id	sid	tid	token	lemma	pos
cord-001859-d62iuk72	1	1	key	key	JJ
cord-001859-d62iuk72	1	2	:	:	:
cord-001859-d62iuk72	1	3	cord-001859-d62iuk72	cord-001859-d62iuk72	CD
cord-001859-d62iuk72	1	4	authors	author	NNS
cord-001859-d62iuk72	1	5	:	:	:
cord-001859-d62iuk72	1	6	Baquero	Baquero	NNP
cord-001859-d62iuk72	1	7	-	-	HYPH
cord-001859-d62iuk72	1	8	Pérez	Pérez	NNP
cord-001859-d62iuk72	1	9	,	,	,
cord-001859-d62iuk72	1	10	Belinda	Belinda	NNP
cord-001859-d62iuk72	1	11	;	;	:
cord-001859-d62iuk72	1	12	Whitehouse	Whitehouse	NNP
cord-001859-d62iuk72	1	13	,	,	,
cord-001859-d62iuk72	1	14	Adrian	Adrian	NNP
cord-001859-d62iuk72	1	15	title	title	NN
cord-001859-d62iuk72	1	16	:	:	:
cord-001859-d62iuk72	2	1	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	2	2	Isoforms	Isoforms	NNP
cord-001859-d62iuk72	2	3	Are	be	VBP
cord-001859-d62iuk72	2	4	Essential	essential	JJ
cord-001859-d62iuk72	2	5	for	for	IN
cord-001859-d62iuk72	2	6	the	the	DT
cord-001859-d62iuk72	2	7	Formation	Formation	NNP
cord-001859-d62iuk72	2	8	of	of	IN
cord-001859-d62iuk72	2	9	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	2	10	’s	’s	POS
cord-001859-d62iuk72	2	11	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	2	12	-	-	HYPH
cord-001859-d62iuk72	2	13	Associated	Associated	NNP
cord-001859-d62iuk72	2	14	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	2	15	Replication	Replication	NNP
cord-001859-d62iuk72	2	16	and	and	CC
cord-001859-d62iuk72	2	17	Transcription	Transcription	NNP
cord-001859-d62iuk72	2	18	Compartments	Compartments	NNPS
cord-001859-d62iuk72	2	19	date	date	NN
cord-001859-d62iuk72	2	20	:	:	:
cord-001859-d62iuk72	2	21	2015	2015	CD
cord-001859-d62iuk72	2	22	-	-	SYM
cord-001859-d62iuk72	2	23	11	11	CD
cord-001859-d62iuk72	2	24	-	-	SYM
cord-001859-d62iuk72	2	25	20	20	CD
cord-001859-d62iuk72	2	26	journal	journal	NN
cord-001859-d62iuk72	2	27	:	:	:
cord-001859-d62iuk72	3	1	PLoS	PLoS	NNP
cord-001859-d62iuk72	3	2	Pathog	Pathog	NNP
cord-001859-d62iuk72	3	3	DOI	DOI	NNP
cord-001859-d62iuk72	3	4	:	:	:
cord-001859-d62iuk72	4	1	10.1371	10.1371	CD
cord-001859-d62iuk72	4	2	/	/	SYM
cord-001859-d62iuk72	4	3	journal.ppat.1005274	journal.ppat.1005274	NNP
cord-001859-d62iuk72	4	4	sha	sha	NNP
cord-001859-d62iuk72	4	5	:	:	:
cord-001859-d62iuk72	4	6	717168e782bf72b65add057c1cebe8d1bfdffbda	717168e782bf72b65add057c1cebe8d1bfdffbda	CD
cord-001859-d62iuk72	4	7	doc_id	doc_id	CD
cord-001859-d62iuk72	4	8	:	:	:
cord-001859-d62iuk72	5	1	1859	1859	CD
cord-001859-d62iuk72	5	2	cord_uid	cord_uid	NNS
cord-001859-d62iuk72	5	3	:	:	:
cord-001859-d62iuk72	6	1	d62iuk72	d62iuk72	NNP
cord-001859-d62iuk72	6	2	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	6	3	’s	’s	POS
cord-001859-d62iuk72	6	4	sarcoma	sarcoma	NN
cord-001859-d62iuk72	6	5	-	-	HYPH
cord-001859-d62iuk72	6	6	associated	associate	VBN
cord-001859-d62iuk72	6	7	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	6	8	(	(	-LRB-
cord-001859-d62iuk72	6	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	6	10	)	)	-RRB-
cord-001859-d62iuk72	6	11	is	be	VBZ
cord-001859-d62iuk72	6	12	an	an	DT
cord-001859-d62iuk72	6	13	oncogenic	oncogenic	JJ
cord-001859-d62iuk72	6	14	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	6	15	associated	associate	VBN
cord-001859-d62iuk72	6	16	with	with	IN
cord-001859-d62iuk72	6	17	various	various	JJ
cord-001859-d62iuk72	6	18	AIDS	AIDS	NNP
cord-001859-d62iuk72	6	19	-	-	HYPH
cord-001859-d62iuk72	6	20	related	relate	VBN
cord-001859-d62iuk72	6	21	malignancies	malignancy	NNS
cord-001859-d62iuk72	6	22	.	.	.
cord-001859-d62iuk72	7	1	Like	like	IN
cord-001859-d62iuk72	7	2	other	other	JJ
cord-001859-d62iuk72	7	3	herpesviruses	herpesviruse	NNS
cord-001859-d62iuk72	7	4	,	,	,
cord-001859-d62iuk72	7	5	multiple	multiple	JJ
cord-001859-d62iuk72	7	6	processes	process	NNS
cord-001859-d62iuk72	7	7	required	require	VBN
cord-001859-d62iuk72	7	8	for	for	IN
cord-001859-d62iuk72	7	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	7	10	lytic	lytic	JJ
cord-001859-d62iuk72	7	11	replication	replication	NN
cord-001859-d62iuk72	7	12	,	,	,
cord-001859-d62iuk72	7	13	including	include	VBG
cord-001859-d62iuk72	7	14	viral	viral	JJ
cord-001859-d62iuk72	7	15	transcription	transcription	NN
cord-001859-d62iuk72	7	16	,	,	,
cord-001859-d62iuk72	7	17	viral	viral	JJ
cord-001859-d62iuk72	7	18	DNA	dna	NN
cord-001859-d62iuk72	7	19	synthesis	synthesis	NN
cord-001859-d62iuk72	7	20	and	and	CC
cord-001859-d62iuk72	7	21	capsid	capsid	NN
cord-001859-d62iuk72	7	22	assembly	assembly	NN
cord-001859-d62iuk72	7	23	occur	occur	VBP
cord-001859-d62iuk72	7	24	in	in	IN
cord-001859-d62iuk72	7	25	virus	virus	NN
cord-001859-d62iuk72	7	26	-	-	HYPH
cord-001859-d62iuk72	7	27	induced	induce	VBN
cord-001859-d62iuk72	7	28	intranuclear	intranuclear	NN
cord-001859-d62iuk72	7	29	structures	structure	NNS
cord-001859-d62iuk72	7	30	,	,	,
cord-001859-d62iuk72	7	31	termed	term	VBD
cord-001859-d62iuk72	7	32	replication	replication	NN
cord-001859-d62iuk72	7	33	and	and	CC
cord-001859-d62iuk72	7	34	transcription	transcription	NN
cord-001859-d62iuk72	7	35	compartments	compartment	NNS
cord-001859-d62iuk72	7	36	(	(	-LRB-
cord-001859-d62iuk72	7	37	RTCs	RTCs	NNP
cord-001859-d62iuk72	7	38	)	)	-RRB-
cord-001859-d62iuk72	7	39	.	.	.
cord-001859-d62iuk72	8	1	Here	here	RB
cord-001859-d62iuk72	8	2	we	-PRON-	PRP
cord-001859-d62iuk72	8	3	utilised	utilise	VBD
cord-001859-d62iuk72	8	4	a	a	DT
cord-001859-d62iuk72	8	5	novel	novel	NN
cord-001859-d62iuk72	8	6	methodology	methodology	NN
cord-001859-d62iuk72	8	7	,	,	,
cord-001859-d62iuk72	8	8	combining	combine	VBG
cord-001859-d62iuk72	8	9	subcellular	subcellular	JJ
cord-001859-d62iuk72	8	10	fractionation	fractionation	NN
cord-001859-d62iuk72	8	11	and	and	CC
cord-001859-d62iuk72	8	12	quantitative	quantitative	JJ
cord-001859-d62iuk72	8	13	proteomics	proteomic	NNS
cord-001859-d62iuk72	8	14	,	,	,
cord-001859-d62iuk72	8	15	to	to	TO
cord-001859-d62iuk72	8	16	identify	identify	VB
cord-001859-d62iuk72	8	17	cellular	cellular	JJ
cord-001859-d62iuk72	8	18	proteins	protein	NNS
cord-001859-d62iuk72	8	19	which	which	WDT
cord-001859-d62iuk72	8	20	are	be	VBP
cord-001859-d62iuk72	8	21	recruited	recruit	VBN
cord-001859-d62iuk72	8	22	to	to	IN
cord-001859-d62iuk72	8	23	KSHV	KSHV	NNP
cord-001859-d62iuk72	8	24	-	-	HYPH
cord-001859-d62iuk72	8	25	induced	induce	VBN
cord-001859-d62iuk72	8	26	RTCs	rtc	NNS
cord-001859-d62iuk72	8	27	and	and	CC
cord-001859-d62iuk72	8	28	thus	thus	RB
cord-001859-d62iuk72	8	29	play	play	VB
cord-001859-d62iuk72	8	30	a	a	DT
cord-001859-d62iuk72	8	31	key	key	JJ
cord-001859-d62iuk72	8	32	role	role	NN
cord-001859-d62iuk72	8	33	in	in	IN
cord-001859-d62iuk72	8	34	KSHV	KSHV	NNP
cord-001859-d62iuk72	8	35	lytic	lytic	JJ
cord-001859-d62iuk72	8	36	replication	replication	NN
cord-001859-d62iuk72	8	37	.	.	.
cord-001859-d62iuk72	9	1	We	-PRON-	PRP
cord-001859-d62iuk72	9	2	show	show	VBP
cord-001859-d62iuk72	9	3	that	that	IN
cord-001859-d62iuk72	9	4	several	several	JJ
cord-001859-d62iuk72	9	5	isoforms	isoform	NNS
cord-001859-d62iuk72	9	6	of	of	IN
cord-001859-d62iuk72	9	7	the	the	DT
cord-001859-d62iuk72	9	8	HSP70	HSP70	NNP
cord-001859-d62iuk72	9	9	chaperone	chaperone	NN
cord-001859-d62iuk72	9	10	family	family	NN
cord-001859-d62iuk72	9	11	,	,	,
cord-001859-d62iuk72	9	12	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	9	13	and	and	CC
cord-001859-d62iuk72	9	14	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	9	15	,	,	,
cord-001859-d62iuk72	9	16	are	be	VBP
cord-001859-d62iuk72	9	17	redistributed	redistribute	VBN
cord-001859-d62iuk72	9	18	from	from	IN
cord-001859-d62iuk72	9	19	the	the	DT
cord-001859-d62iuk72	9	20	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	9	21	into	into	IN
cord-001859-d62iuk72	9	22	the	the	DT
cord-001859-d62iuk72	9	23	nucleus	nucleus	NN
cord-001859-d62iuk72	9	24	coinciding	coincide	VBG
cord-001859-d62iuk72	9	25	with	with	IN
cord-001859-d62iuk72	9	26	the	the	DT
cord-001859-d62iuk72	9	27	initial	initial	JJ
cord-001859-d62iuk72	9	28	formation	formation	NN
cord-001859-d62iuk72	9	29	of	of	IN
cord-001859-d62iuk72	9	30	KSHV	KSHV	NNP
cord-001859-d62iuk72	9	31	-	-	HYPH
cord-001859-d62iuk72	9	32	induced	induce	VBN
cord-001859-d62iuk72	9	33	RTCs	rtcs	NN
cord-001859-d62iuk72	9	34	.	.	.
cord-001859-d62iuk72	10	1	We	-PRON-	PRP
cord-001859-d62iuk72	10	2	demonstrate	demonstrate	VBP
cord-001859-d62iuk72	10	3	that	that	IN
cord-001859-d62iuk72	10	4	nuclear	nuclear	JJ
cord-001859-d62iuk72	10	5	chaperone	chaperone	NN
cord-001859-d62iuk72	10	6	foci	foci	NN
cord-001859-d62iuk72	10	7	are	be	VBP
cord-001859-d62iuk72	10	8	dynamic	dynamic	JJ
cord-001859-d62iuk72	10	9	,	,	,
cord-001859-d62iuk72	10	10	initially	initially	RB
cord-001859-d62iuk72	10	11	forming	form	VBG
cord-001859-d62iuk72	10	12	adjacent	adjacent	JJ
cord-001859-d62iuk72	10	13	to	to	IN
cord-001859-d62iuk72	10	14	newly	newly	RB
cord-001859-d62iuk72	10	15	formed	form	VBN
cord-001859-d62iuk72	10	16	KSHV	KSHV	NNP
cord-001859-d62iuk72	10	17	RTCs	rtc	NNS
cord-001859-d62iuk72	10	18	,	,	,
cord-001859-d62iuk72	10	19	however	however	RB
cord-001859-d62iuk72	10	20	during	during	IN
cord-001859-d62iuk72	10	21	later	later	JJ
cord-001859-d62iuk72	10	22	time	time	NN
cord-001859-d62iuk72	10	23	points	point	VBZ
cord-001859-d62iuk72	10	24	the	the	DT
cord-001859-d62iuk72	10	25	chaperones	chaperone	NNS
cord-001859-d62iuk72	10	26	move	move	VBP
cord-001859-d62iuk72	10	27	within	within	IN
cord-001859-d62iuk72	10	28	KSHV	KSHV	NNP
cord-001859-d62iuk72	10	29	RTCs	rtc	NNS
cord-001859-d62iuk72	10	30	and	and	CC
cord-001859-d62iuk72	10	31	completely	completely	RB
cord-001859-d62iuk72	10	32	co	co	VB
cord-001859-d62iuk72	10	33	-	-	VB
cord-001859-d62iuk72	10	34	localise	localise	VB
cord-001859-d62iuk72	10	35	with	with	IN
cord-001859-d62iuk72	10	36	actively	actively	RB
cord-001859-d62iuk72	10	37	replicating	replicate	VBG
cord-001859-d62iuk72	10	38	viral	viral	JJ
cord-001859-d62iuk72	10	39	DNA	dna	NN
cord-001859-d62iuk72	10	40	.	.	.
cord-001859-d62iuk72	11	1	The	the	DT
cord-001859-d62iuk72	11	2	functional	functional	JJ
cord-001859-d62iuk72	11	3	significance	significance	NN
cord-001859-d62iuk72	11	4	of	of	IN
cord-001859-d62iuk72	11	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	11	6	isoforms	isoform	NNS
cord-001859-d62iuk72	11	7	recruitment	recruitment	NN
cord-001859-d62iuk72	11	8	into	into	IN
cord-001859-d62iuk72	11	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	11	10	RTCs	RTCs	NNP
cord-001859-d62iuk72	11	11	was	be	VBD
cord-001859-d62iuk72	11	12	also	also	RB
cord-001859-d62iuk72	11	13	examined	examine	VBN
cord-001859-d62iuk72	11	14	using	use	VBG
cord-001859-d62iuk72	11	15	the	the	DT
cord-001859-d62iuk72	11	16	specific	specific	JJ
cord-001859-d62iuk72	11	17	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	11	18	isoform	isoform	NN
cord-001859-d62iuk72	11	19	small	small	JJ
cord-001859-d62iuk72	11	20	molecule	molecule	NN
cord-001859-d62iuk72	11	21	inhibitor	inhibitor	NN
cord-001859-d62iuk72	11	22	,	,	,
cord-001859-d62iuk72	11	23	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	11	24	.	.	.
cord-001859-d62iuk72	12	1	Intriguingly	intriguingly	RB
cord-001859-d62iuk72	12	2	,	,	,
cord-001859-d62iuk72	12	3	results	result	VBZ
cord-001859-d62iuk72	12	4	highlight	highlight	VBP
cord-001859-d62iuk72	12	5	an	an	DT
cord-001859-d62iuk72	12	6	essential	essential	JJ
cord-001859-d62iuk72	12	7	role	role	NN
cord-001859-d62iuk72	12	8	of	of	IN
cord-001859-d62iuk72	12	9	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	12	10	isoforms	isoform	NNS
cord-001859-d62iuk72	12	11	in	in	IN
cord-001859-d62iuk72	12	12	the	the	DT
cord-001859-d62iuk72	12	13	KSHV	KSHV	NNP
cord-001859-d62iuk72	12	14	replication	replication	NN
cord-001859-d62iuk72	12	15	cycle	cycle	NN
cord-001859-d62iuk72	12	16	independent	independent	JJ
cord-001859-d62iuk72	12	17	of	of	IN
cord-001859-d62iuk72	12	18	protein	protein	NN
cord-001859-d62iuk72	12	19	stability	stability	NN
cord-001859-d62iuk72	12	20	and	and	CC
cord-001859-d62iuk72	12	21	maturation	maturation	NN
cord-001859-d62iuk72	12	22	.	.	.
cord-001859-d62iuk72	13	1	Notably	notably	RB
cord-001859-d62iuk72	13	2	,	,	,
cord-001859-d62iuk72	13	3	inhibition	inhibition	NN
cord-001859-d62iuk72	13	4	of	of	IN
cord-001859-d62iuk72	13	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	13	6	isoforms	isoform	NNS
cord-001859-d62iuk72	13	7	precluded	preclude	VBD
cord-001859-d62iuk72	13	8	KSHV	KSHV	NNP
cord-001859-d62iuk72	13	9	RTC	RTC	NNP
cord-001859-d62iuk72	13	10	formation	formation	NN
cord-001859-d62iuk72	13	11	and	and	CC
cord-001859-d62iuk72	13	12	RNA	RNA	NNP
cord-001859-d62iuk72	13	13	polymerase	polymerase	NN
cord-001859-d62iuk72	13	14	II	II	NNP
cord-001859-d62iuk72	13	15	(	(	-LRB-
cord-001859-d62iuk72	13	16	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	13	17	)	)	-RRB-
cord-001859-d62iuk72	13	18	relocalisation	relocalisation	NN
cord-001859-d62iuk72	13	19	to	to	IN
cord-001859-d62iuk72	13	20	the	the	DT
cord-001859-d62iuk72	13	21	viral	viral	JJ
cord-001859-d62iuk72	13	22	genome	genome	NN
cord-001859-d62iuk72	13	23	leading	lead	VBG
cord-001859-d62iuk72	13	24	to	to	IN
cord-001859-d62iuk72	13	25	the	the	DT
cord-001859-d62iuk72	13	26	abolishment	abolishment	NN
cord-001859-d62iuk72	13	27	of	of	IN
cord-001859-d62iuk72	13	28	global	global	JJ
cord-001859-d62iuk72	13	29	KSHV	KSHV	NNP
cord-001859-d62iuk72	13	30	transcription	transcription	NN
cord-001859-d62iuk72	13	31	and	and	CC
cord-001859-d62iuk72	13	32	subsequent	subsequent	JJ
cord-001859-d62iuk72	13	33	viral	viral	JJ
cord-001859-d62iuk72	13	34	protein	protein	NN
cord-001859-d62iuk72	13	35	synthesis	synthesis	NN
cord-001859-d62iuk72	13	36	and	and	CC
cord-001859-d62iuk72	13	37	DNA	dna	NN
cord-001859-d62iuk72	13	38	replication	replication	NN
cord-001859-d62iuk72	13	39	.	.	.
cord-001859-d62iuk72	14	1	These	these	DT
cord-001859-d62iuk72	14	2	new	new	JJ
cord-001859-d62iuk72	14	3	findings	finding	NNS
cord-001859-d62iuk72	14	4	have	have	VBP
cord-001859-d62iuk72	14	5	revealed	reveal	VBN
cord-001859-d62iuk72	14	6	novel	novel	NN
cord-001859-d62iuk72	14	7	mechanisms	mechanism	NNS
cord-001859-d62iuk72	14	8	that	that	WDT
cord-001859-d62iuk72	14	9	regulate	regulate	VBP
cord-001859-d62iuk72	14	10	KSHV	KSHV	NNP
cord-001859-d62iuk72	14	11	lytic	lytic	JJ
cord-001859-d62iuk72	14	12	replication	replication	NN
cord-001859-d62iuk72	14	13	and	and	CC
cord-001859-d62iuk72	14	14	highlight	highlight	VB
cord-001859-d62iuk72	14	15	the	the	DT
cord-001859-d62iuk72	14	16	potential	potential	NN
cord-001859-d62iuk72	14	17	of	of	IN
cord-001859-d62iuk72	14	18	HSP70	HSP70	NNP
cord-001859-d62iuk72	14	19	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	14	20	as	as	IN
cord-001859-d62iuk72	14	21	novel	novel	JJ
cord-001859-d62iuk72	14	22	antiviral	antiviral	JJ
cord-001859-d62iuk72	14	23	agents	agent	NNS
cord-001859-d62iuk72	14	24	.	.	.
cord-001859-d62iuk72	15	1	Molecular	molecular	JJ
cord-001859-d62iuk72	15	2	chaperones	chaperone	NNS
cord-001859-d62iuk72	15	3	represent	represent	VBP
cord-001859-d62iuk72	15	4	a	a	DT
cord-001859-d62iuk72	15	5	large	large	JJ
cord-001859-d62iuk72	15	6	group	group	NN
cord-001859-d62iuk72	15	7	of	of	IN
cord-001859-d62iuk72	15	8	proteins	protein	NNS
cord-001859-d62iuk72	15	9	that	that	WDT
cord-001859-d62iuk72	15	10	are	be	VBP
cord-001859-d62iuk72	15	11	essential	essential	JJ
cord-001859-d62iuk72	15	12	for	for	IN
cord-001859-d62iuk72	15	13	maintaining	maintain	VBG
cord-001859-d62iuk72	15	14	cellular	cellular	JJ
cord-001859-d62iuk72	15	15	homeostasis	homeostasis	NN
cord-001859-d62iuk72	15	16	and	and	CC
cord-001859-d62iuk72	15	17	survival	survival	NN
cord-001859-d62iuk72	15	18	.	.	.
cord-001859-d62iuk72	16	1	As	as	IN
cord-001859-d62iuk72	16	2	such	such	JJ
cord-001859-d62iuk72	16	3	,	,	,
cord-001859-d62iuk72	16	4	the	the	DT
cord-001859-d62iuk72	16	5	roles	role	NNS
cord-001859-d62iuk72	16	6	of	of	IN
cord-001859-d62iuk72	16	7	these	these	DT
cord-001859-d62iuk72	16	8	proteins	protein	NNS
cord-001859-d62iuk72	16	9	are	be	VBP
cord-001859-d62iuk72	16	10	numerous	numerous	JJ
cord-001859-d62iuk72	16	11	;	;	:
cord-001859-d62iuk72	16	12	facilitating	facilitate	VBG
cord-001859-d62iuk72	16	13	correct	correct	JJ
cord-001859-d62iuk72	16	14	protein	protein	NN
cord-001859-d62iuk72	16	15	folding	folding	NN
cord-001859-d62iuk72	16	16	or	or	CC
cord-001859-d62iuk72	16	17	unfolding	unfolding	NN
cord-001859-d62iuk72	16	18	,	,	,
cord-001859-d62iuk72	16	19	assembly	assembly	NN
cord-001859-d62iuk72	16	20	or	or	CC
cord-001859-d62iuk72	16	21	disassembly	disassembly	NN
cord-001859-d62iuk72	16	22	of	of	IN
cord-001859-d62iuk72	16	23	multimeric	multimeric	JJ
cord-001859-d62iuk72	16	24	protein	protein	NN
cord-001859-d62iuk72	16	25	complexes	complex	NNS
cord-001859-d62iuk72	16	26	,	,	,
cord-001859-d62iuk72	16	27	participating	participate	VBG
cord-001859-d62iuk72	16	28	in	in	IN
cord-001859-d62iuk72	16	29	translocation	translocation	NN
cord-001859-d62iuk72	16	30	of	of	IN
cord-001859-d62iuk72	16	31	proteins	protein	NNS
cord-001859-d62iuk72	16	32	and	and	CC
cord-001859-d62iuk72	16	33	vesicles	vesicle	NNS
cord-001859-d62iuk72	16	34	into	into	IN
cord-001859-d62iuk72	16	35	organelles	organelle	NNS
cord-001859-d62iuk72	16	36	,	,	,
cord-001859-d62iuk72	16	37	stabilising	stabilise	VBG
cord-001859-d62iuk72	16	38	a	a	DT
cord-001859-d62iuk72	16	39	wide	wide	JJ
cord-001859-d62iuk72	16	40	range	range	NN
cord-001859-d62iuk72	16	41	of	of	IN
cord-001859-d62iuk72	16	42	signalling	signal	VBG
cord-001859-d62iuk72	16	43	molecules	molecule	NNS
cord-001859-d62iuk72	16	44	and	and	CC
cord-001859-d62iuk72	16	45	preventing	prevent	VBG
cord-001859-d62iuk72	16	46	aggregation	aggregation	NN
cord-001859-d62iuk72	16	47	of	of	IN
cord-001859-d62iuk72	16	48	non	non	JJ
cord-001859-d62iuk72	16	49	-	-	JJ
cord-001859-d62iuk72	16	50	native	native	JJ
cord-001859-d62iuk72	16	51	proteins	protein	NNS
cord-001859-d62iuk72	16	52	(	(	-LRB-
cord-001859-d62iuk72	16	53	reviewed	review	VBN
cord-001859-d62iuk72	16	54	in	in	IN
cord-001859-d62iuk72	16	55	[	[	-LRB-
cord-001859-d62iuk72	16	56	1	1	CD
cord-001859-d62iuk72	16	57	,	,	,
cord-001859-d62iuk72	16	58	2	2	CD
cord-001859-d62iuk72	16	59	]	]	-RRB-
cord-001859-d62iuk72	16	60	)	)	-RRB-
cord-001859-d62iuk72	16	61	.	.	.
cord-001859-d62iuk72	17	1	Heat	heat	NN
cord-001859-d62iuk72	17	2	shock	shock	NN
cord-001859-d62iuk72	17	3	proteins	protein	NNS
cord-001859-d62iuk72	17	4	(	(	-LRB-
cord-001859-d62iuk72	17	5	HSP	HSP	NNP
cord-001859-d62iuk72	17	6	)	)	-RRB-
cord-001859-d62iuk72	17	7	are	be	VBP
cord-001859-d62iuk72	17	8	classified	classify	VBN
cord-001859-d62iuk72	17	9	according	accord	VBG
cord-001859-d62iuk72	17	10	to	to	IN
cord-001859-d62iuk72	17	11	their	-PRON-	PRP$
cord-001859-d62iuk72	17	12	molecular	molecular	JJ
cord-001859-d62iuk72	17	13	weight	weight	NN
cord-001859-d62iuk72	17	14	into	into	IN
cord-001859-d62iuk72	17	15	several	several	JJ
cord-001859-d62iuk72	17	16	families	family	NNS
cord-001859-d62iuk72	17	17	:	:	:
cord-001859-d62iuk72	18	1	HSP40	HSP40	NNP
cord-001859-d62iuk72	18	2	,	,	,
cord-001859-d62iuk72	18	3	HSP60	hsp60	UH
cord-001859-d62iuk72	18	4	,	,	,
cord-001859-d62iuk72	18	5	HSP70	HSP70	NNP
cord-001859-d62iuk72	18	6	,	,	,
cord-001859-d62iuk72	18	7	HSP90	HSP90	NNP
cord-001859-d62iuk72	18	8	,	,	,
cord-001859-d62iuk72	18	9	HSP100	hsp100	UH
cord-001859-d62iuk72	18	10	,	,	,
cord-001859-d62iuk72	18	11	HSP110	HSP110	NNP
cord-001859-d62iuk72	18	12	and	and	CC
cord-001859-d62iuk72	18	13	the	the	DT
cord-001859-d62iuk72	18	14	small	small	JJ
cord-001859-d62iuk72	18	15	HSP	HSP	NNP
cord-001859-d62iuk72	18	16	(	(	-LRB-
cord-001859-d62iuk72	18	17	less	less	JJR
cord-001859-d62iuk72	18	18	than	than	IN
cord-001859-d62iuk72	18	19	34	34	CD
cord-001859-d62iuk72	18	20	kDa	kDa	NNS
cord-001859-d62iuk72	18	21	)	)	-RRB-
cord-001859-d62iuk72	19	1	[	[	-LRB-
cord-001859-d62iuk72	19	2	3	3	CD
cord-001859-d62iuk72	19	3	]	]	-RRB-
cord-001859-d62iuk72	19	4	.	.	.
cord-001859-d62iuk72	20	1	The	the	DT
cord-001859-d62iuk72	20	2	functional	functional	JJ
cord-001859-d62iuk72	20	3	importance	importance	NN
cord-001859-d62iuk72	20	4	of	of	IN
cord-001859-d62iuk72	20	5	the	the	DT
cord-001859-d62iuk72	20	6	HSP70	HSP70	NNP
cord-001859-d62iuk72	20	7	and	and	CC
cord-001859-d62iuk72	20	8	HSP90	HSP90	NNP
cord-001859-d62iuk72	20	9	families	family	NNS
cord-001859-d62iuk72	20	10	of	of	IN
cord-001859-d62iuk72	20	11	molecular	molecular	JJ
cord-001859-d62iuk72	20	12	chaperones	chaperone	NNS
cord-001859-d62iuk72	20	13	is	be	VBZ
cord-001859-d62iuk72	20	14	exemplified	exemplify	VBN
cord-001859-d62iuk72	20	15	by	by	IN
cord-001859-d62iuk72	20	16	their	-PRON-	PRP$
cord-001859-d62iuk72	20	17	emerging	emerge	VBG
cord-001859-d62iuk72	20	18	implications	implication	NNS
cord-001859-d62iuk72	20	19	in	in	IN
cord-001859-d62iuk72	20	20	a	a	DT
cord-001859-d62iuk72	20	21	variety	variety	NN
cord-001859-d62iuk72	20	22	of	of	IN
cord-001859-d62iuk72	20	23	diseases	disease	NNS
cord-001859-d62iuk72	20	24	,	,	,
cord-001859-d62iuk72	20	25	including	include	VBG
cord-001859-d62iuk72	20	26	cancer	cancer	NN
cord-001859-d62iuk72	20	27	[	[	-LRB-
cord-001859-d62iuk72	20	28	4	4	CD
cord-001859-d62iuk72	20	29	,	,	,
cord-001859-d62iuk72	20	30	5	5	CD
cord-001859-d62iuk72	20	31	]	]	-RRB-
cord-001859-d62iuk72	20	32	,	,	,
cord-001859-d62iuk72	20	33	neurodegeneration	neurodegeneration	NN
cord-001859-d62iuk72	20	34	[	[	-LRB-
cord-001859-d62iuk72	20	35	6	6	CD
cord-001859-d62iuk72	20	36	]	]	-RRB-
cord-001859-d62iuk72	20	37	or	or	CC
cord-001859-d62iuk72	20	38	viral	viral	JJ
cord-001859-d62iuk72	20	39	infection	infection	NN
cord-001859-d62iuk72	20	40	[	[	-LRB-
cord-001859-d62iuk72	20	41	7	7	CD
cord-001859-d62iuk72	20	42	,	,	,
cord-001859-d62iuk72	20	43	8	8	CD
cord-001859-d62iuk72	20	44	]	]	-RRB-
cord-001859-d62iuk72	20	45	.	.	.
cord-001859-d62iuk72	21	1	As	as	IN
cord-001859-d62iuk72	21	2	such	such	JJ
cord-001859-d62iuk72	21	3	they	-PRON-	PRP
cord-001859-d62iuk72	21	4	have	have	VBP
cord-001859-d62iuk72	21	5	gained	gain	VBN
cord-001859-d62iuk72	21	6	significant	significant	JJ
cord-001859-d62iuk72	21	7	interest	interest	NN
cord-001859-d62iuk72	21	8	recently	recently	RB
cord-001859-d62iuk72	21	9	as	as	IN
cord-001859-d62iuk72	21	10	potential	potential	JJ
cord-001859-d62iuk72	21	11	drug	drug	NN
cord-001859-d62iuk72	21	12	targets	target	NNS
cord-001859-d62iuk72	21	13	.	.	.
cord-001859-d62iuk72	22	1	Eukaryotes	eukaryote	NNS
cord-001859-d62iuk72	22	2	have	have	VBP
cord-001859-d62iuk72	22	3	multiple	multiple	JJ
cord-001859-d62iuk72	22	4	genes	gene	NNS
cord-001859-d62iuk72	22	5	encoding	encode	VBG
cord-001859-d62iuk72	22	6	for	for	IN
cord-001859-d62iuk72	22	7	chaperones	chaperone	NNS
cord-001859-d62iuk72	22	8	of	of	IN
cord-001859-d62iuk72	22	9	the	the	DT
cord-001859-d62iuk72	22	10	HSP70	HSP70	NNP
cord-001859-d62iuk72	22	11	family	family	NN
cord-001859-d62iuk72	22	12	,	,	,
cord-001859-d62iuk72	22	13	which	which	WDT
cord-001859-d62iuk72	22	14	are	be	VBP
cord-001859-d62iuk72	22	15	amongst	amongst	IN
cord-001859-d62iuk72	22	16	the	the	DT
cord-001859-d62iuk72	22	17	most	most	RBS
cord-001859-d62iuk72	22	18	conserved	conserved	JJ
cord-001859-d62iuk72	22	19	proteins	protein	NNS
cord-001859-d62iuk72	22	20	in	in	IN
cord-001859-d62iuk72	22	21	evolution	evolution	NN
cord-001859-d62iuk72	22	22	[	[	-LRB-
cord-001859-d62iuk72	22	23	9	9	CD
cord-001859-d62iuk72	22	24	]	]	-RRB-
cord-001859-d62iuk72	22	25	[	[	-LRB-
cord-001859-d62iuk72	22	26	10	10	CD
cord-001859-d62iuk72	22	27	]	]	-RRB-
cord-001859-d62iuk72	22	28	[	[	-LRB-
cord-001859-d62iuk72	22	29	11	11	CD
cord-001859-d62iuk72	22	30	]	]	-RRB-
cord-001859-d62iuk72	22	31	.	.	.
cord-001859-d62iuk72	23	1	The	the	DT
cord-001859-d62iuk72	23	2	major	major	JJ
cord-001859-d62iuk72	23	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	23	4	isoforms	isoform	NNS
cord-001859-d62iuk72	23	5	are	be	VBP
cord-001859-d62iuk72	23	6	the	the	DT
cord-001859-d62iuk72	23	7	constitutively	constitutively	RB
cord-001859-d62iuk72	23	8	expressed	express	VBN
cord-001859-d62iuk72	23	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	23	10	,	,	,
cord-001859-d62iuk72	23	11	the	the	DT
cord-001859-d62iuk72	23	12	stress	stress	NN
cord-001859-d62iuk72	23	13	-	-	HYPH
cord-001859-d62iuk72	23	14	inducible	inducible	JJ
cord-001859-d62iuk72	23	15	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	23	16	(	(	-LRB-
cord-001859-d62iuk72	23	17	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	23	18	)	)	-RRB-
cord-001859-d62iuk72	23	19	,	,	,
cord-001859-d62iuk72	23	20	the	the	DT
cord-001859-d62iuk72	23	21	endoplasmic	endoplasmic	NN
cord-001859-d62iuk72	23	22	reticulum	reticulum	NN
cord-001859-d62iuk72	23	23	resident	resident	NN
cord-001859-d62iuk72	23	24	(	(	-LRB-
cord-001859-d62iuk72	23	25	Grp78	Grp78	NNP
cord-001859-d62iuk72	23	26	)	)	-RRB-
cord-001859-d62iuk72	23	27	and	and	CC
cord-001859-d62iuk72	23	28	the	the	DT
cord-001859-d62iuk72	23	29	mitochondrial	mitochondrial	JJ
cord-001859-d62iuk72	23	30	form	form	NN
cord-001859-d62iuk72	23	31	(	(	-LRB-
cord-001859-d62iuk72	23	32	Grp75	Grp75	NNP
cord-001859-d62iuk72	23	33	)	)	-RRB-
cord-001859-d62iuk72	23	34	.	.	.
cord-001859-d62iuk72	24	1	All	all	DT
cord-001859-d62iuk72	24	2	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	24	3	isoforms	isoform	NNS
cord-001859-d62iuk72	24	4	have	have	VBP
cord-001859-d62iuk72	24	5	an	an	DT
cord-001859-d62iuk72	24	6	N	n	CD
cord-001859-d62iuk72	24	7	-	-	HYPH
cord-001859-d62iuk72	24	8	terminal	terminal	NN
cord-001859-d62iuk72	24	9	domain	domain	NN
cord-001859-d62iuk72	24	10	which	which	WDT
cord-001859-d62iuk72	24	11	harbours	harbour	VBZ
cord-001859-d62iuk72	24	12	a	a	DT
cord-001859-d62iuk72	24	13	highly	highly	RB
cord-001859-d62iuk72	24	14	conserved	conserved	JJ
cord-001859-d62iuk72	24	15	ATPase	ATPase	NNP
cord-001859-d62iuk72	24	16	and	and	CC
cord-001859-d62iuk72	24	17	a	a	DT
cord-001859-d62iuk72	24	18	C	c	NN
cord-001859-d62iuk72	24	19	-	-	HYPH
cord-001859-d62iuk72	24	20	terminal	terminal	NN
cord-001859-d62iuk72	24	21	substrate	substrate	NN
cord-001859-d62iuk72	24	22	binding	bind	VBG
cord-001859-d62iuk72	24	23	domain	domain	NN
cord-001859-d62iuk72	24	24	[	[	-LRB-
cord-001859-d62iuk72	24	25	1	1	CD
cord-001859-d62iuk72	24	26	]	]	-RRB-
cord-001859-d62iuk72	24	27	.	.	.
cord-001859-d62iuk72	25	1	Hsp90	hsp90	JJ
cord-001859-d62iuk72	25	2	isoforms	isoform	NNS
cord-001859-d62iuk72	25	3	which	which	WDT
cord-001859-d62iuk72	25	4	comprise	comprise	VBP
cord-001859-d62iuk72	25	5	the	the	DT
cord-001859-d62iuk72	25	6	inducible	inducible	JJ
cord-001859-d62iuk72	25	7	and	and	CC
cord-001859-d62iuk72	25	8	constitutively	constitutively	RB
cord-001859-d62iuk72	25	9	-	-	HYPH
cord-001859-d62iuk72	25	10	expressed	express	VBN
cord-001859-d62iuk72	25	11	isoforms	isoform	NNS
cord-001859-d62iuk72	25	12	(	(	-LRB-
cord-001859-d62iuk72	25	13	Hsp90α	hsp90α	VB
cord-001859-d62iuk72	25	14	and	and	CC
cord-001859-d62iuk72	25	15	Hsp90β	Hsp90β	NNP
cord-001859-d62iuk72	25	16	respectively	respectively	RB
cord-001859-d62iuk72	25	17	)	)	-RRB-
cord-001859-d62iuk72	25	18	,	,	,
cord-001859-d62iuk72	25	19	the	the	DT
cord-001859-d62iuk72	25	20	ER	ER	NNP
cord-001859-d62iuk72	25	21	resident	resident	NN
cord-001859-d62iuk72	25	22	(	(	-LRB-
cord-001859-d62iuk72	25	23	Grp74	Grp74	NNP
cord-001859-d62iuk72	25	24	)	)	-RRB-
cord-001859-d62iuk72	25	25	and	and	CC
cord-001859-d62iuk72	25	26	the	the	DT
cord-001859-d62iuk72	25	27	mitochondrial	mitochondrial	JJ
cord-001859-d62iuk72	25	28	form	form	NN
cord-001859-d62iuk72	25	29	(	(	-LRB-
cord-001859-d62iuk72	25	30	TRAP1	TRAP1	NNP
cord-001859-d62iuk72	25	31	)	)	-RRB-
cord-001859-d62iuk72	25	32	,	,	,
cord-001859-d62iuk72	25	33	also	also	RB
cord-001859-d62iuk72	25	34	possess	possess	VBP
cord-001859-d62iuk72	25	35	a	a	DT
cord-001859-d62iuk72	25	36	N	n	CD
cord-001859-d62iuk72	25	37	-	-	HYPH
cord-001859-d62iuk72	25	38	terminal	terminal	NN
cord-001859-d62iuk72	25	39	ATP	ATP	NNP
cord-001859-d62iuk72	25	40	binding	binding	NN
cord-001859-d62iuk72	25	41	domain	domain	NN
cord-001859-d62iuk72	25	42	,	,	,
cord-001859-d62iuk72	25	43	although	although	IN
cord-001859-d62iuk72	25	44	this	this	DT
cord-001859-d62iuk72	25	45	has	have	VBZ
cord-001859-d62iuk72	25	46	no	no	DT
cord-001859-d62iuk72	25	47	similarity	similarity	NN
cord-001859-d62iuk72	25	48	to	to	IN
cord-001859-d62iuk72	25	49	the	the	DT
cord-001859-d62iuk72	25	50	ATP	ATP	NNP
cord-001859-d62iuk72	25	51	-	-	HYPH
cord-001859-d62iuk72	25	52	binding	bind	VBG
cord-001859-d62iuk72	25	53	domain	domain	NN
cord-001859-d62iuk72	25	54	found	find	VBN
cord-001859-d62iuk72	25	55	in	in	IN
cord-001859-d62iuk72	25	56	the	the	DT
cord-001859-d62iuk72	25	57	chaperones	chaperone	NNS
cord-001859-d62iuk72	25	58	of	of	IN
cord-001859-d62iuk72	25	59	the	the	DT
cord-001859-d62iuk72	25	60	HSP70	HSP70	NNP
cord-001859-d62iuk72	25	61	family	family	NN
cord-001859-d62iuk72	25	62	[	[	-LRB-
cord-001859-d62iuk72	25	63	5	5	CD
cord-001859-d62iuk72	25	64	]	]	-RRB-
cord-001859-d62iuk72	25	65	.	.	.
cord-001859-d62iuk72	26	1	The	the	DT
cord-001859-d62iuk72	26	2	presence	presence	NN
cord-001859-d62iuk72	26	3	of	of	IN
cord-001859-d62iuk72	26	4	ATPase	ATPase	NNP
cord-001859-d62iuk72	26	5	pockets	pocket	NNS
cord-001859-d62iuk72	26	6	in	in	IN
cord-001859-d62iuk72	26	7	both	both	DT
cord-001859-d62iuk72	26	8	families	family	NNS
cord-001859-d62iuk72	26	9	of	of	IN
cord-001859-d62iuk72	26	10	chaperones	chaperone	NNS
cord-001859-d62iuk72	26	11	makes	make	VBZ
cord-001859-d62iuk72	26	12	these	these	DT
cord-001859-d62iuk72	26	13	proteins	protein	NNS
cord-001859-d62iuk72	26	14	desirable	desirable	JJ
cord-001859-d62iuk72	26	15	targets	target	NNS
cord-001859-d62iuk72	26	16	for	for	IN
cord-001859-d62iuk72	26	17	small	small	JJ
cord-001859-d62iuk72	26	18	molecule	molecule	NN
cord-001859-d62iuk72	26	19	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	26	20	[	[	-LRB-
cord-001859-d62iuk72	26	21	12	12	CD
cord-001859-d62iuk72	26	22	,	,	,
cord-001859-d62iuk72	26	23	13	13	CD
cord-001859-d62iuk72	26	24	]	]	-RRB-
cord-001859-d62iuk72	26	25	.	.	.
cord-001859-d62iuk72	27	1	The	the	DT
cord-001859-d62iuk72	27	2	therapeutic	therapeutic	JJ
cord-001859-d62iuk72	27	3	potential	potential	NN
cord-001859-d62iuk72	27	4	of	of	IN
cord-001859-d62iuk72	27	5	these	these	DT
cord-001859-d62iuk72	27	6	compounds	compound	NNS
cord-001859-d62iuk72	27	7	is	be	VBZ
cord-001859-d62iuk72	27	8	especially	especially	RB
cord-001859-d62iuk72	27	9	evident	evident	JJ
cord-001859-d62iuk72	27	10	for	for	IN
cord-001859-d62iuk72	27	11	several	several	JJ
cord-001859-d62iuk72	27	12	HSP90	HSP90	NNP
cord-001859-d62iuk72	27	13	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	27	14	,	,	,
cord-001859-d62iuk72	27	15	having	have	VBG
cord-001859-d62iuk72	27	16	already	already	RB
cord-001859-d62iuk72	27	17	reached	reach	VBN
cord-001859-d62iuk72	27	18	phase	phase	NN
cord-001859-d62iuk72	27	19	II	II	NNP
cord-001859-d62iuk72	27	20	and	and	CC
cord-001859-d62iuk72	27	21	III	iii	CD
cord-001859-d62iuk72	27	22	clinical	clinical	JJ
cord-001859-d62iuk72	27	23	trials	trial	NNS
cord-001859-d62iuk72	27	24	[	[	-LRB-
cord-001859-d62iuk72	27	25	14	14	CD
cord-001859-d62iuk72	27	26	,	,	,
cord-001859-d62iuk72	27	27	15	15	CD
cord-001859-d62iuk72	27	28	]	]	-RRB-
cord-001859-d62iuk72	27	29	.	.	.
cord-001859-d62iuk72	28	1	Targeting	target	VBG
cord-001859-d62iuk72	28	2	of	of	IN
cord-001859-d62iuk72	28	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	28	4	isoforms	isoform	NNS
cord-001859-d62iuk72	28	5	has	have	VBZ
cord-001859-d62iuk72	28	6	been	be	VBN
cord-001859-d62iuk72	28	7	more	more	RBR
cord-001859-d62iuk72	28	8	challenging	challenging	JJ
cord-001859-d62iuk72	28	9	[	[	-LRB-
cord-001859-d62iuk72	28	10	12	12	CD
cord-001859-d62iuk72	28	11	]	]	-RRB-
cord-001859-d62iuk72	28	12	,	,	,
cord-001859-d62iuk72	28	13	but	but	CC
cord-001859-d62iuk72	28	14	recently	recently	RB
cord-001859-d62iuk72	28	15	specific	specific	JJ
cord-001859-d62iuk72	28	16	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	28	17	have	have	VBP
cord-001859-d62iuk72	28	18	also	also	RB
cord-001859-d62iuk72	28	19	undergone	undergo	VBN
cord-001859-d62iuk72	28	20	clinical	clinical	JJ
cord-001859-d62iuk72	28	21	trials	trial	NNS
cord-001859-d62iuk72	28	22	[	[	-LRB-
cord-001859-d62iuk72	28	23	16	16	CD
cord-001859-d62iuk72	28	24	,	,	,
cord-001859-d62iuk72	28	25	17	17	CD
cord-001859-d62iuk72	28	26	]	]	-RRB-
cord-001859-d62iuk72	28	27	.	.	.
cord-001859-d62iuk72	29	1	Importantly	importantly	RB
cord-001859-d62iuk72	29	2	,	,	,
cord-001859-d62iuk72	29	3	the	the	DT
cord-001859-d62iuk72	29	4	development	development	NN
cord-001859-d62iuk72	29	5	of	of	IN
cord-001859-d62iuk72	29	6	highly	highly	RB
cord-001859-d62iuk72	29	7	specific	specific	JJ
cord-001859-d62iuk72	29	8	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	29	9	for	for	IN
cord-001859-d62iuk72	29	10	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	29	11	isoforms	isoform	NNS
cord-001859-d62iuk72	29	12	may	may	MD
cord-001859-d62iuk72	29	13	have	have	VB
cord-001859-d62iuk72	29	14	potential	potential	NN
cord-001859-d62iuk72	29	15	for	for	IN
cord-001859-d62iuk72	29	16	the	the	DT
cord-001859-d62iuk72	29	17	treatment	treatment	NN
cord-001859-d62iuk72	29	18	of	of	IN
cord-001859-d62iuk72	29	19	a	a	DT
cord-001859-d62iuk72	29	20	diverse	diverse	JJ
cord-001859-d62iuk72	29	21	group	group	NN
cord-001859-d62iuk72	29	22	of	of	IN
cord-001859-d62iuk72	29	23	viruses	virus	NNS
cord-001859-d62iuk72	29	24	as	as	IN
cord-001859-d62iuk72	29	25	the	the	DT
cord-001859-d62iuk72	29	26	functional	functional	JJ
cord-001859-d62iuk72	29	27	importance	importance	NN
cord-001859-d62iuk72	29	28	of	of	IN
cord-001859-d62iuk72	29	29	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	29	30	isoforms	isoform	NNS
cord-001859-d62iuk72	29	31	in	in	IN
cord-001859-d62iuk72	29	32	the	the	DT
cord-001859-d62iuk72	29	33	life	life	NN
cord-001859-d62iuk72	29	34	cycle	cycle	NN
cord-001859-d62iuk72	29	35	of	of	IN
cord-001859-d62iuk72	29	36	numerous	numerous	JJ
cord-001859-d62iuk72	29	37	viruses	virus	NNS
cord-001859-d62iuk72	29	38	has	have	VBZ
cord-001859-d62iuk72	29	39	been	be	VBN
cord-001859-d62iuk72	29	40	highlighted	highlight	VBN
cord-001859-d62iuk72	29	41	over	over	IN
cord-001859-d62iuk72	29	42	the	the	DT
cord-001859-d62iuk72	29	43	past	past	JJ
cord-001859-d62iuk72	29	44	few	few	JJ
cord-001859-d62iuk72	29	45	years	year	NNS
cord-001859-d62iuk72	29	46	[	[	-LRB-
cord-001859-d62iuk72	29	47	8	8	CD
cord-001859-d62iuk72	29	48	]	]	-RRB-
cord-001859-d62iuk72	29	49	.	.	.
