 direct direct JJ cord-337849-tyabf12r 174 8 effects effect NNS cord-337849-tyabf12r 174 9 of of IN cord-337849-tyabf12r 174 10 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 174 11 administration administration NN cord-337849-tyabf12r 174 12 on on IN cord-337849-tyabf12r 174 13 lymphocytes lymphocyte NNS cord-337849-tyabf12r 174 14 , , , cord-337849-tyabf12r 174 15 others other NNS cord-337849-tyabf12r 174 16 have have VBP cord-337849-tyabf12r 174 17 shown show VBN cord-337849-tyabf12r 174 18 that that IN cord-337849-tyabf12r 174 19 when when WRB cord-337849-tyabf12r 174 20 using use VBG cord-337849-tyabf12r 174 21 the the DT cord-337849-tyabf12r 174 22 inactive inactive JJ cord-337849-tyabf12r 174 23 metabolite metabolite NN cord-337849-tyabf12r 174 24 25(OH)D 25(oh)d CD cord-337849-tyabf12r 174 25 , , , cord-337849-tyabf12r 174 26 DCs dc NNS cord-337849-tyabf12r 174 27 are be VBP cord-337849-tyabf12r 174 28 required require VBN cord-337849-tyabf12r 174 29 to to TO cord-337849-tyabf12r 174 30 convert convert VB cord-337849-tyabf12r 174 31 this this DT cord-337849-tyabf12r 174 32 precursor precursor NN cord-337849-tyabf12r 174 33 to to IN cord-337849-tyabf12r 174 34 the the DT cord-337849-tyabf12r 174 35 active active JJ cord-337849-tyabf12r 174 36 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 174 37 to to TO cord-337849-tyabf12r 174 38 exert exert VB cord-337849-tyabf12r 174 39 its -PRON- PRP$ cord-337849-tyabf12r 174 40 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 174 41 effects effect NNS cord-337849-tyabf12r 174 42 [ [ -LRB- cord-337849-tyabf12r 174 43 174 174 CD cord-337849-tyabf12r 174 44 ] ] -RRB- cord-337849-tyabf12r 174 45 . . . cord-337849-tyabf12r 175 1 This this DT cord-337849-tyabf12r 175 2 indicates indicate VBZ cord-337849-tyabf12r 175 3 that that IN cord-337849-tyabf12r 175 4 administration administration NN cord-337849-tyabf12r 175 5 of of IN cord-337849-tyabf12r 175 6 different different JJ cord-337849-tyabf12r 175 7 vitamin vitamin NN cord-337849-tyabf12r 175 8 D d NN cord-337849-tyabf12r 175 9 metabolites metabolite NNS cord-337849-tyabf12r 175 10 may may MD cord-337849-tyabf12r 175 11 result result VB cord-337849-tyabf12r 175 12 in in IN cord-337849-tyabf12r 175 13 a a DT cord-337849-tyabf12r 175 14 different different JJ cord-337849-tyabf12r 175 15 response response NN cord-337849-tyabf12r 175 16 . . . cord-337849-tyabf12r 176 1 Therefore therefore RB cord-337849-tyabf12r 176 2 , , , cord-337849-tyabf12r 176 3 while while IN cord-337849-tyabf12r 176 4 vitamin vitamin NN cord-337849-tyabf12r 176 5 D d NN cord-337849-tyabf12r 176 6 clearly clearly RB cord-337849-tyabf12r 176 7 acts act VBZ cord-337849-tyabf12r 176 8 as as IN cord-337849-tyabf12r 176 9 an an DT cord-337849-tyabf12r 176 10 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 176 11 molecule molecule NN cord-337849-tyabf12r 176 12 with with IN cord-337849-tyabf12r 176 13 a a DT cord-337849-tyabf12r 176 14 wide wide JJ cord-337849-tyabf12r 176 15 range range NN cord-337849-tyabf12r 176 16 of of IN cord-337849-tyabf12r 176 17 effects effect NNS cord-337849-tyabf12r 176 18 demonstrated demonstrate VBN cord-337849-tyabf12r 176 19 , , , cord-337849-tyabf12r 176 20 the the DT cord-337849-tyabf12r 176 21 precise precise JJ cord-337849-tyabf12r 176 22 mechanisms mechanism NNS cord-337849-tyabf12r 176 23 are be VBP cord-337849-tyabf12r 176 24 currently currently RB cord-337849-tyabf12r 176 25 unclear unclear JJ cord-337849-tyabf12r 176 26 , , , cord-337849-tyabf12r 176 27 with with IN cord-337849-tyabf12r 176 28 the the DT cord-337849-tyabf12r 176 29 conflicting conflict VBG cord-337849-tyabf12r 176 30 results result NNS cord-337849-tyabf12r 176 31 reported report VBN cord-337849-tyabf12r 176 32 also also RB cord-337849-tyabf12r 176 33 adding add VBG cord-337849-tyabf12r 176 34 to to IN cord-337849-tyabf12r 176 35 the the DT cord-337849-tyabf12r 176 36 uncertainty uncertainty NN cord-337849-tyabf12r 176 37 of of IN cord-337849-tyabf12r 176 38 its -PRON- PRP$ cord-337849-tyabf12r 176 39 actions action NNS cord-337849-tyabf12r 176 40 . . . cord-337849-tyabf12r 177 1 The the DT cord-337849-tyabf12r 177 2 main main JJ cord-337849-tyabf12r 177 3 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 177 4 effects effect NNS cord-337849-tyabf12r 177 5 of of IN cord-337849-tyabf12r 177 6 vitamin vitamin NN cord-337849-tyabf12r 177 7 D d NN cord-337849-tyabf12r 177 8 are be VBP cord-337849-tyabf12r 177 9 summarised summarise VBN cord-337849-tyabf12r 177 10 in in IN cord-337849-tyabf12r 177 11 Figure Figure NNP cord-337849-tyabf12r 177 12 3 3 CD cord-337849-tyabf12r 177 13 . . . cord-337849-tyabf12r 178 1 The the DT cord-337849-tyabf12r 178 2 innate innate JJ cord-337849-tyabf12r 178 3 immune immune JJ cord-337849-tyabf12r 178 4 response response NN cord-337849-tyabf12r 178 5 is be VBZ cord-337849-tyabf12r 178 6 affected affect VBN cord-337849-tyabf12r 178 7 , , , cord-337849-tyabf12r 178 8 with with IN cord-337849-tyabf12r 178 9 monocytes monocyte NNS cord-337849-tyabf12r 178 10 producing produce VBG cord-337849-tyabf12r 178 11 more more JJR cord-337849-tyabf12r 178 12 LL-37 LL-37 NNP cord-337849-tyabf12r 178 13 and and CC cord-337849-tyabf12r 178 14 β β NN cord-337849-tyabf12r 178 15 - - HYPH cord-337849-tyabf12r 178 16 defensin defensin NNP cord-337849-tyabf12r 178 17 , , , cord-337849-tyabf12r 178 18 with with IN cord-337849-tyabf12r 178 19 increased increase VBN cord-337849-tyabf12r 178 20 NOD2 NOD2 NNP cord-337849-tyabf12r 178 21 expression expression NN cord-337849-tyabf12r 178 22 and and CC cord-337849-tyabf12r 178 23 autophagy autophagy NN cord-337849-tyabf12r 178 24 , , , cord-337849-tyabf12r 178 25 while while IN cord-337849-tyabf12r 178 26 also also RB cord-337849-tyabf12r 178 27 producing produce VBG cord-337849-tyabf12r 178 28 diminished diminished JJ cord-337849-tyabf12r 178 29 amounts amount NNS cord-337849-tyabf12r 178 30 of of IN cord-337849-tyabf12r 178 31 inflammatory inflammatory JJ cord-337849-tyabf12r 178 32 cytokines cytokine NNS cord-337849-tyabf12r 178 33 , , , cord-337849-tyabf12r 178 34 with with IN cord-337849-tyabf12r 178 35 decreased decrease VBN cord-337849-tyabf12r 178 36 expression expression NN cord-337849-tyabf12r 178 37 of of IN cord-337849-tyabf12r 178 38 TLR2 TLR2 NNP cord-337849-tyabf12r 178 39 and and CC cord-337849-tyabf12r 178 40 TLR4 TLR4 NNP cord-337849-tyabf12r 178 41 . . . cord-337849-tyabf12r 179 1 Differentiation differentiation NN cord-337849-tyabf12r 179 2 into into IN cord-337849-tyabf12r 179 3 macrophages macrophage NNS cord-337849-tyabf12r 179 4 is be VBZ cord-337849-tyabf12r 179 5 increased increase VBN cord-337849-tyabf12r 179 6 , , , cord-337849-tyabf12r 179 7 with with IN cord-337849-tyabf12r 179 8 macrophages macrophage NNS cord-337849-tyabf12r 179 9 having have VBG cord-337849-tyabf12r 179 10 an an DT cord-337849-tyabf12r 179 11 increased increase VBN cord-337849-tyabf12r 179 12 capacity capacity NN cord-337849-tyabf12r 179 13 for for IN cord-337849-tyabf12r 179 14 phagocytosis phagocytosis NN cord-337849-tyabf12r 179 15 and and CC cord-337849-tyabf12r 179 16 chemotaxis chemotaxis NN cord-337849-tyabf12r 179 17 . . . cord-337849-tyabf12r 180 1 However however RB cord-337849-tyabf12r 180 2 , , , cord-337849-tyabf12r 180 3 their -PRON- PRP$ cord-337849-tyabf12r 180 4 APC APC NNP cord-337849-tyabf12r 180 5 and and CC cord-337849-tyabf12r 180 6 T t NN cord-337849-tyabf12r 180 7 - - HYPH cord-337849-tyabf12r 180 8 cell cell NN cord-337849-tyabf12r 180 9 stimulatory stimulatory JJ cord-337849-tyabf12r 180 10 capacity capacity NN cord-337849-tyabf12r 180 11 is be VBZ cord-337849-tyabf12r 180 12 decreased decrease VBN cord-337849-tyabf12r 180 13 . . . cord-337849-tyabf12r 181 1 Monocyte Monocyte NNP cord-337849-tyabf12r 181 2 and and CC cord-337849-tyabf12r 181 3 macrophage macrophage NN cord-337849-tyabf12r 181 4 production production NN cord-337849-tyabf12r 181 5 of of IN cord-337849-tyabf12r 181 6 ROS ROS NNP cord-337849-tyabf12r 181 7 and and CC cord-337849-tyabf12r 181 8 iNOS inos NN cord-337849-tyabf12r 181 9 is be VBZ cord-337849-tyabf12r 181 10 able able JJ cord-337849-tyabf12r 181 11 to to TO cord-337849-tyabf12r 181 12 both both DT cord-337849-tyabf12r 181 13 be be VB cord-337849-tyabf12r 181 14 induced induce VBN cord-337849-tyabf12r 181 15 and and CC cord-337849-tyabf12r 181 16 inhibited inhibit VBN cord-337849-tyabf12r 181 17 , , , cord-337849-tyabf12r 181 18 thus thus RB cord-337849-tyabf12r 181 19 regulating regulate VBG cord-337849-tyabf12r 181 20 their -PRON- PRP$ cord-337849-tyabf12r 181 21 balance balance NN cord-337849-tyabf12r 181 22 . . . cord-337849-tyabf12r 182 1 Differentiation differentiation NN cord-337849-tyabf12r 182 2 into into IN cord-337849-tyabf12r 182 3 DCs dc NNS cord-337849-tyabf12r 182 4 is be VBZ cord-337849-tyabf12r 182 5 inhibited inhibit VBN cord-337849-tyabf12r 182 6 , , , cord-337849-tyabf12r 182 7 with with IN cord-337849-tyabf12r 182 8 DCs dc NNS cord-337849-tyabf12r 182 9 expressing express VBG cord-337849-tyabf12r 182 10 decreased decrease VBN cord-337849-tyabf12r 182 11 levels level NNS cord-337849-tyabf12r 182 12 of of IN cord-337849-tyabf12r 182 13 maturation maturation NN cord-337849-tyabf12r 182 14 surface surface NN cord-337849-tyabf12r 182 15 markers marker NNS cord-337849-tyabf12r 182 16 . . . cord-337849-tyabf12r 183 1 DC DC NNP cord-337849-tyabf12r 183 2 production production NN cord-337849-tyabf12r 183 3 of of IN cord-337849-tyabf12r 183 4 IL-12 IL-12 NNP cord-337849-tyabf12r 183 5 and and CC cord-337849-tyabf12r 183 6 IL-23 IL-23 NNP cord-337849-tyabf12r 183 7 is be VBZ cord-337849-tyabf12r 183 8 decreased decrease VBN cord-337849-tyabf12r 183 9 , , , cord-337849-tyabf12r 183 10 while while IN cord-337849-tyabf12r 183 11 mannose mannose JJ cord-337849-tyabf12r 183 12 receptor receptor NN cord-337849-tyabf12r 183 13 expression expression NN cord-337849-tyabf12r 183 14 and and CC cord-337849-tyabf12r 183 15 production production NN cord-337849-tyabf12r 183 16 of of IN cord-337849-tyabf12r 183 17 IL-10 IL-10 NNP cord-337849-tyabf12r 183 18 and and CC cord-337849-tyabf12r 183 19 CCL22 CCL22 NNPS cord-337849-tyabf12r 183 20 are be VBP cord-337849-tyabf12r 183 21 increased increase VBN cord-337849-tyabf12r 183 22 . . . cord-337849-tyabf12r 184 1 When when WRB cord-337849-tyabf12r 184 2 these these DT cord-337849-tyabf12r 184 3 tolerogenic tolerogenic NNP cord-337849-tyabf12r 184 4 DCs dc NNS cord-337849-tyabf12r 184 5 interact interact VBP cord-337849-tyabf12r 184 6 with with IN cord-337849-tyabf12r 184 7 T T NNP cord-337849-tyabf12r 184 8 - - HYPH cord-337849-tyabf12r 184 9 cells cell NNS cord-337849-tyabf12r 184 10 , , , cord-337849-tyabf12r 184 11 development development NN cord-337849-tyabf12r 184 12 of of IN cord-337849-tyabf12r 184 13 Tregs Tregs NNP cord-337849-tyabf12r 184 14 and and CC cord-337849-tyabf12r 184 15 Th2 th2 CD cord-337849-tyabf12r 184 16 cells cell NNS cord-337849-tyabf12r 184 17 is be VBZ cord-337849-tyabf12r 184 18 increased increase VBN cord-337849-tyabf12r 184 19 , , , cord-337849-tyabf12r 184 20 with with IN cord-337849-tyabf12r 184 21 increased increase VBN cord-337849-tyabf12r 184 22 production production NN cord-337849-tyabf12r 184 23 of of IN cord-337849-tyabf12r 184 24 IL-10 IL-10 NNP cord-337849-tyabf12r 184 25 , , , cord-337849-tyabf12r 184 26 TGF TGF NNP cord-337849-tyabf12r 184 27 - - HYPH cord-337849-tyabf12r 184 28 β β NNP cord-337849-tyabf12r 184 29 , , , cord-337849-tyabf12r 184 30 IL-4 IL-4 NNP cord-337849-tyabf12r 184 31 and and CC cord-337849-tyabf12r 184 32 IL-5 IL-5 NNP cord-337849-tyabf12r 184 33 . . . cord-337849-tyabf12r 185 1 The the DT cord-337849-tyabf12r 185 2 development development NN cord-337849-tyabf12r 185 3 of of IN cord-337849-tyabf12r 185 4 Th1 th1 NN cord-337849-tyabf12r 185 5 and and CC cord-337849-tyabf12r 185 6 Th17 Th17 NNP cord-337849-tyabf12r 185 7 cells cell NNS cord-337849-tyabf12r 185 8 is be VBZ cord-337849-tyabf12r 185 9 inhibited inhibit VBN cord-337849-tyabf12r 185 10 , , , cord-337849-tyabf12r 185 11 with with IN cord-337849-tyabf12r 185 12 decreased decrease VBN cord-337849-tyabf12r 185 13 production production NN cord-337849-tyabf12r 185 14 of of IN cord-337849-tyabf12r 185 15 IL-2 IL-2 NNP cord-337849-tyabf12r 185 16 , , , cord-337849-tyabf12r 185 17 IFN IFN NNP cord-337849-tyabf12r 185 18 - - HYPH cord-337849-tyabf12r 185 19 γ γ NNP cord-337849-tyabf12r 185 20 and and CC cord-337849-tyabf12r 185 21 TNF TNF NNP cord-337849-tyabf12r 185 22 - - HYPH cord-337849-tyabf12r 185 23 α α NNP cord-337849-tyabf12r 185 24 , , , cord-337849-tyabf12r 185 25 and and CC cord-337849-tyabf12r 185 26 attenuation attenuation NN cord-337849-tyabf12r 185 27 of of IN cord-337849-tyabf12r 185 28 macrophage macrophage NN cord-337849-tyabf12r 185 29 activation activation NN cord-337849-tyabf12r 185 30 . . . cord-337849-tyabf12r 186 1 B b NN cord-337849-tyabf12r 186 2 - - HYPH cord-337849-tyabf12r 186 3 cells cell NNS cord-337849-tyabf12r 186 4 are be VBP cord-337849-tyabf12r 186 5 also also RB cord-337849-tyabf12r 186 6 affected affect VBN cord-337849-tyabf12r 186 7 by by IN cord-337849-tyabf12r 186 8 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 186 9 , , , cord-337849-tyabf12r 186 10 demonstrating demonstrate VBG cord-337849-tyabf12r 186 11 decreased decrease VBN cord-337849-tyabf12r 186 12 immunoglobulin immunoglobulin NN cord-337849-tyabf12r 186 13 production production NN cord-337849-tyabf12r 186 14 , , , cord-337849-tyabf12r 186 15 proliferation proliferation NN cord-337849-tyabf12r 186 16 and and CC cord-337849-tyabf12r 186 17 differentiation differentiation NN cord-337849-tyabf12r 186 18 , , , cord-337849-tyabf12r 186 19 but but CC cord-337849-tyabf12r 186 20 increased increase VBN cord-337849-tyabf12r 186 21 apoptosis apoptosis NN cord-337849-tyabf12r 186 22 . . . cord-337849-tyabf12r 187 1 While while IN cord-337849-tyabf12r 187 2 a a DT cord-337849-tyabf12r 187 3 number number NN cord-337849-tyabf12r 187 4 of of IN cord-337849-tyabf12r 187 5 in in FW cord-337849-tyabf12r 187 6 vitro vitro FW cord-337849-tyabf12r 187 7 studies study NNS cord-337849-tyabf12r 187 8 have have VBP cord-337849-tyabf12r 187 9 described describe VBN cord-337849-tyabf12r 187 10 the the DT cord-337849-tyabf12r 187 11 general general JJ cord-337849-tyabf12r 187 12 effects effect NNS cord-337849-tyabf12r 187 13 of of IN cord-337849-tyabf12r 187 14 vitamin vitamin NN cord-337849-tyabf12r 187 15 D d NN cord-337849-tyabf12r 187 16 metabolites metabolite NNS cord-337849-tyabf12r 187 17 on on IN cord-337849-tyabf12r 187 18 the the DT cord-337849-tyabf12r 187 19 function function NN cord-337849-tyabf12r 187 20 of of IN cord-337849-tyabf12r 187 21 immune immune JJ cord-337849-tyabf12r 187 22 cells cell NNS cord-337849-tyabf12r 187 23 and and CC cord-337849-tyabf12r 187 24 secretion secretion NN cord-337849-tyabf12r 187 25 of of IN cord-337849-tyabf12r 187 26 inflammatory inflammatory JJ cord-337849-tyabf12r 187 27 molecules molecule NNS cord-337849-tyabf12r 187 28 , , , cord-337849-tyabf12r 187 29 as as IN cord-337849-tyabf12r 187 30 described describe VBN cord-337849-tyabf12r 187 31 above above RB cord-337849-tyabf12r 187 32 , , , cord-337849-tyabf12r 187 33 experiments experiment NNS cord-337849-tyabf12r 187 34 investigating investigate VBG cord-337849-tyabf12r 187 35 the the DT cord-337849-tyabf12r 187 36 specific specific JJ cord-337849-tyabf12r 187 37 antiviral antiviral JJ cord-337849-tyabf12r 187 38 effects effect NNS cord-337849-tyabf12r 187 39 of of IN cord-337849-tyabf12r 187 40 vitamin vitamin NN cord-337849-tyabf12r 187 41 D d NN cord-337849-tyabf12r 187 42 on on IN cord-337849-tyabf12r 187 43 each each DT cord-337849-tyabf12r 187 44 respiratory respiratory JJ cord-337849-tyabf12r 187 45 virus virus NN cord-337849-tyabf12r 187 46 are be VBP cord-337849-tyabf12r 187 47 limited limited JJ cord-337849-tyabf12r 187 48 . . . cord-337849-tyabf12r 188 1 The the DT cord-337849-tyabf12r 188 2 available available JJ cord-337849-tyabf12r 188 3 literature literature NN cord-337849-tyabf12r 188 4 is be VBZ cord-337849-tyabf12r 188 5 summarised summarise VBN cord-337849-tyabf12r 188 6 below below RB cord-337849-tyabf12r 188 7 , , , cord-337849-tyabf12r 188 8 and and CC cord-337849-tyabf12r 188 9 presented present VBN cord-337849-tyabf12r 188 10 in in IN cord-337849-tyabf12r 188 11 Figure Figure NNP cord-337849-tyabf12r 188 12 4 4 CD cord-337849-tyabf12r 188 13 . . . cord-337849-tyabf12r 189 1 Rhinovirus rhinovirus NN cord-337849-tyabf12r 189 2 infection infection NN cord-337849-tyabf12r 189 3 of of IN cord-337849-tyabf12r 189 4 epithelial epithelial JJ cord-337849-tyabf12r 189 5 cells cell NNS cord-337849-tyabf12r 189 6 results result NNS cord-337849-tyabf12r 189 7 in in IN cord-337849-tyabf12r 189 8 increased increase VBN cord-337849-tyabf12r 189 9 production production NN cord-337849-tyabf12r 189 10 and and CC cord-337849-tyabf12r 189 11 secretion secretion NN cord-337849-tyabf12r 189 12 of of IN cord-337849-tyabf12r 189 13 pro pro JJ cord-337849-tyabf12r 189 14 - - JJ cord-337849-tyabf12r 189 15 inflammatory inflammatory JJ cord-337849-tyabf12r 189 16 cytokines cytokine NNS cord-337849-tyabf12r 189 17 and and CC cord-337849-tyabf12r 189 18 chemokines chemokine NNS cord-337849-tyabf12r 189 19 , , , cord-337849-tyabf12r 189 20 with with IN cord-337849-tyabf12r 189 21 the the DT cord-337849-tyabf12r 189 22 secretion secretion NN cord-337849-tyabf12r 189 23 of of IN cord-337849-tyabf12r 189 24 CXCL8 cxcl8 NN cord-337849-tyabf12r 189 25 and and CC cord-337849-tyabf12r 189 26 CXCL10 CXCL10 NNP cord-337849-tyabf12r 189 27 further further RB cord-337849-tyabf12r 189 28 enhanced enhance VBN cord-337849-tyabf12r 189 29 following follow VBG cord-337849-tyabf12r 189 30 treatment treatment NN cord-337849-tyabf12r 189 31 with with IN cord-337849-tyabf12r 189 32 1,25(OH)2D. 1,25(oh)2d. CD cord-337849-tyabf12r 189 33 During during IN cord-337849-tyabf12r 189 34 RSV RSV NNP cord-337849-tyabf12r 189 35 infection infection NN cord-337849-tyabf12r 189 36 , , , cord-337849-tyabf12r 189 37 IκBα IκBα NNP cord-337849-tyabf12r 189 38 expression expression NN cord-337849-tyabf12r 189 39 is be VBZ cord-337849-tyabf12r 189 40 reduced reduce VBN cord-337849-tyabf12r 189 41 , , , cord-337849-tyabf12r 189 42 resulting result VBG cord-337849-tyabf12r 189 43 in in IN cord-337849-tyabf12r 189 44 increased increase VBN cord-337849-tyabf12r 189 45 transcription transcription NN cord-337849-tyabf12r 189 46 of of IN cord-337849-tyabf12r 189 47 NF nf NN cord-337849-tyabf12r 189 48 - - HYPH cord-337849-tyabf12r 189 49 κB κB NNP cord-337849-tyabf12r 189 50 - - HYPH cord-337849-tyabf12r 189 51 driven drive VBN cord-337849-tyabf12r 189 52 genes gene NNS cord-337849-tyabf12r 189 53 . . . cord-337849-tyabf12r 190 1 STAT1 STAT1 NNP cord-337849-tyabf12r 190 2 is be VBZ cord-337849-tyabf12r 190 3 also also RB cord-337849-tyabf12r 190 4 phosphorylated phosphorylated JJ cord-337849-tyabf12r 190 5 and and CC cord-337849-tyabf12r 190 6 able able JJ cord-337849-tyabf12r 190 7 to to TO cord-337849-tyabf12r 190 8 translocate translocate VB cord-337849-tyabf12r 190 9 into into IN cord-337849-tyabf12r 190 10 the the DT cord-337849-tyabf12r 190 11 nucleus nucleus NN cord-337849-tyabf12r 190 12 resulting result VBG cord-337849-tyabf12r 190 13 in in IN cord-337849-tyabf12r 190 14 increased increase VBN cord-337849-tyabf12r 190 15 expression expression NN cord-337849-tyabf12r 190 16 of of IN cord-337849-tyabf12r 190 17 IRF1 IRF1 NNP cord-337849-tyabf12r 190 18 and and CC cord-337849-tyabf12r 190 19 IRF7 IRF7 NNP cord-337849-tyabf12r 190 20 . . . cord-337849-tyabf12r 191 1 Pre pre JJ cord-337849-tyabf12r 191 2 - - NN cord-337849-tyabf12r 191 3 treatment treatment NN cord-337849-tyabf12r 191 4 with with IN cord-337849-tyabf12r 191 5 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 191 6 increases increase NNS cord-337849-tyabf12r 191 7 IκBα IκBα NNP cord-337849-tyabf12r 191 8 expression expression NN cord-337849-tyabf12r 191 9 and and CC cord-337849-tyabf12r 191 10 decreases decrease VBZ cord-337849-tyabf12r 191 11 STAT1 stat1 NN cord-337849-tyabf12r 191 12 phosphorylation phosphorylation NN cord-337849-tyabf12r 191 13 , , , cord-337849-tyabf12r 191 14 resulting result VBG cord-337849-tyabf12r 191 15 in in IN cord-337849-tyabf12r 191 16 decreased decreased JJ cord-337849-tyabf12r 191 17 production production NN cord-337849-tyabf12r 191 18 of of IN cord-337849-tyabf12r 191 19 CXCL10 CXCL10 NNP cord-337849-tyabf12r 191 20 , , , cord-337849-tyabf12r 191 21 IFN IFN NNP cord-337849-tyabf12r 191 22 - - HYPH cord-337849-tyabf12r 191 23 β β NNP cord-337849-tyabf12r 191 24 , , , cord-337849-tyabf12r 191 25 MxA MxA NNP cord-337849-tyabf12r 191 26 , , , cord-337849-tyabf12r 191 27 ISG15 ISG15 NNP cord-337849-tyabf12r 191 28 , , , cord-337849-tyabf12r 191 29 IRF1 IRF1 NNP cord-337849-tyabf12r 191 30 and and CC cord-337849-tyabf12r 191 31 IRF7 IRF7 NNP cord-337849-tyabf12r 191 32 . . . cord-337849-tyabf12r 192 1 Similarly similarly RB cord-337849-tyabf12r 192 2 , , , cord-337849-tyabf12r 192 3 influenza influenza VB cord-337849-tyabf12r 192 4 A a DT cord-337849-tyabf12r 192 5 infection infection NN cord-337849-tyabf12r 192 6 causes cause VBZ cord-337849-tyabf12r 192 7 increased increase VBN cord-337849-tyabf12r 192 8 expression expression NN cord-337849-tyabf12r 192 9 of of IN cord-337849-tyabf12r 192 10 pro pro JJ cord-337849-tyabf12r 192 11 - - JJ cord-337849-tyabf12r 192 12 inflammatory inflammatory JJ cord-337849-tyabf12r 192 13 cytokines cytokine NNS cord-337849-tyabf12r 192 14 and and CC cord-337849-tyabf12r 192 15 chemokines chemokine NNS cord-337849-tyabf12r 192 16 , , , cord-337849-tyabf12r 192 17 with with IN cord-337849-tyabf12r 192 18 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 192 19 treatment treatment NN cord-337849-tyabf12r 192 20 causing cause VBG cord-337849-tyabf12r 192 21 decreased decrease VBD cord-337849-tyabf12r 192 22 expression expression NN cord-337849-tyabf12r 192 23 of of IN cord-337849-tyabf12r 192 24 TNF TNF NNP cord-337849-tyabf12r 192 25 - - HYPH cord-337849-tyabf12r 192 26 α α NNP cord-337849-tyabf12r 192 27 , , , cord-337849-tyabf12r 192 28 IFN IFN NNP cord-337849-tyabf12r 192 29 - - HYPH cord-337849-tyabf12r 192 30 β β NNP cord-337849-tyabf12r 192 31 , , , cord-337849-tyabf12r 192 32 ISG15 ISG15 NNP cord-337849-tyabf12r 192 33 , , , cord-337849-tyabf12r 192 34 CXCL8 CXCL8 NNP cord-337849-tyabf12r 192 35 , , , cord-337849-tyabf12r 192 36 IL-6 IL-6 NNP cord-337849-tyabf12r 192 37 and and CC cord-337849-tyabf12r 192 38 CCL5 CCL5 NNP cord-337849-tyabf12r 192 39 . . . cord-337849-tyabf12r 193 1 Finally finally RB cord-337849-tyabf12r 193 2 , , , cord-337849-tyabf12r 193 3 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 193 4 is be VBZ cord-337849-tyabf12r 193 5 also also RB cord-337849-tyabf12r 193 6 able able JJ cord-337849-tyabf12r 193 7 to to TO cord-337849-tyabf12r 193 8 increase increase VB cord-337849-tyabf12r 193 9 LL-37 LL-37 NNP cord-337849-tyabf12r 193 10 and and CC cord-337849-tyabf12r 193 11 HBD2 HBD2 NNP cord-337849-tyabf12r 193 12 production production NN cord-337849-tyabf12r 193 13 , , , cord-337849-tyabf12r 193 14 which which WDT cord-337849-tyabf12r 193 15 have have VBP cord-337849-tyabf12r 193 16 been be VBN cord-337849-tyabf12r 193 17 shown show VBN cord-337849-tyabf12r 193 18 to to TO cord-337849-tyabf12r 193 19 have have VB cord-337849-tyabf12r 193 20 antiviral antiviral JJ cord-337849-tyabf12r 193 21 effects effect NNS cord-337849-tyabf12r 193 22 against against IN cord-337849-tyabf12r 193 23 both both CC cord-337849-tyabf12r 193 24 RSV RSV NNP cord-337849-tyabf12r 193 25 and and CC cord-337849-tyabf12r 193 26 influenza influenza NN cord-337849-tyabf12r 193 27 . . . cord-337849-tyabf12r 194 1 Rhinovirus rhinovirus NN cord-337849-tyabf12r 194 2 is be VBZ cord-337849-tyabf12r 194 3 the the DT cord-337849-tyabf12r 194 4 most most RBS cord-337849-tyabf12r 194 5 common common JJ cord-337849-tyabf12r 194 6 aetiologic aetiologic JJ cord-337849-tyabf12r 194 7 agent agent NN cord-337849-tyabf12r 194 8 of of IN cord-337849-tyabf12r 194 9 the the DT cord-337849-tyabf12r 194 10 common common JJ cord-337849-tyabf12r 194 11 cold cold NN cord-337849-tyabf12r 194 12 , , , cord-337849-tyabf12r 194 13 which which WDT cord-337849-tyabf12r 194 14 in in IN cord-337849-tyabf12r 194 15 turn turn NN cord-337849-tyabf12r 194 16 is be VBZ cord-337849-tyabf12r 194 17 the the DT cord-337849-tyabf12r 194 18 most most RBS cord-337849-tyabf12r 194 19 frequent frequent JJ cord-337849-tyabf12r 194 20 acute acute JJ cord-337849-tyabf12r 194 21 infection infection NN cord-337849-tyabf12r 194 22 in in IN cord-337849-tyabf12r 194 23 the the DT cord-337849-tyabf12r 194 24 industrialised industrialised JJ cord-337849-tyabf12r 194 25 world world NN cord-337849-tyabf12r 194 26 , , , cord-337849-tyabf12r 194 27 associated associate VBN cord-337849-tyabf12r 194 28 with with IN cord-337849-tyabf12r 194 29 two two CD cord-337849-tyabf12r 194 30 to to TO cord-337849-tyabf12r 194 31 three three CD cord-337849-tyabf12r 194 32 episodes episode NNS cord-337849-tyabf12r 194 33 per per IN cord-337849-tyabf12r 194 34 year year NN cord-337849-tyabf12r 194 35 in in IN cord-337849-tyabf12r 194 36 adults adult NNS cord-337849-tyabf12r 194 37 , , , cord-337849-tyabf12r 194 38 and and CC cord-337849-tyabf12r 194 39 five five CD cord-337849-tyabf12r 194 40 to to TO cord-337849-tyabf12r 194 41 seven seven CD cord-337849-tyabf12r 194 42 per per IN cord-337849-tyabf12r 194 43 year year NN cord-337849-tyabf12r 194 44 in in IN cord-337849-tyabf12r 194 45 children child NNS cord-337849-tyabf12r 194 46 [ [ -LRB- cord-337849-tyabf12r 194 47 175 175 CD cord-337849-tyabf12r 194 48 ] ] -RRB- cord-337849-tyabf12r 194 49 [ [ -LRB- cord-337849-tyabf12r 194 50 176 176 CD cord-337849-tyabf12r 194 51 ] ] -RRB- cord-337849-tyabf12r 194 52 [ [ -LRB- cord-337849-tyabf12r 194 53 177 177 CD cord-337849-tyabf12r 194 54 ] ] -RRB- cord-337849-tyabf12r 194 55 . . . cord-337849-tyabf12r 195 1 However however RB cord-337849-tyabf12r 195 2 , , , cord-337849-tyabf12r 195 3 only only RB cord-337849-tyabf12r 195 4 one one CD cord-337849-tyabf12r 195 5 study study NN cord-337849-tyabf12r 195 6 has have VBZ cord-337849-tyabf12r 195 7 been be VBN cord-337849-tyabf12r 195 8 carried carry VBN cord-337849-tyabf12r 195 9 out out RP cord-337849-tyabf12r 195 10 to to TO cord-337849-tyabf12r 195 11 determine determine VB cord-337849-tyabf12r 195 12 the the DT cord-337849-tyabf12r 195 13 effect effect NN cord-337849-tyabf12r 195 14 of of IN cord-337849-tyabf12r 195 15 vitamin vitamin NN cord-337849-tyabf12r 195 16 D d NN cord-337849-tyabf12r 195 17 on on IN cord-337849-tyabf12r 195 18 rhinovirus rhinovirus NN cord-337849-tyabf12r 195 19 infection infection NN cord-337849-tyabf12r 195 20 [ [ -LRB- cord-337849-tyabf12r 195 21 178 178 CD cord-337849-tyabf12r 195 22 ] ] -RRB- cord-337849-tyabf12r 195 23 . . . cord-337849-tyabf12r 196 1 Experiments experiment NNS cord-337849-tyabf12r 196 2 were be VBD cord-337849-tyabf12r 196 3 carried carry VBN cord-337849-tyabf12r 196 4 out out RP cord-337849-tyabf12r 196 5 in in IN cord-337849-tyabf12r 196 6 which which WDT cord-337849-tyabf12r 196 7 primary primary JJ cord-337849-tyabf12r 196 8 human human JJ cord-337849-tyabf12r 196 9 bronchial bronchial JJ cord-337849-tyabf12r 196 10 epithelial epithelial JJ cord-337849-tyabf12r 196 11 cells cell NNS cord-337849-tyabf12r 196 12 ( ( -LRB- cord-337849-tyabf12r 196 13 hBECs hbecs ADD cord-337849-tyabf12r 196 14 ) ) -RRB- cord-337849-tyabf12r 196 15 were be VBD cord-337849-tyabf12r 196 16 treated treat VBN cord-337849-tyabf12r 196 17 with with IN cord-337849-tyabf12r 196 18 25(OH)D 25(oh)d CD cord-337849-tyabf12r 196 19 or or CC cord-337849-tyabf12r 196 20 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 196 21 and and CC cord-337849-tyabf12r 196 22 subsequently subsequently RB cord-337849-tyabf12r 196 23 infected infect VBN cord-337849-tyabf12r 196 24 with with IN cord-337849-tyabf12r 196 25 RV-16 RV-16 NNP cord-337849-tyabf12r 196 26 . . . cord-337849-tyabf12r 197 1 Incubation incubation NN cord-337849-tyabf12r 197 2 with with IN cord-337849-tyabf12r 197 3 vitamin vitamin NN cord-337849-tyabf12r 197 4 D d NN cord-337849-tyabf12r 197 5 metabolites metabolite NNS cord-337849-tyabf12r 197 6 had have VBD cord-337849-tyabf12r 197 7 no no DT cord-337849-tyabf12r 197 8 effect effect NN cord-337849-tyabf12r 197 9 on on IN cord-337849-tyabf12r 197 10 viral viral JJ cord-337849-tyabf12r 197 11 replication replication NN cord-337849-tyabf12r 197 12 , , , cord-337849-tyabf12r 197 13 and and CC cord-337849-tyabf12r 197 14 , , , cord-337849-tyabf12r 197 15 whilst whilst IN cord-337849-tyabf12r 197 16 RV-16 RV-16 NNP cord-337849-tyabf12r 197 17 infection infection NN cord-337849-tyabf12r 197 18 induced induce VBN cord-337849-tyabf12r 197 19 hBEC hbec IN cord-337849-tyabf12r 197 20 secretion secretion NN cord-337849-tyabf12r 197 21 of of IN cord-337849-tyabf12r 197 22 CCL5 CCL5 NNP cord-337849-tyabf12r 197 23 , , , cord-337849-tyabf12r 197 24 IL-6 IL-6 NNP cord-337849-tyabf12r 197 25 and and CC cord-337849-tyabf12r 197 26 IL-29 IL-29 NNP cord-337849-tyabf12r 197 27 , , , cord-337849-tyabf12r 197 28 incubation incubation NN cord-337849-tyabf12r 197 29 with with IN cord-337849-tyabf12r 197 30 vitamin vitamin NN cord-337849-tyabf12r 197 31 D d NN cord-337849-tyabf12r 197 32 metabolites metabolite NNS cord-337849-tyabf12r 197 33 did do VBD cord-337849-tyabf12r 197 34 not not RB cord-337849-tyabf12r 197 35 alter alter VB cord-337849-tyabf12r 197 36 this this DT cord-337849-tyabf12r 197 37 effect effect NN cord-337849-tyabf12r 197 38 . . . cord-337849-tyabf12r 198 1 Treatment treatment NN cord-337849-tyabf12r 198 2 with with IN cord-337849-tyabf12r 198 3 vitamin vitamin NN cord-337849-tyabf12r 198 4 D d NN cord-337849-tyabf12r 198 5 did do VBD cord-337849-tyabf12r 198 6 , , , cord-337849-tyabf12r 198 7 however however RB cord-337849-tyabf12r 198 8 , , , cord-337849-tyabf12r 198 9 enhance enhance VB cord-337849-tyabf12r 