id	sid	tid	token	lemma	pos
cord-334907-l4jjb93l	1	1	key	key	JJ
cord-334907-l4jjb93l	2	1	:	:	:
cord-334907-l4jjb93l	2	2	cord-334907-l4jjb93l	cord-334907-l4jjb93l	CD
cord-334907-l4jjb93l	2	3	authors	author	NNS
cord-334907-l4jjb93l	2	4	:	:	:
cord-334907-l4jjb93l	2	5	Ojeda	Ojeda	NNP
cord-334907-l4jjb93l	2	6	,	,	,
cord-334907-l4jjb93l	2	7	Nicolás	Nicolás	NNP
cord-334907-l4jjb93l	2	8	;	;	:
cord-334907-l4jjb93l	2	9	Cárdenas	Cárdenas	NNP
cord-334907-l4jjb93l	2	10	,	,	,
cord-334907-l4jjb93l	2	11	Constanza	Constanza	NNP
cord-334907-l4jjb93l	2	12	;	;	:
cord-334907-l4jjb93l	2	13	Marshall	Marshall	NNP
cord-334907-l4jjb93l	2	14	,	,	,
cord-334907-l4jjb93l	2	15	Sergio	Sergio	NNP
cord-334907-l4jjb93l	2	16	title	title	NN
cord-334907-l4jjb93l	2	17	:	:	:
cord-334907-l4jjb93l	2	18	Interaction	interaction	NN
cord-334907-l4jjb93l	2	19	of	of	IN
cord-334907-l4jjb93l	2	20	the	the	DT
cord-334907-l4jjb93l	2	21	Amino	Amino	NNP
cord-334907-l4jjb93l	2	22	-	-	HYPH
cord-334907-l4jjb93l	2	23	Terminal	Terminal	NNP
cord-334907-l4jjb93l	2	24	Domain	Domain	NNP
cord-334907-l4jjb93l	2	25	of	of	IN
cord-334907-l4jjb93l	2	26	the	the	DT
cord-334907-l4jjb93l	2	27	ISAV	ISAV	NNP
cord-334907-l4jjb93l	2	28	Fusion	Fusion	NNP
cord-334907-l4jjb93l	2	29	Protein	Protein	NNP
cord-334907-l4jjb93l	2	30	with	with	IN
cord-334907-l4jjb93l	2	31	a	a	DT
cord-334907-l4jjb93l	2	32	Cognate	Cognate	NNP
cord-334907-l4jjb93l	2	33	Cell	Cell	NNP
cord-334907-l4jjb93l	2	34	Receptor	Receptor	NNP
cord-334907-l4jjb93l	2	35	date	date	NN
cord-334907-l4jjb93l	2	36	:	:	:
cord-334907-l4jjb93l	2	37	2020	2020	CD
cord-334907-l4jjb93l	2	38	-	-	HYPH
cord-334907-l4jjb93l	2	39	05	05	CD
cord-334907-l4jjb93l	2	40	-	-	HYPH
cord-334907-l4jjb93l	2	41	27	27	CD
cord-334907-l4jjb93l	2	42	journal	journal	NN
cord-334907-l4jjb93l	2	43	:	:	:
cord-334907-l4jjb93l	3	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	4	1	DOI	DOI	NNP
cord-334907-l4jjb93l	4	2	:	:	:
cord-334907-l4jjb93l	5	1	10.3390	10.3390	CD
cord-334907-l4jjb93l	6	1	/pathogens9060416	/pathogens9060416	NFP
cord-334907-l4jjb93l	6	2	sha	sha	NNP
cord-334907-l4jjb93l	6	3	:	:	:
cord-334907-l4jjb93l	6	4	7a80e5351099c04ae97a83b9c8cbcb6cb326848f	7a80e5351099c04ae97a83b9c8cbcb6cb326848f	NNP
cord-334907-l4jjb93l	6	5	doc_id	doc_id	NNPS
cord-334907-l4jjb93l	6	6	:	:	:
cord-334907-l4jjb93l	6	7	334907	334907	CD
cord-334907-l4jjb93l	6	8	cord_uid	cord_uid	NNS
cord-334907-l4jjb93l	6	9	:	:	:
cord-334907-l4jjb93l	7	1	l4jjb93l	l4jjb93l	NNP
cord-334907-l4jjb93l	8	1	The	the	DT
cord-334907-l4jjb93l	8	2	infectious	infectious	JJ
cord-334907-l4jjb93l	8	3	salmon	salmon	NN
cord-334907-l4jjb93l	8	4	anemia	anemia	NN
cord-334907-l4jjb93l	8	5	virus	virus	NN
cord-334907-l4jjb93l	8	6	(	(	-LRB-
cord-334907-l4jjb93l	8	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	8	8	)	)	-RRB-
cord-334907-l4jjb93l	8	9	,	,	,
cord-334907-l4jjb93l	8	10	etiological	etiological	JJ
cord-334907-l4jjb93l	8	11	agent	agent	NN
cord-334907-l4jjb93l	8	12	of	of	IN
cord-334907-l4jjb93l	8	13	the	the	DT
cord-334907-l4jjb93l	8	14	disease	disease	NN
cord-334907-l4jjb93l	8	15	by	by	IN
cord-334907-l4jjb93l	8	16	the	the	DT
cord-334907-l4jjb93l	8	17	same	same	JJ
cord-334907-l4jjb93l	8	18	name	name	NN
cord-334907-l4jjb93l	8	19	,	,	,
cord-334907-l4jjb93l	8	20	causes	cause	VBZ
cord-334907-l4jjb93l	8	21	major	major	JJ
cord-334907-l4jjb93l	8	22	losses	loss	NNS
cord-334907-l4jjb93l	8	23	to	to	IN
cord-334907-l4jjb93l	8	24	the	the	DT
cord-334907-l4jjb93l	8	25	salmon	salmon	NN
cord-334907-l4jjb93l	8	26	industry	industry	NN
cord-334907-l4jjb93l	8	27	.	.	.
cord-334907-l4jjb93l	9	1	Classified	classify	VBN
cord-334907-l4jjb93l	9	2	as	as	IN
cord-334907-l4jjb93l	9	3	a	a	DT
cord-334907-l4jjb93l	9	4	member	member	NN
cord-334907-l4jjb93l	9	5	of	of	IN
cord-334907-l4jjb93l	9	6	the	the	DT
cord-334907-l4jjb93l	9	7	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-334907-l4jjb93l	9	8	family	family	NN
cord-334907-l4jjb93l	9	9	,	,	,
cord-334907-l4jjb93l	9	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	9	11	is	be	VBZ
cord-334907-l4jjb93l	9	12	characterized	characterize	VBN
cord-334907-l4jjb93l	9	13	by	by	IN
cord-334907-l4jjb93l	9	14	the	the	DT
cord-334907-l4jjb93l	9	15	presence	presence	NN
cord-334907-l4jjb93l	9	16	of	of	IN
cord-334907-l4jjb93l	9	17	two	two	CD
cord-334907-l4jjb93l	9	18	surface	surface	NN
cord-334907-l4jjb93l	9	19	glycoproteins	glycoprotein	NNS
cord-334907-l4jjb93l	9	20	termed	term	VBD
cord-334907-l4jjb93l	9	21	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	9	22	esterase	esterase	NN
cord-334907-l4jjb93l	9	23	(	(	-LRB-
cord-334907-l4jjb93l	9	24	HE	HE	NNP
cord-334907-l4jjb93l	9	25	)	)	-RRB-
cord-334907-l4jjb93l	9	26	and	and	CC
cord-334907-l4jjb93l	9	27	fusion	fusion	NN
cord-334907-l4jjb93l	9	28	protein	protein	NN
cord-334907-l4jjb93l	9	29	(	(	-LRB-
cord-334907-l4jjb93l	9	30	F	F	NNP
cord-334907-l4jjb93l	9	31	)	)	-RRB-
cord-334907-l4jjb93l	9	32	,	,	,
cord-334907-l4jjb93l	9	33	both	both	DT
cord-334907-l4jjb93l	9	34	of	of	IN
cord-334907-l4jjb93l	9	35	them	-PRON-	PRP
cord-334907-l4jjb93l	9	36	directly	directly	RB
cord-334907-l4jjb93l	9	37	involved	involve	VBN
cord-334907-l4jjb93l	9	38	in	in	IN
cord-334907-l4jjb93l	9	39	the	the	DT
cord-334907-l4jjb93l	9	40	initial	initial	JJ
cord-334907-l4jjb93l	9	41	interaction	interaction	NN
cord-334907-l4jjb93l	9	42	of	of	IN
cord-334907-l4jjb93l	9	43	the	the	DT
cord-334907-l4jjb93l	9	44	virus	virus	NN
cord-334907-l4jjb93l	9	45	with	with	IN
cord-334907-l4jjb93l	9	46	the	the	DT
cord-334907-l4jjb93l	9	47	target	target	NN
cord-334907-l4jjb93l	9	48	cell	cell	NN
cord-334907-l4jjb93l	9	49	.	.	.
cord-334907-l4jjb93l	10	1	HE	he	PRP
cord-334907-l4jjb93l	10	2	mediates	mediate	VBZ
cord-334907-l4jjb93l	10	3	receptor	receptor	NN
cord-334907-l4jjb93l	10	4	binding	binding	NN
cord-334907-l4jjb93l	10	5	and	and	CC
cord-334907-l4jjb93l	10	6	destruction	destruction	NN
cord-334907-l4jjb93l	10	7	,	,	,
cord-334907-l4jjb93l	10	8	while	while	IN
cord-334907-l4jjb93l	10	9	F	F	NNP
cord-334907-l4jjb93l	10	10	promotes	promote	VBZ
cord-334907-l4jjb93l	10	11	the	the	DT
cord-334907-l4jjb93l	10	12	fusion	fusion	NN
cord-334907-l4jjb93l	10	13	process	process	NN
cord-334907-l4jjb93l	10	14	of	of	IN
cord-334907-l4jjb93l	10	15	the	the	DT
cord-334907-l4jjb93l	10	16	viral	viral	JJ
cord-334907-l4jjb93l	10	17	and	and	CC
cord-334907-l4jjb93l	10	18	cell	cell	NN
cord-334907-l4jjb93l	10	19	membranes	membrane	NNS
cord-334907-l4jjb93l	10	20	.	.	.
cord-334907-l4jjb93l	11	1	The	the	DT
cord-334907-l4jjb93l	11	2	carboxy	carboxy	JJ
cord-334907-l4jjb93l	11	3	-	-	HYPH
cord-334907-l4jjb93l	11	4	terminal	terminal	NN
cord-334907-l4jjb93l	11	5	end	end	NN
cord-334907-l4jjb93l	11	6	of	of	IN
cord-334907-l4jjb93l	11	7	F	F	NNP
cord-334907-l4jjb93l	11	8	(	(	-LRB-
cord-334907-l4jjb93l	11	9	F(2	F(2	NNP
cord-334907-l4jjb93l	11	10	)	)	-RRB-
cord-334907-l4jjb93l	11	11	)	)	-RRB-
cord-334907-l4jjb93l	11	12	possesses	possess	VBZ
cord-334907-l4jjb93l	11	13	canonical	canonical	JJ
cord-334907-l4jjb93l	11	14	structural	structural	JJ
cord-334907-l4jjb93l	11	15	characteristics	characteristic	NNS
cord-334907-l4jjb93l	11	16	of	of	IN
cord-334907-l4jjb93l	11	17	a	a	DT
cord-334907-l4jjb93l	11	18	type	type	NN
cord-334907-l4jjb93l	11	19	I	-PRON-	PRP
cord-334907-l4jjb93l	11	20	fusion	fusion	NN
cord-334907-l4jjb93l	11	21	protein	protein	NN
cord-334907-l4jjb93l	11	22	,	,	,
cord-334907-l4jjb93l	11	23	while	while	IN
cord-334907-l4jjb93l	11	24	no	no	DT
cord-334907-l4jjb93l	11	25	functional	functional	JJ
cord-334907-l4jjb93l	11	26	properties	property	NNS
cord-334907-l4jjb93l	11	27	have	have	VBP
cord-334907-l4jjb93l	11	28	been	be	VBN
cord-334907-l4jjb93l	11	29	proposed	propose	VBN
cord-334907-l4jjb93l	11	30	for	for	IN
cord-334907-l4jjb93l	11	31	the	the	DT
cord-334907-l4jjb93l	11	32	amino	amino	NN
cord-334907-l4jjb93l	11	33	-	-	HYPH
cord-334907-l4jjb93l	11	34	terminal	terminal	NN
cord-334907-l4jjb93l	11	35	(	(	-LRB-
cord-334907-l4jjb93l	11	36	F(1	F(1	NNP
cord-334907-l4jjb93l	11	37	)	)	-RRB-
cord-334907-l4jjb93l	11	38	)	)	-RRB-
cord-334907-l4jjb93l	11	39	region	region	NN
cord-334907-l4jjb93l	11	40	.	.	.
cord-334907-l4jjb93l	12	1	In	in	IN
cord-334907-l4jjb93l	12	2	this	this	DT
cord-334907-l4jjb93l	12	3	report	report	NN
cord-334907-l4jjb93l	12	4	,	,	,
cord-334907-l4jjb93l	12	5	based	base	VBN
cord-334907-l4jjb93l	12	6	on	on	IN
cord-334907-l4jjb93l	12	7	in	in	IN
cord-334907-l4jjb93l	12	8	silico	silico	NN
cord-334907-l4jjb93l	12	9	modeling	modeling	NN
cord-334907-l4jjb93l	12	10	,	,	,
cord-334907-l4jjb93l	12	11	we	-PRON-	PRP
cord-334907-l4jjb93l	12	12	propose	propose	VBP
cord-334907-l4jjb93l	12	13	a	a	DT
cord-334907-l4jjb93l	12	14	tertiary	tertiary	JJ
cord-334907-l4jjb93l	12	15	structure	structure	NN
cord-334907-l4jjb93l	12	16	for	for	IN
cord-334907-l4jjb93l	12	17	the	the	DT
cord-334907-l4jjb93l	12	18	F(1	F(1	NNP
cord-334907-l4jjb93l	12	19	)	)	-RRB-
cord-334907-l4jjb93l	12	20	region	region	NN
cord-334907-l4jjb93l	12	21	,	,	,
cord-334907-l4jjb93l	12	22	which	which	WDT
cord-334907-l4jjb93l	12	23	resembles	resemble	VBZ
cord-334907-l4jjb93l	12	24	a	a	DT
cord-334907-l4jjb93l	12	25	sialic	sialic	JJ
cord-334907-l4jjb93l	12	26	acid	acid	NN
cord-334907-l4jjb93l	12	27	binding	bind	VBG
cord-334907-l4jjb93l	12	28	domain	domain	NN
cord-334907-l4jjb93l	12	29	.	.	.
cord-334907-l4jjb93l	13	1	Furthermore	furthermore	RB
cord-334907-l4jjb93l	13	2	,	,	,
cord-334907-l4jjb93l	13	3	using	use	VBG
cord-334907-l4jjb93l	13	4	recombinant	recombinant	JJ
cord-334907-l4jjb93l	13	5	forms	form	NNS
cord-334907-l4jjb93l	13	6	of	of	IN
cord-334907-l4jjb93l	13	7	both	both	CC
cord-334907-l4jjb93l	13	8	HE	HE	NNP
cord-334907-l4jjb93l	13	9	and	and	CC
cord-334907-l4jjb93l	13	10	F	F	NNP
cord-334907-l4jjb93l	13	11	proteins	protein	NNS
cord-334907-l4jjb93l	13	12	and	and	CC
cord-334907-l4jjb93l	13	13	an	an	DT
cord-334907-l4jjb93l	13	14	in	in	FW
cord-334907-l4jjb93l	13	15	vitro	vitro	FW
cord-334907-l4jjb93l	13	16	model	model	NN
cord-334907-l4jjb93l	13	17	system	system	NN
cord-334907-l4jjb93l	13	18	,	,	,
cord-334907-l4jjb93l	13	19	we	-PRON-	PRP
cord-334907-l4jjb93l	13	20	demonstrate	demonstrate	VBP
cord-334907-l4jjb93l	13	21	the	the	DT
cord-334907-l4jjb93l	13	22	interaction	interaction	NN
cord-334907-l4jjb93l	13	23	of	of	IN
cord-334907-l4jjb93l	13	24	F	F	NNP
cord-334907-l4jjb93l	13	25	with	with	IN
cord-334907-l4jjb93l	13	26	a	a	DT
cord-334907-l4jjb93l	13	27	cell	cell	NN
cord-334907-l4jjb93l	13	28	receptor	receptor	NN
cord-334907-l4jjb93l	13	29	,	,	,
cord-334907-l4jjb93l	13	30	the	the	DT
cord-334907-l4jjb93l	13	31	hydrolysis	hydrolysis	NN
cord-334907-l4jjb93l	13	32	of	of	IN
cord-334907-l4jjb93l	13	33	this	this	DT
cord-334907-l4jjb93l	13	34	receptor	receptor	NN
cord-334907-l4jjb93l	13	35	by	by	IN
cord-334907-l4jjb93l	13	36	the	the	DT
cord-334907-l4jjb93l	13	37	HE	HE	NNP
cord-334907-l4jjb93l	13	38	esterase	esterase	NN
cord-334907-l4jjb93l	13	39	,	,	,
cord-334907-l4jjb93l	13	40	and	and	CC
cord-334907-l4jjb93l	13	41	a	a	DT
cord-334907-l4jjb93l	13	42	crucial	crucial	JJ
cord-334907-l4jjb93l	13	43	role	role	NN
cord-334907-l4jjb93l	13	44	for	for	IN
cord-334907-l4jjb93l	13	45	F(1	F(1	NNP
cord-334907-l4jjb93l	13	46	)	)	-RRB-
cord-334907-l4jjb93l	13	47	in	in	IN
cord-334907-l4jjb93l	13	48	the	the	DT
cord-334907-l4jjb93l	13	49	fusion	fusion	NN
cord-334907-l4jjb93l	13	50	mechanism	mechanism	NN
cord-334907-l4jjb93l	13	51	.	.	.
cord-334907-l4jjb93l	14	1	Our	-PRON-	PRP$
cord-334907-l4jjb93l	14	2	interpretation	interpretation	NN
cord-334907-l4jjb93l	14	3	is	be	VBZ
cord-334907-l4jjb93l	14	4	that	that	IN
cord-334907-l4jjb93l	14	5	binding	binding	NN
cord-334907-l4jjb93l	14	6	of	of	IN
cord-334907-l4jjb93l	14	7	F	F	NNP
cord-334907-l4jjb93l	14	8	to	to	IN
cord-334907-l4jjb93l	14	9	its	-PRON-	PRP$
cord-334907-l4jjb93l	14	10	cell	cell	NN
cord-334907-l4jjb93l	14	11	receptor	receptor	NN
cord-334907-l4jjb93l	14	12	is	be	VBZ
cord-334907-l4jjb93l	14	13	fundamental	fundamental	JJ
cord-334907-l4jjb93l	14	14	for	for	IN
cord-334907-l4jjb93l	14	15	membrane	membrane	NN
cord-334907-l4jjb93l	14	16	fusion	fusion	NN
cord-334907-l4jjb93l	14	17	and	and	CC
cord-334907-l4jjb93l	14	18	that	that	IN
cord-334907-l4jjb93l	14	19	the	the	DT
cord-334907-l4jjb93l	14	20	esterase	esterase	NN
cord-334907-l4jjb93l	14	21	in	in	IN
cord-334907-l4jjb93l	14	22	HE	he	PRP
cord-334907-l4jjb93l	14	23	modulates	modulate	VBZ
cord-334907-l4jjb93l	14	24	this	this	DT
cord-334907-l4jjb93l	14	25	interaction	interaction	NN
cord-334907-l4jjb93l	14	26	.	.	.
cord-334907-l4jjb93l	15	1	Infectious	infectious	JJ
cord-334907-l4jjb93l	15	2	salmon	salmon	NN
cord-334907-l4jjb93l	15	3	anemia	anemia	NN
cord-334907-l4jjb93l	15	4	(	(	-LRB-
cord-334907-l4jjb93l	15	5	ISA	ISA	NNP
cord-334907-l4jjb93l	15	6	)	)	-RRB-
cord-334907-l4jjb93l	15	7	is	be	VBZ
cord-334907-l4jjb93l	15	8	an	an	DT
cord-334907-l4jjb93l	15	9	aggressive	aggressive	JJ
cord-334907-l4jjb93l	15	10	disease	disease	NN
cord-334907-l4jjb93l	15	11	that	that	WDT
cord-334907-l4jjb93l	15	12	primarily	primarily	RB
cord-334907-l4jjb93l	15	13	affects	affect	VBZ
cord-334907-l4jjb93l	15	14	Atlantic	atlantic	JJ
cord-334907-l4jjb93l	15	15	salmon	salmon	NN
cord-334907-l4jjb93l	15	16	(	(	-LRB-
cord-334907-l4jjb93l	15	17	Salmo	Salmo	NNP
cord-334907-l4jjb93l	15	18	salar	salar	NNP
cord-334907-l4jjb93l	15	19	)	)	-RRB-
cord-334907-l4jjb93l	15	20	,	,	,
cord-334907-l4jjb93l	15	21	one	one	CD
cord-334907-l4jjb93l	15	22	of	of	IN
cord-334907-l4jjb93l	15	23	the	the	DT
cord-334907-l4jjb93l	15	24	most	most	RBS
cord-334907-l4jjb93l	15	25	commercially	commercially	RB
cord-334907-l4jjb93l	15	26	relevant	relevant	JJ
cord-334907-l4jjb93l	15	27	farmed	farm	VBN
cord-334907-l4jjb93l	15	28	fish	fish	NN
cord-334907-l4jjb93l	15	29	.	.	.
cord-334907-l4jjb93l	16	1	The	the	DT
cord-334907-l4jjb93l	16	2	disease	disease	NN
cord-334907-l4jjb93l	16	3	has	have	VBZ
cord-334907-l4jjb93l	16	4	high	high	JJ
cord-334907-l4jjb93l	16	5	mortality	mortality	NN
cord-334907-l4jjb93l	16	6	rates	rate	NNS
cord-334907-l4jjb93l	16	7	,	,	,
cord-334907-l4jjb93l	16	8	with	with	IN
cord-334907-l4jjb93l	16	9	outbreaks	outbreak	NNS
cord-334907-l4jjb93l	16	10	occurring	occur	VBG
cord-334907-l4jjb93l	16	11	at	at	IN
cord-334907-l4jjb93l	16	12	later	later	JJ
cord-334907-l4jjb93l	16	13	stages	stage	NNS
cord-334907-l4jjb93l	16	14	of	of	IN
cord-334907-l4jjb93l	16	15	the	the	DT
cord-334907-l4jjb93l	16	16	breeding	breeding	NN
cord-334907-l4jjb93l	16	17	process	process	NN
cord-334907-l4jjb93l	16	18	,	,	,
cord-334907-l4jjb93l	16	19	seriously	seriously	RB
cord-334907-l4jjb93l	16	20	impacting	impact	VBG
cord-334907-l4jjb93l	16	21	the	the	DT
cord-334907-l4jjb93l	16	22	industry	industry	NN
cord-334907-l4jjb93l	16	23	's	's	POS
cord-334907-l4jjb93l	16	24	sustainability	sustainability	NN
cord-334907-l4jjb93l	16	25	[	[	-LRB-
cord-334907-l4jjb93l	16	26	1	1	CD
cord-334907-l4jjb93l	16	27	]	]	-RRB-
cord-334907-l4jjb93l	16	28	.	.	.
cord-334907-l4jjb93l	17	1	ISA	ISA	NNP
cord-334907-l4jjb93l	17	2	has	have	VBZ
cord-334907-l4jjb93l	17	3	affected	affect	VBN
cord-334907-l4jjb93l	17	4	all	all	DT
cord-334907-l4jjb93l	17	5	major	major	JJ
cord-334907-l4jjb93l	17	6	salmon	salmon	NN
cord-334907-l4jjb93l	17	7	-	-	HYPH
cord-334907-l4jjb93l	17	8	producing	produce	VBG
cord-334907-l4jjb93l	17	9	countries	country	NNS
cord-334907-l4jjb93l	17	10	,	,	,
cord-334907-l4jjb93l	17	11	including	include	VBG
cord-334907-l4jjb93l	17	12	Canada	Canada	NNP
cord-334907-l4jjb93l	17	13	,	,	,
cord-334907-l4jjb93l	17	14	Norway	Norway	NNP
cord-334907-l4jjb93l	17	15	,	,	,
cord-334907-l4jjb93l	17	16	Scotland	Scotland	NNP
cord-334907-l4jjb93l	17	17	,	,	,
cord-334907-l4jjb93l	17	18	the	the	DT
cord-334907-l4jjb93l	17	19	Faroe	Faroe	NNP
cord-334907-l4jjb93l	17	20	Islands	Islands	NNPS
cord-334907-l4jjb93l	17	21	,	,	,
cord-334907-l4jjb93l	17	22	and	and	CC
cord-334907-l4jjb93l	17	23	Chile	Chile	NNP
cord-334907-l4jjb93l	17	24	[	[	-LRB-
cord-334907-l4jjb93l	17	25	2	2	CD
cord-334907-l4jjb93l	17	26	]	]	-RRB-
cord-334907-l4jjb93l	17	27	[	[	-LRB-
cord-334907-l4jjb93l	17	28	3	3	CD
cord-334907-l4jjb93l	17	29	]	]	-RRB-
cord-334907-l4jjb93l	17	30	[	[	-LRB-
cord-334907-l4jjb93l	17	31	4	4	CD
cord-334907-l4jjb93l	17	32	]	]	-RRB-
cord-334907-l4jjb93l	17	33	[	[	-LRB-
cord-334907-l4jjb93l	17	34	5	5	CD
cord-334907-l4jjb93l	17	35	]	]	-RRB-
cord-334907-l4jjb93l	17	36	[	[	-LRB-
cord-334907-l4jjb93l	17	37	6	6	CD
cord-334907-l4jjb93l	17	38	]	]	-RRB-
cord-334907-l4jjb93l	17	39	.	.	.
cord-334907-l4jjb93l	18	1	The	the	DT
cord-334907-l4jjb93l	18	2	etiological	etiological	JJ
cord-334907-l4jjb93l	18	3	agent	agent	NN
cord-334907-l4jjb93l	18	4	of	of	IN
cord-334907-l4jjb93l	18	5	ISA	ISA	NNP
cord-334907-l4jjb93l	18	6	is	be	VBZ
cord-334907-l4jjb93l	18	7	a	a	DT
cord-334907-l4jjb93l	18	8	relatively	relatively	RB
cord-334907-l4jjb93l	18	9	new	new	JJ
cord-334907-l4jjb93l	18	10	virus	virus	NN
cord-334907-l4jjb93l	18	11	within	within	IN
cord-334907-l4jjb93l	18	12	the	the	DT
cord-334907-l4jjb93l	18	13	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-334907-l4jjb93l	18	14	family	family	NN
cord-334907-l4jjb93l	18	15	and	and	CC
cord-334907-l4jjb93l	18	16	is	be	VBZ
cord-334907-l4jjb93l	18	17	the	the	DT
cord-334907-l4jjb93l	18	18	only	only	JJ
cord-334907-l4jjb93l	18	19	member	member	NN
cord-334907-l4jjb93l	18	20	of	of	IN
cord-334907-l4jjb93l	18	21	the	the	DT
cord-334907-l4jjb93l	18	22	novel	novel	JJ
cord-334907-l4jjb93l	18	23	Isavirus	Isavirus	NNP
cord-334907-l4jjb93l	18	24	genus	genus	NN
cord-334907-l4jjb93l	18	25	[	[	-LRB-
cord-334907-l4jjb93l	18	26	7	7	CD
cord-334907-l4jjb93l	18	27	]	]	-RRB-
cord-334907-l4jjb93l	18	28	.	.	.
cord-334907-l4jjb93l	19	1	The	the	DT
cord-334907-l4jjb93l	19	2	infectious	infectious	JJ
cord-334907-l4jjb93l	19	3	salmon	salmon	NN
cord-334907-l4jjb93l	19	4	anemia	anemia	NN
cord-334907-l4jjb93l	19	5	virus	virus	NN
cord-334907-l4jjb93l	19	6	(	(	-LRB-
cord-334907-l4jjb93l	19	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	19	8	)	)	-RRB-
cord-334907-l4jjb93l	19	9	shares	share	VBZ
cord-334907-l4jjb93l	19	10	similarities	similarity	NNS
cord-334907-l4jjb93l	19	11	with	with	IN
cord-334907-l4jjb93l	19	12	other	other	JJ
cord-334907-l4jjb93l	19	13	members	member	NNS
cord-334907-l4jjb93l	19	14	of	of	IN
cord-334907-l4jjb93l	19	15	the	the	DT
cord-334907-l4jjb93l	19	16	family	family	NN
cord-334907-l4jjb93l	19	17	,	,	,
cord-334907-l4jjb93l	19	18	including	include	VBG
cord-334907-l4jjb93l	19	19	a	a	DT
cord-334907-l4jjb93l	19	20	segmented	segmented	JJ
cord-334907-l4jjb93l	19	21	single	single	RB
cord-334907-l4jjb93l	19	22	-	-	HYPH
cord-334907-l4jjb93l	19	23	stranded	strand	VBN
cord-334907-l4jjb93l	19	24	negative	negative	JJ
cord-334907-l4jjb93l	19	25	-	-	HYPH
cord-334907-l4jjb93l	19	26	sense	sense	NN
cord-334907-l4jjb93l	19	27	RNA	RNA	NNP
cord-334907-l4jjb93l	19	28	genome	genome	NN
cord-334907-l4jjb93l	19	29	and	and	CC
cord-334907-l4jjb93l	19	30	a	a	DT
cord-334907-l4jjb93l	19	31	viral	viral	JJ
cord-334907-l4jjb93l	19	32	envelope	envelope	NN
cord-334907-l4jjb93l	19	33	[	[	-LRB-
cord-334907-l4jjb93l	19	34	8	8	CD
cord-334907-l4jjb93l	19	35	,	,	,
cord-334907-l4jjb93l	19	36	9	9	CD
cord-334907-l4jjb93l	19	37	]	]	-RRB-
cord-334907-l4jjb93l	19	38	.	.	.
cord-334907-l4jjb93l	20	1	The	the	DT
cord-334907-l4jjb93l	20	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	20	3	envelope	envelope	NN
cord-334907-l4jjb93l	20	4	contains	contain	VBZ
cord-334907-l4jjb93l	20	5	two	two	CD
cord-334907-l4jjb93l	20	6	major	major	JJ
cord-334907-l4jjb93l	20	7	glycoproteins	glycoprotein	NNS
cord-334907-l4jjb93l	20	8	that	that	WDT
cord-334907-l4jjb93l	20	9	mediate	mediate	VBP
cord-334907-l4jjb93l	20	10	binding	binding	NN
cord-334907-l4jjb93l	20	11	,	,	,
cord-334907-l4jjb93l	20	12	membrane	membrane	NN
cord-334907-l4jjb93l	20	13	fusion	fusion	NN
cord-334907-l4jjb93l	20	14	,	,	,
cord-334907-l4jjb93l	20	15	and	and	CC
cord-334907-l4jjb93l	20	16	receptor	receptor	NN
cord-334907-l4jjb93l	20	17	destruction	destruction	NN
cord-334907-l4jjb93l	20	18	.	.	.
cord-334907-l4jjb93l	21	1	One	one	CD
cord-334907-l4jjb93l	21	2	of	of	IN
cord-334907-l4jjb93l	21	3	them	-PRON-	PRP
cord-334907-l4jjb93l	21	4	is	be	VBZ
cord-334907-l4jjb93l	21	5	a	a	DT
cord-334907-l4jjb93l	21	6	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	21	7	esterase	esterase	NN
cord-334907-l4jjb93l	21	8	(	(	-LRB-
cord-334907-l4jjb93l	21	9	HE	he	NN
cord-334907-l4jjb93l	21	10	)	)	-RRB-
cord-334907-l4jjb93l	21	11	which	which	WDT
cord-334907-l4jjb93l	21	12	interacts	interact	VBZ
cord-334907-l4jjb93l	21	13	with	with	IN
cord-334907-l4jjb93l	21	14	sialic	sialic	JJ
cord-334907-l4jjb93l	21	15	acids	acid	NNS
cord-334907-l4jjb93l	21	16	on	on	IN
cord-334907-l4jjb93l	21	17	the	the	DT
cord-334907-l4jjb93l	21	18	susceptible	susceptible	JJ
cord-334907-l4jjb93l	21	19	cell	cell	NN
cord-334907-l4jjb93l	21	20	surface	surface	NN
cord-334907-l4jjb93l	21	21	via	via	IN
cord-334907-l4jjb93l	21	22	the	the	DT
cord-334907-l4jjb93l	21	23	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	21	24	domain	domain	NN
cord-334907-l4jjb93l	21	25	,	,	,
cord-334907-l4jjb93l	21	26	promoting	promote	VBG
cord-334907-l4jjb93l	21	27	viral	viral	JJ
cord-334907-l4jjb93l	21	28	attachment	attachment	NN
cord-334907-l4jjb93l	21	29	;	;	:
cord-334907-l4jjb93l	21	30	on	on	IN
cord-334907-l4jjb93l	21	31	the	the	DT
cord-334907-l4jjb93l	21	32	other	other	JJ
cord-334907-l4jjb93l	21	33	hand	hand	NN
cord-334907-l4jjb93l	21	34	,	,	,
cord-334907-l4jjb93l	21	35	the	the	DT
cord-334907-l4jjb93l	21	36	esterase	esterase	NN
cord-334907-l4jjb93l	21	37	acts	act	VBZ
cord-334907-l4jjb93l	21	38	as	as	IN
cord-334907-l4jjb93l	21	39	a	a	DT
cord-334907-l4jjb93l	21	40	receptor	receptor	NN
cord-334907-l4jjb93l	21	41	-	-	HYPH
cord-334907-l4jjb93l	21	42	destroying	destroy	VBG
cord-334907-l4jjb93l	21	43	enzyme	enzyme	NN
cord-334907-l4jjb93l	21	44	(	(	-LRB-
cord-334907-l4jjb93l	21	45	RDE	RDE	NNP
cord-334907-l4jjb93l	21	46	)	)	-RRB-
cord-334907-l4jjb93l	21	47	,	,	,
cord-334907-l4jjb93l	21	48	allowing	allow	VBG
cord-334907-l4jjb93l	21	49	the	the	DT
cord-334907-l4jjb93l	21	50	release	release	NN
cord-334907-l4jjb93l	21	51	of	of	IN
cord-334907-l4jjb93l	21	52	new	new	JJ
cord-334907-l4jjb93l	21	53	viral	viral	JJ
cord-334907-l4jjb93l	21	54	particles	particle	NNS
cord-334907-l4jjb93l	21	55	in	in	IN
cord-334907-l4jjb93l	21	56	the	the	DT
cord-334907-l4jjb93l	21	57	context	context	NN
cord-334907-l4jjb93l	21	58	of	of	IN
cord-334907-l4jjb93l	21	59	a	a	DT
cord-334907-l4jjb93l	21	60	productive	productive	JJ
cord-334907-l4jjb93l	21	61	infection	infection	NN
cord-334907-l4jjb93l	21	62	[	[	-LRB-
cord-334907-l4jjb93l	21	63	10	10	CD
cord-334907-l4jjb93l	21	64	,	,	,
cord-334907-l4jjb93l	21	65	11	11	CD
cord-334907-l4jjb93l	21	66	]	]	-RRB-
cord-334907-l4jjb93l	21	67	.	.	.
cord-334907-l4jjb93l	22	1	The	the	DT
cord-334907-l4jjb93l	22	2	second	second	JJ
cord-334907-l4jjb93l	22	3	ISAV	ISAV	NNP
cord-334907-l4jjb93l	22	4	envelope	envelope	NN
cord-334907-l4jjb93l	22	5	protein	protein	NN
cord-334907-l4jjb93l	22	6	is	be	VBZ
cord-334907-l4jjb93l	22	7	known	know	VBN
cord-334907-l4jjb93l	22	8	as	as	IN
cord-334907-l4jjb93l	22	9	fusion	fusion	NN
cord-334907-l4jjb93l	22	10	protein	protein	NN
cord-334907-l4jjb93l	22	11	(	(	-LRB-
cord-334907-l4jjb93l	22	12	F	F	NNP
cord-334907-l4jjb93l	22	13	)	)	-RRB-
cord-334907-l4jjb93l	22	14	and	and	CC
cord-334907-l4jjb93l	22	15	mediates	mediate	VBZ
cord-334907-l4jjb93l	22	16	the	the	DT
cord-334907-l4jjb93l	22	17	fusion	fusion	NN
cord-334907-l4jjb93l	22	18	process	process	NN
cord-334907-l4jjb93l	22	19	of	of	IN
cord-334907-l4jjb93l	22	20	the	the	DT
cord-334907-l4jjb93l	22	21	viral	viral	JJ
cord-334907-l4jjb93l	22	22	and	and	CC
cord-334907-l4jjb93l	22	23	cellular	cellular	JJ
cord-334907-l4jjb93l	22	24	membranes	membrane	NNS
cord-334907-l4jjb93l	22	25	.	.	.
cord-334907-l4jjb93l	23	1	Cleavage	cleavage	NN
cord-334907-l4jjb93l	23	2	of	of	IN
cord-334907-l4jjb93l	23	3	F	F	NNP
cord-334907-l4jjb93l	23	4	by	by	IN
cord-334907-l4jjb93l	23	5	extracellular	extracellular	JJ
cord-334907-l4jjb93l	23	6	proteases	protease	NNS
cord-334907-l4jjb93l	23	7	and	and	CC
cord-334907-l4jjb93l	23	8	a	a	DT
cord-334907-l4jjb93l	23	9	pH	ph	NN
cord-334907-l4jjb93l	23	10	-	-	HYPH
cord-334907-l4jjb93l	23	11	mediated	mediate	VBN
cord-334907-l4jjb93l	23	12	conformational	conformational	JJ
cord-334907-l4jjb93l	23	13	change	change	NN
cord-334907-l4jjb93l	23	14	,	,	,
cord-334907-l4jjb93l	23	15	once	once	RB
cord-334907-l4jjb93l	23	16	inside	inside	IN
cord-334907-l4jjb93l	23	17	the	the	DT
cord-334907-l4jjb93l	23	18	endosome	endosome	NN
cord-334907-l4jjb93l	23	19	,	,	,
cord-334907-l4jjb93l	23	20	are	be	VBP
cord-334907-l4jjb93l	23	21	necessary	necessary	JJ
cord-334907-l4jjb93l	23	22	for	for	IN
cord-334907-l4jjb93l	23	23	the	the	DT
cord-334907-l4jjb93l	23	24	activation	activation	NN
cord-334907-l4jjb93l	23	25	of	of	IN
cord-334907-l4jjb93l	23	26	the	the	DT
cord-334907-l4jjb93l	23	27	fusion	fusion	NN
cord-334907-l4jjb93l	23	28	mechanism	mechanism	NN
cord-334907-l4jjb93l	23	29	[	[	-LRB-
cord-334907-l4jjb93l	23	30	12	12	CD
cord-334907-l4jjb93l	23	31	,	,	,
cord-334907-l4jjb93l	23	32	13	13	CD
cord-334907-l4jjb93l	23	33	]	]	-RRB-
cord-334907-l4jjb93l	23	34	.	.	.
cord-334907-l4jjb93l	24	1	Viral	viral	JJ
cord-334907-l4jjb93l	24	2	genome	genome	NN
cord-334907-l4jjb93l	24	3	segments	segment	NNS
cord-334907-l4jjb93l	24	4	6	6	CD
cord-334907-l4jjb93l	24	5	and	and	CC
cord-334907-l4jjb93l	24	6	5	5	CD
cord-334907-l4jjb93l	24	7	code	code	NN
cord-334907-l4jjb93l	24	8	for	for	IN
cord-334907-l4jjb93l	24	9	HE	HE	NNP
cord-334907-l4jjb93l	24	10	and	and	CC
cord-334907-l4jjb93l	24	11	F	F	NNP
cord-334907-l4jjb93l	24	12	,	,	,
cord-334907-l4jjb93l	24	13	respectively	respectively	RB
cord-334907-l4jjb93l	24	14	.	.	.
cord-334907-l4jjb93l	25	1	Virulence	virulence	NN
cord-334907-l4jjb93l	25	2	markers	marker	NNS
cord-334907-l4jjb93l	25	3	have	have	VBP
cord-334907-l4jjb93l	25	4	been	be	VBN
cord-334907-l4jjb93l	25	5	described	describe	VBN
cord-334907-l4jjb93l	25	6	on	on	IN
cord-334907-l4jjb93l	25	7	both	both	DT
cord-334907-l4jjb93l	25	8	genes	gene	NNS
cord-334907-l4jjb93l	25	9	,	,	,
cord-334907-l4jjb93l	25	10	particularly	particularly	RB
cord-334907-l4jjb93l	25	11	deletions	deletion	NNS
cord-334907-l4jjb93l	25	12	in	in	IN
cord-334907-l4jjb93l	25	13	a	a	DT
cord-334907-l4jjb93l	25	14	highly	highly	RB
cord-334907-l4jjb93l	25	15	polymorphic	polymorphic	JJ
cord-334907-l4jjb93l	25	16	region	region	NN
cord-334907-l4jjb93l	25	17	(	(	-LRB-
cord-334907-l4jjb93l	25	18	HPR	HPR	NNP
cord-334907-l4jjb93l	25	19	)	)	-RRB-
cord-334907-l4jjb93l	25	20	on	on	IN
cord-334907-l4jjb93l	25	21	segment	segment	NN
cord-334907-l4jjb93l	25	22	6	6	CD
cord-334907-l4jjb93l	25	23	,	,	,
cord-334907-l4jjb93l	25	24	corresponding	correspond	VBG
cord-334907-l4jjb93l	25	25	to	to	IN
cord-334907-l4jjb93l	25	26	a	a	DT
cord-334907-l4jjb93l	25	27	region	region	NN
cord-334907-l4jjb93l	25	28	of	of	IN
cord-334907-l4jjb93l	25	29	the	the	DT
cord-334907-l4jjb93l	25	30	protein	protein	NN
cord-334907-l4jjb93l	25	31	located	locate	VBN
cord-334907-l4jjb93l	25	32	near	near	IN
cord-334907-l4jjb93l	25	33	the	the	DT
cord-334907-l4jjb93l	25	34	transmembrane	transmembrane	NN
cord-334907-l4jjb93l	25	35	domain	domain	NN
cord-334907-l4jjb93l	25	36	(	(	-LRB-
cord-334907-l4jjb93l	25	37	i.e.	i.e.	FW
cord-334907-l4jjb93l	25	38	,	,	,
cord-334907-l4jjb93l	25	39	stalk	stalk	VB
cord-334907-l4jjb93l	25	40	region	region	NN
cord-334907-l4jjb93l	25	41	)	)	-RRB-
cord-334907-l4jjb93l	25	42	,	,	,
cord-334907-l4jjb93l	25	43	Pathogens	Pathogens	NNPS
cord-334907-l4jjb93l	25	44	2020	2020	CD
cord-334907-l4jjb93l	25	45	,	,	,
cord-334907-l4jjb93l	25	46	9	9	CD
cord-334907-l4jjb93l	25	47	,	,	,
cord-334907-l4jjb93l	25	48	416	416	CD
cord-334907-l4jjb93l	25	49	2	2	CD
cord-334907-l4jjb93l	25	50	of	of	IN
cord-334907-l4jjb93l	25	51	18	18	CD
cord-334907-l4jjb93l	25	52	and	and	CC
cord-334907-l4jjb93l	25	53	insertions	insertion	NNS
cord-334907-l4jjb93l	25	54	near	near	IN
cord-334907-l4jjb93l	25	55	the	the	DT
cord-334907-l4jjb93l	25	56	cleavage	cleavage	NN
cord-334907-l4jjb93l	25	57	site	site	NN
cord-334907-l4jjb93l	25	58	for	for	IN
cord-334907-l4jjb93l	25	59	F	F	NNP
cord-334907-l4jjb93l	25	60	in	in	IN
cord-334907-l4jjb93l	25	61	segment	segment	NN
cord-334907-l4jjb93l	25	62	5	5	CD
cord-334907-l4jjb93l	25	63	[	[	-LRB-
cord-334907-l4jjb93l	25	64	14	14	CD
cord-334907-l4jjb93l	25	65	,	,	,
cord-334907-l4jjb93l	25	66	15	15	CD
cord-334907-l4jjb93l	25	67	]	]	-RRB-
cord-334907-l4jjb93l	25	68	.	.	.
cord-334907-l4jjb93l	26	1	Nonvirulent	Nonvirulent	NNP
cord-334907-l4jjb93l	26	2	strains	strain	NNS
cord-334907-l4jjb93l	26	3	of	of	IN
cord-334907-l4jjb93l	26	4	the	the	DT
cord-334907-l4jjb93l	26	5	virus	virus	NN
cord-334907-l4jjb93l	26	6	carry	carry	VBP
cord-334907-l4jjb93l	26	7	a	a	DT
cord-334907-l4jjb93l	26	8	full	full	JJ
cord-334907-l4jjb93l	26	9	-	-	HYPH
cord-334907-l4jjb93l	26	10	length	length	NN
cord-334907-l4jjb93l	26	11	HE	HE	NNP
cord-334907-l4jjb93l	26	12	gene	gene	NN
cord-334907-l4jjb93l	26	13	(	(	-LRB-
cord-334907-l4jjb93l	26	14	HPR0	HPR0	NNP
cord-334907-l4jjb93l	26	15	)	)	-RRB-
cord-334907-l4jjb93l	26	16	and	and	CC
cord-334907-l4jjb93l	26	17	have	have	VBP
cord-334907-l4jjb93l	26	18	not	not	RB
cord-334907-l4jjb93l	26	19	been	be	VBN
cord-334907-l4jjb93l	26	20	isolated	isolate	VBN
cord-334907-l4jjb93l	26	21	in	in	IN
cord-334907-l4jjb93l	26	22	ISAV	ISAV	NNP
cord-334907-l4jjb93l	26	23	-	-	HYPH
cord-334907-l4jjb93l	26	24	permissive	permissive	JJ
cord-334907-l4jjb93l	26	25	cell	cell	NN
cord-334907-l4jjb93l	26	26	lines	line	NNS
cord-334907-l4jjb93l	26	27	;	;	:
cord-334907-l4jjb93l	26	28	on	on	IN
cord-334907-l4jjb93l	26	29	the	the	DT
cord-334907-l4jjb93l	26	30	other	other	JJ
cord-334907-l4jjb93l	26	31	hand	hand	NN
cord-334907-l4jjb93l	26	32	,	,	,
cord-334907-l4jjb93l	26	33	highly	highly	RB
cord-334907-l4jjb93l	26	34	virulent	virulent	JJ
cord-334907-l4jjb93l	26	35	ISAV	ISAV	NNP
cord-334907-l4jjb93l	26	36	strains	strain	NNS
cord-334907-l4jjb93l	26	37	carry	carry	VBP
cord-334907-l4jjb93l	26	38	versions	version	NNS
cord-334907-l4jjb93l	26	39	of	of	IN
cord-334907-l4jjb93l	26	40	the	the	DT
cord-334907-l4jjb93l	26	41	HE	HE	NNP
cord-334907-l4jjb93l	26	42	gene	gene	NN
cord-334907-l4jjb93l	26	43	with	with	IN
cord-334907-l4jjb93l	26	44	deletions	deletion	NNS
cord-334907-l4jjb93l	26	45	in	in	IN
cord-334907-l4jjb93l	26	46	the	the	DT
cord-334907-l4jjb93l	26	47	HPR	HPR	NNP
cord-334907-l4jjb93l	26	48	(	(	-LRB-
cord-334907-l4jjb93l	26	49	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	26	50	)	)	-RRB-
cord-334907-l4jjb93l	26	51	,	,	,
cord-334907-l4jjb93l	26	52	suggesting	suggest	VBG
cord-334907-l4jjb93l	26	53	that	that	IN
cord-334907-l4jjb93l	26	54	the	the	DT
cord-334907-l4jjb93l	26	55	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	26	56	gene	gene	NN
cord-334907-l4jjb93l	26	57	constitutes	constitute	VBZ
cord-334907-l4jjb93l	26	58	the	the	DT
cord-334907-l4jjb93l	26	59	ancestral	ancestral	JJ
cord-334907-l4jjb93l	26	60	HE	HE	NNP
cord-334907-l4jjb93l	26	61	[	[	-LRB-
cord-334907-l4jjb93l	26	62	6	6	CD
cord-334907-l4jjb93l	26	63	,	,	,
cord-334907-l4jjb93l	26	64	16	16	CD
cord-334907-l4jjb93l	26	65	,	,	,
cord-334907-l4jjb93l	26	66	17	17	CD
cord-334907-l4jjb93l	26	67	]	]	-RRB-
cord-334907-l4jjb93l	26	68	.	.	.
cord-334907-l4jjb93l	27	1	Both	both	DT
cord-334907-l4jjb93l	27	2	HPR0	HPR0	NNP
cord-334907-l4jjb93l	27	3	and	and	CC
cord-334907-l4jjb93l	27	4	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	28	1	HE	HE	NNP
cord-334907-l4jjb93l	28	2	types	type	NNS
cord-334907-l4jjb93l	28	3	are	be	VBP
cord-334907-l4jjb93l	28	4	fully	fully	RB
cord-334907-l4jjb93l	28	5	functional	functional	JJ
cord-334907-l4jjb93l	28	6	in	in	IN
cord-334907-l4jjb93l	28	7	terms	term	NNS
cord-334907-l4jjb93l	28	8	of	of	IN
cord-334907-l4jjb93l	28	9	receptor	receptor	NN
cord-334907-l4jjb93l	28	10	-	-	HYPH
cord-334907-l4jjb93l	28	11	binding	binding	NN
cord-334907-l4jjb93l	28	12	and	and	CC
cord-334907-l4jjb93l	28	13	receptor	receptor	NN
cord-334907-l4jjb93l	28	14	-	-	HYPH
cord-334907-l4jjb93l	28	15	destroying	destroy	VBG
cord-334907-l4jjb93l	28	16	activities	activity	NNS
cord-334907-l4jjb93l	28	17	,	,	,
cord-334907-l4jjb93l	28	18	with	with	IN
cord-334907-l4jjb93l	28	19	a	a	DT
cord-334907-l4jjb93l	28	20	specific	specific	JJ
cord-334907-l4jjb93l	28	21	5N-4O	5n-4o	CD
cord-334907-l4jjb93l	28	22	acetylated	acetylated	JJ
cord-334907-l4jjb93l	28	23	sialic	sialic	NN
cord-334907-l4jjb93l	28	24	acid	acid	NN
cord-334907-l4jjb93l	28	25	on	on	IN
cord-334907-l4jjb93l	28	26	the	the	DT
cord-334907-l4jjb93l	28	27	cell	cell	NN
cord-334907-l4jjb93l	28	28	surface	surface	NN
cord-334907-l4jjb93l	28	29	being	be	VBG
cord-334907-l4jjb93l	28	30	identified	identify	VBN
cord-334907-l4jjb93l	28	31	as	as	IN
cord-334907-l4jjb93l	28	32	the	the	DT
cord-334907-l4jjb93l	28	33	viral	viral	JJ
cord-334907-l4jjb93l	28	34	receptor	receptor	NN
cord-334907-l4jjb93l	28	35	[	[	-LRB-
cord-334907-l4jjb93l	28	36	18	18	CD
cord-334907-l4jjb93l	28	37	]	]	-RRB-
cord-334907-l4jjb93l	28	38	.	.	.
cord-334907-l4jjb93l	29	1	Nevertheless	nevertheless	RB
cord-334907-l4jjb93l	29	2	,	,	,
cord-334907-l4jjb93l	29	3	the	the	DT
cord-334907-l4jjb93l	29	4	HPR	HPR	NNP
cord-334907-l4jjb93l	29	5	length	length	NN
cord-334907-l4jjb93l	29	6	seems	seem	VBZ
cord-334907-l4jjb93l	29	7	to	to	TO
cord-334907-l4jjb93l	29	8	have	have	VB
cord-334907-l4jjb93l	29	9	an	an	DT
cord-334907-l4jjb93l	29	10	influence	influence	NN
cord-334907-l4jjb93l	29	11	on	on	IN
cord-334907-l4jjb93l	29	12	the	the	DT
cord-334907-l4jjb93l	29	13	fusion	fusion	NN
cord-334907-l4jjb93l	29	14	mechanism	mechanism	NN
cord-334907-l4jjb93l	29	15	,	,	,
cord-334907-l4jjb93l	29	16	with	with	IN
cord-334907-l4jjb93l	29	17	HPR0	HPR0	NNP
cord-334907-l4jjb93l	29	18	HE	HE	NNP
cord-334907-l4jjb93l	29	19	having	have	VBG
cord-334907-l4jjb93l	29	20	lower	low	JJR
cord-334907-l4jjb93l	29	21	fusion	fusion	NN
cord-334907-l4jjb93l	29	22	activity	activity	NN
cord-334907-l4jjb93l	29	23	compared	compare	VBN
cord-334907-l4jjb93l	29	24	to	to	IN
cord-334907-l4jjb93l	29	25	the	the	DT
cord-334907-l4jjb93l	29	26	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	29	27	types	type	NNS
cord-334907-l4jjb93l	29	28	[	[	-LRB-
cord-334907-l4jjb93l	29	29	19	19	CD
cord-334907-l4jjb93l	29	30	]	]	-RRB-
cord-334907-l4jjb93l	29	31	.	.	.
cord-334907-l4jjb93l	30	1	In	in	IN
cord-334907-l4jjb93l	30	2	influenza	influenza	NN
cord-334907-l4jjb93l	30	3	virus	virus	NN
cord-334907-l4jjb93l	30	4	,	,	,
cord-334907-l4jjb93l	30	5	receptor	receptor	NN
cord-334907-l4jjb93l	30	6	binding	binding	NN
cord-334907-l4jjb93l	30	7	and	and	CC
cord-334907-l4jjb93l	30	8	membrane	membrane	NN
cord-334907-l4jjb93l	30	9	fusion	fusion	NN
cord-334907-l4jjb93l	30	10	are	be	VBP
cord-334907-l4jjb93l	30	11	mediated	mediate	VBN
cord-334907-l4jjb93l	30	12	by	by	IN
cord-334907-l4jjb93l	30	13	hemagglutinin	hemagglutinin	NNS
cord-334907-l4jjb93l	30	14	(	(	-LRB-
cord-334907-l4jjb93l	30	15	HA	HA	NNP
cord-334907-l4jjb93l	30	16	)	)	-RRB-
cord-334907-l4jjb93l	30	17	,	,	,
cord-334907-l4jjb93l	30	18	with	with	IN
cord-334907-l4jjb93l	30	19	neuraminidase	neuraminidase	FW
cord-334907-l4jjb93l	30	20	(	(	-LRB-
cord-334907-l4jjb93l	30	21	NA	NA	NNP
cord-334907-l4jjb93l	30	22	)	)	-RRB-
cord-334907-l4jjb93l	30	23	being	be	VBG
cord-334907-l4jjb93l	30	24	responsible	responsible	JJ
cord-334907-l4jjb93l	30	25	for	for	IN
cord-334907-l4jjb93l	30	26	receptor	receptor	NN
cord-334907-l4jjb93l	30	27	destruction	destruction	NN
cord-334907-l4jjb93l	30	28	activity	activity	NN
cord-334907-l4jjb93l	30	29	[	[	-LRB-
cord-334907-l4jjb93l	30	30	20	20	CD
cord-334907-l4jjb93l	30	31	]	]	-RRB-
cord-334907-l4jjb93l	30	32	.	.	.
cord-334907-l4jjb93l	31	1	Regarding	regard	VBG
cord-334907-l4jjb93l	31	2	NA	NA	NNP
cord-334907-l4jjb93l	31	3	,	,	,
cord-334907-l4jjb93l	31	4	hydrolysis	hydrolysis	NN
cord-334907-l4jjb93l	31	5	of	of	IN
cord-334907-l4jjb93l	31	6	sialic	sialic	JJ
cord-334907-l4jjb93l	31	7	acids	acid	NNS
cord-334907-l4jjb93l	31	8	is	be	VBZ
cord-334907-l4jjb93l	31	9	not	not	RB
cord-334907-l4jjb93l	31	10	only	only	RB
cord-334907-l4jjb93l	31	11	related	relate	VBN
cord-334907-l4jjb93l	31	12	to	to	IN
cord-334907-l4jjb93l	31	13	liberation	liberation	NN
cord-334907-l4jjb93l	31	14	of	of	IN
cord-334907-l4jjb93l	31	15	new	new	JJ
cord-334907-l4jjb93l	31	16	viral	viral	JJ
cord-334907-l4jjb93l	31	17	particles	particle	NNS
cord-334907-l4jjb93l	31	18	but	but	CC
cord-334907-l4jjb93l	31	19	also	also	RB
cord-334907-l4jjb93l	31	20	to	to	TO
cord-334907-l4jjb93l	31	21	cleavage	cleavage	NN
cord-334907-l4jjb93l	31	22	of	of	IN
cord-334907-l4jjb93l	31	23	mucins	mucin	NNS
cord-334907-l4jjb93l	31	24	from	from	IN
cord-334907-l4jjb93l	31	25	mucus	mucus	NN
cord-334907-l4jjb93l	31	26	,	,	,
cord-334907-l4jjb93l	31	27	allowing	allow	VBG
cord-334907-l4jjb93l	31	28	access	access	NN
cord-334907-l4jjb93l	31	29	to	to	IN
cord-334907-l4jjb93l	31	30	target	target	NN
cord-334907-l4jjb93l	31	31	cells	cell	NNS
cord-334907-l4jjb93l	31	32	,	,	,
cord-334907-l4jjb93l	31	33	and	and	CC
cord-334907-l4jjb93l	31	34	migration	migration	NN
cord-334907-l4jjb93l	31	35	of	of	IN
cord-334907-l4jjb93l	31	36	virions	virion	NNS
cord-334907-l4jjb93l	31	37	to	to	IN
cord-334907-l4jjb93l	31	38	appropriated	appropriate	VBN
cord-334907-l4jjb93l	31	39	entry	entry	NN
cord-334907-l4jjb93l	31	40	sites	site	NNS
cord-334907-l4jjb93l	31	41	on	on	IN
cord-334907-l4jjb93l	31	42	polarized	polarized	JJ
cord-334907-l4jjb93l	31	43	cells	cell	NNS
cord-334907-l4jjb93l	31	44	surfaces	surface	NNS
cord-334907-l4jjb93l	31	45	[	[	-LRB-
cord-334907-l4jjb93l	31	46	21	21	CD
cord-334907-l4jjb93l	31	47	,	,	,
cord-334907-l4jjb93l	31	48	22	22	CD
cord-334907-l4jjb93l	31	49	]	]	-RRB-
cord-334907-l4jjb93l	31	50	.	.	.
cord-334907-l4jjb93l	32	1	Thus	thus	RB
cord-334907-l4jjb93l	32	2	,	,	,
cord-334907-l4jjb93l	32	3	equilibrium	equilibrium	NN
cord-334907-l4jjb93l	32	4	in	in	IN
cord-334907-l4jjb93l	32	5	the	the	DT
cord-334907-l4jjb93l	32	6	receptor	receptor	NN
cord-334907-l4jjb93l	32	7	-	-	HYPH
cord-334907-l4jjb93l	32	8	binding	bind	VBG
cord-334907-l4jjb93l	32	9	/	/	SYM
cord-334907-l4jjb93l	32	10	receptor	receptor	NN
cord-334907-l4jjb93l	32	11	-	-	HYPH
cord-334907-l4jjb93l	32	12	destroying	destroy	VBG
cord-334907-l4jjb93l	32	13	activities	activity	NNS
cord-334907-l4jjb93l	32	14	has	have	VBZ
cord-334907-l4jjb93l	32	15	an	an	DT
cord-334907-l4jjb93l	32	16	important	important	JJ
cord-334907-l4jjb93l	32	17	role	role	NN
cord-334907-l4jjb93l	32	18	on	on	IN
cord-334907-l4jjb93l	32	19	the	the	DT
cord-334907-l4jjb93l	32	20	initial	initial	JJ
cord-334907-l4jjb93l	32	21	viral	viral	JJ
cord-334907-l4jjb93l	32	22	particle	particle	NN
cord-334907-l4jjb93l	32	23	interactions	interaction	NNS
cord-334907-l4jjb93l	32	24	with	with	IN
cord-334907-l4jjb93l	32	25	the	the	DT
cord-334907-l4jjb93l	32	26	cell	cell	NN
cord-334907-l4jjb93l	32	27	.	.	.
cord-334907-l4jjb93l	33	1	In	in	IN
cord-334907-l4jjb93l	33	2	influenza	influenza	NN
cord-334907-l4jjb93l	33	3	virus	virus	NN
cord-334907-l4jjb93l	33	4	,	,	,
cord-334907-l4jjb93l	33	5	variations	variation	NNS
cord-334907-l4jjb93l	33	6	in	in	IN
cord-334907-l4jjb93l	33	7	the	the	DT
cord-334907-l4jjb93l	33	8	length	length	NN
cord-334907-l4jjb93l	33	9	of	of	IN
cord-334907-l4jjb93l	33	10	the	the	DT
cord-334907-l4jjb93l	33	11	neuraminidase	neuraminidase	NN
cord-334907-l4jjb93l	33	12	stalk	stalk	NN
cord-334907-l4jjb93l	33	13	region	region	NN
cord-334907-l4jjb93l	33	14	have	have	VBP
cord-334907-l4jjb93l	33	15	been	be	VBN
cord-334907-l4jjb93l	33	16	associated	associate	VBN
cord-334907-l4jjb93l	33	17	with	with	IN
cord-334907-l4jjb93l	33	18	modifications	modification	NNS
cord-334907-l4jjb93l	33	19	in	in	IN
cord-334907-l4jjb93l	33	20	tropism	tropism	NN
cord-334907-l4jjb93l	33	21	and	and	CC
cord-334907-l4jjb93l	33	22	infectivity	infectivity	NN
cord-334907-l4jjb93l	33	23	,	,	,
cord-334907-l4jjb93l	33	24	with	with	IN
cord-334907-l4jjb93l	33	25	deletions	deletion	NNS
cord-334907-l4jjb93l	33	26	in	in	IN
cord-334907-l4jjb93l	33	27	this	this	DT
cord-334907-l4jjb93l	33	28	region	region	NN
cord-334907-l4jjb93l	33	29	of	of	IN
cord-334907-l4jjb93l	33	30	the	the	DT
cord-334907-l4jjb93l	33	31	NA	NA	NNP
cord-334907-l4jjb93l	33	32	gene	gene	NN
cord-334907-l4jjb93l	33	33	being	be	VBG
cord-334907-l4jjb93l	33	34	recognized	recognize	VBN
cord-334907-l4jjb93l	33	35	as	as	IN
cord-334907-l4jjb93l	33	36	virulence	virulence	NN
cord-334907-l4jjb93l	33	37	markers	marker	NNS
cord-334907-l4jjb93l	33	38	in	in	IN
cord-334907-l4jjb93l	33	39	avian	avian	JJ
cord-334907-l4jjb93l	33	40	strains	strain	NNS
cord-334907-l4jjb93l	33	41	[	[	-LRB-
cord-334907-l4jjb93l	33	42	23	23	CD
cord-334907-l4jjb93l	33	43	,	,	,
cord-334907-l4jjb93l	33	44	24	24	CD
cord-334907-l4jjb93l	33	45	]	]	-RRB-
cord-334907-l4jjb93l	33	46	.	.	.
cord-334907-l4jjb93l	34	1	A	a	DT
cord-334907-l4jjb93l	34	2	modification	modification	NN
cord-334907-l4jjb93l	34	3	in	in	IN
cord-334907-l4jjb93l	34	4	the	the	DT
cord-334907-l4jjb93l	34	5	length	length	NN
cord-334907-l4jjb93l	34	6	of	of	IN
cord-334907-l4jjb93l	34	7	the	the	DT
cord-334907-l4jjb93l	34	8	NA	NA	NNP
cord-334907-l4jjb93l	34	9	stalk	stalk	NN
cord-334907-l4jjb93l	34	10	region	region	NN
cord-334907-l4jjb93l	34	11	may	may	MD
cord-334907-l4jjb93l	34	12	affect	affect	VB
cord-334907-l4jjb93l	34	13	the	the	DT
cord-334907-l4jjb93l	34	14	substrate	substrate	JJ
cord-334907-l4jjb93l	34	15	accessibility	accessibility	NN
cord-334907-l4jjb93l	34	16	of	of	IN
cord-334907-l4jjb93l	34	17	the	the	DT
cord-334907-l4jjb93l	34	18	enzyme	enzyme	NN
cord-334907-l4jjb93l	34	19	,	,	,
cord-334907-l4jjb93l	34	20	altering	alter	VBG
cord-334907-l4jjb93l	34	21	the	the	DT
cord-334907-l4jjb93l	34	22	receptor	receptor	NN
cord-334907-l4jjb93l	34	23	-	-	HYPH
cord-334907-l4jjb93l	34	24	binding	bind	VBG
cord-334907-l4jjb93l	34	25	/	/	SYM
cord-334907-l4jjb93l	34	26	receptor	receptor	NN
cord-334907-l4jjb93l	34	27	-	-	HYPH
cord-334907-l4jjb93l	34	28	destroying	destroy	VBG
cord-334907-l4jjb93l	34	29	activities	activity	NNS
cord-334907-l4jjb93l	34	30	equilibrium	equilibrium	NN
cord-334907-l4jjb93l	34	31	and	and	CC
cord-334907-l4jjb93l	34	32	ultimately	ultimately	RB
cord-334907-l4jjb93l	34	33	affecting	affect	VBG
cord-334907-l4jjb93l	34	34	the	the	DT
cord-334907-l4jjb93l	34	35	viral	viral	JJ
cord-334907-l4jjb93l	34	36	infectivity	infectivity	NN
cord-334907-l4jjb93l	34	37	[	[	-LRB-
cord-334907-l4jjb93l	34	38	25	25	CD
cord-334907-l4jjb93l	34	39	]	]	-RRB-
cord-334907-l4jjb93l	34	40	.	.	.
cord-334907-l4jjb93l	35	1	In	in	IN
cord-334907-l4jjb93l	35	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	35	3	,	,	,
cord-334907-l4jjb93l	35	4	HE	he	PRP
cord-334907-l4jjb93l	35	5	contains	contain	VBZ
cord-334907-l4jjb93l	35	6	both	both	DT
cord-334907-l4jjb93l	35	7	receptor	receptor	NN
cord-334907-l4jjb93l	35	8	-	-	HYPH
cord-334907-l4jjb93l	35	9	binding	bind	VBG
cord-334907-l4jjb93l	35	10	and	and	CC
cord-334907-l4jjb93l	35	11	-destroying	-destroying	NN
cord-334907-l4jjb93l	35	12	activities	activity	NNS
cord-334907-l4jjb93l	35	13	,	,	,
cord-334907-l4jjb93l	35	14	with	with	IN
cord-334907-l4jjb93l	35	15	no	no	DT
cord-334907-l4jjb93l	35	16	apparent	apparent	JJ
cord-334907-l4jjb93l	35	17	influence	influence	NN
cord-334907-l4jjb93l	35	18	from	from	IN
cord-334907-l4jjb93l	35	19	the	the	DT
cord-334907-l4jjb93l	35	20	HPR	HPR	NNP
cord-334907-l4jjb93l	35	21	region	region	NN
cord-334907-l4jjb93l	35	22	over	over	IN
cord-334907-l4jjb93l	35	23	their	-PRON-	PRP$
cord-334907-l4jjb93l	35	24	equilibrium	equilibrium	NN
cord-334907-l4jjb93l	35	25	[	[	-LRB-
cord-334907-l4jjb93l	35	26	18	18	CD
cord-334907-l4jjb93l	35	27	]	]	-RRB-
cord-334907-l4jjb93l	35	28	.	.	.
cord-334907-l4jjb93l	36	1	Interaction	interaction	NN
cord-334907-l4jjb93l	36	2	of	of	IN
cord-334907-l4jjb93l	36	3	HA	HA	NNP
cord-334907-l4jjb93l	36	4	with	with	IN
cord-334907-l4jjb93l	36	5	a	a	DT
cord-334907-l4jjb93l	36	6	cellular	cellular	JJ
cord-334907-l4jjb93l	36	7	receptor	receptor	NN
cord-334907-l4jjb93l	36	8	is	be	VBZ
cord-334907-l4jjb93l	36	9	a	a	DT
cord-334907-l4jjb93l	36	10	key	key	JJ
cord-334907-l4jjb93l	36	11	step	step	NN
cord-334907-l4jjb93l	36	12	for	for	IN
cord-334907-l4jjb93l	36	13	the	the	DT
cord-334907-l4jjb93l	36	14	activation	activation	NN
cord-334907-l4jjb93l	36	15	of	of	IN
cord-334907-l4jjb93l	36	16	the	the	DT
cord-334907-l4jjb93l	36	17	fusion	fusion	NN
cord-334907-l4jjb93l	36	18	mechanism	mechanism	NN
cord-334907-l4jjb93l	36	19	in	in	IN
cord-334907-l4jjb93l	36	20	influenza	influenza	NN
cord-334907-l4jjb93l	36	21	[	[	-LRB-
cord-334907-l4jjb93l	36	22	26	26	CD
cord-334907-l4jjb93l	36	23	]	]	-RRB-
cord-334907-l4jjb93l	36	24	.	.	.
cord-334907-l4jjb93l	37	1	In	in	IN
cord-334907-l4jjb93l	37	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	37	3	,	,	,
cord-334907-l4jjb93l	37	4	no	no	DT
cord-334907-l4jjb93l	37	5	cellular	cellular	JJ
cord-334907-l4jjb93l	37	6	receptor	receptor	NN
cord-334907-l4jjb93l	37	7	has	have	VBZ
cord-334907-l4jjb93l	37	8	been	be	VBN
cord-334907-l4jjb93l	37	9	described	describe	VBN
cord-334907-l4jjb93l	37	10	for	for	IN
cord-334907-l4jjb93l	37	11	F	F	NNP
cord-334907-l4jjb93l	37	12	,	,	,
cord-334907-l4jjb93l	37	13	with	with	IN
cord-334907-l4jjb93l	37	14	HE	he	PRP
cord-334907-l4jjb93l	37	15	being	be	VBG
cord-334907-l4jjb93l	37	16	regarded	regard	VBN
cord-334907-l4jjb93l	37	17	as	as	RB
cord-334907-l4jjb93l	37	18	solely	solely	RB
cord-334907-l4jjb93l	37	19	responsible	responsible	JJ
cord-334907-l4jjb93l	37	20	for	for	IN
cord-334907-l4jjb93l	37	21	viral	viral	JJ
cord-334907-l4jjb93l	37	22	adhesion	adhesion	NN
cord-334907-l4jjb93l	37	23	to	to	IN
cord-334907-l4jjb93l	37	24	the	the	DT
cord-334907-l4jjb93l	37	25	cell	cell	NN
cord-334907-l4jjb93l	37	26	surface	surface	NN
cord-334907-l4jjb93l	37	27	[	[	-LRB-
cord-334907-l4jjb93l	37	28	10	10	CD
cord-334907-l4jjb93l	37	29	,	,	,
cord-334907-l4jjb93l	37	30	27	27	CD
cord-334907-l4jjb93l	37	31	,	,	,
cord-334907-l4jjb93l	37	32	28	28	CD
cord-334907-l4jjb93l	37	33	]	]	-RRB-
cord-334907-l4jjb93l	37	34	.	.	.
cord-334907-l4jjb93l	38	1	After	after	IN
cord-334907-l4jjb93l	38	2	proteolytic	proteolytic	JJ
cord-334907-l4jjb93l	38	3	cleavage	cleavage	NN
cord-334907-l4jjb93l	38	4	,	,	,
cord-334907-l4jjb93l	38	5	F	F	NNP
cord-334907-l4jjb93l	38	6	generates	generate	VBZ
cord-334907-l4jjb93l	38	7	two	two	CD
cord-334907-l4jjb93l	38	8	subunits	subunit	NNS
cord-334907-l4jjb93l	38	9	,	,	,
cord-334907-l4jjb93l	38	10	linked	link	VBN
cord-334907-l4jjb93l	38	11	by	by	IN
cord-334907-l4jjb93l	38	12	disulfide	disulfide	JJ
cord-334907-l4jjb93l	38	13	bridges	bridge	NNS
cord-334907-l4jjb93l	38	14	[	[	-LRB-
cord-334907-l4jjb93l	38	15	12	12	CD
cord-334907-l4jjb93l	38	16	]	]	-RRB-
cord-334907-l4jjb93l	38	17	.	.	.
cord-334907-l4jjb93l	39	1	The	the	DT
cord-334907-l4jjb93l	39	2	carboxy	carboxy	JJ
cord-334907-l4jjb93l	39	3	-	-	HYPH
cord-334907-l4jjb93l	39	4	terminal	terminal	NN
cord-334907-l4jjb93l	39	5	F	F	NNP
cord-334907-l4jjb93l	39	6	2	2	CD
cord-334907-l4jjb93l	39	7	,	,	,
cord-334907-l4jjb93l	39	8	contains	contain	VBZ
cord-334907-l4jjb93l	39	9	structural	structural	JJ
cord-334907-l4jjb93l	39	10	motifs	motif	NNS
cord-334907-l4jjb93l	39	11	typically	typically	RB
cord-334907-l4jjb93l	39	12	associated	associate	VBN
cord-334907-l4jjb93l	39	13	to	to	IN
cord-334907-l4jjb93l	39	14	fusion	fusion	NN
cord-334907-l4jjb93l	39	15	proteins	protein	NNS
cord-334907-l4jjb93l	39	16	[	[	-LRB-
cord-334907-l4jjb93l	39	17	13	13	CD
cord-334907-l4jjb93l	39	18	]	]	-RRB-
cord-334907-l4jjb93l	39	19	.	.	.
cord-334907-l4jjb93l	40	1	On	on	IN
cord-334907-l4jjb93l	40	2	the	the	DT
cord-334907-l4jjb93l	40	3	other	other	JJ
cord-334907-l4jjb93l	40	4	hand	hand	NN
cord-334907-l4jjb93l	40	5	,	,	,
cord-334907-l4jjb93l	40	6	no	no	DT
cord-334907-l4jjb93l	40	7	function	function	NN
cord-334907-l4jjb93l	40	8	has	have	VBZ
cord-334907-l4jjb93l	40	9	been	be	VBN
cord-334907-l4jjb93l	40	10	suggested	suggest	VBN
cord-334907-l4jjb93l	40	11	for	for	IN
cord-334907-l4jjb93l	40	12	the	the	DT
cord-334907-l4jjb93l	40	13	amino	amino	NN
cord-334907-l4jjb93l	40	14	-	-	HYPH
cord-334907-l4jjb93l	40	15	terminal	terminal	NN
cord-334907-l4jjb93l	40	16	F	F	NNP
cord-334907-l4jjb93l	40	17	1	1	CD
cord-334907-l4jjb93l	40	18	.	.	.
cord-334907-l4jjb93l	41	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	41	2	,	,	,
cord-334907-l4jjb93l	41	3	even	even	RB
cord-334907-l4jjb93l	41	4	though	though	IN
cord-334907-l4jjb93l	41	5	the	the	DT
cord-334907-l4jjb93l	41	6	fusion	fusion	NN
cord-334907-l4jjb93l	41	7	protein	protein	NN
cord-334907-l4jjb93l	41	8	from	from	IN
cord-334907-l4jjb93l	41	9	ISAV	ISAV	NNP
cord-334907-l4jjb93l	41	10	seems	seem	VBZ
cord-334907-l4jjb93l	41	11	incapable	incapable	JJ
cord-334907-l4jjb93l	41	12	of	of	IN
cord-334907-l4jjb93l	41	13	binding	bind	VBG
cord-334907-l4jjb93l	41	14	red	red	JJ
cord-334907-l4jjb93l	41	15	blood	blood	NN
cord-334907-l4jjb93l	41	16	cells	cell	NNS
cord-334907-l4jjb93l	41	17	(	(	-LRB-
cord-334907-l4jjb93l	41	18	RBCs	rbc	NNS
cord-334907-l4jjb93l	41	19	)	)	-RRB-
cord-334907-l4jjb93l	41	20	from	from	IN
cord-334907-l4jjb93l	41	21	salmon	salmon	NN
cord-334907-l4jjb93l	41	22	,	,	,
cord-334907-l4jjb93l	41	23	it	-PRON-	PRP
cord-334907-l4jjb93l	41	24	does	do	VBZ
cord-334907-l4jjb93l	41	25	retain	retain	VB
cord-334907-l4jjb93l	41	26	its	-PRON-	PRP$
cord-334907-l4jjb93l	41	27	fusion	fusion	NN
cord-334907-l4jjb93l	41	28	activity	activity	NN
cord-334907-l4jjb93l	41	29	in	in	IN
cord-334907-l4jjb93l	41	30	the	the	DT
cord-334907-l4jjb93l	41	31	absence	absence	NN
cord-334907-l4jjb93l	41	32	of	of	IN
cord-334907-l4jjb93l	41	33	an	an	DT
cord-334907-l4jjb93l	41	34	HE	HE	NNP
cord-334907-l4jjb93l	41	35	[	[	-LRB-
cord-334907-l4jjb93l	41	36	12	12	CD
cord-334907-l4jjb93l	41	37	]	]	-RRB-
cord-334907-l4jjb93l	41	38	.	.	.
cord-334907-l4jjb93l	42	1	Initial	initial	JJ
cord-334907-l4jjb93l	42	2	interactions	interaction	NNS
cord-334907-l4jjb93l	42	3	of	of	IN
cord-334907-l4jjb93l	42	4	viral	viral	JJ
cord-334907-l4jjb93l	42	5	particles	particle	NNS
cord-334907-l4jjb93l	42	6	with	with	IN
cord-334907-l4jjb93l	42	7	the	the	DT
cord-334907-l4jjb93l	42	8	cell	cell	NN
cord-334907-l4jjb93l	42	9	are	be	VBP
cord-334907-l4jjb93l	42	10	highly	highly	RB
cord-334907-l4jjb93l	42	11	important	important	JJ
cord-334907-l4jjb93l	42	12	for	for	IN
cord-334907-l4jjb93l	42	13	infection	infection	NN
cord-334907-l4jjb93l	42	14	,	,	,
cord-334907-l4jjb93l	42	15	with	with	IN
cord-334907-l4jjb93l	42	16	fusion	fusion	NN
cord-334907-l4jjb93l	42	17	of	of	IN
cord-334907-l4jjb93l	42	18	the	the	DT
cord-334907-l4jjb93l	42	19	viral	viral	JJ
cord-334907-l4jjb93l	42	20	and	and	CC
cord-334907-l4jjb93l	42	21	cellular	cellular	JJ
cord-334907-l4jjb93l	42	22	membranes	membrane	NNS
cord-334907-l4jjb93l	42	23	being	be	VBG
cord-334907-l4jjb93l	42	24	a	a	DT
cord-334907-l4jjb93l	42	25	key	key	JJ
cord-334907-l4jjb93l	42	26	step	step	NN
cord-334907-l4jjb93l	42	27	.	.	.
cord-334907-l4jjb93l	43	1	Viral	viral	JJ
cord-334907-l4jjb93l	43	2	surface	surface	NN
cord-334907-l4jjb93l	43	3	proteins	protein	NNS
cord-334907-l4jjb93l	43	4	and	and	CC
cord-334907-l4jjb93l	43	5	cell	cell	NN
cord-334907-l4jjb93l	43	6	glycome	glycome	NNP
cord-334907-l4jjb93l	43	7	diversity	diversity	NN
cord-334907-l4jjb93l	43	8	are	be	VBP
cord-334907-l4jjb93l	43	9	crucial	crucial	JJ
cord-334907-l4jjb93l	43	10	elements	element	NNS
cord-334907-l4jjb93l	43	11	regulating	regulate	VBG
cord-334907-l4jjb93l	43	12	virulence	virulence	NN
cord-334907-l4jjb93l	43	13	and	and	CC
cord-334907-l4jjb93l	43	14	tropism	tropism	NN
cord-334907-l4jjb93l	43	15	[	[	-LRB-
cord-334907-l4jjb93l	43	16	29	29	CD
cord-334907-l4jjb93l	43	17	,	,	,
cord-334907-l4jjb93l	43	18	30	30	CD
cord-334907-l4jjb93l	43	19	]	]	-RRB-
cord-334907-l4jjb93l	43	20	.	.	.
cord-334907-l4jjb93l	44	1	Receptor	receptor	NN
cord-334907-l4jjb93l	44	2	-	-	HYPH
cord-334907-l4jjb93l	44	3	binding	bind	VBG
cord-334907-l4jjb93l	44	4	,	,	,
cord-334907-l4jjb93l	44	5	receptor	receptor	NN
cord-334907-l4jjb93l	44	6	-	-	HYPH
cord-334907-l4jjb93l	44	7	destroying	destroy	VBG
cord-334907-l4jjb93l	44	8	,	,	,
cord-334907-l4jjb93l	44	9	and	and	CC
cord-334907-l4jjb93l	44	10	membrane	membrane	NN
cord-334907-l4jjb93l	44	11	fusion	fusion	NN
cord-334907-l4jjb93l	44	12	activities	activity	NNS
cord-334907-l4jjb93l	44	13	have	have	VBP
cord-334907-l4jjb93l	44	14	a	a	DT
cord-334907-l4jjb93l	44	15	unique	unique	JJ
cord-334907-l4jjb93l	44	16	distribution	distribution	NN
cord-334907-l4jjb93l	44	17	in	in	IN
cord-334907-l4jjb93l	44	18	ISAV	ISAV	NNP
cord-334907-l4jjb93l	44	19	,	,	,
cord-334907-l4jjb93l	44	20	compared	compare	VBN
cord-334907-l4jjb93l	44	21	to	to	IN
cord-334907-l4jjb93l	44	22	other	other	JJ
cord-334907-l4jjb93l	44	23	orthomyxovirus	orthomyxovirus	NN
cord-334907-l4jjb93l	44	24	;	;	:
cord-334907-l4jjb93l	44	25	moreover	moreover	RB
cord-334907-l4jjb93l	44	26	,	,	,
cord-334907-l4jjb93l	44	27	HE	HE	NNP
cord-334907-l4jjb93l	44	28	HPR	HPR	NNP
cord-334907-l4jjb93l	44	29	length	length	NN
cord-334907-l4jjb93l	44	30	variation	variation	NN
cord-334907-l4jjb93l	44	31	represents	represent	VBZ
cord-334907-l4jjb93l	44	32	a	a	DT
cord-334907-l4jjb93l	44	33	novel	novel	JJ
cord-334907-l4jjb93l	44	34	mechanism	mechanism	NN
cord-334907-l4jjb93l	44	35	for	for	IN
cord-334907-l4jjb93l	44	36	fusion	fusion	NN
cord-334907-l4jjb93l	44	37	activity	activity	NN
cord-334907-l4jjb93l	44	38	and	and	CC
cord-334907-l4jjb93l	44	39	virulence	virulence	NN
cord-334907-l4jjb93l	44	40	regulation	regulation	NN
cord-334907-l4jjb93l	44	41	.	.	.
cord-334907-l4jjb93l	45	1	In	in	IN
cord-334907-l4jjb93l	45	2	this	this	DT
cord-334907-l4jjb93l	45	3	context	context	NN
cord-334907-l4jjb93l	45	4	,	,	,
cord-334907-l4jjb93l	45	5	interaction	interaction	NN
cord-334907-l4jjb93l	45	6	of	of	IN
cord-334907-l4jjb93l	45	7	F	F	NNP
cord-334907-l4jjb93l	45	8	with	with	IN
cord-334907-l4jjb93l	45	9	a	a	DT
cord-334907-l4jjb93l	45	10	cell	cell	NN
cord-334907-l4jjb93l	45	11	receptor	receptor	NN
cord-334907-l4jjb93l	45	12	,	,	,
cord-334907-l4jjb93l	45	13	with	with	IN
cord-334907-l4jjb93l	45	14	regulation	regulation	NN
cord-334907-l4jjb93l	45	15	of	of	IN
cord-334907-l4jjb93l	45	16	the	the	DT
cord-334907-l4jjb93l	45	17	esterase	esterase	NN
cord-334907-l4jjb93l	45	18	activity	activity	NN
cord-334907-l4jjb93l	45	19	over	over	IN
cord-334907-l4jjb93l	45	20	this	this	DT
cord-334907-l4jjb93l	45	21	receptor	receptor	NN
cord-334907-l4jjb93l	45	22	via	via	IN
cord-334907-l4jjb93l	45	23	HPR	HPR	NNP
cord-334907-l4jjb93l	45	24	length	length	NN
cord-334907-l4jjb93l	45	25	,	,	,
cord-334907-l4jjb93l	45	26	represents	represent	VBZ
cord-334907-l4jjb93l	45	27	a	a	DT
cord-334907-l4jjb93l	45	28	feasible	feasible	JJ
cord-334907-l4jjb93l	45	29	explanation	explanation	NN
cord-334907-l4jjb93l	45	30	for	for	IN
cord-334907-l4jjb93l	45	31	the	the	DT
cord-334907-l4jjb93l	45	32	differential	differential	JJ
cord-334907-l4jjb93l	45	33	activities	activity	NNS
cord-334907-l4jjb93l	45	34	described	describe	VBN
cord-334907-l4jjb93l	45	35	for	for	IN
cord-334907-l4jjb93l	45	36	the	the	DT
cord-334907-l4jjb93l	45	37	HPR0	HPR0	NNP
cord-334907-l4jjb93l	45	38	and	and	CC
cord-334907-l4jjb93l	45	39	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	45	40	fusion	fusion	NN
cord-334907-l4jjb93l	45	41	systems	system	NNS
cord-334907-l4jjb93l	45	42	.	.	.
cord-334907-l4jjb93l	46	1	In	in	IN
cord-334907-l4jjb93l	46	2	this	this	DT
cord-334907-l4jjb93l	46	3	study	study	NN
cord-334907-l4jjb93l	46	4	,	,	,
cord-334907-l4jjb93l	46	5	we	-PRON-	PRP
cord-334907-l4jjb93l	46	6	aimed	aim	VBD
cord-334907-l4jjb93l	46	7	to	to	TO
cord-334907-l4jjb93l	46	8	determine	determine	VB
cord-334907-l4jjb93l	46	9	the	the	DT
cord-334907-l4jjb93l	46	10	role	role	NN
cord-334907-l4jjb93l	46	11	of	of	IN
cord-334907-l4jjb93l	46	12	the	the	DT
cord-334907-l4jjb93l	46	13	F	F	NNP
cord-334907-l4jjb93l	46	14	1	1	CD
cord-334907-l4jjb93l	46	15	domain	domain	NN
cord-334907-l4jjb93l	46	16	in	in	IN
cord-334907-l4jjb93l	46	17	the	the	DT
cord-334907-l4jjb93l	46	18	activity	activity	NN
cord-334907-l4jjb93l	46	19	of	of	IN
cord-334907-l4jjb93l	46	20	the	the	DT
cord-334907-l4jjb93l	46	21	fusion	fusion	NN
cord-334907-l4jjb93l	46	22	protein	protein	NN
cord-334907-l4jjb93l	46	23	.	.	.
cord-334907-l4jjb93l	47	1	Due	due	IN
cord-334907-l4jjb93l	47	2	to	to	IN
cord-334907-l4jjb93l	47	3	the	the	DT
cord-334907-l4jjb93l	47	4	lack	lack	NN
cord-334907-l4jjb93l	47	5	of	of	IN
cord-334907-l4jjb93l	47	6	a	a	DT
cord-334907-l4jjb93l	47	7	crystal	crystal	NN
cord-334907-l4jjb93l	47	8	structure	structure	NN
cord-334907-l4jjb93l	47	9	,	,	,
cord-334907-l4jjb93l	47	10	and	and	CC
cord-334907-l4jjb93l	47	11	robust	robust	JJ
cord-334907-l4jjb93l	47	12	sequence	sequence	NN
cord-334907-l4jjb93l	47	13	homology	homology	NN
cord-334907-l4jjb93l	47	14	to	to	IN
cord-334907-l4jjb93l	47	15	other	other	JJ
cord-334907-l4jjb93l	47	16	species	specie	NNS
cord-334907-l4jjb93l	47	17	,	,	,
cord-334907-l4jjb93l	47	18	we	-PRON-	PRP
cord-334907-l4jjb93l	47	19	based	base	VBD
cord-334907-l4jjb93l	47	20	our	-PRON-	PRP$
cord-334907-l4jjb93l	47	21	analysis	analysis	NN
cord-334907-l4jjb93l	47	22	on	on	IN
cord-334907-l4jjb93l	47	23	secondary	secondary	JJ
cord-334907-l4jjb93l	47	24	structure	structure	NN
cord-334907-l4jjb93l	47	25	homology	homology	NN
cord-334907-l4jjb93l	47	26	and	and	CC
cord-334907-l4jjb93l	47	27	propose	propose	VB
cord-334907-l4jjb93l	47	28	a	a	DT
cord-334907-l4jjb93l	47	29	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	47	30	-	-	HYPH
cord-334907-l4jjb93l	47	31	like	like	JJ
cord-334907-l4jjb93l	47	32	structure	structure	NN
cord-334907-l4jjb93l	47	33	for	for	IN
cord-334907-l4jjb93l	47	34	F	F	NNP
cord-334907-l4jjb93l	47	35	1	1	CD
cord-334907-l4jjb93l	47	36	,	,	,
cord-334907-l4jjb93l	47	37	suggesting	suggest	VBG
cord-334907-l4jjb93l	47	38	a	a	DT
cord-334907-l4jjb93l	47	39	receptor	receptor	NN
cord-334907-l4jjb93l	47	40	-	-	HYPH
cord-334907-l4jjb93l	47	41	binding	bind	VBG
cord-334907-l4jjb93l	47	42	activity	activity	NN
cord-334907-l4jjb93l	47	43	for	for	IN
cord-334907-l4jjb93l	47	44	this	this	DT
cord-334907-l4jjb93l	47	45	domain	domain	NN
cord-334907-l4jjb93l	47	46	.	.	.
cord-334907-l4jjb93l	48	1	We	-PRON-	PRP
cord-334907-l4jjb93l	48	2	demonstrate	demonstrate	VBP
cord-334907-l4jjb93l	48	3	the	the	DT
cord-334907-l4jjb93l	48	4	interaction	interaction	NN
cord-334907-l4jjb93l	48	5	of	of	IN
cord-334907-l4jjb93l	48	6	the	the	DT
cord-334907-l4jjb93l	48	7	F	F	NNP
cord-334907-l4jjb93l	48	8	protein	protein	NN
cord-334907-l4jjb93l	48	9	of	of	IN
cord-334907-l4jjb93l	48	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	48	11	with	with	IN
cord-334907-l4jjb93l	48	12	a	a	DT
cord-334907-l4jjb93l	48	13	cellular	cellular	JJ
cord-334907-l4jjb93l	48	14	receptor	receptor	NN
cord-334907-l4jjb93l	48	15	,	,	,
cord-334907-l4jjb93l	48	16	probably	probably	RB
cord-334907-l4jjb93l	48	17	a	a	DT
cord-334907-l4jjb93l	48	18	carbohydrate	carbohydrate	NN
cord-334907-l4jjb93l	48	19	motif	motif	NN
cord-334907-l4jjb93l	48	20	,	,	,
cord-334907-l4jjb93l	48	21	and	and	CC
cord-334907-l4jjb93l	48	22	the	the	DT
cord-334907-l4jjb93l	48	23	importance	importance	NN
cord-334907-l4jjb93l	48	24	of	of	IN
cord-334907-l4jjb93l	48	25	F	F	NNP
cord-334907-l4jjb93l	48	26	1	1	CD
cord-334907-l4jjb93l	48	27	for	for	IN
cord-334907-l4jjb93l	48	28	the	the	DT
cord-334907-l4jjb93l	48	29	fusion	fusion	NN
cord-334907-l4jjb93l	48	30	process	process	NN
cord-334907-l4jjb93l	48	31	.	.	.
cord-334907-l4jjb93l	49	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	49	2	,	,	,
cord-334907-l4jjb93l	49	3	the	the	DT
cord-334907-l4jjb93l	49	4	HE	HE	NNP
cord-334907-l4jjb93l	49	5	esterase	esterase	NN
cord-334907-l4jjb93l	49	6	has	have	VBZ
cord-334907-l4jjb93l	49	7	an	an	DT
cord-334907-l4jjb93l	49	8	effect	effect	NN
cord-334907-l4jjb93l	49	9	over	over	IN
cord-334907-l4jjb93l	49	10	the	the	DT
cord-334907-l4jjb93l	49	11	interaction	interaction	NN
cord-334907-l4jjb93l	49	12	of	of	IN
cord-334907-l4jjb93l	49	13	F	F	NNP
cord-334907-l4jjb93l	49	14	with	with	IN
cord-334907-l4jjb93l	49	15	its	-PRON-	PRP$
cord-334907-l4jjb93l	49	16	receptor	receptor	NN
cord-334907-l4jjb93l	49	17	,	,	,
cord-334907-l4jjb93l	49	18	which	which	WDT
cord-334907-l4jjb93l	49	19	further	further	RB
cord-334907-l4jjb93l	49	20	narrows	narrow	VBZ
cord-334907-l4jjb93l	49	21	down	down	IN
cord-334907-l4jjb93l	49	22	the	the	DT
cord-334907-l4jjb93l	49	23	chemical	chemical	JJ
cord-334907-l4jjb93l	49	24	identity	identity	NN
cord-334907-l4jjb93l	49	25	of	of	IN
cord-334907-l4jjb93l	49	26	the	the	DT
cord-334907-l4jjb93l	49	27	receptor	receptor	NN
cord-334907-l4jjb93l	49	28	and	and	CC
cord-334907-l4jjb93l	49	29	suggest	suggest	VB
cord-334907-l4jjb93l	49	30	a	a	DT
cord-334907-l4jjb93l	49	31	regulatory	regulatory	JJ
cord-334907-l4jjb93l	49	32	role	role	NN
cord-334907-l4jjb93l	49	33	for	for	IN
cord-334907-l4jjb93l	49	34	HE	he	PRP
cord-334907-l4jjb93l	49	35	not	not	RB
cord-334907-l4jjb93l	49	36	only	only	RB
cord-334907-l4jjb93l	49	37	in	in	IN
cord-334907-l4jjb93l	49	38	the	the	DT
cord-334907-l4jjb93l	49	39	adhesion	adhesion	NN
cord-334907-l4jjb93l	49	40	but	but	CC
cord-334907-l4jjb93l	49	41	also	also	RB
cord-334907-l4jjb93l	49	42	in	in	IN
cord-334907-l4jjb93l	49	43	the	the	DT
cord-334907-l4jjb93l	49	44	fusion	fusion	NN
cord-334907-l4jjb93l	49	45	mechanism	mechanism	NN
cord-334907-l4jjb93l	49	46	of	of	IN
cord-334907-l4jjb93l	49	47	ISAV	ISAV	NNP
cord-334907-l4jjb93l	49	48	.	.	.
cord-334907-l4jjb93l	50	1	Finally	finally	RB
cord-334907-l4jjb93l	50	2	,	,	,
cord-334907-l4jjb93l	50	3	we	-PRON-	PRP
cord-334907-l4jjb93l	50	4	propose	propose	VBP
cord-334907-l4jjb93l	50	5	a	a	DT
cord-334907-l4jjb93l	50	6	model	model	NN
cord-334907-l4jjb93l	50	7	where	where	WRB
cord-334907-l4jjb93l	50	8	the	the	DT
cord-334907-l4jjb93l	50	9	stalk	stalk	NN
cord-334907-l4jjb93l	50	10	length	length	NN
cord-334907-l4jjb93l	50	11	in	in	IN
cord-334907-l4jjb93l	50	12	HE	he	PRP
cord-334907-l4jjb93l	50	13	modulates	modulate	VBZ
cord-334907-l4jjb93l	50	14	the	the	DT
cord-334907-l4jjb93l	50	15	activity	activity	NN
cord-334907-l4jjb93l	50	16	of	of	IN
cord-334907-l4jjb93l	50	17	the	the	DT
cord-334907-l4jjb93l	50	18	viral	viral	JJ
cord-334907-l4jjb93l	50	19	esterase	esterase	NN
cord-334907-l4jjb93l	50	20	over	over	IN
cord-334907-l4jjb93l	50	21	the	the	DT
cord-334907-l4jjb93l	50	22	putative	putative	JJ
cord-334907-l4jjb93l	50	23	F	F	NNP
cord-334907-l4jjb93l	50	24	receptor	receptor	NN
cord-334907-l4jjb93l	50	25	and	and	CC
cord-334907-l4jjb93l	50	26	consequently	consequently	RB
cord-334907-l4jjb93l	50	27	over	over	IN
cord-334907-l4jjb93l	50	28	the	the	DT
cord-334907-l4jjb93l	50	29	fusion	fusion	NN
cord-334907-l4jjb93l	50	30	process	process	NN
cord-334907-l4jjb93l	50	31	.	.	.
cord-334907-l4jjb93l	51	1	These	these	DT
cord-334907-l4jjb93l	51	2	results	result	NNS
cord-334907-l4jjb93l	51	3	demonstrate	demonstrate	VBP
cord-334907-l4jjb93l	51	4	the	the	DT
cord-334907-l4jjb93l	51	5	important	important	JJ
cord-334907-l4jjb93l	51	6	role	role	NN
cord-334907-l4jjb93l	51	7	of	of	IN
cord-334907-l4jjb93l	51	8	viral	viral	JJ
cord-334907-l4jjb93l	51	9	surface	surface	NN
cord-334907-l4jjb93l	51	10	proteins	protein	NNS
cord-334907-l4jjb93l	51	11	in	in	IN
cord-334907-l4jjb93l	51	12	the	the	DT
cord-334907-l4jjb93l	51	13	regulation	regulation	NN
cord-334907-l4jjb93l	51	14	of	of	IN
cord-334907-l4jjb93l	51	15	infectivity	infectivity	NN
cord-334907-l4jjb93l	51	16	;	;	:
cord-334907-l4jjb93l	51	17	in	in	IN
cord-334907-l4jjb93l	51	18	particular	particular	JJ
cord-334907-l4jjb93l	51	19	,	,	,
cord-334907-l4jjb93l	51	20	they	-PRON-	PRP
cord-334907-l4jjb93l	51	21	may	may	MD
cord-334907-l4jjb93l	51	22	further	further	RB
cord-334907-l4jjb93l	51	23	define	define	VB
cord-334907-l4jjb93l	51	24	the	the	DT
cord-334907-l4jjb93l	51	25	influence	influence	NN
cord-334907-l4jjb93l	51	26	of	of	IN
cord-334907-l4jjb93l	51	27	HPR	HPR	NNP
cord-334907-l4jjb93l	51	28	on	on	IN
cord-334907-l4jjb93l	51	29	the	the	DT
cord-334907-l4jjb93l	51	30	fusion	fusion	NN
cord-334907-l4jjb93l	51	31	activity	activity	NN
cord-334907-l4jjb93l	51	32	in	in	IN
cord-334907-l4jjb93l	51	33	ISAV	ISAV	NNP
cord-334907-l4jjb93l	51	34	,	,	,
cord-334907-l4jjb93l	51	35	suggesting	suggest	VBG
cord-334907-l4jjb93l	51	36	a	a	DT
cord-334907-l4jjb93l	51	37	novel	novel	JJ
cord-334907-l4jjb93l	51	38	role	role	NN
cord-334907-l4jjb93l	51	39	for	for	IN
cord-334907-l4jjb93l	51	40	F	F	NNP
cord-334907-l4jjb93l	51	41	(	(	-LRB-
cord-334907-l4jjb93l	51	42	i.e.	i.e.	FW
cord-334907-l4jjb93l	51	43	,	,	,
cord-334907-l4jjb93l	51	44	receptor	receptor	NN
cord-334907-l4jjb93l	51	45	interaction	interaction	NN
cord-334907-l4jjb93l	51	46	)	)	-RRB-
cord-334907-l4jjb93l	51	47	.	.	.
cord-334907-l4jjb93l	52	1	Finally	finally	RB
cord-334907-l4jjb93l	52	2	,	,	,
cord-334907-l4jjb93l	52	3	these	these	DT
cord-334907-l4jjb93l	52	4	results	result	NNS
cord-334907-l4jjb93l	52	5	offer	offer	VBP
cord-334907-l4jjb93l	52	6	new	new	JJ
cord-334907-l4jjb93l	52	7	insights	insight	NNS
cord-334907-l4jjb93l	52	8	into	into	IN
cord-334907-l4jjb93l	52	9	the	the	DT
cord-334907-l4jjb93l	52	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	52	11	fusion	fusion	NN
cord-334907-l4jjb93l	52	12	system	system	NN
cord-334907-l4jjb93l	52	13	,	,	,
cord-334907-l4jjb93l	52	14	and	and	CC
cord-334907-l4jjb93l	52	15	the	the	DT
cord-334907-l4jjb93l	52	16	directly	directly	RB
cord-334907-l4jjb93l	52	17	related	relate	VBN
cord-334907-l4jjb93l	52	18	infectivity	infectivity	NN
cord-334907-l4jjb93l	52	19	,	,	,
cord-334907-l4jjb93l	52	20	aiming	aim	VBG
cord-334907-l4jjb93l	52	21	to	to	TO
cord-334907-l4jjb93l	52	22	provide	provide	VB
cord-334907-l4jjb93l	52	23	a	a	DT
cord-334907-l4jjb93l	52	24	better	well	JJR
cord-334907-l4jjb93l	52	25	understanding	understanding	NN
cord-334907-l4jjb93l	52	26	of	of	IN
cord-334907-l4jjb93l	52	27	the	the	DT
cord-334907-l4jjb93l	52	28	viral	viral	JJ
cord-334907-l4jjb93l	52	29	behavior	behavior	NN
cord-334907-l4jjb93l	52	30	.	.	.
