id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328947-3l9ydspz	Webb, L. G.	Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS	2020-10-15		.txt	text/plain	9857	544	51	CHIKV is no exception, the type-I interferon (IFN) response has been demonstrated to be key in controlling CHIKV infection [21] [22] [23] [24] [25] [26] and primary sensing of the virus is via the pattern recognition receptor (PRR) retinoic acid-inducible gene I (RIG-I)-mitochondrial antiviral signaling protein (MAVS) axis [24, 26] . The lack of cGAS degradation seen in the exogenous expression system when compared to the infected cells shows that although there is a clear interaction of cGAS with nsP4, the degradation of cGAS observed is not mediated by the non-structural proteins of CHIKV, but must require other viral or host factors. Chikungunya virus inhibits DNA sensing by degrading cGAS both mock and infected cells by 4 hpi suggesting that the stress produced during the process of infection (mock or CHIKV) in HFF-1s stimulates increased translation at early timepoints ( Fig 4D, lanes 2 and 5) .	./cache/cord-328947-3l9ydspz.txt	./txt/cord-328947-3l9ydspz.txt