198 10 secretion secretion NN cord-337849-tyabf12r 198 11 of of IN cord-337849-tyabf12r 198 12 CXCL8 cxcl8 NN cord-337849-tyabf12r 198 13 and and CC cord-337849-tyabf12r 198 14 CXCL10 CXCL10 NNP cord-337849-tyabf12r 198 15 , , , cord-337849-tyabf12r 198 16 both both CC cord-337849-tyabf12r 198 17 in in IN cord-337849-tyabf12r 198 18 the the DT cord-337849-tyabf12r 198 19 presence presence NN cord-337849-tyabf12r 198 20 and and CC cord-337849-tyabf12r 198 21 absence absence NN cord-337849-tyabf12r 198 22 of of IN cord-337849-tyabf12r 198 23 rhinovirus rhinovirus NN cord-337849-tyabf12r 198 24 infection infection NN cord-337849-tyabf12r 198 25 . . . cord-337849-tyabf12r 199 1 These these DT cord-337849-tyabf12r 199 2 molecules molecule NNS cord-337849-tyabf12r 199 3 are be VBP cord-337849-tyabf12r 199 4 pro pro JJ cord-337849-tyabf12r 199 5 - - JJ cord-337849-tyabf12r 199 6 inflammatory inflammatory JJ cord-337849-tyabf12r 199 7 chemokines chemokine NNS cord-337849-tyabf12r 199 8 , , , cord-337849-tyabf12r 199 9 responsible responsible JJ cord-337849-tyabf12r 199 10 for for IN cord-337849-tyabf12r 199 11 the the DT cord-337849-tyabf12r 199 12 recruitment recruitment NN cord-337849-tyabf12r 199 13 of of IN cord-337849-tyabf12r 199 14 immune immune JJ cord-337849-tyabf12r 199 15 cells cell NNS cord-337849-tyabf12r 199 16 such such JJ cord-337849-tyabf12r 199 17 as as IN cord-337849-tyabf12r 199 18 neutrophils neutrophil NNS cord-337849-tyabf12r 199 19 , , , cord-337849-tyabf12r 199 20 macrophages macrophage NNS cord-337849-tyabf12r 199 21 and and CC cord-337849-tyabf12r 199 22 T t NN cord-337849-tyabf12r 199 23 - - HYPH cord-337849-tyabf12r 199 24 cells cell NNS cord-337849-tyabf12r 199 25 to to IN cord-337849-tyabf12r 199 26 the the DT cord-337849-tyabf12r 199 27 site site NN cord-337849-tyabf12r 199 28 of of IN cord-337849-tyabf12r 199 29 infection infection NN cord-337849-tyabf12r 199 30 , , , cord-337849-tyabf12r 199 31 and and CC cord-337849-tyabf12r 199 32 could could MD cord-337849-tyabf12r 199 33 thus thus RB cord-337849-tyabf12r 199 34 act act VB cord-337849-tyabf12r 199 35 as as IN cord-337849-tyabf12r 199 36 an an DT cord-337849-tyabf12r 199 37 effector effector NN cord-337849-tyabf12r 199 38 mechanism mechanism NN cord-337849-tyabf12r 199 39 as as IN cord-337849-tyabf12r 199 40 to to IN cord-337849-tyabf12r 199 41 how how WRB cord-337849-tyabf12r 199 42 vitamin vitamin NN cord-337849-tyabf12r 199 43 D d NN cord-337849-tyabf12r 199 44 alters alter VBZ cord-337849-tyabf12r 199 45 the the DT cord-337849-tyabf12r 199 46 antiviral antiviral JJ cord-337849-tyabf12r 199 47 response response NN cord-337849-tyabf12r 199 48 to to IN cord-337849-tyabf12r 199 49 rhinovirus rhinovirus NN cord-337849-tyabf12r 199 50 infection infection NN cord-337849-tyabf12r 199 51 . . . cord-337849-tyabf12r 200 1 RSV RSV NNP cord-337849-tyabf12r 200 2 is be VBZ cord-337849-tyabf12r 200 3 usually usually RB cord-337849-tyabf12r 200 4 associated associate VBN cord-337849-tyabf12r 200 5 with with IN cord-337849-tyabf12r 200 6 illness illness NN cord-337849-tyabf12r 200 7 in in IN cord-337849-tyabf12r 200 8 young young JJ cord-337849-tyabf12r 200 9 children child NNS cord-337849-tyabf12r 200 10 , , , cord-337849-tyabf12r 200 11 with with IN cord-337849-tyabf12r 200 12 most most JJS cord-337849-tyabf12r 200 13 infants infant NNS cord-337849-tyabf12r 200 14 having have VBG cord-337849-tyabf12r 200 15 been be VBN cord-337849-tyabf12r 200 16 infected infect VBN cord-337849-tyabf12r 200 17 by by IN cord-337849-tyabf12r 200 18 the the DT cord-337849-tyabf12r 200 19 age age NN cord-337849-tyabf12r 200 20 of of IN cord-337849-tyabf12r 200 21 three three CD cord-337849-tyabf12r 200 22 , , , cord-337849-tyabf12r 200 23 causing cause VBG cord-337849-tyabf12r 200 24 a a DT cord-337849-tyabf12r 200 25 mild mild JJ cord-337849-tyabf12r 200 26 URI uri NN cord-337849-tyabf12r 200 27 for for IN cord-337849-tyabf12r 200 28 the the DT cord-337849-tyabf12r 200 29 majority majority NN cord-337849-tyabf12r 200 30 , , , cord-337849-tyabf12r 200 31 but but CC cord-337849-tyabf12r 200 32 severe severe JJ cord-337849-tyabf12r 200 33 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 200 34 in in IN cord-337849-tyabf12r 200 35 some some DT cord-337849-tyabf12r 200 36 [ [ -LRB- cord-337849-tyabf12r 200 37 179 179 CD cord-337849-tyabf12r 200 38 , , , cord-337849-tyabf12r 200 39 180 180 CD cord-337849-tyabf12r 200 40 ] ] -RRB- cord-337849-tyabf12r 200 41 . . . cord-337849-tyabf12r 201 1 It -PRON- PRP cord-337849-tyabf12r 201 2 has have VBZ cord-337849-tyabf12r 201 3 also also RB cord-337849-tyabf12r 201 4 been be VBN cord-337849-tyabf12r 201 5 associated associate VBN cord-337849-tyabf12r 201 6 with with IN cord-337849-tyabf12r 201 7 a a DT cord-337849-tyabf12r 201 8 higher high JJR cord-337849-tyabf12r 201 9 risk risk NN cord-337849-tyabf12r 201 10 of of IN cord-337849-tyabf12r 201 11 developing develop VBG cord-337849-tyabf12r 201 12 asthma asthma NN cord-337849-tyabf12r 201 13 in in IN cord-337849-tyabf12r 201 14 later later JJ cord-337849-tyabf12r 201 15 life life NN cord-337849-tyabf12r 201 16 [ [ -LRB- cord-337849-tyabf12r 201 17 181 181 CD cord-337849-tyabf12r 201 18 ] ] -RRB- cord-337849-tyabf12r 201 19 . . . cord-337849-tyabf12r 202 1 Vitamin vitamin NN cord-337849-tyabf12r 202 2 D d NN cord-337849-tyabf12r 202 3 deficiency deficiency NN cord-337849-tyabf12r 202 4 has have VBZ cord-337849-tyabf12r 202 5 been be VBN cord-337849-tyabf12r 202 6 linked link VBN cord-337849-tyabf12r 202 7 to to IN cord-337849-tyabf12r 202 8 RSV RSV NNP cord-337849-tyabf12r 202 9 susceptibility susceptibility NN cord-337849-tyabf12r 202 10 , , , cord-337849-tyabf12r 202 11 with with IN cord-337849-tyabf12r 202 12 low low JJ cord-337849-tyabf12r 202 13 cord cord NN cord-337849-tyabf12r 202 14 blood blood NN cord-337849-tyabf12r 202 15 plasma plasma NN cord-337849-tyabf12r 202 16 concentrations concentration NNS cord-337849-tyabf12r 202 17 of of IN cord-337849-tyabf12r 202 18 25(OH)D 25(oh)d CD cord-337849-tyabf12r 202 19 related relate VBN cord-337849-tyabf12r 202 20 to to IN cord-337849-tyabf12r 202 21 RSV RSV NNP cord-337849-tyabf12r 202 22 incidence incidence NN cord-337849-tyabf12r 202 23 in in IN cord-337849-tyabf12r 202 24 the the DT cord-337849-tyabf12r 202 25 first first JJ cord-337849-tyabf12r 202 26 year year NN cord-337849-tyabf12r 202 27 of of IN cord-337849-tyabf12r 202 28 life life NN cord-337849-tyabf12r 202 29 [ [ -LRB- cord-337849-tyabf12r 202 30 182 182 CD cord-337849-tyabf12r 202 31 ] ] -RRB- cord-337849-tyabf12r 202 32 , , , cord-337849-tyabf12r 202 33 and and CC cord-337849-tyabf12r 202 34 single single JJ cord-337849-tyabf12r 202 35 nucleotide nucleotide JJ cord-337849-tyabf12r 202 36 polymorphisms polymorphism NNS cord-337849-tyabf12r 202 37 ( ( -LRB- cord-337849-tyabf12r 202 38 SNPs SNPs NNP cord-337849-tyabf12r 202 39 ) ) -RRB- cord-337849-tyabf12r 202 40 in in IN cord-337849-tyabf12r 202 41 the the DT cord-337849-tyabf12r 202 42 VDR VDR NNP cord-337849-tyabf12r 202 43 ( ( -LRB- cord-337849-tyabf12r 202 44 rs10735810 rs10735810 NNP cord-337849-tyabf12r 202 45 and and CC cord-337849-tyabf12r 202 46 the the DT cord-337849-tyabf12r 202 47 Fokl Fokl NNP cord-337849-tyabf12r 202 48 SNP SNP NNP cord-337849-tyabf12r 202 49 ) ) -RRB- cord-337849-tyabf12r 202 50 and and CC cord-337849-tyabf12r 202 51 vitamin vitamin NN cord-337849-tyabf12r 202 52 D d NN cord-337849-tyabf12r 202 53 binding bind VBG cord-337849-tyabf12r 202 54 protein protein NN cord-337849-tyabf12r 202 55 ( ( -LRB- cord-337849-tyabf12r 202 56 the the DT cord-337849-tyabf12r 202 57 GC1s GC1s NNP cord-337849-tyabf12r 202 58 variant variant NN cord-337849-tyabf12r 202 59 ) ) -RRB- cord-337849-tyabf12r 202 60 associated associate VBN cord-337849-tyabf12r 202 61 with with IN cord-337849-tyabf12r 202 62 a a DT cord-337849-tyabf12r 202 63 genetic genetic JJ cord-337849-tyabf12r 202 64 predisposition predisposition NN cord-337849-tyabf12r 202 65 to to IN cord-337849-tyabf12r 202 66 RSV RSV NNP cord-337849-tyabf12r 202 67 bronchiolitis bronchiolitis NNP cord-337849-tyabf12r 202 68 [ [ -LRB- cord-337849-tyabf12r 202 69 183 183 CD cord-337849-tyabf12r 202 70 ] ] -RRB- cord-337849-tyabf12r 202 71 [ [ -LRB- cord-337849-tyabf12r 202 72 184 184 CD cord-337849-tyabf12r 202 73 ] ] -RRB- cord-337849-tyabf12r 202 74 [ [ -LRB- cord-337849-tyabf12r 202 75 185 185 CD cord-337849-tyabf12r 202 76 ] ] -RRB- cord-337849-tyabf12r 202 77 [ [ -LRB- cord-337849-tyabf12r 202 78 186 186 CD cord-337849-tyabf12r 202 79 ] ] -RRB- cord-337849-tyabf12r 202 80 . . . cord-337849-tyabf12r 203 1 However however RB cord-337849-tyabf12r 203 2 , , , cord-337849-tyabf12r 203 3 as as IN cord-337849-tyabf12r 203 4 with with IN cord-337849-tyabf12r 203 5 rhinovirus rhinovirus NN cord-337849-tyabf12r 203 6 , , , cord-337849-tyabf12r 203 7 in in IN cord-337849-tyabf12r 203 8 vitro vitro FW cord-337849-tyabf12r 203 9 work work NN cord-337849-tyabf12r 203 10 investigating investigate VBG cord-337849-tyabf12r 203 11 the the DT cord-337849-tyabf12r 203 12 specific specific JJ cord-337849-tyabf12r 203 13 effects effect NNS cord-337849-tyabf12r 203 14 of of IN cord-337849-tyabf12r 203 15 vitamin vitamin NN cord-337849-tyabf12r 203 16 D d NN cord-337849-tyabf12r 203 17 on on IN cord-337849-tyabf12r 203 18 the the DT cord-337849-tyabf12r 203 19 immune immune JJ cord-337849-tyabf12r 203 20 response response NN cord-337849-tyabf12r 203 21 to to IN cord-337849-tyabf12r 203 22 RSV RSV NNP cord-337849-tyabf12r 203 23 is be VBZ cord-337849-tyabf12r 203 24 limited limit VBN cord-337849-tyabf12r 203 25 . . . cord-337849-tyabf12r 204 1 In in IN cord-337849-tyabf12r 204 2 a a DT cord-337849-tyabf12r 204 3 study study NN cord-337849-tyabf12r 204 4 using use VBG cord-337849-tyabf12r 204 5 primary primary JJ cord-337849-tyabf12r 204 6 human human JJ cord-337849-tyabf12r 204 7 tracheobronchial tracheobronchial JJ cord-337849-tyabf12r 204 8 epithelial epithelial NN cord-337849-tyabf12r 204 9 ( ( -LRB- cord-337849-tyabf12r 204 10 hTBE htbe UH cord-337849-tyabf12r 204 11 ) ) -RRB- cord-337849-tyabf12r 204 12 cells cell NNS cord-337849-tyabf12r 204 13 treated treat VBN cord-337849-tyabf12r 204 14 with with IN cord-337849-tyabf12r 204 15 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 204 16 , , , cord-337849-tyabf12r 204 17 expression expression NN cord-337849-tyabf12r 204 18 of of IN cord-337849-tyabf12r 204 19 the the DT cord-337849-tyabf12r 204 20 NF nf NN cord-337849-tyabf12r 204 21 - - HYPH cord-337849-tyabf12r 204 22 κB κb CD cord-337849-tyabf12r 204 23 inhibitor inhibitor NN cord-337849-tyabf12r 204 24 IκBα IκBα NNP cord-337849-tyabf12r 204 25 was be VBD cord-337849-tyabf12r 204 26 upregulated upregulate VBN cord-337849-tyabf12r 204 27 [ [ -LRB- cord-337849-tyabf12r 204 28 187 187 CD cord-337849-tyabf12r 204 29 ] ] -RRB- cord-337849-tyabf12r 204 30 . . . cord-337849-tyabf12r 205 1 Cells cell NNS cord-337849-tyabf12r 205 2 infected infect VBN cord-337849-tyabf12r 205 3 with with IN cord-337849-tyabf12r 205 4 RSV RSV NNP cord-337849-tyabf12r 205 5 for for IN cord-337849-tyabf12r 205 6 24 24 CD cord-337849-tyabf12r 205 7 h h NNP cord-337849-tyabf12r 205 8 had have VBD cord-337849-tyabf12r 205 9 decreased decrease VBN cord-337849-tyabf12r 205 10 protein protein NN cord-337849-tyabf12r 205 11 levels level NNS cord-337849-tyabf12r 205 12 of of IN cord-337849-tyabf12r 205 13 IκBα IκBα NNP cord-337849-tyabf12r 205 14 , , , cord-337849-tyabf12r 205 15 due due IN cord-337849-tyabf12r 205 16 to to IN cord-337849-tyabf12r 205 17 RSV RSV NNP cord-337849-tyabf12r 205 18 - - HYPH cord-337849-tyabf12r 205 19 induced induce VBN cord-337849-tyabf12r 205 20 degradation degradation NN cord-337849-tyabf12r 205 21 , , , cord-337849-tyabf12r 205 22 but but CC cord-337849-tyabf12r 205 23 in in IN cord-337849-tyabf12r 205 24 cells cell NNS cord-337849-tyabf12r 205 25 pre pre VBP cord-337849-tyabf12r 205 26 - - VBN cord-337849-tyabf12r 205 27 treated treat VBN cord-337849-tyabf12r 205 28 with with IN cord-337849-tyabf12r 205 29 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 205 30 prior prior RB cord-337849-tyabf12r 205 31 to to IN cord-337849-tyabf12r 205 32 RSV RSV NNP cord-337849-tyabf12r 205 33 infection infection NN cord-337849-tyabf12r 205 34 IκBα IκBα NNP cord-337849-tyabf12r 205 35 levels level NNS cord-337849-tyabf12r 205 36 were be VBD cord-337849-tyabf12r 205 37 increased increase VBN cord-337849-tyabf12r 205 38 due due IN cord-337849-tyabf12r 205 39 to to IN cord-337849-tyabf12r 205 40 augmented augment VBN cord-337849-tyabf12r 205 41 mRNA mrna NN cord-337849-tyabf12r 205 42 transcription transcription NN cord-337849-tyabf12r 205 43 and and CC cord-337849-tyabf12r 205 44 protein protein NN cord-337849-tyabf12r 205 45 synthesis synthesis NN cord-337849-tyabf12r 205 46 . . . cord-337849-tyabf12r 206 1 An an DT cord-337849-tyabf12r 206 2 increase increase NN cord-337849-tyabf12r 206 3 in in IN cord-337849-tyabf12r 206 4 IκBα IκBα NNP cord-337849-tyabf12r 206 5 results result NNS cord-337849-tyabf12r 206 6 in in IN cord-337849-tyabf12r 206 7 NF nf NN cord-337849-tyabf12r 206 8 - - HYPH cord-337849-tyabf12r 206 9 κB κB NNP cord-337849-tyabf12r 206 10 remaining remain VBG cord-337849-tyabf12r 206 11 inactive inactive JJ cord-337849-tyabf12r 206 12 in in IN cord-337849-tyabf12r 206 13 the the DT cord-337849-tyabf12r 206 14 cytoplasm cytoplasm NN cord-337849-tyabf12r 206 15 , , , cord-337849-tyabf12r 206 16 preventing prevent VBG cord-337849-tyabf12r 206 17 its -PRON- PRP$ cord-337849-tyabf12r 206 18 translocation translocation NN cord-337849-tyabf12r 206 19 into into IN cord-337849-tyabf12r 206 20 the the DT cord-337849-tyabf12r 206 21 nucleus nucleus NN cord-337849-tyabf12r 206 22 and and CC cord-337849-tyabf12r 206 23 subsequent subsequent JJ cord-337849-tyabf12r 206 24 binding binding NN cord-337849-tyabf12r 206 25 to to IN cord-337849-tyabf12r 206 26 DNA dna NN cord-337849-tyabf12r 206 27 promoter promoter NN cord-337849-tyabf12r 206 28 regions region NNS cord-337849-tyabf12r 206 29 . . . cord-337849-tyabf12r 207 1 Thus thus RB cord-337849-tyabf12r 207 2 , , , cord-337849-tyabf12r 207 3 vitamin vitamin NN cord-337849-tyabf12r 207 4 D d NN cord-337849-tyabf12r 207 5 inhibits inhibit VBZ cord-337849-tyabf12r 207 6 RSV RSV NNP cord-337849-tyabf12r 207 7 induction induction NN cord-337849-tyabf12r 207 8 of of IN cord-337849-tyabf12r 207 9 NF nf NN cord-337849-tyabf12r 207 10 - - HYPH cord-337849-tyabf12r 207 11 κB κB NNP cord-337849-tyabf12r 207 12 - - HYPH cord-337849-tyabf12r 207 13 driven drive VBN cord-337849-tyabf12r 207 14 IFN IFN NNP cord-337849-tyabf12r 207 15 - - HYPH cord-337849-tyabf12r 207 16 β β NNP cord-337849-tyabf12r 207 17 and and CC cord-337849-tyabf12r 207 18 CXCL10 CXCL10 NNP cord-337849-tyabf12r 207 19 secretion secretion NN cord-337849-tyabf12r 207 20 , , , cord-337849-tyabf12r 207 21 as as IN cord-337849-tyabf12r 207 22 also also RB cord-337849-tyabf12r 207 23 demonstrated demonstrate VBN cord-337849-tyabf12r 207 24 in in IN cord-337849-tyabf12r 207 25 this this DT cord-337849-tyabf12r 207 26 study study NN cord-337849-tyabf12r 207 27 . . . cord-337849-tyabf12r 208 1 Additionally additionally RB cord-337849-tyabf12r 208 2 , , , cord-337849-tyabf12r 208 3 interferon interferon NN cord-337849-tyabf12r 208 4 stimulated stimulate VBD cord-337849-tyabf12r 208 5 genes gene NNS cord-337849-tyabf12r 208 6 ( ( -LRB- cord-337849-tyabf12r 208 7 ISGs ISGs NNP cord-337849-tyabf12r 208 8 ) ) -RRB- cord-337849-tyabf12r 208 9 without without IN cord-337849-tyabf12r 208 10 functional functional JJ cord-337849-tyabf12r 208 11 NF nf NN cord-337849-tyabf12r 208 12 - - HYPH cord-337849-tyabf12r 208 13 κB κb CD cord-337849-tyabf12r 208 14 sites site NNS cord-337849-tyabf12r 208 15 in in IN cord-337849-tyabf12r 208 16 their -PRON- PRP$ cord-337849-tyabf12r 208 17 promoters promoter NNS cord-337849-tyabf12r 208 18 were be VBD cord-337849-tyabf12r 208 19 also also RB cord-337849-tyabf12r 208 20 measured measure VBN cord-337849-tyabf12r 208 21 , , , cord-337849-tyabf12r 208 22 with with IN cord-337849-tyabf12r 208 23 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 208 24 treatment treatment NN cord-337849-tyabf12r 208 25 resulting result VBG cord-337849-tyabf12r 208 26 in in IN cord-337849-tyabf12r 208 27 decreased decreased JJ cord-337849-tyabf12r 208 28 levels level NNS cord-337849-tyabf12r 208 29 of of IN cord-337849-tyabf12r 208 30 human human JJ cord-337849-tyabf12r 208 31 myxovirus myxovirus NNP cord-337849-tyabf12r 208 32 resistance resistance NN cord-337849-tyabf12r 208 33 protein protein NNP cord-337849-tyabf12r 208 34 1 1 CD cord-337849-tyabf12r 208 35 ( ( -LRB- cord-337849-tyabf12r 208 36 MxA MxA NNP cord-337849-tyabf12r 208 37 ) ) -RRB- cord-337849-tyabf12r 208 38 and and CC cord-337849-tyabf12r 208 39 ISG15 ISG15 NNP cord-337849-tyabf12r 208 40 . . . cord-337849-tyabf12r 209 1 This this DT cord-337849-tyabf12r 209 2 was be VBD cord-337849-tyabf12r 209 3 demonstrated demonstrate VBN cord-337849-tyabf12r 209 4 to to TO cord-337849-tyabf12r 209 5 be be VB cord-337849-tyabf12r 209 6 a a DT cord-337849-tyabf12r 209 7 consequence consequence NN cord-337849-tyabf12r 209 8 of of IN cord-337849-tyabf12r 209 9 the the DT cord-337849-tyabf12r 209 10 suppression suppression NN cord-337849-tyabf12r 209 11 of of IN cord-337849-tyabf12r 209 12 NF NF NNP cord-337849-tyabf12r 209 13 - - HYPH cord-337849-tyabf12r 209 14 κB κB NNP cord-337849-tyabf12r 209 15 - - HYPH cord-337849-tyabf12r 209 16 driven drive VBN cord-337849-tyabf12r 209 17 IFN IFN NNP cord-337849-tyabf12r 209 18 - - HYPH cord-337849-tyabf12r 209 19 β β NN cord-337849-tyabf12r 209 20 production production NN cord-337849-tyabf12r 209 21 . . . cord-337849-tyabf12r 210 1 Similarly similarly RB cord-337849-tyabf12r 210 2 , , , cord-337849-tyabf12r 210 3 pre pre JJ cord-337849-tyabf12r 210 4 - - NN cord-337849-tyabf12r 210 5 treatment treatment NN cord-337849-tyabf12r 210 6 with with IN cord-337849-tyabf12r 210 7 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 210 8 before before IN cord-337849-tyabf12r 210 9 inoculation inoculation NN cord-337849-tyabf12r 210 10 with with IN cord-337849-tyabf12r 210 11 RSV RSV NNP cord-337849-tyabf12r 210 12 resulted result VBD cord-337849-tyabf12r 210 13 in in IN cord-337849-tyabf12r 210 14 decreased decrease VBN cord-337849-tyabf12r 210 15 levels level NNS cord-337849-tyabf12r 210 16 of of IN cord-337849-tyabf12r 210 17 STAT1 stat1 NN cord-337849-tyabf12r 210 18 protein protein NN cord-337849-tyabf12r 210 19 and and CC cord-337849-tyabf12r 210 20 inhibition inhibition NN cord-337849-tyabf12r 210 21 of of IN cord-337849-tyabf12r 210 22 STAT-1 stat-1 NN cord-337849-tyabf12r 210 23 translocation translocation NN cord-337849-tyabf12r 210 24 to to IN cord-337849-tyabf12r 210 25 the the DT cord-337849-tyabf12r 210 26 nucleus nucleus NN cord-337849-tyabf12r 210 27 , , , cord-337849-tyabf12r 210 28 also also RB cord-337849-tyabf12r 210 29 as as IN cord-337849-tyabf12r 210 30 a a DT cord-337849-tyabf12r 210 31 consequence consequence NN cord-337849-tyabf12r 210 32 of of IN cord-337849-tyabf12r 210 33 suppression suppression NN cord-337849-tyabf12r 210 34 of of IN cord-337849-tyabf12r 210 35 NF nf NN cord-337849-tyabf12r 210 36 - - HYPH cord-337849-tyabf12r 210 37 κB κB NNP cord-337849-tyabf12r 210 38 - - HYPH cord-337849-tyabf12r 210 39 driven drive VBN cord-337849-tyabf12r 210 40 IFN IFN NNP cord-337849-tyabf12r 210 41 - - HYPH cord-337849-tyabf12r 210 42 β β NN cord-337849-tyabf12r 210 43 production production NN cord-337849-tyabf12r 210 44 . . . cord-337849-tyabf12r 211 1 However however RB cord-337849-tyabf12r 211 2 , , , cord-337849-tyabf12r 211 3 even even RB cord-337849-tyabf12r 211 4 though though IN cord-337849-tyabf12r 211 5 production production NN cord-337849-tyabf12r 211 6 of of IN cord-337849-tyabf12r 211 7 important important JJ cord-337849-tyabf12r 211 8 components component NNS cord-337849-tyabf12r 211 9 in in IN cord-337849-tyabf12r 211 10 the the DT cord-337849-tyabf12r 211 11 antiviral antiviral JJ cord-337849-tyabf12r 211 12 response response NN cord-337849-tyabf12r 211 13 to to IN cord-337849-tyabf12r 211 14 RSV RSV NNP cord-337849-tyabf12r 211 15 infection infection NN cord-337849-tyabf12r 212 1 ( ( -LRB- cord-337849-tyabf12r 212 2 IFN IFN NNP cord-337849-tyabf12r 212 3 - - HYPH cord-337849-tyabf12r 212 4 β β NNP cord-337849-tyabf12r 212 5 , , , cord-337849-tyabf12r 212 6 CXCL10 CXCL10 NNP cord-337849-tyabf12r 212 7 , , , cord-337849-tyabf12r 212 8 STAT1 stat1 XX cord-337849-tyabf12r 212 9 , , , cord-337849-tyabf12r 212 10 MxA mxa NN cord-337849-tyabf12r 212 11 and and CC cord-337849-tyabf12r 212 12 ISG15 isg15 NN cord-337849-tyabf12r 212 13 ) ) -RRB- cord-337849-tyabf12r 212 14 were be VBD cord-337849-tyabf12r 212 15 reduced reduce VBN cord-337849-tyabf12r 212 16 by by IN cord-337849-tyabf12r 212 17 treatment treatment NN cord-337849-tyabf12r 212 18 with with IN cord-337849-tyabf12r 212 19 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 212 20 , , , cord-337849-tyabf12r 212 21 viral viral JJ cord-337849-tyabf12r 212 22 replication replication NN cord-337849-tyabf12r 212 23 and and CC cord-337849-tyabf12r 212 24 viral viral JJ cord-337849-tyabf12r 212 25 load load NN cord-337849-tyabf12r 212 26 was be VBD cord-337849-tyabf12r 212 27 not not RB cord-337849-tyabf12r 212 28 increased increase VBN cord-337849-tyabf12r 212 29 . . . cord-337849-tyabf12r 213 1 Thus thus RB cord-337849-tyabf12r 213 2 , , , cord-337849-tyabf12r 213 3 via via IN cord-337849-tyabf12r 213 4 increasing increase VBG cord-337849-tyabf12r 213 5 IκBα IκBα NNP cord-337849-tyabf12r 213 6 levels level NNS cord-337849-tyabf12r 213 7 , , , cord-337849-tyabf12r 213 8 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 213 9 is be VBZ cord-337849-tyabf12r 213 10 able able JJ cord-337849-tyabf12r 213 11 to to TO cord-337849-tyabf12r 213 12 dampen dampen VB cord-337849-tyabf12r 213 13 the the DT cord-337849-tyabf12r 213 14 inflammatory inflammatory JJ cord-337849-tyabf12r 213 15 response response NN cord-337849-tyabf12r 213 16 to to IN cord-337849-tyabf12r 213 17 RSV RSV NNP cord-337849-tyabf12r 213 18 infection infection NN cord-337849-tyabf12r 213 19 whilst whilst IN cord-337849-tyabf12r 213 20 maintaining maintain VBG cord-337849-tyabf12r 213 21 the the DT cord-337849-tyabf12r 213 22 antiviral antiviral JJ cord-337849-tyabf12r 213 23 state state NN cord-337849-tyabf12r 213 24 and and CC cord-337849-tyabf12r 213 25 without without IN cord-337849-tyabf12r 213 26 having have VBG cord-337849-tyabf12r 213 27 adverse adverse JJ cord-337849-tyabf12r 213 28 effects effect NNS cord-337849-tyabf12r 213 29 on on IN cord-337849-tyabf12r 213 30 viral viral JJ cord-337849-tyabf12r 213 31 load load NN cord-337849-tyabf12r 213 32 , , , cord-337849-tyabf12r 213 33 suggesting suggest VBG cord-337849-tyabf12r 213 34 a a DT cord-337849-tyabf12r 213 35 potential potential JJ cord-337849-tyabf12r 213 36 role role NN cord-337849-tyabf12r 213 37 in in IN cord-337849-tyabf12r 213 38 reducing reduce VBG cord-337849-tyabf12r 213 39 immunopathology immunopathology NN cord-337849-tyabf12r 213 40 . . . cord-337849-tyabf12r 214 1 A a DT cord-337849-tyabf12r 214 2 similar similar JJ cord-337849-tyabf12r 214 3 study study NN cord-337849-tyabf12r 214 4 using use VBG cord-337849-tyabf12r 214 5 alveolar alveolar NN cord-337849-tyabf12r 214 6 A549 A549 NNP cord-337849-tyabf12r 214 7 cells cell NNS cord-337849-tyabf12r 214 8 infected infect VBN cord-337849-tyabf12r 214 9 with with IN cord-337849-tyabf12r 214 10 RSV RSV NNP cord-337849-tyabf12r 214 11 has have VBZ cord-337849-tyabf12r 214 12 also also RB cord-337849-tyabf12r 214 13 demonstrated demonstrate VBN cord-337849-tyabf12r 214 14 that that IN cord-337849-tyabf12r 214 15 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 214 16 is be VBZ cord-337849-tyabf12r 214 17 able able JJ cord-337849-tyabf12r 214 18 to to TO cord-337849-tyabf12r 214 19 decrease decrease VB cord-337849-tyabf12r 214 20 levels level NNS cord-337849-tyabf12r 214 21 of of IN cord-337849-tyabf12r 214 22 phosphorylated phosphorylated JJ cord-337849-tyabf12r 214 23 STAT-1 STAT-1 NNS cord-337849-tyabf12r 214 24 ( ( -LRB- cord-337849-tyabf12r 214 25 pSTAT-1 pSTAT-1 NNP cord-337849-tyabf12r 214 26 ) ) -RRB- cord-337849-tyabf12r 214 27 and and CC cord-337849-tyabf12r 214 28 increase increase VB cord-337849-tyabf12r 214 29 IκBα IκBα NNP cord-337849-tyabf12r 214 30 protein protein NN cord-337849-tyabf12r 214 31 levels level NNS cord-337849-tyabf12r 214 32 , , , cord-337849-tyabf12r 214 33 with with IN cord-337849-tyabf12r 214 34 subsequent subsequent JJ cord-337849-tyabf12r 214 35 diminished diminished JJ cord-337849-tyabf12r 214 36 expression expression NN cord-337849-tyabf12r 214 37 of of IN cord-337849-tyabf12r 214 38 interferon interferon NN cord-337849-tyabf12r 214 39 regulatory regulatory JJ cord-337849-tyabf12r 214 40 factor factor NN cord-337849-tyabf12r 214 41 1 1 CD cord-337849-tyabf12r 214 42 ( ( -LRB- cord-337849-tyabf12r 214 43 IRF1 IRF1 NNP cord-337849-tyabf12r 214 44 ) ) -RRB- cord-337849-tyabf12r 214 45 , , , cord-337849-tyabf12r 214 46 IRF7 IRF7 NNP cord-337849-tyabf12r 214 47 , , , cord-337849-tyabf12r 214 48 IFN IFN NNP cord-337849-tyabf12r 214 49 - - HYPH cord-337849-tyabf12r 214 50 β β NNP cord-337849-tyabf12r 214 51 and and CC cord-337849-tyabf12r 214 52 CXCL8 CXCL8 NNP cord-337849-tyabf12r 214 53 mRNA mRNA NNP cord-337849-tyabf12r 214 54 [ [ -LRB- cord-337849-tyabf12r 214 55 188 188 CD cord-337849-tyabf12r 214 56 ] ] -RRB- cord-337849-tyabf12r 214 57 . . . cord-337849-tyabf12r 215 1 This this DT cord-337849-tyabf12r 215 2 study study NN cord-337849-tyabf12r 215 3 also also RB cord-337849-tyabf12r 215 4 used use VBD cord-337849-tyabf12r 215 5 retroviral retroviral JJ cord-337849-tyabf12r 215 6 transduction transduction NN cord-337849-tyabf12r 215 7 to to TO cord-337849-tyabf12r 215 8 overexpress overexpress VB cord-337849-tyabf12r 215 9 the the DT cord-337849-tyabf12r 215 10 common common JJ cord-337849-tyabf12r 215 11 M4 M4 NNP cord-337849-tyabf12r 215 12 VDR VDR NNP cord-337849-tyabf12r 215 13 variant variant NN cord-337849-tyabf12r 215 14 , , , cord-337849-tyabf12r 215 15 or or CC cord-337849-tyabf12r 215 16 the the DT cord-337849-tyabf12r 215 17 M1 M1 NNP cord-337849-tyabf12r 215 18 FokI FokI NNP cord-337849-tyabf12r 215 19 VDR VDR NNP cord-337849-tyabf12r 215 20 variant variant NN cord-337849-tyabf12r 215 21 , , , cord-337849-tyabf12r 215 22 which which WDT cord-337849-tyabf12r 215 23 has have VBZ cord-337849-tyabf12r 215 24 been be VBN cord-337849-tyabf12r 215 25 associated associate VBN cord-337849-tyabf12r 215 26 with with IN cord-337849-tyabf12r 215 27 severe severe JJ cord-337849-tyabf12r 215 28 RSV RSV NNP cord-337849-tyabf12r 215 29 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 215 30 . . . cord-337849-tyabf12r 216 1 No no DT cord-337849-tyabf12r 216 2 differences difference NNS cord-337849-tyabf12r 216 3 were be VBD cord-337849-tyabf12r 216 4 observed observe VBN cord-337849-tyabf12r 216 5 between between IN cord-337849-tyabf12r 216 6 the the DT cord-337849-tyabf12r 216 7 two two CD cord-337849-tyabf12r 216 8 variants variant NNS cord-337849-tyabf12r 216 9 in in IN cord-337849-tyabf12r 216 10 viral viral JJ cord-337849-tyabf12r 216 11 replication replication NN cord-337849-tyabf12r 216 12 , , , cord-337849-tyabf12r 216 13 or or CC cord-337849-tyabf12r 216 14 the the DT cord-337849-tyabf12r 216 15 vitamin vitamin NN cord-337849-tyabf12r 216 16 D d NN cord-337849-tyabf12r 216 17 - - HYPH cord-337849-tyabf12r 216 18 induced induce VBN cord-337849-tyabf12r 216 19 increase increase NN cord-337849-tyabf12r 216 20 in in IN cord-337849-tyabf12r 216 21 IκBα IκBα NNP cord-337849-tyabf12r 216 22 and and CC cord-337849-tyabf12r 216 23 repression repression NN cord-337849-tyabf12r 216 24 of of IN cord-337849-tyabf12r 216 25 NF nf NN cord-337849-tyabf12r 216 26 - - HYPH cord-337849-tyabf12r 216 27 κB κB NNP cord-337849-tyabf12r 216 28 - - HYPH cord-337849-tyabf12r 216 29 regulated regulate VBN cord-337849-tyabf12r 216 30 genes gene NNS cord-337849-tyabf12r 216 31 . . . cord-337849-tyabf12r 217 1 However however RB cord-337849-tyabf12r 217 2 , , , cord-337849-tyabf12r 217 3 in in IN cord-337849-tyabf12r 217 4 M1 M1 NNP cord-337849-tyabf12r 217 5 FokI FokI NNP cord-337849-tyabf12r 217 6 VDR VDR NNP cord-337849-tyabf12r 217 7 - - HYPH cord-337849-tyabf12r 217 8 expressing express VBG cord-337849-tyabf12r 217 9 cells cell NNS cord-337849-tyabf12r 217 10 , , , cord-337849-tyabf12r 217 11 vitamin vitamin NN cord-337849-tyabf12r 217 12 D d NN cord-337849-tyabf12r 217 13 was be VBD cord-337849-tyabf12r 217 14 not not RB cord-337849-tyabf12r 217 15 able able JJ cord-337849-tyabf12r 217 16 to to TO cord-337849-tyabf12r 217 17 repress repress VB cord-337849-tyabf12r 217 18 expression expression NN cord-337849-tyabf12r 217 19 of of IN cord-337849-tyabf12r 217 20 the the DT cord-337849-tyabf12r 217 21 STAT-1 STAT-1 NNP cord-337849-tyabf12r 217 22 regulated regulate VBN cord-337849-tyabf12r 217 23 genes gene NNS cord-337849-tyabf12r 217 24 IRF1 IRF1 NNP cord-337849-tyabf12r 217 25 and and CC cord-337849-tyabf12r 217 26 IRF7 IRF7 NNP cord-337849-tyabf12r 217 27 , , , cord-337849-tyabf12r 217 28 due due JJ cord-337849-tyabf12r 217 29 to to IN cord-337849-tyabf12r 217 30 decreased decrease VBN cord-337849-tyabf12r 217 31 regulation regulation NN cord-337849-tyabf12r 217 32 of of IN cord-337849-tyabf12r 217 33 STAT-1 STAT-1 NNS cord-337849-tyabf12r 217 34 phosphorylation phosphorylation NN cord-337849-tyabf12r 217 35 . . . cord-337849-tyabf12r 218 1 Therefore therefore RB cord-337849-tyabf12r 218 2 , , , cord-337849-tyabf12r 218 3 together together RB cord-337849-tyabf12r 218 4 these these DT cord-337849-tyabf12r 218 5 studies study NNS cord-337849-tyabf12r 218 6 indicate indicate VBP cord-337849-tyabf12r 218 7 that that IN cord-337849-tyabf12r 218 8 vitamin vitamin NN cord-337849-tyabf12r 218 9 D d NN cord-337849-tyabf12r 218 10 is be VBZ cord-337849-tyabf12r 218 11 able able JJ cord-337849-tyabf12r 