cord-334907-l4jjb93l	52	31	 	 	_SP
cord-334907-l4jjb93l	53	1	The	the	DT
cord-334907-l4jjb93l	53	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	53	3	F	F	NNP
cord-334907-l4jjb93l	53	4	carboxyl	carboxyl	NN
cord-334907-l4jjb93l	53	5	-	-	HYPH
cord-334907-l4jjb93l	53	6	end	end	NN
cord-334907-l4jjb93l	53	7	sequence	sequence	NN
cord-334907-l4jjb93l	53	8	contains	contain	VBZ
cord-334907-l4jjb93l	53	9	canonical	canonical	JJ
cord-334907-l4jjb93l	53	10	features	feature	NNS
cord-334907-l4jjb93l	53	11	of	of	IN
cord-334907-l4jjb93l	53	12	a	a	DT
cord-334907-l4jjb93l	53	13	type	type	NN
cord-334907-l4jjb93l	53	14	I	-PRON-	PRP
cord-334907-l4jjb93l	53	15	fusion	fusion	NN
cord-334907-l4jjb93l	53	16	protein	protein	NN
cord-334907-l4jjb93l	53	17	,	,	,
cord-334907-l4jjb93l	53	18	and	and	CC
cord-334907-l4jjb93l	53	19	its	-PRON-	PRP$
cord-334907-l4jjb93l	53	20	characteristics	characteristic	NNS
cord-334907-l4jjb93l	53	21	have	have	VBP
cord-334907-l4jjb93l	53	22	already	already	RB
cord-334907-l4jjb93l	53	23	been	be	VBN
cord-334907-l4jjb93l	53	24	thoroughly	thoroughly	RB
cord-334907-l4jjb93l	53	25	analyzed	analyze	VBN
cord-334907-l4jjb93l	53	26	[	[	-LRB-
cord-334907-l4jjb93l	53	27	12	12	CD
cord-334907-l4jjb93l	53	28	,	,	,
cord-334907-l4jjb93l	53	29	31	31	CD
cord-334907-l4jjb93l	53	30	]	]	-RRB-
cord-334907-l4jjb93l	53	31	.	.	.
cord-334907-l4jjb93l	54	1	Furthermore	furthermore	RB
cord-334907-l4jjb93l	54	2	,	,	,
cord-334907-l4jjb93l	54	3	the	the	DT
cord-334907-l4jjb93l	54	4	structure	structure	NN
cord-334907-l4jjb93l	54	5	of	of	IN
cord-334907-l4jjb93l	54	6	the	the	DT
cord-334907-l4jjb93l	54	7	fusion	fusion	NN
cord-334907-l4jjb93l	54	8	core	core	NN
cord-334907-l4jjb93l	54	9	has	have	VBZ
cord-334907-l4jjb93l	54	10	been	be	VBN
cord-334907-l4jjb93l	54	11	resolved	resolve	VBN
cord-334907-l4jjb93l	54	12	,	,	,
cord-334907-l4jjb93l	54	13	allowing	allow	VBG
cord-334907-l4jjb93l	54	14	for	for	IN
cord-334907-l4jjb93l	54	15	robust	robust	JJ
cord-334907-l4jjb93l	54	16	definition	definition	NN
cord-334907-l4jjb93l	54	17	of	of	IN
cord-334907-l4jjb93l	54	18	the	the	DT
cord-334907-l4jjb93l	54	19	two	two	CD
cord-334907-l4jjb93l	54	20	protein	protein	NN
cord-334907-l4jjb93l	54	21	domains	domain	NNS
cord-334907-l4jjb93l	54	22	:	:	:
cord-334907-l4jjb93l	54	23	a	a	DT
cord-334907-l4jjb93l	54	24	carboxy	carboxy	JJ
cord-334907-l4jjb93l	54	25	-	-	HYPH
cord-334907-l4jjb93l	54	26	terminal	terminal	NN
cord-334907-l4jjb93l	54	27	(	(	-LRB-
cord-334907-l4jjb93l	54	28	F	F	NNP
cord-334907-l4jjb93l	54	29	2	2	CD
cord-334907-l4jjb93l	54	30	)	)	-RRB-
cord-334907-l4jjb93l	54	31	,	,	,
cord-334907-l4jjb93l	54	32	containing	contain	VBG
cord-334907-l4jjb93l	54	33	the	the	DT
cord-334907-l4jjb93l	54	34	transmembrane	transmembrane	NN
cord-334907-l4jjb93l	54	35	domain	domain	NN
cord-334907-l4jjb93l	54	36	,	,	,
cord-334907-l4jjb93l	54	37	a	a	DT
cord-334907-l4jjb93l	54	38	coiled	coiled	JJ
cord-334907-l4jjb93l	54	39	coil	coil	NN
cord-334907-l4jjb93l	54	40	region	region	NN
cord-334907-l4jjb93l	54	41	,	,	,
cord-334907-l4jjb93l	54	42	and	and	CC
cord-334907-l4jjb93l	54	43	a	a	DT
cord-334907-l4jjb93l	54	44	fusion	fusion	NN
cord-334907-l4jjb93l	54	45	peptide	peptide	NN
cord-334907-l4jjb93l	54	46	,	,	,
cord-334907-l4jjb93l	54	47	and	and	CC
cord-334907-l4jjb93l	54	48	an	an	DT
cord-334907-l4jjb93l	54	49	amino	amino	NN
cord-334907-l4jjb93l	54	50	-	-	HYPH
cord-334907-l4jjb93l	54	51	terminal	terminal	NN
cord-334907-l4jjb93l	54	52	domain	domain	NN
cord-334907-l4jjb93l	54	53	(	(	-LRB-
cord-334907-l4jjb93l	54	54	F	F	NNP
cord-334907-l4jjb93l	54	55	1	1	CD
cord-334907-l4jjb93l	54	56	)	)	-RRB-
cord-334907-l4jjb93l	54	57	,	,	,
cord-334907-l4jjb93l	54	58	of	of	IN
cord-334907-l4jjb93l	54	59	undefined	undefined	JJ
cord-334907-l4jjb93l	54	60	tertiary	tertiary	JJ
cord-334907-l4jjb93l	54	61	structure	structure	NN
cord-334907-l4jjb93l	54	62	and	and	CC
cord-334907-l4jjb93l	54	63	function	function	NN
cord-334907-l4jjb93l	54	64	[	[	-LRB-
cord-334907-l4jjb93l	54	65	13	13	CD
cord-334907-l4jjb93l	54	66	]	]	-RRB-
cord-334907-l4jjb93l	54	67	.	.	.
cord-334907-l4jjb93l	55	1	Due	due	IN
cord-334907-l4jjb93l	55	2	to	to	IN
cord-334907-l4jjb93l	55	3	the	the	DT
cord-334907-l4jjb93l	55	4	lack	lack	NN
cord-334907-l4jjb93l	55	5	of	of	IN
cord-334907-l4jjb93l	55	6	a	a	DT
cord-334907-l4jjb93l	55	7	crystal	crystal	NN
cord-334907-l4jjb93l	55	8	structure	structure	NN
cord-334907-l4jjb93l	55	9	and	and	CC
cord-334907-l4jjb93l	55	10	robust	robust	JJ
cord-334907-l4jjb93l	55	11	sequence	sequence	NN
cord-334907-l4jjb93l	55	12	homology	homology	NN
cord-334907-l4jjb93l	55	13	to	to	IN
cord-334907-l4jjb93l	55	14	proteins	protein	NNS
cord-334907-l4jjb93l	55	15	from	from	IN
cord-334907-l4jjb93l	55	16	other	other	JJ
cord-334907-l4jjb93l	55	17	species	specie	NNS
cord-334907-l4jjb93l	55	18	for	for	IN
cord-334907-l4jjb93l	55	19	the	the	DT
cord-334907-l4jjb93l	55	20	amino	amino	NN
cord-334907-l4jjb93l	55	21	-	-	HYPH
cord-334907-l4jjb93l	55	22	terminal	terminal	NN
cord-334907-l4jjb93l	55	23	domain	domain	NN
cord-334907-l4jjb93l	55	24	of	of	IN
cord-334907-l4jjb93l	55	25	F	F	NNP
cord-334907-l4jjb93l	55	26	,	,	,
cord-334907-l4jjb93l	55	27	we	-PRON-	PRP
cord-334907-l4jjb93l	55	28	aimed	aim	VBD
cord-334907-l4jjb93l	55	29	to	to	TO
cord-334907-l4jjb93l	55	30	develop	develop	VB
cord-334907-l4jjb93l	55	31	a	a	DT
cord-334907-l4jjb93l	55	32	structural	structural	JJ
cord-334907-l4jjb93l	55	33	model	model	NN
cord-334907-l4jjb93l	55	34	for	for	IN
cord-334907-l4jjb93l	55	35	this	this	DT
cord-334907-l4jjb93l	55	36	subdomain	subdomain	NN
cord-334907-l4jjb93l	55	37	.	.	.
cord-334907-l4jjb93l	56	1	A	a	DT
cord-334907-l4jjb93l	56	2	secondary	secondary	JJ
cord-334907-l4jjb93l	56	3	structure	structure	NN
cord-334907-l4jjb93l	56	4	analysis	analysis	NN
cord-334907-l4jjb93l	56	5	of	of	IN
cord-334907-l4jjb93l	56	6	the	the	DT
cord-334907-l4jjb93l	56	7	amino	amino	NN
cord-334907-l4jjb93l	56	8	acid	acid	NN
cord-334907-l4jjb93l	56	9	sequence	sequence	NN
cord-334907-l4jjb93l	56	10	for	for	IN
cord-334907-l4jjb93l	56	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	56	12	F	F	NNP
cord-334907-l4jjb93l	56	13	revealed	reveal	VBD
cord-334907-l4jjb93l	56	14	a	a	DT
cord-334907-l4jjb93l	56	15	high	high	JJ
cord-334907-l4jjb93l	56	16	content	content	NN
cord-334907-l4jjb93l	56	17	of	of	IN
cord-334907-l4jjb93l	56	18	beta	beta	JJ
cord-334907-l4jjb93l	56	19	strands	strand	NNS
cord-334907-l4jjb93l	56	20	for	for	IN
cord-334907-l4jjb93l	56	21	the	the	DT
cord-334907-l4jjb93l	56	22	F	F	NNP
cord-334907-l4jjb93l	56	23	1	1	CD
cord-334907-l4jjb93l	56	24	subunit	subunit	NN
cord-334907-l4jjb93l	56	25	,	,	,
cord-334907-l4jjb93l	56	26	with	with	IN
cord-334907-l4jjb93l	56	27	this	this	DT
cord-334907-l4jjb93l	56	28	topology	topology	NN
cord-334907-l4jjb93l	56	29	being	be	VBG
cord-334907-l4jjb93l	56	30	characteristic	characteristic	JJ
cord-334907-l4jjb93l	56	31	of	of	IN
cord-334907-l4jjb93l	56	32	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	56	33	domains	domain	NNS
cord-334907-l4jjb93l	56	34	[	[	-LRB-
cord-334907-l4jjb93l	56	35	32	32	CD
cord-334907-l4jjb93l	56	36	]	]	-RRB-
cord-334907-l4jjb93l	56	37	(	(	-LRB-
cord-334907-l4jjb93l	56	38	Figure	figure	NN
cord-334907-l4jjb93l	56	39	1	1	CD
cord-334907-l4jjb93l	56	40	)	)	-RRB-
cord-334907-l4jjb93l	56	41	.	.	.
cord-334907-l4jjb93l	57	1	Considering	consider	VBG
cord-334907-l4jjb93l	57	2	that	that	IN
cord-334907-l4jjb93l	57	3	the	the	DT
cord-334907-l4jjb93l	57	4	F	F	NNP
cord-334907-l4jjb93l	57	5	2	2	CD
cord-334907-l4jjb93l	57	6	domain	domain	NN
cord-334907-l4jjb93l	57	7	resembles	resemble	VBZ
cord-334907-l4jjb93l	57	8	the	the	DT
cord-334907-l4jjb93l	57	9	carboxy	carboxy	JJ
cord-334907-l4jjb93l	57	10	-	-	HYPH
cord-334907-l4jjb93l	57	11	terminal	terminal	NN
cord-334907-l4jjb93l	57	12	domain	domain	NN
cord-334907-l4jjb93l	57	13	of	of	IN
cord-334907-l4jjb93l	57	14	influenza	influenza	NN
cord-334907-l4jjb93l	57	15	virus	virus	NN
cord-334907-l4jjb93l	58	1	A	a	DT
cord-334907-l4jjb93l	58	2	HA	HA	NNP
cord-334907-l4jjb93l	58	3	and	and	CC
cord-334907-l4jjb93l	58	4	influenza	influenza	NN
cord-334907-l4jjb93l	58	5	virus	virus	NN
cord-334907-l4jjb93l	58	6	C	C	NNP
cord-334907-l4jjb93l	58	7	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	58	8	-	-	HYPH
cord-334907-l4jjb93l	58	9	esterase	esterase	NN
cord-334907-l4jjb93l	58	10	-	-	HYPH
cord-334907-l4jjb93l	58	11	fusion	fusion	NN
cord-334907-l4jjb93l	58	12	HEF	HEF	NNP
cord-334907-l4jjb93l	58	13	,	,	,
cord-334907-l4jjb93l	58	14	a	a	DT
cord-334907-l4jjb93l	58	15	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	58	16	-	-	HYPH
cord-334907-l4jjb93l	58	17	like	like	JJ
cord-334907-l4jjb93l	58	18	domain	domain	NN
cord-334907-l4jjb93l	58	19	could	could	MD
cord-334907-l4jjb93l	58	20	constitute	constitute	VB
cord-334907-l4jjb93l	58	21	the	the	DT
cord-334907-l4jjb93l	58	22	amino	amino	NN
cord-334907-l4jjb93l	58	23	-	-	HYPH
cord-334907-l4jjb93l	58	24	terminal	terminal	NN
cord-334907-l4jjb93l	58	25	structure	structure	NN
cord-334907-l4jjb93l	58	26	of	of	IN
cord-334907-l4jjb93l	58	27	the	the	DT
cord-334907-l4jjb93l	58	28	protein	protein	NN
cord-334907-l4jjb93l	58	29	.	.	.
cord-334907-l4jjb93l	59	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	59	2	2020	2020	CD
cord-334907-l4jjb93l	59	3	,	,	,
cord-334907-l4jjb93l	59	4	9	9	CD
cord-334907-l4jjb93l	59	5	,	,	,
cord-334907-l4jjb93l	59	6	x	x	NN
cord-334907-l4jjb93l	59	7	FOR	for	IN
cord-334907-l4jjb93l	59	8	PEER	peer	NN
cord-334907-l4jjb93l	59	9	REVIEW	REVIEW	NNP
cord-334907-l4jjb93l	59	10	3	3	CD
cord-334907-l4jjb93l	59	11	of	of	IN
cord-334907-l4jjb93l	59	12	18	18	CD
cord-334907-l4jjb93l	59	13	interaction	interaction	NN
cord-334907-l4jjb93l	59	14	)	)	-RRB-
cord-334907-l4jjb93l	59	15	.	.	.
cord-334907-l4jjb93l	60	1	Finally	finally	RB
cord-334907-l4jjb93l	60	2	,	,	,
cord-334907-l4jjb93l	60	3	these	these	DT
cord-334907-l4jjb93l	60	4	results	result	NNS
cord-334907-l4jjb93l	60	5	offer	offer	VBP
cord-334907-l4jjb93l	60	6	new	new	JJ
cord-334907-l4jjb93l	60	7	insights	insight	NNS
cord-334907-l4jjb93l	60	8	into	into	IN
cord-334907-l4jjb93l	60	9	the	the	DT
cord-334907-l4jjb93l	60	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	60	11	fusion	fusion	NN
cord-334907-l4jjb93l	60	12	system	system	NN
cord-334907-l4jjb93l	60	13	,	,	,
cord-334907-l4jjb93l	60	14	and	and	CC
cord-334907-l4jjb93l	60	15	the	the	DT
cord-334907-l4jjb93l	60	16	directly	directly	RB
cord-334907-l4jjb93l	60	17	related	relate	VBN
cord-334907-l4jjb93l	60	18	infectivity	infectivity	NN
cord-334907-l4jjb93l	60	19	,	,	,
cord-334907-l4jjb93l	60	20	aiming	aim	VBG
cord-334907-l4jjb93l	60	21	to	to	TO
cord-334907-l4jjb93l	60	22	provide	provide	VB
cord-334907-l4jjb93l	60	23	a	a	DT
cord-334907-l4jjb93l	60	24	better	well	JJR
cord-334907-l4jjb93l	60	25	understanding	understanding	NN
cord-334907-l4jjb93l	60	26	of	of	IN
cord-334907-l4jjb93l	60	27	the	the	DT
cord-334907-l4jjb93l	60	28	viral	viral	JJ
cord-334907-l4jjb93l	60	29	behavior	behavior	NN
cord-334907-l4jjb93l	60	30	.	.	.
cord-334907-l4jjb93l	61	1	The	the	DT
cord-334907-l4jjb93l	61	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	61	3	F	F	NNP
cord-334907-l4jjb93l	61	4	carboxyl	carboxyl	NN
cord-334907-l4jjb93l	61	5	-	-	HYPH
cord-334907-l4jjb93l	61	6	end	end	NN
cord-334907-l4jjb93l	61	7	sequence	sequence	NN
cord-334907-l4jjb93l	61	8	contains	contain	VBZ
cord-334907-l4jjb93l	61	9	canonical	canonical	JJ
cord-334907-l4jjb93l	61	10	features	feature	NNS
cord-334907-l4jjb93l	61	11	of	of	IN
cord-334907-l4jjb93l	61	12	a	a	DT
cord-334907-l4jjb93l	61	13	type	type	NN
cord-334907-l4jjb93l	61	14	I	-PRON-	PRP
cord-334907-l4jjb93l	61	15	fusion	fusion	NN
cord-334907-l4jjb93l	61	16	protein	protein	NN
cord-334907-l4jjb93l	61	17	,	,	,
cord-334907-l4jjb93l	61	18	and	and	CC
cord-334907-l4jjb93l	61	19	its	-PRON-	PRP$
cord-334907-l4jjb93l	61	20	characteristics	characteristic	NNS
cord-334907-l4jjb93l	61	21	have	have	VBP
cord-334907-l4jjb93l	61	22	already	already	RB
cord-334907-l4jjb93l	61	23	been	be	VBN
cord-334907-l4jjb93l	61	24	thoroughly	thoroughly	RB
cord-334907-l4jjb93l	61	25	analyzed	analyze	VBN
cord-334907-l4jjb93l	61	26	[	[	-LRB-
cord-334907-l4jjb93l	61	27	12	12	CD
cord-334907-l4jjb93l	61	28	,	,	,
cord-334907-l4jjb93l	61	29	31	31	CD
cord-334907-l4jjb93l	61	30	]	]	-RRB-
cord-334907-l4jjb93l	61	31	.	.	.
cord-334907-l4jjb93l	62	1	Furthermore	furthermore	RB
cord-334907-l4jjb93l	62	2	,	,	,
cord-334907-l4jjb93l	62	3	the	the	DT
cord-334907-l4jjb93l	62	4	structure	structure	NN
cord-334907-l4jjb93l	62	5	of	of	IN
cord-334907-l4jjb93l	62	6	the	the	DT
cord-334907-l4jjb93l	62	7	fusion	fusion	NN
cord-334907-l4jjb93l	62	8	core	core	NN
cord-334907-l4jjb93l	62	9	has	have	VBZ
cord-334907-l4jjb93l	62	10	been	be	VBN
cord-334907-l4jjb93l	62	11	resolved	resolve	VBN
cord-334907-l4jjb93l	62	12	,	,	,
cord-334907-l4jjb93l	62	13	allowing	allow	VBG
cord-334907-l4jjb93l	62	14	for	for	IN
cord-334907-l4jjb93l	62	15	robust	robust	JJ
cord-334907-l4jjb93l	62	16	definition	definition	NN
cord-334907-l4jjb93l	62	17	of	of	IN
cord-334907-l4jjb93l	62	18	the	the	DT
cord-334907-l4jjb93l	62	19	two	two	CD
cord-334907-l4jjb93l	62	20	protein	protein	NN
cord-334907-l4jjb93l	62	21	domains	domain	NNS
cord-334907-l4jjb93l	62	22	:	:	:
cord-334907-l4jjb93l	62	23	a	a	DT
cord-334907-l4jjb93l	62	24	carboxyterminal	carboxyterminal	JJ
cord-334907-l4jjb93l	62	25	(	(	-LRB-
cord-334907-l4jjb93l	62	26	F2	F2	NNP
cord-334907-l4jjb93l	62	27	)	)	-RRB-
cord-334907-l4jjb93l	62	28	,	,	,
cord-334907-l4jjb93l	62	29	containing	contain	VBG
cord-334907-l4jjb93l	62	30	the	the	DT
cord-334907-l4jjb93l	62	31	transmembrane	transmembrane	NN
cord-334907-l4jjb93l	62	32	domain	domain	NN
cord-334907-l4jjb93l	62	33	,	,	,
cord-334907-l4jjb93l	62	34	a	a	DT
cord-334907-l4jjb93l	62	35	coiled	coiled	JJ
cord-334907-l4jjb93l	62	36	coil	coil	NN
cord-334907-l4jjb93l	62	37	region	region	NN
cord-334907-l4jjb93l	62	38	,	,	,
cord-334907-l4jjb93l	62	39	and	and	CC
cord-334907-l4jjb93l	62	40	a	a	DT
cord-334907-l4jjb93l	62	41	fusion	fusion	NN
cord-334907-l4jjb93l	62	42	peptide	peptide	NN
cord-334907-l4jjb93l	62	43	,	,	,
cord-334907-l4jjb93l	62	44	and	and	CC
cord-334907-l4jjb93l	62	45	an	an	DT
cord-334907-l4jjb93l	62	46	amino	amino	NN
cord-334907-l4jjb93l	62	47	-	-	HYPH
cord-334907-l4jjb93l	62	48	terminal	terminal	NN
cord-334907-l4jjb93l	62	49	domain	domain	NN
cord-334907-l4jjb93l	62	50	(	(	-LRB-
cord-334907-l4jjb93l	62	51	F1	F1	NNP
cord-334907-l4jjb93l	62	52	)	)	-RRB-
cord-334907-l4jjb93l	62	53	,	,	,
cord-334907-l4jjb93l	62	54	of	of	IN
cord-334907-l4jjb93l	62	55	undefined	undefined	JJ
cord-334907-l4jjb93l	62	56	tertiary	tertiary	JJ
cord-334907-l4jjb93l	62	57	structure	structure	NN
cord-334907-l4jjb93l	62	58	and	and	CC
cord-334907-l4jjb93l	62	59	function	function	NN
cord-334907-l4jjb93l	62	60	[	[	-LRB-
cord-334907-l4jjb93l	62	61	13	13	CD
cord-334907-l4jjb93l	62	62	]	]	-RRB-
cord-334907-l4jjb93l	62	63	.	.	.
cord-334907-l4jjb93l	63	1	Due	due	IN
cord-334907-l4jjb93l	63	2	to	to	IN
cord-334907-l4jjb93l	63	3	the	the	DT
cord-334907-l4jjb93l	63	4	lack	lack	NN
cord-334907-l4jjb93l	63	5	of	of	IN
cord-334907-l4jjb93l	63	6	a	a	DT
cord-334907-l4jjb93l	63	7	crystal	crystal	NN
cord-334907-l4jjb93l	63	8	structure	structure	NN
cord-334907-l4jjb93l	63	9	and	and	CC
cord-334907-l4jjb93l	63	10	robust	robust	JJ
cord-334907-l4jjb93l	63	11	sequence	sequence	NN
cord-334907-l4jjb93l	63	12	homology	homology	NN
cord-334907-l4jjb93l	63	13	to	to	IN
cord-334907-l4jjb93l	63	14	proteins	protein	NNS
cord-334907-l4jjb93l	63	15	from	from	IN
cord-334907-l4jjb93l	63	16	other	other	JJ
cord-334907-l4jjb93l	63	17	species	specie	NNS
cord-334907-l4jjb93l	63	18	for	for	IN
cord-334907-l4jjb93l	63	19	the	the	DT
cord-334907-l4jjb93l	63	20	amino	amino	NN
cord-334907-l4jjb93l	63	21	-	-	HYPH
cord-334907-l4jjb93l	63	22	terminal	terminal	NN
cord-334907-l4jjb93l	63	23	domain	domain	NN
cord-334907-l4jjb93l	63	24	of	of	IN
cord-334907-l4jjb93l	63	25	F	F	NNP
cord-334907-l4jjb93l	63	26	,	,	,
cord-334907-l4jjb93l	63	27	we	-PRON-	PRP
cord-334907-l4jjb93l	63	28	aimed	aim	VBD
cord-334907-l4jjb93l	63	29	to	to	TO
cord-334907-l4jjb93l	63	30	develop	develop	VB
cord-334907-l4jjb93l	63	31	a	a	DT
cord-334907-l4jjb93l	63	32	structural	structural	JJ
cord-334907-l4jjb93l	63	33	model	model	NN
cord-334907-l4jjb93l	63	34	for	for	IN
cord-334907-l4jjb93l	63	35	this	this	DT
cord-334907-l4jjb93l	63	36	subdomain	subdomain	NN
cord-334907-l4jjb93l	63	37	.	.	.
cord-334907-l4jjb93l	64	1	A	a	DT
cord-334907-l4jjb93l	64	2	secondary	secondary	JJ
cord-334907-l4jjb93l	64	3	structure	structure	NN
cord-334907-l4jjb93l	64	4	analysis	analysis	NN
cord-334907-l4jjb93l	64	5	of	of	IN
cord-334907-l4jjb93l	64	6	the	the	DT
cord-334907-l4jjb93l	64	7	amino	amino	NN
cord-334907-l4jjb93l	64	8	acid	acid	NN
cord-334907-l4jjb93l	64	9	sequence	sequence	NN
cord-334907-l4jjb93l	64	10	for	for	IN
cord-334907-l4jjb93l	64	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	64	12	F	F	NNP
cord-334907-l4jjb93l	64	13	revealed	reveal	VBD
cord-334907-l4jjb93l	64	14	a	a	DT
cord-334907-l4jjb93l	64	15	high	high	JJ
cord-334907-l4jjb93l	64	16	content	content	NN
cord-334907-l4jjb93l	64	17	of	of	IN
cord-334907-l4jjb93l	64	18	beta	beta	JJ
cord-334907-l4jjb93l	64	19	strands	strand	NNS
cord-334907-l4jjb93l	64	20	for	for	IN
cord-334907-l4jjb93l	64	21	the	the	DT
cord-334907-l4jjb93l	64	22	F1	F1	NNP
cord-334907-l4jjb93l	64	23	subunit	subunit	NN
cord-334907-l4jjb93l	64	24	,	,	,
cord-334907-l4jjb93l	64	25	with	with	IN
cord-334907-l4jjb93l	64	26	this	this	DT
cord-334907-l4jjb93l	64	27	topology	topology	NN
cord-334907-l4jjb93l	64	28	being	be	VBG
cord-334907-l4jjb93l	64	29	characteristic	characteristic	JJ
cord-334907-l4jjb93l	64	30	of	of	IN
cord-334907-l4jjb93l	64	31	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	64	32	domains	domain	NNS
cord-334907-l4jjb93l	64	33	[	[	-LRB-
cord-334907-l4jjb93l	64	34	32	32	CD
cord-334907-l4jjb93l	64	35	]	]	-RRB-
cord-334907-l4jjb93l	64	36	(	(	-LRB-
cord-334907-l4jjb93l	64	37	Figure	figure	NN
cord-334907-l4jjb93l	64	38	1	1	CD
cord-334907-l4jjb93l	64	39	)	)	-RRB-
cord-334907-l4jjb93l	64	40	.	.	.
cord-334907-l4jjb93l	65	1	Considering	consider	VBG
cord-334907-l4jjb93l	65	2	that	that	IN
cord-334907-l4jjb93l	65	3	the	the	DT
cord-334907-l4jjb93l	65	4	F2	F2	NNP
cord-334907-l4jjb93l	65	5	domain	domain	NN
cord-334907-l4jjb93l	65	6	resembles	resemble	VBZ
cord-334907-l4jjb93l	65	7	the	the	DT
cord-334907-l4jjb93l	65	8	carboxy	carboxy	JJ
cord-334907-l4jjb93l	65	9	-	-	HYPH
cord-334907-l4jjb93l	65	10	terminal	terminal	NN
cord-334907-l4jjb93l	65	11	domain	domain	NN
cord-334907-l4jjb93l	65	12	of	of	IN
cord-334907-l4jjb93l	65	13	influenza	influenza	NN
cord-334907-l4jjb93l	65	14	virus	virus	NN
cord-334907-l4jjb93l	66	1	A	a	DT
cord-334907-l4jjb93l	66	2	HA	HA	NNP
cord-334907-l4jjb93l	66	3	and	and	CC
cord-334907-l4jjb93l	66	4	influenza	influenza	NN
cord-334907-l4jjb93l	66	5	virus	virus	NN
cord-334907-l4jjb93l	66	6	C	C	NNP
cord-334907-l4jjb93l	66	7	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	66	8	-	-	HYPH
cord-334907-l4jjb93l	66	9	esterase	esterase	NN
cord-334907-l4jjb93l	66	10	-	-	HYPH
cord-334907-l4jjb93l	66	11	fusion	fusion	NN
cord-334907-l4jjb93l	66	12	HEF	HEF	NNP
cord-334907-l4jjb93l	66	13	,	,	,
cord-334907-l4jjb93l	66	14	a	a	DT
cord-334907-l4jjb93l	66	15	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	66	16	-	-	HYPH
cord-334907-l4jjb93l	66	17	like	like	JJ
cord-334907-l4jjb93l	66	18	domain	domain	NN
cord-334907-l4jjb93l	66	19	could	could	MD
cord-334907-l4jjb93l	66	20	constitute	constitute	VB
cord-334907-l4jjb93l	66	21	the	the	DT
cord-334907-l4jjb93l	66	22	amino	amino	NN
cord-334907-l4jjb93l	66	23	-	-	HYPH
cord-334907-l4jjb93l	66	24	terminal	terminal	NN
cord-334907-l4jjb93l	66	25	structure	structure	NN
cord-334907-l4jjb93l	66	26	of	of	IN
cord-334907-l4jjb93l	66	27	the	the	DT
cord-334907-l4jjb93l	66	28	protein	protein	NN
cord-334907-l4jjb93l	66	29	.	.	.
cord-334907-l4jjb93l	67	1	Conservation	conservation	NN
cord-334907-l4jjb93l	67	2	of	of	IN
cord-334907-l4jjb93l	67	3	secondary	secondary	JJ
cord-334907-l4jjb93l	67	4	structure	structure	NN
cord-334907-l4jjb93l	67	5	among	among	IN
cord-334907-l4jjb93l	67	6	viral	viral	JJ
cord-334907-l4jjb93l	67	7	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	67	8	.	.	.
cord-334907-l4jjb93l	68	1	(	(	-LRB-
cord-334907-l4jjb93l	68	2	a	a	LS
cord-334907-l4jjb93l	68	3	)	)	-RRB-
cord-334907-l4jjb93l	68	4	Secondary	secondary	JJ
cord-334907-l4jjb93l	68	5	structure	structure	NN
cord-334907-l4jjb93l	68	6	comparison	comparison	NN
cord-334907-l4jjb93l	68	7	for	for	IN
cord-334907-l4jjb93l	68	8	diverse	diverse	JJ
cord-334907-l4jjb93l	68	9	viral	viral	JJ
cord-334907-l4jjb93l	68	10	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	68	11	.	.	.
cord-334907-l4jjb93l	69	1	PSIPRED	PSIPRED	NNP
cord-334907-l4jjb93l	69	2	was	be	VBD
cord-334907-l4jjb93l	69	3	used	use	VBN
cord-334907-l4jjb93l	69	4	to	to	TO
cord-334907-l4jjb93l	69	5	calculate	calculate	VB
cord-334907-l4jjb93l	69	6	a	a	DT
cord-334907-l4jjb93l	69	7	secondary	secondary	JJ
cord-334907-l4jjb93l	69	8	structure	structure	NN
cord-334907-l4jjb93l	69	9	for	for	IN
cord-334907-l4jjb93l	69	10	infectious	infectious	JJ
cord-334907-l4jjb93l	69	11	salmon	salmon	NN
cord-334907-l4jjb93l	69	12	anemia	anemia	NN
cord-334907-l4jjb93l	69	13	virus	virus	NN
cord-334907-l4jjb93l	69	14	(	(	-LRB-
cord-334907-l4jjb93l	69	15	ISAV	ISAV	NNP
cord-334907-l4jjb93l	69	16	)	)	-RRB-
cord-334907-l4jjb93l	69	17	fusion	fusion	NN
cord-334907-l4jjb93l	69	18	protein	protein	NN
cord-334907-l4jjb93l	69	19	(	(	-LRB-
cord-334907-l4jjb93l	69	20	F	F	NNP
cord-334907-l4jjb93l	69	21	)	)	-RRB-
cord-334907-l4jjb93l	69	22	(	(	-LRB-
cord-334907-l4jjb93l	69	23	AAX46273.1	aax46273.1	RB
cord-334907-l4jjb93l	69	24	)	)	-RRB-
cord-334907-l4jjb93l	69	25	,	,	,
cord-334907-l4jjb93l	69	26	and	and	CC
cord-334907-l4jjb93l	69	27	experimentally	experimentally	RB
cord-334907-l4jjb93l	69	28	defined	define	VBN
cord-334907-l4jjb93l	69	29	secondary	secondary	JJ
cord-334907-l4jjb93l	69	30	structures	structure	NNS
cord-334907-l4jjb93l	69	31	for	for	IN
cord-334907-l4jjb93l	69	32	influenza	influenza	NN
cord-334907-l4jjb93l	69	33	virus	virus	NN
cord-334907-l4jjb93l	69	34	A	a	DT
cord-334907-l4jjb93l	69	35	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	69	36	(	(	-LRB-
cord-334907-l4jjb93l	69	37	HA	HA	NNP
cord-334907-l4jjb93l	69	38	)	)	-RRB-
cord-334907-l4jjb93l	70	1	(	(	-LRB-
cord-334907-l4jjb93l	70	2	Inf	Inf	NNP
cord-334907-l4jjb93l	70	3	HA	HA	NNP
cord-334907-l4jjb93l	70	4	)	)	-RRB-
cord-334907-l4jjb93l	70	5	,	,	,
cord-334907-l4jjb93l	70	6	influenza	influenza	NN
cord-334907-l4jjb93l	70	7	virus	virus	NN
cord-334907-l4jjb93l	70	8	C	c	NN
cord-334907-l4jjb93l	70	9	HEF	HEF	NNP
cord-334907-l4jjb93l	70	10	(	(	-LRB-
cord-334907-l4jjb93l	70	11	Inf	Inf	NNP
cord-334907-l4jjb93l	70	12	HEF	HEF	NNP
cord-334907-l4jjb93l	70	13	)	)	-RRB-
cord-334907-l4jjb93l	70	14	,	,	.
cord-334907-l4jjb93l	71	1	porcine	porcine	JJ
cord-334907-l4jjb93l	71	2	torovirus	torovirus	NNP
cord-334907-l4jjb93l	71	3	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	71	4	esterase	esterase	NN
cord-334907-l4jjb93l	71	5	(	(	-LRB-
cord-334907-l4jjb93l	71	6	PToV	PToV	NNP
cord-334907-l4jjb93l	71	7	HE	HE	NNP
cord-334907-l4jjb93l	71	8	)	)	-RRB-
cord-334907-l4jjb93l	71	9	,	,	,
cord-334907-l4jjb93l	71	10	and	and	CC
cord-334907-l4jjb93l	71	11	bovine	bovine	JJ
cord-334907-l4jjb93l	71	12	coronavirus	coronavirus	NN
cord-334907-l4jjb93l	71	13	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	71	14	esterase	esterase	NN
cord-334907-l4jjb93l	71	15	(	(	-LRB-
cord-334907-l4jjb93l	71	16	BCoV	BCoV	NNP
cord-334907-l4jjb93l	71	17	HE	HE	NNP
cord-334907-l4jjb93l	71	18	)	)	-RRB-
cord-334907-l4jjb93l	71	19	were	be	VBD
cord-334907-l4jjb93l	71	20	obtained	obtain	VBN
cord-334907-l4jjb93l	71	21	from	from	IN
cord-334907-l4jjb93l	71	22	their	-PRON-	PRP$
cord-334907-l4jjb93l	71	23	PDB	PDB	NNP
cord-334907-l4jjb93l	71	24	entries	entry	NNS
cord-334907-l4jjb93l	71	25	(	(	-LRB-
cord-334907-l4jjb93l	71	26	5XRS	5xrs	UH
cord-334907-l4jjb93l	71	27	,	,	,
cord-334907-l4jjb93l	71	28	1FLC	1flc	CD
cord-334907-l4jjb93l	71	29	,	,	,
cord-334907-l4jjb93l	71	30	3ILK	3ilk	CD
cord-334907-l4jjb93l	71	31	,	,	,
cord-334907-l4jjb93l	71	32	and	and	CC
cord-334907-l4jjb93l	71	33	3CL5	3cl5	CD
cord-334907-l4jjb93l	71	34	,	,	,
cord-334907-l4jjb93l	71	35	respectively	respectively	RB
cord-334907-l4jjb93l	71	36	)	)	-RRB-
cord-334907-l4jjb93l	71	37	.	.	.
cord-334907-l4jjb93l	72	1	Beta	beta	JJ
cord-334907-l4jjb93l	72	2	strands	strand	NNS
cord-334907-l4jjb93l	72	3	and	and	CC
cord-334907-l4jjb93l	72	4	alpha	alpha	NN
cord-334907-l4jjb93l	72	5	helices	helix	NNS
cord-334907-l4jjb93l	72	6	are	be	VBP
cord-334907-l4jjb93l	72	7	indicated	indicate	VBN
cord-334907-l4jjb93l	72	8	by	by	IN
cord-334907-l4jjb93l	72	9	red	red	JJ
cord-334907-l4jjb93l	72	10	and	and	CC
cord-334907-l4jjb93l	72	11	blue	blue	JJ
cord-334907-l4jjb93l	72	12	arrows	arrow	NNS
cord-334907-l4jjb93l	72	13	,	,	,
cord-334907-l4jjb93l	72	14	respectively	respectively	RB
cord-334907-l4jjb93l	72	15	.	.	.
cord-334907-l4jjb93l	73	1	Boxed	box	VBN
cord-334907-l4jjb93l	73	2	in	in	IN
cord-334907-l4jjb93l	73	3	green	green	JJ
cord-334907-l4jjb93l	73	4	are	be	VBP
cord-334907-l4jjb93l	73	5	the	the	DT
cord-334907-l4jjb93l	73	6	receptor	receptor	NN
cord-334907-l4jjb93l	73	7	-	-	HYPH
cord-334907-l4jjb93l	73	8	binding	bind	VBG
cord-334907-l4jjb93l	73	9	domains	domain	NNS
cord-334907-l4jjb93l	73	10	of	of	IN
cord-334907-l4jjb93l	73	11	each	each	DT
cord-334907-l4jjb93l	73	12	protein	protein	NN
cord-334907-l4jjb93l	73	13	.	.	.
cord-334907-l4jjb93l	74	1	There	there	EX
cord-334907-l4jjb93l	74	2	is	be	VBZ
cord-334907-l4jjb93l	74	3	a	a	DT
cord-334907-l4jjb93l	74	4	clear	clear	JJ
cord-334907-l4jjb93l	74	5	conservation	conservation	NN
cord-334907-l4jjb93l	74	6	of	of	IN
cord-334907-l4jjb93l	74	7	beta	beta	NN
cord-334907-l4jjb93l	74	8	strands	strand	NNS
cord-334907-l4jjb93l	74	9	in	in	IN
cord-334907-l4jjb93l	74	10	all	all	DT
cord-334907-l4jjb93l	74	11	of	of	IN
cord-334907-l4jjb93l	74	12	the	the	DT
cord-334907-l4jjb93l	74	13	receptor	receptor	NN
cord-334907-l4jjb93l	74	14	-	-	HYPH
cord-334907-l4jjb93l	74	15	binding	bind	VBG
cord-334907-l4jjb93l	74	16	domains	domain	NNS
cord-334907-l4jjb93l	74	17	(	(	-LRB-
cord-334907-l4jjb93l	74	18	b	b	NN
cord-334907-l4jjb93l	74	19	)	)	-RRB-
cord-334907-l4jjb93l	74	20	Tertiary	tertiary	JJ
cord-334907-l4jjb93l	74	21	structure	structure	NN
cord-334907-l4jjb93l	74	22	of	of	IN
cord-334907-l4jjb93l	74	23	the	the	DT
cord-334907-l4jjb93l	74	24	receptor	receptor	NN
cord-334907-l4jjb93l	74	25	-	-	HYPH
cord-334907-l4jjb93l	74	26	binding	bind	VBG
cord-334907-l4jjb93l	74	27	domain	domain	NN
cord-334907-l4jjb93l	74	28	for	for	IN
cord-334907-l4jjb93l	74	29	the	the	DT
cord-334907-l4jjb93l	74	30	selected	select	VBN
cord-334907-l4jjb93l	74	31	viral	viral	JJ
cord-334907-l4jjb93l	74	32	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	74	33	.	.	.
cord-334907-l4jjb93l	75	1	Beta	beta	JJ
cord-334907-l4jjb93l	75	2	strands	strand	NNS
cord-334907-l4jjb93l	75	3	constitute	constitute	VBP
cord-334907-l4jjb93l	75	4	a	a	DT
cord-334907-l4jjb93l	75	5	Swiss	swiss	JJ
cord-334907-l4jjb93l	75	6	roll	roll	NN
cord-334907-l4jjb93l	75	7	domain	domain	NN
cord-334907-l4jjb93l	75	8	,	,	,
cord-334907-l4jjb93l	75	9	with	with	IN
cord-334907-l4jjb93l	75	10	interstrand	interstrand	NNP
cord-334907-l4jjb93l	75	11	loops	loop	NNS
cord-334907-l4jjb93l	75	12	defining	define	VBG
cord-334907-l4jjb93l	75	13	the	the	DT
cord-334907-l4jjb93l	75	14	specificity	specificity	NN
cord-334907-l4jjb93l	75	15	of	of	IN
cord-334907-l4jjb93l	75	16	interaction	interaction	NN
cord-334907-l4jjb93l	75	17	in	in	IN
cord-334907-l4jjb93l	75	18	each	each	DT
cord-334907-l4jjb93l	75	19	molecule	molecule	NN
cord-334907-l4jjb93l	75	20	.	.	.
cord-334907-l4jjb93l	76	1	The	the	DT
cord-334907-l4jjb93l	76	2	corresponding	corresponding	JJ
cord-334907-l4jjb93l	76	3	cellular	cellular	JJ
cord-334907-l4jjb93l	76	4	receptor	receptor	NN
cord-334907-l4jjb93l	76	5	is	be	VBZ
cord-334907-l4jjb93l	76	6	shown	show	VBN
cord-334907-l4jjb93l	76	7	.	.	.
cord-334907-l4jjb93l	77	1	A	a	DT
cord-334907-l4jjb93l	77	2	putative	putative	JJ
cord-334907-l4jjb93l	77	3	ligand	ligand	NN
cord-334907-l4jjb93l	77	4	-	-	HYPH
cord-334907-l4jjb93l	77	5	binding	bind	VBG
cord-334907-l4jjb93l	77	6	subdomain	subdomain	NN
cord-334907-l4jjb93l	77	7	(	(	-LRB-
cord-334907-l4jjb93l	77	8	F1LB	F1LB	NNP
cord-334907-l4jjb93l	77	9	)	)	-RRB-
cord-334907-l4jjb93l	77	10	was	be	VBD
cord-334907-l4jjb93l	77	11	defined	define	VBN
cord-334907-l4jjb93l	77	12	between	between	IN
cord-334907-l4jjb93l	77	13	positions	position	NNS
cord-334907-l4jjb93l	77	14	100	100	CD
cord-334907-l4jjb93l	77	15	to	to	TO
cord-334907-l4jjb93l	77	16	239	239	CD
cord-334907-l4jjb93l	77	17	of	of	IN
cord-334907-l4jjb93l	77	18	the	the	DT
cord-334907-l4jjb93l	77	19	AAX46273.1	AAX46273.1	NNP
cord-334907-l4jjb93l	77	20	sequence	sequence	NN
cord-334907-l4jjb93l	77	21	,	,	,
cord-334907-l4jjb93l	77	22	considering	consider	VBG
cord-334907-l4jjb93l	77	23	the	the	DT
cord-334907-l4jjb93l	77	24	presence	presence	NN
cord-334907-l4jjb93l	77	25	of	of	IN
cord-334907-l4jjb93l	77	26	theoretical	theoretical	JJ
cord-334907-l4jjb93l	77	27	alpha	alpha	NN
cord-334907-l4jjb93l	77	28	helices	helix	NNS
cord-334907-l4jjb93l	77	29	between	between	IN
cord-334907-l4jjb93l	77	30	residues	residue	NNS
cord-334907-l4jjb93l	77	31	84	84	CD
cord-334907-l4jjb93l	77	32	-	-	SYM
cord-334907-l4jjb93l	77	33	91	91	CD
cord-334907-l4jjb93l	77	34	and	and	CC
cord-334907-l4jjb93l	77	35	249	249	CD
cord-334907-l4jjb93l	77	36	-	-	SYM
cord-334907-l4jjb93l	77	37	254	254	CD
cord-334907-l4jjb93l	77	38	in	in	IN
cord-334907-l4jjb93l	77	39	F1	F1	NNP
cord-334907-l4jjb93l	77	40	,	,	,
cord-334907-l4jjb93l	77	41	typical	typical	JJ
cord-334907-l4jjb93l	77	42	of	of	IN
cord-334907-l4jjb93l	77	43	the	the	DT
cord-334907-l4jjb93l	77	44	carboxyl	carboxyl	NN
cord-334907-l4jjb93l	77	45	and	and	CC
cord-334907-l4jjb93l	77	46	amino	amino	NN
cord-334907-l4jjb93l	77	47	ends	end	NNS
cord-334907-l4jjb93l	77	48	of	of	IN
cord-334907-l4jjb93l	77	49	the	the	DT
cord-334907-l4jjb93l	77	50	receptor	receptor	NN
cord-334907-l4jjb93l	77	51	-	-	HYPH
cord-334907-l4jjb93l	77	52	binding	bind	VBG
cord-334907-l4jjb93l	77	53	domain	domain	NN
cord-334907-l4jjb93l	77	54	of	of	IN
cord-334907-l4jjb93l	77	55	viral	viral	JJ
cord-334907-l4jjb93l	77	56	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	77	57	.	.	.
cord-334907-l4jjb93l	78	1	A	a	DT
cord-334907-l4jjb93l	78	2	theoretical	theoretical	JJ
cord-334907-l4jjb93l	78	3	3D	3d	JJ
cord-334907-l4jjb93l	78	4	model	model	NN
cord-334907-l4jjb93l	78	5	for	for	IN
cord-334907-l4jjb93l	78	6	F1LB	F1LB	NNP
cord-334907-l4jjb93l	78	7	was	be	VBD
cord-334907-l4jjb93l	78	8	obtained	obtain	VBN
cord-334907-l4jjb93l	78	9	using	use	VBG
cord-334907-l4jjb93l	78	10	comparative	comparative	JJ
cord-334907-l4jjb93l	78	11	modeling	modeling	NN
cord-334907-l4jjb93l	78	12	using	use	VBG
cord-334907-l4jjb93l	78	13	the	the	DT
cord-334907-l4jjb93l	78	14	PToV	PToV	NNP
cord-334907-l4jjb93l	78	15	HE	HE	NNP
cord-334907-l4jjb93l	78	16	as	as	IN
cord-334907-l4jjb93l	78	17	a	a	DT
cord-334907-l4jjb93l	78	18	template	template	NN
cord-334907-l4jjb93l	78	19	,	,	,
cord-334907-l4jjb93l	78	20	with	with	IN
cord-334907-l4jjb93l	78	21	a	a	DT
cord-334907-l4jjb93l	78	22	manual	manual	JJ
cord-334907-l4jjb93l	78	23	alignment	alignment	NN
cord-334907-l4jjb93l	78	24	based	base	VBN
cord-334907-l4jjb93l	78	25	on	on	IN
cord-334907-l4jjb93l	78	26	the	the	DT
cord-334907-l4jjb93l	78	27	secondary	secondary	JJ
cord-334907-l4jjb93l	78	28	structure	structure	NN
cord-334907-l4jjb93l	78	29	of	of	IN
cord-334907-l4jjb93l	78	30	each	each	DT
cord-334907-l4jjb93l	78	31	sequence	sequence	NN
cord-334907-l4jjb93l	78	32	(	(	-LRB-
cord-334907-l4jjb93l	78	33	Figure	figure	NN
cord-334907-l4jjb93l	78	34	 	 	_SP
cord-334907-l4jjb93l	78	35	2	2	CD
cord-334907-l4jjb93l	78	36	)	)	-RRB-
cord-334907-l4jjb93l	78	37	.	.	.
cord-334907-l4jjb93l	79	1	The	the	DT
cord-334907-l4jjb93l	79	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	79	3	F1	f1	NN
cord-334907-l4jjb93l	79	4	beta	beta	NN
cord-334907-l4jjb93l	79	5	strands	strand	NNS
cord-334907-l4jjb93l	79	6	are	be	VBP
cord-334907-l4jjb93l	79	7	arranged	arrange	VBN
cord-334907-l4jjb93l	79	8	in	in	IN
cord-334907-l4jjb93l	79	9	an	an	DT
cord-334907-l4jjb93l	79	10	antiparallel	antiparallel	JJ
cord-334907-l4jjb93l	79	11	fashion	fashion	NN
cord-334907-l4jjb93l	79	12	,	,	,
cord-334907-l4jjb93l	79	13	forming	form	VBG
cord-334907-l4jjb93l	79	14	a	a	DT
cord-334907-l4jjb93l	79	15	Swiss	swiss	JJ
cord-334907-l4jjb93l	79	16	roll	roll	NN
cord-334907-l4jjb93l	79	17	structure	structure	NN
cord-334907-l4jjb93l	79	18	,	,	,
cord-334907-l4jjb93l	79	19	A	a	DT
cord-334907-l4jjb93l	79	20	putative	putative	JJ
cord-334907-l4jjb93l	79	21	ligand	ligand	NN
cord-334907-l4jjb93l	79	22	-	-	HYPH
cord-334907-l4jjb93l	79	23	binding	bind	VBG
cord-334907-l4jjb93l	79	24	subdomain	subdomain	NN
cord-334907-l4jjb93l	79	25	(	(	-LRB-
cord-334907-l4jjb93l	79	26	F	F	NNP
cord-334907-l4jjb93l	79	27	1	1	CD
cord-334907-l4jjb93l	79	28	LB	LB	NNP
cord-334907-l4jjb93l	79	29	)	)	-RRB-
cord-334907-l4jjb93l	79	30	was	be	VBD
cord-334907-l4jjb93l	79	31	defined	define	VBN
cord-334907-l4jjb93l	79	32	between	between	IN
cord-334907-l4jjb93l	79	33	positions	position	NNS
cord-334907-l4jjb93l	79	34	100	100	CD
cord-334907-l4jjb93l	79	35	to	to	TO
cord-334907-l4jjb93l	79	36	239	239	CD
cord-334907-l4jjb93l	79	37	of	of	IN
cord-334907-l4jjb93l	79	38	the	the	DT
cord-334907-l4jjb93l	79	39	AAX46273.1	AAX46273.1	NNP
cord-334907-l4jjb93l	79	40	sequence	sequence	NN
cord-334907-l4jjb93l	79	41	,	,	,
cord-334907-l4jjb93l	79	42	considering	consider	VBG
cord-334907-l4jjb93l	79	43	the	the	DT
cord-334907-l4jjb93l	79	44	presence	presence	NN
cord-334907-l4jjb93l	79	45	of	of	IN
cord-334907-l4jjb93l	79	46	theoretical	theoretical	JJ
cord-334907-l4jjb93l	79	47	alpha	alpha	NN
cord-334907-l4jjb93l	79	48	helices	helix	NNS
cord-334907-l4jjb93l	79	49	between	between	IN
cord-334907-l4jjb93l	79	50	residues	residue	NNS
cord-334907-l4jjb93l	79	51	84	84	CD
cord-334907-l4jjb93l	79	52	-	-	SYM
cord-334907-l4jjb93l	79	53	91	91	CD
cord-334907-l4jjb93l	79	54	and	and	CC
cord-334907-l4jjb93l	79	55	249	249	CD
cord-334907-l4jjb93l	79	56	-	-	SYM
cord-334907-l4jjb93l	79	57	254	254	CD
cord-334907-l4jjb93l	79	58	in	in	IN
cord-334907-l4jjb93l	79	59	F	F	NNP
cord-334907-l4jjb93l	79	60	1	1	CD
cord-334907-l4jjb93l	79	61	,	,	,
cord-334907-l4jjb93l	79	62	typical	typical	JJ
cord-334907-l4jjb93l	79	63	of	of	IN
cord-334907-l4jjb93l	79	64	the	the	DT
cord-334907-l4jjb93l	79	65	carboxyl	carboxyl	NN
cord-334907-l4jjb93l	79	66	and	and	CC
cord-334907-l4jjb93l	79	67	amino	amino	NN
cord-334907-l4jjb93l	79	68	ends	end	NNS
cord-334907-l4jjb93l	79	69	of	of	IN
cord-334907-l4jjb93l	79	70	the	the	DT
cord-334907-l4jjb93l	79	71	receptor	receptor	NN
cord-334907-l4jjb93l	79	72	-	-	HYPH
cord-334907-l4jjb93l	79	73	binding	bind	VBG
cord-334907-l4jjb93l	79	74	domain	domain	NN
cord-334907-l4jjb93l	79	75	of	of	IN
cord-334907-l4jjb93l	79	76	viral	viral	JJ
cord-334907-l4jjb93l	79	77	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	79	78	.	.	.
cord-334907-l4jjb93l	80	1	A	a	DT
cord-334907-l4jjb93l	80	2	theoretical	theoretical	JJ
cord-334907-l4jjb93l	80	3	3D	3d	JJ
cord-334907-l4jjb93l	80	4	model	model	NN
cord-334907-l4jjb93l	80	5	for	for	IN
cord-334907-l4jjb93l	80	6	F	F	NNP
cord-334907-l4jjb93l	80	7	1	1	CD
cord-334907-l4jjb93l	80	8	LB	LB	NNP
cord-334907-l4jjb93l	80	9	was	be	VBD
cord-334907-l4jjb93l	80	10	obtained	obtain	VBN
cord-334907-l4jjb93l	80	11	using	use	VBG
cord-334907-l4jjb93l	80	12	comparative	comparative	JJ
cord-334907-l4jjb93l	80	13	modeling	modeling	NN
cord-334907-l4jjb93l	80	14	using	use	VBG
cord-334907-l4jjb93l	80	15	the	the	DT
cord-334907-l4jjb93l	80	16	PToV	PToV	NNP
cord-334907-l4jjb93l	80	17	HE	HE	NNP
cord-334907-l4jjb93l	80	18	as	as	IN
cord-334907-l4jjb93l	80	19	a	a	DT
cord-334907-l4jjb93l	80	20	template	template	NN
cord-334907-l4jjb93l	80	21	,	,	,
cord-334907-l4jjb93l	80	22	with	with	IN
cord-334907-l4jjb93l	80	23	a	a	DT
cord-334907-l4jjb93l	80	24	manual	manual	JJ
cord-334907-l4jjb93l	80	25	alignment	alignment	NN
cord-334907-l4jjb93l	80	26	based	base	VBN
cord-334907-l4jjb93l	80	27	on	on	IN
cord-334907-l4jjb93l	80	28	the	the	DT
cord-334907-l4jjb93l	80	29	secondary	secondary	JJ
cord-334907-l4jjb93l	80	30	structure	structure	NN
cord-334907-l4jjb93l	80	31	of	of	IN
cord-334907-l4jjb93l	80	32	each	each	DT
cord-334907-l4jjb93l	80	33	sequence	sequence	NN
cord-334907-l4jjb93l	81	1	(	(	-LRB-
cord-334907-l4jjb93l	81	2	Figure	figure	NN
cord-334907-l4jjb93l	81	3	2	2	CD
cord-334907-l4jjb93l	81	4	)	)	-RRB-
cord-334907-l4jjb93l	81	5	.	.	.
cord-334907-l4jjb93l	82	1	The	the	DT
cord-334907-l4jjb93l	82	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	82	3	F	F	NNP
cord-334907-l4jjb93l	82	4	1	1	CD
cord-334907-l4jjb93l	82	5	beta	beta	NN
cord-334907-l4jjb93l	82	6	strands	strand	NNS
cord-334907-l4jjb93l	82	7	are	be	VBP
cord-334907-l4jjb93l	82	8	arranged	arrange	VBN
cord-334907-l4jjb93l	82	9	in	in	IN
cord-334907-l4jjb93l	82	10	an	an	DT
cord-334907-l4jjb93l	82	11	antiparallel	antiparallel	JJ
cord-334907-l4jjb93l	82	12	fashion	fashion	NN
cord-334907-l4jjb93l	82	13	,	,	,
cord-334907-l4jjb93l	82	14	forming	form	VBG
cord-334907-l4jjb93l	82	15	a	a	DT
cord-334907-l4jjb93l	82	16	Swiss	swiss	JJ
cord-334907-l4jjb93l	82	17	roll	roll	NN
cord-334907-l4jjb93l	82	18	structure	structure	NN
cord-334907-l4jjb93l	82	19	,	,	,
cord-334907-l4jjb93l	82	20	similar	similar	JJ
cord-334907-l4jjb93l	82	21	to	to	IN
cord-334907-l4jjb93l	82	22	viral	viral	JJ
cord-334907-l4jjb93l	82	23	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	82	24	.	.	.
cord-334907-l4jjb93l	83	1	In	in	IN
cord-334907-l4jjb93l	83	2	canonical	canonical	JJ
cord-334907-l4jjb93l	83	3	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	83	4	,	,	,
cord-334907-l4jjb93l	83	5	residues	residue	NNS
cord-334907-l4jjb93l	83	6	located	locate	VBN
cord-334907-l4jjb93l	83	7	at	at	IN
cord-334907-l4jjb93l	83	8	the	the	DT
cord-334907-l4jjb93l	83	9	loops	loop	NNS
cord-334907-l4jjb93l	83	10	connecting	connect	VBG
cord-334907-l4jjb93l	83	11	the	the	DT
cord-334907-l4jjb93l	83	12	beta	beta	NN
cord-334907-l4jjb93l	83	13	strands	strand	NNS
cord-334907-l4jjb93l	83	14	are	be	VBP
cord-334907-l4jjb93l	83	15	involved	involve	VBN
cord-334907-l4jjb93l	83	16	in	in	IN
cord-334907-l4jjb93l	83	17	ligand	ligand	NN
cord-334907-l4jjb93l	83	18	binding	binding	NN
cord-334907-l4jjb93l	83	19	,	,	,
cord-334907-l4jjb93l	83	20	with	with	IN
cord-334907-l4jjb93l	83	21	a	a	DT
cord-334907-l4jjb93l	83	22	hydrophobic	hydrophobic	JJ
cord-334907-l4jjb93l	83	23	pocket	pocket	NN
cord-334907-l4jjb93l	83	24	commonly	commonly	RB
cord-334907-l4jjb93l	83	25	interacting	interact	VBG
cord-334907-l4jjb93l	83	26	with	with	IN
cord-334907-l4jjb93l	83	27	the	the	DT
cord-334907-l4jjb93l	83	28	glycan	glycan	NN
cord-334907-l4jjb93l	83	29	[	[	-LRB-
cord-334907-l4jjb93l	83	30	33	33	CD
cord-334907-l4jjb93l	83	31	]	]	-RRB-
cord-334907-l4jjb93l	83	32	.	.	.
cord-334907-l4jjb93l	84	1	In	in	IN
cord-334907-l4jjb93l	84	2	our	-PRON-	PRP$
cord-334907-l4jjb93l	84	3	ISAV	ISAV	NNP
cord-334907-l4jjb93l	84	4	F	F	NNP
cord-334907-l4jjb93l	84	5	1	1	CD
cord-334907-l4jjb93l	84	6	model	model	NN
cord-334907-l4jjb93l	84	7	,	,	,
cord-334907-l4jjb93l	84	8	two	two	CD
cord-334907-l4jjb93l	84	9	phenylalanine	phenylalanine	NN
cord-334907-l4jjb93l	84	10	residues	residue	NNS
cord-334907-l4jjb93l	84	11	are	be	VBP
cord-334907-l4jjb93l	84	12	located	locate	VBN
cord-334907-l4jjb93l	84	13	in	in	IN
cord-334907-l4jjb93l	84	14	this	this	DT
cord-334907-l4jjb93l	84	15	area	area	NN
cord-334907-l4jjb93l	84	16	and	and	CC
cord-334907-l4jjb93l	84	17	thus	thus	RB
cord-334907-l4jjb93l	84	18	may	may	MD
cord-334907-l4jjb93l	84	19	play	play	VB
cord-334907-l4jjb93l	84	20	a	a	DT
cord-334907-l4jjb93l	84	21	role	role	NN
cord-334907-l4jjb93l	84	22	in	in	IN
cord-334907-l4jjb93l	84	23	the	the	DT
cord-334907-l4jjb93l	84	24	interaction	interaction	NN
cord-334907-l4jjb93l	84	25	with	with	IN
cord-334907-l4jjb93l	84	26	a	a	DT
cord-334907-l4jjb93l	84	27	potential	potential	JJ
cord-334907-l4jjb93l	84	28	receptor	receptor	NN
cord-334907-l4jjb93l	84	29	.	.	.
cord-334907-l4jjb93l	85	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	85	2	2020	2020	CD
cord-334907-l4jjb93l	85	3	,	,	,
cord-334907-l4jjb93l	85	4	9	9	CD
cord-334907-l4jjb93l	85	5	,	,	,
cord-334907-l4jjb93l	85	6	x	x	NN
cord-334907-l4jjb93l	85	7	FOR	for	IN
cord-334907-l4jjb93l	85	8	PEER	peer	NN
cord-334907-l4jjb93l	85	9	REVIEW	REVIEW	NNP
cord-334907-l4jjb93l	85	10	4	4	CD
cord-334907-l4jjb93l	85	11	of	of	IN
cord-334907-l4jjb93l	85	12	18	18	CD
cord-334907-l4jjb93l	85	13	similar	similar	JJ
cord-334907-l4jjb93l	85	14	to	to	IN
cord-334907-l4jjb93l	85	15	viral	viral	JJ
cord-334907-l4jjb93l	85	16	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	85	17	.	.	.
cord-334907-l4jjb93l	86	1	In	in	IN
cord-334907-l4jjb93l	86	2	canonical	canonical	JJ
cord-334907-l4jjb93l	86	3	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	86	4	,	,	,
cord-334907-l4jjb93l	86	5	residues	residue	NNS
cord-334907-l4jjb93l	86	6	located	locate	VBN
cord-334907-l4jjb93l	86	7	at	at	IN
cord-334907-l4jjb93l	86	8	the	the	DT
cord-334907-l4jjb93l	86	9	loops	loop	NNS
cord-334907-l4jjb93l	86	10	connecting	connect	VBG
cord-334907-l4jjb93l	86	11	the	the	DT
cord-334907-l4jjb93l	86	12	beta	beta	NN
cord-334907-l4jjb93l	86	13	strands	strand	NNS
cord-334907-l4jjb93l	86	14	are	be	VBP
cord-334907-l4jjb93l	86	15	involved	involve	VBN
cord-334907-l4jjb93l	86	16	in	in	IN
cord-334907-l4jjb93l	86	17	ligand	ligand	NN
cord-334907-l4jjb93l	86	18	binding	binding	NN
cord-334907-l4jjb93l	86	19	,	,	,
cord-334907-l4jjb93l	86	20	with	with	IN
cord-334907-l4jjb93l	86	21	a	a	DT
cord-334907-l4jjb93l	86	22	hydrophobic	hydrophobic	JJ
cord-334907-l4jjb93l	86	23	pocket	pocket	NN
cord-334907-l4jjb93l	86	24	commonly	commonly	RB
cord-334907-l4jjb93l	86	25	interacting	interact	VBG
cord-334907-l4jjb93l	86	26	with	with	IN
cord-334907-l4jjb93l	86	27	the	the	DT
cord-334907-l4jjb93l	86	28	glycan	glycan	NN
cord-334907-l4jjb93l	86	29	[	[	-LRB-
cord-334907-l4jjb93l	86	30	33	33	CD
cord-334907-l4jjb93l	86	31	]	]	-RRB-
cord-334907-l4jjb93l	86	32	.	.	.
cord-334907-l4jjb93l	87	1	In	in	IN
cord-334907-l4jjb93l	87	2	our	-PRON-	PRP$
cord-334907-l4jjb93l	87	3	ISAV	ISAV	NNP
cord-334907-l4jjb93l	87	4	F1	F1	NNP
cord-334907-l4jjb93l	87	5	model	model	NN
cord-334907-l4jjb93l	87	6	,	,	,
cord-334907-l4jjb93l	87	7	two	two	CD
cord-334907-l4jjb93l	87	8	phenylalanine	phenylalanine	NN
cord-334907-l4jjb93l	87	9	residues	residue	NNS
cord-334907-l4jjb93l	87	10	are	be	VBP
cord-334907-l4jjb93l	87	11	located	locate	VBN
cord-334907-l4jjb93l	87	12	in	in	IN
cord-334907-l4jjb93l	87	13	this	this	DT
cord-334907-l4jjb93l	87	14	area	area	NN
cord-334907-l4jjb93l	87	15	and	and	CC
cord-334907-l4jjb93l	87	16	thus	thus	RB
cord-334907-l4jjb93l	87	17	may	may	MD
cord-334907-l4jjb93l	87	18	play	play	VB
cord-334907-l4jjb93l	87	19	a	a	DT
cord-334907-l4jjb93l	87	20	role	role	NN
cord-334907-l4jjb93l	87	21	in	in	IN
cord-334907-l4jjb93l	87	22	the	the	DT
cord-334907-l4jjb93l	87	23	interaction	interaction	NN
cord-334907-l4jjb93l	87	24	with	with	IN
cord-334907-l4jjb93l	87	25	a	a	DT
cord-334907-l4jjb93l	87	26	potential	potential	JJ
cord-334907-l4jjb93l	87	27	receptor	receptor	NN
cord-334907-l4jjb93l	87	28	.	.	.
cord-334907-l4jjb93l	87	29	 	 	_SP
cord-334907-l4jjb93l	88	1	To	to	TO
cord-334907-l4jjb93l	88	2	assess	assess	VB
cord-334907-l4jjb93l	88	3	the	the	DT
cord-334907-l4jjb93l	88	4	direct	direct	JJ
cord-334907-l4jjb93l	88	5	interaction	interaction	NN
cord-334907-l4jjb93l	88	6	of	of	IN
cord-334907-l4jjb93l	88	7	ISAF	ISAF	NNP
cord-334907-l4jjb93l	88	8	F	F	NNP
cord-334907-l4jjb93l	88	9	,	,	,
cord-334907-l4jjb93l	88	10	and	and	CC
cord-334907-l4jjb93l	88	11	HE	HE	NNP
cord-334907-l4jjb93l	88	12	,	,	,
cord-334907-l4jjb93l	88	13	with	with	IN
cord-334907-l4jjb93l	88	14	the	the	DT
cord-334907-l4jjb93l	88	15	cell	cell	NN
cord-334907-l4jjb93l	88	16	surface	surface	NN
cord-334907-l4jjb93l	88	17	,	,	,
cord-334907-l4jjb93l	88	18	we	-PRON-	PRP
cord-334907-l4jjb93l	88	19	used	use	VBD
cord-334907-l4jjb93l	88	20	purified	purify	VBN
cord-334907-l4jjb93l	88	21	3xFLAG	3xflag	CD
cord-334907-l4jjb93l	88	22	-	-	HYPH
cord-334907-l4jjb93l	88	23	tagged	tag	VBN
cord-334907-l4jjb93l	88	24	soluble	soluble	JJ
cord-334907-l4jjb93l	88	25	versions	version	NNS
cord-334907-l4jjb93l	88	26	of	of	IN
cord-334907-l4jjb93l	88	27	ISAV	ISAV	NNP
cord-334907-l4jjb93l	88	28	HE	HE	NNP
cord-334907-l4jjb93l	88	29	and	and	CC
cord-334907-l4jjb93l	88	30	F	F	NNP
cord-334907-l4jjb93l	88	31	(	(	-LRB-
cord-334907-l4jjb93l	88	32	rHE	rHE	NNP
cord-334907-l4jjb93l	88	33	and	and	CC
cord-334907-l4jjb93l	88	34	rF	rF	NNP
cord-334907-l4jjb93l	88	35	)	)	-RRB-
cord-334907-l4jjb93l	88	36	in	in	IN
cord-334907-l4jjb93l	88	37	lectin	lectin	NN
cord-334907-l4jjb93l	88	38	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	88	39	assays	assay	NNS
cord-334907-l4jjb93l	88	40	,	,	,
cord-334907-l4jjb93l	88	41	using	use	VBG
cord-334907-l4jjb93l	88	42	ASK	ask	NN
cord-334907-l4jjb93l	88	43	cells	cell	NNS
cord-334907-l4jjb93l	88	44	as	as	IN
cord-334907-l4jjb93l	88	45	targets	target	NNS
cord-334907-l4jjb93l	88	46	[	[	-LRB-
cord-334907-l4jjb93l	88	47	35	35	CD
cord-334907-l4jjb93l	88	48	]	]	-RRB-
cord-334907-l4jjb93l	88	49	.	.	.
cord-334907-l4jjb93l	89	1	Indeed	indeed	RB
cord-334907-l4jjb93l	89	2	,	,	,
cord-334907-l4jjb93l	89	3	both	both	CC
cord-334907-l4jjb93l	89	4	rHE	rHE	NNP
cord-334907-l4jjb93l	89	5	and	and	CC
cord-334907-l4jjb93l	89	6	rF	rF	NNP
cord-334907-l4jjb93l	89	7	effectively	effectively	RB
cord-334907-l4jjb93l	89	8	interacted	interact	VBD
cord-334907-l4jjb93l	89	9	with	with	IN
cord-334907-l4jjb93l	89	10	the	the	DT
cord-334907-l4jjb93l	89	11	cell	cell	NN
cord-334907-l4jjb93l	89	12	surface	surface	NN
cord-334907-l4jjb93l	89	13	,	,	,
cord-334907-l4jjb93l	89	14	as	as	IN
cord-334907-l4jjb93l	89	15	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	89	16	by	by	IN
cord-334907-l4jjb93l	89	17	the	the	DT
cord-334907-l4jjb93l	89	18	fluorescent	fluorescent	NN
cord-334907-l4jjb93l	89	19	stain	stain	NN
cord-334907-l4jjb93l	89	20	pattern	pattern	NN
cord-334907-l4jjb93l	89	21	(	(	-LRB-
cord-334907-l4jjb93l	89	22	Figure	figure	NN
cord-334907-l4jjb93l	89	23	3a	3a	NN
cord-334907-l4jjb93l	89	24	,	,	,
cord-334907-l4jjb93l	89	25	b	b	NN
cord-334907-l4jjb93l	89	26	)	)	-RRB-
cord-334907-l4jjb93l	89	27	.	.	.
cord-334907-l4jjb93l	90	1	ASK	ask	VB
cord-334907-l4jjb93l	90	2	cells	cell	NNS
cord-334907-l4jjb93l	90	3	pretreatment	pretreatment	JJ
cord-334907-l4jjb93l	90	4	with	with	IN
cord-334907-l4jjb93l	90	5	NaOH	NaOH	NNP
cord-334907-l4jjb93l	90	6	(	(	-LRB-
cord-334907-l4jjb93l	90	7	i.e.	i.e.	FW
cord-334907-l4jjb93l	90	8	,	,	,
cord-334907-l4jjb93l	90	9	saponification	saponification	NN
cord-334907-l4jjb93l	90	10	)	)	-RRB-
cord-334907-l4jjb93l	90	11	impeded	impede	VBD
cord-334907-l4jjb93l	90	12	the	the	DT
cord-334907-l4jjb93l	90	13	interaction	interaction	NN
cord-334907-l4jjb93l	90	14	of	of	IN
cord-334907-l4jjb93l	90	15	rF	rf	NN
cord-334907-l4jjb93l	90	16	with	with	IN
cord-334907-l4jjb93l	90	17	the	the	DT
cord-334907-l4jjb93l	90	18	cell	cell	NN
cord-334907-l4jjb93l	90	19	,	,	,
cord-334907-l4jjb93l	90	20	suggesting	suggest	VBG
cord-334907-l4jjb93l	90	21	that	that	IN
cord-334907-l4jjb93l	90	22	the	the	DT
cord-334907-l4jjb93l	90	23	receptor	receptor	NN
cord-334907-l4jjb93l	90	24	for	for	IN
cord-334907-l4jjb93l	90	25	F	F	NNP
cord-334907-l4jjb93l	90	26	may	may	MD
cord-334907-l4jjb93l	90	27	correspond	correspond	VB
cord-334907-l4jjb93l	90	28	to	to	IN
cord-334907-l4jjb93l	90	29	a	a	DT
cord-334907-l4jjb93l	90	30	sialic	sialic	JJ
cord-334907-l4jjb93l	90	31	acid	acid	NN
cord-334907-l4jjb93l	90	32	,	,	,
cord-334907-l4jjb93l	90	33	as	as	IN
cord-334907-l4jjb93l	90	34	has	have	VBZ
cord-334907-l4jjb93l	90	35	been	be	VBN
cord-334907-l4jjb93l	90	36	already	already	RB
cord-334907-l4jjb93l	90	37	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	90	38	for	for	IN
cord-334907-l4jjb93l	90	39	ISAV	ISAV	NNP
cord-334907-l4jjb93l	90	40	HE	HE	NNP
cord-334907-l4jjb93l	90	41	(	(	-LRB-
cord-334907-l4jjb93l	90	42	Figure	Figure	NNP
cord-334907-l4jjb93l	90	43	3d	3d	NNP
cord-334907-l4jjb93l	90	44	)	)	-RRB-
cord-334907-l4jjb93l	91	1	[	[	-LRB-
cord-334907-l4jjb93l	91	2	27	27	CD
cord-334907-l4jjb93l	91	3	]	]	-RRB-
cord-334907-l4jjb93l	91	4	.	.	.
cord-334907-l4jjb93l	92	1	Moreover	moreover	RB
cord-334907-l4jjb93l	92	2	,	,	,
cord-334907-l4jjb93l	92	3	preincubation	preincubation	NN
cord-334907-l4jjb93l	92	4	of	of	IN
cord-334907-l4jjb93l	92	5	the	the	DT
cord-334907-l4jjb93l	92	6	cells	cell	NNS
cord-334907-l4jjb93l	92	7	with	with	IN
cord-334907-l4jjb93l	92	8	soluble	soluble	JJ
cord-334907-l4jjb93l	92	9	HE	HE	NNP
cord-334907-l4jjb93l	92	10	blocked	block	VBD
cord-334907-l4jjb93l	92	11	the	the	DT
cord-334907-l4jjb93l	92	12	adhesion	adhesion	NN
cord-334907-l4jjb93l	92	13	of	of	IN
cord-334907-l4jjb93l	92	14	rF	rf	NN
cord-334907-l4jjb93l	92	15	to	to	IN
cord-334907-l4jjb93l	92	16	the	the	DT
cord-334907-l4jjb93l	92	17	cell	cell	NN
cord-334907-l4jjb93l	92	18	surface	surface	NN
cord-334907-l4jjb93l	92	19	,	,	,
cord-334907-l4jjb93l	92	20	and	and	CC
cord-334907-l4jjb93l	92	21	chemical	chemical	JJ
cord-334907-l4jjb93l	92	22	pre	pre	NN
cord-334907-l4jjb93l	92	23	-	-	NN
cord-334907-l4jjb93l	92	24	inactivation	inactivation	JJ
cord-334907-l4jjb93l	92	25	of	of	IN
cord-334907-l4jjb93l	92	26	the	the	DT
cord-334907-l4jjb93l	92	27	esterase	esterase	NN
cord-334907-l4jjb93l	92	28	on	on	IN
cord-334907-l4jjb93l	92	29	rHE	rHE	NNP
cord-334907-l4jjb93l	92	30	by	by	IN
cord-334907-l4jjb93l	92	31	DCIC	DCIC	NNP
cord-334907-l4jjb93l	92	32	treatment	treatment	NN
cord-334907-l4jjb93l	92	33	eliminated	eliminate	VBD
cord-334907-l4jjb93l	92	34	the	the	DT
cord-334907-l4jjb93l	92	35	blockage	blockage	NN
cord-334907-l4jjb93l	92	36	,	,	,
cord-334907-l4jjb93l	92	37	suggesting	suggest	VBG
cord-334907-l4jjb93l	92	38	that	that	IN
cord-334907-l4jjb93l	92	39	the	the	DT
cord-334907-l4jjb93l	92	40	initial	initial	JJ
cord-334907-l4jjb93l	92	41	effect	effect	NN
cord-334907-l4jjb93l	92	42	was	be	VBD
cord-334907-l4jjb93l	92	43	not	not	RB
cord-334907-l4jjb93l	92	44	due	due	JJ
cord-334907-l4jjb93l	92	45	to	to	IN
cord-334907-l4jjb93l	92	46	ligand	ligand	NN
cord-334907-l4jjb93l	92	47	competition	competition	NN
cord-334907-l4jjb93l	92	48	,	,	,
cord-334907-l4jjb93l	92	49	but	but	CC
cord-334907-l4jjb93l	92	50	rather	rather	RB
cord-334907-l4jjb93l	92	51	to	to	IN
cord-334907-l4jjb93l	92	52	the	the	DT
cord-334907-l4jjb93l	92	53	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	92	54	activity	activity	NN
cord-334907-l4jjb93l	92	55	of	of	IN
cord-334907-l4jjb93l	92	56	rHE	rHE	NNP
cord-334907-l4jjb93l	92	57	(	(	-LRB-
cord-334907-l4jjb93l	92	58	i.e.	i.e.	FW
cord-334907-l4jjb93l	92	59	,	,	,
cord-334907-l4jjb93l	92	60	esterase	esterase	NN
cord-334907-l4jjb93l	92	61	)	)	-RRB-
cord-334907-l4jjb93l	92	62	over	over	IN
cord-334907-l4jjb93l	92	63	the	the	DT
cord-334907-l4jjb93l	92	64	rF	rf	NN
cord-334907-l4jjb93l	92	65	receptor	receptor	NN
cord-334907-l4jjb93l	92	66	(	(	-LRB-
cord-334907-l4jjb93l	92	67	Figure	Figure	NNP
cord-334907-l4jjb93l	92	68	3e	3e	NNP
cord-334907-l4jjb93l	92	69	,	,	,
cord-334907-l4jjb93l	92	70	f	f	NNP
cord-334907-l4jjb93l	92	71	)	)	-RRB-
cord-334907-l4jjb93l	92	72	.	.	.
cord-334907-l4jjb93l	93	1	These	these	DT
cord-334907-l4jjb93l	93	2	results	result	NNS
cord-334907-l4jjb93l	93	3	suggest	suggest	VBP
cord-334907-l4jjb93l	93	4	a	a	DT
cord-334907-l4jjb93l	93	5	direct	direct	JJ
cord-334907-l4jjb93l	93	6	interaction	interaction	NN
cord-334907-l4jjb93l	93	7	of	of	IN
cord-334907-l4jjb93l	93	8	F	F	NNP
cord-334907-l4jjb93l	93	9	with	with	IN
cord-334907-l4jjb93l	93	10	the	the	DT
cord-334907-l4jjb93l	93	11	cell	cell	NN
cord-334907-l4jjb93l	93	12	surface	surface	NN
cord-334907-l4jjb93l	93	13	and	and	CC
cord-334907-l4jjb93l	93	14	,	,	,
cord-334907-l4jjb93l	93	15	furthermore	furthermore	RB
cord-334907-l4jjb93l	93	16	,	,	,
cord-334907-l4jjb93l	93	17	with	with	IN
cord-334907-l4jjb93l	93	18	a	a	DT
cord-334907-l4jjb93l	93	19	sialic	sialic	JJ
cord-334907-l4jjb93l	93	20	acid	acid	NN
cord-334907-l4jjb93l	93	21	receptor	receptor	NN
cord-334907-l4jjb93l	93	22	,	,	,
cord-334907-l4jjb93l	93	23	considering	consider	VBG
cord-334907-l4jjb93l	93	24	the	the	DT
cord-334907-l4jjb93l	93	25	results	result	NNS
cord-334907-l4jjb93l	93	26	of	of	IN
cord-334907-l4jjb93l	93	27	the	the	DT
cord-334907-l4jjb93l	93	28	saponification	saponification	NN
cord-334907-l4jjb93l	93	29	and	and	CC
cord-334907-l4jjb93l	93	30	DCIC	DCIC	NNP
cord-334907-l4jjb93l	93	31	assays	assay	NNS
cord-334907-l4jjb93l	93	32	.	.	.
cord-334907-l4jjb93l	94	1	To	to	TO
cord-334907-l4jjb93l	94	2	confirm	confirm	VB
cord-334907-l4jjb93l	94	3	the	the	DT
cord-334907-l4jjb93l	94	4	interaction	interaction	NN
cord-334907-l4jjb93l	94	5	of	of	IN
cord-334907-l4jjb93l	94	6	HE	HE	NNP
cord-334907-l4jjb93l	94	7	and	and	CC
cord-334907-l4jjb93l	94	8	F	F	NNP
cord-334907-l4jjb93l	94	9	with	with	IN
cord-334907-l4jjb93l	94	10	their	-PRON-	PRP$
cord-334907-l4jjb93l	94	11	cell	cell	NN
cord-334907-l4jjb93l	94	12	receptors	receptor	NNS
cord-334907-l4jjb93l	94	13	,	,	,
cord-334907-l4jjb93l	94	14	ASK	ask	VB
cord-334907-l4jjb93l	94	15	cells	cell	NNS
cord-334907-l4jjb93l	94	16	were	be	VBD
cord-334907-l4jjb93l	94	17	pretreated	pretreate	VBN
cord-334907-l4jjb93l	94	18	with	with	IN
cord-334907-l4jjb93l	94	19	rHE	rHE	NNP
cord-334907-l4jjb93l	94	20	and/or	and/or	CC
cord-334907-l4jjb93l	94	21	rF	rF	NNP
cord-334907-l4jjb93l	94	22	,	,	,
cord-334907-l4jjb93l	94	23	prior	prior	RB
cord-334907-l4jjb93l	94	24	to	to	IN
cord-334907-l4jjb93l	94	25	cell	cell	NN
cord-334907-l4jjb93l	94	26	infection	infection	NN
cord-334907-l4jjb93l	94	27	.	.	.
cord-334907-l4jjb93l	95	1	After	after	IN
cord-334907-l4jjb93l	95	2	48	48	CD
cord-334907-l4jjb93l	95	3	h	h	NN
cord-334907-l4jjb93l	95	4	,	,	,
cord-334907-l4jjb93l	95	5	ISAV	ISAV	NNP
cord-334907-l4jjb93l	95	6	gene	gene	NN
cord-334907-l4jjb93l	95	7	expression	expression	NN
cord-334907-l4jjb93l	95	8	was	be	VBD
cord-334907-l4jjb93l	95	9	used	use	VBN
cord-334907-l4jjb93l	95	10	to	to	TO
cord-334907-l4jjb93l	95	11	evaluate	evaluate	VB
cord-334907-l4jjb93l	95	12	the	the	DT
cord-334907-l4jjb93l	95	13	level	level	NN
cord-334907-l4jjb93l	95	14	of	of	IN
cord-334907-l4jjb93l	95	15	infection	infection	NN
cord-334907-l4jjb93l	95	16	compared	compare	VBN
cord-334907-l4jjb93l	95	17	to	to	IN
cord-334907-l4jjb93l	95	18	mock	mock	VB
cord-334907-l4jjb93l	95	19	-	-	HYPH
cord-334907-l4jjb93l	95	20	treated	treat	VBN
cord-334907-l4jjb93l	95	21	controls	control	NNS
cord-334907-l4jjb93l	95	22	.	.	.
cord-334907-l4jjb93l	96	1	Figure	figure	NN
cord-334907-l4jjb93l	96	2	4	4	CD
cord-334907-l4jjb93l	96	3	shows	show	VBZ
cord-334907-l4jjb93l	96	4	the	the	DT
cord-334907-l4jjb93l	96	5	qRT	qRT	NNP
cord-334907-l4jjb93l	96	6	-	-	HYPH
cord-334907-l4jjb93l	96	7	PCR	PCR	NNP
cord-334907-l4jjb93l	96	8	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	96	9	profiles	profile	NNS
cord-334907-l4jjb93l	96	10	obtained	obtain	VBN
cord-334907-l4jjb93l	96	11	in	in	IN
cord-334907-l4jjb93l	96	12	each	each	DT
cord-334907-l4jjb93l	96	13	assay	assay	NN
cord-334907-l4jjb93l	96	14	.	.	.
cord-334907-l4jjb93l	97	1	The	the	DT
cord-334907-l4jjb93l	97	2	three	three	CD
cord-334907-l4jjb93l	97	3	treatments	treatment	NNS
cord-334907-l4jjb93l	97	4	had	have	VBD
cord-334907-l4jjb93l	97	5	a	a	DT
cord-334907-l4jjb93l	97	6	significant	significant	JJ
cord-334907-l4jjb93l	97	7	negative	negative	JJ
cord-334907-l4jjb93l	97	8	effect	effect	NN
cord-334907-l4jjb93l	97	9	over	over	IN
cord-334907-l4jjb93l	97	10	the	the	DT
cord-334907-l4jjb93l	97	11	viral	viral	JJ
cord-334907-l4jjb93l	97	12	infection	infection	NN
cord-334907-l4jjb93l	97	13	compared	compare	VBN
cord-334907-l4jjb93l	97	14	to	to	IN
cord-334907-l4jjb93l	97	15	the	the	DT
cord-334907-l4jjb93l	97	16	untreated	untreated	JJ
cord-334907-l4jjb93l	97	17	control	control	NN
cord-334907-l4jjb93l	97	18	,	,	,
cord-334907-l4jjb93l	97	19	with	with	IN
cord-334907-l4jjb93l	97	20	a	a	DT
cord-334907-l4jjb93l	97	21	pronounced	pronounced	JJ
cord-334907-l4jjb93l	97	22	effect	effect	NN
cord-334907-l4jjb93l	97	23	for	for	IN
cord-334907-l4jjb93l	97	24	the	the	DT
cord-334907-l4jjb93l	97	25	rHE	rHE	NNP
cord-334907-l4jjb93l	97	26	treatment	treatment	NN
cord-334907-l4jjb93l	97	27	(	(	-LRB-
cord-334907-l4jjb93l	97	28	77	77	CD
cord-334907-l4jjb93l	97	29	%	%	NN
cord-334907-l4jjb93l	97	30	inhibition	inhibition	NN
cord-334907-l4jjb93l	97	31	)	)	-RRB-
cord-334907-l4jjb93l	97	32	,	,	,
cord-334907-l4jjb93l	97	33	a	a	DT
cord-334907-l4jjb93l	97	34	lower	low	JJR
cord-334907-l4jjb93l	97	35	effect	effect	NN
cord-334907-l4jjb93l	97	36	for	for	IN
cord-334907-l4jjb93l	97	37	rF	rf	NN
cord-334907-l4jjb93l	97	38	(	(	-LRB-
cord-334907-l4jjb93l	97	39	41.3	41.3	CD
cord-334907-l4jjb93l	97	40	%	%	NN
cord-334907-l4jjb93l	97	41	inhibition	inhibition	NN
cord-334907-l4jjb93l	97	42	)	)	-RRB-
cord-334907-l4jjb93l	97	43	,	,	,
cord-334907-l4jjb93l	97	44	and	and	CC
cord-334907-l4jjb93l	97	45	the	the	DT
cord-334907-l4jjb93l	97	46	highest	high	JJS
cord-334907-l4jjb93l	97	47	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	97	48	effect	effect	NN
cord-334907-l4jjb93l	97	49	for	for	IN
cord-334907-l4jjb93l	97	50	the	the	DT
cord-334907-l4jjb93l	97	51	treatment	treatment	NN
cord-334907-l4jjb93l	97	52	with	with	IN
cord-334907-l4jjb93l	97	53	a	a	DT
cord-334907-l4jjb93l	97	54	(	(	-LRB-
cord-334907-l4jjb93l	97	55	a	a	DT
cord-334907-l4jjb93l	97	56	)	)	-RRB-
cord-334907-l4jjb93l	97	57	Secondary	secondary	JJ
cord-334907-l4jjb93l	97	58	structure	structure	NN
cord-334907-l4jjb93l	97	59	-	-	HYPH
cord-334907-l4jjb93l	97	60	based	base	VBN
cord-334907-l4jjb93l	97	61	sequence	sequence	NN
cord-334907-l4jjb93l	97	62	alignment	alignment	NN
cord-334907-l4jjb93l	97	63	of	of	IN
cord-334907-l4jjb93l	97	64	the	the	DT
cord-334907-l4jjb93l	97	65	PToV	PToV	NNP
cord-334907-l4jjb93l	97	66	HE	HE	NNP
cord-334907-l4jjb93l	97	67	sequence	sequence	NN
cord-334907-l4jjb93l	97	68	(	(	-LRB-
cord-334907-l4jjb93l	97	69	3ilk	3ilk	NFP
cord-334907-l4jjb93l	97	70	)	)	-RRB-
cord-334907-l4jjb93l	97	71	and	and	CC
cord-334907-l4jjb93l	97	72	the	the	DT
cord-334907-l4jjb93l	97	73	ISAV	ISAV	NNP
cord-334907-l4jjb93l	97	74	F	F	NNP
cord-334907-l4jjb93l	97	75	1	1	CD
cord-334907-l4jjb93l	97	76	domain	domain	NN
cord-334907-l4jjb93l	97	77	.	.	.
cord-334907-l4jjb93l	98	1	The	the	DT
cord-334907-l4jjb93l	98	2	alignment	alignment	NN
cord-334907-l4jjb93l	98	3	was	be	VBD
cord-334907-l4jjb93l	98	4	used	use	VBN
cord-334907-l4jjb93l	98	5	to	to	TO
cord-334907-l4jjb93l	98	6	build	build	VB
cord-334907-l4jjb93l	98	7	a	a	DT
cord-334907-l4jjb93l	98	8	structural	structural	JJ
cord-334907-l4jjb93l	98	9	model	model	NN
cord-334907-l4jjb93l	98	10	using	use	VBG
cord-334907-l4jjb93l	98	11	MODELLER	MODELLER	NNP
cord-334907-l4jjb93l	98	12	[	[	-LRB-
cord-334907-l4jjb93l	98	13	34	34	CD
cord-334907-l4jjb93l	98	14	]	]	-RRB-
cord-334907-l4jjb93l	98	15	.	.	.
cord-334907-l4jjb93l	99	1	Beta	beta	JJ
cord-334907-l4jjb93l	99	2	strands	strand	NNS
cord-334907-l4jjb93l	99	3	and	and	CC
cord-334907-l4jjb93l	99	4	alpha	alpha	NN
cord-334907-l4jjb93l	99	5	helices	helix	NNS
cord-334907-l4jjb93l	99	6	are	be	VBP
cord-334907-l4jjb93l	99	7	indicated	indicate	VBN
cord-334907-l4jjb93l	99	8	in	in	IN
cord-334907-l4jjb93l	99	9	red	red	JJ
cord-334907-l4jjb93l	99	10	and	and	CC
cord-334907-l4jjb93l	99	11	blue	blue	JJ
cord-334907-l4jjb93l	99	12	arrows	arrow	NNS
cord-334907-l4jjb93l	99	13	,	,	,
cord-334907-l4jjb93l	99	14	respectively	respectively	RB
cord-334907-l4jjb93l	99	15	.	.	.
cord-334907-l4jjb93l	100	1	The	the	DT
cord-334907-l4jjb93l	100	2	green	green	JJ
cord-334907-l4jjb93l	100	3	arrowhead	arrowhead	NN
cord-334907-l4jjb93l	100	4	indicates	indicate	VBZ
cord-334907-l4jjb93l	100	5	the	the	DT
cord-334907-l4jjb93l	100	6	position	position	NN
cord-334907-l4jjb93l	100	7	of	of	IN
cord-334907-l4jjb93l	100	8	relevant	relevant	JJ
cord-334907-l4jjb93l	100	9	Phe	Phe	NNP
cord-334907-l4jjb93l	100	10	residues	residue	NNS
cord-334907-l4jjb93l	100	11	(	(	-LRB-
cord-334907-l4jjb93l	100	12	b	b	NN
cord-334907-l4jjb93l	100	13	)	)	-RRB-
cord-334907-l4jjb93l	101	1	The	the	DT
cord-334907-l4jjb93l	101	2	theoretical	theoretical	JJ
cord-334907-l4jjb93l	101	3	structure	structure	NN
cord-334907-l4jjb93l	101	4	for	for	IN
cord-334907-l4jjb93l	101	5	F	F	NNP
cord-334907-l4jjb93l	101	6	1	1	CD
cord-334907-l4jjb93l	101	7	displays	display	VBZ
cord-334907-l4jjb93l	101	8	a	a	DT
cord-334907-l4jjb93l	101	9	conserved	conserved	JJ
cord-334907-l4jjb93l	101	10	Swiss	swiss	JJ
cord-334907-l4jjb93l	101	11	roll	roll	NN
cord-334907-l4jjb93l	101	12	conformation	conformation	NN
cord-334907-l4jjb93l	101	13	.	.	.
cord-334907-l4jjb93l	102	1	Phe	Phe	NNP
cord-334907-l4jjb93l	102	2	residues	residue	NNS
cord-334907-l4jjb93l	102	3	at	at	IN
cord-334907-l4jjb93l	102	4	positions	position	NNS
cord-334907-l4jjb93l	102	5	183	183	CD
cord-334907-l4jjb93l	102	6	and	and	CC
cord-334907-l4jjb93l	102	7	227	227	CD
cord-334907-l4jjb93l	102	8	,	,	,
cord-334907-l4jjb93l	102	9	possibly	possibly	RB
cord-334907-l4jjb93l	102	10	involved	involve	VBN
cord-334907-l4jjb93l	102	11	in	in	IN
cord-334907-l4jjb93l	102	12	receptor	receptor	NN
cord-334907-l4jjb93l	102	13	binding	binding	NN
cord-334907-l4jjb93l	102	14	,	,	,
cord-334907-l4jjb93l	102	15	are	be	VBP
cord-334907-l4jjb93l	102	16	depicted	depict	VBN
cord-334907-l4jjb93l	102	17	in	in	IN
cord-334907-l4jjb93l	102	18	ball	ball	NN
cord-334907-l4jjb93l	102	19	and	and	CC
cord-334907-l4jjb93l	102	20	stick	stick	NN
cord-334907-l4jjb93l	102	21	representation	representation	NN
cord-334907-l4jjb93l	102	22	.	.	.
cord-334907-l4jjb93l	103	1	To	to	TO
cord-334907-l4jjb93l	103	2	assess	assess	VB
cord-334907-l4jjb93l	103	3	the	the	DT
cord-334907-l4jjb93l	103	4	direct	direct	JJ
cord-334907-l4jjb93l	103	5	interaction	interaction	NN
cord-334907-l4jjb93l	103	6	of	of	IN
cord-334907-l4jjb93l	103	7	ISAF	ISAF	NNP
cord-334907-l4jjb93l	103	8	F	F	NNP
cord-334907-l4jjb93l	103	9	,	,	,
cord-334907-l4jjb93l	103	10	and	and	CC
cord-334907-l4jjb93l	103	11	HE	HE	NNP
cord-334907-l4jjb93l	103	12	,	,	,
cord-334907-l4jjb93l	103	13	with	with	IN
cord-334907-l4jjb93l	103	14	the	the	DT
cord-334907-l4jjb93l	103	15	cell	cell	NN
cord-334907-l4jjb93l	103	16	surface	surface	NN
cord-334907-l4jjb93l	103	17	,	,	,
cord-334907-l4jjb93l	103	18	we	-PRON-	PRP
cord-334907-l4jjb93l	103	19	used	use	VBD
cord-334907-l4jjb93l	103	20	purified	purify	VBN
cord-334907-l4jjb93l	103	21	3xFLAG	3xflag	CD
cord-334907-l4jjb93l	103	22	-	-	HYPH
cord-334907-l4jjb93l	103	23	tagged	tag	VBN
cord-334907-l4jjb93l	103	24	soluble	soluble	JJ
cord-334907-l4jjb93l	103	25	versions	version	NNS
cord-334907-l4jjb93l	103	26	of	of	IN
cord-334907-l4jjb93l	103	27	ISAV	ISAV	NNP
cord-334907-l4jjb93l	103	28	HE	HE	NNP
cord-334907-l4jjb93l	103	29	and	and	CC
cord-334907-l4jjb93l	103	30	F	F	NNP
cord-334907-l4jjb93l	103	31	(	(	-LRB-
cord-334907-l4jjb93l	103	32	rHE	rHE	NNP
cord-334907-l4jjb93l	103	33	and	and	CC
cord-334907-l4jjb93l	103	34	rF	rF	NNP
cord-334907-l4jjb93l	103	35	)	)	-RRB-
cord-334907-l4jjb93l	103	36	in	in	IN
cord-334907-l4jjb93l	103	37	lectin	lectin	NN
cord-334907-l4jjb93l	103	38	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	103	39	assays	assay	NNS
cord-334907-l4jjb93l	103	40	,	,	,
cord-334907-l4jjb93l	103	41	using	use	VBG
cord-334907-l4jjb93l	103	42	ASK	ask	NN
cord-334907-l4jjb93l	103	43	cells	cell	NNS
cord-334907-l4jjb93l	103	44	as	as	IN
cord-334907-l4jjb93l	103	45	targets	target	NNS
cord-334907-l4jjb93l	103	46	[	[	-LRB-
cord-334907-l4jjb93l	103	47	35	35	CD
cord-334907-l4jjb93l	103	48	]	]	-RRB-
cord-334907-l4jjb93l	103	49	.	.	.
cord-334907-l4jjb93l	104	1	Indeed	indeed	RB
cord-334907-l4jjb93l	104	2	,	,	,
cord-334907-l4jjb93l	104	3	both	both	CC
cord-334907-l4jjb93l	104	4	rHE	rHE	NNP
cord-334907-l4jjb93l	104	5	and	and	CC
cord-334907-l4jjb93l	104	6	rF	rF	NNP
cord-334907-l4jjb93l	104	7	effectively	effectively	RB
cord-334907-l4jjb93l	104	8	interacted	interact	VBD
cord-334907-l4jjb93l	104	9	with	with	IN
cord-334907-l4jjb93l	104	10	the	the	DT
cord-334907-l4jjb93l	104	11	cell	cell	NN
cord-334907-l4jjb93l	104	12	surface	surface	NN
cord-334907-l4jjb93l	104	13	,	,	,
cord-334907-l4jjb93l	104	14	as	as	IN
cord-334907-l4jjb93l	104	15	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	104	16	by	by	IN
cord-334907-l4jjb93l	104	17	the	the	DT
cord-334907-l4jjb93l	104	18	fluorescent	fluorescent	NN
cord-334907-l4jjb93l	104	19	stain	stain	NN
cord-334907-l4jjb93l	104	20	pattern	pattern	NN
cord-334907-l4jjb93l	104	21	(	(	-LRB-
cord-334907-l4jjb93l	104	22	Figure	figure	NN
cord-334907-l4jjb93l	104	23	3a	3a	NN
cord-334907-l4jjb93l	104	24	,	,	,
cord-334907-l4jjb93l	104	25	b	b	NN
cord-334907-l4jjb93l	104	26	)	)	-RRB-
cord-334907-l4jjb93l	104	27	.	.	.
cord-334907-l4jjb93l	105	1	ASK	ask	VB
cord-334907-l4jjb93l	105	2	cells	cell	NNS
cord-334907-l4jjb93l	105	3	pretreatment	pretreatment	JJ
cord-334907-l4jjb93l	105	4	with	with	IN
cord-334907-l4jjb93l	105	5	NaOH	NaOH	NNP
cord-334907-l4jjb93l	105	6	(	(	-LRB-
cord-334907-l4jjb93l	105	7	i.e.	i.e.	FW
cord-334907-l4jjb93l	105	8	,	,	,
cord-334907-l4jjb93l	105	9	saponification	saponification	NN
cord-334907-l4jjb93l	105	10	)	)	-RRB-
cord-334907-l4jjb93l	105	11	impeded	impede	VBD
cord-334907-l4jjb93l	105	12	the	the	DT
cord-334907-l4jjb93l	105	13	interaction	interaction	NN
cord-334907-l4jjb93l	105	14	of	of	IN
cord-334907-l4jjb93l	105	15	rF	rf	NN
cord-334907-l4jjb93l	105	16	with	with	IN
cord-334907-l4jjb93l	105	17	the	the	DT
cord-334907-l4jjb93l	105	18	cell	cell	NN
cord-334907-l4jjb93l	105	19	,	,	,
cord-334907-l4jjb93l	105	20	suggesting	suggest	VBG
cord-334907-l4jjb93l	105	21	that	that	IN
cord-334907-l4jjb93l	105	22	the	the	DT
cord-334907-l4jjb93l	105	23	receptor	receptor	NN
cord-334907-l4jjb93l	105	24	for	for	IN
cord-334907-l4jjb93l	105	25	F	F	NNP
cord-334907-l4jjb93l	105	26	may	may	MD
cord-334907-l4jjb93l	105	27	correspond	correspond	VB
cord-334907-l4jjb93l	105	28	to	to	IN
cord-334907-l4jjb93l	105	29	a	a	DT
cord-334907-l4jjb93l	105	30	sialic	sialic	JJ
cord-334907-l4jjb93l	105	31	acid	acid	NN
cord-334907-l4jjb93l	105	32	,	,	,
cord-334907-l4jjb93l	105	33	as	as	IN
cord-334907-l4jjb93l	105	34	has	have	VBZ
cord-334907-l4jjb93l	105	35	been	be	VBN
cord-334907-l4jjb93l	105	36	already	already	RB
cord-334907-l4jjb93l	105	37	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	105	38	for	for	IN
cord-334907-l4jjb93l	105	39	ISAV	ISAV	NNP
cord-334907-l4jjb93l	105	40	HE	HE	NNP
cord-334907-l4jjb93l	105	41	(	(	-LRB-
cord-334907-l4jjb93l	105	42	Figure	Figure	NNP
cord-334907-l4jjb93l	105	43	3d	3d	NNP
cord-334907-l4jjb93l	105	44	)	)	-RRB-
cord-334907-l4jjb93l	106	1	[	[	-LRB-
cord-334907-l4jjb93l	106	2	27	27	CD
cord-334907-l4jjb93l	106	3	]	]	-RRB-
cord-334907-l4jjb93l	106	4	.	.	.
