id	sid	tid	token	lemma	pos
cord-002248-92pzqj35	1	1	key	key	JJ
cord-002248-92pzqj35	1	2	:	:	:
cord-002248-92pzqj35	1	3	cord-002248	cord-002248	NNP
cord-002248-92pzqj35	1	4	-	-	HYPH
cord-002248-92pzqj35	1	5	92pzqj35	92pzqj35	CD
cord-002248-92pzqj35	1	6	authors	author	NNS
cord-002248-92pzqj35	1	7	:	:	:
cord-002248-92pzqj35	1	8	Terasaki	Terasaki	NNP
cord-002248-92pzqj35	1	9	,	,	,
cord-002248-92pzqj35	1	10	Kaori	Kaori	NNP
cord-002248-92pzqj35	1	11	;	;	:
cord-002248-92pzqj35	1	12	Ramirez	Ramirez	NNP
cord-002248-92pzqj35	1	13	,	,	,
cord-002248-92pzqj35	1	14	Sydney	Sydney	NNP
cord-002248-92pzqj35	1	15	I.	I.	NNP
cord-002248-92pzqj35	1	16	;	;	:
cord-002248-92pzqj35	1	17	Makino	Makino	NNP
cord-002248-92pzqj35	1	18	,	,	,
cord-002248-92pzqj35	2	1	Shinji	Shinji	NNP
cord-002248-92pzqj35	2	2	title	title	NN
cord-002248-92pzqj35	2	3	:	:	:
cord-002248-92pzqj35	3	1	Mechanistic	mechanistic	JJ
cord-002248-92pzqj35	3	2	Insight	Insight	NNP
cord-002248-92pzqj35	3	3	into	into	IN
cord-002248-92pzqj35	3	4	the	the	DT
cord-002248-92pzqj35	3	5	Host	Host	NNP
cord-002248-92pzqj35	3	6	Transcription	Transcription	NNP
cord-002248-92pzqj35	3	7	Inhibition	Inhibition	NNP
cord-002248-92pzqj35	3	8	Function	Function	NNP
cord-002248-92pzqj35	3	9	of	of	IN
cord-002248-92pzqj35	3	10	Rift	Rift	NNP
cord-002248-92pzqj35	3	11	Valley	Valley	NNP
cord-002248-92pzqj35	3	12	Fever	Fever	NNP
cord-002248-92pzqj35	3	13	Virus	Virus	NNP
cord-002248-92pzqj35	3	14	NSs	NSs	NNP
cord-002248-92pzqj35	3	15	and	and	CC
cord-002248-92pzqj35	3	16	Its	-PRON-	PRP$
cord-002248-92pzqj35	3	17	Importance	importance	NN
cord-002248-92pzqj35	3	18	in	in	IN
cord-002248-92pzqj35	3	19	Virulence	Virulence	NNP
cord-002248-92pzqj35	3	20	date	date	NN
cord-002248-92pzqj35	3	21	:	:	:
cord-002248-92pzqj35	3	22	2016	2016	CD
cord-002248-92pzqj35	3	23	-	-	SYM
cord-002248-92pzqj35	3	24	10	10	CD
cord-002248-92pzqj35	3	25	-	-	HYPH
cord-002248-92pzqj35	3	26	06	06	CD
cord-002248-92pzqj35	3	27	journal	journal	NN
cord-002248-92pzqj35	3	28	:	:	:
cord-002248-92pzqj35	4	1	PLoS	PLoS	NNP
cord-002248-92pzqj35	4	2	Negl	Negl	NNP
cord-002248-92pzqj35	4	3	Trop	Trop	NNP
cord-002248-92pzqj35	4	4	Dis	dis	NN
cord-002248-92pzqj35	4	5	DOI	doi	NN
cord-002248-92pzqj35	4	6	:	:	:
cord-002248-92pzqj35	5	1	10.1371	10.1371	CD
cord-002248-92pzqj35	5	2	/	/	SYM
cord-002248-92pzqj35	5	3	journal.pntd.0005047	journal.pntd.0005047	NNP
cord-002248-92pzqj35	5	4	sha	sha	NNP
cord-002248-92pzqj35	5	5	:	:	:
cord-002248-92pzqj35	5	6	acf54b736dacc46a77d7f071f9c0cb9c14b2fc19	acf54b736dacc46a77d7f071f9c0cb9c14b2fc19	NNP
cord-002248-92pzqj35	5	7	doc_id	doc_id	NNP
cord-002248-92pzqj35	5	8	:	:	:
cord-002248-92pzqj35	5	9	2248	2248	CD
cord-002248-92pzqj35	5	10	cord_uid	cord_uid	NN
cord-002248-92pzqj35	5	11	:	:	:
cord-002248-92pzqj35	6	1	92pzqj35	92pzqj35	CD
cord-002248-92pzqj35	6	2	Rift	Rift	NNP
cord-002248-92pzqj35	6	3	Valley	Valley	NNP
cord-002248-92pzqj35	6	4	fever	fever	NN
cord-002248-92pzqj35	6	5	virus	virus	NN
cord-002248-92pzqj35	6	6	(	(	-LRB-
cord-002248-92pzqj35	6	7	RVFV	RVFV	NNP
cord-002248-92pzqj35	6	8	)	)	-RRB-
cord-002248-92pzqj35	6	9	,	,	,
cord-002248-92pzqj35	6	10	a	a	DT
cord-002248-92pzqj35	6	11	member	member	NN
cord-002248-92pzqj35	6	12	of	of	IN
cord-002248-92pzqj35	6	13	the	the	DT
cord-002248-92pzqj35	6	14	genus	genus	NN
cord-002248-92pzqj35	6	15	Phlebovirus	Phlebovirus	NNP
cord-002248-92pzqj35	6	16	within	within	IN
cord-002248-92pzqj35	6	17	the	the	DT
cord-002248-92pzqj35	6	18	family	family	NN
cord-002248-92pzqj35	6	19	Bunyaviridae	Bunyaviridae	NNP
cord-002248-92pzqj35	6	20	,	,	,
cord-002248-92pzqj35	6	21	causes	cause	VBZ
cord-002248-92pzqj35	6	22	periodic	periodic	JJ
cord-002248-92pzqj35	6	23	outbreaks	outbreak	NNS
cord-002248-92pzqj35	6	24	in	in	IN
cord-002248-92pzqj35	6	25	livestocks	livestock	NNS
cord-002248-92pzqj35	6	26	and	and	CC
cord-002248-92pzqj35	6	27	humans	human	NNS
cord-002248-92pzqj35	6	28	in	in	IN
cord-002248-92pzqj35	6	29	countries	country	NNS
cord-002248-92pzqj35	6	30	of	of	IN
cord-002248-92pzqj35	6	31	the	the	DT
cord-002248-92pzqj35	6	32	African	african	JJ
cord-002248-92pzqj35	6	33	continent	continent	NN
cord-002248-92pzqj35	6	34	and	and	CC
cord-002248-92pzqj35	6	35	Middle	Middle	NNP
cord-002248-92pzqj35	6	36	East	East	NNP
cord-002248-92pzqj35	6	37	.	.	.
cord-002248-92pzqj35	7	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	7	2	NSs	NSs	NNP
cord-002248-92pzqj35	7	3	protein	protein	NN
cord-002248-92pzqj35	7	4	,	,	,
cord-002248-92pzqj35	7	5	a	a	DT
cord-002248-92pzqj35	7	6	nonstructural	nonstructural	JJ
cord-002248-92pzqj35	7	7	protein	protein	NN
cord-002248-92pzqj35	7	8	,	,	,
cord-002248-92pzqj35	7	9	is	be	VBZ
cord-002248-92pzqj35	7	10	a	a	DT
cord-002248-92pzqj35	7	11	major	major	JJ
cord-002248-92pzqj35	7	12	virulence	virulence	NN
cord-002248-92pzqj35	7	13	factor	factor	NN
cord-002248-92pzqj35	7	14	that	that	WDT
cord-002248-92pzqj35	7	15	exhibits	exhibit	VBZ
cord-002248-92pzqj35	7	16	several	several	JJ
cord-002248-92pzqj35	7	17	important	important	JJ
cord-002248-92pzqj35	7	18	biological	biological	JJ
cord-002248-92pzqj35	7	19	properties	property	NNS
cord-002248-92pzqj35	7	20	.	.	.
cord-002248-92pzqj35	8	1	These	these	DT
cord-002248-92pzqj35	8	2	include	include	VBP
cord-002248-92pzqj35	8	3	suppression	suppression	NN
cord-002248-92pzqj35	8	4	of	of	IN
cord-002248-92pzqj35	8	5	general	general	JJ
cord-002248-92pzqj35	8	6	transcription	transcription	NN
cord-002248-92pzqj35	8	7	,	,	,
cord-002248-92pzqj35	8	8	inhibition	inhibition	NN
cord-002248-92pzqj35	8	9	of	of	IN
cord-002248-92pzqj35	8	10	IFN	IFN	NNP
cord-002248-92pzqj35	8	11	-	-	HYPH
cord-002248-92pzqj35	8	12	β	β	NNP
cord-002248-92pzqj35	8	13	promoter	promoter	NN
cord-002248-92pzqj35	8	14	induction	induction	NN
cord-002248-92pzqj35	8	15	and	and	CC
cord-002248-92pzqj35	8	16	degradation	degradation	NN
cord-002248-92pzqj35	8	17	of	of	IN
cord-002248-92pzqj35	8	18	double	double	RB
cord-002248-92pzqj35	8	19	-	-	HYPH
cord-002248-92pzqj35	8	20	stranded	strand	VBN
cord-002248-92pzqj35	8	21	RNA	rna	NN
cord-002248-92pzqj35	8	22	-	-	HYPH
cord-002248-92pzqj35	8	23	dependent	dependent	JJ
cord-002248-92pzqj35	8	24	protein	protein	NN
cord-002248-92pzqj35	8	25	kinase	kinase	NN
cord-002248-92pzqj35	8	26	R.	R.	NNP
cord-002248-92pzqj35	9	1	Although	although	IN
cord-002248-92pzqj35	9	2	each	each	DT
cord-002248-92pzqj35	9	3	of	of	IN
cord-002248-92pzqj35	9	4	these	these	DT
cord-002248-92pzqj35	9	5	biological	biological	JJ
cord-002248-92pzqj35	9	6	functions	function	NNS
cord-002248-92pzqj35	9	7	of	of	IN
cord-002248-92pzqj35	9	8	NSs	ns	NNS
cord-002248-92pzqj35	9	9	are	be	VBP
cord-002248-92pzqj35	9	10	considered	consider	VBN
cord-002248-92pzqj35	9	11	important	important	JJ
cord-002248-92pzqj35	9	12	for	for	IN
cord-002248-92pzqj35	9	13	countering	counter	VBG
cord-002248-92pzqj35	9	14	the	the	DT
cord-002248-92pzqj35	9	15	antiviral	antiviral	JJ
cord-002248-92pzqj35	9	16	response	response	NN
cord-002248-92pzqj35	9	17	in	in	IN
cord-002248-92pzqj35	9	18	the	the	DT
cord-002248-92pzqj35	9	19	host	host	NN
cord-002248-92pzqj35	9	20	,	,	,
cord-002248-92pzqj35	9	21	the	the	DT
cord-002248-92pzqj35	9	22	individual	individual	JJ
cord-002248-92pzqj35	9	23	contributions	contribution	NNS
cord-002248-92pzqj35	9	24	of	of	IN
cord-002248-92pzqj35	9	25	these	these	DT
cord-002248-92pzqj35	9	26	functions	function	NNS
cord-002248-92pzqj35	9	27	towards	towards	IN
cord-002248-92pzqj35	9	28	RVFV	RVFV	NNP
cord-002248-92pzqj35	9	29	virulence	virulence	NN
cord-002248-92pzqj35	9	30	remains	remain	VBZ
cord-002248-92pzqj35	9	31	unclear	unclear	JJ
cord-002248-92pzqj35	9	32	.	.	.
cord-002248-92pzqj35	10	1	To	to	TO
cord-002248-92pzqj35	10	2	examine	examine	VB
cord-002248-92pzqj35	10	3	this	this	DT
cord-002248-92pzqj35	10	4	,	,	,
cord-002248-92pzqj35	10	5	we	-PRON-	PRP
cord-002248-92pzqj35	10	6	generated	generate	VBD
cord-002248-92pzqj35	10	7	two	two	CD
cord-002248-92pzqj35	10	8	RVFV	RVFV	NNP
cord-002248-92pzqj35	10	9	MP-12	MP-12	NNP
cord-002248-92pzqj35	10	10	strain	strain	NN
cord-002248-92pzqj35	10	11	-	-	HYPH
cord-002248-92pzqj35	10	12	derived	derive	VBN
cord-002248-92pzqj35	10	13	mutant	mutant	JJ
cord-002248-92pzqj35	10	14	viruses	virus	NNS
cord-002248-92pzqj35	10	15	.	.	.
cord-002248-92pzqj35	11	1	Each	each	DT
cord-002248-92pzqj35	11	2	carried	carry	VBN
cord-002248-92pzqj35	11	3	mutations	mutation	NNS
cord-002248-92pzqj35	11	4	in	in	IN
cord-002248-92pzqj35	11	5	NSs	ns	NNS
cord-002248-92pzqj35	11	6	that	that	WDT
cord-002248-92pzqj35	11	7	specifically	specifically	RB
cord-002248-92pzqj35	11	8	targeted	target	VBD
cord-002248-92pzqj35	11	9	its	-PRON-	PRP$
cord-002248-92pzqj35	11	10	general	general	JJ
cord-002248-92pzqj35	11	11	transcription	transcription	NN
cord-002248-92pzqj35	11	12	inhibition	inhibition	NN
cord-002248-92pzqj35	11	13	function	function	NN
cord-002248-92pzqj35	11	14	without	without	IN
cord-002248-92pzqj35	11	15	affecting	affect	VBG
cord-002248-92pzqj35	11	16	its	-PRON-	PRP$
cord-002248-92pzqj35	11	17	ability	ability	NN
cord-002248-92pzqj35	11	18	to	to	TO
cord-002248-92pzqj35	11	19	degrade	degrade	VB
cord-002248-92pzqj35	11	20	PKR	PKR	NNP
cord-002248-92pzqj35	11	21	and	and	CC
cord-002248-92pzqj35	11	22	inhibit	inhibit	VB
cord-002248-92pzqj35	11	23	IFN	IFN	NNP
cord-002248-92pzqj35	11	24	-	-	HYPH
cord-002248-92pzqj35	11	25	β	β	NNP
cord-002248-92pzqj35	11	26	promoter	promoter	NN
cord-002248-92pzqj35	11	27	induction	induction	NN
cord-002248-92pzqj35	11	28	,	,	,
cord-002248-92pzqj35	11	29	through	through	IN
cord-002248-92pzqj35	11	30	its	-PRON-	PRP$
cord-002248-92pzqj35	11	31	interaction	interaction	NN
cord-002248-92pzqj35	11	32	with	with	IN
cord-002248-92pzqj35	11	33	Sin3-associated	sin3-associate	VBN
cord-002248-92pzqj35	11	34	protein	protein	NNP
cord-002248-92pzqj35	11	35	30	30	CD
cord-002248-92pzqj35	11	36	,	,	,
cord-002248-92pzqj35	11	37	a	a	DT
cord-002248-92pzqj35	11	38	part	part	NN
cord-002248-92pzqj35	11	39	of	of	IN
cord-002248-92pzqj35	11	40	the	the	DT
cord-002248-92pzqj35	11	41	repressor	repressor	NN
cord-002248-92pzqj35	11	42	complex	complex	NN
cord-002248-92pzqj35	11	43	at	at	IN
cord-002248-92pzqj35	11	44	the	the	DT
cord-002248-92pzqj35	11	45	IFN	IFN	NNP
cord-002248-92pzqj35	11	46	-	-	HYPH
cord-002248-92pzqj35	11	47	β	β	NNP
cord-002248-92pzqj35	11	48	promoter	promoter	NN
cord-002248-92pzqj35	11	49	.	.	.
cord-002248-92pzqj35	12	1	Using	use	VBG
cord-002248-92pzqj35	12	2	these	these	DT
cord-002248-92pzqj35	12	3	mutant	mutant	JJ
cord-002248-92pzqj35	12	4	viruses	virus	NNS
cord-002248-92pzqj35	12	5	,	,	,
cord-002248-92pzqj35	12	6	we	-PRON-	PRP
cord-002248-92pzqj35	12	7	have	have	VBP
cord-002248-92pzqj35	12	8	dissected	dissect	VBN
cord-002248-92pzqj35	12	9	the	the	DT
cord-002248-92pzqj35	12	10	transcription	transcription	NN
cord-002248-92pzqj35	12	11	inhibition	inhibition	NN
cord-002248-92pzqj35	12	12	function	function	NN
cord-002248-92pzqj35	12	13	of	of	IN
cord-002248-92pzqj35	12	14	NSs	ns	NNS
cord-002248-92pzqj35	12	15	and	and	CC
cord-002248-92pzqj35	12	16	examined	examine	VBD
cord-002248-92pzqj35	12	17	its	-PRON-	PRP$
cord-002248-92pzqj35	12	18	importance	importance	NN
cord-002248-92pzqj35	12	19	in	in	IN
cord-002248-92pzqj35	12	20	RVFV	RVFV	NNP
cord-002248-92pzqj35	12	21	virulence	virulence	NN
cord-002248-92pzqj35	12	22	.	.	.
cord-002248-92pzqj35	13	1	Both	both	DT
cord-002248-92pzqj35	13	2	NSs	NSs	NNP
cord-002248-92pzqj35	13	3	mutant	mutant	NN
cord-002248-92pzqj35	13	4	viruses	virus	NNS
cord-002248-92pzqj35	13	5	exhibited	exhibit	VBD
cord-002248-92pzqj35	13	6	a	a	DT
cord-002248-92pzqj35	13	7	differentially	differentially	RB
cord-002248-92pzqj35	13	8	impaired	impair	VBN
cord-002248-92pzqj35	13	9	ability	ability	NN
cord-002248-92pzqj35	13	10	to	to	TO
cord-002248-92pzqj35	13	11	inhibit	inhibit	VB
cord-002248-92pzqj35	13	12	host	host	NN
cord-002248-92pzqj35	13	13	transcription	transcription	NN
cord-002248-92pzqj35	13	14	when	when	WRB
cord-002248-92pzqj35	13	15	compared	compare	VBN
cord-002248-92pzqj35	13	16	with	with	IN
cord-002248-92pzqj35	13	17	MP-12	MP-12	NNP
cord-002248-92pzqj35	13	18	.	.	.
cord-002248-92pzqj35	14	1	It	-PRON-	PRP
cord-002248-92pzqj35	14	2	has	have	VBZ
cord-002248-92pzqj35	14	3	been	be	VBN
cord-002248-92pzqj35	14	4	reported	report	VBN
cord-002248-92pzqj35	14	5	that	that	IN
cord-002248-92pzqj35	14	6	NSs	NSs	NNP
cord-002248-92pzqj35	14	7	suppresses	suppress	VBZ
cord-002248-92pzqj35	14	8	general	general	JJ
cord-002248-92pzqj35	14	9	transcription	transcription	NN
cord-002248-92pzqj35	14	10	by	by	IN
cord-002248-92pzqj35	14	11	interfering	interfere	VBG
cord-002248-92pzqj35	14	12	with	with	IN
cord-002248-92pzqj35	14	13	the	the	DT
cord-002248-92pzqj35	14	14	formation	formation	NN
cord-002248-92pzqj35	14	15	of	of	IN
cord-002248-92pzqj35	14	16	the	the	DT
cord-002248-92pzqj35	14	17	transcription	transcription	NN
cord-002248-92pzqj35	14	18	factor	factor	NN
cord-002248-92pzqj35	14	19	IIH	IIH	NNP
cord-002248-92pzqj35	14	20	complex	complex	NN
cord-002248-92pzqj35	14	21	,	,	,
cord-002248-92pzqj35	14	22	through	through	IN
cord-002248-92pzqj35	14	23	the	the	DT
cord-002248-92pzqj35	14	24	degradation	degradation	NN
cord-002248-92pzqj35	14	25	of	of	IN
cord-002248-92pzqj35	14	26	the	the	DT
cord-002248-92pzqj35	14	27	p62	p62	NN
cord-002248-92pzqj35	14	28	subunit	subunit	NN
cord-002248-92pzqj35	14	29	and	and	CC
cord-002248-92pzqj35	14	30	sequestration	sequestration	NN
cord-002248-92pzqj35	14	31	of	of	IN
cord-002248-92pzqj35	14	32	the	the	DT
cord-002248-92pzqj35	14	33	p44	p44	NN
cord-002248-92pzqj35	14	34	subunit	subunit	NN
cord-002248-92pzqj35	14	35	.	.	.
cord-002248-92pzqj35	15	1	Our	-PRON-	PRP$
cord-002248-92pzqj35	15	2	study	study	NN
cord-002248-92pzqj35	15	3	results	result	NNS
cord-002248-92pzqj35	15	4	lead	lead	VBP
cord-002248-92pzqj35	15	5	us	-PRON-	PRP
cord-002248-92pzqj35	15	6	to	to	TO
cord-002248-92pzqj35	15	7	suggest	suggest	VB
cord-002248-92pzqj35	15	8	that	that	IN
cord-002248-92pzqj35	15	9	the	the	DT
cord-002248-92pzqj35	15	10	ability	ability	NN
cord-002248-92pzqj35	15	11	of	of	IN
cord-002248-92pzqj35	15	12	NSs	ns	NNS
cord-002248-92pzqj35	15	13	to	to	TO
cord-002248-92pzqj35	15	14	induce	induce	VB
cord-002248-92pzqj35	15	15	p62	p62	NN
cord-002248-92pzqj35	15	16	degradation	degradation	NN
cord-002248-92pzqj35	15	17	is	be	VBZ
cord-002248-92pzqj35	15	18	the	the	DT
cord-002248-92pzqj35	15	19	major	major	JJ
cord-002248-92pzqj35	15	20	contributor	contributor	NN
cord-002248-92pzqj35	15	21	to	to	IN
cord-002248-92pzqj35	15	22	its	-PRON-	PRP$
cord-002248-92pzqj35	15	23	general	general	JJ
cord-002248-92pzqj35	15	24	transcription	transcription	NN
cord-002248-92pzqj35	15	25	inhibition	inhibition	NN
cord-002248-92pzqj35	15	26	property	property	NN
cord-002248-92pzqj35	15	27	,	,	,
cord-002248-92pzqj35	15	28	whereas	whereas	IN
cord-002248-92pzqj35	15	29	its	-PRON-	PRP$
cord-002248-92pzqj35	15	30	interaction	interaction	NN
cord-002248-92pzqj35	15	31	with	with	IN
cord-002248-92pzqj35	15	32	p44	p44	CD
cord-002248-92pzqj35	15	33	may	may	MD
cord-002248-92pzqj35	15	34	not	not	RB
cord-002248-92pzqj35	15	35	play	play	VB
cord-002248-92pzqj35	15	36	a	a	DT
cord-002248-92pzqj35	15	37	significant	significant	JJ
cord-002248-92pzqj35	15	38	role	role	NN
cord-002248-92pzqj35	15	39	in	in	IN
cord-002248-92pzqj35	15	40	this	this	DT
cord-002248-92pzqj35	15	41	function	function	NN
cord-002248-92pzqj35	15	42	.	.	.
cord-002248-92pzqj35	16	1	Importantly	importantly	RB
cord-002248-92pzqj35	16	2	,	,	,
cord-002248-92pzqj35	16	3	RVFV	RVFV	NNP
cord-002248-92pzqj35	16	4	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	16	5	mutant	mutant	JJ
cord-002248-92pzqj35	16	6	viruses	virus	NNS
cord-002248-92pzqj35	16	7	with	with	IN
cord-002248-92pzqj35	16	8	an	an	DT
cord-002248-92pzqj35	16	9	impaired	impaired	JJ
cord-002248-92pzqj35	16	10	general	general	JJ
cord-002248-92pzqj35	16	11	transcription	transcription	NN
cord-002248-92pzqj35	16	12	inhibition	inhibition	NN
cord-002248-92pzqj35	16	13	function	function	NN
cord-002248-92pzqj35	16	14	showed	show	VBD
cord-002248-92pzqj35	16	15	a	a	DT
cord-002248-92pzqj35	16	16	reduced	reduce	VBN
cord-002248-92pzqj35	16	17	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	16	18	in	in	IN
cord-002248-92pzqj35	16	19	cell	cell	NN
cord-002248-92pzqj35	16	20	culture	culture	NN
cord-002248-92pzqj35	16	21	and	and	CC
cord-002248-92pzqj35	16	22	attenuated	attenuated	JJ
cord-002248-92pzqj35	16	23	virulence	virulence	NN
cord-002248-92pzqj35	16	24	in	in	IN
cord-002248-92pzqj35	16	25	young	young	JJ
cord-002248-92pzqj35	16	26	mice	mouse	NNS
cord-002248-92pzqj35	16	27	,	,	,
cord-002248-92pzqj35	16	28	compared	compare	VBN
cord-002248-92pzqj35	16	29	with	with	IN
cord-002248-92pzqj35	16	30	its	-PRON-	PRP$
cord-002248-92pzqj35	16	31	parental	parental	JJ
cord-002248-92pzqj35	16	32	virus	virus	NN
cord-002248-92pzqj35	16	33	MP-12	MP-12	NNP
cord-002248-92pzqj35	16	34	,	,	,
cord-002248-92pzqj35	16	35	highlighting	highlight	VBG
cord-002248-92pzqj35	16	36	the	the	DT
cord-002248-92pzqj35	16	37	contribution	contribution	NN
cord-002248-92pzqj35	16	38	of	of	IN
cord-002248-92pzqj35	16	39	NSs	NSs	NNP
cord-002248-92pzqj35	16	40	-	-	HYPH
cord-002248-92pzqj35	16	41	mediated	mediate	VBN
cord-002248-92pzqj35	16	42	general	general	JJ
cord-002248-92pzqj35	16	43	transcription	transcription	NN
cord-002248-92pzqj35	16	44	inhibition	inhibition	NN
cord-002248-92pzqj35	16	45	towards	towards	IN
cord-002248-92pzqj35	16	46	RVFV	RVFV	NNP
cord-002248-92pzqj35	16	47	virulence	virulence	NN
cord-002248-92pzqj35	16	48	.	.	.
cord-002248-92pzqj35	17	1	Rift	Rift	NNP
cord-002248-92pzqj35	17	2	Valley	Valley	NNP
cord-002248-92pzqj35	17	3	fever	fever	NN
cord-002248-92pzqj35	17	4	virus	virus	NN
cord-002248-92pzqj35	17	5	(	(	-LRB-
cord-002248-92pzqj35	17	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	17	7	)	)	-RRB-
cord-002248-92pzqj35	17	8	,	,	,
cord-002248-92pzqj35	17	9	a	a	DT
cord-002248-92pzqj35	17	10	member	member	NN
cord-002248-92pzqj35	17	11	of	of	IN
cord-002248-92pzqj35	17	12	the	the	DT
cord-002248-92pzqj35	17	13	genus	genus	NN
cord-002248-92pzqj35	17	14	Phlebovirus	Phlebovirus	NNP
cord-002248-92pzqj35	17	15	within	within	IN
cord-002248-92pzqj35	17	16	the	the	DT
cord-002248-92pzqj35	17	17	family	family	NN
cord-002248-92pzqj35	17	18	Bunyaviridae	Bunyaviridae	NNP
cord-002248-92pzqj35	17	19	,	,	,
cord-002248-92pzqj35	17	20	causes	cause	VBZ
cord-002248-92pzqj35	17	21	periodic	periodic	JJ
cord-002248-92pzqj35	17	22	outbreaks	outbreak	NNS
cord-002248-92pzqj35	17	23	in	in	IN
cord-002248-92pzqj35	17	24	livestocks	livestock	NNS
cord-002248-92pzqj35	17	25	and	and	CC
cord-002248-92pzqj35	17	26	humans	human	NNS
cord-002248-92pzqj35	17	27	in	in	IN
cord-002248-92pzqj35	17	28	countries	country	NNS
cord-002248-92pzqj35	17	29	of	of	IN
cord-002248-92pzqj35	17	30	the	the	DT
cord-002248-92pzqj35	17	31	African	african	JJ
cord-002248-92pzqj35	17	32	continent	continent	NN
cord-002248-92pzqj35	17	33	and	and	CC
cord-002248-92pzqj35	17	34	Middle	Middle	NNP
cord-002248-92pzqj35	17	35	East	East	NNP
cord-002248-92pzqj35	17	36	.	.	.
cord-002248-92pzqj35	18	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	18	2	NSs	NSs	NNP
cord-002248-92pzqj35	18	3	protein	protein	NN
cord-002248-92pzqj35	18	4	,	,	,
cord-002248-92pzqj35	18	5	a	a	DT
cord-002248-92pzqj35	18	6	nonstructural	nonstructural	JJ
cord-002248-92pzqj35	18	7	protein	protein	NN
cord-002248-92pzqj35	18	8	,	,	,
cord-002248-92pzqj35	18	9	is	be	VBZ
cord-002248-92pzqj35	18	10	a	a	DT
cord-002248-92pzqj35	18	11	major	major	JJ
cord-002248-92pzqj35	18	12	virulence	virulence	NN
cord-002248-92pzqj35	18	13	factor	factor	NN
cord-002248-92pzqj35	18	14	that	that	WDT
cord-002248-92pzqj35	18	15	exhibits	exhibit	VBZ
cord-002248-92pzqj35	18	16	several	several	JJ
cord-002248-92pzqj35	18	17	important	important	JJ
cord-002248-92pzqj35	18	18	biological	biological	JJ
cord-002248-92pzqj35	18	19	properties	property	NNS
cord-002248-92pzqj35	18	20	.	.	.
cord-002248-92pzqj35	19	1	These	these	DT
cord-002248-92pzqj35	19	2	include	include	VBP
cord-002248-92pzqj35	19	3	suppression	suppression	NN
cord-002248-92pzqj35	19	4	of	of	IN
cord-002248-92pzqj35	19	5	general	general	JJ
cord-002248-92pzqj35	19	6	transcription	transcription	NN
cord-002248-92pzqj35	19	7	,	,	,
cord-002248-92pzqj35	19	8	inhibition	inhibition	NN
cord-002248-92pzqj35	19	9	of	of	IN
cord-002248-92pzqj35	19	10	IFN	IFN	NNP
cord-002248-92pzqj35	19	11	-	-	HYPH
cord-002248-92pzqj35	19	12	β	β	NNP
cord-002248-92pzqj35	19	13	promoter	promoter	NN
cord-002248-92pzqj35	19	14	induction	induction	NN
cord-002248-92pzqj35	19	15	and	and	CC
cord-002248-92pzqj35	19	16	degradation	degradation	NN
cord-002248-92pzqj35	19	17	of	of	IN
cord-002248-92pzqj35	19	18	doublestranded	doublestranded	NNP
cord-002248-92pzqj35	19	19	RNA	RNA	NNP
cord-002248-92pzqj35	19	20	-	-	HYPH
cord-002248-92pzqj35	19	21	dependent	dependent	JJ
cord-002248-92pzqj35	19	22	protein	protein	NN
cord-002248-92pzqj35	19	23	kinase	kinase	NN
cord-002248-92pzqj35	19	24	R.	R.	NNP
cord-002248-92pzqj35	20	1	Although	although	IN
cord-002248-92pzqj35	20	2	each	each	DT
cord-002248-92pzqj35	20	3	of	of	IN
cord-002248-92pzqj35	20	4	these	these	DT
cord-002248-92pzqj35	20	5	biological	biological	JJ
cord-002248-92pzqj35	20	6	functions	function	NNS
cord-002248-92pzqj35	20	7	of	of	IN
cord-002248-92pzqj35	20	8	NSs	ns	NNS
cord-002248-92pzqj35	20	9	are	be	VBP
cord-002248-92pzqj35	20	10	considered	consider	VBN
cord-002248-92pzqj35	20	11	important	important	JJ
cord-002248-92pzqj35	20	12	for	for	IN
cord-002248-92pzqj35	20	13	countering	counter	VBG
cord-002248-92pzqj35	20	14	the	the	DT
cord-002248-92pzqj35	20	15	antiviral	antiviral	JJ
cord-002248-92pzqj35	20	16	response	response	NN
cord-002248-92pzqj35	20	17	in	in	IN
cord-002248-92pzqj35	20	18	the	the	DT
cord-002248-92pzqj35	20	19	host	host	NN
cord-002248-92pzqj35	20	20	,	,	,
cord-002248-92pzqj35	20	21	the	the	DT
cord-002248-92pzqj35	20	22	individual	individual	JJ
cord-002248-92pzqj35	20	23	contributions	contribution	NNS
cord-002248-92pzqj35	20	24	of	of	IN
cord-002248-92pzqj35	20	25	these	these	DT
cord-002248-92pzqj35	20	26	functions	function	NNS
cord-002248-92pzqj35	20	27	towards	towards	IN
cord-002248-92pzqj35	20	28	RVFV	RVFV	NNP
cord-002248-92pzqj35	20	29	virulence	virulence	NN
cord-002248-92pzqj35	20	30	remains	remain	VBZ
cord-002248-92pzqj35	20	31	unclear	unclear	JJ
cord-002248-92pzqj35	20	32	.	.	.
cord-002248-92pzqj35	21	1	To	to	TO
cord-002248-92pzqj35	21	2	examine	examine	VB
cord-002248-92pzqj35	21	3	this	this	DT
cord-002248-92pzqj35	21	4	,	,	,
cord-002248-92pzqj35	21	5	we	-PRON-	PRP
cord-002248-92pzqj35	21	6	generated	generate	VBD
cord-002248-92pzqj35	21	7	two	two	CD
cord-002248-92pzqj35	21	8	RVFV	RVFV	NNP
cord-002248-92pzqj35	21	9	MP-12	MP-12	NNP
cord-002248-92pzqj35	21	10	strain	strain	NN
cord-002248-92pzqj35	21	11	-	-	HYPH
cord-002248-92pzqj35	21	12	derived	derive	VBN
cord-002248-92pzqj35	21	13	mutant	mutant	JJ
cord-002248-92pzqj35	21	14	viruses	virus	NNS
cord-002248-92pzqj35	21	15	.	.	.
cord-002248-92pzqj35	22	1	Each	each	DT
cord-002248-92pzqj35	22	2	carried	carry	VBN
cord-002248-92pzqj35	22	3	mutations	mutation	NNS
cord-002248-92pzqj35	22	4	in	in	IN
cord-002248-92pzqj35	22	5	NSs	ns	NNS
cord-002248-92pzqj35	22	6	that	that	WDT
cord-002248-92pzqj35	22	7	specifically	specifically	RB
cord-002248-92pzqj35	22	8	targeted	target	VBD
cord-002248-92pzqj35	22	9	its	-PRON-	PRP$
cord-002248-92pzqj35	22	10	general	general	JJ
cord-002248-92pzqj35	22	11	transcription	transcription	NN
cord-002248-92pzqj35	22	12	inhibition	inhibition	NN
cord-002248-92pzqj35	22	13	function	function	NN
cord-002248-92pzqj35	22	14	without	without	IN
cord-002248-92pzqj35	22	15	affecting	affect	VBG
cord-002248-92pzqj35	22	16	its	-PRON-	PRP$
cord-002248-92pzqj35	22	17	ability	ability	NN
cord-002248-92pzqj35	22	18	to	to	TO
cord-002248-92pzqj35	22	19	degrade	degrade	VB
cord-002248-92pzqj35	22	20	PKR	PKR	NNP
cord-002248-92pzqj35	22	21	and	and	CC
cord-002248-92pzqj35	22	22	inhibit	inhibit	VB
cord-002248-92pzqj35	22	23	IFN	IFN	NNP
cord-002248-92pzqj35	22	24	-	-	HYPH
cord-002248-92pzqj35	22	25	β	β	NNP
cord-002248-92pzqj35	22	26	promoter	promoter	NN
cord-002248-92pzqj35	22	27	induction	induction	NN
cord-002248-92pzqj35	22	28	,	,	,
cord-002248-92pzqj35	22	29	through	through	IN
cord-002248-92pzqj35	22	30	its	-PRON-	PRP$
cord-002248-92pzqj35	22	31	interaction	interaction	NN
cord-002248-92pzqj35	22	32	with	with	IN
cord-002248-92pzqj35	22	33	Sin3-associated	sin3-associate	VBN
cord-002248-92pzqj35	22	34	protein	protein	NNP
cord-002248-92pzqj35	22	35	30	30	CD
cord-002248-92pzqj35	22	36	,	,	,
cord-002248-92pzqj35	22	37	a	a	DT
cord-002248-92pzqj35	22	38	part	part	NN
cord-002248-92pzqj35	22	39	of	of	IN
cord-002248-92pzqj35	22	40	the	the	DT
cord-002248-92pzqj35	22	41	repressor	repressor	NN
cord-002248-92pzqj35	22	42	complex	complex	NN
cord-002248-92pzqj35	22	43	at	at	IN
cord-002248-92pzqj35	22	44	the	the	DT
cord-002248-92pzqj35	22	45	IFN	IFN	NNP
cord-002248-92pzqj35	22	46	-	-	HYPH
cord-002248-92pzqj35	22	47	β	β	NNP
cord-002248-92pzqj35	22	48	promoter	promoter	NN
cord-002248-92pzqj35	22	49	.	.	.
cord-002248-92pzqj35	23	1	Using	use	VBG
cord-002248-92pzqj35	23	2	these	these	DT
cord-002248-92pzqj35	23	3	mutant	mutant	JJ
cord-002248-92pzqj35	23	4	viruses	virus	NNS
cord-002248-92pzqj35	23	5	,	,	,
cord-002248-92pzqj35	23	6	we	-PRON-	PRP
cord-002248-92pzqj35	23	7	have	have	VBP
cord-002248-92pzqj35	23	8	dissected	dissect	VBN
cord-002248-92pzqj35	23	9	the	the	DT
cord-002248-92pzqj35	23	10	transcription	transcription	NN
cord-002248-92pzqj35	23	11	inhibition	inhibition	NN
cord-002248-92pzqj35	23	12	function	function	NN
cord-002248-92pzqj35	23	13	of	of	IN
cord-002248-92pzqj35	23	14	NSs	ns	NNS
cord-002248-92pzqj35	23	15	and	and	CC
cord-002248-92pzqj35	23	16	examined	examine	VBD
cord-002248-92pzqj35	23	17	its	-PRON-	PRP$
cord-002248-92pzqj35	23	18	importance	importance	NN
cord-002248-92pzqj35	23	19	in	in	IN
cord-002248-92pzqj35	23	20	RVFV	RVFV	NNP
cord-002248-92pzqj35	23	21	virulence	virulence	NN
cord-002248-92pzqj35	23	22	.	.	.
cord-002248-92pzqj35	24	1	Both	both	DT
cord-002248-92pzqj35	24	2	NSs	NSs	NNP
cord-002248-92pzqj35	24	3	mutant	mutant	NN
cord-002248-92pzqj35	24	4	viruses	virus	NNS
cord-002248-92pzqj35	24	5	exhibited	exhibit	VBD
cord-002248-92pzqj35	24	6	a	a	DT
cord-002248-92pzqj35	24	7	differentially	differentially	RB
cord-002248-92pzqj35	24	8	impaired	impair	VBN
cord-002248-92pzqj35	24	9	ability	ability	NN
cord-002248-92pzqj35	24	10	to	to	TO
cord-002248-92pzqj35	24	11	inhibit	inhibit	VB
cord-002248-92pzqj35	24	12	host	host	NN
cord-002248-92pzqj35	24	13	transcription	transcription	NN
cord-002248-92pzqj35	24	14	when	when	WRB
cord-002248-92pzqj35	24	15	compared	compare	VBN
cord-002248-92pzqj35	24	16	with	with	IN
cord-002248-92pzqj35	24	17	MP-12	MP-12	NNP
cord-002248-92pzqj35	24	18	.	.	.
cord-002248-92pzqj35	25	1	It	-PRON-	PRP
cord-002248-92pzqj35	25	2	has	have	VBZ
cord-002248-92pzqj35	25	3	been	be	VBN
cord-002248-92pzqj35	25	4	reported	report	VBN
cord-002248-92pzqj35	25	5	that	that	IN
cord-002248-92pzqj35	25	6	NSs	NSs	NNP
cord-002248-92pzqj35	25	7	suppresses	suppress	VBZ
cord-002248-92pzqj35	25	8	general	general	JJ
cord-002248-92pzqj35	25	9	transcription	transcription	NN
cord-002248-92pzqj35	25	10	by	by	IN
cord-002248-92pzqj35	25	11	interfering	interfere	VBG
cord-002248-92pzqj35	25	12	with	with	IN
cord-002248-92pzqj35	25	13	the	the	DT
cord-002248-92pzqj35	25	14	formation	formation	NN
cord-002248-92pzqj35	25	15	of	of	IN
cord-002248-92pzqj35	25	16	the	the	DT
cord-002248-92pzqj35	25	17	transcription	transcription	NN
cord-002248-92pzqj35	25	18	factor	factor	NN
cord-002248-92pzqj35	25	19	IIH	IIH	NNP
cord-002248-92pzqj35	25	20	complex	complex	NN
cord-002248-92pzqj35	25	21	,	,	,
cord-002248-92pzqj35	25	22	through	through	IN
cord-002248-92pzqj35	25	23	the	the	DT
cord-002248-92pzqj35	25	24	degradation	degradation	NN
cord-002248-92pzqj35	25	25	of	of	IN
cord-002248-92pzqj35	25	26	the	the	DT
cord-002248-92pzqj35	25	27	p62	p62	NN
cord-002248-92pzqj35	25	28	subunit	subunit	NN
cord-002248-92pzqj35	25	29	and	and	CC
cord-002248-92pzqj35	25	30	sequestration	sequestration	NN
cord-002248-92pzqj35	25	31	of	of	IN
cord-002248-92pzqj35	25	32	the	the	DT
cord-002248-92pzqj35	25	33	p44	p44	NN
cord-002248-92pzqj35	25	34	subunit	subunit	NN
cord-002248-92pzqj35	25	35	.	.	.
cord-002248-92pzqj35	26	1	Our	-PRON-	PRP$
cord-002248-92pzqj35	26	2	study	study	NN
cord-002248-92pzqj35	26	3	results	result	NNS
cord-002248-92pzqj35	26	4	lead	lead	VBP
cord-002248-92pzqj35	26	5	us	-PRON-	PRP
cord-002248-92pzqj35	26	6	to	to	TO
cord-002248-92pzqj35	26	7	suggest	suggest	VB
cord-002248-92pzqj35	26	8	that	that	IN
cord-002248-92pzqj35	26	9	the	the	DT
cord-002248-92pzqj35	26	10	ability	ability	NN
cord-002248-92pzqj35	26	11	of	of	IN
cord-002248-92pzqj35	26	12	NSs	ns	NNS
cord-002248-92pzqj35	26	13	to	to	TO
cord-002248-92pzqj35	26	14	induce	induce	VB
cord-002248-92pzqj35	26	15	p62	p62	NN
cord-002248-92pzqj35	26	16	degradation	degradation	NN
cord-002248-92pzqj35	26	17	is	be	VBZ
cord-002248-92pzqj35	26	18	the	the	DT
cord-002248-92pzqj35	26	19	major	major	JJ
cord-002248-92pzqj35	26	20	contributor	contributor	NN
cord-002248-92pzqj35	26	21	to	to	IN
cord-002248-92pzqj35	26	22	its	-PRON-	PRP$
cord-002248-92pzqj35	26	23	general	general	JJ
cord-002248-92pzqj35	26	24	transcription	transcription	NN
cord-002248-92pzqj35	26	25	inhibition	inhibition	NN
cord-002248-92pzqj35	26	26	property	property	NN
cord-002248-92pzqj35	26	27	,	,	,
cord-002248-92pzqj35	26	28	whereas	whereas	IN
cord-002248-92pzqj35	26	29	its	-PRON-	PRP$
cord-002248-92pzqj35	26	30	interaction	interaction	NN
cord-002248-92pzqj35	26	31	with	with	IN
cord-002248-92pzqj35	26	32	p44	p44	CD
cord-002248-92pzqj35	26	33	may	may	MD
cord-002248-92pzqj35	26	34	not	not	RB
cord-002248-92pzqj35	26	35	play	play	VB
cord-002248-92pzqj35	26	36	a	a	DT
cord-002248-92pzqj35	26	37	significant	significant	JJ
cord-002248-92pzqj35	26	38	role	role	NN
cord-002248-92pzqj35	26	39	in	in	IN
cord-002248-92pzqj35	26	40	this	this	DT
cord-002248-92pzqj35	26	41	function	function	NN
cord-002248-92pzqj35	26	42	.	.	.
cord-002248-92pzqj35	27	1	Importantly	importantly	RB
cord-002248-92pzqj35	27	2	,	,	,
cord-002248-92pzqj35	27	3	RVFV	RVFV	NNP
cord-002248-92pzqj35	27	4	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	27	5	mutant	mutant	JJ
cord-002248-92pzqj35	27	6	viruses	virus	NNS
cord-002248-92pzqj35	27	7	with	with	IN
cord-002248-92pzqj35	27	8	an	an	DT
cord-002248-92pzqj35	27	9	impaired	impaired	JJ
cord-002248-92pzqj35	27	10	general	general	JJ
cord-002248-92pzqj35	27	11	transcription	transcription	NN
cord-002248-92pzqj35	27	12	inhibition	inhibition	NN
cord-002248-92pzqj35	27	13	function	function	NN
cord-002248-92pzqj35	27	14	showed	show	VBD
cord-002248-92pzqj35	27	15	a	a	DT
cord-002248-92pzqj35	27	16	reduced	reduce	VBN
cord-002248-92pzqj35	27	17	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	27	18	in	in	IN
cord-002248-92pzqj35	27	19	cell	cell	NN
cord-002248-92pzqj35	27	20	culture	culture	NN
cord-002248-92pzqj35	27	21	and	and	CC
cord-002248-92pzqj35	27	22	attenuated	attenuated	JJ
cord-002248-92pzqj35	27	23	virulence	virulence	NN
cord-002248-92pzqj35	27	24	in	in	IN
cord-002248-92pzqj35	27	25	young	young	JJ
cord-002248-92pzqj35	27	26	mice	mouse	NNS
cord-002248-92pzqj35	27	27	,	,	,
cord-002248-92pzqj35	27	28	Rift	Rift	NNP
cord-002248-92pzqj35	27	29	Valley	Valley	NNP
cord-002248-92pzqj35	27	30	fever	fever	NN
cord-002248-92pzqj35	27	31	virus	virus	NN
cord-002248-92pzqj35	27	32	(	(	-LRB-
cord-002248-92pzqj35	27	33	RVFV	RVFV	NNP
cord-002248-92pzqj35	27	34	)	)	-RRB-
cord-002248-92pzqj35	27	35	is	be	VBZ
cord-002248-92pzqj35	27	36	the	the	DT
cord-002248-92pzqj35	27	37	pathogen	pathogen	NN
cord-002248-92pzqj35	27	38	causing	cause	VBG
cord-002248-92pzqj35	27	39	Rift	Rift	NNP
cord-002248-92pzqj35	27	40	Valley	Valley	NNP
cord-002248-92pzqj35	27	41	fever	fever	NN
cord-002248-92pzqj35	27	42	,	,	,
cord-002248-92pzqj35	27	43	which	which	WDT
cord-002248-92pzqj35	27	44	affects	affect	VBZ
cord-002248-92pzqj35	27	45	both	both	DT
cord-002248-92pzqj35	27	46	humans	human	NNS
cord-002248-92pzqj35	27	47	and	and	CC
cord-002248-92pzqj35	27	48	domestic	domestic	JJ
cord-002248-92pzqj35	27	49	ruminants	ruminant	NNS
cord-002248-92pzqj35	27	50	,	,	,
cord-002248-92pzqj35	27	51	primarily	primarily	RB
cord-002248-92pzqj35	27	52	in	in	IN
cord-002248-92pzqj35	27	53	countries	country	NNS
cord-002248-92pzqj35	27	54	of	of	IN
cord-002248-92pzqj35	27	55	the	the	DT
cord-002248-92pzqj35	27	56	African	african	JJ
cord-002248-92pzqj35	27	57	continent	continent	NN
cord-002248-92pzqj35	27	58	and	and	CC
cord-002248-92pzqj35	27	59	Middle	Middle	NNP
cord-002248-92pzqj35	27	60	East	East	NNP
cord-002248-92pzqj35	27	61	.	.	.
cord-002248-92pzqj35	28	1	The	the	DT
cord-002248-92pzqj35	28	2	virus	virus	NN
cord-002248-92pzqj35	28	3	is	be	VBZ
cord-002248-92pzqj35	28	4	an	an	DT
cord-002248-92pzqj35	28	5	arbovirus	arbovirus	NN
cord-002248-92pzqj35	28	6	and	and	CC
cord-002248-92pzqj35	28	7	circulates	circulate	VBZ
cord-002248-92pzqj35	28	8	between	between	IN
cord-002248-92pzqj35	28	9	mosquito	mosquito	NN
cord-002248-92pzqj35	28	10	vectors	vector	NNS
cord-002248-92pzqj35	28	11	and	and	CC
cord-002248-92pzqj35	28	12	ruminants	ruminant	NNS
cord-002248-92pzqj35	28	13	in	in	IN
cord-002248-92pzqj35	28	14	endemic	endemic	JJ
cord-002248-92pzqj35	28	15	areas	area	NNS
cord-002248-92pzqj35	28	16	.	.	.
cord-002248-92pzqj35	29	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	29	2	causes	cause	VBZ
cord-002248-92pzqj35	29	3	high	high	JJ
cord-002248-92pzqj35	29	4	mortality	mortality	NN
cord-002248-92pzqj35	29	5	rates	rate	NNS
cord-002248-92pzqj35	29	6	in	in	IN
cord-002248-92pzqj35	29	7	young	young	JJ
cord-002248-92pzqj35	29	8	ruminants	ruminant	NNS
cord-002248-92pzqj35	29	9	and	and	CC
cord-002248-92pzqj35	29	10	a	a	DT
cord-002248-92pzqj35	29	11	high	high	JJ
cord-002248-92pzqj35	29	12	rate	rate	NN
cord-002248-92pzqj35	29	13	of	of	IN
cord-002248-92pzqj35	29	14	abortions	abortion	NNS
cord-002248-92pzqj35	29	15	in	in	IN
cord-002248-92pzqj35	29	16	pregnant	pregnant	JJ
cord-002248-92pzqj35	29	17	ruminants	ruminant	NNS
cord-002248-92pzqj35	29	18	[	[	-LRB-
cord-002248-92pzqj35	29	19	1	1	CD
cord-002248-92pzqj35	29	20	]	]	-RRB-
cord-002248-92pzqj35	29	21	.	.	.
cord-002248-92pzqj35	30	1	Humans	human	NNS
cord-002248-92pzqj35	30	2	are	be	VBP
cord-002248-92pzqj35	30	3	infected	infect	VBN
cord-002248-92pzqj35	30	4	with	with	IN
cord-002248-92pzqj35	30	5	the	the	DT
cord-002248-92pzqj35	30	6	virus	virus	NN
cord-002248-92pzqj35	30	7	either	either	CC
cord-002248-92pzqj35	30	8	by	by	IN
cord-002248-92pzqj35	30	9	mosquito	mosquito	NN
cord-002248-92pzqj35	30	10	bite	bite	NN
cord-002248-92pzqj35	30	11	or	or	CC
cord-002248-92pzqj35	30	12	by	by	IN
cord-002248-92pzqj35	30	13	direct	direct	JJ
cord-002248-92pzqj35	30	14	contact	contact	NN
cord-002248-92pzqj35	30	15	with	with	IN
cord-002248-92pzqj35	30	16	materials	material	NNS
cord-002248-92pzqj35	30	17	of	of	IN
cord-002248-92pzqj35	30	18	infected	infected	JJ
cord-002248-92pzqj35	30	19	animals	animal	NNS
cord-002248-92pzqj35	30	20	.	.	.
cord-002248-92pzqj35	31	1	The	the	DT
cord-002248-92pzqj35	31	2	majority	majority	NN
cord-002248-92pzqj35	31	3	of	of	IN
cord-002248-92pzqj35	31	4	patients	patient	NNS
cord-002248-92pzqj35	31	5	show	show	VBP
cord-002248-92pzqj35	31	6	influenzalike	influenzalike	JJ
cord-002248-92pzqj35	31	7	symptoms	symptom	NNS
cord-002248-92pzqj35	31	8	but	but	CC
cord-002248-92pzqj35	31	9	few	few	JJ
cord-002248-92pzqj35	31	10	develop	develop	VB
cord-002248-92pzqj35	31	11	hemorrhagic	hemorrhagic	JJ
cord-002248-92pzqj35	31	12	fever	fever	NN
cord-002248-92pzqj35	31	13	,	,	,
cord-002248-92pzqj35	31	14	neurological	neurological	JJ
cord-002248-92pzqj35	31	15	symptoms	symptom	NNS
cord-002248-92pzqj35	31	16	,	,	,
cord-002248-92pzqj35	31	17	and	and	CC
cord-002248-92pzqj35	31	18	ocular	ocular	JJ
cord-002248-92pzqj35	31	19	disease	disease	NN
cord-002248-92pzqj35	31	20	[	[	-LRB-
cord-002248-92pzqj35	31	21	2	2	CD
cord-002248-92pzqj35	31	22	]	]	-RRB-
cord-002248-92pzqj35	31	23	.	.	.
cord-002248-92pzqj35	32	1	Due	due	IN
cord-002248-92pzqj35	32	2	to	to	IN
cord-002248-92pzqj35	32	3	its	-PRON-	PRP$
cord-002248-92pzqj35	32	4	major	major	JJ
cord-002248-92pzqj35	32	5	impact	impact	NN
cord-002248-92pzqj35	32	6	on	on	IN
cord-002248-92pzqj35	32	7	public	public	JJ
cord-002248-92pzqj35	32	8	health	health	NN
cord-002248-92pzqj35	32	9	,	,	,
cord-002248-92pzqj35	32	10	RVFV	RVFV	NNP
cord-002248-92pzqj35	32	11	is	be	VBZ
cord-002248-92pzqj35	32	12	classified	classify	VBN
cord-002248-92pzqj35	32	13	as	as	IN
cord-002248-92pzqj35	32	14	a	a	DT
cord-002248-92pzqj35	32	15	category	category	NN
cord-002248-92pzqj35	32	16	A	a	DT
cord-002248-92pzqj35	32	17	priority	priority	NN
cord-002248-92pzqj35	32	18	pathogen	pathogen	NN
cord-002248-92pzqj35	32	19	by	by	IN
cord-002248-92pzqj35	32	20	the	the	DT
cord-002248-92pzqj35	32	21	National	National	NNP
cord-002248-92pzqj35	32	22	Institute	Institute	NNP
cord-002248-92pzqj35	32	23	of	of	IN
cord-002248-92pzqj35	32	24	Allergy	Allergy	NNP
cord-002248-92pzqj35	32	25	and	and	CC
cord-002248-92pzqj35	32	26	Infectious	Infectious	NNP
cord-002248-92pzqj35	32	27	Diseases	Diseases	NNPS
cord-002248-92pzqj35	32	28	.	.	.
cord-002248-92pzqj35	33	1	Currently	currently	RB
cord-002248-92pzqj35	33	2	there	there	EX
cord-002248-92pzqj35	33	3	is	be	VBZ
cord-002248-92pzqj35	33	4	no	no	DT
cord-002248-92pzqj35	33	5	approved	approve	VBN
cord-002248-92pzqj35	33	6	vaccine	vaccine	NN
cord-002248-92pzqj35	33	7	available	available	JJ
cord-002248-92pzqj35	33	8	for	for	IN
cord-002248-92pzqj35	33	9	humans	human	NNS
cord-002248-92pzqj35	33	10	and	and	CC
cord-002248-92pzqj35	33	11	animals	animal	NNS
cord-002248-92pzqj35	33	12	in	in	IN
cord-002248-92pzqj35	33	13	non	non	JJ
cord-002248-92pzqj35	33	14	-	-	JJ
cord-002248-92pzqj35	33	15	endemic	endemic	JJ
cord-002248-92pzqj35	33	16	areas	area	NNS
cord-002248-92pzqj35	33	17	.	.	.
cord-002248-92pzqj35	34	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	34	2	belongs	belong	VBZ
cord-002248-92pzqj35	34	3	to	to	IN
cord-002248-92pzqj35	34	4	the	the	DT
cord-002248-92pzqj35	34	5	family	family	NN
cord-002248-92pzqj35	34	6	Bunyaviridae	Bunyaviridae	NNP
cord-002248-92pzqj35	34	7	,	,	,
cord-002248-92pzqj35	34	8	genus	genus	NN
cord-002248-92pzqj35	34	9	Phlebovirus	Phlebovirus	NNP
cord-002248-92pzqj35	34	10	.	.	.
cord-002248-92pzqj35	35	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	35	2	is	be	VBZ
cord-002248-92pzqj35	35	3	an	an	DT
cord-002248-92pzqj35	35	4	enveloped	envelop	VBN
cord-002248-92pzqj35	35	5	virus	virus	NN
cord-002248-92pzqj35	35	6	and	and	CC
cord-002248-92pzqj35	35	7	carries	carry	VBZ
cord-002248-92pzqj35	35	8	3	3	CD
cord-002248-92pzqj35	35	9	segmented	segmented	JJ
cord-002248-92pzqj35	35	10	RNA	RNA	NNP
cord-002248-92pzqj35	35	11	genomes	genome	NNS
cord-002248-92pzqj35	35	12	,	,	,
cord-002248-92pzqj35	35	13	the	the	DT
cord-002248-92pzqj35	35	14	L	L	NNP
cord-002248-92pzqj35	35	15	,	,	,
cord-002248-92pzqj35	35	16	M	M	NNP
cord-002248-92pzqj35	35	17	and	and	CC
cord-002248-92pzqj35	35	18	S	S	NNP
cord-002248-92pzqj35	35	19	segments	segment	NNS
cord-002248-92pzqj35	35	20	,	,	,
cord-002248-92pzqj35	35	21	which	which	WDT
cord-002248-92pzqj35	35	22	are	be	VBP
cord-002248-92pzqj35	35	23	of	of	IN
cord-002248-92pzqj35	35	24	negative	negative	JJ
cord-002248-92pzqj35	35	25	or	or	CC
cord-002248-92pzqj35	35	26	ambisense	ambisense	NN
cord-002248-92pzqj35	35	27	polarity	polarity	NN
cord-002248-92pzqj35	35	28	.	.	.
cord-002248-92pzqj35	36	1	The	the	DT
cord-002248-92pzqj35	36	2	L	L	NNP
cord-002248-92pzqj35	36	3	segment	segment	NN
cord-002248-92pzqj35	36	4	encodes	encode	VBZ
cord-002248-92pzqj35	36	5	L	L	NNP
cord-002248-92pzqj35	36	6	protein	protein	NN
cord-002248-92pzqj35	36	7	,	,	,
cord-002248-92pzqj35	36	8	a	a	DT
cord-002248-92pzqj35	36	9	viral	viral	JJ
cord-002248-92pzqj35	36	10	RNA	rna	NN
cord-002248-92pzqj35	36	11	-	-	HYPH
cord-002248-92pzqj35	36	12	dependent	dependent	JJ
cord-002248-92pzqj35	36	13	RNA	RNA	NNP
cord-002248-92pzqj35	36	14	polymerase	polymerase	NN
cord-002248-92pzqj35	36	15	.	.	.
cord-002248-92pzqj35	37	1	M	M	NNP
cord-002248-92pzqj35	37	2	RNA	RNA	NNP
cord-002248-92pzqj35	37	3	encodes	encode	VBZ
cord-002248-92pzqj35	37	4	78kDa	78kDa	NNP
cord-002248-92pzqj35	37	5	protein	protein	NN
cord-002248-92pzqj35	37	6	,	,	,
cord-002248-92pzqj35	37	7	NSm	NSm	NNS
cord-002248-92pzqj35	37	8	protein	protein	NN
cord-002248-92pzqj35	37	9	,	,	,
cord-002248-92pzqj35	37	10	Gn	Gn	NNP
cord-002248-92pzqj35	37	11	protein	protein	NN
cord-002248-92pzqj35	37	12	and	and	CC
cord-002248-92pzqj35	37	13	Gc	Gc	NNP
cord-002248-92pzqj35	37	14	protein	protein	NN
cord-002248-92pzqj35	37	15	,	,	,
cord-002248-92pzqj35	37	16	the	the	DT
cord-002248-92pzqj35	37	17	latter	latter	JJ
cord-002248-92pzqj35	37	18	two	two	CD
cord-002248-92pzqj35	37	19	of	of	IN
cord-002248-92pzqj35	37	20	which	which	WDT
cord-002248-92pzqj35	37	21	are	be	VBP
cord-002248-92pzqj35	37	22	major	major	JJ
cord-002248-92pzqj35	37	23	envelope	envelope	NN
cord-002248-92pzqj35	37	24	glycoproteins	glycoprotein	NNS
cord-002248-92pzqj35	37	25	and	and	CC
cord-002248-92pzqj35	37	26	generated	generate	VBN
cord-002248-92pzqj35	37	27	by	by	IN
cord-002248-92pzqj35	37	28	co	co	JJ
cord-002248-92pzqj35	37	29	-	-	JJ
cord-002248-92pzqj35	37	30	translational	translational	JJ
cord-002248-92pzqj35	37	31	cleavage	cleavage	NN
cord-002248-92pzqj35	37	32	of	of	IN
cord-002248-92pzqj35	37	33	precursor	precursor	NN
cord-002248-92pzqj35	37	34	Gn	Gn	NNP
cord-002248-92pzqj35	37	35	/	/	SYM
cord-002248-92pzqj35	37	36	Gc	Gc	NNP
cord-002248-92pzqj35	37	37	polyprotein	polyprotein	NNP
cord-002248-92pzqj35	37	38	.	.	.
cord-002248-92pzqj35	38	1	78kDa	78kDa	NNP
cord-002248-92pzqj35	38	2	protein	protein	NN
cord-002248-92pzqj35	38	3	is	be	VBZ
cord-002248-92pzqj35	38	4	dispensable	dispensable	JJ
cord-002248-92pzqj35	38	5	for	for	IN
cord-002248-92pzqj35	38	6	virus	virus	NN
cord-002248-92pzqj35	38	7	replication	replication	NN
cord-002248-92pzqj35	38	8	[	[	-LRB-
cord-002248-92pzqj35	38	9	3	3	CD
cord-002248-92pzqj35	38	10	]	]	-RRB-
cord-002248-92pzqj35	38	11	,	,	,
cord-002248-92pzqj35	38	12	whereas	whereas	IN
cord-002248-92pzqj35	38	13	it	-PRON-	PRP
cord-002248-92pzqj35	38	14	plays	play	VBZ
cord-002248-92pzqj35	38	15	important	important	JJ
cord-002248-92pzqj35	38	16	roles	role	NNS
cord-002248-92pzqj35	38	17	in	in	IN
cord-002248-92pzqj35	38	18	virus	virus	NN
cord-002248-92pzqj35	38	19	dissemination	dissemination	NN
cord-002248-92pzqj35	38	20	in	in	IN
cord-002248-92pzqj35	38	21	mosquitoes	mosquito	NNS
cord-002248-92pzqj35	38	22	[	[	-LRB-
cord-002248-92pzqj35	38	23	4	4	CD
cord-002248-92pzqj35	38	24	,	,	,
cord-002248-92pzqj35	38	25	5	5	CD
cord-002248-92pzqj35	38	26	]	]	-RRB-
cord-002248-92pzqj35	38	27	.	.	.
cord-002248-92pzqj35	39	1	NSm	NSm	NNP
cord-002248-92pzqj35	39	2	is	be	VBZ
cord-002248-92pzqj35	39	3	a	a	DT
cord-002248-92pzqj35	39	4	viral	viral	JJ
cord-002248-92pzqj35	39	5	anti	anti	JJ
cord-002248-92pzqj35	39	6	-	-	JJ
cord-002248-92pzqj35	39	7	apoptotic	apoptotic	JJ
cord-002248-92pzqj35	39	8	protein	protein	NN
cord-002248-92pzqj35	39	9	[	[	-LRB-
cord-002248-92pzqj35	39	10	6	6	CD
cord-002248-92pzqj35	39	11	,	,	,
cord-002248-92pzqj35	39	12	7	7	CD
cord-002248-92pzqj35	39	13	]	]	-RRB-
cord-002248-92pzqj35	39	14	and	and	CC
cord-002248-92pzqj35	39	15	also	also	RB
cord-002248-92pzqj35	39	16	is	be	VBZ
cord-002248-92pzqj35	39	17	important	important	JJ
cord-002248-92pzqj35	39	18	for	for	IN
cord-002248-92pzqj35	39	19	efficient	efficient	JJ
cord-002248-92pzqj35	39	20	virus	virus	NN
cord-002248-92pzqj35	39	21	replication	replication	NN
cord-002248-92pzqj35	39	22	in	in	IN
cord-002248-92pzqj35	39	23	macrophage	macrophage	NN
cord-002248-92pzqj35	39	24	cell	cell	NN
cord-002248-92pzqj35	39	25	lines	line	NNS
cord-002248-92pzqj35	39	26	[	[	-LRB-
cord-002248-92pzqj35	39	27	5	5	CD
cord-002248-92pzqj35	39	28	]	]	-RRB-
cord-002248-92pzqj35	39	29	.	.	.
cord-002248-92pzqj35	40	1	S	S	NNP
cord-002248-92pzqj35	40	2	RNA	RNA	NNP
cord-002248-92pzqj35	40	3	expresses	express	VBZ
cord-002248-92pzqj35	40	4	a	a	DT
cord-002248-92pzqj35	40	5	nucleocapsid	nucleocapsid	NN
cord-002248-92pzqj35	40	6	(	(	-LRB-
cord-002248-92pzqj35	40	7	N	N	NNP
cord-002248-92pzqj35	40	8	)	)	-RRB-
cord-002248-92pzqj35	40	9	protein	protein	NN
cord-002248-92pzqj35	40	10	and	and	CC
cord-002248-92pzqj35	40	11	a	a	DT
cord-002248-92pzqj35	40	12	nonstructural	nonstructural	JJ
cord-002248-92pzqj35	40	13	protein	protein	NN
cord-002248-92pzqj35	40	14	NSs	ns	NNS
cord-002248-92pzqj35	40	15	by	by	IN
cord-002248-92pzqj35	40	16	using	use	VBG
cord-002248-92pzqj35	40	17	an	an	DT
cord-002248-92pzqj35	40	18	ambisense	ambisense	NN
cord-002248-92pzqj35	40	19	coding	coding	NN
cord-002248-92pzqj35	40	20	strategy	strategy	NN
cord-002248-92pzqj35	40	21	.	.	.
cord-002248-92pzqj35	41	1	The	the	DT
cord-002248-92pzqj35	41	2	N	N	NNP
cord-002248-92pzqj35	41	3	protein	protein	NN
cord-002248-92pzqj35	41	4	encapsidates	encapsidate	VBZ
cord-002248-92pzqj35	41	5	the	the	DT
cord-002248-92pzqj35	41	6	viral	viral	JJ
cord-002248-92pzqj35	41	7	RNA	RNA	NNP
cord-002248-92pzqj35	41	8	and	and	CC
cord-002248-92pzqj35	41	9	forms	form	VBZ
cord-002248-92pzqj35	41	10	a	a	DT
cord-002248-92pzqj35	41	11	ribonucleocapsid	ribonucleocapsid	NNP
cord-002248-92pzqj35	41	12	complex	complex	NN
cord-002248-92pzqj35	41	13	with	with	IN
cord-002248-92pzqj35	41	14	L	l	NN
cord-002248-92pzqj35	41	15	protein	protein	NN
cord-002248-92pzqj35	41	16	[	[	-LRB-
cord-002248-92pzqj35	41	17	8	8	CD
cord-002248-92pzqj35	41	18	]	]	-RRB-
cord-002248-92pzqj35	41	19	.	.	.
cord-002248-92pzqj35	42	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	42	2	NSs	NSs	NNP
cord-002248-92pzqj35	42	3	protein	protein	NN
cord-002248-92pzqj35	42	4	is	be	VBZ
cord-002248-92pzqj35	42	5	a	a	DT
cord-002248-92pzqj35	42	6	phosphoprotein	phosphoprotein	NN
cord-002248-92pzqj35	42	7	with	with	IN
cord-002248-92pzqj35	42	8	an	an	DT
cord-002248-92pzqj35	42	9	apparent	apparent	JJ
cord-002248-92pzqj35	42	10	molecular	molecular	JJ
cord-002248-92pzqj35	42	11	weight	weight	NN
cord-002248-92pzqj35	42	12	of	of	IN
cord-002248-92pzqj35	42	13	31	31	CD
cord-002248-92pzqj35	42	14	kDa	kDa	NNS
cord-002248-92pzqj35	42	15	and	and	CC
cord-002248-92pzqj35	42	16	is	be	VBZ
cord-002248-92pzqj35	42	17	localized	localize	VBN
cord-002248-92pzqj35	42	18	in	in	IN
cord-002248-92pzqj35	42	19	both	both	CC
cord-002248-92pzqj35	42	20	the	the	DT
cord-002248-92pzqj35	42	21	cytoplasm	cytoplasm	NN
cord-002248-92pzqj35	42	22	and	and	CC
cord-002248-92pzqj35	42	23	nucleus	nucleus	NN
cord-002248-92pzqj35	42	24	[	[	-LRB-
cord-002248-92pzqj35	42	25	9	9	CD
cord-002248-92pzqj35	42	26	]	]	-RRB-
cord-002248-92pzqj35	42	27	.	.	.
cord-002248-92pzqj35	43	1	In	in	IN
cord-002248-92pzqj35	43	2	the	the	DT
cord-002248-92pzqj35	43	3	nucleus	nucleus	NN
cord-002248-92pzqj35	43	4	,	,	,
cord-002248-92pzqj35	43	5	NSs	NSs	NNP
cord-002248-92pzqj35	43	6	forms	form	NNS
cord-002248-92pzqj35	43	7	filament	filament	NN
cord-002248-92pzqj35	43	8	-	-	HYPH
cord-002248-92pzqj35	43	9	like	like	JJ
cord-002248-92pzqj35	43	10	structures	structure	NNS
cord-002248-92pzqj35	43	11	by	by	IN
cord-002248-92pzqj35	43	12	self	self	NN
cord-002248-92pzqj35	43	13	-	-	HYPH
cord-002248-92pzqj35	43	14	dimerization	dimerization	NN
cord-002248-92pzqj35	43	15	through	through	IN
cord-002248-92pzqj35	43	16	its	-PRON-	PRP$
cord-002248-92pzqj35	43	17	C	c	NN
cord-002248-92pzqj35	43	18	-	-	HYPH
cord-002248-92pzqj35	43	19	terminal	terminal	NN
cord-002248-92pzqj35	43	20	domain	domain	NN
cord-002248-92pzqj35	43	21	[	[	-LRB-
cord-002248-92pzqj35	43	22	10	10	CD
cord-002248-92pzqj35	43	23	]	]	-RRB-
cord-002248-92pzqj35	43	24	.	.	.
cord-002248-92pzqj35	44	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	44	2	NSs	NSs	NNP
cord-002248-92pzqj35	44	3	protein	protein	NN
cord-002248-92pzqj35	44	4	is	be	VBZ
cord-002248-92pzqj35	44	5	a	a	DT
cord-002248-92pzqj35	44	6	major	major	JJ
cord-002248-92pzqj35	44	7	virus	virus	NN
cord-002248-92pzqj35	44	8	virulence	virulence	NN
cord-002248-92pzqj35	44	9	factor	factor	NN
cord-002248-92pzqj35	44	10	and	and	CC
cord-002248-92pzqj35	44	11	has	have	VBZ
cord-002248-92pzqj35	44	12	various	various	JJ
cord-002248-92pzqj35	44	13	important	important	JJ
cord-002248-92pzqj35	44	14	biological	biological	JJ
cord-002248-92pzqj35	44	15	functions	function	NNS
cord-002248-92pzqj35	44	16	,	,	,
cord-002248-92pzqj35	44	17	which	which	WDT
cord-002248-92pzqj35	44	18	are	be	VBP
cord-002248-92pzqj35	44	19	important	important	JJ
cord-002248-92pzqj35	44	20	for	for	IN
cord-002248-92pzqj35	44	21	countering	counter	VBG
cord-002248-92pzqj35	44	22	the	the	DT
cord-002248-92pzqj35	44	23	host	host	NN
cord-002248-92pzqj35	44	24	antiviral	antiviral	JJ
cord-002248-92pzqj35	44	25	response	response	NN
cord-002248-92pzqj35	44	26	.	.	.
cord-002248-92pzqj35	45	1	One	one	CD
cord-002248-92pzqj35	45	2	of	of	IN
cord-002248-92pzqj35	45	3	the	the	DT
cord-002248-92pzqj35	45	4	NSs	NSs	NNP
cord-002248-92pzqj35	45	5	functions	function	NNS
cord-002248-92pzqj35	45	6	is	be	VBZ
cord-002248-92pzqj35	45	7	suppression	suppression	NN
cord-002248-92pzqj35	45	8	of	of	IN
cord-002248-92pzqj35	45	9	IFN	IFN	NNP
cord-002248-92pzqj35	45	10	-	-	HYPH
cord-002248-92pzqj35	45	11	β	β	NNP
cord-002248-92pzqj35	45	12	mRNA	mrna	NN
cord-002248-92pzqj35	45	13	transcription	transcription	NN
cord-002248-92pzqj35	45	14	.	.	.
cord-002248-92pzqj35	46	1	NSs	NSs	NNP
cord-002248-92pzqj35	46	2	binds	bind	VBZ
cord-002248-92pzqj35	46	3	to	to	IN
cord-002248-92pzqj35	46	4	Sin3-associated	sin3-associate	VBN
cord-002248-92pzqj35	46	5	protein	protein	NN
cord-002248-92pzqj35	46	6	30	30	CD
cord-002248-92pzqj35	46	7	(	(	-LRB-
cord-002248-92pzqj35	46	8	SAP30	SAP30	NNP
cord-002248-92pzqj35	46	9	)	)	-RRB-
cord-002248-92pzqj35	46	10	,	,	,
cord-002248-92pzqj35	46	11	a	a	DT
cord-002248-92pzqj35	46	12	subunit	subunit	NN
cord-002248-92pzqj35	46	13	of	of	IN
cord-002248-92pzqj35	46	14	a	a	DT
cord-002248-92pzqj35	46	15	corepressor	corepressor	NN
cord-002248-92pzqj35	46	16	complex	complex	NN
cord-002248-92pzqj35	46	17	,	,	,
cord-002248-92pzqj35	46	18	and	and	CC
cord-002248-92pzqj35	46	19	maintains	maintain	VBZ
cord-002248-92pzqj35	46	20	IFN	IFN	NNP
cord-002248-92pzqj35	46	21	-	-	HYPH
cord-002248-92pzqj35	46	22	β	β	NNP
cord-002248-92pzqj35	46	23	promoter	promoter	NN
cord-002248-92pzqj35	46	24	in	in	IN
cord-002248-92pzqj35	46	25	a	a	DT
cord-002248-92pzqj35	46	26	transcriptionally	transcriptionally	RB
cord-002248-92pzqj35	46	27	silent	silent	JJ
cord-002248-92pzqj35	46	28	state	state	NN
cord-002248-92pzqj35	46	29	,	,	,
cord-002248-92pzqj35	46	30	leading	lead	VBG
cord-002248-92pzqj35	46	31	to	to	IN
cord-002248-92pzqj35	46	32	suppression	suppression	NN
cord-002248-92pzqj35	46	33	of	of	IN
cord-002248-92pzqj35	46	34	IFN	IFN	NNP
cord-002248-92pzqj35	46	35	-	-	HYPH
cord-002248-92pzqj35	46	36	β	β	NNP
cord-002248-92pzqj35	46	37	mRNA	mrna	NN
cord-002248-92pzqj35	46	38	transcription	transcription	NN
cord-002248-92pzqj35	46	39	[	[	-LRB-
cord-002248-92pzqj35	46	40	11	11	CD
cord-002248-92pzqj35	46	41	]	]	-RRB-
cord-002248-92pzqj35	46	42	.	.	.
cord-002248-92pzqj35	47	1	In	in	IN
cord-002248-92pzqj35	47	2	addition	addition	NN
cord-002248-92pzqj35	47	3	to	to	IN
cord-002248-92pzqj35	47	4	the	the	DT
cord-002248-92pzqj35	47	5	specific	specific	JJ
cord-002248-92pzqj35	47	6	inhibition	inhibition	NN
cord-002248-92pzqj35	47	7	of	of	IN
cord-002248-92pzqj35	47	8	IFN	IFN	NNP
cord-002248-92pzqj35	47	9	-	-	HYPH
cord-002248-92pzqj35	47	10	β	β	NNP
cord-002248-92pzqj35	47	11	transcription	transcription	NN
cord-002248-92pzqj35	47	12	,	,	,
cord-002248-92pzqj35	47	13	NSs	NSs	NNP
cord-002248-92pzqj35	47	14	suppresses	suppress	VBZ
cord-002248-92pzqj35	47	15	general	general	JJ
cord-002248-92pzqj35	47	16	transcription	transcription	NN
cord-002248-92pzqj35	47	17	;	;	:
cord-002248-92pzqj35	47	18	it	-PRON-	PRP
cord-002248-92pzqj35	47	19	has	have	VBZ
cord-002248-92pzqj35	47	20	been	be	VBN
cord-002248-92pzqj35	47	21	proposed	propose	VBN
cord-002248-92pzqj35	47	22	that	that	IN
cord-002248-92pzqj35	47	23	NSs	NSs	NNP
cord-002248-92pzqj35	47	24	exerts	exert	VBZ
cord-002248-92pzqj35	47	25	suppression	suppression	NN
cord-002248-92pzqj35	47	26	of	of	IN
cord-002248-92pzqj35	47	27	general	general	JJ
cord-002248-92pzqj35	47	28	transcription	transcription	NN
cord-002248-92pzqj35	47	29	by	by	IN
cord-002248-92pzqj35	47	30	interacting	interact	VBG
cord-002248-92pzqj35	47	31	with	with	IN
cord-002248-92pzqj35	47	32	subunits	subunit	NNS
cord-002248-92pzqj35	47	33	of	of	IN
cord-002248-92pzqj35	47	34	transcription	transcription	NN
cord-002248-92pzqj35	47	35	factor	factor	NN
cord-002248-92pzqj35	47	36	II	II	NNP
cord-002248-92pzqj35	47	37	H	H	NNP
cord-002248-92pzqj35	47	38	(	(	-LRB-
cord-002248-92pzqj35	47	39	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	47	40	)	)	-RRB-
cord-002248-92pzqj35	47	41	complex	complex	NN
cord-002248-92pzqj35	47	42	,	,	,
cord-002248-92pzqj35	47	43	p44	p44	NN
cord-002248-92pzqj35	47	44	and	and	CC
cord-002248-92pzqj35	47	45	p62	p62	NN
cord-002248-92pzqj35	47	46	[	[	-LRB-
cord-002248-92pzqj35	47	47	12	12	CD
cord-002248-92pzqj35	47	48	,	,	,
cord-002248-92pzqj35	47	49	13	13	CD
cord-002248-92pzqj35	47	50	]	]	-RRB-
cord-002248-92pzqj35	47	51	.	.	.
