id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000164-094d0rn6	Suthar, Mehul S.	IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity	2010-02-05		.txt	text/plain	8172	340	44	Infection of cultured bone-marrow (BM) derived dendritic cells (DCs), macrophages (Macs), and primary cortical neurons showed that the IPS-1-dependent RLR signaling was essential for triggering IFN defenses and controlling virus replication in these key target cells of infection. Intriguingly, infected IPS-1(−/−) mice displayed uncontrolled inflammation that included elevated systemic type I IFN, proinflammatory cytokine and chemokine responses, increased numbers of inflammatory DCs, enhanced humoral responses marked by complete loss of virus neutralization activity, and increased numbers of virus-specific CD8+ T cells and non-specific immune cell proliferation in the periphery and in the CNS. To define the role of IPS-1 in controlling virus replication and innate immunity in myeloid cells, we analyzed WNV infection and host responses in primary bone marrow-derived DC and Mw recovered from wild type and IPS-1 2/2 mice.	./cache/cord-000164-094d0rn6.txt	./txt/cord-000164-094d0rn6.txt