cord-334907-l4jjb93l	107	1	Moreover	moreover	RB
cord-334907-l4jjb93l	107	2	,	,	,
cord-334907-l4jjb93l	107	3	preincubation	preincubation	NN
cord-334907-l4jjb93l	107	4	of	of	IN
cord-334907-l4jjb93l	107	5	the	the	DT
cord-334907-l4jjb93l	107	6	cells	cell	NNS
cord-334907-l4jjb93l	107	7	with	with	IN
cord-334907-l4jjb93l	107	8	soluble	soluble	JJ
cord-334907-l4jjb93l	107	9	HE	HE	NNP
cord-334907-l4jjb93l	107	10	blocked	block	VBD
cord-334907-l4jjb93l	107	11	the	the	DT
cord-334907-l4jjb93l	107	12	adhesion	adhesion	NN
cord-334907-l4jjb93l	107	13	of	of	IN
cord-334907-l4jjb93l	107	14	rF	rf	NN
cord-334907-l4jjb93l	107	15	to	to	IN
cord-334907-l4jjb93l	107	16	the	the	DT
cord-334907-l4jjb93l	107	17	cell	cell	NN
cord-334907-l4jjb93l	107	18	surface	surface	NN
cord-334907-l4jjb93l	107	19	,	,	,
cord-334907-l4jjb93l	107	20	and	and	CC
cord-334907-l4jjb93l	107	21	chemical	chemical	JJ
cord-334907-l4jjb93l	107	22	pre	pre	NN
cord-334907-l4jjb93l	107	23	-	-	NN
cord-334907-l4jjb93l	107	24	inactivation	inactivation	JJ
cord-334907-l4jjb93l	107	25	of	of	IN
cord-334907-l4jjb93l	107	26	the	the	DT
cord-334907-l4jjb93l	107	27	esterase	esterase	NN
cord-334907-l4jjb93l	107	28	on	on	IN
cord-334907-l4jjb93l	107	29	rHE	rHE	NNP
cord-334907-l4jjb93l	107	30	by	by	IN
cord-334907-l4jjb93l	107	31	DCIC	DCIC	NNP
cord-334907-l4jjb93l	107	32	treatment	treatment	NN
cord-334907-l4jjb93l	107	33	eliminated	eliminate	VBD
cord-334907-l4jjb93l	107	34	the	the	DT
cord-334907-l4jjb93l	107	35	blockage	blockage	NN
cord-334907-l4jjb93l	107	36	,	,	,
cord-334907-l4jjb93l	107	37	suggesting	suggest	VBG
cord-334907-l4jjb93l	107	38	that	that	IN
cord-334907-l4jjb93l	107	39	the	the	DT
cord-334907-l4jjb93l	107	40	initial	initial	JJ
cord-334907-l4jjb93l	107	41	effect	effect	NN
cord-334907-l4jjb93l	107	42	was	be	VBD
cord-334907-l4jjb93l	107	43	not	not	RB
cord-334907-l4jjb93l	107	44	due	due	JJ
cord-334907-l4jjb93l	107	45	to	to	IN
cord-334907-l4jjb93l	107	46	ligand	ligand	NN
cord-334907-l4jjb93l	107	47	competition	competition	NN
cord-334907-l4jjb93l	107	48	,	,	,
cord-334907-l4jjb93l	107	49	but	but	CC
cord-334907-l4jjb93l	107	50	rather	rather	RB
cord-334907-l4jjb93l	107	51	to	to	IN
cord-334907-l4jjb93l	107	52	the	the	DT
cord-334907-l4jjb93l	107	53	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	107	54	activity	activity	NN
cord-334907-l4jjb93l	107	55	of	of	IN
cord-334907-l4jjb93l	107	56	rHE	rHE	NNP
cord-334907-l4jjb93l	107	57	(	(	-LRB-
cord-334907-l4jjb93l	107	58	i.e.	i.e.	FW
cord-334907-l4jjb93l	107	59	,	,	,
cord-334907-l4jjb93l	107	60	esterase	esterase	NN
cord-334907-l4jjb93l	107	61	)	)	-RRB-
cord-334907-l4jjb93l	107	62	over	over	IN
cord-334907-l4jjb93l	107	63	the	the	DT
cord-334907-l4jjb93l	107	64	rF	rf	NN
cord-334907-l4jjb93l	107	65	receptor	receptor	NN
cord-334907-l4jjb93l	107	66	(	(	-LRB-
cord-334907-l4jjb93l	107	67	Figure	Figure	NNP
cord-334907-l4jjb93l	107	68	3e	3e	NNP
cord-334907-l4jjb93l	107	69	,	,	,
cord-334907-l4jjb93l	107	70	f	f	NNP
cord-334907-l4jjb93l	107	71	)	)	-RRB-
cord-334907-l4jjb93l	107	72	.	.	.
cord-334907-l4jjb93l	108	1	These	these	DT
cord-334907-l4jjb93l	108	2	results	result	NNS
cord-334907-l4jjb93l	108	3	suggest	suggest	VBP
cord-334907-l4jjb93l	108	4	a	a	DT
cord-334907-l4jjb93l	108	5	direct	direct	JJ
cord-334907-l4jjb93l	108	6	interaction	interaction	NN
cord-334907-l4jjb93l	108	7	of	of	IN
cord-334907-l4jjb93l	108	8	F	F	NNP
cord-334907-l4jjb93l	108	9	with	with	IN
cord-334907-l4jjb93l	108	10	the	the	DT
cord-334907-l4jjb93l	108	11	cell	cell	NN
cord-334907-l4jjb93l	108	12	surface	surface	NN
cord-334907-l4jjb93l	108	13	and	and	CC
cord-334907-l4jjb93l	108	14	,	,	,
cord-334907-l4jjb93l	108	15	furthermore	furthermore	RB
cord-334907-l4jjb93l	108	16	,	,	,
cord-334907-l4jjb93l	108	17	with	with	IN
cord-334907-l4jjb93l	108	18	a	a	DT
cord-334907-l4jjb93l	108	19	sialic	sialic	JJ
cord-334907-l4jjb93l	108	20	acid	acid	NN
cord-334907-l4jjb93l	108	21	receptor	receptor	NN
cord-334907-l4jjb93l	108	22	,	,	,
cord-334907-l4jjb93l	108	23	considering	consider	VBG
cord-334907-l4jjb93l	108	24	the	the	DT
cord-334907-l4jjb93l	108	25	results	result	NNS
cord-334907-l4jjb93l	108	26	of	of	IN
cord-334907-l4jjb93l	108	27	the	the	DT
cord-334907-l4jjb93l	108	28	saponification	saponification	NN
cord-334907-l4jjb93l	108	29	and	and	CC
cord-334907-l4jjb93l	108	30	DCIC	DCIC	NNP
cord-334907-l4jjb93l	108	31	assays	assay	NNS
cord-334907-l4jjb93l	108	32	.	.	.
cord-334907-l4jjb93l	109	1	To	to	TO
cord-334907-l4jjb93l	109	2	confirm	confirm	VB
cord-334907-l4jjb93l	109	3	the	the	DT
cord-334907-l4jjb93l	109	4	interaction	interaction	NN
cord-334907-l4jjb93l	109	5	of	of	IN
cord-334907-l4jjb93l	109	6	HE	HE	NNP
cord-334907-l4jjb93l	109	7	and	and	CC
cord-334907-l4jjb93l	109	8	F	F	NNP
cord-334907-l4jjb93l	109	9	with	with	IN
cord-334907-l4jjb93l	109	10	their	-PRON-	PRP$
cord-334907-l4jjb93l	109	11	cell	cell	NN
cord-334907-l4jjb93l	109	12	receptors	receptor	NNS
cord-334907-l4jjb93l	109	13	,	,	,
cord-334907-l4jjb93l	109	14	ASK	ask	VB
cord-334907-l4jjb93l	109	15	cells	cell	NNS
cord-334907-l4jjb93l	109	16	were	be	VBD
cord-334907-l4jjb93l	109	17	pretreated	pretreate	VBN
cord-334907-l4jjb93l	109	18	with	with	IN
cord-334907-l4jjb93l	109	19	rHE	rHE	NNP
cord-334907-l4jjb93l	109	20	and/or	and/or	CC
cord-334907-l4jjb93l	109	21	rF	rF	NNP
cord-334907-l4jjb93l	109	22	,	,	,
cord-334907-l4jjb93l	109	23	prior	prior	RB
cord-334907-l4jjb93l	109	24	to	to	IN
cord-334907-l4jjb93l	109	25	cell	cell	NN
cord-334907-l4jjb93l	109	26	infection	infection	NN
cord-334907-l4jjb93l	109	27	.	.	.
cord-334907-l4jjb93l	110	1	After	after	IN
cord-334907-l4jjb93l	110	2	48	48	CD
cord-334907-l4jjb93l	110	3	h	h	NN
cord-334907-l4jjb93l	110	4	,	,	,
cord-334907-l4jjb93l	110	5	ISAV	ISAV	NNP
cord-334907-l4jjb93l	110	6	gene	gene	NN
cord-334907-l4jjb93l	110	7	expression	expression	NN
cord-334907-l4jjb93l	110	8	was	be	VBD
cord-334907-l4jjb93l	110	9	used	use	VBN
cord-334907-l4jjb93l	110	10	to	to	TO
cord-334907-l4jjb93l	110	11	evaluate	evaluate	VB
cord-334907-l4jjb93l	110	12	the	the	DT
cord-334907-l4jjb93l	110	13	level	level	NN
cord-334907-l4jjb93l	110	14	of	of	IN
cord-334907-l4jjb93l	110	15	infection	infection	NN
cord-334907-l4jjb93l	110	16	compared	compare	VBN
cord-334907-l4jjb93l	110	17	to	to	IN
cord-334907-l4jjb93l	110	18	mock	mock	VB
cord-334907-l4jjb93l	110	19	-	-	HYPH
cord-334907-l4jjb93l	110	20	treated	treat	VBN
cord-334907-l4jjb93l	110	21	controls	control	NNS
cord-334907-l4jjb93l	110	22	.	.	.
cord-334907-l4jjb93l	111	1	Figure	figure	NN
cord-334907-l4jjb93l	111	2	4	4	CD
cord-334907-l4jjb93l	111	3	shows	show	VBZ
cord-334907-l4jjb93l	111	4	the	the	DT
cord-334907-l4jjb93l	111	5	qRT	qRT	NNP
cord-334907-l4jjb93l	111	6	-	-	HYPH
cord-334907-l4jjb93l	111	7	PCR	PCR	NNP
cord-334907-l4jjb93l	111	8	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	111	9	profiles	profile	NNS
cord-334907-l4jjb93l	111	10	obtained	obtain	VBN
cord-334907-l4jjb93l	111	11	in	in	IN
cord-334907-l4jjb93l	111	12	each	each	DT
cord-334907-l4jjb93l	111	13	assay	assay	NN
cord-334907-l4jjb93l	111	14	.	.	.
cord-334907-l4jjb93l	112	1	The	the	DT
cord-334907-l4jjb93l	112	2	three	three	CD
cord-334907-l4jjb93l	112	3	treatments	treatment	NNS
cord-334907-l4jjb93l	112	4	had	have	VBD
cord-334907-l4jjb93l	112	5	a	a	DT
cord-334907-l4jjb93l	112	6	significant	significant	JJ
cord-334907-l4jjb93l	112	7	negative	negative	JJ
cord-334907-l4jjb93l	112	8	effect	effect	NN
cord-334907-l4jjb93l	112	9	over	over	IN
cord-334907-l4jjb93l	112	10	the	the	DT
cord-334907-l4jjb93l	112	11	viral	viral	JJ
cord-334907-l4jjb93l	112	12	infection	infection	NN
cord-334907-l4jjb93l	112	13	compared	compare	VBN
cord-334907-l4jjb93l	112	14	to	to	IN
cord-334907-l4jjb93l	112	15	the	the	DT
cord-334907-l4jjb93l	112	16	untreated	untreated	JJ
cord-334907-l4jjb93l	112	17	control	control	NN
cord-334907-l4jjb93l	112	18	,	,	,
cord-334907-l4jjb93l	112	19	with	with	IN
cord-334907-l4jjb93l	112	20	a	a	DT
cord-334907-l4jjb93l	112	21	pronounced	pronounced	JJ
cord-334907-l4jjb93l	112	22	effect	effect	NN
cord-334907-l4jjb93l	112	23	for	for	IN
cord-334907-l4jjb93l	112	24	the	the	DT
cord-334907-l4jjb93l	112	25	rHE	rHE	NNP
cord-334907-l4jjb93l	112	26	treatment	treatment	NN
cord-334907-l4jjb93l	112	27	(	(	-LRB-
cord-334907-l4jjb93l	112	28	77	77	CD
cord-334907-l4jjb93l	112	29	%	%	NN
cord-334907-l4jjb93l	112	30	inhibition	inhibition	NN
cord-334907-l4jjb93l	112	31	)	)	-RRB-
cord-334907-l4jjb93l	112	32	,	,	,
cord-334907-l4jjb93l	112	33	a	a	DT
cord-334907-l4jjb93l	112	34	lower	low	JJR
cord-334907-l4jjb93l	112	35	effect	effect	NN
cord-334907-l4jjb93l	112	36	for	for	IN
cord-334907-l4jjb93l	112	37	rF	rf	NN
cord-334907-l4jjb93l	112	38	(	(	-LRB-
cord-334907-l4jjb93l	112	39	41.3	41.3	CD
cord-334907-l4jjb93l	112	40	%	%	NN
cord-334907-l4jjb93l	112	41	inhibition	inhibition	NN
cord-334907-l4jjb93l	112	42	)	)	-RRB-
cord-334907-l4jjb93l	112	43	,	,	,
cord-334907-l4jjb93l	112	44	and	and	CC
cord-334907-l4jjb93l	112	45	the	the	DT
cord-334907-l4jjb93l	112	46	highest	high	JJS
cord-334907-l4jjb93l	112	47	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	112	48	effect	effect	NN
cord-334907-l4jjb93l	112	49	for	for	IN
cord-334907-l4jjb93l	112	50	the	the	DT
cord-334907-l4jjb93l	112	51	treatment	treatment	NN
cord-334907-l4jjb93l	112	52	with	with	IN
cord-334907-l4jjb93l	112	53	a	a	DT
cord-334907-l4jjb93l	112	54	combination	combination	NN
cord-334907-l4jjb93l	112	55	of	of	IN
cord-334907-l4jjb93l	112	56	the	the	DT
cord-334907-l4jjb93l	112	57	two	two	CD
cord-334907-l4jjb93l	112	58	lectins	lectin	NNS
cord-334907-l4jjb93l	112	59	(	(	-LRB-
cord-334907-l4jjb93l	112	60	90.3	90.3	CD
cord-334907-l4jjb93l	112	61	%	%	NN
cord-334907-l4jjb93l	112	62	inhibition	inhibition	NN
cord-334907-l4jjb93l	112	63	)	)	-RRB-
cord-334907-l4jjb93l	112	64	.	.	.
cord-334907-l4jjb93l	113	1	Notably	notably	RB
cord-334907-l4jjb93l	113	2	,	,	,
cord-334907-l4jjb93l	113	3	there	there	EX
cord-334907-l4jjb93l	113	4	was	be	VBD
cord-334907-l4jjb93l	113	5	a	a	DT
cord-334907-l4jjb93l	113	6	significant	significant	JJ
cord-334907-l4jjb93l	113	7	difference	difference	NN
cord-334907-l4jjb93l	113	8	between	between	IN
cord-334907-l4jjb93l	113	9	the	the	DT
cord-334907-l4jjb93l	113	10	double	double	JJ
cord-334907-l4jjb93l	113	11	-	-	HYPH
cord-334907-l4jjb93l	113	12	lectin	lectin	NN
cord-334907-l4jjb93l	113	13	treatment	treatment	NN
cord-334907-l4jjb93l	113	14	and	and	CC
cord-334907-l4jjb93l	113	15	each	each	DT
cord-334907-l4jjb93l	113	16	one	one	CD
cord-334907-l4jjb93l	113	17	of	of	IN
cord-334907-l4jjb93l	113	18	the	the	DT
cord-334907-l4jjb93l	113	19	single	single	JJ
cord-334907-l4jjb93l	113	20	-	-	HYPH
cord-334907-l4jjb93l	113	21	lectin	lectin	NN
cord-334907-l4jjb93l	113	22	treatments	treatment	NNS
cord-334907-l4jjb93l	113	23	,	,	,
cord-334907-l4jjb93l	113	24	suggesting	suggest	VBG
cord-334907-l4jjb93l	113	25	an	an	DT
cord-334907-l4jjb93l	113	26	additive	additive	NN
cord-334907-l4jjb93l	113	27	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	113	28	effect	effect	NN
cord-334907-l4jjb93l	113	29	on	on	IN
cord-334907-l4jjb93l	113	30	ISAV	ISAV	NNP
cord-334907-l4jjb93l	113	31	Pathogens	Pathogens	NNP
cord-334907-l4jjb93l	113	32	2020	2020	CD
cord-334907-l4jjb93l	113	33	,	,	,
cord-334907-l4jjb93l	113	34	9	9	CD
cord-334907-l4jjb93l	113	35	,	,	,
cord-334907-l4jjb93l	113	36	416	416	CD
cord-334907-l4jjb93l	113	37	5	5	CD
cord-334907-l4jjb93l	113	38	of	of	IN
cord-334907-l4jjb93l	113	39	18	18	CD
cord-334907-l4jjb93l	113	40	infection	infection	NN
cord-334907-l4jjb93l	113	41	for	for	IN
cord-334907-l4jjb93l	113	42	the	the	DT
cord-334907-l4jjb93l	113	43	rHE	rHE	NNP
cord-334907-l4jjb93l	113	44	/	/	SYM
cord-334907-l4jjb93l	113	45	rF	rf	NN
cord-334907-l4jjb93l	113	46	combination	combination	NN
cord-334907-l4jjb93l	113	47	(	(	-LRB-
cord-334907-l4jjb93l	113	48	Figure	figure	NN
cord-334907-l4jjb93l	113	49	3	3	CD
cord-334907-l4jjb93l	113	50	)	)	-RRB-
cord-334907-l4jjb93l	113	51	.	.	.
cord-334907-l4jjb93l	114	1	These	these	DT
cord-334907-l4jjb93l	114	2	results	result	NNS
cord-334907-l4jjb93l	114	3	confirm	confirm	VBP
cord-334907-l4jjb93l	114	4	the	the	DT
cord-334907-l4jjb93l	114	5	interaction	interaction	NN
cord-334907-l4jjb93l	114	6	of	of	IN
cord-334907-l4jjb93l	114	7	both	both	DT
cord-334907-l4jjb93l	114	8	viral	viral	JJ
cord-334907-l4jjb93l	114	9	proteins	protein	NNS
cord-334907-l4jjb93l	114	10	with	with	IN
cord-334907-l4jjb93l	114	11	the	the	DT
cord-334907-l4jjb93l	114	12	cell	cell	NN
cord-334907-l4jjb93l	114	13	surface	surface	NN
cord-334907-l4jjb93l	114	14	.	.	.
cord-334907-l4jjb93l	115	1	Moreover	moreover	RB
cord-334907-l4jjb93l	115	2	,	,	,
cord-334907-l4jjb93l	115	3	the	the	DT
cord-334907-l4jjb93l	115	4	interaction	interaction	NN
cord-334907-l4jjb93l	115	5	of	of	IN
cord-334907-l4jjb93l	115	6	each	each	DT
cord-334907-l4jjb93l	115	7	viral	viral	JJ
cord-334907-l4jjb93l	115	8	protein	protein	NN
cord-334907-l4jjb93l	115	9	with	with	IN
cord-334907-l4jjb93l	115	10	a	a	DT
cord-334907-l4jjb93l	115	11	specific	specific	JJ
cord-334907-l4jjb93l	115	12	receptor	receptor	NN
cord-334907-l4jjb93l	115	13	is	be	VBZ
cord-334907-l4jjb93l	115	14	confirmed	confirm	VBN
cord-334907-l4jjb93l	115	15	,	,	,
cord-334907-l4jjb93l	115	16	which	which	WDT
cord-334907-l4jjb93l	115	17	translates	translate	VBZ
cord-334907-l4jjb93l	115	18	in	in	IN
cord-334907-l4jjb93l	115	19	the	the	DT
cord-334907-l4jjb93l	115	20	blockage	blockage	NN
cord-334907-l4jjb93l	115	21	of	of	IN
cord-334907-l4jjb93l	115	22	infection	infection	NN
cord-334907-l4jjb93l	115	23	in	in	IN
cord-334907-l4jjb93l	115	24	this	this	DT
cord-334907-l4jjb93l	115	25	assay	assay	NN
cord-334907-l4jjb93l	115	26	.	.	.
cord-334907-l4jjb93l	116	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	116	2	2020	2020	CD
cord-334907-l4jjb93l	116	3	,	,	,
cord-334907-l4jjb93l	116	4	9	9	CD
cord-334907-l4jjb93l	116	5	,	,	,
cord-334907-l4jjb93l	116	6	x	x	NN
cord-334907-l4jjb93l	116	7	FOR	for	IN
cord-334907-l4jjb93l	116	8	PEER	peer	NN
cord-334907-l4jjb93l	116	9	REVIEW	REVIEW	NNP
cord-334907-l4jjb93l	116	10	5	5	CD
cord-334907-l4jjb93l	116	11	of	of	IN
cord-334907-l4jjb93l	116	12	18	18	CD
cord-334907-l4jjb93l	116	13	combination	combination	NN
cord-334907-l4jjb93l	116	14	of	of	IN
cord-334907-l4jjb93l	116	15	the	the	DT
cord-334907-l4jjb93l	116	16	two	two	CD
cord-334907-l4jjb93l	116	17	lectins	lectin	NNS
cord-334907-l4jjb93l	116	18	(	(	-LRB-
cord-334907-l4jjb93l	116	19	90.3	90.3	CD
cord-334907-l4jjb93l	116	20	%	%	NN
cord-334907-l4jjb93l	116	21	inhibition	inhibition	NN
cord-334907-l4jjb93l	116	22	)	)	-RRB-
cord-334907-l4jjb93l	116	23	.	.	.
cord-334907-l4jjb93l	117	1	Notably	notably	RB
cord-334907-l4jjb93l	117	2	,	,	,
cord-334907-l4jjb93l	117	3	there	there	EX
cord-334907-l4jjb93l	117	4	was	be	VBD
cord-334907-l4jjb93l	117	5	a	a	DT
cord-334907-l4jjb93l	117	6	significant	significant	JJ
cord-334907-l4jjb93l	117	7	difference	difference	NN
cord-334907-l4jjb93l	117	8	between	between	IN
cord-334907-l4jjb93l	117	9	the	the	DT
cord-334907-l4jjb93l	117	10	double	double	JJ
cord-334907-l4jjb93l	117	11	-	-	HYPH
cord-334907-l4jjb93l	117	12	lectin	lectin	NN
cord-334907-l4jjb93l	117	13	treatment	treatment	NN
cord-334907-l4jjb93l	117	14	and	and	CC
cord-334907-l4jjb93l	117	15	each	each	DT
cord-334907-l4jjb93l	117	16	one	one	CD
cord-334907-l4jjb93l	117	17	of	of	IN
cord-334907-l4jjb93l	117	18	the	the	DT
cord-334907-l4jjb93l	117	19	single	single	JJ
cord-334907-l4jjb93l	117	20	-	-	HYPH
cord-334907-l4jjb93l	117	21	lectin	lectin	NN
cord-334907-l4jjb93l	117	22	treatments	treatment	NNS
cord-334907-l4jjb93l	117	23	,	,	,
cord-334907-l4jjb93l	117	24	suggesting	suggest	VBG
cord-334907-l4jjb93l	117	25	an	an	DT
cord-334907-l4jjb93l	117	26	additive	additive	NN
cord-334907-l4jjb93l	117	27	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	117	28	effect	effect	NN
cord-334907-l4jjb93l	117	29	on	on	IN
cord-334907-l4jjb93l	117	30	ISAV	ISAV	NNP
cord-334907-l4jjb93l	117	31	infection	infection	NN
cord-334907-l4jjb93l	117	32	for	for	IN
cord-334907-l4jjb93l	117	33	the	the	DT
cord-334907-l4jjb93l	117	34	rHE	rHE	NNP
cord-334907-l4jjb93l	117	35	/	/	SYM
cord-334907-l4jjb93l	117	36	rF	rf	NN
cord-334907-l4jjb93l	117	37	combination	combination	NN
cord-334907-l4jjb93l	117	38	(	(	-LRB-
cord-334907-l4jjb93l	117	39	Figure	figure	NN
cord-334907-l4jjb93l	117	40	3	3	CD
cord-334907-l4jjb93l	117	41	)	)	-RRB-
cord-334907-l4jjb93l	117	42	.	.	.
cord-334907-l4jjb93l	118	1	These	these	DT
cord-334907-l4jjb93l	118	2	results	result	NNS
cord-334907-l4jjb93l	118	3	confirm	confirm	VBP
cord-334907-l4jjb93l	118	4	the	the	DT
cord-334907-l4jjb93l	118	5	interaction	interaction	NN
cord-334907-l4jjb93l	118	6	of	of	IN
cord-334907-l4jjb93l	118	7	both	both	DT
cord-334907-l4jjb93l	118	8	viral	viral	JJ
cord-334907-l4jjb93l	118	9	proteins	protein	NNS
cord-334907-l4jjb93l	118	10	with	with	IN
cord-334907-l4jjb93l	118	11	the	the	DT
cord-334907-l4jjb93l	118	12	cell	cell	NN
cord-334907-l4jjb93l	118	13	surface	surface	NN
cord-334907-l4jjb93l	118	14	.	.	.
cord-334907-l4jjb93l	119	1	Moreover	moreover	RB
cord-334907-l4jjb93l	119	2	,	,	,
cord-334907-l4jjb93l	119	3	the	the	DT
cord-334907-l4jjb93l	119	4	interaction	interaction	NN
cord-334907-l4jjb93l	119	5	of	of	IN
cord-334907-l4jjb93l	119	6	each	each	DT
cord-334907-l4jjb93l	119	7	viral	viral	JJ
cord-334907-l4jjb93l	119	8	protein	protein	NN
cord-334907-l4jjb93l	119	9	with	with	IN
cord-334907-l4jjb93l	119	10	a	a	DT
cord-334907-l4jjb93l	119	11	specific	specific	JJ
cord-334907-l4jjb93l	119	12	receptor	receptor	NN
cord-334907-l4jjb93l	119	13	is	be	VBZ
cord-334907-l4jjb93l	119	14	confirmed	confirm	VBN
cord-334907-l4jjb93l	119	15	,	,	,
cord-334907-l4jjb93l	119	16	which	which	WDT
cord-334907-l4jjb93l	119	17	translates	translate	VBZ
cord-334907-l4jjb93l	119	18	in	in	IN
cord-334907-l4jjb93l	119	19	the	the	DT
cord-334907-l4jjb93l	119	20	blockage	blockage	NN
cord-334907-l4jjb93l	119	21	of	of	IN
cord-334907-l4jjb93l	119	22	infection	infection	NN
cord-334907-l4jjb93l	119	23	in	in	IN
cord-334907-l4jjb93l	119	24	this	this	DT
cord-334907-l4jjb93l	119	25	assay	assay	NN
cord-334907-l4jjb93l	119	26	.	.	.
cord-334907-l4jjb93l	120	1	combination	combination	NN
cord-334907-l4jjb93l	120	2	of	of	IN
cord-334907-l4jjb93l	120	3	the	the	DT
cord-334907-l4jjb93l	120	4	two	two	CD
cord-334907-l4jjb93l	120	5	lectins	lectin	NNS
cord-334907-l4jjb93l	120	6	(	(	-LRB-
cord-334907-l4jjb93l	120	7	90.3	90.3	CD
cord-334907-l4jjb93l	120	8	%	%	NN
cord-334907-l4jjb93l	120	9	inhibition	inhibition	NN
cord-334907-l4jjb93l	120	10	)	)	-RRB-
cord-334907-l4jjb93l	120	11	.	.	.
cord-334907-l4jjb93l	121	1	Notably	notably	RB
cord-334907-l4jjb93l	121	2	,	,	,
cord-334907-l4jjb93l	121	3	there	there	EX
cord-334907-l4jjb93l	121	4	was	be	VBD
cord-334907-l4jjb93l	121	5	a	a	DT
cord-334907-l4jjb93l	121	6	significant	significant	JJ
cord-334907-l4jjb93l	121	7	difference	difference	NN
cord-334907-l4jjb93l	121	8	between	between	IN
cord-334907-l4jjb93l	121	9	the	the	DT
cord-334907-l4jjb93l	121	10	double	double	JJ
cord-334907-l4jjb93l	121	11	-	-	HYPH
cord-334907-l4jjb93l	121	12	lectin	lectin	NN
cord-334907-l4jjb93l	121	13	treatment	treatment	NN
cord-334907-l4jjb93l	121	14	and	and	CC
cord-334907-l4jjb93l	121	15	each	each	DT
cord-334907-l4jjb93l	121	16	one	one	CD
cord-334907-l4jjb93l	121	17	of	of	IN
cord-334907-l4jjb93l	121	18	the	the	DT
cord-334907-l4jjb93l	121	19	single	single	JJ
cord-334907-l4jjb93l	121	20	-	-	HYPH
cord-334907-l4jjb93l	121	21	lectin	lectin	NN
cord-334907-l4jjb93l	121	22	treatments	treatment	NNS
cord-334907-l4jjb93l	121	23	,	,	,
cord-334907-l4jjb93l	121	24	suggesting	suggest	VBG
cord-334907-l4jjb93l	121	25	an	an	DT
cord-334907-l4jjb93l	121	26	additive	additive	NN
cord-334907-l4jjb93l	121	27	inhibitory	inhibitory	JJ
cord-334907-l4jjb93l	121	28	effect	effect	NN
cord-334907-l4jjb93l	121	29	on	on	IN
cord-334907-l4jjb93l	121	30	ISAV	ISAV	NNP
cord-334907-l4jjb93l	121	31	infection	infection	NN
cord-334907-l4jjb93l	121	32	for	for	IN
cord-334907-l4jjb93l	121	33	the	the	DT
cord-334907-l4jjb93l	121	34	rHE	rHE	NNP
cord-334907-l4jjb93l	121	35	/	/	SYM
cord-334907-l4jjb93l	121	36	rF	rf	NN
cord-334907-l4jjb93l	121	37	combination	combination	NN
cord-334907-l4jjb93l	121	38	(	(	-LRB-
cord-334907-l4jjb93l	121	39	Figure	figure	NN
cord-334907-l4jjb93l	121	40	3	3	CD
cord-334907-l4jjb93l	121	41	)	)	-RRB-
cord-334907-l4jjb93l	121	42	.	.	.
cord-334907-l4jjb93l	122	1	These	these	DT
cord-334907-l4jjb93l	122	2	results	result	NNS
cord-334907-l4jjb93l	122	3	confirm	confirm	VBP
cord-334907-l4jjb93l	122	4	the	the	DT
cord-334907-l4jjb93l	122	5	interaction	interaction	NN
cord-334907-l4jjb93l	122	6	of	of	IN
cord-334907-l4jjb93l	122	7	both	both	DT
cord-334907-l4jjb93l	122	8	viral	viral	JJ
cord-334907-l4jjb93l	122	9	proteins	protein	NNS
cord-334907-l4jjb93l	122	10	with	with	IN
cord-334907-l4jjb93l	122	11	the	the	DT
cord-334907-l4jjb93l	122	12	cell	cell	NN
cord-334907-l4jjb93l	122	13	surface	surface	NN
cord-334907-l4jjb93l	122	14	.	.	.
cord-334907-l4jjb93l	123	1	Moreover	moreover	RB
cord-334907-l4jjb93l	123	2	,	,	,
cord-334907-l4jjb93l	123	3	the	the	DT
cord-334907-l4jjb93l	123	4	interaction	interaction	NN
cord-334907-l4jjb93l	123	5	of	of	IN
cord-334907-l4jjb93l	123	6	each	each	DT
cord-334907-l4jjb93l	123	7	viral	viral	JJ
cord-334907-l4jjb93l	123	8	protein	protein	NN
cord-334907-l4jjb93l	123	9	with	with	IN
cord-334907-l4jjb93l	123	10	a	a	DT
cord-334907-l4jjb93l	123	11	specific	specific	JJ
cord-334907-l4jjb93l	123	12	receptor	receptor	NN
cord-334907-l4jjb93l	123	13	is	be	VBZ
cord-334907-l4jjb93l	123	14	confirmed	confirm	VBN
cord-334907-l4jjb93l	123	15	,	,	,
cord-334907-l4jjb93l	123	16	which	which	WDT
cord-334907-l4jjb93l	123	17	translates	translate	VBZ
cord-334907-l4jjb93l	123	18	in	in	IN
cord-334907-l4jjb93l	123	19	the	the	DT
cord-334907-l4jjb93l	123	20	blockage	blockage	NN
cord-334907-l4jjb93l	123	21	of	of	IN
cord-334907-l4jjb93l	123	22	infection	infection	NN
cord-334907-l4jjb93l	123	23	in	in	IN
cord-334907-l4jjb93l	123	24	this	this	DT
cord-334907-l4jjb93l	123	25	assay	assay	NN
cord-334907-l4jjb93l	123	26	.	.	.
cord-334907-l4jjb93l	123	27	 	 	_SP
cord-334907-l4jjb93l	124	1	To	to	TO
cord-334907-l4jjb93l	124	2	assess	assess	VB
cord-334907-l4jjb93l	124	3	the	the	DT
cord-334907-l4jjb93l	124	4	role	role	NN
cord-334907-l4jjb93l	124	5	of	of	IN
cord-334907-l4jjb93l	124	6	the	the	DT
cord-334907-l4jjb93l	124	7	F	F	NNP
cord-334907-l4jjb93l	124	8	1	1	CD
cord-334907-l4jjb93l	124	9	domain	domain	NN
cord-334907-l4jjb93l	124	10	on	on	IN
cord-334907-l4jjb93l	124	11	the	the	DT
cord-334907-l4jjb93l	124	12	fusion	fusion	NN
cord-334907-l4jjb93l	124	13	activity	activity	NN
cord-334907-l4jjb93l	124	14	of	of	IN
cord-334907-l4jjb93l	124	15	F	F	NNP
cord-334907-l4jjb93l	124	16	,	,	,
cord-334907-l4jjb93l	124	17	different	different	JJ
cord-334907-l4jjb93l	124	18	ISAV	ISAV	NNP
cord-334907-l4jjb93l	124	19	HE	HE	NNP
cord-334907-l4jjb93l	124	20	and	and	CC
cord-334907-l4jjb93l	124	21	F	F	NNP
cord-334907-l4jjb93l	124	22	combinations	combination	NNS
cord-334907-l4jjb93l	124	23	were	be	VBD
cord-334907-l4jjb93l	124	24	evaluated	evaluate	VBN
cord-334907-l4jjb93l	124	25	in	in	IN
cord-334907-l4jjb93l	124	26	membrane	membrane	NN
cord-334907-l4jjb93l	124	27	fusion	fusion	NN
cord-334907-l4jjb93l	124	28	assays	assay	NNS
cord-334907-l4jjb93l	124	29	,	,	,
cord-334907-l4jjb93l	124	30	using	use	VBG
cord-334907-l4jjb93l	124	31	transfected	transfecte	VBN
cord-334907-l4jjb93l	124	32	CHSE	CHSE	NNP
cord-334907-l4jjb93l	124	33	/	/	SYM
cord-334907-l4jjb93l	124	34	F	F	NNP
cord-334907-l4jjb93l	124	35	cells	cell	NNS
cord-334907-l4jjb93l	124	36	expressing	express	VBG
cord-334907-l4jjb93l	124	37	the	the	DT
cord-334907-l4jjb93l	124	38	viral	viral	JJ
cord-334907-l4jjb93l	124	39	HE	HE	NNP
cord-334907-l4jjb93l	124	40	and	and	CC
cord-334907-l4jjb93l	124	41	F	F	NNP
cord-334907-l4jjb93l	124	42	proteins	protein	NNS
cord-334907-l4jjb93l	124	43	and	and	CC
cord-334907-l4jjb93l	124	44	R18-labeled	r18-labeled	JJ
cord-334907-l4jjb93l	124	45	salmon	salmon	NN
cord-334907-l4jjb93l	124	46	RBCs	rbc	NNS
cord-334907-l4jjb93l	124	47	.	.	.
cord-334907-l4jjb93l	125	1	After	after	IN
cord-334907-l4jjb93l	125	2	adhesion	adhesion	NN
cord-334907-l4jjb93l	125	3	,	,	,
cord-334907-l4jjb93l	125	4	cells	cell	NNS
cord-334907-l4jjb93l	125	5	were	be	VBD
cord-334907-l4jjb93l	125	6	subjected	subject	VBN
cord-334907-l4jjb93l	125	7	to	to	IN
cord-334907-l4jjb93l	125	8	trypsin	trypsin	NN
cord-334907-l4jjb93l	125	9	treatment	treatment	NN
cord-334907-l4jjb93l	125	10	and	and	CC
cord-334907-l4jjb93l	125	11	low	low	JJ
cord-334907-l4jjb93l	125	12	pH	ph	NN
cord-334907-l4jjb93l	125	13	to	to	TO
cord-334907-l4jjb93l	125	14	activate	activate	VB
cord-334907-l4jjb93l	125	15	the	the	DT
cord-334907-l4jjb93l	125	16	fusion	fusion	NN
cord-334907-l4jjb93l	125	17	mechanism	mechanism	NN
cord-334907-l4jjb93l	125	18	.	.	.
cord-334907-l4jjb93l	126	1	Fusion	fusion	NN
cord-334907-l4jjb93l	126	2	was	be	VBD
cord-334907-l4jjb93l	126	3	evident	evident	JJ
cord-334907-l4jjb93l	126	4	as	as	IN
cord-334907-l4jjb93l	126	5	the	the	DT
cord-334907-l4jjb93l	126	6	transference	transference	NN
cord-334907-l4jjb93l	126	7	of	of	IN
cord-334907-l4jjb93l	126	8	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	126	9	from	from	IN
cord-334907-l4jjb93l	126	10	the	the	DT
cord-334907-l4jjb93l	126	11	RBC	RBC	NNP
cord-334907-l4jjb93l	126	12	to	to	IN
cord-334907-l4jjb93l	126	13	the	the	DT
cord-334907-l4jjb93l	126	14	CHSE	CHSE	NNP
cord-334907-l4jjb93l	126	15	/	/	SYM
cord-334907-l4jjb93l	126	16	F	F	NNP
cord-334907-l4jjb93l	126	17	cell	cell	NN
cord-334907-l4jjb93l	126	18	.	.	.
cord-334907-l4jjb93l	127	1	We	-PRON-	PRP
cord-334907-l4jjb93l	127	2	assessed	assess	VBD
cord-334907-l4jjb93l	127	3	the	the	DT
cord-334907-l4jjb93l	127	4	level	level	NN
cord-334907-l4jjb93l	127	5	of	of	IN
cord-334907-l4jjb93l	127	6	expression	expression	NN
cord-334907-l4jjb93l	127	7	of	of	IN
cord-334907-l4jjb93l	127	8	every	every	DT
cord-334907-l4jjb93l	127	9	construct	construct	NN
cord-334907-l4jjb93l	127	10	,	,	,
cord-334907-l4jjb93l	127	11	using	use	VBG
cord-334907-l4jjb93l	127	12	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	127	13	assays	assay	NNS
cord-334907-l4jjb93l	127	14	,	,	,
cord-334907-l4jjb93l	127	15	and	and	CC
cord-334907-l4jjb93l	127	16	found	find	VBD
cord-334907-l4jjb93l	127	17	effective	effective	JJ
cord-334907-l4jjb93l	127	18	and	and	CC
cord-334907-l4jjb93l	127	19	comparable	comparable	JJ
cord-334907-l4jjb93l	127	20	expression	expression	NN
cord-334907-l4jjb93l	127	21	of	of	IN
cord-334907-l4jjb93l	127	22	all	all	DT
cord-334907-l4jjb93l	127	23	of	of	IN
cord-334907-l4jjb93l	127	24	them	-PRON-	PRP
cord-334907-l4jjb93l	127	25	(	(	-LRB-
cord-334907-l4jjb93l	127	26	Figures	figure	NNS
cord-334907-l4jjb93l	127	27	S1-S3	S1-S3	NNP
cord-334907-l4jjb93l	127	28	)	)	-RRB-
cord-334907-l4jjb93l	127	29	.	.	.
cord-334907-l4jjb93l	128	1	Hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	128	2	esterase	esterase	NN
cord-334907-l4jjb93l	128	3	and	and	CC
cord-334907-l4jjb93l	128	4	fusion	fusion	NN
cord-334907-l4jjb93l	128	5	protein	protein	NN
cord-334907-l4jjb93l	128	6	from	from	IN
cord-334907-l4jjb93l	128	7	the	the	DT
cord-334907-l4jjb93l	128	8	ISAV	ISAV	NNP
cord-334907-l4jjb93l	128	9	HPR3	HPR3	NNP
cord-334907-l4jjb93l	128	10	strain	strain	NN
cord-334907-l4jjb93l	128	11	were	be	VBD
cord-334907-l4jjb93l	128	12	used	use	VBN
cord-334907-l4jjb93l	128	13	as	as	IN
cord-334907-l4jjb93l	128	14	positive	positive	JJ
cord-334907-l4jjb93l	128	15	controls	control	NNS
cord-334907-l4jjb93l	128	16	and	and	CC
cord-334907-l4jjb93l	128	17	initially	initially	RB
cord-334907-l4jjb93l	128	18	compared	compare	VBN
cord-334907-l4jjb93l	128	19	to	to	IN
cord-334907-l4jjb93l	128	20	the	the	DT
cord-334907-l4jjb93l	128	21	HE0	HE0	NNP
cord-334907-l4jjb93l	128	22	/	/	SYM
cord-334907-l4jjb93l	128	23	F3	F3	NNP
cord-334907-l4jjb93l	128	24	combination	combination	NN
cord-334907-l4jjb93l	128	25	.	.	.
cord-334907-l4jjb93l	129	1	As	as	IN
cord-334907-l4jjb93l	129	2	previously	previously	RB
cord-334907-l4jjb93l	129	3	described	describe	VBN
cord-334907-l4jjb93l	129	4	,	,	,
cord-334907-l4jjb93l	129	5	HE0	HE0	NNP
cord-334907-l4jjb93l	129	6	is	be	VBZ
cord-334907-l4jjb93l	129	7	associated	associate	VBN
cord-334907-l4jjb93l	129	8	with	with	IN
cord-334907-l4jjb93l	129	9	a	a	DT
cord-334907-l4jjb93l	129	10	less	less	RBR
cord-334907-l4jjb93l	129	11	efficient	efficient	JJ
cord-334907-l4jjb93l	129	12	fusion	fusion	NN
cord-334907-l4jjb93l	129	13	system	system	NN
cord-334907-l4jjb93l	129	14	,	,	,
cord-334907-l4jjb93l	129	15	with	with	IN
cord-334907-l4jjb93l	129	16	4	4	CD
cord-334907-l4jjb93l	129	17	%	%	NN
cord-334907-l4jjb93l	129	18	of	of	IN
cord-334907-l4jjb93l	129	19	fusion	fusion	NN
cord-334907-l4jjb93l	129	20	,	,	,
cord-334907-l4jjb93l	129	21	compared	compare	VBN
cord-334907-l4jjb93l	129	22	to	to	IN
cord-334907-l4jjb93l	129	23	the	the	DT
cord-334907-l4jjb93l	129	24	88	88	CD
cord-334907-l4jjb93l	129	25	%	%	NN
cord-334907-l4jjb93l	129	26	of	of	IN
cord-334907-l4jjb93l	129	27	the	the	DT
cord-334907-l4jjb93l	129	28	positive	positive	JJ
cord-334907-l4jjb93l	129	29	control	control	NN
cord-334907-l4jjb93l	129	30	(	(	-LRB-
cord-334907-l4jjb93l	129	31	Figure	figure	NN
cord-334907-l4jjb93l	129	32	5a	5a	CD
cord-334907-l4jjb93l	129	33	)	)	-RRB-
cord-334907-l4jjb93l	129	34	.	.	.
cord-334907-l4jjb93l	130	1	To	to	TO
cord-334907-l4jjb93l	130	2	evaluate	evaluate	VB
cord-334907-l4jjb93l	130	3	the	the	DT
cord-334907-l4jjb93l	130	4	role	role	NN
cord-334907-l4jjb93l	130	5	of	of	IN
cord-334907-l4jjb93l	130	6	Phe183	phe183	CD
cord-334907-l4jjb93l	130	7	and	and	CC
cord-334907-l4jjb93l	130	8	Phe227	Phe227	NNS
cord-334907-l4jjb93l	130	9	from	from	IN
cord-334907-l4jjb93l	130	10	F	F	NNP
cord-334907-l4jjb93l	130	11	1	1	CD
cord-334907-l4jjb93l	130	12	in	in	IN
cord-334907-l4jjb93l	130	13	the	the	DT
cord-334907-l4jjb93l	130	14	fusion	fusion	NN
cord-334907-l4jjb93l	130	15	mechanism	mechanism	NN
cord-334907-l4jjb93l	130	16	,	,	,
cord-334907-l4jjb93l	130	17	F3	F3	NNP
cord-334907-l4jjb93l	130	18	mutants	mutant	NNS
cord-334907-l4jjb93l	130	19	were	be	VBD
cord-334907-l4jjb93l	130	20	developed	develop	VBN
cord-334907-l4jjb93l	130	21	,	,	,
cord-334907-l4jjb93l	130	22	carrying	carry	VBG
cord-334907-l4jjb93l	130	23	Phe	Phe	NNP
cord-334907-l4jjb93l	130	24	to	to	IN
cord-334907-l4jjb93l	130	25	Ile	Ile	NNP
cord-334907-l4jjb93l	130	26	mutations	mutation	NNS
cord-334907-l4jjb93l	130	27	(	(	-LRB-
cord-334907-l4jjb93l	130	28	Table	table	NN
cord-334907-l4jjb93l	130	29	1	1	CD
cord-334907-l4jjb93l	130	30	)	)	-RRB-
cord-334907-l4jjb93l	130	31	.	.	.
cord-334907-l4jjb93l	131	1	Both	both	DT
cord-334907-l4jjb93l	131	2	residues	residue	NNS
cord-334907-l4jjb93l	131	3	seem	seem	VBP
cord-334907-l4jjb93l	131	4	to	to	TO
cord-334907-l4jjb93l	131	5	have	have	VB
cord-334907-l4jjb93l	131	6	an	an	DT
cord-334907-l4jjb93l	131	7	important	important	JJ
cord-334907-l4jjb93l	131	8	role	role	NN
cord-334907-l4jjb93l	131	9	in	in	IN
cord-334907-l4jjb93l	131	10	the	the	DT
cord-334907-l4jjb93l	131	11	protein	protein	NN
cord-334907-l4jjb93l	131	12	functionality	functionality	NN
cord-334907-l4jjb93l	131	13	,	,	,
cord-334907-l4jjb93l	131	14	with	with	IN
cord-334907-l4jjb93l	131	15	the	the	DT
cord-334907-l4jjb93l	131	16	Phe183Ile	Phe183Ile	NNP
cord-334907-l4jjb93l	131	17	mutation	mutation	NN
cord-334907-l4jjb93l	131	18	reducing	reduce	VBG
cord-334907-l4jjb93l	131	19	the	the	DT
cord-334907-l4jjb93l	131	20	fusion	fusion	NN
cord-334907-l4jjb93l	131	21	activity	activity	NN
cord-334907-l4jjb93l	131	22	to	to	IN
cord-334907-l4jjb93l	131	23	a	a	DT
cord-334907-l4jjb93l	131	24	7.1	7.1	CD
cord-334907-l4jjb93l	131	25	%	%	NN
cord-334907-l4jjb93l	131	26	,	,	,
cord-334907-l4jjb93l	131	27	the	the	DT
cord-334907-l4jjb93l	131	28	Phe227Ile	Phe227Ile	NNP
cord-334907-l4jjb93l	131	29	mutation	mutation	NN
cord-334907-l4jjb93l	131	30	reducing	reduce	VBG
cord-334907-l4jjb93l	131	31	fusion	fusion	NN
cord-334907-l4jjb93l	131	32	activity	activity	NN
cord-334907-l4jjb93l	131	33	to	to	IN
cord-334907-l4jjb93l	131	34	a	a	DT
cord-334907-l4jjb93l	131	35	43.7	43.7	CD
cord-334907-l4jjb93l	131	36	%	%	NN
cord-334907-l4jjb93l	131	37	,	,	,
cord-334907-l4jjb93l	131	38	and	and	CC
cord-334907-l4jjb93l	131	39	the	the	DT
cord-334907-l4jjb93l	131	40	double	double	JJ
cord-334907-l4jjb93l	131	41	mutant	mutant	NN
cord-334907-l4jjb93l	131	42	completely	completely	RB
cord-334907-l4jjb93l	131	43	eliminating	eliminate	VBG
cord-334907-l4jjb93l	131	44	the	the	DT
cord-334907-l4jjb93l	131	45	fusion	fusion	NN
cord-334907-l4jjb93l	131	46	activity	activity	NN
cord-334907-l4jjb93l	131	47	(	(	-LRB-
cord-334907-l4jjb93l	131	48	Figure	figure	NN
cord-334907-l4jjb93l	131	49	5b	5b	CD
cord-334907-l4jjb93l	131	50	)	)	-RRB-
cord-334907-l4jjb93l	131	51	.	.	.
cord-334907-l4jjb93l	132	1	These	these	DT
cord-334907-l4jjb93l	132	2	results	result	NNS
cord-334907-l4jjb93l	132	3	demonstrate	demonstrate	VBP
cord-334907-l4jjb93l	132	4	an	an	DT
cord-334907-l4jjb93l	132	5	important	important	JJ
cord-334907-l4jjb93l	132	6	role	role	NN
cord-334907-l4jjb93l	132	7	for	for	IN
cord-334907-l4jjb93l	132	8	these	these	DT
cord-334907-l4jjb93l	132	9	two	two	CD
cord-334907-l4jjb93l	132	10	residues	residue	NNS
cord-334907-l4jjb93l	132	11	,	,	,
cord-334907-l4jjb93l	132	12	and	and	CC
cord-334907-l4jjb93l	132	13	the	the	DT
cord-334907-l4jjb93l	132	14	F	F	NNP
cord-334907-l4jjb93l	132	15	1	1	CD
cord-334907-l4jjb93l	132	16	domain	domain	NN
cord-334907-l4jjb93l	132	17	,	,	,
cord-334907-l4jjb93l	132	18	in	in	IN
cord-334907-l4jjb93l	132	19	the	the	DT
cord-334907-l4jjb93l	132	20	protein	protein	NN
cord-334907-l4jjb93l	132	21	functionality	functionality	NN
cord-334907-l4jjb93l	132	22	and	and	CC
cord-334907-l4jjb93l	132	23	further	further	RB
cord-334907-l4jjb93l	132	24	suggest	suggest	VBP
cord-334907-l4jjb93l	132	25	their	-PRON-	PRP$
cord-334907-l4jjb93l	132	26	participation	participation	NN
cord-334907-l4jjb93l	132	27	in	in	IN
cord-334907-l4jjb93l	132	28	a	a	DT
cord-334907-l4jjb93l	132	29	receptor	receptor	NN
cord-334907-l4jjb93l	132	30	-	-	HYPH
cord-334907-l4jjb93l	132	31	binding	bind	VBG
cord-334907-l4jjb93l	132	32	site	site	NN
cord-334907-l4jjb93l	132	33	,	,	,
cord-334907-l4jjb93l	132	34	with	with	IN
cord-334907-l4jjb93l	132	35	direct	direct	JJ
cord-334907-l4jjb93l	132	36	participation	participation	NN
cord-334907-l4jjb93l	132	37	of	of	IN
cord-334907-l4jjb93l	132	38	these	these	DT
cord-334907-l4jjb93l	132	39	two	two	CD
cord-334907-l4jjb93l	132	40	amino	amino	NN
cord-334907-l4jjb93l	132	41	acids	acid	NNS
cord-334907-l4jjb93l	132	42	.	.	.
cord-334907-l4jjb93l	133	1	Table	table	NN
cord-334907-l4jjb93l	133	2	1	1	CD
cord-334907-l4jjb93l	133	3	.	.	.
cord-334907-l4jjb93l	134	1	Heterologous	heterologous	JJ
cord-334907-l4jjb93l	134	2	expression	expression	NN
cord-334907-l4jjb93l	134	3	constructs	construct	NNS
cord-334907-l4jjb93l	134	4	developed	develop	VBN
cord-334907-l4jjb93l	134	5	to	to	TO
cord-334907-l4jjb93l	134	6	evaluate	evaluate	VB
cord-334907-l4jjb93l	134	7	the	the	DT
cord-334907-l4jjb93l	134	8	fusion	fusion	NN
cord-334907-l4jjb93l	134	9	mechanism	mechanism	NN
cord-334907-l4jjb93l	134	10	of	of	IN
cord-334907-l4jjb93l	134	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	134	12	.	.	.
cord-334907-l4jjb93l	135	1	The	the	DT
cord-334907-l4jjb93l	135	2	combination	combination	NN
cord-334907-l4jjb93l	135	3	of	of	IN
cord-334907-l4jjb93l	135	4	HE	HE	NNP
cord-334907-l4jjb93l	135	5	and	and	CC
cord-334907-l4jjb93l	135	6	F	F	NNP
cord-334907-l4jjb93l	135	7	from	from	IN
cord-334907-l4jjb93l	135	8	an	an	DT
cord-334907-l4jjb93l	135	9	HPR3	HPR3	NNP
cord-334907-l4jjb93l	135	10	strain	strain	NN
cord-334907-l4jjb93l	135	11	(	(	-LRB-
cord-334907-l4jjb93l	135	12	HE3	HE3	NNP
cord-334907-l4jjb93l	135	13	and	and	CC
cord-334907-l4jjb93l	135	14	F3	F3	NNP
cord-334907-l4jjb93l	135	15	,	,	,
cord-334907-l4jjb93l	135	16	respectively	respectively	RB
cord-334907-l4jjb93l	135	17	)	)	-RRB-
cord-334907-l4jjb93l	135	18	was	be	VBD
cord-334907-l4jjb93l	135	19	used	use	VBN
cord-334907-l4jjb93l	135	20	as	as	IN
cord-334907-l4jjb93l	135	21	positive	positive	JJ
cord-334907-l4jjb93l	135	22	control	control	NN
cord-334907-l4jjb93l	135	23	.	.	.
cord-334907-l4jjb93l	136	1	A	a	DT
cord-334907-l4jjb93l	136	2	combination	combination	NN
cord-334907-l4jjb93l	136	3	of	of	IN
cord-334907-l4jjb93l	136	4	HE	HE	NNP
cord-334907-l4jjb93l	136	5	from	from	IN
cord-334907-l4jjb93l	136	6	HPR0	HPR0	NNP
cord-334907-l4jjb93l	136	7	(	(	-LRB-
cord-334907-l4jjb93l	136	8	HE0	HE0	NNP
cord-334907-l4jjb93l	136	9	)	)	-RRB-
cord-334907-l4jjb93l	136	10	and	and	CC
cord-334907-l4jjb93l	136	11	F3	F3	NNP
cord-334907-l4jjb93l	136	12	was	be	VBD
cord-334907-l4jjb93l	136	13	used	use	VBN
cord-334907-l4jjb93l	136	14	to	to	TO
cord-334907-l4jjb93l	136	15	evaluate	evaluate	VB
cord-334907-l4jjb93l	136	16	the	the	DT
cord-334907-l4jjb93l	136	17	influence	influence	NN
cord-334907-l4jjb93l	136	18	of	of	IN
cord-334907-l4jjb93l	136	19	the	the	DT
cord-334907-l4jjb93l	136	20	stalk	stalk	NN
cord-334907-l4jjb93l	136	21	length	length	NN
cord-334907-l4jjb93l	136	22	on	on	IN
cord-334907-l4jjb93l	136	23	the	the	DT
cord-334907-l4jjb93l	136	24	system	system	NN
cord-334907-l4jjb93l	136	25	.	.	.
cord-334907-l4jjb93l	137	1	Mutants	mutant	NNS
cord-334907-l4jjb93l	137	2	were	be	VBD
cord-334907-l4jjb93l	137	3	designed	design	VBN
cord-334907-l4jjb93l	137	4	to	to	TO
cord-334907-l4jjb93l	137	5	determine	determine	VB
cord-334907-l4jjb93l	137	6	the	the	DT
cord-334907-l4jjb93l	137	7	influence	influence	NN
cord-334907-l4jjb93l	137	8	of	of	IN
cord-334907-l4jjb93l	137	9	the	the	DT
cord-334907-l4jjb93l	137	10	F	F	NNP
cord-334907-l4jjb93l	137	11	1	1	CD
cord-334907-l4jjb93l	137	12	domain	domain	NN
cord-334907-l4jjb93l	137	13	in	in	IN
cord-334907-l4jjb93l	137	14	F	F	NNP
cord-334907-l4jjb93l	137	15	,	,	,
cord-334907-l4jjb93l	137	16	and	and	CC
cord-334907-l4jjb93l	137	17	the	the	DT
cord-334907-l4jjb93l	137	18	esterase	esterase	NN
cord-334907-l4jjb93l	137	19	activity	activity	NN
cord-334907-l4jjb93l	137	20	,	,	,
cord-334907-l4jjb93l	137	21	accordingly	accordingly	RB
cord-334907-l4jjb93l	137	22	.	.	.
cord-334907-l4jjb93l	138	1	All	all	DT
cord-334907-l4jjb93l	138	2	wild	wild	JJ
cord-334907-l4jjb93l	138	3	type	type	NN
cord-334907-l4jjb93l	138	4	(	(	-LRB-
cord-334907-l4jjb93l	138	5	WT	WT	NNP
cord-334907-l4jjb93l	138	6	)	)	-RRB-
cord-334907-l4jjb93l	138	7	and	and	CC
cord-334907-l4jjb93l	138	8	mutant	mutant	JJ
cord-334907-l4jjb93l	138	9	open	open	JJ
cord-334907-l4jjb93l	138	10	reading	reading	NN
cord-334907-l4jjb93l	138	11	frames	frame	NNS
cord-334907-l4jjb93l	138	12	(	(	-LRB-
cord-334907-l4jjb93l	138	13	ORFs	ORFs	NNP
cord-334907-l4jjb93l	138	14	)	)	-RRB-
cord-334907-l4jjb93l	138	15	were	be	VBD
cord-334907-l4jjb93l	138	16	cloned	clone	VBN
cord-334907-l4jjb93l	138	17	in	in	IN
cord-334907-l4jjb93l	138	18	the	the	DT
cord-334907-l4jjb93l	138	19	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	138	20	-	-	HYPH
cord-334907-l4jjb93l	138	21	CMV14	CMV14	NNP
cord-334907-l4jjb93l	138	22	expression	expression	NN
cord-334907-l4jjb93l	138	23	vector	vector	NN
cord-334907-l4jjb93l	138	24	.	.	.
cord-334907-l4jjb93l	139	1	All	all	DT
cord-334907-l4jjb93l	139	2	constructs	construct	NNS
cord-334907-l4jjb93l	139	3	were	be	VBD
cord-334907-l4jjb93l	139	4	3xFLAG	3xflag	RB
cord-334907-l4jjb93l	139	5	-	-	HYPH
cord-334907-l4jjb93l	139	6	tagged	tag	VBN
cord-334907-l4jjb93l	139	7	at	at	IN
cord-334907-l4jjb93l	139	8	the	the	DT
cord-334907-l4jjb93l	139	9	carboxy	carboxy	JJ
cord-334907-l4jjb93l	139	10	-	-	HYPH
cord-334907-l4jjb93l	139	11	terminal	terminal	NN
cord-334907-l4jjb93l	139	12	end	end	NN
cord-334907-l4jjb93l	139	13	.	.	.
cord-334907-l4jjb93l	140	1	Fluorescent	fluorescent	JJ
cord-334907-l4jjb93l	140	2	fusion	fusion	NN
cord-334907-l4jjb93l	140	3	proteins	protein	NNS
cord-334907-l4jjb93l	140	4	were	be	VBD
cord-334907-l4jjb93l	140	5	developed	develop	VBN
cord-334907-l4jjb93l	140	6	for	for	IN
cord-334907-l4jjb93l	140	7	each	each	DT
cord-334907-l4jjb93l	140	8	construct	construct	NN
cord-334907-l4jjb93l	140	9	,	,	,
cord-334907-l4jjb93l	140	10	adding	add	VBG
cord-334907-l4jjb93l	140	11	eGFP	egfp	JJ
cord-334907-l4jjb93l	140	12	or	or	CC
cord-334907-l4jjb93l	140	13	mCherry	mCherry	NNP
cord-334907-l4jjb93l	140	14	to	to	IN
cord-334907-l4jjb93l	140	15	the	the	DT
cord-334907-l4jjb93l	140	16	carboxy	carboxy	JJ
cord-334907-l4jjb93l	140	17	-	-	HYPH
cord-334907-l4jjb93l	140	18	terminal	terminal	NN
cord-334907-l4jjb93l	140	19	end	end	NN
cord-334907-l4jjb93l	140	20	of	of	IN
cord-334907-l4jjb93l	140	21	the	the	DT
cord-334907-l4jjb93l	140	22	HEs	HEs	NNPS
cord-334907-l4jjb93l	140	23	and	and	CC
cord-334907-l4jjb93l	140	24	Fs	Fs	NNPS
cord-334907-l4jjb93l	140	25	,	,	,
cord-334907-l4jjb93l	140	26	respectively	respectively	RB
cord-334907-l4jjb93l	140	27	(	(	-LRB-
cord-334907-l4jjb93l	140	28	not	not	RB
cord-334907-l4jjb93l	140	29	shown	show	VBN
cord-334907-l4jjb93l	140	30	in	in	IN
cord-334907-l4jjb93l	140	31	table	table	NN
cord-334907-l4jjb93l	140	32	)	)	-RRB-
cord-334907-l4jjb93l	140	33	.	.	.
cord-334907-l4jjb93l	141	1	Considering	consider	VBG
cord-334907-l4jjb93l	141	2	our	-PRON-	PRP$
cord-334907-l4jjb93l	141	3	results	result	NNS
cord-334907-l4jjb93l	141	4	,	,	,
cord-334907-l4jjb93l	141	5	we	-PRON-	PRP
cord-334907-l4jjb93l	141	6	hypothesized	hypothesize	VBD
cord-334907-l4jjb93l	141	7	that	that	IN
cord-334907-l4jjb93l	141	8	the	the	DT
cord-334907-l4jjb93l	141	9	esterase	esterase	NN
cord-334907-l4jjb93l	141	10	in	in	IN
cord-334907-l4jjb93l	141	11	HE	he	PRP
cord-334907-l4jjb93l	141	12	has	have	VBZ
cord-334907-l4jjb93l	141	13	the	the	DT
cord-334907-l4jjb93l	141	14	capacity	capacity	NN
cord-334907-l4jjb93l	141	15	to	to	TO
cord-334907-l4jjb93l	141	16	hydrolyze	hydrolyze	VB
cord-334907-l4jjb93l	141	17	the	the	DT
cord-334907-l4jjb93l	141	18	receptor	receptor	NN
cord-334907-l4jjb93l	141	19	for	for	IN
cord-334907-l4jjb93l	141	20	F	F	NNP
cord-334907-l4jjb93l	141	21	1	1	CD
cord-334907-l4jjb93l	141	22	and	and	CC
cord-334907-l4jjb93l	141	23	that	that	IN
cord-334907-l4jjb93l	141	24	this	this	DT
cord-334907-l4jjb93l	141	25	interaction	interaction	NN
cord-334907-l4jjb93l	141	26	is	be	VBZ
cord-334907-l4jjb93l	141	27	crucial	crucial	JJ
cord-334907-l4jjb93l	141	28	for	for	IN
cord-334907-l4jjb93l	141	29	the	the	DT
cord-334907-l4jjb93l	141	30	fusion	fusion	NN
cord-334907-l4jjb93l	141	31	activity	activity	NN
cord-334907-l4jjb93l	141	32	of	of	IN
cord-334907-l4jjb93l	141	33	F.	F.	NNP
cord-334907-l4jjb93l	141	34	To	to	TO
cord-334907-l4jjb93l	141	35	analyze	analyze	VB
cord-334907-l4jjb93l	141	36	the	the	DT
cord-334907-l4jjb93l	141	37	influence	influence	NN
cord-334907-l4jjb93l	141	38	of	of	IN
cord-334907-l4jjb93l	141	39	the	the	DT
cord-334907-l4jjb93l	141	40	HE	HE	NNP
cord-334907-l4jjb93l	141	41	HPR0	HPR0	NNP
cord-334907-l4jjb93l	141	42	esterase	esterase	NN
cord-334907-l4jjb93l	141	43	activity	activity	NN
cord-334907-l4jjb93l	141	44	over	over	IN
cord-334907-l4jjb93l	141	45	the	the	DT
cord-334907-l4jjb93l	141	46	fusion	fusion	NN
cord-334907-l4jjb93l	141	47	mechanism	mechanism	NN
cord-334907-l4jjb93l	141	48	,	,	,
cord-334907-l4jjb93l	141	49	an	an	DT
cord-334907-l4jjb93l	141	50	HE	HE	NNP
cord-334907-l4jjb93l	141	51	Ser32Ala	Ser32Ala	NNS
cord-334907-l4jjb93l	141	52	mutant	mutant	JJ
cord-334907-l4jjb93l	141	53	was	be	VBD
cord-334907-l4jjb93l	141	54	developed	develop	VBN
cord-334907-l4jjb93l	141	55	,	,	,
cord-334907-l4jjb93l	141	56	rendering	render	VBG
cord-334907-l4jjb93l	141	57	the	the	DT
cord-334907-l4jjb93l	141	58	enzyme	enzyme	NN
cord-334907-l4jjb93l	141	59	inactive	inactive	JJ
cord-334907-l4jjb93l	141	60	[	[	-LRB-
cord-334907-l4jjb93l	141	61	10	10	CD
cord-334907-l4jjb93l	141	62	]	]	-RRB-
cord-334907-l4jjb93l	141	63	.	.	.
cord-334907-l4jjb93l	142	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	142	2	,	,	,
cord-334907-l4jjb93l	142	3	the	the	DT
cord-334907-l4jjb93l	142	4	fusion	fusion	NN
cord-334907-l4jjb93l	142	5	mechanism	mechanism	NN
cord-334907-l4jjb93l	142	6	with	with	IN
cord-334907-l4jjb93l	142	7	the	the	DT
cord-334907-l4jjb93l	142	8	HE0∆EST	HE0∆EST	NNP
cord-334907-l4jjb93l	142	9	/	/	SYM
cord-334907-l4jjb93l	142	10	F3	F3	NNP
cord-334907-l4jjb93l	142	11	combination	combination	NN
cord-334907-l4jjb93l	142	12	showed	show	VBD
cord-334907-l4jjb93l	142	13	a	a	DT
cord-334907-l4jjb93l	142	14	level	level	NN
cord-334907-l4jjb93l	142	15	of	of	IN
cord-334907-l4jjb93l	142	16	40	40	CD
cord-334907-l4jjb93l	142	17	%	%	NN
cord-334907-l4jjb93l	142	18	of	of	IN
cord-334907-l4jjb93l	142	19	fusion	fusion	NN
cord-334907-l4jjb93l	142	20	activity	activity	NN
cord-334907-l4jjb93l	142	21	,	,	,
cord-334907-l4jjb93l	142	22	10	10	CD
cord-334907-l4jjb93l	142	23	times	time	NNS
cord-334907-l4jjb93l	142	24	the	the	DT
cord-334907-l4jjb93l	142	25	activity	activity	NN
cord-334907-l4jjb93l	142	26	displayed	display	VBN
cord-334907-l4jjb93l	142	27	by	by	IN
cord-334907-l4jjb93l	142	28	the	the	DT
cord-334907-l4jjb93l	142	29	HE0	HE0	NNP
cord-334907-l4jjb93l	142	30	/	/	SYM
cord-334907-l4jjb93l	142	31	F3	F3	NNP
cord-334907-l4jjb93l	142	32	system	system	NN
cord-334907-l4jjb93l	142	33	,	,	,
cord-334907-l4jjb93l	142	34	implying	imply	VBG
cord-334907-l4jjb93l	142	35	a	a	DT
cord-334907-l4jjb93l	142	36	negative	negative	JJ
cord-334907-l4jjb93l	142	37	influence	influence	NN
cord-334907-l4jjb93l	142	38	of	of	IN
cord-334907-l4jjb93l	142	39	the	the	DT
cord-334907-l4jjb93l	142	40	enzyme	enzyme	NN
cord-334907-l4jjb93l	142	41	over	over	IN
cord-334907-l4jjb93l	142	42	the	the	DT
cord-334907-l4jjb93l	142	43	viral	viral	JJ
cord-334907-l4jjb93l	142	44	fusion	fusion	NN
cord-334907-l4jjb93l	142	45	mechanism	mechanism	NN
cord-334907-l4jjb93l	142	46	(	(	-LRB-
cord-334907-l4jjb93l	142	47	Figure	figure	NN
cord-334907-l4jjb93l	142	48	5c	5c	CD
cord-334907-l4jjb93l	142	49	)	)	-RRB-
cord-334907-l4jjb93l	142	50	.	.	.
cord-334907-l4jjb93l	143	1	This	this	DT
cord-334907-l4jjb93l	143	2	result	result	NN
cord-334907-l4jjb93l	143	3	coincides	coincide	VBZ
cord-334907-l4jjb93l	143	4	with	with	IN
cord-334907-l4jjb93l	143	5	our	-PRON-	PRP$
cord-334907-l4jjb93l	143	6	hypothesis	hypothesis	NN
cord-334907-l4jjb93l	143	7	,	,	,
cord-334907-l4jjb93l	143	8	suggesting	suggest	VBG
cord-334907-l4jjb93l	143	9	that	that	IN
cord-334907-l4jjb93l	143	10	the	the	DT
cord-334907-l4jjb93l	143	11	esterase	esterase	NN
cord-334907-l4jjb93l	143	12	in	in	IN
cord-334907-l4jjb93l	143	13	HE	he	PRP
cord-334907-l4jjb93l	143	14	has	have	VBZ
cord-334907-l4jjb93l	143	15	activity	activity	NN
cord-334907-l4jjb93l	143	16	against	against	IN
cord-334907-l4jjb93l	143	17	the	the	DT
cord-334907-l4jjb93l	143	18	F	F	NNP
cord-334907-l4jjb93l	143	19	receptor	receptor	NN
cord-334907-l4jjb93l	143	20	and	and	CC
cord-334907-l4jjb93l	143	21	that	that	IN
cord-334907-l4jjb93l	143	22	this	this	DT
cord-334907-l4jjb93l	143	23	activity	activity	NN
cord-334907-l4jjb93l	143	24	has	have	VBZ
cord-334907-l4jjb93l	143	25	a	a	DT
cord-334907-l4jjb93l	143	26	detrimental	detrimental	JJ
cord-334907-l4jjb93l	143	27	effect	effect	NN
cord-334907-l4jjb93l	143	28	over	over	IN
cord-334907-l4jjb93l	143	29	the	the	DT
cord-334907-l4jjb93l	143	30	membrane	membrane	NN
cord-334907-l4jjb93l	143	31	fusion	fusion	NN
cord-334907-l4jjb93l	143	32	mechanism	mechanism	NN
cord-334907-l4jjb93l	143	33	.	.	.
cord-334907-l4jjb93l	144	1	Moreover	moreover	RB
cord-334907-l4jjb93l	144	2	,	,	,
cord-334907-l4jjb93l	144	3	this	this	DT
cord-334907-l4jjb93l	144	4	result	result	NN
cord-334907-l4jjb93l	144	5	led	lead	VBD
cord-334907-l4jjb93l	144	6	us	-PRON-	PRP
cord-334907-l4jjb93l	144	7	to	to	IN
cord-334907-l4jjb93l	144	8	the	the	DT
cord-334907-l4jjb93l	144	9	hypothesis	hypothesis	NN
cord-334907-l4jjb93l	144	10	that	that	IN
cord-334907-l4jjb93l	144	11	the	the	DT
cord-334907-l4jjb93l	144	12	diminished	diminished	JJ
cord-334907-l4jjb93l	144	13	fusion	fusion	NN
cord-334907-l4jjb93l	144	14	activity	activity	NN
cord-334907-l4jjb93l	144	15	associated	associate	VBN
cord-334907-l4jjb93l	144	16	with	with	IN
cord-334907-l4jjb93l	144	17	the	the	DT
cord-334907-l4jjb93l	144	18	HE	HE	NNP
cord-334907-l4jjb93l	144	19	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	144	20	may	may	MD
cord-334907-l4jjb93l	144	21	be	be	VB
cord-334907-l4jjb93l	144	22	connected	connect	VBN
cord-334907-l4jjb93l	144	23	to	to	IN
cord-334907-l4jjb93l	144	24	the	the	DT
cord-334907-l4jjb93l	144	25	esterase	esterase	NN
cord-334907-l4jjb93l	144	26	activity	activity	NN
cord-334907-l4jjb93l	144	27	of	of	IN
cord-334907-l4jjb93l	144	28	this	this	DT
cord-334907-l4jjb93l	144	29	protein	protein	NN
cord-334907-l4jjb93l	144	30	.	.	.
cord-334907-l4jjb93l	145	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	145	2	2020	2020	CD
cord-334907-l4jjb93l	145	3	,	,	,
cord-334907-l4jjb93l	145	4	9	9	CD
cord-334907-l4jjb93l	145	5	,	,	,
cord-334907-l4jjb93l	145	6	x	x	NN
cord-334907-l4jjb93l	145	7	FOR	for	IN
cord-334907-l4jjb93l	145	8	PEER	PEER	NNP
cord-334907-l4jjb93l	145	9	REVIEW	REVIEW	NNP
cord-334907-l4jjb93l	145	10	7	7	CD
cord-334907-l4jjb93l	145	11	of	of	IN
cord-334907-l4jjb93l	145	12	18	18	CD
cord-334907-l4jjb93l	145	13	mechanism	mechanism	NN
cord-334907-l4jjb93l	145	14	.	.	.
cord-334907-l4jjb93l	146	1	Moreover	moreover	RB
cord-334907-l4jjb93l	146	2	,	,	,
cord-334907-l4jjb93l	146	3	this	this	DT
cord-334907-l4jjb93l	146	4	result	result	NN
cord-334907-l4jjb93l	146	5	led	lead	VBD
cord-334907-l4jjb93l	146	6	us	-PRON-	PRP
cord-334907-l4jjb93l	146	7	to	to	IN
cord-334907-l4jjb93l	146	8	the	the	DT
cord-334907-l4jjb93l	146	9	hypothesis	hypothesis	NN
cord-334907-l4jjb93l	146	10	that	that	IN
cord-334907-l4jjb93l	146	11	the	the	DT
cord-334907-l4jjb93l	146	12	diminished	diminished	JJ
cord-334907-l4jjb93l	146	13	fusion	fusion	NN
cord-334907-l4jjb93l	146	14	activity	activity	NN
cord-334907-l4jjb93l	146	15	associated	associate	VBN
cord-334907-l4jjb93l	146	16	with	with	IN
cord-334907-l4jjb93l	146	17	the	the	DT
cord-334907-l4jjb93l	146	18	HE	HE	NNP
cord-334907-l4jjb93l	146	19	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	146	20	may	may	MD
cord-334907-l4jjb93l	146	21	be	be	VB
cord-334907-l4jjb93l	146	22	connected	connect	VBN
cord-334907-l4jjb93l	146	23	to	to	IN
cord-334907-l4jjb93l	146	24	the	the	DT
cord-334907-l4jjb93l	146	25	esterase	esterase	NN
cord-334907-l4jjb93l	146	26	activity	activity	NN
cord-334907-l4jjb93l	146	27	of	of	IN
cord-334907-l4jjb93l	146	28	this	this	DT
cord-334907-l4jjb93l	146	29	protein	protein	NN
cord-334907-l4jjb93l	146	30	.	.	.
cord-334907-l4jjb93l	147	1	Esterase	esterase	NN
cord-334907-l4jjb93l	147	2	inactivation	inactivation	NN
cord-334907-l4jjb93l	147	3	via	via	IN
cord-334907-l4jjb93l	147	4	Ser32Ala	Ser32Ala	NNS
cord-334907-l4jjb93l	147	5	mutation	mutation	NN
cord-334907-l4jjb93l	147	6	on	on	IN
cord-334907-l4jjb93l	147	7	HE0	HE0	NNP
cord-334907-l4jjb93l	147	8	significantly	significantly	RB
cord-334907-l4jjb93l	147	9	augments	augment	VBZ
cord-334907-l4jjb93l	147	10	the	the	DT
cord-334907-l4jjb93l	147	11	native	native	JJ
cord-334907-l4jjb93l	147	12	fusion	fusion	NN
cord-334907-l4jjb93l	147	13	activity	activity	NN
cord-334907-l4jjb93l	147	14	of	of	IN
cord-334907-l4jjb93l	147	15	the	the	DT
cord-334907-l4jjb93l	147	16	HPR0	HPR0	NNP
cord-334907-l4jjb93l	147	17	system	system	NN
cord-334907-l4jjb93l	147	18	,	,	,
cord-334907-l4jjb93l	147	19	from	from	IN
cord-334907-l4jjb93l	147	20	4	4	CD
cord-334907-l4jjb93l	147	21	%	%	NN
cord-334907-l4jjb93l	147	22	to	to	IN
cord-334907-l4jjb93l	147	23	40	40	CD
cord-334907-l4jjb93l	147	24	%	%	NN
cord-334907-l4jjb93l	147	25	.	.	.
cord-334907-l4jjb93l	148	1	Asterisks	asterisks	UH
cord-334907-l4jjb93l	148	2	*	*	NFP
cord-334907-l4jjb93l	148	3	,	,	,
cord-334907-l4jjb93l	148	4	*	*	NFP
cord-334907-l4jjb93l	148	5	*	*	NFP
cord-334907-l4jjb93l	148	6	,	,	,
cord-334907-l4jjb93l	148	7	and	and	CC
cord-334907-l4jjb93l	149	1	*	*	NFP
cord-334907-l4jjb93l	149	2	*	*	NFP
cord-334907-l4jjb93l	149	3	*	*	NFP
cord-334907-l4jjb93l	149	4	indicate	indicate	VBP
cord-334907-l4jjb93l	149	5	statistical	statistical	JJ
cord-334907-l4jjb93l	149	6	significance	significance	NN
cord-334907-l4jjb93l	149	7	with	with	IN
cord-334907-l4jjb93l	149	8	p	p	NN
cord-334907-l4jjb93l	149	9	<	<	XX
cord-334907-l4jjb93l	149	10	0.05	0.05	CD
cord-334907-l4jjb93l	149	11	,	,	,
cord-334907-l4jjb93l	149	12	p	p	NN
cord-334907-l4jjb93l	149	13	<	<	XX
cord-334907-l4jjb93l	149	14	0.01	0.01	CD
cord-334907-l4jjb93l	149	15	,	,	,
cord-334907-l4jjb93l	149	16	and	and	CC
cord-334907-l4jjb93l	149	17	p	p	NN
cord-334907-l4jjb93l	149	18	<	<	XX
cord-334907-l4jjb93l	149	19	0.001	0.001	CD
cord-334907-l4jjb93l	149	20	,	,	,
cord-334907-l4jjb93l	149	21	respectively	respectively	RB
cord-334907-l4jjb93l	149	22	.	.	.
cord-334907-l4jjb93l	150	1	The	the	DT
cord-334907-l4jjb93l	150	2	present	present	JJ
cord-334907-l4jjb93l	150	3	study	study	NN
cord-334907-l4jjb93l	150	4	demonstrated	demonstrate	VBD
cord-334907-l4jjb93l	150	5	a	a	DT
cord-334907-l4jjb93l	150	6	crucial	crucial	JJ
cord-334907-l4jjb93l	150	7	role	role	NN
cord-334907-l4jjb93l	150	8	for	for	IN
cord-334907-l4jjb93l	150	9	the	the	DT
cord-334907-l4jjb93l	150	10	F1	F1	NNP
cord-334907-l4jjb93l	150	11	domain	domain	NN
cord-334907-l4jjb93l	150	12	of	of	IN
cord-334907-l4jjb93l	150	13	the	the	DT
cord-334907-l4jjb93l	150	14	ISAV	ISAV	NNP
cord-334907-l4jjb93l	150	15	F	F	NNP
cord-334907-l4jjb93l	150	16	protein	protein	NN
cord-334907-l4jjb93l	150	17	in	in	IN
cord-334907-l4jjb93l	150	18	membrane	membrane	NN
cord-334907-l4jjb93l	150	19	fusion	fusion	NN
cord-334907-l4jjb93l	150	20	,	,	,
cord-334907-l4jjb93l	150	21	a	a	DT
cord-334907-l4jjb93l	150	22	key	key	JJ
cord-334907-l4jjb93l	150	23	step	step	NN
cord-334907-l4jjb93l	150	24	in	in	IN
cord-334907-l4jjb93l	150	25	the	the	DT
cord-334907-l4jjb93l	150	26	viral	viral	JJ
cord-334907-l4jjb93l	150	27	infection	infection	NN
cord-334907-l4jjb93l	150	28	process	process	NN
cord-334907-l4jjb93l	150	29	.	.	.
cord-334907-l4jjb93l	151	1	F1	F1	NNP
cord-334907-l4jjb93l	151	2	interacts	interact	VBZ
cord-334907-l4jjb93l	151	3	with	with	IN
cord-334907-l4jjb93l	151	4	target	target	NN
cord-334907-l4jjb93l	151	5	cells	cell	NNS
cord-334907-l4jjb93l	151	6	,	,	,
cord-334907-l4jjb93l	151	7	and	and	CC
cord-334907-l4jjb93l	151	8	its	-PRON-	PRP$
cord-334907-l4jjb93l	151	9	putative	putative	JJ
cord-334907-l4jjb93l	151	10	receptor	receptor	NN
cord-334907-l4jjb93l	151	11	may	may	MD
cord-334907-l4jjb93l	151	12	be	be	VB
cord-334907-l4jjb93l	151	13	hydrolyzed	hydrolyze	VBN
cord-334907-l4jjb93l	151	14	by	by	IN
cord-334907-l4jjb93l	151	15	the	the	DT
cord-334907-l4jjb93l	151	16	esterase	esterase	NN
cord-334907-l4jjb93l	151	17	present	present	JJ
cord-334907-l4jjb93l	151	18	in	in	IN
cord-334907-l4jjb93l	151	19	the	the	DT
cord-334907-l4jjb93l	151	20	HE	HE	NNP
cord-334907-l4jjb93l	151	21	viral	viral	JJ
cord-334907-l4jjb93l	151	22	protein	protein	NN
cord-334907-l4jjb93l	151	23	.	.	.
cord-334907-l4jjb93l	152	1	The	the	DT
cord-334907-l4jjb93l	152	2	enzyme	enzyme	NN
cord-334907-l4jjb93l	152	3	has	have	VBZ
cord-334907-l4jjb93l	152	4	influence	influence	NN
cord-334907-l4jjb93l	152	5	over	over	IN
cord-334907-l4jjb93l	152	6	the	the	DT
cord-334907-l4jjb93l	152	7	fusion	fusion	NN
cord-334907-l4jjb93l	152	8	phenomena	phenomenon	NNS
cord-334907-l4jjb93l	152	9	,	,	,
cord-334907-l4jjb93l	152	10	presumably	presumably	RB
cord-334907-l4jjb93l	152	11	hydrolyzing	hydrolyze	VBG
cord-334907-l4jjb93l	152	12	the	the	DT
cord-334907-l4jjb93l	152	13	F	F	NNP
cord-334907-l4jjb93l	152	14	receptor	receptor	NN
cord-334907-l4jjb93l	152	15	.	.	.
cord-334907-l4jjb93l	153	1	Finally	finally	RB
cord-334907-l4jjb93l	153	2	,	,	,
cord-334907-l4jjb93l	153	3	we	-PRON-	PRP
cord-334907-l4jjb93l	153	4	hypothesize	hypothesize	VBP
cord-334907-l4jjb93l	153	5	that	that	IN
cord-334907-l4jjb93l	153	6	the	the	DT
cord-334907-l4jjb93l	153	7	activity	activity	NN
cord-334907-l4jjb93l	153	8	of	of	IN
cord-334907-l4jjb93l	153	9	the	the	DT
cord-334907-l4jjb93l	153	10	enzyme	enzyme	NN
cord-334907-l4jjb93l	153	11	over	over	IN
cord-334907-l4jjb93l	153	12	the	the	DT
cord-334907-l4jjb93l	153	13	F	F	NNP
cord-334907-l4jjb93l	153	14	cellular	cellular	JJ
cord-334907-l4jjb93l	153	15	ligand	ligand	NN
cord-334907-l4jjb93l	153	16	is	be	VBZ
cord-334907-l4jjb93l	153	17	regulated	regulate	VBN
cord-334907-l4jjb93l	153	18	by	by	IN
cord-334907-l4jjb93l	153	19	the	the	DT
cord-334907-l4jjb93l	153	20	length	length	NN
cord-334907-l4jjb93l	153	21	of	of	IN
cord-334907-l4jjb93l	153	22	the	the	DT
cord-334907-l4jjb93l	153	23	HPR	HPR	NNP
cord-334907-l4jjb93l	153	24	region	region	NN
cord-334907-l4jjb93l	153	25	,	,	,
cord-334907-l4jjb93l	153	26	where	where	WRB
cord-334907-l4jjb93l	153	27	an	an	DT
cord-334907-l4jjb93l	153	28	HE	HE	NNP
cord-334907-l4jjb93l	153	29	with	with	IN
cord-334907-l4jjb93l	153	30	an	an	DT
cord-334907-l4jjb93l	153	31	extended	extended	JJ
cord-334907-l4jjb93l	153	32	region	region	NN
cord-334907-l4jjb93l	153	33	(	(	-LRB-
cord-334907-l4jjb93l	153	34	i.e.	i.e.	FW
cord-334907-l4jjb93l	153	35	,	,	,
cord-334907-l4jjb93l	153	36	HPR0	HPR0	NNP
cord-334907-l4jjb93l	153	37	)	)	-RRB-
cord-334907-l4jjb93l	153	38	could	could	MD
cord-334907-l4jjb93l	153	39	be	be	VB
cord-334907-l4jjb93l	153	40	more	more	RBR
cord-334907-l4jjb93l	153	41	active	active	JJ
cord-334907-l4jjb93l	153	42	against	against	IN
cord-334907-l4jjb93l	153	43	this	this	DT
cord-334907-l4jjb93l	153	44	putative	putative	JJ
cord-334907-l4jjb93l	153	45	sialic	sialic	NN
cord-334907-l4jjb93l	153	46	acid	acid	NN
cord-334907-l4jjb93l	153	47	.	.	.
cord-334907-l4jjb93l	154	1	Hydrolysis	hydrolysis	NN
cord-334907-l4jjb93l	154	2	of	of	IN
cord-334907-l4jjb93l	154	3	the	the	DT
cord-334907-l4jjb93l	154	4	F	F	NNP
cord-334907-l4jjb93l	154	5	receptor	receptor	NN
cord-334907-l4jjb93l	154	6	upon	upon	IN
cord-334907-l4jjb93l	154	7	viral	viral	JJ
cord-334907-l4jjb93l	154	8	adhesion	adhesion	NN
cord-334907-l4jjb93l	154	9	may	may	MD
cord-334907-l4jjb93l	154	10	impede	impede	VB
cord-334907-l4jjb93l	154	11	F1	f1	NN
cord-334907-l4jjb93l	154	12	interaction	interaction	NN
cord-334907-l4jjb93l	154	13	with	with	IN
cord-334907-l4jjb93l	154	14	the	the	DT
cord-334907-l4jjb93l	154	15	cell	cell	NN
cord-334907-l4jjb93l	154	16	,	,	,
cord-334907-l4jjb93l	154	17	diminishing	diminish	VBG
cord-334907-l4jjb93l	154	18	the	the	DT
cord-334907-l4jjb93l	154	19	membrane	membrane	NN
cord-334907-l4jjb93l	154	20	fusion	fusion	NN
cord-334907-l4jjb93l	154	21	process	process	NN
cord-334907-l4jjb93l	154	22	and	and	CC
cord-334907-l4jjb93l	154	23	the	the	DT
cord-334907-l4jjb93l	154	24	subsequent	subsequent	JJ
cord-334907-l4jjb93l	154	25	viral	viral	JJ
cord-334907-l4jjb93l	154	26	infection	infection	NN
cord-334907-l4jjb93l	154	27	.	.	.
cord-334907-l4jjb93l	155	1	These	these	DT
cord-334907-l4jjb93l	155	2	findings	finding	NNS
cord-334907-l4jjb93l	155	3	represent	represent	VBP
cord-334907-l4jjb93l	155	4	new	new	JJ
cord-334907-l4jjb93l	155	5	data	datum	NNS
cord-334907-l4jjb93l	155	6	by	by	IN
cord-334907-l4jjb93l	155	7	which	which	WDT
cord-334907-l4jjb93l	155	8	the	the	DT
cord-334907-l4jjb93l	155	9	functional	functional	JJ
cord-334907-l4jjb93l	155	10	basis	basis	NN
cord-334907-l4jjb93l	155	11	of	of	IN
cord-334907-l4jjb93l	155	12	the	the	DT
cord-334907-l4jjb93l	155	13	ISAV	ISAV	NNP
cord-334907-l4jjb93l	155	14	HPR0	HPR0	NNP
cord-334907-l4jjb93l	155	15	behavior	behavior	NN
cord-334907-l4jjb93l	155	16	and	and	CC
cord-334907-l4jjb93l	155	17	the	the	DT
cord-334907-l4jjb93l	155	18	virus	virus	NN
cord-334907-l4jjb93l	155	19	infection	infection	NN
cord-334907-l4jjb93l	155	20	mechanism	mechanism	NN
cord-334907-l4jjb93l	155	21	may	may	MD
cord-334907-l4jjb93l	155	22	be	be	VB
cord-334907-l4jjb93l	155	23	understood	understand	VBN
cord-334907-l4jjb93l	155	24	.	.	.
cord-334907-l4jjb93l	156	1	Interaction	interaction	NN
cord-334907-l4jjb93l	156	2	with	with	IN
cord-334907-l4jjb93l	156	3	cell	cell	NN
cord-334907-l4jjb93l	156	4	receptors	receptor	NNS
cord-334907-l4jjb93l	156	5	is	be	VBZ
cord-334907-l4jjb93l	156	6	a	a	DT
cord-334907-l4jjb93l	156	7	key	key	JJ
cord-334907-l4jjb93l	156	8	element	element	NN
cord-334907-l4jjb93l	156	9	for	for	IN
cord-334907-l4jjb93l	156	10	the	the	DT
cord-334907-l4jjb93l	156	11	activation	activation	NN
cord-334907-l4jjb93l	156	12	of	of	IN
cord-334907-l4jjb93l	156	13	viral	viral	JJ
cord-334907-l4jjb93l	156	14	infective	infective	JJ
cord-334907-l4jjb93l	156	15	mechanisms	mechanism	NNS
cord-334907-l4jjb93l	156	16	,	,	,
cord-334907-l4jjb93l	156	17	either	either	CC
cord-334907-l4jjb93l	156	18	directly	directly	RB
cord-334907-l4jjb93l	156	19	or	or	CC
cord-334907-l4jjb93l	156	20	by	by	IN
cord-334907-l4jjb93l	156	21	conducting	conduct	VBG
cord-334907-l4jjb93l	156	22	the	the	DT
cord-334907-l4jjb93l	156	23	viral	viral	JJ
cord-334907-l4jjb93l	156	24	particle	particle	NN
cord-334907-l4jjb93l	156	25	to	to	IN
cord-334907-l4jjb93l	156	26	cell	cell	NN
cord-334907-l4jjb93l	156	27	regions	region	NNS
cord-334907-l4jjb93l	156	28	where	where	WRB
cord-334907-l4jjb93l	156	29	these	these	DT
cord-334907-l4jjb93l	156	30	systems	system	NNS
cord-334907-l4jjb93l	156	31	can	can	MD
cord-334907-l4jjb93l	156	32	be	be	VB
cord-334907-l4jjb93l	156	33	activated	activate	VBN
cord-334907-l4jjb93l	156	34	[	[	-LRB-
cord-334907-l4jjb93l	156	35	36	36	CD
cord-334907-l4jjb93l	156	36	,	,	,
cord-334907-l4jjb93l	156	37	37	37	CD
cord-334907-l4jjb93l	156	38	]	]	-RRB-
cord-334907-l4jjb93l	156	39	.	.	.
cord-334907-l4jjb93l	157	1	On	on	IN
cord-334907-l4jjb93l	157	2	the	the	DT
cord-334907-l4jjb93l	157	3	other	other	JJ
cord-334907-l4jjb93l	157	4	hand	hand	NN
cord-334907-l4jjb93l	157	5	,	,	,
cord-334907-l4jjb93l	157	6	receptor	receptor	NN
cord-334907-l4jjb93l	157	7	destruction	destruction	NN
cord-334907-l4jjb93l	157	8	plays	play	VBZ
cord-334907-l4jjb93l	157	9	an	an	DT
cord-334907-l4jjb93l	157	10	important	important	JJ
cord-334907-l4jjb93l	157	11	role	role	NN
cord-334907-l4jjb93l	157	12	in	in	IN
cord-334907-l4jjb93l	157	13	the	the	DT
cord-334907-l4jjb93l	157	14	release	release	NN
cord-334907-l4jjb93l	157	15	of	of	IN
cord-334907-l4jjb93l	157	16	the	the	DT
cord-334907-l4jjb93l	157	17	new	new	JJ
cord-334907-l4jjb93l	157	18	viral	viral	JJ
cord-334907-l4jjb93l	157	19	particles	particle	NNS
cord-334907-l4jjb93l	157	20	.	.	.
cord-334907-l4jjb93l	158	1	Ultimately	ultimately	RB
cord-334907-l4jjb93l	158	2	,	,	,
cord-334907-l4jjb93l	158	3	differential	differential	JJ
cord-334907-l4jjb93l	158	4	expression	expression	NN
cord-334907-l4jjb93l	158	5	of	of	IN
cord-334907-l4jjb93l	158	6	receptors	receptor	NNS
cord-334907-l4jjb93l	158	7	in	in	IN
cord-334907-l4jjb93l	158	8	particular	particular	JJ
cord-334907-l4jjb93l	158	9	cells	cell	NNS
cord-334907-l4jjb93l	158	10	may	may	MD
cord-334907-l4jjb93l	158	11	regulate	regulate	VB
cord-334907-l4jjb93l	158	12	the	the	DT
cord-334907-l4jjb93l	158	13	pathogen	pathogen	NN
cord-334907-l4jjb93l	158	14	's	's	POS
cord-334907-l4jjb93l	158	15	tropism	tropism	NN
cord-334907-l4jjb93l	158	16	[	[	-LRB-
cord-334907-l4jjb93l	158	17	23	23	CD
cord-334907-l4jjb93l	158	18	]	]	-RRB-
cord-334907-l4jjb93l	158	19	.	.	.
cord-334907-l4jjb93l	159	1	In	in	IN
cord-334907-l4jjb93l	159	2	the	the	DT
cord-334907-l4jjb93l	159	3	case	case	NN
cord-334907-l4jjb93l	159	4	of	of	IN
cord-334907-l4jjb93l	159	5	ISAV	ISAV	NNP
cord-334907-l4jjb93l	159	6	,	,	,
cord-334907-l4jjb93l	159	7	adhesion	adhesion	NN
cord-334907-l4jjb93l	159	8	to	to	IN
cord-334907-l4jjb93l	159	9	the	the	DT
cord-334907-l4jjb93l	159	10	target	target	NN
cord-334907-l4jjb93l	159	11	cells	cell	NNS
cord-334907-l4jjb93l	159	12	has	have	VBZ
cord-334907-l4jjb93l	159	13	been	be	VBN
cord-334907-l4jjb93l	159	14	attributed	attribute	VBN
cord-334907-l4jjb93l	159	15	to	to	IN
cord-334907-l4jjb93l	159	16	the	the	DT
cord-334907-l4jjb93l	159	17	viral	viral	JJ
cord-334907-l4jjb93l	159	18	HE	HE	NNP
cord-334907-l4jjb93l	159	19	interaction	interaction	NN
cord-334907-l4jjb93l	159	20	with	with	IN
cord-334907-l4jjb93l	159	21	a	a	DT
cord-334907-l4jjb93l	159	22	sialic	sialic	JJ
cord-334907-l4jjb93l	159	23	acid	acid	NN
cord-334907-l4jjb93l	159	24	(	(	-LRB-
cord-334907-l4jjb93l	159	25	5-N	5-n	CD
cord-334907-l4jjb93l	159	26	,	,	,
cord-334907-l4jjb93l	159	27	4-O	4-o	CD
cord-334907-l4jjb93l	159	28	acetylated	acetylated	JJ
cord-334907-l4jjb93l	159	29	)	)	-RRB-
cord-334907-l4jjb93l	159	30	on	on	IN
cord-334907-l4jjb93l	159	31	the	the	DT
cord-334907-l4jjb93l	159	32	cell	cell	NN
cord-334907-l4jjb93l	159	33	surface	surface	NN
cord-334907-l4jjb93l	159	34	[	[	-LRB-
cord-334907-l4jjb93l	159	35	28	28	CD
cord-334907-l4jjb93l	159	36	]	]	-RRB-
cord-334907-l4jjb93l	159	37	.	.	.
cord-334907-l4jjb93l	160	1	The	the	DT
cord-334907-l4jjb93l	160	2	membrane	membrane	NN
cord-334907-l4jjb93l	160	3	fusion	fusion	NN
cord-334907-l4jjb93l	160	4	activity	activity	NN
cord-334907-l4jjb93l	160	5	,	,	,
cord-334907-l4jjb93l	160	6	on	on	IN
cord-334907-l4jjb93l	160	7	the	the	DT
cord-334907-l4jjb93l	160	8	other	other	JJ
cord-334907-l4jjb93l	160	9	hand	hand	NN
cord-334907-l4jjb93l	160	10	,	,	,
cord-334907-l4jjb93l	160	11	is	be	VBZ
cord-334907-l4jjb93l	160	12	mediated	mediate	VBN
cord-334907-l4jjb93l	160	13	by	by	IN
cord-334907-l4jjb93l	160	14	the	the	DT
cord-334907-l4jjb93l	160	15	so	so	RB
cord-334907-l4jjb93l	160	16	-	-	HYPH
cord-334907-l4jjb93l	160	17	called	call	VBN
cord-334907-l4jjb93l	160	18	fusion	fusion	NN
cord-334907-l4jjb93l	160	19	protein	protein	NN
cord-334907-l4jjb93l	160	20	(	(	-LRB-
cord-334907-l4jjb93l	160	21	F	F	NNP
cord-334907-l4jjb93l	160	22	)	)	-RRB-
cord-334907-l4jjb93l	160	23	,	,	,
cord-334907-l4jjb93l	160	24	eventually	eventually	RB
cord-334907-l4jjb93l	160	25	promoting	promote	VBG
cord-334907-l4jjb93l	160	26	the	the	DT
cord-334907-l4jjb93l	160	27	transference	transference	NN
cord-334907-l4jjb93l	160	28	of	of	IN
cord-334907-l4jjb93l	160	29	the	the	DT
cord-334907-l4jjb93l	160	30	viral	viral	JJ
cord-334907-l4jjb93l	160	31	content	content	NN
cord-334907-l4jjb93l	160	32	into	into	IN
cord-334907-l4jjb93l	160	33	the	the	DT
cord-334907-l4jjb93l	160	34	cell	cell	NN
cord-334907-l4jjb93l	160	35	[	[	-LRB-
cord-334907-l4jjb93l	160	36	12	12	CD
cord-334907-l4jjb93l	160	37	]	]	-RRB-
cord-334907-l4jjb93l	160	38	.	.	.
cord-334907-l4jjb93l	161	1	Finally	finally	RB
cord-334907-l4jjb93l	161	2	,	,	,
cord-334907-l4jjb93l	161	3	the	the	DT
cord-334907-l4jjb93l	161	4	release	release	NN
cord-334907-l4jjb93l	161	5	of	of	IN
cord-334907-l4jjb93l	161	6	the	the	DT
cord-334907-l4jjb93l	161	7	new	new	JJ
cord-334907-l4jjb93l	161	8	virions	virion	NNS
cord-334907-l4jjb93l	161	9	is	be	VBZ
cord-334907-l4jjb93l	161	10	related	relate	VBN
cord-334907-l4jjb93l	161	11	to	to	IN
cord-334907-l4jjb93l	161	12	the	the	DT
cord-334907-l4jjb93l	161	13	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	161	14	activity	activity	NN
cord-334907-l4jjb93l	161	15	of	of	IN
cord-334907-l4jjb93l	161	16	the	the	DT
cord-334907-l4jjb93l	161	17	esterase	esterase	NN
cord-334907-l4jjb93l	161	18	in	in	IN
cord-334907-l4jjb93l	161	19	HE	HE	NNP
cord-334907-l4jjb93l	161	20	,	,	,
cord-334907-l4jjb93l	161	21	which	which	WDT
cord-334907-l4jjb93l	161	22	acquires	acquire	VBZ
cord-334907-l4jjb93l	161	23	the	the	DT
cord-334907-l4jjb93l	161	24	receptor	receptor	NN
cord-334907-l4jjb93l	161	25	-	-	HYPH
cord-334907-l4jjb93l	161	26	destroying	destroy	VBG
cord-334907-l4jjb93l	161	27	enzyme	enzyme	NN
cord-334907-l4jjb93l	161	28	(	(	-LRB-
cord-334907-l4jjb93l	161	29	RDE	RDE	NNP
cord-334907-l4jjb93l	161	30	)	)	-RRB-
cord-334907-l4jjb93l	161	31	quality	quality	NN
cord-334907-l4jjb93l	161	32	[	[	-LRB-
cord-334907-l4jjb93l	161	33	28	28	CD
cord-334907-l4jjb93l	161	34	]	]	-RRB-
cord-334907-l4jjb93l	161	35	.	.	.