cord-001859-d62iuk72	30	1	Distinct	distinct	JJ
cord-001859-d62iuk72	30	2	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	30	3	isoforms	isoform	NNS
cord-001859-d62iuk72	30	4	are	be	VBP
cord-001859-d62iuk72	30	5	usurped	usurp	VBN
cord-001859-d62iuk72	30	6	to	to	TO
cord-001859-d62iuk72	30	7	aid	aid	VB
cord-001859-d62iuk72	30	8	in	in	IN
cord-001859-d62iuk72	30	9	many	many	JJ
cord-001859-d62iuk72	30	10	stages	stage	NNS
cord-001859-d62iuk72	30	11	of	of	IN
cord-001859-d62iuk72	30	12	viral	viral	JJ
cord-001859-d62iuk72	30	13	replication	replication	NN
cord-001859-d62iuk72	30	14	as	as	RB
cord-001859-d62iuk72	30	15	varied	varied	JJ
cord-001859-d62iuk72	30	16	as	as	IN
cord-001859-d62iuk72	30	17	viral	viral	JJ
cord-001859-d62iuk72	30	18	entry	entry	NN
cord-001859-d62iuk72	30	19	,	,	,
cord-001859-d62iuk72	30	20	uncoating	uncoating	NN
cord-001859-d62iuk72	30	21	,	,	,
cord-001859-d62iuk72	30	22	transcription	transcription	NN
cord-001859-d62iuk72	30	23	,	,	,
cord-001859-d62iuk72	30	24	envelope	envelope	NN
cord-001859-d62iuk72	30	25	protein	protein	NN
cord-001859-d62iuk72	30	26	maturation	maturation	NN
cord-001859-d62iuk72	30	27	,	,	,
cord-001859-d62iuk72	30	28	morphogenesis	morphogenesis	NN
cord-001859-d62iuk72	30	29	or	or	CC
cord-001859-d62iuk72	30	30	DNA	dna	NN
cord-001859-d62iuk72	30	31	replication	replication	NN
cord-001859-d62iuk72	30	32	[	[	-LRB-
cord-001859-d62iuk72	30	33	8	8	CD
cord-001859-d62iuk72	30	34	]	]	-RRB-
cord-001859-d62iuk72	30	35	.	.	.
cord-001859-d62iuk72	31	1	Therefore	therefore	RB
cord-001859-d62iuk72	31	2	,	,	,
cord-001859-d62iuk72	31	3	the	the	DT
cord-001859-d62iuk72	31	4	importance	importance	NN
cord-001859-d62iuk72	31	5	of	of	IN
cord-001859-d62iuk72	31	6	these	these	DT
cord-001859-d62iuk72	31	7	chaperones	chaperone	NNS
cord-001859-d62iuk72	31	8	in	in	IN
cord-001859-d62iuk72	31	9	the	the	DT
cord-001859-d62iuk72	31	10	life	life	NN
cord-001859-d62iuk72	31	11	cycle	cycle	NN
cord-001859-d62iuk72	31	12	of	of	IN
cord-001859-d62iuk72	31	13	such	such	PDT
cord-001859-d62iuk72	31	14	a	a	DT
cord-001859-d62iuk72	31	15	wide	wide	JJ
cord-001859-d62iuk72	31	16	range	range	NN
cord-001859-d62iuk72	31	17	of	of	IN
cord-001859-d62iuk72	31	18	viruses	virus	NNS
cord-001859-d62iuk72	31	19	suggests	suggest	VBZ
cord-001859-d62iuk72	31	20	the	the	DT
cord-001859-d62iuk72	31	21	potential	potential	NN
cord-001859-d62iuk72	31	22	of	of	IN
cord-001859-d62iuk72	31	23	these	these	DT
cord-001859-d62iuk72	31	24	proteins	protein	NNS
cord-001859-d62iuk72	31	25	as	as	IN
cord-001859-d62iuk72	31	26	targets	target	NNS
cord-001859-d62iuk72	31	27	for	for	IN
cord-001859-d62iuk72	31	28	broad	broad	JJ
cord-001859-d62iuk72	31	29	-	-	HYPH
cord-001859-d62iuk72	31	30	spectrum	spectrum	NN
cord-001859-d62iuk72	31	31	antivirals	antiviral	NNS
cord-001859-d62iuk72	31	32	.	.	.
cord-001859-d62iuk72	32	1	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	32	2	's	's	POS
cord-001859-d62iuk72	32	3	sarcoma	sarcoma	NN
cord-001859-d62iuk72	32	4	-	-	HYPH
cord-001859-d62iuk72	32	5	associated	associate	VBN
cord-001859-d62iuk72	32	6	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	32	7	(	(	-LRB-
cord-001859-d62iuk72	32	8	KSHV	KSHV	NNP
cord-001859-d62iuk72	32	9	)	)	-RRB-
cord-001859-d62iuk72	32	10	is	be	VBZ
cord-001859-d62iuk72	32	11	the	the	DT
cord-001859-d62iuk72	32	12	causative	causative	JJ
cord-001859-d62iuk72	32	13	agent	agent	NN
cord-001859-d62iuk72	32	14	of	of	IN
cord-001859-d62iuk72	32	15	several	several	JJ
cord-001859-d62iuk72	32	16	AIDSassociated	aidsassociate	VBN
cord-001859-d62iuk72	32	17	malignancies	malignancy	NNS
cord-001859-d62iuk72	32	18	,	,	,
cord-001859-d62iuk72	32	19	including	include	VBG
cord-001859-d62iuk72	32	20	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	32	21	's	's	POS
cord-001859-d62iuk72	32	22	sarcoma	sarcoma	NN
cord-001859-d62iuk72	32	23	(	(	-LRB-
cord-001859-d62iuk72	32	24	KS	KS	NNP
cord-001859-d62iuk72	32	25	)	)	-RRB-
cord-001859-d62iuk72	32	26	,	,	,
cord-001859-d62iuk72	32	27	a	a	DT
cord-001859-d62iuk72	32	28	highly	highly	RB
cord-001859-d62iuk72	32	29	vascular	vascular	JJ
cord-001859-d62iuk72	32	30	tumour	tumour	NN
cord-001859-d62iuk72	32	31	of	of	IN
cord-001859-d62iuk72	32	32	NE	NE	NNP
cord-001859-d62iuk72	32	33	can	can	MD
cord-001859-d62iuk72	32	34	not	not	RB
cord-001859-d62iuk72	32	35	be	be	VB
cord-001859-d62iuk72	32	36	purified	purify	VBN
cord-001859-d62iuk72	32	37	completely	completely	RB
cord-001859-d62iuk72	32	38	due	due	JJ
cord-001859-d62iuk72	32	39	to	to	IN
cord-001859-d62iuk72	32	40	its	-PRON-	PRP$
cord-001859-d62iuk72	32	41	multiple	multiple	JJ
cord-001859-d62iuk72	32	42	subcellular	subcellular	JJ
cord-001859-d62iuk72	32	43	connections	connection	NNS
cord-001859-d62iuk72	32	44	.	.	.
cord-001859-d62iuk72	33	1	The	the	DT
cord-001859-d62iuk72	33	2	outer	outer	JJ
cord-001859-d62iuk72	33	3	nuclear	nuclear	JJ
cord-001859-d62iuk72	33	4	membrane	membrane	NN
cord-001859-d62iuk72	33	5	is	be	VBZ
cord-001859-d62iuk72	33	6	continuous	continuous	JJ
cord-001859-d62iuk72	33	7	with	with	IN
cord-001859-d62iuk72	33	8	the	the	DT
cord-001859-d62iuk72	33	9	endoplasmic	endoplasmic	NN
cord-001859-d62iuk72	33	10	reticulum	reticulum	NN
cord-001859-d62iuk72	33	11	and	and	CC
cord-001859-d62iuk72	33	12	interacts	interact	VBZ
cord-001859-d62iuk72	33	13	with	with	IN
cord-001859-d62iuk72	33	14	the	the	DT
cord-001859-d62iuk72	33	15	cytoskeleton	cytoskeleton	NN
cord-001859-d62iuk72	33	16	[	[	-LRB-
cord-001859-d62iuk72	33	17	36	36	CD
cord-001859-d62iuk72	33	18	,	,	,
cord-001859-d62iuk72	33	19	37	37	CD
cord-001859-d62iuk72	33	20	]	]	-RRB-
cord-001859-d62iuk72	33	21	while	while	IN
cord-001859-d62iuk72	33	22	the	the	DT
cord-001859-d62iuk72	33	23	inner	inner	JJ
cord-001859-d62iuk72	33	24	nuclear	nuclear	JJ
cord-001859-d62iuk72	33	25	membrane	membrane	NN
cord-001859-d62iuk72	33	26	binds	bind	VBZ
cord-001859-d62iuk72	33	27	to	to	IN
cord-001859-d62iuk72	33	28	host	host	NN
cord-001859-d62iuk72	33	29	chromatin	chromatin	VB
cord-001859-d62iuk72	33	30	[	[	-LRB-
cord-001859-d62iuk72	33	31	38	38	CD
cord-001859-d62iuk72	33	32	]	]	-RRB-
cord-001859-d62iuk72	34	1	[	[	-LRB-
cord-001859-d62iuk72	34	2	39	39	CD
cord-001859-d62iuk72	34	3	]	]	-RRB-
cord-001859-d62iuk72	34	4	[	[	-LRB-
cord-001859-d62iuk72	34	5	40	40	CD
cord-001859-d62iuk72	34	6	]	]	-RRB-
cord-001859-d62iuk72	34	7	.	.	.
cord-001859-d62iuk72	35	1	Thus	thus	RB
cord-001859-d62iuk72	35	2	,	,	,
cord-001859-d62iuk72	35	3	we	-PRON-	PRP
cord-001859-d62iuk72	35	4	took	take	VBD
cord-001859-d62iuk72	35	5	advantage	advantage	NN
cord-001859-d62iuk72	35	6	of	of	IN
cord-001859-d62iuk72	35	7	its	-PRON-	PRP$
cord-001859-d62iuk72	35	8	incomplete	incomplete	JJ
cord-001859-d62iuk72	35	9	purity	purity	NN
cord-001859-d62iuk72	35	10	so	so	IN
cord-001859-d62iuk72	35	11	that	that	IN
cord-001859-d62iuk72	35	12	we	-PRON-	PRP
cord-001859-d62iuk72	35	13	could	could	MD
cord-001859-d62iuk72	35	14	isolate	isolate	VB
cord-001859-d62iuk72	35	15	not	not	RB
cord-001859-d62iuk72	35	16	only	only	RB
cord-001859-d62iuk72	35	17	the	the	DT
cord-001859-d62iuk72	35	18	NE	NE	NNP
cord-001859-d62iuk72	35	19	and	and	CC
cord-001859-d62iuk72	35	20	embedded	embed	VBN
cord-001859-d62iuk72	35	21	nuclear	nuclear	JJ
cord-001859-d62iuk72	35	22	pore	pore	NN
cord-001859-d62iuk72	35	23	complexes	complex	NNS
cord-001859-d62iuk72	35	24	,	,	,
cord-001859-d62iuk72	35	25	but	but	CC
cord-001859-d62iuk72	35	26	also	also	RB
cord-001859-d62iuk72	35	27	components	component	NNS
cord-001859-d62iuk72	35	28	found	find	VBN
cord-001859-d62iuk72	35	29	in	in	IN
cord-001859-d62iuk72	35	30	the	the	DT
cord-001859-d62iuk72	35	31	NE	NE	NNP
cord-001859-d62iuk72	35	32	neighbourhood	neighbourhood	NN
cord-001859-d62iuk72	35	33	,	,	,
cord-001859-d62iuk72	35	34	such	such	JJ
cord-001859-d62iuk72	35	35	as	as	IN
cord-001859-d62iuk72	35	36	RTCs	rtc	NNS
cord-001859-d62iuk72	35	37	.	.	.
cord-001859-d62iuk72	36	1	Utilising	utilise	VBG
cord-001859-d62iuk72	36	2	this	this	DT
cord-001859-d62iuk72	36	3	novel	novel	JJ
cord-001859-d62iuk72	36	4	approach	approach	NN
cord-001859-d62iuk72	36	5	we	-PRON-	PRP
cord-001859-d62iuk72	36	6	demonstrate	demonstrate	VBP
cord-001859-d62iuk72	36	7	that	that	IN
cord-001859-d62iuk72	36	8	cellular	cellular	JJ
cord-001859-d62iuk72	36	9	chaperones	chaperone	NNS
cord-001859-d62iuk72	36	10	from	from	IN
cord-001859-d62iuk72	36	11	the	the	DT
cord-001859-d62iuk72	36	12	HSP70	HSP70	NNP
cord-001859-d62iuk72	36	13	family	family	NN
cord-001859-d62iuk72	36	14	(	(	-LRB-
cord-001859-d62iuk72	36	15	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	36	16	and	and	CC
cord-001859-d62iuk72	36	17	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	36	18	)	)	-RRB-
cord-001859-d62iuk72	36	19	are	be	VBP
cord-001859-d62iuk72	36	20	significantly	significantly	RB
cord-001859-d62iuk72	36	21	increased	increase	VBN
cord-001859-d62iuk72	36	22	in	in	IN
cord-001859-d62iuk72	36	23	the	the	DT
cord-001859-d62iuk72	36	24	NE	NE	NNP
cord-001859-d62iuk72	36	25	-	-	HYPH
cord-001859-d62iuk72	36	26	associated	associate	VBN
cord-001859-d62iuk72	36	27	RTCs	rtc	NNS
cord-001859-d62iuk72	36	28	of	of	IN
cord-001859-d62iuk72	36	29	reactivated	reactivate	VBN
cord-001859-d62iuk72	36	30	cells	cell	NNS
cord-001859-d62iuk72	36	31	.	.	.
cord-001859-d62iuk72	37	1	Functional	functional	JJ
cord-001859-d62iuk72	37	2	dissection	dissection	NN
cord-001859-d62iuk72	37	3	further	further	RB
cord-001859-d62iuk72	37	4	demonstrates	demonstrate	VBZ
cord-001859-d62iuk72	37	5	that	that	IN
cord-001859-d62iuk72	37	6	these	these	DT
cord-001859-d62iuk72	37	7	chaperones	chaperone	NNS
cord-001859-d62iuk72	37	8	were	be	VBD
cord-001859-d62iuk72	37	9	specifically	specifically	RB
cord-001859-d62iuk72	37	10	recruited	recruit	VBN
cord-001859-d62iuk72	37	11	to	to	IN
cord-001859-d62iuk72	37	12	the	the	DT
cord-001859-d62iuk72	37	13	periphery	periphery	NN
cord-001859-d62iuk72	37	14	of	of	IN
cord-001859-d62iuk72	37	15	incipient	incipient	JJ
cord-001859-d62iuk72	37	16	RTCs	rtc	NNS
cord-001859-d62iuk72	37	17	coinciding	coincide	VBG
cord-001859-d62iuk72	37	18	in	in	IN
cord-001859-d62iuk72	37	19	time	time	NN
cord-001859-d62iuk72	37	20	with	with	IN
cord-001859-d62iuk72	37	21	their	-PRON-	PRP$
cord-001859-d62iuk72	37	22	formation	formation	NN
cord-001859-d62iuk72	37	23	.	.	.
cord-001859-d62iuk72	38	1	When	when	WRB
cord-001859-d62iuk72	38	2	actively	actively	RB
cord-001859-d62iuk72	38	3	replicated	replicate	VBD
cord-001859-d62iuk72	38	4	viral	viral	JJ
cord-001859-d62iuk72	38	5	DNA	dna	NN
cord-001859-d62iuk72	38	6	was	be	VBD
cord-001859-d62iuk72	38	7	synthesised	synthesise	VBN
cord-001859-d62iuk72	38	8	the	the	DT
cord-001859-d62iuk72	38	9	chaperones	chaperone	NNS
cord-001859-d62iuk72	38	10	were	be	VBD
cord-001859-d62iuk72	38	11	recruited	recruit	VBN
cord-001859-d62iuk72	38	12	within	within	IN
cord-001859-d62iuk72	38	13	RTCs	rtc	NNS
cord-001859-d62iuk72	38	14	.	.	.
cord-001859-d62iuk72	39	1	Strikingly	strikingly	RB
cord-001859-d62iuk72	39	2	,	,	,
cord-001859-d62iuk72	39	3	inhibition	inhibition	NN
cord-001859-d62iuk72	39	4	of	of	IN
cord-001859-d62iuk72	39	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	39	6	isoforms	isoform	NNS
cord-001859-d62iuk72	39	7	precluded	preclude	VBD
cord-001859-d62iuk72	39	8	RTC	RTC	NNP
cord-001859-d62iuk72	39	9	formation	formation	NN
cord-001859-d62iuk72	39	10	,	,	,
cord-001859-d62iuk72	39	11	curtailed	curtail	VBD
cord-001859-d62iuk72	39	12	chaperone	chaperone	NN
cord-001859-d62iuk72	39	13	redistribution	redistribution	NN
cord-001859-d62iuk72	39	14	within	within	IN
cord-001859-d62iuk72	39	15	RTCs	rtc	NNS
cord-001859-d62iuk72	39	16	and	and	CC
cord-001859-d62iuk72	39	17	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	39	18	recruitment	recruitment	NN
cord-001859-d62iuk72	39	19	to	to	IN
cord-001859-d62iuk72	39	20	viral	viral	JJ
cord-001859-d62iuk72	39	21	promoters	promoter	NNS
cord-001859-d62iuk72	39	22	.	.	.
cord-001859-d62iuk72	40	1	Importantly	importantly	RB
cord-001859-d62iuk72	40	2	,	,	,
cord-001859-d62iuk72	40	3	abrogation	abrogation	NN
cord-001859-d62iuk72	40	4	of	of	IN
cord-001859-d62iuk72	40	5	lytic	lytic	JJ
cord-001859-d62iuk72	40	6	replication	replication	NN
cord-001859-d62iuk72	40	7	occurred	occur	VBD
cord-001859-d62iuk72	40	8	without	without	IN
cord-001859-d62iuk72	40	9	affecting	affect	VBG
cord-001859-d62iuk72	40	10	cell	cell	NN
cord-001859-d62iuk72	40	11	viability	viability	NN
cord-001859-d62iuk72	40	12	,	,	,
cord-001859-d62iuk72	40	13	suggesting	suggest	VBG
cord-001859-d62iuk72	40	14	that	that	IN
cord-001859-d62iuk72	40	15	the	the	DT
cord-001859-d62iuk72	40	16	cellular	cellular	JJ
cord-001859-d62iuk72	40	17	housekeeping	housekeeping	NN
cord-001859-d62iuk72	40	18	functions	function	NNS
cord-001859-d62iuk72	40	19	carried	carry	VBN
cord-001859-d62iuk72	40	20	out	out	RP
cord-001859-d62iuk72	40	21	by	by	IN
cord-001859-d62iuk72	40	22	these	these	DT
cord-001859-d62iuk72	40	23	chaperones	chaperone	NNS
cord-001859-d62iuk72	40	24	were	be	VBD
cord-001859-d62iuk72	40	25	not	not	RB
cord-001859-d62iuk72	40	26	compromised	compromise	VBN
cord-001859-d62iuk72	40	27	.	.	.
cord-001859-d62iuk72	41	1	As	as	IN
cord-001859-d62iuk72	41	2	such	such	JJ
cord-001859-d62iuk72	41	3	,	,	,
cord-001859-d62iuk72	41	4	HSP70	HSP70	NNP
cord-001859-d62iuk72	41	5	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	41	6	may	may	MD
cord-001859-d62iuk72	41	7	provide	provide	VB
cord-001859-d62iuk72	41	8	a	a	DT
cord-001859-d62iuk72	41	9	novel	novel	JJ
cord-001859-d62iuk72	41	10	therapeutic	therapeutic	JJ
cord-001859-d62iuk72	41	11	approach	approach	NN
cord-001859-d62iuk72	41	12	for	for	IN
cord-001859-d62iuk72	41	13	the	the	DT
cord-001859-d62iuk72	41	14	treatment	treatment	NN
cord-001859-d62iuk72	41	15	of	of	IN
cord-001859-d62iuk72	41	16	KSHV	KSHV	NNP
cord-001859-d62iuk72	41	17	-	-	HYPH
cord-001859-d62iuk72	41	18	associated	associate	VBN
cord-001859-d62iuk72	41	19	malignancies	malignancy	NNS
cord-001859-d62iuk72	41	20	,	,	,
cord-001859-d62iuk72	41	21	in	in	IN
cord-001859-d62iuk72	41	22	particular	particular	JJ
cord-001859-d62iuk72	41	23	it	-PRON-	PRP
cord-001859-d62iuk72	41	24	would	would	MD
cord-001859-d62iuk72	41	25	be	be	VB
cord-001859-d62iuk72	41	26	interesting	interesting	JJ
cord-001859-d62iuk72	41	27	to	to	TO
cord-001859-d62iuk72	41	28	determine	determine	VB
cord-001859-d62iuk72	41	29	the	the	DT
cord-001859-d62iuk72	41	30	efficacy	efficacy	NN
cord-001859-d62iuk72	41	31	of	of	IN
cord-001859-d62iuk72	41	32	combining	combine	VBG
cord-001859-d62iuk72	41	33	the	the	DT
cord-001859-d62iuk72	41	34	potential	potential	NN
cord-001859-d62iuk72	41	35	of	of	IN
cord-001859-d62iuk72	41	36	inhibiting	inhibit	VBG
cord-001859-d62iuk72	41	37	lytic	lytic	JJ
cord-001859-d62iuk72	41	38	replication	replication	NN
cord-001859-d62iuk72	41	39	using	use	VBG
cord-001859-d62iuk72	41	40	HSP70	HSP70	NNP
cord-001859-d62iuk72	41	41	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	41	42	with	with	IN
cord-001859-d62iuk72	41	43	the	the	DT
cord-001859-d62iuk72	41	44	previous	previous	JJ
cord-001859-d62iuk72	41	45	reported	report	VBN
cord-001859-d62iuk72	41	46	effect	effect	NN
cord-001859-d62iuk72	41	47	of	of	IN
cord-001859-d62iuk72	41	48	HSP90	HSP90	NNP
cord-001859-d62iuk72	41	49	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	41	50	to	to	TO
cord-001859-d62iuk72	41	51	eradicate	eradicate	VB
cord-001859-d62iuk72	41	52	latent	latent	JJ
cord-001859-d62iuk72	41	53	KSHV	KSHV	NNP
cord-001859-d62iuk72	41	54	reservoirs	reservoir	NNS
cord-001859-d62iuk72	41	55	[	[	-LRB-
cord-001859-d62iuk72	41	56	41	41	CD
cord-001859-d62iuk72	41	57	]	]	-RRB-
cord-001859-d62iuk72	41	58	.	.	.
cord-001859-d62iuk72	42	1	The	the	DT
cord-001859-d62iuk72	42	2	cellular	cellular	JJ
cord-001859-d62iuk72	42	3	chaperones	chaperone	NNS
cord-001859-d62iuk72	43	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	43	2	,	,	,
cord-001859-d62iuk72	44	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	44	2	and	and	CC
cord-001859-d62iuk72	44	3	Grp78	Grp78	NNP
cord-001859-d62iuk72	44	4	were	be	VBD
cord-001859-d62iuk72	44	5	enhanced	enhance	VBN
cord-001859-d62iuk72	44	6	in	in	IN
cord-001859-d62iuk72	44	7	the	the	DT
cord-001859-d62iuk72	44	8	NE	NE	NNP
cord-001859-d62iuk72	44	9	-	-	HYPH
cord-001859-d62iuk72	44	10	associated	associate	VBN
cord-001859-d62iuk72	44	11	RTCs	rtc	NNS
cord-001859-d62iuk72	44	12	of	of	IN
cord-001859-d62iuk72	44	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	44	14	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	44	15	T	t	NN
cord-001859-d62iuk72	44	16	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	44	17	cells	cell	NNS
cord-001859-d62iuk72	44	18	To	to	TO
cord-001859-d62iuk72	44	19	investigate	investigate	VB
cord-001859-d62iuk72	44	20	differential	differential	JJ
cord-001859-d62iuk72	44	21	proteome	proteome	NN
cord-001859-d62iuk72	44	22	changes	change	NNS
cord-001859-d62iuk72	44	23	which	which	WDT
cord-001859-d62iuk72	44	24	occur	occur	VBP
cord-001859-d62iuk72	44	25	during	during	IN
cord-001859-d62iuk72	44	26	KSHV	KSHV	NNP
cord-001859-d62iuk72	44	27	lytic	lytic	JJ
cord-001859-d62iuk72	44	28	replication	replication	NN
cord-001859-d62iuk72	44	29	in	in	IN
cord-001859-d62iuk72	44	30	NE	NE	NNP
cord-001859-d62iuk72	44	31	-	-	HYPH
cord-001859-d62iuk72	44	32	associated	associate	VBN
cord-001859-d62iuk72	44	33	RTCs	rtc	NNS
cord-001859-d62iuk72	44	34	,	,	,
cord-001859-d62iuk72	44	35	we	-PRON-	PRP
cord-001859-d62iuk72	44	36	utilised	utilise	VBD
cord-001859-d62iuk72	44	37	the	the	DT
cord-001859-d62iuk72	44	38	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	44	39	T	T	NNP
cord-001859-d62iuk72	44	40	cell	cell	NN
cord-001859-d62iuk72	44	41	line	line	NN
cord-001859-d62iuk72	44	42	containing	contain	VBG
cord-001859-d62iuk72	44	43	a	a	DT
cord-001859-d62iuk72	44	44	latent	latent	JJ
cord-001859-d62iuk72	44	45	recombinant	recombinant	JJ
cord-001859-d62iuk72	44	46	KSHV	KSHV	NNP
cord-001859-d62iuk72	44	47	virus	virus	NN
cord-001859-d62iuk72	44	48	(	(	-LRB-
cord-001859-d62iuk72	44	49	rKSHV.219	rKSHV.219	NFP
cord-001859-d62iuk72	44	50	)	)	-RRB-
cord-001859-d62iuk72	44	51	[	[	-LRB-
cord-001859-d62iuk72	44	52	42	42	CD
cord-001859-d62iuk72	44	53	]	]	-RRB-
cord-001859-d62iuk72	44	54	.	.	.
cord-001859-d62iuk72	45	1	This	this	DT
cord-001859-d62iuk72	45	2	cell	cell	NN
cord-001859-d62iuk72	45	3	line	line	NN
cord-001859-d62iuk72	45	4	can	can	MD
cord-001859-d62iuk72	45	5	be	be	VB
cord-001859-d62iuk72	45	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	45	7	into	into	IN
cord-001859-d62iuk72	45	8	a	a	DT
cord-001859-d62iuk72	45	9	full	full	JJ
cord-001859-d62iuk72	45	10	lytic	lytic	JJ
cord-001859-d62iuk72	45	11	replication	replication	NN
cord-001859-d62iuk72	45	12	cycle	cycle	NN
cord-001859-d62iuk72	45	13	via	via	IN
cord-001859-d62iuk72	45	14	chemical	chemical	JJ
cord-001859-d62iuk72	45	15	induction	induction	NN
cord-001859-d62iuk72	45	16	.	.	.
cord-001859-d62iuk72	46	1	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	46	2	cells	cell	NNS
cord-001859-d62iuk72	46	3	were	be	VBD
cord-001859-d62iuk72	46	4	grown	grow	VBN
cord-001859-d62iuk72	46	5	in	in	IN
cord-001859-d62iuk72	46	6	isotopically	isotopically	RB
cord-001859-d62iuk72	46	7	labelled	label	VBN
cord-001859-d62iuk72	46	8	media	medium	NNS
cord-001859-d62iuk72	46	9	(	(	-LRB-
cord-001859-d62iuk72	46	10	R6K4	R6K4	NNP
cord-001859-d62iuk72	46	11	)	)	-RRB-
cord-001859-d62iuk72	46	12	,	,	,
cord-001859-d62iuk72	46	13	while	while	IN
cord-001859-d62iuk72	46	14	cells	cell	NNS
cord-001859-d62iuk72	46	15	to	to	TO
cord-001859-d62iuk72	46	16	be	be	VB
cord-001859-d62iuk72	46	17	reactivated	reactivate	VBN
cord-001859-d62iuk72	46	18	were	be	VBD
cord-001859-d62iuk72	46	19	grown	grow	VBN
cord-001859-d62iuk72	46	20	in	in	IN
cord-001859-d62iuk72	46	21	label	label	NN
cord-001859-d62iuk72	46	22	-	-	HYPH
cord-001859-d62iuk72	46	23	free	free	JJ
cord-001859-d62iuk72	46	24	media	medium	NNS
cord-001859-d62iuk72	46	25	(	(	-LRB-
cord-001859-d62iuk72	46	26	R0K0	R0K0	NNP
cord-001859-d62iuk72	46	27	)	)	-RRB-
cord-001859-d62iuk72	46	28	.	.	.
cord-001859-d62iuk72	47	1	After	after	IN
cord-001859-d62iuk72	47	2	isotopic	isotopic	JJ
cord-001859-d62iuk72	47	3	labelling	labelling	NN
cord-001859-d62iuk72	47	4	was	be	VBD
cord-001859-d62iuk72	47	5	complete	complete	JJ
cord-001859-d62iuk72	47	6	,	,	,
cord-001859-d62iuk72	47	7	cells	cell	NNS
cord-001859-d62iuk72	47	8	were	be	VBD
cord-001859-d62iuk72	47	9	reactivated	reactivate	VBN
cord-001859-d62iuk72	47	10	for	for	IN
cord-001859-d62iuk72	47	11	48	48	CD
cord-001859-d62iuk72	47	12	h	h	NN
cord-001859-d62iuk72	47	13	and	and	CC
cord-001859-d62iuk72	47	14	nuclear	nuclear	JJ
cord-001859-d62iuk72	47	15	envelopes	envelope	NNS
cord-001859-d62iuk72	47	16	(	(	-LRB-
cord-001859-d62iuk72	47	17	NEs	ne	NNS
cord-001859-d62iuk72	47	18	)	)	-RRB-
cord-001859-d62iuk72	47	19	were	be	VBD
cord-001859-d62iuk72	47	20	then	then	RB
cord-001859-d62iuk72	47	21	successfully	successfully	RB
cord-001859-d62iuk72	47	22	purified	purify	VBN
cord-001859-d62iuk72	47	23	using	use	VBG
cord-001859-d62iuk72	47	24	a	a	DT
cord-001859-d62iuk72	47	25	recently	recently	RB
cord-001859-d62iuk72	47	26	described	describe	VBN
cord-001859-d62iuk72	47	27	method	method	NN
cord-001859-d62iuk72	47	28	[	[	-LRB-
cord-001859-d62iuk72	47	29	35	35	CD
cord-001859-d62iuk72	47	30	]	]	-RRB-
cord-001859-d62iuk72	47	31	,	,	,
cord-001859-d62iuk72	47	32	with	with	IN
cord-001859-d62iuk72	47	33	minor	minor	JJ
cord-001859-d62iuk72	47	34	modifications	modification	NNS
cord-001859-d62iuk72	47	35	.	.	.
cord-001859-d62iuk72	48	1	Western	western	JJ
cord-001859-d62iuk72	48	2	blot	blot	NN
cord-001859-d62iuk72	48	3	analysis	analysis	NN
cord-001859-d62iuk72	48	4	of	of	IN
cord-001859-d62iuk72	48	5	the	the	DT
cord-001859-d62iuk72	48	6	NE	NE	NNP
cord-001859-d62iuk72	48	7	preparations	preparation	NNS
cord-001859-d62iuk72	48	8	demonstrated	demonstrate	VBD
cord-001859-d62iuk72	48	9	an	an	DT
cord-001859-d62iuk72	48	10	enrichment	enrichment	NN
cord-001859-d62iuk72	48	11	of	of	IN
cord-001859-d62iuk72	48	12	nucleoporins	nucleoporin	NNS
cord-001859-d62iuk72	48	13	(	(	-LRB-
cord-001859-d62iuk72	48	14	Nups	Nups	NNP
cord-001859-d62iuk72	48	15	)	)	-RRB-
cord-001859-d62iuk72	48	16	,	,	,
cord-001859-d62iuk72	48	17	lamins	lamin	NNS
cord-001859-d62iuk72	48	18	and	and	CC
cord-001859-d62iuk72	48	19	histones	histone	NNS
cord-001859-d62iuk72	48	20	and	and	CC
cord-001859-d62iuk72	48	21	a	a	DT
cord-001859-d62iuk72	48	22	loss	loss	NN
cord-001859-d62iuk72	48	23	of	of	IN
cord-001859-d62iuk72	48	24	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	48	25	(	(	-LRB-
cord-001859-d62iuk72	48	26	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	48	27	)	)	-RRB-
cord-001859-d62iuk72	48	28	and	and	CC
cord-001859-d62iuk72	48	29	nucleolar	nucleolar	NN
cord-001859-d62iuk72	48	30	(	(	-LRB-
cord-001859-d62iuk72	48	31	B-23	B-23	NNP
cord-001859-d62iuk72	48	32	,	,	,
cord-001859-d62iuk72	48	33	C-23	C-23	NNP
cord-001859-d62iuk72	48	34	)	)	-RRB-
cord-001859-d62iuk72	48	35	proteins	protein	NNS
cord-001859-d62iuk72	48	36	compared	compare	VBN
cord-001859-d62iuk72	48	37	with	with	IN
cord-001859-d62iuk72	48	38	whole	whole	JJ
cord-001859-d62iuk72	48	39	cell	cell	NN
cord-001859-d62iuk72	48	40	(	(	-LRB-
cord-001859-d62iuk72	48	41	WC	WC	NNP
cord-001859-d62iuk72	48	42	)	)	-RRB-
cord-001859-d62iuk72	48	43	lysates	lysates	NNP
cord-001859-d62iuk72	48	44	(	(	-LRB-
cord-001859-d62iuk72	48	45	Fig	Fig	NNP
cord-001859-d62iuk72	48	46	1	1	CD
cord-001859-d62iuk72	48	47	)	)	-RRB-
cord-001859-d62iuk72	48	48	.	.	.
cord-001859-d62iuk72	49	1	The	the	DT
cord-001859-d62iuk72	49	2	essential	essential	JJ
cord-001859-d62iuk72	49	3	KSHV	KSHV	NNP
cord-001859-d62iuk72	49	4	mRNA	mRNA	NNP
cord-001859-d62iuk72	49	5	processing	processing	NN
cord-001859-d62iuk72	49	6	protein	protein	NN
cord-001859-d62iuk72	49	7	,	,	,
cord-001859-d62iuk72	49	8	ORF57	ORF57	NNP
cord-001859-d62iuk72	49	9	[	[	-LRB-
cord-001859-d62iuk72	49	10	43	43	CD
cord-001859-d62iuk72	49	11	]	]	-RRB-
cord-001859-d62iuk72	49	12	,	,	,
cord-001859-d62iuk72	49	13	and	and	CC
cord-001859-d62iuk72	49	14	viral	viral	JJ
cord-001859-d62iuk72	49	15	RTA	RTA	NNP
cord-001859-d62iuk72	49	16	served	serve	VBD
cord-001859-d62iuk72	49	17	as	as	IN
cord-001859-d62iuk72	49	18	markers	marker	NNS
cord-001859-d62iuk72	49	19	for	for	IN
cord-001859-d62iuk72	49	20	lytic	lytic	JJ
cord-001859-d62iuk72	49	21	viral	viral	JJ
cord-001859-d62iuk72	49	22	replication	replication	NN
cord-001859-d62iuk72	49	23	and	and	CC
cord-001859-d62iuk72	49	24	RTC	RTC	NNP
cord-001859-d62iuk72	49	25	enrichment	enrichment	NN
cord-001859-d62iuk72	49	26	,	,	,
cord-001859-d62iuk72	49	27	as	as	IN
cord-001859-d62iuk72	49	28	both	both	DT
cord-001859-d62iuk72	49	29	of	of	IN
cord-001859-d62iuk72	49	30	these	these	DT
cord-001859-d62iuk72	49	31	proteins	protein	NNS
cord-001859-d62iuk72	49	32	are	be	VBP
cord-001859-d62iuk72	49	33	known	know	VBN
cord-001859-d62iuk72	49	34	to	to	TO
cord-001859-d62iuk72	49	35	be	be	VB
cord-001859-d62iuk72	49	36	recruited	recruit	VBN
cord-001859-d62iuk72	49	37	to	to	IN
cord-001859-d62iuk72	49	38	KSHV	KSHV	NNP
cord-001859-d62iuk72	49	39	RTCs	RTCs	NNP
cord-001859-d62iuk72	49	40	[	[	-LRB-
cord-001859-d62iuk72	49	41	31	31	CD
cord-001859-d62iuk72	49	42	,	,	,
cord-001859-d62iuk72	49	43	44	44	CD
cord-001859-d62iuk72	49	44	]	]	-RRB-
cord-001859-d62iuk72	49	45	.	.	.
cord-001859-d62iuk72	50	1	The	the	DT
cord-001859-d62iuk72	50	2	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	50	3	antibody	antibody	NN
cord-001859-d62iuk72	50	4	(	(	-LRB-
cord-001859-d62iuk72	50	5	Mab414	Mab414	NNP
cord-001859-d62iuk72	50	6	)	)	-RRB-
cord-001859-d62iuk72	50	7	,	,	,
cord-001859-d62iuk72	50	8	which	which	WDT
cord-001859-d62iuk72	50	9	recognises	recognise	VBZ
cord-001859-d62iuk72	50	10	the	the	DT
cord-001859-d62iuk72	50	11	phenylalanine	phenylalanine	NN
cord-001859-d62iuk72	50	12	-	-	HYPH
cord-001859-d62iuk72	50	13	glycine	glycine	NN
cord-001859-d62iuk72	50	14	(	(	-LRB-
cord-001859-d62iuk72	50	15	FG)-repeat	fg)-repeat	CD
cord-001859-d62iuk72	50	16	motif	motif	NN
cord-001859-d62iuk72	50	17	present	present	JJ
cord-001859-d62iuk72	50	18	in	in	IN
cord-001859-d62iuk72	50	19	numerous	numerous	JJ
cord-001859-d62iuk72	50	20	Nups	Nups	NNP
cord-001859-d62iuk72	50	21	,	,	,
cord-001859-d62iuk72	50	22	and	and	CC
cord-001859-d62iuk72	50	23	the	the	DT
cord-001859-d62iuk72	50	24	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	50	25	antibodies	antibody	NNS
cord-001859-d62iuk72	50	26	against	against	IN
cord-001859-d62iuk72	50	27	Nup160	nup160	CD
cord-001859-d62iuk72	50	28	and	and	CC
cord-001859-d62iuk72	50	29	lamin	lamin	NN
cord-001859-d62iuk72	50	30	B1	b1	NN
cord-001859-d62iuk72	50	31	were	be	VBD
cord-001859-d62iuk72	50	32	used	use	VBN
cord-001859-d62iuk72	50	33	to	to	TO
cord-001859-d62iuk72	50	34	assess	assess	VB
cord-001859-d62iuk72	50	35	enrichment	enrichment	NN
cord-001859-d62iuk72	50	36	of	of	IN
cord-001859-d62iuk72	50	37	the	the	DT
cord-001859-d62iuk72	50	38	NE	NE	NNP
cord-001859-d62iuk72	50	39	region	region	NN
cord-001859-d62iuk72	50	40	.	.	.
cord-001859-d62iuk72	51	1	NE	NE	NNP
cord-001859-d62iuk72	51	2	preparations	preparation	NNS
cord-001859-d62iuk72	51	3	showed	show	VBD
cord-001859-d62iuk72	51	4	a	a	DT
cord-001859-d62iuk72	51	5	higher	high	JJR
cord-001859-d62iuk72	51	6	number	number	NN
cord-001859-d62iuk72	51	7	of	of	IN
cord-001859-d62iuk72	51	8	Nups	Nups	NNP
cord-001859-d62iuk72	51	9	(	(	-LRB-
cord-001859-d62iuk72	51	10	closed	closed	JJ
cord-001859-d62iuk72	51	11	arrows	arrow	NNS
cord-001859-d62iuk72	51	12	)	)	-RRB-
cord-001859-d62iuk72	51	13	than	than	IN
cord-001859-d62iuk72	51	14	their	-PRON-	PRP$
cord-001859-d62iuk72	51	15	respective	respective	JJ
cord-001859-d62iuk72	51	16	WC	WC	NNP
cord-001859-d62iuk72	51	17	preparations	preparation	NNS
cord-001859-d62iuk72	51	18	;	;	:
cord-001859-d62iuk72	51	19	although	although	IN
cord-001859-d62iuk72	51	20	some	some	DT
cord-001859-d62iuk72	51	21	Nups	Nups	NNPS
cord-001859-d62iuk72	51	22	were	be	VBD
cord-001859-d62iuk72	51	23	lost	lose	VBN
cord-001859-d62iuk72	51	24	following	follow	VBG
cord-001859-d62iuk72	51	25	0.3	0.3	CD
cord-001859-d62iuk72	51	26	M	m	NN
cord-001859-d62iuk72	51	27	salt	salt	NN
cord-001859-d62iuk72	51	28	wash	wash	NN
cord-001859-d62iuk72	51	29	(	(	-LRB-
cord-001859-d62iuk72	51	30	open	open	JJ
cord-001859-d62iuk72	51	31	arrow	arrow	NN
cord-001859-d62iuk72	51	32	)	)	-RRB-
cord-001859-d62iuk72	51	33	.	.	.
cord-001859-d62iuk72	52	1	Following	follow	VBG
cord-001859-d62iuk72	52	2	LC	LC	NNP
cord-001859-d62iuk72	52	3	-	-	HYPH
cord-001859-d62iuk72	52	4	MS	MS	NNP
cord-001859-d62iuk72	52	5	/	/	SYM
cord-001859-d62iuk72	52	6	MS	MS	NNP
cord-001859-d62iuk72	52	7	analysis	analysis	NN
cord-001859-d62iuk72	52	8	and	and	CC
cord-001859-d62iuk72	52	9	using	use	VBG
cord-001859-d62iuk72	52	10	a	a	DT
cord-001859-d62iuk72	52	11	minimum	minimum	NN
cord-001859-d62iuk72	52	12	of	of	IN
cord-001859-d62iuk72	52	13	three	three	CD
cord-001859-d62iuk72	52	14	unique	unique	JJ
cord-001859-d62iuk72	52	15	peptides	peptide	NNS
cord-001859-d62iuk72	52	16	assigned	assign	VBN
cord-001859-d62iuk72	52	17	to	to	IN
cord-001859-d62iuk72	52	18	a	a	DT
cord-001859-d62iuk72	52	19	single	single	JJ
cord-001859-d62iuk72	52	20	protein	protein	NN
cord-001859-d62iuk72	52	21	,	,	,
cord-001859-d62iuk72	52	22	most	most	JJS
cord-001859-d62iuk72	52	23	proteins	protein	NNS
cord-001859-d62iuk72	52	24	(	(	-LRB-
cord-001859-d62iuk72	52	25	1072	1072	CD
cord-001859-d62iuk72	52	26	)	)	-RRB-
cord-001859-d62iuk72	52	27	remained	remain	VBD
cord-001859-d62iuk72	52	28	unchanged	unchanged	JJ
cord-001859-d62iuk72	52	29	in	in	IN
cord-001859-d62iuk72	52	30	their	-PRON-	PRP$
cord-001859-d62iuk72	52	31	abundance	abundance	NN
cord-001859-d62iuk72	52	32	irrespectively	irrespectively	RB
cord-001859-d62iuk72	52	33	of	of	IN
cord-001859-d62iuk72	52	34	KSHV	KSHV	NNP
cord-001859-d62iuk72	52	35	lytic	lytic	JJ
cord-001859-d62iuk72	52	36	infection	infection	NN
cord-001859-d62iuk72	52	37	and	and	CC
cord-001859-d62iuk72	52	38	only	only	RB
cord-001859-d62iuk72	52	39	five	five	CD
cord-001859-d62iuk72	52	40	proteins	protein	NNS
cord-001859-d62iuk72	52	41	had	have	VBD
cord-001859-d62iuk72	52	42	a	a	DT
cord-001859-d62iuk72	52	43	significant	significant	JJ
cord-001859-d62iuk72	52	44	reduction	reduction	NN
cord-001859-d62iuk72	52	45	(	(	-LRB-
cord-001859-d62iuk72	52	46	ratio	ratio	NN
cord-001859-d62iuk72	52	47	cut	cut	VBN
cord-001859-d62iuk72	52	48	-	-	HYPH
cord-001859-d62iuk72	52	49	off	off	RP
cord-001859-d62iuk72	52	50	<	<	$
cord-001859-d62iuk72	52	51	0.5	0.5	CD
cord-001859-d62iuk72	52	52	)	)	-RRB-
cord-001859-d62iuk72	52	53	in	in	IN
cord-001859-d62iuk72	52	54	NEs	ne	NNS
cord-001859-d62iuk72	52	55	of	of	IN
cord-001859-d62iuk72	52	56	reactivated	reactivate	VBN
cord-001859-d62iuk72	52	57	cells	cell	NNS
cord-001859-d62iuk72	52	58	.	.	.
cord-001859-d62iuk72	53	1	In	in	IN
cord-001859-d62iuk72	53	2	contrast	contrast	NN
cord-001859-d62iuk72	53	3	,	,	,
cord-001859-d62iuk72	53	4	216	216	CD
cord-001859-d62iuk72	53	5	proteins	protein	NNS
cord-001859-d62iuk72	53	6	showed	show	VBD
cord-001859-d62iuk72	53	7	a	a	DT
cord-001859-d62iuk72	53	8	significant	significant	JJ
cord-001859-d62iuk72	53	9	increase	increase	NN
cord-001859-d62iuk72	53	10	(	(	-LRB-
cord-001859-d62iuk72	53	11	ratio	ratio	NN
cord-001859-d62iuk72	53	12	cut	cut	VBN
cord-001859-d62iuk72	53	13	-	-	HYPH
cord-001859-d62iuk72	53	14	off	off	RP
cord-001859-d62iuk72	53	15	>	>	$
cord-001859-d62iuk72	53	16	1.9	1.9	CD
cord-001859-d62iuk72	53	17	)	)	-RRB-
cord-001859-d62iuk72	53	18	during	during	IN
cord-001859-d62iuk72	53	19	lytic	lytic	JJ
cord-001859-d62iuk72	53	20	replication	replication	NN
cord-001859-d62iuk72	53	21	.	.	.
cord-001859-d62iuk72	54	1	Importantly	importantly	RB
cord-001859-d62iuk72	54	2	,	,	,
cord-001859-d62iuk72	54	3	multiple	multiple	JJ
cord-001859-d62iuk72	54	4	cellular	cellular	JJ
cord-001859-d62iuk72	54	5	proteins	protein	NNS
cord-001859-d62iuk72	54	6	that	that	WDT
cord-001859-d62iuk72	54	7	are	be	VBP
cord-001859-d62iuk72	54	8	known	know	VBN
cord-001859-d62iuk72	54	9	or	or	CC
cord-001859-d62iuk72	54	10	expected	expect	VBN
cord-001859-d62iuk72	54	11	to	to	TO
cord-001859-d62iuk72	54	12	localize	localize	VB
cord-001859-d62iuk72	54	13	within	within	IN
cord-001859-d62iuk72	54	14	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	54	15	RTCs	rtc	NNS
cord-001859-d62iuk72	54	16	;	;	,
cord-001859-d62iuk72	54	17	such	such	JJ
cord-001859-d62iuk72	54	18	as	as	IN
cord-001859-d62iuk72	54	19	those	those	DT
cord-001859-d62iuk72	54	20	associated	associate	VBN
cord-001859-d62iuk72	54	21	with	with	IN
cord-001859-d62iuk72	54	22	KSHV	KSHV	NNP
cord-001859-d62iuk72	54	23	ori	ori	NNP
cord-001859-d62iuk72	54	24	-	-	HYPH
cord-001859-d62iuk72	54	25	Lyt	Lyt	NNP
cord-001859-d62iuk72	54	26	,	,	,
cord-001859-d62iuk72	54	27	the	the	DT
cord-001859-d62iuk72	54	28	HCMV	HCMV	NNP
cord-001859-d62iuk72	54	29	transactivator	transactivator	NNP
cord-001859-d62iuk72	54	30	IE2-p86	IE2-p86	NNP
cord-001859-d62iuk72	54	31	protein	protein	NN
cord-001859-d62iuk72	54	32	or	or	CC
cord-001859-d62iuk72	54	33	the	the	DT
cord-001859-d62iuk72	54	34	herpes	herpe	NNS
cord-001859-d62iuk72	54	35	simplex	simplex	NN
cord-001859-d62iuk72	54	36	virus-1	virus-1	NN
cord-001859-d62iuk72	54	37	(	(	-LRB-
cord-001859-d62iuk72	54	38	HSV-1	hsv-1	NN
cord-001859-d62iuk72	54	39	)	)	-RRB-
cord-001859-d62iuk72	55	1	ICP8	icp8	JJ
cord-001859-d62iuk72	55	2	protein	protein	NN
cord-001859-d62iuk72	55	3	were	be	VBD
cord-001859-d62iuk72	55	4	found	find	VBN
cord-001859-d62iuk72	55	5	significantly	significantly	RB
cord-001859-d62iuk72	55	6	increased	increase	VBN
cord-001859-d62iuk72	55	7	in	in	IN
cord-001859-d62iuk72	55	8	the	the	DT
cord-001859-d62iuk72	55	9	NE	NE	NNP
cord-001859-d62iuk72	55	10	regions	region	NNS
cord-001859-d62iuk72	55	11	of	of	IN
cord-001859-d62iuk72	55	12	reactivated	reactivate	VBN
cord-001859-d62iuk72	55	13	cells	cell	NNS
cord-001859-d62iuk72	55	14	using	use	VBG
cord-001859-d62iuk72	55	15	the	the	DT
cord-001859-d62iuk72	55	16	less	less	RBR
cord-001859-d62iuk72	55	17	stringent	stringent	JJ
cord-001859-d62iuk72	55	18	ratio	ratio	NN
cord-001859-d62iuk72	55	19	cut	cut	NN
cord-001859-d62iuk72	55	20	-	-	HYPH
cord-001859-d62iuk72	55	21	off	off	NN
cord-001859-d62iuk72	55	22	of	of	IN
cord-001859-d62iuk72	55	23	1.5	1.5	CD
cord-001859-d62iuk72	55	24	(	(	-LRB-
cord-001859-d62iuk72	55	25	S1	S1	NNP
cord-001859-d62iuk72	55	26	Table	Table	NNP
cord-001859-d62iuk72	55	27	)	)	-RRB-
cord-001859-d62iuk72	55	28	.	.	.
