id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258234-qn8xp4v9	Striker, Rob	Inhibitors of Peptidyl Proline Isomerases As Antivirals in Hepatitis C and Other Viruses	2014-11-06		.txt	text/plain	2485	132	38	Cyclophilin inhibitors that reduce viral replication also block interactions between cyclophilin A and NS5A, suggesting that this association is important during the viral life cycle and might be the relevant target of the antiviral activity of cyclosporine [11] [12] [13] . HCV NS5A is a protein that is rich in both proline residues and disorder and that associates with cyclophilin A via domain 2. However, these regions share several common properties: the flexible cyclophilin-interacting loop in CA is also bracketed by prolines, just as the PAWARPDYNP motif in HCV; residues 86, 91, and 96 that surround the glycine-proline in CA influence viral susceptibility to cyclophillin inhibitors similar to mutations surrounding NS5A P319 [25] ; and the critical glycine-proline is amino-terminal to regions of CA that are actually more proline rich and predicted by bioinformatics analysis to be disordered, analogous to the positioning of the PAWARPDYNP motif in HCV NS5A.	./cache/cord-258234-qn8xp4v9.txt	./txt/cord-258234-qn8xp4v9.txt