218 12 to to TO cord-337849-tyabf12r 218 13 dampen dampen VB cord-337849-tyabf12r 218 14 NF NF NNP cord-337849-tyabf12r 218 15 - - HYPH cord-337849-tyabf12r 218 16 κB κB NNP cord-337849-tyabf12r 218 17 and and CC cord-337849-tyabf12r 218 18 STAT-1 STAT-1 NNP cord-337849-tyabf12r 218 19 mediated mediate VBD cord-337849-tyabf12r 218 20 inflammation inflammation NN cord-337849-tyabf12r 218 21 to to TO cord-337849-tyabf12r 218 22 reduce reduce VB cord-337849-tyabf12r 218 23 RSV RSV NNP cord-337849-tyabf12r 218 24 immunopathology immunopathology NN cord-337849-tyabf12r 218 25 , , , cord-337849-tyabf12r 218 26 with with IN cord-337849-tyabf12r 218 27 an an DT cord-337849-tyabf12r 218 28 impairment impairment NN cord-337849-tyabf12r 218 29 in in IN cord-337849-tyabf12r 218 30 the the DT cord-337849-tyabf12r 218 31 regulation regulation NN cord-337849-tyabf12r 218 32 of of IN cord-337849-tyabf12r 218 33 STAT-1 STAT-1 NNS cord-337849-tyabf12r 218 34 phosphorylation phosphorylation NN cord-337849-tyabf12r 218 35 resulting result VBG cord-337849-tyabf12r 218 36 in in IN cord-337849-tyabf12r 218 37 more more JJR cord-337849-tyabf12r 218 38 severe severe JJ cord-337849-tyabf12r 218 39 disease disease NN cord-337849-tyabf12r 218 40 . . . cord-337849-tyabf12r 219 1 It -PRON- PRP cord-337849-tyabf12r 219 2 has have VBZ cord-337849-tyabf12r 219 3 also also RB cord-337849-tyabf12r 219 4 been be VBN cord-337849-tyabf12r 219 5 demonstrated demonstrate VBN cord-337849-tyabf12r 219 6 that that IN cord-337849-tyabf12r 219 7 the the DT cord-337849-tyabf12r 219 8 antimicrobial antimicrobial JJ cord-337849-tyabf12r 219 9 peptides peptide NNS cord-337849-tyabf12r 219 10 LL-37 LL-37 NNP cord-337849-tyabf12r 219 11 and and CC cord-337849-tyabf12r 219 12 β β NNP cord-337849-tyabf12r 219 13 - - HYPH cord-337849-tyabf12r 219 14 defensin defensin NNP cord-337849-tyabf12r 219 15 2 2 CD cord-337849-tyabf12r 219 16 have have VBP cord-337849-tyabf12r 219 17 anti anti JJ cord-337849-tyabf12r 219 18 - - JJ cord-337849-tyabf12r 219 19 viral viral JJ cord-337849-tyabf12r 219 20 activity activity NN cord-337849-tyabf12r 219 21 against against IN cord-337849-tyabf12r 219 22 RSV RSV NNP cord-337849-tyabf12r 219 23 , , , cord-337849-tyabf12r 219 24 blocking block VBG cord-337849-tyabf12r 219 25 viral viral JJ cord-337849-tyabf12r 219 26 cellular cellular JJ cord-337849-tyabf12r 219 27 entry entry NN cord-337849-tyabf12r 219 28 , , , cord-337849-tyabf12r 219 29 preventing prevent VBG cord-337849-tyabf12r 219 30 virus virus NN cord-337849-tyabf12r 219 31 - - HYPH cord-337849-tyabf12r 219 32 induced induce VBN cord-337849-tyabf12r 219 33 epithelial epithelial JJ cord-337849-tyabf12r 219 34 cell cell NN cord-337849-tyabf12r 219 35 death death NN cord-337849-tyabf12r 219 36 , , , cord-337849-tyabf12r 219 37 inhibiting inhibit VBG cord-337849-tyabf12r 219 38 production production NN cord-337849-tyabf12r 219 39 of of IN cord-337849-tyabf12r 219 40 new new JJ cord-337849-tyabf12r 219 41 infectious infectious JJ cord-337849-tyabf12r 219 42 particles particle NNS cord-337849-tyabf12r 219 43 and and CC cord-337849-tyabf12r 219 44 diminishing diminish VBG cord-337849-tyabf12r 219 45 the the DT cord-337849-tyabf12r 219 46 spread spread NN cord-337849-tyabf12r 219 47 of of IN cord-337849-tyabf12r 219 48 infection infection NN cord-337849-tyabf12r 219 49 [ [ -LRB- cord-337849-tyabf12r 219 50 56 56 CD cord-337849-tyabf12r 219 51 , , , cord-337849-tyabf12r 219 52 121 121 CD cord-337849-tyabf12r 219 53 ] ] -RRB- cord-337849-tyabf12r 219 54 . . . cord-337849-tyabf12r 220 1 Since since IN cord-337849-tyabf12r 220 2 vitamin vitamin NN cord-337849-tyabf12r 220 3 D d NN cord-337849-tyabf12r 220 4 has have VBZ cord-337849-tyabf12r 220 5 been be VBN cord-337849-tyabf12r 220 6 demonstrated demonstrate VBN cord-337849-tyabf12r 220 7 to to TO cord-337849-tyabf12r 220 8 be be VB cord-337849-tyabf12r 220 9 able able JJ cord-337849-tyabf12r 220 10 to to TO cord-337849-tyabf12r 220 11 induce induce VB cord-337849-tyabf12r 220 12 secretion secretion NN cord-337849-tyabf12r 220 13 of of IN cord-337849-tyabf12r 220 14 both both DT cord-337849-tyabf12r 220 15 of of IN cord-337849-tyabf12r 220 16 these these DT cord-337849-tyabf12r 220 17 molecules molecule NNS cord-337849-tyabf12r 220 18 [ [ -LRB- cord-337849-tyabf12r 220 19 116 116 CD cord-337849-tyabf12r 220 20 ] ] -RRB- cord-337849-tyabf12r 220 21 [ [ -LRB- cord-337849-tyabf12r 220 22 117 117 CD cord-337849-tyabf12r 220 23 ] ] -RRB- cord-337849-tyabf12r 220 24 [ [ -LRB- cord-337849-tyabf12r 220 25 118 118 CD cord-337849-tyabf12r 220 26 ] ] -RRB- cord-337849-tyabf12r 220 27 , , , cord-337849-tyabf12r 220 28 this this DT cord-337849-tyabf12r 220 29 provides provide VBZ cord-337849-tyabf12r 220 30 a a DT cord-337849-tyabf12r 220 31 potential potential JJ cord-337849-tyabf12r 220 32 mechanism mechanism NN cord-337849-tyabf12r 220 33 by by IN cord-337849-tyabf12r 220 34 which which WDT cord-337849-tyabf12r 220 35 vitamin vitamin NN cord-337849-tyabf12r 220 36 D d NN cord-337849-tyabf12r 220 37 may may MD cord-337849-tyabf12r 220 38 exert exert VB cord-337849-tyabf12r 220 39 antiviral antiviral JJ cord-337849-tyabf12r 220 40 effects effect NNS cord-337849-tyabf12r 220 41 against against IN cord-337849-tyabf12r 220 42 RSV RSV NNP cord-337849-tyabf12r 220 43 infection infection NN cord-337849-tyabf12r 220 44 . . . cord-337849-tyabf12r 221 1 Finally finally RB cord-337849-tyabf12r 221 2 , , , cord-337849-tyabf12r 221 3 a a DT cord-337849-tyabf12r 221 4 number number NN cord-337849-tyabf12r 221 5 of of IN cord-337849-tyabf12r 221 6 studies study NNS cord-337849-tyabf12r 221 7 have have VBP cord-337849-tyabf12r 221 8 been be VBN cord-337849-tyabf12r 221 9 carried carry VBN cord-337849-tyabf12r 221 10 out out RP cord-337849-tyabf12r 221 11 in in IN cord-337849-tyabf12r 221 12 calves calf NNS cord-337849-tyabf12r 221 13 , , , cord-337849-tyabf12r 221 14 looking look VBG cord-337849-tyabf12r 221 15 at at IN cord-337849-tyabf12r 221 16 the the DT cord-337849-tyabf12r 221 17 association association NN cord-337849-tyabf12r 221 18 between between IN cord-337849-tyabf12r 221 19 vitamin vitamin NN cord-337849-tyabf12r 221 20 D d NN cord-337849-tyabf12r 221 21 and and CC cord-337849-tyabf12r 221 22 bovine bovine JJ cord-337849-tyabf12r 221 23 RSV RSV NNP cord-337849-tyabf12r 221 24 ( ( -LRB- cord-337849-tyabf12r 221 25 BRSV BRSV NNP cord-337849-tyabf12r 221 26 ) ) -RRB- cord-337849-tyabf12r 221 27 . . . cord-337849-tyabf12r 222 1 Naturally naturally RB cord-337849-tyabf12r 222 2 occurring occur VBG cord-337849-tyabf12r 222 3 BRSV BRSV NNP cord-337849-tyabf12r 222 4 infection infection NN cord-337849-tyabf12r 222 5 in in IN cord-337849-tyabf12r 222 6 young young JJ cord-337849-tyabf12r 222 7 ruminants ruminant NNS cord-337849-tyabf12r 222 8 has have VBZ cord-337849-tyabf12r 222 9 been be VBN cord-337849-tyabf12r 222 10 demonstrated demonstrate VBN cord-337849-tyabf12r 222 11 to to TO cord-337849-tyabf12r 222 12 mimic mimic VB cord-337849-tyabf12r 222 13 the the DT cord-337849-tyabf12r 222 14 pathogenesis pathogenesis NN cord-337849-tyabf12r 222 15 and and CC cord-337849-tyabf12r 222 16 lesions lesion NNS cord-337849-tyabf12r 222 17 observed observe VBN cord-337849-tyabf12r 222 18 in in IN cord-337849-tyabf12r 222 19 RSV RSV NNP cord-337849-tyabf12r 222 20 infection infection NN cord-337849-tyabf12r 222 21 of of IN cord-337849-tyabf12r 222 22 infants infant NNS cord-337849-tyabf12r 222 23 , , , cord-337849-tyabf12r 222 24 thus thus RB cord-337849-tyabf12r 222 25 providing provide VBG cord-337849-tyabf12r 222 26 a a DT cord-337849-tyabf12r 222 27 useful useful JJ cord-337849-tyabf12r 222 28 model model NN cord-337849-tyabf12r 222 29 for for IN cord-337849-tyabf12r 222 30 studying study VBG cord-337849-tyabf12r 222 31 RSV RSV NNP cord-337849-tyabf12r 222 32 infection infection NN cord-337849-tyabf12r 222 33 . . . cord-337849-tyabf12r 223 1 Conversely conversely RB cord-337849-tyabf12r 223 2 to to IN cord-337849-tyabf12r 223 3 the the DT cord-337849-tyabf12r 223 4 effects effect NNS cord-337849-tyabf12r 223 5 described describe VBN cord-337849-tyabf12r 223 6 above above RB cord-337849-tyabf12r 223 7 , , , cord-337849-tyabf12r 223 8 whereby whereby WRB cord-337849-tyabf12r 223 9 production production NN cord-337849-tyabf12r 223 10 of of IN cord-337849-tyabf12r 223 11 NF nf NN cord-337849-tyabf12r 223 12 - - HYPH cord-337849-tyabf12r 223 13 κB κB NNP cord-337849-tyabf12r 223 14 - - HYPH cord-337849-tyabf12r 223 15 linked link VBN cord-337849-tyabf12r 223 16 pro pro JJ cord-337849-tyabf12r 223 17 - - JJ cord-337849-tyabf12r 223 18 inflammatory inflammatory JJ cord-337849-tyabf12r 223 19 cytokines cytokine NNS cord-337849-tyabf12r 223 20 was be VBD cord-337849-tyabf12r 223 21 inhibited inhibit VBN cord-337849-tyabf12r 223 22 , , , cord-337849-tyabf12r 223 23 vitamin vitamin NN cord-337849-tyabf12r 223 24 D d NN cord-337849-tyabf12r 223 25 treatment treatment NN cord-337849-tyabf12r 223 26 has have VBZ cord-337849-tyabf12r 223 27 been be VBN cord-337849-tyabf12r 223 28 shown show VBN cord-337849-tyabf12r 223 29 to to TO cord-337849-tyabf12r 223 30 elevate elevate VB cord-337849-tyabf12r 223 31 secretion secretion NN cord-337849-tyabf12r 223 32 of of IN cord-337849-tyabf12r 223 33 the the DT cord-337849-tyabf12r 223 34 pro pro JJ cord-337849-tyabf12r 223 35 - - JJ cord-337849-tyabf12r 223 36 inflammatory inflammatory JJ cord-337849-tyabf12r 223 37 cytokine cytokine NN cord-337849-tyabf12r 223 38 IL-12p40 IL-12p40 NNP cord-337849-tyabf12r 223 39 following follow VBG cord-337849-tyabf12r 223 40 BRSV BRSV NNP cord-337849-tyabf12r 223 41 infection infection NN cord-337849-tyabf12r 223 42 [ [ -LRB- cord-337849-tyabf12r 223 43 189 189 CD cord-337849-tyabf12r 223 44 ] ] -RRB- cord-337849-tyabf12r 223 45 . . . cord-337849-tyabf12r 224 1 No no DT cord-337849-tyabf12r 224 2 effect effect NN cord-337849-tyabf12r 224 3 was be VBD cord-337849-tyabf12r 224 4 observed observe VBN cord-337849-tyabf12r 224 5 on on IN cord-337849-tyabf12r 224 6 γδ γδ NNP cord-337849-tyabf12r 224 7 T T NNP cord-337849-tyabf12r 224 8 - - HYPH cord-337849-tyabf12r 224 9 cell cell NN cord-337849-tyabf12r 224 10 cytokine cytokine NN cord-337849-tyabf12r 224 11 production production NN cord-337849-tyabf12r 224 12 [ [ -LRB- cord-337849-tyabf12r 224 13 190 190 CD cord-337849-tyabf12r 224 14 ] ] -RRB- cord-337849-tyabf12r 224 15 , , , cord-337849-tyabf12r 224 16 or or CC cord-337849-tyabf12r 224 17 IFN IFN NNP cord-337849-tyabf12r 224 18 - - HYPH cord-337849-tyabf12r 224 19 γ γ NNP cord-337849-tyabf12r 224 20 , , , cord-337849-tyabf12r 224 21 CXCL8 CXCL8 NNP cord-337849-tyabf12r 224 22 , , , cord-337849-tyabf12r 224 23 TNF TNF NNP cord-337849-tyabf12r 224 24 - - HYPH cord-337849-tyabf12r 224 25 α α NNP cord-337849-tyabf12r 224 26 , , , cord-337849-tyabf12r 224 27 IL-1β IL-1β NNP cord-337849-tyabf12r 224 28 or or CC cord-337849-tyabf12r 224 29 IL-6 IL-6 NNP cord-337849-tyabf12r 224 30 secretion secretion NN cord-337849-tyabf12r 224 31 [ [ -LRB- cord-337849-tyabf12r 224 32 189 189 CD cord-337849-tyabf12r 224 33 ] ] -RRB- cord-337849-tyabf12r 224 34 . . . cord-337849-tyabf12r 225 1 The the DT cord-337849-tyabf12r 225 2 influenza influenza NN cord-337849-tyabf12r 225 3 virus virus NN cord-337849-tyabf12r 225 4 is be VBZ cord-337849-tyabf12r 225 5 associated associate VBN cord-337849-tyabf12r 225 6 with with IN cord-337849-tyabf12r 225 7 seasonal seasonal JJ cord-337849-tyabf12r 225 8 epidemics epidemic NNS cord-337849-tyabf12r 225 9 , , , cord-337849-tyabf12r 225 10 severe severe JJ cord-337849-tyabf12r 225 11 pandemics pandemic NNS cord-337849-tyabf12r 225 12 , , , cord-337849-tyabf12r 225 13 pneumonia pneumonia NN cord-337849-tyabf12r 225 14 and and CC cord-337849-tyabf12r 225 15 secondary secondary JJ cord-337849-tyabf12r 225 16 bacterial bacterial JJ cord-337849-tyabf12r 225 17 infections infection NNS cord-337849-tyabf12r 225 18 . . . cord-337849-tyabf12r 226 1 As as IN cord-337849-tyabf12r 226 2 such such JJ cord-337849-tyabf12r 226 3 , , , cord-337849-tyabf12r 226 4 a a DT cord-337849-tyabf12r 226 5 simple simple JJ cord-337849-tyabf12r 226 6 and and CC cord-337849-tyabf12r 226 7 cost cost NN cord-337849-tyabf12r 226 8 - - HYPH cord-337849-tyabf12r 226 9 effective effective JJ cord-337849-tyabf12r 226 10 prevention prevention NN cord-337849-tyabf12r 226 11 strategy strategy NN cord-337849-tyabf12r 226 12 is be VBZ cord-337849-tyabf12r 226 13 desirable desirable JJ cord-337849-tyabf12r 226 14 , , , cord-337849-tyabf12r 226 15 with with IN cord-337849-tyabf12r 226 16 clinical clinical JJ cord-337849-tyabf12r 226 17 trial trial NN cord-337849-tyabf12r 226 18 results result NNS cord-337849-tyabf12r 226 19 showing show VBG cord-337849-tyabf12r 226 20 promising promising JJ cord-337849-tyabf12r 226 21 effects effect NNS cord-337849-tyabf12r 226 22 of of IN cord-337849-tyabf12r 226 23 vitamin vitamin NN cord-337849-tyabf12r 226 24 D d NN cord-337849-tyabf12r 226 25 supplementation supplementation NN cord-337849-tyabf12r 226 26 in in IN cord-337849-tyabf12r 226 27 the the DT cord-337849-tyabf12r 226 28 prevention prevention NN cord-337849-tyabf12r 226 29 of of IN cord-337849-tyabf12r 226 30 seasonal seasonal JJ cord-337849-tyabf12r 226 31 influenza influenza NN cord-337849-tyabf12r 226 32 A a DT cord-337849-tyabf12r 226 33 infection infection NN cord-337849-tyabf12r 226 34 in in IN cord-337849-tyabf12r 226 35 Japanese japanese JJ cord-337849-tyabf12r 226 36 schoolchildren schoolchildren NNS cord-337849-tyabf12r 226 37 [ [ -LRB- cord-337849-tyabf12r 226 38 17 17 CD cord-337849-tyabf12r 226 39 ] ] -RRB- cord-337849-tyabf12r 226 40 . . . cord-337849-tyabf12r 227 1 However however RB cord-337849-tyabf12r 227 2 , , , cord-337849-tyabf12r 227 3 as as IN cord-337849-tyabf12r 227 4 with with IN cord-337849-tyabf12r 227 5 RSV RSV NNP cord-337849-tyabf12r 227 6 and and CC cord-337849-tyabf12r 227 7 rhinovirus rhinovirus NN cord-337849-tyabf12r 227 8 , , , cord-337849-tyabf12r 227 9 in in IN cord-337849-tyabf12r 227 10 vitro vitro FW cord-337849-tyabf12r 227 11 work work NN cord-337849-tyabf12r 227 12 investigating investigate VBG cord-337849-tyabf12r 227 13 the the DT cord-337849-tyabf12r 227 14 specific specific JJ cord-337849-tyabf12r 227 15 effects effect NNS cord-337849-tyabf12r 227 16 of of IN cord-337849-tyabf12r 227 17 vitamin vitamin NN cord-337849-tyabf12r 227 18 D d NN cord-337849-tyabf12r 227 19 on on IN cord-337849-tyabf12r 227 20 the the DT cord-337849-tyabf12r 227 21 immune immune JJ cord-337849-tyabf12r 227 22 response response NN cord-337849-tyabf12r 227 23 to to IN cord-337849-tyabf12r 227 24 influenza influenza NN cord-337849-tyabf12r 227 25 viruses virus NNS cord-337849-tyabf12r 227 26 is be VBZ cord-337849-tyabf12r 227 27 lacking lack VBG cord-337849-tyabf12r 227 28 . . . cord-337849-tyabf12r 228 1 In in IN cord-337849-tyabf12r 228 2 a a DT cord-337849-tyabf12r 228 3 study study NN cord-337849-tyabf12r 228 4 using use VBG cord-337849-tyabf12r 228 5 alveolar alveolar NN cord-337849-tyabf12r 228 6 A549 a549 JJ cord-337849-tyabf12r 228 7 cells cell NNS cord-337849-tyabf12r 228 8 , , , cord-337849-tyabf12r 228 9 the the DT cord-337849-tyabf12r 228 10 effect effect NN cord-337849-tyabf12r 228 11 of of IN cord-337849-tyabf12r 228 12 pre pre JJ cord-337849-tyabf12r 228 13 - - JJ cord-337849-tyabf12r 228 14 or or CC cord-337849-tyabf12r 228 15 post post JJ cord-337849-tyabf12r 228 16 - - NN cord-337849-tyabf12r 228 17 treatment treatment NN cord-337849-tyabf12r 228 18 with with IN cord-337849-tyabf12r 228 19 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 228 20 on on IN cord-337849-tyabf12r 228 21 infection infection NN cord-337849-tyabf12r 228 22 with with IN cord-337849-tyabf12r 228 23 influenza influenza NN cord-337849-tyabf12r 228 24 A a DT cord-337849-tyabf12r 228 25 H1N1 H1N1 NNP cord-337849-tyabf12r 228 26 was be VBD cord-337849-tyabf12r 228 27 assessed assess VBN cord-337849-tyabf12r 228 28 [ [ -LRB- cord-337849-tyabf12r 228 29 191 191 CD cord-337849-tyabf12r 228 30 ] ] -RRB- cord-337849-tyabf12r 228 31 . . . cord-337849-tyabf12r 229 1 It -PRON- PRP cord-337849-tyabf12r 229 2 was be VBD cord-337849-tyabf12r 229 3 demonstrated demonstrate VBN cord-337849-tyabf12r 229 4 that that IN cord-337849-tyabf12r 229 5 vitamin vitamin NN cord-337849-tyabf12r 229 6 D d NN cord-337849-tyabf12r 229 7 had have VBD cord-337849-tyabf12r 229 8 no no DT cord-337849-tyabf12r 229 9 effect effect NN cord-337849-tyabf12r 229 10 on on IN cord-337849-tyabf12r 229 11 A549 a549 JJ cord-337849-tyabf12r 229 12 cell cell NN cord-337849-tyabf12r 229 13 viability viability NN cord-337849-tyabf12r 229 14 following follow VBG cord-337849-tyabf12r 229 15 infection infection NN cord-337849-tyabf12r 229 16 with with IN cord-337849-tyabf12r 229 17 influenza influenza NN cord-337849-tyabf12r 229 18 virus virus NN cord-337849-tyabf12r 229 19 , , , cord-337849-tyabf12r 229 20 viral viral JJ cord-337849-tyabf12r 229 21 clearance clearance NN cord-337849-tyabf12r 229 22 or or CC cord-337849-tyabf12r 229 23 the the DT cord-337849-tyabf12r 229 24 anti anti JJ cord-337849-tyabf12r 229 25 - - JJ cord-337849-tyabf12r 229 26 viral viral JJ cord-337849-tyabf12r 229 27 state state NN cord-337849-tyabf12r 229 28 . . . cord-337849-tyabf12r 230 1 Whilst whilst IN cord-337849-tyabf12r 230 2 influenza influenza NN cord-337849-tyabf12r 230 3 infection infection NN cord-337849-tyabf12r 230 4 increased increase VBD cord-337849-tyabf12r 230 5 the the DT cord-337849-tyabf12r 230 6 production production NN cord-337849-tyabf12r 230 7 of of IN cord-337849-tyabf12r 230 8 pro pro JJ cord-337849-tyabf12r 230 9 - - JJ cord-337849-tyabf12r 230 10 inflammatory inflammatory JJ cord-337849-tyabf12r 230 11 cytokines cytokine NNS cord-337849-tyabf12r 230 12 and and CC cord-337849-tyabf12r 230 13 chemokines chemokine NNS cord-337849-tyabf12r 230 14 , , , cord-337849-tyabf12r 230 15 as as IN cord-337849-tyabf12r 230 16 with with IN cord-337849-tyabf12r 230 17 RSV RSV NNP cord-337849-tyabf12r 230 18 infection infection NN cord-337849-tyabf12r 230 19 [ [ -LRB- cord-337849-tyabf12r 230 20 187 187 CD cord-337849-tyabf12r 230 21 , , , cord-337849-tyabf12r 230 22 188 188 CD cord-337849-tyabf12r 230 23 ] ] -RRB- cord-337849-tyabf12r 230 24 , , , cord-337849-tyabf12r 230 25 treatment treatment NN cord-337849-tyabf12r 230 26 with with IN cord-337849-tyabf12r 230 27 vitamin vitamin NN cord-337849-tyabf12r 230 28 D d NN cord-337849-tyabf12r 230 29 either either CC cord-337849-tyabf12r 230 30 before before IN cord-337849-tyabf12r 230 31 or or CC cord-337849-tyabf12r 230 32 after after IN cord-337849-tyabf12r 230 33 influenza influenza NN cord-337849-tyabf12r 230 34 infection infection NN cord-337849-tyabf12r 230 35 decreased decrease VBD cord-337849-tyabf12r 230 36 gene gene NN cord-337849-tyabf12r 230 37 expression expression NN cord-337849-tyabf12r 230 38 of of IN cord-337849-tyabf12r 230 39 TNF TNF NNP cord-337849-tyabf12r 230 40 - - HYPH cord-337849-tyabf12r 230 41 α α NNP cord-337849-tyabf12r 230 42 , , , cord-337849-tyabf12r 230 43 IFN IFN NNP cord-337849-tyabf12r 230 44 - - HYPH cord-337849-tyabf12r 230 45 β β NNP cord-337849-tyabf12r 230 46 , , , cord-337849-tyabf12r 230 47 ISG15 ISG15 NNP cord-337849-tyabf12r 230 48 , , , cord-337849-tyabf12r 230 49 CXCL8 CXCL8 NNP cord-337849-tyabf12r 230 50 , , , cord-337849-tyabf12r 230 51 IL-6 IL-6 NNP cord-337849-tyabf12r 230 52 and and CC cord-337849-tyabf12r 230 53 RANTES RANTES NNP cord-337849-tyabf12r 230 54 ( ( -LRB- cord-337849-tyabf12r 230 55 CCL5 CCL5 NNP cord-337849-tyabf12r 230 56 ) ) -RRB- cord-337849-tyabf12r 230 57 . . . cord-337849-tyabf12r 231 1 Since since IN cord-337849-tyabf12r 231 2 an an DT cord-337849-tyabf12r 231 3 uncontrolled uncontrolled JJ cord-337849-tyabf12r 231 4 inflammatory inflammatory JJ cord-337849-tyabf12r 231 5 response response NN cord-337849-tyabf12r 231 6 to to IN cord-337849-tyabf12r 231 7 influenza influenza NN cord-337849-tyabf12r 231 8 infection infection NN cord-337849-tyabf12r 231 9 can can MD cord-337849-tyabf12r 231 10 cause cause VB cord-337849-tyabf12r 231 11 complications complication NNS cord-337849-tyabf12r 231 12 such such JJ cord-337849-tyabf12r 231 13 as as IN cord-337849-tyabf12r 231 14 pulmonary pulmonary JJ cord-337849-tyabf12r 231 15 oedema oedema NN cord-337849-tyabf12r 231 16 , , , cord-337849-tyabf12r 231 17 and and CC cord-337849-tyabf12r 231 18 the the DT cord-337849-tyabf12r 231 19 cytokine cytokine NN cord-337849-tyabf12r 231 20 storm storm NN cord-337849-tyabf12r 231 21 has have VBZ cord-337849-tyabf12r 231 22 been be VBN cord-337849-tyabf12r 231 23 associated associate VBN cord-337849-tyabf12r 231 24 with with IN cord-337849-tyabf12r 231 25 more more RBR cord-337849-tyabf12r 231 26 severe severe JJ cord-337849-tyabf12r 231 27 disease disease NN cord-337849-tyabf12r 231 28 and and CC cord-337849-tyabf12r 231 29 higher high JJR cord-337849-tyabf12r 231 30 mortality mortality NN cord-337849-tyabf12r 231 31 [ [ -LRB- cord-337849-tyabf12r 231 32 192 192 CD cord-337849-tyabf12r 231 33 ] ] -RRB- cord-337849-tyabf12r 231 34 ) ) -RRB- cord-337849-tyabf12r 231 35 , , , cord-337849-tyabf12r 231 36 this this DT cord-337849-tyabf12r 231 37 suppression suppression NN cord-337849-tyabf12r 231 38 of of IN cord-337849-tyabf12r 231 39 the the DT cord-337849-tyabf12r 231 40 hyper hyper JJ cord-337849-tyabf12r 231 41 - - JJ cord-337849-tyabf12r 231 42 inflammatory inflammatory JJ cord-337849-tyabf12r 231 43 response response NN cord-337849-tyabf12r 231 44 may may MD cord-337849-tyabf12r 231 45 be be VB cord-337849-tyabf12r 231 46 beneficial beneficial JJ cord-337849-tyabf12r 231 47 in in IN cord-337849-tyabf12r 231 48 preventing prevent VBG cord-337849-tyabf12r 231 49 immunopathology immunopathology NN cord-337849-tyabf12r 231 50 . . . cord-337849-tyabf12r 232 1 The the DT cord-337849-tyabf12r 232 2 antimicrobial antimicrobial JJ cord-337849-tyabf12r 232 3 peptides peptide NNS cord-337849-tyabf12r 232 4 LL-37 LL-37 NNP cord-337849-tyabf12r 232 5 and and CC cord-337849-tyabf12r 232 6 human human JJ cord-337849-tyabf12r 232 7 β β NNP cord-337849-tyabf12r 232 8 - - HYPH cord-337849-tyabf12r 232 9 defensin defensin NNP cord-337849-tyabf12r 232 10 2 2 CD cord-337849-tyabf12r 232 11 have have VBP cord-337849-tyabf12r 232 12 also also RB cord-337849-tyabf12r 232 13 been be VBN cord-337849-tyabf12r 232 14 shown show VBN cord-337849-tyabf12r 232 15 to to TO cord-337849-tyabf12r 232 16 have have VB cord-337849-tyabf12r 232 17 anti anti JJ cord-337849-tyabf12r 232 18 - - JJ cord-337849-tyabf12r 232 19 viral viral JJ cord-337849-tyabf12r 232 20 properties property NNS cord-337849-tyabf12r 232 21 against against IN cord-337849-tyabf12r 232 22 influenza influenza NN cord-337849-tyabf12r 232 23 virus virus NN cord-337849-tyabf12r 232 24 , , , cord-337849-tyabf12r 232 25 reducing reduce VBG cord-337849-tyabf12r 232 26 disease disease NN cord-337849-tyabf12r 232 27 severity severity NN cord-337849-tyabf12r 232 28 and and CC cord-337849-tyabf12r 232 29 viral viral JJ cord-337849-tyabf12r 232 30 replication replication NN cord-337849-tyabf12r 232 31 , , , cord-337849-tyabf12r 232 32 inhibiting inhibit VBG cord-337849-tyabf12r 232 33 infectivity infectivity NN cord-337849-tyabf12r 232 34 , , , cord-337849-tyabf12r 232 35 and and CC cord-337849-tyabf12r 232 36 demonstrating demonstrate VBG cord-337849-tyabf12r 232 37 neutralising neutralise VBG cord-337849-tyabf12r 232 38 activity activity NN cord-337849-tyabf12r 232 39 [ [ -LRB- cord-337849-tyabf12r 232 40 54 54 CD cord-337849-tyabf12r 232 41 , , , cord-337849-tyabf12r 232 42 193 193 CD cord-337849-tyabf12r 232 43 ] ] -RRB- cord-337849-tyabf12r 232 44 . . . cord-337849-tyabf12r 233 1 As as IN cord-337849-tyabf12r 233 2 described describe VBN cord-337849-tyabf12r 233 3 above above RB cord-337849-tyabf12r 233 4 , , , cord-337849-tyabf12r 233 5 since since IN cord-337849-tyabf12r 233 6 vitamin vitamin NN cord-337849-tyabf12r 233 7 D d NN cord-337849-tyabf12r 233 8 has have VBZ cord-337849-tyabf12r 233 9 been be VBN cord-337849-tyabf12r 233 10 shown show VBN cord-337849-tyabf12r 233 11 to to TO cord-337849-tyabf12r 233 12 induce induce VB cord-337849-tyabf12r 233 13 production production NN cord-337849-tyabf12r 233 14 of of IN cord-337849-tyabf12r 233 15 these these DT cord-337849-tyabf12r 233 16 AMPs amp NNS cord-337849-tyabf12r 233 17 , , , cord-337849-tyabf12r 233 18 this this DT cord-337849-tyabf12r 233 19 may may MD cord-337849-tyabf12r 233 20 be be VB cord-337849-tyabf12r 233 21 another another DT cord-337849-tyabf12r 233 22 mechanism mechanism NN cord-337849-tyabf12r 233 23 by by IN cord-337849-tyabf12r 233 24 which which WDT cord-337849-tyabf12r 233 25 vitamin vitamin NN cord-337849-tyabf12r 233 26 D d NN cord-337849-tyabf12r 233 27 is be VBZ cord-337849-tyabf12r 233 28 able able JJ cord-337849-tyabf12r 233 29 to to TO cord-337849-tyabf12r 233 30 exert exert VB cord-337849-tyabf12r 233 31 antiviral antiviral JJ cord-337849-tyabf12r 233 32 effects effect NNS cord-337849-tyabf12r 233 33 on on IN cord-337849-tyabf12r 233 34 influenza influenza NN cord-337849-tyabf12r 233 35 virus virus NN cord-337849-tyabf12r 233 36 infection infection NN cord-337849-tyabf12r 233 37 . . . cord-337849-tyabf12r 234 1 Finally finally RB cord-337849-tyabf12r 234 2 , , , cord-337849-tyabf12r 234 3 the the DT cord-337849-tyabf12r 234 4 majority majority NN cord-337849-tyabf12r 234 5 of of IN cord-337849-tyabf12r 234 6 work work NN cord-337849-tyabf12r 234 7 into into IN cord-337849-tyabf12r 234 8 vitamin vitamin NN cord-337849-tyabf12r 234 9 D d NN cord-337849-tyabf12r 234 10 and and CC cord-337849-tyabf12r 234 11 influenza influenza NN cord-337849-tyabf12r 234 12 infection infection NN cord-337849-tyabf12r 234 13 has have VBZ cord-337849-tyabf12r 234 14 been be VBN cord-337849-tyabf12r 234 15 investigating investigate VBG cord-337849-tyabf12r 234 16 the the DT cord-337849-tyabf12r 234 17 potential potential JJ cord-337849-tyabf12r 234 18 use use NN cord-337849-tyabf12r 234 19 of of IN cord-337849-tyabf12r 234 20 vitamin vitamin NN cord-337849-tyabf12r 234 21 D d NN cord-337849-tyabf12r 234 22 as as IN cord-337849-tyabf12r 234 23 an an DT cord-337849-tyabf12r 234 24 adjuvant adjuvant NN cord-337849-tyabf12r 234 25 in in IN cord-337849-tyabf12r 234 26 influenza influenza NN cord-337849-tyabf12r 234 27 vaccines vaccine NNS cord-337849-tyabf12r 234 28 . . . cord-337849-tyabf12r 235 1 However however RB cord-337849-tyabf12r 235 2 , , , cord-337849-tyabf12r 235 3 vitamin vitamin NN cord-337849-tyabf12r 235 4 D d NN cord-337849-tyabf12r 235 5 has have VBZ cord-337849-tyabf12r 235 6 not not RB cord-337849-tyabf12r 235 7 been be VBN cord-337849-tyabf12r 235 8 shown show VBN cord-337849-tyabf12r 235 9 to to TO cord-337849-tyabf12r 235 10 be be VB cord-337849-tyabf12r 235 11 able able JJ cord-337849-tyabf12r 235 12 to to TO cord-337849-tyabf12r 235 13 modulate modulate VB cord-337849-tyabf12r 235 14 the the DT cord-337849-tyabf12r 235 15 humoral humoral JJ cord-337849-tyabf12r 235 16 response response NN cord-337849-tyabf12r 235 17 to to IN cord-337849-tyabf12r 235 18 inactivated inactivate VBN cord-337849-tyabf12r 235 19 influenza influenza NN cord-337849-tyabf12r 235 20 virus virus NN cord-337849-tyabf12r 235 21 in in IN cord-337849-tyabf12r 235 22 this this DT cord-337849-tyabf12r 235 23 setting setting NN cord-337849-tyabf12r 235 24 [ [ -LRB- cord-337849-tyabf12r 235 25 194 194 CD cord-337849-tyabf12r 235 26 ] ] -RRB- cord-337849-tyabf12r 235 27 [ [ -LRB- cord-337849-tyabf12r 235 28 195 195 CD cord-337849-tyabf12r 235 29 ] ] -RRB- cord-337849-tyabf12r 235 30 [ [ -LRB- cord-337849-tyabf12r 235 31 196 196 CD cord-337849-tyabf12r 235 32 ] ] -RRB- cord-337849-tyabf12r 235 33 [ [ -LRB- cord-337849-tyabf12r 235 34 197 197 CD cord-337849-tyabf12r 235 35 ] ] -RRB- cord-337849-tyabf12r 235 36 [ [ -LRB- cord-337849-tyabf12r 235 37 198 198 CD cord-337849-tyabf12r 235 38 ] ] -RRB- cord-337849-tyabf12r 235 39 . . . cord-337849-tyabf12r 236 1 In in IN cord-337849-tyabf12r 236 2 the the DT cord-337849-tyabf12r 236 3 case case NN cord-337849-tyabf12r 236 4 of of IN cord-337849-tyabf12r 236 5 other other JJ cord-337849-tyabf12r 236 6 common common JJ cord-337849-tyabf12r 236 7 viral viral JJ cord-337849-tyabf12r 236 8 causes cause NNS cord-337849-tyabf12r 236 9 of of IN cord-337849-tyabf12r 236 10 ARI ARI NNP cord-337849-tyabf12r 236 11 in in IN cord-337849-tyabf12r 236 12 humans human NNS cord-337849-tyabf12r 236 13 , , , cord-337849-tyabf12r 236 14 no no UH cord-337849-tyabf12r 236 15 in in FW cord-337849-tyabf12r 236 16 vitro vitro FW cord-337849-tyabf12r 236 17 studies study NNS cord-337849-tyabf12r 236 18 have have VBP cord-337849-tyabf12r 236 19 been be VBN cord-337849-tyabf12r 236 20 carried carry VBN cord-337849-tyabf12r 236 21 out out RP cord-337849-tyabf12r 236 22 to to TO cord-337849-tyabf12r 236 23 determine determine VB cord-337849-tyabf12r 236 24 effects effect NNS cord-337849-tyabf12r 236 25 of of IN cord-337849-tyabf12r 236 26 vitamin vitamin NN cord-337849-tyabf12r 236 27 D d NN cord-337849-tyabf12r 236 28 on on IN cord-337849-tyabf12r 236 29 the the DT cord-337849-tyabf12r 236 30 immune immune JJ cord-337849-tyabf12r 236 31 response response NN cord-337849-tyabf12r 236 32 to to IN cord-337849-tyabf12r 236 33 these these DT cord-337849-tyabf12r 236 34 pathogens pathogen NNS cord-337849-tyabf12r 236 35 . . . cord-337849-tyabf12r 237 1 This this DT cord-337849-tyabf12r 237 2 is be VBZ cord-337849-tyabf12r 237 3 the the DT cord-337849-tyabf12r 237 4 case case NN cord-337849-tyabf12r 237 5 for for IN cord-337849-tyabf12r 237 6 human human NN cord-337849-tyabf12r 237 7 metapneumovirus metapneumovirus NNP cord-337849-tyabf12r 237 8 , , , cord-337849-tyabf12r 237 9 parainfluenza parainfluenza NNP cord-337849-tyabf12r 237 10 , , , cord-337849-tyabf12r 237 11 adenovirus adenovirus NN cord-337849-tyabf12r 237 12 , , , cord-337849-tyabf12r 237 13 coronaviruses coronaviruse NNS cord-337849-tyabf12r 237 14 , , , cord-337849-tyabf12r 237 15 enterovirus enterovirus NN cord-337849-tyabf12r 237 16 