cord-001859-d62iuk72	56	1	Some	some	DT
cord-001859-d62iuk72	56	2	of	of	IN
cord-001859-d62iuk72	56	3	these	these	DT
cord-001859-d62iuk72	56	4	cellular	cellular	JJ
cord-001859-d62iuk72	56	5	proteins	protein	NNS
cord-001859-d62iuk72	56	6	included	include	VBD
cord-001859-d62iuk72	56	7	CSNK2A1	CSNK2A1	NNP
cord-001859-d62iuk72	56	8	[	[	-LRB-
cord-001859-d62iuk72	56	9	45	45	CD
cord-001859-d62iuk72	56	10	]	]	-RRB-
cord-001859-d62iuk72	56	11	,	,	,
cord-001859-d62iuk72	56	12	BLM	BLM	NNP
cord-001859-d62iuk72	56	13	[	[	-LRB-
cord-001859-d62iuk72	56	14	32	32	CD
cord-001859-d62iuk72	56	15	]	]	-RRB-
cord-001859-d62iuk72	56	16	,	,	,
cord-001859-d62iuk72	56	17	topoisomerases	topoisomerase	NNS
cord-001859-d62iuk72	56	18	I	-PRON-	PRP
cord-001859-d62iuk72	56	19	and	and	CC
cord-001859-d62iuk72	56	20	II	II	NNP
cord-001859-d62iuk72	56	21	[	[	-LRB-
cord-001859-d62iuk72	56	22	31	31	CD
cord-001859-d62iuk72	56	23	,	,	,
cord-001859-d62iuk72	56	24	46	46	CD
cord-001859-d62iuk72	56	25	,	,	,
cord-001859-d62iuk72	56	26	47	47	CD
cord-001859-d62iuk72	56	27	]	]	-RRB-
cord-001859-d62iuk72	56	28	and	and	CC
cord-001859-d62iuk72	56	29	DEAD	dead	JJ
cord-001859-d62iuk72	56	30	box	box	NN
cord-001859-d62iuk72	56	31	helicases	helicase	NNS
cord-001859-d62iuk72	57	1	DDX5	DDX5	NNP
cord-001859-d62iuk72	57	2	[	[	-LRB-
cord-001859-d62iuk72	57	3	32	32	CD
cord-001859-d62iuk72	57	4	]	]	-RRB-
cord-001859-d62iuk72	57	5	and	and	CC
cord-001859-d62iuk72	57	6	DDX17	DDX17	NNP
cord-001859-d62iuk72	57	7	[	[	-LRB-
cord-001859-d62iuk72	57	8	45	45	CD
cord-001859-d62iuk72	57	9	]	]	-RRB-
cord-001859-d62iuk72	57	10	.	.	.
cord-001859-d62iuk72	58	1	Thus	thus	RB
cord-001859-d62iuk72	58	2	,	,	,
cord-001859-d62iuk72	58	3	LC	LC	NNP
cord-001859-d62iuk72	58	4	-	-	HYPH
cord-001859-d62iuk72	58	5	MS	MS	NNP
cord-001859-d62iuk72	58	6	/	/	SYM
cord-001859-d62iuk72	58	7	MS	MS	NNP
cord-001859-d62iuk72	58	8	results	result	NNS
cord-001859-d62iuk72	58	9	confirmed	confirm	VBD
cord-001859-d62iuk72	58	10	the	the	DT
cord-001859-d62iuk72	58	11	correct	correct	JJ
cord-001859-d62iuk72	58	12	isolation	isolation	NN
cord-001859-d62iuk72	58	13	of	of	IN
cord-001859-d62iuk72	58	14	the	the	DT
cord-001859-d62iuk72	58	15	NE	NE	NNP
cord-001859-d62iuk72	58	16	region	region	NN
cord-001859-d62iuk72	58	17	and	and	CC
cord-001859-d62iuk72	58	18	accompanying	accompany	VBG
cord-001859-d62iuk72	58	19	RTCs	rtc	NNS
cord-001859-d62iuk72	58	20	.	.	.
cord-001859-d62iuk72	59	1	Importantly	importantly	RB
cord-001859-d62iuk72	59	2	,	,	,
cord-001859-d62iuk72	59	3	many	many	JJ
cord-001859-d62iuk72	59	4	of	of	IN
cord-001859-d62iuk72	59	5	the	the	DT
cord-001859-d62iuk72	59	6	216	216	CD
cord-001859-d62iuk72	59	7	identified	identify	VBN
cord-001859-d62iuk72	59	8	proteins	protein	NNS
cord-001859-d62iuk72	59	9	most	most	RBS
cord-001859-d62iuk72	59	10	likely	likely	RB
cord-001859-d62iuk72	59	11	represent	represent	VBP
cord-001859-d62iuk72	59	12	novel	novel	JJ
cord-001859-d62iuk72	59	13	cellular	cellular	JJ
cord-001859-d62iuk72	59	14	proteins	protein	NNS
cord-001859-d62iuk72	59	15	hijacked	hijack	VBN
cord-001859-d62iuk72	59	16	by	by	IN
cord-001859-d62iuk72	59	17	KSHV	KSHV	NNP
cord-001859-d62iuk72	59	18	,	,	,
cord-001859-d62iuk72	59	19	not	not	RB
cord-001859-d62iuk72	59	20	only	only	RB
cord-001859-d62iuk72	59	21	due	due	IN
cord-001859-d62iuk72	59	22	to	to	IN
cord-001859-d62iuk72	59	23	the	the	DT
cord-001859-d62iuk72	59	24	subcellular	subcellular	JJ
cord-001859-d62iuk72	59	25	fractionation	fractionation	NN
cord-001859-d62iuk72	59	26	carried	carry	VBN
cord-001859-d62iuk72	59	27	out	out	RP
cord-001859-d62iuk72	59	28	but	but	CC
cord-001859-d62iuk72	59	29	also	also	RB
cord-001859-d62iuk72	59	30	to	to	IN
cord-001859-d62iuk72	59	31	the	the	DT
cord-001859-d62iuk72	59	32	uncommon	uncommon	JJ
cord-001859-d62iuk72	59	33	use	use	NN
cord-001859-d62iuk72	59	34	of	of	IN
cord-001859-d62iuk72	59	35	urea	urea	NN
cord-001859-d62iuk72	59	36	for	for	IN
cord-001859-d62iuk72	59	37	protein	protein	NN
cord-001859-d62iuk72	59	38	extraction	extraction	NN
cord-001859-d62iuk72	59	39	before	before	IN
cord-001859-d62iuk72	59	40	LC	LC	NNP
cord-001859-d62iuk72	59	41	-	-	HYPH
cord-001859-d62iuk72	59	42	MS/	MS/	NNP
cord-001859-d62iuk72	59	43	MS	MS	NNP
cord-001859-d62iuk72	59	44	.	.	.
cord-001859-d62iuk72	60	1	All	all	DT
cord-001859-d62iuk72	60	2	proteins	protein	NNS
cord-001859-d62iuk72	60	3	identified	identify	VBN
cord-001859-d62iuk72	60	4	by	by	IN
cord-001859-d62iuk72	60	5	LC	LC	NNP
cord-001859-d62iuk72	60	6	-	-	HYPH
cord-001859-d62iuk72	60	7	MS	MS	NNP
cord-001859-d62iuk72	60	8	/	/	SYM
cord-001859-d62iuk72	60	9	MS	MS	NNP
cord-001859-d62iuk72	60	10	can	can	MD
cord-001859-d62iuk72	60	11	be	be	VB
cord-001859-d62iuk72	60	12	seen	see	VBN
cord-001859-d62iuk72	60	13	on	on	IN
cord-001859-d62iuk72	60	14	S1	S1	NNP
cord-001859-d62iuk72	60	15	Dataset	Dataset	NNP
cord-001859-d62iuk72	60	16	.	.	.
cord-001859-d62iuk72	61	1	Bioinformatical	Bioinformatical	NNP
cord-001859-d62iuk72	61	2	analysis	analysis	NN
cord-001859-d62iuk72	61	3	revealed	reveal	VBD
cord-001859-d62iuk72	61	4	several	several	JJ
cord-001859-d62iuk72	61	5	upregulated	upregulate	VBN
cord-001859-d62iuk72	61	6	pathways	pathway	NNS
cord-001859-d62iuk72	61	7	(	(	-LRB-
cord-001859-d62iuk72	61	8	ratio	ratio	NN
cord-001859-d62iuk72	61	9	cut	cut	VBN
cord-001859-d62iuk72	61	10	-	-	HYPH
cord-001859-d62iuk72	61	11	off	off	RP
cord-001859-d62iuk72	61	12	>	>	$
cord-001859-d62iuk72	61	13	1.9	1.9	CD
cord-001859-d62iuk72	61	14	)	)	-RRB-
cord-001859-d62iuk72	61	15	in	in	IN
cord-001859-d62iuk72	61	16	reactivated	reactivate	VBN
cord-001859-d62iuk72	61	17	cells	cell	NNS
cord-001859-d62iuk72	61	18	(	(	-LRB-
cord-001859-d62iuk72	61	19	S2	S2	NNP
cord-001859-d62iuk72	61	20	Table	Table	NNP
cord-001859-d62iuk72	61	21	)	)	-RRB-
cord-001859-d62iuk72	61	22	.	.	.
cord-001859-d62iuk72	62	1	Of	of	IN
cord-001859-d62iuk72	62	2	particular	particular	JJ
cord-001859-d62iuk72	62	3	interest	interest	NN
cord-001859-d62iuk72	62	4	was	be	VBD
cord-001859-d62iuk72	62	5	an	an	DT
cord-001859-d62iuk72	62	6	upregulated	upregulated	JJ
cord-001859-d62iuk72	62	7	pathway	pathway	NN
cord-001859-d62iuk72	62	8	which	which	WDT
cord-001859-d62iuk72	62	9	related	relate	VBD
cord-001859-d62iuk72	62	10	to	to	IN
cord-001859-d62iuk72	62	11	protein	protein	NN
cord-001859-d62iuk72	62	12	folding	folding	NN
cord-001859-d62iuk72	62	13	.	.	.
cord-001859-d62iuk72	63	1	This	this	DT
cord-001859-d62iuk72	63	2	included	include	VBD
cord-001859-d62iuk72	63	3	several	several	JJ
cord-001859-d62iuk72	63	4	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	63	5	isoforms	isoform	NNS
cord-001859-d62iuk72	63	6	and	and	CC
cord-001859-d62iuk72	63	7	their	-PRON-	PRP$
cord-001859-d62iuk72	63	8	associated	associate	VBN
cord-001859-d62iuk72	63	9	co	co	NNS
cord-001859-d62iuk72	63	10	-	-	NNS
cord-001859-d62iuk72	63	11	chaperones	chaperone	NNS
cord-001859-d62iuk72	63	12	from	from	IN
cord-001859-d62iuk72	63	13	the	the	DT
cord-001859-d62iuk72	63	14	HSP40	HSP40	NNP
cord-001859-d62iuk72	63	15	(	(	-LRB-
cord-001859-d62iuk72	63	16	DNAJ	DNAJ	NNP
cord-001859-d62iuk72	63	17	)	)	-RRB-
cord-001859-d62iuk72	63	18	family	family	NN
cord-001859-d62iuk72	63	19	(	(	-LRB-
cord-001859-d62iuk72	63	20	Table	Table	NNP
cord-001859-d62iuk72	63	21	1	1	CD
cord-001859-d62iuk72	63	22	)	)	-RRB-
cord-001859-d62iuk72	63	23	.	.	.
cord-001859-d62iuk72	64	1	Notably	notably	RB
cord-001859-d62iuk72	64	2	,	,	,
cord-001859-d62iuk72	64	3	the	the	DT
cord-001859-d62iuk72	64	4	constitutively	constitutively	RB
cord-001859-d62iuk72	64	5	expressed	express	VBN
cord-001859-d62iuk72	64	6	chaperone	chaperone	NN
cord-001859-d62iuk72	64	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	64	8	presented	present	VBD
cord-001859-d62iuk72	64	9	a	a	DT
cord-001859-d62iuk72	64	10	4.1-fold	4.1-fold	CD
cord-001859-d62iuk72	64	11	increase	increase	NN
cord-001859-d62iuk72	64	12	with	with	IN
cord-001859-d62iuk72	64	13	41	41	CD
cord-001859-d62iuk72	64	14	unique	unique	JJ
cord-001859-d62iuk72	64	15	peptides	peptide	NNS
cord-001859-d62iuk72	64	16	assigned	assign	VBN
cord-001859-d62iuk72	64	17	.	.	.
cord-001859-d62iuk72	65	1	This	this	DT
cord-001859-d62iuk72	65	2	protein	protein	NN
cord-001859-d62iuk72	65	3	had	have	VBD
cord-001859-d62iuk72	65	4	the	the	DT
cord-001859-d62iuk72	65	5	highest	high	JJS
cord-001859-d62iuk72	65	6	fold	fold	JJ
cord-001859-d62iuk72	65	7	increase	increase	NN
cord-001859-d62iuk72	65	8	associated	associate	VBN
cord-001859-d62iuk72	65	9	with	with	IN
cord-001859-d62iuk72	65	10	the	the	DT
cord-001859-d62iuk72	65	11	most	most	RBS
cord-001859-d62iuk72	65	12	unique	unique	JJ
cord-001859-d62iuk72	65	13	peptide	peptide	JJ
cord-001859-d62iuk72	65	14	number	number	NN
cord-001859-d62iuk72	65	15	of	of	IN
cord-001859-d62iuk72	65	16	all	all	PDT
cord-001859-d62iuk72	65	17	the	the	DT
cord-001859-d62iuk72	65	18	proteins	protein	NNS
cord-001859-d62iuk72	65	19	identified	identify	VBN
cord-001859-d62iuk72	65	20	by	by	IN
cord-001859-d62iuk72	65	21	LC	LC	NNP
cord-001859-d62iuk72	65	22	-	-	HYPH
cord-001859-d62iuk72	65	23	MS	MS	NNP
cord-001859-d62iuk72	65	24	/	/	SYM
cord-001859-d62iuk72	65	25	MS	MS	NNP
cord-001859-d62iuk72	65	26	.	.	.
cord-001859-d62iuk72	66	1	This	this	DT
cord-001859-d62iuk72	66	2	could	could	MD
cord-001859-d62iuk72	66	3	be	be	VB
cord-001859-d62iuk72	66	4	due	due	JJ
cord-001859-d62iuk72	66	5	to	to	IN
cord-001859-d62iuk72	66	6	increased	increase	VBN
cord-001859-d62iuk72	66	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	66	8	expression	expression	NN
cord-001859-d62iuk72	66	9	or	or	CC
cord-001859-d62iuk72	66	10	to	to	IN
cord-001859-d62iuk72	66	11	the	the	DT
cord-001859-d62iuk72	66	12	redistribution	redistribution	NN
cord-001859-d62iuk72	66	13	of	of	IN
cord-001859-d62iuk72	66	14	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	66	15	from	from	IN
cord-001859-d62iuk72	66	16	the	the	DT
cord-001859-d62iuk72	66	17	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	66	18	into	into	IN
cord-001859-d62iuk72	66	19	the	the	DT
cord-001859-d62iuk72	66	20	NE	NE	NNP
cord-001859-d62iuk72	66	21	region	region	NN
cord-001859-d62iuk72	66	22	during	during	IN
cord-001859-d62iuk72	66	23	KSHV	KSHV	NNP
cord-001859-d62iuk72	66	24	lytic	lytic	JJ
cord-001859-d62iuk72	66	25	replication	replication	NN
cord-001859-d62iuk72	66	26	.	.	.
cord-001859-d62iuk72	67	1	Therefore	therefore	RB
cord-001859-d62iuk72	67	2	,	,	,
cord-001859-d62iuk72	67	3	due	due	IN
cord-001859-d62iuk72	67	4	to	to	IN
cord-001859-d62iuk72	67	5	the	the	DT
cord-001859-d62iuk72	67	6	vital	vital	JJ
cord-001859-d62iuk72	67	7	importance	importance	NN
cord-001859-d62iuk72	67	8	of	of	IN
cord-001859-d62iuk72	67	9	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	67	10	isoforms	isoform	NNS
cord-001859-d62iuk72	67	11	in	in	IN
cord-001859-d62iuk72	67	12	the	the	DT
cord-001859-d62iuk72	67	13	replication	replication	NN
cord-001859-d62iuk72	67	14	cycle	cycle	NN
cord-001859-d62iuk72	67	15	of	of	IN
cord-001859-d62iuk72	67	16	a	a	DT
cord-001859-d62iuk72	67	17	wide	wide	JJ
cord-001859-d62iuk72	67	18	range	range	NN
cord-001859-d62iuk72	67	19	of	of	IN
cord-001859-d62iuk72	67	20	viral	viral	JJ
cord-001859-d62iuk72	67	21	families	family	NNS
cord-001859-d62iuk72	67	22	,	,	,
cord-001859-d62iuk72	67	23	we	-PRON-	PRP
cord-001859-d62iuk72	67	24	focussed	focusse	VBD
cord-001859-d62iuk72	67	25	our	-PRON-	PRP$
cord-001859-d62iuk72	67	26	studies	study	NNS
cord-001859-d62iuk72	67	27	herein	herein	RB
cord-001859-d62iuk72	67	28	on	on	IN
cord-001859-d62iuk72	67	29	the	the	DT
cord-001859-d62iuk72	67	30	roles	role	NNS
cord-001859-d62iuk72	67	31	of	of	IN
cord-001859-d62iuk72	67	32	the	the	DT
cord-001859-d62iuk72	67	33	three	three	CD
cord-001859-d62iuk72	67	34	main	main	JJ
cord-001859-d62iuk72	67	35	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	67	36	isoforms	isoform	NNS
cord-001859-d62iuk72	67	37	(	(	-LRB-
cord-001859-d62iuk72	67	38	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	67	39	,	,	,
cord-001859-d62iuk72	67	40	iHsp70	ihsp70	ADD
cord-001859-d62iuk72	68	1	and	and	CC
cord-001859-d62iuk72	68	2	Grp78	Grp78	NNP
cord-001859-d62iuk72	68	3	)	)	-RRB-
cord-001859-d62iuk72	68	4	during	during	IN
cord-001859-d62iuk72	68	5	KSHV	KSHV	NNP
cord-001859-d62iuk72	68	6	lytic	lytic	JJ
cord-001859-d62iuk72	68	7	replication	replication	NN
cord-001859-d62iuk72	68	8	.	.	.
cord-001859-d62iuk72	69	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	69	2	and	and	CC
cord-001859-d62iuk72	69	3	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	69	4	are	be	VBP
cord-001859-d62iuk72	69	5	redistributed	redistribute	VBN
cord-001859-d62iuk72	69	6	from	from	IN
cord-001859-d62iuk72	69	7	the	the	DT
cord-001859-d62iuk72	69	8	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	69	9	to	to	IN
cord-001859-d62iuk72	69	10	both	both	CC
cord-001859-d62iuk72	69	11	the	the	DT
cord-001859-d62iuk72	69	12	periphery	periphery	NN
cord-001859-d62iuk72	69	13	and	and	CC
cord-001859-d62iuk72	69	14	within	within	IN
cord-001859-d62iuk72	69	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	69	16	-	-	HYPH
cord-001859-d62iuk72	69	17	induced	induce	VBN
cord-001859-d62iuk72	69	18	RTCs	rtc	NNS
cord-001859-d62iuk72	69	19	To	to	TO
cord-001859-d62iuk72	69	20	verify	verify	VB
cord-001859-d62iuk72	69	21	the	the	DT
cord-001859-d62iuk72	69	22	enrichment	enrichment	NN
cord-001859-d62iuk72	69	23	of	of	IN
cord-001859-d62iuk72	69	24	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	69	25	in	in	IN
cord-001859-d62iuk72	69	26	the	the	DT
cord-001859-d62iuk72	69	27	NE	NE	NNP
cord-001859-d62iuk72	69	28	-	-	HYPH
cord-001859-d62iuk72	69	29	associated	associate	VBN
cord-001859-d62iuk72	69	30	RTCs	rtc	NNS
cord-001859-d62iuk72	69	31	of	of	IN
cord-001859-d62iuk72	69	32	reactivated	reactivate	VBN
cord-001859-d62iuk72	69	33	cells	cell	NNS
cord-001859-d62iuk72	69	34	detected	detect	VBN
cord-001859-d62iuk72	69	35	by	by	IN
cord-001859-d62iuk72	69	36	our	-PRON-	PRP$
cord-001859-d62iuk72	69	37	quantitative	quantitative	JJ
cord-001859-d62iuk72	69	38	proteomic	proteomic	JJ
cord-001859-d62iuk72	69	39	approach	approach	NN
cord-001859-d62iuk72	69	40	,	,	,
cord-001859-d62iuk72	69	41	indirect	indirect	JJ
cord-001859-d62iuk72	69	42	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	69	43	was	be	VBD
cord-001859-d62iuk72	69	44	used	use	VBN
cord-001859-d62iuk72	69	45	to	to	TO
cord-001859-d62iuk72	69	46	label	label	VB
cord-001859-d62iuk72	69	47	endogenous	endogenous	JJ
cord-001859-d62iuk72	69	48	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	69	49	protein	protein	NN
cord-001859-d62iuk72	69	50	in	in	IN
cord-001859-d62iuk72	69	51	TREx	TREx	NNS
cord-001859-d62iuk72	69	52	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	69	53	cells	cell	NNS
cord-001859-d62iuk72	69	54	,	,	,
cord-001859-d62iuk72	69	55	a	a	DT
cord-001859-d62iuk72	69	56	KSHV	KSHV	NNP
cord-001859-d62iuk72	69	57	latently	latently	RB
cord-001859-d62iuk72	69	58	infected	infect	VBN
cord-001859-d62iuk72	69	59	B	b	NN
cord-001859-d62iuk72	69	60	-	-	HYPH
cord-001859-d62iuk72	69	61	lymphocyte	lymphocyte	NN
cord-001859-d62iuk72	69	62	cell	cell	NN
cord-001859-d62iuk72	69	63	line	line	NN
cord-001859-d62iuk72	69	64	containing	contain	VBG
cord-001859-d62iuk72	69	65	a	a	DT
cord-001859-d62iuk72	69	66	Myc	Myc	NNP
cord-001859-d62iuk72	69	67	-	-	HYPH
cord-001859-d62iuk72	69	68	tagged	tag	VBN
cord-001859-d62iuk72	69	69	version	version	NN
cord-001859-d62iuk72	69	70	of	of	IN
cord-001859-d62iuk72	69	71	viral	viral	JJ
cord-001859-d62iuk72	69	72	RTA	RTA	NNP
cord-001859-d62iuk72	69	73	under	under	IN
cord-001859-d62iuk72	69	74	the	the	DT
cord-001859-d62iuk72	69	75	control	control	NN
cord-001859-d62iuk72	69	76	of	of	IN
cord-001859-d62iuk72	69	77	a	a	DT
cord-001859-d62iuk72	69	78	doxycycline	doxycycline	NN
cord-001859-d62iuk72	69	79	-	-	HYPH
cord-001859-d62iuk72	69	80	inducible	inducible	JJ
cord-001859-d62iuk72	69	81	promoter	promoter	NN
cord-001859-d62iuk72	69	82	[	[	-LRB-
cord-001859-d62iuk72	69	83	48	48	CD
cord-001859-d62iuk72	69	84	]	]	-RRB-
cord-001859-d62iuk72	69	85	.	.	.
cord-001859-d62iuk72	70	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	70	2	protein	protein	NN
cord-001859-d62iuk72	70	3	was	be	VBD
cord-001859-d62iuk72	70	4	equally	equally	RB
cord-001859-d62iuk72	70	5	distributed	distribute	VBN
cord-001859-d62iuk72	70	6	between	between	IN
cord-001859-d62iuk72	70	7	the	the	DT
cord-001859-d62iuk72	70	8	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	70	9	and	and	CC
cord-001859-d62iuk72	70	10	nucleus	nucleus	NN
cord-001859-d62iuk72	70	11	of	of	IN
cord-001859-d62iuk72	70	12	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	70	13	cells	cell	NNS
cord-001859-d62iuk72	70	14	in	in	IN
cord-001859-d62iuk72	70	15	a	a	DT
cord-001859-d62iuk72	70	16	fine	fine	JJ
cord-001859-d62iuk72	70	17	punctuate	punctuate	NN
cord-001859-d62iuk72	70	18	pattern	pattern	NN
cord-001859-d62iuk72	70	19	(	(	-LRB-
cord-001859-d62iuk72	70	20	Fig	Fig	NNP
cord-001859-d62iuk72	70	21	2Ai	2ai	CD
cord-001859-d62iuk72	70	22	)	)	-RRB-
cord-001859-d62iuk72	70	23	.	.	.
cord-001859-d62iuk72	71	1	Similar	similar	JJ
cord-001859-d62iuk72	71	2	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	71	3	localization	localization	NN
cord-001859-d62iuk72	71	4	was	be	VBD
cord-001859-d62iuk72	71	5	seen	see	VBN
cord-001859-d62iuk72	71	6	during	during	IN
cord-001859-d62iuk72	71	7	early	early	JJ
cord-001859-d62iuk72	71	8	lytic	lytic	JJ
cord-001859-d62iuk72	71	9	replication	replication	NN
cord-001859-d62iuk72	71	10	(	(	-LRB-
cord-001859-d62iuk72	71	11	12	12	CD
cord-001859-d62iuk72	71	12	h	h	NN
cord-001859-d62iuk72	71	13	reactivation	reactivation	NN
cord-001859-d62iuk72	71	14	)	)	-RRB-
cord-001859-d62iuk72	71	15	,	,	,
cord-001859-d62iuk72	71	16	when	when	WRB
cord-001859-d62iuk72	71	17	RTA	RTA	NNP
cord-001859-d62iuk72	71	18	protein	protein	NN
cord-001859-d62iuk72	71	19	was	be	VBD
cord-001859-d62iuk72	71	20	diffuse	diffuse	JJ
cord-001859-d62iuk72	71	21	in	in	IN
cord-001859-d62iuk72	71	22	the	the	DT
cord-001859-d62iuk72	71	23	nucleus	nucleus	NN
cord-001859-d62iuk72	71	24	,	,	,
cord-001859-d62iuk72	71	25	Successful	successful	JJ
cord-001859-d62iuk72	71	26	enrichment	enrichment	NN
cord-001859-d62iuk72	71	27	of	of	IN
cord-001859-d62iuk72	71	28	the	the	DT
cord-001859-d62iuk72	71	29	nuclear	nuclear	JJ
cord-001859-d62iuk72	71	30	envelope	envelope	NN
cord-001859-d62iuk72	71	31	region	region	NN
cord-001859-d62iuk72	71	32	and	and	CC
cord-001859-d62iuk72	71	33	associated	associate	VBD
cord-001859-d62iuk72	71	34	KSHV	KSHV	NNP
cord-001859-d62iuk72	71	35	RTCs	rtc	NNS
cord-001859-d62iuk72	71	36	in	in	IN
cord-001859-d62iuk72	71	37	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	71	38	T	t	NN
cord-001859-d62iuk72	71	39	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	71	40	cells	cell	NNS
cord-001859-d62iuk72	71	41	.	.	.
cord-001859-d62iuk72	72	1	Successful	successful	JJ
cord-001859-d62iuk72	72	2	enrichment	enrichment	NN
cord-001859-d62iuk72	72	3	of	of	IN
cord-001859-d62iuk72	72	4	NE	NE	NNP
cord-001859-d62iuk72	72	5	regions	region	NNS
cord-001859-d62iuk72	72	6	in	in	IN
cord-001859-d62iuk72	72	7	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	72	8	(	(	-LRB-
cord-001859-d62iuk72	72	9	-	-	:
cord-001859-d62iuk72	72	10	)	)	-RRB-
cord-001859-d62iuk72	72	11	and	and	CC
cord-001859-d62iuk72	72	12	reactivated	reactivate	VBN
cord-001859-d62iuk72	72	13	for	for	IN
cord-001859-d62iuk72	72	14	48	48	CD
cord-001859-d62iuk72	72	15	h	h	NN
cord-001859-d62iuk72	72	16	(	(	-LRB-
cord-001859-d62iuk72	72	17	+	+	NN
cord-001859-d62iuk72	72	18	)	)	-RRB-
cord-001859-d62iuk72	73	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	74	1	T	T	NNP
cord-001859-d62iuk72	74	2	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	74	3	cells	cell	NNS
cord-001859-d62iuk72	74	4	was	be	VBD
cord-001859-d62iuk72	74	5	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	74	6	by	by	IN
cord-001859-d62iuk72	74	7	Western	western	JJ
cord-001859-d62iuk72	74	8	blotting	blotting	NN
cord-001859-d62iuk72	74	9	.	.	.
cord-001859-d62iuk72	75	1	Equal	equal	JJ
cord-001859-d62iuk72	75	2	amounts	amount	NNS
cord-001859-d62iuk72	75	3	of	of	IN
cord-001859-d62iuk72	75	4	total	total	JJ
cord-001859-d62iuk72	75	5	protein	protein	NN
cord-001859-d62iuk72	75	6	extracted	extract	VBN
cord-001859-d62iuk72	75	7	from	from	IN
cord-001859-d62iuk72	75	8	whole	whole	JJ
cord-001859-d62iuk72	75	9	cell	cell	NN
cord-001859-d62iuk72	75	10	(	(	-LRB-
cord-001859-d62iuk72	75	11	WC	WC	NNP
cord-001859-d62iuk72	75	12	)	)	-RRB-
cord-001859-d62iuk72	75	13	and	and	CC
cord-001859-d62iuk72	75	14	nuclear	nuclear	JJ
cord-001859-d62iuk72	75	15	envelope	envelope	NN
cord-001859-d62iuk72	76	1	(	(	-LRB-
cord-001859-d62iuk72	76	2	NE	NE	NNP
cord-001859-d62iuk72	76	3	)	)	-RRB-
cord-001859-d62iuk72	76	4	fractions	fraction	NNS
cord-001859-d62iuk72	76	5	were	be	VBD
cord-001859-d62iuk72	76	6	used	use	VBN
cord-001859-d62iuk72	76	7	.	.	.
cord-001859-d62iuk72	77	1	The	the	DT
cord-001859-d62iuk72	77	2	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	77	3	antibody	antibody	NN
cord-001859-d62iuk72	77	4	Mab414	Mab414	NNP
cord-001859-d62iuk72	77	5	specifically	specifically	RB
cord-001859-d62iuk72	77	6	recognises	recognise	VBZ
cord-001859-d62iuk72	77	7	the	the	DT
cord-001859-d62iuk72	77	8	phenylalanine	phenylalanine	NN
cord-001859-d62iuk72	77	9	-	-	HYPH
cord-001859-d62iuk72	77	10	glycine	glycine	NN
cord-001859-d62iuk72	77	11	(	(	-LRB-
cord-001859-d62iuk72	77	12	FG)-repeat	fg)-repeat	CD
cord-001859-d62iuk72	77	13	motif	motif	NN
cord-001859-d62iuk72	77	14	present	present	JJ
cord-001859-d62iuk72	77	15	in	in	IN
cord-001859-d62iuk72	77	16	numerous	numerous	JJ
cord-001859-d62iuk72	77	17	nucleoporins	nucleoporin	NNS
cord-001859-d62iuk72	77	18	(	(	-LRB-
cord-001859-d62iuk72	77	19	Nups	Nups	NNP
cord-001859-d62iuk72	77	20	)	)	-RRB-
cord-001859-d62iuk72	77	21	.	.	.
cord-001859-d62iuk72	78	1	Closed	closed	JJ
cord-001859-d62iuk72	78	2	arrows	arrow	NNS
cord-001859-d62iuk72	78	3	point	point	VBP
cord-001859-d62iuk72	78	4	to	to	IN
cord-001859-d62iuk72	78	5	Nups	Nups	NNP
cord-001859-d62iuk72	78	6	that	that	WDT
cord-001859-d62iuk72	78	7	were	be	VBD
cord-001859-d62iuk72	78	8	only	only	RB
cord-001859-d62iuk72	78	9	detected	detect	VBN
cord-001859-d62iuk72	78	10	by	by	IN
cord-001859-d62iuk72	78	11	MAb414	MAb414	NNS
cord-001859-d62iuk72	78	12	after	after	IN
cord-001859-d62iuk72	78	13	NE	NE	NNP
cord-001859-d62iuk72	78	14	enrichment	enrichment	NN
cord-001859-d62iuk72	78	15	.	.	.
cord-001859-d62iuk72	79	1	Open	open	JJ
cord-001859-d62iuk72	79	2	arrow	arrow	NN
cord-001859-d62iuk72	79	3	points	point	NNS
cord-001859-d62iuk72	79	4	to	to	IN
cord-001859-d62iuk72	79	5	a	a	DT
cord-001859-d62iuk72	79	6	nucleoporin	nucleoporin	NNP
cord-001859-d62iuk72	79	7	lost	lose	VBN
cord-001859-d62iuk72	79	8	during	during	IN
cord-001859-d62iuk72	79	9	NE	NE	NNP
cord-001859-d62iuk72	79	10	enrichment	enrichment	NN
cord-001859-d62iuk72	79	11	.	.	.
cord-001859-d62iuk72	80	1	Several	several	JJ
cord-001859-d62iuk72	80	2	FG	FG	NNP
cord-001859-d62iuk72	80	3	Nups	Nups	NNP
cord-001859-d62iuk72	80	4	,	,	,
cord-001859-d62iuk72	80	5	together	together	RB
cord-001859-d62iuk72	80	6	with	with	IN
cord-001859-d62iuk72	80	7	Nup160	nup160	ADD
cord-001859-d62iuk72	80	8	,	,	,
cord-001859-d62iuk72	80	9	histone	histone	NN
cord-001859-d62iuk72	80	10	H3	H3	NNP
cord-001859-d62iuk72	80	11	and	and	CC
cord-001859-d62iuk72	80	12	lamin	lamin	NN
cord-001859-d62iuk72	80	13	B1	b1	NN
cord-001859-d62iuk72	80	14	were	be	VBD
cord-001859-d62iuk72	80	15	all	all	RB
cord-001859-d62iuk72	80	16	markedly	markedly	RB
cord-001859-d62iuk72	80	17	enriched	enrich	VBN
cord-001859-d62iuk72	80	18	in	in	IN
cord-001859-d62iuk72	80	19	the	the	DT
cord-001859-d62iuk72	80	20	NE	NE	NNP
cord-001859-d62iuk72	80	21	fractions	fraction	NNS
cord-001859-d62iuk72	80	22	compared	compare	VBN
cord-001859-d62iuk72	80	23	with	with	IN
cord-001859-d62iuk72	80	24	WC	WC	NNP
cord-001859-d62iuk72	80	25	fractions	fraction	NNS
cord-001859-d62iuk72	80	26	.	.	.
cord-001859-d62iuk72	81	1	The	the	DT
cord-001859-d62iuk72	81	2	nucleolar	nucleolar	JJ
cord-001859-d62iuk72	81	3	proteins	protein	NNS
cord-001859-d62iuk72	81	4	B-23	B-23	NNP
cord-001859-d62iuk72	81	5	and	and	CC
cord-001859-d62iuk72	81	6	C-23	C-23	NNP
cord-001859-d62iuk72	81	7	and	and	CC
cord-001859-d62iuk72	81	8	the	the	DT
cord-001859-d62iuk72	81	9	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	81	10	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	81	11	protein	protein	NN
cord-001859-d62iuk72	81	12	were	be	VBD
cord-001859-d62iuk72	81	13	all	all	DT
cord-001859-d62iuk72	81	14	decreased	decrease	VBN
cord-001859-d62iuk72	81	15	in	in	IN
cord-001859-d62iuk72	81	16	NEs	nes	JJ
cord-001859-d62iuk72	81	17	fractions	fraction	NNS
cord-001859-d62iuk72	81	18	indicating	indicate	VBG
cord-001859-d62iuk72	81	19	correct	correct	JJ
cord-001859-d62iuk72	81	20	subcellular	subcellular	JJ
cord-001859-d62iuk72	81	21	fractionation	fractionation	NN
cord-001859-d62iuk72	81	22	.	.	.
cord-001859-d62iuk72	82	1	The	the	DT
cord-001859-d62iuk72	82	2	viral	viral	JJ
cord-001859-d62iuk72	82	3	RTC	RTC	NNP
cord-001859-d62iuk72	82	4	-	-	HYPH
cord-001859-d62iuk72	82	5	associated	associate	VBN
cord-001859-d62iuk72	82	6	ORF57	ORF57	NNP
cord-001859-d62iuk72	82	7	and	and	CC
cord-001859-d62iuk72	82	8	RTA	RTA	NNP
cord-001859-d62iuk72	82	9	proteins	protein	NNS
cord-001859-d62iuk72	82	10	were	be	VBD
cord-001859-d62iuk72	82	11	used	use	VBN
cord-001859-d62iuk72	82	12	to	to	TO
cord-001859-d62iuk72	82	13	monitor	monitor	VB
cord-001859-d62iuk72	82	14	lytic	lytic	JJ
cord-001859-d62iuk72	82	15	reactivation	reactivation	NN
cord-001859-d62iuk72	82	16	and	and	CC
cord-001859-d62iuk72	82	17	assess	assess	VB
cord-001859-d62iuk72	82	18	RTC	RTC	NNP
cord-001859-d62iuk72	82	19	enrichment	enrichment	NN
cord-001859-d62iuk72	82	20	.	.	.
cord-001859-d62iuk72	83	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	83	2	antibody	antibody	NN
cord-001859-d62iuk72	83	3	detected	detect	VBD
cord-001859-d62iuk72	83	4	both	both	CC
cord-001859-d62iuk72	83	5	full	full	JJ
cord-001859-d62iuk72	83	6	length	length	NN
cord-001859-d62iuk72	84	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	84	2	protein	protein	NN
cord-001859-d62iuk72	84	3	(	(	-LRB-
cord-001859-d62iuk72	84	4	FL	FL	NNP
cord-001859-d62iuk72	84	5	-	-	HYPH
cord-001859-d62iuk72	84	6	ORF57	ORF57	NNP
cord-001859-d62iuk72	84	7	)	)	-RRB-
cord-001859-d62iuk72	84	8	and	and	CC
cord-001859-d62iuk72	84	9	the	the	DT
cord-001859-d62iuk72	84	10	caspase-7-cleaved	caspase-7-cleaved	JJ
cord-001859-d62iuk72	85	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	86	1	(	(	-LRB-
cord-001859-d62iuk72	86	2	CL	CL	NNP
cord-001859-d62iuk72	86	3	-	-	HYPH
cord-001859-d62iuk72	86	4	ORF57	ORF57	NNP
cord-001859-d62iuk72	86	5	)	)	-RRB-
cord-001859-d62iuk72	86	6	.	.	.
cord-001859-d62iuk72	87	1	prior	prior	RB
cord-001859-d62iuk72	87	2	to	to	IN
cord-001859-d62iuk72	87	3	RTC	RTC	NNP
cord-001859-d62iuk72	87	4	formation	formation	NN
cord-001859-d62iuk72	87	5	(	(	-LRB-
cord-001859-d62iuk72	87	6	Fig	Fig	NNP
cord-001859-d62iuk72	87	7	2Aii	2aii	NN
cord-001859-d62iuk72	87	8	)	)	-RRB-
cord-001859-d62iuk72	87	9	.	.	.
cord-001859-d62iuk72	88	1	In	in	IN
cord-001859-d62iuk72	88	2	contrast	contrast	NN
cord-001859-d62iuk72	88	3	,	,	,
cord-001859-d62iuk72	88	4	at	at	IN
cord-001859-d62iuk72	88	5	later	later	JJ
cord-001859-d62iuk72	88	6	reactivation	reactivation	NN
cord-001859-d62iuk72	88	7	time	time	NN
cord-001859-d62iuk72	88	8	points	point	NNS
cord-001859-d62iuk72	88	9	(	(	-LRB-
cord-001859-d62iuk72	88	10	20	20	CD
cord-001859-d62iuk72	88	11	h	h	NN
cord-001859-d62iuk72	88	12	)	)	-RRB-
cord-001859-d62iuk72	88	13	,	,	,
cord-001859-d62iuk72	88	14	in	in	IN
cord-001859-d62iuk72	88	15	which	which	WDT
cord-001859-d62iuk72	88	16	RTA	RTA	NNP
cord-001859-d62iuk72	88	17	was	be	VBD
cord-001859-d62iuk72	88	18	organised	organise	VBN
cord-001859-d62iuk72	88	19	into	into	IN
cord-001859-d62iuk72	88	20	small	small	JJ
cord-001859-d62iuk72	88	21	viral	viral	JJ
cord-001859-d62iuk72	88	22	RTCs	rtc	NNS
cord-001859-d62iuk72	88	23	peripherally	peripherally	RB
cord-001859-d62iuk72	88	24	located	locate	VBN
cord-001859-d62iuk72	88	25	in	in	IN
cord-001859-d62iuk72	88	26	the	the	DT
cord-001859-d62iuk72	88	27	nucleus	nucleus	NN
cord-001859-d62iuk72	88	28	,	,	,
cord-001859-d62iuk72	88	29	numerous	numerous	JJ
cord-001859-d62iuk72	88	30	nuclear	nuclear	JJ
cord-001859-d62iuk72	88	31	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	88	32	foci	focus	NNS
cord-001859-d62iuk72	88	33	that	that	WDT
cord-001859-d62iuk72	88	34	were	be	VBD
cord-001859-d62iuk72	88	35	predominantly	predominantly	RB
cord-001859-d62iuk72	88	36	adjacent	adjacent	JJ
cord-001859-d62iuk72	88	37	to	to	IN
cord-001859-d62iuk72	88	38	RTCs	rtc	NNS
cord-001859-d62iuk72	88	39	were	be	VBD
cord-001859-d62iuk72	88	40	observed	observe	VBN
cord-001859-d62iuk72	88	41	(	(	-LRB-
cord-001859-d62iuk72	88	42	Fig	Fig	NNP
cord-001859-d62iuk72	88	43	2Aiii	2aiii	CD
cord-001859-d62iuk72	88	44	)	)	-RRB-
cord-001859-d62iuk72	88	45	.	.	.
cord-001859-d62iuk72	89	1	During	during	IN
cord-001859-d62iuk72	89	2	late	late	JJ
cord-001859-d62iuk72	89	3	reactivation	reactivation	NN
cord-001859-d62iuk72	89	4	time	time	NN
cord-001859-d62iuk72	89	5	points	point	NNS
cord-001859-d62iuk72	89	6	(	(	-LRB-
cord-001859-d62iuk72	89	7	26	26	CD
cord-001859-d62iuk72	89	8	h	h	NN
cord-001859-d62iuk72	89	9	)	)	-RRB-
cord-001859-d62iuk72	89	10	,	,	,
cord-001859-d62iuk72	89	11	cellular	cellular	JJ
cord-001859-d62iuk72	89	12	chromatin	chromatin	NN
cord-001859-d62iuk72	89	13	was	be	VBD
cord-001859-d62iuk72	89	14	marginalised	marginalise	VBN
cord-001859-d62iuk72	89	15	to	to	IN
cord-001859-d62iuk72	89	16	the	the	DT
cord-001859-d62iuk72	89	17	nuclear	nuclear	JJ
cord-001859-d62iuk72	89	18	periphery	periphery	NN
cord-001859-d62iuk72	89	19	(	(	-LRB-
cord-001859-d62iuk72	89	20	Fig	fig	NN
cord-001859-d62iuk72	89	21	2Aiv	2aiv	CD
cord-001859-d62iuk72	89	22	,	,	,
cord-001859-d62iuk72	89	23	nucleus	nucleus	NN
cord-001859-d62iuk72	89	24	highlighted	highlight	VBN
cord-001859-d62iuk72	89	25	in	in	IN
cord-001859-d62iuk72	89	26	yellow	yellow	JJ
cord-001859-d62iuk72	89	27	)	)	-RRB-
cord-001859-d62iuk72	89	28	and	and	CC
cord-001859-d62iuk72	89	29	larger	large	JJR
cord-001859-d62iuk72	89	30	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	89	31	foci	foci	NN
cord-001859-d62iuk72	89	32	avidly	avidly	RB
cord-001859-d62iuk72	89	33	accumulated	accumulate	VBN
cord-001859-d62iuk72	89	34	within	within	IN
cord-001859-d62iuk72	89	35	these	these	DT
cord-001859-d62iuk72	89	36	fully	fully	RB
cord-001859-d62iuk72	89	37	-	-	HYPH
cord-001859-d62iuk72	89	38	developed	develop	VBN
cord-001859-d62iuk72	89	39	RTCs	rtc	NNS
cord-001859-d62iuk72	89	40	(	(	-LRB-
cord-001859-d62iuk72	89	41	Fig	fig	NN
cord-001859-d62iuk72	89	42	2Aiv	2aiv	CD
cord-001859-d62iuk72	89	43	)	)	-RRB-
cord-001859-d62iuk72	89	44	.	.	.
cord-001859-d62iuk72	90	1	Reduced	reduced	JJ
cord-001859-d62iuk72	90	2	levels	level	NNS
cord-001859-d62iuk72	90	3	of	of	IN
cord-001859-d62iuk72	90	4	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	90	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	90	6	were	be	VBD
cord-001859-d62iuk72	90	7	also	also	RB
cord-001859-d62iuk72	90	8	observed	observe	VBN
cord-001859-d62iuk72	90	9	at	at	IN
cord-001859-d62iuk72	90	10	this	this	DT
cord-001859-d62iuk72	90	11	time	time	NN
cord-001859-d62iuk72	90	12	point	point	NN
cord-001859-d62iuk72	90	13	(	(	-LRB-
cord-001859-d62iuk72	90	14	Fig	fig	NN
cord-001859-d62iuk72	90	15	2Aiv	2aiv	CD
cord-001859-d62iuk72	90	16	arrows	arrow	NNS
cord-001859-d62iuk72	90	17	)	)	-RRB-
cord-001859-d62iuk72	90	18	,	,	,
cord-001859-d62iuk72	90	19	suggesting	suggest	VBG
cord-001859-d62iuk72	90	20	that	that	IN
cord-001859-d62iuk72	90	21	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	90	22	is	be	VBZ
cord-001859-d62iuk72	90	23	redistributed	redistribute	VBN
cord-001859-d62iuk72	90	24	from	from	IN
cord-001859-d62iuk72	90	25	the	the	DT
cord-001859-d62iuk72	90	26	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	90	27	to	to	IN
cord-001859-d62iuk72	90	28	the	the	DT
cord-001859-d62iuk72	90	29	nucleus	nucleus	NN
cord-001859-d62iuk72	90	30	during	during	IN
cord-001859-d62iuk72	90	31	KSHV	KSHV	NNP
cord-001859-d62iuk72	90	32	lytic	lytic	JJ
cord-001859-d62iuk72	90	33	replication	replication	NN
cord-001859-d62iuk72	90	34	.	.	.
cord-001859-d62iuk72	91	1	This	this	DT
cord-001859-d62iuk72	91	2	is	be	VBZ
cord-001859-d62iuk72	91	3	further	further	RB
cord-001859-d62iuk72	91	4	supported	support	VBN
cord-001859-d62iuk72	91	5	by	by	IN
cord-001859-d62iuk72	91	6	the	the	DT
cord-001859-d62iuk72	91	7	fact	fact	NN
cord-001859-d62iuk72	91	8	that	that	IN
cord-001859-d62iuk72	91	9	fractionation	fractionation	NN
cord-001859-d62iuk72	91	10	of	of	IN
cord-001859-d62iuk72	91	11	TREx	TREx	NNS
cord-001859-d62iuk72	91	12	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	91	13	cells	cell	NNS
cord-001859-d62iuk72	91	14	into	into	IN
cord-001859-d62iuk72	91	15	nuclear	nuclear	JJ
cord-001859-d62iuk72	91	16	(	(	-LRB-
cord-001859-d62iuk72	91	17	N	n	NN
cord-001859-d62iuk72	91	18	)	)	-RRB-
cord-001859-d62iuk72	91	19	and	and	CC
cord-001859-d62iuk72	91	20	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	91	21	(	(	-LRB-
cord-001859-d62iuk72	91	22	C	c	NN
cord-001859-d62iuk72	91	23	)	)	-RRB-
cord-001859-d62iuk72	91	24	fractions	fraction	NNS
cord-001859-d62iuk72	91	25	displayed	display	VBD
cord-001859-d62iuk72	91	26	an	an	DT
cord-001859-d62iuk72	91	27	enrichment	enrichment	NN
cord-001859-d62iuk72	91	28	of	of	IN
cord-001859-d62iuk72	91	29	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	91	30	in	in	IN
cord-001859-d62iuk72	91	31	the	the	DT
cord-001859-d62iuk72	91	32	nuclei	nucleus	NNS
cord-001859-d62iuk72	91	33	of	of	IN
cord-001859-d62iuk72	91	34	reactivated	reactivate	VBN
cord-001859-d62iuk72	91	35	cells	cell	NNS
cord-001859-d62iuk72	91	36	which	which	WDT
cord-001859-d62iuk72	91	37	occurred	occur	VBD
cord-001859-d62iuk72	91	38	without	without	IN
cord-001859-d62iuk72	91	39	a	a	DT
cord-001859-d62iuk72	91	40	noticeable	noticeable	JJ
cord-001859-d62iuk72	91	41	increase	increase	NN
cord-001859-d62iuk72	91	42	in	in	IN
cord-001859-d62iuk72	91	43	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	91	44	protein	protein	NN
cord-001859-d62iuk72	91	45	levels	level	NNS
cord-001859-d62iuk72	91	46	in	in	IN
cord-001859-d62iuk72	91	47	whole	whole	JJ
cord-001859-d62iuk72	91	48	cell	cell	NN
cord-001859-d62iuk72	91	49	(	(	-LRB-
cord-001859-d62iuk72	91	50	WC	WC	NNP
cord-001859-d62iuk72	91	51	)	)	-RRB-
cord-001859-d62iuk72	91	52	lysates	lysates	NNP
cord-001859-d62iuk72	91	53	(	(	-LRB-
cord-001859-d62iuk72	91	54	Fig	Fig	NNP
cord-001859-d62iuk72	91	55	2B	2b	CD
cord-001859-d62iuk72	91	56	)	)	-RRB-
cord-001859-d62iuk72	91	57	.	.	.
