id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278511-je1509ar	Wang, David	5 challenges in understanding the role of the virome in health and disease	2020-03-26		.txt	text/plain	2166	107	38	An even more significant problem is that in most virome studies, more than 50% of the sequences in virus-enriched preparations have no detectable sequence similarity to any known reference sequences; these unalignable sequences are referred to as viral "dark matter" [8] and may include novel, highly divergent viruses that are unrecognizable. To illustrate this point, the United States National Institutes of Health (NIH) virology study sections address only "non-bacteriophage viral genetics, infection and replication, cellular and host responses to viral infections, and mechanisms of viral disease pathogenesis." Thus, there is a great need to bring these disparate communities together in order to collectively attack questions associated with the virome, especially as more complex trans-kingdom interactions are identified linking phages, bacteria, eukaryotic viruses, and eukaryotic cells. With new cell-culture systems and animal models for novel viruses, there will ideally be studies that attribute causal roles for some of the associations.	./cache/cord-278511-je1509ar.txt	./txt/cord-278511-je1509ar.txt