and and CC cord-337849-tyabf12r 237 17 human human JJ cord-337849-tyabf12r 237 18 bocavirus bocavirus NN cord-337849-tyabf12r 237 19 . . . cord-337849-tyabf12r 238 1 This this DT cord-337849-tyabf12r 238 2 review review NN cord-337849-tyabf12r 238 3 has have VBZ cord-337849-tyabf12r 238 4 identified identify VBN cord-337849-tyabf12r 238 5 a a DT cord-337849-tyabf12r 238 6 modest modest JJ cord-337849-tyabf12r 238 7 number number NN cord-337849-tyabf12r 238 8 of of IN cord-337849-tyabf12r 238 9 laboratory laboratory NN cord-337849-tyabf12r 238 10 studies study NNS cord-337849-tyabf12r 238 11 investigating investigate VBG cord-337849-tyabf12r 238 12 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 238 13 effects effect NNS cord-337849-tyabf12r 238 14 of of IN cord-337849-tyabf12r 238 15 vitamin vitamin NN cord-337849-tyabf12r 238 16 D d NN cord-337849-tyabf12r 238 17 metabolites metabolite NNS cord-337849-tyabf12r 238 18 in in IN cord-337849-tyabf12r 238 19 respiratory respiratory JJ cord-337849-tyabf12r 238 20 epithelial epithelial JJ cord-337849-tyabf12r 238 21 cells cell NNS cord-337849-tyabf12r 238 22 infected infect VBN cord-337849-tyabf12r 238 23 with with IN cord-337849-tyabf12r 238 24 respiratory respiratory JJ cord-337849-tyabf12r 238 25 viruses virus NNS cord-337849-tyabf12r 238 26 . . . cord-337849-tyabf12r 239 1 Despite despite IN cord-337849-tyabf12r 239 2 clinical clinical JJ cord-337849-tyabf12r 239 3 evidence evidence NN cord-337849-tyabf12r 239 4 that that IN cord-337849-tyabf12r 239 5 vitamin vitamin NN cord-337849-tyabf12r 239 6 D D NNP cord-337849-tyabf12r 239 7 supplementation supplementation NN cord-337849-tyabf12r 239 8 may may MD cord-337849-tyabf12r 239 9 reduce reduce VB cord-337849-tyabf12r 239 10 susceptibility susceptibility NN cord-337849-tyabf12r 239 11 to to IN cord-337849-tyabf12r 239 12 such such JJ cord-337849-tyabf12r 239 13 infections infection NNS cord-337849-tyabf12r 239 14 in in IN cord-337849-tyabf12r 239 15 vivo vivo NN cord-337849-tyabf12r 239 16 [ [ -LRB- cord-337849-tyabf12r 239 17 28 28 CD cord-337849-tyabf12r 239 18 ] ] -RRB- cord-337849-tyabf12r 239 19 , , , cord-337849-tyabf12r 239 20 in in IN cord-337849-tyabf12r 239 21 vitro vitro FW cord-337849-tyabf12r 239 22 studies study NNS cord-337849-tyabf12r 239 23 performed perform VBN cord-337849-tyabf12r 239 24 to to IN cord-337849-tyabf12r 239 25 date date NN cord-337849-tyabf12r 239 26 have have VBP cord-337849-tyabf12r 239 27 not not RB cord-337849-tyabf12r 239 28 shown show VBN cord-337849-tyabf12r 239 29 that that IN cord-337849-tyabf12r 239 30 vitamin vitamin NN cord-337849-tyabf12r 239 31 D d NN cord-337849-tyabf12r 239 32 metabolites metabolite NNS cord-337849-tyabf12r 239 33 inhibit inhibit VBP cord-337849-tyabf12r 239 34 viral viral JJ cord-337849-tyabf12r 239 35 replication replication NN cord-337849-tyabf12r 239 36 in in IN cord-337849-tyabf12r 239 37 epithelial epithelial JJ cord-337849-tyabf12r 239 38 cells cell NNS cord-337849-tyabf12r 239 39 . . . cord-337849-tyabf12r 240 1 However however RB cord-337849-tyabf12r 240 2 , , , cord-337849-tyabf12r 240 3 all all PDT cord-337849-tyabf12r 240 4 the the DT cord-337849-tyabf12r 240 5 studies study NNS cord-337849-tyabf12r 240 6 reviewed review VBN cord-337849-tyabf12r 240 7 demonstrated demonstrate VBD cord-337849-tyabf12r 240 8 effects effect NNS cord-337849-tyabf12r 240 9 of of IN cord-337849-tyabf12r 240 10 vitamin vitamin NN cord-337849-tyabf12r 240 11 D d NN cord-337849-tyabf12r 240 12 metabolites metabolite NNS cord-337849-tyabf12r 240 13 on on IN cord-337849-tyabf12r 240 14 expression expression NN cord-337849-tyabf12r 240 15 and and CC cord-337849-tyabf12r 240 16 secretion secretion NN cord-337849-tyabf12r 240 17 of of IN cord-337849-tyabf12r 240 18 pro pro JJ cord-337849-tyabf12r 240 19 - - JJ cord-337849-tyabf12r 240 20 inflammatory inflammatory JJ cord-337849-tyabf12r 240 21 cytokines cytokine NNS cord-337849-tyabf12r 240 22 and and CC cord-337849-tyabf12r 240 23 chemokines chemokine NNS cord-337849-tyabf12r 240 24 . . . cord-337849-tyabf12r 241 1 Interestingly interestingly RB cord-337849-tyabf12r 241 2 , , , cord-337849-tyabf12r 241 3 the the DT cord-337849-tyabf12r 241 4 effects effect NNS cord-337849-tyabf12r 241 5 of of IN cord-337849-tyabf12r 241 6 1,25(OH)2D 1,25(oh)2d CD cord-337849-tyabf12r 241 7 on on IN cord-337849-tyabf12r 241 8 chemokine chemokine JJ cord-337849-tyabf12r 241 9 expression expression NN cord-337849-tyabf12r 241 10 and and CC cord-337849-tyabf12r 241 11 secretion secretion NN cord-337849-tyabf12r 241 12 varied vary VBN cord-337849-tyabf12r 241 13 between between IN cord-337849-tyabf12r 241 14 pathogens pathogen NNS cord-337849-tyabf12r 241 15 ; ; : cord-337849-tyabf12r 241 16 this this DT cord-337849-tyabf12r 241 17 finding finding NN cord-337849-tyabf12r 241 18 complements complement VBZ cord-337849-tyabf12r 241 19 those those DT cord-337849-tyabf12r 241 20 of of IN cord-337849-tyabf12r 241 21 clinical clinical JJ cord-337849-tyabf12r 241 22 trials trial NNS cord-337849-tyabf12r 241 23 suggesting suggest VBG cord-337849-tyabf12r 241 24 that that IN cord-337849-tyabf12r 241 25 vitamin vitamin NN cord-337849-tyabf12r 241 26 D d NN cord-337849-tyabf12r 241 27 - - HYPH cord-337849-tyabf12r 241 28 inducible inducible JJ cord-337849-tyabf12r 241 29 responses response NNS cord-337849-tyabf12r 241 30 may may MD cord-337849-tyabf12r 241 31 be be VB cord-337849-tyabf12r 241 32 more more RBR cord-337849-tyabf12r 241 33 effective effective JJ cord-337849-tyabf12r 241 34 against against IN cord-337849-tyabf12r 241 35 some some DT cord-337849-tyabf12r 241 36 pathogens pathogen NNS cord-337849-tyabf12r 241 37 than than IN cord-337849-tyabf12r 241 38 others other NNS cord-337849-tyabf12r 241 39 [ [ -LRB- cord-337849-tyabf12r 241 40 17 17 CD cord-337849-tyabf12r 241 41 ] ] -RRB- cord-337849-tyabf12r 241 42 . . . cord-337849-tyabf12r 242 1 More More JJR cord-337849-tyabf12r 242 2 studies study NNS cord-337849-tyabf12r 242 3 are be VBP cord-337849-tyabf12r 242 4 needed need VBN cord-337849-tyabf12r 242 5 to to TO cord-337849-tyabf12r 242 6 characterize characterize VB cord-337849-tyabf12r 242 7 the the DT cord-337849-tyabf12r 242 8 in in FW cord-337849-tyabf12r 242 9 vitro vitro FW cord-337849-tyabf12r 242 10 actions action NNS cord-337849-tyabf12r 242 11 of of IN cord-337849-tyabf12r 242 12 vitamin vitamin NN cord-337849-tyabf12r 242 13 D d NN cord-337849-tyabf12r 242 14 in in IN cord-337849-tyabf12r 242 15 viral viral JJ cord-337849-tyabf12r 242 16 respiratory respiratory JJ cord-337849-tyabf12r 242 17 infection infection NN cord-337849-tyabf12r 242 18 ( ( -LRB- cord-337849-tyabf12r 242 19 particularly particularly RB cord-337849-tyabf12r 242 20 to to TO cord-337849-tyabf12r 242 21 investigate investigate VB cord-337849-tyabf12r 242 22 why why WRB cord-337849-tyabf12r 242 23 suppression suppression NN cord-337849-tyabf12r 242 24 of of IN cord-337849-tyabf12r 242 25 type type NN cord-337849-tyabf12r 242 26 1 1 CD cord-337849-tyabf12r 242 27 interferon interferon NN cord-337849-tyabf12r 242 28 responses response NNS cord-337849-tyabf12r 242 29 is be VBZ cord-337849-tyabf12r 242 30 not not RB cord-337849-tyabf12r 242 31 associated associate VBN cord-337849-tyabf12r 242 32 with with IN cord-337849-tyabf12r 242 33 increased increase VBN cord-337849-tyabf12r 242 34 viral viral JJ cord-337849-tyabf12r 242 35 replication replication NN cord-337849-tyabf12r 242 36 ) ) -RRB- cord-337849-tyabf12r 242 37 , , , cord-337849-tyabf12r 242 38 and and CC cord-337849-tyabf12r 242 39 to to TO cord-337849-tyabf12r 242 40 clarify clarify VB cord-337849-tyabf12r 242 41 the the DT cord-337849-tyabf12r 242 42 effects effect NNS cord-337849-tyabf12r 242 43 of of IN cord-337849-tyabf12r 242 44 vitamin vitamin NN cord-337849-tyabf12r 242 45 D d NN cord-337849-tyabf12r 242 46 metabolites metabolite NNS cord-337849-tyabf12r 242 47 on on IN cord-337849-tyabf12r 242 48 respiratory respiratory JJ cord-337849-tyabf12r 242 49 virus virus NN cord-337849-tyabf12r 242 50 - - HYPH cord-337849-tyabf12r 242 51 induced induce VBN cord-337849-tyabf12r 242 52 expression expression NN cord-337849-tyabf12r 242 53 of of IN cord-337849-tyabf12r 242 54 cell cell NN cord-337849-tyabf12r 242 55 surface surface NN cord-337849-tyabf12r 242 56 markers marker NNS cord-337849-tyabf12r 242 57 mediating mediate VBG cord-337849-tyabf12r 242 58 viral viral JJ cord-337849-tyabf12r 242 59 entry entry NN cord-337849-tyabf12r 242 60 and and CC cord-337849-tyabf12r 242 61 bacterial bacterial JJ cord-337849-tyabf12r 242 62 adhesion adhesion NN cord-337849-tyabf12r 242 63 to to IN cord-337849-tyabf12r 242 64 respiratory respiratory JJ cord-337849-tyabf12r 242 65 epithelial epithelial JJ cord-337849-tyabf12r 242 66 cells cell NNS cord-337849-tyabf12r 242 67 . . . cord-337849-tyabf12r 242 68 _SP cord-337849-tyabf12r 243 1 The the DT cord-337849-tyabf12r 243 2 manuscript manuscript NN cord-337849-tyabf12r 243 3 was be VBD cord-337849-tyabf12r 243 4 conceived conceive VBN cord-337849-tyabf12r 243 5 by by IN cord-337849-tyabf12r 243 6 both both DT cord-337849-tyabf12r 243 7 authors author NNS cord-337849-tyabf12r 243 8 . . . cord-337849-tyabf12r 244 1 CLG CLG NNP cord-337849-tyabf12r 244 2 wrote write VBD cord-337849-tyabf12r 244 3 the the DT cord-337849-tyabf12r 244 4 draft draft NN cord-337849-tyabf12r 244 5 manuscript manuscript NN cord-337849-tyabf12r 244 6 which which WDT cord-337849-tyabf12r 244 7 was be VBD cord-337849-tyabf12r 244 8 subsequently subsequently RB cord-337849-tyabf12r 244 9 edited edit VBN cord-337849-tyabf12r 244 10 by by IN cord-337849-tyabf12r 244 11 ARM arm NN cord-337849-tyabf12r 244 12 . . . cord-337849-tyabf12r 245 1 The the DT cord-337849-tyabf12r 245 2 authors author NNS cord-337849-tyabf12r 245 3 declare declare VBP cord-337849-tyabf12r 245 4 no no DT cord-337849-tyabf12r 245 5 conflict conflict NN cord-337849-tyabf12r 245 6 of of IN cord-337849-tyabf12r 245 7 interest interest NN cord-337849-tyabf12r 245 8 . . . cord-337849-tyabf12r 246 1 Picornavirus Picornavirus NNP cord-337849-tyabf12r 246 2 , , , cord-337849-tyabf12r 246 3 the the DT cord-337849-tyabf12r 246 4 most most RBS cord-337849-tyabf12r 246 5 common common JJ cord-337849-tyabf12r 246 6 respiratory respiratory JJ cord-337849-tyabf12r 246 7 virus virus NN cord-337849-tyabf12r 246 8 causing cause VBG cord-337849-tyabf12r 246 9 infection infection NN cord-337849-tyabf12r 246 10 among among IN cord-337849-tyabf12r 246 11 patients patient NNS cord-337849-tyabf12r 246 12 of of IN cord-337849-tyabf12r 246 13 all all DT cord-337849-tyabf12r 246 14 ages age NNS cord-337849-tyabf12r 246 15 hospitalized hospitalize VBN cord-337849-tyabf12r 246 16 with with IN cord-337849-tyabf12r 246 17 acute acute JJ cord-337849-tyabf12r 246 18 respiratory respiratory JJ cord-337849-tyabf12r 246 19 illness illness NN cord-337849-tyabf12r 246 20 Epidemiology Epidemiology NNP cord-337849-tyabf12r 246 21 of of IN cord-337849-tyabf12r 246 22 Human human JJ cord-337849-tyabf12r 246 23 Respiratory Respiratory NNP cord-337849-tyabf12r 246 24 Viruses Viruses NNPS cord-337849-tyabf12r 246 25 in in IN cord-337849-tyabf12r 246 26 Children child NNS cord-337849-tyabf12r 246 27 with with IN cord-337849-tyabf12r 246 28 Acute acute JJ cord-337849-tyabf12r 246 29 Respiratory respiratory JJ cord-337849-tyabf12r 246 30 Tract tract NN cord-337849-tyabf12r 246 31 Infections Infections NNPS cord-337849-tyabf12r 246 32 in in IN cord-337849-tyabf12r 246 33 Virological Virological NNP cord-337849-tyabf12r 246 34 and and CC cord-337849-tyabf12r 246 35 Clinical Clinical NNP cord-337849-tyabf12r 246 36 Characterizations Characterizations NNPS cord-337849-tyabf12r 246 37 of of IN cord-337849-tyabf12r 246 38 Respiratory respiratory JJ cord-337849-tyabf12r 246 39 Infections infection NNS cord-337849-tyabf12r 246 40 in in IN cord-337849-tyabf12r 246 41 Hospitalized Hospitalized NNP cord-337849-tyabf12r 246 42 Children Children NNPS cord-337849-tyabf12r 246 43 Incidence Incidence NNP cord-337849-tyabf12r 246 44 of of IN cord-337849-tyabf12r 246 45 Respiratory respiratory JJ cord-337849-tyabf12r 246 46 Viruses virus NNS cord-337849-tyabf12r 246 47 in in IN cord-337849-tyabf12r 246 48 Peruvian peruvian JJ cord-337849-tyabf12r 246 49 Children child NNS cord-337849-tyabf12r 246 50 with with IN cord-337849-tyabf12r 246 51 Acute acute JJ cord-337849-tyabf12r 246 52 Respiratory Respiratory NNP cord-337849-tyabf12r 246 53 Infections Infections NNPS cord-337849-tyabf12r 246 54 Human Human NNP cord-337849-tyabf12r 246 55 Bocavirus Bocavirus NNP cord-337849-tyabf12r 246 56 - - HYPH cord-337849-tyabf12r 246 57 infection infection NN cord-337849-tyabf12r 246 58 ( ( -LRB- cord-337849-tyabf12r 246 59 HBoV HBoV NNP cord-337849-tyabf12r 246 60 ) ) -RRB- cord-337849-tyabf12r 246 61 : : : cord-337849-tyabf12r 247 1 An an DT cord-337849-tyabf12r 247 2 important important JJ cord-337849-tyabf12r 247 3 cause cause NN cord-337849-tyabf12r 247 4 of of IN cord-337849-tyabf12r 247 5 severe severe JJ cord-337849-tyabf12r 247 6 viral viral JJ cord-337849-tyabf12r 247 7 obstructive obstructive JJ cord-337849-tyabf12r 247 8 bronchitis bronchitis NN cord-337849-tyabf12r 247 9 in in IN cord-337849-tyabf12r 247 10 children child NNS cord-337849-tyabf12r 247 11 Efficacy Efficacy NNP cord-337849-tyabf12r 247 12 and and CC cord-337849-tyabf12r 247 13 effectiveness effectiveness NN cord-337849-tyabf12r 247 14 of of IN cord-337849-tyabf12r 247 15 influenza influenza NN cord-337849-tyabf12r 247 16 vaccines vaccine NNS cord-337849-tyabf12r 247 17 : : : cord-337849-tyabf12r 248 1 A a DT cord-337849-tyabf12r 248 2 systemic systemic JJ cord-337849-tyabf12r 248 3 review review NN cord-337849-tyabf12r 248 4 and and CC cord-337849-tyabf12r 248 5 meta meta NNP cord-337849-tyabf12r 248 6 - - HYPH cord-337849-tyabf12r 248 7 analysis analysis NN cord-337849-tyabf12r 248 8 Antivirals antiviral NNS cord-337849-tyabf12r 248 9 for for IN cord-337849-tyabf12r 248 10 treatment treatment NN cord-337849-tyabf12r 248 11 of of IN cord-337849-tyabf12r 248 12 influenza influenza NN cord-337849-tyabf12r 248 13 : : : cord-337849-tyabf12r 248 14 A a DT cord-337849-tyabf12r 248 15 systematic systematic JJ cord-337849-tyabf12r 248 16 review review NN cord-337849-tyabf12r 248 17 and and CC cord-337849-tyabf12r 248 18 metaanalysis metaanalysis NN cord-337849-tyabf12r 248 19 of of IN cord-337849-tyabf12r 248 20 observational observational JJ cord-337849-tyabf12r 248 21 studies study NNS cord-337849-tyabf12r 249 1 Oseltamivir Oseltamivir NNP cord-337849-tyabf12r 249 2 treatment treatment NN cord-337849-tyabf12r 249 3 for for IN cord-337849-tyabf12r 249 4 influenza influenza NN cord-337849-tyabf12r 249 5 in in IN cord-337849-tyabf12r 249 6 adults adult NNS cord-337849-tyabf12r 249 7 : : : cord-337849-tyabf12r 250 1 A a DT cord-337849-tyabf12r 250 2 meta meta JJ cord-337849-tyabf12r 250 3 - - HYPH cord-337849-tyabf12r 250 4 analysis analysis NN cord-337849-tyabf12r 250 5 of of IN cord-337849-tyabf12r 250 6 randomised randomised JJ cord-337849-tyabf12r 250 7 controlled control VBN cord-337849-tyabf12r 250 8 trials trial NNS cord-337849-tyabf12r 250 9 Oseltamivir Oseltamivir NNP cord-337849-tyabf12r 250 10 for for IN cord-337849-tyabf12r 250 11 influenza influenza NN cord-337849-tyabf12r 250 12 in in IN cord-337849-tyabf12r 250 13 adults adult NNS cord-337849-tyabf12r 250 14 and and CC cord-337849-tyabf12r 250 15 children child NNS cord-337849-tyabf12r 250 16 : : : cord-337849-tyabf12r 251 1 Systematic systematic JJ cord-337849-tyabf12r 251 2 review review NN cord-337849-tyabf12r 251 3 of of IN cord-337849-tyabf12r 251 4 clinical clinical JJ cord-337849-tyabf12r 251 5 study study NN cord-337849-tyabf12r 251 6 reports report NNS cord-337849-tyabf12r 251 7 and and CC cord-337849-tyabf12r 251 8 summary summary NN cord-337849-tyabf12r 251 9 of of IN cord-337849-tyabf12r 251 10 regulatory regulatory JJ cord-337849-tyabf12r 251 11 comments comment NNS cord-337849-tyabf12r 251 12 Addressing address VBG cord-337849-tyabf12r 251 13 the the DT cord-337849-tyabf12r 251 14 public public JJ cord-337849-tyabf12r 251 15 health health NN cord-337849-tyabf12r 251 16 burden burden NN cord-337849-tyabf12r 251 17 of of IN cord-337849-tyabf12r 251 18 respiratory respiratory JJ cord-337849-tyabf12r 251 19 viruses virus NNS cord-337849-tyabf12r 251 20 : : : cord-337849-tyabf12r 252 1 The the DT cord-337849-tyabf12r 252 2 Battle Battle NNP cord-337849-tyabf12r 252 3 against against IN cord-337849-tyabf12r 252 4 Respiratory respiratory JJ cord-337849-tyabf12r 252 5 Viruses virus NNS cord-337849-tyabf12r 252 6 ( ( -LRB- cord-337849-tyabf12r 252 7 BRaVe BRaVe NFP cord-337849-tyabf12r 252 8 ) ) -RRB- cord-337849-tyabf12r 252 9 Initiative initiative NN cord-337849-tyabf12r 252 10 Vitamin vitamin NN cord-337849-tyabf12r 252 11 D d NN cord-337849-tyabf12r 252 12 : : : cord-337849-tyabf12r 252 13 Modulator modulator NN cord-337849-tyabf12r 252 14 of of IN cord-337849-tyabf12r 252 15 the the DT cord-337849-tyabf12r 252 16 immune immune JJ cord-337849-tyabf12r 252 17 system system NN cord-337849-tyabf12r 252 18 Vitamin vitamin NN cord-337849-tyabf12r 252 19 D d NN cord-337849-tyabf12r 252 20 and and CC cord-337849-tyabf12r 252 21 Innate Innate NNP cord-337849-tyabf12r 252 22 and and CC cord-337849-tyabf12r 252 23 Adaptive Adaptive NNP cord-337849-tyabf12r 252 24 Immunity Immunity NNP cord-337849-tyabf12r 252 25 Vitamin vitamin NN cord-337849-tyabf12r 252 26 D d NN cord-337849-tyabf12r 252 27 in in IN cord-337849-tyabf12r 252 28 the the DT cord-337849-tyabf12r 252 29 prevention prevention NN cord-337849-tyabf12r 252 30 of of IN cord-337849-tyabf12r 252 31 acute acute JJ cord-337849-tyabf12r 252 32 respiratory respiratory JJ cord-337849-tyabf12r 252 33 infection infection NN cord-337849-tyabf12r 252 34 : : : cord-337849-tyabf12r 252 35 Systematic systematic JJ cord-337849-tyabf12r 252 36 review review NN cord-337849-tyabf12r 252 37 of of IN cord-337849-tyabf12r 252 38 clinical clinical JJ cord-337849-tyabf12r 252 39 studies study NNS cord-337849-tyabf12r 252 40 A a DT cord-337849-tyabf12r 252 41 randomized randomized JJ cord-337849-tyabf12r 252 42 controlled control VBN cord-337849-tyabf12r 252 43 trial trial NN cord-337849-tyabf12r 252 44 of of IN cord-337849-tyabf12r 252 45 vitamin vitamin NN cord-337849-tyabf12r 252 46 D3 D3 NNP cord-337849-tyabf12r 252 47 supplementation supplementation NN cord-337849-tyabf12r 252 48 in in IN cord-337849-tyabf12r 252 49 African african JJ cord-337849-tyabf12r 252 50 American american JJ cord-337849-tyabf12r 252 51 women woman NNS cord-337849-tyabf12r 252 52 Re re VBP cord-337849-tyabf12r 252 53 : : : cord-337849-tyabf12r 252 54 Epidemic epidemic NN cord-337849-tyabf12r 252 55 influenza influenza NN cord-337849-tyabf12r 252 56 and and CC cord-337849-tyabf12r 252 57 vitamin vitamin NN cord-337849-tyabf12r 252 58 D d NN cord-337849-tyabf12r 252 59 Vitamin vitamin NN cord-337849-tyabf12r 252 60 D d NN cord-337849-tyabf12r 252 61 supplementation supplementation NN cord-337849-tyabf12r 252 62 for for IN cord-337849-tyabf12r 252 63 the the DT cord-337849-tyabf12r 252 64 prevention prevention NN cord-337849-tyabf12r 252 65 of of IN cord-337849-tyabf12r 252 66 acute acute JJ cord-337849-tyabf12r 252 67 respiratory respiratory JJ cord-337849-tyabf12r 252 68 tract tract NN cord-337849-tyabf12r 252 69 infection infection NN cord-337849-tyabf12r 252 70 : : : cord-337849-tyabf12r 252 71 A a DT cord-337849-tyabf12r 252 72 randomized randomized JJ cord-337849-tyabf12r 252 73 , , , cord-337849-tyabf12r 252 74 double double JJ cord-337849-tyabf12r 252 75 - - HYPH cord-337849-tyabf12r 252 76 blinded blinded JJ cord-337849-tyabf12r 252 77 trial trial NN cord-337849-tyabf12r 252 78 among among IN cord-337849-tyabf12r 252 79 young young JJ cord-337849-tyabf12r 252 80 Finnish finnish JJ cord-337849-tyabf12r 252 81 men man NNS cord-337849-tyabf12r 252 82 Randomized randomized JJ cord-337849-tyabf12r 252 83 trial trial NN cord-337849-tyabf12r 252 84 of of IN cord-337849-tyabf12r 252 85 vitamin vitamin NN cord-337849-tyabf12r 252 86 D d NN cord-337849-tyabf12r 252 87 supplementation supplementation NN cord-337849-tyabf12r 252 88 to to TO cord-337849-tyabf12r 252 89 prevent prevent VB cord-337849-tyabf12r 252 90 seasonal seasonal JJ cord-337849-tyabf12r 252 91 influenza influenza NN cord-337849-tyabf12r 252 92 A a NN cord-337849-tyabf12r 252 93 in in IN cord-337849-tyabf12r 252 94 schoolchildren schoolchildren NNS cord-337849-tyabf12r 252 95 Randomized randomized JJ cord-337849-tyabf12r 252 96 trial trial NN cord-337849-tyabf12r 252 97 of of IN cord-337849-tyabf12r 252 98 vitamin vitamin NN cord-337849-tyabf12r 252 99 D d NN cord-337849-tyabf12r 252 100 supplementation supplementation NN cord-337849-tyabf12r 252 101 and and CC cord-337849-tyabf12r 252 102 risk risk NN cord-337849-tyabf12r 252 103 of of IN cord-337849-tyabf12r 252 104 acute acute JJ cord-337849-tyabf12r 252 105 respiratory respiratory JJ cord-337849-tyabf12r 252 106 infection infection NN cord-337849-tyabf12r 252 107 in in IN cord-337849-tyabf12r 252 108 Mongolia Mongolia NNP cord-337849-tyabf12r 252 109 Stelmach Stelmach NNP cord-337849-tyabf12r 252 110 , , , cord-337849-tyabf12r 252 111 I. i. NN cord-337849-tyabf12r 252 112 Vitamin vitamin NN cord-337849-tyabf12r 252 113 D d NN cord-337849-tyabf12r 252 114 supplementation supplementation NN cord-337849-tyabf12r 252 115 in in IN cord-337849-tyabf12r 252 116 children child NNS cord-337849-tyabf12r 252 117 may may MD cord-337849-tyabf12r 252 118 prevent prevent VB cord-337849-tyabf12r 252 119 asthma asthma NN cord-337849-tyabf12r 252 120 exacerbation exacerbation NN cord-337849-tyabf12r 252 121 triggered trigger VBN cord-337849-tyabf12r 252 122 by by IN cord-337849-tyabf12r 252 123 acute acute JJ cord-337849-tyabf12r 252 124 respiratory respiratory JJ cord-337849-tyabf12r 252 125 infection infection NN cord-337849-tyabf12r 253 1 A a DT cord-337849-tyabf12r 253 2 randomized randomized JJ cord-337849-tyabf12r 253 3 controlled control VBN cord-337849-tyabf12r 253 4 trial trial NN cord-337849-tyabf12r 253 5 of of IN cord-337849-tyabf12r 253 6 vitamin vitamin NN cord-337849-tyabf12r 253 7 D3 D3 NNP cord-337849-tyabf12r 253 8 supplementation supplementation NN cord-337849-tyabf12r 253 9 for for IN cord-337849-tyabf12r 253 10 the the DT cord-337849-tyabf12r 253 11 prevention prevention NN cord-337849-tyabf12r 253 12 of of IN cord-337849-tyabf12r 253 13 symptomatic symptomatic JJ cord-337849-tyabf12r 253 14 upper upper JJ cord-337849-tyabf12r 253 15 respiratory respiratory JJ cord-337849-tyabf12r 253 16 tract tract NN cord-337849-tyabf12r 253 17 infections infection NNS cord-337849-tyabf12r 253 18 Effect effect NN cord-337849-tyabf12r 253 19 of of IN cord-337849-tyabf12r 253 20 vitamin vitamin NN cord-337849-tyabf12r 253 21 D3 D3 NNP cord-337849-tyabf12r 253 22 supplementation supplementation NN cord-337849-tyabf12r 253 23 on on IN cord-337849-tyabf12r 253 24 upper upper JJ cord-337849-tyabf12r 253 25 respiratory respiratory JJ cord-337849-tyabf12r 253 26 tract tract NN cord-337849-tyabf12r 253 27 infections infection NNS cord-337849-tyabf12r 253 28 in in IN cord-337849-tyabf12r 253 29 healthy healthy JJ cord-337849-tyabf12r 253 30 adults adult NNS cord-337849-tyabf12r 253 31 : : : cord-337849-tyabf12r 253 32 The the DT cord-337849-tyabf12r 253 33 VIDARIS VIDARIS NNP cord-337849-tyabf12r 253 34 randomized randomize VBD cord-337849-tyabf12r 253 35 controlled control VBN cord-337849-tyabf12r 253 36 trial trial NN cord-337849-tyabf12r 253 37 Effect effect NN cord-337849-tyabf12r 253 38 of of IN cord-337849-tyabf12r 253 39 weekly weekly JJ cord-337849-tyabf12r 253 40 vitamin vitamin NN cord-337849-tyabf12r 253 41 D d NN cord-337849-tyabf12r 253 42 supplements supplement NNS cord-337849-tyabf12r 253 43 on on IN cord-337849-tyabf12r 253 44 mortality mortality NN cord-337849-tyabf12r 253 45 , , , cord-337849-tyabf12r 253 46 morbidity morbidity NN cord-337849-tyabf12r 253 47 , , , cord-337849-tyabf12r 253 48 and and CC cord-337849-tyabf12r 253 49 growth growth NN cord-337849-tyabf12r 253 50 of of IN cord-337849-tyabf12r 253 51 low low JJ cord-337849-tyabf12r 253 52 birthweight birthweight JJ cord-337849-tyabf12r 253 53 term term NN cord-337849-tyabf12r 253 54 infants infant NNS cord-337849-tyabf12r 253 55 in in IN cord-337849-tyabf12r 253 56 India India NNP cord-337849-tyabf12r 253 57 up up RB cord-337849-tyabf12r 253 58 to to IN cord-337849-tyabf12r 253 59 age age NN cord-337849-tyabf12r 253 60 6 6 CD cord-337849-tyabf12r 253 61 months month NNS cord-337849-tyabf12r 253 62 : : : cord-337849-tyabf12r 253 63 Randomised randomised JJ cord-337849-tyabf12r 253 64 controlled control VBN cord-337849-tyabf12r 253 65 trial trial NN cord-337849-tyabf12r 253 66 Effect effect NN cord-337849-tyabf12r 253 67 on on IN cord-337849-tyabf12r 253 68 the the DT cord-337849-tyabf12r 253 69 incidence incidence NN cord-337849-tyabf12r 253 70 of of IN cord-337849-tyabf12r 253 71 pneumonia pneumonia NN cord-337849-tyabf12r 253 72 of of IN cord-337849-tyabf12r 253 73 vitamin vitamin NN cord-337849-tyabf12r 253 74 D d NN cord-337849-tyabf12r 253 75 supplementation supplementation NN cord-337849-tyabf12r 253 76 by by IN cord-337849-tyabf12r 253 77 quarterly quarterly JJ cord-337849-tyabf12r 253 78 bolus bolus NN cord-337849-tyabf12r 253 79 dose dose NN cord-337849-tyabf12r 253 80 to to IN cord-337849-tyabf12r 253 81 infants infant NNS cord-337849-tyabf12r 253 82 in in IN cord-337849-tyabf12r 253 83 Kabul Kabul NNP cord-337849-tyabf12r 253 84 : : : cord-337849-tyabf12r 254 1 A a DT cord-337849-tyabf12r 254 2 randomised randomised JJ cord-337849-tyabf12r 254 3 controlled control VBN cord-337849-tyabf12r 254 4 superiority superiority NN cord-337849-tyabf12r 254 5 trial trial NN cord-337849-tyabf12r 254 6 Vitamin vitamin NN cord-337849-tyabf12r 254 7 D d NN cord-337849-tyabf12r 254 8 supplementation supplementation NN cord-337849-tyabf12r 254 9 did do VBD cord-337849-tyabf12r 254 10 not not RB cord-337849-tyabf12r 254 11 prevent prevent VB cord-337849-tyabf12r 254 12 influenza influenza NN cord-337849-tyabf12r 254 13 - - HYPH cord-337849-tyabf12r 254 14 like like JJ cord-337849-tyabf12r 254 15 illness illness NN cord-337849-tyabf12r 254 16 as as IN cord-337849-tyabf12r 254 17 diagnosed diagnose VBN cord-337849-tyabf12r 254 18 retrospectively retrospectively RB cord-337849-tyabf12r 254 19 by by IN cord-337849-tyabf12r 254 20 questionnaires questionnaire NNS cord-337849-tyabf12r 254 21 in in IN cord-337849-tyabf12r 254 22 subjects subject NNS cord-337849-tyabf12r 254 23 participating participate VBG cord-337849-tyabf12r 254 24 in in IN cord-337849-tyabf12r 254 25 randomized randomized JJ cord-337849-tyabf12r 254 26 clinical clinical JJ cord-337849-tyabf12r 254 27 trials trial NNS cord-337849-tyabf12r 254 28 . . . cord-337849-tyabf12r 255 1 Scand Scand NNP cord-337849-tyabf12r 255 2 Effect Effect NNP cord-337849-tyabf12r 255 3 of of IN cord-337849-tyabf12r 255 4 vitamin vitamin NN cord-337849-tyabf12r 255 5 D3 D3 NNP cord-337849-tyabf12r 255 6 on on IN cord-337849-tyabf12r 255 7 asthma asthma NN cord-337849-tyabf12r 255 8 treatment treatment NN cord-337849-tyabf12r 255 9 failures failure NNS cord-337849-tyabf12r 255 10 in in IN cord-337849-tyabf12r 255 11 adults adult NNS cord-337849-tyabf12r 255 12 with with IN cord-337849-tyabf12r 255 13 symptomatic symptomatic JJ cord-337849-tyabf12r 255 14 asthma asthma NN cord-337849-tyabf12r 255 15 and and CC cord-337849-tyabf12r 255 16 lower low JJR cord-337849-tyabf12r 255 17 vitamin vitamin NN cord-337849-tyabf12r 255 18 D d NN cord-337849-tyabf12r 255 19 levels level NNS cord-337849-tyabf12r 255 20 : : : cord-337849-tyabf12r 255 21 The the DT cord-337849-tyabf12r 255 22 VIDI VIDI NNP cord-337849-tyabf12r 255 23 randomized randomize VBD cord-337849-tyabf12r 255 24 clinical clinical JJ cord-337849-tyabf12r 255 25 trial trial NN cord-337849-tyabf12r 255 26 Double double JJ cord-337849-tyabf12r 255 27 - - HYPH cord-337849-tyabf12r 255 28 blind blind JJ cord-337849-tyabf12r 255 29 randomised randomised JJ cord-337849-tyabf12r 255 30 placebo placebo NN cord-337849-tyabf12r 255 31 - - HYPH cord-337849-tyabf12r 255 32 controlled control VBN cord-337849-tyabf12r 255 33 trial trial NN cord-337849-tyabf12r 255 34 of of IN cord-337849-tyabf12r 255 35 bolus bolus NN cord-337849-tyabf12r 255 36 - - HYPH cord-337849-tyabf12r 255 37 dose dose NN cord-337849-tyabf12r 255 38 vitamin vitamin NN cord-337849-tyabf12r 255 39 D3 D3 NNP cord-337849-tyabf12r 255 40 supplementation supplementation NN cord-337849-tyabf12r 255 41 in in IN cord-337849-tyabf12r 255 42 adults adult NNS cord-337849-tyabf12r 255 43 with with IN cord-337849-tyabf12r 255 44 asthma asthma NN cord-337849-tyabf12r 255 45 ( ( -LRB- cord-337849-tyabf12r 255 46 ViDiAs vidias UH cord-337849-tyabf12r 255 47 ) ) -RRB- cord-337849-tyabf12r 256 1 Vitamin vitamin NN cord-337849-tyabf12r 256 2 D3 D3 NNP cord-337849-tyabf12r 256 3 supplementation supplementation NN cord-337849-tyabf12r 256 4 in in IN cord-337849-tyabf12r 256 5 patients patient NNS cord-337849-tyabf12r 256 6 with with IN cord-337849-tyabf12r 256 7 chronic chronic JJ cord-337849-tyabf12r 256 8 obstructive obstructive JJ cord-337849-tyabf12r 256 9 pulmonary pulmonary JJ cord-337849-tyabf12r 256 10 disease disease NN cord-337849-tyabf12r 256 11 ( ( -LRB- cord-337849-tyabf12r 256 12 ViDiCO ViDiCO NNP cord-337849-tyabf12r 256 13 ) ) -RRB- cord-337849-tyabf12r 256 14 : : : cord-337849-tyabf12r 257 1 A a DT cord-337849-tyabf12r 257 2 multicentre multicentre NN cord-337849-tyabf12r 257 3 , , , cord-337849-tyabf12r 257 4 double double JJ cord-337849-tyabf12r 257 5 - - HYPH cord-337849-tyabf12r 257 6 blind blind JJ cord-337849-tyabf12r 257 7 , , , cord-337849-tyabf12r 257 8 randomised randomised JJ cord-337849-tyabf12r 257 9 controlled control VBN cord-337849-tyabf12r 257 10 trial trial NN cord-337849-tyabf12r 257 11 Vitamin vitamin NN cord-337849-tyabf12r 257 12 D d NN cord-337849-tyabf12r 257 13 and and CC cord-337849-tyabf12r 257 14 respiratory respiratory JJ cord-337849-tyabf12r 257 15 tract tract NN cord-337849-tyabf12r 257 16 infections infection NNS cord-337849-tyabf12r 257 17 : : : cord-337849-tyabf12r 257 18 A a DT cord-337849-tyabf12r 257 19 systematic systematic JJ cord-337849-tyabf12r 257 20 review review NN cord-337849-tyabf12r 257 21 and and CC cord-337849-tyabf12r 257 22 meta meta NNP cord-337849-tyabf12r 257 23 - - HYPH cord-337849-tyabf12r 257 24 analysis analysis NN cord-337849-tyabf12r 257 25 of of IN cord-337849-tyabf12r 257 26 randomized randomized JJ cord-337849-tyabf12r 257 27 controlled control VBN cord-337849-tyabf12r 257 28 trials trial NNS cord-337849-tyabf12r 257 29 Activation Activation NNP cord-337849-tyabf12r 257 30 of of IN cord-337849-tyabf12r 257 31 airway airway NN cord-337849-tyabf12r 257 32 epithelial epithelial JJ cord-337849-tyabf12r 257 33 cells cell NNS cord-337849-tyabf12r 257 34 by by IN cord-337849-tyabf12r 257 35 toll toll NN cord-337849-tyabf12r 257 36 - - HYPH cord-337849-tyabf12r 257 37 like like JJ cord-337849-tyabf12r 257 38 receptor receptor NN cord-337849-tyabf12r 257 39 agonists agonist NNS cord-337849-tyabf12r 257 40 Regulation regulation NN cord-337849-tyabf12r 257 41 of of IN cord-337849-tyabf12r 257 42 immunological immunological JJ cord-337849-tyabf12r 257 43 homeostasis homeostasis NN cord-337849-tyabf12r 257 44 in in IN cord-337849-tyabf12r 257 45 the the DT cord-337849-tyabf12r 257 46 respiratory respiratory JJ cord-337849-tyabf12r 257 47 tract tract NN cord-337849-tyabf12r 257 48 Viral viral JJ cord-337849-tyabf12r 257 49 activation activation NN cord-337849-tyabf12r 257 50 of of IN cord-337849-tyabf12r 257 51 macrophages macrophage NNS cord-337849-tyabf12r 257 52 through through IN cord-337849-tyabf12r 257 53 TLR tlr NN cord-337849-tyabf12r 257 54 - - HYPH cord-337849-tyabf12r 257 55 dependent dependent JJ cord-337849-tyabf12r 257 56 and and CC cord-337849-tyabf12r 257 57 -independent -independent JJ cord-337849-tyabf12r 257 58 pathways pathway NNS cord-337849-tyabf12r 257 59 Pattern Pattern NNP cord-337849-tyabf12r 257 60 recognition recognition NN cord-337849-tyabf12r 257 61 receptors receptor NNS cord-337849-tyabf12r 257 62 and and CC cord-337849-tyabf12r 257 63 inflammation inflammation NN cord-337849-tyabf12r 257 64 UNC93B1 unc93b1 NN cord-337849-tyabf12r 257 65 delivers deliver VBZ cord-337849-tyabf12r 257 66 nucleotide nucleotide NN cord-337849-tyabf12r 257 67 - - HYPH cord-337849-tyabf12r 257 68 sensing sense VBG cord-337849-tyabf12r 257 69 toll toll NN cord-337849-tyabf12r 257 70 - - HYPH cord-337849-tyabf12r 257 71 like like JJ cord-337849-tyabf12r 257 72 receptors receptor NNS cord-337849-tyabf12r 257 73 to to TO cord-337849-tyabf12r 257 74 endolysosomes endolysosomes VB cord-337849-tyabf12r 257 75 Recognition Recognition NNP cord-337849-tyabf12r 257 76 of of IN cord-337849-tyabf12r 257 77 single single RB cord-337849-tyabf12r 257 78 - - HYPH cord-337849-tyabf12r 257 79 stranded strand VBN cord-337849-tyabf12r 257 80 RNA RNA NNP cord-337849-tyabf12r 257 81 viruses virus NNS cord-337849-tyabf12r 257 82 by by IN cord-337849-tyabf12r 257 83 Toll toll NN cord-337849-tyabf12r 257 84 - - HYPH cord-337849-tyabf12r 257 85 like like JJ cord-337849-tyabf12r 257 86 receptor receptor NN cord-337849-tyabf12r 257 87 7 7 CD cord-337849-tyabf12r 257 88 Toll Toll NNP cord-337849-tyabf12r 257 89 - - HYPH cord-337849-tyabf12r 257 90 like like JJ cord-337849-tyabf12r 257 91 receptor receptor NN cord-337849-tyabf12r 257 92 9-mediated 9-mediated CD cord-337849-tyabf12r 257 93 recognition recognition NN cord-337849-tyabf12r 257 94 of of IN cord-337849-tyabf12r 257 95 Herpes Herpes NNP cord-337849-tyabf12r 257 96 simplex simplex NNP cord-337849-tyabf12r 257 97 virus-2 virus-2 NNP cord-337849-tyabf12r 257 98 by by IN cord-337849-tyabf12r 257 99 plasmacytoid plasmacytoid NNP cord-337849-tyabf12r 257 100 dendritic dendritic NNP cord-337849-tyabf12r 257 101 cells cell NNS cord-337849-tyabf12r 257 102 Recognition Recognition NNP cord-337849-tyabf12r 257 103 of of IN cord-337849-tyabf12r 257 104 double double RB cord-337849-tyabf12r 257 105 - - HYPH cord-337849-tyabf12r 257 106 stranded strand VBN cord-337849-tyabf12r 257 107 RNA RNA NNP cord-337849-tyabf12r 257 108 and and CC cord-337849-tyabf12r 257 109 activation activation NN cord-337849-tyabf12r 257 110 of of IN cord-337849-tyabf12r 257 111 NF NF NNP cord-337849-tyabf12r 257 112 - - HYPH cord-337849-tyabf12r 257 113 kappaB kappaB NNP cord-337849-tyabf12r 257 114 by by IN cord-337849-tyabf12r 257 115 Toll Toll NNP cord-337849-tyabf12r 257 116 - - HYPH cord-337849-tyabf12r 257 117 like like JJ cord-337849-tyabf12r 257 118 receptor receptor NN cord-337849-tyabf12r 257 119 3 3 CD cord-337849-tyabf12r 257 120 Immunity immunity NN cord-337849-tyabf12r 257 121 to to IN cord-337849-tyabf12r 257 122 respiratory respiratory JJ cord-337849-tyabf12r 257 123 viruses virus NNS cord-337849-tyabf12r 257 124 Pattern pattern NN cord-337849-tyabf12r 257 125 recognition recognition NN cord-337849-tyabf12r 257 126 receptors receptor NNS cord-337849-tyabf12r 257 127 TLR4 TLR4 NNP cord-337849-tyabf12r 257 128 and and CC cord-337849-tyabf12r 257 129 CD14 CD14 NNP cord-337849-tyabf12r 257 130 mediate mediate VBP cord-337849-tyabf12r 257 131 response response NN cord-337849-tyabf12r 257 132 to to IN cord-337849-tyabf12r 258 1 respiratory respiratory JJ cord-337849-tyabf12r 258 2 syncytial syncytial JJ cord-337849-tyabf12r 258 3 virus virus NN cord-337849-tyabf12r 258 4 Intracellular Intracellular NNP cord-337849-tyabf12r 258 5 TLR4-MD-2 TLR4-MD-2 NNP cord-337849-tyabf12r 258 6 in in IN cord-337849-tyabf12r 258 7 macrophages macrophage NNS cord-337849-tyabf12r 258 8 senses sense VBZ cord-337849-tyabf12r 258 9 Gram gram NN cord-337849-tyabf12r 258 10 - - HYPH cord-337849-tyabf12r 258 11 negative negative JJ cord-337849-tyabf12r 258 12 bacteria bacteria NNS cord-337849-tyabf12r 258 13 and and CC cord-337849-tyabf12r 258 14 induces induce VBZ cord-337849-tyabf12r 258 15 a a DT cord-337849-tyabf12r 258 16 unique unique JJ cord-337849-tyabf12r 258 17 set set NN cord-337849-tyabf12r 258 18 of of IN cord-337849-tyabf12r 258 19 LPS LPS NNP cord-337849-tyabf12r 258 20 - - HYPH cord-337849-tyabf12r 258 21 dependent dependent JJ cord-337849-tyabf12r 258 22 genes gene NNS cord-337849-tyabf12r 259 1 Murine murine JJ cord-337849-tyabf12r 259 2 toll toll NN cord-337849-tyabf12r 259 3 - - HYPH cord-337849-tyabf12r 259 4 like like JJ cord-337849-tyabf12r 259 5 receptor receptor NN cord-337849-tyabf12r 259 6 2 2 CD cord-337849-tyabf12r 259 7 activation activation NN cord-337849-tyabf12r 259 8 induces induce VBZ cord-337849-tyabf12r 259 9 type type NN cord-337849-tyabf12r 260 1 I -PRON- PRP cord-337849-tyabf12r 261 1 interferon interferon NN cord-337849-tyabf12r 261 2 responses response NNS cord-337849-tyabf12r 261 3 from from IN cord-337849-tyabf12r 261 4 endolysosomal endolysosomal JJ cord-337849-tyabf12r 261 5 compartments compartment NNS cord-337849-tyabf12r 262 1 Respiratory respiratory JJ cord-337849-tyabf12r 262 2 syncytial syncytial JJ cord-337849-tyabf12r 262 3 virus virus NN cord-337849-tyabf12r 262 4 activates activate VBZ cord-337849-tyabf12r 262 5 innate innate JJ cord-337849-tyabf12r 262 6 immunity immunity NN cord-337849-tyabf12r 262 7 through through IN cord-337849-tyabf12r 262 8 Toll Toll NNP cord-337849-tyabf12r 262 9 - - HYPH cord-337849-tyabf12r 262 10 like like JJ cord-337849-tyabf12r 262 11 receptor receptor NN cord-337849-tyabf12r 262 12 2 2 CD cord-337849-tyabf12r 262 13 Reis Reis NNP cord-337849-tyabf12r 262 14 e e NN cord-337849-tyabf12r 262 15 Sousa Sousa NNP cord-337849-tyabf12r 262 16 , , , cord-337849-tyabf12r 262 17 C. C. NNP cord-337849-tyabf12r 262 18 RIG RIG NNP cord-337849-tyabf12r 262 19 - - HYPH cord-337849-tyabf12r 262 20 I -PRON- PRP cord-337849-tyabf12r 262 21 - - HYPH cord-337849-tyabf12r 262 22 mediated mediate VBN cord-337849-tyabf12r 262 23 antiviral antiviral JJ cord-337849-tyabf12r 262 24 responses response NNS cord-337849-tyabf12r 262 25 to to IN cord-337849-tyabf12r 262 26 single single RB cord-337849-tyabf12r 262 27 - - HYPH cord-337849-tyabf12r 262 28 stranded strand VBN cord-337849-tyabf12r 262 29 RNA RNA NNP cord-337849-tyabf12r 262 30 bearing bear VBG cord-337849-tyabf12r 262 31 5′-phosphates 5′-phosphates CD cord-337849-tyabf12r 262 32 MDA5 MDA5 NNP cord-337849-tyabf12r 262 33 detects detect VBZ cord-337849-tyabf12r 262 34 the the DT cord-337849-tyabf12r 262 35 double double RB cord-337849-tyabf12r 262 36 - - HYPH cord-337849-tyabf12r 262 37 stranded strand VBN cord-337849-tyabf12r 262 38 RNA RNA NNP cord-337849-tyabf12r 262 39 replicative replicative JJ cord-337849-tyabf12r 262 40 form form NN cord-337849-tyabf12r 262 41 in in IN cord-337849-tyabf12r 262 42 picornavirus picornavirus NN cord-337849-tyabf12r 262 43 - - HYPH cord-337849-tyabf12r 262 44 infected infect VBN cord-337849-tyabf12r 262 45 cells cell NNS cord-337849-tyabf12r 262 46 Activation activation NN cord-337849-tyabf12r 262 47 of of IN cord-337849-tyabf12r 262 48 innate innate JJ cord-337849-tyabf12r 262 49 immune immune JJ cord-337849-tyabf12r 262 50 antiviral antiviral JJ cord-337849-tyabf12r 262 51 responses response NNS cord-337849-tyabf12r 262 52 by by IN cord-337849-tyabf12r 262 53 Nod2 Nod2 NNP cord-337849-tyabf12r 262 54 Distinct Distinct NNP cord-337849-tyabf12r 262 55 RIG RIG NNP cord-337849-tyabf12r 262 56 - - : cord-337849-tyabf12r 262 57 I I NNP cord-337849-tyabf12r 262 58 and and CC cord-337849-tyabf12r 262 59 MDA5 MDA5 NNP cord-337849-tyabf12r 262 60 signaling signal VBG cord-337849-tyabf12r 262 61 by by IN cord-337849-tyabf12r 262 62 RNA RNA NNP cord-337849-tyabf12r 262 63 viruses virus NNS cord-337849-tyabf12r 262 64 in in IN cord-337849-tyabf12r 262 65 innate innate JJ cord-337849-tyabf12r 262 66 immunity immunity NN cord-337849-tyabf12r 262 67 Viral viral JJ cord-337849-tyabf12r 262 68 evasion evasion NN cord-337849-tyabf12r 262 69 and and CC cord-337849-tyabf12r 262 70 subversion subversion NN cord-337849-tyabf12r 262 71 of of IN cord-337849-tyabf12r 262 72 pattern pattern NN cord-337849-tyabf12r 262 73 - - HYPH cord-337849-tyabf12r 262 74 recognition recognition NN cord-337849-tyabf12r 262 75 receptor receptor NN cord-337849-tyabf12r 262 76 signalling signal VBG cord-337849-tyabf12r 262 77 Signaling signal VBG cord-337849-tyabf12r 262 78 in in IN cord-337849-tyabf12r 262 79 innate innate JJ cord-337849-tyabf12r 262 80 immunity immunity NN cord-337849-tyabf12r 262 81 and and CC cord-337849-tyabf12r 262 82 inflammation inflammation NN cord-337849-tyabf12r 262 83 Neutrophil Neutrophil NNP cord-337849-tyabf12r 262 84 recruitment recruitment NN cord-337849-tyabf12r 262 85 , , , cord-337849-tyabf12r 262 86 chemokine chemokine NN cord-337849-tyabf12r 262 87 receptors receptor NNS cord-337849-tyabf12r 262 88 , , , cord-337849-tyabf12r 262 89 and and CC cord-337849-tyabf12r 262 90 resistance resistance NN cord-337849-tyabf12r 262 91 to to IN cord-337849-tyabf12r 262 92 mucosal mucosal JJ cord-337849-tyabf12r 262 93 infection infection NN cord-337849-tyabf12r 262 94 IL-15 IL-15 NNP cord-337849-tyabf12r 262 95 participates participate VBZ cord-337849-tyabf12r 262 96 in in IN cord-337849-tyabf12r 262 97 the the DT cord-337849-tyabf12r 262 98 respiratory respiratory JJ cord-337849-tyabf12r 262 99 innate innate JJ cord-337849-tyabf12r 262 100 immune immune JJ cord-337849-tyabf12r 262 101 response response NN cord-337849-tyabf12r 262 102 to to IN cord-337849-tyabf12r 262 103 influenza influenza NN cord-337849-tyabf12r 262 104 virus virus NN cord-337849-tyabf12r 262 105 infection infection NN cord-337849-tyabf12r 262 106 CXCR2 CXCR2 NNP cord-337849-tyabf12r 262 107 is be VBZ cord-337849-tyabf12r 262 108 required require VBN cord-337849-tyabf12r 262 109 for for IN cord-337849-tyabf12r 262 110 neutrophil neutrophil NN cord-337849-tyabf12r 262 111 recruitment recruitment NN cord-337849-tyabf12r 262 112 to to IN cord-337849-tyabf12r 262 113 the the DT cord-337849-tyabf12r 262 114 lung lung NN cord-337849-tyabf12r 262 115 during during IN cord-337849-tyabf12r 262 116 influenza influenza NN cord-337849-tyabf12r 262 117 virus virus NN cord-337849-tyabf12r 262 118 infection infection NN cord-337849-tyabf12r 262 119 , , , cord-337849-tyabf12r 262 120 but but CC cord-337849-tyabf12r 262 121 is be VBZ cord-337849-tyabf12r 262 122 not not RB cord-337849-tyabf12r 262 123 essential essential JJ cord-337849-tyabf12r 262 124 for for IN cord-337849-tyabf12r 262 125 viral viral JJ cord-337849-tyabf12r 262 126 clearance clearance NN cord-337849-tyabf12r 262 127 CD11c+ CD11c+ NNP cord-337849-tyabf12r 262 128 antigen antigen NN cord-337849-tyabf12r 262 129 presenting present VBG cord-337849-tyabf12r 262 130 cells cell NNS cord-337849-tyabf12r 262 131 from from IN cord-337849-tyabf12r 262 132 the the DT cord-337849-tyabf12r 262 133 alveolar alveolar JJ cord-337849-tyabf12r 262 134 space space NN cord-337849-tyabf12r 262 135 , , , cord-337849-tyabf12r 262 136 lung lung NN cord-337849-tyabf12r 262 137 parenchyma parenchyma NN cord-337849-tyabf12r 262 138 and and CC cord-337849-tyabf12r 262 139 spleen spleen NNS cord-337849-tyabf12r 262 140 differ differ VBP cord-337849-tyabf12r 262 141 in in IN cord-337849-tyabf12r 262 142 their -PRON- PRP$ cord-337849-tyabf12r 262 143 phenotype phenotype NN cord-337849-tyabf12r 262 144 and and CC cord-337849-tyabf12r 262 145 capabilities capability NNS cord-337849-tyabf12r 262 146 to to TO cord-337849-tyabf12r 262 147 activate activate VB cord-337849-tyabf12r 262 148 naive naive JJ cord-337849-tyabf12r 262 149 and and CC cord-337849-tyabf12r 262 150 antigen antigen NN cord-337849-tyabf12r 262 151 - - HYPH cord-337849-tyabf12r 262 152 primed prime VBN cord-337849-tyabf12r 262 153 T t NN cord-337849-tyabf12r 262 154 cells cell NNS cord-337849-tyabf12r 262 155 Macrophage macrophage NN cord-337849-tyabf12r 262 156 defences defence NNS cord-337849-tyabf12r 262 157 against against IN cord-337849-tyabf12r 262 158 respiratory respiratory JJ cord-337849-tyabf12r 262 159 tract tract NN cord-337849-tyabf12r 262 160 infections infection NNS cord-337849-tyabf12r 262 161 Cationic Cationic NNP cord-337849-tyabf12r 262 162 host host NN cord-337849-tyabf12r 262 163 defence defence NN cord-337849-tyabf12r 262 164 peptides peptide NNS cord-337849-tyabf12r 262 165 : : : cord-337849-tyabf12r 262 166 Potential potential JJ cord-337849-tyabf12r 262 167 as as IN cord-337849-tyabf12r 262 168 antiviral antiviral JJ cord-337849-tyabf12r 262 169 therapeutics therapeutic NNS cord-337849-tyabf12r 262 170 Antiviral antiviral JJ cord-337849-tyabf12r 262 171 activity activity NN cord-337849-tyabf12r 262 172 and and CC cord-337849-tyabf12r 262 173 increased increase VBN cord-337849-tyabf12r 262 174 host host NN cord-337849-tyabf12r 262 175 defense defense NN cord-337849-tyabf12r 262 176 against against IN cord-337849-tyabf12r 262 177 influenza influenza NN cord-337849-tyabf12r 262 178 infection infection NN cord-337849-tyabf12r 262 179 elicited elicit VBN cord-337849-tyabf12r 262 180 by by IN cord-337849-tyabf12r 262 181 the the DT cord-337849-tyabf12r 262 182 human human JJ cord-337849-tyabf12r 262 183 cathelicidin cathelicidin NN cord-337849-tyabf12r 262 184 LL-37 LL-37 NNP cord-337849-tyabf12r 262 185 LL37 LL37 NNP cord-337849-tyabf12r 262 186 and and CC cord-337849-tyabf12r 262 187 cationic cationic JJ cord-337849-tyabf12r 262 188 peptides peptide NNS cord-337849-tyabf12r 262 189 enhance enhance VBP cord-337849-tyabf12r 262 190 TLR3 TLR3 NNP cord-337849-tyabf12r 262 191 signaling signal VBG cord-337849-tyabf12r 262 192 by by IN cord-337849-tyabf12r 262 193 viral viral JJ cord-337849-tyabf12r 262 194 double double RB cord-337849-tyabf12r 262 195 - - HYPH cord-337849-tyabf12r 262 196 stranded stranded JJ cord-337849-tyabf12r 262 197 RNAs rna NNS cord-337849-tyabf12r 263 1 The the DT cord-337849-tyabf12r 263 2 human human NN cord-337849-tyabf12r 263 3 cathelicidin cathelicidin NN cord-337849-tyabf12r 263 4 LL-37 LL-37 NNP cord-337849-tyabf12r 263 5 has have VBZ cord-337849-tyabf12r 263 6 antiviral antiviral JJ cord-337849-tyabf12r 263 7 activity activity NN cord-337849-tyabf12r 263 8 against against IN cord-337849-tyabf12r 263 9 respiratory respiratory JJ cord-337849-tyabf12r 263 10 syncytial syncytial JJ cord-337849-tyabf12r 263 11 virus virus NN cord-337849-tyabf12r 263 12 Macrophage macrophage NN cord-337849-tyabf12r 263 13 impairment impairment NN cord-337849-tyabf12r 263 14 underlies underlie VBZ cord-337849-tyabf12r 263 15 airway airway NN cord-337849-tyabf12r 263 16 occlusion occlusion NN cord-337849-tyabf12r 263 17 in in IN cord-337849-tyabf12r 263 18 primary primary JJ cord-337849-tyabf12r 263 19 respiratory respiratory JJ cord-337849-tyabf12r 263 20 syncytial syncytial JJ cord-337849-tyabf12r 263 21 virus virus NN cord-337849-tyabf12r 263 22 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 264 1 Alveolar alveolar NN cord-337849-tyabf12r 264 2 macrophages macrophage NNS cord-337849-tyabf12r 264 3 are be VBP cord-337849-tyabf12r 264 4 essential essential JJ cord-337849-tyabf12r 264 5 for for IN cord-337849-tyabf12r 264 6 protection protection NN cord-337849-tyabf12r 264 7 from from IN cord-337849-tyabf12r 264 8 respiratory respiratory JJ cord-337849-tyabf12r 264 9 failure failure NN cord-337849-tyabf12r 264 10 and and CC cord-337849-tyabf12r 264 11 associated associate VBN cord-337849-tyabf12r 264 12 morbidity morbidity NN cord-337849-tyabf12r 264 13 following follow VBG cord-337849-tyabf12r 264 14 influenza influenza NN cord-337849-tyabf12r 264 15 virus virus NN cord-337849-tyabf12r 264 16 infection infection NN cord-337849-tyabf12r 264 17 Regulating regulate VBG cord-337849-tyabf12r 264 18 the the DT cord-337849-tyabf12r 264 19 adaptive adaptive JJ cord-337849-tyabf12r 264 20 immune immune JJ cord-337849-tyabf12r 264 21 response response NN cord-337849-tyabf12r 264 22 to to IN cord-337849-tyabf12r 264 23 repiratory repiratory NNP cord-337849-tyabf12r 264 24 virus virus NN cord-337849-tyabf12r 264 25 infection infection NN cord-337849-tyabf12r 265 1 Balancing balance VBG cord-337849-tyabf12r 265 2 immunity immunity NN cord-337849-tyabf12r 265 3 and and CC cord-337849-tyabf12r 265 4 tolerance tolerance NN cord-337849-tyabf12r 265 5 CC cc NN cord-337849-tyabf12r 265 6 chemokine chemokine NN cord-337849-tyabf12r 265 7 ligand ligand NN cord-337849-tyabf12r 265 8 3 3 CD cord-337849-tyabf12r 265 9 ( ( -LRB- cord-337849-tyabf12r 265 10 CCL3 CCL3 NNP cord-337849-tyabf12r 265 11 ) ) -RRB- cord-337849-tyabf12r 265 12 regulates regulate VBZ cord-337849-tyabf12r 265 13 CD8(+)-T cd8(+)-t CD cord-337849-tyabf12r 265 14 - - HYPH cord-337849-tyabf12r 265 15 cells cell NNS cord-337849-tyabf12r 265 16 effector effector NN cord-337849-tyabf12r 265 17 function function NN cord-337849-tyabf12r 265 18 and and CC cord-337849-tyabf12r 265 19 migration migration NN cord-337849-tyabf12r 265 20 following follow VBG cord-337849-tyabf12r 265 21 viral viral JJ cord-337849-tyabf12r 265 22 infection infection NN cord-337849-tyabf12r 265 23 CC cc NN cord-337849-tyabf12r 265 24 chemokine chemokine NN cord-337849-tyabf12r 265 25 receptor receptor NN cord-337849-tyabf12r 265 26 5 5 CD cord-337849-tyabf12r 265 27 and and CC cord-337849-tyabf12r 265 28 CXC CXC NNP cord-337849-tyabf12r 265 29 chemokine chemokine NN cord-337849-tyabf12r 265 30 receptor receptor NN cord-337849-tyabf12r 265 31 6 6 CD cord-337849-tyabf12r 265 32 expression expression NN cord-337849-tyabf12r 265 33 by by IN cord-337849-tyabf12r 265 34 lung lung NN cord-337849-tyabf12r 265 35 CD8 CD8 NNP cord-337849-tyabf12r 265 36 + + CC cord-337849-tyabf12r 266 1 cells cell NNS cord-337849-tyabf12r 266 2 correlates correlate VBZ cord-337849-tyabf12r 266 3 with with IN cord-337849-tyabf12r 266 4 chronic chronic JJ cord-337849-tyabf12r 266 5 obstructive obstructive JJ cord-337849-tyabf12r 266 6 pulmonary pulmonary JJ cord-337849-tyabf12r 266 7 disease disease NN cord-337849-tyabf12r 266 8 severity severity NN cord-337849-tyabf12r 266 9 CXC CXC NNP cord-337849-tyabf12r 266 10 chemokines chemokine NNS cord-337849-tyabf12r 266 11 IP-10 IP-10 NNP cord-337849-tyabf12r 266 12 and and CC cord-337849-tyabf12r 266 13 mig mig NNP cord-337849-tyabf12r 266 14 expression expression NN cord-337849-tyabf12r 266 15 and and CC cord-337849-tyabf12r 266 16 direct direct JJ cord-337849-tyabf12r 266 17 migration migration NN cord-337849-tyabf12r 266 18 of of IN cord-337849-tyabf12r 266 19 pulmonary pulmonary NN cord-337849-tyabf12r 266 20 CD8+/CXCR3 cd8+/cxcr3 NN cord-337849-tyabf12r 267 1 + + CC cord-337849-tyabf12r 268 1 T T NNP cord-337849-tyabf12r 268 2 cells cell NNS cord-337849-tyabf12r 268 3 in in IN cord-337849-tyabf12r 268 4 the the DT cord-337849-tyabf12r 268 5 lungs lung NNS cord-337849-tyabf12r 268 6 of of IN cord-337849-tyabf12r 268 7 patients patient NNS cord-337849-tyabf12r 268 8 with with IN cord-337849-tyabf12r 268 9 HIV HIV NNP cord-337849-tyabf12r 268 10 infection infection NN cord-337849-tyabf12r 268 11 and and CC cord-337849-tyabf12r 268 12 T t NN cord-337849-tyabf12r 268 13 - - HYPH cord-337849-tyabf12r 268 14 cell cell NN cord-337849-tyabf12r 268 15 alveolitis alveolitis NN cord-337849-tyabf12r 269 1 Orchestrating orchestrate VBG cord-337849-tyabf12r 269 2 the the DT cord-337849-tyabf12r 269 3 orchestrators orchestrator NNS cord-337849-tyabf12r 269 4 : : : cord-337849-tyabf12r 269 5 Chemokines Chemokines NNPS cord-337849-tyabf12r 269 6 in in IN cord-337849-tyabf12r 269 7 control control NN cord-337849-tyabf12r 269 8 of of IN cord-337849-tyabf12r 269 9 T T NNP cord-337849-tyabf12r 269 10 cell cell NN cord-337849-tyabf12r 269 11 traffic traffic NN cord-337849-tyabf12r 270 1 The the DT cord-337849-tyabf12r 270 2 role role NN cord-337849-tyabf12r 270 3 of of IN cord-337849-tyabf12r 270 4 the the DT cord-337849-tyabf12r 270 5 antibody antibody NN cord-337849-tyabf12r 270 6 response response NN cord-337849-tyabf12r 270 7 in in IN cord-337849-tyabf12r 270 8 influenza influenza NN cord-337849-tyabf12r 270 9 virus virus NN cord-337849-tyabf12r 270 10 infection infection NN cord-337849-tyabf12r 270 11 Virus virus NN cord-337849-tyabf12r 270 12 - - : cord-337849-tyabf12r 270 13 neutralizing neutralize VBG cord-337849-tyabf12r 270 14 antibodies antibody NNS cord-337849-tyabf12r 270 15 of of IN cord-337849-tyabf12r 270 16 immunoglobulin immunoglobulin NN cord-337849-tyabf12r 270 17 G G NNP cord-337849-tyabf12r 270 18 ( ( -LRB- cord-337849-tyabf12r 270 19 IgG IgG NNP cord-337849-tyabf12r 270 20 ) ) -RRB- cord-337849-tyabf12r 270 21 but but CC cord-337849-tyabf12r 270 22 not not RB cord-337849-tyabf12r 270 23 of of IN cord-337849-tyabf12r 270 24 IgM IgM NNP cord-337849-tyabf12r 270 25 or or CC cord-337849-tyabf12r 270 26 IgA IgA NNP cord-337849-tyabf12r 270 27 isotypes isotypes NNP cord-337849-tyabf12r 270 28 can can MD cord-337849-tyabf12r 270 29 cure cure VB cord-337849-tyabf12r 270 30 influenza influenza NN cord-337849-tyabf12r 270 31 virus virus NN cord-337849-tyabf12r 270 32 pneumonia pneumonia NN cord-337849-tyabf12r 270 33 in in IN cord-337849-tyabf12r 270 34 SCID SCID NNP cord-337849-tyabf12r 270 35 mice mouse NNS cord-337849-tyabf12r 270 36 Antibody Antibody NNP cord-337849-tyabf12r 270 37 - - HYPH cord-337849-tyabf12r 270 38 dependent dependent JJ cord-337849-tyabf12r 270 39 cellular cellular JJ cord-337849-tyabf12r 270 40 cytotoxicity cytotoxicity NN cord-337849-tyabf12r 270 41 is be VBZ cord-337849-tyabf12r 270 42 associated associate VBN cord-337849-tyabf12r 270 43 with with IN cord-337849-tyabf12r 270 44 control control NN cord-337849-tyabf12r 270 45 of of IN cord-337849-tyabf12r 270 46 pandemic pandemic JJ cord-337849-tyabf12r 270 47 H1N1 H1N1 NNP cord-337849-tyabf12r 270 48 influenza influenza NN cord-337849-tyabf12r 270 49 virus virus NN cord-337849-tyabf12r 270 50 infection infection NN cord-337849-tyabf12r 270 51 of of IN cord-337849-tyabf12r 270 52 macaques macaque NNS cord-337849-tyabf12r 270 53 Complement complement VBP cord-337849-tyabf12r 270 54 and and CC cord-337849-tyabf12r 270 55 viral viral JJ cord-337849-tyabf12r 270 56 pathogenesis pathogenesis NN cord-337849-tyabf12r 271 1 Influenza Influenza NNP cord-337849-tyabf12r 271 2 A a DT cord-337849-tyabf12r 271 3 virus virus NN cord-337849-tyabf12r 271 4 M1 M1 NNP cord-337849-tyabf12r 271 5 blocks block VBZ cord-337849-tyabf12r 271 6 the the DT cord-337849-tyabf12r 271 7 classical classical JJ cord-337849-tyabf12r 271 8 complement complement NN cord-337849-tyabf12r 271 9 pathway pathway NN cord-337849-tyabf12r 271 10 through through IN cord-337849-tyabf12r 271 11 interacting interact VBG cord-337849-tyabf12r 271 12 with with IN cord-337849-tyabf12r 271 13 C1qA C1qA NNS cord-337849-tyabf12r 271 14 Pharmacokinetics pharmacokinetic NNS cord-337849-tyabf12r 271 15 of of IN cord-337849-tyabf12r 271 16 vitamin vitamin NN cord-337849-tyabf12r 271 17 D d NN cord-337849-tyabf12r 271 18 toxicity toxicity NN cord-337849-tyabf12r 272 1 Serum serum NN cord-337849-tyabf12r 272 2 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 272 3 D d NN cord-337849-tyabf12r 272 4 is be VBZ cord-337849-tyabf12r 272 5 a a DT cord-337849-tyabf12r 272 6 reliable reliable JJ cord-337849-tyabf12r 272 7 indicator indicator NN cord-337849-tyabf12r 272 8 of of IN cord-337849-tyabf12r 272 9 vitamin vitamin NN cord-337849-tyabf12r 272 10 D d NN cord-337849-tyabf12r 272 11 status status NN cord-337849-tyabf12r 272 12 Vitamin vitamin NN cord-337849-tyabf12r 272 13 D d NN cord-337849-tyabf12r 272 14 supplementation supplementation NN cord-337849-tyabf12r 272 15 , , , cord-337849-tyabf12r 272 16 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 272 17 D d NN cord-337849-tyabf12r 272 18 concentrations concentration NNS cord-337849-tyabf12r 272 19 , , , cord-337849-tyabf12r 272 20 and and CC cord-337849-tyabf12r 272 21 safety safety NN cord-337849-tyabf12r 272 22 Steroid steroid NN cord-337849-tyabf12r 272 23 - - HYPH cord-337849-tyabf12r 272 24 hormone hormone NN cord-337849-tyabf12r 272 25 rapid rapid JJ cord-337849-tyabf12r 272 26 actions action NNS cord-337849-tyabf12r 272 27 , , , cord-337849-tyabf12r 272 28 membrane membrane NN cord-337849-tyabf12r 272 29 receptors receptor NNS cord-337849-tyabf12r 272 30 and and CC cord-337849-tyabf12r 272 31 a a DT cord-337849-tyabf12r 272 32 conformational conformational JJ cord-337849-tyabf12r 272 33 ensemble ensemble NN cord-337849-tyabf12r 272 34 model model NN cord-337849-tyabf12r 273 1 The the DT cord-337849-tyabf12r 273 2 vitamin vitamin NN cord-337849-tyabf12r 273 3 D d NN cord-337849-tyabf12r 273 4 receptor receptor NN cord-337849-tyabf12r 273 5 is be VBZ cord-337849-tyabf12r 273 6 present present JJ cord-337849-tyabf12r 273 7 in in IN cord-337849-tyabf12r 273 8 caveolae caveolae NNP cord-337849-tyabf12r 273 9 - - HYPH cord-337849-tyabf12r 273 10 enriched enrich VBN cord-337849-tyabf12r 273 11 plamsa plamsa NN cord-337849-tyabf12r 273 12 membranes membrane NNS cord-337849-tyabf12r 273 13 and and CC cord-337849-tyabf12r 273 14 binds bind VBZ cord-337849-tyabf12r 273 15 1 1 CD cord-337849-tyabf12r 273 16 alpha,25(OH)2-vitamin alpha,25(oh)2-vitamin CD cord-337849-tyabf12r 273 17 D3 D3 NNP cord-337849-tyabf12r 273 18 in in IN cord-337849-tyabf12r 273 19 vivo vivo NN cord-337849-tyabf12r 273 20 and and CC cord-337849-tyabf12r 274 1 in in FW cord-337849-tyabf12r 274 2 vitro vitro FW cord-337849-tyabf12r 274 3 Vitamin vitamin NN cord-337849-tyabf12r 274 4 D d NN cord-337849-tyabf12r 274 5 receptor receptor NN cord-337849-tyabf12r 274 6 : : : cord-337849-tyabf12r 275 1 New new JJ cord-337849-tyabf12r 275 2 assignments assignment NNS cord-337849-tyabf12r 275 3 for for IN cord-337849-tyabf12r 275 4 an an DT cord-337849-tyabf12r 275 5 already already RB cord-337849-tyabf12r 275 6 busy busy JJ cord-337849-tyabf12r 275 7 receptor receptor NN cord-337849-tyabf12r 275 8 The the DT cord-337849-tyabf12r 275 9 yin yin NNP cord-337849-tyabf12r 275 10 and and CC cord-337849-tyabf12r 275 11 yang yang NNP cord-337849-tyabf12r 275 12 of of IN cord-337849-tyabf12r 275 13 vitamin vitamin NN cord-337849-tyabf12r 275 14 D D NNP cord-337849-tyabf12r 275 15 receptor receptor NN cord-337849-tyabf12r 275 16 ( ( -LRB- cord-337849-tyabf12r 275 17 VDR VDR NNP cord-337849-tyabf12r 275 18 ) ) -RRB- cord-337849-tyabf12r 275 19 signaling signal VBG cord-337849-tyabf12r 275 20 in in IN cord-337849-tyabf12r 275 21 neoplastic neoplastic JJ cord-337849-tyabf12r 275 22 progression progression NN cord-337849-tyabf12r 275 23 : : : cord-337849-tyabf12r 275 24 Operational operational JJ cord-337849-tyabf12r 275 25 networks network NNS cord-337849-tyabf12r 275 26 and and CC cord-337849-tyabf12r 275 27 tissue tissue NN cord-337849-tyabf12r 275 28 - - HYPH cord-337849-tyabf12r 275 29 specific specific JJ cord-337849-tyabf12r 275 30 growth growth NN cord-337849-tyabf12r 275 31 control control NN cord-337849-tyabf12r 275 32 Manolagas Manolagas NNP cord-337849-tyabf12r 275 33 , , , cord-337849-tyabf12r 275 34 S. S. NNP cord-337849-tyabf12r 275 35 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 275 36 D3 D3 NNP cord-337849-tyabf12r 275 37 receptors receptor NNS cord-337849-tyabf12r 275 38 in in IN cord-337849-tyabf12r 275 39 human human JJ cord-337849-tyabf12r 275 40 leukocytes leukocyte NNS cord-337849-tyabf12r 275 41 Human Human NNP cord-337849-tyabf12r 275 42 T T NNP cord-337849-tyabf12r 275 43 lymphocytes lymphocyte NNS cord-337849-tyabf12r 275 44 are be VBP cord-337849-tyabf12r 275 45 direct direct JJ cord-337849-tyabf12r 275 46 targets target NNS cord-337849-tyabf12r 275 47 of of IN cord-337849-tyabf12r 275 48 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 275 49 D3 D3 NNP cord-337849-tyabf12r 275 50 in in IN cord-337849-tyabf12r 275 51 the the DT cord-337849-tyabf12r 275 52 immune immune JJ cord-337849-tyabf12r 275 53 system system NN cord-337849-tyabf12r 275 54 Differential differential JJ cord-337849-tyabf12r 275 55 regulation regulation NN cord-337849-tyabf12r 275 56 of of IN cord-337849-tyabf12r 275 57 vitamin vitamin NN cord-337849-tyabf12r 275 58 D d NN cord-337849-tyabf12r 275 59 receptor receptor NN cord-337849-tyabf12r 275 60 and