cord-001859-d62iuk72	92	1	Due	due	IN
cord-001859-d62iuk72	92	2	to	to	IN
cord-001859-d62iuk72	92	3	the	the	DT
cord-001859-d62iuk72	92	4	observed	observed	JJ
cord-001859-d62iuk72	92	5	redistribution	redistribution	NN
cord-001859-d62iuk72	92	6	of	of	IN
cord-001859-d62iuk72	92	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	92	8	to	to	IN
cord-001859-d62iuk72	92	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	92	10	RTCs	rtc	NNS
cord-001859-d62iuk72	92	11	,	,	,
cord-001859-d62iuk72	92	12	further	further	JJ
cord-001859-d62iuk72	92	13	co	co	NN
cord-001859-d62iuk72	92	14	-	-	JJ
cord-001859-d62iuk72	92	15	localization	localization	JJ
cord-001859-d62iuk72	92	16	studies	study	NNS
cord-001859-d62iuk72	92	17	between	between	IN
cord-001859-d62iuk72	92	18	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	92	19	and	and	CC
cord-001859-d62iuk72	92	20	the	the	DT
cord-001859-d62iuk72	92	21	sites	site	NNS
cord-001859-d62iuk72	92	22	of	of	IN
cord-001859-d62iuk72	92	23	viral	viral	JJ
cord-001859-d62iuk72	92	24	DNA	dna	NN
cord-001859-d62iuk72	92	25	replication	replication	NN
cord-001859-d62iuk72	92	26	were	be	VBD
cord-001859-d62iuk72	92	27	performed	perform	VBN
cord-001859-d62iuk72	92	28	in	in	IN
cord-001859-d62iuk72	92	29	TREx	TREx	NNS
cord-001859-d62iuk72	92	30	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	92	31	cells	cell	NNS
cord-001859-d62iuk72	92	32	.	.	.
cord-001859-d62iuk72	93	1	Here	here	RB
cord-001859-d62iuk72	93	2	,	,	,
cord-001859-d62iuk72	93	3	cells	cell	NNS
cord-001859-d62iuk72	93	4	were	be	VBD
cord-001859-d62iuk72	93	5	triple	triple	RB
cord-001859-d62iuk72	93	6	-	-	HYPH
cord-001859-d62iuk72	93	7	labelled	label	VBN
cord-001859-d62iuk72	93	8	with	with	IN
cord-001859-d62iuk72	93	9	Click	click	NN
cord-001859-d62iuk72	93	10	-	-	:
cord-001859-d62iuk72	93	11	iT	it	PRP
cord-001859-d62iuk72	94	1	EdU	EdU	NNP
cord-001859-d62iuk72	94	2	Alexa	Alexa	NNP
cord-001859-d62iuk72	94	3	Fluor	Fluor	NNP
cord-001859-d62iuk72	94	4	647	647	CD
cord-001859-d62iuk72	94	5	and	and	CC
cord-001859-d62iuk72	94	6	antibodies	antibody	NNS
cord-001859-d62iuk72	94	7	specific	specific	JJ
cord-001859-d62iuk72	94	8	for	for	IN
cord-001859-d62iuk72	94	9	RTA	RTA	NNP
cord-001859-d62iuk72	94	10	and	and	CC
cord-001859-d62iuk72	94	11	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	94	12	.	.	.
cord-001859-d62iuk72	95	1	In	in	IN
cord-001859-d62iuk72	95	2	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	95	3	cells	cell	NNS
cord-001859-d62iuk72	95	4	,	,	,
cord-001859-d62iuk72	95	5	newly	newly	RB
cord-001859-d62iuk72	95	6	synthesized	synthesize	VBN
cord-001859-d62iuk72	95	7	cellular	cellular	JJ
cord-001859-d62iuk72	95	8	DNA	dna	NN
cord-001859-d62iuk72	95	9	during	during	IN
cord-001859-d62iuk72	95	10	mid	mid	NNP
cord-001859-d62iuk72	95	11	-	-	NNP
cord-001859-d62iuk72	95	12	S	s	NN
cord-001859-d62iuk72	95	13	-	-	HYPH
cord-001859-d62iuk72	95	14	phase	phase	NN
cord-001859-d62iuk72	95	15	(	(	-LRB-
cord-001859-d62iuk72	95	16	EdU	edu	NN
cord-001859-d62iuk72	95	17	incorporated	incorporate	VBN
cord-001859-d62iuk72	95	18	)	)	-RRB-
cord-001859-d62iuk72	95	19	occurred	occur	VBD
cord-001859-d62iuk72	95	20	mainly	mainly	RB
cord-001859-d62iuk72	95	21	at	at	IN
cord-001859-d62iuk72	95	22	the	the	DT
cord-001859-d62iuk72	95	23	nuclear	nuclear	JJ
cord-001859-d62iuk72	95	24	periphery	periphery	NN
cord-001859-d62iuk72	95	25	as	as	IN
cord-001859-d62iuk72	95	26	previously	previously	RB
cord-001859-d62iuk72	95	27	observed	observe	VBN
cord-001859-d62iuk72	95	28	in	in	IN
cord-001859-d62iuk72	95	29	other	other	JJ
cord-001859-d62iuk72	95	30	cell	cell	NN
cord-001859-d62iuk72	95	31	types	type	NNS
cord-001859-d62iuk72	95	32	[	[	-LRB-
cord-001859-d62iuk72	95	33	49	49	CD
cord-001859-d62iuk72	95	34	,	,	,
cord-001859-d62iuk72	95	35	50	50	CD
cord-001859-d62iuk72	95	36	]	]	-RRB-
cord-001859-d62iuk72	96	1	(	(	-LRB-
cord-001859-d62iuk72	96	2	Fig	Fig	NNP
cord-001859-d62iuk72	96	3	2Ci	2ci	CD
cord-001859-d62iuk72	96	4	)	)	-RRB-
cord-001859-d62iuk72	96	5	.	.	.
cord-001859-d62iuk72	97	1	During	during	IN
cord-001859-d62iuk72	97	2	early	early	JJ
cord-001859-d62iuk72	97	3	reactivation	reactivation	NN
cord-001859-d62iuk72	97	4	,	,	,
cord-001859-d62iuk72	97	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	97	6	was	be	VBD
cord-001859-d62iuk72	97	7	adjacent	adjacent	JJ
cord-001859-d62iuk72	97	8	to	to	IN
cord-001859-d62iuk72	97	9	RTA	RTA	NNP
cord-001859-d62iuk72	97	10	which	which	WDT
cord-001859-d62iuk72	97	11	was	be	VBD
cord-001859-d62iuk72	97	12	present	present	JJ
cord-001859-d62iuk72	97	13	in	in	IN
cord-001859-d62iuk72	97	14	small	small	JJ
cord-001859-d62iuk72	97	15	viral	viral	JJ
cord-001859-d62iuk72	97	16	RTCs	rtc	NNS
cord-001859-d62iuk72	97	17	containing	contain	VBG
cord-001859-d62iuk72	97	18	actively	actively	RB
cord-001859-d62iuk72	97	19	replicating	replicate	VBG
cord-001859-d62iuk72	97	20	viral	viral	JJ
cord-001859-d62iuk72	97	21	DNA	dna	NN
cord-001859-d62iuk72	97	22	(	(	-LRB-
cord-001859-d62iuk72	97	23	Fig	Fig	NNP
cord-001859-d62iuk72	97	24	2Cii	2cii	CD
cord-001859-d62iuk72	97	25	arrow	arrow	NN
cord-001859-d62iuk72	97	26	)	)	-RRB-
cord-001859-d62iuk72	97	27	.	.	.
cord-001859-d62iuk72	98	1	At	at	IN
cord-001859-d62iuk72	98	2	this	this	DT
cord-001859-d62iuk72	98	3	stage	stage	NN
cord-001859-d62iuk72	98	4	,	,	,
cord-001859-d62iuk72	98	5	a	a	DT
cord-001859-d62iuk72	98	6	proportion	proportion	NN
cord-001859-d62iuk72	98	7	of	of	IN
cord-001859-d62iuk72	98	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	98	9	also	also	RB
cord-001859-d62iuk72	98	10	co	co	VBD
cord-001859-d62iuk72	98	11	-	-	JJ
cord-001859-d62iuk72	98	12	localised	localised	JJ
cord-001859-d62iuk72	98	13	with	with	IN
cord-001859-d62iuk72	98	14	RTA	RTA	NNP
cord-001859-d62iuk72	98	15	(	(	-LRB-
cord-001859-d62iuk72	98	16	Fig	Fig	NNP
cord-001859-d62iuk72	98	17	2Cii	2cii	NN
cord-001859-d62iuk72	98	18	'	'	''
cord-001859-d62iuk72	98	19	)	)	-RRB-
cord-001859-d62iuk72	98	20	.	.	.
cord-001859-d62iuk72	99	1	During	during	IN
cord-001859-d62iuk72	99	2	late	late	JJ
cord-001859-d62iuk72	99	3	reactivation	reactivation	NN
cord-001859-d62iuk72	99	4	,	,	,
cord-001859-d62iuk72	99	5	when	when	WRB
cord-001859-d62iuk72	99	6	cellular	cellular	JJ
cord-001859-d62iuk72	99	7	chromatin	chromatin	NN
cord-001859-d62iuk72	99	8	was	be	VBD
cord-001859-d62iuk72	99	9	marginalised	marginalise	VBN
cord-001859-d62iuk72	99	10	,	,	,
cord-001859-d62iuk72	99	11	much	much	RB
cord-001859-d62iuk72	99	12	larger	large	JJR
cord-001859-d62iuk72	99	13	RTCs	rtc	NNS
cord-001859-d62iuk72	99	14	were	be	VBD
cord-001859-d62iuk72	99	15	visible	visible	JJ
cord-001859-d62iuk72	99	16	and	and	CC
cord-001859-d62iuk72	99	17	newly	newly	RB
cord-001859-d62iuk72	99	18	synthesized	synthesize	VBN
cord-001859-d62iuk72	99	19	cellular	cellular	JJ
cord-001859-d62iuk72	99	20	DNA	dna	NN
cord-001859-d62iuk72	99	21	was	be	VBD
cord-001859-d62iuk72	99	22	not	not	RB
cord-001859-d62iuk72	99	23	apparent	apparent	JJ
cord-001859-d62iuk72	99	24	,	,	,
cord-001859-d62iuk72	99	25	here	here	RB
cord-001859-d62iuk72	99	26	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	99	27	completely	completely	RB
cord-001859-d62iuk72	99	28	co	co	VBD
cord-001859-d62iuk72	99	29	-	-	JJ
cord-001859-d62iuk72	99	30	localised	localised	JJ
cord-001859-d62iuk72	99	31	with	with	IN
cord-001859-d62iuk72	99	32	newly	newly	RB
cord-001859-d62iuk72	99	33	synthesized	synthesize	VBN
cord-001859-d62iuk72	99	34	viral	viral	JJ
cord-001859-d62iuk72	99	35	DNA	DNA	NNP
cord-001859-d62iuk72	99	36	and	and	CC
cord-001859-d62iuk72	99	37	RTA	RTA	NNP
cord-001859-d62iuk72	99	38	(	(	-LRB-
cord-001859-d62iuk72	99	39	Fig	Fig	NNP
cord-001859-d62iuk72	99	40	2Ciii	2ciii	CD
cord-001859-d62iuk72	99	41	and	and	CC
cord-001859-d62iuk72	99	42	2Ciii	2Ciii	NNP
cord-001859-d62iuk72	99	43	'	'	''
cord-001859-d62iuk72	99	44	)	)	-RRB-
cord-001859-d62iuk72	99	45	.	.	.
cord-001859-d62iuk72	100	1	The	the	DT
cord-001859-d62iuk72	100	2	location	location	NN
cord-001859-d62iuk72	100	3	of	of	IN
cord-001859-d62iuk72	100	4	the	the	DT
cord-001859-d62iuk72	100	5	other	other	JJ
cord-001859-d62iuk72	100	6	two	two	CD
cord-001859-d62iuk72	100	7	main	main	JJ
cord-001859-d62iuk72	100	8	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	100	9	isoforms	isoform	NNS
cord-001859-d62iuk72	100	10	(	(	-LRB-
cord-001859-d62iuk72	100	11	iHsp70	iHsp70	NFP
cord-001859-d62iuk72	100	12	and	and	CC
cord-001859-d62iuk72	100	13	Grp78	Grp78	NNP
cord-001859-d62iuk72	100	14	)	)	-RRB-
cord-001859-d62iuk72	100	15	during	during	IN
cord-001859-d62iuk72	100	16	KSHV	KSHV	NNP
cord-001859-d62iuk72	100	17	lytic	lytic	JJ
cord-001859-d62iuk72	100	18	replication	replication	NN
cord-001859-d62iuk72	100	19	was	be	VBD
cord-001859-d62iuk72	100	20	also	also	RB
cord-001859-d62iuk72	100	21	investigated	investigate	VBN
cord-001859-d62iuk72	100	22	by	by	IN
cord-001859-d62iuk72	100	23	indirect	indirect	JJ
cord-001859-d62iuk72	100	24	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	100	25	microscopy	microscopy	NN
cord-001859-d62iuk72	100	26	.	.	.
cord-001859-d62iuk72	101	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	101	2	was	be	VBD
cord-001859-d62iuk72	101	3	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	101	4	in	in	IN
cord-001859-d62iuk72	101	5	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	101	6	TREx	TREx	NNS
cord-001859-d62iuk72	101	7	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	101	8	cells	cell	NNS
cord-001859-d62iuk72	101	9	(	(	-LRB-
cord-001859-d62iuk72	101	10	S1Ai	s1ai	CD
cord-001859-d62iuk72	101	11	Fig	Fig	NNP
cord-001859-d62iuk72	101	12	)	)	-RRB-
cord-001859-d62iuk72	101	13	,	,	,
cord-001859-d62iuk72	101	14	in	in	IN
cord-001859-d62iuk72	101	15	contrast	contrast	NN
cord-001859-d62iuk72	101	16	,	,	,
cord-001859-d62iuk72	101	17	an	an	DT
cord-001859-d62iuk72	101	18	increase	increase	NN
cord-001859-d62iuk72	101	19	in	in	IN
cord-001859-d62iuk72	101	20	nuclear	nuclear	JJ
cord-001859-d62iuk72	101	21	iHsp70	iHsp70	.
cord-001859-d62iuk72	101	22	labelling	labelling	NN
cord-001859-d62iuk72	101	23	was	be	VBD
cord-001859-d62iuk72	101	24	observed	observe	VBN
cord-001859-d62iuk72	101	25	in	in	IN
cord-001859-d62iuk72	101	26	reactivated	reactivate	VBN
cord-001859-d62iuk72	101	27	cells	cell	NNS
cord-001859-d62iuk72	101	28	,	,	,
cord-001859-d62iuk72	101	29	which	which	WDT
cord-001859-d62iuk72	101	30	displayed	display	VBD
cord-001859-d62iuk72	101	31	similar	similar	JJ
cord-001859-d62iuk72	101	32	chaperone	chaperone	NN
cord-001859-d62iuk72	101	33	foci	foci	NN
cord-001859-d62iuk72	101	34	as	as	IN
cord-001859-d62iuk72	101	35	those	those	DT
cord-001859-d62iuk72	101	36	seen	see	VBN
cord-001859-d62iuk72	101	37	during	during	IN
cord-001859-d62iuk72	101	38	early	early	JJ
cord-001859-d62iuk72	101	39	reactivation	reactivation	NN
cord-001859-d62iuk72	101	40	for	for	IN
cord-001859-d62iuk72	101	41	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	101	42	(	(	-LRB-
cord-001859-d62iuk72	101	43	S1Aii	S1Aii	NNP
cord-001859-d62iuk72	101	44	Fig	Fig	NNP
cord-001859-d62iuk72	101	45	)	)	-RRB-
cord-001859-d62iuk72	101	46	.	.	.
cord-001859-d62iuk72	102	1	Occasionally	occasionally	RB
cord-001859-d62iuk72	102	2	,	,	,
cord-001859-d62iuk72	102	3	cells	cell	NNS
cord-001859-d62iuk72	102	4	displayed	display	VBD
cord-001859-d62iuk72	102	5	RTCs	RTCs	NNP
cord-001859-d62iuk72	102	6	completely	completely	RB
cord-001859-d62iuk72	102	7	filled	fill	VBN
cord-001859-d62iuk72	102	8	by	by	IN
cord-001859-d62iuk72	102	9	iHsp70	iHsp70	.
cord-001859-d62iuk72	103	1	(	(	-LRB-
cord-001859-d62iuk72	103	2	S1Aiii	S1Aiii	NNP
cord-001859-d62iuk72	103	3	and	and	CC
cord-001859-d62iuk72	104	1	S1Aiv	S1Aiv	NNP
cord-001859-d62iuk72	104	2	Fig	Fig	NNP
cord-001859-d62iuk72	104	3	,	,	,
cord-001859-d62iuk72	104	4	asterisks	asterisk	NNS
cord-001859-d62iuk72	104	5	)	)	-RRB-
cord-001859-d62iuk72	104	6	.	.	.
cord-001859-d62iuk72	105	1	Large	large	JJ
cord-001859-d62iuk72	105	2	iHsp70	ihsp70	IN
cord-001859-d62iuk72	105	3	foci	foci	NN
cord-001859-d62iuk72	105	4	positioned	position	VBN
cord-001859-d62iuk72	105	5	adjacent	adjacent	JJ
cord-001859-d62iuk72	105	6	to	to	IN
cord-001859-d62iuk72	105	7	RTCs	rtc	NNS
cord-001859-d62iuk72	105	8	were	be	VBD
cord-001859-d62iuk72	105	9	also	also	RB
cord-001859-d62iuk72	105	10	seen	see	VBN
cord-001859-d62iuk72	105	11	in	in	IN
cord-001859-d62iuk72	105	12	reactivated	reactivate	VBN
cord-001859-d62iuk72	105	13	cells	cell	NNS
cord-001859-d62iuk72	105	14	at	at	IN
cord-001859-d62iuk72	105	15	later	later	JJ
cord-001859-d62iuk72	105	16	time	time	NN
cord-001859-d62iuk72	105	17	points	point	NNS
cord-001859-d62iuk72	105	18	(	(	-LRB-
cord-001859-d62iuk72	105	19	S1Aiv	S1Aiv	NNP
cord-001859-d62iuk72	105	20	Fig	Fig	NNP
cord-001859-d62iuk72	105	21	 	 	_SP
cord-001859-d62iuk72	105	22	arrows	arrow	NNS
cord-001859-d62iuk72	105	23	)	)	-RRB-
cord-001859-d62iuk72	105	24	.	.	.
cord-001859-d62iuk72	106	1	Co	co	NN
cord-001859-d62iuk72	106	2	-	-	NN
cord-001859-d62iuk72	106	3	localisation	localisation	NN
cord-001859-d62iuk72	106	4	of	of	IN
cord-001859-d62iuk72	106	5	iHsp70	iHsp70	.
cord-001859-d62iuk72	107	1	with	with	IN
cord-001859-d62iuk72	107	2	actively	actively	RB
cord-001859-d62iuk72	107	3	replicating	replicate	VBG
cord-001859-d62iuk72	107	4	viral	viral	JJ
cord-001859-d62iuk72	107	5	DNA	dna	NN
cord-001859-d62iuk72	107	6	was	be	VBD
cord-001859-d62iuk72	107	7	also	also	RB
cord-001859-d62iuk72	107	8	observed	observe	VBN
cord-001859-d62iuk72	107	9	during	during	IN
cord-001859-d62iuk72	107	10	late	late	JJ
cord-001859-d62iuk72	107	11	reactivation	reactivation	NN
cord-001859-d62iuk72	107	12	(	(	-LRB-
cord-001859-d62iuk72	107	13	S1B	S1B	NNP
cord-001859-d62iuk72	107	14	Fig	Fig	NNP
cord-001859-d62iuk72	107	15	)	)	-RRB-
cord-001859-d62iuk72	107	16	.	.	.
cord-001859-d62iuk72	108	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	108	2	and	and	CC
cord-001859-d62iuk72	108	3	iHsp70	ihsp70	IN
cord-001859-d62iuk72	108	4	nuclear	nuclear	JJ
cord-001859-d62iuk72	108	5	foci	focus	NNS
cord-001859-d62iuk72	108	6	appeared	appear	VBD
cord-001859-d62iuk72	108	7	at	at	IN
cord-001859-d62iuk72	108	8	the	the	DT
cord-001859-d62iuk72	108	9	same	same	JJ
cord-001859-d62iuk72	108	10	time	time	NN
cord-001859-d62iuk72	108	11	as	as	IN
cord-001859-d62iuk72	108	12	KSHV	KSHV	NNP
cord-001859-d62iuk72	108	13	RTCs	rtc	NNS
cord-001859-d62iuk72	108	14	were	be	VBD
cord-001859-d62iuk72	108	15	assembled	assemble	VBN
cord-001859-d62iuk72	108	16	,	,	,
cord-001859-d62iuk72	108	17	suggesting	suggest	VBG
cord-001859-d62iuk72	108	18	that	that	IN
cord-001859-d62iuk72	108	19	these	these	DT
cord-001859-d62iuk72	108	20	chaperones	chaperone	NNS
cord-001859-d62iuk72	108	21	could	could	MD
cord-001859-d62iuk72	108	22	be	be	VB
cord-001859-d62iuk72	108	23	involved	involve	VBN
cord-001859-d62iuk72	108	24	in	in	IN
cord-001859-d62iuk72	108	25	RTC	RTC	NNP
cord-001859-d62iuk72	108	26	assembly	assembly	NN
cord-001859-d62iuk72	108	27	.	.	.
cord-001859-d62iuk72	109	1	Additionally	additionally	RB
cord-001859-d62iuk72	109	2	,	,	,
cord-001859-d62iuk72	109	3	complete	complete	JJ
cord-001859-d62iuk72	109	4	co	co	NN
cord-001859-d62iuk72	109	5	-	-	NN
cord-001859-d62iuk72	109	6	localization	localization	NN
cord-001859-d62iuk72	109	7	of	of	IN
cord-001859-d62iuk72	109	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	109	9	and	and	CC
cord-001859-d62iuk72	109	10	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	109	11	with	with	IN
cord-001859-d62iuk72	109	12	viral	viral	JJ
cord-001859-d62iuk72	109	13	DNA	DNA	NNP
cord-001859-d62iuk72	109	14	indicated	indicate	VBD
cord-001859-d62iuk72	109	15	that	that	IN
cord-001859-d62iuk72	109	16	these	these	DT
cord-001859-d62iuk72	109	17	chaperones	chaperone	NNS
cord-001859-d62iuk72	109	18	could	could	MD
cord-001859-d62iuk72	109	19	also	also	RB
cord-001859-d62iuk72	109	20	participate	participate	VB
cord-001859-d62iuk72	109	21	in	in	IN
cord-001859-d62iuk72	109	22	viral	viral	JJ
cord-001859-d62iuk72	109	23	DNA	dna	NN
cord-001859-d62iuk72	109	24	replication	replication	NN
cord-001859-d62iuk72	109	25	and/or	and/or	CC
cord-001859-d62iuk72	109	26	capsid	capsid	NN
cord-001859-d62iuk72	109	27	assembly	assembly	NN
cord-001859-d62iuk72	109	28	.	.	.
cord-001859-d62iuk72	110	1	In	in	IN
cord-001859-d62iuk72	110	2	contrast	contrast	NN
cord-001859-d62iuk72	110	3	,	,	,
cord-001859-d62iuk72	110	4	the	the	DT
cord-001859-d62iuk72	110	5	endoplasmic	endoplasmic	NN
cord-001859-d62iuk72	110	6	reticulum	reticulum	NN
cord-001859-d62iuk72	110	7	(	(	-LRB-
cord-001859-d62iuk72	110	8	ER	ER	NNP
cord-001859-d62iuk72	110	9	)	)	-RRB-
cord-001859-d62iuk72	110	10	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	110	11	isoform	isoform	NN
cord-001859-d62iuk72	110	12	,	,	,
cord-001859-d62iuk72	110	13	Grp78	Grp78	NNP
cord-001859-d62iuk72	110	14	,	,	,
cord-001859-d62iuk72	110	15	was	be	VBD
cord-001859-d62iuk72	110	16	not	not	RB
cord-001859-d62iuk72	110	17	redistributed	redistribute	VBN
cord-001859-d62iuk72	110	18	in	in	IN
cord-001859-d62iuk72	110	19	reactivated	reactivate	VBN
cord-001859-d62iuk72	110	20	TREx	TREx	NNS
cord-001859-d62iuk72	110	21	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	110	22	cells	cell	NNS
cord-001859-d62iuk72	110	23	(	(	-LRB-
cord-001859-d62iuk72	110	24	S2	S2	NNP
cord-001859-d62iuk72	110	25	Fig	Fig	NNP
cord-001859-d62iuk72	110	26	)	)	-RRB-
cord-001859-d62iuk72	110	27	,	,	,
cord-001859-d62iuk72	110	28	consistent	consistent	JJ
cord-001859-d62iuk72	110	29	with	with	IN
cord-001859-d62iuk72	110	30	its	-PRON-	PRP$
cord-001859-d62iuk72	110	31	ER	ER	NNP
cord-001859-d62iuk72	110	32	retention	retention	NN
cord-001859-d62iuk72	110	33	signal	signal	NN
cord-001859-d62iuk72	110	34	[	[	-LRB-
cord-001859-d62iuk72	110	35	51	51	CD
cord-001859-d62iuk72	110	36	]	]	-RRB-
cord-001859-d62iuk72	110	37	.	.	.
cord-001859-d62iuk72	111	1	Nevertheless	nevertheless	RB
cord-001859-d62iuk72	111	2	,	,	,
cord-001859-d62iuk72	111	3	reactivated	reactivate	VBN
cord-001859-d62iuk72	111	4	cells	cell	NNS
cord-001859-d62iuk72	111	5	seemed	seem	VBD
cord-001859-d62iuk72	111	6	to	to	TO
cord-001859-d62iuk72	111	7	accumulate	accumulate	VB
cord-001859-d62iuk72	111	8	larger	large	JJR
cord-001859-d62iuk72	111	9	amounts	amount	NNS
cord-001859-d62iuk72	111	10	of	of	IN
cord-001859-d62iuk72	111	11	Grp78	Grp78	NNP
cord-001859-d62iuk72	111	12	in	in	IN
cord-001859-d62iuk72	111	13	the	the	DT
cord-001859-d62iuk72	111	14	ER	er	NN
cord-001859-d62iuk72	111	15	.	.	.
cord-001859-d62iuk72	112	1	To	to	TO
cord-001859-d62iuk72	112	2	confirm	confirm	VB
cord-001859-d62iuk72	112	3	these	these	DT
cord-001859-d62iuk72	112	4	results	result	NNS
cord-001859-d62iuk72	112	5	,	,	,
cord-001859-d62iuk72	112	6	immunoflourescence	immunoflourescence	NN
cord-001859-d62iuk72	112	7	studies	study	NNS
cord-001859-d62iuk72	112	8	were	be	VBD
cord-001859-d62iuk72	112	9	also	also	RB
cord-001859-d62iuk72	112	10	performed	perform	VBN
cord-001859-d62iuk72	112	11	using	use	VBG
cord-001859-d62iuk72	112	12	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	112	13	T	T	NNP
cord-001859-d62iuk72	112	14	prior	prior	RB
cord-001859-d62iuk72	112	15	to	to	IN
cord-001859-d62iuk72	112	16	RTC	RTC	NNP
cord-001859-d62iuk72	112	17	formation	formation	NN
cord-001859-d62iuk72	112	18	,	,	,
cord-001859-d62iuk72	112	19	when	when	WRB
cord-001859-d62iuk72	112	20	RTA	RTA	NNP
cord-001859-d62iuk72	112	21	was	be	VBD
cord-001859-d62iuk72	112	22	diffuse	diffuse	JJ
cord-001859-d62iuk72	112	23	in	in	IN
cord-001859-d62iuk72	112	24	the	the	DT
cord-001859-d62iuk72	112	25	nucleus	nucleus	NN
cord-001859-d62iuk72	112	26	(	(	-LRB-
cord-001859-d62iuk72	112	27	ii	ii	NN
cord-001859-d62iuk72	112	28	)	)	-RRB-
cord-001859-d62iuk72	112	29	.	.	.
cord-001859-d62iuk72	113	1	At	at	IN
cord-001859-d62iuk72	113	2	20	20	CD
cord-001859-d62iuk72	113	3	h	h	NN
cord-001859-d62iuk72	113	4	reactivation	reactivation	NN
cord-001859-d62iuk72	113	5	viral	viral	JJ
cord-001859-d62iuk72	113	6	RTA	RTA	NNP
cord-001859-d62iuk72	113	7	was	be	VBD
cord-001859-d62iuk72	113	8	assembled	assemble	VBN
cord-001859-d62iuk72	113	9	into	into	IN
cord-001859-d62iuk72	113	10	incipient	incipient	JJ
cord-001859-d62iuk72	113	11	RTCs	rtc	NNS
cord-001859-d62iuk72	113	12	.	.	.
cord-001859-d62iuk72	114	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	114	2	was	be	VBD
cord-001859-d62iuk72	114	3	not	not	RB
cord-001859-d62iuk72	114	4	detected	detect	VBN
cord-001859-d62iuk72	114	5	in	in	IN
cord-001859-d62iuk72	114	6	the	the	DT
cord-001859-d62iuk72	114	7	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	114	8	and	and	CC
cord-001859-d62iuk72	114	9	instead	instead	RB
cord-001859-d62iuk72	114	10	numerous	numerous	JJ
cord-001859-d62iuk72	114	11	nuclear	nuclear	JJ
cord-001859-d62iuk72	114	12	foci	foci	NN
cord-001859-d62iuk72	114	13	that	that	WDT
cord-001859-d62iuk72	114	14	were	be	VBD
cord-001859-d62iuk72	114	15	positioned	position	VBN
cord-001859-d62iuk72	114	16	predominantly	predominantly	RB
cord-001859-d62iuk72	114	17	adjacent	adjacent	JJ
cord-001859-d62iuk72	114	18	to	to	IN
cord-001859-d62iuk72	114	19	RTCs	rtc	NNS
cord-001859-d62iuk72	114	20	were	be	VBD
cord-001859-d62iuk72	114	21	seen	see	VBN
cord-001859-d62iuk72	114	22	(	(	-LRB-
cord-001859-d62iuk72	114	23	iii	iii	NN
cord-001859-d62iuk72	114	24	)	)	-RRB-
cord-001859-d62iuk72	114	25	.	.	.
cord-001859-d62iuk72	115	1	At	at	IN
cord-001859-d62iuk72	115	2	later	later	JJ
cord-001859-d62iuk72	115	3	reactivation	reactivation	NN
cord-001859-d62iuk72	115	4	times	time	NNS
cord-001859-d62iuk72	115	5	very	very	RB
cord-001859-d62iuk72	115	6	large	large	JJ
cord-001859-d62iuk72	115	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	115	8	foci	focus	NNS
cord-001859-d62iuk72	115	9	were	be	VBD
cord-001859-d62iuk72	115	10	completely	completely	RB
cord-001859-d62iuk72	115	11	recruited	recruit	VBN
cord-001859-d62iuk72	115	12	within	within	IN
cord-001859-d62iuk72	115	13	RTCs	rtc	NNS
cord-001859-d62iuk72	115	14	.	.	.
cord-001859-d62iuk72	116	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	116	2	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	116	3	depletion	depletion	NN
cord-001859-d62iuk72	116	4	is	be	VBZ
cord-001859-d62iuk72	116	5	indicated	indicate	VBN
cord-001859-d62iuk72	116	6	(	(	-LRB-
cord-001859-d62iuk72	116	7	iv	iv	IN
cord-001859-d62iuk72	116	8	arrows	arrow	NNS
cord-001859-d62iuk72	116	9	)	)	-RRB-
cord-001859-d62iuk72	116	10	.	.	.
cord-001859-d62iuk72	117	1	Nucleus	nucleus	NN
cord-001859-d62iuk72	117	2	highlighted	highlight	VBN
cord-001859-d62iuk72	117	3	in	in	IN
cord-001859-d62iuk72	117	4	yellow	yellow	JJ
cord-001859-d62iuk72	117	5	shows	show	VBZ
cord-001859-d62iuk72	117	6	a	a	DT
cord-001859-d62iuk72	117	7	typical	typical	JJ
cord-001859-d62iuk72	117	8	KSHV	KSHV	NNP
cord-001859-d62iuk72	117	9	fully	fully	RB
cord-001859-d62iuk72	117	10	developed	develop	VBN
cord-001859-d62iuk72	117	11	-	-	:
cord-001859-d62iuk72	117	12	RTC	RTC	NNP
cord-001859-d62iuk72	117	13	with	with	IN
cord-001859-d62iuk72	117	14	cellular	cellular	JJ
cord-001859-d62iuk72	117	15	chromatin	chromatin	NN
cord-001859-d62iuk72	117	16	marginalised	marginalise	VBN
cord-001859-d62iuk72	117	17	to	to	IN
cord-001859-d62iuk72	117	18	the	the	DT
cord-001859-d62iuk72	117	19	nuclear	nuclear	JJ
cord-001859-d62iuk72	117	20	periphery	periphery	NN
cord-001859-d62iuk72	117	21	.	.	.
cord-001859-d62iuk72	118	1	(	(	-LRB-
cord-001859-d62iuk72	118	2	B	b	NN
cord-001859-d62iuk72	118	3	)	)	-RRB-
cord-001859-d62iuk72	118	4	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	118	5	(	(	-LRB-
cord-001859-d62iuk72	118	6	-	-	:
cord-001859-d62iuk72	118	7	)	)	-RRB-
cord-001859-d62iuk72	118	8	or	or	CC
cord-001859-d62iuk72	118	9	reactivated	reactivate	VBN
cord-001859-d62iuk72	118	10	for	for	IN
cord-001859-d62iuk72	118	11	26	26	CD
cord-001859-d62iuk72	118	12	h	h	NN
cord-001859-d62iuk72	118	13	(	(	-LRB-
cord-001859-d62iuk72	118	14	+	+	NNS
cord-001859-d62iuk72	118	15	)	)	-RRB-
cord-001859-d62iuk72	118	16	TREx	TREx	NNS
cord-001859-d62iuk72	118	17	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	118	18	cells	cell	NNS
cord-001859-d62iuk72	118	19	were	be	VBD
cord-001859-d62iuk72	118	20	fractionated	fractionate	VBN
cord-001859-d62iuk72	118	21	into	into	IN
cord-001859-d62iuk72	118	22	whole	whole	JJ
cord-001859-d62iuk72	118	23	cell	cell	NN
cord-001859-d62iuk72	118	24	(	(	-LRB-
cord-001859-d62iuk72	118	25	WC	WC	NNP
cord-001859-d62iuk72	118	26	)	)	-RRB-
cord-001859-d62iuk72	118	27	,	,	,
cord-001859-d62iuk72	118	28	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	118	29	(	(	-LRB-
cord-001859-d62iuk72	118	30	C	C	NNP
cord-001859-d62iuk72	118	31	)	)	-RRB-
cord-001859-d62iuk72	118	32	and	and	CC
cord-001859-d62iuk72	118	33	nuclear	nuclear	JJ
cord-001859-d62iuk72	118	34	(	(	-LRB-
cord-001859-d62iuk72	118	35	N	n	NN
cord-001859-d62iuk72	118	36	)	)	-RRB-
cord-001859-d62iuk72	118	37	fractions	fraction	NNS
cord-001859-d62iuk72	118	38	.	.	.
cord-001859-d62iuk72	119	1	Equal	equal	JJ
cord-001859-d62iuk72	119	2	amounts	amount	NNS
cord-001859-d62iuk72	119	3	of	of	IN
cord-001859-d62iuk72	119	4	total	total	JJ
cord-001859-d62iuk72	119	5	protein	protein	NN
cord-001859-d62iuk72	119	6	from	from	IN
cord-001859-d62iuk72	119	7	each	each	DT
cord-001859-d62iuk72	119	8	fraction	fraction	NN
cord-001859-d62iuk72	119	9	were	be	VBD
cord-001859-d62iuk72	119	10	analysed	analyse	VBN
cord-001859-d62iuk72	119	11	by	by	IN
cord-001859-d62iuk72	119	12	Western	western	JJ
cord-001859-d62iuk72	119	13	blotting	blotting	NN
cord-001859-d62iuk72	119	14	.	.	.
cord-001859-d62iuk72	120	1	Nuclear	nuclear	JJ
cord-001859-d62iuk72	120	2	fractions	fraction	NNS
cord-001859-d62iuk72	120	3	were	be	VBD
cord-001859-d62iuk72	120	4	characterised	characterise	VBN
cord-001859-d62iuk72	120	5	by	by	IN
cord-001859-d62iuk72	120	6	enrichment	enrichment	NN
cord-001859-d62iuk72	120	7	of	of	IN
cord-001859-d62iuk72	120	8	lamin	lamin	NN
cord-001859-d62iuk72	120	9	B1	b1	NN
cord-001859-d62iuk72	120	10	and	and	CC
cord-001859-d62iuk72	120	11	absence	absence	NN
cord-001859-d62iuk72	120	12	of	of	IN
cord-001859-d62iuk72	120	13	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	120	14	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	120	15	,	,	,
cord-001859-d62iuk72	120	16	while	while	IN
cord-001859-d62iuk72	120	17	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	120	18	fractions	fraction	NNS
cord-001859-d62iuk72	120	19	showed	show	VBD
cord-001859-d62iuk72	120	20	the	the	DT
cord-001859-d62iuk72	120	21	inverse	inverse	NN
cord-001859-d62iuk72	120	22	profile	profile	NN
cord-001859-d62iuk72	120	23	.	.	.
cord-001859-d62iuk72	121	1	A	a	DT
cord-001859-d62iuk72	121	2	small	small	JJ
cord-001859-d62iuk72	121	3	decrease	decrease	NN
cord-001859-d62iuk72	121	4	in	in	IN
cord-001859-d62iuk72	121	5	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	121	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	121	7	which	which	WDT
cord-001859-d62iuk72	121	8	correlated	correlate	VBD
cord-001859-d62iuk72	121	9	with	with	IN
cord-001859-d62iuk72	121	10	a	a	DT
cord-001859-d62iuk72	121	11	small	small	JJ
cord-001859-d62iuk72	121	12	increase	increase	NN
cord-001859-d62iuk72	121	13	in	in	IN
cord-001859-d62iuk72	121	14	nuclear	nuclear	JJ
cord-001859-d62iuk72	121	15	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	121	16	was	be	VBD
cord-001859-d62iuk72	121	17	detected	detect	VBN
cord-001859-d62iuk72	121	18	in	in	IN
cord-001859-d62iuk72	121	19	reactivated	reactivate	VBN
cord-001859-d62iuk72	121	20	cells	cell	NNS
cord-001859-d62iuk72	121	21	,	,	,
cord-001859-d62iuk72	121	22	further	further	RB
cord-001859-d62iuk72	121	23	supporting	support	VBG
cord-001859-d62iuk72	121	24	that	that	IN
cord-001859-d62iuk72	121	25	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	121	26	was	be	VBD
cord-001859-d62iuk72	121	27	redistributed	redistribute	VBN
cord-001859-d62iuk72	121	28	from	from	IN
cord-001859-d62iuk72	121	29	the	the	DT
cord-001859-d62iuk72	121	30	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	121	31	to	to	IN
cord-001859-d62iuk72	121	32	the	the	DT
cord-001859-d62iuk72	121	33	nucleus	nucleus	NN
cord-001859-d62iuk72	121	34	.	.	.
cord-001859-d62iuk72	122	1	(	(	-LRB-
cord-001859-d62iuk72	122	2	C	C	NNP
cord-001859-d62iuk72	122	3	)	)	-RRB-
cord-001859-d62iuk72	122	4	TREx	TREx	NNPS
cord-001859-d62iuk72	122	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	122	6	cells	cell	NNS
cord-001859-d62iuk72	122	7	remained	remain	VBD
cord-001859-d62iuk72	122	8	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	122	9	(	(	-LRB-
cord-001859-d62iuk72	122	10	i	i	NN
cord-001859-d62iuk72	122	11	)	)	-RRB-
cord-001859-d62iuk72	122	12	or	or	CC
cord-001859-d62iuk72	122	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	122	14	for	for	IN
cord-001859-d62iuk72	122	15	24	24	CD
cord-001859-d62iuk72	122	16	h	h	NNP
cord-001859-d62iuk72	122	17	(	(	-LRB-
cord-001859-d62iuk72	122	18	iiiii	iiiii	NNP
cord-001859-d62iuk72	122	19	'	'	''
cord-001859-d62iuk72	122	20	)	)	-RRB-
cord-001859-d62iuk72	122	21	followed	follow	VBN
cord-001859-d62iuk72	122	22	by	by	IN
cord-001859-d62iuk72	122	23	triple	triple	JJ
cord-001859-d62iuk72	122	24	-	-	HYPH
cord-001859-d62iuk72	122	25	labelling	labelling	NN
cord-001859-d62iuk72	122	26	with	with	IN
cord-001859-d62iuk72	122	27	antibodies	antibody	NNS
cord-001859-d62iuk72	122	28	specific	specific	JJ
cord-001859-d62iuk72	122	29	for	for	IN
cord-001859-d62iuk72	122	30	RTA	RTA	NNP
cord-001859-d62iuk72	122	31	and	and	CC
cord-001859-d62iuk72	123	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	123	2	and	and	CC
cord-001859-d62iuk72	123	3	Click	click	VB
cord-001859-d62iuk72	123	4	-	-	:
cord-001859-d62iuk72	123	5	iT	it	PRP
cord-001859-d62iuk72	124	1	EdU	EdU	NNP
cord-001859-d62iuk72	124	2	Alexa	Alexa	NNP
cord-001859-d62iuk72	124	3	Fluor	Fluor	NNP
cord-001859-d62iuk72	124	4	647	647	CD
cord-001859-d62iuk72	125	1	,	,	,
cord-001859-d62iuk72	125	2	the	the	DT
cord-001859-d62iuk72	125	3	latter	latter	JJ
cord-001859-d62iuk72	125	4	allowed	allow	VBD
cord-001859-d62iuk72	125	5	visualization	visualization	NN
cord-001859-d62iuk72	125	6	of	of	IN
cord-001859-d62iuk72	125	7	newly	newly	RB
cord-001859-d62iuk72	125	8	synthesized	synthesize	VBN
cord-001859-d62iuk72	125	9	DNA	dna	NN
cord-001859-d62iuk72	125	10	.	.	.
cord-001859-d62iuk72	126	1	During	during	IN
cord-001859-d62iuk72	126	2	early	early	JJ
cord-001859-d62iuk72	126	3	reactivation	reactivation	NN
cord-001859-d62iuk72	126	4	,	,	,
cord-001859-d62iuk72	126	5	a	a	DT
cord-001859-d62iuk72	126	6	proportion	proportion	NN
cord-001859-d62iuk72	126	7	of	of	IN
cord-001859-d62iuk72	126	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	126	9	protein	protein	NN
cord-001859-d62iuk72	126	10	was	be	VBD
cord-001859-d62iuk72	126	11	adjacent	adjacent	JJ
cord-001859-d62iuk72	126	12	to	to	IN
cord-001859-d62iuk72	126	13	small	small	JJ
cord-001859-d62iuk72	126	14	viral	viral	JJ
cord-001859-d62iuk72	126	15	RTCs	rtc	NNS
cord-001859-d62iuk72	126	16	.	.	.
cord-001859-d62iuk72	127	1	Arrow	Arrow	NNP
cord-001859-d62iuk72	127	2	points	point	VBZ
cord-001859-d62iuk72	127	3	to	to	IN
cord-001859-d62iuk72	127	4	a	a	DT
cord-001859-d62iuk72	127	5	small	small	JJ
cord-001859-d62iuk72	127	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	127	7	RTC	RTC	NNP
cord-001859-d62iuk72	127	8	filled	fill	VBN
cord-001859-d62iuk72	127	9	with	with	IN
cord-001859-d62iuk72	127	10	viral	viral	JJ
cord-001859-d62iuk72	127	11	DNA	dna	NN
cord-001859-d62iuk72	127	12	(	(	-LRB-
cord-001859-d62iuk72	127	13	ii	ii	NN
cord-001859-d62iuk72	127	14	)	)	-RRB-
cord-001859-d62iuk72	127	15	.	.	.
cord-001859-d62iuk72	128	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	128	2	also	also	RB
cord-001859-d62iuk72	128	3	partially	partially	RB
cord-001859-d62iuk72	128	4	co	co	JJ
cord-001859-d62iuk72	128	5	-	-	VBN
cord-001859-d62iuk72	128	6	localised	localised	JJ
cord-001859-d62iuk72	128	7	with	with	IN
cord-001859-d62iuk72	128	8	viral	viral	JJ
cord-001859-d62iuk72	128	9	DNA	DNA	NNP
cord-001859-d62iuk72	128	10	(	(	-LRB-
cord-001859-d62iuk72	128	11	ii	ii	NN
cord-001859-d62iuk72	128	12	)	)	-RRB-
cord-001859-d62iuk72	128	13	and	and	CC
cord-001859-d62iuk72	128	14	RTA	RTA	NNP
cord-001859-d62iuk72	128	15	(	(	-LRB-
cord-001859-d62iuk72	128	16	ii	ii	NNP
cord-001859-d62iuk72	128	17	'	'	''
cord-001859-d62iuk72	128	18	)	)	-RRB-
cord-001859-d62iuk72	128	19	in	in	IN
cord-001859-d62iuk72	128	20	small	small	JJ
cord-001859-d62iuk72	128	21	RTCs	rtc	NNS
cord-001859-d62iuk72	128	22	.	.	.
cord-001859-d62iuk72	129	1	During	during	IN
cord-001859-d62iuk72	129	2	later	later	JJ
cord-001859-d62iuk72	129	3	reactivation	reactivation	NN
cord-001859-d62iuk72	129	4	times	time	NNS
cord-001859-d62iuk72	129	5	,	,	,
cord-001859-d62iuk72	129	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	129	7	completely	completely	RB
cord-001859-d62iuk72	129	8	moved	move	VBD
cord-001859-d62iuk72	129	9	within	within	IN
cord-001859-d62iuk72	129	10	fully	fully	RB
cord-001859-d62iuk72	129	11	-	-	HYPH
cord-001859-d62iuk72	129	12	developed	develop	VBN
cord-001859-d62iuk72	129	13	RTCs	rtc	NNS
cord-001859-d62iuk72	129	14	strongly	strongly	RB
cord-001859-d62iuk72	129	15	co	co	VBD
cord-001859-d62iuk72	129	16	-	-	JJ
cord-001859-d62iuk72	129	17	localising	localise	VBG
cord-001859-d62iuk72	129	18	with	with	IN
cord-001859-d62iuk72	129	19	viral	viral	JJ
cord-001859-d62iuk72	129	20	DNA	dna	NN
cord-001859-d62iuk72	129	21	(	(	-LRB-
cord-001859-d62iuk72	129	22	iii	iii	NN
cord-001859-d62iuk72	129	23	)	)	-RRB-
cord-001859-d62iuk72	129	24	and	and	CC
cord-001859-d62iuk72	129	25	RTA	RTA	NNP
cord-001859-d62iuk72	129	26	(	(	-LRB-
cord-001859-d62iuk72	129	27	iii	iii	NNP
cord-001859-d62iuk72	129	28	'	'	''
cord-001859-d62iuk72	129	29	)	)	-RRB-
cord-001859-d62iuk72	129	30	.	.	.
cord-001859-d62iuk72	130	1	rKSHV.219	rkshv.219	LS
cord-001859-d62iuk72	130	2	cells	cell	NNS
cord-001859-d62iuk72	130	3	,	,	,
cord-001859-d62iuk72	130	4	in	in	IN
cord-001859-d62iuk72	130	5	which	which	WDT
cord-001859-d62iuk72	130	6	the	the	DT
cord-001859-d62iuk72	130	7	presence	presence	NN
cord-001859-d62iuk72	130	8	of	of	IN
cord-001859-d62iuk72	130	9	the	the	DT
cord-001859-d62iuk72	130	10	recombinant	recombinant	JJ
cord-001859-d62iuk72	130	11	virus	virus	NN
cord-001859-d62iuk72	130	12	is	be	VBZ
cord-001859-d62iuk72	130	13	tracked	track	VBN
cord-001859-d62iuk72	130	14	by	by	IN
cord-001859-d62iuk72	130	15	expression	expression	NN
cord-001859-d62iuk72	130	16	of	of	IN
cord-001859-d62iuk72	130	17	the	the	DT
cord-001859-d62iuk72	130	18	green	green	JJ
cord-001859-d62iuk72	130	19	fluorescent	fluorescent	NN
cord-001859-d62iuk72	130	20	protein	protein	NN
cord-001859-d62iuk72	130	21	(	(	-LRB-
cord-001859-d62iuk72	130	22	GFP	GFP	NNP
cord-001859-d62iuk72	130	23	)	)	-RRB-
cord-001859-d62iuk72	130	24	from	from	IN
cord-001859-d62iuk72	130	25	the	the	DT
cord-001859-d62iuk72	130	26	EF-1alpha	ef-1alpha	NN
cord-001859-d62iuk72	130	27	promoter	promoter	NN
cord-001859-d62iuk72	130	28	and	and	CC
cord-001859-d62iuk72	130	29	lytic	lytic	JJ
cord-001859-d62iuk72	130	30	reactivation	reactivation	NN
cord-001859-d62iuk72	130	31	levels	level	NNS
cord-001859-d62iuk72	130	32	are	be	VBP
cord-001859-d62iuk72	130	33	monitored	monitor	VBN
cord-001859-d62iuk72	130	34	by	by	IN
cord-001859-d62iuk72	130	35	expression	expression	NN
cord-001859-d62iuk72	130	36	of	of	IN
cord-001859-d62iuk72	130	37	the	the	DT
cord-001859-d62iuk72	130	38	red	red	JJ
cord-001859-d62iuk72	130	39	fluorescent	fluorescent	NN
cord-001859-d62iuk72	130	40	protein	protein	NN
cord-001859-d62iuk72	130	41	(	(	-LRB-
cord-001859-d62iuk72	130	42	RFP	RFP	NNP
cord-001859-d62iuk72	130	43	)	)	-RRB-
cord-001859-d62iuk72	130	44	from	from	IN
cord-001859-d62iuk72	130	45	the	the	DT
cord-001859-d62iuk72	130	46	KSHV	KSHV	NNP
cord-001859-d62iuk72	130	47	lytic	lytic	JJ
cord-001859-d62iuk72	130	48	noncoding	noncoding	JJ
cord-001859-d62iuk72	130	49	polyadenylated	polyadenylated	JJ
cord-001859-d62iuk72	130	50	nuclear	nuclear	NNP
cord-001859-d62iuk72	130	51	(	(	-LRB-
cord-001859-d62iuk72	130	52	PAN	PAN	NNP
cord-001859-d62iuk72	130	53	)	)	-RRB-
cord-001859-d62iuk72	130	54	RNA	RNA	NNP
cord-001859-d62iuk72	130	55	promoter	promoter	NN
cord-001859-d62iuk72	130	56	.	.	.