cord-002248-92pzqj35	48	1	A	a	DT
cord-002248-92pzqj35	48	2	recent	recent	JJ
cord-002248-92pzqj35	48	3	study	study	NN
cord-002248-92pzqj35	48	4	showed	show	VBD
cord-002248-92pzqj35	48	5	that	that	IN
cord-002248-92pzqj35	48	6	the	the	DT
cord-002248-92pzqj35	48	7	NSs	NSs	NNP
cord-002248-92pzqj35	48	8	-	-	HYPH
cord-002248-92pzqj35	48	9	mediated	mediate	VBN
cord-002248-92pzqj35	48	10	general	general	JJ
cord-002248-92pzqj35	48	11	transcription	transcription	NN
cord-002248-92pzqj35	48	12	inhibition	inhibition	NN
cord-002248-92pzqj35	48	13	contributes	contribute	VBZ
cord-002248-92pzqj35	48	14	to	to	IN
cord-002248-92pzqj35	48	15	the	the	DT
cord-002248-92pzqj35	48	16	inhibition	inhibition	NN
cord-002248-92pzqj35	48	17	of	of	IN
cord-002248-92pzqj35	48	18	IFN	IFN	NNP
cord-002248-92pzqj35	48	19	-	-	HYPH
cord-002248-92pzqj35	48	20	β	β	NNP
cord-002248-92pzqj35	48	21	mRNA	mrna	NN
cord-002248-92pzqj35	48	22	transcription	transcription	NN
cord-002248-92pzqj35	48	23	[	[	-LRB-
cord-002248-92pzqj35	48	24	14	14	CD
cord-002248-92pzqj35	48	25	]	]	-RRB-
cord-002248-92pzqj35	48	26	.	.	.
cord-002248-92pzqj35	49	1	Although	although	IN
cord-002248-92pzqj35	49	2	NSs	ns	NNS
cord-002248-92pzqj35	49	3	-	-	HYPH
cord-002248-92pzqj35	49	4	mediated	mediate	VBN
cord-002248-92pzqj35	49	5	transcription	transcription	NN
cord-002248-92pzqj35	49	6	suppression	suppression	NN
cord-002248-92pzqj35	49	7	has	have	VBZ
cord-002248-92pzqj35	49	8	been	be	VBN
cord-002248-92pzqj35	49	9	considered	consider	VBN
cord-002248-92pzqj35	49	10	to	to	TO
cord-002248-92pzqj35	49	11	be	be	VB
cord-002248-92pzqj35	49	12	important	important	JJ
cord-002248-92pzqj35	49	13	in	in	IN
cord-002248-92pzqj35	49	14	suppressing	suppress	VBG
cord-002248-92pzqj35	49	15	the	the	DT
cord-002248-92pzqj35	49	16	host	host	NN
cord-002248-92pzqj35	49	17	antiviral	antiviral	JJ
cord-002248-92pzqj35	49	18	response	response	NN
cord-002248-92pzqj35	49	19	,	,	,
cord-002248-92pzqj35	49	20	the	the	DT
cord-002248-92pzqj35	49	21	exact	exact	JJ
cord-002248-92pzqj35	49	22	effects	effect	NNS
cord-002248-92pzqj35	49	23	of	of	IN
cord-002248-92pzqj35	49	24	the	the	DT
cord-002248-92pzqj35	49	25	NSs	NSs	NNP
cord-002248-92pzqj35	49	26	-	-	HYPH
cord-002248-92pzqj35	49	27	mediated	mediate	VBN
cord-002248-92pzqj35	49	28	general	general	JJ
cord-002248-92pzqj35	49	29	transcription	transcription	NN
cord-002248-92pzqj35	49	30	inhibition	inhibition	NN
cord-002248-92pzqj35	49	31	on	on	IN
cord-002248-92pzqj35	49	32	virus	virus	NN
cord-002248-92pzqj35	49	33	virulence	virulence	NN
cord-002248-92pzqj35	49	34	have	have	VBP
cord-002248-92pzqj35	49	35	not	not	RB
cord-002248-92pzqj35	49	36	been	be	VBN
cord-002248-92pzqj35	49	37	defined	define	VBN
cord-002248-92pzqj35	49	38	.	.	.
cord-002248-92pzqj35	50	1	NSs	NSs	NNP
cord-002248-92pzqj35	50	2	promotes	promote	VBZ
cord-002248-92pzqj35	50	3	the	the	DT
cord-002248-92pzqj35	50	4	degradation	degradation	NN
cord-002248-92pzqj35	50	5	of	of	IN
cord-002248-92pzqj35	50	6	doublestranded	doublestranded	NNP
cord-002248-92pzqj35	50	7	RNA	RNA	NNP
cord-002248-92pzqj35	50	8	-	-	HYPH
cord-002248-92pzqj35	50	9	dependent	dependent	JJ
cord-002248-92pzqj35	50	10	protein	protein	NN
cord-002248-92pzqj35	50	11	kinase	kinase	NN
cord-002248-92pzqj35	50	12	R	r	NN
cord-002248-92pzqj35	50	13	(	(	-LRB-
cord-002248-92pzqj35	50	14	PKR	PKR	NNP
cord-002248-92pzqj35	50	15	)	)	-RRB-
cord-002248-92pzqj35	50	16	,	,	,
cord-002248-92pzqj35	50	17	an	an	DT
cord-002248-92pzqj35	50	18	antiviral	antiviral	JJ
cord-002248-92pzqj35	50	19	IFN	IFN	NNP
cord-002248-92pzqj35	50	20	-	-	HYPH
cord-002248-92pzqj35	50	21	stimulated	stimulate	VBN
cord-002248-92pzqj35	50	22	gene	gene	NN
cord-002248-92pzqj35	50	23	product	product	NN
cord-002248-92pzqj35	50	24	,	,	,
cord-002248-92pzqj35	50	25	through	through	IN
cord-002248-92pzqj35	50	26	a	a	DT
cord-002248-92pzqj35	50	27	proteasome	proteasome	VBN
cord-002248-92pzqj35	50	28	pathway	pathway	NN
cord-002248-92pzqj35	50	29	to	to	TO
cord-002248-92pzqj35	50	30	prevent	prevent	VB
cord-002248-92pzqj35	50	31	phosphorylation	phosphorylation	NN
cord-002248-92pzqj35	50	32	of	of	IN
cord-002248-92pzqj35	50	33	eIF2-α	eif2-α	NN
cord-002248-92pzqj35	50	34	triggered	trigger	VBN
cord-002248-92pzqj35	50	35	by	by	IN
cord-002248-92pzqj35	50	36	RVFV	RVFV	NNP
cord-002248-92pzqj35	50	37	infection	infection	NN
cord-002248-92pzqj35	50	38	[	[	-LRB-
cord-002248-92pzqj35	50	39	15	15	CD
cord-002248-92pzqj35	50	40	]	]	-RRB-
cord-002248-92pzqj35	50	41	[	[	-LRB-
cord-002248-92pzqj35	50	42	16	16	CD
cord-002248-92pzqj35	50	43	]	]	-RRB-
cord-002248-92pzqj35	50	44	[	[	-LRB-
cord-002248-92pzqj35	50	45	17	17	CD
cord-002248-92pzqj35	50	46	]	]	-RRB-
cord-002248-92pzqj35	50	47	[	[	-LRB-
cord-002248-92pzqj35	50	48	18	18	CD
cord-002248-92pzqj35	50	49	]	]	-RRB-
cord-002248-92pzqj35	50	50	.	.	.
cord-002248-92pzqj35	51	1	Furthermore	furthermore	RB
cord-002248-92pzqj35	51	2	,	,	,
cord-002248-92pzqj35	51	3	NSs	NSs	NNP
cord-002248-92pzqj35	51	4	contributes	contribute	VBZ
cord-002248-92pzqj35	51	5	to	to	IN
cord-002248-92pzqj35	51	6	cellular	cellular	JJ
cord-002248-92pzqj35	51	7	stress	stress	NN
cord-002248-92pzqj35	51	8	responses	response	NNS
cord-002248-92pzqj35	51	9	such	such	JJ
cord-002248-92pzqj35	51	10	as	as	IN
cord-002248-92pzqj35	51	11	an	an	DT
cord-002248-92pzqj35	51	12	increase	increase	NN
cord-002248-92pzqj35	51	13	in	in	IN
cord-002248-92pzqj35	51	14	reactive	reactive	JJ
cord-002248-92pzqj35	51	15	oxygen	oxygen	NN
cord-002248-92pzqj35	51	16	species	specie	NNS
cord-002248-92pzqj35	51	17	,	,	,
cord-002248-92pzqj35	51	18	activation	activation	NN
cord-002248-92pzqj35	51	19	of	of	IN
cord-002248-92pzqj35	51	20	DNA	dna	NN
cord-002248-92pzqj35	51	21	damage	damage	NN
cord-002248-92pzqj35	51	22	signaling	signaling	NN
cord-002248-92pzqj35	51	23	,	,	,
cord-002248-92pzqj35	51	24	cell	cell	NN
cord-002248-92pzqj35	51	25	cycle	cycle	NN
cord-002248-92pzqj35	51	26	arrest	arrest	NN
cord-002248-92pzqj35	51	27	,	,	,
cord-002248-92pzqj35	51	28	and	and	CC
cord-002248-92pzqj35	51	29	activation	activation	NN
cord-002248-92pzqj35	51	30	of	of	IN
cord-002248-92pzqj35	51	31	the	the	DT
cord-002248-92pzqj35	51	32	p53	p53	NN
cord-002248-92pzqj35	51	33	signaling	signal	VBG
cord-002248-92pzqj35	51	34	pathway	pathway	NN
cord-002248-92pzqj35	51	35	[	[	-LRB-
cord-002248-92pzqj35	51	36	19	19	CD
cord-002248-92pzqj35	51	37	]	]	-RRB-
cord-002248-92pzqj35	51	38	[	[	-LRB-
cord-002248-92pzqj35	51	39	20	20	CD
cord-002248-92pzqj35	51	40	]	]	-RRB-
cord-002248-92pzqj35	51	41	[	[	-LRB-
cord-002248-92pzqj35	51	42	21	21	CD
cord-002248-92pzqj35	51	43	]	]	-RRB-
cord-002248-92pzqj35	51	44	[	[	-LRB-
cord-002248-92pzqj35	51	45	22	22	CD
cord-002248-92pzqj35	51	46	]	]	-RRB-
cord-002248-92pzqj35	51	47	.	.	.
cord-002248-92pzqj35	52	1	Although	although	IN
cord-002248-92pzqj35	52	2	how	how	WRB
cord-002248-92pzqj35	52	3	NSs	NSs	NNP
cord-002248-92pzqj35	52	4	induces	induce	VBZ
cord-002248-92pzqj35	52	5	the	the	DT
cord-002248-92pzqj35	52	6	cellular	cellular	JJ
cord-002248-92pzqj35	52	7	stresses	stress	NNS
cord-002248-92pzqj35	52	8	remains	remain	VBZ
cord-002248-92pzqj35	52	9	largely	largely	RB
cord-002248-92pzqj35	52	10	unknown	unknown	JJ
cord-002248-92pzqj35	52	11	,	,	,
cord-002248-92pzqj35	52	12	these	these	DT
cord-002248-92pzqj35	52	13	stress	stress	NN
cord-002248-92pzqj35	52	14	responses	response	NNS
cord-002248-92pzqj35	52	15	may	may	MD
cord-002248-92pzqj35	52	16	contribute	contribute	VB
cord-002248-92pzqj35	52	17	to	to	IN
cord-002248-92pzqj35	52	18	RVFV	RVFV	NNP
cord-002248-92pzqj35	52	19	-	-	HYPH
cord-002248-92pzqj35	52	20	induced	induce	VBN
cord-002248-92pzqj35	52	21	cell	cell	NN
cord-002248-92pzqj35	52	22	death	death	NN
cord-002248-92pzqj35	52	23	.	.	.
cord-002248-92pzqj35	53	1	To	to	TO
cord-002248-92pzqj35	53	2	elucidate	elucidate	VB
cord-002248-92pzqj35	53	3	the	the	DT
cord-002248-92pzqj35	53	4	mechanisms	mechanism	NNS
cord-002248-92pzqj35	53	5	of	of	IN
cord-002248-92pzqj35	53	6	the	the	DT
cord-002248-92pzqj35	53	7	different	different	JJ
cord-002248-92pzqj35	53	8	functions	function	NNS
cord-002248-92pzqj35	53	9	of	of	IN
cord-002248-92pzqj35	53	10	NSs	NSs	NNP
cord-002248-92pzqj35	53	11	,	,	,
cord-002248-92pzqj35	53	12	it	-PRON-	PRP
cord-002248-92pzqj35	53	13	would	would	MD
cord-002248-92pzqj35	53	14	be	be	VB
cord-002248-92pzqj35	53	15	of	of	IN
cord-002248-92pzqj35	53	16	great	great	JJ
cord-002248-92pzqj35	53	17	value	value	NN
cord-002248-92pzqj35	53	18	to	to	TO
cord-002248-92pzqj35	53	19	characterize	characterize	VB
cord-002248-92pzqj35	53	20	a	a	DT
cord-002248-92pzqj35	53	21	series	series	NN
cord-002248-92pzqj35	53	22	of	of	IN
cord-002248-92pzqj35	53	23	NSs	NSs	NNP
cord-002248-92pzqj35	53	24	mutants	mutant	NNS
cord-002248-92pzqj35	53	25	,	,	,
cord-002248-92pzqj35	53	26	each	each	DT
cord-002248-92pzqj35	53	27	of	of	IN
cord-002248-92pzqj35	53	28	which	which	WDT
cord-002248-92pzqj35	53	29	specifically	specifically	RB
cord-002248-92pzqj35	53	30	lacks	lack	VBZ
cord-002248-92pzqj35	53	31	one	one	CD
cord-002248-92pzqj35	53	32	of	of	IN
cord-002248-92pzqj35	53	33	these	these	DT
cord-002248-92pzqj35	53	34	NSs	NSs	NNP
cord-002248-92pzqj35	53	35	functions	function	NNS
cord-002248-92pzqj35	53	36	but	but	CC
cord-002248-92pzqj35	53	37	retains	retain	VBZ
cord-002248-92pzqj35	53	38	other	other	JJ
cord-002248-92pzqj35	53	39	functions	function	NNS
cord-002248-92pzqj35	53	40	.	.	.
cord-002248-92pzqj35	54	1	However	however	RB
cord-002248-92pzqj35	54	2	,	,	,
cord-002248-92pzqj35	54	3	introducing	introduce	VBG
cord-002248-92pzqj35	54	4	any	any	DT
cord-002248-92pzqj35	54	5	short	short	JJ
cord-002248-92pzqj35	54	6	in	in	IN
cord-002248-92pzqj35	54	7	-	-	HYPH
cord-002248-92pzqj35	54	8	frame	frame	NN
cord-002248-92pzqj35	54	9	deletion	deletion	NN
cord-002248-92pzqj35	54	10	in	in	IN
cord-002248-92pzqj35	54	11	the	the	DT
cord-002248-92pzqj35	54	12	RVFV	RVFV	NNP
cord-002248-92pzqj35	54	13	NSs	NSs	NNP
cord-002248-92pzqj35	54	14	resulted	result	VBD
cord-002248-92pzqj35	54	15	in	in	IN
cord-002248-92pzqj35	54	16	loss	loss	NN
cord-002248-92pzqj35	54	17	of	of	IN
cord-002248-92pzqj35	54	18	all	all	DT
cord-002248-92pzqj35	54	19	functions	function	NNS
cord-002248-92pzqj35	54	20	[	[	-LRB-
cord-002248-92pzqj35	54	21	23	23	CD
cord-002248-92pzqj35	54	22	]	]	-RRB-
cord-002248-92pzqj35	54	23	,	,	,
cord-002248-92pzqj35	54	24	suggesting	suggest	VBG
cord-002248-92pzqj35	54	25	to	to	IN
cord-002248-92pzqj35	54	26	us	-PRON-	PRP
cord-002248-92pzqj35	54	27	that	that	IN
cord-002248-92pzqj35	54	28	the	the	DT
cord-002248-92pzqj35	54	29	NSs	NSs	NNP
cord-002248-92pzqj35	54	30	protein	protein	NN
cord-002248-92pzqj35	54	31	structure	structure	NN
cord-002248-92pzqj35	54	32	is	be	VBZ
cord-002248-92pzqj35	54	33	important	important	JJ
cord-002248-92pzqj35	54	34	for	for	IN
cord-002248-92pzqj35	54	35	its	-PRON-	PRP$
cord-002248-92pzqj35	54	36	biological	biological	JJ
cord-002248-92pzqj35	54	37	activity	activity	NN
cord-002248-92pzqj35	54	38	.	.	.
cord-002248-92pzqj35	55	1	Hence	hence	RB
cord-002248-92pzqj35	55	2	,	,	,
cord-002248-92pzqj35	55	3	it	-PRON-	PRP
cord-002248-92pzqj35	55	4	has	have	VBZ
cord-002248-92pzqj35	55	5	been	be	VBN
cord-002248-92pzqj35	55	6	challenging	challenge	VBG
cord-002248-92pzqj35	55	7	to	to	TO
cord-002248-92pzqj35	55	8	generate	generate	VB
cord-002248-92pzqj35	55	9	NSs	nss	NN
cord-002248-92pzqj35	55	10	mutants	mutant	NNS
cord-002248-92pzqj35	55	11	that	that	WDT
cord-002248-92pzqj35	55	12	lack	lack	VBP
cord-002248-92pzqj35	55	13	a	a	DT
cord-002248-92pzqj35	55	14	specific	specific	JJ
cord-002248-92pzqj35	55	15	biological	biological	JJ
cord-002248-92pzqj35	55	16	function	function	NN
cord-002248-92pzqj35	55	17	but	but	CC
cord-002248-92pzqj35	55	18	retain	retain	VB
cord-002248-92pzqj35	55	19	its	-PRON-	PRP$
cord-002248-92pzqj35	55	20	other	other	JJ
cord-002248-92pzqj35	55	21	functions	function	NNS
cord-002248-92pzqj35	55	22	.	.	.
cord-002248-92pzqj35	56	1	The	the	DT
cord-002248-92pzqj35	56	2	lack	lack	NN
cord-002248-92pzqj35	56	3	of	of	IN
cord-002248-92pzqj35	56	4	these	these	DT
cord-002248-92pzqj35	56	5	NSs	NSs	NNP
cord-002248-92pzqj35	56	6	mutants	mutant	NNS
cord-002248-92pzqj35	56	7	has	have	VBZ
cord-002248-92pzqj35	56	8	prevented	prevent	VBN
cord-002248-92pzqj35	56	9	a	a	DT
cord-002248-92pzqj35	56	10	detailed	detailed	JJ
cord-002248-92pzqj35	56	11	mechanistic	mechanistic	JJ
cord-002248-92pzqj35	56	12	analysis	analysis	NN
cord-002248-92pzqj35	56	13	of	of	IN
cord-002248-92pzqj35	56	14	each	each	DT
cord-002248-92pzqj35	56	15	biological	biological	JJ
cord-002248-92pzqj35	56	16	function	function	NN
cord-002248-92pzqj35	56	17	of	of	IN
cord-002248-92pzqj35	56	18	the	the	DT
cord-002248-92pzqj35	56	19	NSs	NSs	NNP
cord-002248-92pzqj35	56	20	.	.	.
cord-002248-92pzqj35	57	1	In	in	IN
cord-002248-92pzqj35	57	2	this	this	DT
cord-002248-92pzqj35	57	3	study	study	NN
cord-002248-92pzqj35	57	4	,	,	,
cord-002248-92pzqj35	57	5	we	-PRON-	PRP
cord-002248-92pzqj35	57	6	generated	generate	VBD
cord-002248-92pzqj35	57	7	two	two	CD
cord-002248-92pzqj35	57	8	RVFV	RVFV	NNP
cord-002248-92pzqj35	57	9	mutants	mutant	NNS
cord-002248-92pzqj35	57	10	,	,	,
cord-002248-92pzqj35	57	11	each	each	DT
cord-002248-92pzqj35	57	12	carrying	carry	VBG
cord-002248-92pzqj35	57	13	mutations	mutation	NNS
cord-002248-92pzqj35	57	14	in	in	IN
cord-002248-92pzqj35	57	15	NSs	NSs	NNP
cord-002248-92pzqj35	57	16	,	,	,
cord-002248-92pzqj35	57	17	that	that	WDT
cord-002248-92pzqj35	57	18	specifically	specifically	RB
cord-002248-92pzqj35	57	19	targeted	target	VBD
cord-002248-92pzqj35	57	20	its	-PRON-	PRP$
cord-002248-92pzqj35	57	21	general	general	JJ
cord-002248-92pzqj35	57	22	transcription	transcription	NN
cord-002248-92pzqj35	57	23	inhibition	inhibition	NN
cord-002248-92pzqj35	57	24	function	function	NN
cord-002248-92pzqj35	57	25	,	,	,
cord-002248-92pzqj35	57	26	to	to	TO
cord-002248-92pzqj35	57	27	delineate	delineate	VB
cord-002248-92pzqj35	57	28	the	the	DT
cord-002248-92pzqj35	57	29	mechanism	mechanism	NN
cord-002248-92pzqj35	57	30	of	of	IN
cord-002248-92pzqj35	57	31	its	-PRON-	PRP$
cord-002248-92pzqj35	57	32	inhibition	inhibition	NN
cord-002248-92pzqj35	57	33	by	by	IN
cord-002248-92pzqj35	57	34	NSs	NSs	NNP
cord-002248-92pzqj35	57	35	.	.	.
cord-002248-92pzqj35	58	1	Furthermore	furthermore	RB
cord-002248-92pzqj35	58	2	,	,	,
cord-002248-92pzqj35	58	3	we	-PRON-	PRP
cord-002248-92pzqj35	58	4	examined	examine	VBD
cord-002248-92pzqj35	58	5	the	the	DT
cord-002248-92pzqj35	58	6	importance	importance	NN
cord-002248-92pzqj35	58	7	of	of	IN
cord-002248-92pzqj35	58	8	the	the	DT
cord-002248-92pzqj35	58	9	NSs	NSs	NNP
cord-002248-92pzqj35	58	10	-	-	HYPH
cord-002248-92pzqj35	58	11	mediated	mediate	VBN
cord-002248-92pzqj35	58	12	inhibition	inhibition	NN
cord-002248-92pzqj35	58	13	of	of	IN
cord-002248-92pzqj35	58	14	general	general	JJ
cord-002248-92pzqj35	58	15	transcription	transcription	NN
cord-002248-92pzqj35	58	16	on	on	IN
cord-002248-92pzqj35	58	17	virus	virus	NN
cord-002248-92pzqj35	58	18	-	-	HYPH
cord-002248-92pzqj35	58	19	induced	induce	VBN
cord-002248-92pzqj35	58	20	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	58	21	and	and	CC
cord-002248-92pzqj35	58	22	tested	test	VBD
cord-002248-92pzqj35	58	23	its	-PRON-	PRP$
cord-002248-92pzqj35	58	24	role	role	NN
cord-002248-92pzqj35	58	25	in	in	IN
cord-002248-92pzqj35	58	26	RVFV	RVFV	NNP
cord-002248-92pzqj35	58	27	virulence	virulence	NN
cord-002248-92pzqj35	58	28	by	by	IN
cord-002248-92pzqj35	58	29	using	use	VBG
cord-002248-92pzqj35	58	30	a	a	DT
cord-002248-92pzqj35	58	31	young	young	JJ
cord-002248-92pzqj35	58	32	mouse	mouse	NN
cord-002248-92pzqj35	58	33	model	model	NN
cord-002248-92pzqj35	58	34	.	.	.
cord-002248-92pzqj35	59	1	All	all	DT
cord-002248-92pzqj35	59	2	mouse	mouse	NN
cord-002248-92pzqj35	59	3	studies	study	NNS
cord-002248-92pzqj35	59	4	were	be	VBD
cord-002248-92pzqj35	59	5	performed	perform	VBN
cord-002248-92pzqj35	59	6	in	in	IN
cord-002248-92pzqj35	59	7	facilities	facility	NNS
cord-002248-92pzqj35	59	8	accredited	accredit	VBN
cord-002248-92pzqj35	59	9	by	by	IN
cord-002248-92pzqj35	59	10	the	the	DT
cord-002248-92pzqj35	59	11	Association	Association	NNP
cord-002248-92pzqj35	59	12	for	for	IN
cord-002248-92pzqj35	59	13	Assessment	Assessment	NNP
cord-002248-92pzqj35	59	14	and	and	CC
cord-002248-92pzqj35	59	15	Accreditation	Accreditation	NNP
cord-002248-92pzqj35	59	16	of	of	IN
cord-002248-92pzqj35	59	17	Laboratory	Laboratory	NNP
cord-002248-92pzqj35	59	18	Animal	Animal	NNP
cord-002248-92pzqj35	59	19	Care	Care	NNP
cord-002248-92pzqj35	59	20	in	in	IN
cord-002248-92pzqj35	59	21	accordance	accordance	NN
cord-002248-92pzqj35	59	22	with	with	IN
cord-002248-92pzqj35	59	23	the	the	DT
cord-002248-92pzqj35	59	24	recommendations	recommendation	NNS
cord-002248-92pzqj35	59	25	in	in	IN
cord-002248-92pzqj35	59	26	the	the	DT
cord-002248-92pzqj35	59	27	Guide	Guide	NNP
cord-002248-92pzqj35	59	28	for	for	IN
cord-002248-92pzqj35	59	29	the	the	DT
cord-002248-92pzqj35	59	30	Care	Care	NNP
cord-002248-92pzqj35	59	31	and	and	CC
cord-002248-92pzqj35	59	32	Use	Use	NNP
cord-002248-92pzqj35	59	33	of	of	IN
cord-002248-92pzqj35	59	34	Laboratory	Laboratory	NNP
cord-002248-92pzqj35	59	35	Animals	Animals	NNPS
cord-002248-92pzqj35	59	36	(	(	-LRB-
cord-002248-92pzqj35	59	37	Institute	Institute	NNP
cord-002248-92pzqj35	59	38	of	of	IN
cord-002248-92pzqj35	59	39	Laboratory	Laboratory	NNP
cord-002248-92pzqj35	59	40	Animal	Animal	NNP
cord-002248-92pzqj35	59	41	Resources	Resources	NNPS
cord-002248-92pzqj35	59	42	,	,	,
cord-002248-92pzqj35	59	43	National	National	NNP
cord-002248-92pzqj35	59	44	Research	Research	NNP
cord-002248-92pzqj35	59	45	Council	Council	NNP
cord-002248-92pzqj35	59	46	,	,	,
cord-002248-92pzqj35	59	47	National	National	NNP
cord-002248-92pzqj35	59	48	Academy	Academy	NNP
cord-002248-92pzqj35	59	49	of	of	IN
cord-002248-92pzqj35	59	50	Sciences	Sciences	NNPS
cord-002248-92pzqj35	59	51	,	,	,
cord-002248-92pzqj35	59	52	1996	1996	CD
cord-002248-92pzqj35	59	53	)	)	-RRB-
cord-002248-92pzqj35	59	54	.	.	.
cord-002248-92pzqj35	60	1	The	the	DT
cord-002248-92pzqj35	60	2	animal	animal	NN
cord-002248-92pzqj35	60	3	protocol	protocol	NN
cord-002248-92pzqj35	60	4	(	(	-LRB-
cord-002248-92pzqj35	60	5	protocol	protocol	NN
cord-002248-92pzqj35	60	6	number	number	NN
cord-002248-92pzqj35	60	7	,	,	,
cord-002248-92pzqj35	60	8	1105023A	1105023A	NNP
cord-002248-92pzqj35	60	9	)	)	-RRB-
cord-002248-92pzqj35	60	10	was	be	VBD
cord-002248-92pzqj35	60	11	approved	approve	VBN
cord-002248-92pzqj35	60	12	by	by	IN
cord-002248-92pzqj35	60	13	the	the	DT
cord-002248-92pzqj35	60	14	Institutional	Institutional	NNP
cord-002248-92pzqj35	60	15	Animal	Animal	NNP
cord-002248-92pzqj35	60	16	Care	Care	NNP
cord-002248-92pzqj35	60	17	and	and	CC
cord-002248-92pzqj35	60	18	Use	Use	NNP
cord-002248-92pzqj35	60	19	Committee	Committee	NNP
cord-002248-92pzqj35	60	20	of	of	IN
cord-002248-92pzqj35	60	21	The	the	DT
cord-002248-92pzqj35	60	22	University	University	NNP
cord-002248-92pzqj35	60	23	of	of	IN
cord-002248-92pzqj35	60	24	Texas	Texas	NNP
cord-002248-92pzqj35	60	25	Medical	Medical	NNP
cord-002248-92pzqj35	60	26	Branch	Branch	NNP
cord-002248-92pzqj35	60	27	.	.	.
cord-002248-92pzqj35	61	1	A	a	DT
cord-002248-92pzqj35	61	2	standard	standard	JJ
cord-002248-92pzqj35	61	3	recombinant	recombinant	JJ
cord-002248-92pzqj35	61	4	PCR	pcr	NN
cord-002248-92pzqj35	61	5	method	method	NN
cord-002248-92pzqj35	61	6	,	,	,
cord-002248-92pzqj35	61	7	in	in	IN
cord-002248-92pzqj35	61	8	which	which	WDT
cord-002248-92pzqj35	61	9	pProT7-S	pProT7-S	NNP
cord-002248-92pzqj35	61	10	encoding	encode	VBG
cord-002248-92pzqj35	61	11	antiviral	antiviral	JJ
cord-002248-92pzqj35	61	12	-	-	HYPH
cord-002248-92pzqj35	61	13	sense	sense	NN
cord-002248-92pzqj35	61	14	S	S	NNP
cord-002248-92pzqj35	61	15	RNA	RNA	NNP
cord-002248-92pzqj35	61	16	[	[	-LRB-
cord-002248-92pzqj35	61	17	24	24	CD
cord-002248-92pzqj35	61	18	]	]	-RRB-
cord-002248-92pzqj35	61	19	served	serve	VBD
cord-002248-92pzqj35	61	20	as	as	IN
cord-002248-92pzqj35	61	21	a	a	DT
cord-002248-92pzqj35	61	22	template	template	NN
cord-002248-92pzqj35	61	23	,	,	,
cord-002248-92pzqj35	61	24	was	be	VBD
cord-002248-92pzqj35	61	25	used	use	VBN
cord-002248-92pzqj35	61	26	to	to	TO
cord-002248-92pzqj35	61	27	generate	generate	VB
cord-002248-92pzqj35	61	28	pProT7-S	pProT7-S	NNP
cord-002248-92pzqj35	61	29	carrying	carrying	NN
cord-002248-92pzqj35	61	30	mutations	mutation	NNS
cord-002248-92pzqj35	61	31	in	in	IN
cord-002248-92pzqj35	61	32	NSs	NSs	NNP
cord-002248-92pzqj35	61	33	coding	code	VBG
cord-002248-92pzqj35	61	34	region	region	NN
cord-002248-92pzqj35	61	35	.	.	.
cord-002248-92pzqj35	62	1	The	the	DT
cord-002248-92pzqj35	62	2	NSs	NSs	NNP
cord-002248-92pzqj35	62	3	coding	code	VBG
cord-002248-92pzqj35	62	4	region	region	NN
cord-002248-92pzqj35	62	5	of	of	IN
cord-002248-92pzqj35	62	6	pProT7-S	pProT7-S	NNP
cord-002248-92pzqj35	62	7	was	be	VBD
cord-002248-92pzqj35	62	8	amplified	amplify	VBN
cord-002248-92pzqj35	62	9	by	by	IN
cord-002248-92pzqj35	62	10	using	use	VBG
cord-002248-92pzqj35	62	11	primers	primer	NNS
cord-002248-92pzqj35	62	12	carrying	carry	VBG
cord-002248-92pzqj35	62	13	Mfe	Mfe	NNP
cord-002248-92pzqj35	62	14	I	-PRON-	PRP
cord-002248-92pzqj35	62	15	or	or	CC
cord-002248-92pzqj35	62	16	a	a	DT
cord-002248-92pzqj35	62	17	Not	not	RB
cord-002248-92pzqj35	62	18	I	-PRON-	PRP
cord-002248-92pzqj35	62	19	site	site	NN
cord-002248-92pzqj35	62	20	.	.	.
cord-002248-92pzqj35	63	1	After	after	IN
cord-002248-92pzqj35	63	2	digestion	digestion	NN
cord-002248-92pzqj35	63	3	with	with	IN
cord-002248-92pzqj35	63	4	Mfe	Mfe	NNP
cord-002248-92pzqj35	63	5	I	-PRON-	PRP
cord-002248-92pzqj35	63	6	and	and	CC
cord-002248-92pzqj35	63	7	Not	not	RB
cord-002248-92pzqj35	63	8	I	-PRON-	PRP
cord-002248-92pzqj35	63	9	,	,	,
cord-002248-92pzqj35	63	10	the	the	DT
cord-002248-92pzqj35	63	11	PCR	PCR	NNP
cord-002248-92pzqj35	63	12	fragment	fragment	NN
cord-002248-92pzqj35	63	13	was	be	VBD
cord-002248-92pzqj35	63	14	cloned	clone	VBN
cord-002248-92pzqj35	63	15	into	into	IN
cord-002248-92pzqj35	63	16	Eco	Eco	NNP
cord-002248-92pzqj35	63	17	RI	RI	NNP
cord-002248-92pzqj35	63	18	and	and	CC
cord-002248-92pzqj35	63	19	the	the	DT
cord-002248-92pzqj35	63	20	Not	not	RB
cord-002248-92pzqj35	63	21	I	-PRON-	PRP
cord-002248-92pzqj35	63	22	site	site	NN
cord-002248-92pzqj35	63	23	of	of	IN
cord-002248-92pzqj35	63	24	a	a	DT
cord-002248-92pzqj35	63	25	pCAGGS	pcaggs	NN
cord-002248-92pzqj35	63	26	plasmid	plasmid	NN
cord-002248-92pzqj35	63	27	,	,	,
cord-002248-92pzqj35	63	28	resulting	result	VBG
cord-002248-92pzqj35	63	29	in	in	IN
cord-002248-92pzqj35	63	30	the	the	DT
cord-002248-92pzqj35	63	31	plasmids	plasmid	NNS
cord-002248-92pzqj35	63	32	expressing	express	VBG
cord-002248-92pzqj35	63	33	NSs	NSs	NNP
cord-002248-92pzqj35	63	34	protein	protein	NN
cord-002248-92pzqj35	63	35	.	.	.
cord-002248-92pzqj35	64	1	For	for	IN
cord-002248-92pzqj35	64	2	expression	expression	NN
cord-002248-92pzqj35	64	3	of	of	IN
cord-002248-92pzqj35	64	4	human	human	JJ
cord-002248-92pzqj35	64	5	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	64	6	isoform	isoform	NN
cord-002248-92pzqj35	64	7	1	1	CD
cord-002248-92pzqj35	64	8	(	(	-LRB-
cord-002248-92pzqj35	64	9	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	64	10	)	)	-RRB-
cord-002248-92pzqj35	64	11	[	[	-LRB-
cord-002248-92pzqj35	64	12	14	14	CD
cord-002248-92pzqj35	64	13	]	]	-RRB-
cord-002248-92pzqj35	64	14	,	,	,
cord-002248-92pzqj35	64	15	intracellular	intracellular	JJ
cord-002248-92pzqj35	64	16	RNAs	rna	NNS
cord-002248-92pzqj35	64	17	of	of	IN
cord-002248-92pzqj35	64	18	MRC-5	MRC-5	NNP
cord-002248-92pzqj35	64	19	cells	cell	NNS
cord-002248-92pzqj35	64	20	were	be	VBD
cord-002248-92pzqj35	64	21	subjected	subject	VBN
cord-002248-92pzqj35	64	22	to	to	IN
cord-002248-92pzqj35	64	23	cDNA	cdna	NN
cord-002248-92pzqj35	64	24	synthesis	synthesis	NN
cord-002248-92pzqj35	64	25	,	,	,
cord-002248-92pzqj35	64	26	and	and	CC
cord-002248-92pzqj35	64	27	the	the	DT
cord-002248-92pzqj35	64	28	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	64	29	gene	gene	NN
cord-002248-92pzqj35	64	30	was	be	VBD
cord-002248-92pzqj35	64	31	amplified	amplify	VBN
cord-002248-92pzqj35	64	32	with	with	IN
cord-002248-92pzqj35	64	33	primers	primer	NNS
cord-002248-92pzqj35	64	34	carrying	carry	VBG
cord-002248-92pzqj35	64	35	Mfe	Mfe	NNP
cord-002248-92pzqj35	64	36	I	-PRON-	PRP
cord-002248-92pzqj35	64	37	or	or	CC
cord-002248-92pzqj35	64	38	the	the	DT
cord-002248-92pzqj35	64	39	Not	not	RB
cord-002248-92pzqj35	64	40	I	-PRON-	PRP
cord-002248-92pzqj35	64	41	site	site	NN
cord-002248-92pzqj35	64	42	.	.	.
cord-002248-92pzqj35	65	1	After	after	IN
cord-002248-92pzqj35	65	2	addition	addition	NN
cord-002248-92pzqj35	65	3	of	of	IN
cord-002248-92pzqj35	65	4	an	an	DT
cord-002248-92pzqj35	65	5	N	n	CD
cord-002248-92pzqj35	65	6	-	-	HYPH
cord-002248-92pzqj35	65	7	terminal	terminal	NN
cord-002248-92pzqj35	65	8	V5	v5	NN
cord-002248-92pzqj35	65	9	tag	tag	NN
cord-002248-92pzqj35	65	10	,	,	,
cord-002248-92pzqj35	65	11	the	the	DT
cord-002248-92pzqj35	65	12	PCR	PCR	NNP
cord-002248-92pzqj35	65	13	product	product	NN
cord-002248-92pzqj35	65	14	was	be	VBD
cord-002248-92pzqj35	65	15	cloned	clone	VBN
cord-002248-92pzqj35	65	16	into	into	IN
cord-002248-92pzqj35	65	17	EcoR	EcoR	NNP
cord-002248-92pzqj35	65	18	I	-PRON-	PRP
cord-002248-92pzqj35	65	19	and	and	CC
cord-002248-92pzqj35	65	20	the	the	DT
cord-002248-92pzqj35	65	21	Not	not	RB
cord-002248-92pzqj35	65	22	I	-PRON-	PRP
cord-002248-92pzqj35	65	23	site	site	NN
cord-002248-92pzqj35	65	24	of	of	IN
cord-002248-92pzqj35	65	25	pCAGGS	pCAGGS	NNP
cord-002248-92pzqj35	65	26	.	.	.
cord-002248-92pzqj35	66	1	For	for	IN
cord-002248-92pzqj35	66	2	expression	expression	NN
cord-002248-92pzqj35	66	3	of	of	IN
cord-002248-92pzqj35	66	4	human	human	JJ
cord-002248-92pzqj35	66	5	SAP30	SAP30	NNP
cord-002248-92pzqj35	66	6	,	,	,
cord-002248-92pzqj35	66	7	PCR	PCR	NNP
cord-002248-92pzqj35	66	8	product	product	NN
cord-002248-92pzqj35	66	9	encoding	encoding	NN
cord-002248-92pzqj35	66	10	human	human	NN
cord-002248-92pzqj35	66	11	SAP30	SAP30	NNP
cord-002248-92pzqj35	66	12	with	with	IN
cord-002248-92pzqj35	66	13	N	n	CD
cord-002248-92pzqj35	66	14	-	-	HYPH
cord-002248-92pzqj35	66	15	terminal	terminal	NN
cord-002248-92pzqj35	66	16	V5	v5	NN
cord-002248-92pzqj35	66	17	tag	tag	NN
cord-002248-92pzqj35	66	18	was	be	VBD
cord-002248-92pzqj35	66	19	cloned	clone	VBN
cord-002248-92pzqj35	66	20	into	into	IN
cord-002248-92pzqj35	66	21	EcoR	EcoR	NNP
cord-002248-92pzqj35	66	22	I	-PRON-	PRP
cord-002248-92pzqj35	66	23	and	and	CC
cord-002248-92pzqj35	66	24	the	the	DT
cord-002248-92pzqj35	66	25	Xho	Xho	NNP
cord-002248-92pzqj35	67	1	I	-PRON-	PRP
cord-002248-92pzqj35	67	2	site	site	NN
cord-002248-92pzqj35	67	3	of	of	IN
cord-002248-92pzqj35	67	4	pCAGGS	pCAGGS	NNP
cord-002248-92pzqj35	67	5	.	.	.
cord-002248-92pzqj35	68	1	All	all	DT
cord-002248-92pzqj35	68	2	of	of	IN
cord-002248-92pzqj35	68	3	the	the	DT
cord-002248-92pzqj35	68	4	constructs	construct	NNS
cord-002248-92pzqj35	68	5	were	be	VBD
cord-002248-92pzqj35	68	6	confirmed	confirm	VBN
cord-002248-92pzqj35	68	7	by	by	IN
cord-002248-92pzqj35	68	8	sequencing	sequence	VBG
cord-002248-92pzqj35	68	9	.	.	.
cord-002248-92pzqj35	69	1	BSR	BSR	NNP
cord-002248-92pzqj35	69	2	-	-	HYPH
cord-002248-92pzqj35	69	3	T7/5	T7/5	NNP
cord-002248-92pzqj35	69	4	cells	cell	NNS
cord-002248-92pzqj35	69	5	which	which	WDT
cord-002248-92pzqj35	69	6	stably	stably	RB
cord-002248-92pzqj35	69	7	express	express	VBP
cord-002248-92pzqj35	69	8	T7	T7	NNP
cord-002248-92pzqj35	69	9	RNA	RNA	NNP
cord-002248-92pzqj35	69	10	polymerase	polymerase	NN
cord-002248-92pzqj35	69	11	[	[	-LRB-
cord-002248-92pzqj35	69	12	25	25	CD
cord-002248-92pzqj35	69	13	]	]	-RRB-
cord-002248-92pzqj35	69	14	were	be	VBD
cord-002248-92pzqj35	69	15	maintained	maintain	VBN
cord-002248-92pzqj35	69	16	in	in	IN
cord-002248-92pzqj35	69	17	Glasgow	Glasgow	NNP
cord-002248-92pzqj35	69	18	's	's	POS
cord-002248-92pzqj35	69	19	minimal	minimal	JJ
cord-002248-92pzqj35	69	20	essential	essential	JJ
cord-002248-92pzqj35	69	21	medium	medium	NN
cord-002248-92pzqj35	69	22	(	(	-LRB-
cord-002248-92pzqj35	69	23	MEM	mem	NN
cord-002248-92pzqj35	69	24	)	)	-RRB-
cord-002248-92pzqj35	70	1	(	(	-LRB-
cord-002248-92pzqj35	70	2	Lonza	Lonza	NNP
cord-002248-92pzqj35	70	3	)	)	-RRB-
cord-002248-92pzqj35	70	4	containing	contain	VBG
cord-002248-92pzqj35	70	5	10	10	CD
cord-002248-92pzqj35	70	6	%	%	NN
cord-002248-92pzqj35	70	7	fetal	fetal	JJ
cord-002248-92pzqj35	70	8	bovine	bovine	JJ
cord-002248-92pzqj35	70	9	serum	serum	NN
cord-002248-92pzqj35	70	10	(	(	-LRB-
cord-002248-92pzqj35	70	11	FBS	FBS	NNP
cord-002248-92pzqj35	70	12	)	)	-RRB-
cord-002248-92pzqj35	70	13	,	,	,
cord-002248-92pzqj35	70	14	10	10	CD
cord-002248-92pzqj35	70	15	%	%	NN
cord-002248-92pzqj35	70	16	tryptose	tryptose	JJ
cord-002248-92pzqj35	70	17	phosphate	phosphate	NN
cord-002248-92pzqj35	70	18	broth	broth	NN
cord-002248-92pzqj35	70	19	,	,	,
cord-002248-92pzqj35	70	20	MEM	MEM	NNP
cord-002248-92pzqj35	70	21	Amino	Amino	NNP
cord-002248-92pzqj35	70	22	Acids	Acids	NNPS
cord-002248-92pzqj35	70	23	Solution	Solution	NNP
cord-002248-92pzqj35	70	24	and	and	CC
cord-002248-92pzqj35	70	25	geneticin	geneticin	NNS
cord-002248-92pzqj35	70	26	(	(	-LRB-
cord-002248-92pzqj35	70	27	1	1	CD
cord-002248-92pzqj35	70	28	mg	mg	NNP
cord-002248-92pzqj35	70	29	/	/	SYM
cord-002248-92pzqj35	70	30	ml	ml	NNP
cord-002248-92pzqj35	70	31	)	)	-RRB-
cord-002248-92pzqj35	70	32	.	.	.
cord-002248-92pzqj35	71	1	Vero	Vero	NNP
cord-002248-92pzqj35	71	2	E6	E6	NNP
cord-002248-92pzqj35	71	3	cells	cell	NNS
cord-002248-92pzqj35	71	4	were	be	VBD
cord-002248-92pzqj35	71	5	maintained	maintain	VBN
cord-002248-92pzqj35	71	6	in	in	IN
cord-002248-92pzqj35	71	7	Dulbecco	Dulbecco	NNP
cord-002248-92pzqj35	71	8	's	's	POS
cord-002248-92pzqj35	71	9	modified	modify	VBN
cord-002248-92pzqj35	71	10	MEM	mem	NN
cord-002248-92pzqj35	71	11	(	(	-LRB-
cord-002248-92pzqj35	71	12	Gibco	Gibco	NNP
cord-002248-92pzqj35	71	13	)	)	-RRB-
cord-002248-92pzqj35	71	14	containing	contain	VBG
cord-002248-92pzqj35	71	15	5	5	CD
cord-002248-92pzqj35	71	16	%	%	NN
cord-002248-92pzqj35	71	17	FBS	FBS	NNP
cord-002248-92pzqj35	71	18	.	.	.
cord-002248-92pzqj35	72	1	MRC-5	MRC-5	NNP
cord-002248-92pzqj35	72	2	cells	cell	NNS
cord-002248-92pzqj35	72	3	were	be	VBD
cord-002248-92pzqj35	72	4	maintained	maintain	VBN
cord-002248-92pzqj35	72	5	in	in	IN
cord-002248-92pzqj35	72	6	Eagle	Eagle	NNP
cord-002248-92pzqj35	72	7	's	's	POS
cord-002248-92pzqj35	72	8	MEM	mem	NN
cord-002248-92pzqj35	72	9	(	(	-LRB-
cord-002248-92pzqj35	72	10	EMEM	EMEM	NNP
cord-002248-92pzqj35	72	11	)	)	-RRB-
cord-002248-92pzqj35	73	1	(	(	-LRB-
cord-002248-92pzqj35	73	2	Gibco	Gibco	NNP
cord-002248-92pzqj35	73	3	)	)	-RRB-
cord-002248-92pzqj35	73	4	containing	contain	VBG
cord-002248-92pzqj35	73	5	10	10	CD
cord-002248-92pzqj35	73	6	%	%	NN
cord-002248-92pzqj35	73	7	FBS	FBS	NNP
cord-002248-92pzqj35	73	8	,	,	,
cord-002248-92pzqj35	73	9	MEM	MEM	NNP
cord-002248-92pzqj35	73	10	Non	Non	NNP
cord-002248-92pzqj35	73	11	-	-	JJ
cord-002248-92pzqj35	73	12	Essential	essential	JJ
cord-002248-92pzqj35	73	13	Amino	Amino	NNP
cord-002248-92pzqj35	73	14	Acids	acid	NNS
cord-002248-92pzqj35	73	15	Solution	Solution	NNP
cord-002248-92pzqj35	73	16	(	(	-LRB-
cord-002248-92pzqj35	73	17	Gibco	Gibco	NNP
cord-002248-92pzqj35	73	18	)	)	-RRB-
cord-002248-92pzqj35	73	19	,	,	,
cord-002248-92pzqj35	73	20	and	and	CC
cord-002248-92pzqj35	73	21	1	1	CD
cord-002248-92pzqj35	73	22	%	%	NN
cord-002248-92pzqj35	73	23	sodium	sodium	NN
cord-002248-92pzqj35	73	24	pyruvate	pyruvate	NN
cord-002248-92pzqj35	73	25	(	(	-LRB-
cord-002248-92pzqj35	73	26	Sigma	Sigma	NNP
cord-002248-92pzqj35	73	27	)	)	-RRB-
cord-002248-92pzqj35	73	28	.	.	.
cord-002248-92pzqj35	74	1	HeLa	HeLa	NNP
cord-002248-92pzqj35	74	2	cells	cell	NNS
cord-002248-92pzqj35	74	3	were	be	VBD
cord-002248-92pzqj35	74	4	maintained	maintain	VBN
cord-002248-92pzqj35	74	5	in	in	IN
cord-002248-92pzqj35	74	6	EMEM	EMEM	NNP
cord-002248-92pzqj35	74	7	containing	contain	VBG
cord-002248-92pzqj35	74	8	10	10	CD
cord-002248-92pzqj35	74	9	%	%	NN
cord-002248-92pzqj35	74	10	FBS	FBS	NNP
cord-002248-92pzqj35	74	11	.	.	.
cord-002248-92pzqj35	75	1	MP-12	MP-12	NNP
cord-002248-92pzqj35	75	2	is	be	VBZ
cord-002248-92pzqj35	75	3	a	a	DT
cord-002248-92pzqj35	75	4	highly	highly	RB
cord-002248-92pzqj35	75	5	attenuated	attenuate	VBN
cord-002248-92pzqj35	75	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	75	7	strain	strain	NN
cord-002248-92pzqj35	75	8	obtained	obtain	VBN
cord-002248-92pzqj35	75	9	after	after	IN
cord-002248-92pzqj35	75	10	12	12	CD
cord-002248-92pzqj35	75	11	serial	serial	JJ
cord-002248-92pzqj35	75	12	passages	passage	NNS
cord-002248-92pzqj35	75	13	of	of	IN
cord-002248-92pzqj35	75	14	an	an	DT
cord-002248-92pzqj35	75	15	RVFV	RVFV	NNP
cord-002248-92pzqj35	75	16	ZH548	ZH548	NNP
cord-002248-92pzqj35	75	17	strain	strain	NN
cord-002248-92pzqj35	75	18	in	in	IN
cord-002248-92pzqj35	75	19	the	the	DT
cord-002248-92pzqj35	75	20	presence	presence	NN
cord-002248-92pzqj35	75	21	of	of	IN
cord-002248-92pzqj35	75	22	5-fluorouracil	5-fluorouracil	CD
cord-002248-92pzqj35	75	23	[	[	-LRB-
cord-002248-92pzqj35	75	24	26	26	CD
cord-002248-92pzqj35	75	25	]	]	-RRB-
cord-002248-92pzqj35	75	26	.	.	.
cord-002248-92pzqj35	76	1	A	a	DT
cord-002248-92pzqj35	76	2	recombinant	recombinant	JJ
cord-002248-92pzqj35	76	3	MP-12	MP-12	NNP
cord-002248-92pzqj35	76	4	strain	strain	NN
cord-002248-92pzqj35	76	5	and	and	CC
cord-002248-92pzqj35	76	6	other	other	JJ
cord-002248-92pzqj35	76	7	MP-12-derived	MP-12-derived	NNP
cord-002248-92pzqj35	76	8	mutants	mutant	NNS
cord-002248-92pzqj35	76	9	were	be	VBD
cord-002248-92pzqj35	76	10	rescued	rescue	VBN
cord-002248-92pzqj35	76	11	from	from	IN
cord-002248-92pzqj35	76	12	cDNAs	cDNAs	NNPS
cord-002248-92pzqj35	76	13	as	as	IN
cord-002248-92pzqj35	76	14	described	describe	VBN
cord-002248-92pzqj35	76	15	previously	previously	RB
cord-002248-92pzqj35	76	16	[	[	-LRB-
cord-002248-92pzqj35	76	17	24	24	CD
cord-002248-92pzqj35	76	18	]	]	-RRB-
cord-002248-92pzqj35	76	19	,	,	,
cord-002248-92pzqj35	76	20	except	except	IN
cord-002248-92pzqj35	76	21	that	that	IN
cord-002248-92pzqj35	76	22	BSR	BSR	NNP
cord-002248-92pzqj35	76	23	-	-	HYPH
cord-002248-92pzqj35	76	24	T7/5	T7/5	NNP
cord-002248-92pzqj35	76	25	cells	cell	NNS
cord-002248-92pzqj35	76	26	were	be	VBD
cord-002248-92pzqj35	76	27	used	use	VBN
cord-002248-92pzqj35	76	28	in	in	IN
cord-002248-92pzqj35	76	29	place	place	NN
cord-002248-92pzqj35	76	30	of	of	IN
cord-002248-92pzqj35	76	31	BHK	BHK	NNP
cord-002248-92pzqj35	76	32	/	/	SYM
cord-002248-92pzqj35	76	33	T7	T7	NNP
cord-002248-92pzqj35	76	34	-	-	HYPH
cord-002248-92pzqj35	76	35	9	9	CD
cord-002248-92pzqj35	76	36	cells	cell	NNS
cord-002248-92pzqj35	76	37	.	.	.
cord-002248-92pzqj35	77	1	Titers	Titers	NNP
cord-002248-92pzqj35	77	2	of	of	IN
cord-002248-92pzqj35	77	3	the	the	DT
cord-002248-92pzqj35	77	4	rescued	rescue	VBN
cord-002248-92pzqj35	77	5	viruses	virus	NNS
cord-002248-92pzqj35	77	6	were	be	VBD
cord-002248-92pzqj35	77	7	determined	determine	VBN
cord-002248-92pzqj35	77	8	by	by	IN
cord-002248-92pzqj35	77	9	using	use	VBG
cord-002248-92pzqj35	77	10	a	a	DT
cord-002248-92pzqj35	77	11	plaque	plaque	NN
cord-002248-92pzqj35	77	12	assay	assay	NN
cord-002248-92pzqj35	77	13	[	[	-LRB-
cord-002248-92pzqj35	77	14	24	24	CD
cord-002248-92pzqj35	77	15	]	]	-RRB-
cord-002248-92pzqj35	77	16	.	.	.
cord-002248-92pzqj35	78	1	For	for	IN
cord-002248-92pzqj35	78	2	the	the	DT
cord-002248-92pzqj35	78	3	virus	virus	NN
cord-002248-92pzqj35	78	4	carrying	carry	VBG
cord-002248-92pzqj35	78	5	R16H/	R16H/	NNP
cord-002248-92pzqj35	78	6	M250	M250	NNP
cord-002248-92pzqj35	78	7	K	K	NNP
cord-002248-92pzqj35	78	8	mutations	mutation	NNS
cord-002248-92pzqj35	78	9	in	in	IN
cord-002248-92pzqj35	78	10	NSs	NSs	NNP
cord-002248-92pzqj35	78	11	,	,	,
cord-002248-92pzqj35	78	12	passage	passage	NN
cord-002248-92pzqj35	78	13	0	0	CD
cord-002248-92pzqj35	78	14	(	(	-LRB-
cord-002248-92pzqj35	78	15	P0	p0	NN
cord-002248-92pzqj35	78	16	)	)	-RRB-
cord-002248-92pzqj35	78	17	virus	virus	NN
cord-002248-92pzqj35	78	18	obtained	obtain	VBN
cord-002248-92pzqj35	78	19	from	from	IN
cord-002248-92pzqj35	78	20	plasmid	plasmid	NN
cord-002248-92pzqj35	78	21	-	-	HYPH
cord-002248-92pzqj35	78	22	transfected	transfecte	VBN
cord-002248-92pzqj35	78	23	BSR	BSR	NNP
cord-002248-92pzqj35	78	24	-	-	HYPH
cord-002248-92pzqj35	78	25	T7/5	T7/5	NNP
cord-002248-92pzqj35	78	26	cells	cell	NNS
cord-002248-92pzqj35	78	27	were	be	VBD
cord-002248-92pzqj35	78	28	serially	serially	RB
cord-002248-92pzqj35	78	29	diluted	dilute	VBN
cord-002248-92pzqj35	78	30	and	and	CC
cord-002248-92pzqj35	78	31	inoculated	inoculate	VBN
cord-002248-92pzqj35	78	32	into	into	IN
cord-002248-92pzqj35	78	33	VeroE6	veroe6	NN
cord-002248-92pzqj35	78	34	cells	cell	NNS
cord-002248-92pzqj35	78	35	.	.	.
cord-002248-92pzqj35	79	1	The	the	DT
cord-002248-92pzqj35	79	2	highest	high	JJS
cord-002248-92pzqj35	79	3	titer	titer	NN
cord-002248-92pzqj35	79	4	of	of	IN
cord-002248-92pzqj35	79	5	P1	P1	NNP
cord-002248-92pzqj35	79	6	virus	virus	NN
cord-002248-92pzqj35	79	7	was	be	VBD
cord-002248-92pzqj35	79	8	selected	select	VBN
cord-002248-92pzqj35	79	9	and	and	CC
cord-002248-92pzqj35	79	10	used	use	VBN
cord-002248-92pzqj35	79	11	for	for	IN
cord-002248-92pzqj35	79	12	the	the	DT
cord-002248-92pzqj35	79	13	study	study	NN
cord-002248-92pzqj35	79	14	.	.	.
cord-002248-92pzqj35	80	1	Anti	Anti	NNP
cord-002248-92pzqj35	80	2	-	-	NNP
cord-002248-92pzqj35	80	3	PKR	PKR	NNP
cord-002248-92pzqj35	80	4	rabbit	rabbit	NN
cord-002248-92pzqj35	80	5	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	80	6	antibody	antibody	NN
cord-002248-92pzqj35	80	7	,	,	,
cord-002248-92pzqj35	80	8	anti	anti	JJ
cord-002248-92pzqj35	80	9	-	-	JJ
cord-002248-92pzqj35	80	10	Flag	flag	JJ
cord-002248-92pzqj35	80	11	tag	tag	NN
cord-002248-92pzqj35	80	12	mouse	mouse	NN
cord-002248-92pzqj35	80	13	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	80	14	antibody	antibody	NN
cord-002248-92pzqj35	80	15	,	,	,
cord-002248-92pzqj35	80	16	anti	anti	JJ
cord-002248-92pzqj35	80	17	-	-	JJ
cord-002248-92pzqj35	80	18	Flag	flag	JJ
cord-002248-92pzqj35	80	19	tag	tag	NN
cord-002248-92pzqj35	80	20	rabbit	rabbit	NN
cord-002248-92pzqj35	80	21	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	80	22	antibody	antibody	NN
cord-002248-92pzqj35	80	23	,	,	,
cord-002248-92pzqj35	80	24	and	and	CC
cord-002248-92pzqj35	80	25	anti	anti	JJ
cord-002248-92pzqj35	80	26	-	-	JJ
cord-002248-92pzqj35	80	27	V5	v5	JJ
cord-002248-92pzqj35	80	28	tag	tag	NN
cord-002248-92pzqj35	80	29	rabbit	rabbit	NN
cord-002248-92pzqj35	80	30	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	80	31	antibody	antibody	NN
cord-002248-92pzqj35	80	32	were	be	VBD
cord-002248-92pzqj35	80	33	purchased	purchase	VBN
cord-002248-92pzqj35	80	34	from	from	IN
cord-002248-92pzqj35	80	35	Cell	Cell	NNP
cord-002248-92pzqj35	80	36	Signaling	Signaling	NNP
cord-002248-92pzqj35	80	37	Technology	Technology	NNP
cord-002248-92pzqj35	80	38	.	.	.
cord-002248-92pzqj35	81	1	Anti	Anti	NNP
cord-002248-92pzqj35	81	2	-	-	NNP
cord-002248-92pzqj35	81	3	GTF2H1	GTF2H1	NNP
cord-002248-92pzqj35	81	4	(	(	-LRB-
cord-002248-92pzqj35	81	5	p62	p62	NN
cord-002248-92pzqj35	81	6	)	)	-RRB-
cord-002248-92pzqj35	81	7	mouse	mouse	NN
cord-002248-92pzqj35	81	8	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	81	9	antibody	antibody	NN
cord-002248-92pzqj35	81	10	,	,	,
cord-002248-92pzqj35	81	11	anti	anti	JJ
cord-002248-92pzqj35	81	12	-	-	JJ
cord-002248-92pzqj35	81	13	GTF2H2	gtf2h2	JJ
cord-002248-92pzqj35	81	14	(	(	-LRB-
cord-002248-92pzqj35	81	15	p44	p44	NN
cord-002248-92pzqj35	81	16	)	)	-RRB-
cord-002248-92pzqj35	81	17	mouse	mouse	NN
cord-002248-92pzqj35	81	18	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	81	19	antibody	antibody	NN
cord-002248-92pzqj35	81	20	,	,	,
cord-002248-92pzqj35	81	21	and	and	CC
cord-002248-92pzqj35	81	22	anti	anti	JJ
cord-002248-92pzqj35	81	23	-	-	JJ
cord-002248-92pzqj35	81	24	XPD	XPD	NNP
cord-002248-92pzqj35	81	25	mouse	mouse	NN
cord-002248-92pzqj35	81	26	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	81	27	antibody	antibody	NN
cord-002248-92pzqj35	81	28	were	be	VBD
cord-002248-92pzqj35	81	29	purchased	purchase	VBN
cord-002248-92pzqj35	81	30	from	from	IN
cord-002248-92pzqj35	81	31	Abcam	Abcam	NNP
cord-002248-92pzqj35	81	32	.	.	.
cord-002248-92pzqj35	82	1	Anti	Anti	NNP
cord-002248-92pzqj35	82	2	-	-	JJ
cord-002248-92pzqj35	82	3	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	82	4	p44	p44	NN
cord-002248-92pzqj35	82	5	(	(	-LRB-
cord-002248-92pzqj35	82	6	N-17	N-17	NNP
cord-002248-92pzqj35	82	7	)	)	-RRB-
cord-002248-92pzqj35	83	1	goat	goat	NNP
cord-002248-92pzqj35	83	2	polyclonal	polyclonal	NNP
cord-002248-92pzqj35	83	3	antibody	antibody	NNP
cord-002248-92pzqj35	83	4	,	,	,
cord-002248-92pzqj35	83	5	anti	anti	JJ
cord-002248-92pzqj35	83	6	-	-	JJ
cord-002248-92pzqj35	83	7	β	β	JJ
cord-002248-92pzqj35	83	8	-	-	HYPH
cord-002248-92pzqj35	83	9	actin	actin	NN
cord-002248-92pzqj35	83	10	goat	goat	NN
cord-002248-92pzqj35	83	11	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	83	12	antibody	antibody	NN
cord-002248-92pzqj35	83	13	and	and	CC
cord-002248-92pzqj35	83	14	horseradish	horseradish	NN
cord-002248-92pzqj35	83	15	peroxidase	peroxidase	NN
cord-002248-92pzqj35	83	16	(	(	-LRB-
cord-002248-92pzqj35	84	1	HRP)-labeled	hrp)-labele	VBN
cord-002248-92pzqj35	85	1	anti	anti	JJ
cord-002248-92pzqj35	85	2	-	-	JJ
cord-002248-92pzqj35	85	3	mouse	mouse	JJ
cord-002248-92pzqj35	85	4	,	,	,
cord-002248-92pzqj35	85	5	anti	anti	JJ
cord-002248-92pzqj35	85	6	-	-	JJ
cord-002248-92pzqj35	85	7	goat	goat	JJ
cord-002248-92pzqj35	85	8	,	,	,
cord-002248-92pzqj35	85	9	and	and	CC
cord-002248-92pzqj35	85	10	anti	anti	JJ
cord-002248-92pzqj35	85	11	-	-	JJ
cord-002248-92pzqj35	85	12	rabbit	rabbit	JJ
cord-002248-92pzqj35	85	13	secondary	secondary	JJ
cord-002248-92pzqj35	85	14	antibodies	antibody	NNS
cord-002248-92pzqj35	85	15	were	be	VBD
cord-002248-92pzqj35	85	16	purchased	purchase	VBN
cord-002248-92pzqj35	85	17	from	from	IN
cord-002248-92pzqj35	85	18	Santa	Santa	NNP
cord-002248-92pzqj35	85	19	Cruz	Cruz	NNP
cord-002248-92pzqj35	85	20	Biotechnology	Biotechnology	NNP
cord-002248-92pzqj35	85	21	.	.	.
cord-002248-92pzqj35	86	1	Anti	anti	JJ
cord-002248-92pzqj35	86	2	-	-	NNP
cord-002248-92pzqj35	86	3	GST	GST	NNP
cord-002248-92pzqj35	86	4	-	-	HYPH
cord-002248-92pzqj35	86	5	N	n	CD
cord-002248-92pzqj35	86	6	rabbit	rabbit	NN
cord-002248-92pzqj35	86	7	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	86	8	antibody	antibody	NN
cord-002248-92pzqj35	86	9	was	be	VBD
cord-002248-92pzqj35	86	10	generated	generate	VBN
cord-002248-92pzqj35	86	11	by	by	IN
cord-002248-92pzqj35	86	12	inoculating	inoculate	VBG
cord-002248-92pzqj35	86	13	a	a	DT
cord-002248-92pzqj35	86	14	rabbit	rabbit	NN
cord-002248-92pzqj35	86	15	with	with	IN
cord-002248-92pzqj35	86	16	GST	GST	NNP
cord-002248-92pzqj35	86	17	-	-	HYPH
cord-002248-92pzqj35	86	18	N	N	NNP
cord-002248-92pzqj35	86	19	fusion	fusion	NN
cord-002248-92pzqj35	86	20	protein	protein	NN
cord-002248-92pzqj35	86	21	(	(	-LRB-
cord-002248-92pzqj35	86	22	the	the	DT
cord-002248-92pzqj35	86	23	entire	entire	JJ
cord-002248-92pzqj35	86	24	N	n	CD
cord-002248-92pzqj35	86	25	protein	protein	NN
cord-002248-92pzqj35	86	26	was	be	VBD
cord-002248-92pzqj35	86	27	fused	fuse	VBN
cord-002248-92pzqj35	86	28	with	with	IN
cord-002248-92pzqj35	86	29	the	the	DT
cord-002248-92pzqj35	86	30	C	C	NNP
cord-002248-92pzqj35	86	31	terminus	terminus	NN
cord-002248-92pzqj35	86	32	of	of	IN
cord-002248-92pzqj35	86	33	GST	GST	NNP
cord-002248-92pzqj35	86	34	protein	protein	NN
cord-002248-92pzqj35	86	35	)	)	-RRB-
cord-002248-92pzqj35	86	36	followed	follow	VBN
cord-002248-92pzqj35	86	37	by	by	IN
cord-002248-92pzqj35	86	38	affinity	affinity	NN
cord-002248-92pzqj35	86	39	purification	purification	NN
cord-002248-92pzqj35	86	40	of	of	IN
cord-002248-92pzqj35	86	41	the	the	DT
cord-002248-92pzqj35	86	42	serum	serum	NN
cord-002248-92pzqj35	86	43	[	[	-LRB-
cord-002248-92pzqj35	86	44	3	3	CD
cord-002248-92pzqj35	86	45	]	]	-RRB-
cord-002248-92pzqj35	86	46	.	.	.
cord-002248-92pzqj35	87	1	Anti	Anti	NNP
cord-002248-92pzqj35	87	2	-	-	NNP
cord-002248-92pzqj35	87	3	MP-12	MP-12	NNP
cord-002248-92pzqj35	87	4	mouse	mouse	NN
cord-002248-92pzqj35	87	5	serum	serum	NN
cord-002248-92pzqj35	87	6	was	be	VBD
cord-002248-92pzqj35	87	7	provided	provide	VBN
cord-002248-92pzqj35	87	8	by	by	IN
cord-002248-92pzqj35	87	9	Dr.	Dr.	NNP
cord-002248-92pzqj35	87	10	Robert	Robert	NNP
cord-002248-92pzqj35	87	11	B.	B.	NNP
cord-002248-92pzqj35	87	12	Tesh	Tesh	NNP
cord-002248-92pzqj35	87	13	at	at	IN
cord-002248-92pzqj35	87	14	The	the	DT
cord-002248-92pzqj35	87	15	University	University	NNP
cord-002248-92pzqj35	87	16	of	of	IN
cord-002248-92pzqj35	87	17	Texas	Texas	NNP
cord-002248-92pzqj35	87	18	Medical	Medical	NNP
cord-002248-92pzqj35	87	19	Branch	Branch	NNP
cord-002248-92pzqj35	87	20	.	.	.
cord-002248-92pzqj35	88	1	The	the	DT
cord-002248-92pzqj35	88	2	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	88	3	antibody	antibody	NN
cord-002248-92pzqj35	88	4	H2	h2	NN
cord-002248-92pzqj35	88	5	K	K	NNP
cord-002248-92pzqj35	88	6	k	k	NN
cord-002248-92pzqj35	88	7	D	d	NN
cord-002248-92pzqj35	88	8	k	k	NN
cord-002248-92pzqj35	88	9	(	(	-LRB-
cord-002248-92pzqj35	88	10	H2	H2	NNP
cord-002248-92pzqj35	88	11	K	K	NNP
cord-002248-92pzqj35	88	12	)	)	-RRB-
cord-002248-92pzqj35	88	13	,	,	,
cord-002248-92pzqj35	88	14	which	which	WDT
cord-002248-92pzqj35	88	15	is	be	VBZ
cord-002248-92pzqj35	88	16	against	against	IN
cord-002248-92pzqj35	88	17	major	major	JJ
cord-002248-92pzqj35	88	18	histocompatibility	histocompatibility	NN
cord-002248-92pzqj35	88	19	complex	complex	JJ
cord-002248-92pzqj35	88	20	class	class	NN
cord-002248-92pzqj35	88	21	I	-PRON-	PRP
cord-002248-92pzqj35	88	22	antigen	antigen	NN
cord-002248-92pzqj35	88	23	,	,	,
cord-002248-92pzqj35	88	24	was	be	VBD
cord-002248-92pzqj35	88	25	obtained	obtain	VBN
cord-002248-92pzqj35	88	26	from	from	IN
cord-002248-92pzqj35	88	27	Dr.	Dr.	NNP
cord-002248-92pzqj35	88	28	Paul	Paul	NNP
cord-002248-92pzqj35	88	29	Gottlieb	Gottlieb	NNP
cord-002248-92pzqj35	88	30	at	at	IN
cord-002248-92pzqj35	88	31	The	the	DT
cord-002248-92pzqj35	88	32	University	University	NNP
cord-002248-92pzqj35	88	33	of	of	IN
cord-002248-92pzqj35	88	34	Texas	Texas	NNP
cord-002248-92pzqj35	88	35	at	at	IN
cord-002248-92pzqj35	88	36	Austin	Austin	NNP
cord-002248-92pzqj35	88	37	.	.	.
cord-002248-92pzqj35	89	1	Cells	cell	NNS
cord-002248-92pzqj35	89	2	were	be	VBD
cord-002248-92pzqj35	89	3	washed	wash	VBN
cord-002248-92pzqj35	89	4	with	with	IN
cord-002248-92pzqj35	89	5	phosphate	phosphate	NN
cord-002248-92pzqj35	89	6	-	-	HYPH
cord-002248-92pzqj35	89	7	buffered	buffer	VBN
cord-002248-92pzqj35	89	8	saline	saline	NN
cord-002248-92pzqj35	89	9	(	(	-LRB-
cord-002248-92pzqj35	89	10	PBS	PBS	NNP
cord-002248-92pzqj35	89	11	)	)	-RRB-
cord-002248-92pzqj35	89	12	and	and	CC
cord-002248-92pzqj35	89	13	suspended	suspend	VBN
cord-002248-92pzqj35	89	14	in	in	IN
cord-002248-92pzqj35	89	15	SDS	SDS	NNP
cord-002248-92pzqj35	89	16	polyacrylamide	polyacrylamide	NN
cord-002248-92pzqj35	89	17	gel	gel	NN
cord-002248-92pzqj35	89	18	electrophoresis	electrophoresis	NN
cord-002248-92pzqj35	89	19	(	(	-LRB-
cord-002248-92pzqj35	89	20	SDS	SDS	NNP
cord-002248-92pzqj35	89	21	-	-	HYPH
cord-002248-92pzqj35	89	22	PAGE	PAGE	NNP
cord-002248-92pzqj35	89	23	)	)	-RRB-
cord-002248-92pzqj35	89	24	sample	sample	NN
cord-002248-92pzqj35	89	25	buffer	buffer	NN
cord-002248-92pzqj35	89	26	.	.	.
cord-002248-92pzqj35	90	1	Samples	sample	NNS
cord-002248-92pzqj35	90	2	were	be	VBD
cord-002248-92pzqj35	90	3	boiled	boil	VBN
cord-002248-92pzqj35	90	4	for	for	IN
cord-002248-92pzqj35	90	5	3	3	CD
cord-002248-92pzqj35	90	6	-	-	SYM
cord-002248-92pzqj35	90	7	5	5	CD
cord-002248-92pzqj35	90	8	min	min	NN
cord-002248-92pzqj35	90	9	and	and	CC
cord-002248-92pzqj35	90	10	subjected	subject	VBN
cord-002248-92pzqj35	90	11	to	to	IN
cord-002248-92pzqj35	90	12	SDS	SDS	NNP
cord-002248-92pzqj35	90	13	-	-	HYPH
cord-002248-92pzqj35	90	14	PAGE	PAGE	NNP
cord-002248-92pzqj35	90	15	.	.	.
cord-002248-92pzqj35	91	1	Proteins	protein	NNS
cord-002248-92pzqj35	91	2	were	be	VBD
cord-002248-92pzqj35	91	3	electroblotted	electroblotte	VBN
cord-002248-92pzqj35	91	4	onto	onto	IN
cord-002248-92pzqj35	91	5	polyvinylidene	polyvinylidene	NN
cord-002248-92pzqj35	91	6	difluoride	difluoride	NN
cord-002248-92pzqj35	91	7	membranes	membrane	NNS
cord-002248-92pzqj35	91	8	(	(	-LRB-
cord-002248-92pzqj35	91	9	immune	immune	JJ
cord-002248-92pzqj35	91	10	blot	blot	NN
cord-002248-92pzqj35	91	11	:	:	:
cord-002248-92pzqj35	92	1	Bio	Bio	NNP
cord-002248-92pzqj35	92	2	Rad	Rad	NNP
cord-002248-92pzqj35	92	3	)	)	-RRB-
cord-002248-92pzqj35	92	4	.	.	.
cord-002248-92pzqj35	93	1	After	after	IN
cord-002248-92pzqj35	93	2	blocking	block	VBG
cord-002248-92pzqj35	93	3	with	with	IN
cord-002248-92pzqj35	93	4	skim	skim	NN
cord-002248-92pzqj35	93	5	milk	milk	NN
cord-002248-92pzqj35	93	6	,	,	,
cord-002248-92pzqj35	93	7	the	the	DT
cord-002248-92pzqj35	93	8	membranes	membrane	NNS
cord-002248-92pzqj35	93	9	were	be	VBD
cord-002248-92pzqj35	93	10	incubated	incubate	VBN
cord-002248-92pzqj35	93	11	with	with	IN
cord-002248-92pzqj35	93	12	the	the	DT
cord-002248-92pzqj35	93	13	primary	primary	JJ
cord-002248-92pzqj35	93	14	antibody	antibody	NN
cord-002248-92pzqj35	93	15	for	for	IN
cord-002248-92pzqj35	93	16	1	1	CD
cord-002248-92pzqj35	93	17	h	h	NN
cord-002248-92pzqj35	93	18	at	at	IN
cord-002248-92pzqj35	93	19	room	room	NN
cord-002248-92pzqj35	93	20	temperature	temperature	NN
cord-002248-92pzqj35	93	21	and	and	CC
cord-002248-92pzqj35	93	22	with	with	IN
cord-002248-92pzqj35	93	23	the	the	DT
cord-002248-92pzqj35	93	24	secondary	secondary	JJ
cord-002248-92pzqj35	93	25	antibody	antibody	NN
cord-002248-92pzqj35	93	26	for	for	IN
cord-002248-92pzqj35	93	27	1	1	CD
cord-002248-92pzqj35	93	28	h	h	NN
cord-002248-92pzqj35	93	29	at	at	IN
cord-002248-92pzqj35	93	30	room	room	NN
cord-002248-92pzqj35	93	31	temperature	temperature	NN
cord-002248-92pzqj35	93	32	.	.	.
