id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001636-khrx6rnh	Bordería, Antonio V.	Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype	2015-05-05		.txt	text/plain	7524	358	50	The total number of minority variants within the P1 structural coding region also significantly increased over the passage series (Fig 1G) , yet there were no significant differences between the numbers observed in Hela and A549 cell passage. The mutations that arise from adaptive passage map to receptor binding sites in a cell-type specific manner Although the HeLa and A549 cell passage series presented similar mean genetic diversity at passage 40 (Fig 1E-1G , P = 0.314), we mined the deep sequence data for all minority variants above 1% frequency that might explain adaptation in each condition (Table 1 ). Given the different frequencies of minority variants observed at passage 40, we examined the patterns of emergence and sequential adaptation to novel environments by deep sequencing every second passage in the A549 cell series (Fig 3 and S1 Dataset).	./cache/cord-001636-khrx6rnh.txt	./txt/cord-001636-khrx6rnh.txt