id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309381-cb80ntxs	Nogales, Aitor	Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans	2019-09-30		.txt	text/plain	10222	590	45	IAV RNAs are mainly recognized by the endosomal, membrane-associated PRR Toll-like receptors (TLRs) 3 (double-stranded RNAs, dsRNAs) or 7/8 (ssRNAs), respectively [50, 51] , by the cytoplasmic PRR retinoic acid-inducible gene I (RIG-I), which detects dsRNA and 5 -triphosphates of the negative ssRNA viral genome [50, 52] , generated during replication of multiple viruses, by the NOD-like receptor family member NOD-, LRR-and pyrin domain-containing 3 (NLRP3), which recognizes various stimuli (see below) [53] and by the absent in melanoma 2 (AIM2) protein, recognizing not well-characterized influenza stimuli [54] . Another important SNP (rs34481144) associated with risk of severe influenza in humans from the United States (US) infected with seasonal IAVs is located in the 5 -UTR of the IFITM3 gene [123, 124] .	./cache/cord-309381-cb80ntxs.txt	./txt/cord-309381-cb80ntxs.txt