cord-002248-92pzqj35	94	1	The	the	DT
cord-002248-92pzqj35	94	2	proteins	protein	NNS
cord-002248-92pzqj35	94	3	on	on	IN
cord-002248-92pzqj35	94	4	the	the	DT
cord-002248-92pzqj35	94	5	membrane	membrane	NN
cord-002248-92pzqj35	94	6	were	be	VBD
cord-002248-92pzqj35	94	7	detected	detect	VBN
cord-002248-92pzqj35	94	8	by	by	IN
cord-002248-92pzqj35	94	9	using	use	VBG
cord-002248-92pzqj35	94	10	an	an	DT
cord-002248-92pzqj35	94	11	ECL	ECL	NNP
cord-002248-92pzqj35	94	12	Western	Western	NNP
cord-002248-92pzqj35	94	13	Blotting	Blotting	NNP
cord-002248-92pzqj35	94	14	Detection	Detection	NNP
cord-002248-92pzqj35	94	15	Reagent	Reagent	NNP
cord-002248-92pzqj35	94	16	(	(	-LRB-
cord-002248-92pzqj35	94	17	GE	GE	NNP
cord-002248-92pzqj35	94	18	Healthcare	Healthcare	NNP
cord-002248-92pzqj35	94	19	Life	Life	NNP
cord-002248-92pzqj35	94	20	Sciences	Sciences	NNPS
cord-002248-92pzqj35	94	21	)	)	-RRB-
cord-002248-92pzqj35	94	22	or	or	CC
cord-002248-92pzqj35	94	23	ECL	ECL	NNP
cord-002248-92pzqj35	94	24	plus	plus	CC
cord-002248-92pzqj35	94	25	Western	western	JJ
cord-002248-92pzqj35	94	26	Blotting	Blotting	NNP
cord-002248-92pzqj35	94	27	Substrate	Substrate	NNP
cord-002248-92pzqj35	94	28	(	(	-LRB-
cord-002248-92pzqj35	94	29	Pierce	Pierce	NNP
cord-002248-92pzqj35	94	30	)	)	-RRB-
cord-002248-92pzqj35	94	31	.	.	.
cord-002248-92pzqj35	95	1	Vero	Vero	NNP
cord-002248-92pzqj35	95	2	E6	E6	NNP
cord-002248-92pzqj35	95	3	cells	cell	NNS
cord-002248-92pzqj35	95	4	were	be	VBD
cord-002248-92pzqj35	95	5	infected	infect	VBN
cord-002248-92pzqj35	95	6	with	with	IN
cord-002248-92pzqj35	95	7	either	either	DT
cord-002248-92pzqj35	95	8	MP-12	MP-12	NNP
cord-002248-92pzqj35	95	9	or	or	CC
cord-002248-92pzqj35	95	10	its	-PRON-	PRP$
cord-002248-92pzqj35	95	11	mutants	mutant	NNS
cord-002248-92pzqj35	95	12	at	at	IN
cord-002248-92pzqj35	95	13	a	a	DT
cord-002248-92pzqj35	95	14	multiplicity	multiplicity	NN
cord-002248-92pzqj35	95	15	of	of	IN
cord-002248-92pzqj35	95	16	infection	infection	NN
cord-002248-92pzqj35	95	17	(	(	-LRB-
cord-002248-92pzqj35	95	18	m.o	m.o	NNP
cord-002248-92pzqj35	95	19	.	.	NNP
cord-002248-92pzqj35	95	20	i.	i.	NN
cord-002248-92pzqj35	95	21	)	)	-RRB-
cord-002248-92pzqj35	95	22	of	of	IN
cord-002248-92pzqj35	95	23	3	3	CD
cord-002248-92pzqj35	95	24	.	.	.
cord-002248-92pzqj35	96	1	At	at	IN
cord-002248-92pzqj35	96	2	16	16	CD
cord-002248-92pzqj35	96	3	h	h	NN
cord-002248-92pzqj35	96	4	post	post	NN
cord-002248-92pzqj35	96	5	infection	infection	NN
cord-002248-92pzqj35	96	6	(	(	-LRB-
cord-002248-92pzqj35	96	7	p.i	p.i	NNP
cord-002248-92pzqj35	96	8	.	.	NNP
cord-002248-92pzqj35	96	9	)	)	-RRB-
cord-002248-92pzqj35	96	10	,	,	,
cord-002248-92pzqj35	96	11	the	the	DT
cord-002248-92pzqj35	96	12	culture	culture	NN
cord-002248-92pzqj35	96	13	media	medium	NNS
cord-002248-92pzqj35	96	14	was	be	VBD
cord-002248-92pzqj35	96	15	replaced	replace	VBN
cord-002248-92pzqj35	96	16	with	with	IN
cord-002248-92pzqj35	96	17	methionine	methionine	NNP
cord-002248-92pzqj35	96	18	/	/	SYM
cord-002248-92pzqj35	96	19	cysteinefree	cysteinefree	NN
cord-002248-92pzqj35	96	20	medium	medium	NN
cord-002248-92pzqj35	96	21	.	.	.
cord-002248-92pzqj35	97	1	After	after	IN
cord-002248-92pzqj35	97	2	starvation	starvation	NN
cord-002248-92pzqj35	97	3	for	for	IN
cord-002248-92pzqj35	97	4	30	30	CD
cord-002248-92pzqj35	97	5	min	min	NN
cord-002248-92pzqj35	97	6	,	,	,
cord-002248-92pzqj35	97	7	the	the	DT
cord-002248-92pzqj35	97	8	infected	infected	JJ
cord-002248-92pzqj35	97	9	cells	cell	NNS
cord-002248-92pzqj35	97	10	were	be	VBD
cord-002248-92pzqj35	97	11	labeled	label	VBN
cord-002248-92pzqj35	97	12	with	with	IN
cord-002248-92pzqj35	97	13	100	100	CD
cord-002248-92pzqj35	97	14	μCi	μCi	NNS
cord-002248-92pzqj35	97	15	/	/	SYM
cord-002248-92pzqj35	97	16	ml	ml	NNS
cord-002248-92pzqj35	97	17	of	of	IN
cord-002248-92pzqj35	97	18	35	35	CD
cord-002248-92pzqj35	97	19	S	s	NN
cord-002248-92pzqj35	97	20	-	-	HYPH
cord-002248-92pzqj35	97	21	methionine	methionine	NN
cord-002248-92pzqj35	97	22	/	/	SYM
cord-002248-92pzqj35	97	23	cysteine	cysteine	NN
cord-002248-92pzqj35	97	24	(	(	-LRB-
cord-002248-92pzqj35	97	25	1,000	1,000	CD
cord-002248-92pzqj35	97	26	Ci	ci	NN
cord-002248-92pzqj35	97	27	/	/	SYM
cord-002248-92pzqj35	97	28	mmol	mmol	NN
cord-002248-92pzqj35	97	29	;	;	:
cord-002248-92pzqj35	97	30	MP	MP	NNP
cord-002248-92pzqj35	97	31	Biomedicals	Biomedicals	NNP
cord-002248-92pzqj35	97	32	)	)	-RRB-
cord-002248-92pzqj35	97	33	for	for	IN
cord-002248-92pzqj35	97	34	1	1	CD
cord-002248-92pzqj35	97	35	h.	h.	NN
cord-002248-92pzqj35	98	1	The	the	DT
cord-002248-92pzqj35	98	2	radiolabeled	radiolabeled	JJ
cord-002248-92pzqj35	98	3	cells	cell	NNS
cord-002248-92pzqj35	98	4	were	be	VBD
cord-002248-92pzqj35	98	5	suspended	suspend	VBN
cord-002248-92pzqj35	98	6	in	in	IN
cord-002248-92pzqj35	98	7	2x	2x	CD
cord-002248-92pzqj35	98	8	SDS	SDS	NNP
cord-002248-92pzqj35	98	9	-	-	HYPH
cord-002248-92pzqj35	98	10	PAGE	page	NN
cord-002248-92pzqj35	98	11	sample	sample	NN
cord-002248-92pzqj35	98	12	buffer	buffer	NN
cord-002248-92pzqj35	98	13	,	,	,
cord-002248-92pzqj35	98	14	resolved	resolve	VBN
cord-002248-92pzqj35	98	15	by	by	IN
cord-002248-92pzqj35	98	16	SDS	SDS	NNP
cord-002248-92pzqj35	98	17	-	-	HYPH
cord-002248-92pzqj35	98	18	PAGE	PAGE	NNP
cord-002248-92pzqj35	98	19	and	and	CC
cord-002248-92pzqj35	98	20	visualized	visualize	VBN
cord-002248-92pzqj35	98	21	by	by	IN
cord-002248-92pzqj35	98	22	Coomassie	Coomassie	NNP
cord-002248-92pzqj35	98	23	Blue	Blue	NNP
cord-002248-92pzqj35	98	24	staining	staining	NN
cord-002248-92pzqj35	98	25	or	or	CC
cord-002248-92pzqj35	98	26	autoradiography	autoradiography	NN
cord-002248-92pzqj35	98	27	.	.	.
cord-002248-92pzqj35	99	1	The	the	DT
cord-002248-92pzqj35	99	2	Click	Click	NNP
cord-002248-92pzqj35	99	3	-	-	HYPH
cord-002248-92pzqj35	99	4	iT	it	PRP
cord-002248-92pzqj35	99	5	RNA	RNA	NNP
cord-002248-92pzqj35	99	6	Alexa	Alexa	NNP
cord-002248-92pzqj35	99	7	Fluor	Fluor	NNP
cord-002248-92pzqj35	99	8	488	488	CD
cord-002248-92pzqj35	99	9	Imaging	Imaging	NNP
cord-002248-92pzqj35	99	10	Kit	Kit	NNP
cord-002248-92pzqj35	99	11	was	be	VBD
cord-002248-92pzqj35	99	12	purchased	purchase	VBN
cord-002248-92pzqj35	99	13	from	from	IN
cord-002248-92pzqj35	99	14	Thermo	Thermo	NNP
cord-002248-92pzqj35	99	15	Fisher	Fisher	NNP
cord-002248-92pzqj35	99	16	Scientific	Scientific	NNP
cord-002248-92pzqj35	99	17	.	.	.
cord-002248-92pzqj35	100	1	Vero	Vero	NNP
cord-002248-92pzqj35	100	2	E6	E6	NNP
cord-002248-92pzqj35	100	3	cells	cell	NNS
cord-002248-92pzqj35	100	4	were	be	VBD
cord-002248-92pzqj35	100	5	infected	infect	VBN
cord-002248-92pzqj35	100	6	with	with	IN
cord-002248-92pzqj35	100	7	recombinant	recombinant	JJ
cord-002248-92pzqj35	100	8	viruses	virus	NNS
cord-002248-92pzqj35	100	9	at	at	IN
cord-002248-92pzqj35	100	10	an	an	DT
cord-002248-92pzqj35	100	11	m.o.i	m.o.i	NN
cord-002248-92pzqj35	100	12	.	.	NN
cord-002248-92pzqj35	100	13	of	of	IN
cord-002248-92pzqj35	100	14	3	3	CD
cord-002248-92pzqj35	100	15	and	and	CC
cord-002248-92pzqj35	100	16	incubated	incubate	VBN
cord-002248-92pzqj35	100	17	with	with	IN
cord-002248-92pzqj35	100	18	1	1	CD
cord-002248-92pzqj35	100	19	mM	mm	CD
cord-002248-92pzqj35	100	20	of	of	IN
cord-002248-92pzqj35	100	21	5-ethynyl	5-ethynyl	CD
cord-002248-92pzqj35	100	22	uridine	uridine	NN
cord-002248-92pzqj35	100	23	(	(	-LRB-
cord-002248-92pzqj35	100	24	5EU	5eu	CD
cord-002248-92pzqj35	100	25	)	)	-RRB-
cord-002248-92pzqj35	100	26	for	for	IN
cord-002248-92pzqj35	100	27	1	1	CD
cord-002248-92pzqj35	100	28	h	h	NN
cord-002248-92pzqj35	100	29	at	at	IN
cord-002248-92pzqj35	100	30	16	16	CD
cord-002248-92pzqj35	100	31	h	h	NN
cord-002248-92pzqj35	100	32	p.i	p.i	NNP
cord-002248-92pzqj35	100	33	.	.	NNP
cord-002248-92pzqj35	100	34	Cellular	Cellular	NNP
cord-002248-92pzqj35	100	35	RNA	RNA	NNP
cord-002248-92pzqj35	100	36	was	be	VBD
cord-002248-92pzqj35	100	37	stained	stain	VBN
cord-002248-92pzqj35	100	38	with	with	IN
cord-002248-92pzqj35	100	39	Alexa	Alexa	NNP
cord-002248-92pzqj35	100	40	fluor	fluor	NNP
cord-002248-92pzqj35	100	41	,	,	,
cord-002248-92pzqj35	100	42	488-coupled	488-coupled	CD
cord-002248-92pzqj35	100	43	azide	azide	NN
cord-002248-92pzqj35	100	44	for	for	IN
cord-002248-92pzqj35	100	45	30	30	CD
cord-002248-92pzqj35	100	46	min	min	NN
cord-002248-92pzqj35	100	47	by	by	IN
cord-002248-92pzqj35	100	48	following	follow	VBG
cord-002248-92pzqj35	100	49	the	the	DT
cord-002248-92pzqj35	100	50	manufacturer	manufacturer	NN
cord-002248-92pzqj35	100	51	's	's	POS
cord-002248-92pzqj35	100	52	protocol	protocol	NN
cord-002248-92pzqj35	100	53	.	.	.
cord-002248-92pzqj35	101	1	For	for	IN
cord-002248-92pzqj35	101	2	a	a	DT
cord-002248-92pzqj35	101	3	negative	negative	JJ
cord-002248-92pzqj35	101	4	control	control	NN
cord-002248-92pzqj35	101	5	,	,	,
cord-002248-92pzqj35	101	6	mock	mock	JJ
cord-002248-92pzqj35	101	7	-	-	HYPH
cord-002248-92pzqj35	101	8	infected	infect	VBN
cord-002248-92pzqj35	101	9	cells	cell	NNS
cord-002248-92pzqj35	101	10	were	be	VBD
cord-002248-92pzqj35	101	11	treated	treat	VBN
cord-002248-92pzqj35	101	12	with	with	IN
cord-002248-92pzqj35	101	13	5	5	CD
cord-002248-92pzqj35	101	14	μg	μg	NNP
cord-002248-92pzqj35	101	15	/	/	SYM
cord-002248-92pzqj35	101	16	ml	ml	NNS
cord-002248-92pzqj35	101	17	of	of	IN
cord-002248-92pzqj35	101	18	actinomycin	actinomycin	NNS
cord-002248-92pzqj35	101	19	D	D	NNP
cord-002248-92pzqj35	101	20	(	(	-LRB-
cord-002248-92pzqj35	101	21	ActD	ActD	NNP
cord-002248-92pzqj35	101	22	)	)	-RRB-
cord-002248-92pzqj35	101	23	for	for	IN
cord-002248-92pzqj35	101	24	30	30	CD
cord-002248-92pzqj35	101	25	min	min	NN
cord-002248-92pzqj35	101	26	prior	prior	RB
cord-002248-92pzqj35	101	27	to	to	IN
cord-002248-92pzqj35	101	28	5EU	5eu	CD
cord-002248-92pzqj35	101	29	treatment	treatment	NN
cord-002248-92pzqj35	101	30	and	and	CC
cord-002248-92pzqj35	101	31	for	for	IN
cord-002248-92pzqj35	101	32	1	1	CD
cord-002248-92pzqj35	101	33	h	h	NN
cord-002248-92pzqj35	101	34	during	during	IN
cord-002248-92pzqj35	101	35	5EU	5eu	CD
cord-002248-92pzqj35	101	36	treatment	treatment	NN
cord-002248-92pzqj35	101	37	.	.	.
cord-002248-92pzqj35	102	1	After	after	IN
cord-002248-92pzqj35	102	2	the	the	DT
cord-002248-92pzqj35	102	3	click	click	NN
cord-002248-92pzqj35	102	4	reaction	reaction	NN
cord-002248-92pzqj35	102	5	,	,	,
cord-002248-92pzqj35	102	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	102	7	N	N	NNP
cord-002248-92pzqj35	102	8	protein	protein	NN
cord-002248-92pzqj35	102	9	was	be	VBD
cord-002248-92pzqj35	102	10	stained	stain	VBN
cord-002248-92pzqj35	102	11	with	with	IN
cord-002248-92pzqj35	102	12	anti	anti	JJ
cord-002248-92pzqj35	102	13	-	-	JJ
cord-002248-92pzqj35	102	14	GST	gst	JJ
cord-002248-92pzqj35	102	15	-	-	HYPH
cord-002248-92pzqj35	102	16	N	n	CD
cord-002248-92pzqj35	102	17	rabbit	rabbit	NN
cord-002248-92pzqj35	102	18	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	102	19	antibody	antibody	NN
cord-002248-92pzqj35	102	20	followed	follow	VBN
cord-002248-92pzqj35	102	21	by	by	IN
cord-002248-92pzqj35	102	22	Alexa	Alexa	NNP
cord-002248-92pzqj35	102	23	fluor	fluor	NNP
cord-002248-92pzqj35	102	24	594	594	CD
cord-002248-92pzqj35	102	25	conjugated	conjugate	VBD
cord-002248-92pzqj35	102	26	anti	anti	JJ
cord-002248-92pzqj35	102	27	-	-	JJ
cord-002248-92pzqj35	102	28	rabbit	rabbit	JJ
cord-002248-92pzqj35	102	29	antibody	antibody	NN
cord-002248-92pzqj35	102	30	.	.	.
cord-002248-92pzqj35	103	1	Images	image	NNS
cord-002248-92pzqj35	103	2	were	be	VBD
cord-002248-92pzqj35	103	3	captured	capture	VBN
cord-002248-92pzqj35	103	4	on	on	IN
cord-002248-92pzqj35	103	5	a	a	DT
cord-002248-92pzqj35	103	6	Zeiss	Zeiss	NNP
cord-002248-92pzqj35	103	7	Axiophot	Axiophot	NNP
cord-002248-92pzqj35	103	8	2	2	CD
cord-002248-92pzqj35	103	9	fluorescence	fluorescence	NN
cord-002248-92pzqj35	103	10	microscope	microscope	NN
cord-002248-92pzqj35	103	11	with	with	IN
cord-002248-92pzqj35	103	12	a	a	DT
cord-002248-92pzqj35	103	13	40x	40x	CD
cord-002248-92pzqj35	103	14	magnification	magnification	NN
cord-002248-92pzqj35	103	15	lens	lens	NN
cord-002248-92pzqj35	103	16	and	and	CC
cord-002248-92pzqj35	103	17	processed	process	VBN
cord-002248-92pzqj35	103	18	with	with	IN
cord-002248-92pzqj35	103	19	the	the	DT
cord-002248-92pzqj35	103	20	ImageJ	ImageJ	NNP
cord-002248-92pzqj35	103	21	software	software	NN
cord-002248-92pzqj35	103	22	[	[	-LRB-
cord-002248-92pzqj35	103	23	27	27	CD
cord-002248-92pzqj35	103	24	]	]	-RRB-
cord-002248-92pzqj35	103	25	.	.	.
cord-002248-92pzqj35	104	1	For	for	IN
cord-002248-92pzqj35	104	2	flow	flow	NN
cord-002248-92pzqj35	104	3	cytometry	cytometry	NN
cord-002248-92pzqj35	104	4	analysis	analysis	NN
cord-002248-92pzqj35	104	5	,	,	,
cord-002248-92pzqj35	104	6	the	the	DT
cord-002248-92pzqj35	104	7	infected	infected	JJ
cord-002248-92pzqj35	104	8	cells	cell	NNS
cord-002248-92pzqj35	104	9	were	be	VBD
cord-002248-92pzqj35	104	10	detached	detach	VBN
cord-002248-92pzqj35	104	11	from	from	IN
cord-002248-92pzqj35	104	12	the	the	DT
cord-002248-92pzqj35	104	13	dish	dish	NN
cord-002248-92pzqj35	104	14	by	by	IN
cord-002248-92pzqj35	104	15	Accumax	Accumax	NNP
cord-002248-92pzqj35	104	16	(	(	-LRB-
cord-002248-92pzqj35	104	17	Innovative	Innovative	NNP
cord-002248-92pzqj35	104	18	Cell	Cell	NNP
cord-002248-92pzqj35	104	19	Technologies	Technologies	NNPS
cord-002248-92pzqj35	104	20	)	)	-RRB-
cord-002248-92pzqj35	104	21	after	after	IN
cord-002248-92pzqj35	104	22	the	the	DT
cord-002248-92pzqj35	104	23	5EU	5eu	CD
cord-002248-92pzqj35	104	24	treatment	treatment	NN
cord-002248-92pzqj35	104	25	and	and	CC
cord-002248-92pzqj35	104	26	suspended	suspend	VBN
cord-002248-92pzqj35	104	27	in	in	IN
cord-002248-92pzqj35	104	28	culture	culture	NN
cord-002248-92pzqj35	104	29	media	medium	NNS
cord-002248-92pzqj35	104	30	.	.	.
cord-002248-92pzqj35	105	1	After	after	IN
cord-002248-92pzqj35	105	2	washing	wash	VBG
cord-002248-92pzqj35	105	3	with	with	IN
cord-002248-92pzqj35	105	4	PBS	PBS	NNP
cord-002248-92pzqj35	105	5	containing	contain	VBG
cord-002248-92pzqj35	105	6	1	1	CD
cord-002248-92pzqj35	105	7	%	%	NN
cord-002248-92pzqj35	105	8	bovine	bovine	JJ
cord-002248-92pzqj35	105	9	serum	serum	NN
cord-002248-92pzqj35	105	10	albumin	albumin	NN
cord-002248-92pzqj35	105	11	(	(	-LRB-
cord-002248-92pzqj35	105	12	BSA	BSA	NNP
cord-002248-92pzqj35	105	13	)	)	-RRB-
cord-002248-92pzqj35	105	14	,	,	,
cord-002248-92pzqj35	105	15	cells	cell	NNS
cord-002248-92pzqj35	105	16	were	be	VBD
cord-002248-92pzqj35	105	17	fixed	fix	VBN
cord-002248-92pzqj35	105	18	with	with	IN
cord-002248-92pzqj35	105	19	2	2	CD
cord-002248-92pzqj35	105	20	%	%	NN
cord-002248-92pzqj35	105	21	formaldehyde	formaldehyde	NN
cord-002248-92pzqj35	105	22	/	/	SYM
cord-002248-92pzqj35	105	23	PBS	PBS	NNP
cord-002248-92pzqj35	105	24	for	for	IN
cord-002248-92pzqj35	105	25	30	30	CD
cord-002248-92pzqj35	105	26	min	min	NN
cord-002248-92pzqj35	105	27	at	at	IN
cord-002248-92pzqj35	105	28	room	room	NN
cord-002248-92pzqj35	105	29	temperature	temperature	NN
cord-002248-92pzqj35	105	30	and	and	CC
cord-002248-92pzqj35	105	31	blocked	block	VBN
cord-002248-92pzqj35	105	32	with	with	IN
cord-002248-92pzqj35	105	33	blocking	block	VBG
cord-002248-92pzqj35	105	34	buffer	buffer	NN
cord-002248-92pzqj35	105	35	(	(	-LRB-
cord-002248-92pzqj35	105	36	PBS	PBS	NNP
cord-002248-92pzqj35	105	37	containing	contain	VBG
cord-002248-92pzqj35	105	38	0.2	0.2	CD
cord-002248-92pzqj35	105	39	%	%	NN
cord-002248-92pzqj35	105	40	saponin	saponin	NN
cord-002248-92pzqj35	105	41	and	and	CC
cord-002248-92pzqj35	105	42	1	1	CD
cord-002248-92pzqj35	105	43	%	%	NN
cord-002248-92pzqj35	105	44	BSA	BSA	NNP
cord-002248-92pzqj35	105	45	)	)	-RRB-
cord-002248-92pzqj35	105	46	for	for	IN
cord-002248-92pzqj35	105	47	15	15	CD
cord-002248-92pzqj35	105	48	min	min	NN
cord-002248-92pzqj35	105	49	on	on	IN
cord-002248-92pzqj35	105	50	ice	ice	NN
cord-002248-92pzqj35	105	51	.	.	.
cord-002248-92pzqj35	106	1	Cellular	Cellular	NNP
cord-002248-92pzqj35	106	2	RNA	RNA	NNP
cord-002248-92pzqj35	106	3	was	be	VBD
cord-002248-92pzqj35	106	4	stained	stain	VBN
cord-002248-92pzqj35	106	5	by	by	IN
cord-002248-92pzqj35	106	6	Alexa	Alexa	NNP
cord-002248-92pzqj35	106	7	fluor	fluor	NNP
cord-002248-92pzqj35	106	8	488-coupled	488-coupled	CD
cord-002248-92pzqj35	106	9	azide	azide	NN
cord-002248-92pzqj35	106	10	for	for	IN
cord-002248-92pzqj35	106	11	30	30	CD
cord-002248-92pzqj35	106	12	min	min	NN
cord-002248-92pzqj35	106	13	in	in	IN
cord-002248-92pzqj35	106	14	the	the	DT
cord-002248-92pzqj35	106	15	presence	presence	NN
cord-002248-92pzqj35	106	16	of	of	IN
cord-002248-92pzqj35	106	17	0.5	0.5	CD
cord-002248-92pzqj35	106	18	%	%	NN
cord-002248-92pzqj35	106	19	saponin	saponin	NN
cord-002248-92pzqj35	106	20	and	and	CC
cord-002248-92pzqj35	106	21	1	1	CD
cord-002248-92pzqj35	106	22	%	%	NN
cord-002248-92pzqj35	106	23	BSA	BSA	NNP
cord-002248-92pzqj35	106	24	.	.	.
cord-002248-92pzqj35	107	1	After	after	IN
cord-002248-92pzqj35	107	2	washing	wash	VBG
cord-002248-92pzqj35	107	3	with	with	IN
cord-002248-92pzqj35	107	4	the	the	DT
cord-002248-92pzqj35	107	5	blocking	block	VBG
cord-002248-92pzqj35	107	6	buffer	buffer	NN
cord-002248-92pzqj35	107	7	,	,	,
cord-002248-92pzqj35	107	8	RVFV	RVFV	NNP
cord-002248-92pzqj35	107	9	N	N	NNP
cord-002248-92pzqj35	107	10	protein	protein	NN
cord-002248-92pzqj35	107	11	was	be	VBD
cord-002248-92pzqj35	107	12	stained	stain	VBN
cord-002248-92pzqj35	107	13	by	by	IN
cord-002248-92pzqj35	107	14	anti	anti	JJ
cord-002248-92pzqj35	107	15	-	-	JJ
cord-002248-92pzqj35	107	16	GST	gst	JJ
cord-002248-92pzqj35	107	17	-	-	HYPH
cord-002248-92pzqj35	107	18	N	n	CD
cord-002248-92pzqj35	107	19	rabbit	rabbit	NN
cord-002248-92pzqj35	107	20	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	107	21	antibody	antibody	NN
cord-002248-92pzqj35	107	22	for	for	IN
cord-002248-92pzqj35	107	23	30	30	CD
cord-002248-92pzqj35	107	24	min	min	NN
cord-002248-92pzqj35	107	25	on	on	IN
cord-002248-92pzqj35	107	26	ice	ice	NN
cord-002248-92pzqj35	107	27	followed	follow	VBN
cord-002248-92pzqj35	107	28	by	by	IN
cord-002248-92pzqj35	107	29	Alexa	Alexa	NNP
cord-002248-92pzqj35	107	30	fluor	fluor	NNP
cord-002248-92pzqj35	107	31	594	594	CD
cord-002248-92pzqj35	107	32	conjugated	conjugate	VBD
cord-002248-92pzqj35	107	33	anti	anti	JJ
cord-002248-92pzqj35	107	34	-	-	JJ
cord-002248-92pzqj35	107	35	rabbit	rabbit	JJ
cord-002248-92pzqj35	107	36	antibody	antibody	NN
cord-002248-92pzqj35	107	37	.	.	.
cord-002248-92pzqj35	108	1	The	the	DT
cord-002248-92pzqj35	108	2	cells	cell	NNS
cord-002248-92pzqj35	108	3	were	be	VBD
cord-002248-92pzqj35	108	4	washed	wash	VBN
cord-002248-92pzqj35	108	5	with	with	IN
cord-002248-92pzqj35	108	6	PBS	PBS	NNP
cord-002248-92pzqj35	108	7	containing	contain	VBG
cord-002248-92pzqj35	108	8	1	1	CD
cord-002248-92pzqj35	108	9	%	%	NN
cord-002248-92pzqj35	108	10	BSA	BSA	NNP
cord-002248-92pzqj35	108	11	,	,	,
cord-002248-92pzqj35	108	12	passed	pass	VBD
cord-002248-92pzqj35	108	13	through	through	IN
cord-002248-92pzqj35	108	14	a	a	DT
cord-002248-92pzqj35	108	15	cell	cell	NN
cord-002248-92pzqj35	108	16	strainer	strainer	NN
cord-002248-92pzqj35	108	17	(	(	-LRB-
cord-002248-92pzqj35	108	18	BD	BD	NNP
cord-002248-92pzqj35	108	19	Falcon	Falcon	NNP
cord-002248-92pzqj35	108	20	)	)	-RRB-
cord-002248-92pzqj35	108	21	,	,	,
cord-002248-92pzqj35	108	22	and	and	CC
cord-002248-92pzqj35	108	23	analyzed	analyze	VBD
cord-002248-92pzqj35	108	24	on	on	IN
cord-002248-92pzqj35	108	25	an	an	DT
cord-002248-92pzqj35	108	26	LSRII	LSRII	NNP
cord-002248-92pzqj35	108	27	Fortessa	Fortessa	NNP
cord-002248-92pzqj35	108	28	(	(	-LRB-
cord-002248-92pzqj35	108	29	BD	BD	NNP
cord-002248-92pzqj35	108	30	Biosciences	Biosciences	NNP
cord-002248-92pzqj35	108	31	)	)	-RRB-
cord-002248-92pzqj35	108	32	.	.	.
cord-002248-92pzqj35	109	1	Single	single	JJ
cord-002248-92pzqj35	109	2	cells	cell	NNS
cord-002248-92pzqj35	109	3	were	be	VBD
cord-002248-92pzqj35	109	4	gated	gate	VBN
cord-002248-92pzqj35	109	5	based	base	VBN
cord-002248-92pzqj35	109	6	on	on	IN
cord-002248-92pzqj35	109	7	their	-PRON-	PRP$
cord-002248-92pzqj35	109	8	forward	forward	JJ
cord-002248-92pzqj35	109	9	scatter	scatter	NN
cord-002248-92pzqj35	109	10	and	and	CC
cord-002248-92pzqj35	109	11	side	side	NN
cord-002248-92pzqj35	109	12	scatter	scatter	NN
cord-002248-92pzqj35	109	13	profile	profile	NN
cord-002248-92pzqj35	109	14	.	.	.
cord-002248-92pzqj35	110	1	More	More	JJR
cord-002248-92pzqj35	110	2	than	than	IN
cord-002248-92pzqj35	110	3	30,000	30,000	CD
cord-002248-92pzqj35	110	4	count	count	NN
cord-002248-92pzqj35	110	5	of	of	IN
cord-002248-92pzqj35	110	6	the	the	DT
cord-002248-92pzqj35	110	7	gated	gated	JJ
cord-002248-92pzqj35	110	8	single	single	JJ
cord-002248-92pzqj35	110	9	cells	cell	NNS
cord-002248-92pzqj35	110	10	were	be	VBD
cord-002248-92pzqj35	110	11	analyzed	analyze	VBN
cord-002248-92pzqj35	110	12	for	for	IN
cord-002248-92pzqj35	110	13	each	each	DT
cord-002248-92pzqj35	110	14	experiment	experiment	NN
cord-002248-92pzqj35	110	15	.	.	.
cord-002248-92pzqj35	111	1	Confluent	Confluent	NNP
cord-002248-92pzqj35	111	2	Vero	Vero	NNP
cord-002248-92pzqj35	111	3	E6	E6	NNP
cord-002248-92pzqj35	111	4	cells	cell	NNS
cord-002248-92pzqj35	111	5	grown	grow	VBN
cord-002248-92pzqj35	111	6	in	in	IN
cord-002248-92pzqj35	111	7	96-well	96-well	CD
cord-002248-92pzqj35	111	8	plates	plate	NNS
cord-002248-92pzqj35	111	9	were	be	VBD
cord-002248-92pzqj35	111	10	either	either	CC
cord-002248-92pzqj35	111	11	mock	mock	VB
cord-002248-92pzqj35	111	12	infected	infect	VBN
cord-002248-92pzqj35	111	13	or	or	CC
cord-002248-92pzqj35	111	14	with	with	IN
cord-002248-92pzqj35	111	15	mutant	mutant	JJ
cord-002248-92pzqj35	111	16	virus	virus	NN
cord-002248-92pzqj35	111	17	at	at	IN
cord-002248-92pzqj35	111	18	an	an	DT
cord-002248-92pzqj35	111	19	m.o.i	m.o.i	NN
cord-002248-92pzqj35	111	20	.	.	NN
cord-002248-92pzqj35	111	21	of	of	IN
cord-002248-92pzqj35	111	22	3	3	CD
cord-002248-92pzqj35	111	23	.	.	.
cord-002248-92pzqj35	112	1	Cell	cell	NN
cord-002248-92pzqj35	112	2	viability	viability	NN
cord-002248-92pzqj35	112	3	was	be	VBD
cord-002248-92pzqj35	112	4	determined	determine	VBN
cord-002248-92pzqj35	112	5	by	by	IN
cord-002248-92pzqj35	112	6	using	use	VBG
cord-002248-92pzqj35	112	7	Viral	Viral	NNP
cord-002248-92pzqj35	112	8	ToxGlo	ToxGlo	NNP
cord-002248-92pzqj35	112	9	(	(	-LRB-
cord-002248-92pzqj35	112	10	Promega	Promega	NNP
cord-002248-92pzqj35	112	11	)	)	-RRB-
cord-002248-92pzqj35	112	12	,	,	,
cord-002248-92pzqj35	112	13	which	which	WDT
cord-002248-92pzqj35	112	14	measures	measure	VBZ
cord-002248-92pzqj35	112	15	cellular	cellular	JJ
cord-002248-92pzqj35	112	16	ATP	ATP	NNP
cord-002248-92pzqj35	112	17	.	.	.
cord-002248-92pzqj35	113	1	At	at	IN
cord-002248-92pzqj35	113	2	various	various	JJ
cord-002248-92pzqj35	113	3	times	time	NNS
cord-002248-92pzqj35	113	4	p.i	p.i	NNP
cord-002248-92pzqj35	113	5	.	.	NNP
cord-002248-92pzqj35	113	6	,	,	,
cord-002248-92pzqj35	113	7	ATP	ATP	NNP
cord-002248-92pzqj35	113	8	detection	detection	NN
cord-002248-92pzqj35	113	9	reagent	reagent	NN
cord-002248-92pzqj35	113	10	was	be	VBD
cord-002248-92pzqj35	113	11	added	add	VBN
cord-002248-92pzqj35	113	12	to	to	IN
cord-002248-92pzqj35	113	13	each	each	DT
cord-002248-92pzqj35	113	14	well	well	RB
cord-002248-92pzqj35	113	15	.	.	.
cord-002248-92pzqj35	114	1	After	after	IN
cord-002248-92pzqj35	114	2	incubation	incubation	NN
cord-002248-92pzqj35	114	3	for	for	IN
cord-002248-92pzqj35	114	4	10	10	CD
cord-002248-92pzqj35	114	5	min	min	NN
cord-002248-92pzqj35	114	6	,	,	,
cord-002248-92pzqj35	114	7	luminescence	luminescence	NN
cord-002248-92pzqj35	114	8	was	be	VBD
cord-002248-92pzqj35	114	9	measured	measure	VBN
cord-002248-92pzqj35	114	10	by	by	IN
cord-002248-92pzqj35	114	11	SpectraMax	SpectraMax	NNP
cord-002248-92pzqj35	114	12	M5e	M5e	NNP
cord-002248-92pzqj35	115	1	(	(	-LRB-
cord-002248-92pzqj35	115	2	Molecular	Molecular	NNP
cord-002248-92pzqj35	115	3	Devices	Devices	NNPS
cord-002248-92pzqj35	115	4	)	)	-RRB-
cord-002248-92pzqj35	115	5	.	.	.
cord-002248-92pzqj35	116	1	Total	total	JJ
cord-002248-92pzqj35	116	2	RNAs	rna	NNS
cord-002248-92pzqj35	116	3	were	be	VBD
cord-002248-92pzqj35	116	4	extracted	extract	VBN
cord-002248-92pzqj35	116	5	by	by	IN
cord-002248-92pzqj35	116	6	using	use	VBG
cord-002248-92pzqj35	116	7	TRIzol	TRIzol	NNP
cord-002248-92pzqj35	116	8	reagent	reagent	NN
cord-002248-92pzqj35	116	9	(	(	-LRB-
cord-002248-92pzqj35	116	10	Invitrogen	Invitrogen	NNP
cord-002248-92pzqj35	116	11	)	)	-RRB-
cord-002248-92pzqj35	116	12	and	and	CC
cord-002248-92pzqj35	116	13	subjected	subject	VBN
cord-002248-92pzqj35	116	14	to	to	IN
cord-002248-92pzqj35	116	15	Northern	northern	JJ
cord-002248-92pzqj35	116	16	blot	blot	NN
cord-002248-92pzqj35	116	17	analysis	analysis	NN
cord-002248-92pzqj35	116	18	as	as	IN
cord-002248-92pzqj35	116	19	described	describe	VBN
cord-002248-92pzqj35	116	20	previously	previously	RB
cord-002248-92pzqj35	116	21	[	[	-LRB-
cord-002248-92pzqj35	116	22	28	28	CD
cord-002248-92pzqj35	116	23	]	]	-RRB-
cord-002248-92pzqj35	116	24	.	.	.
cord-002248-92pzqj35	117	1	Strand	strand	NN
cord-002248-92pzqj35	117	2	-	-	HYPH
cord-002248-92pzqj35	117	3	specific	specific	JJ
cord-002248-92pzqj35	117	4	digoxigenin	digoxigenin	NNS
cord-002248-92pzqj35	117	5	-	-	HYPH
cord-002248-92pzqj35	117	6	labeled	label	VBN
cord-002248-92pzqj35	117	7	RNA	RNA	NNP
cord-002248-92pzqj35	117	8	probes	probe	NNS
cord-002248-92pzqj35	117	9	and	and	CC
cord-002248-92pzqj35	117	10	a	a	DT
cord-002248-92pzqj35	117	11	digoxigenin	digoxigenin	NN
cord-002248-92pzqj35	117	12	(	(	-LRB-
cord-002248-92pzqj35	117	13	DIG	dig	VB
cord-002248-92pzqj35	117	14	)	)	-RRB-
cord-002248-92pzqj35	117	15	system	system	NN
cord-002248-92pzqj35	117	16	(	(	-LRB-
cord-002248-92pzqj35	117	17	Roche	Roche	NNP
cord-002248-92pzqj35	117	18	)	)	-RRB-
cord-002248-92pzqj35	117	19	were	be	VBD
cord-002248-92pzqj35	117	20	used	use	VBN
cord-002248-92pzqj35	117	21	to	to	TO
cord-002248-92pzqj35	117	22	detect	detect	VB
cord-002248-92pzqj35	117	23	RNA	RNA	NNP
cord-002248-92pzqj35	117	24	.	.	.
cord-002248-92pzqj35	118	1	The	the	DT
cord-002248-92pzqj35	118	2	564-nucleotide	564-nucleotide	CD
cord-002248-92pzqj35	118	3	-	-	HYPH
cord-002248-92pzqj35	118	4	long	long	JJ
cord-002248-92pzqj35	118	5	,	,	,
cord-002248-92pzqj35	118	6	293	293	CD
cord-002248-92pzqj35	118	7	cell	cell	NN
cord-002248-92pzqj35	118	8	-	-	HYPH
cord-002248-92pzqj35	118	9	derived	derive	VBN
cord-002248-92pzqj35	118	10	,	,	,
cord-002248-92pzqj35	118	11	and	and	CC
cord-002248-92pzqj35	118	12	DIG	dig	VB
cord-002248-92pzqj35	118	13	-	-	HYPH
cord-002248-92pzqj35	118	14	labeled	label	VBN
cord-002248-92pzqj35	118	15	IFN	IFN	NNP
cord-002248-92pzqj35	118	16	-	-	HYPH
cord-002248-92pzqj35	118	17	β	β	NNP
cord-002248-92pzqj35	118	18	riboprobe	riboprobe	NNP
cord-002248-92pzqj35	118	19	[	[	-LRB-
cord-002248-92pzqj35	118	20	29	29	CD
cord-002248-92pzqj35	118	21	]	]	-RRB-
cord-002248-92pzqj35	118	22	was	be	VBD
cord-002248-92pzqj35	118	23	used	use	VBN
cord-002248-92pzqj35	118	24	for	for	IN
cord-002248-92pzqj35	118	25	IFN	IFN	NNP
cord-002248-92pzqj35	118	26	-	-	HYPH
cord-002248-92pzqj35	118	27	β	β	NNP
cord-002248-92pzqj35	118	28	mRNA	mrna	NN
cord-002248-92pzqj35	118	29	detection	detection	NN
cord-002248-92pzqj35	118	30	.	.	.
cord-002248-92pzqj35	119	1	Cells	cell	NNS
cord-002248-92pzqj35	119	2	cultured	cultured	JJ
cord-002248-92pzqj35	119	3	on	on	IN
cord-002248-92pzqj35	119	4	chamber	chamber	NN
cord-002248-92pzqj35	119	5	slides	slide	NNS
cord-002248-92pzqj35	119	6	were	be	VBD
cord-002248-92pzqj35	119	7	fixed	fix	VBN
cord-002248-92pzqj35	119	8	in	in	IN
cord-002248-92pzqj35	119	9	4	4	CD
cord-002248-92pzqj35	119	10	%	%	NN
cord-002248-92pzqj35	119	11	paraformaldehyde	paraformaldehyde	NNP
cord-002248-92pzqj35	119	12	for	for	IN
cord-002248-92pzqj35	119	13	15	15	CD
cord-002248-92pzqj35	119	14	min	min	NN
cord-002248-92pzqj35	119	15	.	.	.
cord-002248-92pzqj35	120	1	The	the	DT
cord-002248-92pzqj35	120	2	fixed	fix	VBN
cord-002248-92pzqj35	120	3	cells	cell	NNS
cord-002248-92pzqj35	120	4	were	be	VBD
cord-002248-92pzqj35	120	5	permeabilized	permeabilize	VBN
cord-002248-92pzqj35	120	6	with	with	IN
cord-002248-92pzqj35	120	7	0.2	0.2	CD
cord-002248-92pzqj35	120	8	%	%	NN
cord-002248-92pzqj35	120	9	TritonX-100	tritonx-100	NN
cord-002248-92pzqj35	120	10	for	for	IN
cord-002248-92pzqj35	120	11	15	15	CD
cord-002248-92pzqj35	120	12	min	min	NN
cord-002248-92pzqj35	120	13	and	and	CC
cord-002248-92pzqj35	120	14	blocked	block	VBD
cord-002248-92pzqj35	120	15	with	with	IN
cord-002248-92pzqj35	120	16	1	1	CD
cord-002248-92pzqj35	120	17	%	%	NN
cord-002248-92pzqj35	120	18	BSA	BSA	NNP
cord-002248-92pzqj35	120	19	in	in	IN
cord-002248-92pzqj35	120	20	PBS	PBS	NNP
cord-002248-92pzqj35	120	21	for	for	IN
cord-002248-92pzqj35	120	22	30	30	CD
cord-002248-92pzqj35	120	23	min	min	NN
cord-002248-92pzqj35	120	24	.	.	.
cord-002248-92pzqj35	121	1	After	after	IN
cord-002248-92pzqj35	121	2	the	the	DT
cord-002248-92pzqj35	121	3	blocking	blocking	NN
cord-002248-92pzqj35	121	4	,	,	,
cord-002248-92pzqj35	121	5	the	the	DT
cord-002248-92pzqj35	121	6	cells	cell	NNS
cord-002248-92pzqj35	121	7	were	be	VBD
cord-002248-92pzqj35	121	8	stained	stain	VBN
cord-002248-92pzqj35	121	9	with	with	IN
cord-002248-92pzqj35	121	10	primary	primary	JJ
cord-002248-92pzqj35	121	11	antibody	antibody	NN
cord-002248-92pzqj35	121	12	diluted	dilute	VBN
cord-002248-92pzqj35	121	13	with	with	IN
cord-002248-92pzqj35	121	14	the	the	DT
cord-002248-92pzqj35	121	15	blocking	block	VBG
cord-002248-92pzqj35	121	16	solution	solution	NN
cord-002248-92pzqj35	121	17	,	,	,
cord-002248-92pzqj35	121	18	followed	follow	VBN
cord-002248-92pzqj35	121	19	by	by	IN
cord-002248-92pzqj35	121	20	incubation	incubation	NN
cord-002248-92pzqj35	121	21	with	with	IN
cord-002248-92pzqj35	121	22	Alexa	Alexa	NNP
cord-002248-92pzqj35	121	23	Fluor	Fluor	NNP
cord-002248-92pzqj35	121	24	488	488	CD
cord-002248-92pzqj35	121	25	or	or	CC
cord-002248-92pzqj35	121	26	594-conjugated	594-conjugated	CD
cord-002248-92pzqj35	121	27	secondary	secondary	JJ
cord-002248-92pzqj35	121	28	antibodies	antibody	NNS
cord-002248-92pzqj35	121	29	(	(	-LRB-
cord-002248-92pzqj35	121	30	Molecular	Molecular	NNP
cord-002248-92pzqj35	121	31	Probes	Probes	NNPS
cord-002248-92pzqj35	121	32	)	)	-RRB-
cord-002248-92pzqj35	121	33	.	.	.
cord-002248-92pzqj35	122	1	Images	image	NNS
cord-002248-92pzqj35	122	2	were	be	VBD
cord-002248-92pzqj35	122	3	captured	capture	VBN
cord-002248-92pzqj35	122	4	by	by	IN
cord-002248-92pzqj35	122	5	a	a	DT
cord-002248-92pzqj35	122	6	Zeiss	Zeiss	NNP
cord-002248-92pzqj35	122	7	Axiophot	Axiophot	NNP
cord-002248-92pzqj35	122	8	2	2	CD
cord-002248-92pzqj35	122	9	fluorescence	fluorescence	NN
cord-002248-92pzqj35	122	10	microscopy	microscopy	NNS
cord-002248-92pzqj35	122	11	and	and	CC
cord-002248-92pzqj35	122	12	processed	process	VBN
cord-002248-92pzqj35	122	13	with	with	IN
cord-002248-92pzqj35	122	14	ImageJ	imagej	WDT
cord-002248-92pzqj35	122	15	software	software	NN
cord-002248-92pzqj35	122	16	[	[	-LRB-
cord-002248-92pzqj35	122	17	27	27	CD
cord-002248-92pzqj35	122	18	]	]	-RRB-
cord-002248-92pzqj35	122	19	.	.	.
cord-002248-92pzqj35	123	1	To	to	TO
cord-002248-92pzqj35	123	2	detect	detect	VB
cord-002248-92pzqj35	123	3	the	the	DT
cord-002248-92pzqj35	123	4	interaction	interaction	NN
cord-002248-92pzqj35	123	5	between	between	IN
cord-002248-92pzqj35	123	6	NSs	NSs	NNP
cord-002248-92pzqj35	123	7	and	and	CC
cord-002248-92pzqj35	123	8	p44	p44	NN
cord-002248-92pzqj35	123	9	,	,	,
cord-002248-92pzqj35	123	10	we	-PRON-	PRP
cord-002248-92pzqj35	123	11	infected	infect	VBD
cord-002248-92pzqj35	123	12	HeLa	HeLa	NNP
cord-002248-92pzqj35	123	13	cells	cell	NNS
cord-002248-92pzqj35	123	14	with	with	IN
cord-002248-92pzqj35	123	15	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	123	16	-	-	HYPH
cord-002248-92pzqj35	123	17	Flag	Flag	NNP
cord-002248-92pzqj35	123	18	,	,	,
cord-002248-92pzqj35	123	19	which	which	WDT
cord-002248-92pzqj35	123	20	expresses	express	VBZ
cord-002248-92pzqj35	123	21	NSs	NSs	NNP
cord-002248-92pzqj35	123	22	with	with	IN
cord-002248-92pzqj35	123	23	the	the	DT
cord-002248-92pzqj35	123	24	C	C	NNP
cord-002248-92pzqj35	123	25	-	-	HYPH
cord-002248-92pzqj35	123	26	terminal	terminal	NN
cord-002248-92pzqj35	123	27	Flag	Flag	NNP
cord-002248-92pzqj35	123	28	tag	tag	NN
cord-002248-92pzqj35	123	29	or	or	CC
cord-002248-92pzqj35	123	30	its	-PRON-	PRP$
cord-002248-92pzqj35	123	31	mutant	mutant	JJ
cord-002248-92pzqj35	123	32	viruses	virus	NNS
cord-002248-92pzqj35	123	33	at	at	IN
cord-002248-92pzqj35	123	34	an	an	DT
cord-002248-92pzqj35	123	35	m.o.i	m.o.i	NN
cord-002248-92pzqj35	123	36	.	.	NN
cord-002248-92pzqj35	123	37	of	of	IN
cord-002248-92pzqj35	123	38	3	3	CD
cord-002248-92pzqj35	123	39	.	.	.
cord-002248-92pzqj35	124	1	At	at	IN
cord-002248-92pzqj35	124	2	8	8	CD
cord-002248-92pzqj35	124	3	h	h	NN
cord-002248-92pzqj35	124	4	p.i	p.i	NNP
cord-002248-92pzqj35	124	5	.	.	NNP
cord-002248-92pzqj35	124	6	,	,	,
cord-002248-92pzqj35	124	7	the	the	DT
cord-002248-92pzqj35	124	8	cells	cell	NNS
cord-002248-92pzqj35	124	9	were	be	VBD
cord-002248-92pzqj35	124	10	lysed	lyse	VBN
cord-002248-92pzqj35	124	11	in	in	IN
cord-002248-92pzqj35	124	12	lysis	lysis	NN
cord-002248-92pzqj35	124	13	buffer	buffer	NN
cord-002248-92pzqj35	124	14	[	[	-LRB-
cord-002248-92pzqj35	124	15	50	50	CD
cord-002248-92pzqj35	124	16	mM	mm	CD
cord-002248-92pzqj35	124	17	Tris	Tris	NNP
cord-002248-92pzqj35	124	18	-	-	HYPH
cord-002248-92pzqj35	124	19	HCl	HCl	NNP
cord-002248-92pzqj35	124	20	,	,	,
cord-002248-92pzqj35	124	21	pH	pH	NNP
cord-002248-92pzqj35	124	22	7.6	7.6	CD
cord-002248-92pzqj35	124	23	,	,	,
cord-002248-92pzqj35	124	24	0.1	0.1	CD
cord-002248-92pzqj35	124	25	%	%	NN
cord-002248-92pzqj35	124	26	NP-40	NP-40	NNP
cord-002248-92pzqj35	124	27	,	,	,
cord-002248-92pzqj35	124	28	150	150	CD
cord-002248-92pzqj35	124	29	mM	mm	CD
cord-002248-92pzqj35	124	30	NaCl	nacl	NN
cord-002248-92pzqj35	124	31	,	,	,
cord-002248-92pzqj35	125	1	1	1	LS
cord-002248-92pzqj35	125	2	mM	mm	CD
cord-002248-92pzqj35	125	3	EDTA	edta	NN
cord-002248-92pzqj35	125	4	,	,	,
cord-002248-92pzqj35	125	5	protease	protease	NN
cord-002248-92pzqj35	125	6	inhibitors	inhibitor	NNS
cord-002248-92pzqj35	125	7	(	(	-LRB-
cord-002248-92pzqj35	125	8	Sigma	Sigma	NNP
cord-002248-92pzqj35	125	9	)	)	-RRB-
cord-002248-92pzqj35	125	10	,	,	,
cord-002248-92pzqj35	125	11	and	and	CC
cord-002248-92pzqj35	125	12	100	100	CD
cord-002248-92pzqj35	125	13	U	u	NN
cord-002248-92pzqj35	125	14	/	/	SYM
cord-002248-92pzqj35	125	15	ml	ml	NNP
cord-002248-92pzqj35	125	16	Benzonase	Benzonase	NNP
cord-002248-92pzqj35	125	17	(	(	-LRB-
cord-002248-92pzqj35	125	18	Sigma	Sigma	NNP
cord-002248-92pzqj35	125	19	)	)	-RRB-
cord-002248-92pzqj35	125	20	]	]	-RRB-
cord-002248-92pzqj35	125	21	.	.	.
cord-002248-92pzqj35	126	1	After	after	IN
cord-002248-92pzqj35	126	2	3	3	CD
cord-002248-92pzqj35	126	3	cycles	cycle	NNS
cord-002248-92pzqj35	126	4	of	of	IN
cord-002248-92pzqj35	126	5	freeze	freeze	NN
cord-002248-92pzqj35	126	6	-	-	HYPH
cord-002248-92pzqj35	126	7	thaw	thaw	NN
cord-002248-92pzqj35	126	8	,	,	,
cord-002248-92pzqj35	126	9	the	the	DT
cord-002248-92pzqj35	126	10	cell	cell	NN
cord-002248-92pzqj35	126	11	lysate	lysate	NN
cord-002248-92pzqj35	126	12	was	be	VBD
cord-002248-92pzqj35	126	13	cleared	clear	VBN
cord-002248-92pzqj35	126	14	by	by	IN
cord-002248-92pzqj35	126	15	centrifugation	centrifugation	NN
cord-002248-92pzqj35	126	16	at	at	IN
cord-002248-92pzqj35	126	17	4	4	CD
cord-002248-92pzqj35	126	18	°	°	NN
cord-002248-92pzqj35	126	19	C	c	NN
cord-002248-92pzqj35	126	20	and	and	CC
cord-002248-92pzqj35	126	21	100,000	100,000	CD
cord-002248-92pzqj35	126	22	x	x	SYM
cord-002248-92pzqj35	126	23	g	g	NN
cord-002248-92pzqj35	126	24	for	for	IN
cord-002248-92pzqj35	126	25	1	1	CD
cord-002248-92pzqj35	126	26	h	h	NN
cord-002248-92pzqj35	126	27	and	and	CC
cord-002248-92pzqj35	126	28	incubated	incubate	VBN
cord-002248-92pzqj35	126	29	with	with	IN
cord-002248-92pzqj35	126	30	Dynabeads	Dynabeads	NNP
cord-002248-92pzqj35	126	31	protein	protein	NN
cord-002248-92pzqj35	126	32	G	G	NNP
cord-002248-92pzqj35	126	33	(	(	-LRB-
cord-002248-92pzqj35	126	34	Life	Life	NNP
cord-002248-92pzqj35	126	35	Technologies	Technologies	NNPS
cord-002248-92pzqj35	126	36	)	)	-RRB-
cord-002248-92pzqj35	126	37	conjugated	conjugate	VBN
cord-002248-92pzqj35	126	38	with	with	IN
cord-002248-92pzqj35	126	39	anti	anti	JJ
cord-002248-92pzqj35	126	40	-	-	JJ
cord-002248-92pzqj35	126	41	GTF2H2	gtf2h2	JJ
cord-002248-92pzqj35	126	42	(	(	-LRB-
cord-002248-92pzqj35	126	43	p44	p44	NN
cord-002248-92pzqj35	126	44	)	)	-RRB-
cord-002248-92pzqj35	126	45	mouse	mouse	NN
cord-002248-92pzqj35	126	46	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	126	47	antibody	antibody	NN
cord-002248-92pzqj35	126	48	or	or	CC
cord-002248-92pzqj35	126	49	H2	H2	NNP
cord-002248-92pzqj35	126	50	K	K	NNP
cord-002248-92pzqj35	126	51	antibody	antibody	NN
cord-002248-92pzqj35	126	52	according	accord	VBG
cord-002248-92pzqj35	126	53	to	to	IN
cord-002248-92pzqj35	126	54	the	the	DT
cord-002248-92pzqj35	126	55	manufacturer	manufacturer	NN
cord-002248-92pzqj35	126	56	's	's	POS
cord-002248-92pzqj35	126	57	protocol	protocol	NN
cord-002248-92pzqj35	126	58	.	.	.
cord-002248-92pzqj35	127	1	Precipitates	precipitate	NNS
cord-002248-92pzqj35	127	2	were	be	VBD
cord-002248-92pzqj35	127	3	washed	wash	VBN
cord-002248-92pzqj35	127	4	with	with	IN
cord-002248-92pzqj35	127	5	the	the	DT
cord-002248-92pzqj35	127	6	lysis	lysis	NN
cord-002248-92pzqj35	127	7	buffer	buffer	NN
cord-002248-92pzqj35	127	8	with	with	IN
cord-002248-92pzqj35	127	9	0.1	0.1	CD
cord-002248-92pzqj35	127	10	%	%	NN
cord-002248-92pzqj35	127	11	Tween	Tween	NNP
cord-002248-92pzqj35	127	12	20	20	CD
cord-002248-92pzqj35	127	13	and	and	CC
cord-002248-92pzqj35	127	14	analyzed	analyze	VBN
cord-002248-92pzqj35	127	15	by	by	IN
cord-002248-92pzqj35	127	16	Western	western	JJ
cord-002248-92pzqj35	127	17	blotting	blotting	NN
cord-002248-92pzqj35	127	18	using	use	VBG
cord-002248-92pzqj35	127	19	the	the	DT
cord-002248-92pzqj35	127	20	anti	anti	JJ
cord-002248-92pzqj35	127	21	-	-	JJ
cord-002248-92pzqj35	127	22	p44	p44	JJ
cord-002248-92pzqj35	127	23	goat	goat	NN
cord-002248-92pzqj35	127	24	polyclonal	polyclonal	JJ
cord-002248-92pzqj35	127	25	,	,	,
cord-002248-92pzqj35	127	26	and	and	CC
cord-002248-92pzqj35	127	27	anti	anti	JJ
cord-002248-92pzqj35	127	28	-	-	JJ
cord-002248-92pzqj35	127	29	p44	p44	JJ
cord-002248-92pzqj35	127	30	mouse	mouse	NN
cord-002248-92pzqj35	127	31	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	127	32	and	and	CC
cord-002248-92pzqj35	127	33	anti	anti	JJ
cord-002248-92pzqj35	127	34	-	-	JJ
cord-002248-92pzqj35	127	35	Flag	flag	JJ
cord-002248-92pzqj35	127	36	mouse	mouse	NN
cord-002248-92pzqj35	127	37	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	127	38	antibodies	antibody	NNS
cord-002248-92pzqj35	127	39	.	.	.
cord-002248-92pzqj35	128	1	To	to	TO
cord-002248-92pzqj35	128	2	detect	detect	VB
cord-002248-92pzqj35	128	3	the	the	DT
cord-002248-92pzqj35	128	4	interaction	interaction	NN
cord-002248-92pzqj35	128	5	between	between	IN
cord-002248-92pzqj35	128	6	NSs	NSs	NNP
cord-002248-92pzqj35	128	7	and	and	CC
cord-002248-92pzqj35	128	8	SAP30	SAP30	NNP
cord-002248-92pzqj35	128	9	,	,	,
cord-002248-92pzqj35	128	10	we	-PRON-	PRP
cord-002248-92pzqj35	128	11	transfected	transfecte	VBD
cord-002248-92pzqj35	128	12	HeLa	HeLa	NNP
cord-002248-92pzqj35	128	13	cells	cell	NNS
cord-002248-92pzqj35	128	14	with	with	IN
cord-002248-92pzqj35	128	15	pCAGGS	pCAGGS	NNP
cord-002248-92pzqj35	128	16	-	-	HYPH
cord-002248-92pzqj35	128	17	V5-SAP30	V5-SAP30	NNP
cord-002248-92pzqj35	128	18	which	which	WDT
cord-002248-92pzqj35	128	19	encodes	encode	VBZ
cord-002248-92pzqj35	128	20	human	human	JJ
cord-002248-92pzqj35	128	21	SAP30	SAP30	NNP
cord-002248-92pzqj35	128	22	carrying	carry	VBG
cord-002248-92pzqj35	128	23	an	an	DT
cord-002248-92pzqj35	128	24	N	n	CD
cord-002248-92pzqj35	128	25	-	-	HYPH
cord-002248-92pzqj35	128	26	terminus	terminus	NN
cord-002248-92pzqj35	128	27	V5	v5	NN
cord-002248-92pzqj35	128	28	tag	tag	NN
cord-002248-92pzqj35	128	29	by	by	IN
cord-002248-92pzqj35	128	30	using	use	VBG
cord-002248-92pzqj35	128	31	FuGENE	fugene	JJ
cord-002248-92pzqj35	128	32	HD	hd	NN
cord-002248-92pzqj35	128	33	transfection	transfection	NN
cord-002248-92pzqj35	128	34	reagent	reagent	NN
cord-002248-92pzqj35	128	35	(	(	-LRB-
cord-002248-92pzqj35	128	36	Promega	Promega	NNP
cord-002248-92pzqj35	128	37	)	)	-RRB-
cord-002248-92pzqj35	128	38	.	.	.
cord-002248-92pzqj35	129	1	At	at	IN
cord-002248-92pzqj35	129	2	16	16	CD
cord-002248-92pzqj35	129	3	h	h	NN
cord-002248-92pzqj35	129	4	post	post	NN
cord-002248-92pzqj35	129	5	transfection	transfection	NN
cord-002248-92pzqj35	129	6	,	,	,
cord-002248-92pzqj35	129	7	the	the	DT
cord-002248-92pzqj35	129	8	cells	cell	NNS
cord-002248-92pzqj35	129	9	were	be	VBD
cord-002248-92pzqj35	129	10	infected	infect	VBN
cord-002248-92pzqj35	129	11	with	with	IN
cord-002248-92pzqj35	129	12	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	129	13	-	-	HYPH
cord-002248-92pzqj35	129	14	Flag	Flag	NNP
cord-002248-92pzqj35	129	15	or	or	CC
cord-002248-92pzqj35	129	16	its	-PRON-	PRP$
cord-002248-92pzqj35	129	17	mutant	mutant	JJ
cord-002248-92pzqj35	129	18	viruses	virus	NNS
cord-002248-92pzqj35	129	19	.	.	.
cord-002248-92pzqj35	130	1	The	the	DT
cord-002248-92pzqj35	130	2	cells	cell	NNS
cord-002248-92pzqj35	130	3	were	be	VBD
cord-002248-92pzqj35	130	4	lysed	lyse	VBN
cord-002248-92pzqj35	130	5	with	with	IN
cord-002248-92pzqj35	130	6	lysis	lysis	NN
cord-002248-92pzqj35	130	7	buffer	buffer	NN
cord-002248-92pzqj35	130	8	(	(	-LRB-
cord-002248-92pzqj35	130	9	50	50	CD
cord-002248-92pzqj35	130	10	mM	mM	NNP
cord-002248-92pzqj35	130	11	Tris	Tris	NNP
cord-002248-92pzqj35	130	12	-	-	HYPH
cord-002248-92pzqj35	130	13	HCl	HCl	NNP
cord-002248-92pzqj35	130	14	,	,	,
cord-002248-92pzqj35	130	15	pH	pH	NNP
cord-002248-92pzqj35	130	16	7.5	7.5	CD
cord-002248-92pzqj35	130	17	,	,	,
cord-002248-92pzqj35	130	18	100	100	CD
cord-002248-92pzqj35	130	19	mM	mm	CD
cord-002248-92pzqj35	130	20	NaCl	nacl	NN
cord-002248-92pzqj35	130	21	,	,	,
cord-002248-92pzqj35	130	22	1	1	CD
cord-002248-92pzqj35	130	23	%	%	NN
cord-002248-92pzqj35	130	24	NP-40	NP-40	NNP
cord-002248-92pzqj35	130	25	,	,	,
cord-002248-92pzqj35	130	26	1	1	CD
cord-002248-92pzqj35	130	27	mM	mm	CD
cord-002248-92pzqj35	130	28	EDTA	EDTA	NNP
cord-002248-92pzqj35	130	29	,	,	,
cord-002248-92pzqj35	130	30	and	and	CC
cord-002248-92pzqj35	130	31	protease	protease	JJ
cord-002248-92pzqj35	130	32	inhibitor	inhibitor	NN
cord-002248-92pzqj35	130	33	cocktail	cocktail	NN
cord-002248-92pzqj35	130	34	)	)	-RRB-
cord-002248-92pzqj35	130	35	[	[	-LRB-
cord-002248-92pzqj35	130	36	11	11	CD
cord-002248-92pzqj35	130	37	]	]	-RRB-
cord-002248-92pzqj35	130	38	at	at	IN
cord-002248-92pzqj35	130	39	8	8	CD
cord-002248-92pzqj35	130	40	h	h	NN
cord-002248-92pzqj35	130	41	p.i	p.i	NNP
cord-002248-92pzqj35	130	42	.	.	.
cord-002248-92pzqj35	131	1	The	the	DT
cord-002248-92pzqj35	131	2	cell	cell	NN
cord-002248-92pzqj35	131	3	lysate	lysate	NN
cord-002248-92pzqj35	131	4	was	be	VBD
cord-002248-92pzqj35	131	5	cleared	clear	VBN
cord-002248-92pzqj35	131	6	by	by	IN
cord-002248-92pzqj35	131	7	centrifuge	centrifuge	NN
cord-002248-92pzqj35	131	8	at	at	IN
cord-002248-92pzqj35	131	9	21,000	21,000	CD
cord-002248-92pzqj35	131	10	x	x	SYM
cord-002248-92pzqj35	131	11	g	g	NN
cord-002248-92pzqj35	131	12	and	and	CC
cord-002248-92pzqj35	131	13	4	4	CD
cord-002248-92pzqj35	131	14	°	°	NN
cord-002248-92pzqj35	131	15	C	c	NN
cord-002248-92pzqj35	131	16	for	for	IN
cord-002248-92pzqj35	131	17	15	15	CD
cord-002248-92pzqj35	131	18	min	min	NN
cord-002248-92pzqj35	131	19	and	and	CC
cord-002248-92pzqj35	131	20	incubated	incubate	VBN
cord-002248-92pzqj35	131	21	with	with	IN
cord-002248-92pzqj35	131	22	Anti	Anti	NNP
cord-002248-92pzqj35	131	23	-	-	JJ
cord-002248-92pzqj35	131	24	V5-tag	v5-tag	JJ
cord-002248-92pzqj35	131	25	mAb	mab	NN
cord-002248-92pzqj35	131	26	-	-	HYPH
cord-002248-92pzqj35	131	27	Magnetic	magnetic	JJ
cord-002248-92pzqj35	131	28	Beads	bead	NNS
cord-002248-92pzqj35	131	29	(	(	-LRB-
cord-002248-92pzqj35	131	30	MBL	MBL	NNP
cord-002248-92pzqj35	131	31	International	International	NNP
cord-002248-92pzqj35	131	32	)	)	-RRB-
cord-002248-92pzqj35	131	33	according	accord	VBG
cord-002248-92pzqj35	131	34	to	to	IN
cord-002248-92pzqj35	131	35	the	the	DT
cord-002248-92pzqj35	131	36	manufacturer	manufacturer	NN
cord-002248-92pzqj35	131	37	's	's	POS
cord-002248-92pzqj35	131	38	protocol	protocol	NN
cord-002248-92pzqj35	131	39	.	.	.
cord-002248-92pzqj35	132	1	Precipitates	precipitate	NNS
cord-002248-92pzqj35	132	2	were	be	VBD
cord-002248-92pzqj35	132	3	washed	wash	VBN
cord-002248-92pzqj35	132	4	with	with	IN
cord-002248-92pzqj35	132	5	the	the	DT
cord-002248-92pzqj35	132	6	lysis	lysis	NN
cord-002248-92pzqj35	132	7	buffer	buffer	NN
cord-002248-92pzqj35	132	8	containing	contain	VBG
cord-002248-92pzqj35	132	9	450	450	CD
cord-002248-92pzqj35	132	10	mM	mm	CD
cord-002248-92pzqj35	132	11	NaCl	nacl	NN
cord-002248-92pzqj35	132	12	and	and	CC
cord-002248-92pzqj35	132	13	analyzed	analyze	VBN
cord-002248-92pzqj35	132	14	by	by	IN
cord-002248-92pzqj35	132	15	Western	western	JJ
cord-002248-92pzqj35	132	16	blotting	blotting	NN
cord-002248-92pzqj35	132	17	by	by	IN
cord-002248-92pzqj35	132	18	using	use	VBG
cord-002248-92pzqj35	132	19	anti	anti	JJ
cord-002248-92pzqj35	132	20	-	-	JJ
cord-002248-92pzqj35	132	21	V5	v5	JJ
cord-002248-92pzqj35	132	22	tag	tag	NN
cord-002248-92pzqj35	132	23	rabbit	rabbit	NN
cord-002248-92pzqj35	132	24	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	132	25	and	and	CC
cord-002248-92pzqj35	132	26	anti	anti	JJ
cord-002248-92pzqj35	132	27	-	-	JJ
cord-002248-92pzqj35	132	28	Flag	flag	JJ
cord-002248-92pzqj35	132	29	mouse	mouse	NN
cord-002248-92pzqj35	132	30	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	132	31	antibodies	antibody	NNS
cord-002248-92pzqj35	132	32	.	.	.
cord-002248-92pzqj35	133	1	For	for	IN
cord-002248-92pzqj35	133	2	detection	detection	NN
cord-002248-92pzqj35	133	3	of	of	IN
cord-002248-92pzqj35	133	4	interaction	interaction	NN
cord-002248-92pzqj35	133	5	between	between	IN
cord-002248-92pzqj35	133	6	NSs	ns	NNS
cord-002248-92pzqj35	133	7	and	and	CC
cord-002248-92pzqj35	133	8	p62	p62	NN
cord-002248-92pzqj35	133	9	,	,	,
cord-002248-92pzqj35	133	10	HeLa	HeLa	NNP
cord-002248-92pzqj35	133	11	cells	cell	NNS
cord-002248-92pzqj35	133	12	were	be	VBD
cord-002248-92pzqj35	133	13	infected	infect	VBN
cord-002248-92pzqj35	133	14	with	with	IN
cord-002248-92pzqj35	133	15	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	133	16	-	-	HYPH
cord-002248-92pzqj35	133	17	Flag	Flag	NNP
cord-002248-92pzqj35	133	18	or	or	CC
cord-002248-92pzqj35	133	19	its	-PRON-	PRP$
cord-002248-92pzqj35	133	20	mutant	mutant	JJ
cord-002248-92pzqj35	133	21	viruses	virus	NNS
cord-002248-92pzqj35	133	22	at	at	IN
cord-002248-92pzqj35	133	23	an	an	DT
cord-002248-92pzqj35	133	24	m.o.i	m.o.i	NN
cord-002248-92pzqj35	133	25	.	.	NN
cord-002248-92pzqj35	133	26	of	of	IN
cord-002248-92pzqj35	133	27	3	3	CD
cord-002248-92pzqj35	133	28	.	.	.
cord-002248-92pzqj35	134	1	At	at	IN
cord-002248-92pzqj35	134	2	5	5	CD
cord-002248-92pzqj35	134	3	h	h	NN
cord-002248-92pzqj35	134	4	p.i	p.i	NNP
cord-002248-92pzqj35	134	5	.	.	NNP
cord-002248-92pzqj35	134	6	,	,	,
cord-002248-92pzqj35	134	7	the	the	DT
cord-002248-92pzqj35	134	8	cells	cell	NNS
cord-002248-92pzqj35	134	9	were	be	VBD
cord-002248-92pzqj35	134	10	lysed	lyse	VBN
cord-002248-92pzqj35	134	11	in	in	IN
cord-002248-92pzqj35	134	12	lysis	lysis	NN
cord-002248-92pzqj35	134	13	buffer	buffer	NN
cord-002248-92pzqj35	134	14	[	[	-LRB-
cord-002248-92pzqj35	134	15	20	20	CD
cord-002248-92pzqj35	134	16	mM	mM	NNP
cord-002248-92pzqj35	134	17	Tris	Tris	NNP
cord-002248-92pzqj35	134	18	-	-	HYPH
cord-002248-92pzqj35	134	19	HCl	HCl	NNP
cord-002248-92pzqj35	134	20	,	,	,
cord-002248-92pzqj35	134	21	pH	pH	NNP
cord-002248-92pzqj35	134	22	7.6	7.6	CD
cord-002248-92pzqj35	134	23	,	,	,
cord-002248-92pzqj35	134	24	0.1	0.1	CD
cord-002248-92pzqj35	134	25	%	%	NN
cord-002248-92pzqj35	134	26	TritonX-100	tritonx-100	NN
cord-002248-92pzqj35	134	27	,	,	,
cord-002248-92pzqj35	134	28	150	150	CD
cord-002248-92pzqj35	134	29	mM	mm	CD
cord-002248-92pzqj35	134	30	NaCl	nacl	NN
cord-002248-92pzqj35	134	31	,	,	,
cord-002248-92pzqj35	134	32	1	1	CD
cord-002248-92pzqj35	134	33	mM	mm	CD
cord-002248-92pzqj35	134	34	EDTA	edta	NN
cord-002248-92pzqj35	134	35	,	,	,
cord-002248-92pzqj35	134	36	protease	protease	NN
cord-002248-92pzqj35	134	37	inhibitors	inhibitor	NNS
cord-002248-92pzqj35	134	38	(	(	-LRB-
cord-002248-92pzqj35	134	39	Sigma	Sigma	NNP
cord-002248-92pzqj35	134	40	)	)	-RRB-
cord-002248-92pzqj35	134	41	,	,	,
cord-002248-92pzqj35	134	42	and	and	CC
cord-002248-92pzqj35	134	43	100	100	CD
cord-002248-92pzqj35	134	44	U	u	NN
cord-002248-92pzqj35	134	45	/	/	SYM
cord-002248-92pzqj35	134	46	ml	ml	NNP
cord-002248-92pzqj35	134	47	Benzonase	Benzonase	NNP
cord-002248-92pzqj35	134	48	(	(	-LRB-
cord-002248-92pzqj35	134	49	Sigma	Sigma	NNP
cord-002248-92pzqj35	134	50	)	)	-RRB-
cord-002248-92pzqj35	134	51	]	]	-RRB-
cord-002248-92pzqj35	134	52	[	[	-LRB-
cord-002248-92pzqj35	134	53	13	13	CD
cord-002248-92pzqj35	134	54	]	]	-RRB-
cord-002248-92pzqj35	134	55	.	.	.
cord-002248-92pzqj35	135	1	After	after	IN
cord-002248-92pzqj35	135	2	3	3	CD
cord-002248-92pzqj35	135	3	cycles	cycle	NNS
cord-002248-92pzqj35	135	4	of	of	IN
cord-002248-92pzqj35	135	5	freeze	freeze	NN
cord-002248-92pzqj35	135	6	-	-	HYPH
cord-002248-92pzqj35	135	7	thaw	thaw	NN
cord-002248-92pzqj35	135	8	,	,	,
cord-002248-92pzqj35	135	9	the	the	DT
cord-002248-92pzqj35	135	10	cell	cell	NN
cord-002248-92pzqj35	135	11	lysate	lysate	NN
cord-002248-92pzqj35	135	12	was	be	VBD
cord-002248-92pzqj35	135	13	cleared	clear	VBN
cord-002248-92pzqj35	135	14	by	by	IN
cord-002248-92pzqj35	135	15	centrifugation	centrifugation	NN
cord-002248-92pzqj35	135	16	at	at	IN
cord-002248-92pzqj35	135	17	4	4	CD
cord-002248-92pzqj35	135	18	°	°	NN
cord-002248-92pzqj35	135	19	C	c	NN
cord-002248-92pzqj35	135	20	and	and	CC
cord-002248-92pzqj35	135	21	100,000	100,000	CD
cord-002248-92pzqj35	135	22	x	x	SYM
cord-002248-92pzqj35	135	23	g	g	NN
cord-002248-92pzqj35	135	24	for	for	IN
cord-002248-92pzqj35	135	25	1	1	CD
cord-002248-92pzqj35	135	26	h	h	NN
cord-002248-92pzqj35	135	27	and	and	CC
cord-002248-92pzqj35	135	28	incubated	incubate	VBN
cord-002248-92pzqj35	135	29	with	with	IN
cord-002248-92pzqj35	135	30	Dynabeads	Dynabeads	NNP
cord-002248-92pzqj35	135	31	protein	protein	NN
cord-002248-92pzqj35	135	32	G	g	NN
cord-002248-92pzqj35	135	33	conjugated	conjugate	VBN
cord-002248-92pzqj35	135	34	with	with	IN
cord-002248-92pzqj35	135	35	anti	anti	JJ
cord-002248-92pzqj35	135	36	-	-	JJ
cord-002248-92pzqj35	135	37	GTF2H1	gtf2h1	JJ
cord-002248-92pzqj35	135	38	(	(	-LRB-
cord-002248-92pzqj35	135	39	p62	p62	NN
cord-002248-92pzqj35	135	40	)	)	-RRB-
cord-002248-92pzqj35	135	41	mouse	mouse	NN
cord-002248-92pzqj35	135	42	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	135	43	antibody	antibody	NN
cord-002248-92pzqj35	135	44	according	accord	VBG
cord-002248-92pzqj35	135	45	to	to	IN
cord-002248-92pzqj35	135	46	the	the	DT
cord-002248-92pzqj35	135	47	manufacturer	manufacturer	NN
cord-002248-92pzqj35	135	48	's	's	POS
cord-002248-92pzqj35	135	49	protocol	protocol	NN
cord-002248-92pzqj35	135	50	.	.	.
cord-002248-92pzqj35	136	1	Precipitates	precipitate	NNS
cord-002248-92pzqj35	136	2	were	be	VBD
cord-002248-92pzqj35	136	3	analyzed	analyze	VBN
cord-002248-92pzqj35	136	4	by	by	IN
cord-002248-92pzqj35	136	5	Western	western	JJ
cord-002248-92pzqj35	136	6	blotting	blotting	NN
cord-002248-92pzqj35	136	7	using	use	VBG
cord-002248-92pzqj35	136	8	the	the	DT
cord-002248-92pzqj35	136	9	anti	anti	JJ
cord-002248-92pzqj35	136	10	-	-	JJ
cord-002248-92pzqj35	136	11	p62	p62	JJ
cord-002248-92pzqj35	136	12	mouse	mouse	NN
cord-002248-92pzqj35	136	13	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	136	14	and	and	CC
cord-002248-92pzqj35	136	15	anti	anti	JJ
cord-002248-92pzqj35	136	16	-	-	JJ
cord-002248-92pzqj35	136	17	Flag	flag	JJ
cord-002248-92pzqj35	136	18	mouse	mouse	NN
cord-002248-92pzqj35	136	19	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	136	20	antibodies	antibody	NNS
cord-002248-92pzqj35	136	21	.	.	.