cord-334907-l4jjb93l	162	1	In	in	IN
cord-334907-l4jjb93l	162	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	162	3	,	,	,
cord-334907-l4jjb93l	162	4	this	this	DT
cord-334907-l4jjb93l	162	5	simplified	simplified	JJ
cord-334907-l4jjb93l	162	6	scheme	scheme	NN
cord-334907-l4jjb93l	162	7	does	do	VBZ
cord-334907-l4jjb93l	162	8	not	not	RB
cord-334907-l4jjb93l	162	9	cover	cover	VB
cord-334907-l4jjb93l	162	10	the	the	DT
cord-334907-l4jjb93l	162	11	real	real	JJ
cord-334907-l4jjb93l	162	12	complexity	complexity	NN
cord-334907-l4jjb93l	162	13	of	of	IN
cord-334907-l4jjb93l	162	14	the	the	DT
cord-334907-l4jjb93l	162	15	system	system	NN
cord-334907-l4jjb93l	162	16	.	.	.
cord-334907-l4jjb93l	163	1	One	one	CD
cord-334907-l4jjb93l	163	2	of	of	IN
cord-334907-l4jjb93l	163	3	the	the	DT
cord-334907-l4jjb93l	163	4	greatest	great	JJS
cord-334907-l4jjb93l	163	5	questions	question	NNS
cord-334907-l4jjb93l	163	6	surrounding	surround	VBG
cord-334907-l4jjb93l	163	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	163	8	is	be	VBZ
cord-334907-l4jjb93l	163	9	the	the	DT
cord-334907-l4jjb93l	163	10	relation	relation	NN
cord-334907-l4jjb93l	163	11	between	between	IN
cord-334907-l4jjb93l	163	12	the	the	DT
cord-334907-l4jjb93l	163	13	nonvirulent	nonvirulent	JJ
cord-334907-l4jjb93l	163	14	HPR0	HPR0	NNP
cord-334907-l4jjb93l	163	15	strains	strain	NNS
cord-334907-l4jjb93l	163	16	and	and	CC
cord-334907-l4jjb93l	163	17	their	-PRON-	PRP$
cord-334907-l4jjb93l	163	18	virulent	virulent	JJ
cord-334907-l4jjb93l	163	19	counterparts	counterpart	NNS
cord-334907-l4jjb93l	163	20	.	.	.
cord-334907-l4jjb93l	164	1	It	-PRON-	PRP
cord-334907-l4jjb93l	164	2	has	have	VBZ
cord-334907-l4jjb93l	164	3	been	be	VBN
cord-334907-l4jjb93l	164	4	proposed	propose	VBN
cord-334907-l4jjb93l	164	5	that	that	IN
cord-334907-l4jjb93l	164	6	the	the	DT
cord-334907-l4jjb93l	164	7	former	former	JJ
cord-334907-l4jjb93l	164	8	are	be	VBP
cord-334907-l4jjb93l	164	9	the	the	DT
cord-334907-l4jjb93l	164	10	ancestral	ancestral	JJ
cord-334907-l4jjb93l	164	11	strains	strain	NNS
cord-334907-l4jjb93l	164	12	,	,	,
cord-334907-l4jjb93l	164	13	given	give	VBN
cord-334907-l4jjb93l	164	14	that	that	IN
cord-334907-l4jjb93l	164	15	they	-PRON-	PRP
cord-334907-l4jjb93l	164	16	have	have	VBP
cord-334907-l4jjb93l	164	17	the	the	DT
cord-334907-l4jjb93l	164	18	genetic	genetic	JJ
cord-334907-l4jjb93l	164	19	potential	potential	NN
cord-334907-l4jjb93l	164	20	(	(	-LRB-
cord-334907-l4jjb93l	164	21	i.e.	i.e.	FW
cord-334907-l4jjb93l	164	22	,	,	,
cord-334907-l4jjb93l	164	23	full	full	JJ
cord-334907-l4jjb93l	164	24	HE	HE	NNP
cord-334907-l4jjb93l	164	25	gene	gene	NN
cord-334907-l4jjb93l	164	26	)	)	-RRB-
cord-334907-l4jjb93l	164	27	[	[	-LRB-
cord-334907-l4jjb93l	164	28	38	38	CD
cord-334907-l4jjb93l	164	29	]	]	-RRB-
cord-334907-l4jjb93l	164	30	.	.	.
cord-334907-l4jjb93l	165	1	Certainly	certainly	RB
cord-334907-l4jjb93l	165	2	,	,	,
cord-334907-l4jjb93l	165	3	the	the	DT
cord-334907-l4jjb93l	165	4	fact	fact	NN
cord-334907-l4jjb93l	165	5	that	that	IN
cord-334907-l4jjb93l	165	6	HPR0	HPR0	NNP
cord-334907-l4jjb93l	165	7	strains	strain	NNS
cord-334907-l4jjb93l	165	8	have	have	VBP
cord-334907-l4jjb93l	165	9	not	not	RB
cord-334907-l4jjb93l	165	10	been	be	VBN
cord-334907-l4jjb93l	165	11	isolated	isolate	VBN
cord-334907-l4jjb93l	165	12	in	in	IN
cord-334907-l4jjb93l	165	13	culture	culture	NN
cord-334907-l4jjb93l	165	14	has	have	VBZ
cord-334907-l4jjb93l	165	15	made	make	VBN
cord-334907-l4jjb93l	165	16	the	the	DT
cord-334907-l4jjb93l	165	17	study	study	NN
cord-334907-l4jjb93l	165	18	of	of	IN
cord-334907-l4jjb93l	165	19	this	this	DT
cord-334907-l4jjb93l	165	20	potential	potential	JJ
cord-334907-l4jjb93l	165	21	relation	relation	NN
cord-334907-l4jjb93l	165	22	very	very	RB
cord-334907-l4jjb93l	165	23	difficult	difficult	JJ
cord-334907-l4jjb93l	165	24	.	.	.
cord-334907-l4jjb93l	166	1	The	the	DT
cord-334907-l4jjb93l	166	2	particular	particular	JJ
cord-334907-l4jjb93l	166	3	mechanisms	mechanism	NNS
cord-334907-l4jjb93l	166	4	involved	involve	VBN
cord-334907-l4jjb93l	166	5	in	in	IN
cord-334907-l4jjb93l	166	6	the	the	DT
cord-334907-l4jjb93l	166	7	lack	lack	NN
cord-334907-l4jjb93l	166	8	of	of	IN
cord-334907-l4jjb93l	166	9	virulence	virulence	NN
cord-334907-l4jjb93l	166	10	and	and	CC
cord-334907-l4jjb93l	166	11	the	the	DT
cord-334907-l4jjb93l	166	12	impossibility	impossibility	NN
cord-334907-l4jjb93l	166	13	of	of	IN
cord-334907-l4jjb93l	166	14	in	in	FW
cord-334907-l4jjb93l	166	15	vitro	vitro	FW
cord-334907-l4jjb93l	166	16	isolation	isolation	NN
cord-334907-l4jjb93l	166	17	have	have	VBP
cord-334907-l4jjb93l	166	18	not	not	RB
cord-334907-l4jjb93l	166	19	been	be	VBN
cord-334907-l4jjb93l	166	20	fully	fully	RB
cord-334907-l4jjb93l	166	21	resolved	resolve	VBN
cord-334907-l4jjb93l	166	22	yet	yet	RB
cord-334907-l4jjb93l	166	23	.	.	.
cord-334907-l4jjb93l	167	1	The	the	DT
cord-334907-l4jjb93l	167	2	molecular	molecular	JJ
cord-334907-l4jjb93l	167	3	characteristic	characteristic	NN
cord-334907-l4jjb93l	167	4	that	that	WDT
cord-334907-l4jjb93l	167	5	defines	define	VBZ
cord-334907-l4jjb93l	167	6	the	the	DT
cord-334907-l4jjb93l	167	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	167	8	HPR0	HPR0	NNP
cord-334907-l4jjb93l	167	9	strains	strain	NNS
cord-334907-l4jjb93l	167	10	is	be	VBZ
cord-334907-l4jjb93l	167	11	the	the	DT
cord-334907-l4jjb93l	167	12	presence	presence	NN
cord-334907-l4jjb93l	167	13	of	of	IN
cord-334907-l4jjb93l	167	14	an	an	DT
cord-334907-l4jjb93l	167	15	elongated	elongated	JJ
cord-334907-l4jjb93l	167	16	version	version	NN
cord-334907-l4jjb93l	167	17	of	of	IN
cord-334907-l4jjb93l	167	18	the	the	DT
cord-334907-l4jjb93l	167	19	HE	HE	NNP
cord-334907-l4jjb93l	167	20	gene	gene	NN
cord-334907-l4jjb93l	167	21	,	,	,
cord-334907-l4jjb93l	167	22	compared	compare	VBN
cord-334907-l4jjb93l	167	23	to	to	IN
cord-334907-l4jjb93l	167	24	the	the	DT
cord-334907-l4jjb93l	167	25	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	167	26	types	type	NNS
cord-334907-l4jjb93l	167	27	.	.	.
cord-334907-l4jjb93l	168	1	Both	both	DT
cord-334907-l4jjb93l	168	2	HPR0	HPR0	NNP
cord-334907-l4jjb93l	168	3	and	and	CC
cord-334907-l4jjb93l	168	4	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	168	5	HEs	he	NNS
cord-334907-l4jjb93l	168	6	are	be	VBP
cord-334907-l4jjb93l	168	7	fully	fully	RB
cord-334907-l4jjb93l	168	8	functional	functional	JJ
cord-334907-l4jjb93l	168	9	in	in	IN
cord-334907-l4jjb93l	168	10	terms	term	NNS
cord-334907-l4jjb93l	168	11	of	of	IN
cord-334907-l4jjb93l	168	12	their	-PRON-	PRP$
cord-334907-l4jjb93l	168	13	receptor	receptor	NN
cord-334907-l4jjb93l	168	14	-	-	HYPH
cord-334907-l4jjb93l	168	15	binding	bind	VBG
cord-334907-l4jjb93l	168	16	activities	activity	NNS
cord-334907-l4jjb93l	168	17	,	,	,
cord-334907-l4jjb93l	168	18	as	as	IN
cord-334907-l4jjb93l	168	19	proved	prove	VBN
cord-334907-l4jjb93l	168	20	by	by	IN
cord-334907-l4jjb93l	168	21	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	168	22	assays	assay	NNS
cord-334907-l4jjb93l	168	23	using	use	VBG
cord-334907-l4jjb93l	168	24	salmon	salmon	NNP
cord-334907-l4jjb93l	168	25	RBC	RBC	NNP
cord-334907-l4jjb93l	168	26	.	.	.
cord-334907-l4jjb93l	169	1	(	(	-LRB-
cord-334907-l4jjb93l	169	2	c	c	NN
cord-334907-l4jjb93l	169	3	)	)	-RRB-
cord-334907-l4jjb93l	170	1	Esterase	esterase	NN
cord-334907-l4jjb93l	170	2	inactivation	inactivation	NN
cord-334907-l4jjb93l	170	3	via	via	IN
cord-334907-l4jjb93l	170	4	Ser32Ala	Ser32Ala	NNS
cord-334907-l4jjb93l	170	5	mutation	mutation	NN
cord-334907-l4jjb93l	170	6	on	on	IN
cord-334907-l4jjb93l	170	7	HE0	HE0	NNP
cord-334907-l4jjb93l	170	8	significantly	significantly	RB
cord-334907-l4jjb93l	170	9	augments	augment	VBZ
cord-334907-l4jjb93l	170	10	the	the	DT
cord-334907-l4jjb93l	170	11	native	native	JJ
cord-334907-l4jjb93l	170	12	fusion	fusion	NN
cord-334907-l4jjb93l	170	13	activity	activity	NN
cord-334907-l4jjb93l	170	14	of	of	IN
cord-334907-l4jjb93l	170	15	the	the	DT
cord-334907-l4jjb93l	170	16	HPR0	HPR0	NNP
cord-334907-l4jjb93l	170	17	system	system	NN
cord-334907-l4jjb93l	170	18	,	,	,
cord-334907-l4jjb93l	170	19	from	from	IN
cord-334907-l4jjb93l	170	20	4	4	CD
cord-334907-l4jjb93l	170	21	%	%	NN
cord-334907-l4jjb93l	170	22	to	to	IN
cord-334907-l4jjb93l	170	23	40	40	CD
cord-334907-l4jjb93l	170	24	%	%	NN
cord-334907-l4jjb93l	170	25	.	.	.
cord-334907-l4jjb93l	171	1	Asterisks	asterisks	UH
cord-334907-l4jjb93l	171	2	*	*	NFP
cord-334907-l4jjb93l	171	3	,	,	,
cord-334907-l4jjb93l	171	4	*	*	NFP
cord-334907-l4jjb93l	171	5	*	*	NFP
cord-334907-l4jjb93l	171	6	,	,	,
cord-334907-l4jjb93l	171	7	and	and	CC
cord-334907-l4jjb93l	172	1	*	*	NFP
cord-334907-l4jjb93l	172	2	*	*	NFP
cord-334907-l4jjb93l	172	3	*	*	NFP
cord-334907-l4jjb93l	172	4	indicate	indicate	VBP
cord-334907-l4jjb93l	172	5	statistical	statistical	JJ
cord-334907-l4jjb93l	172	6	significance	significance	NN
cord-334907-l4jjb93l	172	7	with	with	IN
cord-334907-l4jjb93l	172	8	p	p	NN
cord-334907-l4jjb93l	172	9	<	<	XX
cord-334907-l4jjb93l	172	10	0.05	0.05	CD
cord-334907-l4jjb93l	172	11	,	,	,
cord-334907-l4jjb93l	172	12	p	p	NN
cord-334907-l4jjb93l	172	13	<	<	XX
cord-334907-l4jjb93l	172	14	0.01	0.01	CD
cord-334907-l4jjb93l	172	15	,	,	,
cord-334907-l4jjb93l	172	16	and	and	CC
cord-334907-l4jjb93l	172	17	p	p	NN
cord-334907-l4jjb93l	172	18	<	<	XX
cord-334907-l4jjb93l	172	19	0.001	0.001	CD
cord-334907-l4jjb93l	172	20	,	,	,
cord-334907-l4jjb93l	172	21	respectively	respectively	RB
cord-334907-l4jjb93l	172	22	.	.	.
cord-334907-l4jjb93l	173	1	The	the	DT
cord-334907-l4jjb93l	173	2	present	present	JJ
cord-334907-l4jjb93l	173	3	study	study	NN
cord-334907-l4jjb93l	173	4	demonstrated	demonstrate	VBD
cord-334907-l4jjb93l	173	5	a	a	DT
cord-334907-l4jjb93l	173	6	crucial	crucial	JJ
cord-334907-l4jjb93l	173	7	role	role	NN
cord-334907-l4jjb93l	173	8	for	for	IN
cord-334907-l4jjb93l	173	9	the	the	DT
cord-334907-l4jjb93l	173	10	F	F	NNP
cord-334907-l4jjb93l	173	11	1	1	CD
cord-334907-l4jjb93l	173	12	domain	domain	NN
cord-334907-l4jjb93l	173	13	of	of	IN
cord-334907-l4jjb93l	173	14	the	the	DT
cord-334907-l4jjb93l	173	15	ISAV	ISAV	NNP
cord-334907-l4jjb93l	173	16	F	F	NNP
cord-334907-l4jjb93l	173	17	protein	protein	NN
cord-334907-l4jjb93l	173	18	in	in	IN
cord-334907-l4jjb93l	173	19	membrane	membrane	NN
cord-334907-l4jjb93l	173	20	fusion	fusion	NN
cord-334907-l4jjb93l	173	21	,	,	,
cord-334907-l4jjb93l	173	22	a	a	DT
cord-334907-l4jjb93l	173	23	key	key	JJ
cord-334907-l4jjb93l	173	24	step	step	NN
cord-334907-l4jjb93l	173	25	in	in	IN
cord-334907-l4jjb93l	173	26	the	the	DT
cord-334907-l4jjb93l	173	27	viral	viral	JJ
cord-334907-l4jjb93l	173	28	infection	infection	NN
cord-334907-l4jjb93l	173	29	process	process	NN
cord-334907-l4jjb93l	173	30	.	.	.
cord-334907-l4jjb93l	174	1	F	F	NNP
cord-334907-l4jjb93l	174	2	1	1	CD
cord-334907-l4jjb93l	174	3	interacts	interact	VBZ
cord-334907-l4jjb93l	174	4	with	with	IN
cord-334907-l4jjb93l	174	5	target	target	NN
cord-334907-l4jjb93l	174	6	cells	cell	NNS
cord-334907-l4jjb93l	174	7	,	,	,
cord-334907-l4jjb93l	174	8	and	and	CC
cord-334907-l4jjb93l	174	9	its	-PRON-	PRP$
cord-334907-l4jjb93l	174	10	putative	putative	JJ
cord-334907-l4jjb93l	174	11	receptor	receptor	NN
cord-334907-l4jjb93l	174	12	may	may	MD
cord-334907-l4jjb93l	174	13	be	be	VB
cord-334907-l4jjb93l	174	14	hydrolyzed	hydrolyze	VBN
cord-334907-l4jjb93l	174	15	by	by	IN
cord-334907-l4jjb93l	174	16	the	the	DT
cord-334907-l4jjb93l	174	17	esterase	esterase	NN
cord-334907-l4jjb93l	174	18	present	present	JJ
cord-334907-l4jjb93l	174	19	in	in	IN
cord-334907-l4jjb93l	174	20	the	the	DT
cord-334907-l4jjb93l	174	21	HE	HE	NNP
cord-334907-l4jjb93l	174	22	viral	viral	JJ
cord-334907-l4jjb93l	174	23	protein	protein	NN
cord-334907-l4jjb93l	174	24	.	.	.
cord-334907-l4jjb93l	175	1	The	the	DT
cord-334907-l4jjb93l	175	2	enzyme	enzyme	NN
cord-334907-l4jjb93l	175	3	has	have	VBZ
cord-334907-l4jjb93l	175	4	influence	influence	NN
cord-334907-l4jjb93l	175	5	over	over	IN
cord-334907-l4jjb93l	175	6	the	the	DT
cord-334907-l4jjb93l	175	7	fusion	fusion	NN
cord-334907-l4jjb93l	175	8	phenomena	phenomenon	NNS
cord-334907-l4jjb93l	175	9	,	,	,
cord-334907-l4jjb93l	175	10	presumably	presumably	RB
cord-334907-l4jjb93l	175	11	hydrolyzing	hydrolyze	VBG
cord-334907-l4jjb93l	175	12	the	the	DT
cord-334907-l4jjb93l	175	13	F	F	NNP
cord-334907-l4jjb93l	175	14	receptor	receptor	NN
cord-334907-l4jjb93l	175	15	.	.	.
cord-334907-l4jjb93l	176	1	Finally	finally	RB
cord-334907-l4jjb93l	176	2	,	,	,
cord-334907-l4jjb93l	176	3	we	-PRON-	PRP
cord-334907-l4jjb93l	176	4	hypothesize	hypothesize	VBP
cord-334907-l4jjb93l	176	5	that	that	IN
cord-334907-l4jjb93l	176	6	the	the	DT
cord-334907-l4jjb93l	176	7	activity	activity	NN
cord-334907-l4jjb93l	176	8	of	of	IN
cord-334907-l4jjb93l	176	9	the	the	DT
cord-334907-l4jjb93l	176	10	enzyme	enzyme	NN
cord-334907-l4jjb93l	176	11	over	over	IN
cord-334907-l4jjb93l	176	12	the	the	DT
cord-334907-l4jjb93l	176	13	F	F	NNP
cord-334907-l4jjb93l	176	14	cellular	cellular	JJ
cord-334907-l4jjb93l	176	15	ligand	ligand	NN
cord-334907-l4jjb93l	176	16	is	be	VBZ
cord-334907-l4jjb93l	176	17	regulated	regulate	VBN
cord-334907-l4jjb93l	176	18	by	by	IN
cord-334907-l4jjb93l	176	19	the	the	DT
cord-334907-l4jjb93l	176	20	length	length	NN
cord-334907-l4jjb93l	176	21	of	of	IN
cord-334907-l4jjb93l	176	22	the	the	DT
cord-334907-l4jjb93l	176	23	HPR	HPR	NNP
cord-334907-l4jjb93l	176	24	region	region	NN
cord-334907-l4jjb93l	176	25	,	,	,
cord-334907-l4jjb93l	176	26	where	where	WRB
cord-334907-l4jjb93l	176	27	an	an	DT
cord-334907-l4jjb93l	176	28	HE	HE	NNP
cord-334907-l4jjb93l	176	29	with	with	IN
cord-334907-l4jjb93l	176	30	an	an	DT
cord-334907-l4jjb93l	176	31	extended	extended	JJ
cord-334907-l4jjb93l	176	32	region	region	NN
cord-334907-l4jjb93l	176	33	(	(	-LRB-
cord-334907-l4jjb93l	176	34	i.e.	i.e.	FW
cord-334907-l4jjb93l	176	35	,	,	,
cord-334907-l4jjb93l	176	36	HPR0	HPR0	NNP
cord-334907-l4jjb93l	176	37	)	)	-RRB-
cord-334907-l4jjb93l	176	38	could	could	MD
cord-334907-l4jjb93l	176	39	be	be	VB
cord-334907-l4jjb93l	176	40	more	more	RBR
cord-334907-l4jjb93l	176	41	active	active	JJ
cord-334907-l4jjb93l	176	42	against	against	IN
cord-334907-l4jjb93l	176	43	this	this	DT
cord-334907-l4jjb93l	176	44	putative	putative	JJ
cord-334907-l4jjb93l	176	45	sialic	sialic	NN
cord-334907-l4jjb93l	176	46	acid	acid	NN
cord-334907-l4jjb93l	176	47	.	.	.
cord-334907-l4jjb93l	177	1	Hydrolysis	hydrolysis	NN
cord-334907-l4jjb93l	177	2	of	of	IN
cord-334907-l4jjb93l	177	3	the	the	DT
cord-334907-l4jjb93l	177	4	F	F	NNP
cord-334907-l4jjb93l	177	5	receptor	receptor	NN
cord-334907-l4jjb93l	177	6	upon	upon	IN
cord-334907-l4jjb93l	177	7	viral	viral	JJ
cord-334907-l4jjb93l	177	8	adhesion	adhesion	NN
cord-334907-l4jjb93l	177	9	may	may	MD
cord-334907-l4jjb93l	177	10	impede	impede	VB
cord-334907-l4jjb93l	177	11	F	F	NNP
cord-334907-l4jjb93l	177	12	1	1	CD
cord-334907-l4jjb93l	177	13	interaction	interaction	NN
cord-334907-l4jjb93l	177	14	with	with	IN
cord-334907-l4jjb93l	177	15	the	the	DT
cord-334907-l4jjb93l	177	16	cell	cell	NN
cord-334907-l4jjb93l	177	17	,	,	,
cord-334907-l4jjb93l	177	18	diminishing	diminish	VBG
cord-334907-l4jjb93l	177	19	the	the	DT
cord-334907-l4jjb93l	177	20	membrane	membrane	NN
cord-334907-l4jjb93l	177	21	fusion	fusion	NN
cord-334907-l4jjb93l	177	22	process	process	NN
cord-334907-l4jjb93l	177	23	and	and	CC
cord-334907-l4jjb93l	177	24	the	the	DT
cord-334907-l4jjb93l	177	25	subsequent	subsequent	JJ
cord-334907-l4jjb93l	177	26	viral	viral	JJ
cord-334907-l4jjb93l	177	27	infection	infection	NN
cord-334907-l4jjb93l	177	28	.	.	.
cord-334907-l4jjb93l	178	1	These	these	DT
cord-334907-l4jjb93l	178	2	findings	finding	NNS
cord-334907-l4jjb93l	178	3	represent	represent	VBP
cord-334907-l4jjb93l	178	4	new	new	JJ
cord-334907-l4jjb93l	178	5	data	datum	NNS
cord-334907-l4jjb93l	178	6	by	by	IN
cord-334907-l4jjb93l	178	7	which	which	WDT
cord-334907-l4jjb93l	178	8	the	the	DT
cord-334907-l4jjb93l	178	9	functional	functional	JJ
cord-334907-l4jjb93l	178	10	basis	basis	NN
cord-334907-l4jjb93l	178	11	of	of	IN
cord-334907-l4jjb93l	178	12	the	the	DT
cord-334907-l4jjb93l	178	13	ISAV	ISAV	NNP
cord-334907-l4jjb93l	178	14	HPR0	HPR0	NNP
cord-334907-l4jjb93l	178	15	behavior	behavior	NN
cord-334907-l4jjb93l	178	16	and	and	CC
cord-334907-l4jjb93l	178	17	the	the	DT
cord-334907-l4jjb93l	178	18	virus	virus	NN
cord-334907-l4jjb93l	178	19	infection	infection	NN
cord-334907-l4jjb93l	178	20	mechanism	mechanism	NN
cord-334907-l4jjb93l	178	21	may	may	MD
cord-334907-l4jjb93l	178	22	be	be	VB
cord-334907-l4jjb93l	178	23	understood	understand	VBN
cord-334907-l4jjb93l	178	24	.	.	.
cord-334907-l4jjb93l	179	1	Interaction	interaction	NN
cord-334907-l4jjb93l	179	2	with	with	IN
cord-334907-l4jjb93l	179	3	cell	cell	NN
cord-334907-l4jjb93l	179	4	receptors	receptor	NNS
cord-334907-l4jjb93l	179	5	is	be	VBZ
cord-334907-l4jjb93l	179	6	a	a	DT
cord-334907-l4jjb93l	179	7	key	key	JJ
cord-334907-l4jjb93l	179	8	element	element	NN
cord-334907-l4jjb93l	179	9	for	for	IN
cord-334907-l4jjb93l	179	10	the	the	DT
cord-334907-l4jjb93l	179	11	activation	activation	NN
cord-334907-l4jjb93l	179	12	of	of	IN
cord-334907-l4jjb93l	179	13	viral	viral	JJ
cord-334907-l4jjb93l	179	14	infective	infective	JJ
cord-334907-l4jjb93l	179	15	mechanisms	mechanism	NNS
cord-334907-l4jjb93l	179	16	,	,	,
cord-334907-l4jjb93l	179	17	either	either	CC
cord-334907-l4jjb93l	179	18	directly	directly	RB
cord-334907-l4jjb93l	179	19	or	or	CC
cord-334907-l4jjb93l	179	20	by	by	IN
cord-334907-l4jjb93l	179	21	conducting	conduct	VBG
cord-334907-l4jjb93l	179	22	the	the	DT
cord-334907-l4jjb93l	179	23	viral	viral	JJ
cord-334907-l4jjb93l	179	24	particle	particle	NN
cord-334907-l4jjb93l	179	25	to	to	IN
cord-334907-l4jjb93l	179	26	cell	cell	NN
cord-334907-l4jjb93l	179	27	regions	region	NNS
cord-334907-l4jjb93l	179	28	where	where	WRB
cord-334907-l4jjb93l	179	29	these	these	DT
cord-334907-l4jjb93l	179	30	systems	system	NNS
cord-334907-l4jjb93l	179	31	can	can	MD
cord-334907-l4jjb93l	179	32	be	be	VB
cord-334907-l4jjb93l	179	33	activated	activate	VBN
cord-334907-l4jjb93l	179	34	[	[	-LRB-
cord-334907-l4jjb93l	179	35	36	36	CD
cord-334907-l4jjb93l	179	36	,	,	,
cord-334907-l4jjb93l	179	37	37	37	CD
cord-334907-l4jjb93l	179	38	]	]	-RRB-
cord-334907-l4jjb93l	179	39	.	.	.
cord-334907-l4jjb93l	180	1	On	on	IN
cord-334907-l4jjb93l	180	2	the	the	DT
cord-334907-l4jjb93l	180	3	other	other	JJ
cord-334907-l4jjb93l	180	4	hand	hand	NN
cord-334907-l4jjb93l	180	5	,	,	,
cord-334907-l4jjb93l	180	6	receptor	receptor	NN
cord-334907-l4jjb93l	180	7	destruction	destruction	NN
cord-334907-l4jjb93l	180	8	plays	play	VBZ
cord-334907-l4jjb93l	180	9	an	an	DT
cord-334907-l4jjb93l	180	10	important	important	JJ
cord-334907-l4jjb93l	180	11	role	role	NN
cord-334907-l4jjb93l	180	12	in	in	IN
cord-334907-l4jjb93l	180	13	the	the	DT
cord-334907-l4jjb93l	180	14	release	release	NN
cord-334907-l4jjb93l	180	15	of	of	IN
cord-334907-l4jjb93l	180	16	the	the	DT
cord-334907-l4jjb93l	180	17	new	new	JJ
cord-334907-l4jjb93l	180	18	viral	viral	JJ
cord-334907-l4jjb93l	180	19	particles	particle	NNS
cord-334907-l4jjb93l	180	20	.	.	.
cord-334907-l4jjb93l	181	1	Ultimately	ultimately	RB
cord-334907-l4jjb93l	181	2	,	,	,
cord-334907-l4jjb93l	181	3	differential	differential	JJ
cord-334907-l4jjb93l	181	4	expression	expression	NN
cord-334907-l4jjb93l	181	5	of	of	IN
cord-334907-l4jjb93l	181	6	receptors	receptor	NNS
cord-334907-l4jjb93l	181	7	in	in	IN
cord-334907-l4jjb93l	181	8	particular	particular	JJ
cord-334907-l4jjb93l	181	9	cells	cell	NNS
cord-334907-l4jjb93l	181	10	may	may	MD
cord-334907-l4jjb93l	181	11	regulate	regulate	VB
cord-334907-l4jjb93l	181	12	the	the	DT
cord-334907-l4jjb93l	181	13	pathogen	pathogen	NN
cord-334907-l4jjb93l	181	14	's	's	POS
cord-334907-l4jjb93l	181	15	tropism	tropism	NN
cord-334907-l4jjb93l	181	16	[	[	-LRB-
cord-334907-l4jjb93l	181	17	23	23	CD
cord-334907-l4jjb93l	181	18	]	]	-RRB-
cord-334907-l4jjb93l	181	19	.	.	.
cord-334907-l4jjb93l	182	1	In	in	IN
cord-334907-l4jjb93l	182	2	the	the	DT
cord-334907-l4jjb93l	182	3	case	case	NN
cord-334907-l4jjb93l	182	4	of	of	IN
cord-334907-l4jjb93l	182	5	ISAV	ISAV	NNP
cord-334907-l4jjb93l	182	6	,	,	,
cord-334907-l4jjb93l	182	7	adhesion	adhesion	NN
cord-334907-l4jjb93l	182	8	to	to	IN
cord-334907-l4jjb93l	182	9	the	the	DT
cord-334907-l4jjb93l	182	10	target	target	NN
cord-334907-l4jjb93l	182	11	cells	cell	NNS
cord-334907-l4jjb93l	182	12	has	have	VBZ
cord-334907-l4jjb93l	182	13	been	be	VBN
cord-334907-l4jjb93l	182	14	attributed	attribute	VBN
cord-334907-l4jjb93l	182	15	to	to	IN
cord-334907-l4jjb93l	182	16	the	the	DT
cord-334907-l4jjb93l	182	17	viral	viral	JJ
cord-334907-l4jjb93l	182	18	HE	HE	NNP
cord-334907-l4jjb93l	182	19	interaction	interaction	NN
cord-334907-l4jjb93l	182	20	with	with	IN
cord-334907-l4jjb93l	182	21	a	a	DT
cord-334907-l4jjb93l	182	22	sialic	sialic	JJ
cord-334907-l4jjb93l	182	23	acid	acid	NN
cord-334907-l4jjb93l	182	24	(	(	-LRB-
cord-334907-l4jjb93l	182	25	5-N	5-n	CD
cord-334907-l4jjb93l	182	26	,	,	,
cord-334907-l4jjb93l	182	27	4-O	4-o	CD
cord-334907-l4jjb93l	182	28	acetylated	acetylated	JJ
cord-334907-l4jjb93l	182	29	)	)	-RRB-
cord-334907-l4jjb93l	182	30	on	on	IN
cord-334907-l4jjb93l	182	31	the	the	DT
cord-334907-l4jjb93l	182	32	cell	cell	NN
cord-334907-l4jjb93l	182	33	surface	surface	NN
cord-334907-l4jjb93l	182	34	[	[	-LRB-
cord-334907-l4jjb93l	182	35	28	28	CD
cord-334907-l4jjb93l	182	36	]	]	-RRB-
cord-334907-l4jjb93l	182	37	.	.	.
cord-334907-l4jjb93l	183	1	The	the	DT
cord-334907-l4jjb93l	183	2	membrane	membrane	NN
cord-334907-l4jjb93l	183	3	fusion	fusion	NN
cord-334907-l4jjb93l	183	4	activity	activity	NN
cord-334907-l4jjb93l	183	5	,	,	,
cord-334907-l4jjb93l	183	6	on	on	IN
cord-334907-l4jjb93l	183	7	the	the	DT
cord-334907-l4jjb93l	183	8	other	other	JJ
cord-334907-l4jjb93l	183	9	hand	hand	NN
cord-334907-l4jjb93l	183	10	,	,	,
cord-334907-l4jjb93l	183	11	is	be	VBZ
cord-334907-l4jjb93l	183	12	mediated	mediate	VBN
cord-334907-l4jjb93l	183	13	by	by	IN
cord-334907-l4jjb93l	183	14	the	the	DT
cord-334907-l4jjb93l	183	15	so	so	RB
cord-334907-l4jjb93l	183	16	-	-	HYPH
cord-334907-l4jjb93l	183	17	called	call	VBN
cord-334907-l4jjb93l	183	18	fusion	fusion	NN
cord-334907-l4jjb93l	183	19	protein	protein	NN
cord-334907-l4jjb93l	183	20	(	(	-LRB-
cord-334907-l4jjb93l	183	21	F	F	NNP
cord-334907-l4jjb93l	183	22	)	)	-RRB-
cord-334907-l4jjb93l	183	23	,	,	,
cord-334907-l4jjb93l	183	24	eventually	eventually	RB
cord-334907-l4jjb93l	183	25	promoting	promote	VBG
cord-334907-l4jjb93l	183	26	the	the	DT
cord-334907-l4jjb93l	183	27	transference	transference	NN
cord-334907-l4jjb93l	183	28	of	of	IN
cord-334907-l4jjb93l	183	29	the	the	DT
cord-334907-l4jjb93l	183	30	viral	viral	JJ
cord-334907-l4jjb93l	183	31	content	content	NN
cord-334907-l4jjb93l	183	32	into	into	IN
cord-334907-l4jjb93l	183	33	the	the	DT
cord-334907-l4jjb93l	183	34	cell	cell	NN
cord-334907-l4jjb93l	183	35	[	[	-LRB-
cord-334907-l4jjb93l	183	36	12	12	CD
cord-334907-l4jjb93l	183	37	]	]	-RRB-
cord-334907-l4jjb93l	183	38	.	.	.
cord-334907-l4jjb93l	184	1	Finally	finally	RB
cord-334907-l4jjb93l	184	2	,	,	,
cord-334907-l4jjb93l	184	3	the	the	DT
cord-334907-l4jjb93l	184	4	release	release	NN
cord-334907-l4jjb93l	184	5	of	of	IN
cord-334907-l4jjb93l	184	6	the	the	DT
cord-334907-l4jjb93l	184	7	new	new	JJ
cord-334907-l4jjb93l	184	8	virions	virion	NNS
cord-334907-l4jjb93l	184	9	is	be	VBZ
cord-334907-l4jjb93l	184	10	related	relate	VBN
cord-334907-l4jjb93l	184	11	to	to	IN
cord-334907-l4jjb93l	184	12	the	the	DT
cord-334907-l4jjb93l	184	13	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	184	14	activity	activity	NN
cord-334907-l4jjb93l	184	15	of	of	IN
cord-334907-l4jjb93l	184	16	the	the	DT
cord-334907-l4jjb93l	184	17	esterase	esterase	NN
cord-334907-l4jjb93l	184	18	in	in	IN
cord-334907-l4jjb93l	184	19	HE	HE	NNP
cord-334907-l4jjb93l	184	20	,	,	,
cord-334907-l4jjb93l	184	21	which	which	WDT
cord-334907-l4jjb93l	184	22	acquires	acquire	VBZ
cord-334907-l4jjb93l	184	23	the	the	DT
cord-334907-l4jjb93l	184	24	receptor	receptor	NN
cord-334907-l4jjb93l	184	25	-	-	HYPH
cord-334907-l4jjb93l	184	26	destroying	destroy	VBG
cord-334907-l4jjb93l	184	27	enzyme	enzyme	NN
cord-334907-l4jjb93l	184	28	(	(	-LRB-
cord-334907-l4jjb93l	184	29	RDE	RDE	NNP
cord-334907-l4jjb93l	184	30	)	)	-RRB-
cord-334907-l4jjb93l	184	31	quality	quality	NN
cord-334907-l4jjb93l	184	32	[	[	-LRB-
cord-334907-l4jjb93l	184	33	28	28	CD
cord-334907-l4jjb93l	184	34	]	]	-RRB-
cord-334907-l4jjb93l	184	35	.	.	.
cord-334907-l4jjb93l	185	1	In	in	IN
cord-334907-l4jjb93l	185	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	185	3	,	,	,
cord-334907-l4jjb93l	185	4	this	this	DT
cord-334907-l4jjb93l	185	5	simplified	simplified	JJ
cord-334907-l4jjb93l	185	6	scheme	scheme	NN
cord-334907-l4jjb93l	185	7	does	do	VBZ
cord-334907-l4jjb93l	185	8	not	not	RB
cord-334907-l4jjb93l	185	9	cover	cover	VB
cord-334907-l4jjb93l	185	10	the	the	DT
cord-334907-l4jjb93l	185	11	real	real	JJ
cord-334907-l4jjb93l	185	12	complexity	complexity	NN
cord-334907-l4jjb93l	185	13	of	of	IN
cord-334907-l4jjb93l	185	14	the	the	DT
cord-334907-l4jjb93l	185	15	system	system	NN
cord-334907-l4jjb93l	185	16	.	.	.
cord-334907-l4jjb93l	186	1	One	one	CD
cord-334907-l4jjb93l	186	2	of	of	IN
cord-334907-l4jjb93l	186	3	the	the	DT
cord-334907-l4jjb93l	186	4	greatest	great	JJS
cord-334907-l4jjb93l	186	5	questions	question	NNS
cord-334907-l4jjb93l	186	6	surrounding	surround	VBG
cord-334907-l4jjb93l	186	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	186	8	is	be	VBZ
cord-334907-l4jjb93l	186	9	the	the	DT
cord-334907-l4jjb93l	186	10	relation	relation	NN
cord-334907-l4jjb93l	186	11	between	between	IN
cord-334907-l4jjb93l	186	12	the	the	DT
cord-334907-l4jjb93l	186	13	nonvirulent	nonvirulent	JJ
cord-334907-l4jjb93l	186	14	HPR0	HPR0	NNP
cord-334907-l4jjb93l	186	15	strains	strain	NNS
cord-334907-l4jjb93l	186	16	and	and	CC
cord-334907-l4jjb93l	186	17	their	-PRON-	PRP$
cord-334907-l4jjb93l	186	18	virulent	virulent	JJ
cord-334907-l4jjb93l	186	19	counterparts	counterpart	NNS
cord-334907-l4jjb93l	186	20	.	.	.
cord-334907-l4jjb93l	187	1	It	-PRON-	PRP
cord-334907-l4jjb93l	187	2	has	have	VBZ
cord-334907-l4jjb93l	187	3	been	be	VBN
cord-334907-l4jjb93l	187	4	proposed	propose	VBN
cord-334907-l4jjb93l	187	5	that	that	IN
cord-334907-l4jjb93l	187	6	the	the	DT
cord-334907-l4jjb93l	187	7	former	former	JJ
cord-334907-l4jjb93l	187	8	are	be	VBP
cord-334907-l4jjb93l	187	9	the	the	DT
cord-334907-l4jjb93l	187	10	ancestral	ancestral	JJ
cord-334907-l4jjb93l	187	11	strains	strain	NNS
cord-334907-l4jjb93l	187	12	,	,	,
cord-334907-l4jjb93l	187	13	given	give	VBN
cord-334907-l4jjb93l	187	14	that	that	IN
cord-334907-l4jjb93l	187	15	they	-PRON-	PRP
cord-334907-l4jjb93l	187	16	have	have	VBP
cord-334907-l4jjb93l	187	17	the	the	DT
cord-334907-l4jjb93l	187	18	genetic	genetic	JJ
cord-334907-l4jjb93l	187	19	potential	potential	NN
cord-334907-l4jjb93l	187	20	(	(	-LRB-
cord-334907-l4jjb93l	187	21	i.e.	i.e.	FW
cord-334907-l4jjb93l	187	22	,	,	,
cord-334907-l4jjb93l	187	23	full	full	JJ
cord-334907-l4jjb93l	187	24	HE	HE	NNP
cord-334907-l4jjb93l	187	25	gene	gene	NN
cord-334907-l4jjb93l	187	26	)	)	-RRB-
cord-334907-l4jjb93l	187	27	[	[	-LRB-
cord-334907-l4jjb93l	187	28	38	38	CD
cord-334907-l4jjb93l	187	29	]	]	-RRB-
cord-334907-l4jjb93l	187	30	.	.	.
cord-334907-l4jjb93l	188	1	Certainly	certainly	RB
cord-334907-l4jjb93l	188	2	,	,	,
cord-334907-l4jjb93l	188	3	the	the	DT
cord-334907-l4jjb93l	188	4	fact	fact	NN
cord-334907-l4jjb93l	188	5	that	that	IN
cord-334907-l4jjb93l	188	6	HPR0	HPR0	NNP
cord-334907-l4jjb93l	188	7	strains	strain	NNS
cord-334907-l4jjb93l	188	8	have	have	VBP
cord-334907-l4jjb93l	188	9	not	not	RB
cord-334907-l4jjb93l	188	10	been	be	VBN
cord-334907-l4jjb93l	188	11	isolated	isolate	VBN
cord-334907-l4jjb93l	188	12	in	in	IN
cord-334907-l4jjb93l	188	13	culture	culture	NN
cord-334907-l4jjb93l	188	14	has	have	VBZ
cord-334907-l4jjb93l	188	15	made	make	VBN
cord-334907-l4jjb93l	188	16	the	the	DT
cord-334907-l4jjb93l	188	17	study	study	NN
cord-334907-l4jjb93l	188	18	of	of	IN
cord-334907-l4jjb93l	188	19	this	this	DT
cord-334907-l4jjb93l	188	20	potential	potential	JJ
cord-334907-l4jjb93l	188	21	relation	relation	NN
cord-334907-l4jjb93l	188	22	very	very	RB
cord-334907-l4jjb93l	188	23	difficult	difficult	JJ
cord-334907-l4jjb93l	188	24	.	.	.
cord-334907-l4jjb93l	189	1	The	the	DT
cord-334907-l4jjb93l	189	2	particular	particular	JJ
cord-334907-l4jjb93l	189	3	mechanisms	mechanism	NNS
cord-334907-l4jjb93l	189	4	involved	involve	VBN
cord-334907-l4jjb93l	189	5	in	in	IN
cord-334907-l4jjb93l	189	6	the	the	DT
cord-334907-l4jjb93l	189	7	lack	lack	NN
cord-334907-l4jjb93l	189	8	of	of	IN
cord-334907-l4jjb93l	189	9	virulence	virulence	NN
cord-334907-l4jjb93l	189	10	and	and	CC
cord-334907-l4jjb93l	189	11	the	the	DT
cord-334907-l4jjb93l	189	12	impossibility	impossibility	NN
cord-334907-l4jjb93l	189	13	of	of	IN
cord-334907-l4jjb93l	189	14	in	in	FW
cord-334907-l4jjb93l	189	15	vitro	vitro	FW
cord-334907-l4jjb93l	189	16	isolation	isolation	NN
cord-334907-l4jjb93l	189	17	have	have	VBP
cord-334907-l4jjb93l	189	18	not	not	RB
cord-334907-l4jjb93l	189	19	been	be	VBN
cord-334907-l4jjb93l	189	20	fully	fully	RB
cord-334907-l4jjb93l	189	21	resolved	resolve	VBN
cord-334907-l4jjb93l	189	22	yet	yet	RB
cord-334907-l4jjb93l	189	23	.	.	.
cord-334907-l4jjb93l	190	1	The	the	DT
cord-334907-l4jjb93l	190	2	molecular	molecular	JJ
cord-334907-l4jjb93l	190	3	characteristic	characteristic	NN
cord-334907-l4jjb93l	190	4	that	that	WDT
cord-334907-l4jjb93l	190	5	defines	define	VBZ
cord-334907-l4jjb93l	190	6	the	the	DT
cord-334907-l4jjb93l	190	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	190	8	HPR0	HPR0	NNP
cord-334907-l4jjb93l	190	9	strains	strain	NNS
cord-334907-l4jjb93l	190	10	is	be	VBZ
cord-334907-l4jjb93l	190	11	the	the	DT
cord-334907-l4jjb93l	190	12	presence	presence	NN
cord-334907-l4jjb93l	190	13	of	of	IN
cord-334907-l4jjb93l	190	14	an	an	DT
cord-334907-l4jjb93l	190	15	elongated	elongated	JJ
cord-334907-l4jjb93l	190	16	version	version	NN
cord-334907-l4jjb93l	190	17	of	of	IN
cord-334907-l4jjb93l	190	18	the	the	DT
cord-334907-l4jjb93l	190	19	HE	HE	NNP
cord-334907-l4jjb93l	190	20	gene	gene	NN
cord-334907-l4jjb93l	190	21	,	,	,
cord-334907-l4jjb93l	190	22	compared	compare	VBN
cord-334907-l4jjb93l	190	23	to	to	IN
cord-334907-l4jjb93l	190	24	the	the	DT
cord-334907-l4jjb93l	190	25	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	190	26	types	type	NNS
cord-334907-l4jjb93l	190	27	.	.	.
cord-334907-l4jjb93l	191	1	Both	both	DT
cord-334907-l4jjb93l	191	2	HPR0	HPR0	NNP
cord-334907-l4jjb93l	191	3	and	and	CC
cord-334907-l4jjb93l	191	4	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	191	5	HEs	he	NNS
cord-334907-l4jjb93l	191	6	are	be	VBP
cord-334907-l4jjb93l	191	7	fully	fully	RB
cord-334907-l4jjb93l	191	8	functional	functional	JJ
cord-334907-l4jjb93l	191	9	in	in	IN
cord-334907-l4jjb93l	191	10	terms	term	NNS
cord-334907-l4jjb93l	191	11	of	of	IN
cord-334907-l4jjb93l	191	12	their	-PRON-	PRP$
cord-334907-l4jjb93l	191	13	receptor	receptor	NN
cord-334907-l4jjb93l	191	14	-	-	HYPH
cord-334907-l4jjb93l	191	15	binding	bind	VBG
cord-334907-l4jjb93l	191	16	activities	activity	NNS
cord-334907-l4jjb93l	191	17	,	,	,
cord-334907-l4jjb93l	191	18	as	as	IN
cord-334907-l4jjb93l	191	19	proved	prove	VBN
cord-334907-l4jjb93l	191	20	by	by	IN
cord-334907-l4jjb93l	191	21	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	191	22	assays	assay	NNS
cord-334907-l4jjb93l	191	23	using	use	VBG
cord-334907-l4jjb93l	191	24	salmon	salmon	NNP
cord-334907-l4jjb93l	191	25	RBC	RBC	NNP
cord-334907-l4jjb93l	191	26	.	.	.
cord-334907-l4jjb93l	192	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	192	2	,	,	,
cord-334907-l4jjb93l	192	3	when	when	WRB
cord-334907-l4jjb93l	192	4	the	the	DT
cord-334907-l4jjb93l	192	5	assay	assay	NN
cord-334907-l4jjb93l	192	6	was	be	VBD
cord-334907-l4jjb93l	192	7	performed	perform	VBN
cord-334907-l4jjb93l	192	8	using	use	VBG
cord-334907-l4jjb93l	192	9	rabbit	rabbit	NN
cord-334907-l4jjb93l	192	10	RBCs	rbc	NNS
cord-334907-l4jjb93l	192	11	,	,	,
cord-334907-l4jjb93l	192	12	the	the	DT
cord-334907-l4jjb93l	192	13	esterase	esterase	NN
cord-334907-l4jjb93l	192	14	activity	activity	NN
cord-334907-l4jjb93l	192	15	seemed	seem	VBD
cord-334907-l4jjb93l	192	16	to	to	TO
cord-334907-l4jjb93l	192	17	be	be	VB
cord-334907-l4jjb93l	192	18	more	more	RBR
cord-334907-l4jjb93l	192	19	pronounced	pronounced	JJ
cord-334907-l4jjb93l	192	20	in	in	IN
cord-334907-l4jjb93l	192	21	the	the	DT
cord-334907-l4jjb93l	192	22	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	192	23	,	,	,
cord-334907-l4jjb93l	192	24	as	as	IN
cord-334907-l4jjb93l	192	25	manifested	manifest	VBN
cord-334907-l4jjb93l	192	26	in	in	IN
cord-334907-l4jjb93l	192	27	the	the	DT
cord-334907-l4jjb93l	192	28	earlier	early	JJR
cord-334907-l4jjb93l	192	29	release	release	NN
cord-334907-l4jjb93l	192	30	of	of	IN
cord-334907-l4jjb93l	192	31	this	this	DT
cord-334907-l4jjb93l	192	32	type	type	NN
cord-334907-l4jjb93l	192	33	of	of	IN
cord-334907-l4jjb93l	192	34	erythrocyte	erythrocyte	NN
cord-334907-l4jjb93l	192	35	,	,	,
cord-334907-l4jjb93l	192	36	as	as	IN
cord-334907-l4jjb93l	192	37	compared	compare	VBN
cord-334907-l4jjb93l	192	38	to	to	IN
cord-334907-l4jjb93l	192	39	a	a	DT
cord-334907-l4jjb93l	192	40	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	192	41	type	type	NN
cord-334907-l4jjb93l	192	42	[	[	-LRB-
cord-334907-l4jjb93l	192	43	18	18	CD
cord-334907-l4jjb93l	192	44	]	]	-RRB-
cord-334907-l4jjb93l	192	45	.	.	.
cord-334907-l4jjb93l	193	1	This	this	DT
cord-334907-l4jjb93l	193	2	suggests	suggest	VBZ
cord-334907-l4jjb93l	193	3	that	that	IN
cord-334907-l4jjb93l	193	4	the	the	DT
cord-334907-l4jjb93l	193	5	activity	activity	NN
cord-334907-l4jjb93l	193	6	of	of	IN
cord-334907-l4jjb93l	193	7	the	the	DT
cord-334907-l4jjb93l	193	8	enzyme	enzyme	NN
cord-334907-l4jjb93l	193	9	over	over	IN
cord-334907-l4jjb93l	193	10	the	the	DT
cord-334907-l4jjb93l	193	11	receptor	receptor	NN
cord-334907-l4jjb93l	193	12	Pathogens	Pathogens	NNPS
cord-334907-l4jjb93l	193	13	2020	2020	CD
cord-334907-l4jjb93l	193	14	,	,	,
cord-334907-l4jjb93l	193	15	9	9	CD
cord-334907-l4jjb93l	193	16	,	,	,
cord-334907-l4jjb93l	193	17	416	416	CD
cord-334907-l4jjb93l	193	18	8	8	CD
cord-334907-l4jjb93l	193	19	of	of	IN
cord-334907-l4jjb93l	193	20	18	18	CD
cord-334907-l4jjb93l	193	21	present	present	JJ
cord-334907-l4jjb93l	193	22	in	in	IN
cord-334907-l4jjb93l	193	23	the	the	DT
cord-334907-l4jjb93l	193	24	rabbit	rabbit	NN
cord-334907-l4jjb93l	193	25	RBCs	rbc	NNS
cord-334907-l4jjb93l	193	26	may	may	MD
cord-334907-l4jjb93l	193	27	be	be	VB
cord-334907-l4jjb93l	193	28	regulated	regulate	VBN
cord-334907-l4jjb93l	193	29	by	by	IN
cord-334907-l4jjb93l	193	30	the	the	DT
cord-334907-l4jjb93l	193	31	length	length	NN
cord-334907-l4jjb93l	193	32	of	of	IN
cord-334907-l4jjb93l	193	33	the	the	DT
cord-334907-l4jjb93l	193	34	HPR	HPR	NNP
cord-334907-l4jjb93l	193	35	and	and	CC
cord-334907-l4jjb93l	193	36	that	that	IN
cord-334907-l4jjb93l	193	37	this	this	DT
cord-334907-l4jjb93l	193	38	ligand	ligand	NN
cord-334907-l4jjb93l	193	39	for	for	IN
cord-334907-l4jjb93l	193	40	HE	he	PRP
cord-334907-l4jjb93l	193	41	is	be	VBZ
cord-334907-l4jjb93l	193	42	different	different	JJ
cord-334907-l4jjb93l	193	43	from	from	IN
cord-334907-l4jjb93l	193	44	the	the	DT
cord-334907-l4jjb93l	193	45	one	one	NN
cord-334907-l4jjb93l	193	46	located	locate	VBN
cord-334907-l4jjb93l	193	47	on	on	IN
cord-334907-l4jjb93l	193	48	salmon	salmon	NN
cord-334907-l4jjb93l	193	49	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	193	50	.	.	.
cord-334907-l4jjb93l	194	1	On	on	IN
cord-334907-l4jjb93l	194	2	the	the	DT
cord-334907-l4jjb93l	194	3	other	other	JJ
cord-334907-l4jjb93l	194	4	hand	hand	NN
cord-334907-l4jjb93l	194	5	,	,	,
cord-334907-l4jjb93l	194	6	the	the	DT
cord-334907-l4jjb93l	194	7	fact	fact	NN
cord-334907-l4jjb93l	194	8	that	that	IN
cord-334907-l4jjb93l	194	9	salmon	salmon	NN
cord-334907-l4jjb93l	194	10	RBCs	rbc	NNS
cord-334907-l4jjb93l	194	11	are	be	VBP
cord-334907-l4jjb93l	194	12	not	not	RB
cord-334907-l4jjb93l	194	13	released	release	VBN
cord-334907-l4jjb93l	194	14	in	in	IN
cord-334907-l4jjb93l	194	15	the	the	DT
cord-334907-l4jjb93l	194	16	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	194	17	assays	assay	NNS
cord-334907-l4jjb93l	194	18	suggests	suggest	VBZ
cord-334907-l4jjb93l	194	19	that	that	IN
cord-334907-l4jjb93l	194	20	the	the	DT
cord-334907-l4jjb93l	194	21	HPR	HPR	NNP
cord-334907-l4jjb93l	194	22	-	-	HYPH
cord-334907-l4jjb93l	194	23	esterase	esterase	NN
cord-334907-l4jjb93l	194	24	regulation	regulation	NN
cord-334907-l4jjb93l	194	25	may	may	MD
cord-334907-l4jjb93l	194	26	not	not	RB
cord-334907-l4jjb93l	194	27	apply	apply	VB
cord-334907-l4jjb93l	194	28	to	to	IN
cord-334907-l4jjb93l	194	29	the	the	DT
cord-334907-l4jjb93l	194	30	activity	activity	NN
cord-334907-l4jjb93l	194	31	over	over	IN
cord-334907-l4jjb93l	194	32	the	the	DT
cord-334907-l4jjb93l	194	33	"	"	``
cord-334907-l4jjb93l	194	34	primary	primary	JJ
cord-334907-l4jjb93l	194	35	ligand	ligand	NN
cord-334907-l4jjb93l	194	36	"	"	''
cord-334907-l4jjb93l	194	37	(	(	-LRB-
cord-334907-l4jjb93l	194	38	5N-4O	5n-4o	CD
cord-334907-l4jjb93l	194	39	sialic	sialic	JJ
cord-334907-l4jjb93l	194	40	acids	acid	NNS
cord-334907-l4jjb93l	194	41	)	)	-RRB-
cord-334907-l4jjb93l	194	42	described	describe	VBD
cord-334907-l4jjb93l	194	43	as	as	IN
cord-334907-l4jjb93l	194	44	the	the	DT
cord-334907-l4jjb93l	194	45	main	main	JJ
cord-334907-l4jjb93l	194	46	receptor	receptor	NN
cord-334907-l4jjb93l	194	47	for	for	IN
cord-334907-l4jjb93l	194	48	ISAV	ISAV	NNP
cord-334907-l4jjb93l	195	1	HE	he	PRP
cord-334907-l4jjb93l	195	2	.	.	.
cord-334907-l4jjb93l	196	1	This	this	DT
cord-334907-l4jjb93l	196	2	stalk	stalk	NN
cord-334907-l4jjb93l	196	3	-	-	HYPH
cord-334907-l4jjb93l	196	4	length	length	NN
cord-334907-l4jjb93l	196	5	-	-	HYPH
cord-334907-l4jjb93l	196	6	mediated	mediate	VBN
cord-334907-l4jjb93l	196	7	regulation	regulation	NN
cord-334907-l4jjb93l	196	8	of	of	IN
cord-334907-l4jjb93l	196	9	the	the	DT
cord-334907-l4jjb93l	196	10	RDE	RDE	NNP
cord-334907-l4jjb93l	196	11	activity	activity	NN
cord-334907-l4jjb93l	196	12	phenomenon	phenomenon	NN
cord-334907-l4jjb93l	196	13	may	may	MD
cord-334907-l4jjb93l	196	14	have	have	VB
cord-334907-l4jjb93l	196	15	a	a	DT
cord-334907-l4jjb93l	196	16	parallel	parallel	NN
cord-334907-l4jjb93l	196	17	in	in	IN
cord-334907-l4jjb93l	196	18	influenza	influenza	NN
cord-334907-l4jjb93l	196	19	,	,	,
cord-334907-l4jjb93l	196	20	where	where	WRB
cord-334907-l4jjb93l	196	21	the	the	DT
cord-334907-l4jjb93l	196	22	length	length	NN
cord-334907-l4jjb93l	196	23	of	of	IN
cord-334907-l4jjb93l	196	24	the	the	DT
cord-334907-l4jjb93l	196	25	neuraminidase	neuraminidase	NN
cord-334907-l4jjb93l	196	26	stalk	stalk	NN
cord-334907-l4jjb93l	196	27	region	region	NN
cord-334907-l4jjb93l	196	28	seems	seem	VBZ
cord-334907-l4jjb93l	196	29	to	to	TO
cord-334907-l4jjb93l	196	30	be	be	VB
cord-334907-l4jjb93l	196	31	related	relate	VBN
cord-334907-l4jjb93l	196	32	to	to	IN
cord-334907-l4jjb93l	196	33	the	the	DT
cord-334907-l4jjb93l	196	34	viral	viral	JJ
cord-334907-l4jjb93l	196	35	tropism	tropism	NN
cord-334907-l4jjb93l	196	36	in	in	IN
cord-334907-l4jjb93l	196	37	avian	avian	JJ
cord-334907-l4jjb93l	196	38	strains	strain	NNS
cord-334907-l4jjb93l	196	39	[	[	-LRB-
cord-334907-l4jjb93l	196	40	23	23	CD
cord-334907-l4jjb93l	196	41	,	,	,
cord-334907-l4jjb93l	196	42	25	25	CD
cord-334907-l4jjb93l	196	43	]	]	-RRB-
cord-334907-l4jjb93l	196	44	.	.	.
cord-334907-l4jjb93l	197	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	197	2	,	,	,
cord-334907-l4jjb93l	197	3	in	in	IN
cord-334907-l4jjb93l	197	4	ISAV	ISAV	NNP
cord-334907-l4jjb93l	197	5	,	,	,
cord-334907-l4jjb93l	197	6	the	the	DT
cord-334907-l4jjb93l	197	7	fusion	fusion	NN
cord-334907-l4jjb93l	197	8	process	process	NN
cord-334907-l4jjb93l	197	9	is	be	VBZ
cord-334907-l4jjb93l	197	10	affected	affect	VBN
cord-334907-l4jjb93l	197	11	by	by	IN
cord-334907-l4jjb93l	197	12	the	the	DT
cord-334907-l4jjb93l	197	13	length	length	NN
cord-334907-l4jjb93l	197	14	of	of	IN
cord-334907-l4jjb93l	197	15	the	the	DT
cord-334907-l4jjb93l	197	16	HPR	HPR	NNP
cord-334907-l4jjb93l	197	17	in	in	IN
cord-334907-l4jjb93l	197	18	HE	HE	NNP
cord-334907-l4jjb93l	197	19	,	,	,
cord-334907-l4jjb93l	197	20	with	with	IN
cord-334907-l4jjb93l	197	21	a	a	DT
cord-334907-l4jjb93l	197	22	full	full	JJ
cord-334907-l4jjb93l	197	23	stalk	stalk	NN
cord-334907-l4jjb93l	197	24	being	be	VBG
cord-334907-l4jjb93l	197	25	associated	associate	VBN
cord-334907-l4jjb93l	197	26	to	to	IN
cord-334907-l4jjb93l	197	27	a	a	DT
cord-334907-l4jjb93l	197	28	reduced	reduce	VBN
cord-334907-l4jjb93l	197	29	fusion	fusion	NN
cord-334907-l4jjb93l	197	30	activity	activity	NN
cord-334907-l4jjb93l	197	31	[	[	-LRB-
cord-334907-l4jjb93l	197	32	19	19	CD
cord-334907-l4jjb93l	197	33	]	]	-RRB-
cord-334907-l4jjb93l	197	34	.	.	.
cord-334907-l4jjb93l	198	1	Interaction	interaction	NN
cord-334907-l4jjb93l	198	2	of	of	IN
cord-334907-l4jjb93l	198	3	the	the	DT
cord-334907-l4jjb93l	198	4	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	198	5	(	(	-LRB-
cord-334907-l4jjb93l	198	6	HA	HA	NNP
cord-334907-l4jjb93l	198	7	)	)	-RRB-
cord-334907-l4jjb93l	198	8	with	with	IN
cord-334907-l4jjb93l	198	9	its	-PRON-	PRP$
cord-334907-l4jjb93l	198	10	receptor	receptor	NN
cord-334907-l4jjb93l	198	11	in	in	IN
cord-334907-l4jjb93l	198	12	influenza	influenza	NN
cord-334907-l4jjb93l	198	13	virus	virus	NN
cord-334907-l4jjb93l	198	14	is	be	VBZ
cord-334907-l4jjb93l	198	15	a	a	DT
cord-334907-l4jjb93l	198	16	key	key	JJ
cord-334907-l4jjb93l	198	17	step	step	NN
cord-334907-l4jjb93l	198	18	to	to	IN
cord-334907-l4jjb93l	198	19	the	the	DT
cord-334907-l4jjb93l	198	20	activation	activation	NN
cord-334907-l4jjb93l	198	21	of	of	IN
cord-334907-l4jjb93l	198	22	the	the	DT
cord-334907-l4jjb93l	198	23	fusion	fusion	NN
cord-334907-l4jjb93l	198	24	mechanism	mechanism	NN
cord-334907-l4jjb93l	198	25	,	,	,
cord-334907-l4jjb93l	198	26	before	before	IN
cord-334907-l4jjb93l	198	27	the	the	DT
cord-334907-l4jjb93l	198	28	proteolytic	proteolytic	JJ
cord-334907-l4jjb93l	198	29	cleavage	cleavage	NN
cord-334907-l4jjb93l	198	30	and	and	CC
cord-334907-l4jjb93l	198	31	endosomal	endosomal	JJ
cord-334907-l4jjb93l	198	32	acidification	acidification	NN
cord-334907-l4jjb93l	198	33	[	[	-LRB-
cord-334907-l4jjb93l	198	34	26	26	CD
cord-334907-l4jjb93l	198	35	]	]	-RRB-
cord-334907-l4jjb93l	198	36	.	.	.
cord-334907-l4jjb93l	199	1	An	an	DT
cord-334907-l4jjb93l	199	2	analogous	analogous	JJ
cord-334907-l4jjb93l	199	3	condition	condition	NN
cord-334907-l4jjb93l	199	4	is	be	VBZ
cord-334907-l4jjb93l	199	5	true	true	JJ
cord-334907-l4jjb93l	199	6	for	for	IN
cord-334907-l4jjb93l	199	7	paramyxovirus	paramyxovirus	NNP
cord-334907-l4jjb93l	199	8	,	,	,
cord-334907-l4jjb93l	199	9	were	be	VBD
cord-334907-l4jjb93l	200	1	a	a	DT
cord-334907-l4jjb93l	200	2	structural	structural	JJ
cord-334907-l4jjb93l	200	3	change	change	NN
cord-334907-l4jjb93l	200	4	is	be	VBZ
cord-334907-l4jjb93l	200	5	promoted	promote	VBN
cord-334907-l4jjb93l	200	6	by	by	IN
cord-334907-l4jjb93l	200	7	the	the	DT
cord-334907-l4jjb93l	200	8	interaction	interaction	NN
cord-334907-l4jjb93l	200	9	of	of	IN
cord-334907-l4jjb93l	200	10	HN	HN	NNP
cord-334907-l4jjb93l	200	11	with	with	IN
cord-334907-l4jjb93l	200	12	its	-PRON-	PRP$
cord-334907-l4jjb93l	200	13	receptor	receptor	NN
cord-334907-l4jjb93l	200	14	,	,	,
cord-334907-l4jjb93l	200	15	which	which	WDT
cord-334907-l4jjb93l	200	16	in	in	IN
cord-334907-l4jjb93l	200	17	turn	turn	NN
cord-334907-l4jjb93l	200	18	is	be	VBZ
cord-334907-l4jjb93l	200	19	transmitted	transmit	VBN
cord-334907-l4jjb93l	200	20	to	to	IN
cord-334907-l4jjb93l	200	21	the	the	DT
cord-334907-l4jjb93l	200	22	F	F	NNP
cord-334907-l4jjb93l	200	23	protein	protein	NN
cord-334907-l4jjb93l	200	24	,	,	,
cord-334907-l4jjb93l	200	25	triggering	trigger	VBG
cord-334907-l4jjb93l	200	26	a	a	DT
cord-334907-l4jjb93l	200	27	rearrangement	rearrangement	NN
cord-334907-l4jjb93l	200	28	which	which	WDT
cord-334907-l4jjb93l	200	29	ultimately	ultimately	RB
cord-334907-l4jjb93l	200	30	leads	lead	VBZ
cord-334907-l4jjb93l	200	31	to	to	IN
cord-334907-l4jjb93l	200	32	the	the	DT
cord-334907-l4jjb93l	200	33	membranes	membrane	NNS
cord-334907-l4jjb93l	200	34	fusion	fusion	NN
cord-334907-l4jjb93l	200	35	[	[	-LRB-
cord-334907-l4jjb93l	200	36	39	39	CD
cord-334907-l4jjb93l	200	37	]	]	-RRB-
cord-334907-l4jjb93l	200	38	.	.	.
cord-334907-l4jjb93l	201	1	A	a	DT
cord-334907-l4jjb93l	201	2	similar	similar	JJ
cord-334907-l4jjb93l	201	3	model	model	NN
cord-334907-l4jjb93l	201	4	has	have	VBZ
cord-334907-l4jjb93l	201	5	been	be	VBN
cord-334907-l4jjb93l	201	6	proposed	propose	VBN
cord-334907-l4jjb93l	201	7	for	for	IN
cord-334907-l4jjb93l	201	8	ISAV	ISAV	NNP
cord-334907-l4jjb93l	201	9	,	,	,
cord-334907-l4jjb93l	201	10	where	where	WRB
cord-334907-l4jjb93l	201	11	the	the	DT
cord-334907-l4jjb93l	201	12	direct	direct	JJ
cord-334907-l4jjb93l	201	13	interaction	interaction	NN
cord-334907-l4jjb93l	201	14	of	of	IN
cord-334907-l4jjb93l	201	15	HE	HE	NNP
cord-334907-l4jjb93l	201	16	and	and	CC
cord-334907-l4jjb93l	201	17	F	F	NNP
cord-334907-l4jjb93l	201	18	could	could	MD
cord-334907-l4jjb93l	201	19	be	be	VB
cord-334907-l4jjb93l	201	20	responsible	responsible	JJ
cord-334907-l4jjb93l	201	21	for	for	IN
cord-334907-l4jjb93l	201	22	the	the	DT
cord-334907-l4jjb93l	201	23	activation	activation	NN
cord-334907-l4jjb93l	201	24	of	of	IN
cord-334907-l4jjb93l	201	25	the	the	DT
cord-334907-l4jjb93l	201	26	latter	latter	JJ
cord-334907-l4jjb93l	201	27	and	and	CC
cord-334907-l4jjb93l	201	28	the	the	DT
cord-334907-l4jjb93l	201	29	concomitant	concomitant	JJ
cord-334907-l4jjb93l	201	30	dissociation	dissociation	NN
cord-334907-l4jjb93l	201	31	upon	upon	IN
cord-334907-l4jjb93l	201	32	receptor	receptor	NN
cord-334907-l4jjb93l	201	33	binding	binding	NN
cord-334907-l4jjb93l	201	34	;	;	:
cord-334907-l4jjb93l	201	35	although	although	IN
cord-334907-l4jjb93l	201	36	this	this	DT
cord-334907-l4jjb93l	201	37	model	model	NN
cord-334907-l4jjb93l	201	38	is	be	VBZ
cord-334907-l4jjb93l	201	39	robust	robust	JJ
cord-334907-l4jjb93l	201	40	,	,	,
cord-334907-l4jjb93l	201	41	no	no	DT
cord-334907-l4jjb93l	201	42	conformational	conformational	JJ
cord-334907-l4jjb93l	201	43	changes	change	NNS
cord-334907-l4jjb93l	201	44	were	be	VBD
cord-334907-l4jjb93l	201	45	detected	detect	VBN
cord-334907-l4jjb93l	201	46	on	on	IN
cord-334907-l4jjb93l	201	47	the	the	DT
cord-334907-l4jjb93l	201	48	ISAV	ISAV	NNP
cord-334907-l4jjb93l	201	49	HE	HE	NNP
cord-334907-l4jjb93l	201	50	structure	structure	NN
cord-334907-l4jjb93l	201	51	upon	upon	IN
cord-334907-l4jjb93l	201	52	receptor	receptor	NN
cord-334907-l4jjb93l	201	53	binding	binding	NN
cord-334907-l4jjb93l	201	54	,	,	,
cord-334907-l4jjb93l	201	55	and	and	CC
cord-334907-l4jjb93l	201	56	thus	thus	RB
cord-334907-l4jjb93l	201	57	,	,	,
cord-334907-l4jjb93l	201	58	HE	he	PRP
cord-334907-l4jjb93l	201	59	is	be	VBZ
cord-334907-l4jjb93l	201	60	not	not	RB
cord-334907-l4jjb93l	201	61	likely	likely	JJ
cord-334907-l4jjb93l	201	62	the	the	DT
cord-334907-l4jjb93l	201	63	trigger	trigger	NN
cord-334907-l4jjb93l	201	64	to	to	TO
cord-334907-l4jjb93l	201	65	activate	activate	VB
cord-334907-l4jjb93l	201	66	ISAV	ISAV	NNP
cord-334907-l4jjb93l	201	67	F	F	NNP
cord-334907-l4jjb93l	201	68	[	[	-LRB-
cord-334907-l4jjb93l	201	69	11	11	CD
cord-334907-l4jjb93l	201	70	,	,	,
cord-334907-l4jjb93l	201	71	19	19	CD
cord-334907-l4jjb93l	201	72	]	]	-RRB-
cord-334907-l4jjb93l	201	73	.	.	.
cord-334907-l4jjb93l	202	1	On	on	IN
cord-334907-l4jjb93l	202	2	the	the	DT
cord-334907-l4jjb93l	202	3	other	other	JJ
cord-334907-l4jjb93l	202	4	hand	hand	NN
cord-334907-l4jjb93l	202	5	,	,	,
cord-334907-l4jjb93l	202	6	there	there	EX
cord-334907-l4jjb93l	202	7	have	have	VBP
cord-334907-l4jjb93l	202	8	been	be	VBN
cord-334907-l4jjb93l	202	9	no	no	DT
cord-334907-l4jjb93l	202	10	reports	report	NNS
cord-334907-l4jjb93l	202	11	of	of	IN
cord-334907-l4jjb93l	202	12	a	a	DT
cord-334907-l4jjb93l	202	13	direct	direct	JJ
cord-334907-l4jjb93l	202	14	interaction	interaction	NN
cord-334907-l4jjb93l	202	15	of	of	IN
cord-334907-l4jjb93l	202	16	the	the	DT
cord-334907-l4jjb93l	202	17	fusion	fusion	NN
cord-334907-l4jjb93l	202	18	protein	protein	NN
cord-334907-l4jjb93l	202	19	of	of	IN
cord-334907-l4jjb93l	202	20	ISAV	ISAV	NNP
cord-334907-l4jjb93l	202	21	with	with	IN
cord-334907-l4jjb93l	202	22	the	the	DT
cord-334907-l4jjb93l	202	23	cell	cell	NN
cord-334907-l4jjb93l	202	24	,	,	,
cord-334907-l4jjb93l	202	25	prior	prior	RB
cord-334907-l4jjb93l	202	26	to	to	IN
cord-334907-l4jjb93l	202	27	the	the	DT
cord-334907-l4jjb93l	202	28	conformational	conformational	JJ
cord-334907-l4jjb93l	202	29	change	change	NN
cord-334907-l4jjb93l	202	30	and	and	CC
cord-334907-l4jjb93l	202	31	insertion	insertion	NN
cord-334907-l4jjb93l	202	32	of	of	IN
cord-334907-l4jjb93l	202	33	the	the	DT
cord-334907-l4jjb93l	202	34	fusion	fusion	NN
cord-334907-l4jjb93l	202	35	peptide	peptide	NN
cord-334907-l4jjb93l	202	36	.	.	.
cord-334907-l4jjb93l	203	1	The	the	DT
cord-334907-l4jjb93l	203	2	equilibrium	equilibrium	NN
cord-334907-l4jjb93l	203	3	between	between	IN
cord-334907-l4jjb93l	203	4	the	the	DT
cord-334907-l4jjb93l	203	5	receptor	receptor	NN
cord-334907-l4jjb93l	203	6	-	-	HYPH
cord-334907-l4jjb93l	203	7	binding	bind	VBG
cord-334907-l4jjb93l	203	8	and	and	CC
cord-334907-l4jjb93l	203	9	-destroying	-destroying	NN
cord-334907-l4jjb93l	203	10	activities	activity	NNS
cord-334907-l4jjb93l	203	11	is	be	VBZ
cord-334907-l4jjb93l	203	12	a	a	DT
cord-334907-l4jjb93l	203	13	key	key	JJ
cord-334907-l4jjb93l	203	14	element	element	NN
cord-334907-l4jjb93l	203	15	for	for	IN
cord-334907-l4jjb93l	203	16	the	the	DT
cord-334907-l4jjb93l	203	17	infective	infective	JJ
cord-334907-l4jjb93l	203	18	process	process	NN
cord-334907-l4jjb93l	203	19	,	,	,
cord-334907-l4jjb93l	203	20	not	not	RB
cord-334907-l4jjb93l	203	21	only	only	RB
cord-334907-l4jjb93l	203	22	in	in	IN
cord-334907-l4jjb93l	203	23	terms	term	NNS
cord-334907-l4jjb93l	203	24	of	of	IN
cord-334907-l4jjb93l	203	25	the	the	DT
cord-334907-l4jjb93l	203	26	"	"	``
cord-334907-l4jjb93l	203	27	input	input	NN
cord-334907-l4jjb93l	203	28	/	/	SYM
cord-334907-l4jjb93l	203	29	output	output	NN
cord-334907-l4jjb93l	203	30	"	"	``
cord-334907-l4jjb93l	203	31	ratio	ratio	NN
cord-334907-l4jjb93l	203	32	of	of	IN
cord-334907-l4jjb93l	203	33	viral	viral	JJ
cord-334907-l4jjb93l	203	34	particles	particle	NNS
cord-334907-l4jjb93l	203	35	,	,	,
cord-334907-l4jjb93l	203	36	but	but	CC
cord-334907-l4jjb93l	203	37	also	also	RB
cord-334907-l4jjb93l	203	38	in	in	IN
cord-334907-l4jjb93l	203	39	the	the	DT
cord-334907-l4jjb93l	203	40	initial	initial	JJ
cord-334907-l4jjb93l	203	41	interaction	interaction	NN
cord-334907-l4jjb93l	203	42	of	of	IN
cord-334907-l4jjb93l	203	43	the	the	DT
cord-334907-l4jjb93l	203	44	pathogen	pathogen	NN
cord-334907-l4jjb93l	203	45	with	with	IN
cord-334907-l4jjb93l	203	46	the	the	DT
cord-334907-l4jjb93l	203	47	cell	cell	NN
cord-334907-l4jjb93l	203	48	surface	surface	NN
cord-334907-l4jjb93l	203	49	[	[	-LRB-
cord-334907-l4jjb93l	203	50	37	37	CD
cord-334907-l4jjb93l	203	51	,	,	,
cord-334907-l4jjb93l	203	52	40	40	CD
cord-334907-l4jjb93l	203	53	]	]	-RRB-
cord-334907-l4jjb93l	203	54	.	.	.
cord-334907-l4jjb93l	204	1	In	in	IN
cord-334907-l4jjb93l	204	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	204	3	,	,	,
cord-334907-l4jjb93l	204	4	if	if	IN
cord-334907-l4jjb93l	204	5	the	the	DT
cord-334907-l4jjb93l	204	6	primary	primary	JJ
cord-334907-l4jjb93l	204	7	receptor	receptor	NN
cord-334907-l4jjb93l	204	8	(	(	-LRB-
cord-334907-l4jjb93l	204	9	5N-4O	5n-4o	CD
cord-334907-l4jjb93l	204	10	sialic	sialic	JJ
cord-334907-l4jjb93l	204	11	acids	acid	NNS
cord-334907-l4jjb93l	204	12	)	)	-RRB-
cord-334907-l4jjb93l	204	13	binding	bind	VBG
cord-334907-l4jjb93l	204	14	via	via	IN
cord-334907-l4jjb93l	205	1	HE	he	PRP
cord-334907-l4jjb93l	205	2	is	be	VBZ
cord-334907-l4jjb93l	205	3	not	not	RB
cord-334907-l4jjb93l	205	4	affected	affect	VBN
cord-334907-l4jjb93l	205	5	by	by	IN
cord-334907-l4jjb93l	205	6	the	the	DT
cord-334907-l4jjb93l	205	7	HPR	HPR	NNP
cord-334907-l4jjb93l	205	8	length	length	NN
cord-334907-l4jjb93l	205	9	/	/	SYM
cord-334907-l4jjb93l	205	10	esterase	esterase	NN
cord-334907-l4jjb93l	205	11	activity	activity	NN
cord-334907-l4jjb93l	205	12	,	,	,
cord-334907-l4jjb93l	205	13	possibly	possibly	RB
cord-334907-l4jjb93l	205	14	a	a	DT
cord-334907-l4jjb93l	205	15	secondary	secondary	JJ
cord-334907-l4jjb93l	205	16	viral	viral	JJ
cord-334907-l4jjb93l	205	17	protein	protein	NN
cord-334907-l4jjb93l	205	18	-	-	HYPH
cord-334907-l4jjb93l	205	19	cellular	cellular	JJ
cord-334907-l4jjb93l	205	20	ligand	ligand	NN
cord-334907-l4jjb93l	205	21	interaction	interaction	NN
cord-334907-l4jjb93l	205	22	is	be	VBZ
cord-334907-l4jjb93l	205	23	regulated	regulate	VBN
cord-334907-l4jjb93l	205	24	by	by	IN
cord-334907-l4jjb93l	205	25	those	those	DT
cord-334907-l4jjb93l	205	26	elements	element	NNS
cord-334907-l4jjb93l	205	27	.	.	.
cord-334907-l4jjb93l	206	1	Considering	consider	VBG
cord-334907-l4jjb93l	206	2	these	these	DT
cord-334907-l4jjb93l	206	3	findings	finding	NNS
cord-334907-l4jjb93l	206	4	,	,	,
cord-334907-l4jjb93l	206	5	we	-PRON-	PRP
cord-334907-l4jjb93l	206	6	postulated	postulate	VBD
cord-334907-l4jjb93l	206	7	a	a	DT
cord-334907-l4jjb93l	206	8	putative	putative	JJ
cord-334907-l4jjb93l	206	9	interaction	interaction	NN
cord-334907-l4jjb93l	206	10	of	of	IN
cord-334907-l4jjb93l	206	11	F	F	NNP
cord-334907-l4jjb93l	206	12	,	,	,
cord-334907-l4jjb93l	206	13	prior	prior	RB
cord-334907-l4jjb93l	206	14	to	to	IN
cord-334907-l4jjb93l	206	15	activation	activation	NN
cord-334907-l4jjb93l	206	16	,	,	,
cord-334907-l4jjb93l	206	17	with	with	IN
cord-334907-l4jjb93l	206	18	a	a	DT
cord-334907-l4jjb93l	206	19	cell	cell	NN
cord-334907-l4jjb93l	206	20	receptor	receptor	NN
cord-334907-l4jjb93l	206	21	.	.	.
cord-334907-l4jjb93l	207	1	There	there	EX
cord-334907-l4jjb93l	207	2	have	have	VBP
cord-334907-l4jjb93l	207	3	been	be	VBN
cord-334907-l4jjb93l	207	4	no	no	DT
cord-334907-l4jjb93l	207	5	reports	report	NNS
cord-334907-l4jjb93l	207	6	of	of	IN
cord-334907-l4jjb93l	207	7	an	an	DT
cord-334907-l4jjb93l	207	8	experimental	experimental	JJ
cord-334907-l4jjb93l	207	9	structure	structure	NN
cord-334907-l4jjb93l	207	10	for	for	IN
cord-334907-l4jjb93l	207	11	the	the	DT
cord-334907-l4jjb93l	207	12	ISAV	ISAV	NNP
cord-334907-l4jjb93l	207	13	F	F	NNP
cord-334907-l4jjb93l	207	14	1	1	CD
cord-334907-l4jjb93l	207	15	subunit	subunit	NN
cord-334907-l4jjb93l	207	16	,	,	,
cord-334907-l4jjb93l	207	17	and	and	CC
cord-334907-l4jjb93l	207	18	protein	protein	NN
cord-334907-l4jjb93l	207	19	sequence	sequence	NN
cord-334907-l4jjb93l	207	20	homology	homology	NN
cord-334907-l4jjb93l	207	21	to	to	IN
cord-334907-l4jjb93l	207	22	proteins	protein	NNS
cord-334907-l4jjb93l	207	23	from	from	IN
cord-334907-l4jjb93l	207	24	other	other	JJ
cord-334907-l4jjb93l	207	25	species	specie	NNS
cord-334907-l4jjb93l	207	26	is	be	VBZ
cord-334907-l4jjb93l	207	27	very	very	RB
cord-334907-l4jjb93l	207	28	low	low	JJ
cord-334907-l4jjb93l	207	29	,	,	,
cord-334907-l4jjb93l	207	30	which	which	WDT
cord-334907-l4jjb93l	207	31	makes	make	VBZ
cord-334907-l4jjb93l	207	32	it	-PRON-	PRP
cord-334907-l4jjb93l	207	33	very	very	RB
cord-334907-l4jjb93l	207	34	difficult	difficult	JJ
cord-334907-l4jjb93l	207	35	to	to	TO
cord-334907-l4jjb93l	207	36	project	project	VB
cord-334907-l4jjb93l	207	37	a	a	DT
cord-334907-l4jjb93l	207	38	model	model	NN
cord-334907-l4jjb93l	207	39	structure	structure	NN
cord-334907-l4jjb93l	207	40	or	or	CC
cord-334907-l4jjb93l	207	41	function	function	NN
cord-334907-l4jjb93l	207	42	to	to	IN
cord-334907-l4jjb93l	207	43	this	this	DT
cord-334907-l4jjb93l	207	44	domain	domain	NN
cord-334907-l4jjb93l	207	45	.	.	.
cord-334907-l4jjb93l	208	1	Hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	208	2	tertiary	tertiary	JJ
cord-334907-l4jjb93l	208	3	structures	structure	NNS
cord-334907-l4jjb93l	208	4	are	be	VBP
cord-334907-l4jjb93l	208	5	relatively	relatively	RB
cord-334907-l4jjb93l	208	6	conserved	conserved	JJ
cord-334907-l4jjb93l	208	7	among	among	IN
cord-334907-l4jjb93l	208	8	species	specie	NNS
cord-334907-l4jjb93l	208	9	,	,	,
cord-334907-l4jjb93l	208	10	even	even	RB
cord-334907-l4jjb93l	208	11	though	though	IN
cord-334907-l4jjb93l	208	12	they	-PRON-	PRP
cord-334907-l4jjb93l	208	13	share	share	VBP
cord-334907-l4jjb93l	208	14	modest	modest	JJ
cord-334907-l4jjb93l	208	15	sequence	sequence	NN
cord-334907-l4jjb93l	208	16	homology	homology	NN
cord-334907-l4jjb93l	208	17	[	[	-LRB-
cord-334907-l4jjb93l	208	18	32	32	CD
cord-334907-l4jjb93l	208	19	,	,	,
cord-334907-l4jjb93l	208	20	41	41	CD
cord-334907-l4jjb93l	208	21	]	]	-RRB-
cord-334907-l4jjb93l	208	22	.	.	.
cord-334907-l4jjb93l	209	1	Furthermore	furthermore	RB
cord-334907-l4jjb93l	209	2	,	,	,
cord-334907-l4jjb93l	209	3	the	the	DT
cord-334907-l4jjb93l	209	4	F	F	NNP
cord-334907-l4jjb93l	209	5	2	2	CD
cord-334907-l4jjb93l	209	6	domain	domain	NN
cord-334907-l4jjb93l	209	7	of	of	IN
cord-334907-l4jjb93l	209	8	ISAV	ISAV	NNP
cord-334907-l4jjb93l	209	9	F	F	NNP
cord-334907-l4jjb93l	209	10	bears	bear	VBZ
cord-334907-l4jjb93l	209	11	structural	structural	JJ
cord-334907-l4jjb93l	209	12	homology	homology	NN
cord-334907-l4jjb93l	209	13	to	to	IN
cord-334907-l4jjb93l	209	14	the	the	DT
cord-334907-l4jjb93l	209	15	fusion	fusion	NN
cord-334907-l4jjb93l	209	16	domain	domain	NN
cord-334907-l4jjb93l	209	17	of	of	IN
cord-334907-l4jjb93l	209	18	influenza	influenza	NN
cord-334907-l4jjb93l	209	19	virus	virus	NN
cord-334907-l4jjb93l	209	20	HA	HA	NNP
cord-334907-l4jjb93l	209	21	,	,	,
cord-334907-l4jjb93l	209	22	that	that	RB
cord-334907-l4jjb93l	209	23	is	is	RB
cord-334907-l4jjb93l	209	24	,	,	,
cord-334907-l4jjb93l	209	25	a	a	DT
cord-334907-l4jjb93l	209	26	coiled	coiled	JJ
cord-334907-l4jjb93l	209	27	coil	coil	NN
cord-334907-l4jjb93l	209	28	structure	structure	NN
cord-334907-l4jjb93l	209	29	and	and	CC
cord-334907-l4jjb93l	209	30	a	a	DT
cord-334907-l4jjb93l	209	31	hydrophobic	hydrophobic	JJ
cord-334907-l4jjb93l	209	32	fusion	fusion	NN
cord-334907-l4jjb93l	209	33	peptide	peptide	NN
cord-334907-l4jjb93l	209	34	,	,	,
cord-334907-l4jjb93l	209	35	which	which	WDT
cord-334907-l4jjb93l	209	36	suggest	suggest	VBP
cord-334907-l4jjb93l	209	37	a	a	DT
cord-334907-l4jjb93l	209	38	conserved	conserve	VBN
cord-334907-l4jjb93l	209	39	structure	structure	NN
cord-334907-l4jjb93l	209	40	for	for	IN
cord-334907-l4jjb93l	209	41	the	the	DT
cord-334907-l4jjb93l	209	42	amino	amino	NN
cord-334907-l4jjb93l	209	43	-	-	HYPH
cord-334907-l4jjb93l	209	44	terminal	terminal	NN
cord-334907-l4jjb93l	209	45	domain	domain	NN
cord-334907-l4jjb93l	209	46	as	as	RB
cord-334907-l4jjb93l	209	47	well	well	RB
cord-334907-l4jjb93l	209	48	.	.	.
cord-334907-l4jjb93l	210	1	Effectively	effectively	RB
cord-334907-l4jjb93l	210	2	,	,	,
cord-334907-l4jjb93l	210	3	a	a	DT
cord-334907-l4jjb93l	210	4	secondary	secondary	JJ
cord-334907-l4jjb93l	210	5	structure	structure	NN
cord-334907-l4jjb93l	210	6	prediction	prediction	NN
cord-334907-l4jjb93l	210	7	for	for	IN
cord-334907-l4jjb93l	210	8	the	the	DT
cord-334907-l4jjb93l	210	9	ISAV	ISAV	NNP
cord-334907-l4jjb93l	210	10	fusion	fusion	NN
cord-334907-l4jjb93l	210	11	protein	protein	NN
cord-334907-l4jjb93l	210	12	revealed	reveal	VBD
cord-334907-l4jjb93l	210	13	a	a	DT
cord-334907-l4jjb93l	210	14	high	high	JJ
cord-334907-l4jjb93l	210	15	content	content	NN
cord-334907-l4jjb93l	210	16	of	of	IN
cord-334907-l4jjb93l	210	17	beta	beta	JJ
cord-334907-l4jjb93l	210	18	sheets	sheet	NNS
cord-334907-l4jjb93l	210	19	,	,	,
cord-334907-l4jjb93l	210	20	which	which	WDT
cord-334907-l4jjb93l	210	21	is	be	VBZ
cord-334907-l4jjb93l	210	22	characteristic	characteristic	JJ
cord-334907-l4jjb93l	210	23	of	of	IN
cord-334907-l4jjb93l	210	24	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	210	25	domains	domain	NNS
cord-334907-l4jjb93l	210	26	,	,	,
cord-334907-l4jjb93l	210	27	forming	form	VBG
cord-334907-l4jjb93l	210	28	a	a	DT
cord-334907-l4jjb93l	210	29	Swiss	swiss	JJ
cord-334907-l4jjb93l	210	30	roll	roll	NN
cord-334907-l4jjb93l	210	31	type	type	NN
cord-334907-l4jjb93l	210	32	structure	structure	NN
cord-334907-l4jjb93l	210	33	(	(	-LRB-
cord-334907-l4jjb93l	210	34	Figure	figure	NN
cord-334907-l4jjb93l	210	35	1	1	CD
cord-334907-l4jjb93l	210	36	)	)	-RRB-
cord-334907-l4jjb93l	210	37	[	[	-LRB-
cord-334907-l4jjb93l	210	38	42	42	CD
cord-334907-l4jjb93l	210	39	]	]	-RRB-
cord-334907-l4jjb93l	210	40	.	.	.
cord-334907-l4jjb93l	211	1	Sequence	sequence	NN
cord-334907-l4jjb93l	211	2	alignment	alignment	NN
cord-334907-l4jjb93l	211	3	allowed	allow	VBN
cord-334907-l4jjb93l	211	4	for	for	IN
cord-334907-l4jjb93l	211	5	comparative	comparative	JJ
cord-334907-l4jjb93l	211	6	modeling	modeling	NN
cord-334907-l4jjb93l	211	7	of	of	IN
cord-334907-l4jjb93l	211	8	a	a	DT
cord-334907-l4jjb93l	211	9	subdomain	subdomain	NN
cord-334907-l4jjb93l	211	10	in	in	IN
cord-334907-l4jjb93l	211	11	F	F	NNP
cord-334907-l4jjb93l	211	12	1	1	CD
cord-334907-l4jjb93l	211	13	using	use	VBG
cord-334907-l4jjb93l	211	14	the	the	DT
cord-334907-l4jjb93l	211	15	structure	structure	NN
cord-334907-l4jjb93l	211	16	of	of	IN
cord-334907-l4jjb93l	211	17	the	the	DT
cord-334907-l4jjb93l	211	18	PToV	PToV	NNP
cord-334907-l4jjb93l	211	19	HE	HE	NNP
cord-334907-l4jjb93l	211	20	as	as	IN
cord-334907-l4jjb93l	211	21	template	template	NN
cord-334907-l4jjb93l	211	22	(	(	-LRB-
cord-334907-l4jjb93l	211	23	Figure	figure	NN
cord-334907-l4jjb93l	211	24	2	2	CD
cord-334907-l4jjb93l	211	25	)	)	-RRB-
cord-334907-l4jjb93l	211	26	.	.	.
cord-334907-l4jjb93l	212	1	Although	although	IN
cord-334907-l4jjb93l	212	2	there	there	EX
cord-334907-l4jjb93l	212	3	is	be	VBZ
cord-334907-l4jjb93l	212	4	a	a	DT
cord-334907-l4jjb93l	212	5	low	low	JJ
cord-334907-l4jjb93l	212	6	level	level	NN
cord-334907-l4jjb93l	212	7	of	of	IN
cord-334907-l4jjb93l	212	8	amino	amino	NN
cord-334907-l4jjb93l	212	9	acid	acid	NN
cord-334907-l4jjb93l	212	10	conservation	conservation	NN
cord-334907-l4jjb93l	212	11	between	between	IN
cord-334907-l4jjb93l	212	12	model	model	NN
cord-334907-l4jjb93l	212	13	and	and	CC
cord-334907-l4jjb93l	212	14	template	template	NN
cord-334907-l4jjb93l	212	15	(	(	-LRB-
cord-334907-l4jjb93l	212	16	38.31	38.31	CD
cord-334907-l4jjb93l	212	17	%	%	NN
cord-334907-l4jjb93l	212	18	identity	identity	NN
cord-334907-l4jjb93l	212	19	)	)	-RRB-
cord-334907-l4jjb93l	212	20	,	,	,
cord-334907-l4jjb93l	212	21	there	there	EX
cord-334907-l4jjb93l	212	22	is	be	VBZ
cord-334907-l4jjb93l	212	23	structural	structural	JJ
cord-334907-l4jjb93l	212	24	homology	homology	NN
cord-334907-l4jjb93l	212	25	between	between	IN
cord-334907-l4jjb93l	212	26	the	the	DT
cord-334907-l4jjb93l	212	27	proteins	protein	NNS
cord-334907-l4jjb93l	212	28	,	,	,
cord-334907-l4jjb93l	212	29	considering	consider	VBG
cord-334907-l4jjb93l	212	30	the	the	DT
cord-334907-l4jjb93l	212	31	presence	presence	NN
cord-334907-l4jjb93l	212	32	of	of	IN
cord-334907-l4jjb93l	212	33	beta	beta	NN
cord-334907-l4jjb93l	212	34	sheets	sheet	NNS
cord-334907-l4jjb93l	212	35	in	in	IN
cord-334907-l4jjb93l	212	36	both	both	DT
cord-334907-l4jjb93l	212	37	and	and	CC
cord-334907-l4jjb93l	212	38	the	the	DT
cord-334907-l4jjb93l	212	39	location	location	NN
cord-334907-l4jjb93l	212	40	of	of	IN
cord-334907-l4jjb93l	212	41	particular	particular	JJ
cord-334907-l4jjb93l	212	42	hydrophobic	hydrophobic	JJ
cord-334907-l4jjb93l	212	43	residues	residue	NNS
cord-334907-l4jjb93l	212	44	[	[	-LRB-
cord-334907-l4jjb93l	212	45	32	32	CD
cord-334907-l4jjb93l	212	46	]	]	-RRB-
cord-334907-l4jjb93l	212	47	.	.	.
cord-334907-l4jjb93l	213	1	Typically	typically	RB
cord-334907-l4jjb93l	213	2	in	in	IN
cord-334907-l4jjb93l	213	3	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	213	4	,	,	,
cord-334907-l4jjb93l	213	5	hydrophobic	hydrophobic	JJ
cord-334907-l4jjb93l	213	6	amino	amino	NN
cord-334907-l4jjb93l	213	7	acids	acid	NNS
cord-334907-l4jjb93l	213	8	located	locate	VBN
cord-334907-l4jjb93l	213	9	between	between	IN
cord-334907-l4jjb93l	213	10	the	the	DT
cord-334907-l4jjb93l	213	11	beta	beta	NN
cord-334907-l4jjb93l	213	12	strands	strand	NNS
cord-334907-l4jjb93l	213	13	are	be	VBP
cord-334907-l4jjb93l	213	14	directly	directly	RB
cord-334907-l4jjb93l	213	15	involved	involve	VBN
cord-334907-l4jjb93l	213	16	in	in	IN
cord-334907-l4jjb93l	213	17	ligand	ligand	NN
cord-334907-l4jjb93l	213	18	binding	bind	VBG
cord-334907-l4jjb93l	213	19	[	[	-LRB-
cord-334907-l4jjb93l	213	20	32	32	CD
cord-334907-l4jjb93l	213	21	,	,	,
cord-334907-l4jjb93l	213	22	[	[	-LRB-
cord-334907-l4jjb93l	213	23	42	42	CD
cord-334907-l4jjb93l	213	24	]	]	-RRB-
cord-334907-l4jjb93l	213	25	[	[	-LRB-
cord-334907-l4jjb93l	213	26	43	43	CD
cord-334907-l4jjb93l	213	27	]	]	-RRB-
cord-334907-l4jjb93l	213	28	[	[	-LRB-
cord-334907-l4jjb93l	213	29	44	44	CD
cord-334907-l4jjb93l	213	30	]	]	-RRB-
cord-334907-l4jjb93l	213	31	[	[	-LRB-
cord-334907-l4jjb93l	213	32	45	45	CD
cord-334907-l4jjb93l	213	33	]	]	-RRB-
cord-334907-l4jjb93l	213	34	.	.	.
cord-334907-l4jjb93l	214	1	Using	use	VBG
cord-334907-l4jjb93l	214	2	heterologous	heterologous	JJ
cord-334907-l4jjb93l	214	3	expression	expression	NN
cord-334907-l4jjb93l	214	4	of	of	IN
cord-334907-l4jjb93l	214	5	ISAV	ISAV	NNP
cord-334907-l4jjb93l	214	6	HE	HE	NNP
cord-334907-l4jjb93l	214	7	and	and	CC
cord-334907-l4jjb93l	214	8	F	F	NNP
cord-334907-l4jjb93l	214	9	,	,	,
cord-334907-l4jjb93l	214	10	we	-PRON-	PRP
cord-334907-l4jjb93l	214	11	have	have	VBP
cord-334907-l4jjb93l	214	12	previously	previously	RB
cord-334907-l4jjb93l	214	13	obtained	obtain	VBN
cord-334907-l4jjb93l	214	14	soluble	soluble	JJ
cord-334907-l4jjb93l	214	15	,	,	,
cord-334907-l4jjb93l	214	16	3xFLAGtagged	3xflagtagged	CD
cord-334907-l4jjb93l	214	17	versions	version	NNS
cord-334907-l4jjb93l	214	18	of	of	IN
cord-334907-l4jjb93l	214	19	the	the	DT
cord-334907-l4jjb93l	214	20	viral	viral	JJ
cord-334907-l4jjb93l	214	21	proteins	protein	NNS
cord-334907-l4jjb93l	214	22	[	[	-LRB-
cord-334907-l4jjb93l	214	23	35	35	CD
cord-334907-l4jjb93l	214	24	]	]	-RRB-
cord-334907-l4jjb93l	214	25	.	.	.
cord-334907-l4jjb93l	215	1	These	these	DT
cord-334907-l4jjb93l	215	2	were	be	VBD
cord-334907-l4jjb93l	215	3	used	use	VBN
cord-334907-l4jjb93l	215	4	to	to	TO
cord-334907-l4jjb93l	215	5	perform	perform	VB
cord-334907-l4jjb93l	215	6	lectin	lectin	NN
cord-334907-l4jjb93l	215	7	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	215	8	assays	assay	NNS
cord-334907-l4jjb93l	215	9	on	on	IN
cord-334907-l4jjb93l	215	10	ASK	ask	NN
cord-334907-l4jjb93l	215	11	cells	cell	NNS
cord-334907-l4jjb93l	215	12	,	,	,
cord-334907-l4jjb93l	215	13	a	a	DT
cord-334907-l4jjb93l	215	14	fish	fish	NN
cord-334907-l4jjb93l	215	15	cell	cell	NN
cord-334907-l4jjb93l	215	16	line	line	NN
cord-334907-l4jjb93l	215	17	conventionally	conventionally	RB
cord-334907-l4jjb93l	215	18	permissive	permissive	JJ
cord-334907-l4jjb93l	215	19	to	to	IN
cord-334907-l4jjb93l	215	20	ISAV	ISAV	NNP
cord-334907-l4jjb93l	215	21	infection	infection	NN
cord-334907-l4jjb93l	215	22	.	.	.
