id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002394-n85ptr5p	Reddy, Vijayalakshmi	Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations	2017-01-26		.txt	text/plain	6103	287	49	Therefore, in this study we investigated the possible occurrence of molecular mimicry between CHIKV E1 and host components using a three pronged strategy: (i) identification of homologous regions between CHIKV proteins and host tissue components using bioinformatics tools, (ii) establishing cross reactivity between serum samples obtained from CHIKV infected patients and peptides exhibiting molecular mimicry and (iii) validating the ability of the cross reactive peptides in inducing joint and muscle pathology in a mouse model. We investigated molecular mimicry in this study by using a combined approach of identifying homologous regions between CHIKV glycoprotein E1 protein and host tissue components using bioinformatics tools, the ability of these designed peptides to cross react with serum samples from CHIKV infected patients and inducing immune mediated joint and muscle pathology in a mouse model.	./cache/cord-002394-n85ptr5p.txt	./txt/cord-002394-n85ptr5p.txt