cord-002248-92pzqj35	137	1	To	to	TO
cord-002248-92pzqj35	137	2	detect	detect	VB
cord-002248-92pzqj35	137	3	the	the	DT
cord-002248-92pzqj35	137	4	interaction	interaction	NN
cord-002248-92pzqj35	137	5	between	between	IN
cord-002248-92pzqj35	137	6	NSs	NSs	NNP
cord-002248-92pzqj35	137	7	and	and	CC
cord-002248-92pzqj35	137	8	FBXO	FBXO	NNP
cord-002248-92pzqj35	137	9	,	,	,
cord-002248-92pzqj35	137	10	we	-PRON-	PRP
cord-002248-92pzqj35	137	11	transfected	transfecte	VBD
cord-002248-92pzqj35	137	12	HeLa	HeLa	NNP
cord-002248-92pzqj35	137	13	cells	cell	NNS
cord-002248-92pzqj35	137	14	with	with	IN
cord-002248-92pzqj35	137	15	pCAGGS	pcaggs	NN
cord-002248-92pzqj35	137	16	-	-	HYPH
cord-002248-92pzqj35	137	17	V5-FBXO3/1	V5-FBXO3/1	NNP
cord-002248-92pzqj35	137	18	,	,	,
cord-002248-92pzqj35	137	19	which	which	WDT
cord-002248-92pzqj35	137	20	encodes	encode	VBZ
cord-002248-92pzqj35	137	21	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	137	22	carrying	carry	VBG
cord-002248-92pzqj35	137	23	an	an	DT
cord-002248-92pzqj35	137	24	N	n	CD
cord-002248-92pzqj35	137	25	-	-	HYPH
cord-002248-92pzqj35	137	26	terminus	terminus	NN
cord-002248-92pzqj35	137	27	V5	v5	NN
cord-002248-92pzqj35	137	28	tag	tag	NN
cord-002248-92pzqj35	137	29	,	,	,
cord-002248-92pzqj35	137	30	by	by	IN
cord-002248-92pzqj35	137	31	using	use	VBG
cord-002248-92pzqj35	137	32	FuGENE	fugene	JJ
cord-002248-92pzqj35	137	33	HD	hd	NN
cord-002248-92pzqj35	137	34	transfection	transfection	NN
cord-002248-92pzqj35	137	35	reagent	reagent	NN
cord-002248-92pzqj35	137	36	.	.	.
cord-002248-92pzqj35	138	1	At	at	IN
cord-002248-92pzqj35	138	2	16	16	CD
cord-002248-92pzqj35	138	3	h	h	NN
cord-002248-92pzqj35	138	4	post	post	NN
cord-002248-92pzqj35	138	5	transfection	transfection	NN
cord-002248-92pzqj35	138	6	,	,	,
cord-002248-92pzqj35	138	7	the	the	DT
cord-002248-92pzqj35	138	8	cells	cell	NNS
cord-002248-92pzqj35	138	9	were	be	VBD
cord-002248-92pzqj35	138	10	infected	infect	VBN
cord-002248-92pzqj35	138	11	with	with	IN
cord-002248-92pzqj35	138	12	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	138	13	-	-	HYPH
cord-002248-92pzqj35	138	14	Flag	Flag	NNP
cord-002248-92pzqj35	138	15	or	or	CC
cord-002248-92pzqj35	138	16	its	-PRON-	PRP$
cord-002248-92pzqj35	138	17	mutant	mutant	JJ
cord-002248-92pzqj35	138	18	viruses	virus	NNS
cord-002248-92pzqj35	138	19	and	and	CC
cord-002248-92pzqj35	138	20	lysed	lyse	VBN
cord-002248-92pzqj35	138	21	with	with	IN
cord-002248-92pzqj35	138	22	lysis	lysis	NN
cord-002248-92pzqj35	138	23	buffer	buffer	NN
cord-002248-92pzqj35	138	24	(	(	-LRB-
cord-002248-92pzqj35	138	25	50	50	CD
cord-002248-92pzqj35	138	26	mM	mM	NNP
cord-002248-92pzqj35	138	27	Tris	Tris	NNP
cord-002248-92pzqj35	138	28	-	-	HYPH
cord-002248-92pzqj35	138	29	HCl	HCl	NNP
cord-002248-92pzqj35	138	30	,	,	,
cord-002248-92pzqj35	138	31	pH	pH	NNP
cord-002248-92pzqj35	138	32	7.5	7.5	CD
cord-002248-92pzqj35	138	33	,	,	,
cord-002248-92pzqj35	138	34	0.2	0.2	CD
cord-002248-92pzqj35	138	35	%	%	NN
cord-002248-92pzqj35	138	36	NP-40	NP-40	NNP
cord-002248-92pzqj35	138	37	,	,	,
cord-002248-92pzqj35	138	38	5	5	CD
cord-002248-92pzqj35	138	39	%	%	NN
cord-002248-92pzqj35	138	40	glycerol	glycerol	NN
cord-002248-92pzqj35	138	41	,	,	,
cord-002248-92pzqj35	138	42	100	100	CD
cord-002248-92pzqj35	138	43	mM	mm	CD
cord-002248-92pzqj35	138	44	NaCl	nacl	NN
cord-002248-92pzqj35	138	45	,	,	,
cord-002248-92pzqj35	138	46	1.5	1.5	CD
cord-002248-92pzqj35	138	47	mM	mm	CD
cord-002248-92pzqj35	138	48	MgCl	MgCl	NNP
cord-002248-92pzqj35	138	49	2	2	CD
cord-002248-92pzqj35	138	50	,	,	,
cord-002248-92pzqj35	138	51	and	and	CC
cord-002248-92pzqj35	138	52	protease	protease	JJ
cord-002248-92pzqj35	138	53	inhibitor	inhibitor	NN
cord-002248-92pzqj35	138	54	cocktail	cocktail	NN
cord-002248-92pzqj35	138	55	)	)	-RRB-
cord-002248-92pzqj35	139	1	[	[	-LRB-
cord-002248-92pzqj35	139	2	14	14	CD
cord-002248-92pzqj35	139	3	]	]	-RRB-
cord-002248-92pzqj35	139	4	at	at	IN
cord-002248-92pzqj35	139	5	5	5	CD
cord-002248-92pzqj35	139	6	h	h	NN
cord-002248-92pzqj35	139	7	p.i	p.i	NNP
cord-002248-92pzqj35	139	8	.	.	.
cord-002248-92pzqj35	140	1	The	the	DT
cord-002248-92pzqj35	140	2	cell	cell	NN
cord-002248-92pzqj35	140	3	lysate	lysate	NN
cord-002248-92pzqj35	140	4	was	be	VBD
cord-002248-92pzqj35	140	5	cleared	clear	VBN
cord-002248-92pzqj35	140	6	by	by	IN
cord-002248-92pzqj35	140	7	centrifugation	centrifugation	NN
cord-002248-92pzqj35	140	8	at	at	IN
cord-002248-92pzqj35	140	9	21,000	21,000	CD
cord-002248-92pzqj35	140	10	x	x	SYM
cord-002248-92pzqj35	140	11	g	g	NN
cord-002248-92pzqj35	140	12	and	and	CC
cord-002248-92pzqj35	140	13	4	4	CD
cord-002248-92pzqj35	140	14	°	°	NN
cord-002248-92pzqj35	140	15	C	c	NN
cord-002248-92pzqj35	140	16	for	for	IN
cord-002248-92pzqj35	140	17	15	15	CD
cord-002248-92pzqj35	140	18	min	min	NN
cord-002248-92pzqj35	140	19	and	and	CC
cord-002248-92pzqj35	140	20	incubated	incubate	VBN
cord-002248-92pzqj35	140	21	with	with	IN
cord-002248-92pzqj35	140	22	Anti	Anti	NNP
cord-002248-92pzqj35	140	23	-	-	JJ
cord-002248-92pzqj35	140	24	V5-tag	v5-tag	JJ
cord-002248-92pzqj35	140	25	mAb	mab	NN
cord-002248-92pzqj35	140	26	-	-	HYPH
cord-002248-92pzqj35	140	27	Magnetic	magnetic	JJ
cord-002248-92pzqj35	140	28	Beads	bead	NNS
cord-002248-92pzqj35	140	29	(	(	-LRB-
cord-002248-92pzqj35	140	30	MBL	MBL	NNP
cord-002248-92pzqj35	140	31	International	International	NNP
cord-002248-92pzqj35	140	32	)	)	-RRB-
cord-002248-92pzqj35	140	33	according	accord	VBG
cord-002248-92pzqj35	140	34	to	to	IN
cord-002248-92pzqj35	140	35	the	the	DT
cord-002248-92pzqj35	140	36	manufacturer	manufacturer	NN
cord-002248-92pzqj35	140	37	's	's	POS
cord-002248-92pzqj35	140	38	protocol	protocol	NN
cord-002248-92pzqj35	140	39	.	.	.
cord-002248-92pzqj35	141	1	Precipitates	precipitate	NNS
cord-002248-92pzqj35	141	2	were	be	VBD
cord-002248-92pzqj35	141	3	washed	wash	VBN
cord-002248-92pzqj35	141	4	with	with	IN
cord-002248-92pzqj35	141	5	the	the	DT
cord-002248-92pzqj35	141	6	lysis	lysis	NN
cord-002248-92pzqj35	141	7	buffer	buffer	NN
cord-002248-92pzqj35	141	8	and	and	CC
cord-002248-92pzqj35	141	9	analyzed	analyze	VBN
cord-002248-92pzqj35	141	10	by	by	IN
cord-002248-92pzqj35	141	11	Western	western	JJ
cord-002248-92pzqj35	141	12	blotting	blotting	NN
cord-002248-92pzqj35	141	13	by	by	IN
cord-002248-92pzqj35	141	14	using	use	VBG
cord-002248-92pzqj35	141	15	the	the	DT
cord-002248-92pzqj35	141	16	anti	anti	JJ
cord-002248-92pzqj35	141	17	-	-	JJ
cord-002248-92pzqj35	141	18	V5	v5	JJ
cord-002248-92pzqj35	141	19	tag	tag	NN
cord-002248-92pzqj35	141	20	rabbit	rabbit	NN
cord-002248-92pzqj35	141	21	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	141	22	and	and	CC
cord-002248-92pzqj35	141	23	anti	anti	JJ
cord-002248-92pzqj35	141	24	-	-	JJ
cord-002248-92pzqj35	141	25	Flag	flag	JJ
cord-002248-92pzqj35	141	26	mouse	mouse	NN
cord-002248-92pzqj35	141	27	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	141	28	antibodies	antibody	NNS
cord-002248-92pzqj35	141	29	.	.	.
cord-002248-92pzqj35	142	1	HeLa	HeLa	NNP
cord-002248-92pzqj35	142	2	cells	cell	NNS
cord-002248-92pzqj35	142	3	prepared	prepare	VBN
cord-002248-92pzqj35	142	4	in	in	IN
cord-002248-92pzqj35	142	5	12-well	12-well	CD
cord-002248-92pzqj35	142	6	plates	plate	NNS
cord-002248-92pzqj35	142	7	were	be	VBD
cord-002248-92pzqj35	142	8	transfected	transfecte	VBN
cord-002248-92pzqj35	142	9	with	with	IN
cord-002248-92pzqj35	142	10	0.25	0.25	CD
cord-002248-92pzqj35	142	11	μg	μg	CD
cord-002248-92pzqj35	142	12	of	of	IN
cord-002248-92pzqj35	142	13	the	the	DT
cord-002248-92pzqj35	142	14	pCAGGS	pcaggs	NN
cord-002248-92pzqj35	142	15	-	-	HYPH
cord-002248-92pzqj35	142	16	based	base	VBN
cord-002248-92pzqj35	142	17	plasmid	plasmid	NN
cord-002248-92pzqj35	142	18	encoding	encoding	NN
cord-002248-92pzqj35	142	19	either	either	CC
cord-002248-92pzqj35	142	20	NSs	ns	NNS
cord-002248-92pzqj35	142	21	or	or	CC
cord-002248-92pzqj35	142	22	mutant	mutant	JJ
cord-002248-92pzqj35	142	23	NSs	ns	NNS
cord-002248-92pzqj35	142	24	or	or	CC
cord-002248-92pzqj35	142	25	an	an	DT
cord-002248-92pzqj35	142	26	empty	empty	JJ
cord-002248-92pzqj35	142	27	vector	vector	NN
cord-002248-92pzqj35	142	28	along	along	IN
cord-002248-92pzqj35	142	29	with	with	IN
cord-002248-92pzqj35	142	30	0.1	0.1	CD
cord-002248-92pzqj35	142	31	μg	μg	NNS
cord-002248-92pzqj35	142	32	of	of	IN
cord-002248-92pzqj35	142	33	pRL	pRL	NNP
cord-002248-92pzqj35	142	34	-	-	:
cord-002248-92pzqj35	142	35	SV40	SV40	NNP
cord-002248-92pzqj35	142	36	(	(	-LRB-
cord-002248-92pzqj35	142	37	Promega	Promega	NNP
cord-002248-92pzqj35	142	38	)	)	-RRB-
cord-002248-92pzqj35	142	39	which	which	WDT
cord-002248-92pzqj35	142	40	expresses	express	VBZ
cord-002248-92pzqj35	142	41	Renilla	Renilla	NNP
cord-002248-92pzqj35	142	42	luciferase	luciferase	RB
cord-002248-92pzqj35	142	43	under	under	IN
cord-002248-92pzqj35	142	44	control	control	NN
cord-002248-92pzqj35	142	45	of	of	IN
cord-002248-92pzqj35	142	46	an	an	DT
cord-002248-92pzqj35	142	47	SV40	SV40	NNP
cord-002248-92pzqj35	142	48	promotor	promotor	NN
cord-002248-92pzqj35	142	49	.	.	.
cord-002248-92pzqj35	143	1	Renilla	Renilla	NNP
cord-002248-92pzqj35	143	2	luciferase	luciferase	NN
cord-002248-92pzqj35	143	3	activities	activity	NNS
cord-002248-92pzqj35	143	4	in	in	IN
cord-002248-92pzqj35	143	5	the	the	DT
cord-002248-92pzqj35	143	6	transfected	transfecte	VBN
cord-002248-92pzqj35	143	7	cells	cell	NNS
cord-002248-92pzqj35	143	8	were	be	VBD
cord-002248-92pzqj35	143	9	measured	measure	VBN
cord-002248-92pzqj35	143	10	by	by	IN
cord-002248-92pzqj35	143	11	using	use	VBG
cord-002248-92pzqj35	143	12	a	a	DT
cord-002248-92pzqj35	143	13	Renilla	Renilla	NNP
cord-002248-92pzqj35	143	14	luciferase	luciferase	NN
cord-002248-92pzqj35	143	15	assay	assay	NN
cord-002248-92pzqj35	143	16	system	system	NN
cord-002248-92pzqj35	143	17	(	(	-LRB-
cord-002248-92pzqj35	143	18	Promega	Promega	NNP
cord-002248-92pzqj35	143	19	)	)	-RRB-
cord-002248-92pzqj35	143	20	at	at	IN
cord-002248-92pzqj35	143	21	24h	24h	NNP
cord-002248-92pzqj35	143	22	post	post	NN
cord-002248-92pzqj35	143	23	transfection	transfection	NN
cord-002248-92pzqj35	143	24	.	.	.
cord-002248-92pzqj35	144	1	Eighteen	eighteen	CD
cord-002248-92pzqj35	144	2	-	-	HYPH
cord-002248-92pzqj35	144	3	day	day	NN
cord-002248-92pzqj35	144	4	-	-	HYPH
cord-002248-92pzqj35	144	5	old	old	JJ
cord-002248-92pzqj35	144	6	CD-1	CD-1	NNP
cord-002248-92pzqj35	144	7	mice	mouse	NNS
cord-002248-92pzqj35	144	8	were	be	VBD
cord-002248-92pzqj35	144	9	intraperitoneally	intraperitoneally	RB
cord-002248-92pzqj35	144	10	inoculated	inoculate	VBN
cord-002248-92pzqj35	144	11	with	with	IN
cord-002248-92pzqj35	144	12	10	10	CD
cord-002248-92pzqj35	144	13	4	4	CD
cord-002248-92pzqj35	144	14	PFU	pfu	NN
cord-002248-92pzqj35	144	15	of	of	IN
cord-002248-92pzqj35	144	16	MP-12	MP-12	NNP
cord-002248-92pzqj35	144	17	,	,	,
cord-002248-92pzqj35	145	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	145	2	K	K	NNP
cord-002248-92pzqj35	145	3	or	or	CC
cord-002248-92pzqj35	145	4	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	145	5	/	/	SYM
cord-002248-92pzqj35	145	6	M250	M250	NNP
cord-002248-92pzqj35	145	7	K	K	NNP
cord-002248-92pzqj35	145	8	or	or	CC
cord-002248-92pzqj35	145	9	with	with	IN
cord-002248-92pzqj35	145	10	Hank	Hank	NNP
cord-002248-92pzqj35	145	11	's	's	POS
cord-002248-92pzqj35	145	12	Balanced	Balanced	NNP
cord-002248-92pzqj35	145	13	Salt	Salt	NNP
cord-002248-92pzqj35	145	14	Solution	Solution	NNP
cord-002248-92pzqj35	145	15	(	(	-LRB-
cord-002248-92pzqj35	145	16	HBSS	HBSS	NNP
cord-002248-92pzqj35	145	17	)	)	-RRB-
cord-002248-92pzqj35	145	18	.	.	.
cord-002248-92pzqj35	146	1	The	the	DT
cord-002248-92pzqj35	146	2	animals	animal	NNS
cord-002248-92pzqj35	146	3	were	be	VBD
cord-002248-92pzqj35	146	4	observed	observe	VBN
cord-002248-92pzqj35	146	5	for	for	IN
cord-002248-92pzqj35	146	6	survival	survival	NN
cord-002248-92pzqj35	146	7	for	for	IN
cord-002248-92pzqj35	146	8	22	22	CD
cord-002248-92pzqj35	146	9	days	day	NNS
cord-002248-92pzqj35	146	10	post	post	NN
cord-002248-92pzqj35	146	11	inoculation	inoculation	NN
cord-002248-92pzqj35	146	12	.	.	.
cord-002248-92pzqj35	147	1	We	-PRON-	PRP
cord-002248-92pzqj35	147	2	previously	previously	RB
cord-002248-92pzqj35	147	3	generated	generate	VBD
cord-002248-92pzqj35	147	4	and	and	CC
cord-002248-92pzqj35	147	5	characterized	characterize	VBN
cord-002248-92pzqj35	147	6	an	an	DT
cord-002248-92pzqj35	147	7	RVFV	RVFV	NNP
cord-002248-92pzqj35	147	8	MP-12	MP-12	NNP
cord-002248-92pzqj35	147	9	strain	strain	NN
cord-002248-92pzqj35	147	10	-	-	HYPH
cord-002248-92pzqj35	147	11	derived	derive	VBN
cord-002248-92pzqj35	147	12	mutant	mutant	JJ
cord-002248-92pzqj35	147	13	virus	virus	NN
cord-002248-92pzqj35	147	14	,	,	,
cord-002248-92pzqj35	147	15	which	which	WDT
cord-002248-92pzqj35	147	16	is	be	VBZ
cord-002248-92pzqj35	147	17	deficient	deficient	JJ
cord-002248-92pzqj35	147	18	for	for	IN
cord-002248-92pzqj35	147	19	efficient	efficient	JJ
cord-002248-92pzqj35	147	20	virus	virus	NN
cord-002248-92pzqj35	147	21	genome	genome	NN
cord-002248-92pzqj35	147	22	co	co	NN
cord-002248-92pzqj35	147	23	-	-	NN
cord-002248-92pzqj35	147	24	packaging	packaging	NN
cord-002248-92pzqj35	147	25	due	due	IN
cord-002248-92pzqj35	147	26	to	to	IN
cord-002248-92pzqj35	147	27	a	a	DT
cord-002248-92pzqj35	147	28	large	large	JJ
cord-002248-92pzqj35	147	29	deletion	deletion	NN
cord-002248-92pzqj35	147	30	in	in	IN
cord-002248-92pzqj35	147	31	the	the	DT
cord-002248-92pzqj35	147	32	5	5	CD
cord-002248-92pzqj35	147	33	'	'	POS
cord-002248-92pzqj35	147	34	untranslated	untranslated	JJ
cord-002248-92pzqj35	147	35	region	region	NN
cord-002248-92pzqj35	147	36	of	of	IN
cord-002248-92pzqj35	147	37	M	M	NNP
cord-002248-92pzqj35	147	38	RNA	RNA	NNP
cord-002248-92pzqj35	147	39	segment	segment	NN
cord-002248-92pzqj35	147	40	[	[	-LRB-
cord-002248-92pzqj35	147	41	30	30	CD
cord-002248-92pzqj35	147	42	]	]	-RRB-
cord-002248-92pzqj35	147	43	.	.	.
cord-002248-92pzqj35	148	1	To	to	TO
cord-002248-92pzqj35	148	2	obtain	obtain	VB
cord-002248-92pzqj35	148	3	virus	virus	NN
cord-002248-92pzqj35	148	4	variants	variant	NNS
cord-002248-92pzqj35	148	5	,	,	,
cord-002248-92pzqj35	148	6	carrying	carry	VBG
cord-002248-92pzqj35	148	7	mutations	mutation	NNS
cord-002248-92pzqj35	148	8	that	that	WDT
cord-002248-92pzqj35	148	9	can	can	MD
cord-002248-92pzqj35	148	10	compensate	compensate	VB
cord-002248-92pzqj35	148	11	for	for	IN
cord-002248-92pzqj35	148	12	this	this	DT
cord-002248-92pzqj35	148	13	deficiency	deficiency	NN
cord-002248-92pzqj35	148	14	,	,	,
cord-002248-92pzqj35	148	15	we	-PRON-	PRP
cord-002248-92pzqj35	148	16	serially	serially	RB
cord-002248-92pzqj35	148	17	passaged	passage	VBD
cord-002248-92pzqj35	148	18	this	this	DT
cord-002248-92pzqj35	148	19	mutant	mutant	JJ
cord-002248-92pzqj35	148	20	virus	virus	NN
cord-002248-92pzqj35	148	21	in	in	IN
cord-002248-92pzqj35	148	22	type	type	NN
cord-002248-92pzqj35	149	1	I	-PRON-	PRP
cord-002248-92pzqj35	149	2	IFN	IFN	NNP
cord-002248-92pzqj35	149	3	-	-	HYPH
cord-002248-92pzqj35	149	4	incompetent	incompetent	JJ
cord-002248-92pzqj35	149	5	Vero	Vero	NNP
cord-002248-92pzqj35	149	6	E6	E6	NNP
cord-002248-92pzqj35	149	7	cells	cell	NNS
cord-002248-92pzqj35	149	8	;	;	:
cord-002248-92pzqj35	149	9	the	the	DT
cord-002248-92pzqj35	149	10	virus	virus	NN
cord-002248-92pzqj35	149	11	inoculum	inoculum	NN
cord-002248-92pzqj35	149	12	,	,	,
cord-002248-92pzqj35	149	13	used	use	VBN
cord-002248-92pzqj35	149	14	for	for	IN
cord-002248-92pzqj35	149	15	each	each	DT
cord-002248-92pzqj35	149	16	passage	passage	NN
cord-002248-92pzqj35	149	17	,	,	,
cord-002248-92pzqj35	149	18	was	be	VBD
cord-002248-92pzqj35	149	19	diluted	dilute	VBN
cord-002248-92pzqj35	149	20	10	10	CD
cord-002248-92pzqj35	149	21	times	time	NNS
cord-002248-92pzqj35	149	22	and	and	CC
cord-002248-92pzqj35	149	23	the	the	DT
cord-002248-92pzqj35	149	24	released	release	VBN
cord-002248-92pzqj35	149	25	viruses	virus	NNS
cord-002248-92pzqj35	149	26	were	be	VBD
cord-002248-92pzqj35	149	27	harvested	harvest	VBN
cord-002248-92pzqj35	149	28	at	at	IN
cord-002248-92pzqj35	149	29	4	4	CD
cord-002248-92pzqj35	149	30	days	day	NNS
cord-002248-92pzqj35	149	31	p.i	p.i	NNP
cord-002248-92pzqj35	149	32	.	.	.
cord-002248-92pzqj35	150	1	The	the	DT
cord-002248-92pzqj35	150	2	titer	titer	NN
cord-002248-92pzqj35	150	3	of	of	IN
cord-002248-92pzqj35	150	4	the	the	DT
cord-002248-92pzqj35	150	5	mutant	mutant	JJ
cord-002248-92pzqj35	150	6	virus	virus	NN
cord-002248-92pzqj35	150	7	progressively	progressively	RB
cord-002248-92pzqj35	150	8	increased	increase	VBD
cord-002248-92pzqj35	150	9	with	with	IN
cord-002248-92pzqj35	150	10	each	each	DT
cord-002248-92pzqj35	150	11	passage	passage	NN
cord-002248-92pzqj35	150	12	;	;	:
cord-002248-92pzqj35	150	13	at	at	IN
cord-002248-92pzqj35	150	14	passage	passage	NN
cord-002248-92pzqj35	150	15	18	18	CD
cord-002248-92pzqj35	150	16	,	,	,
cord-002248-92pzqj35	150	17	the	the	DT
cord-002248-92pzqj35	150	18	virus	virus	NN
cord-002248-92pzqj35	150	19	titer	titer	NN
cord-002248-92pzqj35	150	20	was	be	VBD
cord-002248-92pzqj35	150	21	2.9	2.9	CD
cord-002248-92pzqj35	150	22	x	x	SYM
cord-002248-92pzqj35	150	23	10	10	CD
cord-002248-92pzqj35	150	24	6	6	CD
cord-002248-92pzqj35	150	25	PFU	pfu	NN
cord-002248-92pzqj35	150	26	/	/	SYM
cord-002248-92pzqj35	150	27	ml	ml	NNS
cord-002248-92pzqj35	150	28	,	,	,
cord-002248-92pzqj35	150	29	which	which	WDT
cord-002248-92pzqj35	150	30	was	be	VBD
cord-002248-92pzqj35	150	31	2	2	CD
cord-002248-92pzqj35	150	32	logs	log	NNS
cord-002248-92pzqj35	150	33	higher	high	JJR
cord-002248-92pzqj35	150	34	than	than	IN
cord-002248-92pzqj35	150	35	the	the	DT
cord-002248-92pzqj35	150	36	initial	initial	JJ
cord-002248-92pzqj35	150	37	titer	titer	NN
cord-002248-92pzqj35	150	38	of	of	IN
cord-002248-92pzqj35	150	39	2.0	2.0	CD
cord-002248-92pzqj35	150	40	x	x	SYM
cord-002248-92pzqj35	150	41	10	10	CD
cord-002248-92pzqj35	150	42	4	4	CD
cord-002248-92pzqj35	150	43	PFU	pfu	NN
cord-002248-92pzqj35	150	44	/	/	SYM
cord-002248-92pzqj35	150	45	ml	ml	NNS
cord-002248-92pzqj35	150	46	prior	prior	RB
cord-002248-92pzqj35	150	47	to	to	IN
cord-002248-92pzqj35	150	48	the	the	DT
cord-002248-92pzqj35	150	49	serial	serial	JJ
cord-002248-92pzqj35	150	50	passage	passage	NN
cord-002248-92pzqj35	150	51	.	.	.
cord-002248-92pzqj35	151	1	We	-PRON-	PRP
cord-002248-92pzqj35	151	2	isolated	isolate	VBD
cord-002248-92pzqj35	151	3	34	34	CD
cord-002248-92pzqj35	151	4	plaque	plaque	NN
cord-002248-92pzqj35	151	5	-	-	HYPH
cord-002248-92pzqj35	151	6	cloned	clone	VBN
cord-002248-92pzqj35	151	7	viruses	virus	NNS
cord-002248-92pzqj35	151	8	from	from	IN
cord-002248-92pzqj35	151	9	passage	passage	NN
cord-002248-92pzqj35	151	10	level	level	NN
cord-002248-92pzqj35	151	11	18	18	CD
cord-002248-92pzqj35	151	12	,	,	,
cord-002248-92pzqj35	151	13	and	and	CC
cord-002248-92pzqj35	151	14	28	28	CD
cord-002248-92pzqj35	151	15	had	have	VBD
cord-002248-92pzqj35	151	16	a	a	DT
cord-002248-92pzqj35	151	17	large	large	JJ
cord-002248-92pzqj35	151	18	deletion	deletion	NN
cord-002248-92pzqj35	151	19	in	in	IN
cord-002248-92pzqj35	151	20	the	the	DT
cord-002248-92pzqj35	151	21	NSs	NSs	NNP
cord-002248-92pzqj35	151	22	gene	gene	NN
cord-002248-92pzqj35	151	23	in	in	IN
cord-002248-92pzqj35	151	24	the	the	DT
cord-002248-92pzqj35	151	25	S	S	NNP
cord-002248-92pzqj35	151	26	segment	segment	NN
cord-002248-92pzqj35	151	27	,	,	,
cord-002248-92pzqj35	151	28	whereas	whereas	IN
cord-002248-92pzqj35	151	29	6	6	CD
cord-002248-92pzqj35	151	30	plaque	plaque	NN
cord-002248-92pzqj35	151	31	-	-	HYPH
cord-002248-92pzqj35	151	32	cloned	clone	VBN
cord-002248-92pzqj35	151	33	viruses	virus	NNS
cord-002248-92pzqj35	151	34	retained	retain	VBD
cord-002248-92pzqj35	151	35	the	the	DT
cord-002248-92pzqj35	151	36	full	full	JJ
cord-002248-92pzqj35	151	37	-	-	HYPH
cord-002248-92pzqj35	151	38	length	length	NN
cord-002248-92pzqj35	151	39	NSs	NSs	NNP
cord-002248-92pzqj35	151	40	gene	gene	NN
cord-002248-92pzqj35	151	41	.	.	.
cord-002248-92pzqj35	152	1	We	-PRON-	PRP
cord-002248-92pzqj35	152	2	determined	determine	VBD
cord-002248-92pzqj35	152	3	the	the	DT
cord-002248-92pzqj35	152	4	full	full	JJ
cord-002248-92pzqj35	152	5	genome	genome	NN
cord-002248-92pzqj35	152	6	sequence	sequence	NN
cord-002248-92pzqj35	152	7	of	of	IN
cord-002248-92pzqj35	152	8	5	5	CD
cord-002248-92pzqj35	152	9	clones	clone	NNS
cord-002248-92pzqj35	152	10	that	that	WDT
cord-002248-92pzqj35	152	11	retained	retain	VBD
cord-002248-92pzqj35	152	12	the	the	DT
cord-002248-92pzqj35	152	13	full	full	JJ
cord-002248-92pzqj35	152	14	-	-	HYPH
cord-002248-92pzqj35	152	15	length	length	NN
cord-002248-92pzqj35	152	16	NSs	NSs	NNP
cord-002248-92pzqj35	152	17	gene	gene	NN
cord-002248-92pzqj35	152	18	and	and	CC
cord-002248-92pzqj35	152	19	found	find	VBD
cord-002248-92pzqj35	152	20	that	that	IN
cord-002248-92pzqj35	152	21	all	all	DT
cord-002248-92pzqj35	152	22	of	of	IN
cord-002248-92pzqj35	152	23	the	the	DT
cord-002248-92pzqj35	152	24	isolated	isolate	VBN
cord-002248-92pzqj35	152	25	viruses	virus	NNS
cord-002248-92pzqj35	152	26	had	have	VBD
cord-002248-92pzqj35	152	27	several	several	JJ
cord-002248-92pzqj35	152	28	mutations	mutation	NNS
cord-002248-92pzqj35	152	29	in	in	IN
cord-002248-92pzqj35	152	30	the	the	DT
cord-002248-92pzqj35	152	31	L	l	NN
cord-002248-92pzqj35	152	32	,	,	,
cord-002248-92pzqj35	152	33	M	M	NNP
cord-002248-92pzqj35	152	34	,	,	,
cord-002248-92pzqj35	152	35	and	and	CC
cord-002248-92pzqj35	152	36	S	S	NNP
cord-002248-92pzqj35	152	37	segments	segment	NNS
cord-002248-92pzqj35	152	38	.	.	.
cord-002248-92pzqj35	153	1	Table	table	NN
cord-002248-92pzqj35	153	2	1	1	CD
cord-002248-92pzqj35	153	3	shows	show	NNS
cord-002248-92pzqj35	153	4	mutations	mutation	NNS
cord-002248-92pzqj35	153	5	found	find	VBN
cord-002248-92pzqj35	153	6	in	in	IN
cord-002248-92pzqj35	153	7	the	the	DT
cord-002248-92pzqj35	153	8	NSs	NSs	NNP
cord-002248-92pzqj35	153	9	genes	gene	NNS
cord-002248-92pzqj35	153	10	of	of	IN
cord-002248-92pzqj35	153	11	5	5	CD
cord-002248-92pzqj35	153	12	plaque	plaque	NN
cord-002248-92pzqj35	153	13	-	-	HYPH
cord-002248-92pzqj35	153	14	cloned	clone	VBN
cord-002248-92pzqj35	153	15	viruses	virus	NNS
cord-002248-92pzqj35	153	16	and	and	CC
cord-002248-92pzqj35	153	17	the	the	DT
cord-002248-92pzqj35	153	18	uncloned	uncloned	JJ
cord-002248-92pzqj35	153	19	passage	passage	NN
cord-002248-92pzqj35	153	20	18	18	CD
cord-002248-92pzqj35	153	21	virus	virus	NN
cord-002248-92pzqj35	153	22	.	.	.
cord-002248-92pzqj35	154	1	All	all	DT
cord-002248-92pzqj35	154	2	five	five	CD
cord-002248-92pzqj35	154	3	plaque	plaque	NN
cord-002248-92pzqj35	154	4	-	-	HYPH
cord-002248-92pzqj35	154	5	cloned	clone	VBN
cord-002248-92pzqj35	154	6	viruses	virus	NNS
cord-002248-92pzqj35	154	7	and	and	CC
cord-002248-92pzqj35	154	8	the	the	DT
cord-002248-92pzqj35	154	9	passage	passage	NN
cord-002248-92pzqj35	154	10	18	18	CD
cord-002248-92pzqj35	154	11	virus	virus	NN
cord-002248-92pzqj35	154	12	had	have	VBD
cord-002248-92pzqj35	154	13	an	an	DT
cord-002248-92pzqj35	154	14	amino	amino	NN
cord-002248-92pzqj35	154	15	-	-	HYPH
cord-002248-92pzqj35	154	16	acid	acid	NN
cord-002248-92pzqj35	154	17	substitution	substitution	NN
cord-002248-92pzqj35	154	18	at	at	IN
cord-002248-92pzqj35	154	19	position	position	NN
cord-002248-92pzqj35	154	20	250	250	CD
cord-002248-92pzqj35	154	21	,	,	,
cord-002248-92pzqj35	154	22	including	include	VBG
cord-002248-92pzqj35	154	23	M250	M250	NNP
cord-002248-92pzqj35	154	24	K	K	NNP
cord-002248-92pzqj35	154	25	or	or	CC
cord-002248-92pzqj35	154	26	M250	M250	NNP
cord-002248-92pzqj35	154	27	T	t	NN
cord-002248-92pzqj35	154	28	mutations	mutation	NNS
cord-002248-92pzqj35	154	29	.	.	.
cord-002248-92pzqj35	155	1	Two	two	CD
cord-002248-92pzqj35	155	2	plaque	plaque	NN
cord-002248-92pzqj35	155	3	-	-	HYPH
cord-002248-92pzqj35	155	4	cloned	clone	VBN
cord-002248-92pzqj35	155	5	viruses	virus	NNS
cord-002248-92pzqj35	155	6	and	and	CC
cord-002248-92pzqj35	155	7	the	the	DT
cord-002248-92pzqj35	155	8	passage	passage	NN
cord-002248-92pzqj35	155	9	18	18	CD
cord-002248-92pzqj35	155	10	virus	virus	NN
cord-002248-92pzqj35	155	11	had	have	VBD
cord-002248-92pzqj35	155	12	a	a	DT
cord-002248-92pzqj35	155	13	D100	D100	NNP
cord-002248-92pzqj35	155	14	G	g	NN
cord-002248-92pzqj35	155	15	substitution	substitution	NN
cord-002248-92pzqj35	155	16	.	.	.
cord-002248-92pzqj35	156	1	Other	other	JJ
cord-002248-92pzqj35	156	2	mutations	mutation	NNS
cord-002248-92pzqj35	156	3	found	find	VBN
cord-002248-92pzqj35	156	4	in	in	IN
cord-002248-92pzqj35	156	5	plaque	plaque	NN
cord-002248-92pzqj35	156	6	-	-	HYPH
cord-002248-92pzqj35	156	7	cloned	clone	VBN
cord-002248-92pzqj35	156	8	viruses	virus	NNS
cord-002248-92pzqj35	156	9	were	be	VBD
cord-002248-92pzqj35	156	10	R16H	r16h	NN
cord-002248-92pzqj35	156	11	and	and	CC
cord-002248-92pzqj35	156	12	A75E.	A75E.	.
cord-002248-92pzqj35	157	1	Although	although	IN
cord-002248-92pzqj35	157	2	K202N	K202N	NNP
cord-002248-92pzqj35	157	3	mutation	mutation	NN
cord-002248-92pzqj35	157	4	was	be	VBD
cord-002248-92pzqj35	157	5	found	find	VBN
cord-002248-92pzqj35	157	6	in	in	IN
cord-002248-92pzqj35	157	7	the	the	DT
cord-002248-92pzqj35	157	8	uncloned	uncloned	JJ
cord-002248-92pzqj35	157	9	passage	passage	NN
cord-002248-92pzqj35	157	10	18	18	CD
cord-002248-92pzqj35	157	11	virus	virus	NN
cord-002248-92pzqj35	157	12	sample	sample	NN
cord-002248-92pzqj35	157	13	,	,	,
cord-002248-92pzqj35	157	14	this	this	DT
cord-002248-92pzqj35	157	15	mutation	mutation	NN
cord-002248-92pzqj35	157	16	was	be	VBD
cord-002248-92pzqj35	157	17	absent	absent	JJ
cord-002248-92pzqj35	157	18	in	in	IN
cord-002248-92pzqj35	157	19	the	the	DT
cord-002248-92pzqj35	157	20	plaque	plaque	NN
cord-002248-92pzqj35	157	21	-	-	HYPH
cord-002248-92pzqj35	157	22	cloned	clone	VBN
cord-002248-92pzqj35	157	23	viruses	virus	NNS
cord-002248-92pzqj35	157	24	.	.	.
cord-002248-92pzqj35	158	1	To	to	TO
cord-002248-92pzqj35	158	2	test	test	VB
cord-002248-92pzqj35	158	3	whether	whether	IN
cord-002248-92pzqj35	158	4	the	the	DT
cord-002248-92pzqj35	158	5	mutations	mutation	NNS
cord-002248-92pzqj35	158	6	affect	affect	VBP
cord-002248-92pzqj35	158	7	NSs	NSs	NNP
cord-002248-92pzqj35	158	8	functions	function	NNS
cord-002248-92pzqj35	158	9	,	,	,
cord-002248-92pzqj35	158	10	we	-PRON-	PRP
cord-002248-92pzqj35	158	11	generated	generate	VBD
cord-002248-92pzqj35	158	12	MP-12-based	mp-12-based	JJ
cord-002248-92pzqj35	158	13	mutant	mutant	JJ
cord-002248-92pzqj35	158	14	viruses	virus	NNS
cord-002248-92pzqj35	158	15	,	,	,
cord-002248-92pzqj35	158	16	each	each	DT
cord-002248-92pzqj35	158	17	carrying	carry	VBG
cord-002248-92pzqj35	158	18	R16H	r16h	NN
cord-002248-92pzqj35	158	19	,	,	,
cord-002248-92pzqj35	158	20	R16H+M250	R16H+M250	NNP
cord-002248-92pzqj35	158	21	K	K	NNP
cord-002248-92pzqj35	158	22	(	(	-LRB-
cord-002248-92pzqj35	158	23	NSs	NSs	NNP
cord-002248-92pzqj35	158	24	-	-	HYPH
cord-002248-92pzqj35	158	25	R16H	R16H	NNP
cord-002248-92pzqj35	158	26	/	/	SYM
cord-002248-92pzqj35	158	27	M250	M250	NNP
cord-002248-92pzqj35	158	28	K	K	NNP
cord-002248-92pzqj35	158	29	)	)	-RRB-
cord-002248-92pzqj35	158	30	,	,	,
cord-002248-92pzqj35	158	31	A75E	A75E	NNP
cord-002248-92pzqj35	158	32	,	,	,
cord-002248-92pzqj35	158	33	D100	D100	NNP
cord-002248-92pzqj35	158	34	G	G	NNP
cord-002248-92pzqj35	158	35	,	,	,
cord-002248-92pzqj35	158	36	D100G+M250	D100G+M250	NNP
cord-002248-92pzqj35	158	37	T	T	NNP
cord-002248-92pzqj35	158	38	,	,	,
cord-002248-92pzqj35	158	39	M250	M250	NNP
cord-002248-92pzqj35	158	40	K	K	NNP
cord-002248-92pzqj35	158	41	(	(	-LRB-
cord-002248-92pzqj35	158	42	NSs	NSs	NNP
cord-002248-92pzqj35	158	43	-	-	:
cord-002248-92pzqj35	158	44	M250	M250	NNP
cord-002248-92pzqj35	158	45	K	K	NNP
cord-002248-92pzqj35	158	46	)	)	-RRB-
cord-002248-92pzqj35	158	47	,	,	,
cord-002248-92pzqj35	158	48	or	or	CC
cord-002248-92pzqj35	158	49	M250	M250	NNP
cord-002248-92pzqj35	158	50	T	T	NNP
cord-002248-92pzqj35	158	51	mutations	mutation	NNS
cord-002248-92pzqj35	158	52	in	in	IN
cord-002248-92pzqj35	158	53	the	the	DT
cord-002248-92pzqj35	158	54	NSs	NSs	NNP
cord-002248-92pzqj35	158	55	,	,	,
cord-002248-92pzqj35	158	56	by	by	IN
cord-002248-92pzqj35	158	57	using	use	VBG
cord-002248-92pzqj35	158	58	a	a	DT
cord-002248-92pzqj35	158	59	reverse	reverse	JJ
cord-002248-92pzqj35	158	60	genetics	genetics	NN
cord-002248-92pzqj35	158	61	system	system	NN
cord-002248-92pzqj35	158	62	[	[	-LRB-
cord-002248-92pzqj35	158	63	24	24	CD
cord-002248-92pzqj35	158	64	]	]	-RRB-
cord-002248-92pzqj35	158	65	.	.	.
cord-002248-92pzqj35	159	1	Accumulations	accumulation	NNS
cord-002248-92pzqj35	159	2	of	of	IN
cord-002248-92pzqj35	159	3	NSs	NSs	NNP
cord-002248-92pzqj35	159	4	protein	protein	NN
cord-002248-92pzqj35	159	5	in	in	IN
cord-002248-92pzqj35	159	6	VeroE6	veroe6	NN
cord-002248-92pzqj35	159	7	cells	cell	NNS
cord-002248-92pzqj35	159	8	infected	infect	VBN
cord-002248-92pzqj35	159	9	with	with	IN
cord-002248-92pzqj35	159	10	MP-12	MP-12	NNP
cord-002248-92pzqj35	159	11	carrying	carry	VBG
cord-002248-92pzqj35	159	12	the	the	DT
cord-002248-92pzqj35	159	13	D100	D100	NNP
cord-002248-92pzqj35	159	14	G	G	NNP
cord-002248-92pzqj35	159	15	mutation	mutation	NN
cord-002248-92pzqj35	159	16	or	or	CC
cord-002248-92pzqj35	159	17	the	the	DT
cord-002248-92pzqj35	159	18	D100G+M250	D100G+M250	NNP
cord-002248-92pzqj35	159	19	T	T	NNP
cord-002248-92pzqj35	159	20	mutations	mutation	NNS
cord-002248-92pzqj35	159	21	were	be	VBD
cord-002248-92pzqj35	159	22	significantly	significantly	RB
cord-002248-92pzqj35	159	23	lower	low	JJR
cord-002248-92pzqj35	159	24	than	than	IN
cord-002248-92pzqj35	159	25	those	those	DT
cord-002248-92pzqj35	159	26	in	in	IN
cord-002248-92pzqj35	159	27	MP-12	MP-12	NNP
cord-002248-92pzqj35	159	28	infected	infected	JJ
cord-002248-92pzqj35	159	29	cells	cell	NNS
cord-002248-92pzqj35	159	30	(	(	-LRB-
cord-002248-92pzqj35	159	31	Fig	Fig	NNP
cord-002248-92pzqj35	159	32	1	1	CD
cord-002248-92pzqj35	159	33	)	)	-RRB-
cord-002248-92pzqj35	159	34	,	,	,
cord-002248-92pzqj35	159	35	indicating	indicate	VBG
cord-002248-92pzqj35	159	36	that	that	IN
cord-002248-92pzqj35	159	37	the	the	DT
cord-002248-92pzqj35	159	38	D100	D100	NNP
cord-002248-92pzqj35	159	39	G	G	NNP
cord-002248-92pzqj35	159	40	mutation	mutation	NN
cord-002248-92pzqj35	159	41	affected	affect	VBD
cord-002248-92pzqj35	159	42	efficient	efficient	JJ
cord-002248-92pzqj35	159	43	NSs	NSs	NNP
cord-002248-92pzqj35	159	44	accumulation	accumulation	NN
cord-002248-92pzqj35	159	45	.	.	.
cord-002248-92pzqj35	160	1	Due	due	IN
cord-002248-92pzqj35	160	2	to	to	IN
cord-002248-92pzqj35	160	3	the	the	DT
cord-002248-92pzqj35	160	4	poor	poor	JJ
cord-002248-92pzqj35	160	5	accumulation	accumulation	NN
cord-002248-92pzqj35	160	6	of	of	IN
cord-002248-92pzqj35	160	7	NSs	NSs	NNP
cord-002248-92pzqj35	160	8	,	,	,
cord-002248-92pzqj35	160	9	we	-PRON-	PRP
cord-002248-92pzqj35	160	10	excluded	exclude	VBD
cord-002248-92pzqj35	160	11	the	the	DT
cord-002248-92pzqj35	160	12	MP-12	MP-12	NNP
cord-002248-92pzqj35	160	13	mutant	mutant	JJ
cord-002248-92pzqj35	160	14	carrying	carry	VBG
cord-002248-92pzqj35	160	15	the	the	DT
cord-002248-92pzqj35	160	16	D100	D100	NNP
cord-002248-92pzqj35	160	17	G	G	NNP
cord-002248-92pzqj35	160	18	mutation	mutation	NN
cord-002248-92pzqj35	160	19	and	and	CC
cord-002248-92pzqj35	160	20	that	that	IN
cord-002248-92pzqj35	160	21	carrying	carry	VBG
cord-002248-92pzqj35	160	22	the	the	DT
cord-002248-92pzqj35	160	23	D100G+M250	D100G+M250	NNP
cord-002248-92pzqj35	160	24	T	T	NNP
cord-002248-92pzqj35	160	25	mutation	mutation	NN
cord-002248-92pzqj35	160	26	from	from	IN
cord-002248-92pzqj35	160	27	subsequent	subsequent	JJ
cord-002248-92pzqj35	160	28	analysis	analysis	NN
cord-002248-92pzqj35	160	29	.	.	.
cord-002248-92pzqj35	161	1	In	in	IN
cord-002248-92pzqj35	161	2	cells	cell	NNS
cord-002248-92pzqj35	161	3	infected	infect	VBN
cord-002248-92pzqj35	161	4	with	with	IN
cord-002248-92pzqj35	161	5	the	the	DT
cord-002248-92pzqj35	161	6	other	other	JJ
cord-002248-92pzqj35	161	7	mutants	mutant	NNS
cord-002248-92pzqj35	161	8	,	,	,
cord-002248-92pzqj35	161	9	levels	level	NNS
cord-002248-92pzqj35	161	10	of	of	IN
cord-002248-92pzqj35	161	11	NSs	NSs	NNP
cord-002248-92pzqj35	161	12	protein	protein	NN
cord-002248-92pzqj35	161	13	accumulation	accumulation	NN
cord-002248-92pzqj35	161	14	were	be	VBD
cord-002248-92pzqj35	161	15	similar	similar	JJ
cord-002248-92pzqj35	161	16	to	to	IN
cord-002248-92pzqj35	161	17	that	that	DT
cord-002248-92pzqj35	161	18	in	in	IN
cord-002248-92pzqj35	161	19	MP-12	MP-12	NNP
cord-002248-92pzqj35	161	20	infected	infected	JJ
cord-002248-92pzqj35	161	21	cells	cell	NNS
cord-002248-92pzqj35	161	22	.	.	.
cord-002248-92pzqj35	162	1	In	in	IN
cord-002248-92pzqj35	162	2	this	this	DT
cord-002248-92pzqj35	162	3	study	study	NN
cord-002248-92pzqj35	162	4	,	,	,
cord-002248-92pzqj35	162	5	we	-PRON-	PRP
cord-002248-92pzqj35	162	6	refer	refer	VBP
cord-002248-92pzqj35	162	7	to	to	IN
cord-002248-92pzqj35	162	8	MP-12	MP-12	NNP
cord-002248-92pzqj35	162	9	NSs	NSs	NNP
cord-002248-92pzqj35	162	10	as	as	IN
cord-002248-92pzqj35	162	11	wild	wild	JJ
cord-002248-92pzqj35	162	12	type	type	NN
cord-002248-92pzqj35	162	13	NSs	nss	NN
cord-002248-92pzqj35	162	14	(	(	-LRB-
cord-002248-92pzqj35	162	15	wt	wt	NN
cord-002248-92pzqj35	162	16	NSs	NSs	NNP
cord-002248-92pzqj35	162	17	)	)	-RRB-
cord-002248-92pzqj35	162	18	.	.	.
cord-002248-92pzqj35	163	1	To	to	TO
cord-002248-92pzqj35	163	2	evaluate	evaluate	VB
cord-002248-92pzqj35	163	3	host	host	NN
cord-002248-92pzqj35	163	4	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	163	5	shut	shut	VB
cord-002248-92pzqj35	163	6	-	-	HYPH
cord-002248-92pzqj35	163	7	off	off	RP
cord-002248-92pzqj35	163	8	activities	activity	NNS
cord-002248-92pzqj35	163	9	of	of	IN
cord-002248-92pzqj35	163	10	these	these	DT
cord-002248-92pzqj35	163	11	NSs	NSs	NNP
cord-002248-92pzqj35	163	12	mutants	mutant	NNS
cord-002248-92pzqj35	163	13	,	,	,
cord-002248-92pzqj35	163	14	levels	level	NNS
cord-002248-92pzqj35	163	15	of	of	IN
cord-002248-92pzqj35	163	16	RNA	RNA	NNP
cord-002248-92pzqj35	163	17	synthesis	synthesis	NN
cord-002248-92pzqj35	163	18	in	in	IN
cord-002248-92pzqj35	163	19	virus	virus	NN
cord-002248-92pzqj35	163	20	-	-	HYPH
cord-002248-92pzqj35	163	21	infected	infect	VBN
cord-002248-92pzqj35	163	22	VeroE6	veroe6	NN
cord-002248-92pzqj35	163	23	cells	cell	NNS
cord-002248-92pzqj35	163	24	were	be	VBD
cord-002248-92pzqj35	163	25	measured	measure	VBN
cord-002248-92pzqj35	163	26	by	by	IN
cord-002248-92pzqj35	163	27	labeling	label	VBG
cord-002248-92pzqj35	163	28	with	with	IN
cord-002248-92pzqj35	163	29	5EU	5eu	CD
cord-002248-92pzqj35	163	30	from	from	IN
cord-002248-92pzqj35	163	31	16	16	CD
cord-002248-92pzqj35	163	32	h	h	NN
cord-002248-92pzqj35	163	33	to	to	IN
cord-002248-92pzqj35	163	34	17	17	CD
cord-002248-92pzqj35	163	35	h	h	NN
cord-002248-92pzqj35	163	36	p.i	p.i	NNP
cord-002248-92pzqj35	163	37	.	.	.
cord-002248-92pzqj35	163	38	Mock	Mock	NNP
cord-002248-92pzqj35	163	39	-	-	HYPH
cord-002248-92pzqj35	163	40	infected	infect	VBN
cord-002248-92pzqj35	163	41	cells	cell	NNS
cord-002248-92pzqj35	163	42	alone	alone	RB
cord-002248-92pzqj35	163	43	,	,	,
cord-002248-92pzqj35	163	44	as	as	RB
cord-002248-92pzqj35	163	45	well	well	RB
cord-002248-92pzqj35	163	46	as	as	IN
cord-002248-92pzqj35	163	47	those	those	DT
cord-002248-92pzqj35	163	48	treated	treat	VBN
cord-002248-92pzqj35	163	49	with	with	IN
cord-002248-92pzqj35	163	50	ActD	ActD	NNP
cord-002248-92pzqj35	163	51	,	,	,
cord-002248-92pzqj35	163	52	and	and	CC
cord-002248-92pzqj35	163	53	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	163	54	cells	cell	NNS
cord-002248-92pzqj35	163	55	and	and	CC
cord-002248-92pzqj35	163	56	cells	cell	NNS
cord-002248-92pzqj35	163	57	infected	infect	VBN
cord-002248-92pzqj35	163	58	with	with	IN
cord-002248-92pzqj35	163	59	MP-12ΔNSs	MP-12ΔNSs	NNP
cord-002248-92pzqj35	163	60	,	,	,
cord-002248-92pzqj35	163	61	which	which	WDT
cord-002248-92pzqj35	163	62	lacks	lack	VBZ
cord-002248-92pzqj35	163	63	the	the	DT
cord-002248-92pzqj35	163	64	NSs	NSs	NNP
cord-002248-92pzqj35	163	65	gene	gene	NN
cord-002248-92pzqj35	163	66	[	[	-LRB-
cord-002248-92pzqj35	163	67	24	24	CD
cord-002248-92pzqj35	163	68	]	]	-RRB-
cord-002248-92pzqj35	163	69	,	,	,
cord-002248-92pzqj35	163	70	served	serve	VBD
cord-002248-92pzqj35	163	71	as	as	IN
cord-002248-92pzqj35	163	72	controls	control	NNS
cord-002248-92pzqj35	163	73	.	.	.
cord-002248-92pzqj35	164	1	5EU	5eu	CD
cord-002248-92pzqj35	164	2	-	-	HYPH
cord-002248-92pzqj35	164	3	labeled	label	VBN
cord-002248-92pzqj35	164	4	RNA	RNA	NNP
cord-002248-92pzqj35	164	5	,	,	,
cord-002248-92pzqj35	164	6	which	which	WDT
cord-002248-92pzqj35	164	7	was	be	VBD
cord-002248-92pzqj35	164	8	detected	detect	VBN
cord-002248-92pzqj35	164	9	as	as	IN
cord-002248-92pzqj35	164	10	a	a	DT
cord-002248-92pzqj35	164	11	fluorescence	fluorescence	NN
cord-002248-92pzqj35	164	12	signal	signal	NN
cord-002248-92pzqj35	164	13	,	,	,
cord-002248-92pzqj35	164	14	was	be	VBD
cord-002248-92pzqj35	164	15	mainly	mainly	RB
cord-002248-92pzqj35	164	16	observed	observe	VBN
cord-002248-92pzqj35	164	17	in	in	IN
cord-002248-92pzqj35	164	18	the	the	DT
cord-002248-92pzqj35	164	19	nucleus	nucleus	NN
cord-002248-92pzqj35	164	20	but	but	CC
cord-002248-92pzqj35	164	21	not	not	RB
cord-002248-92pzqj35	164	22	in	in	IN
cord-002248-92pzqj35	164	23	the	the	DT
cord-002248-92pzqj35	164	24	cytoplasm	cytoplasm	NN
cord-002248-92pzqj35	164	25	,	,	,
cord-002248-92pzqj35	164	26	indicating	indicate	VBG
cord-002248-92pzqj35	164	27	that	that	IN
cord-002248-92pzqj35	164	28	viral	viral	JJ
cord-002248-92pzqj35	164	29	RNA	RNA	NNP
cord-002248-92pzqj35	164	30	synthesis	synthesis	NN
cord-002248-92pzqj35	164	31	,	,	,
cord-002248-92pzqj35	164	32	which	which	WDT
cord-002248-92pzqj35	164	33	occurs	occur	VBZ
cord-002248-92pzqj35	164	34	exclusively	exclusively	RB
cord-002248-92pzqj35	164	35	in	in	IN
cord-002248-92pzqj35	164	36	the	the	DT
cord-002248-92pzqj35	164	37	cytoplasm	cytoplasm	NN
cord-002248-92pzqj35	164	38	,	,	,
cord-002248-92pzqj35	164	39	was	be	VBD
cord-002248-92pzqj35	164	40	not	not	RB
cord-002248-92pzqj35	164	41	very	very	RB
cord-002248-92pzqj35	164	42	active	active	JJ
cord-002248-92pzqj35	164	43	at	at	IN
cord-002248-92pzqj35	164	44	16h	16h	CD
cord-002248-92pzqj35	164	45	post	post	NN
cord-002248-92pzqj35	164	46	infection	infection	NN
cord-002248-92pzqj35	164	47	.	.	.
cord-002248-92pzqj35	165	1	As	as	IN
cord-002248-92pzqj35	165	2	shown	show	VBN
cord-002248-92pzqj35	165	3	in	in	IN
cord-002248-92pzqj35	165	4	Fig	Fig	NNP
cord-002248-92pzqj35	165	5	2A	2a	CD
cord-002248-92pzqj35	165	6	,	,	,
cord-002248-92pzqj35	165	7	strong	strong	JJ
cord-002248-92pzqj35	165	8	signals	signal	NNS
cord-002248-92pzqj35	165	9	of	of	IN
cord-002248-92pzqj35	165	10	fluorescent	fluorescent	NN
cord-002248-92pzqj35	165	11	-	-	HYPH
cord-002248-92pzqj35	165	12	labeled	label	VBN
cord-002248-92pzqj35	165	13	RNA	RNA	NNP
cord-002248-92pzqj35	165	14	were	be	VBD
cord-002248-92pzqj35	165	15	observed	observe	VBN
cord-002248-92pzqj35	165	16	in	in	IN
cord-002248-92pzqj35	165	17	the	the	DT
cord-002248-92pzqj35	165	18	nucleus	nucleus	NN
cord-002248-92pzqj35	165	19	of	of	IN
cord-002248-92pzqj35	165	20	mock	mock	JJ
cord-002248-92pzqj35	165	21	-	-	HYPH
cord-002248-92pzqj35	165	22	infected	infect	VBN
cord-002248-92pzqj35	165	23	cells	cell	NNS
cord-002248-92pzqj35	165	24	and	and	CC
cord-002248-92pzqj35	165	25	MP-12ΔNSsinfected	mp-12δnssinfected	JJ
cord-002248-92pzqj35	165	26	cells	cell	NNS
cord-002248-92pzqj35	165	27	,	,	,
cord-002248-92pzqj35	165	28	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	165	29	active	active	JJ
cord-002248-92pzqj35	165	30	host	host	NN
cord-002248-92pzqj35	165	31	RNA	RNA	NNP
cord-002248-92pzqj35	165	32	synthesis	synthesis	NN
cord-002248-92pzqj35	165	33	.	.	.
cord-002248-92pzqj35	166	1	In	in	IN
cord-002248-92pzqj35	166	2	contrast	contrast	NN
cord-002248-92pzqj35	166	3	,	,	,
cord-002248-92pzqj35	166	4	ActD	ActD	NNP
cord-002248-92pzqj35	166	5	-	-	HYPH
cord-002248-92pzqj35	166	6	treated	treat	VBN
cord-002248-92pzqj35	166	7	cells	cell	NNS
cord-002248-92pzqj35	166	8	showed	show	VBD
cord-002248-92pzqj35	166	9	very	very	RB
cord-002248-92pzqj35	166	10	weak	weak	JJ
cord-002248-92pzqj35	166	11	fluorescent	fluorescent	NN
cord-002248-92pzqj35	166	12	signals	signal	NNS
cord-002248-92pzqj35	166	13	,	,	,
cord-002248-92pzqj35	166	14	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	166	15	ActD	ActD	NNP
cord-002248-92pzqj35	166	16	-	-	HYPH
cord-002248-92pzqj35	166	17	mediated	mediate	VBN
cord-002248-92pzqj35	166	18	host	host	NN
cord-002248-92pzqj35	166	19	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	166	20	shut	shut	NN
cord-002248-92pzqj35	166	21	-	-	HYPH
cord-002248-92pzqj35	166	22	off	off	NN
cord-002248-92pzqj35	166	23	.	.	.
cord-002248-92pzqj35	167	1	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	167	2	cells	cell	NNS
cord-002248-92pzqj35	167	3	showed	show	VBD
cord-002248-92pzqj35	167	4	weaker	weak	JJR
cord-002248-92pzqj35	167	5	fluorescent	fluorescent	JJ
cord-002248-92pzqj35	167	6	signals	signal	NNS
cord-002248-92pzqj35	167	7	in	in	IN
cord-002248-92pzqj35	167	8	the	the	DT
cord-002248-92pzqj35	167	9	nucleus	nucleus	NN
cord-002248-92pzqj35	167	10	,	,	,
cord-002248-92pzqj35	167	11	compared	compare	VBN
cord-002248-92pzqj35	167	12	with	with	IN
cord-002248-92pzqj35	167	13	those	those	DT
cord-002248-92pzqj35	167	14	in	in	IN
cord-002248-92pzqj35	167	15	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	167	16	-	-	HYPH
cord-002248-92pzqj35	167	17	infected	infect	VBN
cord-002248-92pzqj35	167	18	cells	cell	NNS
cord-002248-92pzqj35	167	19	,	,	,
cord-002248-92pzqj35	167	20	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	167	21	an	an	DT
cord-002248-92pzqj35	167	22	inhibition	inhibition	NN
cord-002248-92pzqj35	167	23	of	of	IN
cord-002248-92pzqj35	167	24	host	host	NN
cord-002248-92pzqj35	167	25	transcription	transcription	NN
cord-002248-92pzqj35	167	26	by	by	IN
cord-002248-92pzqj35	167	27	NSs	NSs	NNP
cord-002248-92pzqj35	167	28	.	.	.
cord-002248-92pzqj35	168	1	Fluorescent	fluorescent	JJ
cord-002248-92pzqj35	168	2	intensity	intensity	NN
cord-002248-92pzqj35	168	3	observed	observe	VBN
cord-002248-92pzqj35	168	4	in	in	IN
cord-002248-92pzqj35	168	5	cells	cell	NNS
cord-002248-92pzqj35	168	6	infected	infect	VBN
cord-002248-92pzqj35	168	7	with	with	IN
cord-002248-92pzqj35	168	8	virus	virus	NN
cord-002248-92pzqj35	168	9	carrying	carry	VBG
cord-002248-92pzqj35	168	10	mutation	mutation	NN
cord-002248-92pzqj35	168	11	M250	M250	NNP
cord-002248-92pzqj35	168	12	T	T	NNP
cord-002248-92pzqj35	168	13	,	,	,
cord-002248-92pzqj35	168	14	R16H	r16h	NN
cord-002248-92pzqj35	168	15	or	or	CC
cord-002248-92pzqj35	168	16	A75E	A75E	NNP
cord-002248-92pzqj35	168	17	in	in	IN
cord-002248-92pzqj35	168	18	NSs	NSs	NNP
cord-002248-92pzqj35	168	19	was	be	VBD
cord-002248-92pzqj35	168	20	similar	similar	JJ
cord-002248-92pzqj35	168	21	to	to	IN
cord-002248-92pzqj35	168	22	that	that	DT
cord-002248-92pzqj35	168	23	in	in	IN
cord-002248-92pzqj35	168	24	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	168	25	cells	cell	NNS
cord-002248-92pzqj35	168	26	,	,	,
cord-002248-92pzqj35	168	27	suggesting	suggest	VBG
cord-002248-92pzqj35	168	28	that	that	IN
cord-002248-92pzqj35	168	29	host	host	NN
cord-002248-92pzqj35	168	30	transcription	transcription	NN
cord-002248-92pzqj35	168	31	was	be	VBD
cord-002248-92pzqj35	168	32	still	still	RB
cord-002248-92pzqj35	168	33	inhibited	inhibit	VBN
cord-002248-92pzqj35	168	34	by	by	IN
cord-002248-92pzqj35	168	35	these	these	DT
cord-002248-92pzqj35	168	36	NSs	NSs	NNP
cord-002248-92pzqj35	168	37	mutants	mutant	NNS
cord-002248-92pzqj35	168	38	.	.	.
cord-002248-92pzqj35	169	1	In	in	IN
cord-002248-92pzqj35	169	2	contrast	contrast	NN
cord-002248-92pzqj35	169	3	,	,	,
cord-002248-92pzqj35	169	4	cells	cell	NNS
cord-002248-92pzqj35	169	5	infected	infect	VBN
cord-002248-92pzqj35	169	6	with	with	IN
cord-002248-92pzqj35	169	7	MP-12	MP-12	NNP
cord-002248-92pzqj35	169	8	carrying	carry	VBG
cord-002248-92pzqj35	169	9	NSs-	nss-	NN
cord-002248-92pzqj35	170	1	R16H/	R16H/	NNP
cord-002248-92pzqj35	171	1	We	-PRON-	PRP
cord-002248-92pzqj35	171	2	next	next	RB
cord-002248-92pzqj35	171	3	used	use	VBD
cord-002248-92pzqj35	171	4	flow	flow	NN
cord-002248-92pzqj35	171	5	cytometry	cytometry	NN
cord-002248-92pzqj35	171	6	analysis	analysis	NN
cord-002248-92pzqj35	171	7	to	to	TO
cord-002248-92pzqj35	171	8	quantitatively	quantitatively	RB
cord-002248-92pzqj35	171	9	measure	measure	VB
cord-002248-92pzqj35	171	10	the	the	DT
cord-002248-92pzqj35	171	11	levels	level	NNS
cord-002248-92pzqj35	171	12	of	of	IN
cord-002248-92pzqj35	171	13	5EU	5eu	CD
cord-002248-92pzqj35	171	14	-	-	HYPH
cord-002248-92pzqj35	171	15	labeled	label	VBN
cord-002248-92pzqj35	171	16	RNAs	rna	NNS
cord-002248-92pzqj35	171	17	in	in	IN
cord-002248-92pzqj35	171	18	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	171	19	-	-	HYPH
cord-002248-92pzqj35	171	20	infected	infect	VBN
cord-002248-92pzqj35	171	21	cells	cell	NNS
cord-002248-92pzqj35	171	22	and	and	CC
cord-002248-92pzqj35	171	23	in	in	IN
cord-002248-92pzqj35	171	24	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	171	25	/	/	SYM
cord-002248-92pzqj35	171	26	M250K	m250k	NN
cord-002248-92pzqj35	171	27	-	-	HYPH
cord-002248-92pzqj35	171	28	infected	infect	VBN
cord-002248-92pzqj35	171	29	cells	cell	NNS
cord-002248-92pzqj35	171	30	.	.	.
cord-002248-92pzqj35	172	1	We	-PRON-	PRP
cord-002248-92pzqj35	172	2	used	use	VBD
cord-002248-92pzqj35	172	3	the	the	DT
cord-002248-92pzqj35	172	4	same	same	JJ
cord-002248-92pzqj35	172	5	controls	control	NNS
cord-002248-92pzqj35	172	6	as	as	IN
cord-002248-92pzqj35	172	7	described	describe	VBN
cord-002248-92pzqj35	172	8	above	above	RB
cord-002248-92pzqj35	172	9	.	.	.
cord-002248-92pzqj35	173	1	Fig	Fig	NNP
cord-002248-92pzqj35	173	2	2B	2b	CD
cord-002248-92pzqj35	173	3	shows	show	VBZ
cord-002248-92pzqj35	173	4	the	the	DT
cord-002248-92pzqj35	173	5	results	result	NNS
cord-002248-92pzqj35	173	6	using	use	VBG
cord-002248-92pzqj35	173	7	density	density	NN
cord-002248-92pzqj35	173	8	plots	plot	NNS
cord-002248-92pzqj35	173	9	,	,	,
cord-002248-92pzqj35	173	10	wherein	wherein	WRB
cord-002248-92pzqj35	173	11	5EU	5eu	CD
cord-002248-92pzqj35	173	12	incorporation	incorporation	NN
cord-002248-92pzqj35	173	13	and	and	CC
cord-002248-92pzqj35	173	14	N	n	CD
cord-002248-92pzqj35	173	15	protein	protein	NN
cord-002248-92pzqj35	173	16	levels	level	NNS
cord-002248-92pzqj35	173	17	are	be	VBP
cord-002248-92pzqj35	173	18	shown	show	VBN
cord-002248-92pzqj35	173	19	on	on	IN
cord-002248-92pzqj35	173	20	the	the	DT
cord-002248-92pzqj35	173	21	X	x	NN
cord-002248-92pzqj35	173	22	and	and	CC
cord-002248-92pzqj35	173	23	Y	Y	NNP
cord-002248-92pzqj35	173	24	axes	axis	NNS
cord-002248-92pzqj35	173	25	,	,	,
cord-002248-92pzqj35	173	26	respectively	respectively	RB
cord-002248-92pzqj35	173	27	.	.	.
cord-002248-92pzqj35	174	1	In	in	IN
cord-002248-92pzqj35	174	2	mockinfected	mockinfected	JJ
cord-002248-92pzqj35	174	3	and	and	CC
cord-002248-92pzqj35	174	4	ActD	ActD	NNP
cord-002248-92pzqj35	174	5	-	-	HYPH
cord-002248-92pzqj35	174	6	treated	treat	VBN
cord-002248-92pzqj35	174	7	samples	sample	NNS
cord-002248-92pzqj35	174	8	,	,	,
cord-002248-92pzqj35	174	9	most	most	JJS
cord-002248-92pzqj35	174	10	of	of	IN
cord-002248-92pzqj35	174	11	the	the	DT
cord-002248-92pzqj35	174	12	cells	cell	NNS
cord-002248-92pzqj35	174	13	were	be	VBD
cord-002248-92pzqj35	174	14	found	find	VBN
cord-002248-92pzqj35	174	15	in	in	IN
cord-002248-92pzqj35	174	16	quadrant	quadrant	JJ
cord-002248-92pzqj35	174	17	3	3	CD
cord-002248-92pzqj35	174	18	(	(	-LRB-
cord-002248-92pzqj35	174	19	Q3	Q3	NNP
cord-002248-92pzqj35	174	20	)	)	-RRB-
cord-002248-92pzqj35	174	21	and	and	CC
cord-002248-92pzqj35	174	22	Q4	Q4	NNP
cord-002248-92pzqj35	174	23	,	,	,
cord-002248-92pzqj35	174	24	respectively	respectively	RB
cord-002248-92pzqj35	174	25	,	,	,
cord-002248-92pzqj35	174	26	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	174	27	active	active	JJ
cord-002248-92pzqj35	174	28	host	host	NN
cord-002248-92pzqj35	174	29	transcription	transcription	NN
cord-002248-92pzqj35	174	30	in	in	IN
cord-002248-92pzqj35	174	31	the	the	DT
cord-002248-92pzqj35	174	32	former	former	JJ
cord-002248-92pzqj35	174	33	,	,	,
cord-002248-92pzqj35	174	34	but	but	CC
cord-002248-92pzqj35	174	35	not	not	RB
cord-002248-92pzqj35	174	36	in	in	IN
cord-002248-92pzqj35	174	37	the	the	DT
cord-002248-92pzqj35	174	38	latter	latter	JJ
cord-002248-92pzqj35	175	1	(	(	-LRB-
cord-002248-92pzqj35	175	2	Fig	Fig	NNP
cord-002248-92pzqj35	175	3	 	 	_SP
cord-002248-92pzqj35	175	4	2B	2B	NNP
cord-002248-92pzqj35	175	5	-	-	HYPH
cord-002248-92pzqj35	175	6	a	a	NN
cord-002248-92pzqj35	175	7	and	and	CC
cord-002248-92pzqj35	175	8	2B	2b	CD
cord-002248-92pzqj35	175	9	-	-	HYPH
cord-002248-92pzqj35	175	10	b	b	NN
cord-002248-92pzqj35	175	11	)	)	-RRB-
cord-002248-92pzqj35	175	12	.	.	.
cord-002248-92pzqj35	176	1	In	in	IN
cord-002248-92pzqj35	176	2	all	all	DT
cord-002248-92pzqj35	176	3	infected	infected	JJ
cord-002248-92pzqj35	176	4	samples	sample	NNS
cord-002248-92pzqj35	176	5	,	,	,
cord-002248-92pzqj35	176	6	86.8	86.8	CD
cord-002248-92pzqj35	176	7	-	-	HYPH
cord-002248-92pzqj35	176	8	93.4	93.4	CD
cord-002248-92pzqj35	176	9	%	%	NN
cord-002248-92pzqj35	176	10	of	of	IN
cord-002248-92pzqj35	176	11	cells	cell	NNS
cord-002248-92pzqj35	176	12	were	be	VBD
cord-002248-92pzqj35	176	13	RVFV	RVFV	NNP
cord-002248-92pzqj35	176	14	N	N	NNP
cord-002248-92pzqj35	176	15	protein	protein	NN
cord-002248-92pzqj35	176	16	positive	positive	JJ
cord-002248-92pzqj35	176	17	(	(	-LRB-
cord-002248-92pzqj35	176	18	Q1+Q2	Q1+Q2	NNP
cord-002248-92pzqj35	176	19	)	)	-RRB-
cord-002248-92pzqj35	176	20	,	,	,
cord-002248-92pzqj35	176	21	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	176	22	that	that	IN
cord-002248-92pzqj35	176	23	most	most	JJS
cord-002248-92pzqj35	176	24	of	of	IN
cord-002248-92pzqj35	176	25	the	the	DT
cord-002248-92pzqj35	176	26	cells	cell	NNS
cord-002248-92pzqj35	176	27	were	be	VBD
cord-002248-92pzqj35	176	28	infected	infect	VBN
cord-002248-92pzqj35	176	29	.	.	.
cord-002248-92pzqj35	177	1	The	the	DT
cord-002248-92pzqj35	177	2	level	level	NN
cord-002248-92pzqj35	177	3	of	of	IN
cord-002248-92pzqj35	177	4	5EU	5eu	CD
cord-002248-92pzqj35	177	5	-	-	HYPH
cord-002248-92pzqj35	177	6	labeled	label	VBN
cord-002248-92pzqj35	177	7	RNA	RNA	NNP
cord-002248-92pzqj35	177	8	in	in	IN
cord-002248-92pzqj35	177	9	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	177	10	-	-	HYPH
cord-002248-92pzqj35	177	11	infected	infect	VBN
cord-002248-92pzqj35	177	12	cells	cell	NNS
cord-002248-92pzqj35	177	13	was	be	VBD
cord-002248-92pzqj35	177	14	similar	similar	JJ
cord-002248-92pzqj35	177	15	to	to	IN
cord-002248-92pzqj35	177	16	that	that	DT
cord-002248-92pzqj35	177	17	in	in	IN
cord-002248-92pzqj35	177	18	mock	mock	JJ
cord-002248-92pzqj35	177	19	-	-	HYPH
cord-002248-92pzqj35	177	20	infected	infect	VBN
cord-002248-92pzqj35	177	21	cells	cell	NNS
cord-002248-92pzqj35	177	22	,	,	,
cord-002248-92pzqj35	177	23	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	177	24	similar	similar	JJ
cord-002248-92pzqj35	177	25	RNA	RNA	NNP
cord-002248-92pzqj35	177	26	synthesis	synthesis	NN
cord-002248-92pzqj35	177	27	activity	activity	NN
cord-002248-92pzqj35	177	28	in	in	IN
cord-002248-92pzqj35	177	29	these	these	DT
cord-002248-92pzqj35	177	30	two	two	CD
cord-002248-92pzqj35	177	31	samples	sample	NNS
cord-002248-92pzqj35	177	32	(	(	-LRB-
cord-002248-92pzqj35	177	33	Fig	Fig	NNP
cord-002248-92pzqj35	177	34	2B	2B	NNP
cord-002248-92pzqj35	177	35	-	-	:
cord-002248-92pzqj35	177	36	a	a	NN
cord-002248-92pzqj35	177	37	and	and	CC
cord-002248-92pzqj35	177	38	2B	2b	CD
cord-002248-92pzqj35	177	39	-	-	HYPH
cord-002248-92pzqj35	177	40	f	f	NN
cord-002248-92pzqj35	177	41	)	)	-RRB-
cord-002248-92pzqj35	177	42	.	.	.