cord-334907-l4jjb93l	216	1	The	the	DT
cord-334907-l4jjb93l	216	2	assays	assay	NNS
cord-334907-l4jjb93l	216	3	revealed	reveal	VBD
cord-334907-l4jjb93l	216	4	a	a	DT
cord-334907-l4jjb93l	216	5	clear	clear	JJ
cord-334907-l4jjb93l	216	6	interaction	interaction	NN
cord-334907-l4jjb93l	216	7	of	of	IN
cord-334907-l4jjb93l	216	8	both	both	DT
cord-334907-l4jjb93l	216	9	rHE	rHE	NNP
cord-334907-l4jjb93l	216	10	and	and	CC
cord-334907-l4jjb93l	216	11	rF	rF	NNP
cord-334907-l4jjb93l	216	12	with	with	IN
cord-334907-l4jjb93l	216	13	a	a	DT
cord-334907-l4jjb93l	216	14	cellular	cellular	JJ
cord-334907-l4jjb93l	216	15	element	element	NN
cord-334907-l4jjb93l	216	16	,	,	,
cord-334907-l4jjb93l	216	17	possibly	possibly	RB
cord-334907-l4jjb93l	216	18	a	a	DT
cord-334907-l4jjb93l	216	19	membrane	membrane	NN
cord-334907-l4jjb93l	216	20	-	-	HYPH
cord-334907-l4jjb93l	216	21	bound	bind	VBN
cord-334907-l4jjb93l	216	22	ligand	ligand	NN
cord-334907-l4jjb93l	216	23	(	(	-LRB-
cord-334907-l4jjb93l	216	24	Figure	figure	NN
cord-334907-l4jjb93l	216	25	3a	3a	NN
cord-334907-l4jjb93l	216	26	,	,	,
cord-334907-l4jjb93l	216	27	b	b	NN
cord-334907-l4jjb93l	216	28	)	)	-RRB-
cord-334907-l4jjb93l	216	29	.	.	.
cord-334907-l4jjb93l	217	1	Interaction	Interaction	NNP
cord-334907-l4jjb93l	217	2	of	of	IN
cord-334907-l4jjb93l	217	3	rF	rF	NNP
cord-334907-l4jjb93l	217	4	with	with	IN
cord-334907-l4jjb93l	217	5	its	-PRON-	PRP$
cord-334907-l4jjb93l	217	6	putative	putative	JJ
cord-334907-l4jjb93l	217	7	receptor	receptor	NN
cord-334907-l4jjb93l	217	8	was	be	VBD
cord-334907-l4jjb93l	217	9	hampered	hamper	VBN
cord-334907-l4jjb93l	217	10	by	by	IN
cord-334907-l4jjb93l	217	11	preincubation	preincubation	NN
cord-334907-l4jjb93l	217	12	of	of	IN
cord-334907-l4jjb93l	217	13	the	the	DT
cord-334907-l4jjb93l	217	14	cells	cell	NNS
cord-334907-l4jjb93l	217	15	with	with	IN
cord-334907-l4jjb93l	217	16	rHE	rHE	NNP
cord-334907-l4jjb93l	217	17	,	,	,
cord-334907-l4jjb93l	217	18	suggesting	suggest	VBG
cord-334907-l4jjb93l	217	19	a	a	DT
cord-334907-l4jjb93l	217	20	competition	competition	NN
cord-334907-l4jjb93l	217	21	for	for	IN
cord-334907-l4jjb93l	217	22	the	the	DT
cord-334907-l4jjb93l	217	23	cellular	cellular	JJ
cord-334907-l4jjb93l	217	24	ligand	ligand	NN
cord-334907-l4jjb93l	217	25	between	between	IN
cord-334907-l4jjb93l	217	26	the	the	DT
cord-334907-l4jjb93l	217	27	two	two	CD
cord-334907-l4jjb93l	217	28	proteins	protein	NNS
cord-334907-l4jjb93l	217	29	(	(	-LRB-
cord-334907-l4jjb93l	217	30	Figure	Figure	NNP
cord-334907-l4jjb93l	217	31	3e	3e	NN
cord-334907-l4jjb93l	217	32	)	)	-RRB-
cord-334907-l4jjb93l	217	33	.	.	.
cord-334907-l4jjb93l	218	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	218	2	,	,	,
cord-334907-l4jjb93l	218	3	treatment	treatment	NN
cord-334907-l4jjb93l	218	4	of	of	IN
cord-334907-l4jjb93l	218	5	rHE	rHE	NNP
cord-334907-l4jjb93l	218	6	with	with	IN
cord-334907-l4jjb93l	218	7	DCIC	DCIC	NNP
cord-334907-l4jjb93l	218	8	,	,	,
cord-334907-l4jjb93l	218	9	an	an	DT
cord-334907-l4jjb93l	218	10	esterase	esterase	NN
cord-334907-l4jjb93l	218	11	inhibitor	inhibitor	NN
cord-334907-l4jjb93l	218	12	,	,	,
cord-334907-l4jjb93l	218	13	reverted	revert	VBD
cord-334907-l4jjb93l	218	14	the	the	DT
cord-334907-l4jjb93l	218	15	effect	effect	NN
cord-334907-l4jjb93l	218	16	,	,	,
cord-334907-l4jjb93l	218	17	suggesting	suggest	VBG
cord-334907-l4jjb93l	218	18	that	that	IN
cord-334907-l4jjb93l	218	19	the	the	DT
cord-334907-l4jjb93l	218	20	enzyme	enzyme	NN
cord-334907-l4jjb93l	218	21	is	be	VBZ
cord-334907-l4jjb93l	218	22	responsible	responsible	JJ
cord-334907-l4jjb93l	218	23	for	for	IN
cord-334907-l4jjb93l	218	24	the	the	DT
cord-334907-l4jjb93l	218	25	blockage	blockage	NN
cord-334907-l4jjb93l	218	26	of	of	IN
cord-334907-l4jjb93l	218	27	the	the	DT
cord-334907-l4jjb93l	218	28	interaction	interaction	NN
cord-334907-l4jjb93l	218	29	of	of	IN
cord-334907-l4jjb93l	218	30	rF	rf	NN
cord-334907-l4jjb93l	218	31	with	with	IN
cord-334907-l4jjb93l	218	32	the	the	DT
cord-334907-l4jjb93l	218	33	cell	cell	NN
cord-334907-l4jjb93l	218	34	(	(	-LRB-
cord-334907-l4jjb93l	218	35	Figure	figure	NN
cord-334907-l4jjb93l	218	36	3f	3f	NN
cord-334907-l4jjb93l	218	37	)	)	-RRB-
cord-334907-l4jjb93l	218	38	.	.	.
cord-334907-l4jjb93l	219	1	ISAV	ISAV	NNP
cord-334907-l4jjb93l	219	2	esterase	esterase	NN
cord-334907-l4jjb93l	219	3	has	have	VBZ
cord-334907-l4jjb93l	219	4	shown	show	VBN
cord-334907-l4jjb93l	219	5	activity	activity	NN
cord-334907-l4jjb93l	219	6	against	against	IN
cord-334907-l4jjb93l	219	7	a	a	DT
cord-334907-l4jjb93l	219	8	variety	variety	NN
cord-334907-l4jjb93l	219	9	of	of	IN
cord-334907-l4jjb93l	219	10	sialic	sialic	JJ
cord-334907-l4jjb93l	219	11	acids	acid	NNS
cord-334907-l4jjb93l	219	12	,	,	,
cord-334907-l4jjb93l	219	13	including	include	VBG
cord-334907-l4jjb93l	219	14	9-O	9-o	CD
cord-334907-l4jjb93l	219	15	-	-	HYPH
cord-334907-l4jjb93l	219	16	acetylated	acetylated	JJ
cord-334907-l4jjb93l	219	17	sialic	sialic	JJ
cord-334907-l4jjb93l	219	18	acids	acid	NNS
cord-334907-l4jjb93l	219	19	,	,	,
cord-334907-l4jjb93l	219	20	which	which	WDT
cord-334907-l4jjb93l	219	21	are	be	VBP
cord-334907-l4jjb93l	219	22	not	not	RB
cord-334907-l4jjb93l	219	23	necessarily	necessarily	RB
cord-334907-l4jjb93l	219	24	recognized	recognize	VBN
cord-334907-l4jjb93l	219	25	as	as	IN
cord-334907-l4jjb93l	219	26	receptors	receptor	NNS
cord-334907-l4jjb93l	219	27	for	for	IN
cord-334907-l4jjb93l	219	28	HE	he	PRP
cord-334907-l4jjb93l	219	29	[	[	-LRB-
cord-334907-l4jjb93l	219	30	28	28	CD
cord-334907-l4jjb93l	219	31	]	]	-RRB-
cord-334907-l4jjb93l	219	32	.	.	.
cord-334907-l4jjb93l	220	1	These	these	DT
cord-334907-l4jjb93l	220	2	results	result	NNS
cord-334907-l4jjb93l	220	3	imply	imply	VBP
cord-334907-l4jjb93l	220	4	that	that	IN
cord-334907-l4jjb93l	220	5	a	a	DT
cord-334907-l4jjb93l	220	6	sialic	sialic	JJ
cord-334907-l4jjb93l	220	7	acid	acid	NN
cord-334907-l4jjb93l	220	8	,	,	,
cord-334907-l4jjb93l	220	9	acting	act	VBG
cord-334907-l4jjb93l	220	10	as	as	IN
cord-334907-l4jjb93l	220	11	receptor	receptor	NN
cord-334907-l4jjb93l	220	12	for	for	IN
cord-334907-l4jjb93l	220	13	F	F	NNP
cord-334907-l4jjb93l	220	14	,	,	,
cord-334907-l4jjb93l	220	15	may	may	MD
cord-334907-l4jjb93l	220	16	be	be	VB
cord-334907-l4jjb93l	220	17	hydrolyzed	hydrolyze	VBN
cord-334907-l4jjb93l	220	18	by	by	IN
cord-334907-l4jjb93l	220	19	the	the	DT
cord-334907-l4jjb93l	220	20	esterase	esterase	NN
cord-334907-l4jjb93l	220	21	in	in	IN
cord-334907-l4jjb93l	220	22	HE	HE	NNP
cord-334907-l4jjb93l	220	23	.	.	.
cord-334907-l4jjb93l	221	1	Moreover	moreover	RB
cord-334907-l4jjb93l	221	2	,	,	,
cord-334907-l4jjb93l	221	3	saponification	saponification	NN
cord-334907-l4jjb93l	221	4	of	of	IN
cord-334907-l4jjb93l	221	5	the	the	DT
cord-334907-l4jjb93l	221	6	glyco	glyco	NNP
cord-334907-l4jjb93l	221	7	-	-	HYPH
cord-334907-l4jjb93l	221	8	conjugates	conjugate	NNS
cord-334907-l4jjb93l	221	9	present	present	JJ
cord-334907-l4jjb93l	221	10	on	on	IN
cord-334907-l4jjb93l	221	11	the	the	DT
cord-334907-l4jjb93l	221	12	ASK	ask	NN
cord-334907-l4jjb93l	221	13	cell	cell	NN
cord-334907-l4jjb93l	221	14	membrane	membrane	NN
cord-334907-l4jjb93l	221	15	impeded	impede	VBD
cord-334907-l4jjb93l	221	16	the	the	DT
cord-334907-l4jjb93l	221	17	interaction	interaction	NN
cord-334907-l4jjb93l	221	18	of	of	IN
cord-334907-l4jjb93l	221	19	rF	rF	NNP
cord-334907-l4jjb93l	221	20	with	with	IN
cord-334907-l4jjb93l	221	21	its	-PRON-	PRP$
cord-334907-l4jjb93l	221	22	receptor	receptor	NN
cord-334907-l4jjb93l	221	23	,	,	,
cord-334907-l4jjb93l	221	24	confirming	confirm	VBG
cord-334907-l4jjb93l	221	25	the	the	DT
cord-334907-l4jjb93l	221	26	chemical	chemical	JJ
cord-334907-l4jjb93l	221	27	nature	nature	NN
cord-334907-l4jjb93l	221	28	of	of	IN
cord-334907-l4jjb93l	221	29	the	the	DT
cord-334907-l4jjb93l	221	30	molecule	molecule	NN
cord-334907-l4jjb93l	221	31	(	(	-LRB-
cord-334907-l4jjb93l	221	32	Figure	Figure	NNP
cord-334907-l4jjb93l	221	33	3e	3e	NN
cord-334907-l4jjb93l	221	34	)	)	-RRB-
cord-334907-l4jjb93l	221	35	.	.	.
cord-334907-l4jjb93l	222	1	Interaction	Interaction	NNP
cord-334907-l4jjb93l	222	2	of	of	IN
cord-334907-l4jjb93l	222	3	rHE	rHE	NNP
cord-334907-l4jjb93l	222	4	and	and	CC
cord-334907-l4jjb93l	222	5	rF	rF	NNP
cord-334907-l4jjb93l	222	6	with	with	IN
cord-334907-l4jjb93l	222	7	target	target	NN
cord-334907-l4jjb93l	222	8	cells	cell	NNS
cord-334907-l4jjb93l	222	9	was	be	VBD
cord-334907-l4jjb93l	222	10	further	further	RB
cord-334907-l4jjb93l	222	11	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	222	12	by	by	IN
cord-334907-l4jjb93l	222	13	the	the	DT
cord-334907-l4jjb93l	222	14	inhibition	inhibition	NN
cord-334907-l4jjb93l	222	15	of	of	IN
cord-334907-l4jjb93l	222	16	ISAV	ISAV	NNP
cord-334907-l4jjb93l	222	17	infection	infection	NN
cord-334907-l4jjb93l	222	18	in	in	IN
cord-334907-l4jjb93l	222	19	lectin	lectin	NN
cord-334907-l4jjb93l	222	20	-	-	HYPH
cord-334907-l4jjb93l	222	21	treated	treat	VBN
cord-334907-l4jjb93l	222	22	ASK	ask	NN
cord-334907-l4jjb93l	222	23	cells	cell	NNS
cord-334907-l4jjb93l	222	24	.	.	.
cord-334907-l4jjb93l	223	1	Incubation	incubation	NN
cord-334907-l4jjb93l	223	2	of	of	IN
cord-334907-l4jjb93l	223	3	the	the	DT
cord-334907-l4jjb93l	223	4	cells	cell	NNS
cord-334907-l4jjb93l	223	5	with	with	IN
cord-334907-l4jjb93l	223	6	the	the	DT
cord-334907-l4jjb93l	223	7	soluble	soluble	JJ
cord-334907-l4jjb93l	223	8	lectins	lectin	NNS
cord-334907-l4jjb93l	223	9	,	,	,
cord-334907-l4jjb93l	223	10	prior	prior	RB
cord-334907-l4jjb93l	223	11	to	to	IN
cord-334907-l4jjb93l	223	12	cell	cell	NN
cord-334907-l4jjb93l	223	13	infection	infection	NN
cord-334907-l4jjb93l	223	14	,	,	,
cord-334907-l4jjb93l	223	15	blocked	block	VBD
cord-334907-l4jjb93l	223	16	the	the	DT
cord-334907-l4jjb93l	223	17	viral	viral	JJ
cord-334907-l4jjb93l	223	18	receptors	receptor	NNS
cord-334907-l4jjb93l	223	19	on	on	IN
cord-334907-l4jjb93l	223	20	the	the	DT
cord-334907-l4jjb93l	223	21	cell	cell	NN
cord-334907-l4jjb93l	223	22	surface	surface	NN
cord-334907-l4jjb93l	223	23	,	,	,
cord-334907-l4jjb93l	223	24	diminishing	diminish	VBG
cord-334907-l4jjb93l	223	25	infection	infection	NN
cord-334907-l4jjb93l	223	26	as	as	IN
cord-334907-l4jjb93l	223	27	reflected	reflect	VBN
cord-334907-l4jjb93l	223	28	by	by	IN
cord-334907-l4jjb93l	223	29	a	a	DT
cord-334907-l4jjb93l	223	30	lower	low	JJR
cord-334907-l4jjb93l	223	31	expression	expression	NN
cord-334907-l4jjb93l	223	32	of	of	IN
cord-334907-l4jjb93l	223	33	the	the	DT
cord-334907-l4jjb93l	223	34	viral	viral	JJ
cord-334907-l4jjb93l	223	35	genomic	genomic	JJ
cord-334907-l4jjb93l	223	36	segment	segment	NN
cord-334907-l4jjb93l	223	37	8	8	CD
cord-334907-l4jjb93l	223	38	as	as	IN
cord-334907-l4jjb93l	223	39	compared	compare	VBN
cord-334907-l4jjb93l	223	40	to	to	IN
cord-334907-l4jjb93l	223	41	the	the	DT
cord-334907-l4jjb93l	223	42	mock	mock	NN
cord-334907-l4jjb93l	223	43	-	-	HYPH
cord-334907-l4jjb93l	223	44	treated	treat	VBN
cord-334907-l4jjb93l	223	45	controls	control	NNS
cord-334907-l4jjb93l	223	46	(	(	-LRB-
cord-334907-l4jjb93l	223	47	Figure	figure	NN
cord-334907-l4jjb93l	223	48	4	4	CD
cord-334907-l4jjb93l	223	49	)	)	-RRB-
cord-334907-l4jjb93l	223	50	.	.	.
cord-334907-l4jjb93l	224	1	Preincubation	preincubation	NN
cord-334907-l4jjb93l	224	2	of	of	IN
cord-334907-l4jjb93l	224	3	the	the	DT
cord-334907-l4jjb93l	224	4	cells	cell	NNS
cord-334907-l4jjb93l	224	5	with	with	IN
cord-334907-l4jjb93l	224	6	rHE	rHE	NNP
cord-334907-l4jjb93l	224	7	had	have	VBD
cord-334907-l4jjb93l	224	8	a	a	DT
cord-334907-l4jjb93l	224	9	more	more	RBR
cord-334907-l4jjb93l	224	10	pronounced	pronounced	JJ
cord-334907-l4jjb93l	224	11	effect	effect	NN
cord-334907-l4jjb93l	224	12	on	on	IN
cord-334907-l4jjb93l	224	13	viral	viral	JJ
cord-334907-l4jjb93l	224	14	infection	infection	NN
cord-334907-l4jjb93l	224	15	inhibition	inhibition	NN
cord-334907-l4jjb93l	224	16	than	than	IN
cord-334907-l4jjb93l	224	17	the	the	DT
cord-334907-l4jjb93l	224	18	rF	rf	NN
cord-334907-l4jjb93l	224	19	treatment	treatment	NN
cord-334907-l4jjb93l	224	20	,	,	,
cord-334907-l4jjb93l	224	21	this	this	DT
cord-334907-l4jjb93l	224	22	being	be	VBG
cord-334907-l4jjb93l	224	23	probably	probably	RB
cord-334907-l4jjb93l	224	24	related	relate	VBN
cord-334907-l4jjb93l	224	25	to	to	IN
cord-334907-l4jjb93l	224	26	the	the	DT
cord-334907-l4jjb93l	224	27	different	different	JJ
cord-334907-l4jjb93l	224	28	strength	strength	NN
cord-334907-l4jjb93l	224	29	of	of	IN
cord-334907-l4jjb93l	224	30	the	the	DT
cord-334907-l4jjb93l	224	31	interaction	interaction	NN
cord-334907-l4jjb93l	224	32	of	of	IN
cord-334907-l4jjb93l	224	33	HE	HE	NNP
cord-334907-l4jjb93l	224	34	and	and	CC
cord-334907-l4jjb93l	224	35	F	F	NNP
cord-334907-l4jjb93l	224	36	with	with	IN
cord-334907-l4jjb93l	224	37	their	-PRON-	PRP$
cord-334907-l4jjb93l	224	38	receptors	receptor	NNS
cord-334907-l4jjb93l	224	39	.	.	.
cord-334907-l4jjb93l	225	1	Thus	thus	RB
cord-334907-l4jjb93l	225	2	,	,	,
cord-334907-l4jjb93l	225	3	the	the	DT
cord-334907-l4jjb93l	225	4	reported	reported	JJ
cord-334907-l4jjb93l	225	5	lack	lack	NN
cord-334907-l4jjb93l	225	6	of	of	IN
cord-334907-l4jjb93l	225	7	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	225	8	capacity	capacity	NN
cord-334907-l4jjb93l	225	9	on	on	IN
cord-334907-l4jjb93l	225	10	F	F	NNP
cord-334907-l4jjb93l	225	11	may	may	MD
cord-334907-l4jjb93l	225	12	be	be	VB
cord-334907-l4jjb93l	225	13	due	due	JJ
cord-334907-l4jjb93l	225	14	to	to	IN
cord-334907-l4jjb93l	225	15	a	a	DT
cord-334907-l4jjb93l	225	16	weak	weak	JJ
cord-334907-l4jjb93l	225	17	interaction	interaction	NN
cord-334907-l4jjb93l	225	18	with	with	IN
cord-334907-l4jjb93l	225	19	its	-PRON-	PRP$
cord-334907-l4jjb93l	225	20	receptor	receptor	NN
cord-334907-l4jjb93l	225	21	on	on	IN
cord-334907-l4jjb93l	225	22	RBCs	rbc	NNS
cord-334907-l4jjb93l	225	23	,	,	,
cord-334907-l4jjb93l	225	24	where	where	WRB
cord-334907-l4jjb93l	225	25	the	the	DT
cord-334907-l4jjb93l	225	26	low	low	JJ
cord-334907-l4jjb93l	225	27	-	-	HYPH
cord-334907-l4jjb93l	225	28	strength	strength	NN
cord-334907-l4jjb93l	225	29	binding	binding	NN
cord-334907-l4jjb93l	225	30	of	of	IN
cord-334907-l4jjb93l	225	31	the	the	DT
cord-334907-l4jjb93l	225	32	sialic	sialic	JJ
cord-334907-l4jjb93l	225	33	acids	acid	NNS
cord-334907-l4jjb93l	225	34	does	do	VBZ
cord-334907-l4jjb93l	225	35	not	not	RB
cord-334907-l4jjb93l	225	36	allow	allow	VB
cord-334907-l4jjb93l	225	37	the	the	DT
cord-334907-l4jjb93l	225	38	adhesion	adhesion	NN
cord-334907-l4jjb93l	225	39	and	and	CC
cord-334907-l4jjb93l	225	40	retention	retention	NN
cord-334907-l4jjb93l	225	41	of	of	IN
cord-334907-l4jjb93l	225	42	the	the	DT
cord-334907-l4jjb93l	225	43	erythrocyte	erythrocyte	NN
cord-334907-l4jjb93l	225	44	by	by	IN
cord-334907-l4jjb93l	225	45	the	the	DT
cord-334907-l4jjb93l	225	46	F	F	NNP
cord-334907-l4jjb93l	225	47	-	-	HYPH
cord-334907-l4jjb93l	225	48	expressing	express	VBG
cord-334907-l4jjb93l	225	49	cell	cell	NN
cord-334907-l4jjb93l	225	50	[	[	-LRB-
cord-334907-l4jjb93l	225	51	12	12	CD
cord-334907-l4jjb93l	225	52	]	]	-RRB-
cord-334907-l4jjb93l	225	53	.	.	.
cord-334907-l4jjb93l	226	1	Moreover	moreover	RB
cord-334907-l4jjb93l	226	2	,	,	,
cord-334907-l4jjb93l	226	3	treatment	treatment	NN
cord-334907-l4jjb93l	226	4	of	of	IN
cord-334907-l4jjb93l	226	5	ASK	ask	NN
cord-334907-l4jjb93l	226	6	cells	cell	NNS
cord-334907-l4jjb93l	226	7	with	with	IN
cord-334907-l4jjb93l	226	8	a	a	DT
cord-334907-l4jjb93l	226	9	combination	combination	NN
cord-334907-l4jjb93l	226	10	of	of	IN
cord-334907-l4jjb93l	226	11	both	both	DT
cord-334907-l4jjb93l	226	12	lectins	lectin	NNS
cord-334907-l4jjb93l	226	13	resulted	result	VBD
cord-334907-l4jjb93l	226	14	in	in	IN
cord-334907-l4jjb93l	226	15	the	the	DT
cord-334907-l4jjb93l	226	16	highest	high	JJS
cord-334907-l4jjb93l	226	17	inhibition	inhibition	NN
cord-334907-l4jjb93l	226	18	of	of	IN
cord-334907-l4jjb93l	226	19	viral	viral	JJ
cord-334907-l4jjb93l	226	20	gene	gene	NN
cord-334907-l4jjb93l	226	21	expression	expression	NN
cord-334907-l4jjb93l	226	22	/	/	SYM
cord-334907-l4jjb93l	226	23	ISAV	ISAV	NNP
cord-334907-l4jjb93l	226	24	infection	infection	NN
cord-334907-l4jjb93l	226	25	,	,	,
cord-334907-l4jjb93l	226	26	with	with	IN
cord-334907-l4jjb93l	226	27	significant	significant	JJ
cord-334907-l4jjb93l	226	28	differences	difference	NNS
cord-334907-l4jjb93l	226	29	from	from	IN
cord-334907-l4jjb93l	226	30	the	the	DT
cord-334907-l4jjb93l	226	31	single	single	JJ
cord-334907-l4jjb93l	226	32	-	-	HYPH
cord-334907-l4jjb93l	226	33	lectin	lectin	NN
cord-334907-l4jjb93l	226	34	-	-	HYPH
cord-334907-l4jjb93l	226	35	treated	treat	VBN
cord-334907-l4jjb93l	226	36	cells	cell	NNS
cord-334907-l4jjb93l	226	37	;	;	:
cord-334907-l4jjb93l	226	38	accordingly	accordingly	RB
cord-334907-l4jjb93l	226	39	,	,	,
cord-334907-l4jjb93l	226	40	the	the	DT
cord-334907-l4jjb93l	226	41	result	result	NN
cord-334907-l4jjb93l	226	42	suggests	suggest	VBZ
cord-334907-l4jjb93l	226	43	the	the	DT
cord-334907-l4jjb93l	226	44	existence	existence	NN
cord-334907-l4jjb93l	226	45	of	of	IN
cord-334907-l4jjb93l	226	46	independent	independent	JJ
cord-334907-l4jjb93l	226	47	receptors	receptor	NNS
cord-334907-l4jjb93l	226	48	for	for	IN
cord-334907-l4jjb93l	226	49	HE	HE	NNP
cord-334907-l4jjb93l	226	50	and	and	CC
cord-334907-l4jjb93l	226	51	F	F	NNP
cord-334907-l4jjb93l	226	52	,	,	,
cord-334907-l4jjb93l	226	53	manifested	manifest	VBD
cord-334907-l4jjb93l	226	54	in	in	IN
cord-334907-l4jjb93l	226	55	an	an	DT
cord-334907-l4jjb93l	226	56	additive	additive	NN
cord-334907-l4jjb93l	226	57	effect	effect	NN
cord-334907-l4jjb93l	226	58	for	for	IN
cord-334907-l4jjb93l	226	59	the	the	DT
cord-334907-l4jjb93l	226	60	inhibition	inhibition	NN
cord-334907-l4jjb93l	226	61	,	,	,
cord-334907-l4jjb93l	226	62	and	and	CC
cord-334907-l4jjb93l	226	63	confirms	confirm	VBZ
cord-334907-l4jjb93l	226	64	the	the	DT
cord-334907-l4jjb93l	226	65	importance	importance	NN
cord-334907-l4jjb93l	226	66	of	of	IN
cord-334907-l4jjb93l	226	67	the	the	DT
cord-334907-l4jjb93l	226	68	interaction	interaction	NN
cord-334907-l4jjb93l	226	69	of	of	IN
cord-334907-l4jjb93l	226	70	both	both	DT
cord-334907-l4jjb93l	226	71	proteins	protein	NNS
cord-334907-l4jjb93l	226	72	with	with	IN
cord-334907-l4jjb93l	226	73	the	the	DT
cord-334907-l4jjb93l	226	74	cell	cell	NN
cord-334907-l4jjb93l	226	75	surface	surface	NN
cord-334907-l4jjb93l	226	76	for	for	IN
cord-334907-l4jjb93l	226	77	the	the	DT
cord-334907-l4jjb93l	226	78	infective	infective	JJ
cord-334907-l4jjb93l	226	79	process	process	NN
cord-334907-l4jjb93l	226	80	.	.	.
cord-334907-l4jjb93l	227	1	As	as	IN
cord-334907-l4jjb93l	227	2	previously	previously	RB
cord-334907-l4jjb93l	227	3	reported	report	VBN
cord-334907-l4jjb93l	227	4	,	,	,
cord-334907-l4jjb93l	227	5	membrane	membrane	NN
cord-334907-l4jjb93l	227	6	fusion	fusion	NN
cord-334907-l4jjb93l	227	7	assays	assay	NNS
cord-334907-l4jjb93l	227	8	revealed	reveal	VBD
cord-334907-l4jjb93l	227	9	a	a	DT
cord-334907-l4jjb93l	227	10	lower	low	JJR
cord-334907-l4jjb93l	227	11	fusion	fusion	NN
cord-334907-l4jjb93l	227	12	activity	activity	NN
cord-334907-l4jjb93l	227	13	in	in	IN
cord-334907-l4jjb93l	227	14	the	the	DT
cord-334907-l4jjb93l	227	15	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	227	16	system	system	NN
cord-334907-l4jjb93l	227	17	,	,	,
cord-334907-l4jjb93l	227	18	compared	compare	VBN
cord-334907-l4jjb93l	227	19	to	to	IN
cord-334907-l4jjb93l	227	20	a	a	DT
cord-334907-l4jjb93l	227	21	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	227	22	(	(	-LRB-
cord-334907-l4jjb93l	227	23	Figure	figure	NN
cord-334907-l4jjb93l	227	24	5a	5a	CD
cord-334907-l4jjb93l	227	25	)	)	-RRB-
cord-334907-l4jjb93l	227	26	[	[	-LRB-
cord-334907-l4jjb93l	227	27	19	19	CD
cord-334907-l4jjb93l	227	28	]	]	-RRB-
cord-334907-l4jjb93l	227	29	.	.	.
cord-334907-l4jjb93l	228	1	Similarly	similarly	RB
cord-334907-l4jjb93l	228	2	,	,	,
cord-334907-l4jjb93l	228	3	we	-PRON-	PRP
cord-334907-l4jjb93l	228	4	used	use	VBD
cord-334907-l4jjb93l	228	5	this	this	DT
cord-334907-l4jjb93l	228	6	approach	approach	NN
cord-334907-l4jjb93l	228	7	to	to	TO
cord-334907-l4jjb93l	228	8	evaluate	evaluate	VB
cord-334907-l4jjb93l	228	9	the	the	DT
cord-334907-l4jjb93l	228	10	role	role	NN
cord-334907-l4jjb93l	228	11	of	of	IN
cord-334907-l4jjb93l	228	12	the	the	DT
cord-334907-l4jjb93l	228	13	F	F	NNP
cord-334907-l4jjb93l	228	14	1	1	CD
cord-334907-l4jjb93l	228	15	domain	domain	NN
cord-334907-l4jjb93l	228	16	in	in	IN
cord-334907-l4jjb93l	228	17	the	the	DT
cord-334907-l4jjb93l	228	18	fusion	fusion	NN
cord-334907-l4jjb93l	228	19	mechanism	mechanism	NN
cord-334907-l4jjb93l	228	20	.	.	.
cord-334907-l4jjb93l	229	1	In	in	IN
cord-334907-l4jjb93l	229	2	particular	particular	JJ
cord-334907-l4jjb93l	229	3	,	,	,
cord-334907-l4jjb93l	229	4	the	the	DT
cord-334907-l4jjb93l	229	5	importance	importance	NN
cord-334907-l4jjb93l	229	6	of	of	IN
cord-334907-l4jjb93l	229	7	the	the	DT
cord-334907-l4jjb93l	229	8	aforementioned	aforementioned	JJ
cord-334907-l4jjb93l	229	9	phenylalanine	phenylalanine	NN
cord-334907-l4jjb93l	229	10	residues	residue	NNS
cord-334907-l4jjb93l	229	11	in	in	IN
cord-334907-l4jjb93l	229	12	the	the	DT
cord-334907-l4jjb93l	229	13	F	F	NNP
cord-334907-l4jjb93l	229	14	1	1	CD
cord-334907-l4jjb93l	229	15	LB	LB	NNP
cord-334907-l4jjb93l	229	16	was	be	VBD
cord-334907-l4jjb93l	229	17	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	229	18	by	by	IN
cord-334907-l4jjb93l	229	19	the	the	DT
cord-334907-l4jjb93l	229	20	Phe183Ile	Phe183Ile	NNP
cord-334907-l4jjb93l	229	21	and	and	CC
cord-334907-l4jjb93l	229	22	Phe227Ile	Phe227Ile	NNP
cord-334907-l4jjb93l	229	23	mutations	mutation	NNS
cord-334907-l4jjb93l	229	24	,	,	,
cord-334907-l4jjb93l	229	25	with	with	IN
cord-334907-l4jjb93l	229	26	the	the	DT
cord-334907-l4jjb93l	229	27	system	system	NN
cord-334907-l4jjb93l	229	28	showing	show	VBG
cord-334907-l4jjb93l	229	29	a	a	DT
cord-334907-l4jjb93l	229	30	reduction	reduction	NN
cord-334907-l4jjb93l	229	31	in	in	IN
cord-334907-l4jjb93l	229	32	activity	activity	NN
cord-334907-l4jjb93l	229	33	to	to	IN
cord-334907-l4jjb93l	229	34	7.1	7.1	CD
cord-334907-l4jjb93l	229	35	%	%	NN
cord-334907-l4jjb93l	229	36	and	and	CC
cord-334907-l4jjb93l	229	37	43.7	43.7	CD
cord-334907-l4jjb93l	229	38	%	%	NN
cord-334907-l4jjb93l	229	39	,	,	,
cord-334907-l4jjb93l	229	40	respectively	respectively	RB
cord-334907-l4jjb93l	229	41	,	,	,
cord-334907-l4jjb93l	229	42	compared	compare	VBN
cord-334907-l4jjb93l	229	43	to	to	IN
cord-334907-l4jjb93l	229	44	the	the	DT
cord-334907-l4jjb93l	229	45	control	control	NN
cord-334907-l4jjb93l	229	46	(	(	-LRB-
cord-334907-l4jjb93l	229	47	Figure	figure	NN
cord-334907-l4jjb93l	229	48	5b	5b	CD
cord-334907-l4jjb93l	229	49	)	)	-RRB-
cord-334907-l4jjb93l	229	50	.	.	.
cord-334907-l4jjb93l	230	1	Moreover	moreover	RB
cord-334907-l4jjb93l	230	2	,	,	,
cord-334907-l4jjb93l	230	3	the	the	DT
cord-334907-l4jjb93l	230	4	double	double	JJ
cord-334907-l4jjb93l	230	5	mutant	mutant	NN
cord-334907-l4jjb93l	230	6	abolished	abolish	VBD
cord-334907-l4jjb93l	230	7	all	all	DT
cord-334907-l4jjb93l	230	8	fusion	fusion	NN
cord-334907-l4jjb93l	230	9	activity	activity	NN
cord-334907-l4jjb93l	230	10	,	,	,
cord-334907-l4jjb93l	230	11	proving	prove	VBG
cord-334907-l4jjb93l	230	12	the	the	DT
cord-334907-l4jjb93l	230	13	importance	importance	NN
cord-334907-l4jjb93l	230	14	of	of	IN
cord-334907-l4jjb93l	230	15	these	these	DT
cord-334907-l4jjb93l	230	16	residues	residue	NNS
cord-334907-l4jjb93l	230	17	for	for	IN
cord-334907-l4jjb93l	230	18	the	the	DT
cord-334907-l4jjb93l	230	19	mechanism	mechanism	NN
cord-334907-l4jjb93l	230	20	and	and	CC
cord-334907-l4jjb93l	230	21	a	a	DT
cord-334907-l4jjb93l	230	22	putative	putative	JJ
cord-334907-l4jjb93l	230	23	interaction	interaction	NN
cord-334907-l4jjb93l	230	24	of	of	IN
cord-334907-l4jjb93l	230	25	F	F	NNP
cord-334907-l4jjb93l	230	26	1	1	CD
cord-334907-l4jjb93l	230	27	with	with	IN
cord-334907-l4jjb93l	230	28	a	a	DT
cord-334907-l4jjb93l	230	29	cell	cell	NN
cord-334907-l4jjb93l	230	30	receptor	receptor	NN
cord-334907-l4jjb93l	230	31	.	.	.
cord-334907-l4jjb93l	231	1	Both	both	DT
cord-334907-l4jjb93l	231	2	Phe	Phe	NNP
cord-334907-l4jjb93l	231	3	residues	residue	NNS
cord-334907-l4jjb93l	231	4	are	be	VBP
cord-334907-l4jjb93l	231	5	highly	highly	RB
cord-334907-l4jjb93l	231	6	conserved	conserve	VBN
cord-334907-l4jjb93l	231	7	amongst	amongst	IN
cord-334907-l4jjb93l	231	8	ISAV	ISAV	NNP
cord-334907-l4jjb93l	231	9	F	F	NNP
cord-334907-l4jjb93l	231	10	sequences	sequence	NNS
cord-334907-l4jjb93l	231	11	reported	report	VBN
cord-334907-l4jjb93l	231	12	in	in	IN
cord-334907-l4jjb93l	231	13	GenBank	GenBank	NNP
cord-334907-l4jjb93l	231	14	,	,	,
cord-334907-l4jjb93l	231	15	with	with	IN
cord-334907-l4jjb93l	231	16	only	only	RB
cord-334907-l4jjb93l	231	17	4	4	CD
cord-334907-l4jjb93l	231	18	%	%	NN
cord-334907-l4jjb93l	231	19	of	of	IN
cord-334907-l4jjb93l	231	20	them	-PRON-	PRP
cord-334907-l4jjb93l	231	21	showing	show	VBG
cord-334907-l4jjb93l	231	22	a	a	DT
cord-334907-l4jjb93l	231	23	Phe183Leu	Phe183Leu	NNP
cord-334907-l4jjb93l	231	24	change	change	NN
cord-334907-l4jjb93l	231	25	(	(	-LRB-
cord-334907-l4jjb93l	231	26	data	datum	NNS
cord-334907-l4jjb93l	231	27	not	not	RB
cord-334907-l4jjb93l	231	28	shown	show	VBN
cord-334907-l4jjb93l	231	29	)	)	-RRB-
cord-334907-l4jjb93l	231	30	,	,	,
cord-334907-l4jjb93l	231	31	which	which	WDT
cord-334907-l4jjb93l	231	32	correlates	correlate	VBZ
cord-334907-l4jjb93l	231	33	with	with	IN
cord-334907-l4jjb93l	231	34	the	the	DT
cord-334907-l4jjb93l	231	35	importance	importance	NN
cord-334907-l4jjb93l	231	36	of	of	IN
cord-334907-l4jjb93l	231	37	their	-PRON-	PRP$
cord-334907-l4jjb93l	231	38	function	function	NN
cord-334907-l4jjb93l	231	39	,	,	,
cord-334907-l4jjb93l	231	40	as	as	IN
cord-334907-l4jjb93l	231	41	proven	prove	VBN
cord-334907-l4jjb93l	231	42	by	by	IN
cord-334907-l4jjb93l	231	43	these	these	DT
cord-334907-l4jjb93l	231	44	results	result	NNS
cord-334907-l4jjb93l	231	45	.	.	.
cord-334907-l4jjb93l	232	1	We	-PRON-	PRP
cord-334907-l4jjb93l	232	2	suggest	suggest	VBP
cord-334907-l4jjb93l	232	3	an	an	DT
cord-334907-l4jjb93l	232	4	influence	influence	NN
cord-334907-l4jjb93l	232	5	of	of	IN
cord-334907-l4jjb93l	232	6	the	the	DT
cord-334907-l4jjb93l	232	7	HPR	HPR	NNP
cord-334907-l4jjb93l	232	8	over	over	IN
cord-334907-l4jjb93l	232	9	the	the	DT
cord-334907-l4jjb93l	232	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	232	11	HE	HE	NNP
cord-334907-l4jjb93l	232	12	esterase	esterase	NN
cord-334907-l4jjb93l	232	13	activity	activity	NN
cord-334907-l4jjb93l	232	14	,	,	,
cord-334907-l4jjb93l	232	15	considering	consider	VBG
cord-334907-l4jjb93l	232	16	the	the	DT
cord-334907-l4jjb93l	232	17	results	result	NNS
cord-334907-l4jjb93l	232	18	previously	previously	RB
cord-334907-l4jjb93l	232	19	reported	report	VBD
cord-334907-l4jjb93l	232	20	for	for	IN
cord-334907-l4jjb93l	232	21	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	232	22	with	with	IN
cord-334907-l4jjb93l	232	23	rabbit	rabbit	NN
cord-334907-l4jjb93l	232	24	RBCs	rbc	NNS
cord-334907-l4jjb93l	232	25	,	,	,
cord-334907-l4jjb93l	232	26	and	and	CC
cord-334907-l4jjb93l	232	27	that	that	IN
cord-334907-l4jjb93l	232	28	this	this	DT
cord-334907-l4jjb93l	232	29	activity	activity	NN
cord-334907-l4jjb93l	232	30	may	may	MD
cord-334907-l4jjb93l	232	31	influence	influence	VB
cord-334907-l4jjb93l	232	32	the	the	DT
cord-334907-l4jjb93l	232	33	interaction	interaction	NN
cord-334907-l4jjb93l	232	34	of	of	IN
cord-334907-l4jjb93l	232	35	F	F	NNP
cord-334907-l4jjb93l	232	36	with	with	IN
cord-334907-l4jjb93l	232	37	its	-PRON-	PRP$
cord-334907-l4jjb93l	232	38	cell	cell	NN
cord-334907-l4jjb93l	232	39	receptor	receptor	NN
cord-334907-l4jjb93l	232	40	[	[	-LRB-
cord-334907-l4jjb93l	232	41	18	18	CD
cord-334907-l4jjb93l	232	42	]	]	-RRB-
cord-334907-l4jjb93l	232	43	.	.	.
cord-334907-l4jjb93l	233	1	Indeed	indeed	RB
cord-334907-l4jjb93l	233	2	,	,	,
cord-334907-l4jjb93l	233	3	fusion	fusion	NN
cord-334907-l4jjb93l	233	4	assays	assay	NNS
cord-334907-l4jjb93l	233	5	using	use	VBG
cord-334907-l4jjb93l	233	6	a	a	DT
cord-334907-l4jjb93l	233	7	Ser32Ala	ser32ala	NN
cord-334907-l4jjb93l	233	8	mutated	mutate	VBN
cord-334907-l4jjb93l	233	9	version	version	NN
cord-334907-l4jjb93l	233	10	of	of	IN
cord-334907-l4jjb93l	233	11	HPR0	HPR0	NNP
cord-334907-l4jjb93l	234	1	HE	he	PRP
cord-334907-l4jjb93l	234	2	showed	show	VBD
cord-334907-l4jjb93l	234	3	an	an	DT
cord-334907-l4jjb93l	234	4	increased	increase	VBN
cord-334907-l4jjb93l	234	5	fusion	fusion	NN
cord-334907-l4jjb93l	234	6	activity	activity	NN
cord-334907-l4jjb93l	234	7	compared	compare	VBN
cord-334907-l4jjb93l	234	8	to	to	IN
cord-334907-l4jjb93l	234	9	the	the	DT
cord-334907-l4jjb93l	234	10	WT	WT	NNP
cord-334907-l4jjb93l	234	11	HPR0	HPR0	NNP
cord-334907-l4jjb93l	234	12	HE	HE	NNP
cord-334907-l4jjb93l	234	13	,	,	,
cord-334907-l4jjb93l	234	14	demonstrating	demonstrate	VBG
cord-334907-l4jjb93l	234	15	a	a	DT
cord-334907-l4jjb93l	234	16	negative	negative	JJ
cord-334907-l4jjb93l	234	17	influence	influence	NN
cord-334907-l4jjb93l	234	18	of	of	IN
cord-334907-l4jjb93l	234	19	the	the	DT
cord-334907-l4jjb93l	234	20	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	234	21	activity	activity	NN
cord-334907-l4jjb93l	234	22	over	over	IN
cord-334907-l4jjb93l	234	23	the	the	DT
cord-334907-l4jjb93l	234	24	fusion	fusion	NN
cord-334907-l4jjb93l	234	25	mechanism	mechanism	NN
cord-334907-l4jjb93l	234	26	.	.	.
cord-334907-l4jjb93l	235	1	For	for	IN
cord-334907-l4jjb93l	235	2	the	the	DT
cord-334907-l4jjb93l	235	3	esterase	esterase	NN
cord-334907-l4jjb93l	235	4	inactive	inactive	JJ
cord-334907-l4jjb93l	235	5	mutant	mutant	JJ
cord-334907-l4jjb93l	235	6	,	,	,
cord-334907-l4jjb93l	235	7	membrane	membrane	NN
cord-334907-l4jjb93l	235	8	fusion	fusion	NN
cord-334907-l4jjb93l	235	9	activity	activity	NN
cord-334907-l4jjb93l	235	10	reached	reach	VBD
cord-334907-l4jjb93l	235	11	up	up	RB
cord-334907-l4jjb93l	235	12	to	to	TO
cord-334907-l4jjb93l	235	13	40	40	CD
cord-334907-l4jjb93l	235	14	%	%	NN
cord-334907-l4jjb93l	235	15	(	(	-LRB-
cord-334907-l4jjb93l	235	16	Figure	figure	NN
cord-334907-l4jjb93l	235	17	5c	5c	CD
cord-334907-l4jjb93l	235	18	)	)	-RRB-
cord-334907-l4jjb93l	235	19	.	.	.
cord-334907-l4jjb93l	236	1	These	these	DT
cord-334907-l4jjb93l	236	2	results	result	NNS
cord-334907-l4jjb93l	236	3	coincide	coincide	VBP
cord-334907-l4jjb93l	236	4	with	with	IN
cord-334907-l4jjb93l	236	5	the	the	DT
cord-334907-l4jjb93l	236	6	rHE	rhe	NN
cord-334907-l4jjb93l	236	7	-	-	HYPH
cord-334907-l4jjb93l	236	8	mediated	mediate	VBN
cord-334907-l4jjb93l	236	9	impairment	impairment	NN
cord-334907-l4jjb93l	236	10	of	of	IN
cord-334907-l4jjb93l	236	11	the	the	DT
cord-334907-l4jjb93l	236	12	rF	rf	NN
cord-334907-l4jjb93l	236	13	interaction	interaction	NN
cord-334907-l4jjb93l	236	14	with	with	IN
cord-334907-l4jjb93l	236	15	the	the	DT
cord-334907-l4jjb93l	236	16	cell	cell	NN
cord-334907-l4jjb93l	236	17	and	and	CC
cord-334907-l4jjb93l	236	18	the	the	DT
cord-334907-l4jjb93l	236	19	recovery	recovery	NN
cord-334907-l4jjb93l	236	20	of	of	IN
cord-334907-l4jjb93l	236	21	such	such	JJ
cord-334907-l4jjb93l	236	22	interaction	interaction	NN
cord-334907-l4jjb93l	236	23	with	with	IN
cord-334907-l4jjb93l	236	24	the	the	DT
cord-334907-l4jjb93l	236	25	DCIC	DCIC	NNP
cord-334907-l4jjb93l	236	26	treatment	treatment	NN
cord-334907-l4jjb93l	236	27	(	(	-LRB-
cord-334907-l4jjb93l	236	28	Figure	figure	NN
cord-334907-l4jjb93l	236	29	3	3	CD
cord-334907-l4jjb93l	236	30	)	)	-RRB-
cord-334907-l4jjb93l	236	31	,	,	,
cord-334907-l4jjb93l	236	32	reinforcing	reinforce	VBG
cord-334907-l4jjb93l	236	33	the	the	DT
cord-334907-l4jjb93l	236	34	hypothesis	hypothesis	NN
cord-334907-l4jjb93l	236	35	of	of	IN
cord-334907-l4jjb93l	236	36	a	a	DT
cord-334907-l4jjb93l	236	37	direct	direct	JJ
cord-334907-l4jjb93l	236	38	relation	relation	NN
cord-334907-l4jjb93l	236	39	of	of	IN
cord-334907-l4jjb93l	236	40	F	F	NNP
cord-334907-l4jjb93l	236	41	with	with	IN
cord-334907-l4jjb93l	236	42	a	a	DT
cord-334907-l4jjb93l	236	43	sialic	sialic	JJ
cord-334907-l4jjb93l	236	44	acid	acid	NN
cord-334907-l4jjb93l	236	45	on	on	IN
cord-334907-l4jjb93l	236	46	the	the	DT
cord-334907-l4jjb93l	236	47	cell	cell	NN
cord-334907-l4jjb93l	236	48	surface	surface	NN
cord-334907-l4jjb93l	236	49	and	and	CC
cord-334907-l4jjb93l	236	50	the	the	DT
cord-334907-l4jjb93l	236	51	importance	importance	NN
cord-334907-l4jjb93l	236	52	of	of	IN
cord-334907-l4jjb93l	236	53	this	this	DT
cord-334907-l4jjb93l	236	54	event	event	NN
cord-334907-l4jjb93l	236	55	for	for	IN
cord-334907-l4jjb93l	236	56	the	the	DT
cord-334907-l4jjb93l	236	57	activation	activation	NN
cord-334907-l4jjb93l	236	58	of	of	IN
cord-334907-l4jjb93l	236	59	the	the	DT
cord-334907-l4jjb93l	236	60	fusion	fusion	NN
cord-334907-l4jjb93l	236	61	mechanism	mechanism	NN
cord-334907-l4jjb93l	236	62	.	.	.
cord-334907-l4jjb93l	237	1	We	-PRON-	PRP
cord-334907-l4jjb93l	237	2	hypothesize	hypothesize	VBP
cord-334907-l4jjb93l	237	3	that	that	IN
cord-334907-l4jjb93l	237	4	the	the	DT
cord-334907-l4jjb93l	237	5	combined	combine	VBN
cord-334907-l4jjb93l	237	6	roles	role	NNS
cord-334907-l4jjb93l	237	7	of	of	IN
cord-334907-l4jjb93l	237	8	HE	HE	NNP
cord-334907-l4jjb93l	237	9	and	and	CC
cord-334907-l4jjb93l	237	10	F	F	NNP
cord-334907-l4jjb93l	237	11	define	define	VBP
cord-334907-l4jjb93l	237	12	the	the	DT
cord-334907-l4jjb93l	237	13	fusion	fusion	NN
cord-334907-l4jjb93l	237	14	activity	activity	NN
cord-334907-l4jjb93l	237	15	of	of	IN
cord-334907-l4jjb93l	237	16	the	the	DT
cord-334907-l4jjb93l	237	17	viral	viral	JJ
cord-334907-l4jjb93l	237	18	particle	particle	NN
cord-334907-l4jjb93l	237	19	,	,	,
cord-334907-l4jjb93l	237	20	where	where	WRB
cord-334907-l4jjb93l	237	21	synergistic	synergistic	JJ
cord-334907-l4jjb93l	237	22	effects	effect	NNS
cord-334907-l4jjb93l	237	23	modulate	modulate	VBP
cord-334907-l4jjb93l	237	24	this	this	DT
cord-334907-l4jjb93l	237	25	mechanism	mechanism	NN
cord-334907-l4jjb93l	237	26	,	,	,
cord-334907-l4jjb93l	237	27	to	to	TO
cord-334907-l4jjb93l	237	28	optimize	optimize	VB
cord-334907-l4jjb93l	237	29	viral	viral	JJ
cord-334907-l4jjb93l	237	30	replication	replication	NN
cord-334907-l4jjb93l	237	31	.	.	.
cord-334907-l4jjb93l	238	1	Interestingly	interestingly	RB
cord-334907-l4jjb93l	238	2	,	,	,
cord-334907-l4jjb93l	238	3	even	even	RB
cord-334907-l4jjb93l	238	4	though	though	IN
cord-334907-l4jjb93l	238	5	salmon	salmon	NN
cord-334907-l4jjb93l	238	6	RBCs	rbc	NNS
cord-334907-l4jjb93l	238	7	are	be	VBP
cord-334907-l4jjb93l	238	8	effectively	effectively	RB
cord-334907-l4jjb93l	238	9	(	(	-LRB-
cord-334907-l4jjb93l	238	10	and	and	CC
cord-334907-l4jjb93l	238	11	irreversibly	irreversibly	RB
cord-334907-l4jjb93l	238	12	)	)	-RRB-
cord-334907-l4jjb93l	238	13	agglutinated	agglutinate	VBN
cord-334907-l4jjb93l	238	14	by	by	IN
cord-334907-l4jjb93l	238	15	ISAV	ISAV	NNP
cord-334907-l4jjb93l	238	16	HE	HE	NNP
cord-334907-l4jjb93l	238	17	and	and	CC
cord-334907-l4jjb93l	238	18	are	be	VBP
cord-334907-l4jjb93l	238	19	capable	capable	JJ
cord-334907-l4jjb93l	238	20	of	of	IN
cord-334907-l4jjb93l	238	21	endocytosis	endocytosis	NN
cord-334907-l4jjb93l	238	22	,	,	,
cord-334907-l4jjb93l	238	23	effective	effective	JJ
cord-334907-l4jjb93l	238	24	replication	replication	NN
cord-334907-l4jjb93l	238	25	of	of	IN
cord-334907-l4jjb93l	238	26	ISAV	ISAV	NNP
cord-334907-l4jjb93l	238	27	on	on	IN
cord-334907-l4jjb93l	238	28	these	these	DT
cord-334907-l4jjb93l	238	29	cells	cell	NNS
cord-334907-l4jjb93l	238	30	has	have	VBZ
cord-334907-l4jjb93l	238	31	not	not	RB
cord-334907-l4jjb93l	238	32	been	be	VBN
cord-334907-l4jjb93l	238	33	confirmed	confirm	VBN
cord-334907-l4jjb93l	238	34	,	,	,
cord-334907-l4jjb93l	238	35	and	and	CC
cord-334907-l4jjb93l	238	36	they	-PRON-	PRP
cord-334907-l4jjb93l	238	37	are	be	VBP
cord-334907-l4jjb93l	238	38	regarded	regard	VBN
cord-334907-l4jjb93l	238	39	as	as	IN
cord-334907-l4jjb93l	238	40	poor	poor	JJ
cord-334907-l4jjb93l	238	41	viral	viral	JJ
cord-334907-l4jjb93l	238	42	factories	factory	NNS
cord-334907-l4jjb93l	238	43	for	for	IN
cord-334907-l4jjb93l	238	44	other	other	JJ
cord-334907-l4jjb93l	238	45	piscine	piscine	JJ
cord-334907-l4jjb93l	238	46	viruses	virus	NNS
cord-334907-l4jjb93l	238	47	[	[	-LRB-
cord-334907-l4jjb93l	238	48	27	27	CD
cord-334907-l4jjb93l	238	49	,	,	,
cord-334907-l4jjb93l	238	50	[	[	-LRB-
cord-334907-l4jjb93l	238	51	46	46	CD
cord-334907-l4jjb93l	238	52	]	]	-RRB-
cord-334907-l4jjb93l	239	1	[	[	-LRB-
cord-334907-l4jjb93l	239	2	47	47	CD
cord-334907-l4jjb93l	239	3	]	]	-RRB-
cord-334907-l4jjb93l	240	1	[	[	-LRB-
cord-334907-l4jjb93l	240	2	48	48	CD
cord-334907-l4jjb93l	240	3	]	]	-RRB-
cord-334907-l4jjb93l	240	4	[	[	-LRB-
cord-334907-l4jjb93l	240	5	49	49	CD
cord-334907-l4jjb93l	240	6	]	]	-RRB-
cord-334907-l4jjb93l	240	7	.	.	.
cord-334907-l4jjb93l	241	1	In	in	IN
cord-334907-l4jjb93l	241	2	this	this	DT
cord-334907-l4jjb93l	241	3	context	context	NN
cord-334907-l4jjb93l	241	4	,	,	,
cord-334907-l4jjb93l	241	5	the	the	DT
cord-334907-l4jjb93l	241	6	virus	virus	NN
cord-334907-l4jjb93l	241	7	may	may	MD
cord-334907-l4jjb93l	241	8	"	"	``
cord-334907-l4jjb93l	241	9	select	select	VB
cord-334907-l4jjb93l	241	10	"	"	''
cord-334907-l4jjb93l	241	11	an	an	DT
cord-334907-l4jjb93l	241	12	appropriate	appropriate	JJ
cord-334907-l4jjb93l	241	13	cell	cell	NN
cord-334907-l4jjb93l	241	14	target	target	NN
cord-334907-l4jjb93l	241	15	,	,	,
cord-334907-l4jjb93l	241	16	using	use	VBG
cord-334907-l4jjb93l	241	17	a	a	DT
cord-334907-l4jjb93l	241	18	secondary	secondary	JJ
cord-334907-l4jjb93l	241	19	receptor	receptor	NN
cord-334907-l4jjb93l	241	20	(	(	-LRB-
cord-334907-l4jjb93l	241	21	i.e.	i.e.	FW
cord-334907-l4jjb93l	241	22	,	,	,
cord-334907-l4jjb93l	241	23	an	an	DT
cord-334907-l4jjb93l	241	24	F	F	NNP
cord-334907-l4jjb93l	241	25	receptor	receptor	NN
cord-334907-l4jjb93l	241	26	)	)	-RRB-
cord-334907-l4jjb93l	241	27	,	,	,
cord-334907-l4jjb93l	241	28	independent	independent	JJ
cord-334907-l4jjb93l	241	29	of	of	IN
cord-334907-l4jjb93l	241	30	HE	HE	NNP
cord-334907-l4jjb93l	241	31	.	.	.
cord-334907-l4jjb93l	242	1	Thus	thus	RB
cord-334907-l4jjb93l	242	2	,	,	,
cord-334907-l4jjb93l	242	3	the	the	DT
cord-334907-l4jjb93l	242	4	interaction	interaction	NN
cord-334907-l4jjb93l	242	5	of	of	IN
cord-334907-l4jjb93l	242	6	HE	he	PRP
cord-334907-l4jjb93l	242	7	with	with	IN
cord-334907-l4jjb93l	242	8	its	-PRON-	PRP$
cord-334907-l4jjb93l	242	9	receptor	receptor	NN
cord-334907-l4jjb93l	242	10	,	,	,
cord-334907-l4jjb93l	242	11	as	as	IN
cord-334907-l4jjb93l	242	12	proved	prove	VBN
cord-334907-l4jjb93l	242	13	by	by	IN
cord-334907-l4jjb93l	242	14	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	242	15	and	and	CC
cord-334907-l4jjb93l	242	16	hemagglutination	hemagglutination	NN
cord-334907-l4jjb93l	242	17	,	,	,
cord-334907-l4jjb93l	242	18	does	do	VBZ
cord-334907-l4jjb93l	242	19	not	not	RB
cord-334907-l4jjb93l	242	20	suffice	suffice	VB
cord-334907-l4jjb93l	242	21	for	for	IN
cord-334907-l4jjb93l	242	22	the	the	DT
cord-334907-l4jjb93l	242	23	correct	correct	JJ
cord-334907-l4jjb93l	242	24	activation	activation	NN
cord-334907-l4jjb93l	242	25	of	of	IN
cord-334907-l4jjb93l	242	26	the	the	DT
cord-334907-l4jjb93l	242	27	membrane	membrane	NN
cord-334907-l4jjb93l	242	28	fusion	fusion	NN
cord-334907-l4jjb93l	242	29	mechanism	mechanism	NN
cord-334907-l4jjb93l	242	30	and	and	CC
cord-334907-l4jjb93l	242	31	cell	cell	NN
cord-334907-l4jjb93l	242	32	infection	infection	NN
cord-334907-l4jjb93l	242	33	.	.	.
cord-334907-l4jjb93l	243	1	Finally	finally	RB
cord-334907-l4jjb93l	243	2	,	,	,
cord-334907-l4jjb93l	243	3	a	a	DT
cord-334907-l4jjb93l	243	4	particular	particular	JJ
cord-334907-l4jjb93l	243	5	tropism	tropism	NN
cord-334907-l4jjb93l	243	6	may	may	MD
cord-334907-l4jjb93l	243	7	be	be	VB
cord-334907-l4jjb93l	243	8	related	relate	VBN
cord-334907-l4jjb93l	243	9	to	to	IN
cord-334907-l4jjb93l	243	10	the	the	DT
cord-334907-l4jjb93l	243	11	HPR0	HPR0	NNP
cord-334907-l4jjb93l	243	12	behavior	behavior	NN
cord-334907-l4jjb93l	243	13	,	,	,
cord-334907-l4jjb93l	243	14	where	where	WRB
cord-334907-l4jjb93l	243	15	specific	specific	JJ
cord-334907-l4jjb93l	243	16	cells	cell	NNS
cord-334907-l4jjb93l	243	17	on	on	IN
cord-334907-l4jjb93l	243	18	the	the	DT
cord-334907-l4jjb93l	243	19	fish	fish	NN
cord-334907-l4jjb93l	243	20	support	support	NN
cord-334907-l4jjb93l	243	21	viral	viral	JJ
cord-334907-l4jjb93l	243	22	replication	replication	NN
cord-334907-l4jjb93l	243	23	for	for	IN
cord-334907-l4jjb93l	243	24	the	the	DT
cord-334907-l4jjb93l	243	25	strain	strain	NN
cord-334907-l4jjb93l	243	26	(	(	-LRB-
cord-334907-l4jjb93l	243	27	i.e.	i.e.	FW
cord-334907-l4jjb93l	243	28	,	,	,
cord-334907-l4jjb93l	243	29	with	with	IN
cord-334907-l4jjb93l	243	30	high	high	JJ
cord-334907-l4jjb93l	243	31	content	content	NN
cord-334907-l4jjb93l	243	32	or	or	CC
cord-334907-l4jjb93l	243	33	high	high	JJ
cord-334907-l4jjb93l	243	34	exposure	exposure	NN
cord-334907-l4jjb93l	243	35	of	of	IN
cord-334907-l4jjb93l	243	36	the	the	DT
cord-334907-l4jjb93l	243	37	F	F	NNP
cord-334907-l4jjb93l	243	38	receptor	receptor	NN
cord-334907-l4jjb93l	243	39	)	)	-RRB-
cord-334907-l4jjb93l	243	40	at	at	IN
cord-334907-l4jjb93l	243	41	low	low	JJ
cord-334907-l4jjb93l	243	42	rate	rate	NN
cord-334907-l4jjb93l	243	43	and	and	CC
cord-334907-l4jjb93l	243	44	with	with	IN
cord-334907-l4jjb93l	243	45	no	no	DT
cord-334907-l4jjb93l	243	46	deleterious	deleterious	JJ
cord-334907-l4jjb93l	243	47	effect	effect	NN
cord-334907-l4jjb93l	243	48	to	to	IN
cord-334907-l4jjb93l	243	49	the	the	DT
cord-334907-l4jjb93l	243	50	host	host	NN
cord-334907-l4jjb93l	243	51	.	.	.
cord-334907-l4jjb93l	244	1	Further	further	JJ
cord-334907-l4jjb93l	244	2	studies	study	NNS
cord-334907-l4jjb93l	244	3	should	should	MD
cord-334907-l4jjb93l	244	4	focus	focus	VB
cord-334907-l4jjb93l	244	5	on	on	IN
cord-334907-l4jjb93l	244	6	resolving	resolve	VBG
cord-334907-l4jjb93l	244	7	the	the	DT
cord-334907-l4jjb93l	244	8	specific	specific	JJ
cord-334907-l4jjb93l	244	9	identity	identity	NN
cord-334907-l4jjb93l	244	10	of	of	IN
cord-334907-l4jjb93l	244	11	this	this	DT
cord-334907-l4jjb93l	244	12	sialic	sialic	JJ
cord-334907-l4jjb93l	244	13	acid	acid	NN
cord-334907-l4jjb93l	244	14	and	and	CC
cord-334907-l4jjb93l	244	15	its	-PRON-	PRP$
cord-334907-l4jjb93l	244	16	presence	presence	NN
cord-334907-l4jjb93l	244	17	in	in	IN
cord-334907-l4jjb93l	244	18	particular	particular	JJ
cord-334907-l4jjb93l	244	19	tissues	tissue	NNS
cord-334907-l4jjb93l	244	20	/	/	SYM
cord-334907-l4jjb93l	244	21	cells	cell	NNS
cord-334907-l4jjb93l	244	22	of	of	IN
cord-334907-l4jjb93l	244	23	the	the	DT
cord-334907-l4jjb93l	244	24	fish	fish	NN
cord-334907-l4jjb93l	244	25	.	.	.
cord-334907-l4jjb93l	245	1	In	in	IN
cord-334907-l4jjb93l	245	2	conclusion	conclusion	NN
cord-334907-l4jjb93l	245	3	,	,	,
cord-334907-l4jjb93l	245	4	we	-PRON-	PRP
cord-334907-l4jjb93l	245	5	have	have	VBP
cord-334907-l4jjb93l	245	6	demonstrated	demonstrate	VBN
cord-334907-l4jjb93l	245	7	a	a	DT
cord-334907-l4jjb93l	245	8	novel	novel	JJ
cord-334907-l4jjb93l	245	9	role	role	NN
cord-334907-l4jjb93l	245	10	for	for	IN
cord-334907-l4jjb93l	245	11	the	the	DT
cord-334907-l4jjb93l	245	12	F	F	NNP
cord-334907-l4jjb93l	245	13	protein	protein	NN
cord-334907-l4jjb93l	245	14	in	in	IN
cord-334907-l4jjb93l	245	15	ISAV	ISAV	NNP
cord-334907-l4jjb93l	245	16	,	,	,
cord-334907-l4jjb93l	245	17	where	where	WRB
cord-334907-l4jjb93l	245	18	interaction	interaction	NN
cord-334907-l4jjb93l	245	19	of	of	IN
cord-334907-l4jjb93l	245	20	the	the	DT
cord-334907-l4jjb93l	245	21	protein	protein	NN
cord-334907-l4jjb93l	245	22	with	with	IN
cord-334907-l4jjb93l	245	23	a	a	DT
cord-334907-l4jjb93l	245	24	sialic	sialic	JJ
cord-334907-l4jjb93l	245	25	acid	acid	NN
cord-334907-l4jjb93l	245	26	on	on	IN
cord-334907-l4jjb93l	245	27	the	the	DT
cord-334907-l4jjb93l	245	28	cell	cell	NN
cord-334907-l4jjb93l	245	29	surface	surface	NN
cord-334907-l4jjb93l	245	30	,	,	,
cord-334907-l4jjb93l	245	31	prior	prior	RB
cord-334907-l4jjb93l	245	32	to	to	IN
cord-334907-l4jjb93l	245	33	activation	activation	NN
cord-334907-l4jjb93l	245	34	,	,	,
cord-334907-l4jjb93l	245	35	can	can	MD
cord-334907-l4jjb93l	245	36	be	be	VB
cord-334907-l4jjb93l	245	37	a	a	DT
cord-334907-l4jjb93l	245	38	key	key	JJ
cord-334907-l4jjb93l	245	39	step	step	NN
cord-334907-l4jjb93l	245	40	for	for	IN
cord-334907-l4jjb93l	245	41	the	the	DT
cord-334907-l4jjb93l	245	42	membrane	membrane	NN
cord-334907-l4jjb93l	245	43	fusion	fusion	NN
cord-334907-l4jjb93l	245	44	process	process	NN
cord-334907-l4jjb93l	245	45	.	.	.
cord-334907-l4jjb93l	246	1	Highly	highly	RB
cord-334907-l4jjb93l	246	2	conserved	conserve	VBN
cord-334907-l4jjb93l	246	3	amino	amino	NN
cord-334907-l4jjb93l	246	4	acids	acid	NNS
cord-334907-l4jjb93l	246	5	on	on	IN
cord-334907-l4jjb93l	246	6	the	the	DT
cord-334907-l4jjb93l	246	7	F	F	NNP
cord-334907-l4jjb93l	246	8	1	1	CD
cord-334907-l4jjb93l	246	9	subdomain	subdomain	NN
cord-334907-l4jjb93l	246	10	are	be	VBP
cord-334907-l4jjb93l	246	11	crucial	crucial	JJ
cord-334907-l4jjb93l	246	12	for	for	IN
cord-334907-l4jjb93l	246	13	the	the	DT
cord-334907-l4jjb93l	246	14	protein	protein	NN
cord-334907-l4jjb93l	246	15	function	function	NN
cord-334907-l4jjb93l	246	16	and	and	CC
cord-334907-l4jjb93l	246	17	possibly	possibly	RB
cord-334907-l4jjb93l	246	18	related	related	JJ
cord-334907-l4jjb93l	246	19	to	to	IN
cord-334907-l4jjb93l	246	20	ligand	ligand	NN
cord-334907-l4jjb93l	246	21	binding	binding	NN
cord-334907-l4jjb93l	246	22	.	.	.
cord-334907-l4jjb93l	247	1	Moreover	moreover	RB
cord-334907-l4jjb93l	247	2	,	,	,
cord-334907-l4jjb93l	247	3	esterase	esterase	NN
cord-334907-l4jjb93l	247	4	activity	activity	NN
cord-334907-l4jjb93l	247	5	in	in	IN
cord-334907-l4jjb93l	247	6	HE	he	PRP
cord-334907-l4jjb93l	247	7	hydrolyses	hydrolyse	VBZ
cord-334907-l4jjb93l	247	8	the	the	DT
cord-334907-l4jjb93l	247	9	ligand	ligand	NN
cord-334907-l4jjb93l	247	10	for	for	IN
cord-334907-l4jjb93l	247	11	F	F	NNP
cord-334907-l4jjb93l	247	12	,	,	,
cord-334907-l4jjb93l	247	13	with	with	IN
cord-334907-l4jjb93l	247	14	the	the	DT
cord-334907-l4jjb93l	247	15	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	247	16	activity	activity	NN
cord-334907-l4jjb93l	247	17	being	be	VBG
cord-334907-l4jjb93l	247	18	regulated	regulate	VBN
cord-334907-l4jjb93l	247	19	by	by	IN
cord-334907-l4jjb93l	247	20	the	the	DT
cord-334907-l4jjb93l	247	21	length	length	NN
cord-334907-l4jjb93l	247	22	of	of	IN
cord-334907-l4jjb93l	247	23	the	the	DT
cord-334907-l4jjb93l	247	24	HPR	HPR	NNP
cord-334907-l4jjb93l	247	25	.	.	.
cord-334907-l4jjb93l	248	1	Figure	figure	NN
cord-334907-l4jjb93l	248	2	6	6	CD
cord-334907-l4jjb93l	248	3	depicts	depict	VBZ
cord-334907-l4jjb93l	248	4	the	the	DT
cord-334907-l4jjb93l	248	5	hypothetical	hypothetical	JJ
cord-334907-l4jjb93l	248	6	model	model	NN
cord-334907-l4jjb93l	248	7	we	-PRON-	PRP
cord-334907-l4jjb93l	248	8	propose	propose	VBP
cord-334907-l4jjb93l	248	9	for	for	IN
cord-334907-l4jjb93l	248	10	initial	initial	JJ
cord-334907-l4jjb93l	248	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	248	12	interaction	interaction	NN
cord-334907-l4jjb93l	248	13	with	with	IN
cord-334907-l4jjb93l	248	14	the	the	DT
cord-334907-l4jjb93l	248	15	cell	cell	NN
cord-334907-l4jjb93l	248	16	surface	surface	NN
cord-334907-l4jjb93l	248	17	,	,	,
cord-334907-l4jjb93l	248	18	derived	derive	VBN
cord-334907-l4jjb93l	248	19	from	from	IN
cord-334907-l4jjb93l	248	20	our	-PRON-	PRP$
cord-334907-l4jjb93l	248	21	results	result	NNS
cord-334907-l4jjb93l	248	22	and	and	CC
cord-334907-l4jjb93l	248	23	their	-PRON-	PRP$
cord-334907-l4jjb93l	248	24	interpretation	interpretation	NN
cord-334907-l4jjb93l	248	25	.	.	.
cord-334907-l4jjb93l	249	1	Pathogens	pathogen	NNS
cord-334907-l4jjb93l	249	2	2020	2020	CD
cord-334907-l4jjb93l	249	3	,	,	,
cord-334907-l4jjb93l	249	4	9	9	CD
cord-334907-l4jjb93l	249	5	,	,	,
cord-334907-l4jjb93l	249	6	x	x	NN
cord-334907-l4jjb93l	249	7	FOR	for	IN
cord-334907-l4jjb93l	249	8	PEER	PEER	NNP
cord-334907-l4jjb93l	249	9	REVIEW	REVIEW	NNP
cord-334907-l4jjb93l	249	10	10	10	CD
cord-334907-l4jjb93l	249	11	of	of	IN
cord-334907-l4jjb93l	249	12	18	18	CD
cord-334907-l4jjb93l	249	13	the	the	DT
cord-334907-l4jjb93l	249	14	ligand	ligand	NN
cord-334907-l4jjb93l	249	15	for	for	IN
cord-334907-l4jjb93l	249	16	F	F	NNP
cord-334907-l4jjb93l	249	17	,	,	,
cord-334907-l4jjb93l	249	18	with	with	IN
cord-334907-l4jjb93l	249	19	the	the	DT
cord-334907-l4jjb93l	249	20	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	249	21	activity	activity	NN
cord-334907-l4jjb93l	249	22	being	be	VBG
cord-334907-l4jjb93l	249	23	regulated	regulate	VBN
cord-334907-l4jjb93l	249	24	by	by	IN
cord-334907-l4jjb93l	249	25	the	the	DT
cord-334907-l4jjb93l	249	26	length	length	NN
cord-334907-l4jjb93l	249	27	of	of	IN
cord-334907-l4jjb93l	249	28	the	the	DT
cord-334907-l4jjb93l	249	29	HPR	HPR	NNP
cord-334907-l4jjb93l	249	30	.	.	.
cord-334907-l4jjb93l	250	1	Figure	figure	NN
cord-334907-l4jjb93l	250	2	6	6	CD
cord-334907-l4jjb93l	250	3	depicts	depict	VBZ
cord-334907-l4jjb93l	250	4	the	the	DT
cord-334907-l4jjb93l	250	5	hypothetical	hypothetical	JJ
cord-334907-l4jjb93l	250	6	model	model	NN
cord-334907-l4jjb93l	250	7	we	-PRON-	PRP
cord-334907-l4jjb93l	250	8	propose	propose	VBP
cord-334907-l4jjb93l	250	9	for	for	IN
cord-334907-l4jjb93l	250	10	initial	initial	JJ
cord-334907-l4jjb93l	250	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	250	12	interaction	interaction	NN
cord-334907-l4jjb93l	250	13	with	with	IN
cord-334907-l4jjb93l	250	14	the	the	DT
cord-334907-l4jjb93l	250	15	cell	cell	NN
cord-334907-l4jjb93l	250	16	surface	surface	NN
cord-334907-l4jjb93l	250	17	,	,	,
cord-334907-l4jjb93l	250	18	derived	derive	VBN
cord-334907-l4jjb93l	250	19	from	from	IN
cord-334907-l4jjb93l	250	20	our	-PRON-	PRP$
cord-334907-l4jjb93l	250	21	results	result	NNS
cord-334907-l4jjb93l	250	22	and	and	CC
cord-334907-l4jjb93l	250	23	their	-PRON-	PRP$
cord-334907-l4jjb93l	250	24	interpretation	interpretation	NN
cord-334907-l4jjb93l	250	25	.	.	.
cord-334907-l4jjb93l	251	1	The	the	DT
cord-334907-l4jjb93l	251	2	full	full	JJ
cord-334907-l4jjb93l	251	3	-	-	HYPH
cord-334907-l4jjb93l	251	4	length	length	NN
cord-334907-l4jjb93l	251	5	stalk	stalk	NN
cord-334907-l4jjb93l	251	6	on	on	IN
cord-334907-l4jjb93l	251	7	the	the	DT
cord-334907-l4jjb93l	251	8	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	251	9	augments	augment	VBZ
cord-334907-l4jjb93l	251	10	the	the	DT
cord-334907-l4jjb93l	251	11	activity	activity	NN
cord-334907-l4jjb93l	251	12	/	/	SYM
cord-334907-l4jjb93l	251	13	accessibility	accessibility	NN
cord-334907-l4jjb93l	251	14	of	of	IN
cord-334907-l4jjb93l	251	15	the	the	DT
cord-334907-l4jjb93l	251	16	esterase	esterase	NN
cord-334907-l4jjb93l	251	17	over	over	IN
cord-334907-l4jjb93l	251	18	a	a	DT
cord-334907-l4jjb93l	251	19	sialic	sialic	JJ
cord-334907-l4jjb93l	251	20	acid	acid	NN
cord-334907-l4jjb93l	251	21	,	,	,
cord-334907-l4jjb93l	251	22	which	which	WDT
cord-334907-l4jjb93l	251	23	acts	act	VBZ
cord-334907-l4jjb93l	251	24	as	as	IN
cord-334907-l4jjb93l	251	25	a	a	DT
cord-334907-l4jjb93l	251	26	receptor	receptor	NN
cord-334907-l4jjb93l	251	27	for	for	IN
cord-334907-l4jjb93l	251	28	F.	F.	NNP
cord-334907-l4jjb93l	251	29	Lack	Lack	NNP
cord-334907-l4jjb93l	251	30	of	of	IN
cord-334907-l4jjb93l	251	31	interaction	interaction	NN
cord-334907-l4jjb93l	251	32	of	of	IN
cord-334907-l4jjb93l	251	33	F1	F1	NNP
cord-334907-l4jjb93l	251	34	(	(	-LRB-
cord-334907-l4jjb93l	251	35	in	in	IN
cord-334907-l4jjb93l	251	36	purple	purple	NN
cord-334907-l4jjb93l	251	37	)	)	-RRB-
cord-334907-l4jjb93l	251	38	with	with	IN
cord-334907-l4jjb93l	251	39	the	the	DT
cord-334907-l4jjb93l	251	40	cell	cell	NN
cord-334907-l4jjb93l	251	41	surface	surface	NN
cord-334907-l4jjb93l	251	42	impairs	impair	VBZ
cord-334907-l4jjb93l	251	43	the	the	DT
cord-334907-l4jjb93l	251	44	activation	activation	NN
cord-334907-l4jjb93l	251	45	of	of	IN
cord-334907-l4jjb93l	251	46	the	the	DT
cord-334907-l4jjb93l	251	47	fusion	fusion	NN
cord-334907-l4jjb93l	251	48	mechanism	mechanism	NN
cord-334907-l4jjb93l	251	49	and	and	CC
cord-334907-l4jjb93l	251	50	ultimately	ultimately	RB
cord-334907-l4jjb93l	251	51	diminishes	diminish	VBZ
cord-334907-l4jjb93l	251	52	the	the	DT
cord-334907-l4jjb93l	251	53	infective	infective	JJ
cord-334907-l4jjb93l	251	54	capacity	capacity	NN
cord-334907-l4jjb93l	251	55	of	of	IN
cord-334907-l4jjb93l	251	56	these	these	DT
cord-334907-l4jjb93l	251	57	strains	strain	NNS
cord-334907-l4jjb93l	251	58	.	.	.
cord-334907-l4jjb93l	252	1	On	on	IN
cord-334907-l4jjb93l	252	2	the	the	DT
cord-334907-l4jjb93l	252	3	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	252	4	types	type	NNS
cord-334907-l4jjb93l	252	5	,	,	,
cord-334907-l4jjb93l	252	6	the	the	DT
cord-334907-l4jjb93l	252	7	shortened	shorten	VBN
cord-334907-l4jjb93l	252	8	stalk	stalk	NN
cord-334907-l4jjb93l	252	9	negatively	negatively	RB
cord-334907-l4jjb93l	252	10	regulates	regulate	VBZ
cord-334907-l4jjb93l	252	11	the	the	DT
cord-334907-l4jjb93l	252	12	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	252	13	activity	activity	NN
cord-334907-l4jjb93l	252	14	over	over	IN
cord-334907-l4jjb93l	252	15	the	the	DT
cord-334907-l4jjb93l	252	16	F	F	NNP
cord-334907-l4jjb93l	252	17	receptor	receptor	NN
cord-334907-l4jjb93l	252	18	,	,	,
cord-334907-l4jjb93l	252	19	allowing	allow	VBG
cord-334907-l4jjb93l	252	20	the	the	DT
cord-334907-l4jjb93l	252	21	interaction	interaction	NN
cord-334907-l4jjb93l	252	22	of	of	IN
cord-334907-l4jjb93l	252	23	F1	F1	NNP
cord-334907-l4jjb93l	252	24	with	with	IN
cord-334907-l4jjb93l	252	25	this	this	DT
cord-334907-l4jjb93l	252	26	sialic	sialic	JJ
cord-334907-l4jjb93l	252	27	acid	acid	NN
cord-334907-l4jjb93l	252	28	and	and	CC
cord-334907-l4jjb93l	252	29	,	,	,
cord-334907-l4jjb93l	252	30	finally	finally	RB
cord-334907-l4jjb93l	252	31	,	,	,
cord-334907-l4jjb93l	252	32	the	the	DT
cord-334907-l4jjb93l	252	33	successful	successful	JJ
cord-334907-l4jjb93l	252	34	activation	activation	NN
cord-334907-l4jjb93l	252	35	of	of	IN
cord-334907-l4jjb93l	252	36	the	the	DT
cord-334907-l4jjb93l	252	37	fusion	fusion	NN
cord-334907-l4jjb93l	252	38	mechanism	mechanism	NN
cord-334907-l4jjb93l	252	39	.	.	.
cord-334907-l4jjb93l	253	1	Atlantic	atlantic	JJ
cord-334907-l4jjb93l	253	2	salmon	salmon	NN
cord-334907-l4jjb93l	253	3	kidney	kidney	NN
cord-334907-l4jjb93l	253	4	(	(	-LRB-
cord-334907-l4jjb93l	253	5	ASK	ask	VB
cord-334907-l4jjb93l	253	6	)	)	-RRB-
cord-334907-l4jjb93l	253	7	cells	cell	NNS
cord-334907-l4jjb93l	253	8	(	(	-LRB-
cord-334907-l4jjb93l	253	9	ATCC	ATCC	NNP
cord-334907-l4jjb93l	253	10	CRL2747	CRL2747	NNP
cord-334907-l4jjb93l	253	11	)	)	-RRB-
cord-334907-l4jjb93l	253	12	[	[	-LRB-
cord-334907-l4jjb93l	253	13	50	50	CD
cord-334907-l4jjb93l	253	14	]	]	-RRB-
cord-334907-l4jjb93l	253	15	and	and	CC
cord-334907-l4jjb93l	253	16	common	common	JJ
cord-334907-l4jjb93l	253	17	bluegill	bluegill	NN
cord-334907-l4jjb93l	253	18	embryo	embryo	NN
cord-334907-l4jjb93l	253	19	(	(	-LRB-
cord-334907-l4jjb93l	253	20	CHSE	CHSE	NNP
cord-334907-l4jjb93l	253	21	/	/	SYM
cord-334907-l4jjb93l	253	22	F	F	NNP
cord-334907-l4jjb93l	253	23	)	)	-RRB-
cord-334907-l4jjb93l	253	24	cells	cell	NNS
cord-334907-l4jjb93l	253	25	(	(	-LRB-
cord-334907-l4jjb93l	253	26	formerly	formerly	RB
cord-334907-l4jjb93l	253	27	known	know	VBN
cord-334907-l4jjb93l	253	28	as	as	IN
cord-334907-l4jjb93l	253	29	CHSE-214	CHSE-214	NNP
cord-334907-l4jjb93l	253	30	,	,	,
cord-334907-l4jjb93l	253	31	ATCC	ATCC	NNP
cord-334907-l4jjb93l	253	32	1681	1681	CD
cord-334907-l4jjb93l	253	33	)	)	-RRB-
cord-334907-l4jjb93l	254	1	[	[	-LRB-
cord-334907-l4jjb93l	254	2	51	51	CD
cord-334907-l4jjb93l	254	3	]	]	-RRB-
cord-334907-l4jjb93l	254	4	were	be	VBD
cord-334907-l4jjb93l	254	5	cultured	culture	VBN
cord-334907-l4jjb93l	254	6	in	in	IN
cord-334907-l4jjb93l	254	7	Leibovitz	Leibovitz	NNP
cord-334907-l4jjb93l	254	8	's	's	POS
cord-334907-l4jjb93l	254	9	L-15	L-15	NNP
cord-334907-l4jjb93l	254	10	medium	medium	NN
cord-334907-l4jjb93l	254	11	with	with	IN
cord-334907-l4jjb93l	254	12	4	4	CD
cord-334907-l4jjb93l	254	13	mM	mm	CD
cord-334907-l4jjb93l	254	14	glutamine	glutamine	NN
cord-334907-l4jjb93l	254	15	(	(	-LRB-
cord-334907-l4jjb93l	254	16	Gibco	Gibco	NNP
cord-334907-l4jjb93l	254	17	)	)	-RRB-
cord-334907-l4jjb93l	254	18	and	and	CC
cord-334907-l4jjb93l	254	19	supplemented	supplement	VBN
cord-334907-l4jjb93l	254	20	with	with	IN
cord-334907-l4jjb93l	254	21	200	200	CD
cord-334907-l4jjb93l	254	22	U	u	NN
cord-334907-l4jjb93l	254	23	/	/	SYM
cord-334907-l4jjb93l	254	24	mL	ml	NN
cord-334907-l4jjb93l	254	25	penicillin	penicillin	NN
cord-334907-l4jjb93l	254	26	,	,	,
cord-334907-l4jjb93l	254	27	200	200	CD
cord-334907-l4jjb93l	254	28	µ	µ	NN
cord-334907-l4jjb93l	254	29	g	g	NN
cord-334907-l4jjb93l	254	30	/	/	SYM
cord-334907-l4jjb93l	254	31	mL	ml	NN
cord-334907-l4jjb93l	254	32	streptomycin	streptomycin	NNS
cord-334907-l4jjb93l	254	33	,	,	,
cord-334907-l4jjb93l	254	34	0.5	0.5	CD
cord-334907-l4jjb93l	254	35	µ	µ	NN
cord-334907-l4jjb93l	254	36	g	g	NN
cord-334907-l4jjb93l	254	37	/	/	SYM
cord-334907-l4jjb93l	254	38	mL	ml	NN
cord-334907-l4jjb93l	254	39	amphotericin	amphotericin	NNS
cord-334907-l4jjb93l	254	40	,	,	,
cord-334907-l4jjb93l	254	41	and	and	CC
cord-334907-l4jjb93l	254	42	10	10	CD
cord-334907-l4jjb93l	254	43	%	%	NN
cord-334907-l4jjb93l	254	44	fetal	fetal	JJ
cord-334907-l4jjb93l	254	45	bovine	bovine	JJ
cord-334907-l4jjb93l	254	46	serum	serum	NN
cord-334907-l4jjb93l	254	47	(	(	-LRB-
cord-334907-l4jjb93l	254	48	Gibco	Gibco	NNP
cord-334907-l4jjb93l	254	49	)	)	-RRB-
cord-334907-l4jjb93l	254	50	,	,	,
cord-334907-l4jjb93l	254	51	at	at	IN
cord-334907-l4jjb93l	254	52	20	20	CD
cord-334907-l4jjb93l	254	53	°	°	NN
cord-334907-l4jjb93l	254	54	C	c	NN
cord-334907-l4jjb93l	254	55	.	.	.
cord-334907-l4jjb93l	255	1	Cells	cell	NNS
cord-334907-l4jjb93l	255	2	were	be	VBD
cord-334907-l4jjb93l	255	3	grown	grow	VBN
cord-334907-l4jjb93l	255	4	to	to	IN
cord-334907-l4jjb93l	255	5	80	80	CD
cord-334907-l4jjb93l	255	6	%	%	NN
cord-334907-l4jjb93l	255	7	confluence	confluence	NN
cord-334907-l4jjb93l	255	8	and	and	CC
cord-334907-l4jjb93l	255	9	accordingly	accordingly	RB
cord-334907-l4jjb93l	255	10	subcultured	subculture	VBN
cord-334907-l4jjb93l	255	11	.	.	.
cord-334907-l4jjb93l	256	1	Field	field	NN
cord-334907-l4jjb93l	256	2	isolates	isolate	NNS
cord-334907-l4jjb93l	256	3	of	of	IN
cord-334907-l4jjb93l	256	4	ISAV	ISAV	NNP
cord-334907-l4jjb93l	256	5	corresponding	correspond	VBG
cord-334907-l4jjb93l	256	6	to	to	IN
cord-334907-l4jjb93l	256	7	the	the	DT
cord-334907-l4jjb93l	256	8	HPR3	HPR3	NNP
cord-334907-l4jjb93l	256	9	and	and	CC
cord-334907-l4jjb93l	256	10	HPR7b	HPR7b	NNP
cord-334907-l4jjb93l	256	11	types	type	NNS
cord-334907-l4jjb93l	256	12	were	be	VBD
cord-334907-l4jjb93l	256	13	obtained	obtain	VBN
cord-334907-l4jjb93l	256	14	from	from	IN
cord-334907-l4jjb93l	256	15	the	the	DT
cord-334907-l4jjb93l	256	16	Laboratorio	Laboratorio	NNP
cord-334907-l4jjb93l	256	17	de	de	NNP
cord-334907-l4jjb93l	256	18	Genética	Genética	NNP
cord-334907-l4jjb93l	256	19	e	e	NNP
cord-334907-l4jjb93l	256	20	Inmunología	Inmunología	NNP
cord-334907-l4jjb93l	256	21	molecular	molecular	JJ
cord-334907-l4jjb93l	256	22	strain	strain	NN
cord-334907-l4jjb93l	256	23	collection	collection	NN
cord-334907-l4jjb93l	256	24	.	.	.
cord-334907-l4jjb93l	257	1	Viral	viral	JJ
cord-334907-l4jjb93l	257	2	infection	infection	NN
cord-334907-l4jjb93l	257	3	and	and	CC
cord-334907-l4jjb93l	257	4	propagation	propagation	NN
cord-334907-l4jjb93l	257	5	were	be	VBD
cord-334907-l4jjb93l	257	6	performed	perform	VBN
cord-334907-l4jjb93l	257	7	using	use	VBG
cord-334907-l4jjb93l	257	8	ASK	ask	NN
cord-334907-l4jjb93l	257	9	cells	cell	NNS
cord-334907-l4jjb93l	257	10	,	,	,
cord-334907-l4jjb93l	257	11	where	where	WRB
cord-334907-l4jjb93l	257	12	an	an	DT
cord-334907-l4jjb93l	257	13	80	80	CD
cord-334907-l4jjb93l	257	14	%	%	NN
cord-334907-l4jjb93l	257	15	confluent	confluent	JJ
cord-334907-l4jjb93l	257	16	cell	cell	NN
cord-334907-l4jjb93l	257	17	monolayer	monolayer	NN
cord-334907-l4jjb93l	257	18	was	be	VBD
cord-334907-l4jjb93l	257	19	washed	wash	VBN
cord-334907-l4jjb93l	257	20	twice	twice	RB
cord-334907-l4jjb93l	257	21	with	with	IN
cord-334907-l4jjb93l	257	22	L-15	L-15	NNP
cord-334907-l4jjb93l	257	23	medium	medium	NN
cord-334907-l4jjb93l	257	24	and	and	CC
cord-334907-l4jjb93l	257	25	further	further	RB
cord-334907-l4jjb93l	257	26	covered	cover	VBN
cord-334907-l4jjb93l	257	27	with	with	IN
cord-334907-l4jjb93l	257	28	a	a	DT
cord-334907-l4jjb93l	257	29	viral	viral	JJ
cord-334907-l4jjb93l	257	30	dilution	dilution	NN
cord-334907-l4jjb93l	257	31	prepared	prepare	VBN
cord-334907-l4jjb93l	257	32	in	in	IN
cord-334907-l4jjb93l	257	33	L-15	L-15	NNP
cord-334907-l4jjb93l	257	34	medium	medium	NN
cord-334907-l4jjb93l	257	35	.	.	.
cord-334907-l4jjb93l	258	1	After	after	IN
cord-334907-l4jjb93l	258	2	4	4	CD
cord-334907-l4jjb93l	258	3	h	h	NN
cord-334907-l4jjb93l	258	4	of	of	IN
cord-334907-l4jjb93l	258	5	incubation	incubation	NN
cord-334907-l4jjb93l	258	6	,	,	,
cord-334907-l4jjb93l	258	7	the	the	DT
cord-334907-l4jjb93l	258	8	viral	viral	JJ
cord-334907-l4jjb93l	258	9	inoculum	inoculum	NN
cord-334907-l4jjb93l	258	10	was	be	VBD
cord-334907-l4jjb93l	258	11	removed	remove	VBN
cord-334907-l4jjb93l	258	12	,	,	,
cord-334907-l4jjb93l	258	13	and	and	CC
cord-334907-l4jjb93l	258	14	the	the	DT
cord-334907-l4jjb93l	258	15	cells	cell	NNS
cord-334907-l4jjb93l	258	16	were	be	VBD
cord-334907-l4jjb93l	258	17	washed	wash	VBN
cord-334907-l4jjb93l	258	18	twice	twice	RB
cord-334907-l4jjb93l	258	19	with	with	IN
cord-334907-l4jjb93l	258	20	L-15	L-15	NNP
cord-334907-l4jjb93l	258	21	medium	medium	NN
cord-334907-l4jjb93l	258	22	and	and	CC
cord-334907-l4jjb93l	258	23	further	further	RB
cord-334907-l4jjb93l	258	24	cultured	cultured	JJ
cord-334907-l4jjb93l	258	25	in	in	IN
cord-334907-l4jjb93l	258	26	L-15	L-15	NNP
cord-334907-l4jjb93l	258	27	medium	medium	NN
cord-334907-l4jjb93l	258	28	supplemented	supplement	VBN
cord-334907-l4jjb93l	258	29	with	with	IN
cord-334907-l4jjb93l	258	30	2	2	CD
cord-334907-l4jjb93l	258	31	%	%	NN
cord-334907-l4jjb93l	258	32	fetal	fetal	JJ
cord-334907-l4jjb93l	258	33	bovine	bovine	JJ
cord-334907-l4jjb93l	258	34	serum	serum	NN
cord-334907-l4jjb93l	258	35	and	and	CC
cord-334907-l4jjb93l	258	36	antibiotics	antibiotic	NNS
cord-334907-l4jjb93l	258	37	,	,	,
cord-334907-l4jjb93l	258	38	at	at	IN
cord-334907-l4jjb93l	258	39	17	17	CD
cord-334907-l4jjb93l	258	40	°	°	NN
cord-334907-l4jjb93l	258	41	C	c	NN
cord-334907-l4jjb93l	258	42	.	.	.
cord-334907-l4jjb93l	259	1	After	after	IN
cord-334907-l4jjb93l	259	2	7	7	CD
cord-334907-l4jjb93l	259	3	days	day	NNS
cord-334907-l4jjb93l	259	4	,	,	,
cord-334907-l4jjb93l	259	5	the	the	DT
cord-334907-l4jjb93l	259	6	cell	cell	NN
cord-334907-l4jjb93l	259	7	supernatant	supernatant	NN
cord-334907-l4jjb93l	259	8	was	be	VBD
cord-334907-l4jjb93l	259	9	recovered	recover	VBN
cord-334907-l4jjb93l	259	10	and	and	CC
cord-334907-l4jjb93l	259	11	filtered	filter	VBN
cord-334907-l4jjb93l	259	12	(	(	-LRB-
cord-334907-l4jjb93l	259	13	0.45	0.45	CD
cord-334907-l4jjb93l	259	14	μm	μm	NNP
cord-334907-l4jjb93l	259	15	)	)	-RRB-
cord-334907-l4jjb93l	259	16	,	,	,
cord-334907-l4jjb93l	259	17	and	and	CC
cord-334907-l4jjb93l	259	18	viral	viral	JJ
cord-334907-l4jjb93l	259	19	aliquots	aliquot	NNS
cord-334907-l4jjb93l	259	20	were	be	VBD
cord-334907-l4jjb93l	259	21	collected	collect	VBN
cord-334907-l4jjb93l	259	22	and	and	CC
cord-334907-l4jjb93l	259	23	stored	store	VBN
cord-334907-l4jjb93l	259	24	at	at	IN
cord-334907-l4jjb93l	259	25	−80	−80	NNP
cord-334907-l4jjb93l	259	26	°	°	NN
cord-334907-l4jjb93l	259	27	C	C	NNP
cord-334907-l4jjb93l	259	28	.	.	.
cord-334907-l4jjb93l	260	1	A	a	DT
cord-334907-l4jjb93l	260	2	plaque	plaque	NN
cord-334907-l4jjb93l	260	3	assay	assay	NN
cord-334907-l4jjb93l	260	4	was	be	VBD
cord-334907-l4jjb93l	260	5	used	use	VBN
cord-334907-l4jjb93l	260	6	for	for	IN
cord-334907-l4jjb93l	260	7	virus	virus	NN
cord-334907-l4jjb93l	260	8	tittering	titter	VBG
cord-334907-l4jjb93l	260	9	12	12	CD
cord-334907-l4jjb93l	260	10	days	day	NNS
cord-334907-l4jjb93l	260	11	post	post	NN
cord-334907-l4jjb93l	260	12	-	-	NN
cord-334907-l4jjb93l	260	13	infection	infection	JJ
cord-334907-l4jjb93l	260	14	(	(	-LRB-
cord-334907-l4jjb93l	260	15	d.p.i	d.p.i	NNP
cord-334907-l4jjb93l	260	16	.	.	.
cord-334907-l4jjb93l	260	17	)	)	-RRB-
cord-334907-l4jjb93l	260	18	,	,	,
cord-334907-l4jjb93l	260	19	as	as	IN
cord-334907-l4jjb93l	260	20	previously	previously	RB
cord-334907-l4jjb93l	260	21	described	describe	VBN
cord-334907-l4jjb93l	260	22	[	[	-LRB-
cord-334907-l4jjb93l	260	23	52	52	CD
cord-334907-l4jjb93l	260	24	]	]	-RRB-
cord-334907-l4jjb93l	260	25	.	.	.
cord-334907-l4jjb93l	261	1	Spodoptera	Spodoptera	NNP
cord-334907-l4jjb93l	261	2	frugiperda	frugiperda	NN
cord-334907-l4jjb93l	261	3	(	(	-LRB-
cord-334907-l4jjb93l	261	4	Sf21	sf21	NN
cord-334907-l4jjb93l	261	5	)	)	-RRB-
cord-334907-l4jjb93l	262	1	cells	cell	NNS
cord-334907-l4jjb93l	262	2	were	be	VBD
cord-334907-l4jjb93l	262	3	used	use	VBN
cord-334907-l4jjb93l	262	4	for	for	IN
cord-334907-l4jjb93l	262	5	recombinant	recombinant	JJ
cord-334907-l4jjb93l	262	6	baculovirus	baculovirus	NN
cord-334907-l4jjb93l	262	7	production	production	NN
cord-334907-l4jjb93l	262	8	and	and	CC
cord-334907-l4jjb93l	262	9	recombinant	recombinant	JJ
cord-334907-l4jjb93l	262	10	protein	protein	NN
cord-334907-l4jjb93l	262	11	expression	expression	NN
cord-334907-l4jjb93l	262	12	.	.	.
cord-334907-l4jjb93l	263	1	Cells	cell	NNS
cord-334907-l4jjb93l	263	2	were	be	VBD
cord-334907-l4jjb93l	263	3	grown	grow	VBN
cord-334907-l4jjb93l	263	4	in	in	IN
cord-334907-l4jjb93l	263	5	suspension	suspension	NN
cord-334907-l4jjb93l	263	6	culture	culture	NN
cord-334907-l4jjb93l	263	7	using	use	VBG
cord-334907-l4jjb93l	263	8	SF-900	SF-900	NNP
cord-334907-l4jjb93l	263	9	III	III	NNP
cord-334907-l4jjb93l	263	10	medium	medium	NN
cord-334907-l4jjb93l	264	1	The	the	DT
cord-334907-l4jjb93l	264	2	full	full	JJ
cord-334907-l4jjb93l	264	3	-	-	HYPH
cord-334907-l4jjb93l	264	4	length	length	NN
cord-334907-l4jjb93l	264	5	stalk	stalk	NN
cord-334907-l4jjb93l	264	6	on	on	IN
cord-334907-l4jjb93l	264	7	the	the	DT
cord-334907-l4jjb93l	264	8	HPR0-type	HPR0-type	NNP
cord-334907-l4jjb93l	264	9	augments	augment	VBZ
cord-334907-l4jjb93l	264	10	the	the	DT
cord-334907-l4jjb93l	264	11	activity	activity	NN
cord-334907-l4jjb93l	264	12	/	/	SYM
cord-334907-l4jjb93l	264	13	accessibility	accessibility	NN
cord-334907-l4jjb93l	264	14	of	of	IN
cord-334907-l4jjb93l	264	15	the	the	DT
cord-334907-l4jjb93l	264	16	esterase	esterase	NN
cord-334907-l4jjb93l	264	17	over	over	IN
cord-334907-l4jjb93l	264	18	a	a	DT
cord-334907-l4jjb93l	264	19	sialic	sialic	JJ
cord-334907-l4jjb93l	264	20	acid	acid	NN
cord-334907-l4jjb93l	264	21	,	,	,
cord-334907-l4jjb93l	264	22	which	which	WDT
cord-334907-l4jjb93l	264	23	acts	act	VBZ
cord-334907-l4jjb93l	264	24	as	as	IN
cord-334907-l4jjb93l	264	25	a	a	DT
cord-334907-l4jjb93l	264	26	receptor	receptor	NN
cord-334907-l4jjb93l	264	27	for	for	IN
cord-334907-l4jjb93l	264	28	F.	F.	NNP
cord-334907-l4jjb93l	264	29	Lack	Lack	NNP
cord-334907-l4jjb93l	264	30	of	of	IN
cord-334907-l4jjb93l	264	31	interaction	interaction	NN
cord-334907-l4jjb93l	264	32	of	of	IN
cord-334907-l4jjb93l	264	33	F	F	NNP
cord-334907-l4jjb93l	264	34	1	1	CD
cord-334907-l4jjb93l	264	35	(	(	-LRB-
cord-334907-l4jjb93l	264	36	in	in	IN
cord-334907-l4jjb93l	264	37	purple	purple	NN
cord-334907-l4jjb93l	264	38	)	)	-RRB-
cord-334907-l4jjb93l	264	39	with	with	IN
cord-334907-l4jjb93l	264	40	the	the	DT
cord-334907-l4jjb93l	264	41	cell	cell	NN
cord-334907-l4jjb93l	264	42	surface	surface	NN
cord-334907-l4jjb93l	264	43	impairs	impair	VBZ
cord-334907-l4jjb93l	264	44	the	the	DT
cord-334907-l4jjb93l	264	45	activation	activation	NN
cord-334907-l4jjb93l	264	46	of	of	IN
cord-334907-l4jjb93l	264	47	the	the	DT
cord-334907-l4jjb93l	264	48	fusion	fusion	NN
cord-334907-l4jjb93l	264	49	mechanism	mechanism	NN
cord-334907-l4jjb93l	264	50	and	and	CC
cord-334907-l4jjb93l	264	51	ultimately	ultimately	RB
cord-334907-l4jjb93l	264	52	diminishes	diminish	VBZ
cord-334907-l4jjb93l	264	53	the	the	DT
cord-334907-l4jjb93l	264	54	infective	infective	JJ
cord-334907-l4jjb93l	264	55	capacity	capacity	NN
cord-334907-l4jjb93l	264	56	of	of	IN
cord-334907-l4jjb93l	264	57	these	these	DT
cord-334907-l4jjb93l	264	58	strains	strain	NNS
cord-334907-l4jjb93l	264	59	.	.	.