and CC cord-337849-tyabf12r 275 61 its -PRON- PRP$ cord-337849-tyabf12r 275 62 ligand ligand NN cord-337849-tyabf12r 275 63 in in IN cord-337849-tyabf12r 275 64 human human JJ cord-337849-tyabf12r 275 65 monocyte monocyte NNP cord-337849-tyabf12r 275 66 - - HYPH cord-337849-tyabf12r 275 67 derived derive VBN cord-337849-tyabf12r 275 68 dendritic dendritic JJ cord-337849-tyabf12r 275 69 cells cell NNS cord-337849-tyabf12r 276 1 Modulatory modulatory JJ cord-337849-tyabf12r 276 2 effects effect NNS cord-337849-tyabf12r 276 3 of of IN cord-337849-tyabf12r 276 4 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 276 5 D3 D3 NNP cord-337849-tyabf12r 276 6 on on IN cord-337849-tyabf12r 276 7 human human JJ cord-337849-tyabf12r 276 8 B b NN cord-337849-tyabf12r 276 9 cell cell NN cord-337849-tyabf12r 276 10 differentiation differentiation NN cord-337849-tyabf12r 276 11 DCs dc NNS cord-337849-tyabf12r 276 12 metabolize metabolize VBP cord-337849-tyabf12r 276 13 sunlight sunlight NN cord-337849-tyabf12r 276 14 - - HYPH cord-337849-tyabf12r 276 15 induced induce VBN cord-337849-tyabf12r 276 16 vitamin vitamin NN cord-337849-tyabf12r 276 17 D3 D3 NNP cord-337849-tyabf12r 276 18 to to IN cord-337849-tyabf12r 276 19 ' ' `` cord-337849-tyabf12r 276 20 program program NN cord-337849-tyabf12r 276 21 ' ' '' cord-337849-tyabf12r 276 22 T T NNP cord-337849-tyabf12r 276 23 cell cell NN cord-337849-tyabf12r 276 24 attraction attraction NN cord-337849-tyabf12r 276 25 to to IN cord-337849-tyabf12r 276 26 the the DT cord-337849-tyabf12r 276 27 epidermal epidermal JJ cord-337849-tyabf12r 276 28 chemokine chemokine NN cord-337849-tyabf12r 277 1 CCL27 CCL27 NNP cord-337849-tyabf12r 277 2 Does do VBZ cord-337849-tyabf12r 277 3 vitamin vitamin NN cord-337849-tyabf12r 277 4 D d NN cord-337849-tyabf12r 277 5 affect affect VBP cord-337849-tyabf12r 277 6 risk risk NN cord-337849-tyabf12r 277 7 of of IN cord-337849-tyabf12r 277 8 developing develop VBG cord-337849-tyabf12r 277 9 autoimmune autoimmune JJ cord-337849-tyabf12r 277 10 disease disease NN cord-337849-tyabf12r 277 11 ? ? . cord-337849-tyabf12r 278 1 : : : cord-337849-tyabf12r 279 1 A a DT cord-337849-tyabf12r 279 2 systematic systematic JJ cord-337849-tyabf12r 279 3 review review NN cord-337849-tyabf12r 280 1 The the DT cord-337849-tyabf12r 280 2 role role NN cord-337849-tyabf12r 280 3 of of IN cord-337849-tyabf12r 280 4 vitamin vitamin NN cord-337849-tyabf12r 280 5 D d NN cord-337849-tyabf12r 280 6 in in IN cord-337849-tyabf12r 280 7 cancer cancer NN cord-337849-tyabf12r 280 8 prevention prevention NN cord-337849-tyabf12r 280 9 and and CC cord-337849-tyabf12r 280 10 treatment treatment NN cord-337849-tyabf12r 280 11 Vitamin vitamin NN cord-337849-tyabf12r 280 12 D d NN cord-337849-tyabf12r 280 13 deficiency deficiency NN cord-337849-tyabf12r 280 14 and and CC cord-337849-tyabf12r 280 15 risk risk NN cord-337849-tyabf12r 280 16 of of IN cord-337849-tyabf12r 280 17 cardiovascular cardiovascular JJ cord-337849-tyabf12r 280 18 disease disease NNP cord-337849-tyabf12r 280 19 Association Association NNP cord-337849-tyabf12r 280 20 between between IN cord-337849-tyabf12r 280 21 serum serum NN cord-337849-tyabf12r 280 22 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 280 23 D d NN cord-337849-tyabf12r 280 24 level level NN cord-337849-tyabf12r 280 25 and and CC cord-337849-tyabf12r 280 26 upper upper JJ cord-337849-tyabf12r 280 27 respiratory respiratory JJ cord-337849-tyabf12r 280 28 tract tract NN cord-337849-tyabf12r 280 29 infection infection NN cord-337849-tyabf12r 280 30 in in IN cord-337849-tyabf12r 280 31 the the DT cord-337849-tyabf12r 280 32 Third Third NNP cord-337849-tyabf12r 280 33 National National NNP cord-337849-tyabf12r 280 34 Health Health NNP cord-337849-tyabf12r 280 35 and and CC cord-337849-tyabf12r 280 36 Nutrition Nutrition NNP cord-337849-tyabf12r 280 37 Examination Examination NNP cord-337849-tyabf12r 280 38 Survey Survey NNP cord-337849-tyabf12r 280 39 Regulated regulated JJ cord-337849-tyabf12r 280 40 production production NN cord-337849-tyabf12r 280 41 and and CC cord-337849-tyabf12r 280 42 intracrine intracrine JJ cord-337849-tyabf12r 280 43 action action NN cord-337849-tyabf12r 280 44 of of IN cord-337849-tyabf12r 280 45 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 280 46 D3 D3 NNP cord-337849-tyabf12r 280 47 in in IN cord-337849-tyabf12r 280 48 the the DT cord-337849-tyabf12r 280 49 chick chick NNP cord-337849-tyabf12r 280 50 myelomonocytic myelomonocytic NNP cord-337849-tyabf12r 280 51 cell cell NN cord-337849-tyabf12r 280 52 line line NN cord-337849-tyabf12r 280 53 HD-11 HD-11 NNP cord-337849-tyabf12r 280 54 Regulation Regulation NNP cord-337849-tyabf12r 280 55 of of IN cord-337849-tyabf12r 280 56 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 280 57 D3 D3 NNP cord-337849-tyabf12r 280 58 production production NN cord-337849-tyabf12r 280 59 by by IN cord-337849-tyabf12r 280 60 cultured cultured JJ cord-337849-tyabf12r 280 61 alveolar alveolar NN cord-337849-tyabf12r 280 62 macrophages macrophage NNS cord-337849-tyabf12r 280 63 from from IN cord-337849-tyabf12r 280 64 normal normal JJ cord-337849-tyabf12r 280 65 human human JJ cord-337849-tyabf12r 280 66 donors donor NNS cord-337849-tyabf12r 280 67 and and CC cord-337849-tyabf12r 280 68 from from IN cord-337849-tyabf12r 280 69 patients patient NNS cord-337849-tyabf12r 280 70 with with IN cord-337849-tyabf12r 280 71 pulmonary pulmonary JJ cord-337849-tyabf12r 280 72 sarcoidosis sarcoidosis NN cord-337849-tyabf12r 280 73 Regulation regulation NN cord-337849-tyabf12r 280 74 of of IN cord-337849-tyabf12r 280 75 1 1 CD cord-337849-tyabf12r 280 76 alpha alpha NN cord-337849-tyabf12r 280 77 , , , cord-337849-tyabf12r 280 78 25-dihydroxyvitamin 25-dihydroxyvitamin CD cord-337849-tyabf12r 280 79 D3 D3 NNP cord-337849-tyabf12r 280 80 synthesis synthesis NN cord-337849-tyabf12r 280 81 in in IN cord-337849-tyabf12r 280 82 macrophages macrophage NNS cord-337849-tyabf12r 280 83 from from IN cord-337849-tyabf12r 280 84 arthritic arthritic JJ cord-337849-tyabf12r 280 85 joints joint NNS cord-337849-tyabf12r 280 86 by by IN cord-337849-tyabf12r 280 87 phorbol phorbol NNP cord-337849-tyabf12r 280 88 ester ester NNP cord-337849-tyabf12r 280 89 , , , cord-337849-tyabf12r 281 1 dibutyryl dibutyryl NN cord-337849-tyabf12r 281 2 - - HYPH cord-337849-tyabf12r 281 3 cAMP camp NN cord-337849-tyabf12r 281 4 and and CC cord-337849-tyabf12r 281 5 calcium calcium NN cord-337849-tyabf12r 281 6 ionophore ionophore NNP cord-337849-tyabf12r 281 7 ( ( -LRB- cord-337849-tyabf12r 281 8 A23187 A23187 NNP cord-337849-tyabf12r 281 9 ) ) -RRB- cord-337849-tyabf12r 282 1 Alternative alternative JJ cord-337849-tyabf12r 282 2 splicing splicing NN cord-337849-tyabf12r 282 3 of of IN cord-337849-tyabf12r 282 4 vitamin vitamin NN cord-337849-tyabf12r 283 1 D-24-hydroxylase D-24-hydroxylase NNP cord-337849-tyabf12r 283 2 : : : cord-337849-tyabf12r 284 1 A a DT cord-337849-tyabf12r 284 2 novel novel JJ cord-337849-tyabf12r 284 3 mechanism mechanism NN cord-337849-tyabf12r 284 4 for for IN cord-337849-tyabf12r 284 5 the the DT cord-337849-tyabf12r 284 6 regulation regulation NN cord-337849-tyabf12r 284 7 of of IN cord-337849-tyabf12r 284 8 extrarenal extrarenal JJ cord-337849-tyabf12r 284 9 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 284 10 D D NNP cord-337849-tyabf12r 284 11 synthesis synthesis NN cord-337849-tyabf12r 284 12 Vitamin vitamin NN cord-337849-tyabf12r 284 13 D d NN cord-337849-tyabf12r 284 14 signaling signaling NN cord-337849-tyabf12r 284 15 , , , cord-337849-tyabf12r 284 16 infectious infectious JJ cord-337849-tyabf12r 284 17 diseases disease NNS cord-337849-tyabf12r 284 18 , , , cord-337849-tyabf12r 284 19 and and CC cord-337849-tyabf12r 284 20 regulation regulation NN cord-337849-tyabf12r 284 21 of of IN cord-337849-tyabf12r 284 22 innate innate JJ cord-337849-tyabf12r 284 23 immunity immunity NN cord-337849-tyabf12r 284 24 Regulation regulation NN cord-337849-tyabf12r 284 25 of of IN cord-337849-tyabf12r 284 26 intracrine intracrine JJ cord-337849-tyabf12r 284 27 production production NN cord-337849-tyabf12r 284 28 of of IN cord-337849-tyabf12r 284 29 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 284 30 D d NN cord-337849-tyabf12r 284 31 and and CC cord-337849-tyabf12r 284 32 its -PRON- PRP$ cord-337849-tyabf12r 284 33 role role NN cord-337849-tyabf12r 284 34 in in IN cord-337849-tyabf12r 284 35 innate innate JJ cord-337849-tyabf12r 284 36 immune immune JJ cord-337849-tyabf12r 284 37 defense defense NN cord-337849-tyabf12r 284 38 against against IN cord-337849-tyabf12r 284 39 infection infection NN cord-337849-tyabf12r 285 1 Toll toll NN cord-337849-tyabf12r 285 2 - - HYPH cord-337849-tyabf12r 285 3 like like JJ cord-337849-tyabf12r 285 4 receptor receptor NN cord-337849-tyabf12r 285 5 8 8 CD cord-337849-tyabf12r 285 6 ligands ligand NNS cord-337849-tyabf12r 285 7 activate activate VBP cord-337849-tyabf12r 285 8 a a DT cord-337849-tyabf12r 285 9 vitamin vitamin NN cord-337849-tyabf12r 285 10 D d NN cord-337849-tyabf12r 285 11 mediated mediate VBN cord-337849-tyabf12r 285 12 autophagic autophagic JJ cord-337849-tyabf12r 285 13 response response NN cord-337849-tyabf12r 285 14 that that WDT cord-337849-tyabf12r 285 15 inhibits inhibit VBZ cord-337849-tyabf12r 285 16 human human JJ cord-337849-tyabf12r 285 17 immunodeficiency immunodeficiency NN cord-337849-tyabf12r 285 18 virus virus NN cord-337849-tyabf12r 285 19 type type NN cord-337849-tyabf12r 285 20 1 1 CD cord-337849-tyabf12r 285 21 Increased increase VBN cord-337849-tyabf12r 285 22 expression expression NN cord-337849-tyabf12r 285 23 of of IN cord-337849-tyabf12r 285 24 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 285 25 D-1alpha D-1alpha NNP cord-337849-tyabf12r 285 26 - - HYPH cord-337849-tyabf12r 285 27 hydroxylase hydroxylase NN cord-337849-tyabf12r 285 28 in in IN cord-337849-tyabf12r 285 29 dysgerminomas dysgerminomas NNP cord-337849-tyabf12r 285 30 : : : cord-337849-tyabf12r 285 31 A a DT cord-337849-tyabf12r 285 32 novel novel JJ cord-337849-tyabf12r 285 33 form form NN cord-337849-tyabf12r 285 34 of of IN cord-337849-tyabf12r 285 35 humoral humoral JJ cord-337849-tyabf12r 285 36 hypercalcemia hypercalcemia NN cord-337849-tyabf12r 285 37 of of IN cord-337849-tyabf12r 285 38 malignancy malignancy NN cord-337849-tyabf12r 285 39 Immune immune JJ cord-337849-tyabf12r 285 40 regulation regulation NN cord-337849-tyabf12r 285 41 of of IN cord-337849-tyabf12r 285 42 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 285 43 - - HYPH cord-337849-tyabf12r 285 44 D3 d3 NN cord-337849-tyabf12r 285 45 - - HYPH cord-337849-tyabf12r 285 46 1alpha 1alpha CD cord-337849-tyabf12r 285 47 - - HYPH cord-337849-tyabf12r 285 48 hydroxylase hydroxylase NN cord-337849-tyabf12r 285 49 in in IN cord-337849-tyabf12r 285 50 human human JJ cord-337849-tyabf12r 285 51 monocytes monocyte NNS cord-337849-tyabf12r 285 52 Regulation regulation NN cord-337849-tyabf12r 285 53 of of IN cord-337849-tyabf12r 285 54 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 285 55 D3 D3 NNP cord-337849-tyabf12r 285 56 - - HYPH cord-337849-tyabf12r 285 57 1 1 CD cord-337849-tyabf12r 285 58 alpha alpha NN cord-337849-tyabf12r 285 59 - - HYPH cord-337849-tyabf12r 285 60 hydroxylase hydroxylase NN cord-337849-tyabf12r 285 61 and and CC cord-337849-tyabf12r 285 62 production production NN cord-337849-tyabf12r 285 63 of of IN cord-337849-tyabf12r 285 64 1 1 CD cord-337849-tyabf12r 285 65 alpha,25-dihydroxyvitamin alpha,25-dihydroxyvitamin NN cord-337849-tyabf12r 285 66 D3 D3 NNP cord-337849-tyabf12r 285 67 by by IN cord-337849-tyabf12r 285 68 human human JJ cord-337849-tyabf12r 285 69 dendritic dendritic JJ cord-337849-tyabf12r 285 70 cells cell NNS cord-337849-tyabf12r 286 1 TLR TLR NNP cord-337849-tyabf12r 286 2 - - HYPH cord-337849-tyabf12r 286 3 induced induce VBN cord-337849-tyabf12r 286 4 local local JJ cord-337849-tyabf12r 286 5 metabolism metabolism NN cord-337849-tyabf12r 286 6 of of IN cord-337849-tyabf12r 286 7 vitamin vitamin NN cord-337849-tyabf12r 286 8 D3 D3 NNP cord-337849-tyabf12r 286 9 plays play VBZ cord-337849-tyabf12r 286 10 an an DT cord-337849-tyabf12r 286 11 important important JJ cord-337849-tyabf12r 286 12 role role NN cord-337849-tyabf12r 286 13 in in IN cord-337849-tyabf12r 286 14 the the DT cord-337849-tyabf12r 286 15 diversification diversification NN cord-337849-tyabf12r 286 16 of of IN cord-337849-tyabf12r 286 17 adaptive adaptive JJ cord-337849-tyabf12r 286 18 immune immune JJ cord-337849-tyabf12r 286 19 responses response NNS cord-337849-tyabf12r 286 20 TLR TLR NNP cord-337849-tyabf12r 286 21 ligands ligand NNS cord-337849-tyabf12r 286 22 that that WDT cord-337849-tyabf12r 286 23 stimulate stimulate VBP cord-337849-tyabf12r 286 24 the the DT cord-337849-tyabf12r 286 25 metabolism metabolism NN cord-337849-tyabf12r 286 26 of of IN cord-337849-tyabf12r 286 27 vitamin vitamin NN cord-337849-tyabf12r 286 28 D3 D3 NNP cord-337849-tyabf12r 286 29 in in IN cord-337849-tyabf12r 286 30 activated activate VBN cord-337849-tyabf12r 286 31 murine murine JJ cord-337849-tyabf12r 286 32 dendritic dendritic JJ cord-337849-tyabf12r 286 33 cells cell NNS cord-337849-tyabf12r 286 34 can can MD cord-337849-tyabf12r 286 35 function function VB cord-337849-tyabf12r 286 36 as as IN cord-337849-tyabf12r 286 37 effective effective JJ cord-337849-tyabf12r 286 38 mucosal mucosal JJ cord-337849-tyabf12r 286 39 adjuvants adjuvant NNS cord-337849-tyabf12r 286 40 to to IN cord-337849-tyabf12r 286 41 subcutaneously subcutaneously RB cord-337849-tyabf12r 286 42 administered administer VBN cord-337849-tyabf12r 286 43 vaccines vaccine NNS cord-337849-tyabf12r 286 44 Respiratory respiratory JJ cord-337849-tyabf12r 286 45 epithelial epithelial JJ cord-337849-tyabf12r 286 46 cells cell NNS cord-337849-tyabf12r 286 47 convert convert VBP cord-337849-tyabf12r 286 48 inactive inactive JJ cord-337849-tyabf12r 286 49 vitamin vitamin NN cord-337849-tyabf12r 286 50 D d NN cord-337849-tyabf12r 286 51 to to IN cord-337849-tyabf12r 286 52 its -PRON- PRP$ cord-337849-tyabf12r 286 53 active active JJ cord-337849-tyabf12r 286 54 form form NN cord-337849-tyabf12r 286 55 : : : cord-337849-tyabf12r 286 56 Potential potential JJ cord-337849-tyabf12r 286 57 effects effect NNS cord-337849-tyabf12r 286 58 on on IN cord-337849-tyabf12r 286 59 host host NN cord-337849-tyabf12r 286 60 defense defense NN cord-337849-tyabf12r 286 61 Modlin Modlin NNP cord-337849-tyabf12r 286 62 , , , cord-337849-tyabf12r 286 63 R. R. NNP cord-337849-tyabf12r 286 64 IL-15 IL-15 NNP cord-337849-tyabf12r 286 65 links link VBZ cord-337849-tyabf12r 286 66 TLR2/1-induced tlr2/1-induced CD cord-337849-tyabf12r 286 67 macrophage macrophage NN cord-337849-tyabf12r 286 68 differentiaition differentiaition NN cord-337849-tyabf12r 286 69 to to IN cord-337849-tyabf12r 286 70 the the DT cord-337849-tyabf12r 286 71 vitamin vitamin NN cord-337849-tyabf12r 286 72 D d NN cord-337849-tyabf12r 286 73 - - HYPH cord-337849-tyabf12r 286 74 dependent dependent JJ cord-337849-tyabf12r 286 75 antimicrobial antimicrobial JJ cord-337849-tyabf12r 286 76 pathway pathway NN cord-337849-tyabf12r 286 77 Interleukin Interleukin NNP cord-337849-tyabf12r 287 1 13 13 CD cord-337849-tyabf12r 287 2 exposure exposure NN cord-337849-tyabf12r 287 3 enhances enhance VBZ cord-337849-tyabf12r 287 4 vitamin vitamin NN cord-337849-tyabf12r 287 5 D d NN cord-337849-tyabf12r 287 6 - - HYPH cord-337849-tyabf12r 287 7 mediated mediate VBN cord-337849-tyabf12r 287 8 expression expression NN cord-337849-tyabf12r 287 9 of of IN cord-337849-tyabf12r 287 10 the the DT cord-337849-tyabf12r 287 11 human human JJ cord-337849-tyabf12r 287 12 cathelicidin cathelicidin NNP cord-337849-tyabf12r 287 13 antimicrobial antimicrobial NNP cord-337849-tyabf12r 287 14 peptide peptide NNP cord-337849-tyabf12r 287 15 18 18 CD cord-337849-tyabf12r 287 16 / / SYM cord-337849-tyabf12r 287 17 LL-37 LL-37 NNP cord-337849-tyabf12r 287 18 in in IN cord-337849-tyabf12r 287 19 bronchial bronchial JJ cord-337849-tyabf12r 287 20 epithelial epithelial JJ cord-337849-tyabf12r 287 21 cells cell NNS cord-337849-tyabf12r 287 22 Immune immune VBP cord-337849-tyabf12r 287 23 regulation regulation NN cord-337849-tyabf12r 287 24 of of IN cord-337849-tyabf12r 287 25 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 287 26 D-1 D-1 NNP cord-337849-tyabf12r 287 27 alpha alpha NN cord-337849-tyabf12r 287 28 - - HYPH cord-337849-tyabf12r 287 29 hydroxylase hydroxylase NN cord-337849-tyabf12r 287 30 in in IN cord-337849-tyabf12r 287 31 human human JJ cord-337849-tyabf12r 287 32 monocytic monocytic JJ cord-337849-tyabf12r 287 33 THP1 THP1 NNP cord-337849-tyabf12r 287 34 cells cell NNS cord-337849-tyabf12r 287 35 : : : cord-337849-tyabf12r 287 36 Mechanisms mechanism NNS cord-337849-tyabf12r 287 37 of of IN cord-337849-tyabf12r 287 38 interferon interferon NN cord-337849-tyabf12r 287 39 - - HYPH cord-337849-tyabf12r 287 40 gamma gamma NN cord-337849-tyabf12r 287 41 - - HYPH cord-337849-tyabf12r 287 42 mediated mediate VBN cord-337849-tyabf12r 287 43 induction induction NN cord-337849-tyabf12r 287 44 T t NN cord-337849-tyabf12r 287 45 - - HYPH cord-337849-tyabf12r 287 46 cell cell NN cord-337849-tyabf12r 287 47 cytokines cytokine NNS cord-337849-tyabf12r 287 48 differentially differentially RB cord-337849-tyabf12r 287 49 control control VBP cord-337849-tyabf12r 287 50 human human JJ cord-337849-tyabf12r 287 51 monocyte monocyte NNP cord-337849-tyabf12r 287 52 antimicrobial antimicrobial JJ cord-337849-tyabf12r 287 53 responses response NNS cord-337849-tyabf12r 287 54 by by IN cord-337849-tyabf12r 287 55 regulating regulate VBG cord-337849-tyabf12r 287 56 vitamin vitamin NN cord-337849-tyabf12r 287 57 D d NN cord-337849-tyabf12r 287 58 metabolism metabolism NN cord-337849-tyabf12r 288 1 Monocyte Monocyte NNP cord-337849-tyabf12r 288 2 1 1 CD cord-337849-tyabf12r 288 3 alpha alpha NN cord-337849-tyabf12r 288 4 - - HYPH cord-337849-tyabf12r 288 5 hydroxylase hydroxylase NN cord-337849-tyabf12r 288 6 regulation regulation NN cord-337849-tyabf12r 288 7 : : : cord-337849-tyabf12r 288 8 Induction induction NN cord-337849-tyabf12r 288 9 by by IN cord-337849-tyabf12r 288 10 inflammatory inflammatory JJ cord-337849-tyabf12r 288 11 cytokines cytokine NNS cord-337849-tyabf12r 288 12 and and CC cord-337849-tyabf12r 288 13 suppression suppression NN cord-337849-tyabf12r 288 14 by by IN cord-337849-tyabf12r 288 15 dexamethasone dexamethasone NN cord-337849-tyabf12r 288 16 and and CC cord-337849-tyabf12r 288 17 uremia uremia NN cord-337849-tyabf12r 288 18 toxin toxin NN cord-337849-tyabf12r 289 1 New new JJ cord-337849-tyabf12r 289 2 analogs analog NNS cord-337849-tyabf12r 289 3 of of IN cord-337849-tyabf12r 289 4 vitamin vitamin NN cord-337849-tyabf12r 289 5 D3 D3 NNP cord-337849-tyabf12r 290 1 The the DT cord-337849-tyabf12r 290 2 multiple multiple JJ cord-337849-tyabf12r 290 3 faces face NNS cord-337849-tyabf12r 290 4 of of IN cord-337849-tyabf12r 290 5 caveolae caveolae NNP cord-337849-tyabf12r 290 6 Identification Identification NNP cord-337849-tyabf12r 290 7 of of IN cord-337849-tyabf12r 290 8 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 290 9 D3 D3 NNP cord-337849-tyabf12r 290 10 1alpha 1alpha CD cord-337849-tyabf12r 290 11 - - HYPH cord-337849-tyabf12r 290 12 hydroxylase hydroxylase NN cord-337849-tyabf12r 290 13 gene gene NN cord-337849-tyabf12r 290 14 expression expression NN cord-337849-tyabf12r 290 15 in in IN cord-337849-tyabf12r 290 16 macrophages macrophage NNS cord-337849-tyabf12r 290 17 Human human JJ cord-337849-tyabf12r 290 18 cathelicidin cathelicidin NNS cord-337849-tyabf12r 290 19 , , , cord-337849-tyabf12r 290 20 hCAP-18 hcap-18 ADD cord-337849-tyabf12r 290 21 , , , cord-337849-tyabf12r 290 22 is be VBZ cord-337849-tyabf12r 290 23 processed process VBN cord-337849-tyabf12r 290 24 to to IN cord-337849-tyabf12r 290 25 the the DT cord-337849-tyabf12r 290 26 antimicrobial antimicrobial JJ cord-337849-tyabf12r 290 27 peptide peptide NN cord-337849-tyabf12r 290 28 LL-37 LL-37 NNP cord-337849-tyabf12r 290 29 by by IN cord-337849-tyabf12r 290 30 extracellular extracellular JJ cord-337849-tyabf12r 290 31 cleavage cleavage NN cord-337849-tyabf12r 290 32 with with IN cord-337849-tyabf12r 290 33 proteinase proteinase NN cord-337849-tyabf12r 290 34 3 3 CD cord-337849-tyabf12r 291 1 The the DT cord-337849-tyabf12r 291 2 human human JJ cord-337849-tyabf12r 291 3 antimicrobial antimicrobial NN cord-337849-tyabf12r 291 4 and and CC cord-337849-tyabf12r 291 5 chemotactic chemotactic JJ cord-337849-tyabf12r 291 6 peptides peptide NNS cord-337849-tyabf12r 291 7 LL-37 LL-37 NNP cord-337849-tyabf12r 291 8 and and CC cord-337849-tyabf12r 291 9 alpha alpha NN cord-337849-tyabf12r 291 10 - - HYPH cord-337849-tyabf12r 291 11 defensins defensin NNS cord-337849-tyabf12r 291 12 are be VBP cord-337849-tyabf12r 291 13 expressed express VBN cord-337849-tyabf12r 291 14 by by IN cord-337849-tyabf12r 291 15 specific specific JJ cord-337849-tyabf12r 291 16 lymphocyte lymphocyte NN cord-337849-tyabf12r 291 17 and and CC cord-337849-tyabf12r 291 18 monocyte monocyte NNP cord-337849-tyabf12r 291 19 populations population NNS cord-337849-tyabf12r 292 1 The the DT cord-337849-tyabf12r 292 2 peptide peptide NN cord-337849-tyabf12r 292 3 antibiotic antibiotic JJ cord-337849-tyabf12r 292 4 LL-37 LL-37 NNP cord-337849-tyabf12r 292 5 / / SYM cord-337849-tyabf12r 292 6 hCAP-18 hcap-18 CD cord-337849-tyabf12r 292 7 is be VBZ cord-337849-tyabf12r 292 8 expressed express VBN cord-337849-tyabf12r 292 9 in in IN cord-337849-tyabf12r 292 10 epithelia epithelium NNS cord-337849-tyabf12r 292 11 of of IN cord-337849-tyabf12r 292 12 the the DT cord-337849-tyabf12r 292 13 human human JJ cord-337849-tyabf12r 292 14 lung lung NN cord-337849-tyabf12r 292 15 where where WRB cord-337849-tyabf12r 292 16 it -PRON- PRP cord-337849-tyabf12r 292 17 has have VBZ cord-337849-tyabf12r 292 18 broad broad JJ cord-337849-tyabf12r 292 19 antimicrobial antimicrobial JJ cord-337849-tyabf12r 292 20 activity activity NN cord-337849-tyabf12r 292 21 at at IN cord-337849-tyabf12r 292 22 the the DT cord-337849-tyabf12r 292 23 airway airway NN cord-337849-tyabf12r 292 24 surface surface NN cord-337849-tyabf12r 292 25 LL-37 LL-37 NNP cord-337849-tyabf12r 292 26 , , , cord-337849-tyabf12r 292 27 the the DT cord-337849-tyabf12r 292 28 neutrophil neutrophil NN cord-337849-tyabf12r 292 29 granule granule NN cord-337849-tyabf12r 292 30 - - : cord-337849-tyabf12r 292 31 and and CC cord-337849-tyabf12r 292 32 epithelial epithelial JJ cord-337849-tyabf12r 292 33 cell cell NN cord-337849-tyabf12r 292 34 - - HYPH cord-337849-tyabf12r 292 35 derived derive VBN cord-337849-tyabf12r 292 36 cathelicidin cathelicidin NNS cord-337849-tyabf12r 292 37 , , , cord-337849-tyabf12r 292 38 utilizes utilize VBZ cord-337849-tyabf12r 292 39 formyl formyl NNP cord-337849-tyabf12r 292 40 peptide peptide JJ cord-337849-tyabf12r 292 41 receptor receptor NN cord-337849-tyabf12r 292 42 - - HYPH cord-337849-tyabf12r 292 43 like like JJ cord-337849-tyabf12r 292 44 1 1 CD cord-337849-tyabf12r 292 45 ( ( -LRB- cord-337849-tyabf12r 292 46 FPRL1 FPRL1 NNP cord-337849-tyabf12r 292 47 ) ) -RRB- cord-337849-tyabf12r 292 48 as as IN cord-337849-tyabf12r 292 49 a a DT cord-337849-tyabf12r 292 50 receptor receptor NN cord-337849-tyabf12r 292 51 to to TO cord-337849-tyabf12r 292 52 chemoattract chemoattract VB cord-337849-tyabf12r 292 53 human human JJ cord-337849-tyabf12r 292 54 peripheral peripheral JJ cord-337849-tyabf12r 292 55 blood blood NN cord-337849-tyabf12r 292 56 neutrophils neutrophil NNS cord-337849-tyabf12r 292 57 , , , cord-337849-tyabf12r 292 58 monocytes monocyte NNS cord-337849-tyabf12r 292 59 , , , cord-337849-tyabf12r 292 60 and and CC cord-337849-tyabf12r 292 61 T t NN cord-337849-tyabf12r 292 62 cells cell NNS cord-337849-tyabf12r 293 1 Human human JJ cord-337849-tyabf12r 293 2 cathelicidin cathelicidin NN cord-337849-tyabf12r 293 3 LL-37 LL-37 NNP cord-337849-tyabf12r 293 4 is be VBZ cord-337849-tyabf12r 293 5 a a DT cord-337849-tyabf12r 293 6 chemoattractant chemoattractant NN cord-337849-tyabf12r 293 7 for for IN cord-337849-tyabf12r 293 8 eosinophils eosinophil NNS cord-337849-tyabf12r 293 9 and and CC cord-337849-tyabf12r 293 10 neutrophils neutrophil NNS cord-337849-tyabf12r 293 11 that that WDT cord-337849-tyabf12r 293 12 acts act VBZ cord-337849-tyabf12r 293 13 via via IN cord-337849-tyabf12r 293 14 formyl formyl NN cord-337849-tyabf12r 293 15 - - HYPH cord-337849-tyabf12r 293 16 peptide peptide NN cord-337849-tyabf12r 293 17 receptors receptor NNS cord-337849-tyabf12r 294 1 The the DT cord-337849-tyabf12r 294 2 human human JJ cord-337849-tyabf12r 294 3 antimicrobial antimicrobial NN cord-337849-tyabf12r 294 4 peptide peptide NN cord-337849-tyabf12r 294 5 LL-37 LL-37 NNP cord-337849-tyabf12r 294 6 is be VBZ cord-337849-tyabf12r 294 7 a a DT cord-337849-tyabf12r 294 8 multifunctional multifunctional JJ cord-337849-tyabf12r 294 9 modulator modulator NN cord-337849-tyabf12r 294 10 of of IN cord-337849-tyabf12r 294 11 innate innate JJ cord-337849-tyabf12r 294 12 immune immune JJ cord-337849-tyabf12r 294 13 responses response NNS cord-337849-tyabf12r 295 1 An an DT cord-337849-tyabf12r 295 2 antimicrobial antimicrobial JJ cord-337849-tyabf12r 295 3 cathelicidin cathelicidin NNP cord-337849-tyabf12r 295 4 peptide peptide NN cord-337849-tyabf12r 295 5 , , , cord-337849-tyabf12r 295 6 human human JJ cord-337849-tyabf12r 295 7 CAP18 CAP18 NNP cord-337849-tyabf12r 295 8 / / SYM cord-337849-tyabf12r 295 9 LL-37 LL-37 NNP cord-337849-tyabf12r 295 10 , , , cord-337849-tyabf12r 295 11 suppresses suppress VBZ cord-337849-tyabf12r 295 12 neutrophil neutrophil NN cord-337849-tyabf12r 295 13 apoptosis apoptosis NN cord-337849-tyabf12r 295 14 via via IN cord-337849-tyabf12r 295 15 the the DT cord-337849-tyabf12r 295 16 activation activation NN cord-337849-tyabf12r 295 17 of of IN cord-337849-tyabf12r 295 18 formyl formyl NNP cord-337849-tyabf12r 295 19 - - HYPH cord-337849-tyabf12r 295 20 peptide peptide NN cord-337849-tyabf12r 295 21 receptor receptor NN cord-337849-tyabf12r 295 22 - - HYPH cord-337849-tyabf12r 295 23 like like JJ cord-337849-tyabf12r 295 24 1 1 CD cord-337849-tyabf12r 295 25 and and CC cord-337849-tyabf12r 295 26 P2X7 P2X7 NNP cord-337849-tyabf12r 296 1 The the DT cord-337849-tyabf12r 296 2 cationic cationic JJ cord-337849-tyabf12r 296 3 antimicrobial antimicrobial NN cord-337849-tyabf12r 296 4 peptide peptide NN cord-337849-tyabf12r 296 5 LL-37 LL-37 NNP cord-337849-tyabf12r 296 6 modulates modulate VBZ cord-337849-tyabf12r 296 7 dendritic dendritic JJ cord-337849-tyabf12r 296 8 cell cell NN cord-337849-tyabf12r 296 9 differentiation differentiation NN cord-337849-tyabf12r 296 10 and and CC cord-337849-tyabf12r 296 11 dendritic dendritic JJ cord-337849-tyabf12r 296 12 cell cell NN cord-337849-tyabf12r 296 13 - - HYPH cord-337849-tyabf12r 296 14 induced induce VBN cord-337849-tyabf12r 296 15 T t NN cord-337849-tyabf12r 296 16 cell cell NN cord-337849-tyabf12r 296 17 polarization polarization NN cord-337849-tyabf12r 296 18 Cationic Cationic NNP cord-337849-tyabf12r 296 19 host host NN cord-337849-tyabf12r 296 20 defence defence NN cord-337849-tyabf12r 296 21 peptides peptide NNS cord-337849-tyabf12r 296 22 : : : cord-337849-tyabf12r 296 23 Multifaceted multifaceted JJ cord-337849-tyabf12r 296 24 role role NN cord-337849-tyabf12r 296 25 in in IN cord-337849-tyabf12r 296 26 immune immune JJ cord-337849-tyabf12r 296 27 modulation modulation NN cord-337849-tyabf12r 296 28 and and CC cord-337849-tyabf12r 296 29 inflammation inflammation NN cord-337849-tyabf12r 296 30 Cutting cutting NN cord-337849-tyabf12r 296 31 edge edge NN cord-337849-tyabf12r 297 1 : : : cord-337849-tyabf12r 297 2 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 297 3 D3 D3 NNP cord-337849-tyabf12r 297 4 is be VBZ cord-337849-tyabf12r 297 5 a a DT cord-337849-tyabf12r 297 6 direct direct JJ cord-337849-tyabf12r 297 7 inducer inducer NN cord-337849-tyabf12r 297 8 of of IN cord-337849-tyabf12r 297 9 antimicrobial antimicrobial JJ cord-337849-tyabf12r 297 10 peptide peptide NN cord-337849-tyabf12r 297 11 gene gene NN cord-337849-tyabf12r 297 12 expression expression NN cord-337849-tyabf12r 297 13 Human Human NNP cord-337849-tyabf12r 297 14 cathelicidin cathelicidin NNP cord-337849-tyabf12r 297 15 antimicrobial antimicrobial NN cord-337849-tyabf12r 297 16 peptide peptide NN cord-337849-tyabf12r 297 17 ( ( -LRB- cord-337849-tyabf12r 297 18 CAMP camp NN cord-337849-tyabf12r 297 19 ) ) -RRB- cord-337849-tyabf12r 297 20 gene gene NN cord-337849-tyabf12r 297 21 is be VBZ cord-337849-tyabf12r 297 22 a a DT cord-337849-tyabf12r 297 23 direct direct JJ cord-337849-tyabf12r 297 24 target target NN cord-337849-tyabf12r 297 25 of of IN cord-337849-tyabf12r 297 26 the the DT cord-337849-tyabf12r 297 27 vitamin vitamin NN cord-337849-tyabf12r 297 28 D d NN cord-337849-tyabf12r 297 29 receptor receptor NN cord-337849-tyabf12r 297 30 and and CC cord-337849-tyabf12r 297 31 is be VBZ cord-337849-tyabf12r 297 32 strongly strongly RB cord-337849-tyabf12r 297 33 up up RB cord-337849-tyabf12r 297 34 - - HYPH cord-337849-tyabf12r 297 35 regulated regulate VBN cord-337849-tyabf12r 297 36 in in IN cord-337849-tyabf12r 297 37 myeloid myeloid JJ cord-337849-tyabf12r 297 38 cells cell NNS cord-337849-tyabf12r 297 39 by by IN cord-337849-tyabf12r 297 40 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 297 41 D3 D3 NNP cord-337849-tyabf12r 297 42 Induction Induction NNP cord-337849-tyabf12r 297 43 of of IN cord-337849-tyabf12r 297 44 cathelicidin cathelicidin NNP cord-337849-tyabf12r 297 45 in in IN cord-337849-tyabf12r 297 46 normal normal JJ cord-337849-tyabf12r 297 47 and and CC cord-337849-tyabf12r 297 48 CF cf NN cord-337849-tyabf12r 297 49 bronchial bronchial JJ cord-337849-tyabf12r 297 50 epithelial epithelial JJ cord-337849-tyabf12r 297 51 cells cell NNS cord-337849-tyabf12r 297 52 by by IN cord-337849-tyabf12r 297 53 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 