cord-002248-92pzqj35	178	1	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	178	2	cells	cell	NNS
cord-002248-92pzqj35	178	3	showed	show	VBD
cord-002248-92pzqj35	178	4	lower	low	JJR
cord-002248-92pzqj35	178	5	levels	level	NNS
cord-002248-92pzqj35	178	6	of	of	IN
cord-002248-92pzqj35	178	7	5EU	5eu	CD
cord-002248-92pzqj35	178	8	-	-	HYPH
cord-002248-92pzqj35	178	9	labeled	label	VBN
cord-002248-92pzqj35	178	10	RNA	rna	NN
cord-002248-92pzqj35	178	11	compared	compare	VBN
cord-002248-92pzqj35	178	12	with	with	IN
cord-002248-92pzqj35	178	13	those	those	DT
cord-002248-92pzqj35	178	14	in	in	IN
cord-002248-92pzqj35	178	15	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	178	16	infected	infected	JJ
cord-002248-92pzqj35	178	17	cells	cell	NNS
cord-002248-92pzqj35	178	18	,	,	,
cord-002248-92pzqj35	178	19	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	178	20	its	-PRON-	PRP$
cord-002248-92pzqj35	178	21	lower	low	JJR
cord-002248-92pzqj35	178	22	RNA	rna	NN
cord-002248-92pzqj35	178	23	transcription	transcription	NN
cord-002248-92pzqj35	178	24	activity	activity	NN
cord-002248-92pzqj35	178	25	(	(	-LRB-
cord-002248-92pzqj35	178	26	Fig	Fig	NNP
cord-002248-92pzqj35	178	27	2B	2B	NNP
cord-002248-92pzqj35	178	28	-	-	HYPH
cord-002248-92pzqj35	178	29	c	c	NN
cord-002248-92pzqj35	178	30	and	and	CC
cord-002248-92pzqj35	178	31	2B	2b	CD
cord-002248-92pzqj35	178	32	-	-	HYPH
cord-002248-92pzqj35	178	33	f	f	NNP
cord-002248-92pzqj35	178	34	)	)	-RRB-
cord-002248-92pzqj35	178	35	.	.	.
cord-002248-92pzqj35	179	1	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	179	2	/	/	,
cord-002248-92pzqj35	179	3	M250Kinfected	M250Kinfected	NNP
cord-002248-92pzqj35	179	4	and	and	CC
cord-002248-92pzqj35	180	1	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	180	2	-	-	HYPH
cord-002248-92pzqj35	180	3	infected	infect	VBN
cord-002248-92pzqj35	180	4	cells	cell	NNS
cord-002248-92pzqj35	180	5	showed	show	VBD
cord-002248-92pzqj35	180	6	similar	similar	JJ
cord-002248-92pzqj35	180	7	density	density	NN
cord-002248-92pzqj35	180	8	plot	plot	NN
cord-002248-92pzqj35	180	9	patterns	pattern	NNS
cord-002248-92pzqj35	180	10	,	,	,
cord-002248-92pzqj35	180	11	suggesting	suggest	VBG
cord-002248-92pzqj35	180	12	to	to	IN
cord-002248-92pzqj35	180	13	us	-PRON-	PRP
cord-002248-92pzqj35	180	14	that	that	DT
cord-002248-92pzqj35	180	15	host	host	NN
cord-002248-92pzqj35	180	16	transcription	transcription	NN
cord-002248-92pzqj35	180	17	inhibition	inhibition	NN
cord-002248-92pzqj35	180	18	did	do	VBD
cord-002248-92pzqj35	180	19	not	not	RB
cord-002248-92pzqj35	180	20	occur	occur	VB
cord-002248-92pzqj35	180	21	in	in	IN
cord-002248-92pzqj35	180	22	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	180	23	/	/	SYM
cord-002248-92pzqj35	180	24	M250K	m250k	NN
cord-002248-92pzqj35	180	25	-	-	HYPH
cord-002248-92pzqj35	180	26	infected	infect	VBN
cord-002248-92pzqj35	180	27	cells	cell	NNS
cord-002248-92pzqj35	180	28	(	(	-LRB-
cord-002248-92pzqj35	180	29	Fig	fig	NN
cord-002248-92pzqj35	180	30	2B-	2b-	CD
cord-002248-92pzqj35	180	31	e	e	NN
cord-002248-92pzqj35	180	32	and	and	CC
cord-002248-92pzqj35	180	33	2B	2b	CD
cord-002248-92pzqj35	180	34	-	-	HYPH
cord-002248-92pzqj35	180	35	f	f	NNP
cord-002248-92pzqj35	180	36	)	)	-RRB-
cord-002248-92pzqj35	180	37	.	.	.
cord-002248-92pzqj35	181	1	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	181	2	-	-	HYPH
cord-002248-92pzqj35	181	3	infected	infect	VBN
cord-002248-92pzqj35	181	4	cells	cell	NNS
cord-002248-92pzqj35	181	5	showed	show	VBD
cord-002248-92pzqj35	181	6	lower	low	JJR
cord-002248-92pzqj35	181	7	levels	level	NNS
cord-002248-92pzqj35	181	8	of	of	IN
cord-002248-92pzqj35	181	9	5EU	5eu	CD
cord-002248-92pzqj35	181	10	-	-	HYPH
cord-002248-92pzqj35	181	11	labeled	label	VBN
cord-002248-92pzqj35	181	12	RNA	rna	NN
cord-002248-92pzqj35	181	13	compared	compare	VBN
cord-002248-92pzqj35	181	14	with	with	IN
cord-002248-92pzqj35	181	15	those	those	DT
cord-002248-92pzqj35	181	16	in	in	IN
cord-002248-92pzqj35	181	17	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	181	18	-	-	HYPH
cord-002248-92pzqj35	181	19	infected	infect	VBN
cord-002248-92pzqj35	181	20	cells	cell	NNS
cord-002248-92pzqj35	181	21	(	(	-LRB-
cord-002248-92pzqj35	181	22	Fig	Fig	NNP
cord-002248-92pzqj35	181	23	2B	2B	NNP
cord-002248-92pzqj35	181	24	-	-	HYPH
cord-002248-92pzqj35	181	25	d	d	NN
cord-002248-92pzqj35	181	26	and	and	CC
cord-002248-92pzqj35	181	27	2B	2B	NNP
cord-002248-92pzqj35	181	28	-	-	HYPH
cord-002248-92pzqj35	181	29	f	f	NNP
cord-002248-92pzqj35	181	30	)	)	-RRB-
cord-002248-92pzqj35	181	31	.	.	.
cord-002248-92pzqj35	182	1	However	however	RB
cord-002248-92pzqj35	182	2	,	,	,
cord-002248-92pzqj35	182	3	the	the	DT
cord-002248-92pzqj35	182	4	percentage	percentage	NN
cord-002248-92pzqj35	182	5	of	of	IN
cord-002248-92pzqj35	182	6	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	182	7	-	-	HYPH
cord-002248-92pzqj35	182	8	infected	infect	VBN
cord-002248-92pzqj35	182	9	cells	cell	NNS
cord-002248-92pzqj35	182	10	with	with	IN
cord-002248-92pzqj35	182	11	low	low	JJ
cord-002248-92pzqj35	182	12	transcription	transcription	NN
cord-002248-92pzqj35	182	13	activity	activity	NN
cord-002248-92pzqj35	182	14	was	be	VBD
cord-002248-92pzqj35	182	15	43.0	43.0	CD
cord-002248-92pzqj35	182	16	%	%	NN
cord-002248-92pzqj35	182	17	(	(	-LRB-
cord-002248-92pzqj35	182	18	Q1	Q1	NNP
cord-002248-92pzqj35	182	19	/	/	SYM
cord-002248-92pzqj35	182	20	Q1+Q2	Q1+Q2	NNP
cord-002248-92pzqj35	182	21	)	)	-RRB-
cord-002248-92pzqj35	182	22	,	,	,
cord-002248-92pzqj35	182	23	while	while	IN
cord-002248-92pzqj35	182	24	in	in	IN
cord-002248-92pzqj35	182	25	the	the	DT
cord-002248-92pzqj35	182	26	MP-12	MP-12	NNP
cord-002248-92pzqj35	182	27	samples	sample	NNS
cord-002248-92pzqj35	182	28	,	,	,
cord-002248-92pzqj35	182	29	it	-PRON-	PRP
cord-002248-92pzqj35	182	30	was	be	VBD
cord-002248-92pzqj35	182	31	56.6	56.6	CD
cord-002248-92pzqj35	182	32	%	%	NN
cord-002248-92pzqj35	182	33	.	.	.
cord-002248-92pzqj35	183	1	These	these	DT
cord-002248-92pzqj35	183	2	results	result	NNS
cord-002248-92pzqj35	183	3	suggested	suggest	VBD
cord-002248-92pzqj35	183	4	that	that	IN
cord-002248-92pzqj35	183	5	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	183	6	K	K	NNP
cord-002248-92pzqj35	183	7	replication	replication	NN
cord-002248-92pzqj35	183	8	suppressed	suppress	VBD
cord-002248-92pzqj35	183	9	host	host	NN
cord-002248-92pzqj35	183	10	general	general	JJ
cord-002248-92pzqj35	183	11	transcription	transcription	NN
cord-002248-92pzqj35	183	12	,	,	,
cord-002248-92pzqj35	183	13	and	and	CC
cord-002248-92pzqj35	183	14	yet	yet	RB
cord-002248-92pzqj35	183	15	the	the	DT
cord-002248-92pzqj35	183	16	inhibitory	inhibitory	JJ
cord-002248-92pzqj35	183	17	activity	activity	NN
cord-002248-92pzqj35	183	18	of	of	IN
cord-002248-92pzqj35	183	19	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	183	20	K	K	NNP
cord-002248-92pzqj35	183	21	was	be	VBD
cord-002248-92pzqj35	183	22	weaker	weak	JJR
cord-002248-92pzqj35	183	23	than	than	IN
cord-002248-92pzqj35	183	24	that	that	DT
cord-002248-92pzqj35	183	25	of	of	IN
cord-002248-92pzqj35	183	26	MP-12	MP-12	NNP
cord-002248-92pzqj35	183	27	.	.	.
cord-002248-92pzqj35	184	1	We	-PRON-	PRP
cord-002248-92pzqj35	184	2	next	next	RB
cord-002248-92pzqj35	184	3	examined	examine	VBD
cord-002248-92pzqj35	184	4	the	the	DT
cord-002248-92pzqj35	184	5	effect	effect	NN
cord-002248-92pzqj35	184	6	of	of	IN
cord-002248-92pzqj35	184	7	differences	difference	NNS
cord-002248-92pzqj35	184	8	in	in	IN
cord-002248-92pzqj35	184	9	the	the	DT
cord-002248-92pzqj35	184	10	transcription	transcription	NN
cord-002248-92pzqj35	184	11	inhibitory	inhibitory	JJ
cord-002248-92pzqj35	184	12	activities	activity	NNS
cord-002248-92pzqj35	184	13	of	of	IN
cord-002248-92pzqj35	184	14	the	the	DT
cord-002248-92pzqj35	184	15	mutant	mutant	JJ
cord-002248-92pzqj35	184	16	viruses	virus	NNS
cord-002248-92pzqj35	184	17	on	on	IN
cord-002248-92pzqj35	184	18	global	global	JJ
cord-002248-92pzqj35	184	19	protein	protein	NN
cord-002248-92pzqj35	184	20	synthesis	synthesis	NN
cord-002248-92pzqj35	184	21	by	by	IN
cord-002248-92pzqj35	184	22	incorporation	incorporation	NN
cord-002248-92pzqj35	184	23	of	of	IN
cord-002248-92pzqj35	184	24	35	35	CD
cord-002248-92pzqj35	184	25	S	s	NN
cord-002248-92pzqj35	184	26	-	-	HYPH
cord-002248-92pzqj35	184	27	methionine	methionine	NN
cord-002248-92pzqj35	184	28	/	/	SYM
cord-002248-92pzqj35	184	29	cysteine	cysteine	NN
cord-002248-92pzqj35	184	30	into	into	IN
cord-002248-92pzqj35	184	31	newly	newly	RB
cord-002248-92pzqj35	184	32	synthesizing	synthesize	VBG
cord-002248-92pzqj35	184	33	proteins	protein	NNS
cord-002248-92pzqj35	184	34	in	in	IN
cord-002248-92pzqj35	184	35	mock	mock	NN
cord-002248-92pzqj35	184	36	-	-	HYPH
cord-002248-92pzqj35	184	37	infected	infect	VBN
cord-002248-92pzqj35	184	38	cells	cell	NNS
cord-002248-92pzqj35	184	39	and	and	CC
cord-002248-92pzqj35	184	40	in	in	IN
cord-002248-92pzqj35	184	41	cells	cell	NNS
cord-002248-92pzqj35	184	42	infected	infect	VBN
cord-002248-92pzqj35	184	43	with	with	IN
cord-002248-92pzqj35	184	44	MP-12	MP-12	NNP
cord-002248-92pzqj35	184	45	,	,	,
cord-002248-92pzqj35	184	46	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	184	47	,	,	.
cord-002248-92pzqj35	185	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	185	2	K	K	NNP
cord-002248-92pzqj35	185	3	,	,	,
cord-002248-92pzqj35	185	4	or	or	CC
cord-002248-92pzqj35	185	5	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	185	6	/	/	SYM
cord-002248-92pzqj35	185	7	M250	M250	NNP
cord-002248-92pzqj35	185	8	K	K	NNP
cord-002248-92pzqj35	185	9	(	(	-LRB-
cord-002248-92pzqj35	185	10	Fig	Fig	NNP
cord-002248-92pzqj35	185	11	2C	2c	NN
cord-002248-92pzqj35	185	12	)	)	-RRB-
cord-002248-92pzqj35	185	13	.	.	.
cord-002248-92pzqj35	186	1	Consistent	consistent	JJ
cord-002248-92pzqj35	186	2	with	with	IN
cord-002248-92pzqj35	186	3	our	-PRON-	PRP$
cord-002248-92pzqj35	186	4	previous	previous	JJ
cord-002248-92pzqj35	186	5	study	study	NN
cord-002248-92pzqj35	186	6	[	[	-LRB-
cord-002248-92pzqj35	186	7	24	24	CD
cord-002248-92pzqj35	186	8	]	]	-RRB-
cord-002248-92pzqj35	186	9	,	,	,
cord-002248-92pzqj35	186	10	MP-12	MP-12	NNP
cord-002248-92pzqj35	186	11	replication	replication	NN
cord-002248-92pzqj35	186	12	,	,	,
cord-002248-92pzqj35	186	13	but	but	CC
cord-002248-92pzqj35	186	14	not	not	RB
cord-002248-92pzqj35	186	15	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	186	16	replication	replication	NN
cord-002248-92pzqj35	186	17	,	,	,
cord-002248-92pzqj35	186	18	suppressed	suppress	VBD
cord-002248-92pzqj35	186	19	host	host	NN
cord-002248-92pzqj35	186	20	protein	protein	NN
cord-002248-92pzqj35	186	21	synthesis	synthesis	NN
cord-002248-92pzqj35	186	22	.	.	.
cord-002248-92pzqj35	187	1	MP-12-R16H/	mp-12-r16h/	XX
cord-002248-92pzqj35	188	1	M250	M250	NNP
cord-002248-92pzqj35	188	2	K	K	NNP
cord-002248-92pzqj35	188	3	replication	replication	NN
cord-002248-92pzqj35	188	4	did	do	VBD
cord-002248-92pzqj35	188	5	not	not	RB
cord-002248-92pzqj35	188	6	inhibit	inhibit	VB
cord-002248-92pzqj35	188	7	host	host	NN
cord-002248-92pzqj35	188	8	protein	protein	NN
cord-002248-92pzqj35	188	9	synthesis	synthesis	NN
cord-002248-92pzqj35	188	10	,	,	,
cord-002248-92pzqj35	188	11	while	while	IN
cord-002248-92pzqj35	188	12	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	188	13	K	K	NNP
cord-002248-92pzqj35	188	14	replication	replication	NN
cord-002248-92pzqj35	188	15	moderately	moderately	RB
cord-002248-92pzqj35	188	16	inhibited	inhibited	JJ
cord-002248-92pzqj35	188	17	host	host	NN
cord-002248-92pzqj35	188	18	protein	protein	NN
cord-002248-92pzqj35	188	19	synthesis	synthesis	NN
cord-002248-92pzqj35	188	20	.	.	.
cord-002248-92pzqj35	189	1	Taken	take	VBN
cord-002248-92pzqj35	189	2	together	together	RB
cord-002248-92pzqj35	189	3	,	,	,
cord-002248-92pzqj35	189	4	these	these	DT
cord-002248-92pzqj35	189	5	analyses	analysis	NNS
cord-002248-92pzqj35	189	6	showed	show	VBD
cord-002248-92pzqj35	189	7	that	that	IN
cord-002248-92pzqj35	189	8	NSs	nss	NN
cord-002248-92pzqj35	189	9	-	-	HYPH
cord-002248-92pzqj35	189	10	R16H	R16H	NNP
cord-002248-92pzqj35	189	11	/	/	,
cord-002248-92pzqj35	189	12	M250	M250	NNP
cord-002248-92pzqj35	189	13	K	K	NNP
cord-002248-92pzqj35	189	14	lost	lose	VBD
cord-002248-92pzqj35	189	15	the	the	DT
cord-002248-92pzqj35	189	16	general	general	JJ
cord-002248-92pzqj35	189	17	transcription	transcription	NN
cord-002248-92pzqj35	189	18	suppression	suppression	NN
cord-002248-92pzqj35	189	19	activity	activity	NN
cord-002248-92pzqj35	189	20	,	,	,
cord-002248-92pzqj35	189	21	leading	lead	VBG
cord-002248-92pzqj35	189	22	to	to	IN
cord-002248-92pzqj35	189	23	efficient	efficient	JJ
cord-002248-92pzqj35	189	24	host	host	NN
cord-002248-92pzqj35	189	25	protein	protein	NN
cord-002248-92pzqj35	189	26	synthesis	synthesis	NN
cord-002248-92pzqj35	189	27	in	in	IN
cord-002248-92pzqj35	189	28	infected	infected	JJ
cord-002248-92pzqj35	189	29	cells	cell	NNS
cord-002248-92pzqj35	189	30	,	,	,
cord-002248-92pzqj35	189	31	while	while	IN
cord-002248-92pzqj35	189	32	NSs	ns	NNS
cord-002248-92pzqj35	189	33	-	-	:
cord-002248-92pzqj35	189	34	M250	M250	NNP
cord-002248-92pzqj35	189	35	K	K	NNP
cord-002248-92pzqj35	189	36	exerted	exert	VBD
cord-002248-92pzqj35	189	37	inefficient	inefficient	JJ
cord-002248-92pzqj35	189	38	general	general	JJ
cord-002248-92pzqj35	189	39	transcription	transcription	NN
cord-002248-92pzqj35	189	40	suppression	suppression	NN
cord-002248-92pzqj35	189	41	activity	activity	NN
cord-002248-92pzqj35	189	42	,	,	,
cord-002248-92pzqj35	189	43	causing	cause	VBG
cord-002248-92pzqj35	189	44	moderate	moderate	JJ
cord-002248-92pzqj35	189	45	levels	level	NNS
cord-002248-92pzqj35	189	46	of	of	IN
cord-002248-92pzqj35	189	47	host	host	NN
cord-002248-92pzqj35	189	48	protein	protein	NN
cord-002248-92pzqj35	189	49	synthesis	synthesis	NN
cord-002248-92pzqj35	189	50	inhibition	inhibition	NN
cord-002248-92pzqj35	189	51	in	in	IN
cord-002248-92pzqj35	189	52	infected	infected	JJ
cord-002248-92pzqj35	189	53	cells	cell	NNS
cord-002248-92pzqj35	189	54	.	.	.
cord-002248-92pzqj35	190	1	Analysis	analysis	NN
cord-002248-92pzqj35	190	2	of	of	IN
cord-002248-92pzqj35	190	3	replication	replication	NN
cord-002248-92pzqj35	190	4	kinetics	kinetic	NNS
cord-002248-92pzqj35	190	5	of	of	IN
cord-002248-92pzqj35	190	6	MP-12	MP-12	NNP
cord-002248-92pzqj35	190	7	,	,	,
cord-002248-92pzqj35	190	8	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	190	9	,	,	.
cord-002248-92pzqj35	191	1	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	191	2	/	/	SYM
cord-002248-92pzqj35	191	3	M250	M250	NNP
cord-002248-92pzqj35	191	4	K	K	NNP
cord-002248-92pzqj35	191	5	and	and	CC
cord-002248-92pzqj35	191	6	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	191	7	K	K	NNP
cord-002248-92pzqj35	191	8	showed	show	VBD
cord-002248-92pzqj35	191	9	that	that	IN
cord-002248-92pzqj35	191	10	all	all	DT
cord-002248-92pzqj35	191	11	viruses	virus	NNS
cord-002248-92pzqj35	191	12	replicated	replicate	VBN
cord-002248-92pzqj35	191	13	efficiently	efficiently	RB
cord-002248-92pzqj35	191	14	with	with	IN
cord-002248-92pzqj35	191	15	similar	similar	JJ
cord-002248-92pzqj35	191	16	replication	replication	NN
cord-002248-92pzqj35	191	17	kinetics	kinetic	NNS
cord-002248-92pzqj35	191	18	in	in	IN
cord-002248-92pzqj35	191	19	Vero	Vero	NNP
cord-002248-92pzqj35	191	20	E6	E6	NNP
cord-002248-92pzqj35	191	21	cells	cell	NNS
cord-002248-92pzqj35	191	22	(	(	-LRB-
cord-002248-92pzqj35	191	23	Fig	Fig	NNP
cord-002248-92pzqj35	191	24	3A	3a	CD
cord-002248-92pzqj35	191	25	)	)	-RRB-
cord-002248-92pzqj35	191	26	.	.	.
cord-002248-92pzqj35	192	1	MP-12	MP-12	NNP
cord-002248-92pzqj35	192	2	formed	form	VBD
cord-002248-92pzqj35	192	3	clear	clear	JJ
cord-002248-92pzqj35	192	4	plaques	plaque	NNS
cord-002248-92pzqj35	192	5	in	in	IN
cord-002248-92pzqj35	192	6	Vero	Vero	NNP
cord-002248-92pzqj35	192	7	E6	E6	NNP
cord-002248-92pzqj35	192	8	cells	cell	NNS
cord-002248-92pzqj35	192	9	,	,	,
cord-002248-92pzqj35	192	10	whereas	whereas	IN
cord-002248-92pzqj35	192	11	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	192	12	/	/	SYM
cord-002248-92pzqj35	192	13	M250	M250	NNP
cord-002248-92pzqj35	192	14	K	K	NNP
cord-002248-92pzqj35	192	15	and	and	CC
cord-002248-92pzqj35	192	16	MP-12-M250	mp-12-m250	NN
cord-002248-92pzqj35	192	17	K	K	NNP
cord-002248-92pzqj35	192	18	formed	form	VBD
cord-002248-92pzqj35	192	19	turbid	turbid	JJ
cord-002248-92pzqj35	192	20	-	-	HYPH
cord-002248-92pzqj35	192	21	type	type	NN
cord-002248-92pzqj35	192	22	plaques	plaque	NNS
cord-002248-92pzqj35	192	23	like	like	IN
cord-002248-92pzqj35	192	24	MP-12ΔNSs	mp-12δnss	XX
cord-002248-92pzqj35	193	1	(	(	-LRB-
cord-002248-92pzqj35	193	2	Fig	Fig	NNP
cord-002248-92pzqj35	193	3	3B	3B	NNP
cord-002248-92pzqj35	193	4	)	)	-RRB-
cord-002248-92pzqj35	193	5	,	,	,
cord-002248-92pzqj35	193	6	indicating	indicate	VBG
cord-002248-92pzqj35	193	7	that	that	IN
cord-002248-92pzqj35	193	8	the	the	DT
cord-002248-92pzqj35	193	9	R16H/	R16H/	NNP
cord-002248-92pzqj35	193	10	M250	M250	NNP
cord-002248-92pzqj35	193	11	K	K	NNP
cord-002248-92pzqj35	193	12	mutation	mutation	NN
cord-002248-92pzqj35	193	13	and	and	CC
cord-002248-92pzqj35	193	14	the	the	DT
cord-002248-92pzqj35	193	15	M250	M250	NNP
cord-002248-92pzqj35	193	16	K	K	NNP
cord-002248-92pzqj35	193	17	mutation	mutation	NN
cord-002248-92pzqj35	193	18	in	in	IN
cord-002248-92pzqj35	193	19	NSs	NSs	NNP
cord-002248-92pzqj35	193	20	affected	affect	VBD
cord-002248-92pzqj35	193	21	virus	virus	NN
cord-002248-92pzqj35	193	22	-	-	HYPH
cord-002248-92pzqj35	193	23	induced	induce	VBN
cord-002248-92pzqj35	193	24	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	193	25	.	.	.
cord-002248-92pzqj35	194	1	Cell	cell	NN
cord-002248-92pzqj35	194	2	viability	viability	NN
cord-002248-92pzqj35	194	3	assays	assay	NNS
cord-002248-92pzqj35	194	4	showed	show	VBD
cord-002248-92pzqj35	194	5	that	that	IN
cord-002248-92pzqj35	194	6	MP-12	MP-12	NNP
cord-002248-92pzqj35	194	7	replication	replication	NN
cord-002248-92pzqj35	194	8	caused	cause	VBD
cord-002248-92pzqj35	194	9	a	a	DT
cord-002248-92pzqj35	194	10	90	90	CD
cord-002248-92pzqj35	194	11	%	%	NN
cord-002248-92pzqj35	194	12	reduction	reduction	NN
cord-002248-92pzqj35	194	13	in	in	IN
cord-002248-92pzqj35	194	14	cell	cell	NN
cord-002248-92pzqj35	194	15	viability	viability	NN
cord-002248-92pzqj35	194	16	as	as	IN
cord-002248-92pzqj35	194	17	compared	compare	VBN
cord-002248-92pzqj35	194	18	with	with	IN
cord-002248-92pzqj35	194	19	mock	mock	JJ
cord-002248-92pzqj35	194	20	-	-	HYPH
cord-002248-92pzqj35	194	21	infected	infect	VBN
cord-002248-92pzqj35	194	22	cells	cell	NNS
cord-002248-92pzqj35	194	23	at	at	IN
cord-002248-92pzqj35	194	24	72	72	CD
cord-002248-92pzqj35	194	25	h	h	NN
cord-002248-92pzqj35	194	26	p.i	p.i	NNP
cord-002248-92pzqj35	194	27	.	.	.
cord-002248-92pzqj35	195	1	(	(	-LRB-
cord-002248-92pzqj35	195	2	Fig	Fig	NNP
cord-002248-92pzqj35	195	3	3C	3C	NNP
cord-002248-92pzqj35	195	4	)	)	-RRB-
cord-002248-92pzqj35	195	5	,	,	.
cord-002248-92pzqj35	196	1	whereas	whereas	IN
cord-002248-92pzqj35	196	2	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	196	3	-	-	HYPH
cord-002248-92pzqj35	196	4	infected	infect	VBN
cord-002248-92pzqj35	196	5	cells	cell	NNS
cord-002248-92pzqj35	196	6	and	and	CC
cord-002248-92pzqj35	196	7	mock	mock	JJ
cord-002248-92pzqj35	196	8	-	-	HYPH
cord-002248-92pzqj35	196	9	infected	infect	VBN
cord-002248-92pzqj35	196	10	cells	cell	NNS
cord-002248-92pzqj35	196	11	showed	show	VBD
cord-002248-92pzqj35	196	12	similar	similar	JJ
cord-002248-92pzqj35	196	13	cell	cell	NN
cord-002248-92pzqj35	196	14	viabilities	viability	NNS
cord-002248-92pzqj35	196	15	throughout	throughout	IN
cord-002248-92pzqj35	196	16	the	the	DT
cord-002248-92pzqj35	196	17	course	course	NN
cord-002248-92pzqj35	196	18	of	of	IN
cord-002248-92pzqj35	196	19	the	the	DT
cord-002248-92pzqj35	196	20	experiments	experiment	NNS
cord-002248-92pzqj35	196	21	.	.	.
cord-002248-92pzqj35	197	1	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	197	2	/	/	SYM
cord-002248-92pzqj35	197	3	M250K	M250K	NNP
cord-002248-92pzqj35	197	4	-	-	HYPH
cord-002248-92pzqj35	197	5	infected	infect	VBN
cord-002248-92pzqj35	197	6	cells	cell	NNS
cord-002248-92pzqj35	197	7	and	and	CC
cord-002248-92pzqj35	197	8	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	197	9	-	-	HYPH
cord-002248-92pzqj35	197	10	infected	infect	VBN
cord-002248-92pzqj35	197	11	cells	cell	NNS
cord-002248-92pzqj35	197	12	showed	show	VBD
cord-002248-92pzqj35	197	13	an	an	DT
cord-002248-92pzqj35	197	14	11	11	CD
cord-002248-92pzqj35	197	15	%	%	NN
cord-002248-92pzqj35	197	16	and	and	CC
cord-002248-92pzqj35	197	17	39	39	CD
cord-002248-92pzqj35	197	18	%	%	NN
cord-002248-92pzqj35	197	19	decrease	decrease	NN
cord-002248-92pzqj35	197	20	in	in	IN
cord-002248-92pzqj35	197	21	cell	cell	NN
cord-002248-92pzqj35	197	22	viability	viability	NN
cord-002248-92pzqj35	197	23	,	,	,
cord-002248-92pzqj35	197	24	respectively	respectively	RB
cord-002248-92pzqj35	197	25	,	,	,
cord-002248-92pzqj35	197	26	as	as	IN
cord-002248-92pzqj35	197	27	compared	compare	VBN
cord-002248-92pzqj35	197	28	with	with	IN
cord-002248-92pzqj35	197	29	that	that	DT
cord-002248-92pzqj35	197	30	in	in	IN
cord-002248-92pzqj35	197	31	mock	mock	JJ
cord-002248-92pzqj35	197	32	-	-	HYPH
cord-002248-92pzqj35	197	33	infected	infect	VBN
cord-002248-92pzqj35	197	34	cells	cell	NNS
cord-002248-92pzqj35	197	35	at	at	IN
cord-002248-92pzqj35	197	36	72	72	CD
cord-002248-92pzqj35	197	37	h	h	NN
cord-002248-92pzqj35	197	38	p.i	p.i	NNP
cord-002248-92pzqj35	197	39	.	.	NNP
cord-002248-92pzqj35	197	40	,	,	,
cord-002248-92pzqj35	197	41	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	197	42	that	that	IN
cord-002248-92pzqj35	197	43	both	both	DT
cord-002248-92pzqj35	197	44	of	of	IN
cord-002248-92pzqj35	197	45	the	the	DT
cord-002248-92pzqj35	197	46	mutant	mutant	JJ
cord-002248-92pzqj35	197	47	viruses	virus	NNS
cord-002248-92pzqj35	197	48	were	be	VBD
cord-002248-92pzqj35	197	49	less	less	RBR
cord-002248-92pzqj35	197	50	cytotoxic	cytotoxic	JJ
cord-002248-92pzqj35	197	51	than	than	IN
cord-002248-92pzqj35	198	1	MP-12	MP-12	NNP
cord-002248-92pzqj35	198	2	.	.	.
cord-002248-92pzqj35	198	3	MP-12	MP-12	NNP
cord-002248-92pzqj35	198	4	,	,	,
cord-002248-92pzqj35	198	5	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	198	6	K	K	NNP
cord-002248-92pzqj35	198	7	and	and	CC
cord-002248-92pzqj35	198	8	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	198	9	/	/	SYM
cord-002248-92pzqj35	198	10	M250	M250	NNP
cord-002248-92pzqj35	198	11	K	K	NNP
cord-002248-92pzqj35	198	12	had	have	VBD
cord-002248-92pzqj35	198	13	similar	similar	JJ
cord-002248-92pzqj35	198	14	replication	replication	NN
cord-002248-92pzqj35	198	15	kinetics	kinetic	NNS
cord-002248-92pzqj35	198	16	,	,	,
cord-002248-92pzqj35	198	17	regardless	regardless	RB
cord-002248-92pzqj35	198	18	of	of	IN
cord-002248-92pzqj35	198	19	their	-PRON-	PRP$
cord-002248-92pzqj35	198	20	differential	differential	JJ
cord-002248-92pzqj35	198	21	ability	ability	NN
cord-002248-92pzqj35	198	22	to	to	TO
cord-002248-92pzqj35	198	23	induce	induce	VB
cord-002248-92pzqj35	198	24	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	198	25	(	(	-LRB-
cord-002248-92pzqj35	198	26	Fig	Fig	NNP
cord-002248-92pzqj35	198	27	3	3	CD
cord-002248-92pzqj35	198	28	)	)	-RRB-
cord-002248-92pzqj35	198	29	,	,	,
cord-002248-92pzqj35	198	30	implying	imply	VBG
cord-002248-92pzqj35	198	31	that	that	IN
cord-002248-92pzqj35	198	32	virus	virus	NN
cord-002248-92pzqj35	198	33	-	-	HYPH
cord-002248-92pzqj35	198	34	induced	induce	VBN
cord-002248-92pzqj35	198	35	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	198	36	did	do	VBD
cord-002248-92pzqj35	198	37	not	not	RB
cord-002248-92pzqj35	198	38	have	have	VB
cord-002248-92pzqj35	198	39	a	a	DT
cord-002248-92pzqj35	198	40	significant	significant	JJ
cord-002248-92pzqj35	198	41	impact	impact	NN
cord-002248-92pzqj35	198	42	on	on	IN
cord-002248-92pzqj35	198	43	RVFV	RVFV	NNP
cord-002248-92pzqj35	198	44	replication	replication	NN
cord-002248-92pzqj35	198	45	kinetics	kinetic	NNS
cord-002248-92pzqj35	198	46	in	in	IN
cord-002248-92pzqj35	198	47	Vero	Vero	NNP
cord-002248-92pzqj35	198	48	E6	E6	NNP
cord-002248-92pzqj35	198	49	cells	cell	NNS
cord-002248-92pzqj35	198	50	.	.	.
cord-002248-92pzqj35	199	1	Because	because	IN
cord-002248-92pzqj35	199	2	others	other	NNS
cord-002248-92pzqj35	199	3	reported	report	VBD
cord-002248-92pzqj35	199	4	that	that	IN
cord-002248-92pzqj35	199	5	MP-12	MP-12	NNP
cord-002248-92pzqj35	199	6	replication	replication	NN
cord-002248-92pzqj35	199	7	induces	induce	VBZ
cord-002248-92pzqj35	199	8	NSs	nss	NN
cord-002248-92pzqj35	199	9	-	-	HYPH
cord-002248-92pzqj35	199	10	dependent	dependent	JJ
cord-002248-92pzqj35	199	11	p53	p53	NN
cord-002248-92pzqj35	199	12	stabilization	stabilization	NN
cord-002248-92pzqj35	199	13	,	,	,
cord-002248-92pzqj35	199	14	which	which	WDT
cord-002248-92pzqj35	199	15	contributes	contribute	VBZ
cord-002248-92pzqj35	199	16	to	to	IN
cord-002248-92pzqj35	199	17	virus	virus	NN
cord-002248-92pzqj35	199	18	-	-	HYPH
cord-002248-92pzqj35	199	19	induced	induce	VBN
cord-002248-92pzqj35	199	20	cell	cell	NN
cord-002248-92pzqj35	199	21	death	death	NN
cord-002248-92pzqj35	199	22	[	[	-LRB-
cord-002248-92pzqj35	199	23	21	21	CD
cord-002248-92pzqj35	199	24	]	]	-RRB-
cord-002248-92pzqj35	199	25	,	,	,
cord-002248-92pzqj35	199	26	we	-PRON-	PRP
cord-002248-92pzqj35	199	27	next	next	RB
cord-002248-92pzqj35	199	28	examined	examine	VBD
cord-002248-92pzqj35	199	29	stabilization	stabilization	NN
cord-002248-92pzqj35	199	30	of	of	IN
cord-002248-92pzqj35	199	31	p53	p53	NN
cord-002248-92pzqj35	199	32	in	in	IN
cord-002248-92pzqj35	199	33	cells	cell	NNS
cord-002248-92pzqj35	199	34	infected	infect	VBN
cord-002248-92pzqj35	199	35	with	with	IN
cord-002248-92pzqj35	199	36	MP-12	MP-12	NNP
cord-002248-92pzqj35	199	37	and	and	CC
cord-002248-92pzqj35	199	38	other	other	JJ
cord-002248-92pzqj35	199	39	mutant	mutant	JJ
cord-002248-92pzqj35	199	40	viruses	virus	NNS
cord-002248-92pzqj35	200	1	(	(	-LRB-
cord-002248-92pzqj35	200	2	Fig	Fig	NNP
cord-002248-92pzqj35	200	3	3D	3D	NNP
cord-002248-92pzqj35	200	4	)	)	-RRB-
cord-002248-92pzqj35	200	5	.	.	.
cord-002248-92pzqj35	201	1	Amounts	amount	NNS
cord-002248-92pzqj35	201	2	of	of	IN
cord-002248-92pzqj35	201	3	p53	p53	NN
cord-002248-92pzqj35	201	4	protein	protein	NN
cord-002248-92pzqj35	201	5	significantly	significantly	RB
cord-002248-92pzqj35	201	6	increased	increase	VBD
cord-002248-92pzqj35	201	7	in	in	IN
cord-002248-92pzqj35	201	8	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	201	9	cells	cell	NNS
cord-002248-92pzqj35	201	10	,	,	,
cord-002248-92pzqj35	201	11	but	but	CC
cord-002248-92pzqj35	201	12	not	not	RB
cord-002248-92pzqj35	201	13	in	in	IN
cord-002248-92pzqj35	201	14	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	201	15	-	-	HYPH
cord-002248-92pzqj35	201	16	infected	infect	VBN
cord-002248-92pzqj35	201	17	cells	cell	NNS
cord-002248-92pzqj35	201	18	,	,	,
cord-002248-92pzqj35	201	19	confirming	confirm	VBG
cord-002248-92pzqj35	201	20	the	the	DT
cord-002248-92pzqj35	201	21	NSs	NSs	NNP
cord-002248-92pzqj35	201	22	-	-	HYPH
cord-002248-92pzqj35	201	23	dependent	dependent	JJ
cord-002248-92pzqj35	201	24	p53	p53	NN
cord-002248-92pzqj35	201	25	stabilization	stabilization	NN
cord-002248-92pzqj35	201	26	in	in	IN
cord-002248-92pzqj35	201	27	the	the	DT
cord-002248-92pzqj35	201	28	infected	infected	JJ
cord-002248-92pzqj35	201	29	cells	cell	NNS
cord-002248-92pzqj35	201	30	.	.	.
cord-002248-92pzqj35	202	1	Accumulation	accumulation	NN
cord-002248-92pzqj35	202	2	of	of	IN
cord-002248-92pzqj35	202	3	p53	p53	NN
cord-002248-92pzqj35	202	4	also	also	RB
cord-002248-92pzqj35	202	5	occurred	occur	VBD
cord-002248-92pzqj35	202	6	in	in	IN
cord-002248-92pzqj35	202	7	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	202	8	-	-	HYPH
cord-002248-92pzqj35	202	9	infected	infect	VBN
cord-002248-92pzqj35	202	10	cells	cell	NNS
cord-002248-92pzqj35	202	11	,	,	,
cord-002248-92pzqj35	202	12	whereas	whereas	IN
cord-002248-92pzqj35	202	13	the	the	DT
cord-002248-92pzqj35	202	14	accumulation	accumulation	NN
cord-002248-92pzqj35	202	15	levels	level	NNS
cord-002248-92pzqj35	202	16	were	be	VBD
cord-002248-92pzqj35	202	17	lower	low	JJR
cord-002248-92pzqj35	202	18	than	than	IN
cord-002248-92pzqj35	202	19	those	those	DT
cord-002248-92pzqj35	202	20	in	in	IN
cord-002248-92pzqj35	202	21	 	 	_SP
cord-002248-92pzqj35	202	22	NSs	NSs	NNP
cord-002248-92pzqj35	202	23	interacts	interact	VBZ
cord-002248-92pzqj35	202	24	with	with	IN
cord-002248-92pzqj35	202	25	PKR	PKR	NNP
cord-002248-92pzqj35	202	26	and	and	CC
cord-002248-92pzqj35	202	27	triggers	trigger	VBZ
cord-002248-92pzqj35	202	28	degradation	degradation	NN
cord-002248-92pzqj35	202	29	of	of	IN
cord-002248-92pzqj35	202	30	the	the	DT
cord-002248-92pzqj35	202	31	PKR	PKR	NNP
cord-002248-92pzqj35	202	32	by	by	IN
cord-002248-92pzqj35	202	33	a	a	DT
cord-002248-92pzqj35	202	34	proteasome	proteasome	NN
cord-002248-92pzqj35	202	35	pathway	pathway	NN
cord-002248-92pzqj35	202	36	[	[	-LRB-
cord-002248-92pzqj35	202	37	15	15	CD
cord-002248-92pzqj35	202	38	]	]	-RRB-
cord-002248-92pzqj35	202	39	[	[	-LRB-
cord-002248-92pzqj35	202	40	16	16	CD
cord-002248-92pzqj35	202	41	]	]	-RRB-
cord-002248-92pzqj35	202	42	[	[	-LRB-
cord-002248-92pzqj35	202	43	17	17	CD
cord-002248-92pzqj35	202	44	]	]	-RRB-
cord-002248-92pzqj35	202	45	[	[	-LRB-
cord-002248-92pzqj35	202	46	18	18	CD
cord-002248-92pzqj35	202	47	]	]	-RRB-
cord-002248-92pzqj35	202	48	.	.	.
cord-002248-92pzqj35	203	1	To	to	TO
cord-002248-92pzqj35	203	2	investigate	investigate	VB
cord-002248-92pzqj35	203	3	whether	whether	IN
cord-002248-92pzqj35	203	4	the	the	DT
cord-002248-92pzqj35	203	5	NSs	NSs	NNP
cord-002248-92pzqj35	203	6	mutants	mutant	NNS
cord-002248-92pzqj35	203	7	retain	retain	VBP
cord-002248-92pzqj35	203	8	the	the	DT
cord-002248-92pzqj35	203	9	ability	ability	NN
cord-002248-92pzqj35	203	10	for	for	IN
cord-002248-92pzqj35	203	11	PKR	PKR	NNP
cord-002248-92pzqj35	203	12	degradation	degradation	NN
cord-002248-92pzqj35	203	13	,	,	,
cord-002248-92pzqj35	203	14	we	-PRON-	PRP
cord-002248-92pzqj35	203	15	compared	compare	VBD
cord-002248-92pzqj35	203	16	the	the	DT
cord-002248-92pzqj35	203	17	total	total	JJ
cord-002248-92pzqj35	203	18	amount	amount	NN
cord-002248-92pzqj35	203	19	of	of	IN
cord-002248-92pzqj35	203	20	PKR	PKR	NNP
cord-002248-92pzqj35	203	21	in	in	IN
cord-002248-92pzqj35	203	22	virus	virus	NN
cord-002248-92pzqj35	203	23	-	-	HYPH
cord-002248-92pzqj35	203	24	infected	infect	VBN
cord-002248-92pzqj35	203	25	cells	cell	NNS
cord-002248-92pzqj35	203	26	.	.	.
cord-002248-92pzqj35	204	1	Similar	similar	JJ
cord-002248-92pzqj35	204	2	levels	level	NNS
cord-002248-92pzqj35	204	3	of	of	IN
cord-002248-92pzqj35	204	4	reduction	reduction	NN
cord-002248-92pzqj35	204	5	in	in	IN
cord-002248-92pzqj35	204	6	the	the	DT
cord-002248-92pzqj35	204	7	amounts	amount	NNS
cord-002248-92pzqj35	204	8	of	of	IN
cord-002248-92pzqj35	204	9	PKR	PKR	NNP
cord-002248-92pzqj35	204	10	occurred	occur	VBD
cord-002248-92pzqj35	204	11	in	in	IN
cord-002248-92pzqj35	204	12	cells	cell	NNS
cord-002248-92pzqj35	204	13	infected	infect	VBN
cord-002248-92pzqj35	204	14	with	with	IN
cord-002248-92pzqj35	204	15	MP-12	MP-12	NNP
cord-002248-92pzqj35	204	16	,	,	,
cord-002248-92pzqj35	205	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	205	2	K	K	NNP
cord-002248-92pzqj35	205	3	or	or	CC
cord-002248-92pzqj35	205	4	MP-12-R16H/250	MP-12-R16H/250	NNP
cord-002248-92pzqj35	205	5	K	K	NNP
cord-002248-92pzqj35	205	6	,	,	,
cord-002248-92pzqj35	205	7	suggesting	suggest	VBG
cord-002248-92pzqj35	205	8	that	that	IN
cord-002248-92pzqj35	205	9	NSs	NSs	NNP
cord-002248-92pzqj35	205	10	-	-	HYPH
cord-002248-92pzqj35	205	11	R16H	R16H	NNP
cord-002248-92pzqj35	205	12	/	/	SYM
cord-002248-92pzqj35	205	13	M250	M250	NNP
cord-002248-92pzqj35	205	14	K	K	NNP
cord-002248-92pzqj35	205	15	and	and	CC
cord-002248-92pzqj35	205	16	NSs	NSs	NNP
cord-002248-92pzqj35	205	17	-	-	:
cord-002248-92pzqj35	205	18	M250	M250	NNP
cord-002248-92pzqj35	205	19	K	K	NNP
cord-002248-92pzqj35	205	20	promoted	promote	VBD
cord-002248-92pzqj35	205	21	PKR	PKR	NNP
cord-002248-92pzqj35	205	22	degradation	degradation	NN
cord-002248-92pzqj35	205	23	as	as	RB
cord-002248-92pzqj35	205	24	efficiently	efficiently	RB
cord-002248-92pzqj35	205	25	as	as	IN
cord-002248-92pzqj35	205	26	wt	wt	NN
cord-002248-92pzqj35	205	27	NSs	NSs	NNP
cord-002248-92pzqj35	205	28	(	(	-LRB-
cord-002248-92pzqj35	205	29	Fig	Fig	NNP
cord-002248-92pzqj35	205	30	4	4	CD
cord-002248-92pzqj35	205	31	)	)	-RRB-
cord-002248-92pzqj35	205	32	.	.	.
cord-002248-92pzqj35	206	1	Le	Le	NNP
cord-002248-92pzqj35	206	2	May	May	NNP
cord-002248-92pzqj35	206	3	et	et	NNP
cord-002248-92pzqj35	206	4	al	al	NNP
cord-002248-92pzqj35	206	5	.	.	NNP
cord-002248-92pzqj35	206	6	proposed	propose	VBD
cord-002248-92pzqj35	206	7	that	that	IN
cord-002248-92pzqj35	206	8	interaction	interaction	NN
cord-002248-92pzqj35	206	9	of	of	IN
cord-002248-92pzqj35	206	10	NSs	NSs	NNP
cord-002248-92pzqj35	206	11	with	with	IN
cord-002248-92pzqj35	206	12	SAP30	SAP30	NNP
cord-002248-92pzqj35	206	13	interferes	interfere	VBZ
cord-002248-92pzqj35	206	14	with	with	IN
cord-002248-92pzqj35	206	15	the	the	DT
cord-002248-92pzqj35	206	16	recruitment	recruitment	NN
cord-002248-92pzqj35	206	17	of	of	IN
cord-002248-92pzqj35	206	18	co	co	JJ
cord-002248-92pzqj35	206	19	-	-	JJ
cord-002248-92pzqj35	206	20	activator	activator	NN
cord-002248-92pzqj35	206	21	protein	protein	NN
cord-002248-92pzqj35	206	22	CBP	CBP	NNP
cord-002248-92pzqj35	206	23	at	at	IN
cord-002248-92pzqj35	206	24	activation	activation	NN
cord-002248-92pzqj35	206	25	sites	site	NNS
cord-002248-92pzqj35	206	26	on	on	IN
cord-002248-92pzqj35	206	27	the	the	DT
cord-002248-92pzqj35	206	28	IFN	IFN	NNP
cord-002248-92pzqj35	206	29	-	-	HYPH
cord-002248-92pzqj35	206	30	β	β	NNP
cord-002248-92pzqj35	206	31	promotor	promotor	NN
cord-002248-92pzqj35	206	32	,	,	,
cord-002248-92pzqj35	206	33	leading	lead	VBG
cord-002248-92pzqj35	206	34	to	to	IN
cord-002248-92pzqj35	206	35	the	the	DT
cord-002248-92pzqj35	206	36	inhibition	inhibition	NN
cord-002248-92pzqj35	206	37	of	of	IN
cord-002248-92pzqj35	206	38	IFN	IFN	NNP
cord-002248-92pzqj35	206	39	-	-	HYPH
cord-002248-92pzqj35	206	40	β	β	NNP
cord-002248-92pzqj35	206	41	mRNA	mrna	NN
cord-002248-92pzqj35	206	42	transcription	transcription	NN
cord-002248-92pzqj35	206	43	[	[	-LRB-
cord-002248-92pzqj35	206	44	11	11	CD
cord-002248-92pzqj35	206	45	]	]	-RRB-
cord-002248-92pzqj35	206	46	.	.	.
cord-002248-92pzqj35	207	1	To	to	TO
cord-002248-92pzqj35	207	2	investigate	investigate	VB
cord-002248-92pzqj35	207	3	the	the	DT
cord-002248-92pzqj35	207	4	ability	ability	NN
cord-002248-92pzqj35	207	5	of	of	IN
cord-002248-92pzqj35	207	6	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	207	7	/	/	SYM
cord-002248-92pzqj35	207	8	M250	M250	NNP
cord-002248-92pzqj35	207	9	K	K	NNP
cord-002248-92pzqj35	207	10	or	or	CC
cord-002248-92pzqj35	207	11	MP-12-M250	mp-12-m250	NN
cord-002248-92pzqj35	207	12	K	K	NNP
cord-002248-92pzqj35	207	13	to	to	TO
cord-002248-92pzqj35	207	14	suppress	suppress	VB
cord-002248-92pzqj35	207	15	IFN	IFN	NNP
cord-002248-92pzqj35	207	16	-	-	HYPH
cord-002248-92pzqj35	207	17	β	β	NNP
cord-002248-92pzqj35	207	18	mRNA	mrna	NN
cord-002248-92pzqj35	207	19	transcription	transcription	NN
cord-002248-92pzqj35	207	20	,	,	,
cord-002248-92pzqj35	207	21	we	-PRON-	PRP
cord-002248-92pzqj35	207	22	examined	examine	VBD
cord-002248-92pzqj35	207	23	the	the	DT
cord-002248-92pzqj35	207	24	levels	level	NNS
cord-002248-92pzqj35	207	25	of	of	IN
cord-002248-92pzqj35	207	26	IFN	IFN	NNP
cord-002248-92pzqj35	207	27	-	-	HYPH
cord-002248-92pzqj35	207	28	β	β	NNP
cord-002248-92pzqj35	207	29	mRNA	mrna	NN
cord-002248-92pzqj35	207	30	in	in	IN
cord-002248-92pzqj35	207	31	MRC-5	MRC-5	NNP
cord-002248-92pzqj35	207	32	cells	cell	NNS
cord-002248-92pzqj35	207	33	infected	infect	VBN
cord-002248-92pzqj35	207	34	with	with	IN
cord-002248-92pzqj35	207	35	MP-12	MP-12	NNP
cord-002248-92pzqj35	207	36	,	,	,
cord-002248-92pzqj35	207	37	MP-12-ΔNSs	mp-12-δnss	NN
cord-002248-92pzqj35	207	38	,	,	,
cord-002248-92pzqj35	208	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	208	2	K	K	NNP
cord-002248-92pzqj35	208	3	or	or	CC
cord-002248-92pzqj35	208	4	MP-12-R16H/250	MP-12-R16H/250	VBZ
cord-002248-92pzqj35	208	5	K	K	NNP
cord-002248-92pzqj35	208	6	at	at	IN
cord-002248-92pzqj35	208	7	various	various	JJ
cord-002248-92pzqj35	208	8	times	time	NNS
cord-002248-92pzqj35	208	9	p.i	p.i	NNP
cord-002248-92pzqj35	208	10	.	.	.
cord-002248-92pzqj35	209	1	(	(	-LRB-
cord-002248-92pzqj35	209	2	Fig	Fig	NNP
cord-002248-92pzqj35	209	3	5A	5a	NN
cord-002248-92pzqj35	209	4	)	)	-RRB-
cord-002248-92pzqj35	209	5	.	.	.
cord-002248-92pzqj35	210	1	MP-12ΔNSs	mp-12δnss	CC
cord-002248-92pzqj35	210	2	replication	replication	NN
cord-002248-92pzqj35	210	3	induced	induce	VBN
cord-002248-92pzqj35	210	4	robust	robust	JJ
cord-002248-92pzqj35	210	5	IFN	IFN	NNP
cord-002248-92pzqj35	210	6	-	-	HYPH
cord-002248-92pzqj35	210	7	β	β	NNP
cord-002248-92pzqj35	210	8	mRNA	mrna	NN
cord-002248-92pzqj35	210	9	transcription	transcription	NN
cord-002248-92pzqj35	210	10	,	,	,
cord-002248-92pzqj35	210	11	whereas	whereas	IN
cord-002248-92pzqj35	210	12	IFN	IFN	NNP
cord-002248-92pzqj35	210	13	-	-	HYPH
cord-002248-92pzqj35	210	14	β	β	NNP
cord-002248-92pzqj35	210	15	mRNA	mrna	NN
cord-002248-92pzqj35	210	16	was	be	VBD
cord-002248-92pzqj35	210	17	not	not	RB
cord-002248-92pzqj35	210	18	detectable	detectable	JJ
cord-002248-92pzqj35	210	19	in	in	IN
cord-002248-92pzqj35	210	20	MP-12-or	MP-12-or	NNP
cord-002248-92pzqj35	210	21	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	210	22	-	-	HYPH
cord-002248-92pzqj35	210	23	infected	infect	VBN
cord-002248-92pzqj35	210	24	cells	cell	NNS
cord-002248-92pzqj35	210	25	.	.	.
cord-002248-92pzqj35	211	1	In	in	IN
cord-002248-92pzqj35	211	2	contrast	contrast	NN
cord-002248-92pzqj35	211	3	,	,	,
cord-002248-92pzqj35	211	4	low	low	JJ
cord-002248-92pzqj35	211	5	levels	level	NNS
cord-002248-92pzqj35	211	6	of	of	IN
cord-002248-92pzqj35	211	7	IFN	IFN	NNP
cord-002248-92pzqj35	211	8	-	-	HYPH
cord-002248-92pzqj35	211	9	β	β	NNP
cord-002248-92pzqj35	211	10	mRNA	mrna	NN
cord-002248-92pzqj35	211	11	accumulation	accumulation	NN
cord-002248-92pzqj35	211	12	occurred	occur	VBD
cord-002248-92pzqj35	211	13	in	in	IN
cord-002248-92pzqj35	211	14	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	211	15	/	/	SYM
cord-002248-92pzqj35	211	16	M250K	m250k	NN
cord-002248-92pzqj35	211	17	-	-	HYPH
cord-002248-92pzqj35	211	18	infected	infect	VBN
cord-002248-92pzqj35	211	19	cells	cell	NNS
cord-002248-92pzqj35	211	20	,	,	,
cord-002248-92pzqj35	211	21	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	211	22	that	that	IN
cord-002248-92pzqj35	211	23	the	the	DT
cord-002248-92pzqj35	211	24	NSs	NSs	NNP
cord-002248-92pzqj35	211	25	-	-	HYPH
cord-002248-92pzqj35	211	26	R16H	R16H	NNP
cord-002248-92pzqj35	211	27	/	/	SYM
cord-002248-92pzqj35	211	28	M250	M250	NNP
cord-002248-92pzqj35	211	29	K	K	NNP
cord-002248-92pzqj35	211	30	was	be	VBD
cord-002248-92pzqj35	211	31	unable	unable	JJ
cord-002248-92pzqj35	211	32	to	to	TO
cord-002248-92pzqj35	211	33	efficiently	efficiently	RB
cord-002248-92pzqj35	211	34	inhibit	inhibit	VB
cord-002248-92pzqj35	211	35	IFN	IFN	NNP
cord-002248-92pzqj35	211	36	-	-	HYPH
cord-002248-92pzqj35	211	37	β	β	NNP
cord-002248-92pzqj35	211	38	mRNA	mrna	NN
cord-002248-92pzqj35	211	39	transcription	transcription	NN
cord-002248-92pzqj35	211	40	.	.	.
cord-002248-92pzqj35	212	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	212	2	K	K	NNP
cord-002248-92pzqj35	212	3	replicated	replicate	VBD
cord-002248-92pzqj35	212	4	as	as	RB
cord-002248-92pzqj35	212	5	efficiently	efficiently	RB
cord-002248-92pzqj35	212	6	as	as	IN
cord-002248-92pzqj35	212	7	did	do	VBD
cord-002248-92pzqj35	212	8	MP-12	MP-12	NNP
cord-002248-92pzqj35	212	9	in	in	IN
cord-002248-92pzqj35	212	10	MRC-5	MRC-5	NNP
cord-002248-92pzqj35	212	11	cells	cell	NNS
cord-002248-92pzqj35	212	12	,	,	,
cord-002248-92pzqj35	212	13	whereas	whereas	IN
cord-002248-92pzqj35	212	14	the	the	DT
cord-002248-92pzqj35	212	15	virus	virus	NN
cord-002248-92pzqj35	212	16	titer	titer	NN
cord-002248-92pzqj35	212	17	of	of	IN
cord-002248-92pzqj35	212	18	MP-12ΔNSs	MP-12ΔNSs	NNP
cord-002248-92pzqj35	212	19	was	be	VBD
cord-002248-92pzqj35	212	20	significantly	significantly	RB
cord-002248-92pzqj35	212	21	lower	low	JJR
cord-002248-92pzqj35	212	22	than	than	IN
cord-002248-92pzqj35	212	23	that	that	DT
cord-002248-92pzqj35	212	24	of	of	IN
cord-002248-92pzqj35	212	25	MP-12	MP-12	NNP
cord-002248-92pzqj35	212	26	at	at	IN
cord-002248-92pzqj35	212	27	72	72	CD
cord-002248-92pzqj35	212	28	h	h	NN
cord-002248-92pzqj35	212	29	p.i	p.i	NNP
cord-002248-92pzqj35	212	30	.	.	.
cord-002248-92pzqj35	213	1	(	(	-LRB-
cord-002248-92pzqj35	213	2	Fig	Fig	NNP
cord-002248-92pzqj35	213	3	5B	5b	NN
cord-002248-92pzqj35	213	4	)	)	-RRB-
cord-002248-92pzqj35	213	5	,	,	,
cord-002248-92pzqj35	213	6	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	213	7	the	the	DT
cord-002248-92pzqj35	213	8	efficient	efficient	JJ
cord-002248-92pzqj35	213	9	inhibition	inhibition	NN
cord-002248-92pzqj35	213	10	of	of	IN
cord-002248-92pzqj35	213	11	IFN	IFN	NNP
cord-002248-92pzqj35	213	12	-	-	HYPH
cord-002248-92pzqj35	213	13	β	β	NNP
cord-002248-92pzqj35	213	14	production	production	NN
cord-002248-92pzqj35	213	15	in	in	IN
cord-002248-92pzqj35	213	16	the	the	DT
cord-002248-92pzqj35	213	17	former	former	JJ
cord-002248-92pzqj35	213	18	,	,	,
cord-002248-92pzqj35	213	19	but	but	CC
cord-002248-92pzqj35	213	20	not	not	RB
cord-002248-92pzqj35	213	21	in	in	IN
cord-002248-92pzqj35	213	22	the	the	DT
cord-002248-92pzqj35	213	23	latter	latter	JJ
cord-002248-92pzqj35	213	24	.	.	.
cord-002248-92pzqj35	214	1	Although	although	IN
cord-002248-92pzqj35	214	2	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	214	3	/	/	SYM
cord-002248-92pzqj35	214	4	M250	M250	NNP
cord-002248-92pzqj35	214	5	K	K	NNP
cord-002248-92pzqj35	214	6	replicated	replicate	VBD
cord-002248-92pzqj35	214	7	better	well	RBR
cord-002248-92pzqj35	214	8	than	than	IN
cord-002248-92pzqj35	214	9	MP-12ΔNSs	mp-12δnss	XX
cord-002248-92pzqj35	214	10	,	,	,
cord-002248-92pzqj35	214	11	it	-PRON-	PRP
cord-002248-92pzqj35	214	12	replicated	replicate	VBD
cord-002248-92pzqj35	214	13	less	less	RBR
cord-002248-92pzqj35	214	14	efficiently	efficiently	RB
cord-002248-92pzqj35	214	15	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	214	16	/	/	SYM
cord-002248-92pzqj35	214	17	M250K	M250K	NNP
cord-002248-92pzqj35	214	18	-	-	HYPH
cord-002248-92pzqj35	214	19	Flag	Flag	NNP
cord-002248-92pzqj35	214	20	)	)	-RRB-
cord-002248-92pzqj35	214	21	.	.	.
cord-002248-92pzqj35	215	1	Cells	cell	NNS
cord-002248-92pzqj35	215	2	,	,	,
cord-002248-92pzqj35	215	3	transiently	transiently	RB
cord-002248-92pzqj35	215	4	expressing	express	VBG
cord-002248-92pzqj35	215	5	a	a	DT
cord-002248-92pzqj35	215	6	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	215	7	SAP30	SAP30	NNP
cord-002248-92pzqj35	215	8	,	,	,
cord-002248-92pzqj35	215	9	were	be	VBD
cord-002248-92pzqj35	215	10	infected	infect	VBN
cord-002248-92pzqj35	215	11	with	with	IN
cord-002248-92pzqj35	215	12	these	these	DT
cord-002248-92pzqj35	215	13	viruses	virus	NNS
cord-002248-92pzqj35	215	14	,	,	,
cord-002248-92pzqj35	215	15	and	and	CC
cord-002248-92pzqj35	215	16	the	the	DT
cord-002248-92pzqj35	215	17	co	co	NN
cord-002248-92pzqj35	215	18	-	-	NN
cord-002248-92pzqj35	215	19	localization	localization	NN
cord-002248-92pzqj35	215	20	of	of	IN
cord-002248-92pzqj35	215	21	the	the	DT
cord-002248-92pzqj35	215	22	mutated	mutated	JJ
cord-002248-92pzqj35	215	23	NSs	NSs	NNP
cord-002248-92pzqj35	215	24	protein	protein	NN
cord-002248-92pzqj35	215	25	with	with	IN
cord-002248-92pzqj35	215	26	SAP30	SAP30	NNP
cord-002248-92pzqj35	215	27	was	be	VBD
cord-002248-92pzqj35	215	28	examined	examine	VBN
cord-002248-92pzqj35	215	29	by	by	IN
cord-002248-92pzqj35	215	30	fluorescence	fluorescence	NN
cord-002248-92pzqj35	215	31	microscopy	microscopy	NN
cord-002248-92pzqj35	215	32	analysis	analysis	NN
cord-002248-92pzqj35	215	33	.	.	.
cord-002248-92pzqj35	216	1	Like	like	IN
cord-002248-92pzqj35	216	2	wt	wt	NN
cord-002248-92pzqj35	216	3	NSs	NSs	NNP
cord-002248-92pzqj35	216	4	,	,	,
cord-002248-92pzqj35	216	5	both	both	DT
cord-002248-92pzqj35	216	6	NSs	NSs	NNP
cord-002248-92pzqj35	216	7	mutants	mutant	NNS
cord-002248-92pzqj35	216	8	formed	form	VBD
cord-002248-92pzqj35	216	9	filament	filament	NN
cord-002248-92pzqj35	216	10	-	-	HYPH
cord-002248-92pzqj35	216	11	like	like	JJ
cord-002248-92pzqj35	216	12	structures	structure	NNS
cord-002248-92pzqj35	216	13	in	in	IN
cord-002248-92pzqj35	216	14	the	the	DT
cord-002248-92pzqj35	216	15	nucleus	nucleus	NN
cord-002248-92pzqj35	216	16	(	(	-LRB-
cord-002248-92pzqj35	216	17	Fig	Fig	NNP
cord-002248-92pzqj35	216	18	5C	5c	CD
cord-002248-92pzqj35	216	19	)	)	-RRB-
cord-002248-92pzqj35	216	20	.	.	.
cord-002248-92pzqj35	217	1	The	the	DT
cord-002248-92pzqj35	217	2	expressed	express	VBN
cord-002248-92pzqj35	217	3	SAP30	SAP30	NNP
cord-002248-92pzqj35	217	4	was	be	VBD
cord-002248-92pzqj35	217	5	mainly	mainly	RB
cord-002248-92pzqj35	217	6	observed	observe	VBN
cord-002248-92pzqj35	217	7	in	in	IN
cord-002248-92pzqj35	217	8	the	the	DT
cord-002248-92pzqj35	217	9	nucleus	nucleus	NN
cord-002248-92pzqj35	217	10	and	and	CC
cord-002248-92pzqj35	217	11	was	be	VBD
cord-002248-92pzqj35	217	12	co	co	JJ
cord-002248-92pzqj35	217	13	-	-	VBN
cord-002248-92pzqj35	217	14	localized	localize	VBN
cord-002248-92pzqj35	217	15	with	with	IN
cord-002248-92pzqj35	217	16	wt	wt	NN
cord-002248-92pzqj35	217	17	NSs	NSs	NNP
cord-002248-92pzqj35	217	18	and	and	CC
cord-002248-92pzqj35	217	19	both	both	DT
cord-002248-92pzqj35	217	20	mutated	mutate	VBN
cord-002248-92pzqj35	217	21	NSs	ns	NNS
cord-002248-92pzqj35	217	22	in	in	IN
cord-002248-92pzqj35	217	23	the	the	DT
cord-002248-92pzqj35	217	24	filaments	filament	NNS
cord-002248-92pzqj35	217	25	.	.	.
cord-002248-92pzqj35	218	1	We	-PRON-	PRP
cord-002248-92pzqj35	218	2	also	also	RB
cord-002248-92pzqj35	218	3	performed	perform	VBD
cord-002248-92pzqj35	218	4	co	co	JJ
cord-002248-92pzqj35	218	5	-	-	JJ
cord-002248-92pzqj35	218	6	immunoprecipitation	immunoprecipitation	JJ
cord-002248-92pzqj35	218	7	analysis	analysis	NN
cord-002248-92pzqj35	218	8	to	to	TO
cord-002248-92pzqj35	218	9	examine	examine	VB
cord-002248-92pzqj35	218	10	NSs	NSs	NNP
cord-002248-92pzqj35	218	11	-	-	HYPH
cord-002248-92pzqj35	218	12	SAP30	SAP30	NNP
cord-002248-92pzqj35	218	13	interaction	interaction	NN
cord-002248-92pzqj35	218	14	.	.	.
cord-002248-92pzqj35	219	1	As	as	IN
cord-002248-92pzqj35	219	2	a	a	DT
cord-002248-92pzqj35	219	3	negative	negative	JJ
cord-002248-92pzqj35	219	4	control	control	NN
cord-002248-92pzqj35	219	5	,	,	,
cord-002248-92pzqj35	219	6	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	219	7	Venus	Venus	NNP
cord-002248-92pzqj35	219	8	was	be	VBD
cord-002248-92pzqj35	219	9	expressed	express	VBN
cord-002248-92pzqj35	219	10	in	in	IN
cord-002248-92pzqj35	219	11	place	place	NN
cord-002248-92pzqj35	219	12	of	of	IN
cord-002248-92pzqj35	219	13	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	219	14	SAP30	SAP30	NNP
cord-002248-92pzqj35	219	15	.	.	.
cord-002248-92pzqj35	220	1	Anti	anti	JJ
cord-002248-92pzqj35	220	2	-	-	JJ
cord-002248-92pzqj35	220	3	V5	v5	JJ
cord-002248-92pzqj35	220	4	antibody	antibody	NN
cord-002248-92pzqj35	220	5	co	co	VBD
cord-002248-92pzqj35	220	6	-	-	JJ
cord-002248-92pzqj35	220	7	precipitated	precipitated	JJ
cord-002248-92pzqj35	220	8	wt	wt	NN
cord-002248-92pzqj35	220	9	NSs	NSs	NNP
cord-002248-92pzqj35	220	10	and	and	CC
cord-002248-92pzqj35	220	11	both	both	DT
cord-002248-92pzqj35	220	12	NSs	NSs	NNP
cord-002248-92pzqj35	220	13	mutants	mutant	NNS
cord-002248-92pzqj35	220	14	along	along	IN
cord-002248-92pzqj35	220	15	with	with	IN
cord-002248-92pzqj35	220	16	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	220	17	SAP30	SAP30	NNP
cord-002248-92pzqj35	220	18	,	,	,
cord-002248-92pzqj35	220	19	while	while	IN
cord-002248-92pzqj35	220	20	the	the	DT
cord-002248-92pzqj35	220	21	amounts	amount	NNS
cord-002248-92pzqj35	220	22	of	of	IN
cord-002248-92pzqj35	220	23	NSs	ns	NNS
cord-002248-92pzqj35	220	24	-	-	:
cord-002248-92pzqj35	220	25	M250	M250	NNP
cord-002248-92pzqj35	220	26	K	K	NNP
cord-002248-92pzqj35	220	27	that	that	WDT
cord-002248-92pzqj35	220	28	were	be	VBD
cord-002248-92pzqj35	220	29	co	co	JJ
cord-002248-92pzqj35	220	30	-	-	JJ
cord-002248-92pzqj35	220	31	immunoprecipitated	immunoprecipitated	JJ
cord-002248-92pzqj35	220	32	with	with	IN
cord-002248-92pzqj35	220	33	SAP30	SAP30	NNP
cord-002248-92pzqj35	220	34	were	be	VBD
cord-002248-92pzqj35	220	35	lower	low	JJR
cord-002248-92pzqj35	220	36	than	than	IN
cord-002248-92pzqj35	220	37	those	those	DT
cord-002248-92pzqj35	220	38	of	of	IN
cord-002248-92pzqj35	220	39	wt	wt	NN
cord-002248-92pzqj35	220	40	NSs	NSs	NNP
cord-002248-92pzqj35	220	41	(	(	-LRB-
cord-002248-92pzqj35	220	42	Fig	Fig	NNP
cord-002248-92pzqj35	220	43	 	 	_SP
cord-002248-92pzqj35	220	44	5D	5d	CD
cord-002248-92pzqj35	220	45	)	)	-RRB-
cord-002248-92pzqj35	220	46	.	.	.
cord-002248-92pzqj35	221	1	Anti	anti	JJ
cord-002248-92pzqj35	221	2	-	-	JJ
cord-002248-92pzqj35	221	3	V5	v5	JJ
cord-002248-92pzqj35	221	4	antibody	antibody	NN
cord-002248-92pzqj35	221	5	did	do	VBD
cord-002248-92pzqj35	221	6	not	not	RB
cord-002248-92pzqj35	221	7	co	co	VB
cord-002248-92pzqj35	221	8	-	-	VB
cord-002248-92pzqj35	221	9	precipitate	precipitate	VB
cord-002248-92pzqj35	221	10	wt	wt	NN
cord-002248-92pzqj35	221	11	NSs	ns	NNS
cord-002248-92pzqj35	221	12	along	along	IN
cord-002248-92pzqj35	221	13	with	with	IN
cord-002248-92pzqj35	221	14	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	221	15	Venus	Venus	NNP
cord-002248-92pzqj35	221	16	(	(	-LRB-
cord-002248-92pzqj35	221	17	Fig	Fig	NNP
cord-002248-92pzqj35	221	18	5D	5d	CD
cord-002248-92pzqj35	221	19	)	)	-RRB-
cord-002248-92pzqj35	221	20	.	.	.
cord-002248-92pzqj35	222	1	These	these	DT
cord-002248-92pzqj35	222	2	data	datum	NNS
cord-002248-92pzqj35	222	3	demonstrate	demonstrate	VBP
cord-002248-92pzqj35	222	4	that	that	IN
cord-002248-92pzqj35	222	5	both	both	DT
cord-002248-92pzqj35	222	6	NSs	NSs	NNP
cord-002248-92pzqj35	222	7	mutants	mutant	NNS
cord-002248-92pzqj35	222	8	bound	bind	VBN
cord-002248-92pzqj35	222	9	to	to	IN
cord-002248-92pzqj35	222	10	SAP30	SAP30	NNP
cord-002248-92pzqj35	222	11	in	in	IN
cord-002248-92pzqj35	222	12	infected	infected	JJ
cord-002248-92pzqj35	222	13	cells	cell	NNS
cord-002248-92pzqj35	222	14	.	.	.
cord-002248-92pzqj35	223	1	Taken	take	VBN
cord-002248-92pzqj35	223	2	together	together	RB
cord-002248-92pzqj35	223	3	,	,	,
cord-002248-92pzqj35	223	4	these	these	DT
cord-002248-92pzqj35	223	5	data	datum	NNS
cord-002248-92pzqj35	223	6	indicated	indicate	VBD
cord-002248-92pzqj35	223	7	that	that	IN
cord-002248-92pzqj35	223	8	NSs	NSs	NNP
cord-002248-92pzqj35	223	9	-	-	HYPH
cord-002248-92pzqj35	223	10	R16H	R16H	NNP
cord-002248-92pzqj35	223	11	/	/	SYM
cord-002248-92pzqj35	223	12	M250	M250	NNP
cord-002248-92pzqj35	223	13	K	K	NNP
cord-002248-92pzqj35	223	14	was	be	VBD
cord-002248-92pzqj35	223	15	unable	unable	JJ
cord-002248-92pzqj35	223	16	to	to	TO
cord-002248-92pzqj35	223	17	completely	completely	RB
cord-002248-92pzqj35	223	18	block	block	VB
cord-002248-92pzqj35	223	19	IFN	IFN	NNP
cord-002248-92pzqj35	223	20	-	-	HYPH
cord-002248-92pzqj35	223	21	β	β	NN
cord-002248-92pzqj35	223	22	transcription	transcription	NN
cord-002248-92pzqj35	223	23	despite	despite	IN
cord-002248-92pzqj35	223	24	its	-PRON-	PRP$
cord-002248-92pzqj35	223	25	ability	ability	NN
cord-002248-92pzqj35	223	26	to	to	TO
cord-002248-92pzqj35	223	27	bind	bind	VB
cord-002248-92pzqj35	223	28	to	to	IN
cord-002248-92pzqj35	223	29	SAP30	SAP30	NNP
cord-002248-92pzqj35	223	30	.	.	.
cord-002248-92pzqj35	224	1	Both	both	DT
cord-002248-92pzqj35	224	2	NSs	NSs	NNP
cord-002248-92pzqj35	224	3	mutants	mutant	NNS
cord-002248-92pzqj35	224	4	retained	retain	VBD
cord-002248-92pzqj35	224	5	some	some	DT
cord-002248-92pzqj35	224	6	NSs	NSs	NNP
cord-002248-92pzqj35	224	7	functions	function	NNS
cord-002248-92pzqj35	224	8	,	,	,
cord-002248-92pzqj35	224	9	including	include	VBG
cord-002248-92pzqj35	224	10	degradation	degradation	NN
cord-002248-92pzqj35	224	11	of	of	IN
cord-002248-92pzqj35	224	12	PKR	PKR	NNP
cord-002248-92pzqj35	224	13	and	and	CC
cord-002248-92pzqj35	224	14	SAP30	SAP30	NNP
cord-002248-92pzqj35	224	15	binding	bind	VBG
cord-002248-92pzqj35	224	16	,	,	,
cord-002248-92pzqj35	224	17	and	and	CC
cord-002248-92pzqj35	224	18	yet	yet	RB
cord-002248-92pzqj35	224	19	these	these	DT
cord-002248-92pzqj35	224	20	NSs	NSs	NNP
cord-002248-92pzqj35	224	21	mutants	mutant	NNS
cord-002248-92pzqj35	224	22	and	and	CC
cord-002248-92pzqj35	224	23	wt	wt	NN
cord-002248-92pzqj35	224	24	NSs	NSs	NNP
cord-002248-92pzqj35	224	25	showed	show	VBD
cord-002248-92pzqj35	224	26	different	different	JJ
cord-002248-92pzqj35	224	27	levels	level	NNS
cord-002248-92pzqj35	224	28	of	of	IN
cord-002248-92pzqj35	224	29	general	general	JJ
cord-002248-92pzqj35	224	30	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	224	31	suppression	suppression	NN
cord-002248-92pzqj35	224	32	activities	activity	NNS
cord-002248-92pzqj35	224	33	in	in	IN
cord-002248-92pzqj35	224	34	virus	virus	NN
cord-002248-92pzqj35	224	35	-	-	HYPH
cord-002248-92pzqj35	224	36	infected	infect	VBN
cord-002248-92pzqj35	224	37	cells	cell	NNS
cord-002248-92pzqj35	224	38	.	.	.
cord-002248-92pzqj35	225	1	Transcriptional	transcriptional	JJ
cord-002248-92pzqj35	225	2	suppression	suppression	NN
cord-002248-92pzqj35	225	3	activities	activity	NNS
cord-002248-92pzqj35	225	4	of	of	IN
cord-002248-92pzqj35	225	5	the	the	DT
cord-002248-92pzqj35	225	6	mutated	mutate	VBN
cord-002248-92pzqj35	225	7	NSs	ns	NNS
cord-002248-92pzqj35	225	8	were	be	VBD
cord-002248-92pzqj35	225	9	also	also	RB
cord-002248-92pzqj35	225	10	examined	examine	VBN
cord-002248-92pzqj35	225	11	in	in	IN
cord-002248-92pzqj35	225	12	cells	cell	NNS
cord-002248-92pzqj35	225	13	transiently	transiently	RB
cord-002248-92pzqj35	225	14	expressing	express	VBG
cord-002248-92pzqj35	225	15	NSs	ns	NNS
cord-002248-92pzqj35	225	16	along	along	IN
cord-002248-92pzqj35	225	17	with	with	IN
cord-002248-92pzqj35	225	18	Renilla	Renilla	NNP
cord-002248-92pzqj35	225	19	luciferase	luciferase	VBD
cord-002248-92pzqj35	225	20	from	from	IN
cord-002248-92pzqj35	225	21	co	co	JJ
cord-002248-92pzqj35	225	22	-	-	JJ
cord-002248-92pzqj35	225	23	transfected	transfecte	VBN
cord-002248-92pzqj35	225	24	plasmids	plasmid	NNS
cord-002248-92pzqj35	225	25	.	.	.