cord-001859-d62iuk72	131	1	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	131	2	cells	cell	NNS
cord-001859-d62iuk72	131	3	displayed	display	VBD
cord-001859-d62iuk72	131	4	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	131	5	iHsp70	ihsp70	NN
cord-001859-d62iuk72	131	6	and	and	CC
cord-001859-d62iuk72	131	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	131	8	labelling	labelling	NN
cord-001859-d62iuk72	131	9	,	,	,
cord-001859-d62iuk72	131	10	whereas~40	whereas~40	NNP
cord-001859-d62iuk72	131	11	%	%	NN
cord-001859-d62iuk72	131	12	of	of	IN
cord-001859-d62iuk72	131	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	131	14	cells	cell	NNS
cord-001859-d62iuk72	131	15	(	(	-LRB-
cord-001859-d62iuk72	131	16	24	24	CD
cord-001859-d62iuk72	131	17	h	h	NN
cord-001859-d62iuk72	131	18	reactivation	reactivation	NN
cord-001859-d62iuk72	131	19	)	)	-RRB-
cord-001859-d62iuk72	131	20	revealed	reveal	VBD
cord-001859-d62iuk72	131	21	nuclear	nuclear	JJ
cord-001859-d62iuk72	131	22	iHsp70	ihsp70	NN
cord-001859-d62iuk72	131	23	and	and	CC
cord-001859-d62iuk72	131	24	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	131	25	accumulations	accumulation	NNS
cord-001859-d62iuk72	131	26	that	that	WDT
cord-001859-d62iuk72	131	27	appeared	appear	VBD
cord-001859-d62iuk72	131	28	to	to	TO
cord-001859-d62iuk72	131	29	assemble	assemble	VB
cord-001859-d62iuk72	131	30	within	within	IN
cord-001859-d62iuk72	131	31	small	small	JJ
cord-001859-d62iuk72	131	32	RTCs	rtc	NNS
cord-001859-d62iuk72	131	33	(	(	-LRB-
cord-001859-d62iuk72	131	34	S3A	s3a	CD
cord-001859-d62iuk72	131	35	Fig	Fig	NNP
cord-001859-d62iuk72	131	36	arrows	arrow	NNS
cord-001859-d62iuk72	131	37	and	and	CC
cord-001859-d62iuk72	131	38	S3B	S3B	VBD
cord-001859-d62iuk72	131	39	Fig	fig	NN
cord-001859-d62iuk72	131	40	arrows	arrow	NNS
cord-001859-d62iuk72	131	41	respectively	respectively	RB
cord-001859-d62iuk72	131	42	)	)	-RRB-
cord-001859-d62iuk72	131	43	.	.	.
cord-001859-d62iuk72	132	1	The	the	DT
cord-001859-d62iuk72	132	2	incomplete	incomplete	JJ
cord-001859-d62iuk72	132	3	redistribution	redistribution	NN
cord-001859-d62iuk72	132	4	of	of	IN
cord-001859-d62iuk72	132	5	iHsp70	ihsp70	NN
cord-001859-d62iuk72	132	6	and	and	CC
cord-001859-d62iuk72	132	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	132	8	foci	foci	NN
cord-001859-d62iuk72	132	9	into	into	IN
cord-001859-d62iuk72	132	10	RTCs	rtc	NNS
cord-001859-d62iuk72	132	11	was	be	VBD
cord-001859-d62iuk72	132	12	likely	likely	JJ
cord-001859-d62iuk72	132	13	due	due	IN
cord-001859-d62iuk72	132	14	to	to	IN
cord-001859-d62iuk72	132	15	a	a	DT
cord-001859-d62iuk72	132	16	more	more	RBR
cord-001859-d62iuk72	132	17	asynchronous	asynchronous	JJ
cord-001859-d62iuk72	132	18	progression	progression	NN
cord-001859-d62iuk72	132	19	through	through	IN
cord-001859-d62iuk72	132	20	the	the	DT
cord-001859-d62iuk72	132	21	lytic	lytic	JJ
cord-001859-d62iuk72	132	22	cycle	cycle	NN
cord-001859-d62iuk72	132	23	in	in	IN
cord-001859-d62iuk72	132	24	induced	induce	VBN
cord-001859-d62iuk72	132	25	cells	cell	NNS
cord-001859-d62iuk72	132	26	by	by	IN
cord-001859-d62iuk72	132	27	TPA	TPA	NNP
cord-001859-d62iuk72	132	28	and	and	CC
cord-001859-d62iuk72	132	29	sodium	sodium	NN
cord-001859-d62iuk72	132	30	n	n	NN
cord-001859-d62iuk72	132	31	-	-	HYPH
cord-001859-d62iuk72	132	32	butyrate	butyrate	NN
cord-001859-d62iuk72	132	33	than	than	IN
cord-001859-d62iuk72	132	34	in	in	IN
cord-001859-d62iuk72	132	35	doxycycline	doxycycline	NN
cord-001859-d62iuk72	132	36	-	-	HYPH
cord-001859-d62iuk72	132	37	induced	induce	VBN
cord-001859-d62iuk72	132	38	TREx	TREx	NNS
cord-001859-d62iuk72	132	39	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	132	40	cells	cell	NNS
cord-001859-d62iuk72	132	41	.	.	.
cord-001859-d62iuk72	133	1	Similarly	similarly	RB
cord-001859-d62iuk72	133	2	to	to	IN
cord-001859-d62iuk72	133	3	TREx	TREx	NNS
cord-001859-d62iuk72	133	4	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	133	5	cells	cell	NNS
cord-001859-d62iuk72	133	6	,	,	,
cord-001859-d62iuk72	133	7	Grp78	Grp78	NNP
cord-001859-d62iuk72	133	8	was	be	VBD
cord-001859-d62iuk72	133	9	not	not	RB
cord-001859-d62iuk72	133	10	redistributed	redistribute	VBN
cord-001859-d62iuk72	133	11	in	in	IN
cord-001859-d62iuk72	133	12	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	133	13	T	t	NN
cord-001859-d62iuk72	133	14	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	133	15	cells	cell	NNS
cord-001859-d62iuk72	133	16	,	,	,
cord-001859-d62iuk72	133	17	although	although	IN
cord-001859-d62iuk72	133	18	larger	large	JJR
cord-001859-d62iuk72	133	19	amounts	amount	NNS
cord-001859-d62iuk72	133	20	appeared	appear	VBD
cord-001859-d62iuk72	133	21	to	to	TO
cord-001859-d62iuk72	133	22	accumulate	accumulate	VB
cord-001859-d62iuk72	133	23	in	in	IN
cord-001859-d62iuk72	133	24	the	the	DT
cord-001859-d62iuk72	133	25	ER	er	NN
cord-001859-d62iuk72	133	26	of	of	IN
cord-001859-d62iuk72	133	27	reactivated	reactivate	VBN
cord-001859-d62iuk72	133	28	cells	cell	NNS
cord-001859-d62iuk72	133	29	(	(	-LRB-
cord-001859-d62iuk72	133	30	S3C	S3C	NNS
cord-001859-d62iuk72	133	31	Fig	Fig	NNP
cord-001859-d62iuk72	133	32	)	)	-RRB-
cord-001859-d62iuk72	133	33	,	,	,
cord-001859-d62iuk72	133	34	in	in	IN
cord-001859-d62iuk72	133	35	agreement	agreement	NN
cord-001859-d62iuk72	133	36	with	with	IN
cord-001859-d62iuk72	133	37	the	the	DT
cord-001859-d62iuk72	133	38	significantly	significantly	RB
cord-001859-d62iuk72	133	39	increased	increase	VBN
cord-001859-d62iuk72	133	40	amounts	amount	NNS
cord-001859-d62iuk72	133	41	of	of	IN
cord-001859-d62iuk72	133	42	Grp78	Grp78	NNP
cord-001859-d62iuk72	133	43	detected	detect	VBN
cord-001859-d62iuk72	133	44	in	in	IN
cord-001859-d62iuk72	133	45	the	the	DT
cord-001859-d62iuk72	133	46	NE	NE	NNP
cord-001859-d62iuk72	133	47	region	region	NN
cord-001859-d62iuk72	133	48	of	of	IN
cord-001859-d62iuk72	133	49	these	these	DT
cord-001859-d62iuk72	133	50	cells	cell	NNS
cord-001859-d62iuk72	133	51	(	(	-LRB-
cord-001859-d62iuk72	133	52	Table	table	NN
cord-001859-d62iuk72	133	53	1	1	CD
cord-001859-d62iuk72	133	54	)	)	-RRB-
cord-001859-d62iuk72	133	55	.	.	.
cord-001859-d62iuk72	134	1	These	these	DT
cord-001859-d62iuk72	134	2	results	result	NNS
cord-001859-d62iuk72	134	3	clearly	clearly	RB
cord-001859-d62iuk72	134	4	demonstrate	demonstrate	VBP
cord-001859-d62iuk72	134	5	that	that	IN
cord-001859-d62iuk72	134	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	134	7	specifically	specifically	RB
cord-001859-d62iuk72	134	8	redistributes	redistribute	VBZ
cord-001859-d62iuk72	134	9	the	the	DT
cord-001859-d62iuk72	134	10	molecular	molecular	JJ
cord-001859-d62iuk72	134	11	chaperones	chaperone	NNS
cord-001859-d62iuk72	134	12	,	,	,
cord-001859-d62iuk72	134	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	134	14	and	and	CC
cord-001859-d62iuk72	134	15	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	134	16	,	,	,
cord-001859-d62iuk72	134	17	from	from	IN
cord-001859-d62iuk72	134	18	the	the	DT
cord-001859-d62iuk72	134	19	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	134	20	to	to	IN
cord-001859-d62iuk72	134	21	the	the	DT
cord-001859-d62iuk72	134	22	nucleus	nucleus	NN
cord-001859-d62iuk72	134	23	,	,	,
cord-001859-d62iuk72	134	24	in	in	IN
cord-001859-d62iuk72	134	25	contrast	contrast	NN
cord-001859-d62iuk72	134	26	to	to	IN
cord-001859-d62iuk72	134	27	Grp78	Grp78	NNP
cord-001859-d62iuk72	134	28	,	,	,
cord-001859-d62iuk72	134	29	which	which	WDT
cord-001859-d62iuk72	134	30	coincides	coincide	VBZ
cord-001859-d62iuk72	134	31	with	with	IN
cord-001859-d62iuk72	134	32	the	the	DT
cord-001859-d62iuk72	134	33	initial	initial	JJ
cord-001859-d62iuk72	134	34	formation	formation	NN
cord-001859-d62iuk72	134	35	of	of	IN
cord-001859-d62iuk72	134	36	KSHV	KSHV	NNP
cord-001859-d62iuk72	134	37	RTCs	RTCs	NNP
cord-001859-d62iuk72	134	38	.	.	.
cord-001859-d62iuk72	135	1	Treatment	treatment	NN
cord-001859-d62iuk72	135	2	with	with	IN
cord-001859-d62iuk72	135	3	the	the	DT
cord-001859-d62iuk72	135	4	small	small	JJ
cord-001859-d62iuk72	135	5	molecule	molecule	NN
cord-001859-d62iuk72	135	6	inhibitor	inhibitor	NN
cord-001859-d62iuk72	135	7	VER-155008	ver-155008	NN
cord-001859-d62iuk72	135	8	abrogated	abrogate	VBD
cord-001859-d62iuk72	135	9	viral	viral	JJ
cord-001859-d62iuk72	135	10	protein	protein	NN
cord-001859-d62iuk72	135	11	synthesis	synthesis	NN
cord-001859-d62iuk72	135	12	at	at	IN
cord-001859-d62iuk72	135	13	non	non	JJ
cord-001859-d62iuk72	135	14	-	-	JJ
cord-001859-d62iuk72	135	15	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	135	16	concentrations	concentration	NNS
cord-001859-d62iuk72	135	17	Members	member	NNS
cord-001859-d62iuk72	135	18	of	of	IN
cord-001859-d62iuk72	135	19	the	the	DT
cord-001859-d62iuk72	135	20	HSP70	HSP70	NNP
cord-001859-d62iuk72	135	21	chaperone	chaperone	NN
cord-001859-d62iuk72	135	22	family	family	NN
cord-001859-d62iuk72	135	23	possess	possess	VBP
cord-001859-d62iuk72	135	24	an	an	DT
cord-001859-d62iuk72	135	25	N	n	CD
cord-001859-d62iuk72	135	26	-	-	HYPH
cord-001859-d62iuk72	135	27	terminal	terminal	NN
cord-001859-d62iuk72	135	28	nucleotide	nucleotide	JJ
cord-001859-d62iuk72	135	29	binding	bind	VBG
cord-001859-d62iuk72	135	30	domain	domain	NN
cord-001859-d62iuk72	135	31	with	with	IN
cord-001859-d62iuk72	135	32	ATPase	ATPase	NNP
cord-001859-d62iuk72	135	33	activity	activity	NN
cord-001859-d62iuk72	135	34	which	which	WDT
cord-001859-d62iuk72	135	35	is	be	VBZ
cord-001859-d62iuk72	135	36	essential	essential	JJ
cord-001859-d62iuk72	135	37	for	for	IN
cord-001859-d62iuk72	135	38	their	-PRON-	PRP$
cord-001859-d62iuk72	135	39	function	function	NN
cord-001859-d62iuk72	135	40	.	.	.
cord-001859-d62iuk72	136	1	To	to	TO
cord-001859-d62iuk72	136	2	examine	examine	VB
cord-001859-d62iuk72	136	3	the	the	DT
cord-001859-d62iuk72	136	4	implications	implication	NNS
cord-001859-d62iuk72	136	5	of	of	IN
cord-001859-d62iuk72	136	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	136	7	and	and	CC
cord-001859-d62iuk72	136	8	iHsp70	ihsp70	IN
cord-001859-d62iuk72	136	9	redistribution	redistribution	NN
cord-001859-d62iuk72	136	10	into	into	IN
cord-001859-d62iuk72	136	11	KSHV	KSHV	NNP
cord-001859-d62iuk72	136	12	RTCs	RTCs	NNP
cord-001859-d62iuk72	136	13	,	,	,
cord-001859-d62iuk72	136	14	a	a	DT
cord-001859-d62iuk72	136	15	small	small	JJ
cord-001859-d62iuk72	136	16	molecule	molecule	NN
cord-001859-d62iuk72	136	17	inhibitor	inhibitor	NN
cord-001859-d62iuk72	136	18	,	,	,
cord-001859-d62iuk72	136	19	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	136	20	,	,	,
cord-001859-d62iuk72	136	21	(	(	-LRB-
cord-001859-d62iuk72	136	22	a	a	DT
cord-001859-d62iuk72	136	23	dibenzyl-8-aminoadenosine	dibenzyl-8-aminoadenosine	JJ
cord-001859-d62iuk72	136	24	analog	analog	NN
cord-001859-d62iuk72	136	25	)	)	-RRB-
cord-001859-d62iuk72	136	26	was	be	VBD
cord-001859-d62iuk72	136	27	utilised	utilise	VBN
cord-001859-d62iuk72	136	28	.	.	.
cord-001859-d62iuk72	137	1	This	this	DT
cord-001859-d62iuk72	137	2	is	be	VBZ
cord-001859-d62iuk72	137	3	the	the	DT
cord-001859-d62iuk72	137	4	only	only	JJ
cord-001859-d62iuk72	137	5	inhibitor	inhibitor	NN
cord-001859-d62iuk72	137	6	that	that	WDT
cord-001859-d62iuk72	137	7	has	have	VBZ
cord-001859-d62iuk72	137	8	been	be	VBN
cord-001859-d62iuk72	137	9	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	137	10	to	to	TO
cord-001859-d62iuk72	137	11	specifically	specifically	RB
cord-001859-d62iuk72	137	12	target	target	VB
cord-001859-d62iuk72	137	13	the	the	DT
cord-001859-d62iuk72	137	14	highly	highly	RB
cord-001859-d62iuk72	137	15	homologous	homologous	JJ
cord-001859-d62iuk72	137	16	ATPase	ATPase	NNP
cord-001859-d62iuk72	137	17	pocket	pocket	NN
cord-001859-d62iuk72	137	18	present	present	JJ
cord-001859-d62iuk72	137	19	in	in	IN
cord-001859-d62iuk72	137	20	the	the	DT
cord-001859-d62iuk72	137	21	three	three	CD
cord-001859-d62iuk72	137	22	main	main	JJ
cord-001859-d62iuk72	137	23	human	human	NN
cord-001859-d62iuk72	137	24	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	137	25	isoforms	isoform	NNS
cord-001859-d62iuk72	137	26	[	[	-LRB-
cord-001859-d62iuk72	137	27	12	12	CD
cord-001859-d62iuk72	137	28	,	,	,
cord-001859-d62iuk72	137	29	13	13	CD
cord-001859-d62iuk72	137	30	,	,	,
cord-001859-d62iuk72	137	31	52	52	CD
cord-001859-d62iuk72	137	32	,	,	,
cord-001859-d62iuk72	137	33	53	53	CD
cord-001859-d62iuk72	137	34	]	]	-RRB-
cord-001859-d62iuk72	137	35	,	,	,
cord-001859-d62iuk72	137	36	which	which	WDT
cord-001859-d62iuk72	137	37	is	be	VBZ
cord-001859-d62iuk72	137	38	highly	highly	RB
cord-001859-d62iuk72	137	39	divergent	divergent	JJ
cord-001859-d62iuk72	137	40	structurally	structurally	RB
cord-001859-d62iuk72	137	41	from	from	IN
cord-001859-d62iuk72	137	42	the	the	DT
cord-001859-d62iuk72	137	43	ATPase	ATPase	NNP
cord-001859-d62iuk72	137	44	pocket	pocket	NN
cord-001859-d62iuk72	137	45	found	find	VBN
cord-001859-d62iuk72	137	46	in	in	IN
cord-001859-d62iuk72	137	47	chaperones	chaperone	NNS
cord-001859-d62iuk72	137	48	of	of	IN
cord-001859-d62iuk72	137	49	the	the	DT
cord-001859-d62iuk72	137	50	HSP90	HSP90	NNP
cord-001859-d62iuk72	137	51	family	family	NN
cord-001859-d62iuk72	137	52	[	[	-LRB-
cord-001859-d62iuk72	137	53	12	12	CD
cord-001859-d62iuk72	137	54	,	,	,
cord-001859-d62iuk72	137	55	54	54	CD
cord-001859-d62iuk72	137	56	]	]	-RRB-
cord-001859-d62iuk72	137	57	.	.	.
cord-001859-d62iuk72	138	1	As	as	IN
cord-001859-d62iuk72	138	2	such	such	JJ
cord-001859-d62iuk72	138	3	,	,	,
cord-001859-d62iuk72	138	4	VER-155008	ver-155008	NN
cord-001859-d62iuk72	138	5	functions	function	NNS
cord-001859-d62iuk72	138	6	as	as	IN
cord-001859-d62iuk72	138	7	an	an	DT
cord-001859-d62iuk72	138	8	ATP	ATP	NNP
cord-001859-d62iuk72	138	9	mimetic	mimetic	NN
cord-001859-d62iuk72	138	10	that	that	WDT
cord-001859-d62iuk72	138	11	specifically	specifically	RB
cord-001859-d62iuk72	138	12	inhibits	inhibit	VBZ
cord-001859-d62iuk72	138	13	the	the	DT
cord-001859-d62iuk72	138	14	ATPase	ATPase	NNP
cord-001859-d62iuk72	138	15	activity	activity	NN
cord-001859-d62iuk72	138	16	of	of	IN
cord-001859-d62iuk72	138	17	members	member	NNS
cord-001859-d62iuk72	138	18	of	of	IN
cord-001859-d62iuk72	138	19	the	the	DT
cord-001859-d62iuk72	138	20	HSP70	HSP70	NNP
cord-001859-d62iuk72	138	21	family	family	NN
cord-001859-d62iuk72	138	22	.	.	.
cord-001859-d62iuk72	139	1	Initially	initially	RB
cord-001859-d62iuk72	139	2	,	,	,
cord-001859-d62iuk72	139	3	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	139	4	of	of	IN
cord-001859-d62iuk72	139	5	this	this	DT
cord-001859-d62iuk72	139	6	compound	compound	NN
cord-001859-d62iuk72	139	7	was	be	VBD
cord-001859-d62iuk72	139	8	assessed	assess	VBN
cord-001859-d62iuk72	139	9	in	in	IN
cord-001859-d62iuk72	139	10	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	139	11	TREx	TREx	NNS
cord-001859-d62iuk72	139	12	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	139	13	cells	cell	NNS
cord-001859-d62iuk72	139	14	.	.	.
cord-001859-d62iuk72	140	1	Following	follow	VBG
cord-001859-d62iuk72	140	2	24	24	CD
cord-001859-d62iuk72	140	3	h	h	NN
cord-001859-d62iuk72	140	4	inhibitor	inhibitor	NN
cord-001859-d62iuk72	140	5	exposure	exposure	NN
cord-001859-d62iuk72	140	6	,	,	,
cord-001859-d62iuk72	140	7	using	use	VBG
cord-001859-d62iuk72	140	8	a	a	DT
cord-001859-d62iuk72	140	9	non	non	JJ
cord-001859-d62iuk72	140	10	-	-	JJ
cord-001859-d62iuk72	140	11	radioactive	radioactive	JJ
cord-001859-d62iuk72	140	12	MTS	MTS	NNP
cord-001859-d62iuk72	140	13	assay	assay	NN
cord-001859-d62iuk72	140	14	,	,	,
cord-001859-d62iuk72	140	15	which	which	WDT
cord-001859-d62iuk72	140	16	quantitatively	quantitatively	RB
cord-001859-d62iuk72	140	17	assesses	assess	VBZ
cord-001859-d62iuk72	140	18	cell	cell	NN
cord-001859-d62iuk72	140	19	proliferation	proliferation	NN
cord-001859-d62iuk72	140	20	,	,	,
cord-001859-d62iuk72	140	21	a	a	DT
cord-001859-d62iuk72	140	22	drastic	drastic	JJ
cord-001859-d62iuk72	140	23	reduction	reduction	NN
cord-001859-d62iuk72	140	24	in	in	IN
cord-001859-d62iuk72	140	25	cell	cell	NN
cord-001859-d62iuk72	140	26	metabolic	metabolic	JJ
cord-001859-d62iuk72	140	27	activity	activity	NN
cord-001859-d62iuk72	140	28	was	be	VBD
cord-001859-d62iuk72	140	29	seen	see	VBN
cord-001859-d62iuk72	140	30	for	for	IN
cord-001859-d62iuk72	140	31	inhibitor	inhibitor	NN
cord-001859-d62iuk72	140	32	concentrations	concentration	NNS
cord-001859-d62iuk72	140	33	higher	high	JJR
cord-001859-d62iuk72	140	34	than	than	IN
cord-001859-d62iuk72	140	35	6	6	CD
cord-001859-d62iuk72	140	36	μM	μm	NN
cord-001859-d62iuk72	140	37	(	(	-LRB-
cord-001859-d62iuk72	140	38	S4	S4	NNP
cord-001859-d62iuk72	140	39	Fig	Fig	NNP
cord-001859-d62iuk72	140	40	)	)	-RRB-
cord-001859-d62iuk72	140	41	,	,	,
cord-001859-d62iuk72	140	42	thus	thus	RB
cord-001859-d62iuk72	140	43	concentrations	concentration	NNS
cord-001859-d62iuk72	140	44	ranging	range	VBG
cord-001859-d62iuk72	140	45	from	from	IN
cord-001859-d62iuk72	140	46	1	1	CD
cord-001859-d62iuk72	140	47	to	to	IN
cord-001859-d62iuk72	140	48	4	4	CD
cord-001859-d62iuk72	140	49	μM	μM	NNS
cord-001859-d62iuk72	140	50	were	be	VBD
cord-001859-d62iuk72	140	51	used	use	VBN
cord-001859-d62iuk72	140	52	for	for	IN
cord-001859-d62iuk72	140	53	further	further	JJ
cord-001859-d62iuk72	140	54	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	140	55	characterization	characterization	NN
cord-001859-d62iuk72	140	56	(	(	-LRB-
cord-001859-d62iuk72	140	57	Fig	Fig	NNP
cord-001859-d62iuk72	140	58	3Ai	3ai	NN
cord-001859-d62iuk72	140	59	)	)	-RRB-
cord-001859-d62iuk72	140	60	.	.	.
cord-001859-d62iuk72	141	1	The	the	DT
cord-001859-d62iuk72	141	2	inhibitor	inhibitor	NN
cord-001859-d62iuk72	141	3	triggered	trigger	VBD
cord-001859-d62iuk72	141	4	apoptosis	apoptosis	NN
cord-001859-d62iuk72	141	5	in	in	IN
cord-001859-d62iuk72	141	6	a	a	DT
cord-001859-d62iuk72	141	7	dose	dose	NN
cord-001859-d62iuk72	141	8	-	-	HYPH
cord-001859-d62iuk72	141	9	dependent	dependent	JJ
cord-001859-d62iuk72	141	10	manner	manner	NN
cord-001859-d62iuk72	141	11	as	as	IN
cord-001859-d62iuk72	141	12	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	141	13	by	by	IN
cord-001859-d62iuk72	141	14	the	the	DT
cord-001859-d62iuk72	141	15	caspase	caspase	NN
cord-001859-d62iuk72	141	16	3-mediated	3-mediated	CD
cord-001859-d62iuk72	141	17	cleavage	cleavage	NN
cord-001859-d62iuk72	141	18	of	of	IN
cord-001859-d62iuk72	141	19	full	full	JJ
cord-001859-d62iuk72	141	20	length	length	NN
cord-001859-d62iuk72	141	21	poly	poly	JJ
cord-001859-d62iuk72	141	22	[	[	-LRB-
cord-001859-d62iuk72	141	23	ADP	ADP	NNP
cord-001859-d62iuk72	141	24	-	-	HYPH
cord-001859-d62iuk72	141	25	ribose	ribose	NN
cord-001859-d62iuk72	141	26	]	]	-RRB-
cord-001859-d62iuk72	141	27	polymerase	polymerase	NN
cord-001859-d62iuk72	141	28	(	(	-LRB-
cord-001859-d62iuk72	141	29	FL	FL	NNP
cord-001859-d62iuk72	141	30	-	-	HYPH
cord-001859-d62iuk72	141	31	PARP1	PARP1	NNP
cord-001859-d62iuk72	141	32	)	)	-RRB-
cord-001859-d62iuk72	141	33	protein	protein	NN
cord-001859-d62iuk72	141	34	into	into	IN
cord-001859-d62iuk72	141	35	cleaved	cleaved	JJ
cord-001859-d62iuk72	141	36	PARP1	PARP1	NNP
cord-001859-d62iuk72	142	1	(	(	-LRB-
cord-001859-d62iuk72	142	2	CL	CL	NNP
cord-001859-d62iuk72	142	3	-	-	HYPH
cord-001859-d62iuk72	142	4	PARP1	PARP1	NNP
cord-001859-d62iuk72	142	5	)	)	-RRB-
cord-001859-d62iuk72	143	1	(	(	-LRB-
cord-001859-d62iuk72	143	2	Fig	Fig	NNP
cord-001859-d62iuk72	143	3	3Aii	3Aii	NNP
cord-001859-d62iuk72	143	4	)	)	-RRB-
cord-001859-d62iuk72	143	5	.	.	.
cord-001859-d62iuk72	144	1	Small	small	JJ
cord-001859-d62iuk72	144	2	amounts	amount	NNS
cord-001859-d62iuk72	144	3	of	of	IN
cord-001859-d62iuk72	144	4	CL	CL	NNP
cord-001859-d62iuk72	144	5	-	-	HYPH
cord-001859-d62iuk72	144	6	PARP1	PARP1	NNP
cord-001859-d62iuk72	144	7	were	be	VBD
cord-001859-d62iuk72	144	8	seen	see	VBN
cord-001859-d62iuk72	144	9	at	at	IN
cord-001859-d62iuk72	144	10	1	1	CD
cord-001859-d62iuk72	144	11	μM	μm	CD
cord-001859-d62iuk72	145	1	and	and	CC
cord-001859-d62iuk72	145	2	2	2	CD
cord-001859-d62iuk72	145	3	μM	μm	CD
cord-001859-d62iuk72	145	4	with	with	IN
cord-001859-d62iuk72	145	5	a	a	DT
cord-001859-d62iuk72	145	6	significant	significant	JJ
cord-001859-d62iuk72	145	7	increase	increase	NN
cord-001859-d62iuk72	145	8	of	of	IN
cord-001859-d62iuk72	145	9	this	this	DT
cord-001859-d62iuk72	145	10	form	form	NN
cord-001859-d62iuk72	145	11	after	after	IN
cord-001859-d62iuk72	145	12	3	3	CD
cord-001859-d62iuk72	146	1	μM.	μM.	NNP
cord-001859-d62iuk72	146	2	These	these	DT
cord-001859-d62iuk72	146	3	results	result	NNS
cord-001859-d62iuk72	146	4	were	be	VBD
cord-001859-d62iuk72	146	5	confirmed	confirm	VBN
cord-001859-d62iuk72	146	6	with	with	IN
cord-001859-d62iuk72	146	7	ApoTox	ApoTox	NNP
cord-001859-d62iuk72	146	8	-	-	HYPH
cord-001859-d62iuk72	146	9	Glo	Glo	NNP
cord-001859-d62iuk72	146	10	Triplex	Triplex	NNP
cord-001859-d62iuk72	146	11	Assay	Assay	NNP
cord-001859-d62iuk72	146	12	by	by	IN
cord-001859-d62iuk72	146	13	quantitatively	quantitatively	RB
cord-001859-d62iuk72	146	14	measuring	measure	VBG
cord-001859-d62iuk72	146	15	viability	viability	NN
cord-001859-d62iuk72	146	16	,	,	,
cord-001859-d62iuk72	146	17	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	146	18	and	and	CC
cord-001859-d62iuk72	146	19	activation	activation	NN
cord-001859-d62iuk72	146	20	of	of	IN
cord-001859-d62iuk72	146	21	effector	effector	NN
cord-001859-d62iuk72	146	22	caspases-3/7	caspases-3/7	NNP
cord-001859-d62iuk72	146	23	in	in	IN
cord-001859-d62iuk72	146	24	the	the	DT
cord-001859-d62iuk72	146	25	same	same	JJ
cord-001859-d62iuk72	146	26	sample	sample	NN
cord-001859-d62iuk72	146	27	well	well	RB
cord-001859-d62iuk72	146	28	after	after	IN
cord-001859-d62iuk72	146	29	24	24	CD
cord-001859-d62iuk72	146	30	h	h	NN
cord-001859-d62iuk72	146	31	inhibitor	inhibitor	NN
cord-001859-d62iuk72	146	32	treatment	treatment	NN
cord-001859-d62iuk72	146	33	.	.	.
cord-001859-d62iuk72	147	1	A	a	DT
cord-001859-d62iuk72	147	2	dose	dose	NN
cord-001859-d62iuk72	147	3	-	-	HYPH
cord-001859-d62iuk72	147	4	dependent	dependent	JJ
cord-001859-d62iuk72	147	5	decrease	decrease	NN
cord-001859-d62iuk72	147	6	in	in	IN
cord-001859-d62iuk72	147	7	viability	viability	NN
cord-001859-d62iuk72	147	8	was	be	VBD
cord-001859-d62iuk72	147	9	evident	evident	JJ
cord-001859-d62iuk72	147	10	from	from	IN
cord-001859-d62iuk72	147	11	2	2	CD
cord-001859-d62iuk72	147	12	μM	μm	NN
cord-001859-d62iuk72	147	13	to	to	IN
cord-001859-d62iuk72	147	14	50	50	CD
cord-001859-d62iuk72	147	15	μM	μm	NN
cord-001859-d62iuk72	147	16	while	while	IN
cord-001859-d62iuk72	147	17	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	147	18	and	and	CC
cord-001859-d62iuk72	147	19	activation	activation	NN
cord-001859-d62iuk72	147	20	of	of	IN
cord-001859-d62iuk72	147	21	caspases-3/7	caspases-3/7	NNP
cord-001859-d62iuk72	147	22	were	be	VBD
cord-001859-d62iuk72	147	23	only	only	RB
cord-001859-d62iuk72	147	24	considerably	considerably	RB
cord-001859-d62iuk72	147	25	increased	increase	VBN
cord-001859-d62iuk72	147	26	at	at	IN
cord-001859-d62iuk72	147	27	concentrations	concentration	NNS
cord-001859-d62iuk72	147	28	higher	high	JJR
cord-001859-d62iuk72	147	29	than	than	IN
cord-001859-d62iuk72	147	30	3	3	CD
cord-001859-d62iuk72	148	1	μM	μM	NNP
cord-001859-d62iuk72	149	1	(	(	-LRB-
cord-001859-d62iuk72	149	2	Fig	Fig	NNP
cord-001859-d62iuk72	149	3	3B	3b	CD
cord-001859-d62iuk72	149	4	)	)	-RRB-
cord-001859-d62iuk72	149	5	.	.	.
cord-001859-d62iuk72	150	1	Next	next	RB
cord-001859-d62iuk72	150	2	,	,	,
cord-001859-d62iuk72	150	3	TREx	TREx	NNS
cord-001859-d62iuk72	150	4	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	150	5	cells	cell	NNS
cord-001859-d62iuk72	150	6	were	be	VBD
cord-001859-d62iuk72	150	7	reactivated	reactivate	VBN
cord-001859-d62iuk72	150	8	for	for	IN
cord-001859-d62iuk72	150	9	24	24	CD
cord-001859-d62iuk72	150	10	h	h	NN
cord-001859-d62iuk72	150	11	in	in	IN
cord-001859-d62iuk72	150	12	the	the	DT
cord-001859-d62iuk72	150	13	presence	presence	NN
cord-001859-d62iuk72	150	14	of	of	IN
cord-001859-d62iuk72	150	15	drug	drug	NN
cord-001859-d62iuk72	150	16	vehicle	vehicle	NN
cord-001859-d62iuk72	150	17	DMSO	DMSO	NNP
cord-001859-d62iuk72	150	18	(	(	-LRB-
cord-001859-d62iuk72	150	19	0.1	0.1	CD
cord-001859-d62iuk72	150	20	%	%	NN
cord-001859-d62iuk72	150	21	)	)	-RRB-
cord-001859-d62iuk72	150	22	or	or	CC
cord-001859-d62iuk72	150	23	a	a	DT
cord-001859-d62iuk72	150	24	range	range	NN
cord-001859-d62iuk72	150	25	of	of	IN
cord-001859-d62iuk72	150	26	increasing	increase	VBG
cord-001859-d62iuk72	150	27	inhibitor	inhibitor	NN
cord-001859-d62iuk72	150	28	concentrations	concentration	NNS
cord-001859-d62iuk72	150	29	.	.	.
cord-001859-d62iuk72	151	1	Cells	cell	NNS
cord-001859-d62iuk72	151	2	treated	treat	VBN
cord-001859-d62iuk72	151	3	with	with	IN
cord-001859-d62iuk72	151	4	the	the	DT
cord-001859-d62iuk72	151	5	inhibitor	inhibitor	NN
cord-001859-d62iuk72	151	6	at	at	IN
cord-001859-d62iuk72	151	7	non	non	JJ
cord-001859-d62iuk72	151	8	-	-	JJ
cord-001859-d62iuk72	151	9	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	151	10	concentrations	concentration	NNS
cord-001859-d62iuk72	151	11	(	(	-LRB-
cord-001859-d62iuk72	151	12	1	1	CD
cord-001859-d62iuk72	151	13	to	to	IN
cord-001859-d62iuk72	151	14	2.5	2.5	CD
cord-001859-d62iuk72	151	15	μM	μM	NNS
cord-001859-d62iuk72	151	16	)	)	-RRB-
cord-001859-d62iuk72	151	17	revealed	reveal	VBD
cord-001859-d62iuk72	151	18	a	a	DT
cord-001859-d62iuk72	151	19	drastic	drastic	JJ
cord-001859-d62iuk72	151	20	reduction	reduction	NN
cord-001859-d62iuk72	151	21	in	in	IN
cord-001859-d62iuk72	151	22	the	the	DT
cord-001859-d62iuk72	151	23	levels	level	NNS
cord-001859-d62iuk72	151	24	of	of	IN
cord-001859-d62iuk72	151	25	early	early	JJ
cord-001859-d62iuk72	151	26	ORF57	ORF57	NNP
cord-001859-d62iuk72	151	27	and	and	CC
cord-001859-d62iuk72	151	28	late	late	JJ
cord-001859-d62iuk72	151	29	minor	minor	JJ
cord-001859-d62iuk72	151	30	capsid	capsid	NN
cord-001859-d62iuk72	151	31	(	(	-LRB-
cord-001859-d62iuk72	151	32	mCapsid	mCapsid	NNP
cord-001859-d62iuk72	151	33	)	)	-RRB-
cord-001859-d62iuk72	151	34	proteins	protein	NNS
cord-001859-d62iuk72	151	35	.	.	.
cord-001859-d62iuk72	152	1	A	a	DT
cord-001859-d62iuk72	152	2	moderate	moderate	JJ
cord-001859-d62iuk72	152	3	reduction	reduction	NN
cord-001859-d62iuk72	152	4	in	in	IN
cord-001859-d62iuk72	152	5	the	the	DT
cord-001859-d62iuk72	152	6	immediateearly	immediateearly	NN
cord-001859-d62iuk72	153	1	RTA	RTA	NNP
cord-001859-d62iuk72	153	2	protein	protein	NN
cord-001859-d62iuk72	153	3	was	be	VBD
cord-001859-d62iuk72	153	4	also	also	RB
cord-001859-d62iuk72	153	5	seen	see	VBN
cord-001859-d62iuk72	153	6	(	(	-LRB-
cord-001859-d62iuk72	153	7	Fig	Fig	NNP
cord-001859-d62iuk72	153	8	3C	3c	NN
cord-001859-d62iuk72	153	9	)	)	-RRB-
cord-001859-d62iuk72	153	10	.	.	.
cord-001859-d62iuk72	154	1	Of	of	IN
cord-001859-d62iuk72	154	2	note	note	NN
cord-001859-d62iuk72	154	3	,	,	,
cord-001859-d62iuk72	154	4	when	when	WRB
cord-001859-d62iuk72	154	5	detecting	detect	VBG
cord-001859-d62iuk72	154	6	the	the	DT
cord-001859-d62iuk72	154	7	fusion	fusion	NN
cord-001859-d62iuk72	154	8	protein	protein	NN
cord-001859-d62iuk72	154	9	RTA	RTA	NNP
cord-001859-d62iuk72	154	10	-	-	HYPH
cord-001859-d62iuk72	154	11	Myc	Myc	NNP
cord-001859-d62iuk72	154	12	,	,	,
cord-001859-d62iuk72	154	13	which	which	WDT
cord-001859-d62iuk72	154	14	expression	expression	NN
cord-001859-d62iuk72	154	15	is	be	VBZ
cord-001859-d62iuk72	154	16	not	not	RB
cord-001859-d62iuk72	154	17	from	from	IN
cord-001859-d62iuk72	154	18	the	the	DT
cord-001859-d62iuk72	154	19	KSHV	KSHV	NNP
cord-001859-d62iuk72	154	20	genome	genome	NN
cord-001859-d62iuk72	154	21	,	,	,
cord-001859-d62iuk72	154	22	with	with	IN
cord-001859-d62iuk72	154	23	anti	anti	JJ
cord-001859-d62iuk72	154	24	-	-	JJ
cord-001859-d62iuk72	154	25	Myc	myc	JJ
cord-001859-d62iuk72	154	26	antibody	antibody	NN
cord-001859-d62iuk72	154	27	,	,	,
cord-001859-d62iuk72	154	28	the	the	DT
cord-001859-d62iuk72	154	29	decrease	decrease	NN
cord-001859-d62iuk72	154	30	in	in	IN
cord-001859-d62iuk72	154	31	RTA	RTA	NNP
cord-001859-d62iuk72	154	32	-	-	HYPH
cord-001859-d62iuk72	154	33	Myc	Myc	NNP
cord-001859-d62iuk72	154	34	was	be	VBD
cord-001859-d62iuk72	154	35	not	not	RB
cord-001859-d62iuk72	154	36	as	as	RB
cord-001859-d62iuk72	154	37	dramatic	dramatic	JJ
cord-001859-d62iuk72	154	38	as	as	IN
cord-001859-d62iuk72	154	39	that	that	DT
cord-001859-d62iuk72	154	40	seen	see	VBN
cord-001859-d62iuk72	154	41	for	for	IN
cord-001859-d62iuk72	154	42	viral	viral	JJ
cord-001859-d62iuk72	154	43	RTA	RTA	NNP
cord-001859-d62iuk72	154	44	,	,	,
cord-001859-d62iuk72	154	45	suggesting	suggest	VBG
cord-001859-d62iuk72	154	46	that	that	IN
cord-001859-d62iuk72	154	47	the	the	DT
cord-001859-d62iuk72	154	48	decrease	decrease	NN
cord-001859-d62iuk72	154	49	in	in	IN
cord-001859-d62iuk72	154	50	viral	viral	JJ
cord-001859-d62iuk72	154	51	proteins	protein	NNS
cord-001859-d62iuk72	154	52	was	be	VBD
cord-001859-d62iuk72	154	53	not	not	RB
cord-001859-d62iuk72	154	54	due	due	JJ
cord-001859-d62iuk72	154	55	to	to	IN
cord-001859-d62iuk72	154	56	a	a	DT
cord-001859-d62iuk72	154	57	general	general	JJ
cord-001859-d62iuk72	154	58	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	154	59	effect	effect	NN
cord-001859-d62iuk72	154	60	of	of	IN
cord-001859-d62iuk72	154	61	the	the	DT
cord-001859-d62iuk72	154	62	inhibitor	inhibitor	NN
cord-001859-d62iuk72	154	63	on	on	IN
cord-001859-d62iuk72	154	64	the	the	DT
cord-001859-d62iuk72	154	65	cells	cell	NNS
cord-001859-d62iuk72	154	66	,	,	,
cord-001859-d62iuk72	154	67	and	and	CC
cord-001859-d62iuk72	154	68	that	that	IN
cord-001859-d62iuk72	154	69	viral	viral	JJ
cord-001859-d62iuk72	154	70	,	,	,
cord-001859-d62iuk72	154	71	but	but	CC
cord-001859-d62iuk72	154	72	not	not	RB
cord-001859-d62iuk72	154	73	cellular	cellular	JJ
cord-001859-d62iuk72	154	74	proteins	protein	NNS
cord-001859-d62iuk72	154	75	were	be	VBD
cord-001859-d62iuk72	154	76	specifically	specifically	RB
cord-001859-d62iuk72	154	77	affected	affect	VBN
cord-001859-d62iuk72	154	78	.	.	.
cord-001859-d62iuk72	155	1	As	as	IN
cord-001859-d62iuk72	155	2	an	an	DT
cord-001859-d62iuk72	155	3	additional	additional	JJ
cord-001859-d62iuk72	155	4	cellular	cellular	JJ
cord-001859-d62iuk72	155	5	control	control	NN
cord-001859-d62iuk72	155	6	,	,	,
cord-001859-d62iuk72	155	7	protein	protein	NN
cord-001859-d62iuk72	155	8	levels	level	NNS
cord-001859-d62iuk72	155	9	of	of	IN
cord-001859-d62iuk72	155	10	the	the	DT
cord-001859-d62iuk72	155	11	large	large	JJ
cord-001859-d62iuk72	155	12	subunit	subunit	NN
cord-001859-d62iuk72	155	13	of	of	IN
cord-001859-d62iuk72	155	14	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	155	15	,	,	,
cord-001859-d62iuk72	155	16	which	which	WDT
cord-001859-d62iuk72	155	17	has	have	VBZ
cord-001859-d62iuk72	155	18	a	a	DT
cord-001859-d62iuk72	155	19	half	half	JJ
cord-001859-d62iuk72	155	20	-	-	HYPH
cord-001859-d62iuk72	155	21	life	life	NN
cord-001859-d62iuk72	155	22	of	of	IN
cord-001859-d62iuk72	155	23	12	12	CD
cord-001859-d62iuk72	155	24	-	-	SYM
cord-001859-d62iuk72	155	25	16	16	CD
cord-001859-d62iuk72	155	26	h	h	NN
cord-001859-d62iuk72	155	27	[	[	-LRB-
cord-001859-d62iuk72	155	28	55	55	CD
cord-001859-d62iuk72	155	29	]	]	-RRB-
cord-001859-d62iuk72	155	30	,	,	,
cord-001859-d62iuk72	155	31	was	be	VBD
cord-001859-d62iuk72	155	32	assessed	assess	VBN
cord-001859-d62iuk72	155	33	with	with	IN
cord-001859-d62iuk72	155	34	antibodies	antibody	NNS
cord-001859-d62iuk72	155	35	specific	specific	JJ
cord-001859-d62iuk72	155	36	for	for	IN
cord-001859-d62iuk72	155	37	the	the	DT
cord-001859-d62iuk72	155	38	different	different	JJ
cord-001859-d62iuk72	155	39	phosphorylated	phosphorylated	JJ
cord-001859-d62iuk72	155	40	forms	form	NNS
cord-001859-d62iuk72	155	41	of	of	IN
cord-001859-d62iuk72	155	42	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	155	43	.	.	.
cord-001859-d62iuk72	156	1	Protein	protein	NN
cord-001859-d62iuk72	156	2	levels	level	NNS
cord-001859-d62iuk72	156	3	of	of	IN
cord-001859-d62iuk72	156	4	these	these	DT
cord-001859-d62iuk72	156	5	forms	form	NNS
cord-001859-d62iuk72	156	6	were	be	VBD
cord-001859-d62iuk72	156	7	not	not	RB
cord-001859-d62iuk72	156	8	significantly	significantly	RB
cord-001859-d62iuk72	156	9	changed	change	VBN
cord-001859-d62iuk72	156	10	in	in	IN
cord-001859-d62iuk72	156	11	the	the	DT
cord-001859-d62iuk72	156	12	presence	presence	NN
cord-001859-d62iuk72	156	13	of	of	IN
cord-001859-d62iuk72	156	14	the	the	DT
cord-001859-d62iuk72	156	15	inhibitor	inhibitor	NN
cord-001859-d62iuk72	156	16	,	,	,
cord-001859-d62iuk72	156	17	nor	nor	CC
cord-001859-d62iuk72	156	18	were	be	VBD
cord-001859-d62iuk72	156	19	those	those	DT
cord-001859-d62iuk72	156	20	of	of	IN
cord-001859-d62iuk72	156	21	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	156	22	or	or	CC
cord-001859-d62iuk72	156	23	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	156	24	proteins	protein	NNS
cord-001859-d62iuk72	156	25	.	.	.
cord-001859-d62iuk72	157	1	Importantly	importantly	RB
cord-001859-d62iuk72	157	2	,	,	,
cord-001859-d62iuk72	157	3	in	in	IN
cord-001859-d62iuk72	157	4	the	the	DT
cord-001859-d62iuk72	157	5	presence	presence	NN
cord-001859-d62iuk72	157	6	of	of	IN
cord-001859-d62iuk72	157	7	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	157	8	,	,	,
cord-001859-d62iuk72	157	9	iHsp70	ihsp70	NN
cord-001859-d62iuk72	157	10	levels	level	NNS
cord-001859-d62iuk72	157	11	were	be	VBD
cord-001859-d62iuk72	157	12	not	not	RB
cord-001859-d62iuk72	157	13	upregulated	upregulate	VBN
cord-001859-d62iuk72	157	14	.	.	.
cord-001859-d62iuk72	158	1	iHsp70	iHsp70	.
cord-001859-d62iuk72	159	1	upregulation	upregulation	NN
cord-001859-d62iuk72	159	2	is	be	VBZ
cord-001859-d62iuk72	159	3	a	a	DT
cord-001859-d62iuk72	159	4	universal	universal	JJ
cord-001859-d62iuk72	159	5	hallmark	hallmark	NN
cord-001859-d62iuk72	159	6	of	of	IN
cord-001859-d62iuk72	159	7	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	159	8	inhibition	inhibition	NN
cord-001859-d62iuk72	159	9	not	not	RB
cord-001859-d62iuk72	159	10	only	only	RB
cord-001859-d62iuk72	159	11	in	in	IN
cord-001859-d62iuk72	159	12	vitro	vitro	FW
cord-001859-d62iuk72	159	13	[	[	-LRB-
cord-001859-d62iuk72	159	14	56	56	CD
cord-001859-d62iuk72	159	15	]	]	-RRB-
cord-001859-d62iuk72	159	16	but	but	CC
cord-001859-d62iuk72	159	17	also	also	RB
cord-001859-d62iuk72	159	18	in	in	IN
cord-001859-d62iuk72	159	19	clinical	clinical	JJ
cord-001859-d62iuk72	159	20	trials	trial	NNS
cord-001859-d62iuk72	159	21	[	[	-LRB-
cord-001859-d62iuk72	159	22	57	57	CD
cord-001859-d62iuk72	159	23	]	]	-RRB-
cord-001859-d62iuk72	159	24	,	,	,
cord-001859-d62iuk72	159	25	pointing	point	VBG
cord-001859-d62iuk72	159	26	to	to	IN
cord-001859-d62iuk72	159	27	selectivity	selectivity	NN
cord-001859-d62iuk72	159	28	for	for	IN
cord-001859-d62iuk72	159	29	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	159	30	isoforms	isoform	NNS
cord-001859-d62iuk72	159	31	by	by	IN
cord-001859-d62iuk72	159	32	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	159	33	.	.	.
cord-001859-d62iuk72	160	1	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	160	2	and	and	CC
cord-001859-d62iuk72	160	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	161	1	chaperone	chaperone	NN
cord-001859-d62iuk72	161	2	machineries	machinery	NNS
cord-001859-d62iuk72	161	3	have	have	VBP
cord-001859-d62iuk72	161	4	been	be	VBN
cord-001859-d62iuk72	161	5	reported	report	VBN
cord-001859-d62iuk72	161	6	to	to	TO
cord-001859-d62iuk72	161	7	be	be	VB
cord-001859-d62iuk72	161	8	crucial	crucial	JJ
cord-001859-d62iuk72	161	9	for	for	IN
cord-001859-d62iuk72	161	10	the	the	DT
cord-001859-d62iuk72	161	11	stability	stability	NN
cord-001859-d62iuk72	161	12	and/or	and/or	CC
cord-001859-d62iuk72	161	13	maturation	maturation	NN
cord-001859-d62iuk72	161	14	of	of	IN
cord-001859-d62iuk72	161	15	multiple	multiple	JJ
cord-001859-d62iuk72	161	16	viral	viral	JJ
cord-001859-d62iuk72	161	17	proteins	protein	NNS
cord-001859-d62iuk72	161	18	[	[	-LRB-
cord-001859-d62iuk72	161	19	7	7	CD
cord-001859-d62iuk72	161	20	,	,	,
cord-001859-d62iuk72	161	21	41	41	CD
cord-001859-d62iuk72	161	22	,	,	,
cord-001859-d62iuk72	162	1	[	[	-LRB-
cord-001859-d62iuk72	162	2	58	58	CD
cord-001859-d62iuk72	162	3	]	]	-RRB-
cord-001859-d62iuk72	162	4	[	[	-LRB-
cord-001859-d62iuk72	162	5	59	59	CD
cord-001859-d62iuk72	162	6	]	]	-RRB-
cord-001859-d62iuk72	162	7	[	[	-LRB-
cord-001859-d62iuk72	162	8	60	60	CD
cord-001859-d62iuk72	162	9	]	]	-RRB-
cord-001859-d62iuk72	162	10	[	[	-LRB-
cord-001859-d62iuk72	162	11	61	61	CD
cord-001859-d62iuk72	162	12	]	]	-RRB-
cord-001859-d62iuk72	162	13	[	[	-LRB-
cord-001859-d62iuk72	162	14	62	62	CD
cord-001859-d62iuk72	162	15	]	]	-RRB-
cord-001859-d62iuk72	162	16	.	.	.
cord-001859-d62iuk72	163	1	Therefore	therefore	RB
cord-001859-d62iuk72	163	2	to	to	TO
cord-001859-d62iuk72	163	3	ascertain	ascertain	VB
cord-001859-d62iuk72	163	4	whether	whether	IN
cord-001859-d62iuk72	163	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	163	6	isoforms	isoform	NNS
cord-001859-d62iuk72	163	7	could	could	MD
cord-001859-d62iuk72	163	8	stabilise	stabilise	VB
cord-001859-d62iuk72	163	9	the	the	DT
cord-001859-d62iuk72	163	10	essential	essential	JJ
cord-001859-d62iuk72	163	11	KSHV	KSHV	NNP
cord-001859-d62iuk72	163	12	lytic	lytic	JJ
cord-001859-d62iuk72	163	13	proteins	protein	NNS
cord-001859-d62iuk72	163	14	RTA	RTA	NNP
cord-001859-d62iuk72	163	15	and	and	CC
cord-001859-d62iuk72	163	16	ORF57	ORF57	NNP
cord-001859-d62iuk72	163	17	,	,	,
cord-001859-d62iuk72	163	18	TREx	TREx	NNS
cord-001859-d62iuk72	163	19	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	163	20	cells	cell	NNS
cord-001859-d62iuk72	163	21	were	be	VBD
cord-001859-d62iuk72	163	22	reactivated	reactivate	VBN
cord-001859-d62iuk72	163	23	for	for	IN
cord-001859-d62iuk72	163	24	24	24	CD
cord-001859-d62iuk72	163	25	h	h	NN
cord-001859-d62iuk72	163	26	to	to	TO
cord-001859-d62iuk72	163	27	allow	allow	VB
cord-001859-d62iuk72	163	28	sufficient	sufficient	JJ
cord-001859-d62iuk72	163	29	viral	viral	JJ
cord-001859-d62iuk72	163	30	protein	protein	NN
cord-001859-d62iuk72	163	31	expression	expression	NN
cord-001859-d62iuk72	163	32	followed	follow	VBN
cord-001859-d62iuk72	163	33	by	by	IN
cord-001859-d62iuk72	163	34	addition	addition	NN
cord-001859-d62iuk72	163	35	of	of	IN
cord-001859-d62iuk72	163	36	DMSO	DMSO	NNP
cord-001859-d62iuk72	163	37	control	control	NN
cord-001859-d62iuk72	163	38	or	or	CC
cord-001859-d62iuk72	163	39	VER-155008	ver-155008	NN
cord-001859-d62iuk72	163	40	in	in	IN
cord-001859-d62iuk72	163	41	conjunction	conjunction	NN
cord-001859-d62iuk72	163	42	with	with	IN
cord-001859-d62iuk72	163	43	cycloheximide	cycloheximide	NN
cord-001859-d62iuk72	163	44	(	(	-LRB-
cord-001859-d62iuk72	163	45	CHX	CHX	NNP
cord-001859-d62iuk72	163	46	)	)	-RRB-
cord-001859-d62iuk72	163	47	at	at	IN
cord-001859-d62iuk72	163	48	50	50	CD
cord-001859-d62iuk72	163	49	μg	μg	NNS
cord-001859-d62iuk72	163	50	/	/	SYM
cord-001859-d62iuk72	163	51	ml	ml	NN
cord-001859-d62iuk72	163	52	to	to	TO
cord-001859-d62iuk72	163	53	block	block	VB
cord-001859-d62iuk72	163	54	de	de	NNP
cord-001859-d62iuk72	163	55	novo	novo	NNP
cord-001859-d62iuk72	163	56	protein	protein	NNP
cord-001859-d62iuk72	163	57	synthesis	synthesis	NN
cord-001859-d62iuk72	163	58	.	.	.
cord-001859-d62iuk72	164	1	Protein	protein	NN
cord-001859-d62iuk72	164	2	lysates	lysate	NNS
cord-001859-d62iuk72	164	3	were	be	VBD
cord-001859-d62iuk72	164	4	then	then	RB
cord-001859-d62iuk72	164	5	collected	collect	VBN
cord-001859-d62iuk72	164	6	at	at	IN
cord-001859-d62iuk72	164	7	different	different	JJ
cord-001859-d62iuk72	164	8	times	time	NNS
cord-001859-d62iuk72	164	9	after	after	IN
cord-001859-d62iuk72	164	10	addition	addition	NN
cord-001859-d62iuk72	164	11	of	of	IN
cord-001859-d62iuk72	164	12	CHX	CHX	NNP
cord-001859-d62iuk72	164	13	.	.	.
cord-001859-d62iuk72	165	1	The	the	DT
cord-001859-d62iuk72	165	2	half	half	JJ
cord-001859-d62iuk72	165	3	-	-	HYPH
cord-001859-d62iuk72	165	4	life	life	NN
cord-001859-d62iuk72	165	5	of	of	IN
cord-001859-d62iuk72	165	6	RTA	RTA	NNP
cord-001859-d62iuk72	165	7	and	and	CC
cord-001859-d62iuk72	165	8	ORF57	ORF57	NNP
cord-001859-d62iuk72	165	9	proteins	protein	NNS
cord-001859-d62iuk72	165	10	from	from	IN
cord-001859-d62iuk72	165	11	inhibitor	inhibitor	NN
cord-001859-d62iuk72	165	12	-	-	HYPH
cord-001859-d62iuk72	165	13	treated	treat	VBN
cord-001859-d62iuk72	165	14	cells	cell	NNS
cord-001859-d62iuk72	165	15	were	be	VBD
cord-001859-d62iuk72	165	16	not	not	RB
cord-001859-d62iuk72	165	17	altered	alter	VBN
cord-001859-d62iuk72	165	18	compared	compare	VBN
cord-001859-d62iuk72	165	19	with	with	IN
cord-001859-d62iuk72	165	20	DMSO	DMSO	NNP
cord-001859-d62iuk72	165	21	-	-	HYPH
cord-001859-d62iuk72	165	22	treated	treat	VBN
cord-001859-d62iuk72	165	23	cells	cell	NNS
cord-001859-d62iuk72	165	24	(	(	-LRB-
cord-001859-d62iuk72	165	25	Fig	Fig	NNP
cord-001859-d62iuk72	165	26	3D	3d	NN
cord-001859-d62iuk72	165	27	)	)	-RRB-
cord-001859-d62iuk72	165	28	.	.	.
cord-001859-d62iuk72	166	1	These	these	DT
cord-001859-d62iuk72	166	2	results	result	NNS
cord-001859-d62iuk72	166	3	indicate	indicate	VBP
cord-001859-d62iuk72	166	4	that	that	IN
cord-001859-d62iuk72	166	5	the	the	DT
cord-001859-d62iuk72	166	6	observed	observed	JJ
cord-001859-d62iuk72	166	7	decrease	decrease	NN
cord-001859-d62iuk72	166	8	in	in	IN
cord-001859-d62iuk72	166	9	viral	viral	JJ
cord-001859-d62iuk72	166	10	protein	protein	NN
cord-001859-d62iuk72	166	11	synthesis	synthesis	NN
cord-001859-d62iuk72	166	12	was	be	VBD
cord-001859-d62iuk72	166	13	prior	prior	RB
cord-001859-d62iuk72	166	14	to	to	IN
cord-001859-d62iuk72	166	15	translation	translation	NN
cord-001859-d62iuk72	166	16	and	and	CC
cord-001859-d62iuk72	166	17	that	that	IN
cord-001859-d62iuk72	166	18	neither	neither	CC
cord-001859-d62iuk72	166	19	viral	viral	JJ
cord-001859-d62iuk72	166	20	RTA	RTA	NNP
cord-001859-d62iuk72	166	21	nor	nor	CC
cord-001859-d62iuk72	166	22	ORF57	ORF57	NNP
cord-001859-d62iuk72	166	23	protein	protein	NN
cord-001859-d62iuk72	166	24	were	be	VBD
cord-001859-d62iuk72	166	25	client	client	NN
cord-001859-d62iuk72	166	26	proteins	protein	NNS
cord-001859-d62iuk72	166	27	of	of	IN
cord-001859-d62iuk72	166	28	the	the	DT
cord-001859-d62iuk72	166	29	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	166	30	isoforms	isoform	NNS
cord-001859-d62iuk72	166	31	.	.	.
cord-001859-d62iuk72	167	1	As	as	IN
cord-001859-d62iuk72	167	2	such	such	JJ
cord-001859-d62iuk72	167	3	,	,	,
cord-001859-d62iuk72	167	4	this	this	DT
cord-001859-d62iuk72	167	5	highlights	highlight	VBZ
cord-001859-d62iuk72	167	6	a	a	DT
cord-001859-d62iuk72	167	7	potentially	potentially	RB
cord-001859-d62iuk72	167	8	novel	novel	JJ
cord-001859-d62iuk72	167	9	role	role	NN
cord-001859-d62iuk72	167	10	of	of	IN
cord-001859-d62iuk72	167	11	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	167	12	isoforms	isoform	NNS
cord-001859-d62iuk72	167	13	in	in	IN
cord-001859-d62iuk72	167	14	the	the	DT
cord-001859-d62iuk72	167	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	167	16	replication	replication	NN
cord-001859-d62iuk72	167	17	cycle	cycle	NN
cord-001859-d62iuk72	167	18	independent	independent	JJ
cord-001859-d62iuk72	167	19	of	of	IN
cord-001859-d62iuk72	167	20	viral	viral	JJ
cord-001859-d62iuk72	167	21	protein	protein	NN
cord-001859-d62iuk72	167	22	stability	stability	NN
cord-001859-d62iuk72	167	23	and	and	CC
cord-001859-d62iuk72	167	24	maturation	maturation	NN
cord-001859-d62iuk72	167	25	.	.	.
cord-001859-d62iuk72	168	1	To	to	TO
cord-001859-d62iuk72	168	2	further	further	RB
cord-001859-d62iuk72	168	3	corroborate	corroborate	VB
cord-001859-d62iuk72	168	4	these	these	DT
cord-001859-d62iuk72	168	5	results	result	NNS
cord-001859-d62iuk72	168	6	,	,	,
cord-001859-d62iuk72	168	7	experiments	experiment	NNS
cord-001859-d62iuk72	168	8	were	be	VBD
cord-001859-d62iuk72	168	9	also	also	RB
cord-001859-d62iuk72	168	10	repeated	repeat	VBN
cord-001859-d62iuk72	168	11	in	in	IN
cord-001859-d62iuk72	168	12	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	168	13	T	t	NN
cord-001859-d62iuk72	168	14	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	168	15	cells	cell	NNS
cord-001859-d62iuk72	168	16	.	.	.
cord-001859-d62iuk72	169	1	Again	again	RB
cord-001859-d62iuk72	169	2	,	,	,
cord-001859-d62iuk72	169	3	cell	cell	NN
cord-001859-d62iuk72	169	4	metabolic	metabolic	JJ
cord-001859-d62iuk72	169	5	activity	activity	NN
cord-001859-d62iuk72	169	6	,	,	,
cord-001859-d62iuk72	169	7	PARP1	PARP1	NNP
cord-001859-d62iuk72	169	8	cleavage	cleavage	NN
cord-001859-d62iuk72	169	9	,	,	,
cord-001859-d62iuk72	169	10	viability	viability	NN
cord-001859-d62iuk72	169	11	,	,	,
cord-001859-d62iuk72	169	12	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	169	13	and	and	CC
cord-001859-d62iuk72	169	14	activation	activation	NN
cord-001859-d62iuk72	169	15	of	of	IN
cord-001859-d62iuk72	169	16	caspases-3/7	caspases-3/7	NNP
cord-001859-d62iuk72	169	17	in	in	IN
cord-001859-d62iuk72	169	18	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	169	19	cells	cell	NNS
cord-001859-d62iuk72	169	20	were	be	VBD
cord-001859-d62iuk72	169	21	all	all	DT
cord-001859-d62iuk72	169	22	assessed	assess	VBN
cord-001859-d62iuk72	169	23	at	at	IN
cord-001859-d62iuk72	169	24	a	a	DT
cord-001859-d62iuk72	169	25	range	range	NN
cord-001859-d62iuk72	169	26	of	of	IN
cord-001859-d62iuk72	169	27	increasing	increase	VBG
cord-001859-d62iuk72	169	28	inhibitor	inhibitor	NN
cord-001859-d62iuk72	169	29	concentrations	concentration	NNS
cord-001859-d62iuk72	169	30	(	(	-LRB-
cord-001859-d62iuk72	169	31	Fig	fig	NN
cord-001859-d62iuk72	169	32	4A	4a	CD
cord-001859-d62iuk72	169	33	and	and	CC
cord-001859-d62iuk72	169	34	4B	4b	LS
cord-001859-d62iuk72	169	35	)	)	-RRB-
cord-001859-d62iuk72	169	36	.	.	.
cord-001859-d62iuk72	170	1	On	on	IN
cord-001859-d62iuk72	170	2	this	this	DT
cord-001859-d62iuk72	170	3	occasion	occasion	NN
cord-001859-d62iuk72	170	4	,	,	,
cord-001859-d62iuk72	170	5	the	the	DT
cord-001859-d62iuk72	170	6	inhibitor	inhibitor	NN
cord-001859-d62iuk72	170	7	did	do	VBD
cord-001859-d62iuk72	170	8	not	not	RB
cord-001859-d62iuk72	170	9	trigger	trigger	VB
cord-001859-d62iuk72	170	10	apoptosis	apoptosis	NN
cord-001859-d62iuk72	170	11	(	(	-LRB-
cord-001859-d62iuk72	170	12	Fig	Fig	NNP
cord-001859-d62iuk72	170	13	 	 	_SP
cord-001859-d62iuk72	170	14	4Aii	4aii	CD
cord-001859-d62iuk72	170	15	and	and	CC
cord-001859-d62iuk72	170	16	4B	4b	LS
cord-001859-d62iuk72	170	17	)	)	-RRB-
cord-001859-d62iuk72	170	18	but	but	CC
cord-001859-d62iuk72	170	19	it	-PRON-	PRP
cord-001859-d62iuk72	170	20	caused	cause	VBD
cord-001859-d62iuk72	170	21	a	a	DT
cord-001859-d62iuk72	170	22	pronounced	pronounce	VBN
cord-001859-d62iuk72	170	23	cell	cell	NN
cord-001859-d62iuk72	170	24	cycle	cycle	NN
cord-001859-d62iuk72	170	25	arrest	arrest	NN
cord-001859-d62iuk72	170	26	at	at	IN
cord-001859-d62iuk72	170	27	24	24	CD
cord-001859-d62iuk72	170	28	h	h	NN
cord-001859-d62iuk72	170	29	exposure	exposure	NN
cord-001859-d62iuk72	170	30	at	at	IN
cord-001859-d62iuk72	170	31	concentrations	concentration	NNS
cord-001859-d62iuk72	170	32	of	of	IN
cord-001859-d62iuk72	170	33	20	20	CD
cord-001859-d62iuk72	170	34	μM	μm	NN
cord-001859-d62iuk72	170	35	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	170	36	by	by	IN
cord-001859-d62iuk72	170	37	a	a	DT
cord-001859-d62iuk72	170	38	reduced	reduce	VBN
cord-001859-d62iuk72	170	39	number	number	NN
cord-001859-d62iuk72	170	40	of	of	IN
cord-001859-d62iuk72	170	41	metabolically	metabolically	RB
cord-001859-d62iuk72	170	42	active	active	JJ
cord-001859-d62iuk72	170	43	cells	cell	NNS
cord-001859-d62iuk72	170	44	that	that	WDT
cord-001859-d62iuk72	170	45	exhibited	exhibit	VBD
cord-001859-d62iuk72	170	46	no	no	DT
cord-001859-d62iuk72	170	47	increased	increase	VBN
cord-001859-d62iuk72	170	48	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	170	49	[	[	-LRB-
cord-001859-d62iuk72	170	50	63	63	CD
cord-001859-d62iuk72	170	51	]	]	-RRB-
cord-001859-d62iuk72	171	1	(	(	-LRB-
cord-001859-d62iuk72	171	2	Fig	Fig	NNP
cord-001859-d62iuk72	171	3	4B	4b	CD
cord-001859-d62iuk72	171	4	)	)	-RRB-
cord-001859-d62iuk72	171	5	.	.	.
cord-001859-d62iuk72	172	1	It	-PRON-	PRP
cord-001859-d62iuk72	172	2	is	be	VBZ
cord-001859-d62iuk72	172	3	known	know	VBN
cord-001859-d62iuk72	172	4	that	that	IN
cord-001859-d62iuk72	172	5	the	the	DT
cord-001859-d62iuk72	172	6	apoptotic	apoptotic	JJ
cord-001859-d62iuk72	172	7	potential	potential	NN
cord-001859-d62iuk72	172	8	of	of	IN
cord-001859-d62iuk72	172	9	VER-155008	ver-155008	NN
cord-001859-d62iuk72	172	10	is	be	VBZ
cord-001859-d62iuk72	172	11	cell	cell	NN
cord-001859-d62iuk72	172	12	line	line	NN
cord-001859-d62iuk72	172	13	-	-	HYPH
cord-001859-d62iuk72	172	14	dependent	dependent	JJ
cord-001859-d62iuk72	172	15	and	and	CC
cord-001859-d62iuk72	172	16	that	that	IN
cord-001859-d62iuk72	172	17	VER-155008	ver-155008	NN
cord-001859-d62iuk72	172	18	can	can	MD
cord-001859-d62iuk72	172	19	cause	cause	VB
cord-001859-d62iuk72	172	20	cell	cell	NN
cord-001859-d62iuk72	172	21	cycle	cycle	NN
cord-001859-d62iuk72	172	22	arrest	arrest	NN
cord-001859-d62iuk72	172	23	in	in	IN
cord-001859-d62iuk72	172	24	human	human	JJ
cord-001859-d62iuk72	172	25	colon	colon	NN
cord-001859-d62iuk72	172	26	,	,	,
cord-001859-d62iuk72	172	27	breast	breast	NN
cord-001859-d62iuk72	172	28	and	and	CC
cord-001859-d62iuk72	172	29	lung	lung	NN
cord-001859-d62iuk72	172	30	tumour	tumour	NN
cord-001859-d62iuk72	172	31	cell	cell	NN
cord-001859-d62iuk72	172	32	lines	line	NNS
cord-001859-d62iuk72	172	33	[	[	-LRB-
cord-001859-d62iuk72	172	34	54	54	CD
cord-001859-d62iuk72	172	35	,	,	,
cord-001859-d62iuk72	172	36	64	64	CD
cord-001859-d62iuk72	172	37	]	]	-RRB-
cord-001859-d62iuk72	172	38	.	.	.
cord-001859-d62iuk72	173	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	174	1	T	T	NNP
cord-001859-d62iuk72	174	2	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	174	3	cells	cell	NNS
cord-001859-d62iuk72	174	4	were	be	VBD
cord-001859-d62iuk72	174	5	also	also	RB
cord-001859-d62iuk72	174	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	174	7	for	for	IN
cord-001859-d62iuk72	174	8	24	24	CD
cord-001859-d62iuk72	174	9	h	h	NN
cord-001859-d62iuk72	174	10	in	in	IN
cord-001859-d62iuk72	174	11	the	the	DT
cord-001859-d62iuk72	174	12	presence	presence	NN
cord-001859-d62iuk72	174	13	of	of	IN
cord-001859-d62iuk72	174	14	drug	drug	NN
cord-001859-d62iuk72	174	15	vehicle	vehicle	NN
cord-001859-d62iuk72	174	16	DMSO	DMSO	NNP
cord-001859-d62iuk72	174	17	(	(	-LRB-
cord-001859-d62iuk72	174	18	0.1	0.1	CD
cord-001859-d62iuk72	174	19	%	%	NN
cord-001859-d62iuk72	174	20	)	)	-RRB-
cord-001859-d62iuk72	174	21	or	or	CC
cord-001859-d62iuk72	174	22	increasing	increase	VBG
cord-001859-d62iuk72	174	23	inhibitor	inhibitor	NN
cord-001859-d62iuk72	174	24	concentrations	concentration	NNS
cord-001859-d62iuk72	174	25	.	.	.
cord-001859-d62iuk72	175	1	Endogenous	Endogenous	NNP
cord-001859-d62iuk72	175	2	RTA	RTA	NNP
cord-001859-d62iuk72	175	3	,	,	,
cord-001859-d62iuk72	175	4	ORF57	ORF57	NNP
cord-001859-d62iuk72	175	5	and	and	CC
cord-001859-d62iuk72	175	6	mCapsid	mCapsid	NNP
cord-001859-d62iuk72	175	7	protein	protein	NN
cord-001859-d62iuk72	175	8	levels	level	NNS
cord-001859-d62iuk72	175	9	were	be	VBD
cord-001859-d62iuk72	175	10	moderately	moderately	RB
cord-001859-d62iuk72	175	11	reduced	reduce	VBN
cord-001859-d62iuk72	175	12	in	in	IN
cord-001859-d62iuk72	175	13	cells	cell	NNS
cord-001859-d62iuk72	175	14	treated	treat	VBN
cord-001859-d62iuk72	175	15	at	at	IN
cord-001859-d62iuk72	175	16	an	an	DT
cord-001859-d62iuk72	175	17	inhibitor	inhibitor	NN
cord-001859-d62iuk72	175	18	concentration	concentration	NN
cord-001859-d62iuk72	175	19	of	of	IN
cord-001859-d62iuk72	175	20	10	10	CD
cord-001859-d62iuk72	175	21	μM	μM	NNS
cord-001859-d62iuk72	175	22	and	and	CC
cord-001859-d62iuk72	175	23	severely	severely	RB
cord-001859-d62iuk72	175	24	reduced	reduce	VBN
cord-001859-d62iuk72	175	25	at	at	IN
cord-001859-d62iuk72	175	26	40	40	CD
cord-001859-d62iuk72	175	27	μM	μm	CD
cord-001859-d62iuk72	175	28	while	while	IN
cord-001859-d62iuk72	175	29	cellular	cellular	JJ
cord-001859-d62iuk72	175	30	proteins	protein	NNS
cord-001859-d62iuk72	175	31	remain	remain	VBP
cord-001859-d62iuk72	175	32	unaffected	unaffected	JJ
cord-001859-d62iuk72	175	33	(	(	-LRB-
cord-001859-d62iuk72	175	34	Fig	Fig	NNP
cord-001859-d62iuk72	175	35	4C	4c	CD
cord-001859-d62iuk72	175	36	)	)	-RRB-
cord-001859-d62iuk72	175	37	.	.	.
cord-001859-d62iuk72	176	1	These	these	DT
cord-001859-d62iuk72	176	2	were	be	VBD
cord-001859-d62iuk72	176	3	relatively	relatively	RB
cord-001859-d62iuk72	176	4	high	high	JJ
cord-001859-d62iuk72	176	5	inhibitor	inhibitor	NN
cord-001859-d62iuk72	176	6	concentrations	concentration	NNS
cord-001859-d62iuk72	176	7	compared	compare	VBN
cord-001859-d62iuk72	176	8	with	with	IN
cord-001859-d62iuk72	176	9	TREx	TREx	NNS
cord-001859-d62iuk72	176	10	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	176	11	cells	cell	NNS
cord-001859-d62iuk72	176	12	;	;	:
cord-001859-d62iuk72	176	13	nonetheless	nonetheless	RB
cord-001859-d62iuk72	176	14	a	a	DT
cord-001859-d62iuk72	176	15	concentration	concentration	NN
cord-001859-d62iuk72	176	16	of	of	IN
cord-001859-d62iuk72	176	17	40	40	CD
cord-001859-d62iuk72	176	18	μM	μM	NNP
cord-001859-d62iuk72	176	19	has	have	VBZ
cord-001859-d62iuk72	176	20	been	be	VBN
cord-001859-d62iuk72	176	21	shown	show	VBN
cord-001859-d62iuk72	176	22	before	before	RB
cord-001859-d62iuk72	176	23	to	to	TO
cord-001859-d62iuk72	176	24	be	be	VB
cord-001859-d62iuk72	176	25	necessary	necessary	JJ
cord-001859-d62iuk72	176	26	for	for	IN
cord-001859-d62iuk72	176	27	inhibition	inhibition	NN
cord-001859-d62iuk72	176	28	of	of	IN
cord-001859-d62iuk72	176	29	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	176	30	isoforms	isoform	NNS
cord-001859-d62iuk72	176	31	in	in	IN
cord-001859-d62iuk72	176	32	human	human	JJ
cord-001859-d62iuk72	176	33	carcinoma	carcinoma	NN
cord-001859-d62iuk72	176	34	cell	cell	NN
cord-001859-d62iuk72	176	35	lines	line	NNS
cord-001859-d62iuk72	176	36	[	[	-LRB-
cord-001859-d62iuk72	176	37	54	54	CD
cord-001859-d62iuk72	176	38	]	]	-RRB-
cord-001859-d62iuk72	176	39	.	.	.
cord-001859-d62iuk72	177	1	As	as	IN
cord-001859-d62iuk72	177	2	previously	previously	RB
cord-001859-d62iuk72	177	3	seen	see	VBN
cord-001859-d62iuk72	177	4	in	in	IN
cord-001859-d62iuk72	177	5	TREx	TREx	NNS
cord-001859-d62iuk72	177	6	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	177	7	cells	cell	NNS
cord-001859-d62iuk72	177	8	,	,	,
cord-001859-d62iuk72	177	9	when	when	WRB
cord-001859-d62iuk72	177	10	blocking	block	VBG
cord-001859-d62iuk72	177	11	de	de	NNP
cord-001859-d62iuk72	177	12	novo	novo	NNP
cord-001859-d62iuk72	177	13	protein	protein	NN
cord-001859-d62iuk72	177	14	synthesis	synthesis	NN
cord-001859-d62iuk72	177	15	with	with	IN
cord-001859-d62iuk72	177	16	CHX	CHX	NNP
cord-001859-d62iuk72	177	17	at	at	IN
cord-001859-d62iuk72	177	18	100	100	CD
cord-001859-d62iuk72	177	19	μg	μg	NNP
cord-001859-d62iuk72	177	20	/	/	SYM
cord-001859-d62iuk72	177	21	ml	ml	XX
cord-001859-d62iuk72	177	22	in	in	IN
cord-001859-d62iuk72	177	23	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	177	24	T	t	NN
cord-001859-d62iuk72	177	25	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	177	26	cells	cell	NNS
cord-001859-d62iuk72	177	27	,	,	,
cord-001859-d62iuk72	177	28	the	the	DT
cord-001859-d62iuk72	177	29	half	half	JJ
cord-001859-d62iuk72	177	30	-	-	HYPH
cord-001859-d62iuk72	177	31	life	life	NN
cord-001859-d62iuk72	177	32	of	of	IN
cord-001859-d62iuk72	177	33	RTA	RTA	NNP
cord-001859-d62iuk72	177	34	and	and	CC
cord-001859-d62iuk72	177	35	ORF57	ORF57	NNP
cord-001859-d62iuk72	177	36	proteins	protein	NNS
cord-001859-d62iuk72	177	37	were	be	VBD
cord-001859-d62iuk72	177	38	not	not	RB
cord-001859-d62iuk72	177	39	reduced	reduce	VBN
cord-001859-d62iuk72	177	40	even	even	RB
cord-001859-d62iuk72	177	41	in	in	IN
cord-001859-d62iuk72	177	42	the	the	DT
cord-001859-d62iuk72	177	43	presence	presence	NN
cord-001859-d62iuk72	177	44	of	of	IN
cord-001859-d62iuk72	177	45	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	177	46	at	at	IN
cord-001859-d62iuk72	177	47	50	50	CD
cord-001859-d62iuk72	177	48	μM	μm	CD
cord-001859-d62iuk72	178	1	(	(	-LRB-
cord-001859-d62iuk72	178	2	Fig	Fig	NNP
cord-001859-d62iuk72	178	3	4D	4d	CD
cord-001859-d62iuk72	178	4	)	)	-RRB-
cord-001859-d62iuk72	178	5	.	.	.
cord-001859-d62iuk72	179	1	This	this	DT
cord-001859-d62iuk72	179	2	supports	support	VBZ
cord-001859-d62iuk72	179	3	the	the	DT
cord-001859-d62iuk72	179	4	findings	finding	NNS
cord-001859-d62iuk72	179	5	seen	see	VBN
cord-001859-d62iuk72	179	6	in	in	IN
cord-001859-d62iuk72	179	7	TREx	TREx	NNS
cord-001859-d62iuk72	179	8	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	179	9	cells	cell	NNS
cord-001859-d62iuk72	179	10	,	,	,
cord-001859-d62iuk72	179	11	suggesting	suggest	VBG
cord-001859-d62iuk72	179	12	that	that	IN
cord-001859-d62iuk72	179	13	the	the	DT
cord-001859-d62iuk72	179	14	decrease	decrease	NN
cord-001859-d62iuk72	179	15	in	in	IN
cord-001859-d62iuk72	179	16	viral	viral	JJ
cord-001859-d62iuk72	179	17	protein	protein	NN
cord-001859-d62iuk72	179	18	production	production	NN
cord-001859-d62iuk72	179	19	was	be	VBD
cord-001859-d62iuk72	179	20	due	due	JJ
cord-001859-d62iuk72	179	21	to	to	IN
cord-001859-d62iuk72	179	22	a	a	DT
cord-001859-d62iuk72	179	23	pretranslation	pretranslation	NN
cord-001859-d62iuk72	179	24	event	event	NN
cord-001859-d62iuk72	179	25	.	.	.
cord-001859-d62iuk72	180	1	using	use	VBG
cord-001859-d62iuk72	180	2	an	an	DT
cord-001859-d62iuk72	180	3	MTS	MTS	NNP
cord-001859-d62iuk72	180	4	assay	assay	NN
cord-001859-d62iuk72	180	5	.	.	.
cord-001859-d62iuk72	181	1	(	(	-LRB-
cord-001859-d62iuk72	181	2	ii	ii	NN
cord-001859-d62iuk72	181	3	)	)	-RRB-
cord-001859-d62iuk72	182	1	A	a	DT
cord-001859-d62iuk72	182	2	dose	dose	NN
cord-001859-d62iuk72	182	3	-	-	HYPH
cord-001859-d62iuk72	182	4	dependent	dependent	JJ
cord-001859-d62iuk72	182	5	cleavage	cleavage	NN
cord-001859-d62iuk72	182	6	of	of	IN
cord-001859-d62iuk72	182	7	full	full	JJ
cord-001859-d62iuk72	182	8	length	length	NN
cord-001859-d62iuk72	183	1	(	(	-LRB-
cord-001859-d62iuk72	183	2	FL	FL	NNP
cord-001859-d62iuk72	183	3	)	)	-RRB-
cord-001859-d62iuk72	183	4	PARP1	PARP1	VBZ
cord-001859-d62iuk72	183	5	protein	protein	NN
cord-001859-d62iuk72	183	6	into	into	IN
cord-001859-d62iuk72	183	7	cleaved	cleave	VBN
cord-001859-d62iuk72	183	8	(	(	-LRB-
cord-001859-d62iuk72	183	9	CL	CL	NNP
cord-001859-d62iuk72	183	10	)	)	-RRB-
cord-001859-d62iuk72	183	11	PARP1	PARP1	NNP
cord-001859-d62iuk72	183	12	was	be	VBD
cord-001859-d62iuk72	183	13	observed	observe	VBN
cord-001859-d62iuk72	183	14	in	in	IN
cord-001859-d62iuk72	183	15	the	the	DT
cord-001859-d62iuk72	183	16	presence	presence	NN
cord-001859-d62iuk72	183	17	of	of	IN
cord-001859-d62iuk72	183	18	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	183	19	.	.	.
cord-001859-d62iuk72	184	1	(	(	-LRB-
cord-001859-d62iuk72	184	2	B	b	NN
cord-001859-d62iuk72	184	3	)	)	-RRB-
cord-001859-d62iuk72	184	4	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	184	5	cells	cell	NNS
cord-001859-d62iuk72	184	6	were	be	VBD
cord-001859-d62iuk72	184	7	exposed	expose	VBN
cord-001859-d62iuk72	184	8	for	for	IN
cord-001859-d62iuk72	184	9	24	24	CD
cord-001859-d62iuk72	184	10	h	h	NN
cord-001859-d62iuk72	184	11	to	to	IN
cord-001859-d62iuk72	184	12	increasing	increase	VBG
cord-001859-d62iuk72	184	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	184	14	concentrations	concentration	NNS
cord-001859-d62iuk72	184	15	.	.	.
cord-001859-d62iuk72	185	1	Concentrations	concentration	NNS
cord-001859-d62iuk72	185	2	higher	high	JJR
cord-001859-d62iuk72	185	3	than	than	IN
cord-001859-d62iuk72	185	4	3	3	CD
cord-001859-d62iuk72	185	5	μM	μm	NN
cord-001859-d62iuk72	185	6	resulted	result	VBD
cord-001859-d62iuk72	185	7	in	in	IN
cord-001859-d62iuk72	185	8	increased	increase	VBN
cord-001859-d62iuk72	185	9	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	185	10	and	and	CC
cord-001859-d62iuk72	185	11	activation	activation	NN
cord-001859-d62iuk72	185	12	of	of	IN
cord-001859-d62iuk72	185	13	effector	effector	NN
cord-001859-d62iuk72	185	14	caspases-3/7	caspases-3/7	NNP
cord-001859-d62iuk72	185	15	as	as	IN
cord-001859-d62iuk72	185	16	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	185	17	by	by	IN
cord-001859-d62iuk72	185	18	quantification	quantification	NN
cord-001859-d62iuk72	185	19	with	with	IN
cord-001859-d62iuk72	185	20	ApoTox	ApoTox	NNP
cord-001859-d62iuk72	185	21	-	-	HYPH
cord-001859-d62iuk72	185	22	Glo	Glo	NNP
cord-001859-d62iuk72	185	23	Triplex	Triplex	NNP
cord-001859-d62iuk72	185	24	Assay	Assay	NNP
cord-001859-d62iuk72	185	25	.	.	.
cord-001859-d62iuk72	186	1	(	(	-LRB-
cord-001859-d62iuk72	186	2	C	C	NNP
cord-001859-d62iuk72	186	3	)	)	-RRB-
cord-001859-d62iuk72	186	4	Immunoblot	Immunoblot	NNP
cord-001859-d62iuk72	186	5	analysis	analysis	NN
cord-001859-d62iuk72	186	6	showing	show	VBG
cord-001859-d62iuk72	186	7	that	that	IN
cord-001859-d62iuk72	186	8	reactivated	reactivate	VBN
cord-001859-d62iuk72	186	9	cells	cell	NNS
cord-001859-d62iuk72	186	10	treated	treat	VBN
cord-001859-d62iuk72	186	11	with	with	IN
cord-001859-d62iuk72	186	12	non	non	JJ
cord-001859-d62iuk72	186	13	-	-	JJ
cord-001859-d62iuk72	186	14	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	186	15	inhibitor	inhibitor	NN
cord-001859-d62iuk72	186	16	concentrations	concentration	NNS
cord-001859-d62iuk72	186	17	(	(	-LRB-
cord-001859-d62iuk72	186	18	1	1	CD
cord-001859-d62iuk72	186	19	to	to	IN
cord-001859-d62iuk72	186	20	2.5	2.5	CD
cord-001859-d62iuk72	186	21	μM	μM	NNS
cord-001859-d62iuk72	186	22	)	)	-RRB-
cord-001859-d62iuk72	186	23	for	for	IN
cord-001859-d62iuk72	186	24	24	24	CD
cord-001859-d62iuk72	186	25	h	h	NNP
cord-001859-d62iuk72	186	26	revealed	reveal	VBD
cord-001859-d62iuk72	186	27	a	a	DT
cord-001859-d62iuk72	186	28	decrease	decrease	NN
cord-001859-d62iuk72	186	29	in	in	IN
cord-001859-d62iuk72	186	30	viral	viral	JJ
cord-001859-d62iuk72	186	31	proteins	protein	NNS
cord-001859-d62iuk72	186	32	compared	compare	VBN
cord-001859-d62iuk72	186	33	with	with	IN
cord-001859-d62iuk72	186	34	DMSO	DMSO	NNP
cord-001859-d62iuk72	186	35	-	-	HYPH
cord-001859-d62iuk72	186	36	treated	treat	VBN
cord-001859-d62iuk72	186	37	samples	sample	NNS
cord-001859-d62iuk72	186	38	while	while	IN
cord-001859-d62iuk72	186	39	cellular	cellular	JJ
cord-001859-d62iuk72	186	40	proteins	protein	NNS
cord-001859-d62iuk72	186	41	remained	remain	VBD
cord-001859-d62iuk72	186	42	unaffected	unaffected	JJ
cord-001859-d62iuk72	186	43	.	.	.
cord-001859-d62iuk72	187	1	RNAPIIo	RNAPIIo	NNP
cord-001859-d62iuk72	187	2	denotes	denote	VBZ
cord-001859-d62iuk72	187	3	hypophosphorylated	hypophosphorylate	VBN
cord-001859-d62iuk72	187	4	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	187	5	.	.	.
cord-001859-d62iuk72	188	1	Ser5	Ser5	NNP
cord-001859-d62iuk72	188	2	and	and	CC
cord-001859-d62iuk72	188	3	Ser2	Ser2	NNP
cord-001859-d62iuk72	188	4	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	188	5	denote	denote	VBP
cord-001859-d62iuk72	188	6	serine	serine	NN
cord-001859-d62iuk72	188	7	5-and	5-and	CD
cord-001859-d62iuk72	188	8	serine	serine	NN
cord-001859-d62iuk72	188	9	2hyperphosphorylated	2hyperphosphorylated	CD
cord-001859-d62iuk72	188	10	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	188	11	forms	form	NNS
cord-001859-d62iuk72	188	12	respectively	respectively	RB
cord-001859-d62iuk72	188	13	.	.	.
cord-001859-d62iuk72	189	1	(	(	-LRB-
cord-001859-d62iuk72	189	2	D	D	NNP
cord-001859-d62iuk72	189	3	)	)	-RRB-
cord-001859-d62iuk72	189	4	Cells	cell	NNS
cord-001859-d62iuk72	189	5	were	be	VBD
cord-001859-d62iuk72	189	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	189	7	for	for	IN
cord-001859-d62iuk72	189	8	24	24	CD
cord-001859-d62iuk72	189	9	h	h	NN
cord-001859-d62iuk72	189	10	to	to	TO
cord-001859-d62iuk72	189	11	allow	allow	VB
cord-001859-d62iuk72	189	12	robust	robust	JJ
cord-001859-d62iuk72	189	13	viral	viral	JJ
cord-001859-d62iuk72	189	14	protein	protein	NN
cord-001859-d62iuk72	189	15	production	production	NN
cord-001859-d62iuk72	189	16	.	.	.
cord-001859-d62iuk72	190	1	Then	then	RB
cord-001859-d62iuk72	190	2	,	,	,
cord-001859-d62iuk72	190	3	DMSO	DMSO	NNP
cord-001859-d62iuk72	190	4	control	control	NN
cord-001859-d62iuk72	190	5	(	(	-LRB-
cord-001859-d62iuk72	190	6	0.1	0.1	CD
cord-001859-d62iuk72	190	7	%	%	NN
cord-001859-d62iuk72	190	8	)	)	-RRB-
cord-001859-d62iuk72	190	9	or	or	CC
cord-001859-d62iuk72	190	10	VER-155008	ver-155008	NN
cord-001859-d62iuk72	190	11	was	be	VBD
cord-001859-d62iuk72	190	12	added	add	VBN
cord-001859-d62iuk72	190	13	in	in	IN
cord-001859-d62iuk72	190	14	conjunction	conjunction	NN
cord-001859-d62iuk72	190	15	with	with	IN
cord-001859-d62iuk72	190	16	cycloheximide	cycloheximide	NN
cord-001859-d62iuk72	190	17	(	(	-LRB-
cord-001859-d62iuk72	190	18	CHX	CHX	NNP
cord-001859-d62iuk72	190	19	)	)	-RRB-
cord-001859-d62iuk72	190	20	at	at	IN
cord-001859-d62iuk72	190	21	50	50	CD
cord-001859-d62iuk72	190	22	μg	μg	NNS
cord-001859-d62iuk72	190	23	/	/	SYM
cord-001859-d62iuk72	190	24	ml	ml	NN
cord-001859-d62iuk72	190	25	to	to	TO
cord-001859-d62iuk72	190	26	block	block	VB
cord-001859-d62iuk72	190	27	de	de	NNP
cord-001859-d62iuk72	190	28	novo	novo	NNP
cord-001859-d62iuk72	190	29	protein	protein	NNP
cord-001859-d62iuk72	190	30	synthesis	synthesis	NN
cord-001859-d62iuk72	190	31	.	.	.
cord-001859-d62iuk72	191	1	Protein	protein	NN
cord-001859-d62iuk72	191	2	lysates	lysate	NNS
cord-001859-d62iuk72	191	3	were	be	VBD
cord-001859-d62iuk72	191	4	collected	collect	VBN
cord-001859-d62iuk72	191	5	at	at	IN
cord-001859-d62iuk72	191	6	several	several	JJ
cord-001859-d62iuk72	191	7	times	time	NNS
cord-001859-d62iuk72	191	8	post	post	JJ
cord-001859-d62iuk72	191	9	-	-	JJ
cord-001859-d62iuk72	191	10	CHX	chx	JJ
cord-001859-d62iuk72	191	11	addition	addition	NN
cord-001859-d62iuk72	191	12	(	(	-LRB-
cord-001859-d62iuk72	191	13	0	0	CD
cord-001859-d62iuk72	191	14	,	,	,
cord-001859-d62iuk72	191	15	4	4	CD
cord-001859-d62iuk72	191	16	,	,	,
cord-001859-d62iuk72	191	17	8	8	CD
cord-001859-d62iuk72	191	18	,	,	,
cord-001859-d62iuk72	191	19	16	16	CD
cord-001859-d62iuk72	191	20	and	and	CC
cord-001859-d62iuk72	191	21	24	24	CD
cord-001859-d62iuk72	191	22	h	h	NN
cord-001859-d62iuk72	191	23	)	)	-RRB-
cord-001859-d62iuk72	191	24	and	and	CC
cord-001859-d62iuk72	191	25	analysed	analyse	VBN
cord-001859-d62iuk72	191	26	by	by	IN
cord-001859-d62iuk72	191	27	Western	western	JJ
cord-001859-d62iuk72	191	28	blotting	blotting	NN
cord-001859-d62iuk72	191	29	.	.	.
cord-001859-d62iuk72	192	1	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	192	2	did	do	VBD
cord-001859-d62iuk72	192	3	not	not	RB
cord-001859-d62iuk72	192	4	alter	alter	VB
cord-001859-d62iuk72	192	5	the	the	DT
cord-001859-d62iuk72	192	6	half	half	JJ
cord-001859-d62iuk72	192	7	-	-	HYPH
cord-001859-d62iuk72	192	8	life	life	NN
cord-001859-d62iuk72	192	9	of	of	IN
cord-001859-d62iuk72	192	10	RTA	RTA	NNP
cord-001859-d62iuk72	192	11	or	or	CC
cord-001859-d62iuk72	192	12	ORF57	ORF57	NNP
cord-001859-d62iuk72	192	13	protein	protein	NN
cord-001859-d62iuk72	192	14	,	,	,
cord-001859-d62iuk72	192	15	thus	thus	RB
cord-001859-d62iuk72	192	16	these	these	DT
cord-001859-d62iuk72	192	17	proteins	protein	NNS
cord-001859-d62iuk72	192	18	were	be	VBD
cord-001859-d62iuk72	192	19	not	not	RB
cord-001859-d62iuk72	192	20	clients	client	NNS
cord-001859-d62iuk72	192	21	of	of	IN
cord-001859-d62iuk72	192	22	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	192	23	isoforms	isoform	NNS
cord-001859-d62iuk72	192	24	.	.	.
cord-001859-d62iuk72	193	1	The	the	DT
cord-001859-d62iuk72	193	2	small	small	JJ
cord-001859-d62iuk72	193	3	molecule	molecule	NN
cord-001859-d62iuk72	193	4	inhibitor	inhibitor	NN
cord-001859-d62iuk72	193	5	VER-155008	ver-155008	NN
cord-001859-d62iuk72	193	6	caused	cause	VBD
cord-001859-d62iuk72	193	7	a	a	DT
cord-001859-d62iuk72	193	8	significant	significant	JJ
cord-001859-d62iuk72	193	9	reduction	reduction	NN
cord-001859-d62iuk72	193	10	in	in	IN
cord-001859-d62iuk72	193	11	viral	viral	JJ
cord-001859-d62iuk72	193	12	transcripts	transcript	NNS
cord-001859-d62iuk72	193	13	,	,	,
cord-001859-d62iuk72	193	14	viral	viral	JJ
cord-001859-d62iuk72	193	15	DNA	dna	NN
cord-001859-d62iuk72	193	16	and	and	CC
cord-001859-d62iuk72	193	17	progeny	progeny	NN
cord-001859-d62iuk72	193	18	at	at	IN
cord-001859-d62iuk72	193	19	non	non	JJ
cord-001859-d62iuk72	193	20	-	-	JJ
cord-001859-d62iuk72	193	21	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	193	22	concentrations	concentration	NNS
cord-001859-d62iuk72	194	1	As	as	IN
cord-001859-d62iuk72	194	2	the	the	DT
cord-001859-d62iuk72	194	3	block	block	NN
cord-001859-d62iuk72	194	4	in	in	IN
cord-001859-d62iuk72	194	5	KSHV	KSHV	NNP
cord-001859-d62iuk72	194	6	protein	protein	NN
cord-001859-d62iuk72	194	7	synthesis	synthesis	NN
cord-001859-d62iuk72	194	8	occurred	occur	VBD
cord-001859-d62iuk72	194	9	pre	pre	NN
cord-001859-d62iuk72	194	10	-	-	NN
cord-001859-d62iuk72	194	11	translationally	translationally	RB
cord-001859-d62iuk72	194	12	,	,	,
cord-001859-d62iuk72	194	13	viral	viral	JJ
cord-001859-d62iuk72	194	14	gene	gene	NN
cord-001859-d62iuk72	194	15	expression	expression	NN
cord-001859-d62iuk72	194	16	was	be	VBD
cord-001859-d62iuk72	194	17	quantified	quantify	VBN
cord-001859-d62iuk72	194	18	in	in	IN
cord-001859-d62iuk72	194	19	the	the	DT
cord-001859-d62iuk72	194	20	absence	absence	NN
cord-001859-d62iuk72	194	21	or	or	CC
cord-001859-d62iuk72	194	22	presence	presence	NN
cord-001859-d62iuk72	194	23	of	of	IN
cord-001859-d62iuk72	194	24	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	194	25	.	.	.