cord-334907-l4jjb93l	265	1	On	on	IN
cord-334907-l4jjb93l	265	2	the	the	DT
cord-334907-l4jjb93l	265	3	HPR∆	HPR∆	NNP
cord-334907-l4jjb93l	265	4	types	type	NNS
cord-334907-l4jjb93l	265	5	,	,	,
cord-334907-l4jjb93l	265	6	the	the	DT
cord-334907-l4jjb93l	265	7	shortened	shorten	VBN
cord-334907-l4jjb93l	265	8	stalk	stalk	NN
cord-334907-l4jjb93l	265	9	negatively	negatively	RB
cord-334907-l4jjb93l	265	10	regulates	regulate	VBZ
cord-334907-l4jjb93l	265	11	the	the	DT
cord-334907-l4jjb93l	265	12	enzymatic	enzymatic	JJ
cord-334907-l4jjb93l	265	13	activity	activity	NN
cord-334907-l4jjb93l	265	14	over	over	IN
cord-334907-l4jjb93l	265	15	the	the	DT
cord-334907-l4jjb93l	265	16	F	F	NNP
cord-334907-l4jjb93l	265	17	receptor	receptor	NN
cord-334907-l4jjb93l	265	18	,	,	,
cord-334907-l4jjb93l	265	19	allowing	allow	VBG
cord-334907-l4jjb93l	265	20	the	the	DT
cord-334907-l4jjb93l	265	21	interaction	interaction	NN
cord-334907-l4jjb93l	265	22	of	of	IN
cord-334907-l4jjb93l	265	23	F	F	NNP
cord-334907-l4jjb93l	265	24	1	1	CD
cord-334907-l4jjb93l	265	25	with	with	IN
cord-334907-l4jjb93l	265	26	this	this	DT
cord-334907-l4jjb93l	265	27	sialic	sialic	JJ
cord-334907-l4jjb93l	265	28	acid	acid	NN
cord-334907-l4jjb93l	265	29	and	and	CC
cord-334907-l4jjb93l	265	30	,	,	,
cord-334907-l4jjb93l	265	31	finally	finally	RB
cord-334907-l4jjb93l	265	32	,	,	,
cord-334907-l4jjb93l	265	33	the	the	DT
cord-334907-l4jjb93l	265	34	successful	successful	JJ
cord-334907-l4jjb93l	265	35	activation	activation	NN
cord-334907-l4jjb93l	265	36	of	of	IN
cord-334907-l4jjb93l	265	37	the	the	DT
cord-334907-l4jjb93l	265	38	fusion	fusion	NN
cord-334907-l4jjb93l	265	39	mechanism	mechanism	NN
cord-334907-l4jjb93l	265	40	.	.	.
cord-334907-l4jjb93l	266	1	Atlantic	atlantic	JJ
cord-334907-l4jjb93l	266	2	salmon	salmon	NN
cord-334907-l4jjb93l	266	3	kidney	kidney	NN
cord-334907-l4jjb93l	266	4	(	(	-LRB-
cord-334907-l4jjb93l	266	5	ASK	ask	VB
cord-334907-l4jjb93l	266	6	)	)	-RRB-
cord-334907-l4jjb93l	266	7	cells	cell	NNS
cord-334907-l4jjb93l	266	8	(	(	-LRB-
cord-334907-l4jjb93l	266	9	ATCC	ATCC	NNP
cord-334907-l4jjb93l	266	10	CRL2747	CRL2747	NNP
cord-334907-l4jjb93l	266	11	)	)	-RRB-
cord-334907-l4jjb93l	266	12	[	[	-LRB-
cord-334907-l4jjb93l	266	13	50	50	CD
cord-334907-l4jjb93l	266	14	]	]	-RRB-
cord-334907-l4jjb93l	266	15	and	and	CC
cord-334907-l4jjb93l	266	16	common	common	JJ
cord-334907-l4jjb93l	266	17	bluegill	bluegill	NN
cord-334907-l4jjb93l	266	18	embryo	embryo	NN
cord-334907-l4jjb93l	266	19	(	(	-LRB-
cord-334907-l4jjb93l	266	20	CHSE	CHSE	NNP
cord-334907-l4jjb93l	266	21	/	/	SYM
cord-334907-l4jjb93l	266	22	F	F	NNP
cord-334907-l4jjb93l	266	23	)	)	-RRB-
cord-334907-l4jjb93l	266	24	cells	cell	NNS
cord-334907-l4jjb93l	266	25	(	(	-LRB-
cord-334907-l4jjb93l	266	26	formerly	formerly	RB
cord-334907-l4jjb93l	266	27	known	know	VBN
cord-334907-l4jjb93l	266	28	as	as	IN
cord-334907-l4jjb93l	266	29	CHSE-214	CHSE-214	NNP
cord-334907-l4jjb93l	266	30	,	,	,
cord-334907-l4jjb93l	266	31	ATCC	ATCC	NNP
cord-334907-l4jjb93l	266	32	1681	1681	CD
cord-334907-l4jjb93l	266	33	)	)	-RRB-
cord-334907-l4jjb93l	267	1	[	[	-LRB-
cord-334907-l4jjb93l	267	2	51	51	CD
cord-334907-l4jjb93l	267	3	]	]	-RRB-
cord-334907-l4jjb93l	267	4	were	be	VBD
cord-334907-l4jjb93l	267	5	cultured	culture	VBN
cord-334907-l4jjb93l	267	6	in	in	IN
cord-334907-l4jjb93l	267	7	Leibovitz	Leibovitz	NNP
cord-334907-l4jjb93l	267	8	's	's	POS
cord-334907-l4jjb93l	267	9	L-15	L-15	NNP
cord-334907-l4jjb93l	267	10	medium	medium	NN
cord-334907-l4jjb93l	267	11	with	with	IN
cord-334907-l4jjb93l	267	12	4	4	CD
cord-334907-l4jjb93l	267	13	mM	mm	CD
cord-334907-l4jjb93l	267	14	glutamine	glutamine	NN
cord-334907-l4jjb93l	267	15	(	(	-LRB-
cord-334907-l4jjb93l	267	16	Gibco	Gibco	NNP
cord-334907-l4jjb93l	267	17	)	)	-RRB-
cord-334907-l4jjb93l	267	18	and	and	CC
cord-334907-l4jjb93l	267	19	supplemented	supplement	VBN
cord-334907-l4jjb93l	267	20	with	with	IN
cord-334907-l4jjb93l	267	21	200	200	CD
cord-334907-l4jjb93l	267	22	U	u	NN
cord-334907-l4jjb93l	267	23	/	/	SYM
cord-334907-l4jjb93l	267	24	mL	ml	NN
cord-334907-l4jjb93l	267	25	penicillin	penicillin	NN
cord-334907-l4jjb93l	267	26	,	,	,
cord-334907-l4jjb93l	267	27	200	200	CD
cord-334907-l4jjb93l	267	28	µg	µg	NN
cord-334907-l4jjb93l	267	29	/	/	SYM
cord-334907-l4jjb93l	267	30	mL	ml	NN
cord-334907-l4jjb93l	267	31	streptomycin	streptomycin	NNS
cord-334907-l4jjb93l	267	32	,	,	,
cord-334907-l4jjb93l	267	33	0.5	0.5	CD
cord-334907-l4jjb93l	267	34	µg	µg	NN
cord-334907-l4jjb93l	267	35	/	/	SYM
cord-334907-l4jjb93l	267	36	mL	ml	NN
cord-334907-l4jjb93l	267	37	amphotericin	amphotericin	NNS
cord-334907-l4jjb93l	267	38	,	,	,
cord-334907-l4jjb93l	267	39	and	and	CC
cord-334907-l4jjb93l	267	40	10	10	CD
cord-334907-l4jjb93l	267	41	%	%	NN
cord-334907-l4jjb93l	267	42	fetal	fetal	JJ
cord-334907-l4jjb93l	267	43	bovine	bovine	JJ
cord-334907-l4jjb93l	267	44	serum	serum	NN
cord-334907-l4jjb93l	267	45	(	(	-LRB-
cord-334907-l4jjb93l	267	46	Gibco	Gibco	NNP
cord-334907-l4jjb93l	267	47	)	)	-RRB-
cord-334907-l4jjb93l	267	48	,	,	,
cord-334907-l4jjb93l	267	49	at	at	IN
cord-334907-l4jjb93l	267	50	20	20	CD
cord-334907-l4jjb93l	267	51	•	•	NNP
cord-334907-l4jjb93l	267	52	C.	C.	NNP
cord-334907-l4jjb93l	267	53	Cells	cell	NNS
cord-334907-l4jjb93l	267	54	were	be	VBD
cord-334907-l4jjb93l	267	55	grown	grow	VBN
cord-334907-l4jjb93l	267	56	to	to	IN
cord-334907-l4jjb93l	267	57	80	80	CD
cord-334907-l4jjb93l	267	58	%	%	NN
cord-334907-l4jjb93l	267	59	confluence	confluence	NN
cord-334907-l4jjb93l	267	60	and	and	CC
cord-334907-l4jjb93l	267	61	accordingly	accordingly	RB
cord-334907-l4jjb93l	267	62	subcultured	subculture	VBN
cord-334907-l4jjb93l	267	63	.	.	.
cord-334907-l4jjb93l	268	1	Field	field	NN
cord-334907-l4jjb93l	268	2	isolates	isolate	NNS
cord-334907-l4jjb93l	268	3	of	of	IN
cord-334907-l4jjb93l	268	4	ISAV	ISAV	NNP
cord-334907-l4jjb93l	268	5	corresponding	correspond	VBG
cord-334907-l4jjb93l	268	6	to	to	IN
cord-334907-l4jjb93l	268	7	the	the	DT
cord-334907-l4jjb93l	268	8	HPR3	HPR3	NNP
cord-334907-l4jjb93l	268	9	and	and	CC
cord-334907-l4jjb93l	268	10	HPR7b	HPR7b	NNP
cord-334907-l4jjb93l	268	11	types	type	NNS
cord-334907-l4jjb93l	268	12	were	be	VBD
cord-334907-l4jjb93l	268	13	obtained	obtain	VBN
cord-334907-l4jjb93l	268	14	from	from	IN
cord-334907-l4jjb93l	268	15	the	the	DT
cord-334907-l4jjb93l	268	16	Laboratorio	Laboratorio	NNP
cord-334907-l4jjb93l	268	17	de	de	NNP
cord-334907-l4jjb93l	268	18	Genética	Genética	NNP
cord-334907-l4jjb93l	268	19	e	e	NNP
cord-334907-l4jjb93l	268	20	Inmunología	Inmunología	NNP
cord-334907-l4jjb93l	268	21	molecular	molecular	JJ
cord-334907-l4jjb93l	268	22	strain	strain	NN
cord-334907-l4jjb93l	268	23	collection	collection	NN
cord-334907-l4jjb93l	268	24	.	.	.
cord-334907-l4jjb93l	269	1	Viral	viral	JJ
cord-334907-l4jjb93l	269	2	infection	infection	NN
cord-334907-l4jjb93l	269	3	and	and	CC
cord-334907-l4jjb93l	269	4	propagation	propagation	NN
cord-334907-l4jjb93l	269	5	were	be	VBD
cord-334907-l4jjb93l	269	6	performed	perform	VBN
cord-334907-l4jjb93l	269	7	using	use	VBG
cord-334907-l4jjb93l	269	8	ASK	ask	NN
cord-334907-l4jjb93l	269	9	cells	cell	NNS
cord-334907-l4jjb93l	269	10	,	,	,
cord-334907-l4jjb93l	269	11	where	where	WRB
cord-334907-l4jjb93l	269	12	an	an	DT
cord-334907-l4jjb93l	269	13	80	80	CD
cord-334907-l4jjb93l	269	14	%	%	NN
cord-334907-l4jjb93l	269	15	confluent	confluent	JJ
cord-334907-l4jjb93l	269	16	cell	cell	NN
cord-334907-l4jjb93l	269	17	monolayer	monolayer	NN
cord-334907-l4jjb93l	269	18	was	be	VBD
cord-334907-l4jjb93l	269	19	washed	wash	VBN
cord-334907-l4jjb93l	269	20	twice	twice	RB
cord-334907-l4jjb93l	269	21	with	with	IN
cord-334907-l4jjb93l	269	22	L-15	L-15	NNP
cord-334907-l4jjb93l	269	23	medium	medium	NN
cord-334907-l4jjb93l	269	24	and	and	CC
cord-334907-l4jjb93l	269	25	further	further	RB
cord-334907-l4jjb93l	269	26	covered	cover	VBN
cord-334907-l4jjb93l	269	27	with	with	IN
cord-334907-l4jjb93l	269	28	a	a	DT
cord-334907-l4jjb93l	269	29	viral	viral	JJ
cord-334907-l4jjb93l	269	30	dilution	dilution	NN
cord-334907-l4jjb93l	269	31	prepared	prepare	VBN
cord-334907-l4jjb93l	269	32	in	in	IN
cord-334907-l4jjb93l	269	33	L-15	L-15	NNP
cord-334907-l4jjb93l	269	34	medium	medium	NN
cord-334907-l4jjb93l	269	35	.	.	.
cord-334907-l4jjb93l	270	1	After	after	IN
cord-334907-l4jjb93l	270	2	4	4	CD
cord-334907-l4jjb93l	270	3	h	h	NN
cord-334907-l4jjb93l	270	4	of	of	IN
cord-334907-l4jjb93l	270	5	incubation	incubation	NN
cord-334907-l4jjb93l	270	6	,	,	,
cord-334907-l4jjb93l	270	7	the	the	DT
cord-334907-l4jjb93l	270	8	viral	viral	JJ
cord-334907-l4jjb93l	270	9	inoculum	inoculum	NN
cord-334907-l4jjb93l	270	10	was	be	VBD
cord-334907-l4jjb93l	270	11	removed	remove	VBN
cord-334907-l4jjb93l	270	12	,	,	,
cord-334907-l4jjb93l	270	13	and	and	CC
cord-334907-l4jjb93l	270	14	the	the	DT
cord-334907-l4jjb93l	270	15	cells	cell	NNS
cord-334907-l4jjb93l	270	16	were	be	VBD
cord-334907-l4jjb93l	270	17	washed	wash	VBN
cord-334907-l4jjb93l	270	18	twice	twice	RB
cord-334907-l4jjb93l	270	19	with	with	IN
cord-334907-l4jjb93l	270	20	L-15	L-15	NNP
cord-334907-l4jjb93l	270	21	medium	medium	NN
cord-334907-l4jjb93l	270	22	and	and	CC
cord-334907-l4jjb93l	270	23	further	further	RB
cord-334907-l4jjb93l	270	24	cultured	cultured	JJ
cord-334907-l4jjb93l	270	25	in	in	IN
cord-334907-l4jjb93l	270	26	L-15	L-15	NNP
cord-334907-l4jjb93l	270	27	medium	medium	NN
cord-334907-l4jjb93l	270	28	supplemented	supplement	VBN
cord-334907-l4jjb93l	270	29	with	with	IN
cord-334907-l4jjb93l	270	30	2	2	CD
cord-334907-l4jjb93l	270	31	%	%	NN
cord-334907-l4jjb93l	270	32	fetal	fetal	JJ
cord-334907-l4jjb93l	270	33	bovine	bovine	JJ
cord-334907-l4jjb93l	270	34	serum	serum	NN
cord-334907-l4jjb93l	270	35	and	and	CC
cord-334907-l4jjb93l	270	36	antibiotics	antibiotic	NNS
cord-334907-l4jjb93l	270	37	,	,	,
cord-334907-l4jjb93l	270	38	at	at	IN
cord-334907-l4jjb93l	270	39	17	17	CD
cord-334907-l4jjb93l	271	1	•	•	NNP
cord-334907-l4jjb93l	272	1	C.	C.	NNP
cord-334907-l4jjb93l	273	1	After	after	IN
cord-334907-l4jjb93l	273	2	7	7	CD
cord-334907-l4jjb93l	273	3	days	day	NNS
cord-334907-l4jjb93l	273	4	,	,	,
cord-334907-l4jjb93l	273	5	the	the	DT
cord-334907-l4jjb93l	273	6	cell	cell	NN
cord-334907-l4jjb93l	273	7	supernatant	supernatant	NN
cord-334907-l4jjb93l	273	8	was	be	VBD
cord-334907-l4jjb93l	273	9	recovered	recover	VBN
cord-334907-l4jjb93l	273	10	and	and	CC
cord-334907-l4jjb93l	273	11	filtered	filter	VBN
cord-334907-l4jjb93l	273	12	(	(	-LRB-
cord-334907-l4jjb93l	273	13	0.45	0.45	CD
cord-334907-l4jjb93l	273	14	µm	µm	CD
cord-334907-l4jjb93l	273	15	)	)	-RRB-
cord-334907-l4jjb93l	273	16	,	,	,
cord-334907-l4jjb93l	273	17	and	and	CC
cord-334907-l4jjb93l	273	18	viral	viral	JJ
cord-334907-l4jjb93l	273	19	aliquots	aliquot	NNS
cord-334907-l4jjb93l	273	20	were	be	VBD
cord-334907-l4jjb93l	273	21	collected	collect	VBN
cord-334907-l4jjb93l	273	22	and	and	CC
cord-334907-l4jjb93l	273	23	stored	store	VBN
cord-334907-l4jjb93l	273	24	at	at	IN
cord-334907-l4jjb93l	273	25	−80	−80	NNP
cord-334907-l4jjb93l	274	1	•	•	NNP
cord-334907-l4jjb93l	275	1	C.	C.	NNP
cord-334907-l4jjb93l	275	2	A	a	DT
cord-334907-l4jjb93l	275	3	plaque	plaque	NN
cord-334907-l4jjb93l	275	4	assay	assay	NN
cord-334907-l4jjb93l	275	5	was	be	VBD
cord-334907-l4jjb93l	275	6	used	use	VBN
cord-334907-l4jjb93l	275	7	for	for	IN
cord-334907-l4jjb93l	275	8	virus	virus	NN
cord-334907-l4jjb93l	275	9	tittering	titter	VBG
cord-334907-l4jjb93l	275	10	12	12	CD
cord-334907-l4jjb93l	275	11	days	day	NNS
cord-334907-l4jjb93l	275	12	post	post	NN
cord-334907-l4jjb93l	275	13	-	-	NN
cord-334907-l4jjb93l	275	14	infection	infection	JJ
cord-334907-l4jjb93l	275	15	(	(	-LRB-
cord-334907-l4jjb93l	275	16	d.p.i	d.p.i	NNP
cord-334907-l4jjb93l	275	17	.	.	.
cord-334907-l4jjb93l	275	18	)	)	-RRB-
cord-334907-l4jjb93l	275	19	,	,	,
cord-334907-l4jjb93l	275	20	as	as	IN
cord-334907-l4jjb93l	275	21	previously	previously	RB
cord-334907-l4jjb93l	275	22	described	describe	VBN
cord-334907-l4jjb93l	275	23	[	[	-LRB-
cord-334907-l4jjb93l	275	24	52	52	CD
cord-334907-l4jjb93l	275	25	]	]	-RRB-
cord-334907-l4jjb93l	275	26	.	.	.
cord-334907-l4jjb93l	276	1	Spodoptera	Spodoptera	NNP
cord-334907-l4jjb93l	276	2	frugiperda	frugiperda	NN
cord-334907-l4jjb93l	276	3	(	(	-LRB-
cord-334907-l4jjb93l	276	4	Sf21	sf21	NN
cord-334907-l4jjb93l	276	5	)	)	-RRB-
cord-334907-l4jjb93l	277	1	cells	cell	NNS
cord-334907-l4jjb93l	277	2	were	be	VBD
cord-334907-l4jjb93l	277	3	used	use	VBN
cord-334907-l4jjb93l	277	4	for	for	IN
cord-334907-l4jjb93l	277	5	recombinant	recombinant	JJ
cord-334907-l4jjb93l	277	6	baculovirus	baculovirus	NN
cord-334907-l4jjb93l	277	7	production	production	NN
cord-334907-l4jjb93l	277	8	and	and	CC
cord-334907-l4jjb93l	277	9	recombinant	recombinant	JJ
cord-334907-l4jjb93l	277	10	protein	protein	NN
cord-334907-l4jjb93l	277	11	expression	expression	NN
cord-334907-l4jjb93l	277	12	.	.	.
cord-334907-l4jjb93l	278	1	Cells	cell	NNS
cord-334907-l4jjb93l	278	2	were	be	VBD
cord-334907-l4jjb93l	278	3	grown	grow	VBN
cord-334907-l4jjb93l	278	4	in	in	IN
cord-334907-l4jjb93l	278	5	suspension	suspension	NN
cord-334907-l4jjb93l	278	6	culture	culture	NN
cord-334907-l4jjb93l	278	7	using	use	VBG
cord-334907-l4jjb93l	278	8	SF-900	SF-900	NNP
cord-334907-l4jjb93l	278	9	III	III	NNP
cord-334907-l4jjb93l	278	10	medium	medium	NN
cord-334907-l4jjb93l	278	11	(	(	-LRB-
cord-334907-l4jjb93l	278	12	Gibco	Gibco	NNP
cord-334907-l4jjb93l	278	13	)	)	-RRB-
cord-334907-l4jjb93l	278	14	supplemented	supplement	VBD
cord-334907-l4jjb93l	278	15	with	with	IN
cord-334907-l4jjb93l	278	16	1	1	CD
cord-334907-l4jjb93l	278	17	%	%	NN
cord-334907-l4jjb93l	278	18	fetal	fetal	JJ
cord-334907-l4jjb93l	278	19	bovine	bovine	JJ
cord-334907-l4jjb93l	278	20	serum	serum	NN
cord-334907-l4jjb93l	278	21	,	,	,
cord-334907-l4jjb93l	278	22	at	at	IN
cord-334907-l4jjb93l	278	23	28	28	CD
cord-334907-l4jjb93l	278	24	•	•	NNP
cord-334907-l4jjb93l	278	25	C.	C.	NNP
cord-334907-l4jjb93l	278	26	Suspension	Suspension	NNP
cord-334907-l4jjb93l	278	27	cells	cell	NNS
cord-334907-l4jjb93l	278	28	were	be	VBD
cord-334907-l4jjb93l	278	29	seeded	seed	VBN
cord-334907-l4jjb93l	278	30	at	at	IN
cord-334907-l4jjb93l	278	31	0.3	0.3	CD
cord-334907-l4jjb93l	278	32	×	×	CD
cord-334907-l4jjb93l	278	33	10	10	CD
cord-334907-l4jjb93l	278	34	6	6	CD
cord-334907-l4jjb93l	278	35	cells	cell	NNS
cord-334907-l4jjb93l	278	36	/	/	SYM
cord-334907-l4jjb93l	278	37	mL	ml	NN
cord-334907-l4jjb93l	278	38	,	,	,
cord-334907-l4jjb93l	278	39	agitated	agitate	VBN
cord-334907-l4jjb93l	278	40	at	at	IN
cord-334907-l4jjb93l	278	41	150	150	CD
cord-334907-l4jjb93l	278	42	rpm	rpm	NN
cord-334907-l4jjb93l	278	43	in	in	IN
cord-334907-l4jjb93l	278	44	500	500	CD
cord-334907-l4jjb93l	278	45	mL	ml	NN
cord-334907-l4jjb93l	278	46	flasks	flask	NNS
cord-334907-l4jjb93l	278	47	,	,	,
cord-334907-l4jjb93l	278	48	and	and	CC
cord-334907-l4jjb93l	278	49	subcultured	subculture	VBD
cord-334907-l4jjb93l	278	50	when	when	WRB
cord-334907-l4jjb93l	278	51	reaching	reach	VBG
cord-334907-l4jjb93l	278	52	(	(	-LRB-
cord-334907-l4jjb93l	278	53	8	8	CD
cord-334907-l4jjb93l	278	54	-	-	SYM
cord-334907-l4jjb93l	278	55	9	9	CD
cord-334907-l4jjb93l	278	56	)	)	-RRB-
cord-334907-l4jjb93l	278	57	×	×	CD
cord-334907-l4jjb93l	278	58	10	10	CD
cord-334907-l4jjb93l	278	59	6	6	CD
cord-334907-l4jjb93l	278	60	cells	cell	NNS
cord-334907-l4jjb93l	278	61	/	/	SYM
cord-334907-l4jjb93l	278	62	mL.	mL.	NNS
cord-334907-l4jjb93l	278	63	Recombinant	recombinant	JJ
cord-334907-l4jjb93l	278	64	baculovirus	baculovirus	NNP
cord-334907-l4jjb93l	278	65	were	be	VBD
cord-334907-l4jjb93l	278	66	developed	develop	VBN
cord-334907-l4jjb93l	278	67	for	for	IN
cord-334907-l4jjb93l	278	68	the	the	DT
cord-334907-l4jjb93l	278	69	expression	expression	NN
cord-334907-l4jjb93l	278	70	and	and	CC
cord-334907-l4jjb93l	278	71	purification	purification	NN
cord-334907-l4jjb93l	278	72	of	of	IN
cord-334907-l4jjb93l	278	73	the	the	DT
cord-334907-l4jjb93l	278	74	extracellular	extracellular	JJ
cord-334907-l4jjb93l	278	75	domains	domain	NNS
cord-334907-l4jjb93l	278	76	of	of	IN
cord-334907-l4jjb93l	278	77	ISAV	ISAV	NNP
cord-334907-l4jjb93l	278	78	HE	HE	NNP
cord-334907-l4jjb93l	278	79	and	and	CC
cord-334907-l4jjb93l	278	80	F	F	NNP
cord-334907-l4jjb93l	278	81	proteins	protein	NNS
cord-334907-l4jjb93l	278	82	,	,	,
cord-334907-l4jjb93l	278	83	using	use	VBG
cord-334907-l4jjb93l	278	84	the	the	DT
cord-334907-l4jjb93l	278	85	baculovirus	baculovirus	NN
cord-334907-l4jjb93l	278	86	/	/	SYM
cord-334907-l4jjb93l	278	87	Sf21	sf21	NN
cord-334907-l4jjb93l	278	88	cells	cell	NNS
cord-334907-l4jjb93l	278	89	expression	expression	NN
cord-334907-l4jjb93l	278	90	system	system	NN
cord-334907-l4jjb93l	278	91	,	,	,
cord-334907-l4jjb93l	278	92	as	as	IN
cord-334907-l4jjb93l	278	93	previously	previously	RB
cord-334907-l4jjb93l	278	94	described	describe	VBN
cord-334907-l4jjb93l	278	95	by	by	IN
cord-334907-l4jjb93l	278	96	Ojeda	Ojeda	NNP
cord-334907-l4jjb93l	278	97	et	et	NNP
cord-334907-l4jjb93l	278	98	al	al	NNP
cord-334907-l4jjb93l	278	99	.	.	.
cord-334907-l4jjb93l	279	1	[	[	-LRB-
cord-334907-l4jjb93l	279	2	35	35	CD
cord-334907-l4jjb93l	279	3	]	]	-RRB-
cord-334907-l4jjb93l	279	4	.	.	.
cord-334907-l4jjb93l	280	1	For	for	IN
cord-334907-l4jjb93l	280	2	recombinant	recombinant	JJ
cord-334907-l4jjb93l	280	3	protein	protein	NN
cord-334907-l4jjb93l	280	4	production	production	NN
cord-334907-l4jjb93l	280	5	,	,	,
cord-334907-l4jjb93l	280	6	a	a	DT
cord-334907-l4jjb93l	280	7	suspension	suspension	NN
cord-334907-l4jjb93l	280	8	culture	culture	NN
cord-334907-l4jjb93l	280	9	of	of	IN
cord-334907-l4jjb93l	280	10	300	300	CD
cord-334907-l4jjb93l	280	11	mL	ml	NN
cord-334907-l4jjb93l	280	12	of	of	IN
cord-334907-l4jjb93l	280	13	Sf21	sf21	JJ
cord-334907-l4jjb93l	280	14	cells	cell	NNS
cord-334907-l4jjb93l	280	15	at	at	IN
cord-334907-l4jjb93l	280	16	6	6	CD
cord-334907-l4jjb93l	280	17	×	×	NN
cord-334907-l4jjb93l	280	18	10	10	CD
cord-334907-l4jjb93l	280	19	6	6	CD
cord-334907-l4jjb93l	280	20	/mL	/mL	:
cord-334907-l4jjb93l	280	21	was	be	VBD
cord-334907-l4jjb93l	280	22	infected	infect	VBN
cord-334907-l4jjb93l	280	23	using	use	VBG
cord-334907-l4jjb93l	280	24	a	a	DT
cord-334907-l4jjb93l	280	25	multiplicity	multiplicity	NN
cord-334907-l4jjb93l	280	26	of	of	IN
cord-334907-l4jjb93l	280	27	infection	infection	NN
cord-334907-l4jjb93l	280	28	(	(	-LRB-
cord-334907-l4jjb93l	280	29	MOI	MOI	NNP
cord-334907-l4jjb93l	280	30	)	)	-RRB-
cord-334907-l4jjb93l	280	31	of	of	IN
cord-334907-l4jjb93l	280	32	10	10	CD
cord-334907-l4jjb93l	280	33	.	.	.
cord-334907-l4jjb93l	281	1	After	after	IN
cord-334907-l4jjb93l	281	2	120	120	CD
cord-334907-l4jjb93l	281	3	h	h	NN
cord-334907-l4jjb93l	281	4	culture	culture	NN
cord-334907-l4jjb93l	281	5	at	at	IN
cord-334907-l4jjb93l	281	6	23	23	CD
cord-334907-l4jjb93l	281	7	•	•	NN
cord-334907-l4jjb93l	281	8	C	c	NN
cord-334907-l4jjb93l	281	9	,	,	,
cord-334907-l4jjb93l	281	10	Sf21	Sf21	NNP
cord-334907-l4jjb93l	282	1	cells	cell	NNS
cord-334907-l4jjb93l	282	2	were	be	VBD
cord-334907-l4jjb93l	282	3	pelleted	pellete	VBN
cord-334907-l4jjb93l	282	4	at	at	IN
cord-334907-l4jjb93l	282	5	500×	500×	CD
cord-334907-l4jjb93l	282	6	g	g	NN
cord-334907-l4jjb93l	282	7	,	,	,
cord-334907-l4jjb93l	282	8	washed	wash	VBN
cord-334907-l4jjb93l	282	9	twice	twice	RB
cord-334907-l4jjb93l	282	10	with	with	IN
cord-334907-l4jjb93l	282	11	Grace	Grace	NNP
cord-334907-l4jjb93l	282	12	's	's	POS
cord-334907-l4jjb93l	282	13	Insect	Insect	NNP
cord-334907-l4jjb93l	282	14	Medium	Medium	NNP
cord-334907-l4jjb93l	282	15	,	,	,
cord-334907-l4jjb93l	282	16	and	and	CC
cord-334907-l4jjb93l	282	17	then	then	RB
cord-334907-l4jjb93l	282	18	suspended	suspend	VBN
cord-334907-l4jjb93l	282	19	in	in	IN
cord-334907-l4jjb93l	282	20	lysis	lysis	NN
cord-334907-l4jjb93l	282	21	buffer	buffer	NN
cord-334907-l4jjb93l	282	22	(	(	-LRB-
cord-334907-l4jjb93l	282	23	50	50	CD
cord-334907-l4jjb93l	282	24	mM	mM	NNP
cord-334907-l4jjb93l	282	25	Tris	Tris	NNP
cord-334907-l4jjb93l	282	26	-	-	HYPH
cord-334907-l4jjb93l	282	27	HCl	HCl	NNP
cord-334907-l4jjb93l	282	28	pH	pH	NNP
cord-334907-l4jjb93l	282	29	7.4	7.4	CD
cord-334907-l4jjb93l	282	30	,	,	,
cord-334907-l4jjb93l	282	31	150	150	CD
cord-334907-l4jjb93l	282	32	mM	mm	CD
cord-334907-l4jjb93l	282	33	NaCl	nacl	NN
cord-334907-l4jjb93l	282	34	,	,	,
cord-334907-l4jjb93l	282	35	1mM	1mm	CD
cord-334907-l4jjb93l	282	36	EDTA	EDTA	NNP
cord-334907-l4jjb93l	282	37	,	,	,
cord-334907-l4jjb93l	282	38	and	and	CC
cord-334907-l4jjb93l	282	39	1	1	CD
cord-334907-l4jjb93l	282	40	%	%	NN
cord-334907-l4jjb93l	282	41	Triton	Triton	NNP
cord-334907-l4jjb93l	282	42	X-100	x-100	NN
cord-334907-l4jjb93l	282	43	)	)	-RRB-
cord-334907-l4jjb93l	282	44	.	.	.
cord-334907-l4jjb93l	283	1	After	after	IN
cord-334907-l4jjb93l	283	2	a	a	DT
cord-334907-l4jjb93l	283	3	2	2	CD
cord-334907-l4jjb93l	283	4	h	h	NN
cord-334907-l4jjb93l	283	5	incubation	incubation	NN
cord-334907-l4jjb93l	283	6	on	on	IN
cord-334907-l4jjb93l	283	7	ice	ice	NN
cord-334907-l4jjb93l	283	8	,	,	,
cord-334907-l4jjb93l	283	9	samples	sample	NNS
cord-334907-l4jjb93l	283	10	were	be	VBD
cord-334907-l4jjb93l	283	11	sonicated	sonicate	VBN
cord-334907-l4jjb93l	283	12	using	use	VBG
cord-334907-l4jjb93l	283	13	20	20	CD
cord-334907-l4jjb93l	283	14	%	%	NN
cord-334907-l4jjb93l	283	15	of	of	IN
cord-334907-l4jjb93l	283	16	amplitude	amplitude	NN
cord-334907-l4jjb93l	283	17	in	in	IN
cord-334907-l4jjb93l	283	18	five	five	CD
cord-334907-l4jjb93l	283	19	30	30	CD
cord-334907-l4jjb93l	283	20	s	s	POS
cord-334907-l4jjb93l	283	21	repetitions	repetition	NNS
cord-334907-l4jjb93l	283	22	,	,	,
cord-334907-l4jjb93l	283	23	with	with	IN
cord-334907-l4jjb93l	283	24	30	30	CD
cord-334907-l4jjb93l	283	25	s	s	NNS
cord-334907-l4jjb93l	283	26	of	of	IN
cord-334907-l4jjb93l	283	27	cooling	cool	VBG
cord-334907-l4jjb93l	283	28	between	between	IN
cord-334907-l4jjb93l	283	29	each	each	DT
cord-334907-l4jjb93l	283	30	repetition	repetition	NN
cord-334907-l4jjb93l	283	31	.	.	.
cord-334907-l4jjb93l	284	1	Samples	sample	NNS
cord-334907-l4jjb93l	284	2	were	be	VBD
cord-334907-l4jjb93l	284	3	then	then	RB
cord-334907-l4jjb93l	284	4	centrifuged	centrifuge	VBN
cord-334907-l4jjb93l	284	5	at	at	IN
cord-334907-l4jjb93l	284	6	12,500×	12,500×	CD
cord-334907-l4jjb93l	284	7	g	g	NN
cord-334907-l4jjb93l	284	8	for	for	IN
cord-334907-l4jjb93l	284	9	30	30	CD
cord-334907-l4jjb93l	284	10	min	min	NN
cord-334907-l4jjb93l	284	11	to	to	TO
cord-334907-l4jjb93l	284	12	remove	remove	VB
cord-334907-l4jjb93l	284	13	cell	cell	NN
cord-334907-l4jjb93l	284	14	debris	debris	NN
cord-334907-l4jjb93l	284	15	.	.	.
cord-334907-l4jjb93l	285	1	The	the	DT
cord-334907-l4jjb93l	285	2	supernatant	supernatant	NN
cord-334907-l4jjb93l	285	3	,	,	,
cord-334907-l4jjb93l	285	4	containing	contain	VBG
cord-334907-l4jjb93l	285	5	the	the	DT
cord-334907-l4jjb93l	285	6	recombinant	recombinant	JJ
cord-334907-l4jjb93l	285	7	proteins	protein	NNS
cord-334907-l4jjb93l	285	8	,	,	,
cord-334907-l4jjb93l	285	9	was	be	VBD
cord-334907-l4jjb93l	285	10	filtered	filter	VBN
cord-334907-l4jjb93l	285	11	(	(	-LRB-
cord-334907-l4jjb93l	285	12	0.45	0.45	CD
cord-334907-l4jjb93l	285	13	µm	µm	CD
cord-334907-l4jjb93l	285	14	)	)	-RRB-
cord-334907-l4jjb93l	285	15	using	use	VBG
cord-334907-l4jjb93l	285	16	a	a	DT
cord-334907-l4jjb93l	285	17	low	low	JJ
cord-334907-l4jjb93l	285	18	-	-	HYPH
cord-334907-l4jjb93l	285	19	protein	protein	NN
cord-334907-l4jjb93l	285	20	-	-	HYPH
cord-334907-l4jjb93l	285	21	binding	bind	VBG
cord-334907-l4jjb93l	285	22	filter	filter	NN
cord-334907-l4jjb93l	285	23	(	(	-LRB-
cord-334907-l4jjb93l	285	24	Millipore	Millipore	NNP
cord-334907-l4jjb93l	285	25	,	,	,
cord-334907-l4jjb93l	285	26	Burlington	Burlington	NNP
cord-334907-l4jjb93l	285	27	,	,	,
cord-334907-l4jjb93l	285	28	USA	USA	NNP
cord-334907-l4jjb93l	285	29	)	)	-RRB-
cord-334907-l4jjb93l	285	30	.	.	.
cord-334907-l4jjb93l	286	1	Recombinant	recombinant	JJ
cord-334907-l4jjb93l	286	2	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	286	3	esterase	esterase	NN
cord-334907-l4jjb93l	286	4	and	and	CC
cord-334907-l4jjb93l	286	5	fusion	fusion	NN
cord-334907-l4jjb93l	286	6	proteins	protein	NNS
cord-334907-l4jjb93l	286	7	(	(	-LRB-
cord-334907-l4jjb93l	286	8	rHE	rHE	NNP
cord-334907-l4jjb93l	286	9	and	and	CC
cord-334907-l4jjb93l	286	10	rF	rF	NNP
cord-334907-l4jjb93l	286	11	)	)	-RRB-
cord-334907-l4jjb93l	286	12	were	be	VBD
cord-334907-l4jjb93l	286	13	purified	purify	VBN
cord-334907-l4jjb93l	286	14	using	use	VBG
cord-334907-l4jjb93l	286	15	the	the	DT
cord-334907-l4jjb93l	286	16	anti	anti	JJ
cord-334907-l4jjb93l	286	17	-	-	JJ
cord-334907-l4jjb93l	286	18	FLAG	flag	JJ
cord-334907-l4jjb93l	286	19	M2	M2	NNP
cord-334907-l4jjb93l	286	20	Magnetic	Magnetic	NNP
cord-334907-l4jjb93l	286	21	Beads	Beads	NNPS
cord-334907-l4jjb93l	286	22	System	System	NNP
cord-334907-l4jjb93l	286	23	(	(	-LRB-
cord-334907-l4jjb93l	286	24	Sigma	Sigma	NNP
cord-334907-l4jjb93l	286	25	-	-	HYPH
cord-334907-l4jjb93l	286	26	Aldrich	Aldrich	NNP
cord-334907-l4jjb93l	286	27	,	,	,
cord-334907-l4jjb93l	286	28	St.	St.	NNP
cord-334907-l4jjb93l	286	29	Louis	Louis	NNP
cord-334907-l4jjb93l	286	30	,	,	,
cord-334907-l4jjb93l	286	31	Missouri	Missouri	NNP
cord-334907-l4jjb93l	286	32	,	,	,
cord-334907-l4jjb93l	286	33	USA	USA	NNP
cord-334907-l4jjb93l	286	34	)	)	-RRB-
cord-334907-l4jjb93l	286	35	and	and	CC
cord-334907-l4jjb93l	286	36	the	the	DT
cord-334907-l4jjb93l	286	37	Magnetight	Magnetight	NNP
cord-334907-l4jjb93l	286	38	Separator	Separator	NNP
cord-334907-l4jjb93l	286	39	Stand	Stand	NNP
cord-334907-l4jjb93l	286	40	(	(	-LRB-
cord-334907-l4jjb93l	286	41	Novagen	Novagen	NNP
cord-334907-l4jjb93l	286	42	,	,	,
cord-334907-l4jjb93l	286	43	Darmstadt	Darmstadt	NNP
cord-334907-l4jjb93l	286	44	,	,	,
cord-334907-l4jjb93l	286	45	Germany	Germany	NNP
cord-334907-l4jjb93l	286	46	)	)	-RRB-
cord-334907-l4jjb93l	286	47	according	accord	VBG
cord-334907-l4jjb93l	286	48	to	to	IN
cord-334907-l4jjb93l	286	49	the	the	DT
cord-334907-l4jjb93l	286	50	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	286	51	's	's	POS
cord-334907-l4jjb93l	286	52	instructions	instruction	NNS
cord-334907-l4jjb93l	286	53	.	.	.
cord-334907-l4jjb93l	287	1	Protein	protein	NN
cord-334907-l4jjb93l	287	2	concentration	concentration	NN
cord-334907-l4jjb93l	287	3	for	for	IN
cord-334907-l4jjb93l	287	4	each	each	DT
cord-334907-l4jjb93l	287	5	sample	sample	NN
cord-334907-l4jjb93l	287	6	was	be	VBD
cord-334907-l4jjb93l	287	7	measured	measure	VBN
cord-334907-l4jjb93l	287	8	using	use	VBG
cord-334907-l4jjb93l	287	9	the	the	DT
cord-334907-l4jjb93l	287	10	BCA	BCA	NNP
cord-334907-l4jjb93l	287	11	Assay	Assay	NNP
cord-334907-l4jjb93l	287	12	Kit	Kit	NNP
cord-334907-l4jjb93l	287	13	and	and	CC
cord-334907-l4jjb93l	287	14	BSA	BSA	NNP
cord-334907-l4jjb93l	287	15	standard	standard	NN
cord-334907-l4jjb93l	287	16	(	(	-LRB-
cord-334907-l4jjb93l	287	17	Pierce	Pierce	NNP
cord-334907-l4jjb93l	287	18	,	,	,
cord-334907-l4jjb93l	287	19	Waltham	Waltham	NNP
cord-334907-l4jjb93l	287	20	,	,	,
cord-334907-l4jjb93l	287	21	MA	MA	NNP
cord-334907-l4jjb93l	287	22	,	,	,
cord-334907-l4jjb93l	287	23	USA	USA	NNP
cord-334907-l4jjb93l	287	24	)	)	-RRB-
cord-334907-l4jjb93l	287	25	.	.	.
cord-334907-l4jjb93l	288	1	Approximately	approximately	RB
cord-334907-l4jjb93l	288	2	20	20	CD
cord-334907-l4jjb93l	288	3	µg	µg	NN
cord-334907-l4jjb93l	288	4	of	of	IN
cord-334907-l4jjb93l	288	5	each	each	DT
cord-334907-l4jjb93l	288	6	protein	protein	NN
cord-334907-l4jjb93l	288	7	was	be	VBD
cord-334907-l4jjb93l	288	8	obtained	obtain	VBN
cord-334907-l4jjb93l	288	9	from	from	IN
cord-334907-l4jjb93l	288	10	the	the	DT
cord-334907-l4jjb93l	288	11	infected	infect	VBN
cord-334907-l4jjb93l	288	12	Sf21	sf21	NN
cord-334907-l4jjb93l	289	1	cells	cell	NNS
cord-334907-l4jjb93l	289	2	.	.	.
cord-334907-l4jjb93l	290	1	ASK	ask	VB
cord-334907-l4jjb93l	290	2	cells	cell	NNS
cord-334907-l4jjb93l	290	3	were	be	VBD
cord-334907-l4jjb93l	290	4	seeded	seed	VBN
cord-334907-l4jjb93l	290	5	on	on	IN
cord-334907-l4jjb93l	290	6	35	35	CD
cord-334907-l4jjb93l	290	7	mm	mm	CD
cord-334907-l4jjb93l	290	8	2	2	CD
cord-334907-l4jjb93l	290	9	glass	glass	NN
cord-334907-l4jjb93l	290	10	bottom	bottom	NN
cord-334907-l4jjb93l	290	11	dishes	dish	NNS
cord-334907-l4jjb93l	290	12	(	(	-LRB-
cord-334907-l4jjb93l	290	13	2	2	CD
cord-334907-l4jjb93l	290	14	×	×	NN
cord-334907-l4jjb93l	290	15	10	10	CD
cord-334907-l4jjb93l	290	16	5	5	CD
cord-334907-l4jjb93l	290	17	cells	cell	NNS
cord-334907-l4jjb93l	290	18	)	)	-RRB-
cord-334907-l4jjb93l	290	19	.	.	.
cord-334907-l4jjb93l	291	1	Following	follow	VBG
cord-334907-l4jjb93l	291	2	a	a	DT
cord-334907-l4jjb93l	291	3	12	12	CD
cord-334907-l4jjb93l	291	4	h	h	NN
cord-334907-l4jjb93l	291	5	incubation	incubation	NN
cord-334907-l4jjb93l	291	6	,	,	,
cord-334907-l4jjb93l	291	7	the	the	DT
cord-334907-l4jjb93l	291	8	cells	cell	NNS
cord-334907-l4jjb93l	291	9	were	be	VBD
cord-334907-l4jjb93l	291	10	fixed	fix	VBN
cord-334907-l4jjb93l	291	11	with	with	IN
cord-334907-l4jjb93l	291	12	fresh	fresh	JJ
cord-334907-l4jjb93l	291	13	4	4	CD
cord-334907-l4jjb93l	291	14	%	%	NN
cord-334907-l4jjb93l	291	15	paraformaldehyde	paraformaldehyde	NN
cord-334907-l4jjb93l	291	16	in	in	IN
cord-334907-l4jjb93l	291	17	phosphate	phosphate	NN
cord-334907-l4jjb93l	291	18	-	-	HYPH
cord-334907-l4jjb93l	291	19	buffered	buffer	VBN
cord-334907-l4jjb93l	291	20	saline	saline	NN
cord-334907-l4jjb93l	291	21	(	(	-LRB-
cord-334907-l4jjb93l	291	22	PBS	PBS	NNP
cord-334907-l4jjb93l	291	23	)	)	-RRB-
cord-334907-l4jjb93l	291	24	for	for	IN
cord-334907-l4jjb93l	291	25	15	15	CD
cord-334907-l4jjb93l	291	26	min	min	NN
cord-334907-l4jjb93l	291	27	.	.	.
cord-334907-l4jjb93l	292	1	Then	then	RB
cord-334907-l4jjb93l	292	2	,	,	,
cord-334907-l4jjb93l	292	3	cells	cell	NNS
cord-334907-l4jjb93l	292	4	were	be	VBD
cord-334907-l4jjb93l	292	5	washed	wash	VBN
cord-334907-l4jjb93l	292	6	twice	twice	RB
cord-334907-l4jjb93l	292	7	with	with	IN
cord-334907-l4jjb93l	292	8	PBS	PBS	NNP
cord-334907-l4jjb93l	292	9	and	and	CC
cord-334907-l4jjb93l	292	10	treated	treat	VBN
cord-334907-l4jjb93l	292	11	with	with	IN
cord-334907-l4jjb93l	292	12	a	a	DT
cord-334907-l4jjb93l	292	13	blocking	block	VBG
cord-334907-l4jjb93l	292	14	buffer	buffer	NN
cord-334907-l4jjb93l	292	15	(	(	-LRB-
cord-334907-l4jjb93l	292	16	1	1	CD
cord-334907-l4jjb93l	292	17	%	%	NN
cord-334907-l4jjb93l	292	18	BSA	BSA	NNP
cord-334907-l4jjb93l	292	19	and	and	CC
cord-334907-l4jjb93l	292	20	0.3	0.3	CD
cord-334907-l4jjb93l	292	21	%	%	NN
cord-334907-l4jjb93l	292	22	Triton	Triton	NNP
cord-334907-l4jjb93l	292	23	X-100	x-100	NN
cord-334907-l4jjb93l	292	24	in	in	IN
cord-334907-l4jjb93l	292	25	PBS	PBS	NNP
cord-334907-l4jjb93l	292	26	)	)	-RRB-
cord-334907-l4jjb93l	292	27	for	for	IN
cord-334907-l4jjb93l	292	28	30	30	CD
cord-334907-l4jjb93l	292	29	min	min	NN
cord-334907-l4jjb93l	292	30	.	.	.
cord-334907-l4jjb93l	293	1	After	after	IN
cord-334907-l4jjb93l	293	2	the	the	DT
cord-334907-l4jjb93l	293	3	buffer	buffer	NN
cord-334907-l4jjb93l	293	4	was	be	VBD
cord-334907-l4jjb93l	293	5	removed	remove	VBN
cord-334907-l4jjb93l	293	6	,	,	,
cord-334907-l4jjb93l	293	7	50	50	CD
cord-334907-l4jjb93l	293	8	ng	ng	NN
cord-334907-l4jjb93l	293	9	of	of	IN
cord-334907-l4jjb93l	293	10	rHE	rHE	NNP
cord-334907-l4jjb93l	293	11	or	or	CC
cord-334907-l4jjb93l	293	12	rF	rF	NNP
cord-334907-l4jjb93l	293	13	,	,	,
cord-334907-l4jjb93l	293	14	diluted	dilute	VBN
cord-334907-l4jjb93l	293	15	in	in	IN
cord-334907-l4jjb93l	293	16	blocking	block	VBG
cord-334907-l4jjb93l	293	17	buffer	buffer	NN
cord-334907-l4jjb93l	293	18	,	,	,
cord-334907-l4jjb93l	293	19	was	be	VBD
cord-334907-l4jjb93l	293	20	added	add	VBN
cord-334907-l4jjb93l	293	21	to	to	IN
cord-334907-l4jjb93l	293	22	the	the	DT
cord-334907-l4jjb93l	293	23	cells	cell	NNS
cord-334907-l4jjb93l	293	24	,	,	,
cord-334907-l4jjb93l	293	25	followed	follow	VBN
cord-334907-l4jjb93l	293	26	by	by	IN
cord-334907-l4jjb93l	293	27	incubation	incubation	NN
cord-334907-l4jjb93l	293	28	for	for	IN
cord-334907-l4jjb93l	293	29	1	1	CD
cord-334907-l4jjb93l	293	30	h.	h.	NN
cord-334907-l4jjb93l	294	1	To	to	TO
cord-334907-l4jjb93l	294	2	analyze	analyze	VB
cord-334907-l4jjb93l	294	3	the	the	DT
cord-334907-l4jjb93l	294	4	influence	influence	NN
cord-334907-l4jjb93l	294	5	of	of	IN
cord-334907-l4jjb93l	294	6	HE	he	PRP
cord-334907-l4jjb93l	294	7	over	over	IN
cord-334907-l4jjb93l	294	8	the	the	DT
cord-334907-l4jjb93l	294	9	interaction	interaction	NN
cord-334907-l4jjb93l	294	10	of	of	IN
cord-334907-l4jjb93l	294	11	F	F	NNP
cord-334907-l4jjb93l	294	12	with	with	IN
cord-334907-l4jjb93l	294	13	a	a	DT
cord-334907-l4jjb93l	294	14	cell	cell	NN
cord-334907-l4jjb93l	294	15	receptor	receptor	NN
cord-334907-l4jjb93l	294	16	,	,	,
cord-334907-l4jjb93l	294	17	rHE	rHE	NNP
cord-334907-l4jjb93l	294	18	was	be	VBD
cord-334907-l4jjb93l	294	19	pretreated	pretreate	VBN
cord-334907-l4jjb93l	294	20	with	with	IN
cord-334907-l4jjb93l	294	21	10	10	CD
cord-334907-l4jjb93l	294	22	µM	µM	NNP
cord-334907-l4jjb93l	294	23	DCIC	DCIC	NNP
cord-334907-l4jjb93l	294	24	(	(	-LRB-
cord-334907-l4jjb93l	294	25	Sigma	Sigma	NNP
cord-334907-l4jjb93l	294	26	-	-	HYPH
cord-334907-l4jjb93l	294	27	Aldrich	Aldrich	NNP
cord-334907-l4jjb93l	294	28	,	,	,
cord-334907-l4jjb93l	294	29	St.	St.	NNP
cord-334907-l4jjb93l	294	30	Louis	Louis	NNP
cord-334907-l4jjb93l	294	31	,	,	,
cord-334907-l4jjb93l	294	32	Missouri	Missouri	NNP
cord-334907-l4jjb93l	294	33	,	,	,
cord-334907-l4jjb93l	294	34	USA	USA	NNP
cord-334907-l4jjb93l	294	35	)	)	-RRB-
cord-334907-l4jjb93l	294	36	for	for	IN
cord-334907-l4jjb93l	294	37	30	30	CD
cord-334907-l4jjb93l	294	38	min	min	NN
cord-334907-l4jjb93l	294	39	before	before	IN
cord-334907-l4jjb93l	294	40	incubating	incubate	VBG
cord-334907-l4jjb93l	294	41	the	the	DT
cord-334907-l4jjb93l	294	42	cells	cell	NNS
cord-334907-l4jjb93l	294	43	with	with	IN
cord-334907-l4jjb93l	294	44	the	the	DT
cord-334907-l4jjb93l	294	45	recombinant	recombinant	JJ
cord-334907-l4jjb93l	294	46	lectin	lectin	NN
cord-334907-l4jjb93l	294	47	for	for	IN
cord-334907-l4jjb93l	294	48	1	1	CD
cord-334907-l4jjb93l	294	49	h	h	NN
cord-334907-l4jjb93l	294	50	[	[	-LRB-
cord-334907-l4jjb93l	294	51	53	53	CD
cord-334907-l4jjb93l	294	52	]	]	-RRB-
cord-334907-l4jjb93l	294	53	.	.	.
cord-334907-l4jjb93l	295	1	After	after	IN
cord-334907-l4jjb93l	295	2	three	three	CD
cord-334907-l4jjb93l	295	3	PBS	PBS	NNP
cord-334907-l4jjb93l	295	4	washes	wash	NNS
cord-334907-l4jjb93l	295	5	,	,	,
cord-334907-l4jjb93l	295	6	50	50	CD
cord-334907-l4jjb93l	295	7	ng	ng	NN
cord-334907-l4jjb93l	295	8	of	of	IN
cord-334907-l4jjb93l	295	9	rF	rF	NNP
cord-334907-l4jjb93l	295	10	were	be	VBD
cord-334907-l4jjb93l	295	11	added	add	VBN
cord-334907-l4jjb93l	295	12	and	and	CC
cord-334907-l4jjb93l	295	13	incubated	incubate	VBN
cord-334907-l4jjb93l	295	14	as	as	IN
cord-334907-l4jjb93l	295	15	described	describe	VBN
cord-334907-l4jjb93l	295	16	above	above	RB
cord-334907-l4jjb93l	295	17	;	;	:
cord-334907-l4jjb93l	295	18	a	a	DT
cord-334907-l4jjb93l	295	19	DMSO	DMSO	NNP
cord-334907-l4jjb93l	295	20	-	-	HYPH
cord-334907-l4jjb93l	295	21	treated	treat	VBN
cord-334907-l4jjb93l	295	22	aliquot	aliquot	NN
cord-334907-l4jjb93l	295	23	of	of	IN
cord-334907-l4jjb93l	295	24	rHE	rHE	NNP
cord-334907-l4jjb93l	295	25	was	be	VBD
cord-334907-l4jjb93l	295	26	used	use	VBN
cord-334907-l4jjb93l	295	27	as	as	IN
cord-334907-l4jjb93l	295	28	control	control	NN
cord-334907-l4jjb93l	295	29	.	.	.
cord-334907-l4jjb93l	296	1	ASK	ask	VB
cord-334907-l4jjb93l	296	2	cells	cell	NNS
cord-334907-l4jjb93l	296	3	were	be	VBD
cord-334907-l4jjb93l	296	4	treated	treat	VBN
cord-334907-l4jjb93l	296	5	with	with	IN
cord-334907-l4jjb93l	296	6	0.1	0.1	CD
cord-334907-l4jjb93l	296	7	M	m	NN
cord-334907-l4jjb93l	296	8	NaOH	NaOH	NNP
cord-334907-l4jjb93l	296	9	for	for	IN
cord-334907-l4jjb93l	296	10	30	30	CD
cord-334907-l4jjb93l	296	11	min	min	NN
cord-334907-l4jjb93l	296	12	for	for	IN
cord-334907-l4jjb93l	296	13	saponification	saponification	NN
cord-334907-l4jjb93l	296	14	.	.	.
cord-334907-l4jjb93l	297	1	This	this	DT
cord-334907-l4jjb93l	297	2	procedure	procedure	NN
cord-334907-l4jjb93l	297	3	results	result	NNS
cord-334907-l4jjb93l	297	4	in	in	IN
cord-334907-l4jjb93l	297	5	the	the	DT
cord-334907-l4jjb93l	297	6	de	de	JJ
cord-334907-l4jjb93l	297	7	-	-	HYPH
cord-334907-l4jjb93l	297	8	O	o	NN
cord-334907-l4jjb93l	297	9	-	-	HYPH
cord-334907-l4jjb93l	297	10	acetylation	acetylation	NN
cord-334907-l4jjb93l	297	11	of	of	IN
cord-334907-l4jjb93l	297	12	sialic	sialic	JJ
cord-334907-l4jjb93l	297	13	acids	acid	NNS
cord-334907-l4jjb93l	297	14	,	,	,
cord-334907-l4jjb93l	297	15	prior	prior	RB
cord-334907-l4jjb93l	297	16	to	to	IN
cord-334907-l4jjb93l	297	17	the	the	DT
cord-334907-l4jjb93l	297	18	lectin	lectin	NN
cord-334907-l4jjb93l	297	19	incubation	incubation	NN
cord-334907-l4jjb93l	297	20	step	step	NN
cord-334907-l4jjb93l	297	21	,	,	,
cord-334907-l4jjb93l	297	22	to	to	TO
cord-334907-l4jjb93l	297	23	evaluate	evaluate	VB
cord-334907-l4jjb93l	297	24	the	the	DT
cord-334907-l4jjb93l	297	25	interaction	interaction	NN
cord-334907-l4jjb93l	297	26	of	of	IN
cord-334907-l4jjb93l	297	27	rF	rf	NN
cord-334907-l4jjb93l	297	28	with	with	IN
cord-334907-l4jjb93l	297	29	sialic	sialic	JJ
cord-334907-l4jjb93l	297	30	acids	acid	NNS
cord-334907-l4jjb93l	297	31	on	on	IN
cord-334907-l4jjb93l	297	32	the	the	DT
cord-334907-l4jjb93l	297	33	cell	cell	NN
cord-334907-l4jjb93l	297	34	[	[	-LRB-
cord-334907-l4jjb93l	297	35	27	27	CD
cord-334907-l4jjb93l	297	36	]	]	-RRB-
cord-334907-l4jjb93l	297	37	.	.	.
cord-334907-l4jjb93l	298	1	As	as	IN
cord-334907-l4jjb93l	298	2	a	a	DT
cord-334907-l4jjb93l	298	3	negative	negative	JJ
cord-334907-l4jjb93l	298	4	control	control	NN
cord-334907-l4jjb93l	298	5	,	,	,
cord-334907-l4jjb93l	298	6	ASK	ask	VB
cord-334907-l4jjb93l	298	7	cells	cell	NNS
cord-334907-l4jjb93l	298	8	were	be	VBD
cord-334907-l4jjb93l	298	9	incubated	incubate	VBN
cord-334907-l4jjb93l	298	10	with	with	IN
cord-334907-l4jjb93l	298	11	a	a	DT
cord-334907-l4jjb93l	298	12	protein	protein	NN
cord-334907-l4jjb93l	298	13	extract	extract	NN
cord-334907-l4jjb93l	298	14	from	from	IN
cord-334907-l4jjb93l	298	15	Sf21	Sf21	NNP
cord-334907-l4jjb93l	299	1	cells	cell	NNS
cord-334907-l4jjb93l	299	2	(	(	-LRB-
cord-334907-l4jjb93l	299	3	1	1	CD
cord-334907-l4jjb93l	299	4	µg	µg	NN
cord-334907-l4jjb93l	299	5	of	of	IN
cord-334907-l4jjb93l	299	6	total	total	JJ
cord-334907-l4jjb93l	299	7	protein	protein	NN
cord-334907-l4jjb93l	299	8	)	)	-RRB-
cord-334907-l4jjb93l	299	9	.	.	.
cord-334907-l4jjb93l	300	1	After	after	IN
cord-334907-l4jjb93l	300	2	the	the	DT
cord-334907-l4jjb93l	300	3	lectin	lectin	NN
cord-334907-l4jjb93l	300	4	incubation	incubation	NN
cord-334907-l4jjb93l	300	5	steps	step	NNS
cord-334907-l4jjb93l	300	6	,	,	,
cord-334907-l4jjb93l	300	7	cells	cell	NNS
cord-334907-l4jjb93l	300	8	were	be	VBD
cord-334907-l4jjb93l	300	9	washed	wash	VBN
cord-334907-l4jjb93l	300	10	three	three	CD
cord-334907-l4jjb93l	300	11	times	time	NNS
cord-334907-l4jjb93l	300	12	with	with	IN
cord-334907-l4jjb93l	300	13	PBS	PBS	NNP
cord-334907-l4jjb93l	300	14	.	.	.
cord-334907-l4jjb93l	301	1	Cells	cell	NNS
cord-334907-l4jjb93l	301	2	treated	treat	VBN
cord-334907-l4jjb93l	301	3	with	with	IN
cord-334907-l4jjb93l	301	4	single	single	JJ
cord-334907-l4jjb93l	301	5	lectins	lectin	NNS
cord-334907-l4jjb93l	301	6	were	be	VBD
cord-334907-l4jjb93l	301	7	incubated	incubate	VBN
cord-334907-l4jjb93l	301	8	with	with	IN
cord-334907-l4jjb93l	301	9	an	an	DT
cord-334907-l4jjb93l	301	10	anti	anti	JJ
cord-334907-l4jjb93l	301	11	-	-	JJ
cord-334907-l4jjb93l	301	12	FLAG	flag	JJ
cord-334907-l4jjb93l	301	13	M2	m2	JJ
cord-334907-l4jjb93l	301	14	antibody	antibody	NN
cord-334907-l4jjb93l	301	15	(	(	-LRB-
cord-334907-l4jjb93l	301	16	Sigma	Sigma	NNP
cord-334907-l4jjb93l	301	17	-	-	HYPH
cord-334907-l4jjb93l	301	18	Aldrich	Aldrich	NNP
cord-334907-l4jjb93l	301	19	,	,	,
cord-334907-l4jjb93l	301	20	St.	St.	NNP
cord-334907-l4jjb93l	301	21	Louis	Louis	NNP
cord-334907-l4jjb93l	301	22	,	,	,
cord-334907-l4jjb93l	301	23	Missouri	Missouri	NNP
cord-334907-l4jjb93l	301	24	,	,	,
cord-334907-l4jjb93l	301	25	USA	USA	NNP
cord-334907-l4jjb93l	301	26	)	)	-RRB-
cord-334907-l4jjb93l	301	27	at	at	IN
cord-334907-l4jjb93l	301	28	a	a	DT
cord-334907-l4jjb93l	301	29	1/100	1/100	CD
cord-334907-l4jjb93l	301	30	dilution	dilution	NN
cord-334907-l4jjb93l	301	31	in	in	IN
cord-334907-l4jjb93l	301	32	blocking	block	VBG
cord-334907-l4jjb93l	301	33	buffer	buffer	NN
cord-334907-l4jjb93l	301	34	.	.	.
cord-334907-l4jjb93l	302	1	Cells	cell	NNS
cord-334907-l4jjb93l	302	2	treated	treat	VBN
cord-334907-l4jjb93l	302	3	with	with	IN
cord-334907-l4jjb93l	302	4	rHE	rHE	NNP
cord-334907-l4jjb93l	302	5	and	and	CC
cord-334907-l4jjb93l	302	6	rF	rF	NNP
cord-334907-l4jjb93l	302	7	were	be	VBD
cord-334907-l4jjb93l	302	8	incubated	incubate	VBN
cord-334907-l4jjb93l	302	9	with	with	IN
cord-334907-l4jjb93l	302	10	an	an	DT
cord-334907-l4jjb93l	302	11	anti	anti	JJ
cord-334907-l4jjb93l	302	12	-	-	JJ
cord-334907-l4jjb93l	302	13	ISAV	isav	JJ
cord-334907-l4jjb93l	302	14	F	f	NN
cord-334907-l4jjb93l	302	15	(	(	-LRB-
cord-334907-l4jjb93l	302	16	8B2	8b2	CD
cord-334907-l4jjb93l	302	17	/	/	SYM
cord-334907-l4jjb93l	302	18	A4	a4	NN
cord-334907-l4jjb93l	302	19	)	)	-RRB-
cord-334907-l4jjb93l	303	1	(	(	-LRB-
cord-334907-l4jjb93l	303	2	Bioschile	Bioschile	NNP
cord-334907-l4jjb93l	303	3	,	,	,
cord-334907-l4jjb93l	303	4	Santiago	Santiago	NNP
cord-334907-l4jjb93l	303	5	,	,	,
cord-334907-l4jjb93l	303	6	Chile	Chile	NNP
cord-334907-l4jjb93l	303	7	)	)	-RRB-
cord-334907-l4jjb93l	303	8	at	at	IN
cord-334907-l4jjb93l	303	9	a	a	DT
cord-334907-l4jjb93l	303	10	1/250	1/250	CD
cord-334907-l4jjb93l	303	11	dilution	dilution	NN
cord-334907-l4jjb93l	303	12	.	.	.
cord-334907-l4jjb93l	304	1	After	after	IN
cord-334907-l4jjb93l	304	2	1	1	CD
cord-334907-l4jjb93l	304	3	h	h	NN
cord-334907-l4jjb93l	304	4	of	of	IN
cord-334907-l4jjb93l	304	5	incubation	incubation	NN
cord-334907-l4jjb93l	304	6	and	and	CC
cord-334907-l4jjb93l	304	7	three	three	CD
cord-334907-l4jjb93l	304	8	PBS	PBS	NNP
cord-334907-l4jjb93l	304	9	washes	wash	NNS
cord-334907-l4jjb93l	304	10	,	,	,
cord-334907-l4jjb93l	304	11	Alexa	Alexa	NNP
cord-334907-l4jjb93l	304	12	Fluor	Fluor	NNP
cord-334907-l4jjb93l	304	13	568	568	CD
cord-334907-l4jjb93l	304	14	conjugated	conjugate	VBN
cord-334907-l4jjb93l	304	15	goat	goat	NN
cord-334907-l4jjb93l	304	16	anti	anti	JJ
cord-334907-l4jjb93l	304	17	-	-	JJ
cord-334907-l4jjb93l	304	18	mouse	mouse	JJ
cord-334907-l4jjb93l	304	19	(	(	-LRB-
cord-334907-l4jjb93l	304	20	Thermo	Thermo	NNP
cord-334907-l4jjb93l	304	21	-	-	HYPH
cord-334907-l4jjb93l	304	22	Fisher	Fisher	NNP
cord-334907-l4jjb93l	304	23	,	,	,
cord-334907-l4jjb93l	304	24	Waltham	Waltham	NNP
cord-334907-l4jjb93l	304	25	,	,	,
cord-334907-l4jjb93l	304	26	MA	MA	NNP
cord-334907-l4jjb93l	304	27	,	,	,
cord-334907-l4jjb93l	304	28	USA	USA	NNP
cord-334907-l4jjb93l	304	29	)	)	-RRB-
cord-334907-l4jjb93l	304	30	was	be	VBD
cord-334907-l4jjb93l	304	31	added	add	VBN
cord-334907-l4jjb93l	304	32	to	to	IN
cord-334907-l4jjb93l	304	33	the	the	DT
cord-334907-l4jjb93l	304	34	cells	cell	NNS
cord-334907-l4jjb93l	304	35	at	at	IN
cord-334907-l4jjb93l	304	36	a	a	DT
cord-334907-l4jjb93l	304	37	1/200	1/200	CD
cord-334907-l4jjb93l	304	38	dilution	dilution	NN
cord-334907-l4jjb93l	304	39	in	in	IN
cord-334907-l4jjb93l	304	40	blocking	block	VBG
cord-334907-l4jjb93l	304	41	buffer	buffer	NN
cord-334907-l4jjb93l	304	42	.	.	.
cord-334907-l4jjb93l	305	1	Following	follow	VBG
cord-334907-l4jjb93l	305	2	a	a	DT
cord-334907-l4jjb93l	305	3	final	final	JJ
cord-334907-l4jjb93l	305	4	1	1	CD
cord-334907-l4jjb93l	305	5	h	h	NN
cord-334907-l4jjb93l	305	6	incubation	incubation	NN
cord-334907-l4jjb93l	305	7	,	,	,
cord-334907-l4jjb93l	305	8	cells	cell	NNS
cord-334907-l4jjb93l	305	9	were	be	VBD
cord-334907-l4jjb93l	305	10	washed	wash	VBN
cord-334907-l4jjb93l	305	11	three	three	CD
cord-334907-l4jjb93l	305	12	times	time	NNS
cord-334907-l4jjb93l	305	13	with	with	IN
cord-334907-l4jjb93l	305	14	PBS	PBS	NNP
cord-334907-l4jjb93l	305	15	,	,	,
cord-334907-l4jjb93l	305	16	and	and	CC
cord-334907-l4jjb93l	305	17	cell	cell	NN
cord-334907-l4jjb93l	305	18	nuclei	nucleus	NNS
cord-334907-l4jjb93l	305	19	were	be	VBD
cord-334907-l4jjb93l	305	20	stained	stain	VBN
cord-334907-l4jjb93l	305	21	with	with	IN
cord-334907-l4jjb93l	305	22	a	a	DT
cord-334907-l4jjb93l	305	23	solution	solution	NN
cord-334907-l4jjb93l	305	24	of	of	IN
cord-334907-l4jjb93l	305	25	TO	to	IN
cord-334907-l4jjb93l	305	26	-	-	HYPH
cord-334907-l4jjb93l	305	27	PRO-3	PRO-3	NNP
cord-334907-l4jjb93l	305	28	(	(	-LRB-
cord-334907-l4jjb93l	305	29	1	1	CD
cord-334907-l4jjb93l	305	30	µM	µm	CD
cord-334907-l4jjb93l	305	31	in	in	IN
cord-334907-l4jjb93l	305	32	PBS	PBS	NNP
cord-334907-l4jjb93l	305	33	)	)	-RRB-
cord-334907-l4jjb93l	306	1	(	(	-LRB-
cord-334907-l4jjb93l	306	2	Thermo	Thermo	NNP
cord-334907-l4jjb93l	306	3	-	-	HYPH
cord-334907-l4jjb93l	306	4	Fisher	Fisher	NNP
cord-334907-l4jjb93l	306	5	,	,	,
cord-334907-l4jjb93l	306	6	Waltham	Waltham	NNP
cord-334907-l4jjb93l	306	7	,	,	,
cord-334907-l4jjb93l	306	8	MA	MA	NNP
cord-334907-l4jjb93l	306	9	,	,	,
cord-334907-l4jjb93l	306	10	USA	USA	NNP
cord-334907-l4jjb93l	306	11	)	)	-RRB-
cord-334907-l4jjb93l	306	12	for	for	IN
cord-334907-l4jjb93l	306	13	1	1	CD
cord-334907-l4jjb93l	306	14	min	min	NN
cord-334907-l4jjb93l	306	15	.	.	.
cord-334907-l4jjb93l	307	1	After	after	IN
cord-334907-l4jjb93l	307	2	three	three	CD
cord-334907-l4jjb93l	307	3	final	final	JJ
cord-334907-l4jjb93l	307	4	washes	wash	NNS
cord-334907-l4jjb93l	307	5	with	with	IN
cord-334907-l4jjb93l	307	6	PBS	PBS	NNP
cord-334907-l4jjb93l	307	7	,	,	,
cord-334907-l4jjb93l	307	8	1	1	CD
cord-334907-l4jjb93l	307	9	mL	ml	NN
cord-334907-l4jjb93l	307	10	of	of	IN
cord-334907-l4jjb93l	307	11	the	the	DT
cord-334907-l4jjb93l	307	12	same	same	JJ
cord-334907-l4jjb93l	307	13	buffer	buffer	NN
cord-334907-l4jjb93l	307	14	was	be	VBD
cord-334907-l4jjb93l	307	15	added	add	VBN
cord-334907-l4jjb93l	307	16	,	,	,
cord-334907-l4jjb93l	307	17	and	and	CC
cord-334907-l4jjb93l	307	18	cells	cell	NNS
cord-334907-l4jjb93l	307	19	were	be	VBD
cord-334907-l4jjb93l	307	20	examined	examine	VBN
cord-334907-l4jjb93l	307	21	by	by	IN
cord-334907-l4jjb93l	307	22	confocal	confocal	JJ
cord-334907-l4jjb93l	307	23	microscopy	microscopy	NNS
cord-334907-l4jjb93l	307	24	using	use	VBG
cord-334907-l4jjb93l	307	25	the	the	DT
cord-334907-l4jjb93l	307	26	TCSSP5	TCSSP5	NNPS
cord-334907-l4jjb93l	307	27	II	II	NNP
cord-334907-l4jjb93l	307	28	confocal	confocal	JJ
cord-334907-l4jjb93l	307	29	microscope	microscope	NN
cord-334907-l4jjb93l	307	30	(	(	-LRB-
cord-334907-l4jjb93l	307	31	Leica	Leica	NNP
cord-334907-l4jjb93l	307	32	Microsystems	Microsystems	NNPS
cord-334907-l4jjb93l	307	33	Inc.	Inc.	NNP
cord-334907-l4jjb93l	307	34	,	,	,
cord-334907-l4jjb93l	307	35	Wetzlar	Wetzlar	NNP
cord-334907-l4jjb93l	307	36	,	,	,
cord-334907-l4jjb93l	307	37	Germany	Germany	NNP
cord-334907-l4jjb93l	307	38	)	)	-RRB-
cord-334907-l4jjb93l	307	39	.	.	.
cord-334907-l4jjb93l	308	1	ASK	ask	VB
cord-334907-l4jjb93l	308	2	cells	cell	NNS
cord-334907-l4jjb93l	308	3	at	at	IN
cord-334907-l4jjb93l	308	4	80	80	CD
cord-334907-l4jjb93l	308	5	%	%	NN
cord-334907-l4jjb93l	308	6	confluence	confluence	NN
cord-334907-l4jjb93l	308	7	,	,	,
cord-334907-l4jjb93l	308	8	growing	grow	VBG
cord-334907-l4jjb93l	308	9	on	on	IN
cord-334907-l4jjb93l	308	10	a	a	DT
cord-334907-l4jjb93l	308	11	six	six	CD
cord-334907-l4jjb93l	308	12	-	-	HYPH
cord-334907-l4jjb93l	308	13	well	well	JJ
cord-334907-l4jjb93l	308	14	plate	plate	NN
cord-334907-l4jjb93l	308	15	(	(	-LRB-
cord-334907-l4jjb93l	308	16	2.5	2.5	CD
cord-334907-l4jjb93l	308	17	×	×	NN
cord-334907-l4jjb93l	308	18	10	10	CD
cord-334907-l4jjb93l	308	19	5	5	CD
cord-334907-l4jjb93l	308	20	cells	cell	NNS
cord-334907-l4jjb93l	308	21	per	per	IN
cord-334907-l4jjb93l	308	22	well	well	RB
cord-334907-l4jjb93l	308	23	)	)	-RRB-
cord-334907-l4jjb93l	308	24	,	,	,
cord-334907-l4jjb93l	308	25	were	be	VBD
cord-334907-l4jjb93l	308	26	washed	wash	VBN
cord-334907-l4jjb93l	308	27	two	two	CD
cord-334907-l4jjb93l	308	28	times	time	NNS
cord-334907-l4jjb93l	308	29	with	with	IN
cord-334907-l4jjb93l	308	30	L-15	L-15	NNP
cord-334907-l4jjb93l	308	31	medium	medium	NN
cord-334907-l4jjb93l	308	32	.	.	.
cord-334907-l4jjb93l	309	1	Then	then	RB
cord-334907-l4jjb93l	309	2	,	,	,
cord-334907-l4jjb93l	309	3	each	each	DT
cord-334907-l4jjb93l	309	4	well	well	NN
cord-334907-l4jjb93l	309	5	was	be	VBD
cord-334907-l4jjb93l	309	6	incubated	incubate	VBN
cord-334907-l4jjb93l	309	7	with	with	IN
cord-334907-l4jjb93l	309	8	100	100	CD
cord-334907-l4jjb93l	309	9	ng	ng	NN
cord-334907-l4jjb93l	309	10	of	of	IN
cord-334907-l4jjb93l	309	11	Sf21-expressed	Sf21-expressed	NNP
cord-334907-l4jjb93l	309	12	rHE	rHE	NNP
cord-334907-l4jjb93l	309	13	,	,	,
cord-334907-l4jjb93l	309	14	rF	rF	NNP
cord-334907-l4jjb93l	309	15	,	,	,
cord-334907-l4jjb93l	309	16	or	or	CC
cord-334907-l4jjb93l	309	17	a	a	DT
cord-334907-l4jjb93l	309	18	mixture	mixture	NN
cord-334907-l4jjb93l	309	19	of	of	IN
cord-334907-l4jjb93l	309	20	both	both	DT
cord-334907-l4jjb93l	309	21	in	in	IN
cord-334907-l4jjb93l	309	22	L-15	L-15	NNP
cord-334907-l4jjb93l	309	23	medium	medium	NN
cord-334907-l4jjb93l	309	24	.	.	.
cord-334907-l4jjb93l	310	1	As	as	IN
cord-334907-l4jjb93l	310	2	control	control	NN
cord-334907-l4jjb93l	310	3	,	,	,
cord-334907-l4jjb93l	310	4	cells	cell	NNS
cord-334907-l4jjb93l	310	5	were	be	VBD
cord-334907-l4jjb93l	310	6	treated	treat	VBN
cord-334907-l4jjb93l	310	7	with	with	IN
cord-334907-l4jjb93l	310	8	100	100	CD
cord-334907-l4jjb93l	310	9	ng	ng	NN
cord-334907-l4jjb93l	310	10	of	of	IN
cord-334907-l4jjb93l	310	11	total	total	JJ
cord-334907-l4jjb93l	310	12	protein	protein	NN
cord-334907-l4jjb93l	310	13	from	from	IN
cord-334907-l4jjb93l	310	14	Sf21	sf21	NN
cord-334907-l4jjb93l	310	15	cells	cell	NNS
cord-334907-l4jjb93l	310	16	.	.	.
cord-334907-l4jjb93l	311	1	After	after	IN
cord-334907-l4jjb93l	311	2	a	a	DT
cord-334907-l4jjb93l	311	3	30	30	CD
cord-334907-l4jjb93l	311	4	min	min	NN
cord-334907-l4jjb93l	311	5	incubation	incubation	NN
cord-334907-l4jjb93l	311	6	,	,	,
cord-334907-l4jjb93l	311	7	cells	cell	NNS
cord-334907-l4jjb93l	311	8	were	be	VBD
cord-334907-l4jjb93l	311	9	washed	wash	VBN
cord-334907-l4jjb93l	311	10	six	six	CD
cord-334907-l4jjb93l	311	11	times	time	NNS
cord-334907-l4jjb93l	311	12	with	with	IN
cord-334907-l4jjb93l	311	13	L-15	L-15	NNP
cord-334907-l4jjb93l	311	14	medium	medium	NN
cord-334907-l4jjb93l	311	15	.	.	.
cord-334907-l4jjb93l	312	1	Then	then	RB
cord-334907-l4jjb93l	312	2	,	,	,
cord-334907-l4jjb93l	312	3	cells	cell	NNS
cord-334907-l4jjb93l	312	4	were	be	VBD
cord-334907-l4jjb93l	312	5	infected	infect	VBN
cord-334907-l4jjb93l	312	6	with	with	IN
cord-334907-l4jjb93l	312	7	ISAV	ISAV	NNP
cord-334907-l4jjb93l	312	8	HPR7b	HPR7b	NNP
cord-334907-l4jjb93l	312	9	at	at	IN
cord-334907-l4jjb93l	312	10	an	an	DT
cord-334907-l4jjb93l	312	11	MOI	MOI	NNP
cord-334907-l4jjb93l	312	12	of	of	IN
cord-334907-l4jjb93l	312	13	0.01	0.01	CD
cord-334907-l4jjb93l	312	14	,	,	,
cord-334907-l4jjb93l	312	15	as	as	IN
cord-334907-l4jjb93l	312	16	described	describe	VBN
cord-334907-l4jjb93l	312	17	above	above	RB
cord-334907-l4jjb93l	312	18	.	.	.
cord-334907-l4jjb93l	313	1	Total	Total	NNP
cord-334907-l4jjb93l	313	2	RNA	RNA	NNP
cord-334907-l4jjb93l	313	3	was	be	VBD
cord-334907-l4jjb93l	313	4	extracted	extract	VBN
cord-334907-l4jjb93l	313	5	from	from	IN
cord-334907-l4jjb93l	313	6	the	the	DT
cord-334907-l4jjb93l	313	7	cells	cell	NNS
cord-334907-l4jjb93l	313	8	48	48	CD
cord-334907-l4jjb93l	313	9	h	h	NN
cord-334907-l4jjb93l	313	10	post	post	NN
cord-334907-l4jjb93l	313	11	-	-	NN
cord-334907-l4jjb93l	313	12	infection	infection	JJ
cord-334907-l4jjb93l	313	13	(	(	-LRB-
cord-334907-l4jjb93l	313	14	h.p.i	h.p.i	NNP
cord-334907-l4jjb93l	313	15	.	.	.
cord-334907-l4jjb93l	313	16	)	)	-RRB-
cord-334907-l4jjb93l	313	17	using	use	VBG
cord-334907-l4jjb93l	313	18	the	the	DT
cord-334907-l4jjb93l	313	19	TRIzol	TRIzol	NNP
cord-334907-l4jjb93l	313	20	reagent	reagent	NN
cord-334907-l4jjb93l	313	21	(	(	-LRB-
cord-334907-l4jjb93l	313	22	Life	Life	NNP
cord-334907-l4jjb93l	313	23	Technologies	Technologies	NNPS
cord-334907-l4jjb93l	313	24	,	,	,
cord-334907-l4jjb93l	313	25	Carlsbad	Carlsbad	NNP
cord-334907-l4jjb93l	313	26	,	,	,
cord-334907-l4jjb93l	313	27	California	California	NNP
cord-334907-l4jjb93l	313	28	,	,	,
cord-334907-l4jjb93l	313	29	USA	USA	NNP
cord-334907-l4jjb93l	313	30	)	)	-RRB-
cord-334907-l4jjb93l	313	31	and	and	CC
cord-334907-l4jjb93l	313	32	suspended	suspend	VBN
cord-334907-l4jjb93l	313	33	in	in	IN
cord-334907-l4jjb93l	313	34	nuclease	nuclease	NN
cord-334907-l4jjb93l	313	35	-	-	HYPH
cord-334907-l4jjb93l	313	36	free	free	JJ
cord-334907-l4jjb93l	313	37	water	water	NN
cord-334907-l4jjb93l	313	38	.	.	.
cord-334907-l4jjb93l	314	1	A	a	DT
cord-334907-l4jjb93l	314	2	2	2	CD
cord-334907-l4jjb93l	314	3	µL	µl	XX
cord-334907-l4jjb93l	315	1	RNA	RNA	NNP
cord-334907-l4jjb93l	315	2	sample	sample	NN
cord-334907-l4jjb93l	315	3	was	be	VBD
cord-334907-l4jjb93l	315	4	used	use	VBN
cord-334907-l4jjb93l	315	5	as	as	IN
cord-334907-l4jjb93l	315	6	template	template	NN
cord-334907-l4jjb93l	315	7	for	for	IN
cord-334907-l4jjb93l	315	8	qRT	qrt	ADD
cord-334907-l4jjb93l	315	9	-	-	HYPH
cord-334907-l4jjb93l	315	10	PCR	PCR	NNP
cord-334907-l4jjb93l	315	11	reactions	reaction	NNS
cord-334907-l4jjb93l	315	12	using	use	VBG
cord-334907-l4jjb93l	315	13	the	the	DT
cord-334907-l4jjb93l	315	14	Stratagene	Stratagene	NNP
cord-334907-l4jjb93l	315	15	qRT	qRT	NNP
cord-334907-l4jjb93l	315	16	-	-	HYPH
cord-334907-l4jjb93l	315	17	PCR	PCR	NNP
cord-334907-l4jjb93l	315	18	III	III	NNP
cord-334907-l4jjb93l	315	19	Master	Master	NNP
cord-334907-l4jjb93l	315	20	Mix	Mix	NNP
cord-334907-l4jjb93l	315	21	according	accord	VBG
cord-334907-l4jjb93l	315	22	to	to	IN
cord-334907-l4jjb93l	315	23	the	the	DT
cord-334907-l4jjb93l	315	24	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	315	25	's	's	POS
cord-334907-l4jjb93l	315	26	instructions	instruction	NNS
cord-334907-l4jjb93l	315	27	.	.	.
cord-334907-l4jjb93l	316	1	Specific	specific	JJ
cord-334907-l4jjb93l	316	2	primers	primer	NNS
cord-334907-l4jjb93l	316	3	were	be	VBD
cord-334907-l4jjb93l	316	4	used	use	VBN
cord-334907-l4jjb93l	316	5	to	to	TO
cord-334907-l4jjb93l	316	6	analyze	analyze	VB
cord-334907-l4jjb93l	316	7	the	the	DT
cord-334907-l4jjb93l	316	8	expression	expression	NN
cord-334907-l4jjb93l	316	9	of	of	IN
cord-334907-l4jjb93l	316	10	viral	viral	JJ
cord-334907-l4jjb93l	316	11	genes	gene	NNS
cord-334907-l4jjb93l	316	12	(	(	-LRB-
cord-334907-l4jjb93l	316	13	viral	viral	JJ
cord-334907-l4jjb93l	316	14	segment	segment	NN
cord-334907-l4jjb93l	316	15	8)	8)	NNP
cord-334907-l4jjb93l	317	1	[	[	-LRB-
cord-334907-l4jjb93l	317	2	54	54	CD
cord-334907-l4jjb93l	317	3	]	]	-RRB-
cord-334907-l4jjb93l	317	4	and	and	CC
cord-334907-l4jjb93l	317	5	that	that	DT
cord-334907-l4jjb93l	317	6	of	of	IN
cord-334907-l4jjb93l	317	7	a	a	DT
cord-334907-l4jjb93l	317	8	cellular	cellular	JJ
cord-334907-l4jjb93l	317	9	housekeeping	housekeeping	NN
cord-334907-l4jjb93l	317	10	gene	gene	NN
cord-334907-l4jjb93l	317	11	(	(	-LRB-
cord-334907-l4jjb93l	317	12	elongation	elongation	NN
cord-334907-l4jjb93l	317	13	factor	factor	NN
cord-334907-l4jjb93l	317	14	1α	1α	CD
cord-334907-l4jjb93l	317	15	)	)	-RRB-
cord-334907-l4jjb93l	317	16	used	use	VBN
cord-334907-l4jjb93l	317	17	for	for	IN
cord-334907-l4jjb93l	317	18	normalization	normalization	NN
cord-334907-l4jjb93l	317	19	[	[	-LRB-
cord-334907-l4jjb93l	317	20	55	55	CD
cord-334907-l4jjb93l	317	21	]	]	-RRB-
cord-334907-l4jjb93l	317	22	.	.	.
cord-334907-l4jjb93l	318	1	The	the	DT
cord-334907-l4jjb93l	318	2	fold	fold	JJ
cord-334907-l4jjb93l	318	3	-	-	HYPH
cord-334907-l4jjb93l	318	4	change	change	NN
cord-334907-l4jjb93l	318	5	of	of	IN
cord-334907-l4jjb93l	318	6	viral	viral	JJ
cord-334907-l4jjb93l	318	7	gene	gene	NN
cord-334907-l4jjb93l	318	8	expression	expression	NN
cord-334907-l4jjb93l	318	9	relative	relative	JJ
cord-334907-l4jjb93l	318	10	to	to	IN
cord-334907-l4jjb93l	318	11	the	the	DT
cord-334907-l4jjb93l	318	12	control	control	NN
cord-334907-l4jjb93l	318	13	was	be	VBD
cord-334907-l4jjb93l	318	14	assessed	assess	VBN
cord-334907-l4jjb93l	318	15	using	use	VBG
cord-334907-l4jjb93l	318	16	the	the	DT
cord-334907-l4jjb93l	318	17	2	2	CD
cord-334907-l4jjb93l	318	18	-∆∆CT	-∆∆ct	NN
cord-334907-l4jjb93l	318	19	method	method	NN
cord-334907-l4jjb93l	318	20	,	,	,
cord-334907-l4jjb93l	318	21	as	as	IN
cord-334907-l4jjb93l	318	22	previously	previously	RB
cord-334907-l4jjb93l	318	23	described	describe	VBN
cord-334907-l4jjb93l	318	24	[	[	-LRB-
cord-334907-l4jjb93l	318	25	56	56	CD
cord-334907-l4jjb93l	318	26	]	]	-RRB-
cord-334907-l4jjb93l	318	27	(	(	-LRB-
cord-334907-l4jjb93l	318	28	Table	table	NN
cord-334907-l4jjb93l	318	29	2	2	CD
cord-334907-l4jjb93l	318	30	)	)	-RRB-
cord-334907-l4jjb93l	318	31	.	.	.
cord-334907-l4jjb93l	319	1	Table	table	NN
cord-334907-l4jjb93l	319	2	2	2	CD
cord-334907-l4jjb93l	319	3	.	.	.
cord-334907-l4jjb93l	320	1	Primers	primer	NNS
cord-334907-l4jjb93l	320	2	used	use	VBD
cord-334907-l4jjb93l	320	3	to	to	TO
cord-334907-l4jjb93l	320	4	amplify	amplify	VB
cord-334907-l4jjb93l	320	5	the	the	DT
cord-334907-l4jjb93l	320	6	viral	viral	JJ
cord-334907-l4jjb93l	320	7	ORF	ORF	NNP
cord-334907-l4jjb93l	320	8	corresponding	correspond	VBG
cord-334907-l4jjb93l	320	9	to	to	IN
cord-334907-l4jjb93l	320	10	HE	HE	NNP
cord-334907-l4jjb93l	320	11	and	and	CC
cord-334907-l4jjb93l	320	12	F	F	NNP
cord-334907-l4jjb93l	320	13	proteins	protein	NNS
cord-334907-l4jjb93l	320	14	,	,	,
cord-334907-l4jjb93l	320	15	to	to	TO
cord-334907-l4jjb93l	320	16	add	add	VB
cord-334907-l4jjb93l	320	17	restriction	restriction	NN
cord-334907-l4jjb93l	320	18	sites	site	NNS
cord-334907-l4jjb93l	320	19	for	for	IN
cord-334907-l4jjb93l	320	20	cloning	clone	VBG
cord-334907-l4jjb93l	320	21	in	in	IN
cord-334907-l4jjb93l	320	22	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	320	23	-	-	HYPH
cord-334907-l4jjb93l	320	24	CMV14	CMV14	NNP
cord-334907-l4jjb93l	320	25	,	,	,
cord-334907-l4jjb93l	320	26	to	to	TO
cord-334907-l4jjb93l	320	27	mutate	mutate	VB
cord-334907-l4jjb93l	320	28	specific	specific	JJ
cord-334907-l4jjb93l	320	29	residues	residue	NNS
cord-334907-l4jjb93l	320	30	in	in	IN
cord-334907-l4jjb93l	320	31	both	both	DT
cord-334907-l4jjb93l	320	32	,	,	,
cord-334907-l4jjb93l	320	33	and	and	CC
cord-334907-l4jjb93l	320	34	to	to	TO
cord-334907-l4jjb93l	320	35	evaluate	evaluate	VB
cord-334907-l4jjb93l	320	36	the	the	DT
cord-334907-l4jjb93l	320	37	expression	expression	NN
cord-334907-l4jjb93l	320	38	of	of	IN
cord-334907-l4jjb93l	320	39	viral	viral	JJ
cord-334907-l4jjb93l	320	40	and	and	CC
cord-334907-l4jjb93l	320	41	cellular	cellular	JJ
cord-334907-l4jjb93l	320	42	genes	gene	NNS
cord-334907-l4jjb93l	320	43	.	.	.
cord-334907-l4jjb93l	321	1	HE	he	PRP
cord-334907-l4jjb93l	321	2	was	be	VBD
cord-334907-l4jjb93l	321	3	cloned	clone	VBN
cord-334907-l4jjb93l	321	4	between	between	IN
cord-334907-l4jjb93l	321	5	the	the	DT
cord-334907-l4jjb93l	321	6	Not	not	RB
cord-334907-l4jjb93l	321	7	I	-PRON-	PRP
cord-334907-l4jjb93l	321	8	and	and	CC
cord-334907-l4jjb93l	321	9	Kpn	Kpn	NNP
cord-334907-l4jjb93l	321	10	I	-PRON-	PRP
cord-334907-l4jjb93l	321	11	sites	site	NNS
cord-334907-l4jjb93l	321	12	on	on	IN
cord-334907-l4jjb93l	321	13	the	the	DT
cord-334907-l4jjb93l	321	14	expression	expression	NN
cord-334907-l4jjb93l	321	15	vector	vector	NN
cord-334907-l4jjb93l	321	16	.	.	.
cord-334907-l4jjb93l	322	1	For	for	IN
cord-334907-l4jjb93l	322	2	the	the	DT
cord-334907-l4jjb93l	322	3	HE	HE	NNP
cord-334907-l4jjb93l	322	4	-	-	HYPH
cord-334907-l4jjb93l	322	5	eGFP	eGFP	NNP
cord-334907-l4jjb93l	322	6	fusion	fusion	NN
cord-334907-l4jjb93l	322	7	,	,	,
cord-334907-l4jjb93l	322	8	an	an	DT
cord-334907-l4jjb93l	322	9	Xba	Xba	NNP
cord-334907-l4jjb93l	322	10	I	-PRON-	PRP
cord-334907-l4jjb93l	322	11	site	site	NN
cord-334907-l4jjb93l	322	12	was	be	VBD
cord-334907-l4jjb93l	322	13	added	add	VBN
cord-334907-l4jjb93l	322	14	to	to	IN
cord-334907-l4jjb93l	322	15	the	the	DT
cord-334907-l4jjb93l	322	16	3	3	CD
cord-334907-l4jjb93l	322	17	and	and	CC
cord-334907-l4jjb93l	322	18	5	5	CD
cord-334907-l4jjb93l	322	19	sites	site	NNS
cord-334907-l4jjb93l	322	20	of	of	IN
cord-334907-l4jjb93l	322	21	HE	HE	NNP
cord-334907-l4jjb93l	322	22	and	and	CC
cord-334907-l4jjb93l	322	23	eGFP	eGFP	NNP
cord-334907-l4jjb93l	322	24	,	,	,
cord-334907-l4jjb93l	322	25	respectively	respectively	RB
cord-334907-l4jjb93l	322	26	,	,	,
cord-334907-l4jjb93l	322	27	due	due	IN
cord-334907-l4jjb93l	322	28	to	to	IN
cord-334907-l4jjb93l	322	29	a	a	DT
cord-334907-l4jjb93l	322	30	Kpn	Kpn	NNP
cord-334907-l4jjb93l	322	31	I	-PRON-	PRP
cord-334907-l4jjb93l	322	32	site	site	NN
cord-334907-l4jjb93l	322	33	present	present	JJ
cord-334907-l4jjb93l	322	34	in	in	IN
cord-334907-l4jjb93l	322	35	the	the	DT
cord-334907-l4jjb93l	322	36	fluorescent	fluorescent	JJ
cord-334907-l4jjb93l	322	37	protein	protein	NN
cord-334907-l4jjb93l	322	38	gene	gene	NN
cord-334907-l4jjb93l	322	39	.	.	.
cord-334907-l4jjb93l	323	1	HE	HE	NNP
cord-334907-l4jjb93l	323	2	and	and	CC
cord-334907-l4jjb93l	323	3	F	F	NNP
cord-334907-l4jjb93l	323	4	fusion	fusion	NN
cord-334907-l4jjb93l	323	5	proteins	protein	NNS
cord-334907-l4jjb93l	323	6	were	be	VBD
cord-334907-l4jjb93l	323	7	cloned	clone	VBN
cord-334907-l4jjb93l	323	8	between	between	IN
cord-334907-l4jjb93l	323	9	the	the	DT
cord-334907-l4jjb93l	323	10	Not	not	RB
cord-334907-l4jjb93l	323	11	I	I	NNP
cord-334907-l4jjb93l	323	12	/	/	SYM
cord-334907-l4jjb93l	323	13	Bam	Bam	NNP
cord-334907-l4jjb93l	323	14	HI	HI	NNP
cord-334907-l4jjb93l	323	15	and	and	CC
cord-334907-l4jjb93l	323	16	Eco	Eco	NNP
cord-334907-l4jjb93l	323	17	RI	RI	NNP
cord-334907-l4jjb93l	323	18	/	/	SYM
cord-334907-l4jjb93l	323	19	Bam	Bam	NNP
cord-334907-l4jjb93l	323	20	HI	HI	NNP
cord-334907-l4jjb93l	323	21	sites	site	NNS
cord-334907-l4jjb93l	323	22	of	of	IN
cord-334907-l4jjb93l	323	23	the	the	DT
cord-334907-l4jjb93l	323	24	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	323	25	-	-	HYPH
cord-334907-l4jjb93l	323	26	CMV14	CMV14	NNP
cord-334907-l4jjb93l	323	27	vector	vector	NN
cord-334907-l4jjb93l	323	28	.	.	.
cord-334907-l4jjb93l	323	29	 	 	_SP
cord-334907-l4jjb93l	324	1	A	a	DT
cord-334907-l4jjb93l	324	2	reference	reference	NN
cord-334907-l4jjb93l	324	3	sequence	sequence	NN
cord-334907-l4jjb93l	324	4	(	(	-LRB-
cord-334907-l4jjb93l	324	5	AAX46273.1	aax46273.1	RB
cord-334907-l4jjb93l	324	6	)	)	-RRB-
cord-334907-l4jjb93l	324	7	for	for	IN
cord-334907-l4jjb93l	324	8	the	the	DT
cord-334907-l4jjb93l	324	9	ISAV	ISAV	NNP
cord-334907-l4jjb93l	324	10	fusion	fusion	NN
cord-334907-l4jjb93l	324	11	protein	protein	NN
cord-334907-l4jjb93l	324	12	was	be	VBD
cord-334907-l4jjb93l	324	13	retrieved	retrieve	VBN
cord-334907-l4jjb93l	324	14	from	from	IN
cord-334907-l4jjb93l	324	15	NCBI	NCBI	NNP
cord-334907-l4jjb93l	324	16	protein	protein	NN
cord-334907-l4jjb93l	324	17	sequence	sequence	NN
cord-334907-l4jjb93l	324	18	database	database	NN
cord-334907-l4jjb93l	324	19	[	[	-LRB-
cord-334907-l4jjb93l	324	20	15	15	CD
cord-334907-l4jjb93l	324	21	]	]	-RRB-
cord-334907-l4jjb93l	324	22	and	and	CC
cord-334907-l4jjb93l	324	23	was	be	VBD
cord-334907-l4jjb93l	324	24	analyzed	analyze	VBN
cord-334907-l4jjb93l	324	25	with	with	IN
cord-334907-l4jjb93l	324	26	the	the	DT
cord-334907-l4jjb93l	324	27	PSIPRED	PSIPRED	NNP
cord-334907-l4jjb93l	324	28	method	method	NN
cord-334907-l4jjb93l	324	29	v3.3	v3.3	VBZ
cord-334907-l4jjb93l	324	30	to	to	TO
cord-334907-l4jjb93l	324	31	predict	predict	VB
cord-334907-l4jjb93l	324	32	secondary	secondary	JJ
cord-334907-l4jjb93l	324	33	structure	structure	NN
cord-334907-l4jjb93l	324	34	[	[	-LRB-
cord-334907-l4jjb93l	324	35	57	57	CD
cord-334907-l4jjb93l	324	36	]	]	-RRB-
cord-334907-l4jjb93l	324	37	.	.	.