cord-002248-92pzqj35	226	1	Luciferase	luciferase	NN
cord-002248-92pzqj35	226	2	activity	activity	NN
cord-002248-92pzqj35	226	3	was	be	VBD
cord-002248-92pzqj35	226	4	strongly	strongly	RB
cord-002248-92pzqj35	226	5	inhibited	inhibit	VBN
cord-002248-92pzqj35	226	6	in	in	IN
cord-002248-92pzqj35	226	7	the	the	DT
cord-002248-92pzqj35	226	8	cells	cell	NNS
cord-002248-92pzqj35	226	9	coexpressing	coexpresse	VBG
cord-002248-92pzqj35	226	10	wt	wt	NN
cord-002248-92pzqj35	226	11	NSs	NSs	NNP
cord-002248-92pzqj35	226	12	and	and	CC
cord-002248-92pzqj35	226	13	Renilla	Renilla	NNP
cord-002248-92pzqj35	226	14	luciferase	luciferase	NN
cord-002248-92pzqj35	226	15	(	(	-LRB-
cord-002248-92pzqj35	226	16	Fig	Fig	NNP
cord-002248-92pzqj35	226	17	6A	6a	CD
cord-002248-92pzqj35	226	18	)	)	-RRB-
cord-002248-92pzqj35	226	19	.	.	.
cord-002248-92pzqj35	227	1	Consistent	consistent	JJ
cord-002248-92pzqj35	227	2	with	with	IN
cord-002248-92pzqj35	227	3	the	the	DT
cord-002248-92pzqj35	227	4	data	datum	NNS
cord-002248-92pzqj35	227	5	obtained	obtain	VBN
cord-002248-92pzqj35	227	6	from	from	IN
cord-002248-92pzqj35	227	7	infected	infected	JJ
cord-002248-92pzqj35	227	8	cells	cell	NNS
cord-002248-92pzqj35	227	9	(	(	-LRB-
cord-002248-92pzqj35	227	10	Fig	Fig	NNP
cord-002248-92pzqj35	227	11	2	2	CD
cord-002248-92pzqj35	227	12	)	)	-RRB-
cord-002248-92pzqj35	227	13	,	,	,
cord-002248-92pzqj35	227	14	NSs	nss	NN
cord-002248-92pzqj35	227	15	-	-	HYPH
cord-002248-92pzqj35	227	16	R16H	R16H	NNP
cord-002248-92pzqj35	227	17	/	/	SYM
cord-002248-92pzqj35	227	18	M250	M250	NNP
cord-002248-92pzqj35	227	19	K	K	NNP
cord-002248-92pzqj35	227	20	expression	expression	NN
cord-002248-92pzqj35	227	21	did	do	VBD
cord-002248-92pzqj35	227	22	not	not	RB
cord-002248-92pzqj35	227	23	inhibit	inhibit	VB
cord-002248-92pzqj35	227	24	luciferase	luciferase	JJ
cord-002248-92pzqj35	227	25	activity	activity	NN
cord-002248-92pzqj35	227	26	,	,	,
cord-002248-92pzqj35	227	27	whereas	whereas	IN
cord-002248-92pzqj35	227	28	NSs	ns	NNS
cord-002248-92pzqj35	227	29	-	-	:
cord-002248-92pzqj35	227	30	M250	M250	NNP
cord-002248-92pzqj35	227	31	K	K	NNP
cord-002248-92pzqj35	227	32	expression	expression	NN
cord-002248-92pzqj35	227	33	moderately	moderately	RB
cord-002248-92pzqj35	227	34	inhibited	inhibit	VBD
cord-002248-92pzqj35	227	35	the	the	DT
cord-002248-92pzqj35	227	36	luciferase	luciferase	NN
cord-002248-92pzqj35	227	37	activity	activity	NN
cord-002248-92pzqj35	227	38	.	.	.
cord-002248-92pzqj35	228	1	Western	western	JJ
cord-002248-92pzqj35	228	2	blot	blot	NN
cord-002248-92pzqj35	228	3	analysis	analysis	NN
cord-002248-92pzqj35	228	4	of	of	IN
cord-002248-92pzqj35	228	5	nuclear	nuclear	JJ
cord-002248-92pzqj35	228	6	and	and	CC
cord-002248-92pzqj35	228	7	cytoplasmic	cytoplasmic	JJ
cord-002248-92pzqj35	228	8	fractions	fraction	NNS
cord-002248-92pzqj35	228	9	from	from	IN
cord-002248-92pzqj35	228	10	virus	virus	NN
cord-002248-92pzqj35	228	11	-	-	HYPH
cord-002248-92pzqj35	228	12	infected	infect	VBN
cord-002248-92pzqj35	228	13	cells	cell	NNS
cord-002248-92pzqj35	228	14	showed	show	VBD
cord-002248-92pzqj35	228	15	that	that	IN
cord-002248-92pzqj35	228	16	like	like	UH
cord-002248-92pzqj35	228	17	wt	wt	NN
cord-002248-92pzqj35	228	18	NSs	NSs	NNP
cord-002248-92pzqj35	228	19	,	,	,
cord-002248-92pzqj35	228	20	NSs	NSs	NNP
cord-002248-92pzqj35	228	21	-	-	HYPH
cord-002248-92pzqj35	228	22	R16H	R16H	NNP
cord-002248-92pzqj35	228	23	/	/	SYM
cord-002248-92pzqj35	228	24	M250	M250	NNP
cord-002248-92pzqj35	228	25	and	and	CC
cord-002248-92pzqj35	228	26	NSs	NSs	NNP
cord-002248-92pzqj35	228	27	-	-	:
cord-002248-92pzqj35	228	28	M250	M250	NNP
cord-002248-92pzqj35	228	29	K	K	NNP
cord-002248-92pzqj35	228	30	were	be	VBD
cord-002248-92pzqj35	228	31	also	also	RB
cord-002248-92pzqj35	228	32	distributed	distribute	VBN
cord-002248-92pzqj35	228	33	in	in	IN
cord-002248-92pzqj35	228	34	both	both	CC
cord-002248-92pzqj35	228	35	the	the	DT
cord-002248-92pzqj35	228	36	nucleus	nucleus	NN
cord-002248-92pzqj35	228	37	and	and	CC
cord-002248-92pzqj35	228	38	the	the	DT
cord-002248-92pzqj35	228	39	cytoplasm	cytoplasm	NN
cord-002248-92pzqj35	228	40	(	(	-LRB-
cord-002248-92pzqj35	228	41	S1	S1	NNP
cord-002248-92pzqj35	228	42	Fig	Fig	NNP
cord-002248-92pzqj35	228	43	)	)	-RRB-
cord-002248-92pzqj35	228	44	,	,	,
cord-002248-92pzqj35	228	45	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	228	46	that	that	IN
cord-002248-92pzqj35	228	47	these	these	DT
cord-002248-92pzqj35	228	48	mutations	mutation	NNS
cord-002248-92pzqj35	228	49	did	do	VBD
cord-002248-92pzqj35	228	50	not	not	RB
cord-002248-92pzqj35	228	51	affect	affect	VB
cord-002248-92pzqj35	228	52	the	the	DT
cord-002248-92pzqj35	228	53	subcellular	subcellular	JJ
cord-002248-92pzqj35	228	54	localization	localization	NN
cord-002248-92pzqj35	228	55	of	of	IN
cord-002248-92pzqj35	228	56	NSs	NSs	NNP
cord-002248-92pzqj35	228	57	.	.	.
cord-002248-92pzqj35	229	1	These	these	DT
cord-002248-92pzqj35	229	2	data	datum	NNS
cord-002248-92pzqj35	229	3	prompted	prompt	VBD
cord-002248-92pzqj35	229	4	us	-PRON-	PRP
cord-002248-92pzqj35	229	5	to	to	TO
cord-002248-92pzqj35	229	6	further	further	RB
cord-002248-92pzqj35	229	7	examine	examine	VB
cord-002248-92pzqj35	229	8	the	the	DT
cord-002248-92pzqj35	229	9	interplay	interplay	NN
cord-002248-92pzqj35	229	10	between	between	IN
cord-002248-92pzqj35	229	11	these	these	DT
cord-002248-92pzqj35	229	12	NSs	NSs	NNP
cord-002248-92pzqj35	229	13	mutants	mutant	NNS
cord-002248-92pzqj35	229	14	and	and	CC
cord-002248-92pzqj35	229	15	a	a	DT
cord-002248-92pzqj35	229	16	form	form	NN
cord-002248-92pzqj35	229	17	of	of	IN
cord-002248-92pzqj35	229	18	host	host	NN
cord-002248-92pzqj35	229	19	transcription	transcription	NN
cord-002248-92pzqj35	229	20	machinery	machinery	NN
cord-002248-92pzqj35	229	21	,	,	,
cord-002248-92pzqj35	229	22	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	229	23	,	,	,
cord-002248-92pzqj35	229	24	as	as	IN
cord-002248-92pzqj35	229	25	other	other	JJ
cord-002248-92pzqj35	229	26	studies	study	NNS
cord-002248-92pzqj35	229	27	have	have	VBP
cord-002248-92pzqj35	229	28	shown	show	VBN
cord-002248-92pzqj35	229	29	an	an	DT
cord-002248-92pzqj35	229	30	association	association	NN
cord-002248-92pzqj35	229	31	of	of	IN
cord-002248-92pzqj35	229	32	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	229	33	with	with	IN
cord-002248-92pzqj35	229	34	NSs	ns	NNS
cord-002248-92pzqj35	229	35	in	in	IN
cord-002248-92pzqj35	229	36	the	the	DT
cord-002248-92pzqj35	229	37	NSs	NSs	NNP
cord-002248-92pzqj35	229	38	-	-	HYPH
cord-002248-92pzqj35	229	39	induced	induce	VBN
cord-002248-92pzqj35	229	40	host	host	NN
cord-002248-92pzqj35	229	41	transcription	transcription	NN
cord-002248-92pzqj35	229	42	shut	shut	NN
cord-002248-92pzqj35	229	43	-	-	HYPH
cord-002248-92pzqj35	229	44	off	off	NN
cord-002248-92pzqj35	229	45	.	.	.
cord-002248-92pzqj35	230	1	RVFV	RVFV	NNP
cord-002248-92pzqj35	230	2	NSs	NSs	NNP
cord-002248-92pzqj35	230	3	binds	bind	VBZ
cord-002248-92pzqj35	230	4	to	to	IN
cord-002248-92pzqj35	230	5	p44	p44	NN
cord-002248-92pzqj35	230	6	,	,	,
cord-002248-92pzqj35	230	7	a	a	DT
cord-002248-92pzqj35	230	8	subunit	subunit	NN
cord-002248-92pzqj35	230	9	of	of	IN
cord-002248-92pzqj35	230	10	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	230	11	,	,	,
cord-002248-92pzqj35	230	12	and	and	CC
cord-002248-92pzqj35	230	13	interferes	interfere	VBZ
cord-002248-92pzqj35	230	14	with	with	IN
cord-002248-92pzqj35	230	15	the	the	DT
cord-002248-92pzqj35	230	16	formation	formation	NN
cord-002248-92pzqj35	230	17	of	of	IN
cord-002248-92pzqj35	230	18	the	the	DT
cord-002248-92pzqj35	230	19	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	230	20	complex	complex	NN
cord-002248-92pzqj35	230	21	by	by	IN
cord-002248-92pzqj35	230	22	inhibiting	inhibit	VBG
cord-002248-92pzqj35	230	23	the	the	DT
cord-002248-92pzqj35	230	24	subsequent	subsequent	JJ
cord-002248-92pzqj35	230	25	interaction	interaction	NN
cord-002248-92pzqj35	230	26	of	of	IN
cord-002248-92pzqj35	230	27	p44	p44	NN
cord-002248-92pzqj35	230	28	and	and	CC
cord-002248-92pzqj35	230	29	XPD	XPD	NNP
cord-002248-92pzqj35	230	30	[	[	-LRB-
cord-002248-92pzqj35	230	31	12	12	CD
cord-002248-92pzqj35	230	32	]	]	-RRB-
cord-002248-92pzqj35	230	33	.	.	.
cord-002248-92pzqj35	231	1	The	the	DT
cord-002248-92pzqj35	231	2	reduction	reduction	NN
cord-002248-92pzqj35	231	3	in	in	IN
cord-002248-92pzqj35	231	4	the	the	DT
cord-002248-92pzqj35	231	5	abundance	abundance	NN
cord-002248-92pzqj35	231	6	of	of	IN
cord-002248-92pzqj35	231	7	XPD	XPD	NNP
cord-002248-92pzqj35	231	8	and	and	CC
cord-002248-92pzqj35	231	9	p44	p44	NN
cord-002248-92pzqj35	231	10	also	also	RB
cord-002248-92pzqj35	231	11	occurs	occur	VBZ
cord-002248-92pzqj35	231	12	upon	upon	IN
cord-002248-92pzqj35	231	13	RVFV	RVFV	NNP
cord-002248-92pzqj35	231	14	infection	infection	NN
cord-002248-92pzqj35	231	15	,	,	,
cord-002248-92pzqj35	231	16	although	although	IN
cord-002248-92pzqj35	231	17	the	the	DT
cord-002248-92pzqj35	231	18	mechanisms	mechanism	NNS
cord-002248-92pzqj35	231	19	that	that	WDT
cord-002248-92pzqj35	231	20	govern	govern	VBP
cord-002248-92pzqj35	231	21	the	the	DT
cord-002248-92pzqj35	231	22	reduction	reduction	NN
cord-002248-92pzqj35	231	23	of	of	IN
cord-002248-92pzqj35	231	24	these	these	DT
cord-002248-92pzqj35	231	25	proteins	protein	NNS
cord-002248-92pzqj35	231	26	are	be	VBP
cord-002248-92pzqj35	231	27	unclear	unclear	JJ
cord-002248-92pzqj35	231	28	[	[	-LRB-
cord-002248-92pzqj35	231	29	12	12	CD
cord-002248-92pzqj35	231	30	]	]	-RRB-
cord-002248-92pzqj35	231	31	.	.	.
cord-002248-92pzqj35	232	1	In	in	IN
cord-002248-92pzqj35	232	2	addition	addition	NN
cord-002248-92pzqj35	232	3	,	,	,
cord-002248-92pzqj35	232	4	NSs	NSs	NNP
cord-002248-92pzqj35	232	5	binds	bind	VBZ
cord-002248-92pzqj35	232	6	to	to	IN
cord-002248-92pzqj35	232	7	both	both	DT
cord-002248-92pzqj35	232	8	p62	p62	NN
cord-002248-92pzqj35	232	9	,	,	,
cord-002248-92pzqj35	232	10	a	a	DT
cord-002248-92pzqj35	232	11	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	232	12	subunit	subunit	NN
cord-002248-92pzqj35	232	13	,	,	,
cord-002248-92pzqj35	232	14	and	and	CC
cord-002248-92pzqj35	232	15	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	232	16	,	,	,
cord-002248-92pzqj35	232	17	a	a	DT
cord-002248-92pzqj35	232	18	component	component	NN
cord-002248-92pzqj35	232	19	of	of	IN
cord-002248-92pzqj35	232	20	E3	e3	NN
cord-002248-92pzqj35	232	21	ubiquitin	ubiquitin	NN
cord-002248-92pzqj35	232	22	ligase	ligase	NN
cord-002248-92pzqj35	232	23	,	,	,
cord-002248-92pzqj35	232	24	which	which	WDT
cord-002248-92pzqj35	232	25	leads	lead	VBZ
cord-002248-92pzqj35	232	26	to	to	IN
cord-002248-92pzqj35	232	27	p62	p62	NN
cord-002248-92pzqj35	232	28	degradation	degradation	NN
cord-002248-92pzqj35	232	29	[	[	-LRB-
cord-002248-92pzqj35	232	30	13	13	CD
cord-002248-92pzqj35	232	31	,	,	,
cord-002248-92pzqj35	232	32	14	14	CD
cord-002248-92pzqj35	232	33	]	]	-RRB-
cord-002248-92pzqj35	232	34	.	.	.
cord-002248-92pzqj35	233	1	We	-PRON-	PRP
cord-002248-92pzqj35	233	2	first	first	RB
cord-002248-92pzqj35	233	3	examined	examine	VBD
cord-002248-92pzqj35	233	4	the	the	DT
cord-002248-92pzqj35	233	5	abundance	abundance	NN
cord-002248-92pzqj35	233	6	of	of	IN
cord-002248-92pzqj35	233	7	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	233	8	components	component	NNS
cord-002248-92pzqj35	233	9	,	,	,
cord-002248-92pzqj35	233	10	including	include	VBG
cord-002248-92pzqj35	233	11	p44	p44	NN
cord-002248-92pzqj35	233	12	,	,	,
cord-002248-92pzqj35	233	13	p62	p62	NN
cord-002248-92pzqj35	233	14	and	and	CC
cord-002248-92pzqj35	233	15	XPD	XPD	NNP
cord-002248-92pzqj35	233	16	,	,	,
cord-002248-92pzqj35	233	17	in	in	IN
cord-002248-92pzqj35	233	18	infected	infected	JJ
cord-002248-92pzqj35	233	19	cells	cell	NNS
cord-002248-92pzqj35	233	20	.	.	.
cord-002248-92pzqj35	234	1	Substantial	substantial	JJ
cord-002248-92pzqj35	234	2	reduction	reduction	NN
cord-002248-92pzqj35	234	3	of	of	IN
cord-002248-92pzqj35	234	4	p62	p62	NN
cord-002248-92pzqj35	234	5	abundance	abundance	NN
cord-002248-92pzqj35	234	6	and	and	CC
cord-002248-92pzqj35	234	7	moderate	moderate	JJ
cord-002248-92pzqj35	234	8	reductions	reduction	NNS
cord-002248-92pzqj35	234	9	in	in	IN
cord-002248-92pzqj35	234	10	the	the	DT
cord-002248-92pzqj35	234	11	abundances	abundance	NNS
cord-002248-92pzqj35	234	12	of	of	IN
cord-002248-92pzqj35	234	13	p44	p44	NN
cord-002248-92pzqj35	234	14	and	and	CC
cord-002248-92pzqj35	234	15	XPD	XPD	NNP
cord-002248-92pzqj35	234	16	occurred	occur	VBD
cord-002248-92pzqj35	234	17	in	in	IN
cord-002248-92pzqj35	234	18	cells	cell	NNS
cord-002248-92pzqj35	234	19	infected	infect	VBN
cord-002248-92pzqj35	234	20	with	with	IN
cord-002248-92pzqj35	234	21	MP-12	MP-12	NNP
cord-002248-92pzqj35	234	22	,	,	,
cord-002248-92pzqj35	234	23	or	or	CC
cord-002248-92pzqj35	234	24	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	234	25	K	K	NNP
cord-002248-92pzqj35	234	26	at	at	IN
cord-002248-92pzqj35	234	27	16	16	CD
cord-002248-92pzqj35	234	28	h	h	NN
cord-002248-92pzqj35	234	29	p.i	p.i	NNP
cord-002248-92pzqj35	234	30	.	.	.
cord-002248-92pzqj35	235	1	(	(	-LRB-
cord-002248-92pzqj35	235	2	Fig	Fig	NNP
cord-002248-92pzqj35	235	3	6B	6b	CD
cord-002248-92pzqj35	235	4	,	,	,
cord-002248-92pzqj35	235	5	left	left	JJ
cord-002248-92pzqj35	235	6	panels	panel	NNS
cord-002248-92pzqj35	235	7	)	)	-RRB-
cord-002248-92pzqj35	235	8	.	.	.
cord-002248-92pzqj35	236	1	In	in	IN
cord-002248-92pzqj35	236	2	contrast	contrast	NN
cord-002248-92pzqj35	236	3	,	,	,
cord-002248-92pzqj35	236	4	there	there	EX
cord-002248-92pzqj35	236	5	was	be	VBD
cord-002248-92pzqj35	236	6	no	no	DT
cord-002248-92pzqj35	236	7	substantial	substantial	JJ
cord-002248-92pzqj35	236	8	reduction	reduction	NN
cord-002248-92pzqj35	236	9	in	in	IN
cord-002248-92pzqj35	236	10	the	the	DT
cord-002248-92pzqj35	236	11	abundance	abundance	NN
cord-002248-92pzqj35	236	12	of	of	IN
cord-002248-92pzqj35	236	13	these	these	DT
cord-002248-92pzqj35	236	14	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	236	15	components	component	NNS
cord-002248-92pzqj35	236	16	in	in	IN
cord-002248-92pzqj35	236	17	cells	cell	NNS
cord-002248-92pzqj35	236	18	infected	infect	VBN
cord-002248-92pzqj35	236	19	with	with	IN
cord-002248-92pzqj35	236	20	MP-12ΔNS	MP-12ΔNS	NNP
cord-002248-92pzqj35	236	21	or	or	CC
cord-002248-92pzqj35	236	22	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	237	1	/M250K.	/M250K.	.
cord-002248-92pzqj35	238	1	The	the	DT
cord-002248-92pzqj35	238	2	same	same	JJ
cord-002248-92pzqj35	238	3	results	result	NNS
cord-002248-92pzqj35	238	4	were	be	VBD
cord-002248-92pzqj35	238	5	obtained	obtain	VBN
cord-002248-92pzqj35	238	6	when	when	WRB
cord-002248-92pzqj35	238	7	viruses	virus	NNS
cord-002248-92pzqj35	238	8	carrying	carry	VBG
cord-002248-92pzqj35	238	9	Flag	Flag	NNP
cord-002248-92pzqj35	238	10	-	-	HYPH
cord-002248-92pzqj35	238	11	tagged	tag	VBN
cord-002248-92pzqj35	238	12	NSs	ns	NNS
cord-002248-92pzqj35	238	13	were	be	VBD
cord-002248-92pzqj35	238	14	used	use	VBN
cord-002248-92pzqj35	238	15	.	.	.
cord-002248-92pzqj35	239	1	To	to	TO
cord-002248-92pzqj35	239	2	exclude	exclude	VB
cord-002248-92pzqj35	239	3	the	the	DT
cord-002248-92pzqj35	239	4	possibility	possibility	NN
cord-002248-92pzqj35	239	5	that	that	IN
cord-002248-92pzqj35	239	6	different	different	JJ
cord-002248-92pzqj35	239	7	transcription	transcription	NN
cord-002248-92pzqj35	239	8	suppression	suppression	NN
cord-002248-92pzqj35	239	9	activities	activity	NNS
cord-002248-92pzqj35	239	10	of	of	IN
cord-002248-92pzqj35	239	11	these	these	DT
cord-002248-92pzqj35	239	12	viruses	virus	NNS
cord-002248-92pzqj35	239	13	affected	affect	VBD
cord-002248-92pzqj35	239	14	the	the	DT
cord-002248-92pzqj35	239	15	results	result	NNS
cord-002248-92pzqj35	239	16	,	,	,
cord-002248-92pzqj35	239	17	we	-PRON-	PRP
cord-002248-92pzqj35	239	18	repeated	repeat	VBD
cord-002248-92pzqj35	239	19	the	the	DT
cord-002248-92pzqj35	239	20	experiments	experiment	NNS
cord-002248-92pzqj35	239	21	in	in	IN
cord-002248-92pzqj35	239	22	the	the	DT
cord-002248-92pzqj35	239	23	presence	presence	NN
cord-002248-92pzqj35	239	24	of	of	IN
cord-002248-92pzqj35	239	25	ActD	ActD	NNP
cord-002248-92pzqj35	239	26	and	and	CC
cord-002248-92pzqj35	239	27	obtained	obtain	VBD
cord-002248-92pzqj35	239	28	similar	similar	JJ
cord-002248-92pzqj35	239	29	results	result	NNS
cord-002248-92pzqj35	239	30	(	(	-LRB-
cord-002248-92pzqj35	239	31	Fig	Fig	NNP
cord-002248-92pzqj35	239	32	6B	6b	CD
cord-002248-92pzqj35	239	33	,	,	,
cord-002248-92pzqj35	239	34	right	right	JJ
cord-002248-92pzqj35	239	35	 	 	_SP
cord-002248-92pzqj35	239	36	panels	panel	NNS
cord-002248-92pzqj35	239	37	)	)	-RRB-
cord-002248-92pzqj35	239	38	.	.	.
cord-002248-92pzqj35	240	1	Next	next	RB
cord-002248-92pzqj35	240	2	,	,	,
cord-002248-92pzqj35	240	3	we	-PRON-	PRP
cord-002248-92pzqj35	240	4	tested	test	VBD
cord-002248-92pzqj35	240	5	the	the	DT
cord-002248-92pzqj35	240	6	interaction	interaction	NN
cord-002248-92pzqj35	240	7	of	of	IN
cord-002248-92pzqj35	240	8	mutated	mutate	VBN
cord-002248-92pzqj35	240	9	NSs	ns	NNS
cord-002248-92pzqj35	240	10	with	with	IN
cord-002248-92pzqj35	240	11	p44	p44	CD
cord-002248-92pzqj35	240	12	and	and	CC
cord-002248-92pzqj35	240	13	p62	p62	NN
cord-002248-92pzqj35	240	14	.	.	.
cord-002248-92pzqj35	241	1	Cells	cell	NNS
cord-002248-92pzqj35	241	2	infected	infect	VBN
cord-002248-92pzqj35	241	3	with	with	IN
cord-002248-92pzqj35	241	4	MP-12	MP-12	NNP
cord-002248-92pzqj35	241	5	or	or	CC
cord-002248-92pzqj35	241	6	its	-PRON-	PRP$
cord-002248-92pzqj35	241	7	mutants	mutant	NNS
cord-002248-92pzqj35	241	8	,	,	,
cord-002248-92pzqj35	241	9	all	all	DT
cord-002248-92pzqj35	241	10	of	of	IN
cord-002248-92pzqj35	241	11	which	which	WDT
cord-002248-92pzqj35	241	12	carried	carry	VBD
cord-002248-92pzqj35	241	13	Flag	Flag	NNP
cord-002248-92pzqj35	241	14	-	-	HYPH
cord-002248-92pzqj35	241	15	tagged	tag	VBN
cord-002248-92pzqj35	241	16	NSs	NSs	NNP
cord-002248-92pzqj35	241	17	,	,	,
cord-002248-92pzqj35	241	18	were	be	VBD
cord-002248-92pzqj35	241	19	subjected	subject	VBN
cord-002248-92pzqj35	241	20	to	to	TO
cord-002248-92pzqj35	241	21	co	co	VB
cord-002248-92pzqj35	241	22	-	-	VB
cord-002248-92pzqj35	241	23	immunoprecipitation	immunoprecipitation	JJ
cord-002248-92pzqj35	241	24	analysis	analysis	NN
cord-002248-92pzqj35	241	25	using	use	VBG
cord-002248-92pzqj35	241	26	anti	anti	JJ
cord-002248-92pzqj35	241	27	-	-	JJ
cord-002248-92pzqj35	241	28	p44	p44	JJ
cord-002248-92pzqj35	241	29	antibody	antibody	NN
cord-002248-92pzqj35	241	30	(	(	-LRB-
cord-002248-92pzqj35	241	31	Fig	Fig	NNP
cord-002248-92pzqj35	241	32	6C	6c	NN
cord-002248-92pzqj35	241	33	)	)	-RRB-
cord-002248-92pzqj35	241	34	.	.	.
cord-002248-92pzqj35	242	1	Anti	anti	JJ
cord-002248-92pzqj35	242	2	-	-	JJ
cord-002248-92pzqj35	242	3	p44	p44	JJ
cord-002248-92pzqj35	242	4	antibody	antibody	NN
cord-002248-92pzqj35	242	5	co	co	NN
cord-002248-92pzqj35	242	6	-	-	JJ
cord-002248-92pzqj35	242	7	immunoprecipitated	immunoprecipitated	JJ
cord-002248-92pzqj35	242	8	wt	wt	NN
cord-002248-92pzqj35	242	9	NSs	NSs	NNP
cord-002248-92pzqj35	242	10	and	and	CC
cord-002248-92pzqj35	242	11	both	both	CC
cord-002248-92pzqj35	242	12	mutant	mutant	JJ
cord-002248-92pzqj35	242	13	NSs	ns	NNS
cord-002248-92pzqj35	242	14	along	along	IN
cord-002248-92pzqj35	242	15	with	with	IN
cord-002248-92pzqj35	242	16	p44	p44	NN
cord-002248-92pzqj35	242	17	,	,	,
cord-002248-92pzqj35	242	18	whereas	whereas	IN
cord-002248-92pzqj35	242	19	control	control	NN
cord-002248-92pzqj35	242	20	anti	anti	JJ
cord-002248-92pzqj35	242	21	-	-	JJ
cord-002248-92pzqj35	242	22	H2	H2	NNP
cord-002248-92pzqj35	242	23	K	K	NNP
cord-002248-92pzqj35	242	24	antibody	antibody	NN
cord-002248-92pzqj35	242	25	precipitated	precipitate	VBD
cord-002248-92pzqj35	242	26	neither	neither	CC
cord-002248-92pzqj35	242	27	p44	p44	NN
cord-002248-92pzqj35	242	28	nor	nor	CC
cord-002248-92pzqj35	242	29	NSs	NSs	NNP
cord-002248-92pzqj35	242	30	.	.	.
cord-002248-92pzqj35	243	1	These	these	DT
cord-002248-92pzqj35	243	2	data	datum	NNS
cord-002248-92pzqj35	243	3	demonstrated	demonstrate	VBD
cord-002248-92pzqj35	243	4	that	that	IN
cord-002248-92pzqj35	243	5	both	both	DT
cord-002248-92pzqj35	243	6	NSs	NSs	NNP
cord-002248-92pzqj35	243	7	mutants	mutant	NNS
cord-002248-92pzqj35	243	8	bound	bind	VBN
cord-002248-92pzqj35	243	9	to	to	IN
cord-002248-92pzqj35	243	10	p44	p44	NN
cord-002248-92pzqj35	243	11	.	.	.
cord-002248-92pzqj35	244	1	To	to	TO
cord-002248-92pzqj35	244	2	examine	examine	VB
cord-002248-92pzqj35	244	3	the	the	DT
cord-002248-92pzqj35	244	4	interaction	interaction	NN
cord-002248-92pzqj35	244	5	of	of	IN
cord-002248-92pzqj35	244	6	p62	p62	NN
cord-002248-92pzqj35	244	7	and	and	CC
cord-002248-92pzqj35	244	8	NSs	NSs	NNP
cord-002248-92pzqj35	244	9	,	,	,
cord-002248-92pzqj35	244	10	cells	cell	NNS
cord-002248-92pzqj35	244	11	were	be	VBD
cord-002248-92pzqj35	244	12	infected	infect	VBN
cord-002248-92pzqj35	244	13	with	with	IN
cord-002248-92pzqj35	244	14	the	the	DT
cord-002248-92pzqj35	244	15	viruses	virus	NNS
cord-002248-92pzqj35	244	16	as	as	IN
cord-002248-92pzqj35	244	17	described	describe	VBN
cord-002248-92pzqj35	244	18	above	above	RB
cord-002248-92pzqj35	244	19	,	,	,
cord-002248-92pzqj35	244	20	and	and	CC
cord-002248-92pzqj35	244	21	cell	cell	NN
cord-002248-92pzqj35	244	22	extracts	extract	NNS
cord-002248-92pzqj35	244	23	were	be	VBD
cord-002248-92pzqj35	244	24	prepared	prepare	VBN
cord-002248-92pzqj35	244	25	at	at	IN
cord-002248-92pzqj35	244	26	5	5	CD
cord-002248-92pzqj35	244	27	h	h	NN
cord-002248-92pzqj35	244	28	p.i	p.i	NNP
cord-002248-92pzqj35	244	29	.	.	NNP
cord-002248-92pzqj35	244	30	,	,	,
cord-002248-92pzqj35	244	31	when	when	WRB
cord-002248-92pzqj35	244	32	p62	p62	NN
cord-002248-92pzqj35	244	33	was	be	VBD
cord-002248-92pzqj35	244	34	still	still	RB
cord-002248-92pzqj35	244	35	detectable	detectable	JJ
cord-002248-92pzqj35	244	36	in	in	IN
cord-002248-92pzqj35	244	37	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	244	38	-	-	HYPH
cord-002248-92pzqj35	244	39	Flag	flag	NN
cord-002248-92pzqj35	244	40	-	-	HYPH
cord-002248-92pzqj35	244	41	infected	infect	VBN
cord-002248-92pzqj35	244	42	cells	cell	NNS
cord-002248-92pzqj35	244	43	(	(	-LRB-
cord-002248-92pzqj35	244	44	Fig	Fig	NNP
cord-002248-92pzqj35	244	45	6D	6d	NN
cord-002248-92pzqj35	244	46	)	)	-RRB-
cord-002248-92pzqj35	244	47	.	.	.
cord-002248-92pzqj35	245	1	Anti	anti	JJ
cord-002248-92pzqj35	245	2	-	-	JJ
cord-002248-92pzqj35	245	3	p62	p62	JJ
cord-002248-92pzqj35	245	4	antibody	antibody	NN
cord-002248-92pzqj35	245	5	,	,	,
cord-002248-92pzqj35	245	6	but	but	CC
cord-002248-92pzqj35	245	7	not	not	RB
cord-002248-92pzqj35	245	8	anti	anti	JJ
cord-002248-92pzqj35	245	9	-	-	JJ
cord-002248-92pzqj35	245	10	H2	H2	NNP
cord-002248-92pzqj35	245	11	K	K	NNP
cord-002248-92pzqj35	245	12	antibody	antibody	NN
cord-002248-92pzqj35	245	13	,	,	,
cord-002248-92pzqj35	245	14	co	co	VBN
cord-002248-92pzqj35	245	15	-	-	JJ
cord-002248-92pzqj35	245	16	immunoprecipitated	immunoprecipitated	JJ
cord-002248-92pzqj35	245	17	wt	wt	NN
cord-002248-92pzqj35	245	18	NSs	NSs	NNP
cord-002248-92pzqj35	245	19	and	and	CC
cord-002248-92pzqj35	245	20	both	both	CC
cord-002248-92pzqj35	245	21	mutant	mutant	JJ
cord-002248-92pzqj35	245	22	NSs	ns	NNS
cord-002248-92pzqj35	245	23	along	along	IN
cord-002248-92pzqj35	245	24	with	with	IN
cord-002248-92pzqj35	245	25	p62	p62	NN
cord-002248-92pzqj35	245	26	,	,	,
cord-002248-92pzqj35	245	27	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	245	28	binding	binding	NN
cord-002248-92pzqj35	245	29	of	of	IN
cord-002248-92pzqj35	245	30	the	the	DT
cord-002248-92pzqj35	245	31	mutant	mutant	JJ
cord-002248-92pzqj35	245	32	NSs	NSs	NNP
cord-002248-92pzqj35	245	33	proteins	protein	NNS
cord-002248-92pzqj35	245	34	to	to	IN
cord-002248-92pzqj35	245	35	p62	p62	NN
cord-002248-92pzqj35	245	36	.	.	.
cord-002248-92pzqj35	246	1	We	-PRON-	PRP
cord-002248-92pzqj35	246	2	noted	note	VBD
cord-002248-92pzqj35	246	3	that	that	IN
cord-002248-92pzqj35	246	4	the	the	DT
cord-002248-92pzqj35	246	5	amounts	amount	NNS
cord-002248-92pzqj35	246	6	of	of	IN
cord-002248-92pzqj35	246	7	NSs	ns	NNS
cord-002248-92pzqj35	246	8	-	-	:
cord-002248-92pzqj35	246	9	M250	M250	NNP
cord-002248-92pzqj35	246	10	K	K	NNP
cord-002248-92pzqj35	246	11	that	that	WDT
cord-002248-92pzqj35	246	12	were	be	VBD
cord-002248-92pzqj35	246	13	co	co	JJ
cord-002248-92pzqj35	246	14	-	-	JJ
cord-002248-92pzqj35	246	15	immunoprecipitated	immunoprecipitated	JJ
cord-002248-92pzqj35	246	16	with	with	IN
cord-002248-92pzqj35	246	17	p44	p44	CD
cord-002248-92pzqj35	246	18	and	and	CC
cord-002248-92pzqj35	246	19	with	with	IN
cord-002248-92pzqj35	246	20	p62	p62	NN
cord-002248-92pzqj35	246	21	were	be	VBD
cord-002248-92pzqj35	246	22	lower	low	JJR
cord-002248-92pzqj35	246	23	than	than	IN
cord-002248-92pzqj35	246	24	those	those	DT
cord-002248-92pzqj35	246	25	of	of	IN
cord-002248-92pzqj35	246	26	wt	wt	NN
cord-002248-92pzqj35	246	27	NSs	NSs	NNP
cord-002248-92pzqj35	246	28	,	,	,
cord-002248-92pzqj35	246	29	implying	imply	VBG
cord-002248-92pzqj35	246	30	that	that	IN
cord-002248-92pzqj35	246	31	the	the	DT
cord-002248-92pzqj35	246	32	binding	bind	VBG
cord-002248-92pzqj35	246	33	efficiencies	efficiency	NNS
cord-002248-92pzqj35	246	34	of	of	IN
cord-002248-92pzqj35	246	35	NSs	NSs	NNP
cord-002248-92pzqj35	246	36	-	-	:
cord-002248-92pzqj35	246	37	M250	M250	NNP
cord-002248-92pzqj35	246	38	K	K	NNP
cord-002248-92pzqj35	246	39	for	for	IN
cord-002248-92pzqj35	246	40	p44	p44	NN
cord-002248-92pzqj35	246	41	and	and	CC
cord-002248-92pzqj35	246	42	for	for	IN
cord-002248-92pzqj35	246	43	p62	p62	NN
cord-002248-92pzqj35	246	44	were	be	VBD
cord-002248-92pzqj35	246	45	lower	low	JJR
cord-002248-92pzqj35	246	46	than	than	IN
cord-002248-92pzqj35	246	47	those	those	DT
cord-002248-92pzqj35	246	48	for	for	IN
cord-002248-92pzqj35	246	49	wt	wt	NN
cord-002248-92pzqj35	246	50	NSs	NSs	NNP
cord-002248-92pzqj35	246	51	.	.	.
cord-002248-92pzqj35	247	1	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	247	2	is	be	VBZ
cord-002248-92pzqj35	247	3	an	an	DT
cord-002248-92pzqj35	247	4	interactor	interactor	NN
cord-002248-92pzqj35	247	5	of	of	IN
cord-002248-92pzqj35	247	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	247	7	NSs	NSs	NNP
cord-002248-92pzqj35	247	8	that	that	WDT
cord-002248-92pzqj35	247	9	is	be	VBZ
cord-002248-92pzqj35	247	10	engaged	engage	VBN
cord-002248-92pzqj35	247	11	in	in	IN
cord-002248-92pzqj35	247	12	the	the	DT
cord-002248-92pzqj35	247	13	degradation	degradation	NN
cord-002248-92pzqj35	247	14	of	of	IN
cord-002248-92pzqj35	247	15	p62	p62	NN
cord-002248-92pzqj35	247	16	;	;	:
cord-002248-92pzqj35	247	17	NSs	NSs	NNP
cord-002248-92pzqj35	247	18	interacts	interact	VBZ
cord-002248-92pzqj35	247	19	with	with	IN
cord-002248-92pzqj35	247	20	the	the	DT
cord-002248-92pzqj35	247	21	full	full	JJ
cord-002248-92pzqj35	247	22	-	-	HYPH
cord-002248-92pzqj35	247	23	length	length	NN
cord-002248-92pzqj35	247	24	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	247	25	protein	protein	NN
cord-002248-92pzqj35	247	26	(	(	-LRB-
cord-002248-92pzqj35	247	27	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	247	28	)	)	-RRB-
cord-002248-92pzqj35	247	29	as	as	RB
cord-002248-92pzqj35	247	30	well	well	RB
cord-002248-92pzqj35	247	31	as	as	IN
cord-002248-92pzqj35	247	32	with	with	IN
cord-002248-92pzqj35	247	33	a	a	DT
cord-002248-92pzqj35	247	34	shorter	short	JJR
cord-002248-92pzqj35	247	35	splice	splice	NN
cord-002248-92pzqj35	247	36	variant	variant	NN
cord-002248-92pzqj35	247	37	of	of	IN
cord-002248-92pzqj35	247	38	the	the	DT
cord-002248-92pzqj35	247	39	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	247	40	that	that	WDT
cord-002248-92pzqj35	247	41	lacks	lack	VBZ
cord-002248-92pzqj35	247	42	the	the	DT
cord-002248-92pzqj35	247	43	C	c	NN
cord-002248-92pzqj35	247	44	-	-	HYPH
cord-002248-92pzqj35	247	45	terminal	terminal	JJ
cord-002248-92pzqj35	247	46	acidic	acidic	JJ
cord-002248-92pzqj35	247	47	domain	domain	NN
cord-002248-92pzqj35	247	48	and	and	CC
cord-002248-92pzqj35	247	49	poly(R	poly(R	NNP
cord-002248-92pzqj35	247	50	)	)	-RRB-
cord-002248-92pzqj35	247	51	region	region	NN
cord-002248-92pzqj35	247	52	[	[	-LRB-
cord-002248-92pzqj35	247	53	14	14	CD
cord-002248-92pzqj35	247	54	]	]	-RRB-
cord-002248-92pzqj35	247	55	.	.	.
cord-002248-92pzqj35	248	1	Because	because	IN
cord-002248-92pzqj35	248	2	NSs	NSs	NNP
cord-002248-92pzqj35	248	3	-	-	HYPH
cord-002248-92pzqj35	248	4	R16H	R16H	NNP
cord-002248-92pzqj35	248	5	/	/	,
cord-002248-92pzqj35	248	6	M250	M250	NNP
cord-002248-92pzqj35	248	7	K	K	NNP
cord-002248-92pzqj35	248	8	did	do	VBD
cord-002248-92pzqj35	248	9	not	not	RB
cord-002248-92pzqj35	248	10	induce	induce	VB
cord-002248-92pzqj35	248	11	p62	p62	NN
cord-002248-92pzqj35	248	12	degradation	degradation	NN
cord-002248-92pzqj35	248	13	regardless	regardless	RB
cord-002248-92pzqj35	248	14	of	of	IN
cord-002248-92pzqj35	248	15	its	-PRON-	PRP$
cord-002248-92pzqj35	248	16	ability	ability	NN
cord-002248-92pzqj35	248	17	to	to	TO
cord-002248-92pzqj35	248	18	bind	bind	VB
cord-002248-92pzqj35	248	19	to	to	IN
cord-002248-92pzqj35	248	20	p62	p62	NN
cord-002248-92pzqj35	248	21	(	(	-LRB-
cord-002248-92pzqj35	248	22	Fig	Fig	NNP
cord-002248-92pzqj35	248	23	6D	6D	NNP
cord-002248-92pzqj35	248	24	)	)	-RRB-
cord-002248-92pzqj35	248	25	,	,	,
cord-002248-92pzqj35	248	26	we	-PRON-	PRP
cord-002248-92pzqj35	248	27	suspected	suspect	VBD
cord-002248-92pzqj35	248	28	that	that	IN
cord-002248-92pzqj35	248	29	NSs	nss	NN
cord-002248-92pzqj35	248	30	-	-	HYPH
cord-002248-92pzqj35	248	31	R16H	R16H	NNP
cord-002248-92pzqj35	248	32	/	/	,
cord-002248-92pzqj35	248	33	M250	M250	NNP
cord-002248-92pzqj35	248	34	K	K	NNP
cord-002248-92pzqj35	248	35	would	would	MD
cord-002248-92pzqj35	248	36	not	not	RB
cord-002248-92pzqj35	248	37	interact	interact	VB
cord-002248-92pzqj35	248	38	with	with	IN
cord-002248-92pzqj35	248	39	FBOX3	FBOX3	NNP
cord-002248-92pzqj35	248	40	.	.	.
cord-002248-92pzqj35	249	1	To	to	TO
cord-002248-92pzqj35	249	2	test	test	VB
cord-002248-92pzqj35	249	3	this	this	DT
cord-002248-92pzqj35	249	4	possibility	possibility	NN
cord-002248-92pzqj35	249	5	,	,	,
cord-002248-92pzqj35	249	6	cells	cell	NNS
cord-002248-92pzqj35	249	7	transiently	transiently	RB
cord-002248-92pzqj35	249	8	expressing	express	VBG
cord-002248-92pzqj35	249	9	the	the	DT
cord-002248-92pzqj35	249	10	V5-tagged	V5-tagged	NNP
cord-002248-92pzqj35	249	11	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	249	12	were	be	VBD
cord-002248-92pzqj35	249	13	mock	mock	JJ
cord-002248-92pzqj35	249	14	infected	infect	VBN
cord-002248-92pzqj35	249	15	or	or	CC
cord-002248-92pzqj35	249	16	infected	infect	VBN
cord-002248-92pzqj35	249	17	with	with	IN
cord-002248-92pzqj35	249	18	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	249	19	-	-	HYPH
cord-002248-92pzqj35	249	20	Flag	Flag	NNP
cord-002248-92pzqj35	249	21	,	,	,
cord-002248-92pzqj35	249	22	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	249	23	-	-	HYPH
cord-002248-92pzqj35	249	24	Flag	Flag	NNP
cord-002248-92pzqj35	249	25	,	,	,
cord-002248-92pzqj35	249	26	or	or	CC
cord-002248-92pzqj35	249	27	MP-12-R16	MP-12-R16	NNP
cord-002248-92pzqj35	249	28	/	/	SYM
cord-002248-92pzqj35	249	29	M250K	M250K	NNP
cord-002248-92pzqj35	249	30	-	-	HYPH
cord-002248-92pzqj35	249	31	Flag	Flag	NNP
cord-002248-92pzqj35	249	32	.	.	.
cord-002248-92pzqj35	250	1	At	at	IN
cord-002248-92pzqj35	250	2	5	5	CD
cord-002248-92pzqj35	250	3	h	h	NN
cord-002248-92pzqj35	250	4	p.i	p.i	NNP
cord-002248-92pzqj35	250	5	.	.	NNP
cord-002248-92pzqj35	250	6	,	,	,
cord-002248-92pzqj35	250	7	cell	cell	NN
cord-002248-92pzqj35	250	8	extracts	extract	NNS
cord-002248-92pzqj35	250	9	were	be	VBD
cord-002248-92pzqj35	250	10	prepared	prepare	VBN
cord-002248-92pzqj35	250	11	and	and	CC
cord-002248-92pzqj35	250	12	subjected	subject	VBN
cord-002248-92pzqj35	250	13	to	to	TO
cord-002248-92pzqj35	250	14	co	co	VB
cord-002248-92pzqj35	250	15	-	-	VB
cord-002248-92pzqj35	250	16	immunoprecipitation	immunoprecipitation	JJ
cord-002248-92pzqj35	250	17	analysis	analysis	NN
cord-002248-92pzqj35	250	18	by	by	IN
cord-002248-92pzqj35	250	19	using	use	VBG
cord-002248-92pzqj35	250	20	anti	anti	JJ
cord-002248-92pzqj35	250	21	-	-	JJ
cord-002248-92pzqj35	250	22	V5	v5	JJ
cord-002248-92pzqj35	250	23	antibody	antibody	NN
cord-002248-92pzqj35	250	24	(	(	-LRB-
cord-002248-92pzqj35	250	25	Fig	Fig	NNP
cord-002248-92pzqj35	250	26	 	 	_SP
cord-002248-92pzqj35	250	27	6E	6E	NNP
cord-002248-92pzqj35	250	28	)	)	-RRB-
cord-002248-92pzqj35	250	29	.	.	.
cord-002248-92pzqj35	251	1	All	all	DT
cord-002248-92pzqj35	251	2	of	of	IN
cord-002248-92pzqj35	251	3	the	the	DT
cord-002248-92pzqj35	251	4	NSs	NSs	NNP
cord-002248-92pzqj35	251	5	proteins	protein	NNS
cord-002248-92pzqj35	251	6	,	,	,
cord-002248-92pzqj35	251	7	including	include	VBG
cord-002248-92pzqj35	251	8	NSs	NSs	NNP
cord-002248-92pzqj35	251	9	-	-	HYPH
cord-002248-92pzqj35	251	10	R16	R16	NNP
cord-002248-92pzqj35	251	11	/	/	SYM
cord-002248-92pzqj35	251	12	M250	M250	NNP
cord-002248-92pzqj35	251	13	K	K	NNP
cord-002248-92pzqj35	251	14	,	,	,
cord-002248-92pzqj35	251	15	were	be	VBD
cord-002248-92pzqj35	251	16	co	co	JJ
cord-002248-92pzqj35	251	17	-	-	JJ
cord-002248-92pzqj35	251	18	immunoprecipitated	immunoprecipitated	JJ
cord-002248-92pzqj35	251	19	with	with	IN
cord-002248-92pzqj35	251	20	FBXO3/1	FBXO3/1	NNP
cord-002248-92pzqj35	251	21	.	.	.
cord-002248-92pzqj35	252	1	Table	table	NN
cord-002248-92pzqj35	252	2	2	2	CD
cord-002248-92pzqj35	252	3	summarizes	summarize	VBZ
cord-002248-92pzqj35	252	4	interactions	interaction	NNS
cord-002248-92pzqj35	252	5	of	of	IN
cord-002248-92pzqj35	252	6	the	the	DT
cord-002248-92pzqj35	252	7	NSs	NSs	NNP
cord-002248-92pzqj35	252	8	mutants	mutant	NNS
cord-002248-92pzqj35	252	9	with	with	IN
cord-002248-92pzqj35	252	10	p44	p44	NN
cord-002248-92pzqj35	252	11	,	,	,
cord-002248-92pzqj35	252	12	p62	p62	NN
cord-002248-92pzqj35	252	13	and	and	CC
cord-002248-92pzqj35	252	14	FBXO3	FBXO3	NNP
cord-002248-92pzqj35	252	15	.	.	.
cord-002248-92pzqj35	253	1	NSs	NSs	NNP
cord-002248-92pzqj35	253	2	is	be	VBZ
cord-002248-92pzqj35	253	3	a	a	DT
cord-002248-92pzqj35	253	4	major	major	JJ
cord-002248-92pzqj35	253	5	virulence	virulence	NN
cord-002248-92pzqj35	253	6	factor	factor	NN
cord-002248-92pzqj35	253	7	of	of	IN
cord-002248-92pzqj35	253	8	RVFV	RVFV	NNP
cord-002248-92pzqj35	253	9	[	[	-LRB-
cord-002248-92pzqj35	253	10	31	31	CD
cord-002248-92pzqj35	253	11	]	]	-RRB-
cord-002248-92pzqj35	253	12	.	.	.
cord-002248-92pzqj35	254	1	The	the	DT
cord-002248-92pzqj35	254	2	NSs	nss	NN
cord-002248-92pzqj35	254	3	-	-	HYPH
cord-002248-92pzqj35	254	4	mediated	mediate	VBN
cord-002248-92pzqj35	254	5	inhibition	inhibition	NN
cord-002248-92pzqj35	254	6	of	of	IN
cord-002248-92pzqj35	254	7	type	type	NN
cord-002248-92pzqj35	254	8	I	-PRON-	PRP
cord-002248-92pzqj35	254	9	IFN	IFN	NNP
cord-002248-92pzqj35	254	10	production	production	NN
cord-002248-92pzqj35	254	11	is	be	VBZ
cord-002248-92pzqj35	254	12	thought	think	VBN
cord-002248-92pzqj35	254	13	to	to	TO
cord-002248-92pzqj35	254	14	contribute	contribute	VB
cord-002248-92pzqj35	254	15	to	to	IN
cord-002248-92pzqj35	254	16	the	the	DT
cord-002248-92pzqj35	254	17	virulence	virulence	NN
cord-002248-92pzqj35	254	18	of	of	IN
cord-002248-92pzqj35	254	19	the	the	DT
cord-002248-92pzqj35	254	20	virus	virus	NN
cord-002248-92pzqj35	254	21	,	,	,
cord-002248-92pzqj35	254	22	yet	yet	CC
cord-002248-92pzqj35	254	23	it	-PRON-	PRP
cord-002248-92pzqj35	254	24	remains	remain	VBZ
cord-002248-92pzqj35	254	25	unclear	unclear	JJ
cord-002248-92pzqj35	254	26	whether	whether	IN
cord-002248-92pzqj35	254	27	the	the	DT
cord-002248-92pzqj35	254	28	general	general	JJ
cord-002248-92pzqj35	254	29	transcription	transcription	NN
cord-002248-92pzqj35	254	30	suppression	suppression	NN
cord-002248-92pzqj35	254	31	function	function	NN
cord-002248-92pzqj35	254	32	of	of	IN
cord-002248-92pzqj35	254	33	NSs	NSs	NNP
cord-002248-92pzqj35	254	34	contributes	contribute	VBZ
cord-002248-92pzqj35	254	35	to	to	IN
cord-002248-92pzqj35	254	36	this	this	DT
cord-002248-92pzqj35	254	37	virulence	virulence	NN
cord-002248-92pzqj35	254	38	.	.	.
cord-002248-92pzqj35	255	1	We	-PRON-	PRP
cord-002248-92pzqj35	255	2	examined	examine	VBD
cord-002248-92pzqj35	255	3	the	the	DT
cord-002248-92pzqj35	255	4	importance	importance	NN
cord-002248-92pzqj35	255	5	of	of	IN
cord-002248-92pzqj35	255	6	the	the	DT
cord-002248-92pzqj35	255	7	NSs	NSs	NNP
cord-002248-92pzqj35	255	8	-	-	HYPH
cord-002248-92pzqj35	255	9	mediated	mediate	VBN
cord-002248-92pzqj35	255	10	transcription	transcription	NN
cord-002248-92pzqj35	255	11	inhibition	inhibition	NN
cord-002248-92pzqj35	255	12	in	in	IN
cord-002248-92pzqj35	255	13	RVFV	RVFV	NNP
cord-002248-92pzqj35	255	14	virulence	virulence	NN
cord-002248-92pzqj35	255	15	by	by	IN
cord-002248-92pzqj35	255	16	using	use	VBG
cord-002248-92pzqj35	255	17	a	a	DT
cord-002248-92pzqj35	255	18	young	young	JJ
cord-002248-92pzqj35	255	19	mouse	mouse	NN
cord-002248-92pzqj35	255	20	model	model	NN
cord-002248-92pzqj35	255	21	.	.	.
cord-002248-92pzqj35	256	1	Although	although	IN
cord-002248-92pzqj35	256	2	MP-12	MP-12	NNP
cord-002248-92pzqj35	256	3	is	be	VBZ
cord-002248-92pzqj35	256	4	known	know	VBN
cord-002248-92pzqj35	256	5	as	as	IN
cord-002248-92pzqj35	256	6	an	an	DT
cord-002248-92pzqj35	256	7	attenuated	attenuated	JJ
cord-002248-92pzqj35	256	8	strain	strain	NN
cord-002248-92pzqj35	256	9	,	,	,
cord-002248-92pzqj35	256	10	the	the	DT
cord-002248-92pzqj35	256	11	intraperitoneal	intraperitoneal	JJ
cord-002248-92pzqj35	256	12	inoculation	inoculation	NN
cord-002248-92pzqj35	256	13	of	of	IN
cord-002248-92pzqj35	256	14	10	10	CD
cord-002248-92pzqj35	256	15	4	4	CD
cord-002248-92pzqj35	256	16	PFU	pfu	NN
cord-002248-92pzqj35	256	17	of	of	IN
cord-002248-92pzqj35	256	18	MP-12	MP-12	NNP
cord-002248-92pzqj35	256	19	into	into	IN
cord-002248-92pzqj35	256	20	18-day	18-day	CD
cord-002248-92pzqj35	256	21	-	-	HYPH
cord-002248-92pzqj35	256	22	old	old	JJ
cord-002248-92pzqj35	256	23	CD1	CD1	NNP
cord-002248-92pzqj35	256	24	mice	mouse	NNS
cord-002248-92pzqj35	256	25	resulted	result	VBD
cord-002248-92pzqj35	256	26	in	in	IN
cord-002248-92pzqj35	256	27	the	the	DT
cord-002248-92pzqj35	256	28	death	death	NN
cord-002248-92pzqj35	256	29	of	of	IN
cord-002248-92pzqj35	256	30	55	55	CD
cord-002248-92pzqj35	256	31	%	%	NN
cord-002248-92pzqj35	256	32	of	of	IN
cord-002248-92pzqj35	256	33	the	the	DT
cord-002248-92pzqj35	256	34	mice	mouse	NNS
cord-002248-92pzqj35	256	35	within	within	IN
cord-002248-92pzqj35	256	36	13	13	CD
cord-002248-92pzqj35	256	37	days	day	NNS
cord-002248-92pzqj35	256	38	p.i	p.i	NNP
cord-002248-92pzqj35	256	39	.	.	.
cord-002248-92pzqj35	257	1	(	(	-LRB-
cord-002248-92pzqj35	257	2	Fig	Fig	NNP
cord-002248-92pzqj35	257	3	7	7	CD
cord-002248-92pzqj35	257	4	)	)	-RRB-
cord-002248-92pzqj35	257	5	.	.	.
cord-002248-92pzqj35	258	1	Under	under	IN
cord-002248-92pzqj35	258	2	the	the	DT
cord-002248-92pzqj35	258	3	same	same	JJ
cord-002248-92pzqj35	258	4	experimental	experimental	JJ
cord-002248-92pzqj35	258	5	conditions	condition	NNS
cord-002248-92pzqj35	258	6	,	,	,
cord-002248-92pzqj35	258	7	none	none	NN
cord-002248-92pzqj35	258	8	of	of	IN
cord-002248-92pzqj35	258	9	the	the	DT
cord-002248-92pzqj35	258	10	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	258	11	/	/	SYM
cord-002248-92pzqj35	258	12	M250K	m250k	NN
cord-002248-92pzqj35	258	13	-	-	HYPH
cord-002248-92pzqj35	258	14	inoculated	inoculate	VBN
cord-002248-92pzqj35	258	15	mice	mouse	NNS
cord-002248-92pzqj35	258	16	and	and	CC
cord-002248-92pzqj35	258	17	20	20	CD
cord-002248-92pzqj35	258	18	%	%	NN
cord-002248-92pzqj35	258	19	of	of	IN
cord-002248-92pzqj35	258	20	the	the	DT
cord-002248-92pzqj35	258	21	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	258	22	-	-	HYPH
cord-002248-92pzqj35	258	23	inoculated	inoculate	VBN
cord-002248-92pzqj35	258	24	mice	mouse	NNS
cord-002248-92pzqj35	258	25	died	die	VBD
cord-002248-92pzqj35	258	26	.	.	.
cord-002248-92pzqj35	259	1	No	no	DT
cord-002248-92pzqj35	259	2	obvious	obvious	JJ
cord-002248-92pzqj35	259	3	clinical	clinical	JJ
cord-002248-92pzqj35	259	4	signs	sign	NNS
cord-002248-92pzqj35	259	5	,	,	,
cord-002248-92pzqj35	259	6	including	include	VBG
cord-002248-92pzqj35	259	7	neurological	neurological	JJ
cord-002248-92pzqj35	259	8	symptoms	symptom	NNS
cord-002248-92pzqj35	259	9	,	,	,
cord-002248-92pzqj35	259	10	were	be	VBD
cord-002248-92pzqj35	259	11	observed	observe	VBN
cord-002248-92pzqj35	259	12	.	.	.
cord-002248-92pzqj35	260	1	These	these	DT
cord-002248-92pzqj35	260	2	data	datum	NNS
cord-002248-92pzqj35	260	3	demonstrated	demonstrate	VBD
cord-002248-92pzqj35	260	4	that	that	IN
cord-002248-92pzqj35	260	5	the	the	DT
cord-002248-92pzqj35	260	6	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	260	7	/	/	SYM
cord-002248-92pzqj35	260	8	M250	M250	NNP
cord-002248-92pzqj35	260	9	K	K	NNP
cord-002248-92pzqj35	260	10	lacked	lack	VBD
cord-002248-92pzqj35	260	11	virulence	virulence	NN
cord-002248-92pzqj35	260	12	,	,	,
cord-002248-92pzqj35	260	13	and	and	CC
cord-002248-92pzqj35	260	14	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	260	15	K	K	NNP
cord-002248-92pzqj35	260	16	was	be	VBD
cord-002248-92pzqj35	260	17	less	less	RBR
cord-002248-92pzqj35	260	18	virulent	virulent	JJ
cord-002248-92pzqj35	260	19	than	than	IN
cord-002248-92pzqj35	260	20	MP-12	MP-12	NNP
cord-002248-92pzqj35	260	21	in	in	IN
cord-002248-92pzqj35	260	22	this	this	DT
cord-002248-92pzqj35	260	23	young	young	JJ
cord-002248-92pzqj35	260	24	mouse	mouse	NN
cord-002248-92pzqj35	260	25	model	model	NN
cord-002248-92pzqj35	260	26	.	.	.
cord-002248-92pzqj35	260	27	 	 	_SP
cord-002248-92pzqj35	261	1	In	in	IN
cord-002248-92pzqj35	261	2	this	this	DT
cord-002248-92pzqj35	261	3	study	study	NN
cord-002248-92pzqj35	261	4	,	,	,
cord-002248-92pzqj35	261	5	we	-PRON-	PRP
cord-002248-92pzqj35	261	6	demonstrated	demonstrate	VBD
cord-002248-92pzqj35	261	7	that	that	IN
cord-002248-92pzqj35	261	8	the	the	DT
cord-002248-92pzqj35	261	9	M250	M250	NNP
cord-002248-92pzqj35	261	10	K	K	NNP
cord-002248-92pzqj35	261	11	and	and	CC
cord-002248-92pzqj35	261	12	R16H	R16H	NNP
cord-002248-92pzqj35	261	13	/	/	,
cord-002248-92pzqj35	261	14	M250	M250	NNP
cord-002248-92pzqj35	261	15	K	K	NNP
cord-002248-92pzqj35	261	16	mutations	mutation	NNS
cord-002248-92pzqj35	261	17	in	in	IN
cord-002248-92pzqj35	261	18	NSs	NSs	NNP
cord-002248-92pzqj35	261	19	differentially	differentially	RB
cord-002248-92pzqj35	261	20	reduced	reduce	VBD
cord-002248-92pzqj35	261	21	its	-PRON-	PRP$
cord-002248-92pzqj35	261	22	inhibitory	inhibitory	JJ
cord-002248-92pzqj35	261	23	activity	activity	NN
cord-002248-92pzqj35	261	24	on	on	IN
cord-002248-92pzqj35	261	25	host	host	NN
cord-002248-92pzqj35	261	26	transcription	transcription	NN
cord-002248-92pzqj35	261	27	without	without	IN
cord-002248-92pzqj35	261	28	affecting	affect	VBG
cord-002248-92pzqj35	261	29	its	-PRON-	PRP$
cord-002248-92pzqj35	261	30	ability	ability	NN
cord-002248-92pzqj35	261	31	to	to	TO
cord-002248-92pzqj35	261	32	inhibit	inhibit	VB
cord-002248-92pzqj35	261	33	IFN	IFN	NNP
cord-002248-92pzqj35	261	34	-	-	HYPH
cord-002248-92pzqj35	261	35	β	β	NN
cord-002248-92pzqj35	261	36	transcription	transcription	NN
cord-002248-92pzqj35	261	37	,	,	,
cord-002248-92pzqj35	261	38	through	through	IN
cord-002248-92pzqj35	261	39	its	-PRON-	PRP$
cord-002248-92pzqj35	261	40	interaction	interaction	NN
cord-002248-92pzqj35	261	41	with	with	IN
cord-002248-92pzqj35	261	42	SAP30	SAP30	NNP
cord-002248-92pzqj35	261	43	,	,	,
cord-002248-92pzqj35	261	44	and	and	CC
cord-002248-92pzqj35	261	45	induced	induce	VBD
cord-002248-92pzqj35	261	46	PKR	PKR	NNP
cord-002248-92pzqj35	261	47	degradation	degradation	NN
cord-002248-92pzqj35	261	48	.	.	.
cord-002248-92pzqj35	262	1	NSs	NSs	NNP
cord-002248-92pzqj35	262	2	-	-	HYPH
cord-002248-92pzqj35	262	3	R16H	R16H	NNP
cord-002248-92pzqj35	262	4	/	/	SYM
cord-002248-92pzqj35	262	5	M250	M250	NNP
cord-002248-92pzqj35	262	6	K	K	NNP
cord-002248-92pzqj35	262	7	,	,	,
cord-002248-92pzqj35	262	8	which	which	WDT
cord-002248-92pzqj35	262	9	completely	completely	RB
cord-002248-92pzqj35	262	10	lacked	lack	VBD
cord-002248-92pzqj35	262	11	the	the	DT
cord-002248-92pzqj35	262	12	activity	activity	NN
cord-002248-92pzqj35	262	13	to	to	TO
cord-002248-92pzqj35	262	14	inhibit	inhibit	VB
cord-002248-92pzqj35	262	15	general	general	JJ
cord-002248-92pzqj35	262	16	transcription	transcription	NN
cord-002248-92pzqj35	262	17	,	,	,
cord-002248-92pzqj35	262	18	correspondingly	correspondingly	RB
cord-002248-92pzqj35	262	19	lost	lose	VBD
cord-002248-92pzqj35	262	20	the	the	DT
cord-002248-92pzqj35	262	21	ability	ability	NN
cord-002248-92pzqj35	262	22	to	to	TO
cord-002248-92pzqj35	262	23	promote	promote	VB
cord-002248-92pzqj35	262	24	the	the	DT
cord-002248-92pzqj35	262	25	degradation	degradation	NN
cord-002248-92pzqj35	262	26	of	of	IN
cord-002248-92pzqj35	262	27	p62	p62	NN
cord-002248-92pzqj35	262	28	.	.	.
cord-002248-92pzqj35	263	1	Unexpectedly	unexpectedly	RB
cord-002248-92pzqj35	263	2	,	,	,
cord-002248-92pzqj35	263	3	NSs	NSs	NNP
cord-002248-92pzqj35	263	4	-	-	:
cord-002248-92pzqj35	263	5	R16H/	R16H/	NNP
cord-002248-92pzqj35	263	6	M250	M250	NNP
cord-002248-92pzqj35	263	7	K	K	NNP
cord-002248-92pzqj35	263	8	was	be	VBD
cord-002248-92pzqj35	263	9	able	able	JJ
cord-002248-92pzqj35	263	10	to	to	TO
cord-002248-92pzqj35	263	11	interact	interact	VB
cord-002248-92pzqj35	263	12	with	with	IN
cord-002248-92pzqj35	263	13	FBOX3	FBOX3	NNP
cord-002248-92pzqj35	263	14	and	and	CC
cord-002248-92pzqj35	263	15	p62	p62	NN
cord-002248-92pzqj35	263	16	(	(	-LRB-
cord-002248-92pzqj35	263	17	Fig	Fig	NNP
cord-002248-92pzqj35	263	18	6	6	CD
cord-002248-92pzqj35	263	19	)	)	-RRB-
cord-002248-92pzqj35	263	20	.	.	.
cord-002248-92pzqj35	264	1	These	these	DT
cord-002248-92pzqj35	264	2	data	datum	NNS
cord-002248-92pzqj35	264	3	possibly	possibly	RB
cord-002248-92pzqj35	264	4	suggest	suggest	VBP
cord-002248-92pzqj35	264	5	that	that	IN
cord-002248-92pzqj35	264	6	the	the	DT
cord-002248-92pzqj35	264	7	FBXO3-NSs	fbxo3-nss	JJ
cord-002248-92pzqj35	264	8	-	-	HYPH
cord-002248-92pzqj35	264	9	p62	p62	NN
cord-002248-92pzqj35	264	10	interaction	interaction	NN
cord-002248-92pzqj35	264	11	may	may	MD
cord-002248-92pzqj35	264	12	not	not	RB
cord-002248-92pzqj35	264	13	be	be	VB
cord-002248-92pzqj35	264	14	sufficient	sufficient	JJ
cord-002248-92pzqj35	264	15	to	to	TO
cord-002248-92pzqj35	264	16	trigger	trigger	VB
cord-002248-92pzqj35	264	17	p62	p62	NN
cord-002248-92pzqj35	264	18	degradation	degradation	NN
cord-002248-92pzqj35	264	19	.	.	.
cord-002248-92pzqj35	265	1	NSs	NSs	NNP
cord-002248-92pzqj35	265	2	-	-	:
cord-002248-92pzqj35	265	3	M250	M250	NNP
cord-002248-92pzqj35	265	4	K	K	NNP
cord-002248-92pzqj35	265	5	exhibited	exhibit	VBD
cord-002248-92pzqj35	265	6	a	a	DT
cord-002248-92pzqj35	265	7	partially	partially	RB
cord-002248-92pzqj35	265	8	reduced	reduce	VBN
cord-002248-92pzqj35	265	9	activity	activity	NN
cord-002248-92pzqj35	265	10	to	to	TO
cord-002248-92pzqj35	265	11	inhibit	inhibit	VB
cord-002248-92pzqj35	265	12	general	general	JJ
cord-002248-92pzqj35	265	13	transcription	transcription	NN
cord-002248-92pzqj35	265	14	.	.	.
cord-002248-92pzqj35	266	1	The	the	DT
cord-002248-92pzqj35	266	2	results	result	NNS
cord-002248-92pzqj35	266	3	of	of	IN
cord-002248-92pzqj35	266	4	co	co	JJ
cord-002248-92pzqj35	266	5	-	-	JJ
cord-002248-92pzqj35	266	6	immunoprecipitation	immunoprecipitation	JJ
cord-002248-92pzqj35	266	7	assays	assay	NNS
cord-002248-92pzqj35	266	8	showed	show	VBD
cord-002248-92pzqj35	266	9	that	that	IN
cord-002248-92pzqj35	266	10	a	a	DT
cord-002248-92pzqj35	266	11	reduced	reduce	VBN
cord-002248-92pzqj35	266	12	amount	amount	NN
cord-002248-92pzqj35	266	13	of	of	IN
cord-002248-92pzqj35	266	14	NSs	nss	NN
cord-002248-92pzqj35	266	15	-	-	:
cord-002248-92pzqj35	266	16	M250	M250	NNP
cord-002248-92pzqj35	266	17	K	K	NNP
cord-002248-92pzqj35	266	18	co	co	NN
cord-002248-92pzqj35	266	19	-	-	VBD
cord-002248-92pzqj35	266	20	precipitated	precipitate	VBN
cord-002248-92pzqj35	266	21	with	with	IN
cord-002248-92pzqj35	266	22	SAP30	SAP30	NNP
cord-002248-92pzqj35	266	23	,	,	,
cord-002248-92pzqj35	266	24	p62	p62	NN
cord-002248-92pzqj35	266	25	and	and	CC
cord-002248-92pzqj35	266	26	p44	p44	NN
cord-002248-92pzqj35	266	27	,	,	,
cord-002248-92pzqj35	266	28	compared	compare	VBN
cord-002248-92pzqj35	266	29	with	with	IN
cord-002248-92pzqj35	266	30	that	that	DT
cord-002248-92pzqj35	266	31	in	in	IN
cord-002248-92pzqj35	266	32	wt	wt	NN
cord-002248-92pzqj35	266	33	NSs	NSs	NNP
cord-002248-92pzqj35	266	34	(	(	-LRB-
cord-002248-92pzqj35	266	35	Figs	Figs	NNP
cord-002248-92pzqj35	266	36	5	5	CD
cord-002248-92pzqj35	266	37	and	and	CC
cord-002248-92pzqj35	266	38	6	6	CD
cord-002248-92pzqj35	266	39	)	)	-RRB-
cord-002248-92pzqj35	266	40	.	.	.
cord-002248-92pzqj35	267	1	However	however	RB
cord-002248-92pzqj35	267	2	,	,	,
cord-002248-92pzqj35	267	3	the	the	DT
cord-002248-92pzqj35	267	4	slightly	slightly	RB
cord-002248-92pzqj35	267	5	impaired	impaired	JJ
cord-002248-92pzqj35	267	6	ability	ability	NN
cord-002248-92pzqj35	267	7	of	of	IN
cord-002248-92pzqj35	267	8	NSs	NSs	NNP
cord-002248-92pzqj35	267	9	-	-	:
cord-002248-92pzqj35	267	10	M250	M250	NNP
cord-002248-92pzqj35	267	11	K	K	NNP
cord-002248-92pzqj35	267	12	to	to	TO
cord-002248-92pzqj35	267	13	inhibit	inhibit	VB
cord-002248-92pzqj35	267	14	general	general	JJ
cord-002248-92pzqj35	267	15	transcription	transcription	NN
cord-002248-92pzqj35	267	16	could	could	MD
cord-002248-92pzqj35	267	17	not	not	RB
cord-002248-92pzqj35	267	18	be	be	VB
cord-002248-92pzqj35	267	19	solely	solely	RB
cord-002248-92pzqj35	267	20	attributed	attribute	VBN
cord-002248-92pzqj35	267	21	to	to	IN
cord-002248-92pzqj35	267	22	the	the	DT
cord-002248-92pzqj35	267	23	lower	lower	RBR
cord-002248-92pzqj35	267	24	binding	binding	JJ
cord-002248-92pzqj35	267	25	efficiency	efficiency	NN
cord-002248-92pzqj35	267	26	of	of	IN
cord-002248-92pzqj35	267	27	NSs	NSs	NNP
cord-002248-92pzqj35	267	28	-	-	:
cord-002248-92pzqj35	267	29	M250	M250	NNP
cord-002248-92pzqj35	267	30	K	K	NNP
cord-002248-92pzqj35	267	31	to	to	IN
cord-002248-92pzqj35	267	32	p44	p44	NN
cord-002248-92pzqj35	267	33	because	because	IN
cord-002248-92pzqj35	267	34	NSs	NSs	NNP
cord-002248-92pzqj35	267	35	-	-	:
cord-002248-92pzqj35	267	36	M250	M250	NNP
cord-002248-92pzqj35	267	37	K	K	NNP
cord-002248-92pzqj35	267	38	efficiently	efficiently	RB
cord-002248-92pzqj35	267	39	suppressed	suppress	VBD
cord-002248-92pzqj35	267	40	IFN	IFN	NNP
cord-002248-92pzqj35	267	41	-	-	HYPH
cord-002248-92pzqj35	267	42	β	β	NN
cord-002248-92pzqj35	267	43	transcription	transcription	NN
cord-002248-92pzqj35	267	44	and	and	CC
cord-002248-92pzqj35	267	45	induced	induce	VBN
cord-002248-92pzqj35	267	46	p62	p62	NN
cord-002248-92pzqj35	267	47	degradation	degradation	NN
cord-002248-92pzqj35	267	48	,	,	,
cord-002248-92pzqj35	267	49	despite	despite	IN
cord-002248-92pzqj35	267	50	its	-PRON-	PRP$
cord-002248-92pzqj35	267	51	lower	low	JJR
cord-002248-92pzqj35	267	52	efficiency	efficiency	NN
cord-002248-92pzqj35	267	53	of	of	IN
cord-002248-92pzqj35	267	54	binding	bind	VBG
cord-002248-92pzqj35	267	55	to	to	IN
cord-002248-92pzqj35	267	56	SAP30	SAP30	NNP
cord-002248-92pzqj35	267	57	and	and	CC
cord-002248-92pzqj35	267	58	p62	p62	NN
cord-002248-92pzqj35	267	59	.	.	.
cord-002248-92pzqj35	268	1	Moreover	moreover	RB
cord-002248-92pzqj35	268	2	,	,	,
cord-002248-92pzqj35	268	3	NSs	nss	NN
cord-002248-92pzqj35	268	4	-	-	HYPH
cord-002248-92pzqj35	268	5	R16H	R16H	NNP
cord-002248-92pzqj35	268	6	/	/	SYM
cord-002248-92pzqj35	268	7	M250	M250	NNP
cord-002248-92pzqj35	268	8	K	K	NNP
cord-002248-92pzqj35	268	9	,	,	,
cord-002248-92pzqj35	268	10	which	which	WDT
cord-002248-92pzqj35	268	11	lacked	lack	VBD
cord-002248-92pzqj35	268	12	transcription	transcription	NN
cord-002248-92pzqj35	268	13	suppression	suppression	NN
cord-002248-92pzqj35	268	14	activity	activity	NN
cord-002248-92pzqj35	268	15	,	,	,
cord-002248-92pzqj35	268	16	efficiently	efficiently	RB
cord-002248-92pzqj35	268	17	interacted	interact	VBD
cord-002248-92pzqj35	268	18	with	with	IN
cord-002248-92pzqj35	268	19	p44	p44	NN
cord-002248-92pzqj35	268	20	(	(	-LRB-
cord-002248-92pzqj35	268	21	Fig	Fig	NNP
cord-002248-92pzqj35	268	22	6	6	CD
cord-002248-92pzqj35	268	23	)	)	-RRB-
cord-002248-92pzqj35	268	24	.	.	.
cord-002248-92pzqj35	269	1	These	these	DT
cord-002248-92pzqj35	269	2	data	datum	NNS
cord-002248-92pzqj35	269	3	bring	bring	VBP
cord-002248-92pzqj35	269	4	into	into	IN
cord-002248-92pzqj35	269	5	question	question	NN
cord-002248-92pzqj35	269	6	the	the	DT
cord-002248-92pzqj35	269	7	importance	importance	NN
cord-002248-92pzqj35	269	8	of	of	IN
cord-002248-92pzqj35	269	9	NSs	NSs	NNP
cord-002248-92pzqj35	269	10	-	-	HYPH
cord-002248-92pzqj35	269	11	p44	p44	NN
cord-002248-92pzqj35	269	12	interaction	interaction	NN
cord-002248-92pzqj35	269	13	for	for	IN
cord-002248-92pzqj35	269	14	its	-PRON-	PRP$
cord-002248-92pzqj35	269	15	host	host	NN
cord-002248-92pzqj35	269	16	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	269	17	shut	shut	NN
cord-002248-92pzqj35	269	18	-	-	HYPH
cord-002248-92pzqj35	269	19	off	off	RP
cord-002248-92pzqj35	269	20	function	function	NN
cord-002248-92pzqj35	269	21	.	.	.