cord-001859-d62iuk72	195	1	TREx	TREx	NNP
cord-001859-d62iuk72	195	2	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	195	3	cells	cell	NNS
cord-001859-d62iuk72	195	4	were	be	VBD
cord-001859-d62iuk72	195	5	reactivated	reactivate	VBN
cord-001859-d62iuk72	195	6	for	for	IN
cord-001859-d62iuk72	195	7	24	24	CD
cord-001859-d62iuk72	195	8	h	h	NN
cord-001859-d62iuk72	195	9	and	and	CC
cord-001859-d62iuk72	195	10	two	two	CD
cord-001859-d62iuk72	195	11	-	-	HYPH
cord-001859-d62iuk72	195	12	step	step	NN
cord-001859-d62iuk72	195	13	quantitative	quantitative	JJ
cord-001859-d62iuk72	195	14	reverse	reverse	NN
cord-001859-d62iuk72	195	15	transcription	transcription	NN
cord-001859-d62iuk72	195	16	PCR	PCR	NNP
cord-001859-d62iuk72	195	17	(	(	-LRB-
cord-001859-d62iuk72	195	18	qRT	qRT	NNP
cord-001859-d62iuk72	195	19	-	-	HYPH
cord-001859-d62iuk72	195	20	PCR	PCR	NNP
cord-001859-d62iuk72	195	21	)	)	-RRB-
cord-001859-d62iuk72	195	22	was	be	VBD
cord-001859-d62iuk72	195	23	carried	carry	VBN
cord-001859-d62iuk72	195	24	out	out	RP
cord-001859-d62iuk72	195	25	to	to	TO
cord-001859-d62iuk72	195	26	quantify	quantify	VB
cord-001859-d62iuk72	195	27	a	a	DT
cord-001859-d62iuk72	195	28	range	range	NN
cord-001859-d62iuk72	195	29	of	of	IN
cord-001859-d62iuk72	195	30	viral	viral	JJ
cord-001859-d62iuk72	195	31	transcripts	transcript	NNS
cord-001859-d62iuk72	195	32	.	.	.
cord-001859-d62iuk72	196	1	A	a	DT
cord-001859-d62iuk72	196	2	significant	significant	JJ
cord-001859-d62iuk72	196	3	decrease	decrease	NN
cord-001859-d62iuk72	196	4	in	in	IN
cord-001859-d62iuk72	196	5	early	early	JJ
cord-001859-d62iuk72	196	6	(	(	-LRB-
cord-001859-d62iuk72	196	7	PAN	PAN	NNP
cord-001859-d62iuk72	196	8	,	,	,
cord-001859-d62iuk72	196	9	ORF57	ORF57	NNP
cord-001859-d62iuk72	196	10	,	,	,
cord-001859-d62iuk72	196	11	K12	K12	NNP
cord-001859-d62iuk72	196	12	and	and	CC
cord-001859-d62iuk72	196	13	vGPCR	vGPCR	NNP
cord-001859-d62iuk72	196	14	)	)	-RRB-
cord-001859-d62iuk72	196	15	,	,	,
cord-001859-d62iuk72	196	16	late	late	JJ
cord-001859-d62iuk72	196	17	(	(	-LRB-
cord-001859-d62iuk72	196	18	gL	gl	NN
cord-001859-d62iuk72	196	19	and	and	CC
cord-001859-d62iuk72	196	20	gB	gB	NNP
cord-001859-d62iuk72	196	21	)	)	-RRB-
cord-001859-d62iuk72	196	22	viral	viral	JJ
cord-001859-d62iuk72	196	23	transcripts	transcript	NNS
cord-001859-d62iuk72	196	24	and	and	CC
cord-001859-d62iuk72	196	25	ori	ori	NNP
cord-001859-d62iuk72	196	26	-	-	HYPH
cord-001859-d62iuk72	196	27	Lyt	Lyt	NNP
cord-001859-d62iuk72	196	28	transcripts	transcript	NNS
cord-001859-d62iuk72	196	29	was	be	VBD
cord-001859-d62iuk72	196	30	observed	observe	VBN
cord-001859-d62iuk72	196	31	in	in	IN
cord-001859-d62iuk72	196	32	a	a	DT
cord-001859-d62iuk72	196	33	dose	dose	NN
cord-001859-d62iuk72	196	34	-	-	HYPH
cord-001859-d62iuk72	196	35	dependent	dependent	JJ
cord-001859-d62iuk72	196	36	manner	manner	NN
cord-001859-d62iuk72	196	37	,	,	,
cord-001859-d62iuk72	196	38	with	with	IN
cord-001859-d62iuk72	196	39	all	all	DT
cord-001859-d62iuk72	196	40	transcripts	transcript	NNS
cord-001859-d62iuk72	196	41	with	with	IN
cord-001859-d62iuk72	196	42	the	the	DT
cord-001859-d62iuk72	196	43	exception	exception	NN
cord-001859-d62iuk72	196	44	of	of	IN
cord-001859-d62iuk72	196	45	vGPCR	vGPCR	NNP
cord-001859-d62iuk72	196	46	being	be	VBG
cord-001859-d62iuk72	196	47	significantly	significantly	RB
cord-001859-d62iuk72	196	48	reduced	reduce	VBN
cord-001859-d62iuk72	196	49	at	at	IN
cord-001859-d62iuk72	196	50	an	an	DT
cord-001859-d62iuk72	196	51	inhibitor	inhibitor	NN
cord-001859-d62iuk72	196	52	concentration	concentration	NN
cord-001859-d62iuk72	196	53	of	of	IN
cord-001859-d62iuk72	196	54	1	1	CD
cord-001859-d62iuk72	196	55	μM	μM	NNP
cord-001859-d62iuk72	196	56	(	(	-LRB-
cord-001859-d62iuk72	196	57	Fig	Fig	NNP
cord-001859-d62iuk72	196	58	5A	5a	NN
cord-001859-d62iuk72	196	59	)	)	-RRB-
cord-001859-d62iuk72	196	60	.	.	.
cord-001859-d62iuk72	197	1	To	to	TO
cord-001859-d62iuk72	197	2	determine	determine	VB
cord-001859-d62iuk72	197	3	whether	whether	IN
cord-001859-d62iuk72	197	4	cellular	cellular	JJ
cord-001859-d62iuk72	197	5	transcription	transcription	NN
cord-001859-d62iuk72	197	6	was	be	VBD
cord-001859-d62iuk72	197	7	negatively	negatively	RB
cord-001859-d62iuk72	197	8	affected	affect	VBN
cord-001859-d62iuk72	197	9	in	in	IN
cord-001859-d62iuk72	197	10	the	the	DT
cord-001859-d62iuk72	197	11	presence	presence	NN
cord-001859-d62iuk72	197	12	of	of	IN
cord-001859-d62iuk72	197	13	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	197	14	,	,	,
cord-001859-d62iuk72	197	15	firstly	firstly	RB
cord-001859-d62iuk72	197	16	the	the	DT
cord-001859-d62iuk72	197	17	stability	stability	NN
cord-001859-d62iuk72	197	18	of	of	IN
cord-001859-d62iuk72	197	19	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	197	20	transcript	transcript	NN
cord-001859-d62iuk72	197	21	was	be	VBD
cord-001859-d62iuk72	197	22	determined	determine	VBN
cord-001859-d62iuk72	197	23	in	in	IN
cord-001859-d62iuk72	197	24	mRNA	mRNA	NNP
cord-001859-d62iuk72	197	25	decay	decay	NN
cord-001859-d62iuk72	197	26	assays	assay	NNS
cord-001859-d62iuk72	197	27	using	use	VBG
cord-001859-d62iuk72	197	28	the	the	DT
cord-001859-d62iuk72	197	29	transcriptional	transcriptional	JJ
cord-001859-d62iuk72	197	30	inhibitor	inhibitor	NN
cord-001859-d62iuk72	197	31	actinomycin	actinomycin	NNS
cord-001859-d62iuk72	197	32	D	D	NNP
cord-001859-d62iuk72	197	33	(	(	-LRB-
cord-001859-d62iuk72	197	34	AcD	AcD	NNP
cord-001859-d62iuk72	197	35	)	)	-RRB-
cord-001859-d62iuk72	197	36	(	(	-LRB-
cord-001859-d62iuk72	197	37	2.5	2.5	CD
cord-001859-d62iuk72	197	38	μg	μg	NNS
cord-001859-d62iuk72	197	39	/	/	SYM
cord-001859-d62iuk72	197	40	ml	ml	NNP
cord-001859-d62iuk72	197	41	)	)	-RRB-
cord-001859-d62iuk72	197	42	in	in	IN
cord-001859-d62iuk72	197	43	TREx	TREx	NNS
cord-001859-d62iuk72	197	44	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	197	45	cells	cell	NNS
cord-001859-d62iuk72	197	46	.	.	.
cord-001859-d62iuk72	198	1	After	after	IN
cord-001859-d62iuk72	198	2	6	6	CD
cord-001859-d62iuk72	198	3	h	h	NN
cord-001859-d62iuk72	198	4	of	of	IN
cord-001859-d62iuk72	198	5	AcD	acd	JJ
cord-001859-d62iuk72	198	6	treatment	treatment	NN
cord-001859-d62iuk72	198	7	,	,	,
cord-001859-d62iuk72	198	8	the	the	DT
cord-001859-d62iuk72	198	9	amount	amount	NN
cord-001859-d62iuk72	198	10	of	of	IN
cord-001859-d62iuk72	198	11	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	198	12	mRNA	mRNA	NNP
cord-001859-d62iuk72	198	13	was	be	VBD
cord-001859-d62iuk72	198	14	reduced	reduce	VBN
cord-001859-d62iuk72	198	15	by	by	IN
cord-001859-d62iuk72	198	16	half	half	NN
cord-001859-d62iuk72	198	17	(	(	-LRB-
cord-001859-d62iuk72	198	18	Fig	Fig	NNP
cord-001859-d62iuk72	198	19	5B	5b	NN
cord-001859-d62iuk72	198	20	)	)	-RRB-
cord-001859-d62iuk72	198	21	,	,	,
cord-001859-d62iuk72	198	22	indicating	indicate	VBG
cord-001859-d62iuk72	198	23	a	a	DT
cord-001859-d62iuk72	198	24	short	short	JJ
cord-001859-d62iuk72	198	25	stability	stability	NN
cord-001859-d62iuk72	198	26	of	of	IN
cord-001859-d62iuk72	198	27	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	198	28	mRNA	mrna	NN
cord-001859-d62iuk72	198	29	in	in	IN
cord-001859-d62iuk72	198	30	this	this	DT
cord-001859-d62iuk72	198	31	cell	cell	NN
cord-001859-d62iuk72	198	32	line	line	NN
cord-001859-d62iuk72	198	33	.	.	.
cord-001859-d62iuk72	199	1	We	-PRON-	PRP
cord-001859-d62iuk72	199	2	then	then	RB
cord-001859-d62iuk72	199	3	plotted	plot	VBD
cord-001859-d62iuk72	199	4	the	the	DT
cord-001859-d62iuk72	199	5	raw	raw	JJ
cord-001859-d62iuk72	199	6	cycle	cycle	NN
cord-001859-d62iuk72	199	7	threshold	threshold	NN
cord-001859-d62iuk72	199	8	(	(	-LRB-
cord-001859-d62iuk72	199	9	C	C	NNP
cord-001859-d62iuk72	199	10	T	T	NNP
cord-001859-d62iuk72	199	11	)	)	-RRB-
cord-001859-d62iuk72	199	12	for	for	IN
cord-001859-d62iuk72	199	13	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	199	14	transcript	transcript	NN
cord-001859-d62iuk72	199	15	from	from	IN
cord-001859-d62iuk72	199	16	the	the	DT
cord-001859-d62iuk72	199	17	same	same	JJ
cord-001859-d62iuk72	199	18	samples	sample	NNS
cord-001859-d62iuk72	199	19	in	in	IN
cord-001859-d62iuk72	199	20	which	which	WDT
cord-001859-d62iuk72	199	21	viral	viral	JJ
cord-001859-d62iuk72	199	22	transcripts	transcript	NNS
cord-001859-d62iuk72	199	23	had	have	VBD
cord-001859-d62iuk72	199	24	been	be	VBN
cord-001859-d62iuk72	199	25	quantified	quantify	VBN
cord-001859-d62iuk72	199	26	after	after	IN
cord-001859-d62iuk72	199	27	24	24	CD
cord-001859-d62iuk72	199	28	h	h	NN
cord-001859-d62iuk72	199	29	of	of	IN
cord-001859-d62iuk72	199	30	VER-155008	ver-155008	JJ
cord-001859-d62iuk72	199	31	treatment	treatment	NN
cord-001859-d62iuk72	199	32	.	.	.
cord-001859-d62iuk72	200	1	As	as	IN
cord-001859-d62iuk72	200	2	the	the	DT
cord-001859-d62iuk72	200	3	same	same	JJ
cord-001859-d62iuk72	200	4	amount	amount	NN
cord-001859-d62iuk72	200	5	of	of	IN
cord-001859-d62iuk72	200	6	total	total	JJ
cord-001859-d62iuk72	200	7	RNA	RNA	NNP
cord-001859-d62iuk72	200	8	was	be	VBD
cord-001859-d62iuk72	200	9	converted	convert	VBN
cord-001859-d62iuk72	200	10	into	into	IN
cord-001859-d62iuk72	200	11	cDNA	cdna	NN
cord-001859-d62iuk72	200	12	for	for	IN
cord-001859-d62iuk72	200	13	all	all	DT
cord-001859-d62iuk72	200	14	samples	sample	NNS
cord-001859-d62iuk72	200	15	,	,	,
cord-001859-d62iuk72	200	16	if	if	IN
cord-001859-d62iuk72	200	17	cellular	cellular	JJ
cord-001859-d62iuk72	200	18	transcription	transcription	NN
cord-001859-d62iuk72	200	19	was	be	VBD
cord-001859-d62iuk72	200	20	not	not	RB
cord-001859-d62iuk72	200	21	compromised	compromise	VBN
cord-001859-d62iuk72	200	22	a	a	DT
cord-001859-d62iuk72	200	23	very	very	RB
cord-001859-d62iuk72	200	24	similar	similar	JJ
cord-001859-d62iuk72	200	25	C	c	NN
cord-001859-d62iuk72	200	26	T	t	NN
cord-001859-d62iuk72	200	27	is	be	VBZ
cord-001859-d62iuk72	200	28	expected	expect	VBN
cord-001859-d62iuk72	200	29	for	for	IN
cord-001859-d62iuk72	200	30	all	all	DT
cord-001859-d62iuk72	200	31	samples	sample	NNS
cord-001859-d62iuk72	200	32	.	.	.
cord-001859-d62iuk72	201	1	Indeed	indeed	RB
cord-001859-d62iuk72	201	2	,	,	,
cord-001859-d62iuk72	201	3	samples	sample	NNS
cord-001859-d62iuk72	201	4	treated	treat	VBN
cord-001859-d62iuk72	201	5	with	with	IN
cord-001859-d62iuk72	201	6	up	up	IN
cord-001859-d62iuk72	201	7	to	to	TO
cord-001859-d62iuk72	201	8	3	3	CD
cord-001859-d62iuk72	202	1	μM	μM	NNP
cord-001859-d62iuk72	203	1	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	203	2	were	be	VBD
cord-001859-d62iuk72	203	3	all	all	DT
cord-001859-d62iuk72	203	4	within	within	IN
cord-001859-d62iuk72	203	5	0.4	0.4	CD
cord-001859-d62iuk72	203	6	C	c	NN
cord-001859-d62iuk72	203	7	T	t	NN
cord-001859-d62iuk72	203	8	from	from	IN
cord-001859-d62iuk72	203	9	the	the	DT
cord-001859-d62iuk72	203	10	12.7	12.7	CD
cord-001859-d62iuk72	203	11	C	c	NN
cord-001859-d62iuk72	203	12	T	t	NN
cord-001859-d62iuk72	203	13	of	of	IN
cord-001859-d62iuk72	203	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	203	15	-	-	HYPH
cord-001859-d62iuk72	203	16	treated	treat	VBN
cord-001859-d62iuk72	203	17	samples	sample	NNS
cord-001859-d62iuk72	203	18	.	.	.
cord-001859-d62iuk72	204	1	Only	only	RB
cord-001859-d62iuk72	204	2	after	after	IN
cord-001859-d62iuk72	204	3	concentrations	concentration	NNS
cord-001859-d62iuk72	204	4	higher	high	JJR
cord-001859-d62iuk72	204	5	than	than	IN
cord-001859-d62iuk72	204	6	3	3	CD
cord-001859-d62iuk72	205	1	μM	μM	NNP
cord-001859-d62iuk72	206	1	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	206	2	mRNA	mrna	NN
cord-001859-d62iuk72	206	3	levels	level	NNS
cord-001859-d62iuk72	206	4	were	be	VBD
cord-001859-d62iuk72	206	5	significantly	significantly	RB
cord-001859-d62iuk72	206	6	reduced	reduce	VBN
cord-001859-d62iuk72	206	7	compared	compare	VBN
cord-001859-d62iuk72	206	8	to	to	IN
cord-001859-d62iuk72	206	9	DMSO	DMSO	NNP
cord-001859-d62iuk72	206	10	-	-	HYPH
cord-001859-d62iuk72	206	11	treated	treat	VBN
cord-001859-d62iuk72	206	12	samples	sample	NNS
cord-001859-d62iuk72	206	13	as	as	IN
cord-001859-d62iuk72	206	14	shown	show	VBN
cord-001859-d62iuk72	206	15	by	by	IN
cord-001859-d62iuk72	206	16	a	a	DT
cord-001859-d62iuk72	206	17	significantly	significantly	RB
cord-001859-d62iuk72	206	18	higher	high	JJR
cord-001859-d62iuk72	206	19	C	c	NN
cord-001859-d62iuk72	206	20	T	t	NN
cord-001859-d62iuk72	206	21	value	value	NN
cord-001859-d62iuk72	206	22	(	(	-LRB-
cord-001859-d62iuk72	206	23	Fig	Fig	NNP
cord-001859-d62iuk72	206	24	5C	5c	CD
cord-001859-d62iuk72	206	25	)	)	-RRB-
cord-001859-d62iuk72	206	26	.	.	.
cord-001859-d62iuk72	207	1	This	this	DT
cord-001859-d62iuk72	207	2	is	be	VBZ
cord-001859-d62iuk72	207	3	consistent	consistent	JJ
cord-001859-d62iuk72	207	4	with	with	IN
cord-001859-d62iuk72	207	5	the	the	DT
cord-001859-d62iuk72	207	6	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	207	7	profile	profile	NN
cord-001859-d62iuk72	207	8	of	of	IN
cord-001859-d62iuk72	207	9	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	207	10	in	in	IN
cord-001859-d62iuk72	207	11	TREx	TREx	NNS
cord-001859-d62iuk72	207	12	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	207	13	cells	cell	NNS
cord-001859-d62iuk72	207	14	(	(	-LRB-
cord-001859-d62iuk72	207	15	Fig	Fig	NNP
cord-001859-d62iuk72	207	16	3A	3a	NN
cord-001859-d62iuk72	207	17	and	and	CC
cord-001859-d62iuk72	207	18	3B	3B	NNP
cord-001859-d62iuk72	207	19	)	)	-RRB-
cord-001859-d62iuk72	207	20	and	and	CC
cord-001859-d62iuk72	207	21	the	the	DT
cord-001859-d62iuk72	207	22	clear	clear	JJ
cord-001859-d62iuk72	207	23	decrease	decrease	NN
cord-001859-d62iuk72	207	24	in	in	IN
cord-001859-d62iuk72	207	25	RTA	RTA	NNP
cord-001859-d62iuk72	207	26	-	-	HYPH
cord-001859-d62iuk72	207	27	myc	myc	NNP
cord-001859-d62iuk72	207	28	protein	protein	NN
cord-001859-d62iuk72	207	29	(	(	-LRB-
cord-001859-d62iuk72	207	30	which	which	WDT
cord-001859-d62iuk72	207	31	expression	expression	NN
cord-001859-d62iuk72	207	32	is	be	VBZ
cord-001859-d62iuk72	207	33	not	not	RB
cord-001859-d62iuk72	207	34	from	from	IN
cord-001859-d62iuk72	207	35	the	the	DT
cord-001859-d62iuk72	207	36	KSHV	KSHV	NNP
cord-001859-d62iuk72	207	37	genome	genome	NN
cord-001859-d62iuk72	207	38	)	)	-RRB-
cord-001859-d62iuk72	207	39	at	at	IN
cord-001859-d62iuk72	207	40	inhibitor	inhibitor	NN
cord-001859-d62iuk72	207	41	concentrations	concentration	NNS
cord-001859-d62iuk72	207	42	higher	high	JJR
cord-001859-d62iuk72	207	43	than	than	IN
cord-001859-d62iuk72	207	44	3	3	CD
cord-001859-d62iuk72	208	1	μM	μM	NNP
cord-001859-d62iuk72	209	1	(	(	-LRB-
cord-001859-d62iuk72	209	2	Fig	Fig	NNP
cord-001859-d62iuk72	209	3	 	 	_SP
cord-001859-d62iuk72	209	4	3C	3c	NN
cord-001859-d62iuk72	209	5	)	)	-RRB-
cord-001859-d62iuk72	209	6	.	.	.
cord-001859-d62iuk72	210	1	Taken	take	VBN
cord-001859-d62iuk72	210	2	together	together	RB
cord-001859-d62iuk72	210	3	,	,	,
cord-001859-d62iuk72	210	4	these	these	DT
cord-001859-d62iuk72	210	5	results	result	NNS
cord-001859-d62iuk72	210	6	suggest	suggest	VBP
cord-001859-d62iuk72	210	7	that	that	IN
cord-001859-d62iuk72	210	8	cellular	cellular	JJ
cord-001859-d62iuk72	210	9	transcription	transcription	NN
cord-001859-d62iuk72	210	10	was	be	VBD
cord-001859-d62iuk72	210	11	compromised	compromise	VBN
cord-001859-d62iuk72	210	12	at	at	IN
cord-001859-d62iuk72	210	13	concentrations	concentration	NNS
cord-001859-d62iuk72	210	14	of	of	IN
cord-001859-d62iuk72	210	15	VER-155008	ver-155008	NN
cord-001859-d62iuk72	210	16	higher	high	JJR
cord-001859-d62iuk72	210	17	than	than	IN
cord-001859-d62iuk72	210	18	3	3	CD
cord-001859-d62iuk72	210	19	μM	μm	CD
cord-001859-d62iuk72	210	20	while	while	IN
cord-001859-d62iuk72	210	21	at	at	IN
cord-001859-d62iuk72	210	22	concentrations	concentration	NNS
cord-001859-d62iuk72	210	23	lower	low	JJR
cord-001859-d62iuk72	210	24	than	than	IN
cord-001859-d62iuk72	210	25	3	3	CD
cord-001859-d62iuk72	211	1	μM	μm	CD
cord-001859-d62iuk72	211	2	transcription	transcription	NN
cord-001859-d62iuk72	211	3	was	be	VBD
cord-001859-d62iuk72	211	4	occurring	occur	VBG
cord-001859-d62iuk72	211	5	normally	normally	RB
cord-001859-d62iuk72	211	6	.	.	.
cord-001859-d62iuk72	212	1	Interestingly	interestingly	RB
cord-001859-d62iuk72	212	2	,	,	,
cord-001859-d62iuk72	212	3	transcription	transcription	NN
cord-001859-d62iuk72	212	4	of	of	IN
cord-001859-d62iuk72	212	5	viral	viral	JJ
cord-001859-d62iuk72	212	6	genes	gene	NNS
cord-001859-d62iuk72	212	7	which	which	WDT
cord-001859-d62iuk72	212	8	also	also	RB
cord-001859-d62iuk72	212	9	require	require	VBP
cord-001859-d62iuk72	212	10	host	host	NN
cord-001859-d62iuk72	212	11	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	212	12	for	for	IN
cord-001859-d62iuk72	212	13	their	-PRON-	PRP$
cord-001859-d62iuk72	212	14	expression	expression	NN
cord-001859-d62iuk72	212	15	was	be	VBD
cord-001859-d62iuk72	212	16	negatively	negatively	RB
cord-001859-d62iuk72	212	17	affected	affect	VBN
cord-001859-d62iuk72	212	18	even	even	RB
cord-001859-d62iuk72	212	19	at	at	IN
cord-001859-d62iuk72	212	20	VER-155008	ver-155008	NN
cord-001859-d62iuk72	212	21	concentrations	concentration	NNS
cord-001859-d62iuk72	212	22	lower	low	JJR
cord-001859-d62iuk72	212	23	than	than	IN
cord-001859-d62iuk72	212	24	3	3	CD
cord-001859-d62iuk72	213	1	μM.	μM.	NNP
cord-001859-d62iuk72	213	2	Next	Next	NNP
cord-001859-d62iuk72	213	3	,	,	,
cord-001859-d62iuk72	213	4	we	-PRON-	PRP
cord-001859-d62iuk72	213	5	assessed	assess	VBD
cord-001859-d62iuk72	213	6	whether	whether	IN
cord-001859-d62iuk72	213	7	the	the	DT
cord-001859-d62iuk72	213	8	inhibitor	inhibitor	NN
cord-001859-d62iuk72	213	9	also	also	RB
cord-001859-d62iuk72	213	10	caused	cause	VBD
cord-001859-d62iuk72	213	11	a	a	DT
cord-001859-d62iuk72	213	12	reduction	reduction	NN
cord-001859-d62iuk72	213	13	in	in	IN
cord-001859-d62iuk72	213	14	viral	viral	JJ
cord-001859-d62iuk72	213	15	DNA	dna	NN
cord-001859-d62iuk72	213	16	replication	replication	NN
cord-001859-d62iuk72	213	17	.	.	.
cord-001859-d62iuk72	214	1	TREx	TREx	NNP
cord-001859-d62iuk72	214	2	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	214	3	cells	cell	NNS
cord-001859-d62iuk72	214	4	were	be	VBD
cord-001859-d62iuk72	214	5	reactivated	reactivate	VBN
cord-001859-d62iuk72	214	6	for	for	IN
cord-001859-d62iuk72	214	7	72	72	CD
cord-001859-d62iuk72	214	8	h	h	NN
cord-001859-d62iuk72	214	9	,	,	,
cord-001859-d62iuk72	214	10	total	total	JJ
cord-001859-d62iuk72	214	11	DNA	DNA	NNP
cord-001859-d62iuk72	214	12	was	be	VBD
cord-001859-d62iuk72	214	13	isolated	isolate	VBN
cord-001859-d62iuk72	214	14	and	and	CC
cord-001859-d62iuk72	214	15	realtime	realtime	NNP
cord-001859-d62iuk72	214	16	qPCR	qPCR	NNP
cord-001859-d62iuk72	214	17	was	be	VBD
cord-001859-d62iuk72	214	18	performed	perform	VBN
cord-001859-d62iuk72	214	19	using	use	VBG
cord-001859-d62iuk72	214	20	primers	primer	NNS
cord-001859-d62iuk72	214	21	specific	specific	JJ
cord-001859-d62iuk72	214	22	for	for	IN
cord-001859-d62iuk72	214	23	ORF57	ORF57	NNP
cord-001859-d62iuk72	214	24	.	.	.
cord-001859-d62iuk72	215	1	While	while	IN
cord-001859-d62iuk72	215	2	DMSO	DMSO	NNP
cord-001859-d62iuk72	215	3	-	-	HYPH
cord-001859-d62iuk72	215	4	treated	treat	VBN
cord-001859-d62iuk72	215	5	cells	cell	NNS
cord-001859-d62iuk72	215	6	reached~9-fold	reached~9-fold	IN
cord-001859-d62iuk72	215	7	increase	increase	VBP
cord-001859-d62iuk72	215	8	in	in	IN
cord-001859-d62iuk72	215	9	viral	viral	JJ
cord-001859-d62iuk72	215	10	DNA	dna	NN
cord-001859-d62iuk72	215	11	load	load	NN
cord-001859-d62iuk72	215	12	,	,	,
cord-001859-d62iuk72	215	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	215	14	concentrations	concentration	NNS
cord-001859-d62iuk72	215	15	of	of	IN
cord-001859-d62iuk72	215	16	2	2	CD
cord-001859-d62iuk72	215	17	μM	μm	NN
cord-001859-d62iuk72	215	18	or	or	CC
cord-001859-d62iuk72	215	19	higher	high	JJR
cord-001859-d62iuk72	215	20	resulted	result	VBD
cord-001859-d62iuk72	215	21	in	in	IN
cord-001859-d62iuk72	215	22	a	a	DT
cord-001859-d62iuk72	215	23	significant	significant	JJ
cord-001859-d62iuk72	215	24	reduction	reduction	NN
cord-001859-d62iuk72	215	25	(	(	-LRB-
cord-001859-d62iuk72	215	26	>	>	NFP
cord-001859-d62iuk72	215	27	30	30	CD
cord-001859-d62iuk72	215	28	%	%	NN
cord-001859-d62iuk72	215	29	)	)	-RRB-
cord-001859-d62iuk72	215	30	in	in	IN
cord-001859-d62iuk72	215	31	viral	viral	JJ
cord-001859-d62iuk72	215	32	DNA	dna	NN
cord-001859-d62iuk72	215	33	(	(	-LRB-
cord-001859-d62iuk72	215	34	Fig	Fig	NNP
cord-001859-d62iuk72	215	35	5D	5d	CD
cord-001859-d62iuk72	215	36	)	)	-RRB-
cord-001859-d62iuk72	215	37	.	.	.
cord-001859-d62iuk72	216	1	Moreover	moreover	RB
cord-001859-d62iuk72	216	2	,	,	,
cord-001859-d62iuk72	216	3	the	the	DT
cord-001859-d62iuk72	216	4	production	production	NN
cord-001859-d62iuk72	216	5	of	of	IN
cord-001859-d62iuk72	216	6	infectious	infectious	JJ
cord-001859-d62iuk72	216	7	KSHV	KSHV	NNP
cord-001859-d62iuk72	216	8	virions	virion	NNS
cord-001859-d62iuk72	216	9	in	in	IN
cord-001859-d62iuk72	216	10	TREx	TREx	NNS
cord-001859-d62iuk72	216	11	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	216	12	cells	cell	NNS
cord-001859-d62iuk72	216	13	was	be	VBD
cord-001859-d62iuk72	216	14	evaluated	evaluate	VBN
cord-001859-d62iuk72	216	15	in	in	IN
cord-001859-d62iuk72	216	16	the	the	DT
cord-001859-d62iuk72	216	17	presence	presence	NN
cord-001859-d62iuk72	216	18	of	of	IN
cord-001859-d62iuk72	216	19	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	216	20	at	at	IN
cord-001859-d62iuk72	216	21	2.5	2.5	CD
cord-001859-d62iuk72	216	22	μM	μm	CD
cord-001859-d62iuk72	216	23	or	or	CC
cord-001859-d62iuk72	216	24	vehicle	vehicle	NN
cord-001859-d62iuk72	216	25	drug	drug	NN
cord-001859-d62iuk72	216	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	216	27	.	.	.
cord-001859-d62iuk72	217	1	For	for	IN
cord-001859-d62iuk72	217	2	this	this	DT
cord-001859-d62iuk72	217	3	,	,	,
cord-001859-d62iuk72	217	4	cells	cell	NNS
cord-001859-d62iuk72	217	5	were	be	VBD
cord-001859-d62iuk72	217	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	217	7	and	and	CC
cord-001859-d62iuk72	217	8	treated	treat	VBN
cord-001859-d62iuk72	217	9	for	for	IN
cord-001859-d62iuk72	217	10	72	72	CD
cord-001859-d62iuk72	217	11	h	h	NN
cord-001859-d62iuk72	217	12	,	,	,
cord-001859-d62iuk72	217	13	culture	culture	NN
cord-001859-d62iuk72	217	14	medium	medium	NN
cord-001859-d62iuk72	217	15	was	be	VBD
cord-001859-d62iuk72	217	16	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	217	17	and	and	CC
cord-001859-d62iuk72	217	18	incubated	incubate	VBN
cord-001859-d62iuk72	217	19	for	for	IN
cord-001859-d62iuk72	217	20	24	24	CD
cord-001859-d62iuk72	217	21	h	h	NN
cord-001859-d62iuk72	217	22	with	with	IN
cord-001859-d62iuk72	217	23	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	217	24	T	T	NNP
cord-001859-d62iuk72	217	25	cells	cell	NNS
cord-001859-d62iuk72	217	26	.	.	.
cord-001859-d62iuk72	218	1	Total	Total	NNP
cord-001859-d62iuk72	218	2	RNA	RNA	NNP
cord-001859-d62iuk72	218	3	was	be	VBD
cord-001859-d62iuk72	218	4	then	then	RB
cord-001859-d62iuk72	218	5	isolated	isolate	VBN
cord-001859-d62iuk72	218	6	and	and	CC
cord-001859-d62iuk72	218	7	qRT	qRT	NNP
cord-001859-d62iuk72	218	8	-	-	HYPH
cord-001859-d62iuk72	218	9	PCR	PCR	NNP
cord-001859-d62iuk72	218	10	carried	carry	VBD
cord-001859-d62iuk72	218	11	out	out	RP
cord-001859-d62iuk72	218	12	.	.	.
cord-001859-d62iuk72	219	1	A	a	DT
cord-001859-d62iuk72	219	2	significant	significant	JJ
cord-001859-d62iuk72	219	3	reduction	reduction	NN
cord-001859-d62iuk72	219	4	(	(	-LRB-
cord-001859-d62iuk72	219	5	~80	~80	CD
cord-001859-d62iuk72	219	6	%	%	NN
cord-001859-d62iuk72	219	7	)	)	-RRB-
cord-001859-d62iuk72	219	8	in	in	IN
cord-001859-d62iuk72	219	9	the	the	DT
cord-001859-d62iuk72	219	10	release	release	NN
cord-001859-d62iuk72	219	11	of	of	IN
cord-001859-d62iuk72	219	12	infectious	infectious	JJ
cord-001859-d62iuk72	219	13	viral	viral	JJ
cord-001859-d62iuk72	219	14	progeny	progeny	NN
cord-001859-d62iuk72	219	15	was	be	VBD
cord-001859-d62iuk72	219	16	observed	observe	VBN
cord-001859-d62iuk72	219	17	in	in	IN
cord-001859-d62iuk72	219	18	inhibitor	inhibitor	NN
cord-001859-d62iuk72	219	19	-	-	HYPH
cord-001859-d62iuk72	219	20	treated	treat	VBN
cord-001859-d62iuk72	219	21	cells	cell	NNS
cord-001859-d62iuk72	219	22	(	(	-LRB-
cord-001859-d62iuk72	219	23	Fig	Fig	NNP
cord-001859-d62iuk72	219	24	5E	5e	NN
cord-001859-d62iuk72	219	25	)	)	-RRB-
cord-001859-d62iuk72	219	26	.	.	.
cord-001859-d62iuk72	220	1	Viral	viral	JJ
cord-001859-d62iuk72	220	2	transcripts	transcript	NNS
cord-001859-d62iuk72	220	3	were	be	VBD
cord-001859-d62iuk72	220	4	also	also	RB
cord-001859-d62iuk72	220	5	quantified	quantify	VBN
cord-001859-d62iuk72	220	6	at	at	IN
cord-001859-d62iuk72	220	7	24	24	CD
cord-001859-d62iuk72	220	8	h	h	NN
cord-001859-d62iuk72	220	9	reactivation	reactivation	NN
cord-001859-d62iuk72	220	10	in	in	IN
cord-001859-d62iuk72	220	11	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	220	12	T	t	NN
cord-001859-d62iuk72	220	13	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	220	14	cells	cell	NNS
cord-001859-d62iuk72	220	15	in	in	IN
cord-001859-d62iuk72	220	16	the	the	DT
cord-001859-d62iuk72	220	17	absence	absence	NN
cord-001859-d62iuk72	220	18	or	or	CC
cord-001859-d62iuk72	220	19	presence	presence	NN
cord-001859-d62iuk72	220	20	of	of	IN
cord-001859-d62iuk72	220	21	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	220	22	.	.	.
cord-001859-d62iuk72	221	1	At	at	IN
cord-001859-d62iuk72	221	2	non	non	JJ
cord-001859-d62iuk72	221	3	-	-	JJ
cord-001859-d62iuk72	221	4	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	221	5	concentrations	concentration	NNS
cord-001859-d62iuk72	221	6	of	of	IN
cord-001859-d62iuk72	221	7	10	10	CD
cord-001859-d62iuk72	221	8	μM	μM	NNS
cord-001859-d62iuk72	221	9	there	there	EX
cord-001859-d62iuk72	221	10	was	be	VBD
cord-001859-d62iuk72	221	11	a	a	DT
cord-001859-d62iuk72	221	12	drastic	drastic	JJ
cord-001859-d62iuk72	221	13	decrease	decrease	NN
cord-001859-d62iuk72	221	14	for	for	IN
cord-001859-d62iuk72	221	15	all	all	DT
cord-001859-d62iuk72	221	16	PARP1	parp1	NN
cord-001859-d62iuk72	221	17	was	be	VBD
cord-001859-d62iuk72	221	18	observed	observe	VBN
cord-001859-d62iuk72	221	19	faintly	faintly	RB
cord-001859-d62iuk72	221	20	.	.	.
cord-001859-d62iuk72	222	1	(	(	-LRB-
cord-001859-d62iuk72	222	2	B	b	NN
cord-001859-d62iuk72	222	3	)	)	-RRB-
cord-001859-d62iuk72	222	4	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	222	5	cells	cell	NNS
cord-001859-d62iuk72	222	6	were	be	VBD
cord-001859-d62iuk72	222	7	exposed	expose	VBN
cord-001859-d62iuk72	222	8	for	for	IN
cord-001859-d62iuk72	222	9	24	24	CD
cord-001859-d62iuk72	222	10	h	h	NN
cord-001859-d62iuk72	222	11	to	to	IN
cord-001859-d62iuk72	222	12	increasing	increase	VBG
cord-001859-d62iuk72	222	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	222	14	concentrations	concentration	NNS
cord-001859-d62iuk72	222	15	.	.	.
cord-001859-d62iuk72	223	1	A	a	DT
cord-001859-d62iuk72	223	2	reduced	reduced	JJ
cord-001859-d62iuk72	223	3	number	number	NN
cord-001859-d62iuk72	223	4	of	of	IN
cord-001859-d62iuk72	223	5	metabolically	metabolically	RB
cord-001859-d62iuk72	223	6	active	active	JJ
cord-001859-d62iuk72	223	7	cells	cell	NNS
cord-001859-d62iuk72	223	8	accompanied	accompany	VBN
cord-001859-d62iuk72	223	9	by	by	IN
cord-001859-d62iuk72	223	10	no	no	DT
cord-001859-d62iuk72	223	11	increased	increase	VBN
cord-001859-d62iuk72	223	12	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	223	13	was	be	VBD
cord-001859-d62iuk72	223	14	observed	observe	VBN
cord-001859-d62iuk72	223	15	in	in	IN
cord-001859-d62iuk72	223	16	the	the	DT
cord-001859-d62iuk72	223	17	presence	presence	NN
cord-001859-d62iuk72	223	18	of	of	IN
cord-001859-d62iuk72	223	19	the	the	DT
cord-001859-d62iuk72	223	20	inhibitor	inhibitor	NN
cord-001859-d62iuk72	223	21	.	.	.
cord-001859-d62iuk72	224	1	There	there	EX
cord-001859-d62iuk72	224	2	was	be	VBD
cord-001859-d62iuk72	224	3	no	no	DT
cord-001859-d62iuk72	224	4	activation	activation	NN
cord-001859-d62iuk72	224	5	of	of	IN
cord-001859-d62iuk72	224	6	effector	effector	NN
cord-001859-d62iuk72	224	7	caspases	caspase	NNS
cord-001859-d62iuk72	224	8	even	even	RB
cord-001859-d62iuk72	224	9	in	in	IN
cord-001859-d62iuk72	224	10	the	the	DT
cord-001859-d62iuk72	224	11	presence	presence	NN
cord-001859-d62iuk72	224	12	of	of	IN
cord-001859-d62iuk72	224	13	60	60	CD
cord-001859-d62iuk72	224	14	μM	μm	CD
cord-001859-d62iuk72	224	15	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	224	16	.	.	.
cord-001859-d62iuk72	225	1	This	this	DT
cord-001859-d62iuk72	225	2	phenotype	phenotype	NN
cord-001859-d62iuk72	225	3	is	be	VBZ
cord-001859-d62iuk72	225	4	consistent	consistent	JJ
cord-001859-d62iuk72	225	5	with	with	IN
cord-001859-d62iuk72	225	6	cell	cell	NN
cord-001859-d62iuk72	225	7	cycle	cycle	NN
cord-001859-d62iuk72	225	8	arrest	arrest	NN
cord-001859-d62iuk72	225	9	.	.	.
cord-001859-d62iuk72	226	1	Results	result	NNS
cord-001859-d62iuk72	226	2	were	be	VBD
cord-001859-d62iuk72	226	3	quantified	quantify	VBN
cord-001859-d62iuk72	226	4	with	with	IN
cord-001859-d62iuk72	226	5	ApoTox	ApoTox	NNP
cord-001859-d62iuk72	226	6	-	-	HYPH
cord-001859-d62iuk72	226	7	Glo	Glo	NNP
cord-001859-d62iuk72	226	8	Triplex	Triplex	NNP
cord-001859-d62iuk72	226	9	Assay	Assay	NNP
cord-001859-d62iuk72	226	10	.	.	.
cord-001859-d62iuk72	227	1	(	(	-LRB-
cord-001859-d62iuk72	227	2	C	C	NNP
cord-001859-d62iuk72	227	3	)	)	-RRB-
cord-001859-d62iuk72	227	4	Immunoblot	Immunoblot	NNP
cord-001859-d62iuk72	227	5	analysis	analysis	NN
cord-001859-d62iuk72	227	6	showing	show	VBG
cord-001859-d62iuk72	227	7	that	that	IN
cord-001859-d62iuk72	227	8	reactivated	reactivate	VBN
cord-001859-d62iuk72	227	9	cells	cell	NNS
cord-001859-d62iuk72	227	10	treated	treat	VBN
cord-001859-d62iuk72	227	11	with	with	IN
cord-001859-d62iuk72	227	12	40	40	CD
cord-001859-d62iuk72	227	13	μM	μm	CD
cord-001859-d62iuk72	227	14	VER-155008	ver-155008	NN
cord-001859-d62iuk72	227	15	for	for	IN
cord-001859-d62iuk72	227	16	24	24	CD
cord-001859-d62iuk72	227	17	h	h	NNP
cord-001859-d62iuk72	227	18	resulted	result	VBD
cord-001859-d62iuk72	227	19	in	in	IN
cord-001859-d62iuk72	227	20	abrogation	abrogation	NN
cord-001859-d62iuk72	227	21	of	of	IN
cord-001859-d62iuk72	227	22	viral	viral	JJ
cord-001859-d62iuk72	227	23	proteins	protein	NNS
cord-001859-d62iuk72	227	24	compared	compare	VBN
cord-001859-d62iuk72	227	25	with	with	IN
cord-001859-d62iuk72	227	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	227	27	-	-	HYPH
cord-001859-d62iuk72	227	28	treated	treat	VBN
cord-001859-d62iuk72	227	29	samples	sample	NNS
cord-001859-d62iuk72	227	30	while	while	IN
cord-001859-d62iuk72	227	31	cellular	cellular	JJ
cord-001859-d62iuk72	227	32	proteins	protein	NNS
cord-001859-d62iuk72	227	33	remained	remain	VBD
cord-001859-d62iuk72	227	34	constant	constant	JJ
cord-001859-d62iuk72	227	35	.	.	.
cord-001859-d62iuk72	228	1	(	(	-LRB-
cord-001859-d62iuk72	228	2	D	D	NNP
cord-001859-d62iuk72	228	3	)	)	-RRB-
cord-001859-d62iuk72	228	4	Cells	cell	NNS
cord-001859-d62iuk72	228	5	were	be	VBD
cord-001859-d62iuk72	228	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	228	7	for	for	IN
cord-001859-d62iuk72	228	8	24	24	CD
cord-001859-d62iuk72	228	9	h	h	NN
cord-001859-d62iuk72	228	10	to	to	TO
cord-001859-d62iuk72	228	11	allow	allow	VB
cord-001859-d62iuk72	228	12	robust	robust	JJ
cord-001859-d62iuk72	228	13	viral	viral	JJ
cord-001859-d62iuk72	228	14	protein	protein	NN
cord-001859-d62iuk72	228	15	expression	expression	NN
cord-001859-d62iuk72	228	16	.	.	.
cord-001859-d62iuk72	229	1	Then	then	RB
cord-001859-d62iuk72	229	2	,	,	,
cord-001859-d62iuk72	229	3	DMSO	DMSO	NNP
cord-001859-d62iuk72	229	4	control	control	NN
cord-001859-d62iuk72	229	5	(	(	-LRB-
cord-001859-d62iuk72	229	6	0.1	0.1	CD
cord-001859-d62iuk72	229	7	%	%	NN
cord-001859-d62iuk72	229	8	)	)	-RRB-
cord-001859-d62iuk72	229	9	or	or	CC
cord-001859-d62iuk72	229	10	VER-155008	ver-155008	NN
cord-001859-d62iuk72	229	11	was	be	VBD
cord-001859-d62iuk72	229	12	added	add	VBN
cord-001859-d62iuk72	229	13	in	in	IN
cord-001859-d62iuk72	229	14	conjunction	conjunction	NN
cord-001859-d62iuk72	229	15	with	with	IN
cord-001859-d62iuk72	229	16	cycloheximide	cycloheximide	NN
cord-001859-d62iuk72	229	17	(	(	-LRB-
cord-001859-d62iuk72	229	18	CHX	CHX	NNP
cord-001859-d62iuk72	229	19	)	)	-RRB-
cord-001859-d62iuk72	229	20	at	at	IN
cord-001859-d62iuk72	229	21	100	100	CD
cord-001859-d62iuk72	229	22	μg	μg	NNS
cord-001859-d62iuk72	229	23	/	/	SYM
cord-001859-d62iuk72	229	24	ml	ml	NN
cord-001859-d62iuk72	229	25	to	to	TO
cord-001859-d62iuk72	229	26	block	block	VB
cord-001859-d62iuk72	229	27	de	de	NNP
cord-001859-d62iuk72	229	28	novo	novo	NNP
cord-001859-d62iuk72	229	29	protein	protein	NNP
cord-001859-d62iuk72	229	30	synthesis	synthesis	NN
cord-001859-d62iuk72	229	31	.	.	.
cord-001859-d62iuk72	230	1	Protein	protein	NN
cord-001859-d62iuk72	230	2	lysates	lysate	NNS
cord-001859-d62iuk72	230	3	were	be	VBD
cord-001859-d62iuk72	230	4	collected	collect	VBN
cord-001859-d62iuk72	230	5	at	at	IN
cord-001859-d62iuk72	230	6	several	several	JJ
cord-001859-d62iuk72	230	7	times	time	NNS
cord-001859-d62iuk72	230	8	post	post	JJ
cord-001859-d62iuk72	230	9	-	-	JJ
cord-001859-d62iuk72	230	10	CHX	chx	JJ
cord-001859-d62iuk72	230	11	addition	addition	NN
cord-001859-d62iuk72	230	12	(	(	-LRB-
cord-001859-d62iuk72	230	13	0	0	CD
cord-001859-d62iuk72	230	14	,	,	,
cord-001859-d62iuk72	230	15	4	4	CD
cord-001859-d62iuk72	230	16	,	,	,
cord-001859-d62iuk72	230	17	8	8	CD
cord-001859-d62iuk72	230	18	,	,	,
cord-001859-d62iuk72	230	19	16	16	CD
cord-001859-d62iuk72	230	20	and	and	CC
cord-001859-d62iuk72	230	21	24	24	CD
cord-001859-d62iuk72	230	22	h	h	NN
cord-001859-d62iuk72	230	23	)	)	-RRB-
cord-001859-d62iuk72	230	24	and	and	CC
cord-001859-d62iuk72	230	25	Western	western	JJ
cord-001859-d62iuk72	230	26	blotting	blotting	NN
cord-001859-d62iuk72	230	27	was	be	VBD
cord-001859-d62iuk72	230	28	performed	perform	VBN
cord-001859-d62iuk72	230	29	.	.	.
cord-001859-d62iuk72	231	1	As	as	IN
cord-001859-d62iuk72	231	2	previously	previously	RB
cord-001859-d62iuk72	231	3	seen	see	VBN
cord-001859-d62iuk72	231	4	in	in	IN
cord-001859-d62iuk72	231	5	TREx	TREx	NNS
cord-001859-d62iuk72	231	6	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	231	7	cells	cell	NNS
cord-001859-d62iuk72	231	8	,	,	,
cord-001859-d62iuk72	231	9	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	231	10	did	do	VBD
cord-001859-d62iuk72	231	11	not	not	RB
cord-001859-d62iuk72	231	12	alter	alter	VB
cord-001859-d62iuk72	231	13	the	the	DT
cord-001859-d62iuk72	231	14	half	half	JJ
cord-001859-d62iuk72	231	15	-	-	HYPH
cord-001859-d62iuk72	231	16	life	life	NN
cord-001859-d62iuk72	231	17	of	of	IN
cord-001859-d62iuk72	231	18	RTA	RTA	NNP
cord-001859-d62iuk72	231	19	or	or	CC
cord-001859-d62iuk72	231	20	ORF57	ORF57	NNP
cord-001859-d62iuk72	231	21	protein	protein	NN
cord-001859-d62iuk72	231	22	.	.	.
cord-001859-d62iuk72	232	1	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	232	2	Isoforms	Isoforms	NNP
cord-001859-d62iuk72	232	3	Are	be	VBP
cord-001859-d62iuk72	232	4	Essential	essential	JJ
cord-001859-d62iuk72	232	5	for	for	IN
cord-001859-d62iuk72	232	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	232	7	Lytic	Lytic	NNP
cord-001859-d62iuk72	232	8	Replication	Replication	NNP
cord-001859-d62iuk72	232	9	Fig	Fig	NNP
cord-001859-d62iuk72	232	10	6A	6a	CD
cord-001859-d62iuk72	232	11	)	)	-RRB-
cord-001859-d62iuk72	232	12	.	.	.
