id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266078-h53zpjab	McGuckin Wuertz, Kathryn	STING is required for host defense against neuropathological West Nile virus infection	2019-08-15		.txt	text/plain	9796	470	49	Recent studies indicate that STimulator of INterferon Gene (STING), canonically known for initiating a type I IFN production and innate immune response to cytosolic DNA, is required for host defense against neurotropic RNA viruses. In vivo, STING-/mice developed an aberrant T cell response in both the spleen and brain during WNV infection that linked with increased and sustained CNS pathology compared to WT mice. In the CNS however, we observed a trend toward increased viral RNA and innate immune gene expression at 8 dpi in WNV-infected STING-/-mice, similar to that observed in BMDM (Fig 3A and 3D) . These observations suggest that STING plays a role in directing or maintaining the T cell response to specific loci within the CNS or that initial viral infection led to increased STING is required for host defense against neuropathological West Nile virus infection recruitment of a localized adaptive immune response that resulted in immunopathology.	./cache/cord-266078-h53zpjab.txt	./txt/cord-266078-h53zpjab.txt