cord-002248-92pzqj35	270	1	One	one	CD
cord-002248-92pzqj35	270	2	possibility	possibility	NN
cord-002248-92pzqj35	270	3	is	be	VBZ
cord-002248-92pzqj35	270	4	that	that	IN
cord-002248-92pzqj35	270	5	the	the	DT
cord-002248-92pzqj35	270	6	NSs	NSs	NNP
cord-002248-92pzqj35	270	7	-	-	HYPH
cord-002248-92pzqj35	270	8	p44	p44	NN
cord-002248-92pzqj35	270	9	interaction	interaction	NN
cord-002248-92pzqj35	270	10	may	may	MD
cord-002248-92pzqj35	270	11	only	only	RB
cord-002248-92pzqj35	270	12	make	make	VB
cord-002248-92pzqj35	270	13	a	a	DT
cord-002248-92pzqj35	270	14	modest	modest	JJ
cord-002248-92pzqj35	270	15	contribution	contribution	NN
cord-002248-92pzqj35	270	16	towards	towards	IN
cord-002248-92pzqj35	270	17	its	-PRON-	PRP$
cord-002248-92pzqj35	270	18	transcription	transcription	NN
cord-002248-92pzqj35	270	19	inhibition	inhibition	NN
cord-002248-92pzqj35	270	20	activity	activity	NN
cord-002248-92pzqj35	270	21	and	and	CC
cord-002248-92pzqj35	270	22	possibly	possibly	RB
cord-002248-92pzqj35	270	23	could	could	MD
cord-002248-92pzqj35	270	24	have	have	VB
cord-002248-92pzqj35	270	25	additional	additional	JJ
cord-002248-92pzqj35	270	26	,	,	,
cord-002248-92pzqj35	270	27	as	as	RB
cord-002248-92pzqj35	270	28	yet	yet	RB
cord-002248-92pzqj35	270	29	unidentified	unidentified	JJ
cord-002248-92pzqj35	270	30	,	,	,
cord-002248-92pzqj35	270	31	biological	biological	JJ
cord-002248-92pzqj35	270	32	function(s	function(s	NNP
cord-002248-92pzqj35	270	33	)	)	-RRB-
cord-002248-92pzqj35	270	34	.	.	.
cord-002248-92pzqj35	271	1	A	a	DT
cord-002248-92pzqj35	271	2	second	second	JJ
cord-002248-92pzqj35	271	3	possibility	possibility	NN
cord-002248-92pzqj35	271	4	is	be	VBZ
cord-002248-92pzqj35	271	5	that	that	IN
cord-002248-92pzqj35	271	6	only	only	RB
cord-002248-92pzqj35	271	7	wt	wt	NN
cord-002248-92pzqj35	271	8	NSs	NSs	NNP
cord-002248-92pzqj35	271	9	,	,	,
cord-002248-92pzqj35	271	10	but	but	CC
cord-002248-92pzqj35	271	11	not	not	RB
cord-002248-92pzqj35	271	12	the	the	DT
cord-002248-92pzqj35	271	13	mutated	mutated	JJ
cord-002248-92pzqj35	271	14	NSs	NSs	NNP
cord-002248-92pzqj35	271	15	,	,	,
cord-002248-92pzqj35	271	16	is	be	VBZ
cord-002248-92pzqj35	271	17	able	able	JJ
cord-002248-92pzqj35	271	18	to	to	TO
cord-002248-92pzqj35	271	19	interfere	interfere	VB
cord-002248-92pzqj35	271	20	with	with	IN
cord-002248-92pzqj35	271	21	the	the	DT
cord-002248-92pzqj35	271	22	formation	formation	NN
cord-002248-92pzqj35	271	23	of	of	IN
cord-002248-92pzqj35	271	24	an	an	DT
cord-002248-92pzqj35	271	25	active	active	JJ
cord-002248-92pzqj35	271	26	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	271	27	complex	complex	NN
cord-002248-92pzqj35	271	28	.	.	.
cord-002248-92pzqj35	272	1	NSs	NSs	NNP
cord-002248-92pzqj35	272	2	competes	compete	VBZ
cord-002248-92pzqj35	272	3	with	with	IN
cord-002248-92pzqj35	272	4	XPD	XPD	NNP
cord-002248-92pzqj35	272	5	for	for	IN
cord-002248-92pzqj35	272	6	binding	bind	VBG
cord-002248-92pzqj35	272	7	to	to	IN
cord-002248-92pzqj35	272	8	p44	p44	NN
cord-002248-92pzqj35	272	9	,	,	,
cord-002248-92pzqj35	272	10	resulting	result	VBG
cord-002248-92pzqj35	272	11	in	in	IN
cord-002248-92pzqj35	272	12	inhibition	inhibition	NN
cord-002248-92pzqj35	272	13	of	of	IN
cord-002248-92pzqj35	272	14	the	the	DT
cord-002248-92pzqj35	272	15	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	272	16	complex	complex	JJ
cord-002248-92pzqj35	272	17	formation	formation	NN
cord-002248-92pzqj35	272	18	[	[	-LRB-
cord-002248-92pzqj35	272	19	12	12	CD
cord-002248-92pzqj35	272	20	]	]	-RRB-
cord-002248-92pzqj35	272	21	.	.	.
cord-002248-92pzqj35	273	1	Although	although	IN
cord-002248-92pzqj35	273	2	both	both	DT
cord-002248-92pzqj35	273	3	NSs	ns	NNS
cord-002248-92pzqj35	273	4	-	-	:
cord-002248-92pzqj35	273	5	M250	M250	NNP
cord-002248-92pzqj35	273	6	K	K	NNP
cord-002248-92pzqj35	273	7	and	and	CC
cord-002248-92pzqj35	273	8	NSs	NSs	NNP
cord-002248-92pzqj35	273	9	-	-	HYPH
cord-002248-92pzqj35	273	10	R16H	R16H	NNP
cord-002248-92pzqj35	273	11	/	/	SYM
cord-002248-92pzqj35	273	12	M250	M250	NNP
cord-002248-92pzqj35	273	13	K	K	NNP
cord-002248-92pzqj35	273	14	retained	retain	VBD
cord-002248-92pzqj35	273	15	the	the	DT
cord-002248-92pzqj35	273	16	ability	ability	NN
cord-002248-92pzqj35	273	17	to	to	TO
cord-002248-92pzqj35	273	18	bind	bind	VB
cord-002248-92pzqj35	273	19	to	to	IN
cord-002248-92pzqj35	273	20	p44	p44	NN
cord-002248-92pzqj35	273	21	,	,	,
cord-002248-92pzqj35	273	22	it	-PRON-	PRP
cord-002248-92pzqj35	273	23	is	be	VBZ
cord-002248-92pzqj35	273	24	possible	possible	JJ
cord-002248-92pzqj35	273	25	that	that	IN
cord-002248-92pzqj35	273	26	the	the	DT
cord-002248-92pzqj35	273	27	binding	binding	NN
cord-002248-92pzqj35	273	28	of	of	IN
cord-002248-92pzqj35	273	29	these	these	DT
cord-002248-92pzqj35	273	30	mutated	mutate	VBN
cord-002248-92pzqj35	273	31	NSs	ns	NNS
cord-002248-92pzqj35	273	32	to	to	IN
cord-002248-92pzqj35	273	33	p44	p44	NN
cord-002248-92pzqj35	273	34	did	do	VBD
cord-002248-92pzqj35	273	35	not	not	RB
cord-002248-92pzqj35	273	36	exclude	exclude	VB
cord-002248-92pzqj35	273	37	the	the	DT
cord-002248-92pzqj35	273	38	binding	binding	NN
cord-002248-92pzqj35	273	39	of	of	IN
cord-002248-92pzqj35	273	40	XPD	XPD	NNP
cord-002248-92pzqj35	273	41	.	.	.
cord-002248-92pzqj35	274	1	The	the	DT
cord-002248-92pzqj35	274	2	R16H	r16h	NN
cord-002248-92pzqj35	274	3	single	single	JJ
cord-002248-92pzqj35	274	4	mutation	mutation	NN
cord-002248-92pzqj35	274	5	did	do	VBD
cord-002248-92pzqj35	274	6	not	not	RB
cord-002248-92pzqj35	274	7	affect	affect	VB
cord-002248-92pzqj35	274	8	the	the	DT
cord-002248-92pzqj35	274	9	ability	ability	NN
cord-002248-92pzqj35	274	10	of	of	IN
cord-002248-92pzqj35	274	11	NSs	ns	NNS
cord-002248-92pzqj35	274	12	to	to	TO
cord-002248-92pzqj35	274	13	inhibit	inhibit	VB
cord-002248-92pzqj35	274	14	transcription	transcription	NN
cord-002248-92pzqj35	274	15	(	(	-LRB-
cord-002248-92pzqj35	274	16	Fig	Fig	NNP
cord-002248-92pzqj35	274	17	2	2	CD
cord-002248-92pzqj35	274	18	)	)	-RRB-
cord-002248-92pzqj35	274	19	.	.	.
cord-002248-92pzqj35	275	1	Although	although	IN
cord-002248-92pzqj35	275	2	the	the	DT
cord-002248-92pzqj35	275	3	M250	M250	NNP
cord-002248-92pzqj35	275	4	K	K	NNP
cord-002248-92pzqj35	275	5	mutation	mutation	NN
cord-002248-92pzqj35	275	6	is	be	VBZ
cord-002248-92pzqj35	275	7	in	in	IN
cord-002248-92pzqj35	275	8	close	close	JJ
cord-002248-92pzqj35	275	9	proximity	proximity	NN
cord-002248-92pzqj35	275	10	to	to	IN
cord-002248-92pzqj35	275	11	the	the	DT
cord-002248-92pzqj35	275	12	ΩXaV	ΩXaV	NNP
cord-002248-92pzqj35	275	13	motif	motif	NN
cord-002248-92pzqj35	275	14	located	locate	VBN
cord-002248-92pzqj35	275	15	at	at	IN
cord-002248-92pzqj35	275	16	the	the	DT
cord-002248-92pzqj35	275	17	C	C	NNP
cord-002248-92pzqj35	275	18	-	-	HYPH
cord-002248-92pzqj35	275	19	terminal	terminal	NN
cord-002248-92pzqj35	275	20	region	region	NN
cord-002248-92pzqj35	275	21	of	of	IN
cord-002248-92pzqj35	275	22	NSs	NSs	NNP
cord-002248-92pzqj35	275	23	,	,	,
cord-002248-92pzqj35	275	24	which	which	WDT
cord-002248-92pzqj35	275	25	is	be	VBZ
cord-002248-92pzqj35	275	26	essential	essential	JJ
cord-002248-92pzqj35	275	27	for	for	IN
cord-002248-92pzqj35	275	28	p62	p62	NN
cord-002248-92pzqj35	275	29	degradation	degradation	NN
cord-002248-92pzqj35	275	30	[	[	-LRB-
cord-002248-92pzqj35	275	31	32	32	CD
cord-002248-92pzqj35	275	32	]	]	-RRB-
cord-002248-92pzqj35	275	33	,	,	,
cord-002248-92pzqj35	275	34	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	275	35	K	K	NNP
cord-002248-92pzqj35	275	36	still	still	RB
cord-002248-92pzqj35	275	37	retained	retain	VBD
cord-002248-92pzqj35	275	38	the	the	DT
cord-002248-92pzqj35	275	39	ability	ability	NN
cord-002248-92pzqj35	275	40	to	to	TO
cord-002248-92pzqj35	275	41	degrade	degrade	VB
cord-002248-92pzqj35	275	42	p62	p62	CD
cord-002248-92pzqj35	275	43	(	(	-LRB-
cord-002248-92pzqj35	275	44	Fig	Fig	NNP
cord-002248-92pzqj35	275	45	6	6	CD
cord-002248-92pzqj35	275	46	)	)	-RRB-
cord-002248-92pzqj35	275	47	.	.	.
cord-002248-92pzqj35	276	1	However	however	RB
cord-002248-92pzqj35	276	2	,	,	,
cord-002248-92pzqj35	276	3	the	the	DT
cord-002248-92pzqj35	276	4	R16H	r16h	NN
cord-002248-92pzqj35	276	5	/	/	SYM
cord-002248-92pzqj35	276	6	M250	M250	NNP
cord-002248-92pzqj35	276	7	K	K	NNP
cord-002248-92pzqj35	276	8	double	double	NN
cord-002248-92pzqj35	276	9	mutant	mutant	NN
cord-002248-92pzqj35	276	10	lost	lose	VBD
cord-002248-92pzqj35	276	11	the	the	DT
cord-002248-92pzqj35	276	12	ability	ability	NN
cord-002248-92pzqj35	276	13	to	to	TO
cord-002248-92pzqj35	276	14	induce	induce	VB
cord-002248-92pzqj35	276	15	p62	p62	NN
cord-002248-92pzqj35	276	16	degradation	degradation	NN
cord-002248-92pzqj35	276	17	.	.	.
cord-002248-92pzqj35	277	1	These	these	DT
cord-002248-92pzqj35	277	2	results	result	NNS
cord-002248-92pzqj35	277	3	imply	imply	VBP
cord-002248-92pzqj35	277	4	that	that	IN
cord-002248-92pzqj35	277	5	the	the	DT
cord-002248-92pzqj35	277	6	combined	combined	JJ
cord-002248-92pzqj35	277	7	mutations	mutation	NNS
cord-002248-92pzqj35	277	8	,	,	,
cord-002248-92pzqj35	277	9	R16H	R16H	NNP
cord-002248-92pzqj35	277	10	and	and	CC
cord-002248-92pzqj35	277	11	M250	M250	NNP
cord-002248-92pzqj35	277	12	K	K	NNP
cord-002248-92pzqj35	277	13	,	,	,
cord-002248-92pzqj35	277	14	induced	induce	VBD
cord-002248-92pzqj35	277	15	an	an	DT
cord-002248-92pzqj35	277	16	unfavorable	unfavorable	JJ
cord-002248-92pzqj35	277	17	structural	structural	JJ
cord-002248-92pzqj35	277	18	alteration	alteration	NN
cord-002248-92pzqj35	277	19	in	in	IN
cord-002248-92pzqj35	277	20	NSs	NSs	NNP
cord-002248-92pzqj35	277	21	,	,	,
cord-002248-92pzqj35	277	22	which	which	WDT
cord-002248-92pzqj35	277	23	abolished	abolish	VBD
cord-002248-92pzqj35	277	24	its	-PRON-	PRP$
cord-002248-92pzqj35	277	25	function	function	NN
cord-002248-92pzqj35	277	26	to	to	TO
cord-002248-92pzqj35	277	27	degrade	degrade	VB
cord-002248-92pzqj35	277	28	p62	p62	NN
cord-002248-92pzqj35	277	29	.	.	.
cord-002248-92pzqj35	278	1	MP-12-R16H/	mp-12-r16h/	XX
cord-002248-92pzqj35	279	1	M250	M250	NNP
cord-002248-92pzqj35	279	2	K	K	NNP
cord-002248-92pzqj35	279	3	replication	replication	NN
cord-002248-92pzqj35	279	4	induced	induce	VBN
cord-002248-92pzqj35	279	5	low	low	JJ
cord-002248-92pzqj35	279	6	levels	level	NNS
cord-002248-92pzqj35	279	7	of	of	IN
cord-002248-92pzqj35	279	8	IFN	IFN	NNP
cord-002248-92pzqj35	279	9	-	-	HYPH
cord-002248-92pzqj35	279	10	β	β	NNP
cord-002248-92pzqj35	279	11	mRNA	mrna	NN
cord-002248-92pzqj35	280	1	(	(	-LRB-
cord-002248-92pzqj35	280	2	Fig	Fig	NNP
cord-002248-92pzqj35	280	3	5	5	CD
cord-002248-92pzqj35	280	4	)	)	-RRB-
cord-002248-92pzqj35	280	5	,	,	,
cord-002248-92pzqj35	280	6	indicating	indicate	VBG
cord-002248-92pzqj35	280	7	that	that	IN
cord-002248-92pzqj35	280	8	NSs	nss	NN
cord-002248-92pzqj35	280	9	-	-	HYPH
cord-002248-92pzqj35	280	10	R16H	R16H	NNP
cord-002248-92pzqj35	280	11	/	/	SYM
cord-002248-92pzqj35	280	12	M250	M250	NNP
cord-002248-92pzqj35	280	13	K	K	NNP
cord-002248-92pzqj35	280	14	was	be	VBD
cord-002248-92pzqj35	280	15	not	not	RB
cord-002248-92pzqj35	280	16	able	able	JJ
cord-002248-92pzqj35	280	17	to	to	TO
cord-002248-92pzqj35	280	18	block	block	VB
cord-002248-92pzqj35	280	19	IFN	IFN	NNP
cord-002248-92pzqj35	280	20	-	-	HYPH
cord-002248-92pzqj35	280	21	β	β	NNP
cord-002248-92pzqj35	280	22	mRNA	mrna	NN
cord-002248-92pzqj35	280	23	synthesis	synthesis	NN
cord-002248-92pzqj35	280	24	as	as	RB
cord-002248-92pzqj35	280	25	efficiently	efficiently	RB
cord-002248-92pzqj35	280	26	as	as	IN
cord-002248-92pzqj35	280	27	wt	wt	NN
cord-002248-92pzqj35	280	28	NSs	NSs	NNP
cord-002248-92pzqj35	280	29	despite	despite	IN
cord-002248-92pzqj35	280	30	its	-PRON-	PRP$
cord-002248-92pzqj35	280	31	ability	ability	NN
cord-002248-92pzqj35	280	32	to	to	TO
cord-002248-92pzqj35	280	33	interact	interact	VB
cord-002248-92pzqj35	280	34	with	with	IN
cord-002248-92pzqj35	280	35	SAP30	SAP30	NNP
cord-002248-92pzqj35	280	36	(	(	-LRB-
cord-002248-92pzqj35	280	37	Fig	Fig	NNP
cord-002248-92pzqj35	280	38	5	5	CD
cord-002248-92pzqj35	280	39	)	)	-RRB-
cord-002248-92pzqj35	280	40	.	.	.
cord-002248-92pzqj35	281	1	It	-PRON-	PRP
cord-002248-92pzqj35	281	2	has	have	VBZ
cord-002248-92pzqj35	281	3	been	be	VBN
cord-002248-92pzqj35	281	4	reported	report	VBN
cord-002248-92pzqj35	281	5	that	that	IN
cord-002248-92pzqj35	281	6	NSs	nss	NN
cord-002248-92pzqj35	281	7	-	-	HYPH
cord-002248-92pzqj35	281	8	induced	induce	VBN
cord-002248-92pzqj35	281	9	p62	p62	NN
cord-002248-92pzqj35	281	10	degradation	degradation	NN
cord-002248-92pzqj35	281	11	contributes	contribute	VBZ
cord-002248-92pzqj35	281	12	to	to	IN
cord-002248-92pzqj35	281	13	the	the	DT
cord-002248-92pzqj35	281	14	inhibition	inhibition	NN
cord-002248-92pzqj35	281	15	of	of	IN
cord-002248-92pzqj35	281	16	IFN	IFN	NNP
cord-002248-92pzqj35	281	17	-	-	HYPH
cord-002248-92pzqj35	281	18	β	β	NN
cord-002248-92pzqj35	281	19	production	production	NN
cord-002248-92pzqj35	281	20	[	[	-LRB-
cord-002248-92pzqj35	281	21	14	14	CD
cord-002248-92pzqj35	281	22	]	]	-RRB-
cord-002248-92pzqj35	281	23	.	.	.
cord-002248-92pzqj35	282	1	Accordingly	accordingly	RB
cord-002248-92pzqj35	282	2	,	,	,
cord-002248-92pzqj35	282	3	our	-PRON-	PRP$
cord-002248-92pzqj35	282	4	data	datum	NNS
cord-002248-92pzqj35	282	5	suggested	suggest	VBD
cord-002248-92pzqj35	282	6	that	that	IN
cord-002248-92pzqj35	282	7	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	282	8	/	/	SYM
cord-002248-92pzqj35	282	9	M250	M250	NNP
cord-002248-92pzqj35	282	10	K	K	NNP
cord-002248-92pzqj35	282	11	was	be	VBD
cord-002248-92pzqj35	282	12	unable	unable	JJ
cord-002248-92pzqj35	282	13	to	to	TO
cord-002248-92pzqj35	282	14	completely	completely	RB
cord-002248-92pzqj35	282	15	block	block	VB
cord-002248-92pzqj35	282	16	IFN	IFN	NNP
cord-002248-92pzqj35	282	17	-	-	HYPH
cord-002248-92pzqj35	282	18	β	β	NNP
cord-002248-92pzqj35	283	1	mRNA	mRNA	NNP
cord-002248-92pzqj35	283	2	synthesis	synthesis	NN
cord-002248-92pzqj35	283	3	due	due	IN
cord-002248-92pzqj35	283	4	to	to	IN
cord-002248-92pzqj35	283	5	a	a	DT
cord-002248-92pzqj35	283	6	lack	lack	NN
cord-002248-92pzqj35	283	7	of	of	IN
cord-002248-92pzqj35	283	8	ability	ability	NN
cord-002248-92pzqj35	283	9	to	to	TO
cord-002248-92pzqj35	283	10	promote	promote	VB
cord-002248-92pzqj35	283	11	the	the	DT
cord-002248-92pzqj35	283	12	degradation	degradation	NN
cord-002248-92pzqj35	283	13	of	of	IN
cord-002248-92pzqj35	283	14	p62	p62	NN
cord-002248-92pzqj35	283	15	(	(	-LRB-
cord-002248-92pzqj35	283	16	Fig	Fig	NNP
cord-002248-92pzqj35	283	17	6	6	CD
cord-002248-92pzqj35	283	18	)	)	-RRB-
cord-002248-92pzqj35	283	19	.	.	.
cord-002248-92pzqj35	284	1	Although	although	IN
cord-002248-92pzqj35	284	2	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	284	3	/	/	SYM
cord-002248-92pzqj35	284	4	M250	M250	NNP
cord-002248-92pzqj35	284	5	K	K	NNP
cord-002248-92pzqj35	284	6	replication	replication	NN
cord-002248-92pzqj35	284	7	induced	induce	VBN
cord-002248-92pzqj35	284	8	IFN	IFN	NNP
cord-002248-92pzqj35	284	9	-	-	HYPH
cord-002248-92pzqj35	284	10	β	β	NNP
cord-002248-92pzqj35	284	11	mRNA	mRNA	NNP
cord-002248-92pzqj35	284	12	synthesis	synthesis	NN
cord-002248-92pzqj35	284	13	,	,	,
cord-002248-92pzqj35	284	14	the	the	DT
cord-002248-92pzqj35	284	15	level	level	NN
cord-002248-92pzqj35	284	16	of	of	IN
cord-002248-92pzqj35	284	17	the	the	DT
cord-002248-92pzqj35	284	18	IFN	IFN	NNP
cord-002248-92pzqj35	284	19	-	-	HYPH
cord-002248-92pzqj35	284	20	β	β	NNP
cord-002248-92pzqj35	284	21	mRNA	mrna	NN
cord-002248-92pzqj35	284	22	was	be	VBD
cord-002248-92pzqj35	284	23	significantly	significantly	RB
cord-002248-92pzqj35	284	24	lower	low	JJR
cord-002248-92pzqj35	284	25	than	than	IN
cord-002248-92pzqj35	284	26	that	that	DT
cord-002248-92pzqj35	284	27	in	in	IN
cord-002248-92pzqj35	284	28	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	284	29	-	-	HYPH
cord-002248-92pzqj35	284	30	infected	infect	VBN
cord-002248-92pzqj35	284	31	cells	cell	NNS
cord-002248-92pzqj35	284	32	(	(	-LRB-
cord-002248-92pzqj35	284	33	Fig	Fig	NNP
cord-002248-92pzqj35	284	34	5	5	CD
cord-002248-92pzqj35	284	35	)	)	-RRB-
cord-002248-92pzqj35	284	36	,	,	,
cord-002248-92pzqj35	284	37	suggesting	suggest	VBG
cord-002248-92pzqj35	284	38	the	the	DT
cord-002248-92pzqj35	284	39	importance	importance	NN
cord-002248-92pzqj35	284	40	of	of	IN
cord-002248-92pzqj35	284	41	interaction	interaction	NN
cord-002248-92pzqj35	284	42	of	of	IN
cord-002248-92pzqj35	284	43	NSs	NSs	NNP
cord-002248-92pzqj35	284	44	with	with	IN
cord-002248-92pzqj35	284	45	SAP30	SAP30	NNP
cord-002248-92pzqj35	284	46	for	for	IN
cord-002248-92pzqj35	284	47	IFN	IFN	NNP
cord-002248-92pzqj35	284	48	-	-	HYPH
cord-002248-92pzqj35	284	49	β	β	NNP
cord-002248-92pzqj35	284	50	inhibition	inhibition	NN
cord-002248-92pzqj35	284	51	.	.	.
cord-002248-92pzqj35	285	1	Taken	take	VBN
cord-002248-92pzqj35	285	2	together	together	RB
cord-002248-92pzqj35	285	3	,	,	,
cord-002248-92pzqj35	285	4	the	the	DT
cord-002248-92pzqj35	285	5	data	datum	NNS
cord-002248-92pzqj35	285	6	shown	show	VBN
cord-002248-92pzqj35	285	7	here	here	RB
cord-002248-92pzqj35	285	8	and	and	CC
cord-002248-92pzqj35	285	9	those	those	DT
cord-002248-92pzqj35	285	10	of	of	IN
cord-002248-92pzqj35	285	11	others	other	NNS
cord-002248-92pzqj35	285	12	[	[	-LRB-
cord-002248-92pzqj35	285	13	11	11	CD
cord-002248-92pzqj35	285	14	,	,	,
cord-002248-92pzqj35	285	15	14	14	CD
cord-002248-92pzqj35	285	16	]	]	-RRB-
cord-002248-92pzqj35	285	17	strongly	strongly	RB
cord-002248-92pzqj35	285	18	imply	imply	VBP
cord-002248-92pzqj35	285	19	that	that	IN
cord-002248-92pzqj35	285	20	NSs	NSs	NNP
cord-002248-92pzqj35	285	21	-	-	HYPH
cord-002248-92pzqj35	285	22	SAP30	SAP30	NNP
cord-002248-92pzqj35	285	23	interaction	interaction	NN
cord-002248-92pzqj35	285	24	and	and	CC
cord-002248-92pzqj35	285	25	NSs	nss	NN
cord-002248-92pzqj35	285	26	-	-	HYPH
cord-002248-92pzqj35	285	27	induced	induce	VBN
cord-002248-92pzqj35	285	28	general	general	JJ
cord-002248-92pzqj35	285	29	host	host	NN
cord-002248-92pzqj35	285	30	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	285	31	suppression	suppression	NN
cord-002248-92pzqj35	285	32	function	function	NN
cord-002248-92pzqj35	285	33	are	be	VBP
cord-002248-92pzqj35	285	34	both	both	DT
cord-002248-92pzqj35	285	35	necessary	necessary	JJ
cord-002248-92pzqj35	285	36	for	for	IN
cord-002248-92pzqj35	285	37	efficient	efficient	JJ
cord-002248-92pzqj35	285	38	inhibition	inhibition	NN
cord-002248-92pzqj35	285	39	of	of	IN
cord-002248-92pzqj35	285	40	IFN	IFN	NNP
cord-002248-92pzqj35	285	41	-	-	HYPH
cord-002248-92pzqj35	285	42	β	β	NNP
cord-002248-92pzqj35	285	43	mRNA	mrna	NN
cord-002248-92pzqj35	285	44	transcription	transcription	NN
cord-002248-92pzqj35	285	45	.	.	.
cord-002248-92pzqj35	286	1	MP-12ΔNSs	mp-12δnss	JJ
cord-002248-92pzqj35	286	2	or	or	CC
cord-002248-92pzqj35	286	3	MP-12	MP-12	NNP
cord-002248-92pzqj35	286	4	encoding	encode	VBG
cord-002248-92pzqj35	286	5	a	a	DT
cord-002248-92pzqj35	286	6	reporter	reporter	NN
cord-002248-92pzqj35	286	7	gene	gene	NN
cord-002248-92pzqj35	286	8	in	in	IN
cord-002248-92pzqj35	286	9	place	place	NN
cord-002248-92pzqj35	286	10	of	of	IN
cord-002248-92pzqj35	286	11	the	the	DT
cord-002248-92pzqj35	286	12	NSs	NSs	NNP
cord-002248-92pzqj35	286	13	gene	gene	NN
cord-002248-92pzqj35	286	14	causes	cause	VBZ
cord-002248-92pzqj35	286	15	less	less	RBR
cord-002248-92pzqj35	286	16	prominent	prominent	JJ
cord-002248-92pzqj35	286	17	cytopathic	cytopathic	JJ
cord-002248-92pzqj35	286	18	effects	effect	NNS
cord-002248-92pzqj35	286	19	than	than	IN
cord-002248-92pzqj35	286	20	does	do	VBZ
cord-002248-92pzqj35	286	21	MP-12	MP-12	NNP
cord-002248-92pzqj35	286	22	,	,	,
cord-002248-92pzqj35	286	23	demonstrating	demonstrate	VBG
cord-002248-92pzqj35	286	24	the	the	DT
cord-002248-92pzqj35	286	25	contribution	contribution	NN
cord-002248-92pzqj35	286	26	of	of	IN
cord-002248-92pzqj35	286	27	the	the	DT
cord-002248-92pzqj35	286	28	NSs	NSs	NNP
cord-002248-92pzqj35	286	29	towards	towards	IN
cord-002248-92pzqj35	286	30	the	the	DT
cord-002248-92pzqj35	286	31	induction	induction	NN
cord-002248-92pzqj35	286	32	of	of	IN
cord-002248-92pzqj35	286	33	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	286	34	[	[	-LRB-
cord-002248-92pzqj35	286	35	24	24	CD
cord-002248-92pzqj35	286	36	]	]	-RRB-
cord-002248-92pzqj35	286	37	.	.	.
cord-002248-92pzqj35	287	1	MP-12	MP-12	NNP
cord-002248-92pzqj35	287	2	replication	replication	NN
cord-002248-92pzqj35	287	3	induces	induce	VBZ
cord-002248-92pzqj35	287	4	NSs	nss	NN
cord-002248-92pzqj35	287	5	-	-	HYPH
cord-002248-92pzqj35	287	6	dependent	dependent	JJ
cord-002248-92pzqj35	287	7	p53	p53	NN
cord-002248-92pzqj35	287	8	stabilization	stabilization	NN
cord-002248-92pzqj35	287	9	,	,	,
cord-002248-92pzqj35	287	10	which	which	WDT
cord-002248-92pzqj35	287	11	contributes	contribute	VBZ
cord-002248-92pzqj35	287	12	to	to	IN
cord-002248-92pzqj35	287	13	virus	virus	NN
cord-002248-92pzqj35	287	14	-	-	HYPH
cord-002248-92pzqj35	287	15	induced	induce	VBN
cord-002248-92pzqj35	287	16	cell	cell	NN
cord-002248-92pzqj35	287	17	death	death	NN
cord-002248-92pzqj35	287	18	[	[	-LRB-
cord-002248-92pzqj35	287	19	21	21	CD
cord-002248-92pzqj35	287	20	]	]	-RRB-
cord-002248-92pzqj35	287	21	,	,	,
cord-002248-92pzqj35	287	22	and	and	CC
cord-002248-92pzqj35	287	23	yet	yet	RB
cord-002248-92pzqj35	287	24	it	-PRON-	PRP
cord-002248-92pzqj35	287	25	was	be	VBD
cord-002248-92pzqj35	287	26	unclear	unclear	JJ
cord-002248-92pzqj35	287	27	which	which	WDT
cord-002248-92pzqj35	287	28	function	function	NN
cord-002248-92pzqj35	287	29	of	of	IN
cord-002248-92pzqj35	287	30	the	the	DT
cord-002248-92pzqj35	287	31	NSs	NSs	NNP
cord-002248-92pzqj35	287	32	contributed	contribute	VBD
cord-002248-92pzqj35	287	33	to	to	IN
cord-002248-92pzqj35	287	34	the	the	DT
cord-002248-92pzqj35	287	35	induction	induction	NN
cord-002248-92pzqj35	287	36	of	of	IN
cord-002248-92pzqj35	287	37	the	the	DT
cord-002248-92pzqj35	287	38	p53-mediated	p53-mediated	JJ
cord-002248-92pzqj35	287	39	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	287	40	.	.	.
cord-002248-92pzqj35	288	1	As	as	IN
cord-002248-92pzqj35	288	2	shown	show	VBN
cord-002248-92pzqj35	288	3	in	in	IN
cord-002248-92pzqj35	288	4	Fig	Fig	NNP
cord-002248-92pzqj35	288	5	3	3	CD
cord-002248-92pzqj35	288	6	,	,	,
cord-002248-92pzqj35	288	7	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	288	8	cells	cell	NNS
cord-002248-92pzqj35	288	9	showed	show	VBD
cord-002248-92pzqj35	288	10	the	the	DT
cord-002248-92pzqj35	288	11	lowest	low	JJS
cord-002248-92pzqj35	288	12	cell	cell	NN
cord-002248-92pzqj35	288	13	viability	viability	NN
cord-002248-92pzqj35	288	14	,	,	,
cord-002248-92pzqj35	288	15	followed	follow	VBN
cord-002248-92pzqj35	288	16	in	in	IN
cord-002248-92pzqj35	288	17	order	order	NN
cord-002248-92pzqj35	288	18	by	by	IN
cord-002248-92pzqj35	288	19	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	288	20	K	K	NNP
cord-002248-92pzqj35	288	21	,	,	,
cord-002248-92pzqj35	288	22	which	which	WDT
cord-002248-92pzqj35	288	23	moderately	moderately	RB
cord-002248-92pzqj35	288	24	suppressed	suppress	VBD
cord-002248-92pzqj35	288	25	host	host	NN
cord-002248-92pzqj35	288	26	general	general	JJ
cord-002248-92pzqj35	288	27	transcription	transcription	NN
cord-002248-92pzqj35	288	28	,	,	,
cord-002248-92pzqj35	288	29	and	and	CC
cord-002248-92pzqj35	288	30	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	288	31	/	/	SYM
cord-002248-92pzqj35	288	32	M250	M250	NNP
cord-002248-92pzqj35	288	33	K	K	NNP
cord-002248-92pzqj35	288	34	,	,	,
cord-002248-92pzqj35	288	35	which	which	WDT
cord-002248-92pzqj35	288	36	did	do	VBD
cord-002248-92pzqj35	288	37	not	not	RB
cord-002248-92pzqj35	288	38	suppress	suppress	VB
cord-002248-92pzqj35	288	39	host	host	NN
cord-002248-92pzqj35	288	40	transcription	transcription	NN
cord-002248-92pzqj35	288	41	.	.	.
cord-002248-92pzqj35	289	1	Hence	hence	RB
cord-002248-92pzqj35	289	2	,	,	,
cord-002248-92pzqj35	289	3	there	there	EX
cord-002248-92pzqj35	289	4	was	be	VBD
cord-002248-92pzqj35	289	5	a	a	DT
cord-002248-92pzqj35	289	6	correlation	correlation	NN
cord-002248-92pzqj35	289	7	between	between	IN
cord-002248-92pzqj35	289	8	the	the	DT
cord-002248-92pzqj35	289	9	strength	strength	NN
cord-002248-92pzqj35	289	10	of	of	IN
cord-002248-92pzqj35	289	11	NSs	nss	NN
cord-002248-92pzqj35	289	12	-	-	HYPH
cord-002248-92pzqj35	289	13	mediated	mediate	VBN
cord-002248-92pzqj35	289	14	,	,	,
cord-002248-92pzqj35	289	15	host	host	NN
cord-002248-92pzqj35	289	16	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	289	17	shut	shut	NN
cord-002248-92pzqj35	289	18	-	-	HYPH
cord-002248-92pzqj35	289	19	off	off	RP
cord-002248-92pzqj35	289	20	activity	activity	NN
cord-002248-92pzqj35	289	21	and	and	CC
cord-002248-92pzqj35	289	22	cell	cell	NN
cord-002248-92pzqj35	289	23	viability	viability	NN
cord-002248-92pzqj35	289	24	in	in	IN
cord-002248-92pzqj35	289	25	the	the	DT
cord-002248-92pzqj35	289	26	infected	infected	JJ
cord-002248-92pzqj35	289	27	cells	cell	NNS
cord-002248-92pzqj35	289	28	(	(	-LRB-
cord-002248-92pzqj35	289	29	Table	Table	NNP
cord-002248-92pzqj35	289	30	3	3	CD
cord-002248-92pzqj35	289	31	)	)	-RRB-
cord-002248-92pzqj35	289	32	.	.	.
cord-002248-92pzqj35	290	1	Likewise	likewise	RB
cord-002248-92pzqj35	290	2	,	,	,
cord-002248-92pzqj35	290	3	accumulation	accumulation	NN
cord-002248-92pzqj35	290	4	of	of	IN
cord-002248-92pzqj35	290	5	p53	p53	NN
cord-002248-92pzqj35	290	6	was	be	VBD
cord-002248-92pzqj35	290	7	the	the	DT
cord-002248-92pzqj35	290	8	highest	high	JJS
cord-002248-92pzqj35	290	9	in	in	IN
cord-002248-92pzqj35	290	10	MP-12-infected	mp-12-infected	JJ
cord-002248-92pzqj35	290	11	cells	cell	NNS
cord-002248-92pzqj35	290	12	,	,	,
cord-002248-92pzqj35	290	13	followed	follow	VBN
cord-002248-92pzqj35	290	14	in	in	IN
cord-002248-92pzqj35	290	15	order	order	NN
cord-002248-92pzqj35	290	16	by	by	IN
cord-002248-92pzqj35	290	17	that	that	DT
cord-002248-92pzqj35	290	18	in	in	IN
cord-002248-92pzqj35	290	19	MP-12-M250K	MP-12-M250K	NNP
cord-002248-92pzqj35	290	20	-	-	HYPH
cord-002248-92pzqj35	290	21	infected	infect	VBN
cord-002248-92pzqj35	290	22	cells	cell	NNS
cord-002248-92pzqj35	290	23	and	and	CC
cord-002248-92pzqj35	290	24	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	290	25	/	/	SYM
cord-002248-92pzqj35	290	26	M250K	m250k	NN
cord-002248-92pzqj35	290	27	-	-	HYPH
cord-002248-92pzqj35	290	28	infected	infect	VBN
cord-002248-92pzqj35	290	29	cells	cell	NNS
cord-002248-92pzqj35	290	30	,	,	,
cord-002248-92pzqj35	290	31	suggesting	suggest	VBG
cord-002248-92pzqj35	290	32	to	to	IN
cord-002248-92pzqj35	290	33	us	-PRON-	PRP
cord-002248-92pzqj35	290	34	that	that	DT
cord-002248-92pzqj35	290	35	p53	p53	NN
cord-002248-92pzqj35	290	36	stabilization	stabilization	NN
cord-002248-92pzqj35	290	37	also	also	RB
cord-002248-92pzqj35	290	38	correlates	correlate	VBZ
cord-002248-92pzqj35	290	39	with	with	IN
cord-002248-92pzqj35	290	40	the	the	DT
cord-002248-92pzqj35	290	41	transcription	transcription	NN
cord-002248-92pzqj35	290	42	inhibition	inhibition	NN
cord-002248-92pzqj35	290	43	activities	activity	NNS
cord-002248-92pzqj35	290	44	of	of	IN
cord-002248-92pzqj35	290	45	the	the	DT
cord-002248-92pzqj35	290	46	different	different	JJ
cord-002248-92pzqj35	290	47	NSs	NSs	NNP
cord-002248-92pzqj35	290	48	mutants	mutant	NNS
cord-002248-92pzqj35	290	49	.	.	.
cord-002248-92pzqj35	291	1	These	these	DT
cord-002248-92pzqj35	291	2	results	result	NNS
cord-002248-92pzqj35	291	3	indicate	indicate	VBP
cord-002248-92pzqj35	291	4	that	that	IN
cord-002248-92pzqj35	291	5	the	the	DT
cord-002248-92pzqj35	291	6	NSs	NSs	NNP
cord-002248-92pzqj35	291	7	-	-	HYPH
cord-002248-92pzqj35	291	8	mediated	mediate	VBN
cord-002248-92pzqj35	291	9	host	host	NN
cord-002248-92pzqj35	291	10	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	291	11	shut	shut	NN
cord-002248-92pzqj35	291	12	-	-	HYPH
cord-002248-92pzqj35	291	13	off	off	RP
cord-002248-92pzqj35	291	14	triggered	trigger	VBN
cord-002248-92pzqj35	291	15	p53	p53	NN
cord-002248-92pzqj35	291	16	stabilization	stabilization	NN
cord-002248-92pzqj35	291	17	,	,	,
cord-002248-92pzqj35	291	18	leading	lead	VBG
cord-002248-92pzqj35	291	19	to	to	IN
cord-002248-92pzqj35	291	20	p53-mediated	p53-mediated	JJ
cord-002248-92pzqj35	291	21	cell	cell	NN
cord-002248-92pzqj35	291	22	death	death	NN
cord-002248-92pzqj35	291	23	.	.	.
cord-002248-92pzqj35	292	1	Although	although	IN
cord-002248-92pzqj35	292	2	MP-12	MP-12	NNP
cord-002248-92pzqj35	292	3	is	be	VBZ
cord-002248-92pzqj35	292	4	an	an	DT
cord-002248-92pzqj35	292	5	attenuated	attenuated	JJ
cord-002248-92pzqj35	292	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	292	7	strain	strain	NN
cord-002248-92pzqj35	292	8	,	,	,
cord-002248-92pzqj35	292	9	55	55	CD
cord-002248-92pzqj35	292	10	%	%	NN
cord-002248-92pzqj35	292	11	of	of	IN
cord-002248-92pzqj35	292	12	18-day	18-day	CD
cord-002248-92pzqj35	292	13	-	-	HYPH
cord-002248-92pzqj35	292	14	old	old	JJ
cord-002248-92pzqj35	292	15	CD1	CD1	NNP
cord-002248-92pzqj35	292	16	mice	mouse	NNS
cord-002248-92pzqj35	292	17	died	die	VBD
cord-002248-92pzqj35	292	18	after	after	IN
cord-002248-92pzqj35	292	19	intraperitoneal	intraperitoneal	JJ
cord-002248-92pzqj35	292	20	inoculation	inoculation	NN
cord-002248-92pzqj35	292	21	with	with	IN
cord-002248-92pzqj35	292	22	10	10	CD
cord-002248-92pzqj35	292	23	4	4	CD
cord-002248-92pzqj35	292	24	PFU	pfu	NN
cord-002248-92pzqj35	292	25	within	within	IN
cord-002248-92pzqj35	292	26	13	13	CD
cord-002248-92pzqj35	292	27	days	day	NNS
cord-002248-92pzqj35	292	28	p.i	p.i	NNP
cord-002248-92pzqj35	292	29	.	.	.
cord-002248-92pzqj35	293	1	(	(	-LRB-
cord-002248-92pzqj35	293	2	Fig	Fig	NNP
cord-002248-92pzqj35	293	3	7	7	CD
cord-002248-92pzqj35	293	4	)	)	-RRB-
cord-002248-92pzqj35	293	5	.	.	.
cord-002248-92pzqj35	294	1	As	as	IN
cord-002248-92pzqj35	294	2	the	the	DT
cord-002248-92pzqj35	294	3	immune	immune	JJ
cord-002248-92pzqj35	294	4	system	system	NN
cord-002248-92pzqj35	294	5	is	be	VBZ
cord-002248-92pzqj35	294	6	not	not	RB
cord-002248-92pzqj35	294	7	yet	yet	RB
cord-002248-92pzqj35	294	8	fully	fully	RB
cord-002248-92pzqj35	294	9	developed	develop	VBN
cord-002248-92pzqj35	294	10	in	in	IN
cord-002248-92pzqj35	294	11	young	young	JJ
cord-002248-92pzqj35	294	12	mice	mouse	NNS
cord-002248-92pzqj35	294	13	,	,	,
cord-002248-92pzqj35	294	14	it	-PRON-	PRP
cord-002248-92pzqj35	294	15	likely	likely	RB
cord-002248-92pzqj35	294	16	failed	fail	VBD
cord-002248-92pzqj35	294	17	to	to	TO
cord-002248-92pzqj35	294	18	prevent	prevent	VB
cord-002248-92pzqj35	294	19	systemic	systemic	JJ
cord-002248-92pzqj35	294	20	infection	infection	NN
cord-002248-92pzqj35	294	21	by	by	IN
cord-002248-92pzqj35	294	22	MP-12	MP-12	NNP
cord-002248-92pzqj35	294	23	.	.	.
cord-002248-92pzqj35	295	1	Consistent	consistent	JJ
cord-002248-92pzqj35	295	2	with	with	IN
cord-002248-92pzqj35	295	3	this	this	DT
cord-002248-92pzqj35	295	4	notion	notion	NN
cord-002248-92pzqj35	295	5	,	,	,
cord-002248-92pzqj35	295	6	intraperitoneal	intraperitoneal	JJ
cord-002248-92pzqj35	295	7	inoculation	inoculation	NN
cord-002248-92pzqj35	295	8	of	of	IN
cord-002248-92pzqj35	295	9	MP-12	MP-12	NNP
cord-002248-92pzqj35	295	10	into	into	IN
cord-002248-92pzqj35	295	11	severe	severe	JJ
cord-002248-92pzqj35	295	12	combined	combine	VBN
cord-002248-92pzqj35	295	13	immune	immune	JJ
cord-002248-92pzqj35	295	14	deficiency	deficiency	NN
cord-002248-92pzqj35	295	15	mice	mouse	NNS
cord-002248-92pzqj35	295	16	also	also	RB
cord-002248-92pzqj35	295	17	caused	cause	VBD
cord-002248-92pzqj35	295	18	100	100	CD
cord-002248-92pzqj35	295	19	%	%	NN
cord-002248-92pzqj35	295	20	mortality	mortality	NN
cord-002248-92pzqj35	295	21	[	[	-LRB-
cord-002248-92pzqj35	295	22	33	33	CD
cord-002248-92pzqj35	295	23	]	]	-RRB-
cord-002248-92pzqj35	295	24	.	.	.
cord-002248-92pzqj35	296	1	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	296	2	/	/	SYM
cord-002248-92pzqj35	296	3	M250	M250	NNP
cord-002248-92pzqj35	296	4	K	K	NNP
cord-002248-92pzqj35	296	5	carrying	carry	VBG
cord-002248-92pzqj35	296	6	NSs	ns	NNS
cord-002248-92pzqj35	296	7	that	that	WDT
cord-002248-92pzqj35	296	8	lacks	lack	VBZ
cord-002248-92pzqj35	296	9	the	the	DT
cord-002248-92pzqj35	296	10	host	host	NN
cord-002248-92pzqj35	296	11	transcription	transcription	NN
cord-002248-92pzqj35	296	12	inhibition	inhibition	NN
cord-002248-92pzqj35	296	13	function	function	NN
cord-002248-92pzqj35	296	14	was	be	VBD
cord-002248-92pzqj35	296	15	completely	completely	RB
cord-002248-92pzqj35	296	16	attenuated	attenuate	VBN
cord-002248-92pzqj35	296	17	in	in	IN
cord-002248-92pzqj35	296	18	18-day	18-day	CD
cord-002248-92pzqj35	296	19	-	-	HYPH
cord-002248-92pzqj35	296	20	old	old	JJ
cord-002248-92pzqj35	296	21	CD1	CD1	NNP
cord-002248-92pzqj35	296	22	mice	mouse	NNS
cord-002248-92pzqj35	296	23	(	(	-LRB-
cord-002248-92pzqj35	296	24	Fig	Fig	NNP
cord-002248-92pzqj35	296	25	7	7	CD
cord-002248-92pzqj35	296	26	)	)	-RRB-
cord-002248-92pzqj35	296	27	.	.	.
cord-002248-92pzqj35	297	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	297	2	K	K	NNP
cord-002248-92pzqj35	297	3	carrying	carry	VBG
cord-002248-92pzqj35	297	4	NSs	ns	NNS
cord-002248-92pzqj35	297	5	with	with	IN
cord-002248-92pzqj35	297	6	an	an	DT
cord-002248-92pzqj35	297	7	impaired	impaired	JJ
cord-002248-92pzqj35	297	8	ability	ability	NN
cord-002248-92pzqj35	297	9	to	to	TO
cord-002248-92pzqj35	297	10	inhibit	inhibit	VB
cord-002248-92pzqj35	297	11	transcription	transcription	NN
cord-002248-92pzqj35	297	12	also	also	RB
cord-002248-92pzqj35	297	13	exhibited	exhibit	VBD
cord-002248-92pzqj35	297	14	reduced	reduced	JJ
cord-002248-92pzqj35	297	15	virulence	virulence	NN
cord-002248-92pzqj35	297	16	when	when	WRB
cord-002248-92pzqj35	297	17	compared	compare	VBN
cord-002248-92pzqj35	297	18	to	to	IN
cord-002248-92pzqj35	297	19	that	that	DT
cord-002248-92pzqj35	297	20	in	in	IN
cord-002248-92pzqj35	297	21	its	-PRON-	PRP$
cord-002248-92pzqj35	297	22	parental	parental	JJ
cord-002248-92pzqj35	297	23	virus	virus	NN
cord-002248-92pzqj35	297	24	MP-12	MP-12	NNP
cord-002248-92pzqj35	297	25	.	.	.
cord-002248-92pzqj35	298	1	These	these	DT
cord-002248-92pzqj35	298	2	data	datum	NNS
cord-002248-92pzqj35	298	3	highlight	highlight	VBP
cord-002248-92pzqj35	298	4	the	the	DT
cord-002248-92pzqj35	298	5	role	role	NN
cord-002248-92pzqj35	298	6	of	of	IN
cord-002248-92pzqj35	298	7	the	the	DT
cord-002248-92pzqj35	298	8	host	host	NN
cord-002248-92pzqj35	298	9	transcription	transcription	NN
cord-002248-92pzqj35	298	10	inhibition	inhibition	NN
cord-002248-92pzqj35	298	11	function	function	NN
cord-002248-92pzqj35	298	12	of	of	IN
cord-002248-92pzqj35	298	13	NSs	ns	NNS
cord-002248-92pzqj35	298	14	in	in	IN
cord-002248-92pzqj35	298	15	RVFV	RVFV	NNP
cord-002248-92pzqj35	298	16	virulence	virulence	NN
cord-002248-92pzqj35	298	17	.	.	.
cord-002248-92pzqj35	299	1	Type	type	NN
cord-002248-92pzqj35	300	1	I	-PRON-	PRP
cord-002248-92pzqj35	300	2	IFN	IFN	NNP
cord-002248-92pzqj35	300	3	has	have	VBZ
cord-002248-92pzqj35	300	4	been	be	VBN
cord-002248-92pzqj35	300	5	shown	show	VBN
cord-002248-92pzqj35	300	6	to	to	TO
cord-002248-92pzqj35	300	7	play	play	VB
cord-002248-92pzqj35	300	8	a	a	DT
cord-002248-92pzqj35	300	9	critical	critical	JJ
cord-002248-92pzqj35	300	10	role	role	NN
cord-002248-92pzqj35	300	11	in	in	IN
cord-002248-92pzqj35	300	12	protecting	protect	VBG
cord-002248-92pzqj35	300	13	the	the	DT
cord-002248-92pzqj35	300	14	host	host	NN
cord-002248-92pzqj35	300	15	from	from	IN
cord-002248-92pzqj35	300	16	RVFV	RVFV	NNP
cord-002248-92pzqj35	300	17	-	-	HYPH
cord-002248-92pzqj35	300	18	induced	induce	VBN
cord-002248-92pzqj35	300	19	disease	disease	NN
cord-002248-92pzqj35	300	20	in	in	IN
cord-002248-92pzqj35	300	21	animal	animal	NN
cord-002248-92pzqj35	300	22	models	model	NNS
cord-002248-92pzqj35	300	23	[	[	-LRB-
cord-002248-92pzqj35	300	24	34	34	CD
cord-002248-92pzqj35	300	25	]	]	-RRB-
cord-002248-92pzqj35	300	26	.	.	.
cord-002248-92pzqj35	301	1	Notably	notably	RB
cord-002248-92pzqj35	301	2	,	,	,
cord-002248-92pzqj35	301	3	both	both	CC
cord-002248-92pzqj35	301	4	the	the	DT
cord-002248-92pzqj35	301	5	NSs	NSs	NNP
cord-002248-92pzqj35	301	6	mutants	mutant	NNS
cord-002248-92pzqj35	301	7	,	,	,
cord-002248-92pzqj35	301	8	carrying	carry	VBG
cord-002248-92pzqj35	301	9	either	either	CC
cord-002248-92pzqj35	301	10	the	the	DT
cord-002248-92pzqj35	301	11	M250	M250	NNP
cord-002248-92pzqj35	301	12	K	K	NNP
cord-002248-92pzqj35	301	13	single	single	JJ
cord-002248-92pzqj35	301	14	mutation	mutation	NN
cord-002248-92pzqj35	301	15	or	or	CC
cord-002248-92pzqj35	301	16	the	the	DT
cord-002248-92pzqj35	301	17	R16H	r16h	NN
cord-002248-92pzqj35	301	18	/	/	SYM
cord-002248-92pzqj35	301	19	M250	M250	NNP
cord-002248-92pzqj35	301	20	K	k	XX
cord-002248-92pzqj35	301	21	double	double	JJ
cord-002248-92pzqj35	301	22	mutation	mutation	NN
cord-002248-92pzqj35	301	23	,	,	,
cord-002248-92pzqj35	301	24	retained	retain	VBD
cord-002248-92pzqj35	301	25	the	the	DT
cord-002248-92pzqj35	301	26	ability	ability	NN
cord-002248-92pzqj35	301	27	to	to	TO
cord-002248-92pzqj35	301	28	bind	bind	VB
cord-002248-92pzqj35	301	29	to	to	IN
cord-002248-92pzqj35	301	30	SAP30	SAP30	NNP
cord-002248-92pzqj35	301	31	,	,	,
cord-002248-92pzqj35	301	32	the	the	DT
cord-002248-92pzqj35	301	33	factor	factor	NN
cord-002248-92pzqj35	301	34	that	that	WDT
cord-002248-92pzqj35	301	35	is	be	VBZ
cord-002248-92pzqj35	301	36	targeted	target	VBN
cord-002248-92pzqj35	301	37	by	by	IN
cord-002248-92pzqj35	301	38	NSs	ns	NNS
cord-002248-92pzqj35	301	39	to	to	TO
cord-002248-92pzqj35	301	40	inhibit	inhibit	VB
cord-002248-92pzqj35	301	41	IFN	IFN	NNP
cord-002248-92pzqj35	301	42	-	-	HYPH
cord-002248-92pzqj35	301	43	β	β	NNP
cord-002248-92pzqj35	301	44	mRNA	mrna	NN
cord-002248-92pzqj35	301	45	transcription	transcription	NN
cord-002248-92pzqj35	301	46	.	.	.
cord-002248-92pzqj35	302	1	However	however	RB
cord-002248-92pzqj35	302	2	,	,	,
cord-002248-92pzqj35	302	3	the	the	DT
cord-002248-92pzqj35	302	4	induction	induction	NN
cord-002248-92pzqj35	302	5	of	of	IN
cord-002248-92pzqj35	302	6	IFN	IFN	NNP
cord-002248-92pzqj35	302	7	-	-	HYPH
cord-002248-92pzqj35	302	8	β	β	NNP
cord-002248-92pzqj35	302	9	mRNA	mRNA	NNP
cord-002248-92pzqj35	302	10	synthesis	synthesis	NN
cord-002248-92pzqj35	302	11	was	be	VBD
cord-002248-92pzqj35	302	12	not	not	RB
cord-002248-92pzqj35	302	13	completely	completely	RB
cord-002248-92pzqj35	302	14	blocked	block	VBN
cord-002248-92pzqj35	302	15	in	in	IN
cord-002248-92pzqj35	302	16	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	302	17	/	/	SYM
cord-002248-92pzqj35	302	18	M250K	M250K	NNP
cord-002248-92pzqj35	302	19	-	-	HYPH
cord-002248-92pzqj35	302	20	infected	infect	VBN
cord-002248-92pzqj35	302	21	MRC-5	MRC-5	NNP
cord-002248-92pzqj35	302	22	cells	cell	NNS
cord-002248-92pzqj35	302	23	,	,	,
cord-002248-92pzqj35	302	24	most	most	RBS
cord-002248-92pzqj35	302	25	probably	probably	RB
cord-002248-92pzqj35	302	26	due	due	JJ
cord-002248-92pzqj35	302	27	to	to	IN
cord-002248-92pzqj35	302	28	the	the	DT
cord-002248-92pzqj35	302	29	lack	lack	NN
cord-002248-92pzqj35	302	30	of	of	IN
cord-002248-92pzqj35	302	31	inhibition	inhibition	NN
cord-002248-92pzqj35	302	32	of	of	IN
cord-002248-92pzqj35	302	33	host	host	NN
cord-002248-92pzqj35	302	34	transcription	transcription	NN
cord-002248-92pzqj35	302	35	in	in	IN
cord-002248-92pzqj35	302	36	these	these	DT
cord-002248-92pzqj35	302	37	cells	cell	NNS
cord-002248-92pzqj35	302	38	expressing	express	VBG
cord-002248-92pzqj35	302	39	the	the	DT
cord-002248-92pzqj35	302	40	mutated	mutate	VBN
cord-002248-92pzqj35	302	41	NSs	ns	NNS
cord-002248-92pzqj35	302	42	.	.	.
cord-002248-92pzqj35	303	1	These	these	DT
cord-002248-92pzqj35	303	2	data	datum	NNS
cord-002248-92pzqj35	303	3	suggest	suggest	VBP
cord-002248-92pzqj35	303	4	the	the	DT
cord-002248-92pzqj35	303	5	possibility	possibility	NN
cord-002248-92pzqj35	303	6	that	that	IN
cord-002248-92pzqj35	303	7	the	the	DT
cord-002248-92pzqj35	303	8	inability	inability	NN
cord-002248-92pzqj35	303	9	of	of	IN
cord-002248-92pzqj35	303	10	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	303	11	/	/	SYM
cord-002248-92pzqj35	303	12	M250	M250	NNP
cord-002248-92pzqj35	303	13	K	K	NNP
cord-002248-92pzqj35	303	14	to	to	TO
cord-002248-92pzqj35	303	15	completely	completely	RB
cord-002248-92pzqj35	303	16	block	block	VB
cord-002248-92pzqj35	303	17	the	the	DT
cord-002248-92pzqj35	303	18	production	production	NN
cord-002248-92pzqj35	303	19	of	of	IN
cord-002248-92pzqj35	303	20	IFN	IFN	NNP
cord-002248-92pzqj35	303	21	-	-	HYPH
cord-002248-92pzqj35	303	22	β	β	NNP
cord-002248-92pzqj35	303	23	in	in	IN
cord-002248-92pzqj35	303	24	infected	infected	JJ
cord-002248-92pzqj35	303	25	mice	mouse	NNS
cord-002248-92pzqj35	303	26	could	could	MD
cord-002248-92pzqj35	303	27	have	have	VB
cord-002248-92pzqj35	303	28	contributed	contribute	VBN
cord-002248-92pzqj35	303	29	towards	towards	IN
cord-002248-92pzqj35	303	30	its	-PRON-	PRP$
cord-002248-92pzqj35	303	31	attenuation	attenuation	NN
cord-002248-92pzqj35	303	32	.	.	.
cord-002248-92pzqj35	304	1	In	in	IN
cord-002248-92pzqj35	304	2	addition	addition	NN
cord-002248-92pzqj35	304	3	,	,	,
cord-002248-92pzqj35	304	4	the	the	DT
cord-002248-92pzqj35	304	5	production	production	NN
cord-002248-92pzqj35	304	6	of	of	IN
cord-002248-92pzqj35	304	7	other	other	JJ
cord-002248-92pzqj35	304	8	antiviral	antiviral	JJ
cord-002248-92pzqj35	304	9	and/or	and/or	CC
cord-002248-92pzqj35	304	10	proinflammatory	proinflammatory	JJ
cord-002248-92pzqj35	304	11	cytokines	cytokine	NNS
cord-002248-92pzqj35	304	12	could	could	MD
cord-002248-92pzqj35	304	13	have	have	VB
cord-002248-92pzqj35	304	14	also	also	RB
cord-002248-92pzqj35	304	15	contributed	contribute	VBN
cord-002248-92pzqj35	304	16	towards	towards	IN
cord-002248-92pzqj35	304	17	the	the	DT
cord-002248-92pzqj35	304	18	attenuated	attenuated	JJ
cord-002248-92pzqj35	304	19	phenotype	phenotype	NN
cord-002248-92pzqj35	304	20	of	of	IN
cord-002248-92pzqj35	304	21	both	both	DT
cord-002248-92pzqj35	304	22	of	of	IN
cord-002248-92pzqj35	304	23	these	these	DT
cord-002248-92pzqj35	304	24	mutant	mutant	JJ
cord-002248-92pzqj35	304	25	viruses	virus	NNS
cord-002248-92pzqj35	304	26	,	,	,
cord-002248-92pzqj35	304	27	carrying	carry	VBG
cord-002248-92pzqj35	304	28	NSs	ns	NNS
cord-002248-92pzqj35	304	29	with	with	IN
cord-002248-92pzqj35	304	30	an	an	DT
cord-002248-92pzqj35	304	31	impaired	impaired	JJ
cord-002248-92pzqj35	304	32	ability	ability	NN
cord-002248-92pzqj35	304	33	to	to	TO
cord-002248-92pzqj35	304	34	block	block	VB
cord-002248-92pzqj35	304	35	host	host	NN
cord-002248-92pzqj35	304	36	transcription	transcription	NN
cord-002248-92pzqj35	304	37	.	.	.
cord-002248-92pzqj35	305	1	It	-PRON-	PRP
cord-002248-92pzqj35	305	2	is	be	VBZ
cord-002248-92pzqj35	305	3	also	also	RB
cord-002248-92pzqj35	305	4	possible	possible	JJ
cord-002248-92pzqj35	305	5	that	that	IN
cord-002248-92pzqj35	305	6	the	the	DT
cord-002248-92pzqj35	305	7	lower	low	JJR
cord-002248-92pzqj35	305	8	levels	level	NNS
cord-002248-92pzqj35	305	9	of	of	IN
cord-002248-92pzqj35	305	10	virus	virus	NN
cord-002248-92pzqj35	305	11	-	-	HYPH
cord-002248-92pzqj35	305	12	induced	induce	VBN
cord-002248-92pzqj35	305	13	cytocidal	cytocidal	NN
cord-002248-92pzqj35	305	14	effects	effect	NNS
cord-002248-92pzqj35	305	15	might	may	MD
cord-002248-92pzqj35	305	16	have	have	VB
cord-002248-92pzqj35	305	17	contributed	contribute	VBN
cord-002248-92pzqj35	305	18	to	to	IN
cord-002248-92pzqj35	305	19	the	the	DT
cord-002248-92pzqj35	305	20	lower	low	JJR
cord-002248-92pzqj35	305	21	virulence	virulence	NN
cord-002248-92pzqj35	305	22	of	of	IN
cord-002248-92pzqj35	305	23	these	these	DT
cord-002248-92pzqj35	305	24	NSs	ns	NNS
cord-002248-92pzqj35	305	25	mutant	mutant	JJ
cord-002248-92pzqj35	305	26	viruses	virus	NNS
cord-002248-92pzqj35	305	27	,	,	,
cord-002248-92pzqj35	305	28	as	as	IN
cord-002248-92pzqj35	305	29	both	both	DT
cord-002248-92pzqj35	305	30	mutant	mutant	JJ
cord-002248-92pzqj35	305	31	viruses	virus	NNS
cord-002248-92pzqj35	305	32	caused	cause	VBD
cord-002248-92pzqj35	305	33	less	less	RBR
cord-002248-92pzqj35	305	34	severe	severe	JJ
cord-002248-92pzqj35	305	35	cytopathic	cytopathic	JJ
cord-002248-92pzqj35	305	36	effects	effect	NNS
cord-002248-92pzqj35	305	37	and	and	CC
cord-002248-92pzqj35	305	38	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	305	39	than	than	IN
cord-002248-92pzqj35	305	40	did	do	VBD
cord-002248-92pzqj35	305	41	MP-12	MP-12	NNP
cord-002248-92pzqj35	305	42	in	in	IN
cord-002248-92pzqj35	305	43	cultured	cultured	JJ
cord-002248-92pzqj35	305	44	cells	cell	NNS
cord-002248-92pzqj35	305	45	(	(	-LRB-
cord-002248-92pzqj35	305	46	Fig	Fig	NNP
cord-002248-92pzqj35	305	47	3	3	CD
cord-002248-92pzqj35	305	48	)	)	-RRB-
cord-002248-92pzqj35	305	49	.	.	.
cord-002248-92pzqj35	306	1	We	-PRON-	PRP
cord-002248-92pzqj35	306	2	believe	believe	VBP
cord-002248-92pzqj35	306	3	that	that	IN
cord-002248-92pzqj35	306	4	experiments	experiment	NNS
cord-002248-92pzqj35	306	5	using	use	VBG
cord-002248-92pzqj35	306	6	RVFV	RVFV	NNP
cord-002248-92pzqj35	306	7	mutants	mutant	NNS
cord-002248-92pzqj35	306	8	,	,	,
cord-002248-92pzqj35	306	9	carrying	carry	VBG
cord-002248-92pzqj35	306	10	the	the	DT
cord-002248-92pzqj35	306	11	M250	M250	NNP
cord-002248-92pzqj35	306	12	K	K	NNP
cord-002248-92pzqj35	306	13	single	single	JJ
cord-002248-92pzqj35	306	14	mutation	mutation	NN
cord-002248-92pzqj35	306	15	and	and	CC
cord-002248-92pzqj35	306	16	the	the	DT
cord-002248-92pzqj35	306	17	R16H	r16h	NN
cord-002248-92pzqj35	306	18	/	/	SYM
cord-002248-92pzqj35	306	19	M250	M250	NNP
cord-002248-92pzqj35	306	20	K	k	XX
cord-002248-92pzqj35	306	21	double	double	JJ
cord-002248-92pzqj35	306	22	mutation	mutation	NN
cord-002248-92pzqj35	306	23	,	,	,
cord-002248-92pzqj35	306	24	in	in	IN
cord-002248-92pzqj35	306	25	animal	animal	NN
cord-002248-92pzqj35	306	26	models	model	NNS
cord-002248-92pzqj35	306	27	would	would	MD
cord-002248-92pzqj35	306	28	yield	yield	VB
cord-002248-92pzqj35	306	29	valuable	valuable	JJ
cord-002248-92pzqj35	306	30	information	information	NN
cord-002248-92pzqj35	306	31	about	about	IN
cord-002248-92pzqj35	306	32	the	the	DT
cord-002248-92pzqj35	306	33	role	role	NN
cord-002248-92pzqj35	306	34	of	of	IN
cord-002248-92pzqj35	306	35	NSs	NSs	NNP
cord-002248-92pzqj35	306	36	-	-	HYPH
cord-002248-92pzqj35	306	37	mediated	mediate	VBN
cord-002248-92pzqj35	306	38	host	host	NN
cord-002248-92pzqj35	306	39	transcription	transcription	NN
cord-002248-92pzqj35	306	40	inhibition	inhibition	NN
cord-002248-92pzqj35	306	41	in	in	IN
cord-002248-92pzqj35	306	42	regulating	regulate	VBG
cord-002248-92pzqj35	306	43	host	host	NN
cord-002248-92pzqj35	306	44	cytokine	cytokine	NN
cord-002248-92pzqj35	306	45	responses	response	NNS
cord-002248-92pzqj35	306	46	and	and	CC
cord-002248-92pzqj35	306	47	its	-PRON-	PRP$
cord-002248-92pzqj35	306	48	impact	impact	NN
cord-002248-92pzqj35	306	49	on	on	IN
cord-002248-92pzqj35	306	50	the	the	DT
cord-002248-92pzqj35	306	51	pathogenesis	pathogenesis	NN
cord-002248-92pzqj35	306	52	of	of	IN
cord-002248-92pzqj35	306	53	RVFV	RVFV	NNP
cord-002248-92pzqj35	306	54	.	.	.
cord-002248-92pzqj35	307	1	MP-12	MP-12	NNP
cord-002248-92pzqj35	307	2	is	be	VBZ
cord-002248-92pzqj35	307	3	an	an	DT
cord-002248-92pzqj35	307	4	attenuated	attenuated	JJ
cord-002248-92pzqj35	307	5	live	live	JJ
cord-002248-92pzqj35	307	6	vaccine	vaccine	NN
cord-002248-92pzqj35	307	7	candidate	candidate	NN
cord-002248-92pzqj35	307	8	,	,	,
cord-002248-92pzqj35	307	9	but	but	CC
cord-002248-92pzqj35	307	10	it	-PRON-	PRP
cord-002248-92pzqj35	307	11	still	still	RB
cord-002248-92pzqj35	307	12	harbors	harbor	VBZ
cord-002248-92pzqj35	307	13	residual	residual	JJ
cord-002248-92pzqj35	307	14	virulence	virulence	NN
cord-002248-92pzqj35	307	15	in	in	IN
cord-002248-92pzqj35	307	16	a	a	DT
cord-002248-92pzqj35	307	17	young	young	JJ
cord-002248-92pzqj35	307	18	mouse	mouse	NN
cord-002248-92pzqj35	307	19	model	model	NN
cord-002248-92pzqj35	307	20	.	.	.
cord-002248-92pzqj35	308	1	Although	although	IN
cord-002248-92pzqj35	308	2	further	further	JJ
cord-002248-92pzqj35	308	3	studies	study	NNS
cord-002248-92pzqj35	308	4	are	be	VBP
cord-002248-92pzqj35	308	5	required	require	VBN
cord-002248-92pzqj35	308	6	to	to	TO
cord-002248-92pzqj35	308	7	test	test	VB
cord-002248-92pzqj35	308	8	the	the	DT
cord-002248-92pzqj35	308	9	immunogenicity	immunogenicity	NN
cord-002248-92pzqj35	308	10	and	and	CC
cord-002248-92pzqj35	308	11	protective	protective	JJ
cord-002248-92pzqj35	308	12	efficacy	efficacy	NN
cord-002248-92pzqj35	308	13	of	of	IN
cord-002248-92pzqj35	308	14	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	308	15	K	K	NNP
cord-002248-92pzqj35	308	16	and	and	CC
cord-002248-92pzqj35	308	17	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	308	18	/	/	SYM
cord-002248-92pzqj35	308	19	M250	M250	NNP
cord-002248-92pzqj35	308	20	K	K	NNP
cord-002248-92pzqj35	308	21	,	,	,
cord-002248-92pzqj35	308	22	there	there	EX
cord-002248-92pzqj35	308	23	is	be	VBZ
cord-002248-92pzqj35	308	24	a	a	DT
cord-002248-92pzqj35	308	25	potential	potential	NN
cord-002248-92pzqj35	308	26	for	for	IN
cord-002248-92pzqj35	308	27	developing	develop	VBG
cord-002248-92pzqj35	308	28	these	these	DT
cord-002248-92pzqj35	308	29	MP-12-derived	MP-12-derived	NNP
cord-002248-92pzqj35	308	30	NSs	NSs	NNP
cord-002248-92pzqj35	308	31	mutant	mutant	JJ
cord-002248-92pzqj35	308	32	viruses	virus	NNS
cord-002248-92pzqj35	308	33	as	as	IN
cord-002248-92pzqj35	308	34	safer	safe	JJR
cord-002248-92pzqj35	308	35	live	live	JJ
cord-002248-92pzqj35	308	36	attenuated	attenuated	JJ
cord-002248-92pzqj35	308	37	RVFV	RVFV	NNP
cord-002248-92pzqj35	308	38	vaccine	vaccine	NN
cord-002248-92pzqj35	308	39	candidates	candidate	NNS
cord-002248-92pzqj35	308	40	.	.	.
cord-002248-92pzqj35	309	1	We	-PRON-	PRP
cord-002248-92pzqj35	309	2	found	find	VBD
cord-002248-92pzqj35	309	3	that	that	IN
cord-002248-92pzqj35	309	4	the	the	DT
cord-002248-92pzqj35	309	5	serial	serial	JJ
cord-002248-92pzqj35	309	6	passage	passage	NN
cord-002248-92pzqj35	309	7	of	of	IN
cord-002248-92pzqj35	309	8	an	an	DT
cord-002248-92pzqj35	309	9	MP-12-derived	MP-12-derived	NNP
cord-002248-92pzqj35	309	10	mutant	mutant	JJ
cord-002248-92pzqj35	309	11	virus	virus	NN
cord-002248-92pzqj35	309	12	having	have	VBG
cord-002248-92pzqj35	309	13	a	a	DT
cord-002248-92pzqj35	309	14	large	large	JJ
cord-002248-92pzqj35	309	15	deletion	deletion	NN
cord-002248-92pzqj35	309	16	in	in	IN
cord-002248-92pzqj35	309	17	the	the	DT
cord-002248-92pzqj35	309	18	5	5	CD
cord-002248-92pzqj35	309	19	'	'	POS
cord-002248-92pzqj35	309	20	untranslated	untranslated	JJ
cord-002248-92pzqj35	309	21	region	region	NN
cord-002248-92pzqj35	309	22	of	of	IN
cord-002248-92pzqj35	309	23	M	M	NNP
cord-002248-92pzqj35	309	24	RNA	RNA	NNP
cord-002248-92pzqj35	309	25	segment	segment	NN
cord-002248-92pzqj35	309	26	[	[	-LRB-
cord-002248-92pzqj35	309	27	30	30	CD
cord-002248-92pzqj35	309	28	]	]	-RRB-
cord-002248-92pzqj35	309	29	in	in	IN
cord-002248-92pzqj35	309	30	Vero	Vero	NNP
cord-002248-92pzqj35	309	31	E6	E6	NNP
cord-002248-92pzqj35	309	32	cells	cell	NNS
cord-002248-92pzqj35	309	33	resulted	result	VBD
cord-002248-92pzqj35	309	34	in	in	IN
cord-002248-92pzqj35	309	35	accumulation	accumulation	NN
cord-002248-92pzqj35	309	36	of	of	IN
cord-002248-92pzqj35	309	37	variant	variant	NN
cord-002248-92pzqj35	309	38	viruses	virus	NNS
cord-002248-92pzqj35	309	39	that	that	WDT
cord-002248-92pzqj35	309	40	were	be	VBD
cord-002248-92pzqj35	309	41	able	able	JJ
cord-002248-92pzqj35	309	42	to	to	TO
cord-002248-92pzqj35	309	43	replicate	replicate	VB
cord-002248-92pzqj35	309	44	better	well	JJR
cord-002248-92pzqj35	309	45	than	than	IN
cord-002248-92pzqj35	309	46	the	the	DT
cord-002248-92pzqj35	309	47	original	original	JJ
cord-002248-92pzqj35	309	48	mutant	mutant	JJ
cord-002248-92pzqj35	309	49	virus	virus	NN
cord-002248-92pzqj35	309	50	.	.	.
cord-002248-92pzqj35	310	1	Most	Most	JJS
cord-002248-92pzqj35	310	2	of	of	IN
cord-002248-92pzqj35	310	3	viruses	virus	NNS
cord-002248-92pzqj35	310	4	in	in	IN
cord-002248-92pzqj35	310	5	passage	passage	NN
cord-002248-92pzqj35	310	6	18	18	CD
cord-002248-92pzqj35	310	7	had	have	VBD
cord-002248-92pzqj35	310	8	a	a	DT
cord-002248-92pzqj35	310	9	large	large	JJ
cord-002248-92pzqj35	310	10	internal	internal	JJ
cord-002248-92pzqj35	310	11	deletion	deletion	NN
cord-002248-92pzqj35	310	12	in	in	IN
cord-002248-92pzqj35	310	13	the	the	DT
cord-002248-92pzqj35	310	14	NSs	NSs	NNP
cord-002248-92pzqj35	310	15	gene	gene	NN
cord-002248-92pzqj35	310	16	,	,	,
cord-002248-92pzqj35	310	17	which	which	WDT
cord-002248-92pzqj35	310	18	may	may	MD
cord-002248-92pzqj35	310	19	mean	mean	VB
cord-002248-92pzqj35	310	20	their	-PRON-	PRP$
cord-002248-92pzqj35	310	21	NSs	nss	NN
cord-002248-92pzqj35	310	22	proteins	protein	NNS
cord-002248-92pzqj35	310	23	are	be	VBP
cord-002248-92pzqj35	310	24	biologically	biologically	RB
cord-002248-92pzqj35	310	25	inactive	inactive	JJ
cord-002248-92pzqj35	310	26	.	.	.
cord-002248-92pzqj35	311	1	Others	other	NNS
cord-002248-92pzqj35	311	2	have	have	VBP
cord-002248-92pzqj35	311	3	reported	report	VBN
cord-002248-92pzqj35	311	4	that	that	IN
cord-002248-92pzqj35	311	5	RVFV	RVFV	NNP
cord-002248-92pzqj35	311	6	carrying	carry	VBG
cord-002248-92pzqj35	311	7	large	large	JJ
cord-002248-92pzqj35	311	8	deletions	deletion	NNS
cord-002248-92pzqj35	311	9	in	in	IN
cord-002248-92pzqj35	311	10	the	the	DT
cord-002248-92pzqj35	311	11	NSs	NSs	NNP
cord-002248-92pzqj35	311	12	gene	gene	NN
cord-002248-92pzqj35	311	13	start	start	NN
cord-002248-92pzqj35	311	14	accumulating	accumulate	VBG
cord-002248-92pzqj35	311	15	from	from	IN
cord-002248-92pzqj35	311	16	the	the	DT
cord-002248-92pzqj35	311	17	15	15	CD
cord-002248-92pzqj35	311	18	th	th	XX
cord-002248-92pzqj35	311	19	serial	serial	JJ
cord-002248-92pzqj35	311	20	passage	passage	NN
cord-002248-92pzqj35	311	21	in	in	IN
cord-002248-92pzqj35	311	22	BHK	BHK	NNP
cord-002248-92pzqj35	311	23	cells	cell	NNS
cord-002248-92pzqj35	311	24	of	of	IN
cord-002248-92pzqj35	311	25	the	the	DT
cord-002248-92pzqj35	311	26	RVFV	RVFV	NNP
cord-002248-92pzqj35	311	27	P	p	NN
cord-002248-92pzqj35	311	28	strain	strain	NN
cord-002248-92pzqj35	311	29	,	,	,
cord-002248-92pzqj35	311	30	which	which	WDT
cord-002248-92pzqj35	311	31	is	be	VBZ
cord-002248-92pzqj35	311	32	defective	defective	JJ
cord-002248-92pzqj35	311	33	in	in	IN
cord-002248-92pzqj35	311	34	IFN	IFN	NNP
cord-002248-92pzqj35	311	35	-	-	HYPH
cord-002248-92pzqj35	311	36	α	α	NNP
cord-002248-92pzqj35	311	37	/	/	SYM
cord-002248-92pzqj35	311	38	β	β	NN
cord-002248-92pzqj35	311	39	signaling	signal	VBG
cord-002248-92pzqj35	311	40	[	[	-LRB-
cord-002248-92pzqj35	311	41	35	35	CD
cord-002248-92pzqj35	311	42	]	]	-RRB-
cord-002248-92pzqj35	311	43	.	.	.