cord-334907-l4jjb93l	325	1	Comparison	comparison	NN
cord-334907-l4jjb93l	325	2	with	with	IN
cord-334907-l4jjb93l	325	3	the	the	DT
cord-334907-l4jjb93l	325	4	sequences	sequence	NNS
cord-334907-l4jjb93l	325	5	and	and	CC
cord-334907-l4jjb93l	325	6	experimental	experimental	JJ
cord-334907-l4jjb93l	325	7	secondary	secondary	JJ
cord-334907-l4jjb93l	325	8	structures	structure	NNS
cord-334907-l4jjb93l	325	9	for	for	IN
cord-334907-l4jjb93l	325	10	hemagglutinins	hemagglutinin	NNS
cord-334907-l4jjb93l	325	11	from	from	IN
cord-334907-l4jjb93l	325	12	porcine	porcine	JJ
cord-334907-l4jjb93l	325	13	torovirus	torovirus	NNP
cord-334907-l4jjb93l	325	14	(	(	-LRB-
cord-334907-l4jjb93l	325	15	PToV	PToV	NNP
cord-334907-l4jjb93l	325	16	)	)	-RRB-
cord-334907-l4jjb93l	325	17	(	(	-LRB-
cord-334907-l4jjb93l	325	18	3i1k	3i1k	CD
cord-334907-l4jjb93l	325	19	)	)	-RRB-
cord-334907-l4jjb93l	325	20	,	,	,
cord-334907-l4jjb93l	325	21	bovine	bovine	JJ
cord-334907-l4jjb93l	325	22	coronavirus	coronavirus	NN
cord-334907-l4jjb93l	325	23	(	(	-LRB-
cord-334907-l4jjb93l	325	24	3cl5	3cl5	NNP
cord-334907-l4jjb93l	325	25	)	)	-RRB-
cord-334907-l4jjb93l	325	26	and	and	CC
cord-334907-l4jjb93l	325	27	influenza	influenza	NN
cord-334907-l4jjb93l	325	28	C	c	NN
cord-334907-l4jjb93l	325	29	virus	virus	NN
cord-334907-l4jjb93l	325	30	(	(	-LRB-
cord-334907-l4jjb93l	325	31	1flc	1flc	CD
cord-334907-l4jjb93l	325	32	)	)	-RRB-
cord-334907-l4jjb93l	325	33	was	be	VBD
cord-334907-l4jjb93l	325	34	performed	perform	VBN
cord-334907-l4jjb93l	325	35	,	,	,
cord-334907-l4jjb93l	325	36	in	in	IN
cord-334907-l4jjb93l	325	37	order	order	NN
cord-334907-l4jjb93l	325	38	to	to	TO
cord-334907-l4jjb93l	325	39	define	define	VB
cord-334907-l4jjb93l	325	40	a	a	DT
cord-334907-l4jjb93l	325	41	putative	putative	JJ
cord-334907-l4jjb93l	325	42	ligand	ligand	NN
cord-334907-l4jjb93l	325	43	interacting	interact	VBG
cord-334907-l4jjb93l	325	44	domain	domain	NN
cord-334907-l4jjb93l	325	45	for	for	IN
cord-334907-l4jjb93l	325	46	ISAV	ISAV	NNP
cord-334907-l4jjb93l	325	47	F	F	NNP
cord-334907-l4jjb93l	325	48	[	[	-LRB-
cord-334907-l4jjb93l	325	49	32	32	CD
cord-334907-l4jjb93l	325	50	,	,	,
cord-334907-l4jjb93l	325	51	42	42	CD
cord-334907-l4jjb93l	325	52	,	,	,
cord-334907-l4jjb93l	325	53	45	45	CD
cord-334907-l4jjb93l	325	54	]	]	-RRB-
cord-334907-l4jjb93l	325	55	.	.	.
cord-334907-l4jjb93l	326	1	A	a	DT
cord-334907-l4jjb93l	326	2	3D	3d	JJ
cord-334907-l4jjb93l	326	3	model	model	NN
cord-334907-l4jjb93l	326	4	of	of	IN
cord-334907-l4jjb93l	326	5	a	a	DT
cord-334907-l4jjb93l	326	6	partial	partial	JJ
cord-334907-l4jjb93l	326	7	F	F	NNP
cord-334907-l4jjb93l	326	8	1	1	CD
cord-334907-l4jjb93l	326	9	domain	domain	NN
cord-334907-l4jjb93l	326	10	was	be	VBD
cord-334907-l4jjb93l	326	11	obtained	obtain	VBN
cord-334907-l4jjb93l	326	12	based	base	VBN
cord-334907-l4jjb93l	326	13	on	on	IN
cord-334907-l4jjb93l	326	14	manual	manual	JJ
cord-334907-l4jjb93l	326	15	alignment	alignment	NN
cord-334907-l4jjb93l	326	16	with	with	IN
cord-334907-l4jjb93l	326	17	the	the	DT
cord-334907-l4jjb93l	326	18	PToV	PToV	NNP
cord-334907-l4jjb93l	326	19	HE	HE	NNP
cord-334907-l4jjb93l	326	20	structure	structure	NN
cord-334907-l4jjb93l	326	21	sequence	sequence	NN
cord-334907-l4jjb93l	326	22	.	.	.
cord-334907-l4jjb93l	327	1	Comparative	comparative	JJ
cord-334907-l4jjb93l	327	2	modeling	modeling	NN
cord-334907-l4jjb93l	327	3	was	be	VBD
cord-334907-l4jjb93l	327	4	performed	perform	VBN
cord-334907-l4jjb93l	327	5	using	use	VBG
cord-334907-l4jjb93l	327	6	the	the	DT
cord-334907-l4jjb93l	327	7	MODELLER	MODELLER	NNP
cord-334907-l4jjb93l	327	8	interface	interface	NN
cord-334907-l4jjb93l	327	9	in	in	IN
cord-334907-l4jjb93l	327	10	UCSF	UCSF	NNP
cord-334907-l4jjb93l	327	11	Chimera	Chimera	NNP
cord-334907-l4jjb93l	327	12	[	[	-LRB-
cord-334907-l4jjb93l	327	13	34	34	CD
cord-334907-l4jjb93l	327	14	,	,	,
cord-334907-l4jjb93l	327	15	58	58	CD
cord-334907-l4jjb93l	327	16	]	]	-RRB-
cord-334907-l4jjb93l	327	17	,	,	,
cord-334907-l4jjb93l	327	18	using	use	VBG
cord-334907-l4jjb93l	327	19	the	the	DT
cord-334907-l4jjb93l	327	20	PToV	PToV	NNP
cord-334907-l4jjb93l	327	21	HE	HE	NNP
cord-334907-l4jjb93l	327	22	structure	structure	NN
cord-334907-l4jjb93l	327	23	as	as	IN
cord-334907-l4jjb93l	327	24	template	template	NN
cord-334907-l4jjb93l	327	25	.	.	.
cord-334907-l4jjb93l	328	1	Sequence	sequence	NN
cord-334907-l4jjb93l	328	2	alignment	alignment	NN
cord-334907-l4jjb93l	328	3	was	be	VBD
cord-334907-l4jjb93l	328	4	performed	perform	VBN
cord-334907-l4jjb93l	328	5	using	use	VBG
cord-334907-l4jjb93l	328	6	Jalview	Jalview	NNP
cord-334907-l4jjb93l	328	7	[	[	-LRB-
cord-334907-l4jjb93l	328	8	59	59	CD
cord-334907-l4jjb93l	328	9	]	]	-RRB-
cord-334907-l4jjb93l	328	10	.	.	.
cord-334907-l4jjb93l	329	1	Alignment	alignment	JJ
cord-334907-l4jjb93l	329	2	and	and	CC
cord-334907-l4jjb93l	329	3	structural	structural	JJ
cord-334907-l4jjb93l	329	4	representations	representation	NNS
cord-334907-l4jjb93l	329	5	were	be	VBD
cord-334907-l4jjb93l	329	6	obtained	obtain	VBN
cord-334907-l4jjb93l	329	7	using	use	VBG
cord-334907-l4jjb93l	329	8	CLC	CLC	NNP
cord-334907-l4jjb93l	329	9	Genomic	Genomic	NNP
cord-334907-l4jjb93l	329	10	Workbench	Workbench	NNP
cord-334907-l4jjb93l	329	11	(	(	-LRB-
cord-334907-l4jjb93l	329	12	Qiagen	Qiagen	NNP
cord-334907-l4jjb93l	329	13	,	,	,
cord-334907-l4jjb93l	329	14	Hilden	Hilden	NNP
cord-334907-l4jjb93l	329	15	,	,	,
cord-334907-l4jjb93l	329	16	Germany	Germany	NNP
cord-334907-l4jjb93l	329	17	)	)	-RRB-
cord-334907-l4jjb93l	329	18	.	.	.
cord-334907-l4jjb93l	330	1	Total	Total	NNP
cord-334907-l4jjb93l	330	2	RNA	RNA	NNP
cord-334907-l4jjb93l	330	3	was	be	VBD
cord-334907-l4jjb93l	330	4	extracted	extract	VBN
cord-334907-l4jjb93l	330	5	from	from	IN
cord-334907-l4jjb93l	330	6	ASK	ask	NN
cord-334907-l4jjb93l	330	7	cells	cell	NNS
cord-334907-l4jjb93l	330	8	infected	infect	VBN
cord-334907-l4jjb93l	330	9	with	with	IN
cord-334907-l4jjb93l	330	10	ISAV	ISAV	NNP
cord-334907-l4jjb93l	330	11	HPR3	HPR3	NNP
cord-334907-l4jjb93l	330	12	,	,	,
cord-334907-l4jjb93l	330	13	as	as	IN
cord-334907-l4jjb93l	330	14	described	describe	VBN
cord-334907-l4jjb93l	330	15	before	before	RB
cord-334907-l4jjb93l	330	16	,	,	,
cord-334907-l4jjb93l	330	17	using	use	VBG
cord-334907-l4jjb93l	330	18	the	the	DT
cord-334907-l4jjb93l	330	19	TRIzol	TRIzol	NNP
cord-334907-l4jjb93l	330	20	reagent	reagent	NN
cord-334907-l4jjb93l	330	21	(	(	-LRB-
cord-334907-l4jjb93l	330	22	Life	Life	NNP
cord-334907-l4jjb93l	330	23	Technologies	Technologies	NNPS
cord-334907-l4jjb93l	330	24	,	,	,
cord-334907-l4jjb93l	330	25	Carlsbad	Carlsbad	NNP
cord-334907-l4jjb93l	330	26	,	,	,
cord-334907-l4jjb93l	330	27	California	California	NNP
cord-334907-l4jjb93l	330	28	,	,	,
cord-334907-l4jjb93l	330	29	USA	USA	NNP
cord-334907-l4jjb93l	330	30	)	)	-RRB-
cord-334907-l4jjb93l	330	31	according	accord	VBG
cord-334907-l4jjb93l	330	32	to	to	IN
cord-334907-l4jjb93l	330	33	the	the	DT
cord-334907-l4jjb93l	330	34	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	330	35	's	's	POS
cord-334907-l4jjb93l	330	36	instructions	instruction	NNS
cord-334907-l4jjb93l	330	37	.	.	.
cord-334907-l4jjb93l	331	1	A	a	DT
cord-334907-l4jjb93l	331	2	10	10	CD
cord-334907-l4jjb93l	331	3	mg	mg	NN
cord-334907-l4jjb93l	331	4	kidney	kidney	NN
cord-334907-l4jjb93l	331	5	sample	sample	NN
cord-334907-l4jjb93l	331	6	from	from	IN
cord-334907-l4jjb93l	331	7	an	an	DT
cord-334907-l4jjb93l	331	8	ISAV	ISAV	NNP
cord-334907-l4jjb93l	331	9	HPR0	HPR0	NNP
cord-334907-l4jjb93l	331	10	infected	infected	JJ
cord-334907-l4jjb93l	331	11	salmon	salmon	NN
cord-334907-l4jjb93l	331	12	was	be	VBD
cord-334907-l4jjb93l	331	13	obtained	obtain	VBN
cord-334907-l4jjb93l	331	14	from	from	IN
cord-334907-l4jjb93l	331	15	the	the	DT
cord-334907-l4jjb93l	331	16	Laboratorio	Laboratorio	NNP
cord-334907-l4jjb93l	331	17	de	de	IN
cord-334907-l4jjb93l	331	18	Patógenos	Patógenos	NNP
cord-334907-l4jjb93l	331	19	Acuícolas	Acuícolas	NNP
cord-334907-l4jjb93l	331	20	,	,	,
cord-334907-l4jjb93l	331	21	and	and	CC
cord-334907-l4jjb93l	331	22	total	total	JJ
cord-334907-l4jjb93l	331	23	RNA	RNA	NNP
cord-334907-l4jjb93l	331	24	was	be	VBD
cord-334907-l4jjb93l	331	25	extracted	extract	VBN
cord-334907-l4jjb93l	331	26	using	use	VBG
cord-334907-l4jjb93l	331	27	the	the	DT
cord-334907-l4jjb93l	331	28	TRIzol	TRIzol	NNP
cord-334907-l4jjb93l	331	29	Reagent	Reagent	NNP
cord-334907-l4jjb93l	331	30	,	,	,
cord-334907-l4jjb93l	331	31	as	as	IN
cord-334907-l4jjb93l	331	32	described	describe	VBN
cord-334907-l4jjb93l	331	33	above	above	RB
cord-334907-l4jjb93l	331	34	.	.	.
cord-334907-l4jjb93l	332	1	cDNA	cDNA	NNP
cord-334907-l4jjb93l	332	2	was	be	VBD
cord-334907-l4jjb93l	332	3	synthesized	synthesize	VBN
cord-334907-l4jjb93l	332	4	from	from	IN
cord-334907-l4jjb93l	332	5	5	5	CD
cord-334907-l4jjb93l	332	6	µg	µg	CD
cord-334907-l4jjb93l	332	7	of	of	IN
cord-334907-l4jjb93l	332	8	total	total	JJ
cord-334907-l4jjb93l	332	9	RNA	RNA	NNP
cord-334907-l4jjb93l	332	10	with	with	IN
cord-334907-l4jjb93l	332	11	M	M	NNP
cord-334907-l4jjb93l	332	12	-	-	HYPH
cord-334907-l4jjb93l	332	13	MLV	MLV	NNP
cord-334907-l4jjb93l	332	14	Reverse	Reverse	NNP
cord-334907-l4jjb93l	332	15	Transcriptase	Transcriptase	NNP
cord-334907-l4jjb93l	332	16	(	(	-LRB-
cord-334907-l4jjb93l	332	17	Invitrogen	Invitrogen	NNP
cord-334907-l4jjb93l	332	18	,	,	,
cord-334907-l4jjb93l	332	19	Carlsbad	Carlsbad	NNP
cord-334907-l4jjb93l	332	20	,	,	,
cord-334907-l4jjb93l	332	21	California	California	NNP
cord-334907-l4jjb93l	332	22	,	,	,
cord-334907-l4jjb93l	332	23	USA	USA	NNP
cord-334907-l4jjb93l	332	24	)	)	-RRB-
cord-334907-l4jjb93l	332	25	using	use	VBG
cord-334907-l4jjb93l	332	26	500	500	CD
cord-334907-l4jjb93l	332	27	ng	ng	NNP
cord-334907-l4jjb93l	332	28	of	of	IN
cord-334907-l4jjb93l	332	29	oligo	oligo	NNP
cord-334907-l4jjb93l	332	30	(	(	-LRB-
cord-334907-l4jjb93l	332	31	dT	dT	NNP
cord-334907-l4jjb93l	332	32	)	)	-RRB-
cord-334907-l4jjb93l	332	33	12	12	CD
cord-334907-l4jjb93l	332	34	-	-	SYM
cord-334907-l4jjb93l	332	35	18	18	CD
cord-334907-l4jjb93l	332	36	,	,	,
cord-334907-l4jjb93l	332	37	1	1	CD
cord-334907-l4jjb93l	332	38	mM	mm	CD
cord-334907-l4jjb93l	332	39	of	of	IN
cord-334907-l4jjb93l	332	40	each	each	DT
cord-334907-l4jjb93l	332	41	dNTP	dntp	NN
cord-334907-l4jjb93l	332	42	,	,	,
cord-334907-l4jjb93l	332	43	and	and	CC
cord-334907-l4jjb93l	332	44	200	200	CD
cord-334907-l4jjb93l	332	45	U	u	NN
cord-334907-l4jjb93l	332	46	of	of	IN
cord-334907-l4jjb93l	332	47	M	M	NNP
cord-334907-l4jjb93l	332	48	-	-	HYPH
cord-334907-l4jjb93l	332	49	MLV	MLV	NNP
cord-334907-l4jjb93l	332	50	Reverse	Reverse	NNP
cord-334907-l4jjb93l	332	51	Transcriptase	Transcriptase	NNP
cord-334907-l4jjb93l	332	52	according	accord	VBG
cord-334907-l4jjb93l	332	53	to	to	IN
cord-334907-l4jjb93l	332	54	the	the	DT
cord-334907-l4jjb93l	332	55	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	332	56	's	's	POS
cord-334907-l4jjb93l	332	57	instructions	instruction	NNS
cord-334907-l4jjb93l	332	58	.	.	.
cord-334907-l4jjb93l	333	1	The	the	DT
cord-334907-l4jjb93l	333	2	ISAV	ISAV	NNP
cord-334907-l4jjb93l	333	3	HPR3	HPR3	NNP
cord-334907-l4jjb93l	333	4	HE	HE	NNP
cord-334907-l4jjb93l	333	5	and	and	CC
cord-334907-l4jjb93l	333	6	F	F	NNP
cord-334907-l4jjb93l	333	7	genes	gene	NNS
cord-334907-l4jjb93l	333	8	(	(	-LRB-
cord-334907-l4jjb93l	333	9	HE3	HE3	NNP
cord-334907-l4jjb93l	333	10	and	and	CC
cord-334907-l4jjb93l	333	11	F3	F3	NNP
cord-334907-l4jjb93l	333	12	,	,	,
cord-334907-l4jjb93l	333	13	respectively	respectively	RB
cord-334907-l4jjb93l	333	14	)	)	-RRB-
cord-334907-l4jjb93l	333	15	and	and	CC
cord-334907-l4jjb93l	333	16	the	the	DT
cord-334907-l4jjb93l	333	17	ISAV	ISAV	NNP
cord-334907-l4jjb93l	333	18	HPR0	HPR0	NNP
cord-334907-l4jjb93l	333	19	HE	HE	NNP
cord-334907-l4jjb93l	333	20	gene	gene	NN
cord-334907-l4jjb93l	333	21	(	(	-LRB-
cord-334907-l4jjb93l	333	22	HE0	HE0	NNP
cord-334907-l4jjb93l	333	23	)	)	-RRB-
cord-334907-l4jjb93l	333	24	were	be	VBD
cord-334907-l4jjb93l	333	25	amplified	amplify	VBN
cord-334907-l4jjb93l	333	26	through	through	IN
cord-334907-l4jjb93l	333	27	polymerase	polymerase	NN
cord-334907-l4jjb93l	333	28	chain	chain	NN
cord-334907-l4jjb93l	333	29	reaction	reaction	NN
cord-334907-l4jjb93l	333	30	(	(	-LRB-
cord-334907-l4jjb93l	333	31	PCR	PCR	NNP
cord-334907-l4jjb93l	333	32	)	)	-RRB-
cord-334907-l4jjb93l	333	33	using	use	VBG
cord-334907-l4jjb93l	333	34	the	the	DT
cord-334907-l4jjb93l	333	35	corresponding	correspond	VBG
cord-334907-l4jjb93l	333	36	cDNA	cdna	NN
cord-334907-l4jjb93l	333	37	as	as	IN
cord-334907-l4jjb93l	333	38	template	template	NN
cord-334907-l4jjb93l	333	39	and	and	CC
cord-334907-l4jjb93l	333	40	cloned	clone	VBN
cord-334907-l4jjb93l	333	41	in	in	IN
cord-334907-l4jjb93l	333	42	an	an	DT
cord-334907-l4jjb93l	333	43	appropriate	appropriate	JJ
cord-334907-l4jjb93l	333	44	expression	expression	NN
cord-334907-l4jjb93l	333	45	vector	vector	NN
cord-334907-l4jjb93l	333	46	.	.	.
cord-334907-l4jjb93l	334	1	In	in	IN
cord-334907-l4jjb93l	334	2	detail	detail	NN
cord-334907-l4jjb93l	334	3	,	,	,
cord-334907-l4jjb93l	334	4	to	to	TO
cord-334907-l4jjb93l	334	5	analyze	analyze	VB
cord-334907-l4jjb93l	334	6	the	the	DT
cord-334907-l4jjb93l	334	7	influence	influence	NN
cord-334907-l4jjb93l	334	8	of	of	IN
cord-334907-l4jjb93l	334	9	the	the	DT
cord-334907-l4jjb93l	334	10	esterase	esterase	NN
cord-334907-l4jjb93l	334	11	in	in	IN
cord-334907-l4jjb93l	334	12	HPR0	HPR0	NNP
cord-334907-l4jjb93l	334	13	HE	HE	NNP
cord-334907-l4jjb93l	334	14	and	and	CC
cord-334907-l4jjb93l	334	15	the	the	DT
cord-334907-l4jjb93l	334	16	influence	influence	NN
cord-334907-l4jjb93l	334	17	of	of	IN
cord-334907-l4jjb93l	334	18	amino	amino	JJ
cord-334907-l4jjb93l	334	19	acids	acid	NNS
cord-334907-l4jjb93l	334	20	Phe	Phe	NNP
cord-334907-l4jjb93l	334	21	189	189	CD
cord-334907-l4jjb93l	334	22	and	and	CC
cord-334907-l4jjb93l	334	23	Phe	Phe	NNP
cord-334907-l4jjb93l	334	24	227	227	CD
cord-334907-l4jjb93l	334	25	in	in	IN
cord-334907-l4jjb93l	334	26	F	F	NNP
cord-334907-l4jjb93l	334	27	1	1	CD
cord-334907-l4jjb93l	334	28	over	over	IN
cord-334907-l4jjb93l	334	29	the	the	DT
cord-334907-l4jjb93l	334	30	fusion	fusion	NN
cord-334907-l4jjb93l	334	31	process	process	NN
cord-334907-l4jjb93l	334	32	,	,	,
cord-334907-l4jjb93l	334	33	point	point	NN
cord-334907-l4jjb93l	334	34	mutations	mutation	NNS
cord-334907-l4jjb93l	334	35	were	be	VBD
cord-334907-l4jjb93l	334	36	added	add	VBN
cord-334907-l4jjb93l	334	37	to	to	IN
cord-334907-l4jjb93l	334	38	the	the	DT
cord-334907-l4jjb93l	334	39	open	open	JJ
cord-334907-l4jjb93l	334	40	reading	reading	NN
cord-334907-l4jjb93l	334	41	frames	frame	NNS
cord-334907-l4jjb93l	334	42	(	(	-LRB-
cord-334907-l4jjb93l	334	43	ORFs	ORFs	NNP
cord-334907-l4jjb93l	334	44	)	)	-RRB-
cord-334907-l4jjb93l	334	45	,	,	,
cord-334907-l4jjb93l	334	46	using	use	VBG
cord-334907-l4jjb93l	334	47	overlap	overlap	NN
cord-334907-l4jjb93l	334	48	extension	extension	NN
cord-334907-l4jjb93l	334	49	PCR	PCR	NNP
cord-334907-l4jjb93l	334	50	(	(	-LRB-
cord-334907-l4jjb93l	334	51	OE	OE	NNP
cord-334907-l4jjb93l	334	52	-	-	HYPH
cord-334907-l4jjb93l	334	53	PCR	PCR	NNP
cord-334907-l4jjb93l	334	54	)	)	-RRB-
cord-334907-l4jjb93l	334	55	[	[	-LRB-
cord-334907-l4jjb93l	334	56	60	60	CD
cord-334907-l4jjb93l	334	57	]	]	-RRB-
cord-334907-l4jjb93l	334	58	.	.	.
cord-334907-l4jjb93l	335	1	The	the	DT
cord-334907-l4jjb93l	335	2	ORFs	ORFs	NNP
cord-334907-l4jjb93l	335	3	for	for	IN
cord-334907-l4jjb93l	335	4	eGFP	egfp	NN
cord-334907-l4jjb93l	335	5	and	and	CC
cord-334907-l4jjb93l	335	6	mCherry	mCherry	NNP
cord-334907-l4jjb93l	335	7	were	be	VBD
cord-334907-l4jjb93l	335	8	added	add	VBN
cord-334907-l4jjb93l	335	9	to	to	IN
cord-334907-l4jjb93l	335	10	the	the	DT
cord-334907-l4jjb93l	335	11	3	3	CD
cord-334907-l4jjb93l	335	12	end	end	NN
cord-334907-l4jjb93l	335	13	of	of	IN
cord-334907-l4jjb93l	335	14	the	the	DT
cord-334907-l4jjb93l	335	15	HE	HE	NNP
cord-334907-l4jjb93l	335	16	and	and	CC
cord-334907-l4jjb93l	335	17	F	F	NNP
cord-334907-l4jjb93l	335	18	ORFs	ORFs	NNP
cord-334907-l4jjb93l	335	19	,	,	,
cord-334907-l4jjb93l	335	20	respectively	respectively	RB
cord-334907-l4jjb93l	335	21	,	,	,
cord-334907-l4jjb93l	335	22	to	to	TO
cord-334907-l4jjb93l	335	23	obtain	obtain	VB
cord-334907-l4jjb93l	335	24	fusion	fusion	NN
cord-334907-l4jjb93l	335	25	proteins	protein	NNS
cord-334907-l4jjb93l	335	26	and	and	CC
cord-334907-l4jjb93l	335	27	directly	directly	RB
cord-334907-l4jjb93l	335	28	evaluate	evaluate	VB
cord-334907-l4jjb93l	335	29	the	the	DT
cord-334907-l4jjb93l	335	30	construct	construct	NN
cord-334907-l4jjb93l	335	31	's	's	POS
cord-334907-l4jjb93l	335	32	expression	expression	NN
cord-334907-l4jjb93l	335	33	.	.	.
cord-334907-l4jjb93l	336	1	An	an	DT
cord-334907-l4jjb93l	336	2	overview	overview	NN
cord-334907-l4jjb93l	336	3	of	of	IN
cord-334907-l4jjb93l	336	4	the	the	DT
cord-334907-l4jjb93l	336	5	different	different	JJ
cord-334907-l4jjb93l	336	6	constructs	construct	NNS
cord-334907-l4jjb93l	336	7	is	be	VBZ
cord-334907-l4jjb93l	336	8	presented	present	VBN
cord-334907-l4jjb93l	336	9	in	in	IN
cord-334907-l4jjb93l	336	10	Table	Table	NNP
cord-334907-l4jjb93l	336	11	1	1	CD
cord-334907-l4jjb93l	336	12	.	.	.
cord-334907-l4jjb93l	337	1	The	the	DT
cord-334907-l4jjb93l	337	2	wild	wild	JJ
cord-334907-l4jjb93l	337	3	type	type	NN
cord-334907-l4jjb93l	337	4	(	(	-LRB-
cord-334907-l4jjb93l	337	5	WT	WT	NNP
cord-334907-l4jjb93l	337	6	)	)	-RRB-
cord-334907-l4jjb93l	337	7	,	,	,
cord-334907-l4jjb93l	337	8	mutated	mutate	VBN
cord-334907-l4jjb93l	337	9	,	,	,
cord-334907-l4jjb93l	337	10	and	and	CC
cord-334907-l4jjb93l	337	11	fusion	fusion	NN
cord-334907-l4jjb93l	337	12	ORFs	orf	NNS
cord-334907-l4jjb93l	337	13	were	be	VBD
cord-334907-l4jjb93l	337	14	cloned	clone	VBN
cord-334907-l4jjb93l	337	15	in	in	IN
cord-334907-l4jjb93l	337	16	the	the	DT
cord-334907-l4jjb93l	337	17	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	337	18	-	-	HYPH
cord-334907-l4jjb93l	337	19	CMV14	CMV14	NNP
cord-334907-l4jjb93l	337	20	vector	vector	NN
cord-334907-l4jjb93l	337	21	(	(	-LRB-
cord-334907-l4jjb93l	337	22	Sigma	Sigma	NNP
cord-334907-l4jjb93l	337	23	-	-	HYPH
cord-334907-l4jjb93l	337	24	Aldrich	Aldrich	NNP
cord-334907-l4jjb93l	337	25	,	,	,
cord-334907-l4jjb93l	337	26	St.	St.	NNP
cord-334907-l4jjb93l	337	27	Louis	Louis	NNP
cord-334907-l4jjb93l	337	28	,	,	,
cord-334907-l4jjb93l	337	29	Missouri	Missouri	NNP
cord-334907-l4jjb93l	337	30	,	,	,
cord-334907-l4jjb93l	337	31	USA	USA	NNP
cord-334907-l4jjb93l	337	32	)	)	-RRB-
cord-334907-l4jjb93l	337	33	.	.	.
cord-334907-l4jjb93l	338	1	Accordingly	accordingly	RB
cord-334907-l4jjb93l	338	2	,	,	,
cord-334907-l4jjb93l	338	3	primers	primer	NNS
cord-334907-l4jjb93l	338	4	were	be	VBD
cord-334907-l4jjb93l	338	5	designed	design	VBN
cord-334907-l4jjb93l	338	6	for	for	IN
cord-334907-l4jjb93l	338	7	each	each	DT
cord-334907-l4jjb93l	338	8	process	process	NN
cord-334907-l4jjb93l	338	9	(	(	-LRB-
cord-334907-l4jjb93l	338	10	Table	table	NN
cord-334907-l4jjb93l	338	11	2	2	CD
cord-334907-l4jjb93l	338	12	)	)	-RRB-
cord-334907-l4jjb93l	338	13	.	.	.
cord-334907-l4jjb93l	339	1	The	the	DT
cord-334907-l4jjb93l	339	2	PCR	PCR	NNP
cord-334907-l4jjb93l	339	3	reactions	reaction	NNS
cord-334907-l4jjb93l	339	4	were	be	VBD
cord-334907-l4jjb93l	339	5	performed	perform	VBN
cord-334907-l4jjb93l	339	6	in	in	IN
cord-334907-l4jjb93l	339	7	a	a	DT
cord-334907-l4jjb93l	339	8	20	20	CD
cord-334907-l4jjb93l	339	9	µL	µL	NNP
cord-334907-l4jjb93l	339	10	total	total	JJ
cord-334907-l4jjb93l	339	11	volume	volume	NN
cord-334907-l4jjb93l	339	12	using	use	VBG
cord-334907-l4jjb93l	339	13	a	a	DT
cord-334907-l4jjb93l	339	14	1	1	CD
cord-334907-l4jjb93l	339	15	µL	µL	NNP
cord-334907-l4jjb93l	339	16	cDNA	cdna	NN
cord-334907-l4jjb93l	339	17	sample	sample	NN
cord-334907-l4jjb93l	339	18	as	as	IN
cord-334907-l4jjb93l	339	19	template	template	NN
cord-334907-l4jjb93l	339	20	,	,	,
cord-334907-l4jjb93l	339	21	with	with	IN
cord-334907-l4jjb93l	339	22	1X	1x	JJ
cord-334907-l4jjb93l	339	23	HF	HF	NNP
cord-334907-l4jjb93l	339	24	Phusion	Phusion	NNP
cord-334907-l4jjb93l	339	25	Buffer	Buffer	NNP
cord-334907-l4jjb93l	339	26	(	(	-LRB-
cord-334907-l4jjb93l	339	27	NEB	NEB	NNP
cord-334907-l4jjb93l	339	28	,	,	,
cord-334907-l4jjb93l	339	29	Ipswich	Ipswich	NNP
cord-334907-l4jjb93l	339	30	,	,	,
cord-334907-l4jjb93l	339	31	MA	MA	NNP
cord-334907-l4jjb93l	339	32	,	,	,
cord-334907-l4jjb93l	339	33	USA	USA	NNP
cord-334907-l4jjb93l	339	34	)	)	-RRB-
cord-334907-l4jjb93l	339	35	,	,	,
cord-334907-l4jjb93l	339	36	200	200	CD
cord-334907-l4jjb93l	339	37	µM	µM	NNP
cord-334907-l4jjb93l	339	38	dNTPs	dntps	CD
cord-334907-l4jjb93l	339	39	,	,	,
cord-334907-l4jjb93l	339	40	500	500	CD
cord-334907-l4jjb93l	339	41	nM	nm	CD
cord-334907-l4jjb93l	339	42	of	of	IN
cord-334907-l4jjb93l	339	43	each	each	DT
cord-334907-l4jjb93l	339	44	primer	primer	NN
cord-334907-l4jjb93l	339	45	,	,	,
cord-334907-l4jjb93l	339	46	1	1	CD
cord-334907-l4jjb93l	339	47	M	M	NNP
cord-334907-l4jjb93l	339	48	betaine	betaine	NN
cord-334907-l4jjb93l	339	49	,	,	,
cord-334907-l4jjb93l	339	50	and	and	CC
cord-334907-l4jjb93l	339	51	1	1	CD
cord-334907-l4jjb93l	339	52	U	u	NN
cord-334907-l4jjb93l	339	53	of	of	IN
cord-334907-l4jjb93l	339	54	Phusion	Phusion	NNP
cord-334907-l4jjb93l	339	55	DNA	DNA	NNP
cord-334907-l4jjb93l	339	56	Polymerase	Polymerase	NNP
cord-334907-l4jjb93l	339	57	(	(	-LRB-
cord-334907-l4jjb93l	339	58	NEB	NEB	NNP
cord-334907-l4jjb93l	339	59	,	,	,
cord-334907-l4jjb93l	339	60	Ipswich	Ipswich	NNP
cord-334907-l4jjb93l	339	61	,	,	,
cord-334907-l4jjb93l	339	62	MA	MA	NNP
cord-334907-l4jjb93l	339	63	,	,	,
cord-334907-l4jjb93l	339	64	USA	USA	NNP
cord-334907-l4jjb93l	339	65	)	)	-RRB-
cord-334907-l4jjb93l	339	66	.	.	.
cord-334907-l4jjb93l	340	1	Thermal	thermal	JJ
cord-334907-l4jjb93l	340	2	conditions	condition	NNS
cord-334907-l4jjb93l	340	3	used	use	VBN
cord-334907-l4jjb93l	340	4	for	for	IN
cord-334907-l4jjb93l	340	5	PCR	PCR	NNP
cord-334907-l4jjb93l	340	6	reactions	reaction	NNS
cord-334907-l4jjb93l	340	7	were	be	VBD
cord-334907-l4jjb93l	340	8	as	as	IN
cord-334907-l4jjb93l	340	9	follows	follow	VBZ
cord-334907-l4jjb93l	340	10	:	:	:
cord-334907-l4jjb93l	340	11	3	3	CD
cord-334907-l4jjb93l	340	12	min	min	NN
cord-334907-l4jjb93l	340	13	at	at	IN
cord-334907-l4jjb93l	340	14	95	95	CD
cord-334907-l4jjb93l	340	15	•	•	NN
cord-334907-l4jjb93l	340	16	C	c	NN
cord-334907-l4jjb93l	340	17	,	,	,
cord-334907-l4jjb93l	340	18	followed	follow	VBN
cord-334907-l4jjb93l	340	19	by	by	IN
cord-334907-l4jjb93l	340	20	40	40	CD
cord-334907-l4jjb93l	340	21	cycles	cycle	NNS
cord-334907-l4jjb93l	340	22	of	of	IN
cord-334907-l4jjb93l	340	23	30	30	CD
cord-334907-l4jjb93l	340	24	s	s	NN
cord-334907-l4jjb93l	340	25	at	at	IN
cord-334907-l4jjb93l	340	26	93	93	CD
cord-334907-l4jjb93l	341	1	•	•	NNP
cord-334907-l4jjb93l	342	1	C	C	NNP
cord-334907-l4jjb93l	342	2	,	,	,
cord-334907-l4jjb93l	342	3	30	30	CD
cord-334907-l4jjb93l	342	4	s	s	NN
cord-334907-l4jjb93l	342	5	at	at	IN
cord-334907-l4jjb93l	342	6	55	55	CD
cord-334907-l4jjb93l	343	1	•	•	NNP
cord-334907-l4jjb93l	343	2	C	C	NNP
cord-334907-l4jjb93l	343	3	,	,	,
cord-334907-l4jjb93l	343	4	and	and	CC
cord-334907-l4jjb93l	343	5	2	2	CD
cord-334907-l4jjb93l	343	6	min	min	NN
cord-334907-l4jjb93l	343	7	at	at	IN
cord-334907-l4jjb93l	343	8	72	72	CD
cord-334907-l4jjb93l	344	1	•	•	NNP
cord-334907-l4jjb93l	344	2	C	C	NNP
cord-334907-l4jjb93l	344	3	,	,	,
cord-334907-l4jjb93l	344	4	with	with	IN
cord-334907-l4jjb93l	344	5	a	a	DT
cord-334907-l4jjb93l	344	6	final	final	JJ
cord-334907-l4jjb93l	344	7	extension	extension	NN
cord-334907-l4jjb93l	344	8	stage	stage	NN
cord-334907-l4jjb93l	344	9	of	of	IN
cord-334907-l4jjb93l	344	10	5	5	CD
cord-334907-l4jjb93l	344	11	min	min	NN
cord-334907-l4jjb93l	344	12	at	at	IN
cord-334907-l4jjb93l	344	13	72	72	CD
cord-334907-l4jjb93l	345	1	•	•	NNP
cord-334907-l4jjb93l	346	1	C.	C.	NNP
cord-334907-l4jjb93l	346	2	PCR	PCR	NNP
cord-334907-l4jjb93l	346	3	products	product	NNS
cord-334907-l4jjb93l	346	4	were	be	VBD
cord-334907-l4jjb93l	346	5	cloned	clone	VBN
cord-334907-l4jjb93l	346	6	in	in	IN
cord-334907-l4jjb93l	346	7	the	the	DT
cord-334907-l4jjb93l	346	8	pJET	pjet	JJ
cord-334907-l4jjb93l	346	9	1.2	1.2	CD
cord-334907-l4jjb93l	346	10	/	/	SYM
cord-334907-l4jjb93l	346	11	Blunt	Blunt	NNP
cord-334907-l4jjb93l	346	12	vector	vector	NN
cord-334907-l4jjb93l	346	13	using	use	VBG
cord-334907-l4jjb93l	346	14	the	the	DT
cord-334907-l4jjb93l	346	15	CloneJET	CloneJET	NNP
cord-334907-l4jjb93l	346	16	PCR	PCR	NNP
cord-334907-l4jjb93l	346	17	Cloning	Cloning	NNP
cord-334907-l4jjb93l	346	18	Kit	kit	NN
cord-334907-l4jjb93l	346	19	(	(	-LRB-
cord-334907-l4jjb93l	346	20	Thermo	Thermo	NNP
cord-334907-l4jjb93l	346	21	Fisher	Fisher	NNP
cord-334907-l4jjb93l	346	22	,	,	,
cord-334907-l4jjb93l	346	23	Waltham	Waltham	NNP
cord-334907-l4jjb93l	346	24	,	,	,
cord-334907-l4jjb93l	346	25	MA	MA	NNP
cord-334907-l4jjb93l	346	26	,	,	,
cord-334907-l4jjb93l	346	27	USA	USA	NNP
cord-334907-l4jjb93l	346	28	)	)	-RRB-
cord-334907-l4jjb93l	346	29	according	accord	VBG
cord-334907-l4jjb93l	346	30	to	to	IN
cord-334907-l4jjb93l	346	31	the	the	DT
cord-334907-l4jjb93l	346	32	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	346	33	's	's	POS
cord-334907-l4jjb93l	346	34	instructions	instruction	NNS
cord-334907-l4jjb93l	346	35	.	.	.
cord-334907-l4jjb93l	347	1	After	after	IN
cord-334907-l4jjb93l	347	2	digestion	digestion	NN
cord-334907-l4jjb93l	347	3	with	with	IN
cord-334907-l4jjb93l	347	4	specific	specific	JJ
cord-334907-l4jjb93l	347	5	restriction	restriction	NN
cord-334907-l4jjb93l	347	6	enzymes	enzyme	NNS
cord-334907-l4jjb93l	347	7	(	(	-LRB-
cord-334907-l4jjb93l	347	8	Promega	Promega	NNP
cord-334907-l4jjb93l	347	9	,	,	,
cord-334907-l4jjb93l	347	10	Madison	Madison	NNP
cord-334907-l4jjb93l	347	11	,	,	,
cord-334907-l4jjb93l	347	12	Wisconsin	Wisconsin	NNP
cord-334907-l4jjb93l	347	13	,	,	,
cord-334907-l4jjb93l	347	14	USA	USA	NNP
cord-334907-l4jjb93l	347	15	)	)	-RRB-
cord-334907-l4jjb93l	347	16	and	and	CC
cord-334907-l4jjb93l	347	17	gel	gel	NN
cord-334907-l4jjb93l	347	18	electrophoresis	electrophoresis	NN
cord-334907-l4jjb93l	347	19	,	,	,
cord-334907-l4jjb93l	347	20	gene	gene	NN
cord-334907-l4jjb93l	347	21	fragments	fragment	NNS
cord-334907-l4jjb93l	347	22	and	and	CC
cord-334907-l4jjb93l	347	23	the	the	DT
cord-334907-l4jjb93l	347	24	linearized	linearize	VBN
cord-334907-l4jjb93l	347	25	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	347	26	-	-	HYPH
cord-334907-l4jjb93l	347	27	CMV14	CMV14	NNP
cord-334907-l4jjb93l	347	28	vector	vector	NN
cord-334907-l4jjb93l	347	29	were	be	VBD
cord-334907-l4jjb93l	347	30	purified	purify	VBN
cord-334907-l4jjb93l	347	31	with	with	IN
cord-334907-l4jjb93l	347	32	the	the	DT
cord-334907-l4jjb93l	347	33	GeneJET	GeneJET	NNS
cord-334907-l4jjb93l	347	34	Gel	Gel	NNP
cord-334907-l4jjb93l	347	35	Extraction	Extraction	NNP
cord-334907-l4jjb93l	347	36	Kit	kit	NN
cord-334907-l4jjb93l	347	37	(	(	-LRB-
cord-334907-l4jjb93l	347	38	Thermo	Thermo	NNP
cord-334907-l4jjb93l	347	39	Fisher	Fisher	NNP
cord-334907-l4jjb93l	347	40	,	,	,
cord-334907-l4jjb93l	347	41	Waltham	Waltham	NNP
cord-334907-l4jjb93l	347	42	,	,	,
cord-334907-l4jjb93l	347	43	MA	MA	NNP
cord-334907-l4jjb93l	347	44	,	,	,
cord-334907-l4jjb93l	347	45	USA	USA	NNP
cord-334907-l4jjb93l	347	46	)	)	-RRB-
cord-334907-l4jjb93l	347	47	.	.	.
cord-334907-l4jjb93l	348	1	For	for	IN
cord-334907-l4jjb93l	348	2	cloning	clone	VBG
cord-334907-l4jjb93l	348	3	in	in	IN
cord-334907-l4jjb93l	348	4	the	the	DT
cord-334907-l4jjb93l	348	5	p3xFLAG	p3xFLAG	NNP
cord-334907-l4jjb93l	348	6	-	-	HYPH
cord-334907-l4jjb93l	348	7	CMV14	CMV14	NNP
cord-334907-l4jjb93l	348	8	vector	vector	NN
cord-334907-l4jjb93l	348	9	,	,	,
cord-334907-l4jjb93l	348	10	a	a	DT
cord-334907-l4jjb93l	348	11	mixture	mixture	NN
cord-334907-l4jjb93l	348	12	containing	contain	VBG
cord-334907-l4jjb93l	348	13	10	10	CD
cord-334907-l4jjb93l	348	14	ng	ng	NN
cord-334907-l4jjb93l	348	15	of	of	IN
cord-334907-l4jjb93l	348	16	the	the	DT
cord-334907-l4jjb93l	348	17	digested	digest	VBN
cord-334907-l4jjb93l	348	18	expression	expression	NN
cord-334907-l4jjb93l	348	19	vector	vector	NN
cord-334907-l4jjb93l	348	20	and	and	CC
cord-334907-l4jjb93l	348	21	100	100	CD
cord-334907-l4jjb93l	348	22	ng	ng	NN
cord-334907-l4jjb93l	348	23	of	of	IN
cord-334907-l4jjb93l	348	24	the	the	DT
cord-334907-l4jjb93l	348	25	digested	digest	VBN
cord-334907-l4jjb93l	348	26	HE	HE	NNP
cord-334907-l4jjb93l	348	27	or	or	CC
cord-334907-l4jjb93l	348	28	F	F	NNP
cord-334907-l4jjb93l	348	29	gene	gene	NN
cord-334907-l4jjb93l	348	30	inserts	insert	NNS
cord-334907-l4jjb93l	348	31	were	be	VBD
cord-334907-l4jjb93l	348	32	ligated	ligate	VBN
cord-334907-l4jjb93l	348	33	using	use	VBG
cord-334907-l4jjb93l	348	34	the	the	DT
cord-334907-l4jjb93l	348	35	Rapid	Rapid	NNP
cord-334907-l4jjb93l	348	36	DNA	DNA	NNP
cord-334907-l4jjb93l	348	37	Ligation	Ligation	NNP
cord-334907-l4jjb93l	348	38	Kit	kit	NN
cord-334907-l4jjb93l	348	39	(	(	-LRB-
cord-334907-l4jjb93l	348	40	Thermo	Thermo	NNP
cord-334907-l4jjb93l	348	41	Fisher	Fisher	NNP
cord-334907-l4jjb93l	348	42	,	,	,
cord-334907-l4jjb93l	348	43	Waltham	Waltham	NNP
cord-334907-l4jjb93l	348	44	,	,	,
cord-334907-l4jjb93l	348	45	MA	MA	NNP
cord-334907-l4jjb93l	348	46	,	,	,
cord-334907-l4jjb93l	348	47	USA	USA	NNP
cord-334907-l4jjb93l	348	48	)	)	-RRB-
cord-334907-l4jjb93l	348	49	according	accord	VBG
cord-334907-l4jjb93l	348	50	to	to	IN
cord-334907-l4jjb93l	348	51	the	the	DT
cord-334907-l4jjb93l	348	52	manufacturer	manufacturer	NN
cord-334907-l4jjb93l	348	53	's	's	POS
cord-334907-l4jjb93l	348	54	instructions	instruction	NNS
cord-334907-l4jjb93l	348	55	.	.	.
cord-334907-l4jjb93l	349	1	Recombinant	recombinant	JJ
cord-334907-l4jjb93l	349	2	plasmids	plasmid	NNS
cord-334907-l4jjb93l	349	3	(	(	-LRB-
cord-334907-l4jjb93l	349	4	pDNA	pdna	RB
cord-334907-l4jjb93l	349	5	)	)	-RRB-
cord-334907-l4jjb93l	349	6	were	be	VBD
cord-334907-l4jjb93l	349	7	isolated	isolate	VBN
cord-334907-l4jjb93l	349	8	using	use	VBG
cord-334907-l4jjb93l	349	9	the	the	DT
cord-334907-l4jjb93l	349	10	GeneJET	GeneJET	``
cord-334907-l4jjb93l	349	11	Plasmid	Plasmid	NNP
cord-334907-l4jjb93l	349	12	DNA	DNA	NNP
cord-334907-l4jjb93l	349	13	Kit	kit	NN
cord-334907-l4jjb93l	349	14	(	(	-LRB-
cord-334907-l4jjb93l	349	15	Thermo	Thermo	NNP
cord-334907-l4jjb93l	349	16	Fisher	Fisher	NNP
cord-334907-l4jjb93l	349	17	,	,	,
cord-334907-l4jjb93l	349	18	Waltham	Waltham	NNP
cord-334907-l4jjb93l	349	19	,	,	,
cord-334907-l4jjb93l	349	20	MA	MA	NNP
cord-334907-l4jjb93l	349	21	,	,	,
cord-334907-l4jjb93l	349	22	USA	USA	NNP
cord-334907-l4jjb93l	349	23	)	)	-RRB-
cord-334907-l4jjb93l	349	24	from	from	IN
cord-334907-l4jjb93l	349	25	transformed	transform	VBN
cord-334907-l4jjb93l	349	26	DH5α	DH5α	NNP
cord-334907-l4jjb93l	349	27	cells	cell	NNS
cord-334907-l4jjb93l	349	28	grown	grow	VBN
cord-334907-l4jjb93l	349	29	in	in	IN
cord-334907-l4jjb93l	349	30	LB	LB	NNP
cord-334907-l4jjb93l	349	31	broth	broth	NN
cord-334907-l4jjb93l	349	32	.	.	.
cord-334907-l4jjb93l	350	1	The	the	DT
cord-334907-l4jjb93l	350	2	cloned	clone	VBN
cord-334907-l4jjb93l	350	3	sequences	sequence	NNS
cord-334907-l4jjb93l	350	4	and	and	CC
cord-334907-l4jjb93l	350	5	expression	expression	NN
cord-334907-l4jjb93l	350	6	constructs	construct	NNS
cord-334907-l4jjb93l	350	7	were	be	VBD
cord-334907-l4jjb93l	350	8	verified	verify	VBN
cord-334907-l4jjb93l	350	9	by	by	IN
cord-334907-l4jjb93l	350	10	sequencing	sequence	VBG
cord-334907-l4jjb93l	350	11	(	(	-LRB-
cord-334907-l4jjb93l	350	12	Macrogen	Macrogen	NNP
cord-334907-l4jjb93l	350	13	,	,	,
cord-334907-l4jjb93l	350	14	Seoul	Seoul	NNP
cord-334907-l4jjb93l	350	15	,	,	,
cord-334907-l4jjb93l	350	16	Korea	Korea	NNP
cord-334907-l4jjb93l	350	17	)	)	-RRB-
cord-334907-l4jjb93l	350	18	using	use	VBG
cord-334907-l4jjb93l	350	19	the	the	DT
cord-334907-l4jjb93l	350	20	cmv30F	cmv30F	NNP
cord-334907-l4jjb93l	350	21	and	and	CC
cord-334907-l4jjb93l	350	22	cmv24R	cmv24R	NNP
cord-334907-l4jjb93l	350	23	primers	primer	NNS
cord-334907-l4jjb93l	350	24	.	.	.
cord-334907-l4jjb93l	351	1	Exponentially	exponentially	RB
cord-334907-l4jjb93l	351	2	growing	grow	VBG
cord-334907-l4jjb93l	351	3	CHSE	CHSE	NNP
cord-334907-l4jjb93l	351	4	/	/	SYM
cord-334907-l4jjb93l	351	5	F	F	NNP
cord-334907-l4jjb93l	351	6	cells	cell	NNS
cord-334907-l4jjb93l	351	7	were	be	VBD
cord-334907-l4jjb93l	351	8	seeded	seed	VBN
cord-334907-l4jjb93l	351	9	on	on	IN
cord-334907-l4jjb93l	351	10	glass	glass	NN
cord-334907-l4jjb93l	351	11	bottom	bottom	NN
cord-334907-l4jjb93l	351	12	35	35	CD
cord-334907-l4jjb93l	351	13	mm	mm	CD
cord-334907-l4jjb93l	351	14	2	2	CD
cord-334907-l4jjb93l	351	15	dishes	dish	NNS
cord-334907-l4jjb93l	351	16	and	and	CC
cord-334907-l4jjb93l	351	17	cultured	cultured	JJ
cord-334907-l4jjb93l	351	18	overnight	overnight	RB
cord-334907-l4jjb93l	351	19	,	,	,
cord-334907-l4jjb93l	351	20	as	as	IN
cord-334907-l4jjb93l	351	21	described	describe	VBN
cord-334907-l4jjb93l	351	22	above	above	RB
cord-334907-l4jjb93l	351	23	.	.	.
cord-334907-l4jjb93l	352	1	Cells	cell	NNS
cord-334907-l4jjb93l	352	2	were	be	VBD
cord-334907-l4jjb93l	352	3	washed	wash	VBN
cord-334907-l4jjb93l	352	4	twice	twice	RB
cord-334907-l4jjb93l	352	5	with	with	IN
cord-334907-l4jjb93l	352	6	PBS	PBS	NNP
cord-334907-l4jjb93l	352	7	and	and	CC
cord-334907-l4jjb93l	352	8	then	then	RB
cord-334907-l4jjb93l	352	9	incubated	incubate	VBD
cord-334907-l4jjb93l	352	10	in	in	IN
cord-334907-l4jjb93l	352	11	L-15	L-15	NNP
cord-334907-l4jjb93l	352	12	medium	medium	NN
cord-334907-l4jjb93l	352	13	.	.	.
cord-334907-l4jjb93l	353	1	A	a	DT
cord-334907-l4jjb93l	353	2	transfection	transfection	NN
cord-334907-l4jjb93l	353	3	mixture	mixture	NN
cord-334907-l4jjb93l	353	4	was	be	VBD
cord-334907-l4jjb93l	353	5	prepared	prepare	VBN
cord-334907-l4jjb93l	353	6	for	for	IN
cord-334907-l4jjb93l	353	7	each	each	DT
cord-334907-l4jjb93l	353	8	dish	dish	NN
cord-334907-l4jjb93l	353	9	,	,	,
cord-334907-l4jjb93l	353	10	diluting	dilute	VBG
cord-334907-l4jjb93l	353	11	transfection	transfection	NN
cord-334907-l4jjb93l	353	12	reagent	reagent	NN
cord-334907-l4jjb93l	353	13	FuGENE	FuGENE	NNP
cord-334907-l4jjb93l	353	14	(	(	-LRB-
cord-334907-l4jjb93l	353	15	Promega	Promega	NNP
cord-334907-l4jjb93l	353	16	,	,	,
cord-334907-l4jjb93l	353	17	Madison	Madison	NNP
cord-334907-l4jjb93l	353	18	,	,	,
cord-334907-l4jjb93l	353	19	Wisconsin	Wisconsin	NNP
cord-334907-l4jjb93l	353	20	,	,	,
cord-334907-l4jjb93l	353	21	USA	USA	NNP
cord-334907-l4jjb93l	353	22	)	)	-RRB-
cord-334907-l4jjb93l	353	23	in	in	IN
cord-334907-l4jjb93l	353	24	100	100	CD
cord-334907-l4jjb93l	353	25	µL	µl	CD
cord-334907-l4jjb93l	353	26	of	of	IN
cord-334907-l4jjb93l	353	27	L-15	L-15	NNP
cord-334907-l4jjb93l	353	28	medium	medium	NN
cord-334907-l4jjb93l	353	29	and	and	CC
cord-334907-l4jjb93l	353	30	then	then	RB
cord-334907-l4jjb93l	353	31	adding	add	VBG
cord-334907-l4jjb93l	353	32	pDNA	pdna	RB
cord-334907-l4jjb93l	353	33	of	of	IN
cord-334907-l4jjb93l	353	34	the	the	DT
cord-334907-l4jjb93l	353	35	HE	HE	NNP
cord-334907-l4jjb93l	353	36	and/or	and/or	CC
cord-334907-l4jjb93l	353	37	F	F	NNP
cord-334907-l4jjb93l	353	38	expression	expression	NN
cord-334907-l4jjb93l	353	39	constructs	construct	VBZ
cord-334907-l4jjb93l	353	40	.	.	.
cord-334907-l4jjb93l	354	1	Here	here	RB
cord-334907-l4jjb93l	354	2	,	,	,
cord-334907-l4jjb93l	354	3	250	250	CD
cord-334907-l4jjb93l	354	4	ng	ng	NN
cord-334907-l4jjb93l	354	5	of	of	IN
cord-334907-l4jjb93l	354	6	the	the	DT
cord-334907-l4jjb93l	354	7	HE	HE	NNP
cord-334907-l4jjb93l	354	8	constructs	construct	VBZ
cord-334907-l4jjb93l	354	9	and/or	and/or	CC
cord-334907-l4jjb93l	354	10	500	500	CD
cord-334907-l4jjb93l	354	11	ng	ng	NN
cord-334907-l4jjb93l	354	12	of	of	IN
cord-334907-l4jjb93l	354	13	the	the	DT
cord-334907-l4jjb93l	354	14	F	F	NNP
cord-334907-l4jjb93l	354	15	constructs	construct	NNS
cord-334907-l4jjb93l	354	16	were	be	VBD
cord-334907-l4jjb93l	354	17	added	add	VBN
cord-334907-l4jjb93l	354	18	to	to	IN
cord-334907-l4jjb93l	354	19	the	the	DT
cord-334907-l4jjb93l	354	20	mixture	mixture	NN
cord-334907-l4jjb93l	354	21	[	[	-LRB-
cord-334907-l4jjb93l	354	22	12	12	CD
cord-334907-l4jjb93l	354	23	]	]	-RRB-
cord-334907-l4jjb93l	354	24	.	.	.
cord-334907-l4jjb93l	355	1	FuGENE	FuGENE	NNP
cord-334907-l4jjb93l	355	2	was	be	VBD
cord-334907-l4jjb93l	355	3	used	use	VBN
cord-334907-l4jjb93l	355	4	in	in	IN
cord-334907-l4jjb93l	355	5	a	a	DT
cord-334907-l4jjb93l	355	6	reagent	reagent	NN
cord-334907-l4jjb93l	355	7	:	:	:
cord-334907-l4jjb93l	355	8	pDNA	pDNA	NNP
cord-334907-l4jjb93l	355	9	(	(	-LRB-
cord-334907-l4jjb93l	355	10	µL:µg	µl:µg	NN
cord-334907-l4jjb93l	355	11	)	)	-RRB-
cord-334907-l4jjb93l	355	12	ratio	ratio	NN
cord-334907-l4jjb93l	355	13	of	of	IN
cord-334907-l4jjb93l	355	14	3:1	3:1	CD
cord-334907-l4jjb93l	355	15	.	.	.
cord-334907-l4jjb93l	356	1	After	after	IN
cord-334907-l4jjb93l	356	2	vortexing	vortexe	VBG
cord-334907-l4jjb93l	356	3	,	,	,
cord-334907-l4jjb93l	356	4	the	the	DT
cord-334907-l4jjb93l	356	5	mixture	mixture	NN
cord-334907-l4jjb93l	356	6	was	be	VBD
cord-334907-l4jjb93l	356	7	incubated	incubate	VBN
cord-334907-l4jjb93l	356	8	for	for	IN
cord-334907-l4jjb93l	356	9	30	30	CD
cord-334907-l4jjb93l	356	10	min	min	NN
cord-334907-l4jjb93l	356	11	and	and	CC
cord-334907-l4jjb93l	356	12	then	then	RB
cord-334907-l4jjb93l	356	13	added	add	VBD
cord-334907-l4jjb93l	356	14	to	to	IN
cord-334907-l4jjb93l	356	15	the	the	DT
cord-334907-l4jjb93l	356	16	cells	cell	NNS
cord-334907-l4jjb93l	356	17	dropwise	dropwise	RB
cord-334907-l4jjb93l	356	18	.	.	.
cord-334907-l4jjb93l	357	1	After	after	IN
cord-334907-l4jjb93l	357	2	a	a	DT
cord-334907-l4jjb93l	357	3	4	4	CD
cord-334907-l4jjb93l	357	4	h	h	NN
cord-334907-l4jjb93l	357	5	incubation	incubation	NN
cord-334907-l4jjb93l	357	6	at	at	IN
cord-334907-l4jjb93l	357	7	20	20	CD
cord-334907-l4jjb93l	357	8	•	•	NNP
cord-334907-l4jjb93l	357	9	C	C	NNP
cord-334907-l4jjb93l	357	10	,	,	,
cord-334907-l4jjb93l	357	11	the	the	DT
cord-334907-l4jjb93l	357	12	medium	medium	NN
cord-334907-l4jjb93l	357	13	was	be	VBD
cord-334907-l4jjb93l	357	14	removed	remove	VBN
cord-334907-l4jjb93l	357	15	and	and	CC
cord-334907-l4jjb93l	357	16	the	the	DT
cord-334907-l4jjb93l	357	17	cells	cell	NNS
cord-334907-l4jjb93l	357	18	washed	wash	VBD
cord-334907-l4jjb93l	357	19	three	three	CD
cord-334907-l4jjb93l	357	20	times	time	NNS
cord-334907-l4jjb93l	357	21	with	with	IN
cord-334907-l4jjb93l	357	22	L-15	L-15	NNP
cord-334907-l4jjb93l	357	23	medium	medium	NN
cord-334907-l4jjb93l	357	24	.	.	.
cord-334907-l4jjb93l	358	1	Cells	cell	NNS
cord-334907-l4jjb93l	358	2	were	be	VBD
cord-334907-l4jjb93l	358	3	then	then	RB
cord-334907-l4jjb93l	358	4	incubated	incubate	VBN
cord-334907-l4jjb93l	358	5	in	in	IN
cord-334907-l4jjb93l	358	6	supplemented	supplement	VBN
cord-334907-l4jjb93l	358	7	L-15	L-15	NNP
cord-334907-l4jjb93l	358	8	medium	medium	NN
cord-334907-l4jjb93l	358	9	for	for	IN
cord-334907-l4jjb93l	358	10	48	48	CD
cord-334907-l4jjb93l	358	11	h	h	NN
cord-334907-l4jjb93l	358	12	,	,	,
cord-334907-l4jjb93l	358	13	as	as	IN
cord-334907-l4jjb93l	358	14	described	describe	VBN
cord-334907-l4jjb93l	358	15	above	above	RB
cord-334907-l4jjb93l	358	16	,	,	,
cord-334907-l4jjb93l	358	17	to	to	TO
cord-334907-l4jjb93l	358	18	evaluate	evaluate	VB
cord-334907-l4jjb93l	358	19	protein	protein	NN
cord-334907-l4jjb93l	358	20	expression	expression	NN
cord-334907-l4jjb93l	358	21	and	and	CC
cord-334907-l4jjb93l	358	22	perform	perform	VB
cord-334907-l4jjb93l	358	23	functional	functional	JJ
cord-334907-l4jjb93l	358	24	analyses	analysis	NNS
cord-334907-l4jjb93l	358	25	.	.	.
cord-334907-l4jjb93l	359	1	To	to	TO
cord-334907-l4jjb93l	359	2	evaluate	evaluate	VB
cord-334907-l4jjb93l	359	3	the	the	DT
cord-334907-l4jjb93l	359	4	level	level	NN
cord-334907-l4jjb93l	359	5	of	of	IN
cord-334907-l4jjb93l	359	6	expression	expression	NN
cord-334907-l4jjb93l	359	7	of	of	IN
cord-334907-l4jjb93l	359	8	the	the	DT
cord-334907-l4jjb93l	359	9	WT	WT	NNP
cord-334907-l4jjb93l	359	10	and	and	CC
cord-334907-l4jjb93l	359	11	mutant	mutant	NN
cord-334907-l4jjb93l	359	12	HE	HE	NNP
cord-334907-l4jjb93l	359	13	and	and	CC
cord-334907-l4jjb93l	359	14	F	F	NNP
cord-334907-l4jjb93l	359	15	,	,	,
cord-334907-l4jjb93l	359	16	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	359	17	assays	assay	NNS
cord-334907-l4jjb93l	359	18	were	be	VBD
cord-334907-l4jjb93l	359	19	performed	perform	VBN
cord-334907-l4jjb93l	359	20	on	on	IN
cord-334907-l4jjb93l	359	21	transfected	transfecte	VBN
cord-334907-l4jjb93l	359	22	CHSE	CHSE	NNP
cord-334907-l4jjb93l	359	23	/	/	SYM
cord-334907-l4jjb93l	359	24	F	F	NNP
cord-334907-l4jjb93l	359	25	cells	cell	NNS
cord-334907-l4jjb93l	359	26	,	,	,
cord-334907-l4jjb93l	359	27	using	use	VBG
cord-334907-l4jjb93l	359	28	the	the	DT
cord-334907-l4jjb93l	359	29	anti	anti	JJ
cord-334907-l4jjb93l	359	30	-	-	JJ
cord-334907-l4jjb93l	359	31	FLAG	flag	JJ
cord-334907-l4jjb93l	359	32	M2	m2	JJ
cord-334907-l4jjb93l	359	33	antibody	antibody	NN
cord-334907-l4jjb93l	359	34	to	to	TO
cord-334907-l4jjb93l	359	35	detect	detect	VB
cord-334907-l4jjb93l	359	36	the	the	DT
cord-334907-l4jjb93l	359	37	3pFLAG	3pflag	CD
cord-334907-l4jjb93l	359	38	tag	tag	NN
cord-334907-l4jjb93l	359	39	on	on	IN
cord-334907-l4jjb93l	359	40	the	the	DT
cord-334907-l4jjb93l	359	41	3	3	CD
cord-334907-l4jjb93l	359	42	end	end	NN
cord-334907-l4jjb93l	359	43	of	of	IN
cord-334907-l4jjb93l	359	44	each	each	DT
cord-334907-l4jjb93l	359	45	construct	construct	NN
cord-334907-l4jjb93l	359	46	.	.	.
cord-334907-l4jjb93l	360	1	After	after	IN
cord-334907-l4jjb93l	360	2	two	two	CD
cord-334907-l4jjb93l	360	3	PBS	PBS	NNP
cord-334907-l4jjb93l	360	4	washes	wash	NNS
cord-334907-l4jjb93l	360	5	,	,	,
cord-334907-l4jjb93l	360	6	cells	cell	NNS
cord-334907-l4jjb93l	360	7	were	be	VBD
cord-334907-l4jjb93l	360	8	fixed	fix	VBN
cord-334907-l4jjb93l	360	9	with	with	IN
cord-334907-l4jjb93l	360	10	4	4	CD
cord-334907-l4jjb93l	360	11	%	%	NN
cord-334907-l4jjb93l	360	12	paraformaldehyde	paraformaldehyde	NN
cord-334907-l4jjb93l	360	13	and	and	CC
cord-334907-l4jjb93l	360	14	then	then	RB
cord-334907-l4jjb93l	360	15	treated	treat	VBN
cord-334907-l4jjb93l	360	16	with	with	IN
cord-334907-l4jjb93l	360	17	blocking	block	VBG
cord-334907-l4jjb93l	360	18	buffer	buffer	NN
cord-334907-l4jjb93l	360	19	as	as	IN
cord-334907-l4jjb93l	360	20	described	describe	VBN
cord-334907-l4jjb93l	360	21	above	above	RB
cord-334907-l4jjb93l	360	22	.	.	.
cord-334907-l4jjb93l	361	1	Anti	anti	JJ
cord-334907-l4jjb93l	361	2	-	-	NNP
cord-334907-l4jjb93l	361	3	FLAG	flag	JJ
cord-334907-l4jjb93l	361	4	M2	M2	NNP
cord-334907-l4jjb93l	361	5	antibody	antibody	NN
cord-334907-l4jjb93l	361	6	was	be	VBD
cord-334907-l4jjb93l	361	7	added	add	VBN
cord-334907-l4jjb93l	361	8	to	to	IN
cord-334907-l4jjb93l	361	9	the	the	DT
cord-334907-l4jjb93l	361	10	cells	cell	NNS
cord-334907-l4jjb93l	361	11	at	at	IN
cord-334907-l4jjb93l	361	12	a	a	DT
cord-334907-l4jjb93l	361	13	1/100	1/100	CD
cord-334907-l4jjb93l	361	14	dilution	dilution	NN
cord-334907-l4jjb93l	361	15	in	in	IN
cord-334907-l4jjb93l	361	16	blocking	block	VBG
cord-334907-l4jjb93l	361	17	buffer	buffer	NN
cord-334907-l4jjb93l	361	18	.	.	.
cord-334907-l4jjb93l	362	1	After	after	IN
cord-334907-l4jjb93l	362	2	1	1	CD
cord-334907-l4jjb93l	362	3	h	h	NN
cord-334907-l4jjb93l	362	4	incubation	incubation	NN
cord-334907-l4jjb93l	362	5	and	and	CC
cord-334907-l4jjb93l	362	6	three	three	CD
cord-334907-l4jjb93l	362	7	PBS	PBS	NNP
cord-334907-l4jjb93l	362	8	washes	wash	NNS
cord-334907-l4jjb93l	362	9	,	,	,
cord-334907-l4jjb93l	362	10	Alexa	Alexa	NNP
cord-334907-l4jjb93l	362	11	Fluor	Fluor	NNP
cord-334907-l4jjb93l	362	12	568	568	CD
cord-334907-l4jjb93l	362	13	conjugated	conjugate	VBN
cord-334907-l4jjb93l	362	14	goat	goat	NN
cord-334907-l4jjb93l	362	15	anti	anti	NNP
cord-334907-l4jjb93l	362	16	-	-	NN
cord-334907-l4jjb93l	362	17	mouse	mouse	NN
cord-334907-l4jjb93l	362	18	was	be	VBD
cord-334907-l4jjb93l	362	19	added	add	VBN
cord-334907-l4jjb93l	362	20	to	to	IN
cord-334907-l4jjb93l	362	21	the	the	DT
cord-334907-l4jjb93l	362	22	cells	cell	NNS
cord-334907-l4jjb93l	362	23	at	at	IN
cord-334907-l4jjb93l	362	24	a	a	DT
cord-334907-l4jjb93l	362	25	1/200	1/200	CD
cord-334907-l4jjb93l	362	26	dilution	dilution	NN
cord-334907-l4jjb93l	362	27	in	in	IN
cord-334907-l4jjb93l	362	28	blocking	block	VBG
cord-334907-l4jjb93l	362	29	buffer	buffer	NN
cord-334907-l4jjb93l	362	30	.	.	.
cord-334907-l4jjb93l	363	1	After	after	IN
cord-334907-l4jjb93l	363	2	a	a	DT
cord-334907-l4jjb93l	363	3	1	1	CD
cord-334907-l4jjb93l	363	4	h	h	NN
cord-334907-l4jjb93l	363	5	incubation	incubation	NN
cord-334907-l4jjb93l	363	6	,	,	,
cord-334907-l4jjb93l	363	7	cells	cell	NNS
cord-334907-l4jjb93l	363	8	were	be	VBD
cord-334907-l4jjb93l	363	9	washed	wash	VBN
cord-334907-l4jjb93l	363	10	three	three	CD
cord-334907-l4jjb93l	363	11	times	time	NNS
cord-334907-l4jjb93l	363	12	with	with	IN
cord-334907-l4jjb93l	363	13	PBS	PBS	NNP
cord-334907-l4jjb93l	363	14	,	,	,
cord-334907-l4jjb93l	363	15	adding	add	VBG
cord-334907-l4jjb93l	363	16	a	a	DT
cord-334907-l4jjb93l	363	17	final	final	JJ
cord-334907-l4jjb93l	363	18	1	1	CD
cord-334907-l4jjb93l	363	19	mL	ml	NN
cord-334907-l4jjb93l	363	20	of	of	IN
cord-334907-l4jjb93l	363	21	the	the	DT
cord-334907-l4jjb93l	363	22	same	same	JJ
cord-334907-l4jjb93l	363	23	buffer	buffer	NN
cord-334907-l4jjb93l	363	24	,	,	,
cord-334907-l4jjb93l	363	25	and	and	CC
cord-334907-l4jjb93l	363	26	then	then	RB
cord-334907-l4jjb93l	363	27	five	five	CD
cord-334907-l4jjb93l	363	28	representative	representative	JJ
cord-334907-l4jjb93l	363	29	fields	field	NNS
cord-334907-l4jjb93l	363	30	of	of	IN
cord-334907-l4jjb93l	363	31	each	each	DT
cord-334907-l4jjb93l	363	32	transfected	transfecte	VBN
cord-334907-l4jjb93l	363	33	dish	dish	NN
cord-334907-l4jjb93l	363	34	were	be	VBD
cord-334907-l4jjb93l	363	35	analyzed	analyze	VBN
cord-334907-l4jjb93l	363	36	.	.	.
cord-334907-l4jjb93l	364	1	Images	image	NNS
cord-334907-l4jjb93l	364	2	were	be	VBD
cord-334907-l4jjb93l	364	3	captured	capture	VBN
cord-334907-l4jjb93l	364	4	using	use	VBG
cord-334907-l4jjb93l	364	5	the	the	DT
cord-334907-l4jjb93l	364	6	TCSSP5	TCSSP5	NNPS
cord-334907-l4jjb93l	364	7	II	II	NNP
cord-334907-l4jjb93l	364	8	confocal	confocal	JJ
cord-334907-l4jjb93l	364	9	microscope	microscope	NN
cord-334907-l4jjb93l	364	10	and	and	CC
cord-334907-l4jjb93l	364	11	then	then	RB
cord-334907-l4jjb93l	364	12	analyzed	analyze	VBD
cord-334907-l4jjb93l	364	13	using	use	VBG
cord-334907-l4jjb93l	364	14	the	the	DT
cord-334907-l4jjb93l	364	15	Analyze	Analyze	NNP
cord-334907-l4jjb93l	364	16	Tool	Tool	NNP
cord-334907-l4jjb93l	364	17	of	of	IN
cord-334907-l4jjb93l	364	18	the	the	DT
cord-334907-l4jjb93l	364	19	FIJI	FIJI	NNP
cord-334907-l4jjb93l	364	20	software	software	NN
cord-334907-l4jjb93l	364	21	package	package	NN
cord-334907-l4jjb93l	364	22	.	.	.
cord-334907-l4jjb93l	365	1	Corrected	correct	VBN
cord-334907-l4jjb93l	365	2	total	total	JJ
cord-334907-l4jjb93l	365	3	cell	cell	NN
cord-334907-l4jjb93l	365	4	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	365	5	(	(	-LRB-
cord-334907-l4jjb93l	365	6	CTCF	CTCF	NNP
cord-334907-l4jjb93l	365	7	)	)	-RRB-
cord-334907-l4jjb93l	365	8	was	be	VBD
cord-334907-l4jjb93l	365	9	calculated	calculate	VBN
cord-334907-l4jjb93l	365	10	using	use	VBG
cord-334907-l4jjb93l	365	11	CTCF	CTCF	NNP
cord-334907-l4jjb93l	365	12	=	=	SYM
cord-334907-l4jjb93l	365	13	integrated	integrate	VBN
cord-334907-l4jjb93l	365	14	density	density	NN
cord-334907-l4jjb93l	365	15	−	−	NNP
cord-334907-l4jjb93l	365	16	(	(	-LRB-
cord-334907-l4jjb93l	365	17	selected	select	VBN
cord-334907-l4jjb93l	365	18	area	area	NN
cord-334907-l4jjb93l	365	19	×	×	NN
cord-334907-l4jjb93l	365	20	background	background	NN
cord-334907-l4jjb93l	365	21	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	365	22	)	)	-RRB-
cord-334907-l4jjb93l	365	23	and	and	CC
cord-334907-l4jjb93l	365	24	used	use	VBD
cord-334907-l4jjb93l	365	25	as	as	IN
cord-334907-l4jjb93l	365	26	a	a	DT
cord-334907-l4jjb93l	365	27	measure	measure	NN
cord-334907-l4jjb93l	365	28	of	of	IN
cord-334907-l4jjb93l	365	29	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	365	30	intensity	intensity	NN
cord-334907-l4jjb93l	365	31	and	and	CC
cord-334907-l4jjb93l	365	32	protein	protein	NN
cord-334907-l4jjb93l	365	33	expression	expression	NN
cord-334907-l4jjb93l	365	34	level	level	NN
cord-334907-l4jjb93l	365	35	[	[	-LRB-
cord-334907-l4jjb93l	365	36	61	61	CD
cord-334907-l4jjb93l	365	37	]	]	-RRB-
cord-334907-l4jjb93l	365	38	.	.	.
cord-334907-l4jjb93l	366	1	In	in	IN
cord-334907-l4jjb93l	366	2	parallel	parallel	NN
cord-334907-l4jjb93l	366	3	,	,	,
cord-334907-l4jjb93l	366	4	the	the	DT
cord-334907-l4jjb93l	366	5	expression	expression	NN
cord-334907-l4jjb93l	366	6	of	of	IN
cord-334907-l4jjb93l	366	7	the	the	DT
cord-334907-l4jjb93l	366	8	HE	HE	NNP
cord-334907-l4jjb93l	366	9	-	-	HYPH
cord-334907-l4jjb93l	366	10	eGFP	eGFP	NNP
cord-334907-l4jjb93l	366	11	and	and	CC
cord-334907-l4jjb93l	366	12	F	F	NNP
cord-334907-l4jjb93l	366	13	-	-	HYPH
cord-334907-l4jjb93l	366	14	mCherry	mCherry	NNP
cord-334907-l4jjb93l	366	15	fusion	fusion	NN
cord-334907-l4jjb93l	366	16	constructs	construct	NNS
cord-334907-l4jjb93l	366	17	was	be	VBD
cord-334907-l4jjb93l	366	18	evaluated	evaluate	VBN
cord-334907-l4jjb93l	366	19	on	on	IN
cord-334907-l4jjb93l	366	20	the	the	DT
cord-334907-l4jjb93l	366	21	co	co	NN
cord-334907-l4jjb93l	366	22	-	-	JJ
cord-334907-l4jjb93l	366	23	transfected	transfecte	VBN
cord-334907-l4jjb93l	366	24	cells	cell	NNS
cord-334907-l4jjb93l	366	25	to	to	TO
cord-334907-l4jjb93l	366	26	ensure	ensure	VB
cord-334907-l4jjb93l	366	27	the	the	DT
cord-334907-l4jjb93l	366	28	co	co	NN
cord-334907-l4jjb93l	366	29	-	-	NN
cord-334907-l4jjb93l	366	30	expression	expression	NN
cord-334907-l4jjb93l	366	31	of	of	IN
cord-334907-l4jjb93l	366	32	both	both	DT
cord-334907-l4jjb93l	366	33	proteins	protein	NNS
cord-334907-l4jjb93l	366	34	.	.	.
cord-334907-l4jjb93l	367	1	As	as	IN
cord-334907-l4jjb93l	367	2	described	describe	VBN
cord-334907-l4jjb93l	367	3	above	above	RB
cord-334907-l4jjb93l	367	4	,	,	,
cord-334907-l4jjb93l	367	5	five	five	CD
cord-334907-l4jjb93l	367	6	fields	field	NNS
cord-334907-l4jjb93l	367	7	of	of	IN
cord-334907-l4jjb93l	367	8	each	each	DT
cord-334907-l4jjb93l	367	9	transfected	transfecte	VBN
cord-334907-l4jjb93l	367	10	dish	dish	NN
cord-334907-l4jjb93l	367	11	were	be	VBD
cord-334907-l4jjb93l	367	12	evaluated	evaluate	VBN
cord-334907-l4jjb93l	367	13	by	by	IN
cord-334907-l4jjb93l	367	14	direct	direct	JJ
cord-334907-l4jjb93l	367	15	observation	observation	NN
cord-334907-l4jjb93l	367	16	on	on	IN
cord-334907-l4jjb93l	367	17	the	the	DT
cord-334907-l4jjb93l	367	18	confocal	confocal	JJ
cord-334907-l4jjb93l	367	19	microscope	microscope	NN
cord-334907-l4jjb93l	367	20	.	.	.
cord-334907-l4jjb93l	368	1	Blood	blood	NN
cord-334907-l4jjb93l	368	2	samples	sample	NNS
cord-334907-l4jjb93l	368	3	(	(	-LRB-
cord-334907-l4jjb93l	368	4	500	500	CD
cord-334907-l4jjb93l	368	5	µL	µl	CD
cord-334907-l4jjb93l	368	6	)	)	-RRB-
cord-334907-l4jjb93l	368	7	were	be	VBD
cord-334907-l4jjb93l	368	8	obtained	obtain	VBN
cord-334907-l4jjb93l	368	9	from	from	IN
cord-334907-l4jjb93l	368	10	pre	pre	JJ
cord-334907-l4jjb93l	368	11	-	-	JJ
cord-334907-l4jjb93l	368	12	smolt	smolt	JJ
cord-334907-l4jjb93l	368	13	Salmo	Salmo	NNP
cord-334907-l4jjb93l	368	14	salar	salar	NN
cord-334907-l4jjb93l	368	15	(	(	-LRB-
cord-334907-l4jjb93l	368	16	40	40	CD
cord-334907-l4jjb93l	368	17	g	g	NN
cord-334907-l4jjb93l	368	18	)	)	-RRB-
cord-334907-l4jjb93l	368	19	after	after	IN
cord-334907-l4jjb93l	368	20	appropriate	appropriate	JJ
cord-334907-l4jjb93l	368	21	sedation	sedation	NN
cord-334907-l4jjb93l	368	22	in	in	IN
cord-334907-l4jjb93l	368	23	0.001	0.001	CD
cord-334907-l4jjb93l	368	24	%	%	NN
cord-334907-l4jjb93l	368	25	benzocaine	benzocaine	NN
cord-334907-l4jjb93l	368	26	(	(	-LRB-
cord-334907-l4jjb93l	368	27	Centrovet	Centrovet	NNP
cord-334907-l4jjb93l	368	28	,	,	,
cord-334907-l4jjb93l	368	29	Santiago	Santiago	NNP
cord-334907-l4jjb93l	368	30	,	,	,
cord-334907-l4jjb93l	368	31	Chile	Chile	NNP
cord-334907-l4jjb93l	368	32	)	)	-RRB-
cord-334907-l4jjb93l	368	33	for	for	IN
cord-334907-l4jjb93l	368	34	10	10	CD
cord-334907-l4jjb93l	368	35	min	min	NN
cord-334907-l4jjb93l	368	36	.	.	.
cord-334907-l4jjb93l	369	1	Syringes	syrinx	NNS
cord-334907-l4jjb93l	369	2	and	and	CC
cord-334907-l4jjb93l	369	3	collection	collection	NN
cord-334907-l4jjb93l	369	4	tubes	tube	NNS
cord-334907-l4jjb93l	369	5	were	be	VBD
cord-334907-l4jjb93l	369	6	treated	treat	VBN
cord-334907-l4jjb93l	369	7	with	with	IN
cord-334907-l4jjb93l	369	8	an	an	DT
cord-334907-l4jjb93l	369	9	anticoagulant	anticoagulant	JJ
cord-334907-l4jjb93l	369	10	solution	solution	NN
cord-334907-l4jjb93l	369	11	containing	contain	VBG
cord-334907-l4jjb93l	369	12	10	10	CD
cord-334907-l4jjb93l	369	13	mM	mm	CD
cord-334907-l4jjb93l	369	14	sodium	sodium	NN
cord-334907-l4jjb93l	369	15	citrate	citrate	NN
cord-334907-l4jjb93l	369	16	,	,	,
cord-334907-l4jjb93l	369	17	prior	prior	RB
cord-334907-l4jjb93l	369	18	to	to	IN
cord-334907-l4jjb93l	369	19	blood	blood	NN
cord-334907-l4jjb93l	369	20	collection	collection	NN
cord-334907-l4jjb93l	369	21	.	.	.
cord-334907-l4jjb93l	370	1	Purified	purify	VBN
cord-334907-l4jjb93l	370	2	red	red	JJ
cord-334907-l4jjb93l	370	3	blood	blood	NN
cord-334907-l4jjb93l	370	4	cells	cell	NNS
cord-334907-l4jjb93l	370	5	(	(	-LRB-
cord-334907-l4jjb93l	370	6	RBC	RBC	NNP
cord-334907-l4jjb93l	370	7	)	)	-RRB-
cord-334907-l4jjb93l	370	8	were	be	VBD
cord-334907-l4jjb93l	370	9	obtained	obtain	VBN
cord-334907-l4jjb93l	370	10	via	via	IN
cord-334907-l4jjb93l	370	11	sedimentation	sedimentation	NN
cord-334907-l4jjb93l	370	12	of	of	IN
cord-334907-l4jjb93l	370	13	blood	blood	NN
cord-334907-l4jjb93l	370	14	cells	cell	NNS
cord-334907-l4jjb93l	370	15	after	after	IN
cord-334907-l4jjb93l	370	16	centrifugation	centrifugation	NN
cord-334907-l4jjb93l	370	17	at	at	IN
cord-334907-l4jjb93l	370	18	110×	110×	CD
cord-334907-l4jjb93l	370	19	g	g	NN
cord-334907-l4jjb93l	370	20	for	for	IN
cord-334907-l4jjb93l	370	21	10	10	CD
cord-334907-l4jjb93l	370	22	min	min	NN
cord-334907-l4jjb93l	370	23	.	.	.
cord-334907-l4jjb93l	371	1	Cells	cell	NNS
cord-334907-l4jjb93l	371	2	were	be	VBD
cord-334907-l4jjb93l	371	3	washed	wash	VBN
cord-334907-l4jjb93l	371	4	three	three	CD
cord-334907-l4jjb93l	371	5	times	time	NNS
cord-334907-l4jjb93l	371	6	with	with	IN
cord-334907-l4jjb93l	371	7	PBS	PBS	NNP
cord-334907-l4jjb93l	371	8	and	and	CC
cord-334907-l4jjb93l	371	9	finally	finally	RB
cord-334907-l4jjb93l	371	10	re	re	NN
cord-334907-l4jjb93l	371	11	-	-	VBN
cord-334907-l4jjb93l	371	12	suspended	suspend	VBN
cord-334907-l4jjb93l	371	13	in	in	IN
cord-334907-l4jjb93l	371	14	the	the	DT
cord-334907-l4jjb93l	371	15	same	same	JJ
cord-334907-l4jjb93l	371	16	buffer	buffer	NN
cord-334907-l4jjb93l	371	17	to	to	TO
cord-334907-l4jjb93l	371	18	obtain	obtain	VB
cord-334907-l4jjb93l	371	19	a	a	DT
cord-334907-l4jjb93l	371	20	0.5	0.5	CD
cord-334907-l4jjb93l	371	21	%	%	NN
cord-334907-l4jjb93l	371	22	RBC	RBC	NNP
cord-334907-l4jjb93l	371	23	suspension	suspension	NN
cord-334907-l4jjb93l	371	24	.	.	.
cord-334907-l4jjb93l	372	1	For	for	IN
cord-334907-l4jjb93l	372	2	the	the	DT
cord-334907-l4jjb93l	372	3	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	372	4	assays	assay	NNS
cord-334907-l4jjb93l	372	5	,	,	,
cord-334907-l4jjb93l	372	6	1	1	CD
cord-334907-l4jjb93l	372	7	mL	ml	NN
cord-334907-l4jjb93l	372	8	of	of	IN
cord-334907-l4jjb93l	372	9	a	a	DT
cord-334907-l4jjb93l	372	10	0.05	0.05	CD
cord-334907-l4jjb93l	372	11	%	%	NN
cord-334907-l4jjb93l	372	12	RBC	RBC	NNP
cord-334907-l4jjb93l	372	13	suspension	suspension	NN
cord-334907-l4jjb93l	372	14	in	in	IN
cord-334907-l4jjb93l	372	15	PBS	PBS	NNP
cord-334907-l4jjb93l	372	16	was	be	VBD
cord-334907-l4jjb93l	372	17	added	add	VBN
cord-334907-l4jjb93l	372	18	to	to	IN
cord-334907-l4jjb93l	372	19	CHSE	CHSE	NNP
cord-334907-l4jjb93l	372	20	/	/	SYM
cord-334907-l4jjb93l	372	21	F	F	NNP
cord-334907-l4jjb93l	372	22	cells	cell	NNS
cord-334907-l4jjb93l	372	23	expressing	express	VBG
cord-334907-l4jjb93l	372	24	WT	WT	NNP
cord-334907-l4jjb93l	372	25	HE	HE	NNP
cord-334907-l4jjb93l	372	26	or	or	CC
cord-334907-l4jjb93l	372	27	their	-PRON-	PRP$
cord-334907-l4jjb93l	372	28	mutants	mutant	NNS
cord-334907-l4jjb93l	372	29	.	.	.
cord-334907-l4jjb93l	373	1	Cells	cell	NNS
cord-334907-l4jjb93l	373	2	were	be	VBD
cord-334907-l4jjb93l	373	3	incubated	incubate	VBN
cord-334907-l4jjb93l	373	4	for	for	IN
cord-334907-l4jjb93l	373	5	1	1	CD
cord-334907-l4jjb93l	373	6	h	h	NN
cord-334907-l4jjb93l	373	7	and	and	CC
cord-334907-l4jjb93l	373	8	then	then	RB
cord-334907-l4jjb93l	373	9	washed	wash	VBD
cord-334907-l4jjb93l	373	10	six	six	CD
cord-334907-l4jjb93l	373	11	times	time	NNS
cord-334907-l4jjb93l	373	12	with	with	IN
cord-334907-l4jjb93l	373	13	L-15	L-15	NNP
cord-334907-l4jjb93l	373	14	medium	medium	NN
cord-334907-l4jjb93l	373	15	to	to	TO
cord-334907-l4jjb93l	373	16	remove	remove	VB
cord-334907-l4jjb93l	373	17	unbound	unbound	JJ
cord-334907-l4jjb93l	373	18	cells	cell	NNS
cord-334907-l4jjb93l	373	19	.	.	.
cord-334907-l4jjb93l	374	1	Bound	bind	VBN
cord-334907-l4jjb93l	374	2	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	374	3	were	be	VBD
cord-334907-l4jjb93l	374	4	permeabilized	permeabilize	VBN
cord-334907-l4jjb93l	374	5	by	by	IN
cord-334907-l4jjb93l	374	6	adding	add	VBG
cord-334907-l4jjb93l	374	7	a	a	DT
cord-334907-l4jjb93l	374	8	solution	solution	NN
cord-334907-l4jjb93l	374	9	of	of	IN
cord-334907-l4jjb93l	374	10	0.05	0.05	CD
cord-334907-l4jjb93l	374	11	M	M	NNP
cord-334907-l4jjb93l	374	12	NH	NH	NNP
cord-334907-l4jjb93l	374	13	4	4	CD
cord-334907-l4jjb93l	374	14	Cl	Cl	NNP
cord-334907-l4jjb93l	374	15	,	,	,
cord-334907-l4jjb93l	374	16	followed	follow	VBN
cord-334907-l4jjb93l	374	17	by	by	IN
cord-334907-l4jjb93l	374	18	incubation	incubation	NN
cord-334907-l4jjb93l	374	19	for	for	IN
cord-334907-l4jjb93l	374	20	1	1	CD
cord-334907-l4jjb93l	374	21	h	h	NN
cord-334907-l4jjb93l	374	22	;	;	:
cord-334907-l4jjb93l	374	23	the	the	DT
cord-334907-l4jjb93l	374	24	hemoglobin	hemoglobin	NN
cord-334907-l4jjb93l	374	25	-	-	HYPH
cord-334907-l4jjb93l	374	26	containing	contain	VBG
cord-334907-l4jjb93l	374	27	supernatant	supernatant	NN
cord-334907-l4jjb93l	374	28	was	be	VBD
cord-334907-l4jjb93l	374	29	then	then	RB
cord-334907-l4jjb93l	374	30	transferred	transfer	VBN
cord-334907-l4jjb93l	374	31	to	to	IN
cord-334907-l4jjb93l	374	32	a	a	DT
cord-334907-l4jjb93l	374	33	96-well	96-well	CD
cord-334907-l4jjb93l	374	34	plate	plate	NN
cord-334907-l4jjb93l	374	35	for	for	IN
cord-334907-l4jjb93l	374	36	absorbance	absorbance	NN
cord-334907-l4jjb93l	374	37	reading	reading	NN
cord-334907-l4jjb93l	374	38	at	at	IN
cord-334907-l4jjb93l	374	39	540	540	CD
cord-334907-l4jjb93l	374	40	nm	nm	NN
cord-334907-l4jjb93l	374	41	to	to	TO
cord-334907-l4jjb93l	374	42	measure	measure	VB
cord-334907-l4jjb93l	374	43	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	374	44	[	[	-LRB-
cord-334907-l4jjb93l	374	45	18	18	CD
cord-334907-l4jjb93l	374	46	]	]	-RRB-
cord-334907-l4jjb93l	374	47	.	.	.
cord-334907-l4jjb93l	375	1	For	for	IN
cord-334907-l4jjb93l	375	2	the	the	DT
cord-334907-l4jjb93l	375	3	membrane	membrane	NN
cord-334907-l4jjb93l	375	4	fusion	fusion	NN
cord-334907-l4jjb93l	375	5	assays	assay	NNS
cord-334907-l4jjb93l	375	6	,	,	,
cord-334907-l4jjb93l	375	7	RBCs	rbc	NNS
cord-334907-l4jjb93l	375	8	membranes	membrane	NNS
cord-334907-l4jjb93l	375	9	were	be	VBD
cord-334907-l4jjb93l	375	10	fluorescently	fluorescently	RB
cord-334907-l4jjb93l	375	11	labeled	label	VBN
cord-334907-l4jjb93l	375	12	with	with	IN
cord-334907-l4jjb93l	375	13	octadecyl	octadecyl	JJ
cord-334907-l4jjb93l	375	14	rhodamine	rhodamine	NN
cord-334907-l4jjb93l	375	15	B	B	NNP
cord-334907-l4jjb93l	375	16	chloride	chloride	NN
cord-334907-l4jjb93l	375	17	(	(	-LRB-
cord-334907-l4jjb93l	375	18	R18	R18	NNP
cord-334907-l4jjb93l	375	19	)	)	-RRB-
cord-334907-l4jjb93l	376	1	(	(	-LRB-
cord-334907-l4jjb93l	376	2	Molecular	Molecular	NNP
cord-334907-l4jjb93l	376	3	Probes	Probes	NNPS
cord-334907-l4jjb93l	376	4	,	,	,
cord-334907-l4jjb93l	376	5	Eugene	Eugene	NNP
cord-334907-l4jjb93l	376	6	,	,	,
cord-334907-l4jjb93l	376	7	Oregon	Oregon	NNP
cord-334907-l4jjb93l	376	8	,	,	,
cord-334907-l4jjb93l	376	9	USA	USA	NNP
cord-334907-l4jjb93l	376	10	)	)	-RRB-
cord-334907-l4jjb93l	376	11	.	.	.
cord-334907-l4jjb93l	377	1	Briefly	briefly	RB
cord-334907-l4jjb93l	377	2	,	,	,
cord-334907-l4jjb93l	377	3	15	15	CD
cord-334907-l4jjb93l	377	4	µL	µl	CD
cord-334907-l4jjb93l	377	5	of	of	IN
cord-334907-l4jjb93l	377	6	a	a	DT
cord-334907-l4jjb93l	377	7	1	1	CD
cord-334907-l4jjb93l	377	8	mg	mg	NNP
cord-334907-l4jjb93l	377	9	/	/	SYM
cord-334907-l4jjb93l	377	10	mL	mL	NNP
cord-334907-l4jjb93l	377	11	R18	r18	NN
cord-334907-l4jjb93l	377	12	solution	solution	NN
cord-334907-l4jjb93l	377	13	was	be	VBD
cord-334907-l4jjb93l	377	14	quickly	quickly	RB
cord-334907-l4jjb93l	377	15	added	add	VBN
cord-334907-l4jjb93l	377	16	to	to	IN
cord-334907-l4jjb93l	377	17	10	10	CD
cord-334907-l4jjb93l	377	18	mL	mL	NNS
cord-334907-l4jjb93l	377	19	of	of	IN
cord-334907-l4jjb93l	377	20	a	a	DT
cord-334907-l4jjb93l	377	21	1	1	CD
cord-334907-l4jjb93l	377	22	%	%	NN
cord-334907-l4jjb93l	377	23	RBC	RBC	NNP
cord-334907-l4jjb93l	377	24	suspension	suspension	NN
cord-334907-l4jjb93l	377	25	in	in	IN
cord-334907-l4jjb93l	377	26	PBS	PBS	NNP
cord-334907-l4jjb93l	377	27	.	.	.
cord-334907-l4jjb93l	378	1	The	the	DT
cord-334907-l4jjb93l	378	2	mix	mix	NN
cord-334907-l4jjb93l	378	3	was	be	VBD
cord-334907-l4jjb93l	378	4	incubated	incubate	VBN
cord-334907-l4jjb93l	378	5	for	for	IN
cord-334907-l4jjb93l	378	6	15	15	CD
cord-334907-l4jjb93l	378	7	min	min	NN
cord-334907-l4jjb93l	378	8	at	at	IN
cord-334907-l4jjb93l	378	9	120	120	CD
cord-334907-l4jjb93l	378	10	rpm	rpm	NN
cord-334907-l4jjb93l	378	11	agitation	agitation	NN
cord-334907-l4jjb93l	378	12	.	.	.
cord-334907-l4jjb93l	379	1	Then	then	RB
cord-334907-l4jjb93l	379	2	,	,	,
cord-334907-l4jjb93l	379	3	30	30	CD
cord-334907-l4jjb93l	379	4	mL	ml	NN
cord-334907-l4jjb93l	379	5	of	of	IN
cord-334907-l4jjb93l	379	6	supplemented	supplement	VBN
cord-334907-l4jjb93l	379	7	L-15	L-15	NNP
cord-334907-l4jjb93l	379	8	medium	medium	NN
cord-334907-l4jjb93l	379	9	was	be	VBD
cord-334907-l4jjb93l	379	10	added	add	VBN
cord-334907-l4jjb93l	379	11	,	,	,
cord-334907-l4jjb93l	379	12	incubating	incubate	VBG
cord-334907-l4jjb93l	379	13	for	for	IN
cord-334907-l4jjb93l	379	14	an	an	DT
cord-334907-l4jjb93l	379	15	additional	additional	JJ
cord-334907-l4jjb93l	379	16	20	20	CD
cord-334907-l4jjb93l	379	17	min	min	NN
cord-334907-l4jjb93l	379	18	.	.	.
cord-334907-l4jjb93l	380	1	Erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	380	2	were	be	VBD
cord-334907-l4jjb93l	380	3	sedimented	sediment	VBN
cord-334907-l4jjb93l	380	4	by	by	IN
cord-334907-l4jjb93l	380	5	centrifugation	centrifugation	NN
cord-334907-l4jjb93l	380	6	at	at	IN
cord-334907-l4jjb93l	380	7	110×	110×	CD
cord-334907-l4jjb93l	380	8	g	g	NN
cord-334907-l4jjb93l	380	9	and	and	CC
cord-334907-l4jjb93l	380	10	washed	wash	VBD
cord-334907-l4jjb93l	380	11	six	six	CD
cord-334907-l4jjb93l	380	12	times	time	NNS
cord-334907-l4jjb93l	380	13	with	with	IN
cord-334907-l4jjb93l	380	14	50	50	CD
cord-334907-l4jjb93l	380	15	mL	mL	NNS
cord-334907-l4jjb93l	380	16	of	of	IN
cord-334907-l4jjb93l	380	17	PBS	PBS	NNP
cord-334907-l4jjb93l	380	18	to	to	TO
cord-334907-l4jjb93l	380	19	remove	remove	VB
cord-334907-l4jjb93l	380	20	the	the	DT
cord-334907-l4jjb93l	380	21	excess	excess	NN
cord-334907-l4jjb93l	380	22	of	of	IN
cord-334907-l4jjb93l	380	23	dye	dye	NN
cord-334907-l4jjb93l	380	24	.	.	.
cord-334907-l4jjb93l	381	1	RBCs	rbc	NNS
cord-334907-l4jjb93l	381	2	were	be	VBD
cord-334907-l4jjb93l	381	3	re	re	VBN
cord-334907-l4jjb93l	381	4	-	-	VBN
cord-334907-l4jjb93l	381	5	suspended	suspend	VBN
cord-334907-l4jjb93l	381	6	in	in	IN
cord-334907-l4jjb93l	381	7	PBS	PBS	NNP
cord-334907-l4jjb93l	381	8	to	to	TO
cord-334907-l4jjb93l	381	9	obtain	obtain	VB
cord-334907-l4jjb93l	381	10	a	a	DT
cord-334907-l4jjb93l	381	11	0.1	0.1	CD
cord-334907-l4jjb93l	381	12	%	%	NN
cord-334907-l4jjb93l	381	13	suspension	suspension	NN
cord-334907-l4jjb93l	381	14	[	[	-LRB-
cord-334907-l4jjb93l	381	15	62	62	CD
cord-334907-l4jjb93l	381	16	]	]	-RRB-
cord-334907-l4jjb93l	381	17	.	.	.
cord-334907-l4jjb93l	382	1	To	to	TO
cord-334907-l4jjb93l	382	2	evaluate	evaluate	VB
cord-334907-l4jjb93l	382	3	the	the	DT
cord-334907-l4jjb93l	382	4	fusion	fusion	NN
cord-334907-l4jjb93l	382	5	activity	activity	NN
cord-334907-l4jjb93l	382	6	of	of	IN
cord-334907-l4jjb93l	382	7	the	the	DT
cord-334907-l4jjb93l	382	8	different	different	JJ
cord-334907-l4jjb93l	382	9	combinations	combination	NNS
cord-334907-l4jjb93l	382	10	of	of	IN
cord-334907-l4jjb93l	382	11	ISAV	ISAV	NNP
cord-334907-l4jjb93l	382	12	surface	surface	NN
cord-334907-l4jjb93l	382	13	proteins	protein	NNS
cord-334907-l4jjb93l	382	14	,	,	,
cord-334907-l4jjb93l	382	15	CHSE	CHSE	NNP
cord-334907-l4jjb93l	382	16	/	/	SYM
cord-334907-l4jjb93l	382	17	F	F	NNP
cord-334907-l4jjb93l	382	18	cells	cell	NNS
cord-334907-l4jjb93l	382	19	expressing	express	VBG
cord-334907-l4jjb93l	382	20	WT	WT	NNP
cord-334907-l4jjb93l	382	21	or	or	CC
cord-334907-l4jjb93l	382	22	mutant	mutant	JJ
cord-334907-l4jjb93l	382	23	HE	HE	NNP
cord-334907-l4jjb93l	382	24	and	and	CC
cord-334907-l4jjb93l	382	25	F	F	NNP
cord-334907-l4jjb93l	382	26	were	be	VBD
cord-334907-l4jjb93l	382	27	washed	wash	VBN
cord-334907-l4jjb93l	382	28	two	two	CD
cord-334907-l4jjb93l	382	29	times	time	NNS
cord-334907-l4jjb93l	382	30	with	with	IN
cord-334907-l4jjb93l	382	31	L-15	L-15	NNP
cord-334907-l4jjb93l	382	32	medium	medium	NN
cord-334907-l4jjb93l	382	33	and	and	CC
cord-334907-l4jjb93l	382	34	then	then	RB
cord-334907-l4jjb93l	382	35	incubated	incubate	VBN
cord-334907-l4jjb93l	382	36	with	with	IN
cord-334907-l4jjb93l	382	37	20	20	CD
cord-334907-l4jjb93l	382	38	µg	µg	NN
cord-334907-l4jjb93l	382	39	/	/	SYM
cord-334907-l4jjb93l	382	40	mL	ml	NN
cord-334907-l4jjb93l	382	41	trypsin	trypsin	NN
cord-334907-l4jjb93l	382	42	for	for	IN
cord-334907-l4jjb93l	382	43	15	15	CD
cord-334907-l4jjb93l	382	44	min	min	NN
cord-334907-l4jjb93l	382	45	.	.	.
cord-334907-l4jjb93l	383	1	The	the	DT
cord-334907-l4jjb93l	383	2	enzyme	enzyme	NN
cord-334907-l4jjb93l	383	3	was	be	VBD
cord-334907-l4jjb93l	383	4	then	then	RB
cord-334907-l4jjb93l	383	5	inactivated	inactivate	VBN
cord-334907-l4jjb93l	383	6	by	by	IN
cord-334907-l4jjb93l	383	7	10	10	CD
cord-334907-l4jjb93l	383	8	min	min	NN
cord-334907-l4jjb93l	383	9	incubation	incubation	NN
cord-334907-l4jjb93l	383	10	with	with	IN
cord-334907-l4jjb93l	383	11	supplemented	supplement	VBN
cord-334907-l4jjb93l	383	12	L-15	L-15	NNP
cord-334907-l4jjb93l	383	13	medium	medium	NN
cord-334907-l4jjb93l	383	14	.	.	.
