id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002248-92pzqj35	Terasaki, Kaori	Mechanistic Insight into the Host Transcription Inhibition Function of Rift Valley Fever Virus NSs and Its Importance in Virulence	2016-10-06		.txt	text/plain	8436	382	52	Importantly, RVFV MP-12-NSs mutant viruses with an impaired general transcription inhibition function showed a reduced cytotoxicity in cell culture and attenuated virulence in young mice, compared with its parental virus MP-12, highlighting the contribution of NSs-mediated general transcription inhibition towards RVFV virulence. Each carried mutations in NSs that specifically targeted its general transcription inhibition function without affecting its ability to degrade PKR and inhibit IFN-β promoter induction, through its interaction with Sin3-associated protein 30, a part of the repressor complex at the IFN-β promoter. Importantly, RVFV MP-12-NSs mutant viruses with an impaired general transcription inhibition function showed a reduced cytotoxicity in cell culture and attenuated virulence in young mice, Both NSs mutants retained some NSs functions, including degradation of PKR and SAP30 binding, and yet these NSs mutants and wt NSs showed different levels of general transcriptional suppression activities in virus-infected cells.	./cache/cord-002248-92pzqj35.txt	./txt/cord-002248-92pzqj35.txt