id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262248-q5eijunp	Casadevall, Arturo	The Ebola Epidemic Crystallizes the Potential of Passive Antibody Therapy for Infectious Diseases	2015-04-23		.txt	text/plain	2631	118	37	Currently, there are no drugs to treat Ebola, but, in the urgency and emergency triggered by the epidemic, two types of Ab-based therapies have been used: convalescent sera from patients who have recovered and a mAb cocktail known as ZMapp produced in plants [3] . For example, given that there is increasing evidence that antibiotic-induced disruptions of the microbiota are associated with deleterious effects in the treatment of bacterial diseases, the high specificity of Ab-based therapies offers a tremendous advantage. Regarding the limitation that highly specific Abs can fail to bind highly related variants, particularly for viruses, there are two strategies to overcome this problem: the development of Abs that target broadly neutralizing epitopes, as has now been demonstrated for HIV [8] , dengue [9] , and influenza viruses [10] , and the generation of Ab cocktails composed of Abs against multiple serotypes or variants, as has been done for rabies virus [11] and Clostridium difficile toxin [12] .	./cache/cord-262248-q5eijunp.txt	./txt/cord-262248-q5eijunp.txt