id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000127-tkxpjlyn	Dermody, Terence S.	Immunoglobulin Superfamily Virus Receptors and the Evolution of Adaptive Immunity	2009-11-26		.txt	text/plain	2332	115	36	The immunoglobulin superfamily (IgSF) of molecules contains several members that are expressed at the cell surface, bind diverse ligands, and contribute to a variety of cellular activities, including adhesion and immune responses. While structural information about com-plex formation is lacking for the IgSF receptors carcinoembryonic antigen-related cell adhesion molecule, nectin-1, nectin-2, and signaling lymphocyte-activation molecule (SLAM), biochemical studies also implicate their respective D1 domains in virus binding [11] [12] [13] [14] . The evolution of JAM family members prior to the biochemical means to efficiently and extensively diversify antigen receptor genes, along with the structural similarities in the binding surfaces of virus receptors and immunoglobulins, provides strong support for the contention that viruses and perhaps other pathogens that engage IgSF receptors contributed to the selection of humoral mediators of adaptive immunity.	./cache/cord-000127-tkxpjlyn.txt	./txt/cord-000127-tkxpjlyn.txt