cord-334907-l4jjb93l	384	1	Cells	cell	NNS
cord-334907-l4jjb93l	384	2	were	be	VBD
cord-334907-l4jjb93l	384	3	washed	wash	VBN
cord-334907-l4jjb93l	384	4	three	three	CD
cord-334907-l4jjb93l	384	5	times	time	NNS
cord-334907-l4jjb93l	384	6	with	with	IN
cord-334907-l4jjb93l	384	7	L-15	L-15	NNP
cord-334907-l4jjb93l	384	8	,	,	,
cord-334907-l4jjb93l	384	9	and	and	CC
cord-334907-l4jjb93l	384	10	then	then	RB
cord-334907-l4jjb93l	384	11	1	1	CD
cord-334907-l4jjb93l	384	12	mL	ml	NN
cord-334907-l4jjb93l	384	13	of	of	IN
cord-334907-l4jjb93l	384	14	the	the	DT
cord-334907-l4jjb93l	384	15	R18-labeled	r18-labeled	JJ
cord-334907-l4jjb93l	384	16	RBCs	rbc	NNS
cord-334907-l4jjb93l	384	17	was	be	VBD
cord-334907-l4jjb93l	384	18	added	add	VBN
cord-334907-l4jjb93l	384	19	.	.	.
cord-334907-l4jjb93l	385	1	After	after	IN
cord-334907-l4jjb93l	385	2	15	15	CD
cord-334907-l4jjb93l	385	3	min	min	NN
cord-334907-l4jjb93l	385	4	,	,	,
cord-334907-l4jjb93l	385	5	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	385	6	were	be	VBD
cord-334907-l4jjb93l	385	7	removed	remove	VBN
cord-334907-l4jjb93l	385	8	,	,	,
cord-334907-l4jjb93l	385	9	and	and	CC
cord-334907-l4jjb93l	385	10	the	the	DT
cord-334907-l4jjb93l	385	11	cells	cell	NNS
cord-334907-l4jjb93l	385	12	washed	wash	VBD
cord-334907-l4jjb93l	385	13	six	six	CD
cord-334907-l4jjb93l	385	14	times	time	NNS
cord-334907-l4jjb93l	385	15	with	with	IN
cord-334907-l4jjb93l	385	16	L-15	L-15	NNP
cord-334907-l4jjb93l	385	17	medium	medium	NN
cord-334907-l4jjb93l	385	18	.	.	.
cord-334907-l4jjb93l	386	1	The	the	DT
cord-334907-l4jjb93l	386	2	fusion	fusion	NN
cord-334907-l4jjb93l	386	3	mechanism	mechanism	NN
cord-334907-l4jjb93l	386	4	was	be	VBD
cord-334907-l4jjb93l	386	5	activated	activate	VBN
cord-334907-l4jjb93l	386	6	by	by	IN
cord-334907-l4jjb93l	386	7	adding	add	VBG
cord-334907-l4jjb93l	386	8	1	1	CD
cord-334907-l4jjb93l	386	9	mL	ml	NN
cord-334907-l4jjb93l	386	10	of	of	IN
cord-334907-l4jjb93l	386	11	pH	pH	NNP
cord-334907-l4jjb93l	386	12	4.5	4.5	CD
cord-334907-l4jjb93l	386	13	adjusted	adjust	VBN
cord-334907-l4jjb93l	386	14	L-15	L-15	NNP
cord-334907-l4jjb93l	386	15	medium	medium	NN
cord-334907-l4jjb93l	386	16	and	and	CC
cord-334907-l4jjb93l	386	17	incubating	incubate	VBG
cord-334907-l4jjb93l	386	18	for	for	IN
cord-334907-l4jjb93l	386	19	30	30	CD
cord-334907-l4jjb93l	386	20	min	min	NN
cord-334907-l4jjb93l	386	21	.	.	.
cord-334907-l4jjb93l	387	1	The	the	DT
cord-334907-l4jjb93l	387	2	acid	acid	NN
cord-334907-l4jjb93l	387	3	medium	medium	NN
cord-334907-l4jjb93l	387	4	was	be	VBD
cord-334907-l4jjb93l	387	5	removed	remove	VBN
cord-334907-l4jjb93l	387	6	and	and	CC
cord-334907-l4jjb93l	387	7	cells	cell	NNS
cord-334907-l4jjb93l	387	8	were	be	VBD
cord-334907-l4jjb93l	387	9	fixed	fix	VBN
cord-334907-l4jjb93l	387	10	with	with	IN
cord-334907-l4jjb93l	387	11	4	4	CD
cord-334907-l4jjb93l	387	12	%	%	NN
cord-334907-l4jjb93l	387	13	paraformaldehyde	paraformaldehyde	NNP
cord-334907-l4jjb93l	387	14	,	,	,
cord-334907-l4jjb93l	387	15	as	as	IN
cord-334907-l4jjb93l	387	16	described	describe	VBN
cord-334907-l4jjb93l	387	17	above	above	RB
cord-334907-l4jjb93l	387	18	,	,	,
cord-334907-l4jjb93l	387	19	after	after	IN
cord-334907-l4jjb93l	387	20	three	three	CD
cord-334907-l4jjb93l	387	21	washes	wash	NNS
cord-334907-l4jjb93l	387	22	with	with	IN
cord-334907-l4jjb93l	387	23	L-15	L-15	NNP
cord-334907-l4jjb93l	387	24	medium	medium	NN
cord-334907-l4jjb93l	387	25	.	.	.
cord-334907-l4jjb93l	388	1	Cells	cell	NNS
cord-334907-l4jjb93l	388	2	were	be	VBD
cord-334907-l4jjb93l	388	3	then	then	RB
cord-334907-l4jjb93l	388	4	analyzed	analyze	VBN
cord-334907-l4jjb93l	388	5	using	use	VBG
cord-334907-l4jjb93l	388	6	the	the	DT
cord-334907-l4jjb93l	388	7	confocal	confocal	JJ
cord-334907-l4jjb93l	388	8	microscope	microscope	NN
cord-334907-l4jjb93l	388	9	,	,	,
cord-334907-l4jjb93l	388	10	measuring	measure	VBG
cord-334907-l4jjb93l	388	11	the	the	DT
cord-334907-l4jjb93l	388	12	fusion	fusion	NN
cord-334907-l4jjb93l	388	13	activity	activity	NN
cord-334907-l4jjb93l	388	14	as	as	IN
cord-334907-l4jjb93l	388	15	the	the	DT
cord-334907-l4jjb93l	388	16	percentage	percentage	NN
cord-334907-l4jjb93l	388	17	of	of	IN
cord-334907-l4jjb93l	388	18	membrane	membrane	NN
cord-334907-l4jjb93l	388	19	-	-	HYPH
cord-334907-l4jjb93l	388	20	fused	fuse	VBN
cord-334907-l4jjb93l	388	21	cells	cell	NNS
cord-334907-l4jjb93l	388	22	(	(	-LRB-
cord-334907-l4jjb93l	388	23	i.e.	i.e.	FW
cord-334907-l4jjb93l	388	24	,	,	,
cord-334907-l4jjb93l	388	25	where	where	WRB
cord-334907-l4jjb93l	388	26	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	388	27	was	be	VBD
cord-334907-l4jjb93l	388	28	transferred	transfer	VBN
cord-334907-l4jjb93l	388	29	from	from	IN
cord-334907-l4jjb93l	388	30	the	the	DT
cord-334907-l4jjb93l	388	31	bound	bind	VBN
cord-334907-l4jjb93l	388	32	RBC	RBC	NNP
cord-334907-l4jjb93l	388	33	to	to	IN
cord-334907-l4jjb93l	388	34	the	the	DT
cord-334907-l4jjb93l	388	35	CHSE	CHSE	NNP
cord-334907-l4jjb93l	388	36	/	/	SYM
cord-334907-l4jjb93l	388	37	F	F	NNP
cord-334907-l4jjb93l	388	38	cell	cell	NN
cord-334907-l4jjb93l	388	39	)	)	-RRB-
cord-334907-l4jjb93l	388	40	relative	relative	JJ
cord-334907-l4jjb93l	388	41	to	to	IN
cord-334907-l4jjb93l	388	42	the	the	DT
cord-334907-l4jjb93l	388	43	total	total	JJ
cord-334907-l4jjb93l	388	44	number	number	NN
cord-334907-l4jjb93l	388	45	of	of	IN
cord-334907-l4jjb93l	388	46	CHSE	CHSE	NNP
cord-334907-l4jjb93l	388	47	/	/	SYM
cord-334907-l4jjb93l	388	48	F	F	NNP
cord-334907-l4jjb93l	388	49	cells	cell	NNS
cord-334907-l4jjb93l	388	50	with	with	IN
cord-334907-l4jjb93l	388	51	bound	bind	VBN
cord-334907-l4jjb93l	388	52	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	388	53	.	.	.
cord-334907-l4jjb93l	389	1	Ten	ten	CD
cord-334907-l4jjb93l	389	2	fields	field	NNS
cord-334907-l4jjb93l	389	3	of	of	IN
cord-334907-l4jjb93l	389	4	each	each	DT
cord-334907-l4jjb93l	389	5	dish	dish	NN
cord-334907-l4jjb93l	389	6	,	,	,
cord-334907-l4jjb93l	389	7	with	with	IN
cord-334907-l4jjb93l	389	8	comparable	comparable	JJ
cord-334907-l4jjb93l	389	9	levels	level	NNS
cord-334907-l4jjb93l	389	10	of	of	IN
cord-334907-l4jjb93l	389	11	bound	bind	VBN
cord-334907-l4jjb93l	389	12	RBCs	rbc	NNS
cord-334907-l4jjb93l	389	13	,	,	,
cord-334907-l4jjb93l	389	14	were	be	VBD
cord-334907-l4jjb93l	389	15	analyzed	analyze	VBN
cord-334907-l4jjb93l	389	16	[	[	-LRB-
cord-334907-l4jjb93l	389	17	63	63	CD
cord-334907-l4jjb93l	389	18	]	]	-RRB-
cord-334907-l4jjb93l	389	19	.	.	.
cord-334907-l4jjb93l	390	1	The	the	DT
cord-334907-l4jjb93l	390	2	results	result	NNS
cord-334907-l4jjb93l	390	3	are	be	VBP
cord-334907-l4jjb93l	390	4	presented	present	VBN
cord-334907-l4jjb93l	390	5	as	as	IN
cord-334907-l4jjb93l	390	6	the	the	DT
cord-334907-l4jjb93l	390	7	means	means	NN
cord-334907-l4jjb93l	390	8	±	±	NNP
cord-334907-l4jjb93l	390	9	standard	standard	JJ
cord-334907-l4jjb93l	390	10	deviations	deviation	NNS
cord-334907-l4jjb93l	390	11	of	of	IN
cord-334907-l4jjb93l	390	12	triplicate	triplicate	JJ
cord-334907-l4jjb93l	390	13	determinations	determination	NNS
cord-334907-l4jjb93l	390	14	.	.	.
cord-334907-l4jjb93l	391	1	Statistical	statistical	JJ
cord-334907-l4jjb93l	391	2	significance	significance	NN
cord-334907-l4jjb93l	391	3	of	of	IN
cord-334907-l4jjb93l	391	4	the	the	DT
cord-334907-l4jjb93l	391	5	data	datum	NNS
cord-334907-l4jjb93l	391	6	was	be	VBD
cord-334907-l4jjb93l	391	7	determined	determine	VBN
cord-334907-l4jjb93l	391	8	by	by	IN
cord-334907-l4jjb93l	391	9	using	use	VBG
cord-334907-l4jjb93l	391	10	a	a	DT
cord-334907-l4jjb93l	391	11	Student	Student	NNP
cord-334907-l4jjb93l	391	12	's	's	POS
cord-334907-l4jjb93l	391	13	t	t	NN
cord-334907-l4jjb93l	391	14	-	-	HYPH
cord-334907-l4jjb93l	391	15	test	test	NN
cord-334907-l4jjb93l	391	16	.	.	.
cord-334907-l4jjb93l	392	1	In	in	IN
cord-334907-l4jjb93l	392	2	all	all	DT
cord-334907-l4jjb93l	392	3	figures	figure	NNS
cord-334907-l4jjb93l	392	4	,	,	,
cord-334907-l4jjb93l	392	5	p	p	NN
cord-334907-l4jjb93l	392	6	-	-	HYPH
cord-334907-l4jjb93l	392	7	values	value	NNS
cord-334907-l4jjb93l	392	8	<	<	XX
cord-334907-l4jjb93l	392	9	0.05	0.05	CD
cord-334907-l4jjb93l	392	10	,	,	,
cord-334907-l4jjb93l	392	11	<	<	NNP
cord-334907-l4jjb93l	392	12	0.01	0.01	CD
cord-334907-l4jjb93l	392	13	and	and	CC
cord-334907-l4jjb93l	392	14	<	<	XX
cord-334907-l4jjb93l	392	15	0.001	0.001	CD
cord-334907-l4jjb93l	392	16	are	be	VBP
cord-334907-l4jjb93l	392	17	indicated	indicate	VBN
cord-334907-l4jjb93l	392	18	by	by	IN
cord-334907-l4jjb93l	393	1	*	*	NFP
cord-334907-l4jjb93l	393	2	,	,	,
cord-334907-l4jjb93l	393	3	*	*	NFP
cord-334907-l4jjb93l	393	4	*	*	NFP
cord-334907-l4jjb93l	393	5	and	and	CC
cord-334907-l4jjb93l	394	1	*	*	NFP
cord-334907-l4jjb93l	394	2	*	*	NFP
cord-334907-l4jjb93l	394	3	*	*	NFP
cord-334907-l4jjb93l	394	4	,	,	,
cord-334907-l4jjb93l	394	5	respectively	respectively	RB
cord-334907-l4jjb93l	394	6	,	,	,
cord-334907-l4jjb93l	394	7	and	and	CC
cord-334907-l4jjb93l	394	8	were	be	VBD
cord-334907-l4jjb93l	394	9	considered	consider	VBN
cord-334907-l4jjb93l	394	10	significant	significant	JJ
cord-334907-l4jjb93l	394	11	as	as	IN
cord-334907-l4jjb93l	394	12	properly	properly	RB
cord-334907-l4jjb93l	394	13	indicated	indicate	VBN
cord-334907-l4jjb93l	394	14	.	.	.
cord-334907-l4jjb93l	395	1	Supplementary	supplementary	JJ
cord-334907-l4jjb93l	395	2	Materials	material	NNS
cord-334907-l4jjb93l	395	3	:	:	:
cord-334907-l4jjb93l	395	4	The	the	DT
cord-334907-l4jjb93l	395	5	following	follow	VBG
cord-334907-l4jjb93l	395	6	are	be	VBP
cord-334907-l4jjb93l	395	7	available	available	JJ
cord-334907-l4jjb93l	395	8	online	online	RB
cord-334907-l4jjb93l	395	9	at	at	IN
cord-334907-l4jjb93l	395	10	http://www.mdpi.com/2076-0817/9/6/416/s1	http://www.mdpi.com/2076-0817/9/6/416/s1	NNP
cord-334907-l4jjb93l	395	11	,	,	,
cord-334907-l4jjb93l	395	12	Figure	figure	NN
cord-334907-l4jjb93l	395	13	S1	s1	NN
cord-334907-l4jjb93l	395	14	:	:	:
cord-334907-l4jjb93l	395	15	Immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	395	16	assays	assay	NNS
cord-334907-l4jjb93l	395	17	and	and	CC
cord-334907-l4jjb93l	395	18	heterologous	heterologous	JJ
cord-334907-l4jjb93l	395	19	protein	protein	NN
cord-334907-l4jjb93l	395	20	expression	expression	NN
cord-334907-l4jjb93l	395	21	levels	level	NNS
cord-334907-l4jjb93l	395	22	in	in	IN
cord-334907-l4jjb93l	395	23	CHSE	CHSE	NNP
cord-334907-l4jjb93l	395	24	/	/	SYM
cord-334907-l4jjb93l	395	25	F	F	NNP
cord-334907-l4jjb93l	395	26	cells	cell	NNS
cord-334907-l4jjb93l	395	27	.	.	.
cord-334907-l4jjb93l	396	1	Transfected	transfected	JJ
cord-334907-l4jjb93l	396	2	cells	cell	NNS
cord-334907-l4jjb93l	396	3	were	be	VBD
cord-334907-l4jjb93l	396	4	evaluated	evaluate	VBN
cord-334907-l4jjb93l	396	5	48	48	CD
cord-334907-l4jjb93l	396	6	h	h	NN
cord-334907-l4jjb93l	396	7	post	post	NN
cord-334907-l4jjb93l	396	8	-	-	NN
cord-334907-l4jjb93l	396	9	transfection	transfection	NN
cord-334907-l4jjb93l	396	10	via	via	IN
cord-334907-l4jjb93l	396	11	immunofluorescence	immunofluorescence	NN
cord-334907-l4jjb93l	396	12	using	use	VBG
cord-334907-l4jjb93l	396	13	the	the	DT
cord-334907-l4jjb93l	396	14	ANTIFLAG	ANTIFLAG	NNP
cord-334907-l4jjb93l	396	15	M2	M2	NNP
cord-334907-l4jjb93l	396	16	antibody	antibody	NN
cord-334907-l4jjb93l	396	17	.	.	.
cord-334907-l4jjb93l	397	1	Proteins	protein	NNS
cord-334907-l4jjb93l	397	2	where	where	WRB
cord-334907-l4jjb93l	397	3	detected	detect	VBN
cord-334907-l4jjb93l	397	4	in	in	IN
cord-334907-l4jjb93l	397	5	vesicles	vesicle	NNS
cord-334907-l4jjb93l	397	6	and	and	CC
cord-334907-l4jjb93l	397	7	membranous	membranous	JJ
cord-334907-l4jjb93l	397	8	compartments	compartment	NNS
cord-334907-l4jjb93l	397	9	of	of	IN
cord-334907-l4jjb93l	397	10	the	the	DT
cord-334907-l4jjb93l	397	11	cell	cell	NN
cord-334907-l4jjb93l	397	12	,	,	,
cord-334907-l4jjb93l	397	13	in	in	IN
cord-334907-l4jjb93l	397	14	accordance	accordance	NN
cord-334907-l4jjb93l	397	15	with	with	IN
cord-334907-l4jjb93l	397	16	their	-PRON-	PRP$
cord-334907-l4jjb93l	397	17	membrane	membrane	NN
cord-334907-l4jjb93l	397	18	-	-	HYPH
cord-334907-l4jjb93l	397	19	bound	bind	VBN
cord-334907-l4jjb93l	397	20	nature	nature	NN
cord-334907-l4jjb93l	397	21	.	.	.
cord-334907-l4jjb93l	398	1	All	all	DT
cord-334907-l4jjb93l	398	2	proteins	protein	NNS
cord-334907-l4jjb93l	398	3	had	have	VBD
cord-334907-l4jjb93l	398	4	comparable	comparable	JJ
cord-334907-l4jjb93l	398	5	levels	level	NNS
cord-334907-l4jjb93l	398	6	of	of	IN
cord-334907-l4jjb93l	398	7	expression	expression	NN
cord-334907-l4jjb93l	398	8	,	,	,
cord-334907-l4jjb93l	398	9	as	as	IN
cord-334907-l4jjb93l	398	10	determined	determine	VBN
cord-334907-l4jjb93l	398	11	by	by	IN
cord-334907-l4jjb93l	398	12	fluorescence	fluorescence	NN
cord-334907-l4jjb93l	398	13	intensity	intensity	NN
cord-334907-l4jjb93l	398	14	measurements	measurement	NNS
cord-334907-l4jjb93l	398	15	.	.	.
cord-334907-l4jjb93l	399	1	Hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	399	2	-	-	HYPH
cord-334907-l4jjb93l	399	3	esterase	esterase	NN
cord-334907-l4jjb93l	399	4	and	and	CC
cord-334907-l4jjb93l	399	5	Fusion	Fusion	NNP
cord-334907-l4jjb93l	399	6	Protein	Protein	NNP
cord-334907-l4jjb93l	399	7	constructs	construct	VBZ
cord-334907-l4jjb93l	399	8	appears	appear	VBZ
cord-334907-l4jjb93l	399	9	in	in	IN
cord-334907-l4jjb93l	399	10	green	green	JJ
cord-334907-l4jjb93l	399	11	and	and	CC
cord-334907-l4jjb93l	399	12	red	red	JJ
cord-334907-l4jjb93l	399	13	,	,	,
cord-334907-l4jjb93l	399	14	respectively	respectively	RB
cord-334907-l4jjb93l	399	15	;	;	:
cord-334907-l4jjb93l	399	16	Figure	figure	NN
cord-334907-l4jjb93l	399	17	S2	s2	NN
cord-334907-l4jjb93l	399	18	:	:	:
cord-334907-l4jjb93l	399	19	Co	co	NN
cord-334907-l4jjb93l	399	20	-	-	NN
cord-334907-l4jjb93l	399	21	expression	expression	NN
cord-334907-l4jjb93l	399	22	of	of	IN
cord-334907-l4jjb93l	399	23	HE	HE	NNP
cord-334907-l4jjb93l	399	24	and	and	CC
cord-334907-l4jjb93l	399	25	F	F	NNP
cord-334907-l4jjb93l	399	26	in	in	IN
cord-334907-l4jjb93l	399	27	transfected	transfecte	VBN
cord-334907-l4jjb93l	399	28	CHSE	CHSE	NNP
cord-334907-l4jjb93l	399	29	/	/	SYM
cord-334907-l4jjb93l	399	30	F	F	NNP
cord-334907-l4jjb93l	399	31	cells	cell	NNS
cord-334907-l4jjb93l	399	32	.	.	.
cord-334907-l4jjb93l	400	1	Fusion	fusion	NN
cord-334907-l4jjb93l	400	2	proteins	protein	NNS
cord-334907-l4jjb93l	400	3	for	for	IN
cord-334907-l4jjb93l	400	4	HE	HE	NNP
cord-334907-l4jjb93l	400	5	and	and	CC
cord-334907-l4jjb93l	400	6	F	F	NNP
cord-334907-l4jjb93l	400	7	where	where	WRB
cord-334907-l4jjb93l	400	8	developed	develop	VBD
cord-334907-l4jjb93l	400	9	to	to	TO
cord-334907-l4jjb93l	400	10	assess	assess	VB
cord-334907-l4jjb93l	400	11	the	the	DT
cord-334907-l4jjb93l	400	12	correct	correct	JJ
cord-334907-l4jjb93l	400	13	co	co	NN
cord-334907-l4jjb93l	400	14	-	-	NN
cord-334907-l4jjb93l	400	15	expression	expression	NN
cord-334907-l4jjb93l	400	16	of	of	IN
cord-334907-l4jjb93l	400	17	proteins	protein	NNS
cord-334907-l4jjb93l	400	18	on	on	IN
cord-334907-l4jjb93l	400	19	co	co	NN
cord-334907-l4jjb93l	400	20	-	-	JJ
cord-334907-l4jjb93l	400	21	transfected	transfecte	VBN
cord-334907-l4jjb93l	400	22	cells	cell	NNS
cord-334907-l4jjb93l	400	23	.	.	.
cord-334907-l4jjb93l	401	1	As	as	IN
cord-334907-l4jjb93l	401	2	described	describe	VBN
cord-334907-l4jjb93l	401	3	above	above	RB
cord-334907-l4jjb93l	401	4	,	,	,
cord-334907-l4jjb93l	401	5	both	both	CC
cord-334907-l4jjb93l	401	6	HE	HE	NNP
cord-334907-l4jjb93l	401	7	and	and	CC
cord-334907-l4jjb93l	401	8	F	F	NNP
cord-334907-l4jjb93l	401	9	where	where	WRB
cord-334907-l4jjb93l	401	10	located	locate	VBN
cord-334907-l4jjb93l	401	11	at	at	IN
cord-334907-l4jjb93l	401	12	vesicles	vesicle	NNS
cord-334907-l4jjb93l	401	13	and	and	CC
cord-334907-l4jjb93l	401	14	membranous	membranous	JJ
cord-334907-l4jjb93l	401	15	compartments	compartment	NNS
cord-334907-l4jjb93l	401	16	of	of	IN
cord-334907-l4jjb93l	401	17	the	the	DT
cord-334907-l4jjb93l	401	18	cell	cell	NN
cord-334907-l4jjb93l	401	19	,	,	,
cord-334907-l4jjb93l	401	20	in	in	IN
cord-334907-l4jjb93l	401	21	accordance	accordance	NN
cord-334907-l4jjb93l	401	22	with	with	IN
cord-334907-l4jjb93l	401	23	their	-PRON-	PRP$
cord-334907-l4jjb93l	401	24	membrane	membrane	NN
cord-334907-l4jjb93l	401	25	-	-	HYPH
cord-334907-l4jjb93l	401	26	bound	bind	VBN
cord-334907-l4jjb93l	401	27	nature	nature	NN
cord-334907-l4jjb93l	401	28	;	;	:
cord-334907-l4jjb93l	401	29	Figure	figure	NN
cord-334907-l4jjb93l	401	30	S3	s3	NN
cord-334907-l4jjb93l	401	31	:	:	:
cord-334907-l4jjb93l	401	32	Hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	401	33	levels	level	NNS
cord-334907-l4jjb93l	401	34	for	for	IN
cord-334907-l4jjb93l	401	35	CHSE	CHSE	NNP
cord-334907-l4jjb93l	401	36	/	/	SYM
cord-334907-l4jjb93l	401	37	F	F	NNP
cord-334907-l4jjb93l	401	38	expressed	express	VBD
cord-334907-l4jjb93l	401	39	HEs	HEs	NNP
cord-334907-l4jjb93l	401	40	.	.	.
cord-334907-l4jjb93l	402	1	Forty	forty	CD
cord-334907-l4jjb93l	402	2	-	-	HYPH
cord-334907-l4jjb93l	402	3	eight	eight	CD
cord-334907-l4jjb93l	402	4	hours	hour	NNS
cord-334907-l4jjb93l	402	5	post	post	NN
cord-334907-l4jjb93l	402	6	transfection	transfection	NN
cord-334907-l4jjb93l	402	7	,	,	,
cord-334907-l4jjb93l	402	8	salmon	salmon	NN
cord-334907-l4jjb93l	402	9	RBCs	rbc	NNS
cord-334907-l4jjb93l	402	10	were	be	VBD
cord-334907-l4jjb93l	402	11	added	add	VBN
cord-334907-l4jjb93l	402	12	to	to	IN
cord-334907-l4jjb93l	402	13	CHSE	CHSE	NNP
cord-334907-l4jjb93l	402	14	/	/	SYM
cord-334907-l4jjb93l	402	15	F	F	NNP
cord-334907-l4jjb93l	402	16	cells	cell	NNS
cord-334907-l4jjb93l	402	17	and	and	CC
cord-334907-l4jjb93l	402	18	hemadsorption	hemadsorption	NN
cord-334907-l4jjb93l	402	19	levels	level	NNS
cord-334907-l4jjb93l	402	20	were	be	VBD
cord-334907-l4jjb93l	402	21	assessed	assess	VBN
cord-334907-l4jjb93l	402	22	measuring	measure	VBG
cord-334907-l4jjb93l	402	23	the	the	DT
cord-334907-l4jjb93l	402	24	hemoglobin	hemoglobin	NN
cord-334907-l4jjb93l	402	25	released	release	VBN
cord-334907-l4jjb93l	402	26	after	after	IN
cord-334907-l4jjb93l	402	27	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	402	28	were	be	VBD
cord-334907-l4jjb93l	402	29	permeabilized	permeabilize	VBN
cord-334907-l4jjb93l	402	30	,	,	,
cord-334907-l4jjb93l	402	31	via	via	IN
cord-334907-l4jjb93l	402	32	spectrophotometry	spectrophotometry	NN
cord-334907-l4jjb93l	402	33	.	.	.
cord-334907-l4jjb93l	403	1	The	the	DT
cord-334907-l4jjb93l	403	2	graph	graph	NN
cord-334907-l4jjb93l	403	3	shows	show	VBZ
cord-334907-l4jjb93l	403	4	the	the	DT
cord-334907-l4jjb93l	403	5	absorbance	absorbance	NN
cord-334907-l4jjb93l	403	6	at	at	IN
cord-334907-l4jjb93l	403	7	540	540	CD
cord-334907-l4jjb93l	403	8	nm	nm	NN
cord-334907-l4jjb93l	403	9	for	for	IN
cord-334907-l4jjb93l	403	10	triplicate	triplicate	JJ
cord-334907-l4jjb93l	403	11	samples	sample	NNS
cord-334907-l4jjb93l	403	12	.	.	.
cord-334907-l4jjb93l	404	1	There	there	EX
cord-334907-l4jjb93l	404	2	was	be	VBD
cord-334907-l4jjb93l	404	3	no	no	DT
cord-334907-l4jjb93l	404	4	significant	significant	JJ
cord-334907-l4jjb93l	404	5	difference	difference	NN
cord-334907-l4jjb93l	404	6	between	between	IN
cord-334907-l4jjb93l	404	7	the	the	DT
cord-334907-l4jjb93l	404	8	HE	HE	NNP
cord-334907-l4jjb93l	404	9	constructs	construct	VBZ
cord-334907-l4jjb93l	404	10	.	.	.
cord-334907-l4jjb93l	405	1	Release	release	NN
cord-334907-l4jjb93l	405	2	and	and	CC
cord-334907-l4jjb93l	405	3	survival	survival	NN
cord-334907-l4jjb93l	405	4	of	of	IN
cord-334907-l4jjb93l	405	5	infectious	infectious	JJ
cord-334907-l4jjb93l	405	6	salmon	salmon	NN
cord-334907-l4jjb93l	405	7	anaemia	anaemia	NN
cord-334907-l4jjb93l	405	8	(	(	-LRB-
cord-334907-l4jjb93l	405	9	ISA	ISA	NNP
cord-334907-l4jjb93l	405	10	)	)	-RRB-
cord-334907-l4jjb93l	405	11	virus	virus	NN
cord-334907-l4jjb93l	405	12	during	during	IN
cord-334907-l4jjb93l	405	13	decomposition	decomposition	NN
cord-334907-l4jjb93l	405	14	of	of	IN
cord-334907-l4jjb93l	405	15	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	405	16	salmon	salmon	NN
cord-334907-l4jjb93l	406	1	(	(	-LRB-
cord-334907-l4jjb93l	406	2	Salmo	Salmo	NNP
cord-334907-l4jjb93l	406	3	salar	salar	NNP
cord-334907-l4jjb93l	406	4	L.	L.	NNP
cord-334907-l4jjb93l	406	5	)	)	-RRB-
cord-334907-l4jjb93l	406	6	Infectious	infectious	JJ
cord-334907-l4jjb93l	406	7	salmon	salmon	NN
cord-334907-l4jjb93l	406	8	anaemia	anaemia	NN
cord-334907-l4jjb93l	406	9	in	in	IN
cord-334907-l4jjb93l	406	10	salt	salt	NN
cord-334907-l4jjb93l	406	11	water	water	NN
cord-334907-l4jjb93l	407	1	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	407	2	salmon	salmon	NN
cord-334907-l4jjb93l	408	1	(	(	-LRB-
cord-334907-l4jjb93l	408	2	Salmo	Salmo	NNP
cord-334907-l4jjb93l	408	3	salar	salar	NNP
cord-334907-l4jjb93l	408	4	L	L	NNP
cord-334907-l4jjb93l	408	5	Infectious	infectious	JJ
cord-334907-l4jjb93l	408	6	anaemia	anaemia	NN
cord-334907-l4jjb93l	408	7	in	in	IN
cord-334907-l4jjb93l	408	8	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	408	9	salmon	salmon	NN
cord-334907-l4jjb93l	409	1	(	(	-LRB-
cord-334907-l4jjb93l	409	2	SALMO	SALMO	NNP
cord-334907-l4jjb93l	409	3	SALAR	SALAR	NNP
cord-334907-l4jjb93l	409	4	L.	L.	NNP
cord-334907-l4jjb93l	409	5	)	)	-RRB-
cord-334907-l4jjb93l	410	1	Infectious	infectious	JJ
cord-334907-l4jjb93l	410	2	salmon	salmon	NN
cord-334907-l4jjb93l	410	3	anaemia	anaemia	NN
cord-334907-l4jjb93l	411	1	(	(	-LRB-
cord-334907-l4jjb93l	411	2	ISA	ISA	NNP
cord-334907-l4jjb93l	411	3	)	)	-RRB-
cord-334907-l4jjb93l	411	4	in	in	IN
cord-334907-l4jjb93l	411	5	the	the	DT
cord-334907-l4jjb93l	411	6	United	United	NNP
cord-334907-l4jjb93l	411	7	Kingdom	Kingdom	NNP
cord-334907-l4jjb93l	411	8	First	First	NNP
cord-334907-l4jjb93l	411	9	detection	detection	NN
cord-334907-l4jjb93l	411	10	,	,	,
cord-334907-l4jjb93l	411	11	isolation	isolation	NN
cord-334907-l4jjb93l	411	12	and	and	CC
cord-334907-l4jjb93l	411	13	molecular	molecular	JJ
cord-334907-l4jjb93l	411	14	characterization	characterization	NN
cord-334907-l4jjb93l	411	15	of	of	IN
cord-334907-l4jjb93l	411	16	infectious	infectious	JJ
cord-334907-l4jjb93l	411	17	salmon	salmon	NN
cord-334907-l4jjb93l	411	18	anaemia	anaemia	NN
cord-334907-l4jjb93l	411	19	virus	virus	NN
cord-334907-l4jjb93l	411	20	associated	associate	VBN
cord-334907-l4jjb93l	411	21	with	with	IN
cord-334907-l4jjb93l	411	22	clinical	clinical	JJ
cord-334907-l4jjb93l	411	23	disease	disease	NN
cord-334907-l4jjb93l	411	24	in	in	IN
cord-334907-l4jjb93l	411	25	farmed	farm	VBN
cord-334907-l4jjb93l	411	26	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	411	27	salmon	salmon	NN
cord-334907-l4jjb93l	411	28	(	(	-LRB-
cord-334907-l4jjb93l	411	29	Salmo	Salmo	NNP
cord-334907-l4jjb93l	411	30	salar	salar	NN
cord-334907-l4jjb93l	411	31	)	)	-RRB-
cord-334907-l4jjb93l	411	32	in	in	IN
cord-334907-l4jjb93l	411	33	Chile	Chile	NNP
cord-334907-l4jjb93l	411	34	A	a	DT
cord-334907-l4jjb93l	411	35	low	low	RB
cord-334907-l4jjb93l	411	36	-	-	HYPH
cord-334907-l4jjb93l	411	37	pathogenic	pathogenic	JJ
cord-334907-l4jjb93l	411	38	variant	variant	NN
cord-334907-l4jjb93l	411	39	of	of	IN
cord-334907-l4jjb93l	411	40	infectious	infectious	JJ
cord-334907-l4jjb93l	411	41	salmon	salmon	NN
cord-334907-l4jjb93l	411	42	anemia	anemia	NN
cord-334907-l4jjb93l	411	43	virus	virus	NN
cord-334907-l4jjb93l	411	44	(	(	-LRB-
cord-334907-l4jjb93l	411	45	ISAV	ISAV	NNP
cord-334907-l4jjb93l	411	46	-	-	HYPH
cord-334907-l4jjb93l	411	47	HPR0	HPR0	NNP
cord-334907-l4jjb93l	411	48	)	)	-RRB-
cord-334907-l4jjb93l	411	49	is	be	VBZ
cord-334907-l4jjb93l	411	50	highly	highly	RB
cord-334907-l4jjb93l	411	51	prevalent	prevalent	JJ
cord-334907-l4jjb93l	411	52	and	and	CC
cord-334907-l4jjb93l	411	53	causes	cause	VBZ
cord-334907-l4jjb93l	411	54	a	a	DT
cord-334907-l4jjb93l	411	55	non	non	JJ
cord-334907-l4jjb93l	411	56	-	-	JJ
cord-334907-l4jjb93l	411	57	clinical	clinical	JJ
cord-334907-l4jjb93l	411	58	transient	transient	JJ
cord-334907-l4jjb93l	411	59	infection	infection	NN
cord-334907-l4jjb93l	411	60	in	in	IN
cord-334907-l4jjb93l	411	61	farmed	farm	VBN
cord-334907-l4jjb93l	411	62	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	411	63	salmon	salmon	NN
cord-334907-l4jjb93l	411	64	(	(	-LRB-
cord-334907-l4jjb93l	411	65	Salmo	Salmo	NNP
cord-334907-l4jjb93l	411	66	salar	salar	NNP
cord-334907-l4jjb93l	411	67	L.	L.	NNP
cord-334907-l4jjb93l	411	68	)	)	-RRB-
cord-334907-l4jjb93l	411	69	in	in	IN
cord-334907-l4jjb93l	411	70	the	the	DT
cord-334907-l4jjb93l	411	71	Faroe	Faroe	NNP
cord-334907-l4jjb93l	411	72	Islands	Islands	NNPS
cord-334907-l4jjb93l	412	1	The	the	DT
cord-334907-l4jjb93l	412	2	putative	putative	JJ
cord-334907-l4jjb93l	412	3	polymerase	polymerase	NN
cord-334907-l4jjb93l	412	4	sequence	sequence	NN
cord-334907-l4jjb93l	412	5	of	of	IN
cord-334907-l4jjb93l	412	6	infectious	infectious	JJ
cord-334907-l4jjb93l	412	7	salmon	salmon	NN
cord-334907-l4jjb93l	412	8	anemia	anemia	NN
cord-334907-l4jjb93l	412	9	virus	virus	NN
cord-334907-l4jjb93l	412	10	suggests	suggest	VBZ
cord-334907-l4jjb93l	412	11	a	a	DT
cord-334907-l4jjb93l	412	12	new	new	JJ
cord-334907-l4jjb93l	412	13	genus	genus	NN
cord-334907-l4jjb93l	412	14	within	within	IN
cord-334907-l4jjb93l	412	15	the	the	DT
cord-334907-l4jjb93l	412	16	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-334907-l4jjb93l	412	17	Genomic	Genomic	NNP
cord-334907-l4jjb93l	412	18	organization	organization	NN
cord-334907-l4jjb93l	412	19	of	of	IN
cord-334907-l4jjb93l	412	20	infectious	infectious	JJ
cord-334907-l4jjb93l	412	21	salmon	salmon	NN
cord-334907-l4jjb93l	412	22	anaemia	anaemia	NN
cord-334907-l4jjb93l	412	23	virus	virus	NN
cord-334907-l4jjb93l	412	24	Isolation	isolation	NN
cord-334907-l4jjb93l	412	25	of	of	IN
cord-334907-l4jjb93l	412	26	the	the	DT
cord-334907-l4jjb93l	412	27	causal	causal	JJ
cord-334907-l4jjb93l	412	28	virus	virus	NN
cord-334907-l4jjb93l	412	29	of	of	IN
cord-334907-l4jjb93l	412	30	infectious	infectious	JJ
cord-334907-l4jjb93l	412	31	salmon	salmon	NN
cord-334907-l4jjb93l	412	32	anaemia	anaemia	NN
cord-334907-l4jjb93l	412	33	(	(	-LRB-
cord-334907-l4jjb93l	412	34	ISA	ISA	NNP
cord-334907-l4jjb93l	412	35	)	)	-RRB-
cord-334907-l4jjb93l	412	36	in	in	IN
cord-334907-l4jjb93l	412	37	a	a	DT
cord-334907-l4jjb93l	412	38	long	long	JJ
cord-334907-l4jjb93l	412	39	-	-	HYPH
cord-334907-l4jjb93l	412	40	term	term	NN
cord-334907-l4jjb93l	412	41	cell	cell	NN
cord-334907-l4jjb93l	412	42	line	line	NN
cord-334907-l4jjb93l	412	43	from	from	IN
cord-334907-l4jjb93l	412	44	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	412	45	salmon	salmon	NN
cord-334907-l4jjb93l	412	46	head	head	NN
cord-334907-l4jjb93l	412	47	kidney	kidney	NN
cord-334907-l4jjb93l	412	48	Structural	structural	JJ
cord-334907-l4jjb93l	412	49	and	and	CC
cord-334907-l4jjb93l	412	50	functional	functional	JJ
cord-334907-l4jjb93l	412	51	analysis	analysis	NN
cord-334907-l4jjb93l	412	52	of	of	IN
cord-334907-l4jjb93l	412	53	the	the	DT
cord-334907-l4jjb93l	412	54	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	412	55	-	-	HYPH
cord-334907-l4jjb93l	412	56	esterase	esterase	NN
cord-334907-l4jjb93l	412	57	of	of	IN
cord-334907-l4jjb93l	412	58	infectious	infectious	JJ
cord-334907-l4jjb93l	412	59	salmon	salmon	NN
cord-334907-l4jjb93l	412	60	anaemia	anaemia	NN
cord-334907-l4jjb93l	412	61	virus	virus	NN
cord-334907-l4jjb93l	412	62	Structure	Structure	NNP
cord-334907-l4jjb93l	412	63	of	of	IN
cord-334907-l4jjb93l	412	64	the	the	DT
cord-334907-l4jjb93l	412	65	infectious	infectious	JJ
cord-334907-l4jjb93l	412	66	salmon	salmon	NN
cord-334907-l4jjb93l	412	67	anemia	anemia	NN
cord-334907-l4jjb93l	412	68	virus	virus	NN
cord-334907-l4jjb93l	412	69	receptor	receptor	NN
cord-334907-l4jjb93l	412	70	complex	complex	NN
cord-334907-l4jjb93l	412	71	illustrates	illustrate	VBZ
cord-334907-l4jjb93l	412	72	a	a	DT
cord-334907-l4jjb93l	412	73	unique	unique	JJ
cord-334907-l4jjb93l	412	74	binding	binding	JJ
cord-334907-l4jjb93l	412	75	strategy	strategy	NN
cord-334907-l4jjb93l	412	76	for	for	IN
cord-334907-l4jjb93l	412	77	attachment	attachment	NN
cord-334907-l4jjb93l	412	78	Characterization	characterization	NN
cord-334907-l4jjb93l	412	79	of	of	IN
cord-334907-l4jjb93l	412	80	the	the	DT
cord-334907-l4jjb93l	412	81	Infectious	Infectious	NNP
cord-334907-l4jjb93l	412	82	Salmon	Salmon	NNP
cord-334907-l4jjb93l	412	83	Anemia	Anemia	NNP
cord-334907-l4jjb93l	412	84	Virus	Virus	NNP
cord-334907-l4jjb93l	412	85	Fusion	Fusion	NNP
cord-334907-l4jjb93l	412	86	Protein	Protein	NNP
cord-334907-l4jjb93l	412	87	Electrostatic	Electrostatic	NNP
cord-334907-l4jjb93l	412	88	Architecture	Architecture	NNP
cord-334907-l4jjb93l	412	89	of	of	IN
cord-334907-l4jjb93l	412	90	the	the	DT
cord-334907-l4jjb93l	412	91	Infectious	Infectious	NNP
cord-334907-l4jjb93l	412	92	Salmon	Salmon	NNP
cord-334907-l4jjb93l	412	93	Anemia	Anemia	NNP
cord-334907-l4jjb93l	412	94	Virus	virus	NN
cord-334907-l4jjb93l	412	95	(	(	-LRB-
cord-334907-l4jjb93l	412	96	ISAV	ISAV	NNP
cord-334907-l4jjb93l	412	97	)	)	-RRB-
cord-334907-l4jjb93l	413	1	Core	Core	NNP
cord-334907-l4jjb93l	413	2	Fusion	Fusion	NNP
cord-334907-l4jjb93l	413	3	Protein	Protein	NNP
cord-334907-l4jjb93l	413	4	Illustrates	illustrate	VBZ
cord-334907-l4jjb93l	413	5	a	a	DT
cord-334907-l4jjb93l	413	6	Carboxyl	Carboxyl	NNP
cord-334907-l4jjb93l	413	7	-	-	HYPH
cord-334907-l4jjb93l	413	8	Carboxylate	Carboxylate	NNP
cord-334907-l4jjb93l	413	9	pH	pH	NNP
cord-334907-l4jjb93l	413	10	Sensor	Sensor	NNP
cord-334907-l4jjb93l	413	11	Genetic	genetic	JJ
cord-334907-l4jjb93l	413	12	analysis	analysis	NN
cord-334907-l4jjb93l	413	13	and	and	CC
cord-334907-l4jjb93l	413	14	comparative	comparative	JJ
cord-334907-l4jjb93l	413	15	virulence	virulence	NN
cord-334907-l4jjb93l	413	16	of	of	IN
cord-334907-l4jjb93l	413	17	infectious	infectious	JJ
cord-334907-l4jjb93l	413	18	salmon	salmon	NN
cord-334907-l4jjb93l	413	19	anemia	anemia	NN
cord-334907-l4jjb93l	413	20	virus	virus	NN
cord-334907-l4jjb93l	413	21	(	(	-LRB-
cord-334907-l4jjb93l	413	22	ISAV	ISAV	NNP
cord-334907-l4jjb93l	413	23	)	)	-RRB-
cord-334907-l4jjb93l	413	24	types	type	VBZ
cord-334907-l4jjb93l	413	25	HPR7a	HPR7a	NNP
cord-334907-l4jjb93l	413	26	and	and	CC
cord-334907-l4jjb93l	413	27	HPR7b	HPR7b	NNP
cord-334907-l4jjb93l	413	28	from	from	IN
cord-334907-l4jjb93l	413	29	recent	recent	JJ
cord-334907-l4jjb93l	413	30	field	field	NN
cord-334907-l4jjb93l	413	31	outbreaks	outbreak	NNS
cord-334907-l4jjb93l	413	32	in	in	IN
cord-334907-l4jjb93l	413	33	Chile	Chile	NNP
cord-334907-l4jjb93l	413	34	Sequence	Sequence	NNP
cord-334907-l4jjb93l	413	35	analysis	analysis	NN
cord-334907-l4jjb93l	413	36	of	of	IN
cord-334907-l4jjb93l	413	37	the	the	DT
cord-334907-l4jjb93l	413	38	fusion	fusion	NN
cord-334907-l4jjb93l	413	39	protein	protein	NN
cord-334907-l4jjb93l	413	40	gene	gene	NN
cord-334907-l4jjb93l	413	41	from	from	IN
cord-334907-l4jjb93l	413	42	infectious	infectious	JJ
cord-334907-l4jjb93l	413	43	salmon	salmon	NN
cord-334907-l4jjb93l	413	44	anemia	anemia	NN
cord-334907-l4jjb93l	413	45	virus	virus	NN
cord-334907-l4jjb93l	414	1	isolates	isolate	NNS
cord-334907-l4jjb93l	414	2	:	:	:
cord-334907-l4jjb93l	415	1	Evidence	evidence	NN
cord-334907-l4jjb93l	415	2	of	of	IN
cord-334907-l4jjb93l	415	3	recombination	recombination	NN
cord-334907-l4jjb93l	415	4	and	and	CC
cord-334907-l4jjb93l	415	5	reassortment	reassortment	VB
cord-334907-l4jjb93l	415	6	A	a	DT
cord-334907-l4jjb93l	415	7	novel	novel	JJ
cord-334907-l4jjb93l	415	8	variant	variant	NN
cord-334907-l4jjb93l	415	9	of	of	IN
cord-334907-l4jjb93l	415	10	the	the	DT
cord-334907-l4jjb93l	415	11	infectious	infectious	JJ
cord-334907-l4jjb93l	415	12	salmon	salmon	NN
cord-334907-l4jjb93l	415	13	anaemia	anaemia	NN
cord-334907-l4jjb93l	415	14	virus	virus	NN
cord-334907-l4jjb93l	415	15	(	(	-LRB-
cord-334907-l4jjb93l	415	16	ISAV	ISAV	NNP
cord-334907-l4jjb93l	415	17	)	)	-RRB-
cord-334907-l4jjb93l	415	18	haemagglutinin	haemagglutinin	NNP
cord-334907-l4jjb93l	415	19	gene	gene	NN
cord-334907-l4jjb93l	415	20	suggests	suggest	VBZ
cord-334907-l4jjb93l	415	21	mechanisms	mechanism	NNS
cord-334907-l4jjb93l	415	22	for	for	IN
cord-334907-l4jjb93l	415	23	virus	virus	NN
cord-334907-l4jjb93l	415	24	diversity	diversity	NN
cord-334907-l4jjb93l	415	25	Low	low	JJ
cord-334907-l4jjb93l	415	26	virulent	virulent	JJ
cord-334907-l4jjb93l	415	27	infectious	infectious	JJ
cord-334907-l4jjb93l	415	28	salmon	salmon	NN
cord-334907-l4jjb93l	415	29	anaemia	anaemia	NN
cord-334907-l4jjb93l	415	30	virus	virus	NN
cord-334907-l4jjb93l	415	31	(	(	-LRB-
cord-334907-l4jjb93l	415	32	ISAV	ISAV	NNP
cord-334907-l4jjb93l	415	33	-	-	HYPH
cord-334907-l4jjb93l	415	34	HPR0	HPR0	NNP
cord-334907-l4jjb93l	415	35	)	)	-RRB-
cord-334907-l4jjb93l	415	36	is	be	VBZ
cord-334907-l4jjb93l	415	37	prevalent	prevalent	JJ
cord-334907-l4jjb93l	415	38	and	and	CC
cord-334907-l4jjb93l	415	39	geographically	geographically	RB
cord-334907-l4jjb93l	415	40	structured	structured	JJ
cord-334907-l4jjb93l	415	41	in	in	IN
cord-334907-l4jjb93l	415	42	Norwegian	norwegian	JJ
cord-334907-l4jjb93l	415	43	salmon	salmon	NN
cord-334907-l4jjb93l	415	44	farming	farming	NN
cord-334907-l4jjb93l	415	45	Presence	Presence	NNP
cord-334907-l4jjb93l	415	46	of	of	IN
cord-334907-l4jjb93l	415	47	a	a	DT
cord-334907-l4jjb93l	415	48	full	full	JJ
cord-334907-l4jjb93l	415	49	-	-	HYPH
cord-334907-l4jjb93l	415	50	length	length	NN
cord-334907-l4jjb93l	415	51	highly	highly	RB
cord-334907-l4jjb93l	415	52	polymorphic	polymorphic	JJ
cord-334907-l4jjb93l	415	53	region	region	NN
cord-334907-l4jjb93l	415	54	(	(	-LRB-
cord-334907-l4jjb93l	415	55	HPR	HPR	NNP
cord-334907-l4jjb93l	415	56	)	)	-RRB-
cord-334907-l4jjb93l	415	57	in	in	IN
cord-334907-l4jjb93l	415	58	the	the	DT
cord-334907-l4jjb93l	415	59	ISAV	ISAV	NNP
cord-334907-l4jjb93l	415	60	haemagglutinin	haemagglutinin	NNP
cord-334907-l4jjb93l	415	61	-	-	HYPH
cord-334907-l4jjb93l	415	62	esterase	esterase	NN
cord-334907-l4jjb93l	415	63	does	do	VBZ
cord-334907-l4jjb93l	415	64	not	not	RB
cord-334907-l4jjb93l	415	65	affect	affect	VB
cord-334907-l4jjb93l	415	66	the	the	DT
cord-334907-l4jjb93l	415	67	primary	primary	JJ
cord-334907-l4jjb93l	415	68	functions	function	NNS
cord-334907-l4jjb93l	415	69	of	of	IN
cord-334907-l4jjb93l	415	70	receptor	receptor	NN
cord-334907-l4jjb93l	415	71	binding	binding	NN
cord-334907-l4jjb93l	415	72	and	and	CC
cord-334907-l4jjb93l	415	73	esterase	esterase	NN
cord-334907-l4jjb93l	415	74	activity	activity	NN
cord-334907-l4jjb93l	416	1	Deletions	deletion	NNS
cord-334907-l4jjb93l	416	2	in	in	IN
cord-334907-l4jjb93l	416	3	the	the	DT
cord-334907-l4jjb93l	416	4	highly	highly	RB
cord-334907-l4jjb93l	416	5	polymorphic	polymorphic	JJ
cord-334907-l4jjb93l	416	6	region	region	NN
cord-334907-l4jjb93l	416	7	(	(	-LRB-
cord-334907-l4jjb93l	416	8	HPR	HPR	NNP
cord-334907-l4jjb93l	416	9	)	)	-RRB-
cord-334907-l4jjb93l	416	10	of	of	IN
cord-334907-l4jjb93l	416	11	infectious	infectious	JJ
cord-334907-l4jjb93l	416	12	salmon	salmon	NN
cord-334907-l4jjb93l	416	13	anaemia	anaemia	NN
cord-334907-l4jjb93l	416	14	virus	virus	NN
cord-334907-l4jjb93l	417	1	HPR0	HPR0	NNP
cord-334907-l4jjb93l	417	2	haemagglutinin	haemagglutinin	NN
cord-334907-l4jjb93l	417	3	-	-	HYPH
cord-334907-l4jjb93l	417	4	esterase	esterase	NN
cord-334907-l4jjb93l	417	5	enhance	enhance	VB
cord-334907-l4jjb93l	417	6	viral	viral	JJ
cord-334907-l4jjb93l	417	7	fusion	fusion	NN
cord-334907-l4jjb93l	417	8	and	and	CC
cord-334907-l4jjb93l	417	9	influence	influence	VB
cord-334907-l4jjb93l	417	10	the	the	DT
cord-334907-l4jjb93l	417	11	interaction	interaction	NN
cord-334907-l4jjb93l	417	12	with	with	IN
cord-334907-l4jjb93l	417	13	the	the	DT
cord-334907-l4jjb93l	417	14	fusion	fusion	NN
cord-334907-l4jjb93l	417	15	protein	protein	NN
cord-334907-l4jjb93l	417	16	Influenza	Influenza	NNP
cord-334907-l4jjb93l	417	17	Hemagglutinin	Hemagglutinin	NNP
cord-334907-l4jjb93l	417	18	and	and	CC
cord-334907-l4jjb93l	417	19	Neuraminidase	Neuraminidase	NNP
cord-334907-l4jjb93l	418	1	Membrane	membrane	NN
cord-334907-l4jjb93l	418	2	Glycoproteins	Glycoproteins	NNP
cord-334907-l4jjb93l	418	3	Neuraminidase	Neuraminidase	NNP
cord-334907-l4jjb93l	418	4	is	be	VBZ
cord-334907-l4jjb93l	418	5	important	important	JJ
cord-334907-l4jjb93l	418	6	for	for	IN
cord-334907-l4jjb93l	418	7	the	the	DT
cord-334907-l4jjb93l	418	8	initiation	initiation	NN
cord-334907-l4jjb93l	418	9	of	of	IN
cord-334907-l4jjb93l	418	10	influenza	influenza	NN
cord-334907-l4jjb93l	418	11	virus	virus	NN
cord-334907-l4jjb93l	418	12	infection	infection	NN
cord-334907-l4jjb93l	418	13	in	in	IN
cord-334907-l4jjb93l	418	14	human	human	JJ
cord-334907-l4jjb93l	418	15	airway	airway	NN
cord-334907-l4jjb93l	418	16	epithelium	epithelium	NN
cord-334907-l4jjb93l	418	17	Roles	role	NNS
cord-334907-l4jjb93l	418	18	of	of	IN
cord-334907-l4jjb93l	418	19	neuraminidase	neuraminidase	NN
cord-334907-l4jjb93l	418	20	in	in	IN
cord-334907-l4jjb93l	418	21	the	the	DT
cord-334907-l4jjb93l	418	22	initial	initial	JJ
cord-334907-l4jjb93l	418	23	stage	stage	NN
cord-334907-l4jjb93l	418	24	of	of	IN
cord-334907-l4jjb93l	418	25	influenza	influenza	NN
cord-334907-l4jjb93l	418	26	virus	virus	NN
cord-334907-l4jjb93l	418	27	infection	infection	NN
cord-334907-l4jjb93l	419	1	A	a	DT
cord-334907-l4jjb93l	419	2	27-amino	27-amino	CD
cord-334907-l4jjb93l	419	3	-	-	HYPH
cord-334907-l4jjb93l	419	4	acid	acid	NN
cord-334907-l4jjb93l	419	5	deletion	deletion	NN
cord-334907-l4jjb93l	419	6	in	in	IN
cord-334907-l4jjb93l	419	7	the	the	DT
cord-334907-l4jjb93l	419	8	neuraminidase	neuraminidase	NN
cord-334907-l4jjb93l	419	9	stalk	stalk	NN
cord-334907-l4jjb93l	419	10	supports	support	VBZ
cord-334907-l4jjb93l	419	11	replication	replication	NN
cord-334907-l4jjb93l	419	12	of	of	IN
cord-334907-l4jjb93l	419	13	an	an	DT
cord-334907-l4jjb93l	419	14	avian	avian	JJ
cord-334907-l4jjb93l	419	15	H2N2	H2N2	NNP
cord-334907-l4jjb93l	419	16	influenza	influenza	NN
cord-334907-l4jjb93l	419	17	A	a	DT
cord-334907-l4jjb93l	419	18	virus	virus	NN
cord-334907-l4jjb93l	419	19	in	in	IN
cord-334907-l4jjb93l	419	20	the	the	DT
cord-334907-l4jjb93l	419	21	respiratory	respiratory	JJ
cord-334907-l4jjb93l	419	22	tract	tract	NN
cord-334907-l4jjb93l	419	23	of	of	IN
cord-334907-l4jjb93l	419	24	chickens	chicken	NNS
cord-334907-l4jjb93l	419	25	The	the	DT
cord-334907-l4jjb93l	419	26	Neuraminidase	Neuraminidase	NNP
cord-334907-l4jjb93l	419	27	Stalk	stalk	VB
cord-334907-l4jjb93l	419	28	Deletion	deletion	NN
cord-334907-l4jjb93l	419	29	Serves	serve	VBZ
cord-334907-l4jjb93l	419	30	as	as	IN
cord-334907-l4jjb93l	419	31	Major	Major	NNP
cord-334907-l4jjb93l	419	32	Virulence	Virulence	NNP
cord-334907-l4jjb93l	419	33	Determinant	Determinant	NNP
cord-334907-l4jjb93l	419	34	of	of	IN
cord-334907-l4jjb93l	419	35	H5N1	H5N1	NNP
cord-334907-l4jjb93l	419	36	Highly	highly	RB
cord-334907-l4jjb93l	419	37	Pathogenic	pathogenic	JJ
cord-334907-l4jjb93l	419	38	Avian	avian	JJ
cord-334907-l4jjb93l	419	39	Influenza	influenza	NN
cord-334907-l4jjb93l	419	40	Viruses	Viruses	NNPS
cord-334907-l4jjb93l	419	41	in	in	IN
cord-334907-l4jjb93l	419	42	Chicken	Chicken	NNP
cord-334907-l4jjb93l	419	43	Biophysical	Biophysical	NNP
cord-334907-l4jjb93l	419	44	measurement	measurement	NN
cord-334907-l4jjb93l	419	45	of	of	IN
cord-334907-l4jjb93l	419	46	the	the	DT
cord-334907-l4jjb93l	419	47	balance	balance	NN
cord-334907-l4jjb93l	419	48	of	of	IN
cord-334907-l4jjb93l	419	49	influenza	influenza	NN
cord-334907-l4jjb93l	419	50	a	a	DT
cord-334907-l4jjb93l	419	51	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	419	52	and	and	CC
cord-334907-l4jjb93l	419	53	neuraminidase	neuraminidase	NN
cord-334907-l4jjb93l	420	1	activities	activity	NNS
cord-334907-l4jjb93l	421	1	Single	single	JJ
cord-334907-l4jjb93l	421	2	event	event	NN
cord-334907-l4jjb93l	421	3	recording	recording	NN
cord-334907-l4jjb93l	421	4	shows	show	VBZ
cord-334907-l4jjb93l	421	5	that	that	IN
cord-334907-l4jjb93l	421	6	docking	dock	VBG
cord-334907-l4jjb93l	421	7	onto	onto	IN
cord-334907-l4jjb93l	421	8	receptor	receptor	NN
cord-334907-l4jjb93l	421	9	alters	alter	VBZ
cord-334907-l4jjb93l	421	10	the	the	DT
cord-334907-l4jjb93l	421	11	kinetics	kinetic	NNS
cord-334907-l4jjb93l	421	12	of	of	IN
cord-334907-l4jjb93l	421	13	membrane	membrane	NN
cord-334907-l4jjb93l	421	14	fusion	fusion	NN
cord-334907-l4jjb93l	421	15	mediated	mediate	VBN
cord-334907-l4jjb93l	421	16	by	by	IN
cord-334907-l4jjb93l	421	17	influenza	influenza	NN
cord-334907-l4jjb93l	421	18	hemagglutinin	hemagglutinin	NNP
cord-334907-l4jjb93l	421	19	Expression	expression	NN
cord-334907-l4jjb93l	421	20	of	of	IN
cord-334907-l4jjb93l	421	21	the	the	DT
cord-334907-l4jjb93l	421	22	Infectious	Infectious	NNP
cord-334907-l4jjb93l	421	23	Salmon	Salmon	NNP
cord-334907-l4jjb93l	421	24	Anemia	Anemia	NNP
cord-334907-l4jjb93l	421	25	Virus	Virus	NNP
cord-334907-l4jjb93l	421	26	Receptor	Receptor	NNP
cord-334907-l4jjb93l	421	27	on	on	IN
cord-334907-l4jjb93l	421	28	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	421	29	Salmon	Salmon	NNP
cord-334907-l4jjb93l	421	30	Endothelial	Endothelial	NNP
cord-334907-l4jjb93l	421	31	Cells	Cells	NNPS
cord-334907-l4jjb93l	421	32	Correlates	correlate	VBZ
cord-334907-l4jjb93l	421	33	with	with	IN
cord-334907-l4jjb93l	421	34	the	the	DT
cord-334907-l4jjb93l	421	35	Cell	Cell	NNP
cord-334907-l4jjb93l	421	36	Tropism	tropism	NN
cord-334907-l4jjb93l	421	37	of	of	IN
cord-334907-l4jjb93l	421	38	the	the	DT
cord-334907-l4jjb93l	421	39	Virus	Virus	NNP
cord-334907-l4jjb93l	421	40	Infectious	infectious	JJ
cord-334907-l4jjb93l	421	41	salmon	salmon	NN
cord-334907-l4jjb93l	421	42	anemia	anemia	NN
cord-334907-l4jjb93l	421	43	virus	virus	NN
cord-334907-l4jjb93l	421	44	specifically	specifically	RB
cord-334907-l4jjb93l	421	45	binds	bind	VBZ
cord-334907-l4jjb93l	421	46	to	to	IN
cord-334907-l4jjb93l	421	47	and	and	CC
cord-334907-l4jjb93l	421	48	hydrolyzes	hydrolyze	VBZ
cord-334907-l4jjb93l	421	49	4-O	4-o	CD
cord-334907-l4jjb93l	421	50	-	-	HYPH
cord-334907-l4jjb93l	421	51	acetylated	acetylated	JJ
cord-334907-l4jjb93l	421	52	sialic	sialic	NN
cord-334907-l4jjb93l	421	53	acids	acid	NNS
cord-334907-l4jjb93l	422	1	The	the	DT
cord-334907-l4jjb93l	422	2	sialome	sialome	NN
cord-334907-l4jjb93l	422	3	-	-	HYPH
cord-334907-l4jjb93l	422	4	far	far	RB
cord-334907-l4jjb93l	422	5	more	more	JJR
cord-334907-l4jjb93l	422	6	than	than	IN
cord-334907-l4jjb93l	422	7	the	the	DT
cord-334907-l4jjb93l	422	8	sum	sum	NN
cord-334907-l4jjb93l	422	9	of	of	IN
cord-334907-l4jjb93l	422	10	its	-PRON-	PRP$
cord-334907-l4jjb93l	422	11	parts	part	NNS
cord-334907-l4jjb93l	422	12	Dual	dual	JJ
cord-334907-l4jjb93l	422	13	mutation	mutation	NN
cord-334907-l4jjb93l	422	14	events	event	NNS
cord-334907-l4jjb93l	422	15	in	in	IN
cord-334907-l4jjb93l	422	16	the	the	DT
cord-334907-l4jjb93l	422	17	haemagglutinin	haemagglutinin	JJ
cord-334907-l4jjb93l	422	18	-	-	HYPH
cord-334907-l4jjb93l	422	19	esterase	esterase	NN
cord-334907-l4jjb93l	422	20	and	and	CC
cord-334907-l4jjb93l	422	21	fusion	fusion	NN
cord-334907-l4jjb93l	422	22	protein	protein	NN
cord-334907-l4jjb93l	422	23	from	from	IN
cord-334907-l4jjb93l	422	24	an	an	DT
cord-334907-l4jjb93l	422	25	infectious	infectious	JJ
cord-334907-l4jjb93l	422	26	salmon	salmon	NN
cord-334907-l4jjb93l	422	27	anaemia	anaemia	NN
cord-334907-l4jjb93l	422	28	virus	virus	NN
cord-334907-l4jjb93l	422	29	HPR0	HPR0	NNP
cord-334907-l4jjb93l	422	30	genotype	genotype	NN
cord-334907-l4jjb93l	422	31	promote	promote	VBP
cord-334907-l4jjb93l	422	32	viral	viral	JJ
cord-334907-l4jjb93l	422	33	fusion	fusion	NN
cord-334907-l4jjb93l	422	34	and	and	CC
cord-334907-l4jjb93l	422	35	activation	activation	NN
cord-334907-l4jjb93l	422	36	by	by	IN
cord-334907-l4jjb93l	422	37	an	an	DT
cord-334907-l4jjb93l	422	38	ubiquitous	ubiquitous	JJ
cord-334907-l4jjb93l	422	39	host	host	NN
cord-334907-l4jjb93l	422	40	protease	protease	NN
cord-334907-l4jjb93l	422	41	Structural	structural	JJ
cord-334907-l4jjb93l	422	42	basis	basis	NN
cord-334907-l4jjb93l	422	43	for	for	IN
cord-334907-l4jjb93l	422	44	ligand	ligand	NN
cord-334907-l4jjb93l	422	45	and	and	CC
cord-334907-l4jjb93l	422	46	substrate	substrate	NN
cord-334907-l4jjb93l	422	47	recognition	recognition	NN
cord-334907-l4jjb93l	422	48	by	by	IN
cord-334907-l4jjb93l	422	49	torovirus	torovirus	NNP
cord-334907-l4jjb93l	422	50	hemagglutinin	hemagglutinin	NNP
cord-334907-l4jjb93l	422	51	esterases	esterases	NNP
cord-334907-l4jjb93l	423	1	The	the	DT
cord-334907-l4jjb93l	423	2	sweet	sweet	JJ
cord-334907-l4jjb93l	423	3	spot	spot	NN
cord-334907-l4jjb93l	423	4	:	:	:
cord-334907-l4jjb93l	424	1	Defining	define	VBG
cord-334907-l4jjb93l	424	2	virus	virus	NN
cord-334907-l4jjb93l	424	3	-	-	HYPH
cord-334907-l4jjb93l	424	4	sialic	sialic	NN
cord-334907-l4jjb93l	424	5	acid	acid	NN
cord-334907-l4jjb93l	424	6	interactions	interaction	NNS
cord-334907-l4jjb93l	424	7	Comparative	comparative	JJ
cord-334907-l4jjb93l	424	8	protein	protein	NN
cord-334907-l4jjb93l	424	9	structure	structure	NN
cord-334907-l4jjb93l	424	10	modeling	modeling	NN
cord-334907-l4jjb93l	424	11	using	use	VBG
cord-334907-l4jjb93l	424	12	Modeller	Modeller	NNP
cord-334907-l4jjb93l	424	13	Chemical	Chemical	NNP
cord-334907-l4jjb93l	424	14	synthesis	synthesis	NN
cord-334907-l4jjb93l	424	15	and	and	CC
cord-334907-l4jjb93l	424	16	in	in	IN
cord-334907-l4jjb93l	424	17	vitro	vitro	FW
cord-334907-l4jjb93l	424	18	evaluation	evaluation	NN
cord-334907-l4jjb93l	424	19	of	of	IN
cord-334907-l4jjb93l	424	20	a	a	DT
cord-334907-l4jjb93l	424	21	phage	phage	NN
cord-334907-l4jjb93l	424	22	display	display	NN
cord-334907-l4jjb93l	424	23	-	-	HYPH
cord-334907-l4jjb93l	424	24	derived	derive	VBN
cord-334907-l4jjb93l	424	25	peptide	peptide	NN
cord-334907-l4jjb93l	424	26	active	active	JJ
cord-334907-l4jjb93l	424	27	against	against	IN
cord-334907-l4jjb93l	424	28	infectious	infectious	JJ
cord-334907-l4jjb93l	424	29	salmon	salmon	NN
cord-334907-l4jjb93l	424	30	anemia	anemia	NN
cord-334907-l4jjb93l	424	31	virus	virus	NN
cord-334907-l4jjb93l	425	1	Influenza	Influenza	NNP
cord-334907-l4jjb93l	425	2	A	a	DT
cord-334907-l4jjb93l	425	3	virus	virus	NN
cord-334907-l4jjb93l	425	4	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	425	5	and	and	CC
cord-334907-l4jjb93l	425	6	neuraminidase	neuraminidase	RB
cord-334907-l4jjb93l	425	7	act	act	NNP
cord-334907-l4jjb93l	425	8	as	as	IN
cord-334907-l4jjb93l	425	9	novel	novel	JJ
cord-334907-l4jjb93l	425	10	motile	motile	JJ
cord-334907-l4jjb93l	425	11	machinery	machinery	NN
cord-334907-l4jjb93l	426	1	Influenza	influenza	NN
cord-334907-l4jjb93l	426	2	as	as	IN
cord-334907-l4jjb93l	426	3	a	a	DT
cord-334907-l4jjb93l	426	4	molecular	molecular	JJ
cord-334907-l4jjb93l	426	5	walker	walker	NNP
cord-334907-l4jjb93l	426	6	First	First	NNP
cord-334907-l4jjb93l	426	7	field	field	NN
cord-334907-l4jjb93l	426	8	evidence	evidence	NN
cord-334907-l4jjb93l	426	9	of	of	IN
cord-334907-l4jjb93l	426	10	the	the	DT
cord-334907-l4jjb93l	426	11	evolution	evolution	NN
cord-334907-l4jjb93l	426	12	from	from	IN
cord-334907-l4jjb93l	426	13	a	a	DT
cord-334907-l4jjb93l	426	14	non	non	JJ
cord-334907-l4jjb93l	426	15	-	-	JJ
cord-334907-l4jjb93l	426	16	virulent	virulent	JJ
cord-334907-l4jjb93l	426	17	HPR0	HPR0	NNP
cord-334907-l4jjb93l	426	18	to	to	IN
cord-334907-l4jjb93l	426	19	a	a	DT
cord-334907-l4jjb93l	426	20	virulent	virulent	JJ
cord-334907-l4jjb93l	426	21	HPR	HPR	NNP
cord-334907-l4jjb93l	426	22	-	-	HYPH
cord-334907-l4jjb93l	426	23	deleted	delete	VBN
cord-334907-l4jjb93l	426	24	infectious	infectious	JJ
cord-334907-l4jjb93l	426	25	salmon	salmon	NN
cord-334907-l4jjb93l	426	26	anaemia	anaemia	NN
cord-334907-l4jjb93l	426	27	virus	virus	NN
cord-334907-l4jjb93l	426	28	Structural	structural	JJ
cord-334907-l4jjb93l	426	29	and	and	CC
cord-334907-l4jjb93l	426	30	mechanistic	mechanistic	JJ
cord-334907-l4jjb93l	426	31	studies	study	NNS
cord-334907-l4jjb93l	426	32	of	of	IN
cord-334907-l4jjb93l	426	33	measles	measle	NNS
cord-334907-l4jjb93l	426	34	virus	virus	NN
cord-334907-l4jjb93l	426	35	illuminate	illuminate	VBP
cord-334907-l4jjb93l	426	36	paramyxovirus	paramyxovirus	JJ
cord-334907-l4jjb93l	426	37	entry	entry	NN
cord-334907-l4jjb93l	427	1	How	how	WRB
cord-334907-l4jjb93l	427	2	sticky	sticky	JJ
cord-334907-l4jjb93l	427	3	should	should	MD
cord-334907-l4jjb93l	427	4	a	a	DT
cord-334907-l4jjb93l	427	5	virus	virus	NN
cord-334907-l4jjb93l	427	6	be	be	VB
cord-334907-l4jjb93l	427	7	?	?	.
cord-334907-l4jjb93l	428	1	The	the	DT
cord-334907-l4jjb93l	428	2	impact	impact	NN
cord-334907-l4jjb93l	428	3	of	of	IN
cord-334907-l4jjb93l	428	4	virus	virus	NN
cord-334907-l4jjb93l	428	5	binding	binding	NN
cord-334907-l4jjb93l	428	6	and	and	CC
cord-334907-l4jjb93l	428	7	release	release	NN
cord-334907-l4jjb93l	428	8	on	on	IN
cord-334907-l4jjb93l	428	9	transmission	transmission	NN
cord-334907-l4jjb93l	428	10	fitness	fitness	NN
cord-334907-l4jjb93l	428	11	using	use	VBG
cord-334907-l4jjb93l	428	12	influenza	influenza	NN
cord-334907-l4jjb93l	428	13	as	as	IN
cord-334907-l4jjb93l	428	14	an	an	DT
cord-334907-l4jjb93l	428	15	example	example	NN
cord-334907-l4jjb93l	428	16	Structure	structure	NN
cord-334907-l4jjb93l	428	17	,	,	,
cord-334907-l4jjb93l	428	18	function	function	NN
cord-334907-l4jjb93l	428	19	and	and	CC
cord-334907-l4jjb93l	428	20	evolution	evolution	NN
cord-334907-l4jjb93l	428	21	of	of	IN
cord-334907-l4jjb93l	428	22	the	the	DT
cord-334907-l4jjb93l	428	23	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	428	24	-	-	HYPH
cord-334907-l4jjb93l	428	25	esterase	esterase	NN
cord-334907-l4jjb93l	428	26	proteins	protein	NNS
cord-334907-l4jjb93l	428	27	of	of	IN
cord-334907-l4jjb93l	428	28	corona	corona	NN
cord-334907-l4jjb93l	428	29	-	-	HYPH
cord-334907-l4jjb93l	428	30	and	and	CC
cord-334907-l4jjb93l	428	31	toroviruses	toroviruses	NNP
cord-334907-l4jjb93l	428	32	Structure	Structure	NNP
cord-334907-l4jjb93l	428	33	of	of	IN
cord-334907-l4jjb93l	428	34	coronavirus	coronavirus	NN
cord-334907-l4jjb93l	428	35	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	428	36	-	-	HYPH
cord-334907-l4jjb93l	428	37	esterase	esterase	NN
cord-334907-l4jjb93l	428	38	offers	offer	VBZ
cord-334907-l4jjb93l	428	39	insight	insight	NN
cord-334907-l4jjb93l	428	40	into	into	IN
cord-334907-l4jjb93l	428	41	corona	corona	NN
cord-334907-l4jjb93l	428	42	and	and	CC
cord-334907-l4jjb93l	428	43	influenza	influenza	NN
cord-334907-l4jjb93l	428	44	virus	virus	NN
cord-334907-l4jjb93l	428	45	evolution	evolution	NN
cord-334907-l4jjb93l	428	46	Binding	Binding	NNP
cord-334907-l4jjb93l	428	47	of	of	IN
cord-334907-l4jjb93l	428	48	influenza	influenza	NN
cord-334907-l4jjb93l	428	49	virus	virus	NN
cord-334907-l4jjb93l	428	50	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	428	51	to	to	IN
cord-334907-l4jjb93l	428	52	analogs	analog	NNS
cord-334907-l4jjb93l	428	53	of	of	IN
cord-334907-l4jjb93l	428	54	its	-PRON-	PRP$
cord-334907-l4jjb93l	428	55	cell	cell	NN
cord-334907-l4jjb93l	428	56	-	-	HYPH
cord-334907-l4jjb93l	428	57	surface	surface	NN
cord-334907-l4jjb93l	428	58	receptor	receptor	NN
cord-334907-l4jjb93l	428	59	,	,	,
cord-334907-l4jjb93l	428	60	sialic	sialic	JJ
cord-334907-l4jjb93l	428	61	acid	acid	NN
cord-334907-l4jjb93l	428	62	:	:	:
cord-334907-l4jjb93l	428	63	Analysis	analysis	NN
cord-334907-l4jjb93l	428	64	by	by	IN
cord-334907-l4jjb93l	428	65	proton	proton	NN
cord-334907-l4jjb93l	428	66	nuclear	nuclear	JJ
cord-334907-l4jjb93l	428	67	magnetic	magnetic	JJ
cord-334907-l4jjb93l	428	68	resonance	resonance	NN
cord-334907-l4jjb93l	428	69	spectroscopy	spectroscopy	NN
cord-334907-l4jjb93l	428	70	and	and	CC
cord-334907-l4jjb93l	428	71	X	x	NN
cord-334907-l4jjb93l	428	72	-	-	NN
cord-334907-l4jjb93l	428	73	ray	ray	NN
cord-334907-l4jjb93l	428	74	crystallography	crystallography	NN
cord-334907-l4jjb93l	428	75	Long	long	JJ
cord-334907-l4jjb93l	428	76	-	-	HYPH
cord-334907-l4jjb93l	428	77	range	range	NN
cord-334907-l4jjb93l	428	78	effects	effect	NNS
cord-334907-l4jjb93l	428	79	on	on	IN
cord-334907-l4jjb93l	428	80	the	the	DT
cord-334907-l4jjb93l	428	81	binding	binding	NN
cord-334907-l4jjb93l	428	82	of	of	IN
cord-334907-l4jjb93l	428	83	the	the	DT
cord-334907-l4jjb93l	428	84	influenza	influenza	NN
cord-334907-l4jjb93l	428	85	HA	HA	NNP
cord-334907-l4jjb93l	428	86	to	to	IN
cord-334907-l4jjb93l	428	87	receptors	receptor	NNS
cord-334907-l4jjb93l	428	88	are	be	VBP
cord-334907-l4jjb93l	428	89	mediated	mediate	VBN
cord-334907-l4jjb93l	428	90	by	by	IN
cord-334907-l4jjb93l	428	91	changes	change	NNS
cord-334907-l4jjb93l	428	92	in	in	IN
cord-334907-l4jjb93l	428	93	the	the	DT
cord-334907-l4jjb93l	428	94	stability	stability	NN
cord-334907-l4jjb93l	428	95	of	of	IN
cord-334907-l4jjb93l	428	96	a	a	DT
cord-334907-l4jjb93l	428	97	metastable	metastable	JJ
cord-334907-l4jjb93l	428	98	HA	HA	NNP
cord-334907-l4jjb93l	428	99	conformation	conformation	NN
cord-334907-l4jjb93l	428	100	Structure	structure	NN
cord-334907-l4jjb93l	428	101	of	of	IN
cord-334907-l4jjb93l	428	102	the	the	DT
cord-334907-l4jjb93l	428	103	haemagglutinin	haemagglutinin	JJ
cord-334907-l4jjb93l	428	104	-	-	HYPH
cord-334907-l4jjb93l	428	105	esterase	esterase	NN
cord-334907-l4jjb93l	428	106	-	-	HYPH
cord-334907-l4jjb93l	428	107	fusion	fusion	NN
cord-334907-l4jjb93l	428	108	glycoprotein	glycoprotein	NN
cord-334907-l4jjb93l	428	109	of	of	IN
cord-334907-l4jjb93l	428	110	influenza	influenza	NN
cord-334907-l4jjb93l	428	111	C	C	NNP
cord-334907-l4jjb93l	428	112	virus	virus	NN
cord-334907-l4jjb93l	428	113	Demonstration	demonstration	NN
cord-334907-l4jjb93l	428	114	of	of	IN
cord-334907-l4jjb93l	428	115	infectious	infectious	JJ
cord-334907-l4jjb93l	428	116	salmon	salmon	NN
cord-334907-l4jjb93l	428	117	anaemia	anaemia	NN
cord-334907-l4jjb93l	428	118	virus	virus	NN
cord-334907-l4jjb93l	428	119	(	(	-LRB-
cord-334907-l4jjb93l	428	120	ISAV	ISAV	NNP
cord-334907-l4jjb93l	428	121	)	)	-RRB-
cord-334907-l4jjb93l	428	122	endocytosis	endocytosis	NN
cord-334907-l4jjb93l	428	123	in	in	IN
cord-334907-l4jjb93l	428	124	erythrocytes	erythrocyte	NNS
cord-334907-l4jjb93l	428	125	of	of	IN
cord-334907-l4jjb93l	428	126	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	428	127	salmon	salmon	NN
cord-334907-l4jjb93l	428	128	Fish	fish	NN
cord-334907-l4jjb93l	428	129	red	red	JJ
cord-334907-l4jjb93l	428	130	blood	blood	NN
cord-334907-l4jjb93l	428	131	cells	cell	NNS
cord-334907-l4jjb93l	428	132	modulate	modulate	VBP
cord-334907-l4jjb93l	428	133	immune	immune	JJ
cord-334907-l4jjb93l	428	134	genes	gene	NNS
cord-334907-l4jjb93l	428	135	in	in	IN
cord-334907-l4jjb93l	428	136	response	response	NN
cord-334907-l4jjb93l	428	137	to	to	IN
cord-334907-l4jjb93l	428	138	bacterial	bacterial	JJ
cord-334907-l4jjb93l	428	139	inclusion	inclusion	NN
cord-334907-l4jjb93l	428	140	bodies	body	NNS
cord-334907-l4jjb93l	428	141	made	make	VBN
cord-334907-l4jjb93l	428	142	of	of	IN
cord-334907-l4jjb93l	428	143	TNFα	TNFα	NNS
cord-334907-l4jjb93l	428	144	and	and	CC
cord-334907-l4jjb93l	428	145	a	a	DT
cord-334907-l4jjb93l	428	146	g	g	NN
cord-334907-l4jjb93l	428	147	-	-	HYPH
cord-334907-l4jjb93l	428	148	VHSV	VHSV	NNP
cord-334907-l4jjb93l	428	149	fragment	fragment	NN
cord-334907-l4jjb93l	428	150	Piscine	piscine	FW
cord-334907-l4jjb93l	428	151	orthoreovirus	orthoreovirus	NN
cord-334907-l4jjb93l	428	152	(	(	-LRB-
cord-334907-l4jjb93l	428	153	PRV	PRV	NNP
cord-334907-l4jjb93l	428	154	)	)	-RRB-
cord-334907-l4jjb93l	428	155	infects	infect	VBZ
cord-334907-l4jjb93l	429	1	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	429	2	salmon	salmon	NN
cord-334907-l4jjb93l	429	3	erythrocytes	erythrocyte	VBZ
cord-334907-l4jjb93l	429	4	Piscine	Piscine	NNP
cord-334907-l4jjb93l	429	5	orthoreovirus	orthoreovirus	NN
cord-334907-l4jjb93l	429	6	(	(	-LRB-
cord-334907-l4jjb93l	429	7	PRV	prv	NN
cord-334907-l4jjb93l	429	8	)	)	-RRB-
cord-334907-l4jjb93l	430	1	replicates	replicate	NNS
cord-334907-l4jjb93l	430	2	in	in	IN
cord-334907-l4jjb93l	430	3	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	430	4	salmon	salmon	NN
cord-334907-l4jjb93l	431	1	(	(	-LRB-
cord-334907-l4jjb93l	431	2	Salmo	Salmo	NNP
cord-334907-l4jjb93l	431	3	salar	salar	NNP
cord-334907-l4jjb93l	431	4	L.	L.	NNP
cord-334907-l4jjb93l	431	5	)	)	-RRB-
cord-334907-l4jjb93l	431	6	erythrocytes	erythrocyte	VBZ
cord-334907-l4jjb93l	431	7	ex	ex	NN
cord-334907-l4jjb93l	431	8	vivo	vivo	NN
cord-334907-l4jjb93l	431	9	Combined	combine	VBN
cord-334907-l4jjb93l	431	10	use	use	NN
cord-334907-l4jjb93l	431	11	of	of	IN
cord-334907-l4jjb93l	431	12	the	the	DT
cord-334907-l4jjb93l	431	13	ASK	ask	NN
cord-334907-l4jjb93l	431	14	and	and	CC
cord-334907-l4jjb93l	431	15	SHK-1	SHK-1	NNP
cord-334907-l4jjb93l	431	16	cell	cell	NN
cord-334907-l4jjb93l	431	17	lines	line	NNS
cord-334907-l4jjb93l	431	18	to	to	TO
cord-334907-l4jjb93l	431	19	enhance	enhance	VB
cord-334907-l4jjb93l	431	20	the	the	DT
cord-334907-l4jjb93l	431	21	detection	detection	NN
cord-334907-l4jjb93l	431	22	of	of	IN
cord-334907-l4jjb93l	431	23	infectious	infectious	JJ
cord-334907-l4jjb93l	431	24	salmon	salmon	NN
cord-334907-l4jjb93l	431	25	anemia	anemia	NN
cord-334907-l4jjb93l	431	26	virus	virus	NN
cord-334907-l4jjb93l	431	27	Fish	fish	NN
cord-334907-l4jjb93l	431	28	cell	cell	NN
cord-334907-l4jjb93l	431	29	lines	line	NNS
cord-334907-l4jjb93l	431	30	:	:	:
cord-334907-l4jjb93l	432	1	Establishment	establishment	NN
cord-334907-l4jjb93l	432	2	and	and	CC
cord-334907-l4jjb93l	432	3	characterization	characterization	NN
cord-334907-l4jjb93l	432	4	of	of	IN
cord-334907-l4jjb93l	432	5	nine	nine	CD
cord-334907-l4jjb93l	432	6	cell	cell	NN
cord-334907-l4jjb93l	432	7	lines	line	NNS
cord-334907-l4jjb93l	432	8	from	from	IN
cord-334907-l4jjb93l	432	9	salmonids	salmonid	NNS
cord-334907-l4jjb93l	432	10	Development	Development	NNP
cord-334907-l4jjb93l	432	11	of	of	IN
cord-334907-l4jjb93l	432	12	plaque	plaque	NN
cord-334907-l4jjb93l	432	13	assay	assay	NN
cord-334907-l4jjb93l	432	14	for	for	IN
cord-334907-l4jjb93l	432	15	Chilean	Chilean	NNP
cord-334907-l4jjb93l	432	16	Infectious	Infectious	NNP
cord-334907-l4jjb93l	432	17	Salmon	Salmon	NNP
cord-334907-l4jjb93l	432	18	Anaemia	Anaemia	NNP
cord-334907-l4jjb93l	432	19	Virus	Virus	NNP
cord-334907-l4jjb93l	432	20	,	,	,
cord-334907-l4jjb93l	432	21	application	application	NN
cord-334907-l4jjb93l	432	22	for	for	IN
cord-334907-l4jjb93l	432	23	virus	virus	NN
cord-334907-l4jjb93l	432	24	purification	purification	NN
cord-334907-l4jjb93l	432	25	and	and	CC
cord-334907-l4jjb93l	432	26	titration	titration	NN
cord-334907-l4jjb93l	432	27	in	in	IN
cord-334907-l4jjb93l	432	28	salmon	salmon	NN
cord-334907-l4jjb93l	432	29	ASK	ask	VB
cord-334907-l4jjb93l	432	30	cells	cell	NNS
cord-334907-l4jjb93l	433	1	Influenza	Influenza	NNP
cord-334907-l4jjb93l	433	2	C	C	NNP
cord-334907-l4jjb93l	433	3	virus	virus	NN
cord-334907-l4jjb93l	433	4	esterase	esterase	NN
cord-334907-l4jjb93l	433	5	:	:	:
cord-334907-l4jjb93l	433	6	Analysis	analysis	NN
cord-334907-l4jjb93l	433	7	of	of	IN
cord-334907-l4jjb93l	433	8	catalytic	catalytic	JJ
cord-334907-l4jjb93l	433	9	site	site	NN
cord-334907-l4jjb93l	433	10	,	,	,
cord-334907-l4jjb93l	433	11	inhibition	inhibition	NN
cord-334907-l4jjb93l	433	12	,	,	,
cord-334907-l4jjb93l	433	13	and	and	CC
cord-334907-l4jjb93l	433	14	possible	possible	JJ
cord-334907-l4jjb93l	433	15	function	function	NN
cord-334907-l4jjb93l	433	16	Development	development	NN
cord-334907-l4jjb93l	433	17	,	,	,
cord-334907-l4jjb93l	433	18	application	application	NN
cord-334907-l4jjb93l	433	19	and	and	CC
cord-334907-l4jjb93l	433	20	validation	validation	NN
cord-334907-l4jjb93l	433	21	of	of	IN
cord-334907-l4jjb93l	433	22	a	a	DT
cord-334907-l4jjb93l	433	23	Taqman	Taqman	NNP
cord-334907-l4jjb93l	433	24	real	real	JJ
cord-334907-l4jjb93l	433	25	-	-	HYPH
cord-334907-l4jjb93l	433	26	time	time	NN
cord-334907-l4jjb93l	433	27	RT	RT	NNP
cord-334907-l4jjb93l	433	28	-	-	HYPH
cord-334907-l4jjb93l	433	29	PCR	PCR	NNP
cord-334907-l4jjb93l	433	30	assay	assay	NN
cord-334907-l4jjb93l	433	31	for	for	IN
cord-334907-l4jjb93l	433	32	the	the	DT
cord-334907-l4jjb93l	433	33	detection	detection	NN
cord-334907-l4jjb93l	433	34	of	of	IN
cord-334907-l4jjb93l	433	35	infectious	infectious	JJ
cord-334907-l4jjb93l	433	36	salmon	salmon	NN
cord-334907-l4jjb93l	433	37	anaemia	anaemia	NN
cord-334907-l4jjb93l	433	38	virus	virus	NN
cord-334907-l4jjb93l	433	39	(	(	-LRB-
cord-334907-l4jjb93l	433	40	ISAV	ISAV	NNP
cord-334907-l4jjb93l	433	41	)	)	-RRB-
cord-334907-l4jjb93l	433	42	in	in	IN
cord-334907-l4jjb93l	433	43	Atlantic	Atlantic	NNP
cord-334907-l4jjb93l	433	44	salmon	salmon	NN
cord-334907-l4jjb93l	434	1	(	(	-LRB-
cord-334907-l4jjb93l	434	2	Salmo	Salmo	NNP
cord-334907-l4jjb93l	434	3	salar	salar	NN
cord-334907-l4jjb93l	434	4	)	)	-RRB-
cord-334907-l4jjb93l	435	1	Characterization	characterization	NN
cord-334907-l4jjb93l	435	2	of	of	IN
cord-334907-l4jjb93l	435	3	salmon	salmon	NN
cord-334907-l4jjb93l	435	4	and	and	CC
cord-334907-l4jjb93l	435	5	trout	trout	NNS
cord-334907-l4jjb93l	435	6	CD8alpha	CD8alpha	NNP
cord-334907-l4jjb93l	435	7	and	and	CC
cord-334907-l4jjb93l	435	8	CD8beta	CD8beta	NNP
cord-334907-l4jjb93l	435	9	Analysis	Analysis	NNP
cord-334907-l4jjb93l	435	10	of	of	IN
cord-334907-l4jjb93l	435	11	relative	relative	JJ
cord-334907-l4jjb93l	435	12	gene	gene	NN
cord-334907-l4jjb93l	435	13	expression	expression	NN
cord-334907-l4jjb93l	435	14	data	datum	NNS
cord-334907-l4jjb93l	435	15	using	use	VBG
cord-334907-l4jjb93l	435	16	real	real	JJ
cord-334907-l4jjb93l	435	17	-	-	HYPH
cord-334907-l4jjb93l	435	18	time	time	NN
cord-334907-l4jjb93l	435	19	quantitative	quantitative	JJ
cord-334907-l4jjb93l	435	20	PCR	PCR	NNP
cord-334907-l4jjb93l	435	21	and	and	CC
cord-334907-l4jjb93l	435	22	the	the	DT
cord-334907-l4jjb93l	435	23	2(-Delta	2(-delta	CD
cord-334907-l4jjb93l	435	24	Delta	Delta	NNP
cord-334907-l4jjb93l	435	25	C(T	C(T	NNP
cord-334907-l4jjb93l	435	26	)	)	-RRB-
cord-334907-l4jjb93l	435	27	)	)	-RRB-
cord-334907-l4jjb93l	436	1	Method	method	NN
cord-334907-l4jjb93l	436	2	Scalable	scalable	JJ
cord-334907-l4jjb93l	436	3	web	web	NN
cord-334907-l4jjb93l	436	4	services	service	NNS
cord-334907-l4jjb93l	436	5	for	for	IN
cord-334907-l4jjb93l	436	6	the	the	DT
cord-334907-l4jjb93l	436	7	PSIPRED	PSIPRED	NNP
cord-334907-l4jjb93l	436	8	Protein	Protein	NNP
cord-334907-l4jjb93l	436	9	Analysis	Analysis	NNP
cord-334907-l4jjb93l	436	10	Workbench	Workbench	NNP
cord-334907-l4jjb93l	436	11	UCSF	UCSF	NNP
cord-334907-l4jjb93l	436	12	Chimera	Chimera	NNP
cord-334907-l4jjb93l	436	13	-	-	:
cord-334907-l4jjb93l	436	14	a	a	DT
cord-334907-l4jjb93l	436	15	visualization	visualization	NN
cord-334907-l4jjb93l	436	16	system	system	NN
cord-334907-l4jjb93l	436	17	for	for	IN
cord-334907-l4jjb93l	436	18	exploratory	exploratory	JJ
cord-334907-l4jjb93l	436	19	research	research	NN
cord-334907-l4jjb93l	436	20	and	and	CC
cord-334907-l4jjb93l	436	21	analysis	analysis	NN
cord-334907-l4jjb93l	437	1	Jalview	Jalview	NNP
cord-334907-l4jjb93l	437	2	Version	Version	NNP
cord-334907-l4jjb93l	438	1	2-a	2-a	CD
cord-334907-l4jjb93l	438	2	multiple	multiple	JJ
cord-334907-l4jjb93l	438	3	sequence	sequence	NN
cord-334907-l4jjb93l	438	4	alignment	alignment	NN
cord-334907-l4jjb93l	438	5	editor	editor	NN
cord-334907-l4jjb93l	438	6	and	and	CC
cord-334907-l4jjb93l	438	7	analysis	analysis	NN
cord-334907-l4jjb93l	438	8	workbench	workbench	NN
cord-334907-l4jjb93l	439	1	A	a	DT
cord-334907-l4jjb93l	439	2	general	general	JJ
cord-334907-l4jjb93l	439	3	method	method	NN
cord-334907-l4jjb93l	439	4	of	of	IN
cord-334907-l4jjb93l	439	5	in	in	FW
cord-334907-l4jjb93l	439	6	vitro	vitro	FW
cord-334907-l4jjb93l	439	7	preparation	preparation	NN
cord-334907-l4jjb93l	439	8	and	and	CC
cord-334907-l4jjb93l	439	9	specific	specific	JJ
cord-334907-l4jjb93l	439	10	mutagenesis	mutagenesis	NN
cord-334907-l4jjb93l	439	11	of	of	IN
cord-334907-l4jjb93l	439	12	DNA	dna	NN
cord-334907-l4jjb93l	439	13	fragments	fragment	NNS
cord-334907-l4jjb93l	439	14	:	:	:
cord-334907-l4jjb93l	439	15	Study	study	NN
cord-334907-l4jjb93l	439	16	of	of	IN
cord-334907-l4jjb93l	439	17	protein	protein	NN
cord-334907-l4jjb93l	439	18	and	and	CC
cord-334907-l4jjb93l	439	19	DNA	dna	NN
cord-334907-l4jjb93l	439	20	interactions	interaction	NNS
cord-334907-l4jjb93l	439	21	Loss	Loss	NNP
cord-334907-l4jjb93l	439	22	of	of	IN
cord-334907-l4jjb93l	439	23	human	human	JJ
cord-334907-l4jjb93l	439	24	Greatwall	Greatwall	NNP
cord-334907-l4jjb93l	439	25	results	result	VBZ
cord-334907-l4jjb93l	439	26	in	in	IN
cord-334907-l4jjb93l	439	27	G2	G2	NNP
cord-334907-l4jjb93l	439	28	arrest	arrest	NN
cord-334907-l4jjb93l	439	29	and	and	CC
cord-334907-l4jjb93l	439	30	multiple	multiple	JJ
cord-334907-l4jjb93l	439	31	mitotic	mitotic	JJ
cord-334907-l4jjb93l	439	32	defects	defect	NNS
cord-334907-l4jjb93l	439	33	due	due	IN
cord-334907-l4jjb93l	439	34	to	to	IN
cord-334907-l4jjb93l	439	35	deregulation	deregulation	NN
cord-334907-l4jjb93l	439	36	of	of	IN
cord-334907-l4jjb93l	439	37	the	the	DT
cord-334907-l4jjb93l	439	38	cyclin	cyclin	NN
cord-334907-l4jjb93l	439	39	B	B	NNP
cord-334907-l4jjb93l	439	40	-	-	HYPH
cord-334907-l4jjb93l	439	41	Cdc2	Cdc2	NNP
cord-334907-l4jjb93l	439	42	/	/	SYM
cord-334907-l4jjb93l	439	43	PP2A	PP2A	NNS
cord-334907-l4jjb93l	439	44	balance	balance	NN
cord-334907-l4jjb93l	439	45	Quantitative	quantitative	JJ
cord-334907-l4jjb93l	439	46	measurement	measurement	NN
cord-334907-l4jjb93l	439	47	of	of	IN
cord-334907-l4jjb93l	439	48	paramyxovirus	paramyxovirus	JJ
cord-334907-l4jjb93l	439	49	fusion	fusion	NN
cord-334907-l4jjb93l	439	50	:	:	:
cord-334907-l4jjb93l	439	51	Differences	difference	NNS
cord-334907-l4jjb93l	439	52	in	in	IN
cord-334907-l4jjb93l	439	53	requirements	requirement	NNS
cord-334907-l4jjb93l	439	54	of	of	IN
cord-334907-l4jjb93l	439	55	glycoproteins	glycoprotein	NNS
cord-334907-l4jjb93l	439	56	between	between	IN
cord-334907-l4jjb93l	439	57	simian	simian	JJ
cord-334907-l4jjb93l	439	58	virus	virus	NN
cord-334907-l4jjb93l	439	59	5	5	CD
cord-334907-l4jjb93l	439	60	and	and	CC
cord-334907-l4jjb93l	439	61	human	human	JJ
cord-334907-l4jjb93l	439	62	parainfluenza	parainfluenza	NNP
cord-334907-l4jjb93l	439	63	virus	virus	NNP
cord-334907-l4jjb93l	439	64	3	3	CD
cord-334907-l4jjb93l	439	65	or	or	CC
cord-334907-l4jjb93l	439	66	Newcastle	Newcastle	NNP
cord-334907-l4jjb93l	439	67	disease	disease	NN
cord-334907-l4jjb93l	439	68	virus	virus	NN
cord-334907-l4jjb93l	440	1	The	the	DT
cord-334907-l4jjb93l	440	2	pathway	pathway	NN
cord-334907-l4jjb93l	440	3	of	of	IN
cord-334907-l4jjb93l	440	4	membrane	membrane	NN
cord-334907-l4jjb93l	440	5	fusion	fusion	NN
cord-334907-l4jjb93l	440	6	catalyzed	catalyze	VBN
cord-334907-l4jjb93l	440	7	by	by	IN
cord-334907-l4jjb93l	440	8	influenza	influenza	NN
cord-334907-l4jjb93l	440	9	hemagglutinin	hemagglutinin	NN
cord-334907-l4jjb93l	440	10	:	:	:
cord-334907-l4jjb93l	440	11	Restriction	restriction	NN
cord-334907-l4jjb93l	440	12	of	of	IN
cord-334907-l4jjb93l	440	13	lipids	lipid	NNS
cord-334907-l4jjb93l	440	14	,	,	,
cord-334907-l4jjb93l	440	15	hemifusion	hemifusion	NN
cord-334907-l4jjb93l	440	16	,	,	,
cord-334907-l4jjb93l	440	17	and	and	CC
cord-334907-l4jjb93l	440	18	lipidic	lipidic	NNP
cord-334907-l4jjb93l	440	19	fusion	fusion	NN
cord-334907-l4jjb93l	440	20	pore	pore	NN
cord-334907-l4jjb93l	440	21	formation	formation	NN
cord-334907-l4jjb93l	441	1	This	this	DT
cord-334907-l4jjb93l	441	2	article	article	NN
cord-334907-l4jjb93l	441	3	is	be	VBZ
cord-334907-l4jjb93l	441	4	an	an	DT
cord-334907-l4jjb93l	441	5	open	open	JJ
cord-334907-l4jjb93l	441	6	access	access	NN
cord-334907-l4jjb93l	441	7	article	article	NN
cord-334907-l4jjb93l	441	8	distributed	distribute	VBN
cord-334907-l4jjb93l	441	9	under	under	IN
cord-334907-l4jjb93l	441	10	the	the	DT
cord-334907-l4jjb93l	441	11	terms	term	NNS
cord-334907-l4jjb93l	441	12	and	and	CC
cord-334907-l4jjb93l	441	13	conditions	condition	NNS
cord-334907-l4jjb93l	441	14	of	of	IN
cord-334907-l4jjb93l	441	15	the	the	DT
cord-334907-l4jjb93l	441	16	Creative	Creative	NNP
cord-334907-l4jjb93l	441	17	Commons	Commons	NNP
cord-334907-l4jjb93l	441	18	Attribution	Attribution	NNP
cord-334907-l4jjb93l	441	19	(	(	-LRB-
cord-334907-l4jjb93l	441	20	CC	CC	NNP
cord-334907-l4jjb93l	441	21	BY	by	IN
cord-334907-l4jjb93l	441	22	)	)	-RRB-
cord-334907-l4jjb93l	441	23	license	license	NN
cord-334907-l4jjb93l	442	1	The	the	DT
cord-334907-l4jjb93l	442	2	authors	author	NNS
cord-334907-l4jjb93l	442	3	declare	declare	VBP
cord-334907-l4jjb93l	442	4	no	no	DT
cord-334907-l4jjb93l	442	5	conflict	conflict	NN
cord-334907-l4jjb93l	442	6	of	of	IN
cord-334907-l4jjb93l	442	7	interest	interest	NN
cord-334907-l4jjb93l	442	8	.	.	.