297 54 D(3 d(3 CD cord-337849-tyabf12r 297 55 ) ) -RRB- cord-337849-tyabf12r 298 1 Vitamin vitamin NN cord-337849-tyabf12r 298 2 D d NN cord-337849-tyabf12r 298 3 induces induce VBZ cord-337849-tyabf12r 298 4 the the DT cord-337849-tyabf12r 298 5 antimicrobial antimicrobial JJ cord-337849-tyabf12r 298 6 protein protein NN cord-337849-tyabf12r 298 7 hCAP18 hCAP18 NNP cord-337849-tyabf12r 298 8 in in IN cord-337849-tyabf12r 298 9 human human JJ cord-337849-tyabf12r 298 10 skin skin NN cord-337849-tyabf12r 298 11 Defensins Defensins NNP cord-337849-tyabf12r 298 12 : : : cord-337849-tyabf12r 298 13 Antimicrobial Antimicrobial NNP cord-337849-tyabf12r 298 14 peptides peptide NNS cord-337849-tyabf12r 298 15 of of IN cord-337849-tyabf12r 298 16 innate innate JJ cord-337849-tyabf12r 298 17 immunity immunity NN cord-337849-tyabf12r 298 18 Role role NN cord-337849-tyabf12r 298 19 of of IN cord-337849-tyabf12r 298 20 human human JJ cord-337849-tyabf12r 298 21 beta beta NN cord-337849-tyabf12r 298 22 - - HYPH cord-337849-tyabf12r 298 23 defensin-2 defensin-2 NN cord-337849-tyabf12r 298 24 during during IN cord-337849-tyabf12r 298 25 tumor tumor NN cord-337849-tyabf12r 298 26 necrosis necrosis NN cord-337849-tyabf12r 298 27 factor factor NN cord-337849-tyabf12r 298 28 - - HYPH cord-337849-tyabf12r 298 29 alpha alpha NN cord-337849-tyabf12r 298 30 / / SYM cord-337849-tyabf12r 298 31 NF nf NN cord-337849-tyabf12r 298 32 - - HYPH cord-337849-tyabf12r 298 33 kappaB kappaB NNP cord-337849-tyabf12r 298 34 - - HYPH cord-337849-tyabf12r 298 35 mediated mediate VBN cord-337849-tyabf12r 298 36 innate innate JJ cord-337849-tyabf12r 298 37 antiviral antiviral JJ cord-337849-tyabf12r 298 38 response response NN cord-337849-tyabf12r 298 39 against against IN cord-337849-tyabf12r 298 40 human human JJ cord-337849-tyabf12r 298 41 respiratory respiratory JJ cord-337849-tyabf12r 298 42 syncytial syncytial JJ cord-337849-tyabf12r 298 43 virus virus NN cord-337849-tyabf12r 298 44 Differentiation differentiation NN cord-337849-tyabf12r 298 45 of of IN cord-337849-tyabf12r 298 46 a a DT cord-337849-tyabf12r 298 47 human human JJ cord-337849-tyabf12r 298 48 monocytic monocytic JJ cord-337849-tyabf12r 298 49 cell cell NN cord-337849-tyabf12r 298 50 line line NN cord-337849-tyabf12r 298 51 by by IN cord-337849-tyabf12r 298 52 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 298 53 D3 D3 NNP cord-337849-tyabf12r 298 54 ( ( -LRB- cord-337849-tyabf12r 298 55 calcitriol calcitriol NN cord-337849-tyabf12r 298 56 ) ) -RRB- cord-337849-tyabf12r 298 57 : : : cord-337849-tyabf12r 299 1 A a DT cord-337849-tyabf12r 299 2 morphologic morphologic JJ cord-337849-tyabf12r 299 3 , , , cord-337849-tyabf12r 299 4 phenotypic phenotypic JJ cord-337849-tyabf12r 299 5 , , , cord-337849-tyabf12r 299 6 and and CC cord-337849-tyabf12r 299 7 functional functional JJ cord-337849-tyabf12r 299 8 analysis analysis NN cord-337849-tyabf12r 299 9 25-Dihydroxyvitamin 25-dihydroxyvitamin CD cord-337849-tyabf12r 299 10 D3 D3 NNP cord-337849-tyabf12r 299 11 exerts exert VBZ cord-337849-tyabf12r 299 12 opposing oppose VBG cord-337849-tyabf12r 299 13 effects effect NNS cord-337849-tyabf12r 299 14 to to IN cord-337849-tyabf12r 299 15 IL-4 IL-4 NNP cord-337849-tyabf12r 299 16 on on IN cord-337849-tyabf12r 299 17 MHC MHC NNP cord-337849-tyabf12r 299 18 class class NN cord-337849-tyabf12r 299 19 - - HYPH cord-337849-tyabf12r 299 20 II II NNP cord-337849-tyabf12r 299 21 antigen antigen NN cord-337849-tyabf12r 299 22 expression expression NN cord-337849-tyabf12r 299 23 , , , cord-337849-tyabf12r 299 24 accessory accessory JJ cord-337849-tyabf12r 299 25 activity activity NN cord-337849-tyabf12r 299 26 , , , cord-337849-tyabf12r 299 27 and and CC cord-337849-tyabf12r 299 28 phagocytosis phagocytosis NN cord-337849-tyabf12r 299 29 of of IN cord-337849-tyabf12r 299 30 human human JJ cord-337849-tyabf12r 299 31 monocytes monocyte NNS cord-337849-tyabf12r 299 32 Vitamin vitamin NN cord-337849-tyabf12r 299 33 D d NN cord-337849-tyabf12r 299 34 , , , cord-337849-tyabf12r 299 35 vitamin vitamin NN cord-337849-tyabf12r 299 36 D d NN cord-337849-tyabf12r 299 37 receptor receptor NN cord-337849-tyabf12r 299 38 , , , cord-337849-tyabf12r 299 39 and and CC cord-337849-tyabf12r 299 40 macroautophagy macroautophagy NNS cord-337849-tyabf12r 299 41 in in IN cord-337849-tyabf12r 299 42 inflammation inflammation NN cord-337849-tyabf12r 299 43 and and CC cord-337849-tyabf12r 299 44 infection infection NN cord-337849-tyabf12r 299 45 Reiner Reiner NNP cord-337849-tyabf12r 299 46 , , , cord-337849-tyabf12r 299 47 N. N. NNP cord-337849-tyabf12r 299 48 1alpha,25-Dihydroxyvitamin 1alpha,25-dihydroxyvitamin CD cord-337849-tyabf12r 299 49 D3-induced D3-induced NNP cord-337849-tyabf12r 299 50 monocyte monocyte NNP cord-337849-tyabf12r 299 51 antimycobacterial antimycobacterial JJ cord-337849-tyabf12r 299 52 activity activity NN cord-337849-tyabf12r 299 53 is be VBZ cord-337849-tyabf12r 299 54 regulated regulate VBN cord-337849-tyabf12r 299 55 by by IN cord-337849-tyabf12r 299 56 phosphatidylinositol phosphatidylinositol JJ cord-337849-tyabf12r 299 57 3-kinase 3-kinase CD cord-337849-tyabf12r 299 58 and and CC cord-337849-tyabf12r 299 59 mediated mediate VBN cord-337849-tyabf12r 299 60 by by IN cord-337849-tyabf12r 299 61 the the DT cord-337849-tyabf12r 299 62 NADPH NADPH NNP cord-337849-tyabf12r 299 63 - - HYPH cord-337849-tyabf12r 299 64 dependent dependent JJ cord-337849-tyabf12r 299 65 phagocyte phagocyte NNP cord-337849-tyabf12r 299 66 oxidase oxidase NN cord-337849-tyabf12r 299 67 Reactive reactive JJ cord-337849-tyabf12r 299 68 oxygen oxygen NN cord-337849-tyabf12r 299 69 species specie NNS cord-337849-tyabf12r 299 70 induce induce VBP cord-337849-tyabf12r 299 71 antiviral antiviral JJ cord-337849-tyabf12r 299 72 innate innate JJ cord-337849-tyabf12r 299 73 immune immune JJ cord-337849-tyabf12r 299 74 response response NN cord-337849-tyabf12r 299 75 through through IN cord-337849-tyabf12r 299 76 IFN IFN NNP cord-337849-tyabf12r 299 77 - - HYPH cord-337849-tyabf12r 299 78 λ λ NNP cord-337849-tyabf12r 299 79 regulation regulation NN cord-337849-tyabf12r 299 80 in in IN cord-337849-tyabf12r 299 81 human human JJ cord-337849-tyabf12r 299 82 nasal nasal NN cord-337849-tyabf12r 299 83 epithelial epithelial JJ cord-337849-tyabf12r 299 84 cells cell NNS cord-337849-tyabf12r 299 85 Mucosal Mucosal NNP cord-337849-tyabf12r 299 86 reactive reactive JJ cord-337849-tyabf12r 299 87 oxygen oxygen NN cord-337849-tyabf12r 299 88 species specie NNS cord-337849-tyabf12r 299 89 are be VBP cord-337849-tyabf12r 299 90 required require VBN cord-337849-tyabf12r 299 91 for for IN cord-337849-tyabf12r 299 92 antiviral antiviral JJ cord-337849-tyabf12r 299 93 response response NN cord-337849-tyabf12r 299 94 : : : cord-337849-tyabf12r 300 1 Role role NN cord-337849-tyabf12r 300 2 of of IN cord-337849-tyabf12r 300 3 Duox Duox NNP cord-337849-tyabf12r 300 4 in in IN cord-337849-tyabf12r 300 5 influenza influenza NN cord-337849-tyabf12r 300 6 a a DT cord-337849-tyabf12r 300 7 virus virus NN cord-337849-tyabf12r 300 8 infection infection NN cord-337849-tyabf12r 300 9 Requirement Requirement NNP cord-337849-tyabf12r 300 10 of of IN cord-337849-tyabf12r 300 11 NOX2 NOX2 NNP cord-337849-tyabf12r 300 12 and and CC cord-337849-tyabf12r 300 13 reactive reactive JJ cord-337849-tyabf12r 300 14 oxygen oxygen NN cord-337849-tyabf12r 300 15 species specie NNS cord-337849-tyabf12r 300 16 for for IN cord-337849-tyabf12r 300 17 efficient efficient JJ cord-337849-tyabf12r 300 18 RIG rig NN cord-337849-tyabf12r 300 19 - - HYPH cord-337849-tyabf12r 300 20 I i NN cord-337849-tyabf12r 300 21 - - HYPH cord-337849-tyabf12r 300 22 mediated mediate VBN cord-337849-tyabf12r 300 23 antiviral antiviral JJ cord-337849-tyabf12r 300 24 response response NN cord-337849-tyabf12r 300 25 through through IN cord-337849-tyabf12r 300 26 regulation regulation NN cord-337849-tyabf12r 300 27 of of IN cord-337849-tyabf12r 300 28 MAVS MAVS NNP cord-337849-tyabf12r 300 29 expression expression NN cord-337849-tyabf12r 300 30 IL-15 IL-15 NNP cord-337849-tyabf12r 300 31 induces induce VBZ cord-337849-tyabf12r 300 32 IFN IFN NNP cord-337849-tyabf12r 300 33 - - HYPH cord-337849-tyabf12r 300 34 beta beta NN cord-337849-tyabf12r 300 35 and and CC cord-337849-tyabf12r 300 36 iNOS inos JJ cord-337849-tyabf12r 300 37 gene gene NN cord-337849-tyabf12r 300 38 expression expression NN cord-337849-tyabf12r 300 39 , , , cord-337849-tyabf12r 300 40 and and CC cord-337849-tyabf12r 300 41 antiviral antiviral JJ cord-337849-tyabf12r 300 42 activity activity NN cord-337849-tyabf12r 300 43 of of IN cord-337849-tyabf12r 300 44 murine murine JJ cord-337849-tyabf12r 300 45 macrophage macrophage NN cord-337849-tyabf12r 300 46 RAW raw JJ cord-337849-tyabf12r 300 47 264.7 264.7 CD cord-337849-tyabf12r 300 48 cells cell NNS cord-337849-tyabf12r 300 49 Regulation regulation NN cord-337849-tyabf12r 300 50 of of IN cord-337849-tyabf12r 300 51 the the DT cord-337849-tyabf12r 300 52 expression expression NN cord-337849-tyabf12r 300 53 of of IN cord-337849-tyabf12r 300 54 inducible inducible JJ cord-337849-tyabf12r 300 55 nitric nitric NN cord-337849-tyabf12r 300 56 oxide oxide NN cord-337849-tyabf12r 300 57 synthase synthase NN cord-337849-tyabf12r 300 58 Influenza Influenza NNP cord-337849-tyabf12r 300 59 A a DT cord-337849-tyabf12r 300 60 virus virus NN cord-337849-tyabf12r 300 61 induction induction NN cord-337849-tyabf12r 300 62 of of IN cord-337849-tyabf12r 300 63 oxidative oxidative JJ cord-337849-tyabf12r 300 64 stress stress NN cord-337849-tyabf12r 300 65 and and CC cord-337849-tyabf12r 300 66 MMP-9 MMP-9 NNP cord-337849-tyabf12r 300 67 is be VBZ cord-337849-tyabf12r 300 68 associated associate VBN cord-337849-tyabf12r 300 69 with with IN cord-337849-tyabf12r 300 70 severe severe JJ cord-337849-tyabf12r 300 71 lung lung NN cord-337849-tyabf12r 300 72 pathology pathology NN cord-337849-tyabf12r 300 73 in in IN cord-337849-tyabf12r 300 74 a a DT cord-337849-tyabf12r 300 75 mouse mouse NN cord-337849-tyabf12r 300 76 model model NN cord-337849-tyabf12r 300 77 Downregulation Downregulation NNP cord-337849-tyabf12r 300 78 of of IN cord-337849-tyabf12r 300 79 inducible inducible JJ cord-337849-tyabf12r 300 80 nitric nitric NN cord-337849-tyabf12r 300 81 oxide oxide NN cord-337849-tyabf12r 300 82 synthase synthase NN cord-337849-tyabf12r 301 1 ( ( -LRB- cord-337849-tyabf12r 301 2 iNOS inos JJ cord-337849-tyabf12r 301 3 ) ) -RRB- cord-337849-tyabf12r 301 4 expression expression NN cord-337849-tyabf12r 301 5 is be VBZ cord-337849-tyabf12r 301 6 implicated implicate VBN cord-337849-tyabf12r 301 7 in in IN cord-337849-tyabf12r 301 8 the the DT cord-337849-tyabf12r 301 9 antiviral antiviral JJ cord-337849-tyabf12r 301 10 activity activity NN cord-337849-tyabf12r 301 11 of of IN cord-337849-tyabf12r 301 12 acetylsalicylic acetylsalicylic JJ cord-337849-tyabf12r 301 13 acid acid NN cord-337849-tyabf12r 301 14 in in IN cord-337849-tyabf12r 301 15 HCV HCV NNP cord-337849-tyabf12r 301 16 - - HYPH cord-337849-tyabf12r 301 17 expressing express VBG cord-337849-tyabf12r 301 18 cells cell NNS cord-337849-tyabf12r 302 1 1,25-Dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 303 1 D3 D3 NNP cord-337849-tyabf12r 303 2 induces induce VBZ cord-337849-tyabf12r 303 3 nitric nitric JJ cord-337849-tyabf12r 303 4 oxide oxide NN cord-337849-tyabf12r 303 5 synthase synthase NN cord-337849-tyabf12r 303 6 and and CC cord-337849-tyabf12r 303 7 suppresses suppress VBZ cord-337849-tyabf12r 303 8 growth growth NN cord-337849-tyabf12r 303 9 of of IN cord-337849-tyabf12r 303 10 Mycobacterium Mycobacterium NNP cord-337849-tyabf12r 303 11 tuberculosis tuberculosis NN cord-337849-tyabf12r 303 12 in in IN cord-337849-tyabf12r 303 13 a a DT cord-337849-tyabf12r 303 14 human human JJ cord-337849-tyabf12r 303 15 macrophage macrophage NN cord-337849-tyabf12r 303 16 - - HYPH cord-337849-tyabf12r 303 17 like like JJ cord-337849-tyabf12r 303 18 cell cell NN cord-337849-tyabf12r 303 19 line line NN cord-337849-tyabf12r 303 20 Protective protective JJ cord-337849-tyabf12r 303 21 role role NN cord-337849-tyabf12r 303 22 of of IN cord-337849-tyabf12r 303 23 1 1 CD cord-337849-tyabf12r 303 24 alpha alpha NN cord-337849-tyabf12r 303 25 , , , cord-337849-tyabf12r 303 26 25-dihydroxyvitamin 25-dihydroxyvitamin CD cord-337849-tyabf12r 303 27 D3 D3 NNP cord-337849-tyabf12r 303 28 against against IN cord-337849-tyabf12r 303 29 oxidative oxidative JJ cord-337849-tyabf12r 303 30 stress stress NN cord-337849-tyabf12r 303 31 in in IN cord-337849-tyabf12r 303 32 nonmalignant nonmalignant NNP cord-337849-tyabf12r 303 33 human human JJ cord-337849-tyabf12r 303 34 prostate prostate NN cord-337849-tyabf12r 303 35 epithelial epithelial JJ cord-337849-tyabf12r 303 36 cells cell NNS cord-337849-tyabf12r 303 37 1-alpha,25-Dihydroxyvitamin 1-alpha,25-dihydroxyvitamin CD cord-337849-tyabf12r 303 38 D3 D3 NNP cord-337849-tyabf12r 303 39 regulates regulate VBZ cord-337849-tyabf12r 304 1 inducible inducible JJ cord-337849-tyabf12r 304 2 nitric nitric JJ cord-337849-tyabf12r 304 3 oxide oxide NN cord-337849-tyabf12r 304 4 synthase synthase NN cord-337849-tyabf12r 304 5 messenger messenger NN cord-337849-tyabf12r 304 6 RNA RNA NNP cord-337849-tyabf12r 304 7 expression expression NN cord-337849-tyabf12r 304 8 and and CC cord-337849-tyabf12r 304 9 nitric nitric NN cord-337849-tyabf12r 304 10 oxide oxide NN cord-337849-tyabf12r 304 11 release release NN cord-337849-tyabf12r 304 12 in in IN cord-337849-tyabf12r 304 13 macrophage macrophage NN cord-337849-tyabf12r 304 14 - - HYPH cord-337849-tyabf12r 304 15 like like JJ cord-337849-tyabf12r 304 16 RAW raw JJ cord-337849-tyabf12r 304 17 264.7 264.7 CD cord-337849-tyabf12r 304 18 cells cell NNS cord-337849-tyabf12r 304 19 Vitamin vitamin NN cord-337849-tyabf12r 304 20 D d NN cord-337849-tyabf12r 304 21 : : : cord-337849-tyabf12r 305 1 Oxidative oxidative JJ cord-337849-tyabf12r 305 2 Stress Stress NNP cord-337849-tyabf12r 305 3 , , , cord-337849-tyabf12r 305 4 Immunity Immunity NNP cord-337849-tyabf12r 305 5 , , , cord-337849-tyabf12r 305 6 and and CC cord-337849-tyabf12r 305 7 Aging age VBG cord-337849-tyabf12r 305 8 Autophagy Autophagy NNP cord-337849-tyabf12r 305 9 in in IN cord-337849-tyabf12r 305 10 antiviral antiviral JJ cord-337849-tyabf12r 305 11 innate innate JJ cord-337849-tyabf12r 305 12 immunity immunity NN cord-337849-tyabf12r 305 13 Vitamin vitamin NN cord-337849-tyabf12r 305 14 D3 D3 NNP cord-337849-tyabf12r 305 15 induces induce VBZ cord-337849-tyabf12r 305 16 autophagy autophagy NN cord-337849-tyabf12r 305 17 in in IN cord-337849-tyabf12r 305 18 human human JJ cord-337849-tyabf12r 305 19 monocytes monocyte NNS cord-337849-tyabf12r 305 20 / / SYM cord-337849-tyabf12r 305 21 macrophages macrophage NNS cord-337849-tyabf12r 305 22 via via IN cord-337849-tyabf12r 305 23 cathelicidin cathelicidin NNP cord-337849-tyabf12r 305 24 Autophagy Autophagy NNP cord-337849-tyabf12r 305 25 as as IN cord-337849-tyabf12r 305 26 a a DT cord-337849-tyabf12r 305 27 basis basis NN cord-337849-tyabf12r 305 28 for for IN cord-337849-tyabf12r 305 29 the the DT cord-337849-tyabf12r 305 30 health health NN cord-337849-tyabf12r 305 31 - - HYPH cord-337849-tyabf12r 305 32 promoting promote VBG cord-337849-tyabf12r 305 33 effects effect NNS cord-337849-tyabf12r 305 34 of of IN cord-337849-tyabf12r 305 35 vitamin vitamin NN cord-337849-tyabf12r 305 36 D d NN cord-337849-tyabf12r 305 37 Vitamin vitamin NN cord-337849-tyabf12r 305 38 D3 D3 NNP cord-337849-tyabf12r 305 39 down down RB cord-337849-tyabf12r 305 40 - - HYPH cord-337849-tyabf12r 305 41 regulates regulate VBZ cord-337849-tyabf12r 305 42 monocyte monocyte NNP cord-337849-tyabf12r 305 43 TLR TLR NNP cord-337849-tyabf12r 305 44 expression expression NN cord-337849-tyabf12r 305 45 and and CC cord-337849-tyabf12r 305 46 triggers trigger VBZ cord-337849-tyabf12r 305 47 hyporesponsiveness hyporesponsiveness NN cord-337849-tyabf12r 305 48 to to IN cord-337849-tyabf12r 305 49 pathogen pathogen NN cord-337849-tyabf12r 305 50 - - HYPH cord-337849-tyabf12r 305 51 associated associate VBN cord-337849-tyabf12r 305 52 molecular molecular JJ cord-337849-tyabf12r 305 53 patterns pattern NNS cord-337849-tyabf12r 305 54 Binding bind VBG cord-337849-tyabf12r 305 55 of of IN cord-337849-tyabf12r 305 56 lipopeptide lipopeptide NN cord-337849-tyabf12r 305 57 to to IN cord-337849-tyabf12r 305 58 CD14 CD14 NNP cord-337849-tyabf12r 305 59 induces induce VBZ cord-337849-tyabf12r 305 60 physical physical JJ cord-337849-tyabf12r 305 61 proximity proximity NN cord-337849-tyabf12r 305 62 of of IN cord-337849-tyabf12r 305 63 CD14 CD14 NNP cord-337849-tyabf12r 305 64 , , , cord-337849-tyabf12r 305 65 TLR2 TLR2 NNP cord-337849-tyabf12r 305 66 and and CC cord-337849-tyabf12r 305 67 TLR1 TLR1 NNP cord-337849-tyabf12r 305 68 Functional functional JJ cord-337849-tyabf12r 305 69 antagonism antagonism NN cord-337849-tyabf12r 305 70 between between IN cord-337849-tyabf12r 305 71 vitamin vitamin NN cord-337849-tyabf12r 305 72 D3 D3 NNP cord-337849-tyabf12r 305 73 and and CC cord-337849-tyabf12r 305 74 retinoic retinoic JJ cord-337849-tyabf12r 305 75 acid acid NN cord-337849-tyabf12r 305 76 in in IN cord-337849-tyabf12r 305 77 the the DT cord-337849-tyabf12r 305 78 regulation regulation NN cord-337849-tyabf12r 305 79 of of IN cord-337849-tyabf12r 305 80 CD14 CD14 NNP cord-337849-tyabf12r 305 81 and and CC cord-337849-tyabf12r 305 82 CD23 CD23 NNP cord-337849-tyabf12r 305 83 expression expression NN cord-337849-tyabf12r 305 84 during during IN cord-337849-tyabf12r 305 85 monocytic monocytic JJ cord-337849-tyabf12r 305 86 differentiation differentiation NN cord-337849-tyabf12r 305 87 of of IN cord-337849-tyabf12r 305 88 U-937 u-937 NN cord-337849-tyabf12r 305 89 cells cell NNS cord-337849-tyabf12r 305 90 Regulation regulation NN cord-337849-tyabf12r 305 91 of of IN cord-337849-tyabf12r 305 92 CD14 CD14 NNP cord-337849-tyabf12r 305 93 expression expression NN cord-337849-tyabf12r 305 94 during during IN cord-337849-tyabf12r 305 95 monocytic monocytic JJ cord-337849-tyabf12r 305 96 differentiation differentiation NN cord-337849-tyabf12r 305 97 induced induce VBN cord-337849-tyabf12r 305 98 with with IN cord-337849-tyabf12r 305 99 1 1 CD cord-337849-tyabf12r 305 100 alpha,25-dihydroxyvitamin alpha,25-dihydroxyvitamin CD cord-337849-tyabf12r 305 101 D3 D3 NNP cord-337849-tyabf12r 305 102 Injury Injury NNP cord-337849-tyabf12r 305 103 enhances enhance VBZ cord-337849-tyabf12r 305 104 TLR2 TLR2 NNP cord-337849-tyabf12r 305 105 function function NN cord-337849-tyabf12r 305 106 and and CC cord-337849-tyabf12r 305 107 antimicrobial antimicrobial JJ cord-337849-tyabf12r 305 108 peptide peptide JJ cord-337849-tyabf12r 305 109 expression expression NN cord-337849-tyabf12r 305 110 through through IN cord-337849-tyabf12r 305 111 a a DT cord-337849-tyabf12r 305 112 vitamin vitamin NN cord-337849-tyabf12r 305 113 D d NN cord-337849-tyabf12r 305 114 - - HYPH cord-337849-tyabf12r 305 115 dependent dependent JJ cord-337849-tyabf12r 305 116 mechanism mechanism NN cord-337849-tyabf12r 306 1 Direct direct JJ cord-337849-tyabf12r 306 2 and and CC cord-337849-tyabf12r 306 3 indirect indirect JJ cord-337849-tyabf12r 306 4 induction induction NN cord-337849-tyabf12r 306 5 by by IN cord-337849-tyabf12r 306 6 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 306 7 D3 D3 NNP cord-337849-tyabf12r 306 8 of of IN cord-337849-tyabf12r 306 9 the the DT cord-337849-tyabf12r 306 10 NOD2 NOD2 NNPS cord-337849-tyabf12r 306 11 / / SYM cord-337849-tyabf12r 306 12 CARD15-defensin CARD15-defensin NNP cord-337849-tyabf12r 306 13 beta2 beta2 NN cord-337849-tyabf12r 306 14 innate innate VBP cord-337849-tyabf12r 306 15 immune immune JJ cord-337849-tyabf12r 306 16 pathway pathway NN cord-337849-tyabf12r 306 17 defective defective JJ cord-337849-tyabf12r 306 18 in in IN cord-337849-tyabf12r 306 19 Crohn Crohn NNP cord-337849-tyabf12r 306 20 disease disease NN cord-337849-tyabf12r 306 21 1 1 CD cord-337849-tyabf12r 307 1 Alpha,25-dihydroxyvitamin Alpha,25-dihydroxyvitamin NNP cord-337849-tyabf12r 307 2 D3 D3 NNP cord-337849-tyabf12r 307 3 inhibits inhibit VBZ cord-337849-tyabf12r 307 4 differentiation differentiation NN cord-337849-tyabf12r 307 5 , , , cord-337849-tyabf12r 307 6 maturation maturation NN cord-337849-tyabf12r 307 7 , , , cord-337849-tyabf12r 307 8 activation activation NN cord-337849-tyabf12r 307 9 , , , cord-337849-tyabf12r 307 10 and and CC cord-337849-tyabf12r 307 11 survival survival NN cord-337849-tyabf12r 307 12 of of IN cord-337849-tyabf12r 307 13 dendritic dendritic JJ cord-337849-tyabf12r 307 14 cells cell NNS cord-337849-tyabf12r 307 15 leading lead VBG cord-337849-tyabf12r 307 16 to to IN cord-337849-tyabf12r 307 17 impaired impaired JJ cord-337849-tyabf12r 307 18 alloreactive alloreactive NNP cord-337849-tyabf12r 307 19 T T NNP cord-337849-tyabf12r 307 20 cell cell NN cord-337849-tyabf12r 307 21 activation activation NN cord-337849-tyabf12r 307 22 1,25-Dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 307 23 D(3 D(3 NNS cord-337849-tyabf12r 307 24 ) ) -RRB- cord-337849-tyabf12r 307 25 inhibits inhibit VBZ cord-337849-tyabf12r 307 26 dendritic dendritic JJ cord-337849-tyabf12r 307 27 cell cell NN cord-337849-tyabf12r 307 28 differentiation differentiation NN cord-337849-tyabf12r 307 29 and and CC cord-337849-tyabf12r 307 30 maturation maturation NN cord-337849-tyabf12r 307 31 in in IN cord-337849-tyabf12r 307 32 vitro vitro FW cord-337849-tyabf12r 308 1 The the DT cord-337849-tyabf12r 308 2 vitamin vitamin NN cord-337849-tyabf12r 308 3 D3 D3 NNP cord-337849-tyabf12r 308 4 analog analog NN cord-337849-tyabf12r 308 5 calcipotriol calcipotriol NNP cord-337849-tyabf12r 308 6 suppresses suppress VBZ cord-337849-tyabf12r 308 7 the the DT cord-337849-tyabf12r 308 8 number number NN cord-337849-tyabf12r 308 9 and and CC cord-337849-tyabf12r 308 10 antigen antigen NN cord-337849-tyabf12r 308 11 - - HYPH cord-337849-tyabf12r 308 12 presenting present VBG cord-337849-tyabf12r 308 13 function function NN cord-337849-tyabf12r 308 14 of of IN cord-337849-tyabf12r 308 15 Langerhans Langerhans NNP cord-337849-tyabf12r 308 16 cells cell NNS cord-337849-tyabf12r 308 17 in in IN cord-337849-tyabf12r 308 18 normal normal JJ cord-337849-tyabf12r 308 19 human human JJ cord-337849-tyabf12r 308 20 skin skin NN cord-337849-tyabf12r 308 21 Suppressive suppressive JJ cord-337849-tyabf12r 308 22 effect effect NN cord-337849-tyabf12r 308 23 of of IN cord-337849-tyabf12r 308 24 1alpha,25-dihydroxyvitamin 1alpha,25-dihydroxyvitamin CD cord-337849-tyabf12r 308 25 D3 D3 NNP cord-337849-tyabf12r 308 26 on on IN cord-337849-tyabf12r 308 27 type type NN cord-337849-tyabf12r 309 1 I -PRON- PRP cord-337849-tyabf12r 309 2 IFN IFN NNP cord-337849-tyabf12r 309 3 - - HYPH cord-337849-tyabf12r 309 4 mediated mediate VBN cord-337849-tyabf12r 309 5 monocyte monocyte JJ cord-337849-tyabf12r 309 6 differentiation differentiation NN cord-337849-tyabf12r 309 7 into into IN cord-337849-tyabf12r 309 8 dendritic dendritic JJ cord-337849-tyabf12r 309 9 cells cell NNS cord-337849-tyabf12r 309 10 : : : cord-337849-tyabf12r 309 11 Impairment impairment NN cord-337849-tyabf12r 309 12 of of IN cord-337849-tyabf12r 309 13 functional functional JJ cord-337849-tyabf12r 309 14 activities activity NNS cord-337849-tyabf12r 309 15 and and CC cord-337849-tyabf12r 309 16 chemotaxis chemotaxis NN cord-337849-tyabf12r 309 17 Vitamin vitamin NN cord-337849-tyabf12r 309 18 D3 D3 NNP cord-337849-tyabf12r 309 19 and and CC cord-337849-tyabf12r 309 20 the the DT cord-337849-tyabf12r 309 21 immune immune JJ cord-337849-tyabf12r 309 22 system system NN cord-337849-tyabf12r 309 23 : : : cord-337849-tyabf12r 309 24 Maintaining maintain VBG cord-337849-tyabf12r 309 25 the the DT cord-337849-tyabf12r 309 26 balance balance NN cord-337849-tyabf12r 309 27 in in IN cord-337849-tyabf12r 309 28 health health NN cord-337849-tyabf12r 309 29 and and CC cord-337849-tyabf12r 309 30 disease disease NN cord-337849-tyabf12r 309 31 Panina Panina NNP cord-337849-tyabf12r 309 32 - - HYPH cord-337849-tyabf12r 309 33 Bordignon Bordignon NNP cord-337849-tyabf12r 309 34 , , , cord-337849-tyabf12r 309 35 P. P. NNP cord-337849-tyabf12r 309 36 Inhibition inhibition NN cord-337849-tyabf12r 309 37 of of IN cord-337849-tyabf12r 309 38 IL-12 IL-12 NNP cord-337849-tyabf12r 309 39 production production NN cord-337849-tyabf12r 309 40 by by IN cord-337849-tyabf12r 309 41 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 309 42 D3 D3 NNP cord-337849-tyabf12r 309 43 . . . cord-337849-tyabf12r 310 1 Involvement involvement NN cord-337849-tyabf12r 310 2 of of IN cord-337849-tyabf12r 310 3 NF NF NNP cord-337849-tyabf12r 310 4 - - HYPH cord-337849-tyabf12r 310 5 kappaB kappaB NNP cord-337849-tyabf12r 310 6 downregulation downregulation NN cord-337849-tyabf12r 310 7 in in IN cord-337849-tyabf12r 310 8 transcriptional transcriptional JJ cord-337849-tyabf12r 310 9 repression repression NN cord-337849-tyabf12r 310 10 of of IN cord-337849-tyabf12r 310 11 the the DT cord-337849-tyabf12r 310 12 p40 p40 CD cord-337849-tyabf12r 310 13 gene gene NN cord-337849-tyabf12r 310 14 ) ) -RRB- cord-337849-tyabf12r 311 1 dose dose NN cord-337849-tyabf12r 311 2 - - : cord-337849-tyabf12r 311 3 dependently dependently RB cord-337849-tyabf12r 311 4 inhibits inhibit VBZ cord-337849-tyabf12r 311 5 LPS LPS NNP cord-337849-tyabf12r 311 6 - - HYPH cord-337849-tyabf12r 311 7 induced induce VBN cord-337849-tyabf12r 311 8 cytokines cytokine NNS cord-337849-tyabf12r 311 9 production production NN cord-337849-tyabf12r 311 10 in in IN cord-337849-tyabf12r 311 11 PBMC PBMC NNS cord-337849-tyabf12r 311 12 modulating modulate VBG cord-337849-tyabf12r 311 13 intracellular intracellular JJ cord-337849-tyabf12r 311 14 calcium calcium NN cord-337849-tyabf12r 311 15 Redirection redirection NN cord-337849-tyabf12r 311 16 of of IN cord-337849-tyabf12r 311 17 human human JJ cord-337849-tyabf12r 311 18 autoreactive autoreactive JJ cord-337849-tyabf12r 311 19 T T NNP cord-337849-tyabf12r 311 20 - - HYPH cord-337849-tyabf12r 311 21 cells cell NNS cord-337849-tyabf12r 311 22 upon upon IN cord-337849-tyabf12r 311 23 interaction interaction NN cord-337849-tyabf12r 311 24 with with IN cord-337849-tyabf12r 311 25 dendritic dendritic JJ cord-337849-tyabf12r 311 26 cells cell NNS cord-337849-tyabf12r 311 27 modulated modulate VBN cord-337849-tyabf12r 311 28 by by IN cord-337849-tyabf12r 311 29 TX527 TX527 NNP cord-337849-tyabf12r 311 30 , , , cord-337849-tyabf12r 311 31 an an DT cord-337849-tyabf12r 311 32 analog analog NN cord-337849-tyabf12r 311 33 of of IN cord-337849-tyabf12r 311 34 1 1 CD cord-337849-tyabf12r 311 35 Immunosuppressive immunosuppressive JJ cord-337849-tyabf12r 311 36 actions action NNS cord-337849-tyabf12r 311 37 of of IN cord-337849-tyabf12r 311 38 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 311 39 D3 D3 NNP cord-337849-tyabf12r 311 40 : : : cord-337849-tyabf12r 312 1 Preferential preferential JJ cord-337849-tyabf12r 312 2 inhibition inhibition NN cord-337849-tyabf12r 312 3 of of IN cord-337849-tyabf12r 312 4 Th1 th1 NN cord-337849-tyabf12r 312 5 functions function NNS cord-337849-tyabf12r 312 6 Reversing reverse VBG cord-337849-tyabf12r 312 7 the the DT cord-337849-tyabf12r 312 8 defective defective JJ cord-337849-tyabf12r 312 9 induction induction NN cord-337849-tyabf12r 312 10 of of IN cord-337849-tyabf12r 312 11 IL-10-secreting il-10-secrete VBG cord-337849-tyabf12r 312 12 regulatory regulatory JJ cord-337849-tyabf12r 312 13 T t NN cord-337849-tyabf12r 312 14 cells cell NNS cord-337849-tyabf12r 312 15 in in IN cord-337849-tyabf12r 312 16 glucocorticoid glucocorticoid NN cord-337849-tyabf12r 312 17 - - HYPH cord-337849-tyabf12r 312 18 resistant resistant JJ cord-337849-tyabf12r 312 19 asthma asthma NN cord-337849-tyabf12r 312 20 patients patient NNS cord-337849-tyabf12r 313 1 Interleukin-10 interleukin-10 NN cord-337849-tyabf12r 313 2 regulation regulation NN cord-337849-tyabf12r 313 3 in in IN cord-337849-tyabf12r 313 4 normal normal JJ cord-337849-tyabf12r 313 5 subjects subject NNS cord-337849-tyabf12r 313 6 and and CC cord-337849-tyabf12r 313 7 patients patient NNS cord-337849-tyabf12r 313 8 with with IN cord-337849-tyabf12r 313 9 asthma asthma NN cord-337849-tyabf12r 313 10 Calcitriol Calcitriol NNP cord-337849-tyabf12r 313 11 suppresses suppress VBZ cord-337849-tyabf12r 313 12 antiretinal antiretinal JJ cord-337849-tyabf12r 313 13 autoimmunity autoimmunity NN cord-337849-tyabf12r 313 14 through through IN cord-337849-tyabf12r 313 15 inhibitory inhibitory JJ cord-337849-tyabf12r 313 16 effects effect NNS cord-337849-tyabf12r 313 17 on on IN cord-337849-tyabf12r 313 18 the the DT cord-337849-tyabf12r 313 19 Th17 Th17 NNP cord-337849-tyabf12r 313 20 effector effector NN cord-337849-tyabf12r 313 21 response response NN cord-337849-tyabf12r 313 22 Immune immune JJ cord-337849-tyabf12r 313 23 modulatory modulatory JJ cord-337849-tyabf12r 313 24 treatment treatment NN cord-337849-tyabf12r 313 25 of of IN cord-337849-tyabf12r 313 26 trinitrobenzene trinitrobenzene NNP cord-337849-tyabf12r 313 27 sulfonic sulfonic JJ cord-337849-tyabf12r 313 28 acid acid NN cord-337849-tyabf12r 313 29 colitis colitis NN cord-337849-tyabf12r 313 30 with with IN cord-337849-tyabf12r 313 31 calcitriol calcitriol NNP cord-337849-tyabf12r 313 32 is be VBZ cord-337849-tyabf12r 313 33 associated associate VBN cord-337849-tyabf12r 313 34 with with IN cord-337849-tyabf12r 313 35 a a DT cord-337849-tyabf12r 313 36 change change NN cord-337849-tyabf12r 313 37 of of IN cord-337849-tyabf12r 313 38 a a DT cord-337849-tyabf12r 313 39 T T NNP cord-337849-tyabf12r 313 40 helper helper NN cord-337849-tyabf12r 313 41 Th17 th17 NN cord-337849-tyabf12r 313 42 to to IN cord-337849-tyabf12r 313 43 a a DT cord-337849-tyabf12r 313 44 Th2 th2 CD cord-337849-tyabf12r 313 45 and and CC cord-337849-tyabf12r 313 46 regulatory regulatory JJ cord-337849-tyabf12r 313 47 T T NNP cord-337849-tyabf12r 313 48 cell cell