id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325624-6anybxnk	Ireland, Derek D. C.	RNase L Mediated Protection from Virus Induced Demyelination	2009-10-02		.txt	text/plain	8082	397	43	The unique phenotype of infected RL(−/−) mice was rather manifested in earlier onset and increased severity of demyelination and axonal damage in brain stem and spinal cord without evidence for enhanced neuronal infection. RNase L specifically protected the brain stem from sustained infection and prevented spread of virus to microglia/macrophages located in spinal cord grey matter. The increased pathological changes in both brain stem and spinal cord thus correlated with the high mortality rates of RL 2/2 mice starting at day 9 p.i. The inability to directly link increased axonal damage with enhanced neuronal infection remains puzzling and supports dysregulation of oligodendrocyte function and/or neuroprotective functions of microglia as contributing factors to the severe pathological phenotype and clinical outcome. Numerous functions of RNase L, not directly associated with anti-viral activity, may contribute to the increased susceptibility of RL 2/2 mice to MHV-JHM infection.	./cache/cord-325624-6anybxnk.txt	./txt/cord-325624-6anybxnk.txt