cord-002248-92pzqj35	312	1	In	in	IN
cord-002248-92pzqj35	312	2	our	-PRON-	PRP$
cord-002248-92pzqj35	312	3	experiment	experiment	NN
cord-002248-92pzqj35	312	4	,	,	,
cord-002248-92pzqj35	312	5	the	the	DT
cord-002248-92pzqj35	312	6	large	large	JJ
cord-002248-92pzqj35	312	7	deletions	deletion	NNS
cord-002248-92pzqj35	312	8	in	in	IN
cord-002248-92pzqj35	312	9	the	the	DT
cord-002248-92pzqj35	312	10	NSs	NSs	NNP
cord-002248-92pzqj35	312	11	gene	gene	NN
cord-002248-92pzqj35	312	12	were	be	VBD
cord-002248-92pzqj35	312	13	detected	detect	VBN
cord-002248-92pzqj35	312	14	after	after	IN
cord-002248-92pzqj35	312	15	the	the	DT
cord-002248-92pzqj35	312	16	5	5	CD
cord-002248-92pzqj35	312	17	th	th	XX
cord-002248-92pzqj35	312	18	serial	serial	JJ
cord-002248-92pzqj35	312	19	passage	passage	NN
cord-002248-92pzqj35	312	20	of	of	IN
cord-002248-92pzqj35	312	21	the	the	DT
cord-002248-92pzqj35	312	22	virus	virus	NN
cord-002248-92pzqj35	312	23	.	.	.
cord-002248-92pzqj35	313	1	Although	although	IN
cord-002248-92pzqj35	313	2	the	the	DT
cord-002248-92pzqj35	313	3	cell	cell	NN
cord-002248-92pzqj35	313	4	lines	line	NNS
cord-002248-92pzqj35	313	5	used	use	VBN
cord-002248-92pzqj35	313	6	in	in	IN
cord-002248-92pzqj35	313	7	the	the	DT
cord-002248-92pzqj35	313	8	studies	study	NNS
cord-002248-92pzqj35	313	9	were	be	VBD
cord-002248-92pzqj35	313	10	different	different	JJ
cord-002248-92pzqj35	313	11	,	,	,
cord-002248-92pzqj35	313	12	the	the	DT
cord-002248-92pzqj35	313	13	deletion	deletion	NN
cord-002248-92pzqj35	313	14	of	of	IN
cord-002248-92pzqj35	313	15	the	the	DT
cord-002248-92pzqj35	313	16	NSs	NSs	NNP
cord-002248-92pzqj35	313	17	gene	gene	NN
cord-002248-92pzqj35	313	18	as	as	RB
cord-002248-92pzqj35	313	19	early	early	RB
cord-002248-92pzqj35	313	20	as	as	IN
cord-002248-92pzqj35	313	21	after	after	IN
cord-002248-92pzqj35	313	22	5	5	CD
cord-002248-92pzqj35	313	23	passages	passage	NNS
cord-002248-92pzqj35	313	24	implied	imply	VBN
cord-002248-92pzqj35	313	25	that	that	IN
cord-002248-92pzqj35	313	26	there	there	EX
cord-002248-92pzqj35	313	27	was	be	VBD
cord-002248-92pzqj35	313	28	a	a	DT
cord-002248-92pzqj35	313	29	selective	selective	JJ
cord-002248-92pzqj35	313	30	pressure	pressure	NN
cord-002248-92pzqj35	313	31	to	to	TO
cord-002248-92pzqj35	313	32	remove	remove	VB
cord-002248-92pzqj35	313	33	the	the	DT
cord-002248-92pzqj35	313	34	NSs	NSs	NNP
cord-002248-92pzqj35	313	35	gene	gene	NN
cord-002248-92pzqj35	313	36	from	from	IN
cord-002248-92pzqj35	313	37	the	the	DT
cord-002248-92pzqj35	313	38	virus	virus	NN
cord-002248-92pzqj35	313	39	genome	genome	NN
cord-002248-92pzqj35	313	40	during	during	IN
cord-002248-92pzqj35	313	41	the	the	DT
cord-002248-92pzqj35	313	42	passaging	passaging	NN
cord-002248-92pzqj35	313	43	of	of	IN
cord-002248-92pzqj35	313	44	the	the	DT
cord-002248-92pzqj35	313	45	mutant	mutant	JJ
cord-002248-92pzqj35	313	46	virus	virus	NN
cord-002248-92pzqj35	313	47	.	.	.
cord-002248-92pzqj35	314	1	The	the	DT
cord-002248-92pzqj35	314	2	full	full	JJ
cord-002248-92pzqj35	314	3	-	-	HYPH
cord-002248-92pzqj35	314	4	length	length	NN
cord-002248-92pzqj35	314	5	NSs	NSs	NNP
cord-002248-92pzqj35	314	6	gene	gene	NN
cord-002248-92pzqj35	314	7	of	of	IN
cord-002248-92pzqj35	314	8	the	the	DT
cord-002248-92pzqj35	314	9	uncloned	uncloned	JJ
cord-002248-92pzqj35	314	10	passage	passage	NN
cord-002248-92pzqj35	314	11	18	18	CD
cord-002248-92pzqj35	314	12	viruses	virus	NNS
cord-002248-92pzqj35	314	13	had	have	VBD
cord-002248-92pzqj35	314	14	M250	M250	NNP
cord-002248-92pzqj35	314	15	K	K	NNP
cord-002248-92pzqj35	314	16	,	,	,
cord-002248-92pzqj35	314	17	M250	M250	NNP
cord-002248-92pzqj35	314	18	T	T	NNP
cord-002248-92pzqj35	314	19	,	,	,
cord-002248-92pzqj35	314	20	K202N	K202N	NNP
cord-002248-92pzqj35	314	21	and	and	CC
cord-002248-92pzqj35	314	22	D100	D100	NNP
cord-002248-92pzqj35	314	23	G	g	NN
cord-002248-92pzqj35	314	24	mutations	mutation	NNS
cord-002248-92pzqj35	314	25	(	(	-LRB-
cord-002248-92pzqj35	314	26	Table	table	NN
cord-002248-92pzqj35	314	27	1	1	CD
cord-002248-92pzqj35	314	28	)	)	-RRB-
cord-002248-92pzqj35	314	29	.	.	.
cord-002248-92pzqj35	315	1	In	in	IN
cord-002248-92pzqj35	315	2	the	the	DT
cord-002248-92pzqj35	315	3	cells	cell	NNS
cord-002248-92pzqj35	315	4	infected	infect	VBN
cord-002248-92pzqj35	315	5	with	with	IN
cord-002248-92pzqj35	315	6	MP-12	MP-12	NNP
cord-002248-92pzqj35	315	7	carrying	carry	VBG
cord-002248-92pzqj35	315	8	NSs	ns	NNS
cord-002248-92pzqj35	315	9	with	with	IN
cord-002248-92pzqj35	315	10	a	a	DT
cord-002248-92pzqj35	315	11	D100	D100	NNP
cord-002248-92pzqj35	315	12	G	G	NNP
cord-002248-92pzqj35	315	13	mutation	mutation	NN
cord-002248-92pzqj35	315	14	,	,	,
cord-002248-92pzqj35	315	15	the	the	DT
cord-002248-92pzqj35	315	16	accumulation	accumulation	NN
cord-002248-92pzqj35	315	17	of	of	IN
cord-002248-92pzqj35	315	18	NSs	NSs	NNP
cord-002248-92pzqj35	315	19	was	be	VBD
cord-002248-92pzqj35	315	20	poor	poor	JJ
cord-002248-92pzqj35	315	21	(	(	-LRB-
cord-002248-92pzqj35	315	22	Fig	Fig	NNP
cord-002248-92pzqj35	315	23	1	1	CD
cord-002248-92pzqj35	315	24	)	)	-RRB-
cord-002248-92pzqj35	315	25	,	,	,
cord-002248-92pzqj35	315	26	indicating	indicate	VBG
cord-002248-92pzqj35	315	27	that	that	IN
cord-002248-92pzqj35	315	28	the	the	DT
cord-002248-92pzqj35	315	29	D100	D100	NNP
cord-002248-92pzqj35	315	30	G	G	NNP
cord-002248-92pzqj35	315	31	mutation	mutation	NN
cord-002248-92pzqj35	315	32	affects	affect	VBZ
cord-002248-92pzqj35	315	33	the	the	DT
cord-002248-92pzqj35	315	34	efficient	efficient	JJ
cord-002248-92pzqj35	315	35	accumulation	accumulation	NN
cord-002248-92pzqj35	315	36	of	of	IN
cord-002248-92pzqj35	315	37	NSs	NSs	NNP
cord-002248-92pzqj35	315	38	.	.	.
cord-002248-92pzqj35	316	1	As	as	IN
cord-002248-92pzqj35	316	2	two	two	CD
cord-002248-92pzqj35	316	3	out	out	IN
cord-002248-92pzqj35	316	4	of	of	IN
cord-002248-92pzqj35	316	5	the	the	DT
cord-002248-92pzqj35	316	6	five	five	CD
cord-002248-92pzqj35	316	7	plaque	plaque	NN
cord-002248-92pzqj35	316	8	-	-	HYPH
cord-002248-92pzqj35	316	9	cloned	clone	VBN
cord-002248-92pzqj35	316	10	viruses	virus	NNS
cord-002248-92pzqj35	316	11	(	(	-LRB-
cord-002248-92pzqj35	316	12	clones	clone	NNS
cord-002248-92pzqj35	316	13	3	3	CD
cord-002248-92pzqj35	316	14	and	and	CC
cord-002248-92pzqj35	316	15	4	4	CD
cord-002248-92pzqj35	316	16	,	,	,
cord-002248-92pzqj35	316	17	Table	table	NN
cord-002248-92pzqj35	316	18	1	1	CD
cord-002248-92pzqj35	316	19	)	)	-RRB-
cord-002248-92pzqj35	316	20	also	also	RB
cord-002248-92pzqj35	316	21	had	have	VBD
cord-002248-92pzqj35	316	22	the	the	DT
cord-002248-92pzqj35	316	23	D100	D100	NNP
cord-002248-92pzqj35	316	24	G	G	NNP
cord-002248-92pzqj35	316	25	mutation	mutation	NN
cord-002248-92pzqj35	316	26	in	in	IN
cord-002248-92pzqj35	316	27	NSs	NSs	NNP
cord-002248-92pzqj35	316	28	,	,	,
cord-002248-92pzqj35	316	29	this	this	DT
cord-002248-92pzqj35	316	30	possibly	possibly	RB
cord-002248-92pzqj35	316	31	affected	affect	VBD
cord-002248-92pzqj35	316	32	its	-PRON-	PRP$
cord-002248-92pzqj35	316	33	accumulation	accumulation	NN
cord-002248-92pzqj35	316	34	in	in	IN
cord-002248-92pzqj35	316	35	infected	infected	JJ
cord-002248-92pzqj35	316	36	cells	cell	NNS
cord-002248-92pzqj35	316	37	.	.	.
cord-002248-92pzqj35	317	1	The	the	DT
cord-002248-92pzqj35	317	2	remaining	remain	VBG
cord-002248-92pzqj35	317	3	three	three	CD
cord-002248-92pzqj35	317	4	clones	clone	NNS
cord-002248-92pzqj35	317	5	carried	carry	VBD
cord-002248-92pzqj35	317	6	NSs	NSs	NNP
cord-002248-92pzqj35	317	7	with	with	IN
cord-002248-92pzqj35	317	8	a	a	DT
cord-002248-92pzqj35	317	9	M250	M250	NNP
cord-002248-92pzqj35	317	10	K	K	NNP
cord-002248-92pzqj35	317	11	or	or	CC
cord-002248-92pzqj35	317	12	R16H	R16H	NNP
cord-002248-92pzqj35	317	13	/	/	,
cord-002248-92pzqj35	317	14	M250	M250	NNP
cord-002248-92pzqj35	317	15	K	K	NNP
cord-002248-92pzqj35	317	16	mutation	mutation	NN
cord-002248-92pzqj35	317	17	.	.	.
cord-002248-92pzqj35	318	1	Our	-PRON-	PRP$
cord-002248-92pzqj35	318	2	results	result	NNS
cord-002248-92pzqj35	318	3	showed	show	VBD
cord-002248-92pzqj35	318	4	that	that	IN
cord-002248-92pzqj35	318	5	these	these	DT
cord-002248-92pzqj35	318	6	mutations	mutation	NNS
cord-002248-92pzqj35	318	7	in	in	IN
cord-002248-92pzqj35	318	8	NSs	NSs	NNP
cord-002248-92pzqj35	318	9	partially	partially	RB
cord-002248-92pzqj35	318	10	or	or	CC
cord-002248-92pzqj35	318	11	completely	completely	RB
cord-002248-92pzqj35	318	12	abolished	abolish	VBD
cord-002248-92pzqj35	318	13	its	-PRON-	PRP$
cord-002248-92pzqj35	318	14	host	host	NN
cord-002248-92pzqj35	318	15	transcription	transcription	NN
cord-002248-92pzqj35	318	16	inhibition	inhibition	NN
cord-002248-92pzqj35	318	17	function	function	NN
cord-002248-92pzqj35	318	18	without	without	IN
cord-002248-92pzqj35	318	19	affecting	affect	VBG
cord-002248-92pzqj35	318	20	its	-PRON-	PRP$
cord-002248-92pzqj35	318	21	ability	ability	NN
cord-002248-92pzqj35	318	22	to	to	TO
cord-002248-92pzqj35	318	23	interact	interact	VB
cord-002248-92pzqj35	318	24	with	with	IN
cord-002248-92pzqj35	318	25	SAP30	SAP30	NNP
cord-002248-92pzqj35	318	26	to	to	TO
cord-002248-92pzqj35	318	27	inhibit	inhibit	VB
cord-002248-92pzqj35	318	28	IFN	IFN	NNP
cord-002248-92pzqj35	318	29	-	-	HYPH
cord-002248-92pzqj35	318	30	β	β	NNP
cord-002248-92pzqj35	318	31	mRNA	mrna	NN
cord-002248-92pzqj35	318	32	synthesis	synthesis	NN
cord-002248-92pzqj35	318	33	.	.	.
cord-002248-92pzqj35	319	1	These	these	DT
cord-002248-92pzqj35	319	2	data	datum	NNS
cord-002248-92pzqj35	319	3	implied	imply	VBD
cord-002248-92pzqj35	319	4	that	that	IN
cord-002248-92pzqj35	319	5	the	the	DT
cord-002248-92pzqj35	319	6	host	host	NN
cord-002248-92pzqj35	319	7	transcription	transcription	NN
cord-002248-92pzqj35	319	8	function	function	NN
cord-002248-92pzqj35	319	9	of	of	IN
cord-002248-92pzqj35	319	10	NSs	NSs	NNP
cord-002248-92pzqj35	319	11	was	be	VBD
cord-002248-92pzqj35	319	12	unfavorable	unfavorable	JJ
cord-002248-92pzqj35	319	13	for	for	IN
cord-002248-92pzqj35	319	14	the	the	DT
cord-002248-92pzqj35	319	15	mutant	mutant	JJ
cord-002248-92pzqj35	319	16	virus	virus	NN
cord-002248-92pzqj35	319	17	,	,	,
cord-002248-92pzqj35	319	18	carrying	carry	VBG
cord-002248-92pzqj35	319	19	a	a	DT
cord-002248-92pzqj35	319	20	deletion	deletion	NN
cord-002248-92pzqj35	319	21	in	in	IN
cord-002248-92pzqj35	319	22	the	the	DT
cord-002248-92pzqj35	319	23	5	5	CD
cord-002248-92pzqj35	319	24	'	'	POS
cord-002248-92pzqj35	319	25	UTR	UTR	NNP
cord-002248-92pzqj35	319	26	,	,	,
cord-002248-92pzqj35	319	27	to	to	TO
cord-002248-92pzqj35	319	28	replicate	replicate	VB
cord-002248-92pzqj35	319	29	well	well	RB
cord-002248-92pzqj35	319	30	in	in	IN
cord-002248-92pzqj35	319	31	VeroE6	veroe6	NN
cord-002248-92pzqj35	319	32	cells	cell	NNS
cord-002248-92pzqj35	319	33	.	.	.
cord-002248-92pzqj35	320	1	MP-12-M250	MP-12-M250	NNP
cord-002248-92pzqj35	320	2	K	K	NNP
cord-002248-92pzqj35	320	3	and	and	CC
cord-002248-92pzqj35	320	4	MP-12-R16H	MP-12-R16H	NNP
cord-002248-92pzqj35	320	5	/	/	SYM
cord-002248-92pzqj35	320	6	M250	M250	NNP
cord-002248-92pzqj35	320	7	K	K	NNP
cord-002248-92pzqj35	320	8	replication	replication	NN
cord-002248-92pzqj35	320	9	induced	induce	VBN
cord-002248-92pzqj35	320	10	low	low	JJ
cord-002248-92pzqj35	320	11	cytotoxicity	cytotoxicity	NN
cord-002248-92pzqj35	320	12	due	due	IN
cord-002248-92pzqj35	320	13	to	to	IN
cord-002248-92pzqj35	320	14	its	-PRON-	PRP$
cord-002248-92pzqj35	320	15	lower	low	JJR
cord-002248-92pzqj35	320	16	inhibitory	inhibitory	JJ
cord-002248-92pzqj35	320	17	activity	activity	NN
cord-002248-92pzqj35	320	18	on	on	IN
cord-002248-92pzqj35	320	19	host	host	NN
cord-002248-92pzqj35	320	20	transcription	transcription	NN
cord-002248-92pzqj35	320	21	(	(	-LRB-
cord-002248-92pzqj35	320	22	Figs	Figs	NNP
cord-002248-92pzqj35	320	23	2	2	CD
cord-002248-92pzqj35	320	24	and	and	CC
cord-002248-92pzqj35	320	25	3	3	CD
cord-002248-92pzqj35	320	26	)	)	-RRB-
cord-002248-92pzqj35	320	27	.	.	.
cord-002248-92pzqj35	321	1	We	-PRON-	PRP
cord-002248-92pzqj35	321	2	suspect	suspect	VBP
cord-002248-92pzqj35	321	3	that	that	IN
cord-002248-92pzqj35	321	4	the	the	DT
cord-002248-92pzqj35	321	5	lack	lack	NN
cord-002248-92pzqj35	321	6	of	of	IN
cord-002248-92pzqj35	321	7	NSs	nss	NN
cord-002248-92pzqj35	321	8	-	-	HYPH
cord-002248-92pzqj35	321	9	induced	induce	VBN
cord-002248-92pzqj35	321	10	host	host	NN
cord-002248-92pzqj35	321	11	transcription	transcription	NN
cord-002248-92pzqj35	321	12	suppression	suppression	NN
cord-002248-92pzqj35	321	13	created	create	VBD
cord-002248-92pzqj35	321	14	a	a	DT
cord-002248-92pzqj35	321	15	favorable	favorable	JJ
cord-002248-92pzqj35	321	16	cellular	cellular	JJ
cord-002248-92pzqj35	321	17	environment	environment	NN
cord-002248-92pzqj35	321	18	for	for	IN
cord-002248-92pzqj35	321	19	the	the	DT
cord-002248-92pzqj35	321	20	mutant	mutant	JJ
cord-002248-92pzqj35	321	21	virus	virus	NN
cord-002248-92pzqj35	321	22	,	,	,
cord-002248-92pzqj35	321	23	thereby	thereby	RB
cord-002248-92pzqj35	321	24	allowing	allow	VBG
cord-002248-92pzqj35	321	25	the	the	DT
cord-002248-92pzqj35	321	26	emergence	emergence	NN
cord-002248-92pzqj35	321	27	and	and	CC
cord-002248-92pzqj35	321	28	accumulation	accumulation	NN
cord-002248-92pzqj35	321	29	of	of	IN
cord-002248-92pzqj35	321	30	mutant	mutant	JJ
cord-002248-92pzqj35	321	31	viruses	virus	NNS
cord-002248-92pzqj35	321	32	that	that	WDT
cord-002248-92pzqj35	321	33	lacked	lack	VBD
cord-002248-92pzqj35	321	34	this	this	DT
cord-002248-92pzqj35	321	35	function	function	NN
cord-002248-92pzqj35	321	36	.	.	.
cord-002248-92pzqj35	322	1	Further	further	JJ
cord-002248-92pzqj35	322	2	studies	study	NNS
cord-002248-92pzqj35	322	3	are	be	VBP
cord-002248-92pzqj35	322	4	required	require	VBN
cord-002248-92pzqj35	322	5	to	to	TO
cord-002248-92pzqj35	322	6	delineate	delineate	VB
cord-002248-92pzqj35	322	7	the	the	DT
cord-002248-92pzqj35	322	8	importance	importance	NN
cord-002248-92pzqj35	322	9	of	of	IN
cord-002248-92pzqj35	322	10	NSs	NSs	NNP
cord-002248-92pzqj35	322	11	-	-	HYPH
cord-002248-92pzqj35	322	12	mediated	mediate	VBN
cord-002248-92pzqj35	322	13	host	host	NN
cord-002248-92pzqj35	322	14	transcription	transcription	NN
cord-002248-92pzqj35	322	15	inhibition	inhibition	NN
cord-002248-92pzqj35	322	16	in	in	IN
cord-002248-92pzqj35	322	17	the	the	DT
cord-002248-92pzqj35	322	18	virus	virus	NN
cord-002248-92pzqj35	322	19	life	life	NN
cord-002248-92pzqj35	322	20	cycle	cycle	NN
cord-002248-92pzqj35	322	21	.	.	.
cord-002248-92pzqj35	323	1	with	with	IN
cord-002248-92pzqj35	323	2	MP-12-NSs	MP-12-NSs	NNP
cord-002248-92pzqj35	323	3	-	-	HYPH
cord-002248-92pzqj35	323	4	Flag	Flag	NNP
cord-002248-92pzqj35	323	5	or	or	CC
cord-002248-92pzqj35	323	6	its	-PRON-	PRP$
cord-002248-92pzqj35	323	7	mutants	mutant	NNS
cord-002248-92pzqj35	323	8	,	,	,
cord-002248-92pzqj35	323	9	at	at	IN
cord-002248-92pzqj35	323	10	an	an	DT
cord-002248-92pzqj35	323	11	m.o.i	m.o.i	NN
cord-002248-92pzqj35	323	12	.	.	NN
cord-002248-92pzqj35	323	13	of	of	IN
cord-002248-92pzqj35	323	14	2	2	CD
cord-002248-92pzqj35	323	15	and	and	CC
cord-002248-92pzqj35	323	16	at	at	IN
cord-002248-92pzqj35	323	17	6	6	CD
cord-002248-92pzqj35	323	18	h	h	NN
cord-002248-92pzqj35	323	19	p.i	p.i	NNP
cord-002248-92pzqj35	323	20	.	.	NNP
cord-002248-92pzqj35	323	21	,	,	,
cord-002248-92pzqj35	323	22	the	the	DT
cord-002248-92pzqj35	323	23	cells	cell	NNS
cord-002248-92pzqj35	323	24	were	be	VBD
cord-002248-92pzqj35	323	25	lysed	lyse	VBN
cord-002248-92pzqj35	323	26	using	use	VBG
cord-002248-92pzqj35	323	27	the	the	DT
cord-002248-92pzqj35	323	28	lysis	lysis	NN
cord-002248-92pzqj35	323	29	buffer	buffer	NN
cord-002248-92pzqj35	323	30	(	(	-LRB-
cord-002248-92pzqj35	323	31	10	10	CD
cord-002248-92pzqj35	323	32	mM	mM	NNP
cord-002248-92pzqj35	323	33	Tris	Tris	NNP
cord-002248-92pzqj35	323	34	-	-	HYPH
cord-002248-92pzqj35	323	35	HCl	HCl	NNP
cord-002248-92pzqj35	323	36	,	,	,
cord-002248-92pzqj35	323	37	pH	pH	NNP
cord-002248-92pzqj35	323	38	7.5	7.5	CD
cord-002248-92pzqj35	323	39	,	,	,
cord-002248-92pzqj35	323	40	10	10	CD
cord-002248-92pzqj35	323	41	mM	mm	CD
cord-002248-92pzqj35	323	42	KCl	KCl	NNS
cord-002248-92pzqj35	323	43	,	,	,
cord-002248-92pzqj35	323	44	1.5	1.5	CD
cord-002248-92pzqj35	323	45	mM	mm	CD
cord-002248-92pzqj35	323	46	MgCl	MgCl	NNP
cord-002248-92pzqj35	323	47	2	2	CD
cord-002248-92pzqj35	323	48	,	,	,
cord-002248-92pzqj35	323	49	0.5	0.5	CD
cord-002248-92pzqj35	323	50	%	%	NN
cord-002248-92pzqj35	323	51	Triton	Triton	NNP
cord-002248-92pzqj35	323	52	X-100	x-100	NN
cord-002248-92pzqj35	323	53	,	,	,
cord-002248-92pzqj35	324	1	protease	protease	NN
cord-002248-92pzqj35	324	2	inhibitor	inhibitor	NN
cord-002248-92pzqj35	324	3	cocktail	cocktail	NN
cord-002248-92pzqj35	324	4	)	)	-RRB-
cord-002248-92pzqj35	324	5	followed	follow	VBN
cord-002248-92pzqj35	324	6	by	by	IN
cord-002248-92pzqj35	324	7	incubation	incubation	NN
cord-002248-92pzqj35	324	8	on	on	IN
cord-002248-92pzqj35	324	9	ice	ice	NN
cord-002248-92pzqj35	324	10	for	for	IN
cord-002248-92pzqj35	324	11	10	10	CD
cord-002248-92pzqj35	324	12	min	min	NN
cord-002248-92pzqj35	324	13	.	.	.
cord-002248-92pzqj35	325	1	After	after	IN
cord-002248-92pzqj35	325	2	centrifugation	centrifugation	NN
cord-002248-92pzqj35	325	3	at	at	IN
cord-002248-92pzqj35	325	4	2,000	2,000	CD
cord-002248-92pzqj35	325	5	x	x	SYM
cord-002248-92pzqj35	325	6	g	g	NN
cord-002248-92pzqj35	325	7	for	for	IN
cord-002248-92pzqj35	325	8	2	2	CD
cord-002248-92pzqj35	325	9	min	min	NN
cord-002248-92pzqj35	325	10	,	,	,
cord-002248-92pzqj35	325	11	the	the	DT
cord-002248-92pzqj35	325	12	resulting	result	VBG
cord-002248-92pzqj35	325	13	supernatant	supernatant	NN
cord-002248-92pzqj35	325	14	was	be	VBD
cord-002248-92pzqj35	325	15	collected	collect	VBN
cord-002248-92pzqj35	325	16	as	as	IN
cord-002248-92pzqj35	325	17	the	the	DT
cord-002248-92pzqj35	325	18	cytoplasmic	cytoplasmic	JJ
cord-002248-92pzqj35	325	19	fraction	fraction	NN
cord-002248-92pzqj35	325	20	(	(	-LRB-
cord-002248-92pzqj35	325	21	C	C	NNP
cord-002248-92pzqj35	325	22	)	)	-RRB-
cord-002248-92pzqj35	325	23	.	.	.
cord-002248-92pzqj35	326	1	The	the	DT
cord-002248-92pzqj35	326	2	pellet	pellet	NN
cord-002248-92pzqj35	326	3	from	from	IN
cord-002248-92pzqj35	326	4	this	this	DT
cord-002248-92pzqj35	326	5	centrifugation	centrifugation	NN
cord-002248-92pzqj35	326	6	was	be	VBD
cord-002248-92pzqj35	326	7	washed	wash	VBN
cord-002248-92pzqj35	326	8	once	once	RB
cord-002248-92pzqj35	326	9	with	with	IN
cord-002248-92pzqj35	326	10	the	the	DT
cord-002248-92pzqj35	326	11	lysis	lysis	NN
cord-002248-92pzqj35	326	12	buffer	buffer	NN
cord-002248-92pzqj35	326	13	(	(	-LRB-
cord-002248-92pzqj35	326	14	without	without	IN
cord-002248-92pzqj35	326	15	Triton	Triton	NNP
cord-002248-92pzqj35	326	16	X-100	x-100	NN
cord-002248-92pzqj35	326	17	)	)	-RRB-
cord-002248-92pzqj35	326	18	,	,	,
cord-002248-92pzqj35	326	19	suspended	suspend	VBN
cord-002248-92pzqj35	326	20	in	in	IN
cord-002248-92pzqj35	326	21	1X	1x	JJ
cord-002248-92pzqj35	326	22	SDS	SDS	NNP
cord-002248-92pzqj35	326	23	sample	sample	NN
cord-002248-92pzqj35	326	24	buffer	buffer	NN
cord-002248-92pzqj35	326	25	and	and	CC
cord-002248-92pzqj35	326	26	denoted	denote	VBN
cord-002248-92pzqj35	326	27	as	as	IN
cord-002248-92pzqj35	326	28	the	the	DT
cord-002248-92pzqj35	326	29	nuclear	nuclear	JJ
cord-002248-92pzqj35	326	30	fraction	fraction	NN
cord-002248-92pzqj35	326	31	(	(	-LRB-
cord-002248-92pzqj35	326	32	N	N	NNP
cord-002248-92pzqj35	326	33	)	)	-RRB-
cord-002248-92pzqj35	326	34	.	.	.
cord-002248-92pzqj35	327	1	The	the	DT
cord-002248-92pzqj35	327	2	subcellular	subcellular	JJ
cord-002248-92pzqj35	327	3	fractions	fraction	NNS
cord-002248-92pzqj35	327	4	were	be	VBD
cord-002248-92pzqj35	327	5	analyzed	analyze	VBN
cord-002248-92pzqj35	327	6	by	by	IN
cord-002248-92pzqj35	327	7	Western	western	JJ
cord-002248-92pzqj35	327	8	blotting	blotting	NN
cord-002248-92pzqj35	327	9	using	use	VBG
cord-002248-92pzqj35	327	10	anti	anti	JJ
cord-002248-92pzqj35	327	11	-	-	JJ
cord-002248-92pzqj35	327	12	Flag	flag	JJ
cord-002248-92pzqj35	327	13	,	,	,
cord-002248-92pzqj35	327	14	anti	anti	JJ
cord-002248-92pzqj35	327	15	-	-	JJ
cord-002248-92pzqj35	327	16	HSP90	hsp90	JJ
cord-002248-92pzqj35	327	17	and	and	CC
cord-002248-92pzqj35	327	18	anti	anti	JJ
cord-002248-92pzqj35	327	19	-	-	JJ
cord-002248-92pzqj35	327	20	Lamin	Lamin	NNP
cord-002248-92pzqj35	327	21	A	A	NNP
cord-002248-92pzqj35	327	22	antibodies	antibody	NNS
cord-002248-92pzqj35	327	23	.	.	.
cord-002248-92pzqj35	328	1	(	(	-LRB-
cord-002248-92pzqj35	328	2	TIF	tif	NN
cord-002248-92pzqj35	328	3	)	)	-RRB-
cord-002248-92pzqj35	329	1	Breaking	break	VBG
cord-002248-92pzqj35	329	2	the	the	DT
cord-002248-92pzqj35	329	3	chain	chain	NN
cord-002248-92pzqj35	329	4	:	:	:
cord-002248-92pzqj35	330	1	Rift	Rift	NNP
cord-002248-92pzqj35	330	2	Valley	Valley	NNP
cord-002248-92pzqj35	330	3	fever	fever	NN
cord-002248-92pzqj35	330	4	virus	virus	NN
cord-002248-92pzqj35	330	5	control	control	NN
cord-002248-92pzqj35	330	6	via	via	IN
cord-002248-92pzqj35	330	7	livestock	livestock	NN
cord-002248-92pzqj35	330	8	vaccination	vaccination	NN
cord-002248-92pzqj35	331	1	The	the	DT
cord-002248-92pzqj35	331	2	Pathogenesis	Pathogenesis	NNP
cord-002248-92pzqj35	331	3	of	of	IN
cord-002248-92pzqj35	331	4	Rift	Rift	NNP
cord-002248-92pzqj35	331	5	Valley	Valley	NNP
cord-002248-92pzqj35	331	6	Fever	Fever	NNP
cord-002248-92pzqj35	331	7	NSm	NSm	NNS
cord-002248-92pzqj35	331	8	and	and	CC
cord-002248-92pzqj35	331	9	78-kilodalton	78-kilodalton	CD
cord-002248-92pzqj35	331	10	proteins	protein	NNS
cord-002248-92pzqj35	331	11	of	of	IN
cord-002248-92pzqj35	331	12	Rift	Rift	NNP
cord-002248-92pzqj35	331	13	Valley	Valley	NNP
cord-002248-92pzqj35	331	14	fever	fever	NN
cord-002248-92pzqj35	331	15	virus	virus	NN
cord-002248-92pzqj35	331	16	are	be	VBP
cord-002248-92pzqj35	331	17	nonessential	nonessential	JJ
cord-002248-92pzqj35	331	18	for	for	IN
cord-002248-92pzqj35	331	19	viral	viral	JJ
cord-002248-92pzqj35	331	20	replication	replication	NN
cord-002248-92pzqj35	331	21	in	in	IN
cord-002248-92pzqj35	331	22	cell	cell	NN
cord-002248-92pzqj35	331	23	culture	culture	NN
cord-002248-92pzqj35	331	24	Deletion	deletion	NN
cord-002248-92pzqj35	331	25	of	of	IN
cord-002248-92pzqj35	331	26	the	the	DT
cord-002248-92pzqj35	331	27	NSm	NSm	NNP
cord-002248-92pzqj35	331	28	virulence	virulence	NN
cord-002248-92pzqj35	331	29	gene	gene	NN
cord-002248-92pzqj35	331	30	of	of	IN
cord-002248-92pzqj35	331	31	Rift	Rift	NNP
cord-002248-92pzqj35	331	32	Valley	Valley	NNP
cord-002248-92pzqj35	331	33	fever	fever	NN
cord-002248-92pzqj35	331	34	virus	virus	NN
cord-002248-92pzqj35	331	35	inhibits	inhibit	VBZ
cord-002248-92pzqj35	331	36	virus	virus	NN
cord-002248-92pzqj35	331	37	replication	replication	NN
cord-002248-92pzqj35	331	38	in	in	IN
cord-002248-92pzqj35	331	39	and	and	CC
cord-002248-92pzqj35	331	40	dissemination	dissemination	NN
cord-002248-92pzqj35	331	41	from	from	IN
cord-002248-92pzqj35	331	42	the	the	DT
cord-002248-92pzqj35	331	43	midgut	midgut	NN
cord-002248-92pzqj35	331	44	of	of	IN
cord-002248-92pzqj35	331	45	Aedes	Aedes	NNP
cord-002248-92pzqj35	331	46	aegypti	aegypti	NN
cord-002248-92pzqj35	331	47	mosquitoes	mosquito	NNS
cord-002248-92pzqj35	331	48	The	the	DT
cord-002248-92pzqj35	331	49	Rift	Rift	NNP
cord-002248-92pzqj35	331	50	Valley	Valley	NNP
cord-002248-92pzqj35	331	51	fever	fever	NN
cord-002248-92pzqj35	331	52	accessory	accessory	NN
cord-002248-92pzqj35	331	53	proteins	protein	NNS
cord-002248-92pzqj35	331	54	NSm	NSm	NNS
cord-002248-92pzqj35	331	55	and	and	CC
cord-002248-92pzqj35	331	56	P78	P78	NNP
cord-002248-92pzqj35	331	57	/	/	SYM
cord-002248-92pzqj35	331	58	NSm	NSm	NNP
cord-002248-92pzqj35	331	59	-	-	HYPH
cord-002248-92pzqj35	331	60	GN	GN	NNP
cord-002248-92pzqj35	331	61	are	be	VBP
cord-002248-92pzqj35	331	62	distinct	distinct	JJ
cord-002248-92pzqj35	331	63	determinants	determinant	NNS
cord-002248-92pzqj35	331	64	of	of	IN
cord-002248-92pzqj35	331	65	virus	virus	NN
cord-002248-92pzqj35	331	66	propagation	propagation	NN
cord-002248-92pzqj35	331	67	in	in	IN
cord-002248-92pzqj35	331	68	vertebrate	vertebrate	JJ
cord-002248-92pzqj35	331	69	and	and	CC
cord-002248-92pzqj35	331	70	invertebrate	invertebrate	JJ
cord-002248-92pzqj35	331	71	hosts	host	NNS
cord-002248-92pzqj35	331	72	NSm	NSm	NNP
cord-002248-92pzqj35	331	73	protein	protein	NN
cord-002248-92pzqj35	331	74	of	of	IN
cord-002248-92pzqj35	331	75	Rift	Rift	NNP
cord-002248-92pzqj35	331	76	Valley	Valley	NNP
cord-002248-92pzqj35	331	77	fever	fever	NN
cord-002248-92pzqj35	331	78	virus	virus	NN
cord-002248-92pzqj35	331	79	suppresses	suppress	VBZ
cord-002248-92pzqj35	332	1	virusinduced	virusinduce	VBN
cord-002248-92pzqj35	332	2	apoptosis	apoptosis	NNP
cord-002248-92pzqj35	333	1	The	the	DT
cord-002248-92pzqj35	333	2	C	c	NN
cord-002248-92pzqj35	333	3	-	-	HYPH
cord-002248-92pzqj35	333	4	terminal	terminal	NN
cord-002248-92pzqj35	333	5	region	region	NN
cord-002248-92pzqj35	333	6	of	of	IN
cord-002248-92pzqj35	333	7	Rift	Rift	NNP
cord-002248-92pzqj35	333	8	Valley	Valley	NNP
cord-002248-92pzqj35	333	9	fever	fever	NN
cord-002248-92pzqj35	333	10	virus	virus	NN
cord-002248-92pzqj35	333	11	NSm	NSm	NNP
cord-002248-92pzqj35	333	12	protein	protein	NN
cord-002248-92pzqj35	333	13	targets	target	VBZ
cord-002248-92pzqj35	333	14	the	the	DT
cord-002248-92pzqj35	333	15	protein	protein	NN
cord-002248-92pzqj35	333	16	to	to	IN
cord-002248-92pzqj35	333	17	the	the	DT
cord-002248-92pzqj35	333	18	mitochondrial	mitochondrial	JJ
cord-002248-92pzqj35	333	19	outer	outer	JJ
cord-002248-92pzqj35	333	20	membrane	membrane	NN
cord-002248-92pzqj35	333	21	and	and	CC
cord-002248-92pzqj35	333	22	exerts	exert	VBZ
cord-002248-92pzqj35	333	23	antiapoptotic	antiapoptotic	JJ
cord-002248-92pzqj35	333	24	function	function	NN
cord-002248-92pzqj35	334	1	Recent	recent	JJ
cord-002248-92pzqj35	334	2	advances	advance	NNS
cord-002248-92pzqj35	334	3	in	in	IN
cord-002248-92pzqj35	334	4	the	the	DT
cord-002248-92pzqj35	334	5	molecular	molecular	JJ
cord-002248-92pzqj35	334	6	and	and	CC
cord-002248-92pzqj35	334	7	cellular	cellular	JJ
cord-002248-92pzqj35	334	8	biology	biology	NN
cord-002248-92pzqj35	334	9	of	of	IN
cord-002248-92pzqj35	334	10	bunyaviruses	bunyavirus	NNS
cord-002248-92pzqj35	335	1	The	the	DT
cord-002248-92pzqj35	335	2	Rift	Rift	NNP
cord-002248-92pzqj35	335	3	Valley	Valley	NNP
cord-002248-92pzqj35	335	4	fever	fever	NN
cord-002248-92pzqj35	335	5	virus	virus	NN
cord-002248-92pzqj35	335	6	nonstructural	nonstructural	JJ
cord-002248-92pzqj35	335	7	protein	protein	NN
cord-002248-92pzqj35	335	8	NSs	NSs	NNP
cord-002248-92pzqj35	335	9	is	be	VBZ
cord-002248-92pzqj35	335	10	phosphorylated	phosphorylate	VBN
cord-002248-92pzqj35	335	11	at	at	IN
cord-002248-92pzqj35	335	12	serine	serine	JJ
cord-002248-92pzqj35	335	13	residues	residue	NNS
cord-002248-92pzqj35	335	14	located	locate	VBN
cord-002248-92pzqj35	335	15	in	in	IN
cord-002248-92pzqj35	335	16	casein	casein	NNP
cord-002248-92pzqj35	335	17	kinase	kinase	NNP
cord-002248-92pzqj35	335	18	II	II	NNP
cord-002248-92pzqj35	335	19	consensus	consensus	NN
cord-002248-92pzqj35	335	20	motifs	motif	NNS
cord-002248-92pzqj35	335	21	in	in	IN
cord-002248-92pzqj35	335	22	the	the	DT
cord-002248-92pzqj35	335	23	carboxy	carboxy	JJ
cord-002248-92pzqj35	335	24	-	-	HYPH
cord-002248-92pzqj35	335	25	terminus	terminus	NN
cord-002248-92pzqj35	336	1	The	the	DT
cord-002248-92pzqj35	336	2	carboxy	carboxy	JJ
cord-002248-92pzqj35	336	3	-	-	HYPH
cord-002248-92pzqj35	336	4	terminal	terminal	NN
cord-002248-92pzqj35	336	5	acidic	acidic	JJ
cord-002248-92pzqj35	336	6	domain	domain	NN
cord-002248-92pzqj35	336	7	of	of	IN
cord-002248-92pzqj35	336	8	Rift	Rift	NNP
cord-002248-92pzqj35	336	9	Valley	Valley	NNP
cord-002248-92pzqj35	336	10	Fever	Fever	NNP
cord-002248-92pzqj35	336	11	virus	virus	NN
cord-002248-92pzqj35	336	12	NSs	nss	NN
cord-002248-92pzqj35	336	13	protein	protein	NN
cord-002248-92pzqj35	336	14	is	be	VBZ
cord-002248-92pzqj35	336	15	essential	essential	JJ
cord-002248-92pzqj35	336	16	for	for	IN
cord-002248-92pzqj35	336	17	the	the	DT
cord-002248-92pzqj35	336	18	formation	formation	NN
cord-002248-92pzqj35	336	19	of	of	IN
cord-002248-92pzqj35	336	20	filamentous	filamentous	JJ
cord-002248-92pzqj35	336	21	structures	structure	NNS
cord-002248-92pzqj35	336	22	but	but	CC
cord-002248-92pzqj35	336	23	not	not	RB
cord-002248-92pzqj35	336	24	for	for	IN
cord-002248-92pzqj35	336	25	the	the	DT
cord-002248-92pzqj35	336	26	nuclear	nuclear	JJ
cord-002248-92pzqj35	336	27	localization	localization	NN
cord-002248-92pzqj35	336	28	of	of	IN
cord-002248-92pzqj35	336	29	the	the	DT
cord-002248-92pzqj35	336	30	protein	protein	NN
cord-002248-92pzqj35	337	1	A	a	DT
cord-002248-92pzqj35	337	2	SAP30	SAP30	NNP
cord-002248-92pzqj35	337	3	complex	complex	NN
cord-002248-92pzqj35	337	4	inhibits	inhibit	VBZ
cord-002248-92pzqj35	337	5	IFNbeta	ifnbeta	JJ
cord-002248-92pzqj35	337	6	expression	expression	NN
cord-002248-92pzqj35	337	7	in	in	IN
cord-002248-92pzqj35	337	8	Rift	Rift	NNP
cord-002248-92pzqj35	337	9	Valley	Valley	NNP
cord-002248-92pzqj35	337	10	fever	fever	NN
cord-002248-92pzqj35	337	11	virus	virus	NN
cord-002248-92pzqj35	337	12	infected	infect	VBN
cord-002248-92pzqj35	337	13	cells	cell	NNS
cord-002248-92pzqj35	337	14	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	337	15	transcription	transcription	NN
cord-002248-92pzqj35	337	16	factor	factor	NN
cord-002248-92pzqj35	337	17	,	,	,
cord-002248-92pzqj35	337	18	a	a	DT
cord-002248-92pzqj35	337	19	target	target	NN
cord-002248-92pzqj35	337	20	for	for	IN
cord-002248-92pzqj35	337	21	the	the	DT
cord-002248-92pzqj35	337	22	Rift	Rift	NNP
cord-002248-92pzqj35	337	23	Valley	Valley	NNP
cord-002248-92pzqj35	337	24	hemorrhagic	hemorrhagic	JJ
cord-002248-92pzqj35	337	25	fever	fever	NN
cord-002248-92pzqj35	337	26	virus	virus	NN
cord-002248-92pzqj35	337	27	NSs	nss	NN
cord-002248-92pzqj35	337	28	protein	protein	NN
cord-002248-92pzqj35	337	29	of	of	IN
cord-002248-92pzqj35	337	30	rift	rift	NNP
cord-002248-92pzqj35	337	31	valley	valley	NNP
cord-002248-92pzqj35	337	32	fever	fever	NN
cord-002248-92pzqj35	337	33	virus	virus	NN
cord-002248-92pzqj35	338	1	promotes	promote	VBZ
cord-002248-92pzqj35	338	2	posttranslational	posttranslational	JJ
cord-002248-92pzqj35	338	3	downregulation	downregulation	NN
cord-002248-92pzqj35	338	4	of	of	IN
cord-002248-92pzqj35	338	5	the	the	DT
cord-002248-92pzqj35	338	6	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	338	7	subunit	subunit	NN
cord-002248-92pzqj35	338	8	p62	p62	NN
cord-002248-92pzqj35	338	9	Virulence	Virulence	NNP
cord-002248-92pzqj35	338	10	factor	factor	NN
cord-002248-92pzqj35	338	11	NSs	ns	NNS
cord-002248-92pzqj35	338	12	of	of	IN
cord-002248-92pzqj35	338	13	rift	rift	NNP
cord-002248-92pzqj35	338	14	valley	valley	NNP
cord-002248-92pzqj35	338	15	fever	fever	NNP
cord-002248-92pzqj35	338	16	virus	virus	NN
cord-002248-92pzqj35	338	17	recruits	recruit	VBZ
cord-002248-92pzqj35	338	18	the	the	DT
cord-002248-92pzqj35	338	19	F	F	NNP
cord-002248-92pzqj35	338	20	-	-	HYPH
cord-002248-92pzqj35	338	21	box	box	NNP
cord-002248-92pzqj35	338	22	protein	protein	NN
cord-002248-92pzqj35	338	23	FBXO3	fbxo3	RB
cord-002248-92pzqj35	338	24	to	to	TO
cord-002248-92pzqj35	338	25	degrade	degrade	VB
cord-002248-92pzqj35	338	26	subunit	subunit	NN
cord-002248-92pzqj35	338	27	p62	p62	NN
cord-002248-92pzqj35	338	28	of	of	IN
cord-002248-92pzqj35	338	29	general	general	JJ
cord-002248-92pzqj35	338	30	transcription	transcription	NN
cord-002248-92pzqj35	338	31	factor	factor	NN
cord-002248-92pzqj35	339	1	TFIIH	TFIIH	NNP
cord-002248-92pzqj35	339	2	Rift	Rift	NNP
cord-002248-92pzqj35	339	3	Valley	Valley	NNP
cord-002248-92pzqj35	339	4	fever	fever	NN
cord-002248-92pzqj35	339	5	virus	virus	NN
cord-002248-92pzqj35	339	6	NSs	NSs	NNP
cord-002248-92pzqj35	339	7	protein	protein	NN
cord-002248-92pzqj35	339	8	promotes	promote	VBZ
cord-002248-92pzqj35	339	9	post	post	JJ
cord-002248-92pzqj35	339	10	-	-	JJ
cord-002248-92pzqj35	339	11	transcriptional	transcriptional	JJ
cord-002248-92pzqj35	339	12	downregulation	downregulation	NN
cord-002248-92pzqj35	339	13	of	of	IN
cord-002248-92pzqj35	339	14	protein	protein	NN
cord-002248-92pzqj35	339	15	kinase	kinase	VBZ
cord-002248-92pzqj35	339	16	PKR	PKR	NNP
cord-002248-92pzqj35	339	17	and	and	CC
cord-002248-92pzqj35	339	18	inhibits	inhibit	VBZ
cord-002248-92pzqj35	339	19	eIF2alpha	eif2alpha	JJ
cord-002248-92pzqj35	339	20	phosphorylation	phosphorylation	NN
cord-002248-92pzqj35	339	21	NSs	NSs	NNP
cord-002248-92pzqj35	339	22	protein	protein	NN
cord-002248-92pzqj35	339	23	of	of	IN
cord-002248-92pzqj35	339	24	rift	rift	NNP
cord-002248-92pzqj35	339	25	valley	valley	NNP
cord-002248-92pzqj35	339	26	fever	fever	NNP
cord-002248-92pzqj35	339	27	virus	virus	NN
cord-002248-92pzqj35	339	28	induces	induce	VBZ
cord-002248-92pzqj35	339	29	the	the	DT
cord-002248-92pzqj35	339	30	specific	specific	JJ
cord-002248-92pzqj35	339	31	degradation	degradation	NN
cord-002248-92pzqj35	339	32	of	of	IN
cord-002248-92pzqj35	339	33	the	the	DT
cord-002248-92pzqj35	339	34	double	double	RB
cord-002248-92pzqj35	339	35	-	-	HYPH
cord-002248-92pzqj35	339	36	stranded	strand	VBN
cord-002248-92pzqj35	339	37	RNA	rna	NN
cord-002248-92pzqj35	339	38	-	-	HYPH
cord-002248-92pzqj35	339	39	dependent	dependent	JJ
cord-002248-92pzqj35	339	40	protein	protein	NN
cord-002248-92pzqj35	339	41	kinase	kinase	VBZ
cord-002248-92pzqj35	339	42	Protein	Protein	NNP
cord-002248-92pzqj35	339	43	Kinase	Kinase	NNP
cord-002248-92pzqj35	339	44	R	r	NN
cord-002248-92pzqj35	339	45	Degradation	degradation	NN
cord-002248-92pzqj35	339	46	Is	be	VBZ
cord-002248-92pzqj35	339	47	Essential	essential	JJ
cord-002248-92pzqj35	339	48	for	for	IN
cord-002248-92pzqj35	339	49	Rift	Rift	NNP
cord-002248-92pzqj35	339	50	Valley	Valley	NNP
cord-002248-92pzqj35	339	51	Fever	Fever	NNP
cord-002248-92pzqj35	339	52	Virus	Virus	NNP
cord-002248-92pzqj35	339	53	Infection	infection	NN
cord-002248-92pzqj35	339	54	and	and	CC
cord-002248-92pzqj35	339	55	Is	be	VBZ
cord-002248-92pzqj35	339	56	Regulated	regulate	VBN
cord-002248-92pzqj35	339	57	by	by	IN
cord-002248-92pzqj35	339	58	SKP1-CUL1-F	SKP1-CUL1-F	NNP
cord-002248-92pzqj35	339	59	-	-	HYPH
cord-002248-92pzqj35	339	60	box	box	NN
cord-002248-92pzqj35	339	61	(	(	-LRB-
cord-002248-92pzqj35	339	62	SCF	SCF	NNP
cord-002248-92pzqj35	339	63	)	)	-RRB-
cord-002248-92pzqj35	339	64	FBXW11-NSs	FBXW11-NSs	NNP
cord-002248-92pzqj35	340	1	E3	E3	NNP
cord-002248-92pzqj35	340	2	Ligase	Ligase	NNP
cord-002248-92pzqj35	340	3	NSs	NSs	NNP
cord-002248-92pzqj35	340	4	virulence	virulence	NN
cord-002248-92pzqj35	340	5	factor	factor	NN
cord-002248-92pzqj35	340	6	of	of	IN
cord-002248-92pzqj35	340	7	Rift	Rift	NNP
cord-002248-92pzqj35	340	8	Valley	Valley	NNP
cord-002248-92pzqj35	340	9	fever	fever	NN
cord-002248-92pzqj35	340	10	virus	virus	NN
cord-002248-92pzqj35	340	11	engages	engage	VBZ
cord-002248-92pzqj35	340	12	the	the	DT
cord-002248-92pzqj35	340	13	F	F	NNP
cord-002248-92pzqj35	340	14	-	-	HYPH
cord-002248-92pzqj35	340	15	box	box	NN
cord-002248-92pzqj35	340	16	proteins	protein	NNS
cord-002248-92pzqj35	341	1	FBXW11	fbxw11	NN
cord-002248-92pzqj35	341	2	and	and	CC
cord-002248-92pzqj35	341	3	beta	beta	NN
cord-002248-92pzqj35	341	4	-	-	HYPH
cord-002248-92pzqj35	341	5	TRCP1	trcp1	JJ
cord-002248-92pzqj35	342	1	to	to	TO
cord-002248-92pzqj35	342	2	degrade	degrade	VB
cord-002248-92pzqj35	342	3	the	the	DT
cord-002248-92pzqj35	342	4	antiviral	antiviral	JJ
cord-002248-92pzqj35	342	5	protein	protein	NN
cord-002248-92pzqj35	342	6	kinase	kinase	VBZ
cord-002248-92pzqj35	342	7	PKR	PKR	NNP
cord-002248-92pzqj35	342	8	Reactive	reactive	JJ
cord-002248-92pzqj35	342	9	oxygen	oxygen	NN
cord-002248-92pzqj35	342	10	species	specie	NNS
cord-002248-92pzqj35	342	11	activate	activate	VBP
cord-002248-92pzqj35	342	12	NFkappaB	NFkappaB	NNP
cord-002248-92pzqj35	342	13	(	(	-LRB-
cord-002248-92pzqj35	342	14	p65	p65	NN
cord-002248-92pzqj35	342	15	)	)	-RRB-
cord-002248-92pzqj35	342	16	and	and	CC
cord-002248-92pzqj35	342	17	p53	p53	NN
cord-002248-92pzqj35	342	18	and	and	CC
cord-002248-92pzqj35	342	19	induce	induce	VB
cord-002248-92pzqj35	343	1	apoptosis	apoptosis	NN
cord-002248-92pzqj35	343	2	in	in	IN
cord-002248-92pzqj35	343	3	RVFV	RVFV	NNP
cord-002248-92pzqj35	343	4	infected	infected	JJ
cord-002248-92pzqj35	343	5	liver	liver	NN
cord-002248-92pzqj35	343	6	cells	cell	NNS
cord-002248-92pzqj35	344	1	Induction	induction	NN
cord-002248-92pzqj35	344	2	of	of	IN
cord-002248-92pzqj35	344	3	DNA	dna	NN
cord-002248-92pzqj35	344	4	damage	damage	NN
cord-002248-92pzqj35	344	5	signaling	signaling	NN
cord-002248-92pzqj35	344	6	upon	upon	IN
cord-002248-92pzqj35	344	7	Rift	Rift	NNP
cord-002248-92pzqj35	344	8	Valley	Valley	NNP
cord-002248-92pzqj35	344	9	fever	fever	NN
cord-002248-92pzqj35	344	10	virus	virus	NN
cord-002248-92pzqj35	344	11	infection	infection	NN
cord-002248-92pzqj35	344	12	results	result	VBZ
cord-002248-92pzqj35	344	13	in	in	IN
cord-002248-92pzqj35	344	14	cell	cell	NN
cord-002248-92pzqj35	344	15	cycle	cycle	NN
cord-002248-92pzqj35	344	16	arrest	arrest	NN
cord-002248-92pzqj35	344	17	and	and	CC
cord-002248-92pzqj35	344	18	increased	increase	VBN
cord-002248-92pzqj35	344	19	viral	viral	JJ
cord-002248-92pzqj35	344	20	replication	replication	NN
cord-002248-92pzqj35	344	21	p53	p53	NN
cord-002248-92pzqj35	344	22	Activation	Activation	NNP
cord-002248-92pzqj35	344	23	following	follow	VBG
cord-002248-92pzqj35	344	24	Rift	Rift	NNP
cord-002248-92pzqj35	344	25	Valley	Valley	NNP
cord-002248-92pzqj35	344	26	fever	fever	NN
cord-002248-92pzqj35	344	27	virus	virus	NN
cord-002248-92pzqj35	344	28	infection	infection	NN
cord-002248-92pzqj35	344	29	contributes	contribute	VBZ
cord-002248-92pzqj35	344	30	to	to	IN
cord-002248-92pzqj35	344	31	cell	cell	NN
cord-002248-92pzqj35	344	32	death	death	NN
cord-002248-92pzqj35	344	33	and	and	CC
cord-002248-92pzqj35	344	34	viral	viral	JJ
cord-002248-92pzqj35	344	35	production	production	NN
cord-002248-92pzqj35	344	36	Nonstructural	nonstructural	JJ
cord-002248-92pzqj35	344	37	NSs	NSs	NNP
cord-002248-92pzqj35	344	38	protein	protein	NN
cord-002248-92pzqj35	344	39	of	of	IN
cord-002248-92pzqj35	344	40	rift	rift	NNP
cord-002248-92pzqj35	344	41	valley	valley	NNP
cord-002248-92pzqj35	344	42	fever	fever	NN
cord-002248-92pzqj35	344	43	virus	virus	NN
cord-002248-92pzqj35	344	44	interacts	interact	VBZ
cord-002248-92pzqj35	344	45	with	with	IN
cord-002248-92pzqj35	344	46	pericentromeric	pericentromeric	JJ
cord-002248-92pzqj35	344	47	DNA	DNA	NNP
cord-002248-92pzqj35	344	48	sequences	sequence	NNS
cord-002248-92pzqj35	344	49	of	of	IN
cord-002248-92pzqj35	344	50	the	the	DT
cord-002248-92pzqj35	344	51	host	host	NN
cord-002248-92pzqj35	344	52	cell	cell	NN
cord-002248-92pzqj35	344	53	,	,	,
cord-002248-92pzqj35	344	54	inducing	induce	VBG
cord-002248-92pzqj35	344	55	chromosome	chromosome	NN
cord-002248-92pzqj35	344	56	cohesion	cohesion	NN
cord-002248-92pzqj35	344	57	and	and	CC
cord-002248-92pzqj35	344	58	segregation	segregation	NN
cord-002248-92pzqj35	344	59	defects	defect	NNS
cord-002248-92pzqj35	344	60	Functional	functional	JJ
cord-002248-92pzqj35	344	61	analysis	analysis	NN
cord-002248-92pzqj35	344	62	of	of	IN
cord-002248-92pzqj35	344	63	Rift	Rift	NNP
cord-002248-92pzqj35	344	64	Valley	Valley	NNP
cord-002248-92pzqj35	344	65	fever	fever	NN
cord-002248-92pzqj35	344	66	virus	virus	NN
cord-002248-92pzqj35	344	67	NSs	ns	NNS
cord-002248-92pzqj35	344	68	encoding	encode	VBG
cord-002248-92pzqj35	344	69	a	a	DT
cord-002248-92pzqj35	344	70	partial	partial	JJ
cord-002248-92pzqj35	344	71	truncation	truncation	NN
cord-002248-92pzqj35	344	72	Rescue	Rescue	NNP
cord-002248-92pzqj35	344	73	of	of	IN
cord-002248-92pzqj35	344	74	infectious	infectious	JJ
cord-002248-92pzqj35	344	75	rift	rift	NNP
cord-002248-92pzqj35	344	76	valley	valley	NNP
cord-002248-92pzqj35	344	77	fever	fever	NN
cord-002248-92pzqj35	344	78	virus	virus	NN
cord-002248-92pzqj35	344	79	entirely	entirely	RB
cord-002248-92pzqj35	344	80	from	from	IN
cord-002248-92pzqj35	344	81	cDNA	cdna	NN
cord-002248-92pzqj35	344	82	,	,	,
cord-002248-92pzqj35	344	83	analysis	analysis	NN
cord-002248-92pzqj35	344	84	of	of	IN
cord-002248-92pzqj35	344	85	virus	virus	NN
cord-002248-92pzqj35	344	86	lacking	lack	VBG
cord-002248-92pzqj35	344	87	the	the	DT
cord-002248-92pzqj35	344	88	NSs	NSs	NNP
cord-002248-92pzqj35	344	89	gene	gene	NN
cord-002248-92pzqj35	344	90	,	,	,
cord-002248-92pzqj35	344	91	and	and	CC
cord-002248-92pzqj35	344	92	expression	expression	NN
cord-002248-92pzqj35	344	93	of	of	IN
cord-002248-92pzqj35	344	94	a	a	DT
cord-002248-92pzqj35	344	95	foreign	foreign	JJ
cord-002248-92pzqj35	344	96	gene	gene	NN
cord-002248-92pzqj35	344	97	Generation	generation	NN
cord-002248-92pzqj35	344	98	of	of	IN
cord-002248-92pzqj35	344	99	bovine	bovine	JJ
cord-002248-92pzqj35	344	100	respiratory	respiratory	JJ
cord-002248-92pzqj35	344	101	syncytial	syncytial	JJ
cord-002248-92pzqj35	344	102	virus	virus	NN
cord-002248-92pzqj35	344	103	(	(	-LRB-
cord-002248-92pzqj35	344	104	BRSV	BRSV	NNP
cord-002248-92pzqj35	344	105	)	)	-RRB-
cord-002248-92pzqj35	344	106	from	from	IN
cord-002248-92pzqj35	344	107	cDNA	cdna	NN
cord-002248-92pzqj35	344	108	:	:	:
cord-002248-92pzqj35	345	1	BRSV	BRSV	NNP
cord-002248-92pzqj35	345	2	NS2	NS2	NNP
cord-002248-92pzqj35	345	3	is	be	VBZ
cord-002248-92pzqj35	345	4	not	not	RB
cord-002248-92pzqj35	345	5	essential	essential	JJ
cord-002248-92pzqj35	345	6	for	for	IN
cord-002248-92pzqj35	345	7	virus	virus	NN
cord-002248-92pzqj35	345	8	replication	replication	NN
cord-002248-92pzqj35	345	9	in	in	IN
cord-002248-92pzqj35	345	10	tissue	tissue	NN
cord-002248-92pzqj35	345	11	culture	culture	NN
cord-002248-92pzqj35	345	12	,	,	,
cord-002248-92pzqj35	345	13	and	and	CC
cord-002248-92pzqj35	345	14	the	the	DT
cord-002248-92pzqj35	345	15	human	human	JJ
cord-002248-92pzqj35	345	16	RSV	RSV	NNP
cord-002248-92pzqj35	345	17	leader	leader	NN
cord-002248-92pzqj35	345	18	region	region	NN
cord-002248-92pzqj35	345	19	acts	act	VBZ
cord-002248-92pzqj35	345	20	as	as	IN
cord-002248-92pzqj35	345	21	a	a	DT
cord-002248-92pzqj35	345	22	functional	functional	JJ
cord-002248-92pzqj35	345	23	BRSV	BRSV	NNP
cord-002248-92pzqj35	345	24	genome	genome	NN
cord-002248-92pzqj35	345	25	promoter	promoter	NN
cord-002248-92pzqj35	345	26	Mutagen	Mutagen	NNP
cord-002248-92pzqj35	345	27	-	-	HYPH
cord-002248-92pzqj35	345	28	directed	direct	VBN
cord-002248-92pzqj35	345	29	attenuation	attenuation	NN
cord-002248-92pzqj35	345	30	of	of	IN
cord-002248-92pzqj35	345	31	Rift	Rift	NNP
cord-002248-92pzqj35	345	32	Valley	Valley	NNP
cord-002248-92pzqj35	345	33	fever	fever	NN
cord-002248-92pzqj35	345	34	virus	virus	NN
cord-002248-92pzqj35	345	35	as	as	IN
cord-002248-92pzqj35	345	36	a	a	DT
cord-002248-92pzqj35	345	37	method	method	NN
cord-002248-92pzqj35	345	38	for	for	IN
cord-002248-92pzqj35	345	39	vaccine	vaccine	NN
cord-002248-92pzqj35	345	40	development	development	NN
cord-002248-92pzqj35	345	41	NIH	NIH	NNP
cord-002248-92pzqj35	345	42	Image	image	NN
cord-002248-92pzqj35	345	43	to	to	IN
cord-002248-92pzqj35	345	44	ImageJ	imagej	NN
cord-002248-92pzqj35	345	45	:	:	:
cord-002248-92pzqj35	345	46	25	25	CD
cord-002248-92pzqj35	345	47	years	year	NNS
cord-002248-92pzqj35	345	48	of	of	IN
cord-002248-92pzqj35	345	49	image	image	NN
cord-002248-92pzqj35	345	50	analysis	analysis	NN
cord-002248-92pzqj35	345	51	Rift	Rift	NNP
cord-002248-92pzqj35	345	52	valley	valley	NNP
cord-002248-92pzqj35	345	53	fever	fever	NN
cord-002248-92pzqj35	345	54	virus	virus	NN
cord-002248-92pzqj35	345	55	nonstructural	nonstructural	JJ
cord-002248-92pzqj35	345	56	protein	protein	NN
cord-002248-92pzqj35	345	57	NSs	NSs	NNP
cord-002248-92pzqj35	345	58	promotes	promote	VBZ
cord-002248-92pzqj35	345	59	viral	viral	JJ
cord-002248-92pzqj35	345	60	RNA	RNA	NNP
cord-002248-92pzqj35	345	61	replication	replication	NN
cord-002248-92pzqj35	345	62	and	and	CC
cord-002248-92pzqj35	345	63	transcription	transcription	NN
cord-002248-92pzqj35	345	64	in	in	IN
cord-002248-92pzqj35	345	65	a	a	DT
cord-002248-92pzqj35	345	66	minigenome	minigenome	NN
cord-002248-92pzqj35	345	67	system	system	NN
cord-002248-92pzqj35	346	1	Severe	severe	JJ
cord-002248-92pzqj35	346	2	acute	acute	JJ
cord-002248-92pzqj35	346	3	respiratory	respiratory	JJ
cord-002248-92pzqj35	346	4	syndrome	syndrome	NN
cord-002248-92pzqj35	346	5	coronavirus	coronavirus	NN
cord-002248-92pzqj35	346	6	nsp1	nsp1	CD
cord-002248-92pzqj35	346	7	suppresses	suppress	VBZ
cord-002248-92pzqj35	346	8	host	host	NN
cord-002248-92pzqj35	346	9	gene	gene	NN
cord-002248-92pzqj35	346	10	expression	expression	NN
cord-002248-92pzqj35	346	11	,	,	,
cord-002248-92pzqj35	346	12	including	include	VBG
cord-002248-92pzqj35	346	13	that	that	DT
cord-002248-92pzqj35	346	14	of	of	IN
cord-002248-92pzqj35	346	15	type	type	NN
cord-002248-92pzqj35	347	1	I	-PRON-	PRP
cord-002248-92pzqj35	347	2	interferon	interferon	VBD
cord-002248-92pzqj35	347	3	,	,	,
cord-002248-92pzqj35	347	4	in	in	IN
cord-002248-92pzqj35	347	5	infected	infected	JJ
cord-002248-92pzqj35	347	6	cells	cell	NNS
cord-002248-92pzqj35	347	7	Mechanism	Mechanism	NNP
cord-002248-92pzqj35	347	8	of	of	IN
cord-002248-92pzqj35	347	9	tripartite	tripartite	JJ
cord-002248-92pzqj35	347	10	RNA	RNA	NNP
cord-002248-92pzqj35	347	11	genome	genome	NN
cord-002248-92pzqj35	347	12	packaging	packaging	NN
cord-002248-92pzqj35	347	13	in	in	IN
cord-002248-92pzqj35	347	14	Rift	Rift	NNP
cord-002248-92pzqj35	347	15	Valley	Valley	NNP
cord-002248-92pzqj35	347	16	fever	fever	NN
cord-002248-92pzqj35	347	17	virus	virus	NN
cord-002248-92pzqj35	347	18	Characterization	characterization	NN
cord-002248-92pzqj35	347	19	of	of	IN
cord-002248-92pzqj35	347	20	clone	clone	NN
cord-002248-92pzqj35	347	21	13	13	CD
cord-002248-92pzqj35	347	22	,	,	,
cord-002248-92pzqj35	347	23	a	a	DT
cord-002248-92pzqj35	347	24	naturally	naturally	RB
cord-002248-92pzqj35	347	25	attenuated	attenuate	VBN
cord-002248-92pzqj35	347	26	avirulent	avirulent	NN
cord-002248-92pzqj35	347	27	isolate	isolate	NN
cord-002248-92pzqj35	347	28	of	of	IN
cord-002248-92pzqj35	347	29	Rift	Rift	NNP
cord-002248-92pzqj35	347	30	Valley	Valley	NNP
cord-002248-92pzqj35	347	31	fever	fever	NN
cord-002248-92pzqj35	347	32	virus	virus	NN
cord-002248-92pzqj35	347	33	,	,	,
cord-002248-92pzqj35	347	34	which	which	WDT
cord-002248-92pzqj35	347	35	is	be	VBZ
cord-002248-92pzqj35	347	36	altered	alter	VBN
cord-002248-92pzqj35	347	37	in	in	IN
cord-002248-92pzqj35	347	38	the	the	DT
cord-002248-92pzqj35	347	39	small	small	JJ
cord-002248-92pzqj35	347	40	segment	segment	NN
cord-002248-92pzqj35	347	41	A	A	NNP
cord-002248-92pzqj35	347	42	ΩXaV	ΩXaV	NNP
cord-002248-92pzqj35	347	43	motif	motif	NN
cord-002248-92pzqj35	347	44	in	in	IN
cord-002248-92pzqj35	347	45	the	the	DT
cord-002248-92pzqj35	347	46	Rift	Rift	NNP
cord-002248-92pzqj35	347	47	Valley	Valley	NNP
cord-002248-92pzqj35	347	48	fever	fever	NN
cord-002248-92pzqj35	347	49	virus	virus	NN
cord-002248-92pzqj35	347	50	NSs	nss	NN
cord-002248-92pzqj35	347	51	protein	protein	NN
cord-002248-92pzqj35	347	52	is	be	VBZ
cord-002248-92pzqj35	347	53	essential	essential	JJ
cord-002248-92pzqj35	347	54	for	for	IN
cord-002248-92pzqj35	347	55	degrading	degrade	VBG
cord-002248-92pzqj35	347	56	p62	p62	NN
cord-002248-92pzqj35	347	57	,	,	,
cord-002248-92pzqj35	347	58	forming	form	VBG
cord-002248-92pzqj35	347	59	nuclear	nuclear	JJ
cord-002248-92pzqj35	347	60	filaments	filament	NNS
cord-002248-92pzqj35	347	61	and	and	CC
cord-002248-92pzqj35	348	1	virulence	virulence	NN
cord-002248-92pzqj35	348	2	Recombinant	Recombinant	NNP
cord-002248-92pzqj35	348	3	Rift	Rift	NNP
cord-002248-92pzqj35	348	4	Valley	Valley	NNP
cord-002248-92pzqj35	348	5	fever	fever	NN
cord-002248-92pzqj35	348	6	vaccines	vaccine	NNS
cord-002248-92pzqj35	348	7	induce	induce	VBP
cord-002248-92pzqj35	348	8	protective	protective	JJ
cord-002248-92pzqj35	348	9	levels	level	NNS
cord-002248-92pzqj35	348	10	of	of	IN
cord-002248-92pzqj35	348	11	antibody	antibody	NN
cord-002248-92pzqj35	348	12	in	in	IN
cord-002248-92pzqj35	348	13	baboons	baboon	NNS
cord-002248-92pzqj35	348	14	and	and	CC
cord-002248-92pzqj35	348	15	resistance	resistance	NN
cord-002248-92pzqj35	348	16	to	to	IN
cord-002248-92pzqj35	348	17	lethal	lethal	JJ
cord-002248-92pzqj35	348	18	challenge	challenge	NN
cord-002248-92pzqj35	348	19	in	in	IN
cord-002248-92pzqj35	348	20	mice	mouse	NNS
cord-002248-92pzqj35	349	1	Interplay	interplay	NN
cord-002248-92pzqj35	349	2	between	between	IN
cord-002248-92pzqj35	349	3	the	the	DT
cord-002248-92pzqj35	349	4	Virus	Virus	NNP
cord-002248-92pzqj35	349	5	and	and	CC
cord-002248-92pzqj35	349	6	Host	Host	NNP
cord-002248-92pzqj35	349	7	in	in	IN
cord-002248-92pzqj35	349	8	Rift	Rift	NNP
cord-002248-92pzqj35	349	9	Valley	Valley	NNP
cord-002248-92pzqj35	349	10	Fever	Fever	NNP
cord-002248-92pzqj35	349	11	Pathogenesis	Pathogenesis	NNP
cord-002248-92pzqj35	349	12	Host	Host	NNP
cord-002248-92pzqj35	349	13	alternation	alternation	NN
cord-002248-92pzqj35	349	14	is	be	VBZ
cord-002248-92pzqj35	349	15	necessary	necessary	JJ
cord-002248-92pzqj35	349	16	to	to	TO
cord-002248-92pzqj35	349	17	maintain	maintain	VB
cord-002248-92pzqj35	349	18	the	the	DT
cord-002248-92pzqj35	349	19	genome	genome	NN
cord-002248-92pzqj35	349	20	stability	stability	NN
cord-002248-92pzqj35	349	21	of	of	IN
cord-002248-92pzqj35	349	22	rift	rift	NNP
cord-002248-92pzqj35	349	23	valley	valley	NNP
cord-002248-92pzqj35	349	24	fever	fever	NN
cord-002248-92pzqj35	349	25	virus	virus	NN
cord-002248-92pzqj35	350	1	We	-PRON-	PRP
cord-002248-92pzqj35	350	2	thank	thank	VBP
cord-002248-92pzqj35	350	3	Robert	Robert	NNP
cord-002248-92pzqj35	350	4	Tesh	Tesh	NNP
cord-002248-92pzqj35	350	5	for	for	IN
cord-002248-92pzqj35	350	6	anti	anti	JJ
cord-002248-92pzqj35	350	7	-	-	JJ
cord-002248-92pzqj35	350	8	MP12	mp12	JJ
cord-002248-92pzqj35	350	9	antibody	antibody	NN
cord-002248-92pzqj35	350	10	;	;	:
cord-002248-92pzqj35	350	11	Paul	Paul	NNP
cord-002248-92pzqj35	350	12	Gottlieb	Gottlieb	NNP
cord-002248-92pzqj35	350	13	for	for	IN
cord-002248-92pzqj35	350	14	the	the	DT
cord-002248-92pzqj35	350	15	monoclonal	monoclonal	JJ
cord-002248-92pzqj35	350	16	antibody	antibody	NN
cord-002248-92pzqj35	350	17	H2	h2	NN
cord-002248-92pzqj35	350	18	K	K	NNP
cord-002248-92pzqj35	350	19	k	k	NN
cord-002248-92pzqj35	350	20	D	d	NN
cord-002248-92pzqj35	350	21	k	k	NN
cord-002248-92pzqj35	350	22	;	;	:
cord-002248-92pzqj35	350	23	Mark	Mark	NNP
cord-002248-92pzqj35	350	24	Griffin	Griffin	NNP
cord-002248-92pzqj35	350	25	(	(	-LRB-
cord-002248-92pzqj35	350	26	Flow	flow	VB
cord-002248-92pzqj35	350	27	Cytometry	Cytometry	NNP
cord-002248-92pzqj35	350	28	and	and	CC
cord-002248-92pzqj35	350	29	Cell	Cell	NNP
cord-002248-92pzqj35	350	30	Sorting	Sorting	NNP
cord-002248-92pzqj35	350	31	Core	Core	NNP
cord-002248-92pzqj35	350	32	,	,	,
cord-002248-92pzqj35	350	33	The	the	DT
cord-002248-92pzqj35	350	34	University	University	NNP
cord-002248-92pzqj35	350	35	of	of	IN
cord-002248-92pzqj35	350	36	Texas	Texas	NNP
cord-002248-92pzqj35	350	37	Medical	Medical	NNP
cord-002248-92pzqj35	350	38	Branch	Branch	NNP
cord-002248-92pzqj35	350	39	)	)	-RRB-
cord-002248-92pzqj35	350	40	for	for	IN
cord-002248-92pzqj35	350	41	support	support	NN
cord-002248-92pzqj35	350	42	with	with	IN
cord-002248-92pzqj35	350	43	the	the	DT
cord-002248-92pzqj35	350	44	flow	flow	NN
cord-002248-92pzqj35	350	45	cytometry	cytometry	NN
cord-002248-92pzqj35	350	46	analyses	analysis	NNS
cord-002248-92pzqj35	350	47	;	;	:
cord-002248-92pzqj35	350	48	and	and	CC
cord-002248-92pzqj35	350	49	Krishna	Krishna	NNP
cord-002248-92pzqj35	350	50	Narayanan	Narayanan	NNP
cord-002248-92pzqj35	350	51	for	for	IN
cord-002248-92pzqj35	350	52	critical	critical	JJ
cord-002248-92pzqj35	350	53	reading	reading	NN
cord-002248-92pzqj35	350	54	of	of	IN
cord-002248-92pzqj35	350	55	the	the	DT
cord-002248-92pzqj35	350	56	manuscript	manuscript	NN
cord-002248-92pzqj35	350	57	.	.	.
cord-002248-92pzqj35	351	1	Conceptualization	conceptualization	NN
cord-002248-92pzqj35	351	2	:	:	:
cord-002248-92pzqj35	351	3	KT	KT	NNP
cord-002248-92pzqj35	351	4	SM	SM	NNP
cord-002248-92pzqj35	351	5	.	.	.
cord-002248-92pzqj35	351	6	 	 	_SP