NN cord-337849-tyabf12r 313 49 profile profile NN cord-337849-tyabf12r 314 1 Interleukin-17 interleukin-17 IN cord-337849-tyabf12r 314 2 and and CC cord-337849-tyabf12r 314 3 type type VB cord-337849-tyabf12r 314 4 17 17 CD cord-337849-tyabf12r 314 5 helper helper NN cord-337849-tyabf12r 314 6 T t NN cord-337849-tyabf12r 314 7 cells cell NNS cord-337849-tyabf12r 314 8 Deficiency deficiency NN cord-337849-tyabf12r 314 9 of of IN cord-337849-tyabf12r 314 10 Th17 Th17 NNP cord-337849-tyabf12r 314 11 cells cell NNS cord-337849-tyabf12r 314 12 in in IN cord-337849-tyabf12r 314 13 hyper hyper NNP cord-337849-tyabf12r 314 14 IgE IgE NNP cord-337849-tyabf12r 314 15 syndrome syndrome NN cord-337849-tyabf12r 314 16 due due IN cord-337849-tyabf12r 314 17 to to IN cord-337849-tyabf12r 314 18 mutations mutation NNS cord-337849-tyabf12r 314 19 in in IN cord-337849-tyabf12r 314 20 STAT3 STAT3 NNP cord-337849-tyabf12r 315 1 In in IN cord-337849-tyabf12r 315 2 vitro vitro FW cord-337849-tyabf12r 315 3 generation generation NN cord-337849-tyabf12r 315 4 of of IN cord-337849-tyabf12r 315 5 interleukin interleukin NN cord-337849-tyabf12r 315 6 10-producing 10-producing CD cord-337849-tyabf12r 315 7 regulatory regulatory JJ cord-337849-tyabf12r 315 8 CD4(+ CD4(+ NNP cord-337849-tyabf12r 315 9 ) ) -RRB- cord-337849-tyabf12r 315 10 T t NN cord-337849-tyabf12r 315 11 cells cell NNS cord-337849-tyabf12r 315 12 is be VBZ cord-337849-tyabf12r 315 13 induced induce VBN cord-337849-tyabf12r 315 14 by by IN cord-337849-tyabf12r 315 15 immunosuppressive immunosuppressive JJ cord-337849-tyabf12r 315 16 drugs drug NNS cord-337849-tyabf12r 315 17 and and CC cord-337849-tyabf12r 315 18 inhibited inhibit VBN cord-337849-tyabf12r 315 19 by by IN cord-337849-tyabf12r 315 20 T T NNP cord-337849-tyabf12r 315 21 helper helper NN cord-337849-tyabf12r 315 22 type type NN cord-337849-tyabf12r 315 23 1 1 CD cord-337849-tyabf12r 316 1 ( ( -LRB- cord-337849-tyabf12r 316 2 Th1)-and th1)-and CD cord-337849-tyabf12r 316 3 Th2-inducing th2-induce VBG cord-337849-tyabf12r 316 4 cytokines cytokine NNS cord-337849-tyabf12r 316 5 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 316 6 D3 D3 NNP cord-337849-tyabf12r 316 7 and and CC cord-337849-tyabf12r 317 1 IL-2 IL-2 NNP cord-337849-tyabf12r 317 2 combine combine VBP cord-337849-tyabf12r 317 3 to to TO cord-337849-tyabf12r 317 4 inhibit inhibit VB cord-337849-tyabf12r 317 5 T t NN cord-337849-tyabf12r 317 6 cell cell NN cord-337849-tyabf12r 317 7 production production NN cord-337849-tyabf12r 317 8 of of IN cord-337849-tyabf12r 317 9 inflammatory inflammatory JJ cord-337849-tyabf12r 317 10 cytokines cytokine NNS cord-337849-tyabf12r 317 11 and and CC cord-337849-tyabf12r 317 12 promote promote VB cord-337849-tyabf12r 317 13 development development NN cord-337849-tyabf12r 317 14 of of IN cord-337849-tyabf12r 317 15 regulatory regulatory JJ cord-337849-tyabf12r 317 16 T t NN cord-337849-tyabf12r 317 17 cells cell NNS cord-337849-tyabf12r 317 18 expressing express VBG cord-337849-tyabf12r 317 19 CTLA-4 CTLA-4 NNPS cord-337849-tyabf12r 317 20 and and CC cord-337849-tyabf12r 317 21 FoxP3 FoxP3 NNP cord-337849-tyabf12r 317 22 Regulation Regulation NNP cord-337849-tyabf12r 317 23 of of IN cord-337849-tyabf12r 317 24 lymphokine lymphokine NN cord-337849-tyabf12r 317 25 production production NN cord-337849-tyabf12r 317 26 and and CC cord-337849-tyabf12r 317 27 human human JJ cord-337849-tyabf12r 317 28 T T NNP cord-337849-tyabf12r 317 29 lymphocyte lymphocyte NN cord-337849-tyabf12r 317 30 activation activation NN cord-337849-tyabf12r 317 31 by by IN cord-337849-tyabf12r 317 32 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 317 33 D3 D3 NNP cord-337849-tyabf12r 317 34 . . . cord-337849-tyabf12r 318 1 Specific specific JJ cord-337849-tyabf12r 318 2 inhibition inhibition NN cord-337849-tyabf12r 318 3 at at IN cord-337849-tyabf12r 318 4 the the DT cord-337849-tyabf12r 318 5 level level NN cord-337849-tyabf12r 318 6 of of IN cord-337849-tyabf12r 318 7 messenger messenger NN cord-337849-tyabf12r 318 8 RNA RNA NNP cord-337849-tyabf12r 318 9 Vitamin vitamin NN cord-337849-tyabf12r 318 10 D3 D3 NNP cord-337849-tyabf12r 318 11 : : : cord-337849-tyabf12r 319 1 A a DT cord-337849-tyabf12r 319 2 transcriptional transcriptional JJ cord-337849-tyabf12r 319 3 modulator modulator NN cord-337849-tyabf12r 319 4 of of IN cord-337849-tyabf12r 319 5 the the DT cord-337849-tyabf12r 319 6 interferon interferon NN cord-337849-tyabf12r 319 7 - - HYPH cord-337849-tyabf12r 319 8 gamma gamma NN cord-337849-tyabf12r 319 9 gene gene NN cord-337849-tyabf12r 320 1 25-dihydroxyvitamin 25-dihydroxyvitamin CD cord-337849-tyabf12r 320 2 d3 d3 NNP cord-337849-tyabf12r 320 3 has have VBZ cord-337849-tyabf12r 320 4 a a DT cord-337849-tyabf12r 320 5 direct direct JJ cord-337849-tyabf12r 320 6 effect effect NN cord-337849-tyabf12r 320 7 on on IN cord-337849-tyabf12r 320 8 naive naive JJ cord-337849-tyabf12r 320 9 CD4(+ CD4(+ NNS cord-337849-tyabf12r 320 10 ) ) -RRB- cord-337849-tyabf12r 321 1 T T NNP cord-337849-tyabf12r 321 2 cells cell NNS cord-337849-tyabf12r 321 3 to to TO cord-337849-tyabf12r 321 4 enhance enhance VB cord-337849-tyabf12r 321 5 the the DT cord-337849-tyabf12r 321 6 development development NN cord-337849-tyabf12r 321 7 of of IN cord-337849-tyabf12r 321 8 Th2 th2 CD cord-337849-tyabf12r 321 9 cells cell NNS cord-337849-tyabf12r 321 10 Regulatory Regulatory NNP cord-337849-tyabf12r 321 11 B B NNP cord-337849-tyabf12r 321 12 cells cell NNS cord-337849-tyabf12r 321 13 in in IN cord-337849-tyabf12r 321 14 autoimmune autoimmune JJ cord-337849-tyabf12r 321 15 diseases disease NNS cord-337849-tyabf12r 321 16 Restoration Restoration NNP cord-337849-tyabf12r 321 17 of of IN cord-337849-tyabf12r 321 18 regulatory regulatory JJ cord-337849-tyabf12r 321 19 and and CC cord-337849-tyabf12r 321 20 effector effector JJ cord-337849-tyabf12r 321 21 T T NNP cord-337849-tyabf12r 321 22 cell cell NN cord-337849-tyabf12r 321 23 balance balance NN cord-337849-tyabf12r 321 24 and and CC cord-337849-tyabf12r 321 25 B b NN cord-337849-tyabf12r 321 26 cell cell NN cord-337849-tyabf12r 321 27 homeostasis homeostasis NN cord-337849-tyabf12r 321 28 in in IN cord-337849-tyabf12r 321 29 systemic systemic JJ cord-337849-tyabf12r 321 30 lupus lupus NN cord-337849-tyabf12r 321 31 erythematosus erythematosus NN cord-337849-tyabf12r 321 32 patients patient NNS cord-337849-tyabf12r 321 33 through through IN cord-337849-tyabf12r 321 34 vitamin vitamin NN cord-337849-tyabf12r 321 35 D d NN cord-337849-tyabf12r 321 36 supplementation supplementation NN cord-337849-tyabf12r 321 37 Vitamin vitamin NN cord-337849-tyabf12r 321 38 D d NN cord-337849-tyabf12r 321 39 , , , cord-337849-tyabf12r 321 40 invariant invariant JJ cord-337849-tyabf12r 321 41 natural natural JJ cord-337849-tyabf12r 321 42 killer killer NN cord-337849-tyabf12r 321 43 T t NN cord-337849-tyabf12r 321 44 - - HYPH cord-337849-tyabf12r 321 45 cells cell NNS cord-337849-tyabf12r 321 46 and and CC cord-337849-tyabf12r 321 47 experimental experimental JJ cord-337849-tyabf12r 321 48 autoimmune autoimmune JJ cord-337849-tyabf12r 321 49 disease disease NN cord-337849-tyabf12r 322 1 Vitamin vitamin NN cord-337849-tyabf12r 322 2 D d NN cord-337849-tyabf12r 322 3 has have VBZ cord-337849-tyabf12r 322 4 a a DT cord-337849-tyabf12r 322 5 direct direct JJ cord-337849-tyabf12r 322 6 immunomodulatory immunomodulatory JJ cord-337849-tyabf12r 322 7 effect effect NN cord-337849-tyabf12r 322 8 on on IN cord-337849-tyabf12r 322 9 CD8 CD8 NNP cord-337849-tyabf12r 322 10 + + CC cord-337849-tyabf12r 322 11 T T NNP cord-337849-tyabf12r 322 12 cells cell NNS cord-337849-tyabf12r 322 13 of of IN cord-337849-tyabf12r 322 14 patients patient NNS cord-337849-tyabf12r 322 15 with with IN cord-337849-tyabf12r 322 16 early early JJ cord-337849-tyabf12r 322 17 multiple multiple JJ cord-337849-tyabf12r 322 18 sclerosis sclerosis NN cord-337849-tyabf12r 322 19 and and CC cord-337849-tyabf12r 322 20 healthy healthy JJ cord-337849-tyabf12r 322 21 control control NN cord-337849-tyabf12r 322 22 subjects subject NNS cord-337849-tyabf12r 323 1 The the DT cord-337849-tyabf12r 323 2 anti anti JJ cord-337849-tyabf12r 323 3 - - JJ cord-337849-tyabf12r 323 4 inflammatory inflammatory JJ cord-337849-tyabf12r 323 5 effects effect NNS cord-337849-tyabf12r 323 6 of of IN cord-337849-tyabf12r 323 7 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 323 8 D3 D3 NNP cord-337849-tyabf12r 323 9 on on IN cord-337849-tyabf12r 323 10 Th2 th2 CD cord-337849-tyabf12r 323 11 cells cell NNS cord-337849-tyabf12r 323 12 in in IN cord-337849-tyabf12r 323 13 vivo vivo NN cord-337849-tyabf12r 323 14 are be VBP cord-337849-tyabf12r 323 15 due due JJ cord-337849-tyabf12r 323 16 in in IN cord-337849-tyabf12r 323 17 part part NN cord-337849-tyabf12r 323 18 to to IN cord-337849-tyabf12r 323 19 the the DT cord-337849-tyabf12r 323 20 control control NN cord-337849-tyabf12r 323 21 of of IN cord-337849-tyabf12r 323 22 integrin integrin NN cord-337849-tyabf12r 323 23 - - HYPH cord-337849-tyabf12r 323 24 mediated mediate VBN cord-337849-tyabf12r 323 25 T t NN cord-337849-tyabf12r 323 26 lymphocyte lymphocyte NN cord-337849-tyabf12r 323 27 homing homing NN cord-337849-tyabf12r 323 28 Issazadeh Issazadeh NNP cord-337849-tyabf12r 323 29 - - HYPH cord-337849-tyabf12r 323 30 Navikas Navikas NNP cord-337849-tyabf12r 323 31 , , , cord-337849-tyabf12r 323 32 S. S. NNP cord-337849-tyabf12r 323 33 Dual dual JJ cord-337849-tyabf12r 323 34 effects effect NNS cord-337849-tyabf12r 323 35 of of IN cord-337849-tyabf12r 323 36 vitamin vitamin NN cord-337849-tyabf12r 323 37 D d NN cord-337849-tyabf12r 323 38 - - HYPH cord-337849-tyabf12r 323 39 induced induce VBN cord-337849-tyabf12r 323 40 alteration alteration NN cord-337849-tyabf12r 323 41 of of IN cord-337849-tyabf12r 323 42 TH1 TH1 NNP cord-337849-tyabf12r 323 43 / / SYM cord-337849-tyabf12r 323 44 TH2 TH2 NNP cord-337849-tyabf12r 323 45 cytokine cytokine NN cord-337849-tyabf12r 323 46 expression expression NN cord-337849-tyabf12r 323 47 : : : cord-337849-tyabf12r 324 1 Enhancing enhance VBG cord-337849-tyabf12r 324 2 IgE IgE NNP cord-337849-tyabf12r 324 3 production production NN cord-337849-tyabf12r 324 4 and and CC cord-337849-tyabf12r 324 5 decreasing decrease VBG cord-337849-tyabf12r 324 6 airway airway NN cord-337849-tyabf12r 324 7 eosinophilia eosinophilia NN cord-337849-tyabf12r 324 8 in in IN cord-337849-tyabf12r 324 9 murine murine JJ cord-337849-tyabf12r 324 10 allergic allergic JJ cord-337849-tyabf12r 324 11 airway airway NN cord-337849-tyabf12r 324 12 disease disease NN cord-337849-tyabf12r 324 13 1,25-dihydroxyvitamin 1,25-dihydroxyvitamin CD cord-337849-tyabf12r 324 14 D3 D3 NNP cord-337849-tyabf12r 324 15 inhibits inhibit VBZ cord-337849-tyabf12r 324 16 IFN IFN NNP cord-337849-tyabf12r 324 17 - - HYPH cord-337849-tyabf12r 324 18 gamma gamma NN cord-337849-tyabf12r 324 19 and and CC cord-337849-tyabf12r 324 20 IL-4 IL-4 NNP cord-337849-tyabf12r 324 21 levels level NNS cord-337849-tyabf12r 324 22 in in IN cord-337849-tyabf12r 324 23 vitro vitro FW cord-337849-tyabf12r 324 24 polaization polaization NN cord-337849-tyabf12r 324 25 of of IN cord-337849-tyabf12r 324 26 primary primary JJ cord-337849-tyabf12r 324 27 murine murine JJ cord-337849-tyabf12r 324 28 CD4 CD4 NNP cord-337849-tyabf12r 324 29 + + CC cord-337849-tyabf12r 324 30 T t NN cord-337849-tyabf12r 324 31 cells cell NNS cord-337849-tyabf12r 324 32 Vitamin vitamin NN cord-337849-tyabf12r 324 33 D3 D3 NNP cord-337849-tyabf12r 325 1 attenuates attenuate VBZ cord-337849-tyabf12r 325 2 Th2 th2 CD cord-337849-tyabf12r 325 3 responses response NNS cord-337849-tyabf12r 325 4 to to IN cord-337849-tyabf12r 325 5 Aspergillus aspergillus NN cord-337849-tyabf12r 325 6 fumigatus fumigatus NN cord-337849-tyabf12r 325 7 mounted mount VBN cord-337849-tyabf12r 325 8 by by IN cord-337849-tyabf12r 325 9 CD4 CD4 NNP cord-337849-tyabf12r 325 10 + + CC cord-337849-tyabf12r 325 11 T T NNP cord-337849-tyabf12r 325 12 cells cell NNS cord-337849-tyabf12r 325 13 from from IN cord-337849-tyabf12r 325 14 cystic cystic JJ cord-337849-tyabf12r 325 15 fibrosis fibrosis NN cord-337849-tyabf12r 325 16 patients patient NNS cord-337849-tyabf12r 325 17 with with IN cord-337849-tyabf12r 325 18 allergic allergic JJ cord-337849-tyabf12r 325 19 bronchopulmonary bronchopulmonary NNP cord-337849-tyabf12r 325 20 aspergillosis aspergillosis NNP cord-337849-tyabf12r 325 21 Availability Availability NNP cord-337849-tyabf12r 325 22 of of IN cord-337849-tyabf12r 325 23 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 325 24 D(3 D(3 NNS cord-337849-tyabf12r 325 25 ) ) -RRB- cord-337849-tyabf12r 326 1 to to IN cord-337849-tyabf12r 326 2 APCs apc NNS cord-337849-tyabf12r 326 3 controls control VBZ cord-337849-tyabf12r 326 4 the the DT cord-337849-tyabf12r 326 5 balance balance NN cord-337849-tyabf12r 326 6 between between IN cord-337849-tyabf12r 326 7 regulatory regulatory JJ cord-337849-tyabf12r 326 8 and and CC cord-337849-tyabf12r 326 9 inflammatory inflammatory JJ cord-337849-tyabf12r 326 10 T t NN cord-337849-tyabf12r 326 11 cell cell NN cord-337849-tyabf12r 326 12 responses response NNS cord-337849-tyabf12r 326 13 Frequency frequency NN cord-337849-tyabf12r 326 14 and and CC cord-337849-tyabf12r 326 15 natural natural JJ cord-337849-tyabf12r 326 16 history history NN cord-337849-tyabf12r 326 17 of of IN cord-337849-tyabf12r 326 18 rhinovirus rhinovirus JJ cord-337849-tyabf12r 326 19 infections infection NNS cord-337849-tyabf12r 326 20 in in IN cord-337849-tyabf12r 326 21 adults adult NNS cord-337849-tyabf12r 326 22 during during IN cord-337849-tyabf12r 326 23 autumn autumn NN cord-337849-tyabf12r 327 1 The the DT cord-337849-tyabf12r 327 2 common common JJ cord-337849-tyabf12r 327 3 cold cold JJ cord-337849-tyabf12r 327 4 Studies Studies NNPS cord-337849-tyabf12r 327 5 of of IN cord-337849-tyabf12r 327 6 the the DT cord-337849-tyabf12r 327 7 community community NN cord-337849-tyabf12r 327 8 and and CC cord-337849-tyabf12r 327 9 family family NN cord-337849-tyabf12r 327 10 : : : cord-337849-tyabf12r 328 1 Acute acute JJ cord-337849-tyabf12r 328 2 respiratory respiratory JJ cord-337849-tyabf12r 328 3 illness illness NN cord-337849-tyabf12r 328 4 and and CC cord-337849-tyabf12r 328 5 infection infection NN cord-337849-tyabf12r 328 6 Effects effect NNS cord-337849-tyabf12r 328 7 of of IN cord-337849-tyabf12r 328 8 vitamin vitamin NN cord-337849-tyabf12r 328 9 D d NN cord-337849-tyabf12r 328 10 on on IN cord-337849-tyabf12r 328 11 airway airway JJ cord-337849-tyabf12r 328 12 epithelial epithelial JJ cord-337849-tyabf12r 328 13 cell cell NN cord-337849-tyabf12r 328 14 morphology morphology NN cord-337849-tyabf12r 328 15 and and CC cord-337849-tyabf12r 328 16 rhinovirus rhinovirus NN cord-337849-tyabf12r 328 17 replication replication NN cord-337849-tyabf12r 328 18 Respiratory respiratory JJ cord-337849-tyabf12r 328 19 syncytial syncytial JJ cord-337849-tyabf12r 328 20 virus virus NN cord-337849-tyabf12r 328 21 : : : cord-337849-tyabf12r 328 22 Current current JJ cord-337849-tyabf12r 328 23 and and CC cord-337849-tyabf12r 328 24 emerging emerge VBG cord-337849-tyabf12r 328 25 treatment treatment NN cord-337849-tyabf12r 328 26 options option NNS cord-337849-tyabf12r 328 27 Respiratory respiratory JJ cord-337849-tyabf12r 328 28 syncytial syncytial JJ cord-337849-tyabf12r 328 29 virus virus NN cord-337849-tyabf12r 328 30 -- -- : cord-337849-tyabf12r 328 31 a a DT cord-337849-tyabf12r 328 32 comprehensive comprehensive JJ cord-337849-tyabf12r 328 33 review review NN cord-337849-tyabf12r 328 34 Severe severe JJ cord-337849-tyabf12r 328 35 respiratory respiratory JJ cord-337849-tyabf12r 328 36 syncytial syncytial JJ cord-337849-tyabf12r 328 37 virus virus NN cord-337849-tyabf12r 328 38 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 328 39 in in IN cord-337849-tyabf12r 328 40 infancy infancy NN cord-337849-tyabf12r 328 41 and and CC cord-337849-tyabf12r 328 42 asthma asthma NN cord-337849-tyabf12r 328 43 and and CC cord-337849-tyabf12r 328 44 allergy allergy NN cord-337849-tyabf12r 328 45 at at IN cord-337849-tyabf12r 328 46 age age NN cord-337849-tyabf12r 328 47 13 13 CD cord-337849-tyabf12r 328 48 Cord cord NN cord-337849-tyabf12r 328 49 blood blood NN cord-337849-tyabf12r 328 50 vitamin vitamin NN cord-337849-tyabf12r 328 51 D d NN cord-337849-tyabf12r 328 52 deficiency deficiency NN cord-337849-tyabf12r 328 53 is be VBZ cord-337849-tyabf12r 328 54 associated associate VBN cord-337849-tyabf12r 328 55 with with IN cord-337849-tyabf12r 328 56 respiratory respiratory JJ cord-337849-tyabf12r 328 57 syncytial syncytial JJ cord-337849-tyabf12r 328 58 virus virus NN cord-337849-tyabf12r 328 59 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 328 60 Genetic genetic JJ cord-337849-tyabf12r 328 61 predisposition predisposition NN cord-337849-tyabf12r 328 62 of of IN cord-337849-tyabf12r 328 63 RSV RSV NNP cord-337849-tyabf12r 328 64 infection infection NN cord-337849-tyabf12r 328 65 - - HYPH cord-337849-tyabf12r 328 66 related relate VBN cord-337849-tyabf12r 328 67 respiratory respiratory JJ cord-337849-tyabf12r 328 68 morbidity morbidity NN cord-337849-tyabf12r 328 69 in in IN cord-337849-tyabf12r 328 70 preterm preterm JJ cord-337849-tyabf12r 328 71 infants infant NNS cord-337849-tyabf12r 328 72 Vitamin vitamin NN cord-337849-tyabf12r 328 73 D d NN cord-337849-tyabf12r 328 74 receptor receptor NN cord-337849-tyabf12r 328 75 ( ( -LRB- cord-337849-tyabf12r 328 76 VDR VDR NNP cord-337849-tyabf12r 328 77 ) ) -RRB- cord-337849-tyabf12r 328 78 polymorphisms polymorphism NNS cord-337849-tyabf12r 328 79 and and CC cord-337849-tyabf12r 328 80 severe severe JJ cord-337849-tyabf12r 328 81 RSV RSV NNP cord-337849-tyabf12r 328 82 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 328 83 : : : cord-337849-tyabf12r 329 1 A a DT cord-337849-tyabf12r 329 2 systematic systematic JJ cord-337849-tyabf12r 329 3 review review NN cord-337849-tyabf12r 329 4 and and CC cord-337849-tyabf12r 329 5 meta meta NNP cord-337849-tyabf12r 329 6 - - HYPH cord-337849-tyabf12r 329 7 analysis analysis NNP cord-337849-tyabf12r 329 8 Confirmation Confirmation NNP cord-337849-tyabf12r 329 9 of of IN cord-337849-tyabf12r 329 10 an an DT cord-337849-tyabf12r 329 11 association association NN cord-337849-tyabf12r 329 12 between between IN cord-337849-tyabf12r 329 13 single single JJ cord-337849-tyabf12r 329 14 nucleotide nucleotide JJ cord-337849-tyabf12r 329 15 polymorphisms polymorphism NNS cord-337849-tyabf12r 329 16 in in IN cord-337849-tyabf12r 329 17 the the DT cord-337849-tyabf12r 329 18 VDR VDR NNP cord-337849-tyabf12r 329 19 gene gene NN cord-337849-tyabf12r 329 20 with with IN cord-337849-tyabf12r 329 21 respiratory respiratory JJ cord-337849-tyabf12r 329 22 syncytial syncytial JJ cord-337849-tyabf12r 329 23 virus virus NN cord-337849-tyabf12r 329 24 related relate VBN cord-337849-tyabf12r 329 25 disease disease NN cord-337849-tyabf12r 329 26 in in IN cord-337849-tyabf12r 329 27 South south JJ cord-337849-tyabf12r 329 28 African african JJ cord-337849-tyabf12r 329 29 children child NNS cord-337849-tyabf12r 330 1 Vitamin vitamin NN cord-337849-tyabf12r 330 2 D d NN cord-337849-tyabf12r 330 3 - - HYPH cord-337849-tyabf12r 330 4 binding bind VBG cord-337849-tyabf12r 330 5 protein protein NN cord-337849-tyabf12r 330 6 haplotype haplotype NN cord-337849-tyabf12r 330 7 is be VBZ cord-337849-tyabf12r 330 8 associated associate VBN cord-337849-tyabf12r 330 9 with with IN cord-337849-tyabf12r 330 10 hospitalization hospitalization NN cord-337849-tyabf12r 330 11 for for IN cord-337849-tyabf12r 330 12 RSV RSV NNP cord-337849-tyabf12r 330 13 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 330 14 Vitamin vitamin NN cord-337849-tyabf12r 330 15 D D NNP cord-337849-tyabf12r 330 16 decreases decrease VBZ cord-337849-tyabf12r 330 17 respiratory respiratory JJ cord-337849-tyabf12r 330 18 syncytial syncytial JJ cord-337849-tyabf12r 330 19 virus virus NN cord-337849-tyabf12r 330 20 induction induction NN cord-337849-tyabf12r 330 21 of of IN cord-337849-tyabf12r 330 22 NF NF NNP cord-337849-tyabf12r 330 23 - - HYPH cord-337849-tyabf12r 330 24 kappaB kappaB NNP cord-337849-tyabf12r 330 25 - - HYPH cord-337849-tyabf12r 330 26 linked link VBN cord-337849-tyabf12r 330 27 chemokines chemokine NNS cord-337849-tyabf12r 330 28 and and CC cord-337849-tyabf12r 330 29 cytokines cytokine NNS cord-337849-tyabf12r 330 30 in in IN cord-337849-tyabf12r 330 31 airway airway NN cord-337849-tyabf12r 330 32 epithelium epithelium NN cord-337849-tyabf12r 330 33 while while IN cord-337849-tyabf12r 330 34 maintaining maintain VBG cord-337849-tyabf12r 330 35 the the DT cord-337849-tyabf12r 330 36 antiviral antiviral JJ cord-337849-tyabf12r 330 37 state state NN cord-337849-tyabf12r 330 38 Defective defective JJ cord-337849-tyabf12r 330 39 control control NN cord-337849-tyabf12r 330 40 of of IN cord-337849-tyabf12r 330 41 vitamin vitamin NN cord-337849-tyabf12r 330 42 D D NNP cord-337849-tyabf12r 330 43 receptor receptor NN cord-337849-tyabf12r 330 44 - - HYPH cord-337849-tyabf12r 330 45 mediated mediate VBN cord-337849-tyabf12r 330 46 epithelial epithelial JJ cord-337849-tyabf12r 330 47 STAT1 stat1 NN cord-337849-tyabf12r 330 48 signaling signal VBG cord-337849-tyabf12r 330 49 predisposes predispose VBZ cord-337849-tyabf12r 330 50 to to IN cord-337849-tyabf12r 330 51 severe severe JJ cord-337849-tyabf12r 330 52 respiratory respiratory JJ cord-337849-tyabf12r 330 53 syncytial syncytial JJ cord-337849-tyabf12r 330 54 virus virus NN cord-337849-tyabf12r 330 55 bronchiolitis bronchiolitis NN cord-337849-tyabf12r 330 56 Differential differential JJ cord-337849-tyabf12r 330 57 expression expression NN cord-337849-tyabf12r 330 58 of of IN cord-337849-tyabf12r 330 59 cytokines cytokine NNS cord-337849-tyabf12r 330 60 in in IN cord-337849-tyabf12r 330 61 response response NN cord-337849-tyabf12r 330 62 to to IN cord-337849-tyabf12r 330 63 respiratory respiratory JJ cord-337849-tyabf12r 330 64 syncytial syncytial JJ cord-337849-tyabf12r 330 65 virus virus NN cord-337849-tyabf12r 330 66 infection infection NN cord-337849-tyabf12r 330 67 of of IN cord-337849-tyabf12r 330 68 calves calf NNS cord-337849-tyabf12r 330 69 with with IN cord-337849-tyabf12r 330 70 high high JJ cord-337849-tyabf12r 330 71 or or CC cord-337849-tyabf12r 330 72 low low JJ cord-337849-tyabf12r 330 73 circulating circulate VBG cord-337849-tyabf12r 330 74 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 330 75 D3 D3 NNP cord-337849-tyabf12r 330 76 Differential Differential NNP cord-337849-tyabf12r 330 77 chemokine chemokine NN cord-337849-tyabf12r 330 78 and and CC cord-337849-tyabf12r 330 79 cytokine cytokine NN cord-337849-tyabf12r 330 80 production production NN cord-337849-tyabf12r 330 81 by by IN cord-337849-tyabf12r 330 82 neonatal neonatal JJ cord-337849-tyabf12r 330 83 bovine bovine NN cord-337849-tyabf12r 330 84 γδ γδ IN cord-337849-tyabf12r 330 85 T t NN cord-337849-tyabf12r 330 86 - - HYPH cord-337849-tyabf12r 330 87 cell cell NN cord-337849-tyabf12r 330 88 subsets subset NNS cord-337849-tyabf12r 330 89 in in IN cord-337849-tyabf12r 330 90 response response NN cord-337849-tyabf12r 330 91 to to IN cord-337849-tyabf12r 330 92 viral viral JJ cord-337849-tyabf12r 330 93 toll toll NN cord-337849-tyabf12r 330 94 - - HYPH cord-337849-tyabf12r 330 95 like like JJ cord-337849-tyabf12r 330 96 receptor receptor NN cord-337849-tyabf12r 330 97 agonists agonist NNS cord-337849-tyabf12r 330 98 and and CC cord-337849-tyabf12r 330 99 in in IN cord-337849-tyabf12r 330 100 vivo vivo NN cord-337849-tyabf12r 330 101 respiratory respiratory JJ cord-337849-tyabf12r 330 102 syncytial syncytial JJ cord-337849-tyabf12r 330 103 virus virus NN cord-337849-tyabf12r 330 104 infection infection NN cord-337849-tyabf12r 330 105 Calcitriol Calcitriol NNP cord-337849-tyabf12r 330 106 [ [ -LRB- cord-337849-tyabf12r 330 107 1 1 CD cord-337849-tyabf12r 330 108 , , , cord-337849-tyabf12r 330 109 25[OH]2 25[OH]2 NNP cord-337849-tyabf12r 330 110 D3 D3 NNP cord-337849-tyabf12r 330 111 ] ] -RRB- cord-337849-tyabf12r 330 112 pre pre JJ cord-337849-tyabf12r 330 113 - - JJ cord-337849-tyabf12r 330 114 and and CC cord-337849-tyabf12r 330 115 post post JJ cord-337849-tyabf12r 330 116 - - NN cord-337849-tyabf12r 330 117 treatment treatment NN cord-337849-tyabf12r 330 118 suppresses suppress VBZ cord-337849-tyabf12r 330 119 inflammatory inflammatory JJ cord-337849-tyabf12r 330 120 response response NN cord-337849-tyabf12r 330 121 to to TO cord-337849-tyabf12r 330 122 influenza influenza VB cord-337849-tyabf12r 330 123 A a DT cord-337849-tyabf12r 330 124 ( ( -LRB- cord-337849-tyabf12r 330 125 H1N1 H1N1 NNP cord-337849-tyabf12r 330 126 ) ) -RRB- cord-337849-tyabf12r 330 127 infection infection NN cord-337849-tyabf12r 330 128 in in IN cord-337849-tyabf12r 330 129 human human JJ cord-337849-tyabf12r 330 130 lung lung NN cord-337849-tyabf12r 330 131 A549 a549 CD cord-337849-tyabf12r 330 132 epithelial epithelial JJ cord-337849-tyabf12r 330 133 cells cell NNS cord-337849-tyabf12r 330 134 Th1 th1 NN cord-337849-tyabf12r 330 135 and and CC cord-337849-tyabf12r 330 136 Th17 Th17 NNP cord-337849-tyabf12r 330 137 hypercytokinemia hypercytokinemia NNP cord-337849-tyabf12r 330 138 as as IN cord-337849-tyabf12r 330 139 early early JJ cord-337849-tyabf12r 330 140 host host NN cord-337849-tyabf12r 330 141 response response NN cord-337849-tyabf12r 330 142 signature signature NN cord-337849-tyabf12r 330 143 in in IN cord-337849-tyabf12r 330 144 severe severe JJ cord-337849-tyabf12r 330 145 pandemic pandemic NN cord-337849-tyabf12r 330 146 influenza influenza NN cord-337849-tyabf12r 330 147 Interactions Interactions NNPS cord-337849-tyabf12r 330 148 of of IN cord-337849-tyabf12r 330 149 alpha- alpha- NN cord-337849-tyabf12r 330 150 , , , cord-337849-tyabf12r 330 151 beta- beta- NN cord-337849-tyabf12r 330 152 , , , cord-337849-tyabf12r 330 153 and and CC cord-337849-tyabf12r 330 154 theta theta NN cord-337849-tyabf12r 330 155 - - HYPH cord-337849-tyabf12r 330 156 defensins defensin NNS cord-337849-tyabf12r 330 157 with with IN cord-337849-tyabf12r 330 158 influenza influenza NN cord-337849-tyabf12r 330 159 A a DT cord-337849-tyabf12r 330 160 virus virus NN cord-337849-tyabf12r 330 161 and and CC cord-337849-tyabf12r 330 162 surfactant surfactant NN cord-337849-tyabf12r 330 163 protein protein NN cord-337849-tyabf12r 330 164 D D NNP cord-337849-tyabf12r 330 165 Calcitriol Calcitriol NNP cord-337849-tyabf12r 330 166 ( ( -LRB- cord-337849-tyabf12r 330 167 1,25-dihydroxy 1,25-dihydroxy CD cord-337849-tyabf12r 330 168 - - HYPH cord-337849-tyabf12r 330 169 vitamin vitamin NN cord-337849-tyabf12r 330 170 D3 D3 NNP cord-337849-tyabf12r 330 171 ) ) -RRB- cord-337849-tyabf12r 331 1 coadministered coadministered NNP cord-337849-tyabf12r 331 2 with with IN cord-337849-tyabf12r 331 3 influenza influenza NN cord-337849-tyabf12r 331 4 vaccine vaccine NN cord-337849-tyabf12r 331 5 does do VBZ cord-337849-tyabf12r 331 6 not not RB cord-337849-tyabf12r 331 7 enhance enhance VB cord-337849-tyabf12r 331 8 humoral humoral JJ cord-337849-tyabf12r 331 9 immunity immunity NN cord-337849-tyabf12r 331 10 in in IN cord-337849-tyabf12r 331 11 human human JJ cord-337849-tyabf12r 331 12 volunteers volunteer NNS cord-337849-tyabf12r 331 13 Vitamin vitamin NN cord-337849-tyabf12r 331 14 D d NN cord-337849-tyabf12r 331 15 is be VBZ cord-337849-tyabf12r 331 16 not not RB cord-337849-tyabf12r 331 17 associated associate VBN cord-337849-tyabf12r 331 18 with with IN cord-337849-tyabf12r 331 19 serologic serologic JJ cord-337849-tyabf12r 331 20 response response NN cord-337849-tyabf12r 331 21 to to IN cord-337849-tyabf12r 331 22 influenza influenza NN cord-337849-tyabf12r 331 23 vaccine vaccine NN cord-337849-tyabf12r 331 24 in in IN cord-337849-tyabf12r 331 25 adults adult NNS cord-337849-tyabf12r 331 26 over over IN cord-337849-tyabf12r 331 27 50 50 CD cord-337849-tyabf12r 331 28 years year NNS cord-337849-tyabf12r 331 29 old old JJ cord-337849-tyabf12r 331 30 Impact impact NN cord-337849-tyabf12r 331 31 of of IN cord-337849-tyabf12r 331 32 vitamin vitamin NN cord-337849-tyabf12r 331 33 D D NNP cord-337849-tyabf12r 331 34 administration administration NN cord-337849-tyabf12r 331 35 on on IN cord-337849-tyabf12r 331 36 immunogenicity immunogenicity NN cord-337849-tyabf12r 331 37 of of IN cord-337849-tyabf12r 331 38 trivalent trivalent JJ cord-337849-tyabf12r 331 39 inactivated inactivate VBN cord-337849-tyabf12r 331 40 influenza influenza NN cord-337849-tyabf12r 331 41 vaccine vaccine NN cord-337849-tyabf12r 331 42 in in IN cord-337849-tyabf12r 331 43 previously previously RB cord-337849-tyabf12r 331 44 unvaccinated unvaccinated JJ cord-337849-tyabf12r 331 45 children child NNS cord-337849-tyabf12r 332 1 Vitamin vitamin NN cord-337849-tyabf12r 332 2 D d NN cord-337849-tyabf12r 332 3 supplementation supplementation NN cord-337849-tyabf12r 332 4 does do VBZ cord-337849-tyabf12r 332 5 not not RB cord-337849-tyabf12r 332 6 increase increase VB cord-337849-tyabf12r 332 7 immunogenicity immunogenicity NN cord-337849-tyabf12r 332 8 of of IN cord-337849-tyabf12r 332 9 seasonal seasonal JJ cord-337849-tyabf12r 332 10 influenza influenza NN cord-337849-tyabf12r 332 11 vaccine vaccine NN cord-337849-tyabf12r 332 12 in in IN cord-337849-tyabf12r 332 13 HIV HIV NNP cord-337849-tyabf12r 332 14 - - HYPH cord-337849-tyabf12r 332 15 infected infect VBN cord-337849-tyabf12r 332 16 adults adult NNS cord-337849-tyabf12r 333 1 Serum serum NN cord-337849-tyabf12r 333 2 25-hydroxyvitamin 25-hydroxyvitamin CD cord-337849-tyabf12r 333 3 d d CD cord-337849-tyabf12r 333 4 level level NN cord-337849-tyabf12r 333 5 and and CC cord-337849-tyabf12r 333 6 influenza influenza NN cord-337849-tyabf12r 333 7 vaccine vaccine NN cord-337849-tyabf12r 333 8 immunogenicity immunogenicity NN cord-337849-tyabf12r 333 9 in in IN cord-337849-tyabf12r 333 10 children child NNS cord-337849-tyabf12r 333 11 and and CC cord-337849-tyabf12r 333 12 adolescents adolescent NNS