cord-001859-d62iuk72	233	1	It	-PRON-	PRP
cord-001859-d62iuk72	233	2	is	be	VBZ
cord-001859-d62iuk72	233	3	intriguing	intriguing	JJ
cord-001859-d62iuk72	233	4	that	that	IN
cord-001859-d62iuk72	233	5	ORF57	ORF57	NNP
cord-001859-d62iuk72	233	6	mRNA	mRNA	NNP
cord-001859-d62iuk72	233	7	levels	level	NNS
cord-001859-d62iuk72	233	8	did	do	VBD
cord-001859-d62iuk72	233	9	not	not	RB
cord-001859-d62iuk72	233	10	show	show	VB
cord-001859-d62iuk72	233	11	a	a	DT
cord-001859-d62iuk72	233	12	clear	clear	JJ
cord-001859-d62iuk72	233	13	dose	dose	NN
cord-001859-d62iuk72	233	14	-	-	HYPH
cord-001859-d62iuk72	233	15	response	response	NN
cord-001859-d62iuk72	233	16	with	with	IN
cord-001859-d62iuk72	233	17	the	the	DT
cord-001859-d62iuk72	233	18	inhibitor	inhibitor	NN
cord-001859-d62iuk72	233	19	as	as	IN
cord-001859-d62iuk72	233	20	seen	see	VBN
cord-001859-d62iuk72	233	21	for	for	IN
cord-001859-d62iuk72	233	22	ORF57	ORF57	NNP
cord-001859-d62iuk72	234	1	mRNA	mRNA	NNP
cord-001859-d62iuk72	234	2	in	in	IN
cord-001859-d62iuk72	234	3	TREx	TREx	NNS
cord-001859-d62iuk72	234	4	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	234	5	cells	cell	NNS
cord-001859-d62iuk72	234	6	;	;	:
cord-001859-d62iuk72	234	7	however	however	RB
cord-001859-d62iuk72	234	8	the	the	DT
cord-001859-d62iuk72	234	9	levels	level	NNS
cord-001859-d62iuk72	234	10	were	be	VBD
cord-001859-d62iuk72	234	11	decreased	decrease	VBN
cord-001859-d62iuk72	234	12	compared	compare	VBN
cord-001859-d62iuk72	234	13	with	with	IN
cord-001859-d62iuk72	234	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	234	15	-	-	HYPH
cord-001859-d62iuk72	234	16	control	control	NN
cord-001859-d62iuk72	234	17	cells	cell	NNS
cord-001859-d62iuk72	234	18	.	.	.
cord-001859-d62iuk72	235	1	This	this	DT
cord-001859-d62iuk72	235	2	is	be	VBZ
cord-001859-d62iuk72	235	3	the	the	DT
cord-001859-d62iuk72	235	4	only	only	JJ
cord-001859-d62iuk72	235	5	transcript	transcript	NN
cord-001859-d62iuk72	235	6	of	of	IN
cord-001859-d62iuk72	235	7	all	all	PDT
cord-001859-d62iuk72	235	8	the	the	DT
cord-001859-d62iuk72	235	9	viral	viral	JJ
cord-001859-d62iuk72	235	10	transcripts	transcript	NNS
cord-001859-d62iuk72	235	11	tested	test	VBN
cord-001859-d62iuk72	235	12	in	in	IN
cord-001859-d62iuk72	235	13	both	both	DT
cord-001859-d62iuk72	235	14	cell	cell	NN
cord-001859-d62iuk72	235	15	lines	line	NNS
cord-001859-d62iuk72	235	16	that	that	WDT
cord-001859-d62iuk72	235	17	did	do	VBD
cord-001859-d62iuk72	235	18	not	not	RB
cord-001859-d62iuk72	235	19	show	show	VB
cord-001859-d62iuk72	235	20	a	a	DT
cord-001859-d62iuk72	235	21	dose	dose	NN
cord-001859-d62iuk72	235	22	-	-	HYPH
cord-001859-d62iuk72	235	23	response	response	NN
cord-001859-d62iuk72	235	24	.	.	.
cord-001859-d62iuk72	236	1	However	however	RB
cord-001859-d62iuk72	236	2	,	,	,
cord-001859-d62iuk72	236	3	Western	western	JJ
cord-001859-d62iuk72	236	4	blotting	blotting	NN
cord-001859-d62iuk72	236	5	did	do	VBD
cord-001859-d62iuk72	236	6	reveal	reveal	VB
cord-001859-d62iuk72	236	7	a	a	DT
cord-001859-d62iuk72	236	8	complete	complete	JJ
cord-001859-d62iuk72	236	9	reduction	reduction	NN
cord-001859-d62iuk72	236	10	of	of	IN
cord-001859-d62iuk72	236	11	ORF57	ORF57	NNP
cord-001859-d62iuk72	236	12	protein	protein	NN
cord-001859-d62iuk72	236	13	in	in	IN
cord-001859-d62iuk72	236	14	cells	cell	NNS
cord-001859-d62iuk72	236	15	treated	treat	VBN
cord-001859-d62iuk72	236	16	with	with	IN
cord-001859-d62iuk72	236	17	>	>	XX
cord-001859-d62iuk72	236	18	40	40	CD
cord-001859-d62iuk72	236	19	μM	μm	CD
cord-001859-d62iuk72	237	1	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	238	1	(	(	-LRB-
cord-001859-d62iuk72	238	2	Fig	Fig	NNP
cord-001859-d62iuk72	238	3	4C	4c	CD
cord-001859-d62iuk72	238	4	)	)	-RRB-
cord-001859-d62iuk72	238	5	.	.	.
cord-001859-d62iuk72	239	1	This	this	DT
cord-001859-d62iuk72	239	2	suggests	suggest	VBZ
cord-001859-d62iuk72	239	3	that	that	IN
cord-001859-d62iuk72	239	4	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	239	5	isoforms	isoform	NNS
cord-001859-d62iuk72	239	6	may	may	MD
cord-001859-d62iuk72	239	7	also	also	RB
cord-001859-d62iuk72	239	8	play	play	VB
cord-001859-d62iuk72	239	9	a	a	DT
cord-001859-d62iuk72	239	10	role	role	NN
cord-001859-d62iuk72	239	11	in	in	IN
cord-001859-d62iuk72	239	12	the	the	DT
cord-001859-d62iuk72	239	13	folding	folding	NN
cord-001859-d62iuk72	239	14	of	of	IN
cord-001859-d62iuk72	239	15	ORF57	ORF57	NNP
cord-001859-d62iuk72	239	16	protein	protein	NN
cord-001859-d62iuk72	239	17	.	.	.
cord-001859-d62iuk72	240	1	In	in	IN
cord-001859-d62iuk72	240	2	fact	fact	NN
cord-001859-d62iuk72	240	3	,	,	,
cord-001859-d62iuk72	240	4	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	240	5	has	have	VBZ
cord-001859-d62iuk72	240	6	been	be	VBN
cord-001859-d62iuk72	240	7	previously	previously	RB
cord-001859-d62iuk72	240	8	reported	report	VBN
cord-001859-d62iuk72	240	9	to	to	TO
cord-001859-d62iuk72	240	10	associate	associate	VB
cord-001859-d62iuk72	240	11	with	with	IN
cord-001859-d62iuk72	240	12	at	at	RB
cord-001859-d62iuk72	240	13	least	least	RBS
cord-001859-d62iuk72	240	14	15	15	CD
cord-001859-d62iuk72	240	15	-	-	SYM
cord-001859-d62iuk72	240	16	20	20	CD
cord-001859-d62iuk72	240	17	%	%	NN
cord-001859-d62iuk72	240	18	of	of	IN
cord-001859-d62iuk72	240	19	newly	newly	RB
cord-001859-d62iuk72	240	20	synthesized	synthesize	VBN
cord-001859-d62iuk72	240	21	proteins	protein	NNS
cord-001859-d62iuk72	240	22	during	during	IN
cord-001859-d62iuk72	240	23	their	-PRON-	PRP$
cord-001859-d62iuk72	240	24	biogenesis	biogenesis	NN
cord-001859-d62iuk72	240	25	[	[	-LRB-
cord-001859-d62iuk72	240	26	65	65	CD
cord-001859-d62iuk72	240	27	]	]	-RRB-
cord-001859-d62iuk72	240	28	,	,	,
cord-001859-d62iuk72	240	29	thus	thus	RB
cord-001859-d62iuk72	240	30	,	,	,
cord-001859-d62iuk72	240	31	a	a	DT
cord-001859-d62iuk72	240	32	role	role	NN
cord-001859-d62iuk72	240	33	for	for	IN
cord-001859-d62iuk72	240	34	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	240	35	isoforms	isoform	NNS
cord-001859-d62iuk72	240	36	in	in	IN
cord-001859-d62iuk72	240	37	folding	fold	VBG
cord-001859-d62iuk72	240	38	viral	viral	JJ
cord-001859-d62iuk72	240	39	proteins	protein	NNS
cord-001859-d62iuk72	240	40	can	can	MD
cord-001859-d62iuk72	240	41	not	not	RB
cord-001859-d62iuk72	240	42	be	be	VB
cord-001859-d62iuk72	240	43	ruled	rule	VBN
cord-001859-d62iuk72	240	44	out	out	RP
cord-001859-d62iuk72	240	45	.	.	.
cord-001859-d62iuk72	241	1	In	in	IN
cord-001859-d62iuk72	241	2	order	order	NN
cord-001859-d62iuk72	241	3	to	to	TO
cord-001859-d62iuk72	241	4	evaluate	evaluate	VB
cord-001859-d62iuk72	241	5	cellular	cellular	JJ
cord-001859-d62iuk72	241	6	transcription	transcription	NN
cord-001859-d62iuk72	241	7	activity	activity	NN
cord-001859-d62iuk72	241	8	in	in	IN
cord-001859-d62iuk72	241	9	the	the	DT
cord-001859-d62iuk72	241	10	presence	presence	NN
cord-001859-d62iuk72	241	11	of	of	IN
cord-001859-d62iuk72	241	12	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	241	13	,	,	,
cord-001859-d62iuk72	241	14	we	-PRON-	PRP
cord-001859-d62iuk72	241	15	first	first	RB
cord-001859-d62iuk72	241	16	determined	determine	VBD
cord-001859-d62iuk72	241	17	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	241	18	transcript	transcript	NN
cord-001859-d62iuk72	241	19	stability	stability	NN
cord-001859-d62iuk72	241	20	in	in	IN
cord-001859-d62iuk72	241	21	mRNA	mRNA	NNP
cord-001859-d62iuk72	241	22	decay	decay	NN
cord-001859-d62iuk72	241	23	assays	assay	NNS
cord-001859-d62iuk72	241	24	using	use	VBG
cord-001859-d62iuk72	241	25	AcD	acd	RB
cord-001859-d62iuk72	241	26	(	(	-LRB-
cord-001859-d62iuk72	241	27	10	10	CD
cord-001859-d62iuk72	241	28	μg	μg	NN
cord-001859-d62iuk72	241	29	/	/	SYM
cord-001859-d62iuk72	241	30	ml	ml	NNP
cord-001859-d62iuk72	241	31	)	)	-RRB-
cord-001859-d62iuk72	241	32	in	in	IN
cord-001859-d62iuk72	241	33	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	241	34	T	t	NN
cord-001859-d62iuk72	241	35	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	241	36	cells	cell	NNS
cord-001859-d62iuk72	241	37	.	.	.
cord-001859-d62iuk72	242	1	In	in	IN
cord-001859-d62iuk72	242	2	contrast	contrast	NN
cord-001859-d62iuk72	242	3	to	to	IN
cord-001859-d62iuk72	242	4	TREx	TREx	NNS
cord-001859-d62iuk72	242	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	242	6	cells	cell	NNS
cord-001859-d62iuk72	242	7	,	,	,
cord-001859-d62iuk72	242	8	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	242	9	transcripts	transcript	NNS
cord-001859-d62iuk72	242	10	were	be	VBD
cord-001859-d62iuk72	242	11	very	very	RB
cord-001859-d62iuk72	242	12	stable	stable	JJ
cord-001859-d62iuk72	242	13	,	,	,
cord-001859-d62iuk72	242	14	with	with	IN
cord-001859-d62iuk72	242	15	no	no	DT
cord-001859-d62iuk72	242	16	significant	significant	JJ
cord-001859-d62iuk72	242	17	reduction	reduction	NN
cord-001859-d62iuk72	242	18	in	in	IN
cord-001859-d62iuk72	242	19	their	-PRON-	PRP$
cord-001859-d62iuk72	242	20	levels	level	NNS
cord-001859-d62iuk72	242	21	after	after	IN
cord-001859-d62iuk72	242	22	10	10	CD
cord-001859-d62iuk72	242	23	h	h	NN
cord-001859-d62iuk72	242	24	of	of	IN
cord-001859-d62iuk72	242	25	AcD	acd	JJ
cord-001859-d62iuk72	242	26	treatment	treatment	NN
cord-001859-d62iuk72	242	27	(	(	-LRB-
cord-001859-d62iuk72	242	28	Fig	Fig	NNP
cord-001859-d62iuk72	242	29	6B	6b	CD
cord-001859-d62iuk72	242	30	)	)	-RRB-
cord-001859-d62iuk72	242	31	.	.	.
cord-001859-d62iuk72	243	1	The	the	DT
cord-001859-d62iuk72	243	2	half	half	RB
cord-001859-d62iuk72	243	3	-	-	HYPH
cord-001859-d62iuk72	243	4	lives	life	NNS
cord-001859-d62iuk72	243	5	of	of	IN
cord-001859-d62iuk72	243	6	two	two	CD
cord-001859-d62iuk72	243	7	cellular	cellular	JJ
cord-001859-d62iuk72	243	8	transcripts	transcript	NNS
cord-001859-d62iuk72	243	9	,	,	,
cord-001859-d62iuk72	243	10	SRAG	SRAG	NNP
cord-001859-d62iuk72	243	11	(	(	-LRB-
cord-001859-d62iuk72	243	12	a	a	DT
cord-001859-d62iuk72	243	13	cellular	cellular	JJ
cord-001859-d62iuk72	243	14	mRNA	mRNA	NNP
cord-001859-d62iuk72	243	15	export	export	NN
cord-001859-d62iuk72	243	16	adapter	adapter	NN
cord-001859-d62iuk72	243	17	)	)	-RRB-
cord-001859-d62iuk72	243	18	and	and	CC
cord-001859-d62iuk72	243	19	histone	histone	VBG
cord-001859-d62iuk72	243	20	H2A	h2a	CD
cord-001859-d62iuk72	243	21	(	(	-LRB-
cord-001859-d62iuk72	243	22	H2A.1	H2A.1	NNP
cord-001859-d62iuk72	243	23	)	)	-RRB-
cord-001859-d62iuk72	243	24	were	be	VBD
cord-001859-d62iuk72	243	25	also	also	RB
cord-001859-d62iuk72	243	26	determined	determine	VBN
cord-001859-d62iuk72	243	27	in	in	IN
cord-001859-d62iuk72	243	28	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	243	29	T	t	NN
cord-001859-d62iuk72	243	30	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	243	31	cells	cell	NNS
cord-001859-d62iuk72	243	32	.	.	.
cord-001859-d62iuk72	244	1	SRAG	SRAG	NNP
cord-001859-d62iuk72	244	2	transcripts	transcript	NNS
cord-001859-d62iuk72	244	3	were	be	VBD
cord-001859-d62iuk72	244	4	reduced	reduce	VBN
cord-001859-d62iuk72	244	5	to	to	IN
cord-001859-d62iuk72	244	6	50	50	CD
cord-001859-d62iuk72	244	7	%	%	NN
cord-001859-d62iuk72	244	8	following	follow	VBG
cord-001859-d62iuk72	244	9	4	4	CD
cord-001859-d62iuk72	244	10	h	h	NN
cord-001859-d62iuk72	244	11	AcD	acd	JJ
cord-001859-d62iuk72	244	12	treatment	treatment	NN
cord-001859-d62iuk72	244	13	(	(	-LRB-
cord-001859-d62iuk72	244	14	Fig	Fig	NNP
cord-001859-d62iuk72	244	15	6C	6C	NNP
cord-001859-d62iuk72	244	16	)	)	-RRB-
cord-001859-d62iuk72	244	17	,	,	,
cord-001859-d62iuk72	244	18	while	while	IN
cord-001859-d62iuk72	244	19	the	the	DT
cord-001859-d62iuk72	244	20	H2A.1	H2A.1	NNP
cord-001859-d62iuk72	244	21	mRNA	mrna	NN
cord-001859-d62iuk72	244	22	was	be	VBD
cord-001859-d62iuk72	244	23	very	very	RB
cord-001859-d62iuk72	244	24	unstable	unstable	JJ
cord-001859-d62iuk72	244	25	with	with	IN
cord-001859-d62iuk72	244	26	nearly	nearly	RB
cord-001859-d62iuk72	244	27	100	100	CD
cord-001859-d62iuk72	244	28	%	%	NN
cord-001859-d62iuk72	244	29	reduction	reduction	NN
cord-001859-d62iuk72	244	30	after	after	IN
cord-001859-d62iuk72	244	31	2	2	CD
cord-001859-d62iuk72	244	32	h	h	NN
cord-001859-d62iuk72	244	33	AcD	acd	NN
cord-001859-d62iuk72	244	34	treatment	treatment	NN
cord-001859-d62iuk72	244	35	(	(	-LRB-
cord-001859-d62iuk72	244	36	Fig	Fig	NNP
cord-001859-d62iuk72	244	37	6D	6d	NN
cord-001859-d62iuk72	244	38	)	)	-RRB-
cord-001859-d62iuk72	244	39	.	.	.
cord-001859-d62iuk72	245	1	We	-PRON-	PRP
cord-001859-d62iuk72	245	2	then	then	RB
cord-001859-d62iuk72	245	3	plotted	plot	VBD
cord-001859-d62iuk72	245	4	the	the	DT
cord-001859-d62iuk72	245	5	raw	raw	JJ
cord-001859-d62iuk72	245	6	C	c	NN
cord-001859-d62iuk72	245	7	T	t	NN
cord-001859-d62iuk72	245	8	values	value	NNS
cord-001859-d62iuk72	245	9	for	for	IN
cord-001859-d62iuk72	245	10	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	245	11	transcript	transcript	NN
cord-001859-d62iuk72	245	12	from	from	IN
cord-001859-d62iuk72	245	13	samples	sample	NNS
cord-001859-d62iuk72	245	14	in	in	IN
cord-001859-d62iuk72	245	15	which	which	WDT
cord-001859-d62iuk72	245	16	viral	viral	JJ
cord-001859-d62iuk72	245	17	transcripts	transcript	NNS
cord-001859-d62iuk72	245	18	had	have	VBD
cord-001859-d62iuk72	245	19	been	be	VBN
cord-001859-d62iuk72	245	20	quantified	quantify	VBN
cord-001859-d62iuk72	245	21	after	after	IN
cord-001859-d62iuk72	245	22	24	24	CD
cord-001859-d62iuk72	245	23	h	h	NN
cord-001859-d62iuk72	245	24	of	of	IN
cord-001859-d62iuk72	245	25	VER-155008	ver-155008	JJ
cord-001859-d62iuk72	245	26	treatment	treatment	NN
cord-001859-d62iuk72	245	27	;	;	:
cord-001859-d62iuk72	245	28	these	these	DT
cord-001859-d62iuk72	245	29	did	do	VBD
cord-001859-d62iuk72	245	30	not	not	RB
cord-001859-d62iuk72	245	31	significantly	significantly	RB
cord-001859-d62iuk72	245	32	change	change	VB
cord-001859-d62iuk72	245	33	in	in	IN
cord-001859-d62iuk72	245	34	the	the	DT
cord-001859-d62iuk72	245	35	presence	presence	NN
cord-001859-d62iuk72	245	36	of	of	IN
cord-001859-d62iuk72	245	37	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	245	38	(	(	-LRB-
cord-001859-d62iuk72	245	39	Fig	Fig	NNP
cord-001859-d62iuk72	245	40	6E	6E	NNP
cord-001859-d62iuk72	245	41	)	)	-RRB-
cord-001859-d62iuk72	245	42	.	.	.
cord-001859-d62iuk72	246	1	Next	next	RB
cord-001859-d62iuk72	246	2	,	,	,
cord-001859-d62iuk72	246	3	the	the	DT
cord-001859-d62iuk72	246	4	unstable	unstable	JJ
cord-001859-d62iuk72	246	5	SRAG	SRAG	NNP
cord-001859-d62iuk72	246	6	and	and	CC
cord-001859-d62iuk72	246	7	H2A.1	h2a.1	NN
cord-001859-d62iuk72	246	8	mRNAs	mRNAs	NNPS
cord-001859-d62iuk72	246	9	were	be	VBD
cord-001859-d62iuk72	246	10	measured	measure	VBN
cord-001859-d62iuk72	246	11	in	in	IN
cord-001859-d62iuk72	246	12	the	the	DT
cord-001859-d62iuk72	246	13	same	same	JJ
cord-001859-d62iuk72	246	14	samples	sample	NNS
cord-001859-d62iuk72	246	15	in	in	IN
cord-001859-d62iuk72	246	16	which	which	WDT
cord-001859-d62iuk72	246	17	viral	viral	JJ
cord-001859-d62iuk72	246	18	transcripts	transcript	NNS
cord-001859-d62iuk72	246	19	had	have	VBD
cord-001859-d62iuk72	246	20	been	be	VBN
cord-001859-d62iuk72	246	21	quantified	quantify	VBN
cord-001859-d62iuk72	246	22	after	after	IN
cord-001859-d62iuk72	246	23	24	24	CD
cord-001859-d62iuk72	246	24	h	h	NN
cord-001859-d62iuk72	246	25	of	of	IN
cord-001859-d62iuk72	246	26	VER-155008	ver-155008	JJ
cord-001859-d62iuk72	246	27	treatment	treatment	NN
cord-001859-d62iuk72	246	28	.	.	.
cord-001859-d62iuk72	247	1	In	in	IN
cord-001859-d62iuk72	247	2	contrast	contrast	NN
cord-001859-d62iuk72	247	3	to	to	IN
cord-001859-d62iuk72	247	4	viral	viral	JJ
cord-001859-d62iuk72	247	5	transcripts	transcript	NNS
cord-001859-d62iuk72	247	6	,	,	,
cord-001859-d62iuk72	247	7	both	both	DT
cord-001859-d62iuk72	247	8	cellular	cellular	JJ
cord-001859-d62iuk72	247	9	transcripts	transcript	NNS
cord-001859-d62iuk72	247	10	were	be	VBD
cord-001859-d62iuk72	247	11	not	not	RB
cord-001859-d62iuk72	247	12	significantly	significantly	RB
cord-001859-d62iuk72	247	13	reduced	reduce	VBN
cord-001859-d62iuk72	247	14	,	,	,
cord-001859-d62iuk72	247	15	indicating	indicate	VBG
cord-001859-d62iuk72	247	16	that	that	IN
cord-001859-d62iuk72	247	17	transcription	transcription	NN
cord-001859-d62iuk72	247	18	of	of	IN
cord-001859-d62iuk72	247	19	cellular	cellular	JJ
cord-001859-d62iuk72	247	20	genes	gene	NNS
cord-001859-d62iuk72	247	21	was	be	VBD
cord-001859-d62iuk72	247	22	occurring	occur	VBG
cord-001859-d62iuk72	247	23	normally	normally	RB
cord-001859-d62iuk72	247	24	even	even	RB
cord-001859-d62iuk72	247	25	in	in	IN
cord-001859-d62iuk72	247	26	the	the	DT
cord-001859-d62iuk72	247	27	presence	presence	NN
cord-001859-d62iuk72	247	28	of	of	IN
cord-001859-d62iuk72	247	29	high	high	JJ
cord-001859-d62iuk72	247	30	VER-155008	ver-155008	NN
cord-001859-d62iuk72	247	31	concentrations	concentration	NNS
cord-001859-d62iuk72	247	32	(	(	-LRB-
cord-001859-d62iuk72	247	33	Fig	Fig	NNP
cord-001859-d62iuk72	247	34	6F	6f	NN
cord-001859-d62iuk72	247	35	)	)	-RRB-
cord-001859-d62iuk72	247	36	.	.	.
cord-001859-d62iuk72	248	1	Taken	take	VBN
cord-001859-d62iuk72	248	2	together	together	RB
cord-001859-d62iuk72	248	3	,	,	,
cord-001859-d62iuk72	248	4	these	these	DT
cord-001859-d62iuk72	248	5	results	result	NNS
cord-001859-d62iuk72	248	6	demonstrate	demonstrate	VBP
cord-001859-d62iuk72	248	7	that	that	IN
cord-001859-d62iuk72	248	8	inhibition	inhibition	NN
cord-001859-d62iuk72	248	9	of	of	IN
cord-001859-d62iuk72	248	10	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	248	11	isoform	isoform	NN
cord-001859-d62iuk72	248	12	function	function	NN
cord-001859-d62iuk72	248	13	abrogated	abrogate	VBD
cord-001859-d62iuk72	248	14	the	the	DT
cord-001859-d62iuk72	248	15	expression	expression	NN
cord-001859-d62iuk72	248	16	of	of	IN
cord-001859-d62iuk72	248	17	viral	viral	JJ
cord-001859-d62iuk72	248	18	genes	gene	NNS
cord-001859-d62iuk72	248	19	from	from	IN
cord-001859-d62iuk72	248	20	various	various	JJ
cord-001859-d62iuk72	248	21	temporal	temporal	JJ
cord-001859-d62iuk72	248	22	classes	class	NNS
cord-001859-d62iuk72	248	23	;	;	:
cord-001859-d62iuk72	248	24	however	however	RB
cord-001859-d62iuk72	248	25	cellular	cellular	JJ
cord-001859-d62iuk72	248	26	RNA	RNA	NNP
cord-001859-d62iuk72	248	27	-	-	HYPH
cord-001859-d62iuk72	248	28	PII	PII	NNP
cord-001859-d62iuk72	248	29	-	-	HYPH
cord-001859-d62iuk72	248	30	mediated	mediate	VBN
cord-001859-d62iuk72	248	31	transcription	transcription	NN
cord-001859-d62iuk72	248	32	was	be	VBD
cord-001859-d62iuk72	248	33	not	not	RB
cord-001859-d62iuk72	248	34	compromised	compromise	VBN
cord-001859-d62iuk72	248	35	when	when	WRB
cord-001859-d62iuk72	248	36	using	use	VBG
cord-001859-d62iuk72	248	37	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	248	38	at	at	IN
cord-001859-d62iuk72	248	39	non	non	JJ
cord-001859-d62iuk72	248	40	-	-	JJ
cord-001859-d62iuk72	248	41	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	248	42	concentrations	concentration	NNS
cord-001859-d62iuk72	248	43	.	.	.
cord-001859-d62iuk72	249	1	Following	follow	VBG
cord-001859-d62iuk72	249	2	quantification	quantification	NN
cord-001859-d62iuk72	249	3	of	of	IN
cord-001859-d62iuk72	249	4	viral	viral	JJ
cord-001859-d62iuk72	249	5	transcripts	transcript	NNS
cord-001859-d62iuk72	249	6	in	in	IN
cord-001859-d62iuk72	249	7	both	both	DT
cord-001859-d62iuk72	249	8	cell	cell	NN
cord-001859-d62iuk72	249	9	lines	line	NNS
cord-001859-d62iuk72	249	10	,	,	,
cord-001859-d62iuk72	249	11	it	-PRON-	PRP
cord-001859-d62iuk72	249	12	appeared	appear	VBD
cord-001859-d62iuk72	249	13	that	that	IN
cord-001859-d62iuk72	249	14	the	the	DT
cord-001859-d62iuk72	249	15	reduction	reduction	NN
cord-001859-d62iuk72	249	16	seen	see	VBN
cord-001859-d62iuk72	249	17	in	in	IN
cord-001859-d62iuk72	249	18	viral	viral	JJ
cord-001859-d62iuk72	249	19	gene	gene	NN
cord-001859-d62iuk72	249	20	expression	expression	NN
cord-001859-d62iuk72	249	21	,	,	,
cord-001859-d62iuk72	249	22	protein	protein	NN
cord-001859-d62iuk72	249	23	production	production	NN
cord-001859-d62iuk72	249	24	and	and	CC
cord-001859-d62iuk72	249	25	infectious	infectious	JJ
cord-001859-d62iuk72	249	26	virion	virion	NN
cord-001859-d62iuk72	249	27	production	production	NN
cord-001859-d62iuk72	249	28	could	could	MD
cord-001859-d62iuk72	249	29	be	be	VB
cord-001859-d62iuk72	249	30	a	a	DT
cord-001859-d62iuk72	249	31	consequence	consequence	NN
cord-001859-d62iuk72	249	32	of	of	IN
cord-001859-d62iuk72	249	33	a	a	DT
cord-001859-d62iuk72	249	34	significant	significant	JJ
cord-001859-d62iuk72	249	35	global	global	JJ
cord-001859-d62iuk72	249	36	reduction	reduction	NN
cord-001859-d62iuk72	249	37	of	of	IN
cord-001859-d62iuk72	249	38	viral	viral	JJ
cord-001859-d62iuk72	249	39	transcripts	transcript	NNS
cord-001859-d62iuk72	249	40	in	in	IN
cord-001859-d62iuk72	249	41	inhibitor	inhibitor	NN
cord-001859-d62iuk72	249	42	-	-	HYPH
cord-001859-d62iuk72	249	43	treated	treat	VBN
cord-001859-d62iuk72	249	44	cells	cell	NNS
cord-001859-d62iuk72	249	45	.	.	.
cord-001859-d62iuk72	250	1	This	this	DT
cord-001859-d62iuk72	250	2	led	lead	VBD
cord-001859-d62iuk72	250	3	to	to	IN
cord-001859-d62iuk72	250	4	the	the	DT
cord-001859-d62iuk72	250	5	possibility	possibility	NN
cord-001859-d62iuk72	250	6	that	that	IN
cord-001859-d62iuk72	250	7	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	250	8	isoforms	isoform	NNS
cord-001859-d62iuk72	250	9	could	could	MD
cord-001859-d62iuk72	250	10	be	be	VB
cord-001859-d62iuk72	250	11	implicated	implicate	VBN
cord-001859-d62iuk72	250	12	in	in	IN
cord-001859-d62iuk72	250	13	activation	activation	NN
cord-001859-d62iuk72	250	14	of	of	IN
cord-001859-d62iuk72	250	15	viral	viral	JJ
cord-001859-d62iuk72	250	16	promoters	promoter	NNS
cord-001859-d62iuk72	250	17	and	and	CC
cord-001859-d62iuk72	250	18	subsequent	subsequent	JJ
cord-001859-d62iuk72	250	19	transcription	transcription	NN
cord-001859-d62iuk72	250	20	or	or	CC
cord-001859-d62iuk72	250	21	alternatively	alternatively	RB
cord-001859-d62iuk72	250	22	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	250	23	isoforms	isoform	NNS
cord-001859-d62iuk72	250	24	were	be	VBD
cord-001859-d62iuk72	250	25	required	require	VBN
cord-001859-d62iuk72	250	26	for	for	IN
cord-001859-d62iuk72	250	27	KSHV	KSHV	NNP
cord-001859-d62iuk72	250	28	RTC	RTC	NNP
cord-001859-d62iuk72	250	29	formation	formation	NN
cord-001859-d62iuk72	250	30	.	.	.
cord-001859-d62iuk72	251	1	Because	because	IN
cord-001859-d62iuk72	251	2	viral	viral	JJ
cord-001859-d62iuk72	251	3	RTA	RTA	NNP
cord-001859-d62iuk72	251	4	and	and	CC
cord-001859-d62iuk72	251	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	251	6	co	co	VBD
cord-001859-d62iuk72	251	7	-	-	VBD
cord-001859-d62iuk72	251	8	localized	localize	VBN
cord-001859-d62iuk72	251	9	in	in	IN
cord-001859-d62iuk72	251	10	TREx	TREx	NNS
cord-001859-d62iuk72	251	11	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	251	12	cells	cell	NNS
cord-001859-d62iuk72	251	13	and	and	CC
cord-001859-d62iuk72	251	14	RTA	RTA	NNP
cord-001859-d62iuk72	251	15	is	be	VBZ
cord-001859-d62iuk72	251	16	(	(	-LRB-
cord-001859-d62iuk72	251	17	orange	orange	NNP
cord-001859-d62iuk72	251	18	colour	colour	NN
cord-001859-d62iuk72	251	19	)	)	-RRB-
cord-001859-d62iuk72	251	20	,	,	,
cord-001859-d62iuk72	251	21	late	late	JJ
cord-001859-d62iuk72	251	22	(	(	-LRB-
cord-001859-d62iuk72	251	23	red	red	JJ
cord-001859-d62iuk72	251	24	colour	colour	NN
cord-001859-d62iuk72	251	25	)	)	-RRB-
cord-001859-d62iuk72	251	26	and	and	CC
cord-001859-d62iuk72	251	27	ori	ori	NNP
cord-001859-d62iuk72	251	28	-	-	HYPH
cord-001859-d62iuk72	251	29	Lyt	lyt	JJ
cord-001859-d62iuk72	251	30	viral	viral	JJ
cord-001859-d62iuk72	251	31	transcripts	transcript	NNS
cord-001859-d62iuk72	251	32	were	be	VBD
cord-001859-d62iuk72	251	33	all	all	DT
cord-001859-d62iuk72	251	34	significantly	significantly	RB
cord-001859-d62iuk72	251	35	reduced	reduce	VBN
cord-001859-d62iuk72	251	36	at	at	IN
cord-001859-d62iuk72	251	37	1	1	CD
cord-001859-d62iuk72	251	38	μM	μm	CD
cord-001859-d62iuk72	251	39	VER-155008	VER-155008	NNS
cord-001859-d62iuk72	251	40	compared	compare	VBN
cord-001859-d62iuk72	251	41	to	to	IN
cord-001859-d62iuk72	251	42	the	the	DT
cord-001859-d62iuk72	251	43	levels	level	NNS
cord-001859-d62iuk72	251	44	found	find	VBN
cord-001859-d62iuk72	251	45	in	in	IN
cord-001859-d62iuk72	251	46	DMSOtreated	dmsotreated	JJ
cord-001859-d62iuk72	251	47	samples	sample	NNS
cord-001859-d62iuk72	251	48	.	.	.
cord-001859-d62iuk72	252	1	All	all	DT
cord-001859-d62iuk72	252	2	samples	sample	NNS
cord-001859-d62iuk72	252	3	were	be	VBD
cord-001859-d62iuk72	252	4	normalised	normalise	VBN
cord-001859-d62iuk72	252	5	to	to	IN
cord-001859-d62iuk72	252	6	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	252	7	.	.	.
cord-001859-d62iuk72	253	1	Results	result	NNS
cord-001859-d62iuk72	253	2	show	show	VBP
cord-001859-d62iuk72	253	3	the	the	DT
cord-001859-d62iuk72	253	4	mean	mean	NN
cord-001859-d62iuk72	253	5	of	of	IN
cord-001859-d62iuk72	253	6	three	three	CD
cord-001859-d62iuk72	253	7	biological	biological	JJ
cord-001859-d62iuk72	253	8	replicates	replicate	NNS
cord-001859-d62iuk72	253	9	with	with	IN
cord-001859-d62iuk72	253	10	error	error	NN
cord-001859-d62iuk72	253	11	bar	bar	NN
cord-001859-d62iuk72	253	12	as	as	IN
cord-001859-d62iuk72	253	13	standard	standard	JJ
cord-001859-d62iuk72	253	14	deviation	deviation	NN
cord-001859-d62iuk72	253	15	.	.	.
cord-001859-d62iuk72	254	1	(	(	-LRB-
cord-001859-d62iuk72	254	2	B	b	NN
cord-001859-d62iuk72	254	3	)	)	-RRB-
cord-001859-d62iuk72	255	1	The	the	DT
cord-001859-d62iuk72	255	2	stability	stability	NN
cord-001859-d62iuk72	255	3	of	of	IN
cord-001859-d62iuk72	255	4	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	255	5	transcript	transcript	NN
cord-001859-d62iuk72	255	6	was	be	VBD
cord-001859-d62iuk72	255	7	assessed	assess	VBN
cord-001859-d62iuk72	255	8	in	in	IN
cord-001859-d62iuk72	255	9	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	255	10	TREx	TREx	NNS
cord-001859-d62iuk72	255	11	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	255	12	cells	cell	NNS
cord-001859-d62iuk72	255	13	in	in	IN
cord-001859-d62iuk72	255	14	the	the	DT
cord-001859-d62iuk72	255	15	presence	presence	NN
cord-001859-d62iuk72	255	16	of	of	IN
cord-001859-d62iuk72	255	17	the	the	DT
cord-001859-d62iuk72	255	18	transcriptional	transcriptional	JJ
cord-001859-d62iuk72	255	19	inhibitor	inhibitor	NN
cord-001859-d62iuk72	255	20	actinomycin	actinomycin	NNS
cord-001859-d62iuk72	255	21	D	D	NNP
cord-001859-d62iuk72	255	22	(	(	-LRB-
cord-001859-d62iuk72	255	23	AcD	AcD	NNP
cord-001859-d62iuk72	255	24	)	)	-RRB-
cord-001859-d62iuk72	255	25	(	(	-LRB-
cord-001859-d62iuk72	255	26	2.5	2.5	CD
cord-001859-d62iuk72	255	27	μg	μg	NNS
cord-001859-d62iuk72	255	28	/	/	SYM
cord-001859-d62iuk72	255	29	ml	ml	NN
cord-001859-d62iuk72	255	30	)	)	-RRB-
cord-001859-d62iuk72	255	31	or	or	CC
cord-001859-d62iuk72	255	32	control	control	VB
cord-001859-d62iuk72	255	33	DMSO	DMSO	NNP
cord-001859-d62iuk72	255	34	(	(	-LRB-
cord-001859-d62iuk72	255	35	0.25	0.25	CD
cord-001859-d62iuk72	255	36	%	%	NN
cord-001859-d62iuk72	255	37	)	)	-RRB-
cord-001859-d62iuk72	255	38	.	.	.
cord-001859-d62iuk72	256	1	Cells	cell	NNS
cord-001859-d62iuk72	256	2	were	be	VBD
cord-001859-d62iuk72	256	3	collected	collect	VBN
cord-001859-d62iuk72	256	4	over	over	IN
cord-001859-d62iuk72	256	5	the	the	DT
cord-001859-d62iuk72	256	6	time	time	NN
cord-001859-d62iuk72	256	7	points	point	NNS
cord-001859-d62iuk72	256	8	indicated	indicate	VBN
cord-001859-d62iuk72	256	9	and	and	CC
cord-001859-d62iuk72	256	10	total	total	JJ
cord-001859-d62iuk72	256	11	RNA	RNA	NNP
cord-001859-d62iuk72	256	12	was	be	VBD
cord-001859-d62iuk72	256	13	extracted	extract	VBN
cord-001859-d62iuk72	256	14	followed	follow	VBN
cord-001859-d62iuk72	256	15	by	by	IN
cord-001859-d62iuk72	256	16	qRT	qRT	NNP
cord-001859-d62iuk72	256	17	-	-	HYPH
cord-001859-d62iuk72	256	18	PCR	PCR	NNP
cord-001859-d62iuk72	256	19	.	.	.
cord-001859-d62iuk72	257	1	After	after	IN
cord-001859-d62iuk72	257	2	6	6	CD
cord-001859-d62iuk72	257	3	h	h	NN
cord-001859-d62iuk72	257	4	AcD	acd	JJ
cord-001859-d62iuk72	257	5	treatment	treatment	NN
cord-001859-d62iuk72	257	6	,	,	,
cord-001859-d62iuk72	257	7	the	the	DT
cord-001859-d62iuk72	257	8	amount	amount	NN
cord-001859-d62iuk72	257	9	of	of	IN
cord-001859-d62iuk72	257	10	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	257	11	transcripts	transcript	NNS
cord-001859-d62iuk72	257	12	was	be	VBD
cord-001859-d62iuk72	257	13	reduced	reduce	VBN
cord-001859-d62iuk72	257	14	by	by	IN
cord-001859-d62iuk72	257	15	more	more	JJR
cord-001859-d62iuk72	257	16	than	than	IN
cord-001859-d62iuk72	257	17	half	half	PDT
cord-001859-d62iuk72	257	18	(	(	-LRB-
cord-001859-d62iuk72	257	19	C	c	NN
cord-001859-d62iuk72	257	20	T	t	NN
cord-001859-d62iuk72	257	21	=	=	NN
cord-001859-d62iuk72	257	22	18.09	18.09	CD
cord-001859-d62iuk72	257	23	)	)	-RRB-
cord-001859-d62iuk72	257	24	compared	compare	VBN
cord-001859-d62iuk72	257	25	with	with	IN
cord-001859-d62iuk72	257	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	257	27	-	-	HYPH
cord-001859-d62iuk72	257	28	treated	treat	VBN
cord-001859-d62iuk72	257	29	cells	cell	NNS
cord-001859-d62iuk72	257	30	(	(	-LRB-
cord-001859-d62iuk72	257	31	C	c	NN
cord-001859-d62iuk72	257	32	T	t	NN
cord-001859-d62iuk72	257	33	=	=	SYM
cord-001859-d62iuk72	257	34	16.24	16.24	CD
cord-001859-d62iuk72	257	35	)	)	-RRB-
cord-001859-d62iuk72	257	36	.	.	.
cord-001859-d62iuk72	258	1	A	a	DT
cord-001859-d62iuk72	258	2	further	further	JJ
cord-001859-d62iuk72	258	3	reduction	reduction	NN
cord-001859-d62iuk72	258	4	was	be	VBD
cord-001859-d62iuk72	258	5	observed	observe	VBN
cord-001859-d62iuk72	258	6	at	at	IN
cord-001859-d62iuk72	258	7	8	8	CD
cord-001859-d62iuk72	258	8	h	h	NN
cord-001859-d62iuk72	258	9	treatment	treatment	NN
cord-001859-d62iuk72	258	10	(	(	-LRB-
cord-001859-d62iuk72	258	11	C	C	NNP
cord-001859-d62iuk72	258	12	T	t	NN
cord-001859-d62iuk72	258	13	=	=	NN
cord-001859-d62iuk72	258	14	19.68	19.68	CD
cord-001859-d62iuk72	258	15	)	)	-RRB-
cord-001859-d62iuk72	258	16	.	.	.
cord-001859-d62iuk72	259	1	The	the	DT
cord-001859-d62iuk72	259	2	average	average	NN
cord-001859-d62iuk72	259	3	of	of	IN
cord-001859-d62iuk72	259	4	two	two	CD
cord-001859-d62iuk72	259	5	biological	biological	JJ
cord-001859-d62iuk72	259	6	replicates	replicate	NNS
cord-001859-d62iuk72	259	7	with	with	IN
cord-001859-d62iuk72	259	8	error	error	NN
cord-001859-d62iuk72	259	9	bar	bar	NN
cord-001859-d62iuk72	259	10	as	as	IN
cord-001859-d62iuk72	259	11	standard	standard	JJ
cord-001859-d62iuk72	259	12	deviation	deviation	NN
cord-001859-d62iuk72	259	13	is	be	VBZ
cord-001859-d62iuk72	259	14	shown	show	VBN
cord-001859-d62iuk72	259	15	.	.	.
cord-001859-d62iuk72	260	1	(	(	-LRB-
cord-001859-d62iuk72	260	2	C	C	NNP
cord-001859-d62iuk72	260	3	)	)	-RRB-
cord-001859-d62iuk72	261	1	The	the	DT
cord-001859-d62iuk72	261	2	amount	amount	NN
cord-001859-d62iuk72	261	3	of	of	IN
cord-001859-d62iuk72	261	4	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	261	5	transcripts	transcript	NNS
cord-001859-d62iuk72	261	6	did	do	VBD
cord-001859-d62iuk72	261	7	not	not	RB
cord-001859-d62iuk72	261	8	significantly	significantly	RB
cord-001859-d62iuk72	261	9	decrease	decrease	VB
cord-001859-d62iuk72	261	10	when	when	WRB
cord-001859-d62iuk72	261	11	using	use	VBG
cord-001859-d62iuk72	261	12	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	261	13	for	for	IN
cord-001859-d62iuk72	261	14	24	24	CD
cord-001859-d62iuk72	261	15	h	h	NN
cord-001859-d62iuk72	261	16	at	at	IN
cord-001859-d62iuk72	261	17	concentrations	concentration	NNS
cord-001859-d62iuk72	261	18	lower	low	JJR
cord-001859-d62iuk72	261	19	than	than	IN
cord-001859-d62iuk72	261	20	3	3	CD
cord-001859-d62iuk72	261	21	μM	μm	NN
cord-001859-d62iuk72	261	22	compared	compare	VBN
cord-001859-d62iuk72	261	23	to	to	IN
cord-001859-d62iuk72	261	24	DMSO	DMSO	NNP
cord-001859-d62iuk72	261	25	-	-	HYPH
cord-001859-d62iuk72	261	26	treated	treat	VBN
cord-001859-d62iuk72	261	27	samples	sample	NNS
cord-001859-d62iuk72	261	28	.	.	.
cord-001859-d62iuk72	262	1	In	in	IN
cord-001859-d62iuk72	262	2	contrast	contrast	NN
cord-001859-d62iuk72	262	3	,	,	,
cord-001859-d62iuk72	262	4	concentrations	concentration	NNS
cord-001859-d62iuk72	262	5	higher	high	JJR
cord-001859-d62iuk72	262	6	than	than	IN
cord-001859-d62iuk72	262	7	3	3	CD
cord-001859-d62iuk72	262	8	μM	μm	NN
cord-001859-d62iuk72	262	9	significantly	significantly	RB
cord-001859-d62iuk72	262	10	showed	show	VBD
cord-001859-d62iuk72	262	11	a	a	DT
cord-001859-d62iuk72	262	12	C	c	NN
cord-001859-d62iuk72	262	13	T	t	NN
cord-001859-d62iuk72	262	14	lower	low	JJR
cord-001859-d62iuk72	262	15	than	than	IN
cord-001859-d62iuk72	262	16	DMSO	DMSO	NNP
cord-001859-d62iuk72	262	17	samples	sample	NNS
cord-001859-d62iuk72	262	18	,	,	,
cord-001859-d62iuk72	262	19	indicating	indicate	VBG
cord-001859-d62iuk72	262	20	compromised	compromise	VBN
cord-001859-d62iuk72	262	21	cellular	cellular	JJ
cord-001859-d62iuk72	262	22	transcription	transcription	NN
cord-001859-d62iuk72	262	23	at	at	IN
cord-001859-d62iuk72	262	24	these	these	DT
cord-001859-d62iuk72	262	25	inhibitor	inhibitor	NN
cord-001859-d62iuk72	262	26	concentrations	concentration	NNS
cord-001859-d62iuk72	262	27	.	.	.
cord-001859-d62iuk72	263	1	The	the	DT
cord-001859-d62iuk72	263	2	same	same	JJ
cord-001859-d62iuk72	263	3	samples	sample	NNS
cord-001859-d62iuk72	263	4	in	in	IN
cord-001859-d62iuk72	263	5	which	which	WDT
cord-001859-d62iuk72	263	6	viral	viral	JJ
cord-001859-d62iuk72	263	7	transcripts	transcript	NNS
cord-001859-d62iuk72	263	8	had	have	VBD
cord-001859-d62iuk72	263	9	been	be	VBN
cord-001859-d62iuk72	263	10	quantified	quantify	VBN
cord-001859-d62iuk72	263	11	were	be	VBD
cord-001859-d62iuk72	263	12	used	use	VBN
cord-001859-d62iuk72	263	13	to	to	TO
cord-001859-d62iuk72	263	14	plot	plot	VB
cord-001859-d62iuk72	263	15	all	all	DT
cord-001859-d62iuk72	263	16	C	c	NN
cord-001859-d62iuk72	263	17	T	t	NN
cord-001859-d62iuk72	263	18	values	value	NNS
cord-001859-d62iuk72	263	19	.	.	.
cord-001859-d62iuk72	264	1	Results	result	NNS
cord-001859-d62iuk72	264	2	show	show	VBP
cord-001859-d62iuk72	264	3	the	the	DT
cord-001859-d62iuk72	264	4	mean	mean	NN
cord-001859-d62iuk72	264	5	of	of	IN
cord-001859-d62iuk72	264	6	three	three	CD
cord-001859-d62iuk72	264	7	biological	biological	JJ
cord-001859-d62iuk72	264	8	replicates	replicate	NNS
cord-001859-d62iuk72	264	9	with	with	IN
cord-001859-d62iuk72	264	10	error	error	NN
cord-001859-d62iuk72	264	11	bar	bar	NN
cord-001859-d62iuk72	264	12	as	as	IN
cord-001859-d62iuk72	264	13	standard	standard	JJ
cord-001859-d62iuk72	264	14	deviation	deviation	NN
cord-001859-d62iuk72	264	15	.	.	.
cord-001859-d62iuk72	265	1	(	(	-LRB-
cord-001859-d62iuk72	265	2	D	D	NNP
cord-001859-d62iuk72	265	3	)	)	-RRB-
cord-001859-d62iuk72	265	4	Cells	cell	NNS
cord-001859-d62iuk72	265	5	were	be	VBD
cord-001859-d62iuk72	265	6	reactivated	reactivate	VBN
cord-001859-d62iuk72	265	7	for	for	IN
cord-001859-d62iuk72	265	8	72	72	CD
cord-001859-d62iuk72	265	9	h	h	NN
cord-001859-d62iuk72	265	10	,	,	,
cord-001859-d62iuk72	265	11	total	total	JJ
cord-001859-d62iuk72	265	12	DNA	DNA	NNP
cord-001859-d62iuk72	265	13	was	be	VBD
cord-001859-d62iuk72	265	14	isolated	isolate	VBN
cord-001859-d62iuk72	265	15	and	and	CC
cord-001859-d62iuk72	265	16	real	real	JJ
cord-001859-d62iuk72	265	17	-	-	HYPH
cord-001859-d62iuk72	265	18	time	time	NN
cord-001859-d62iuk72	265	19	qPCR	qPCR	NNP
cord-001859-d62iuk72	265	20	was	be	VBD
cord-001859-d62iuk72	265	21	performed	perform	VBN
cord-001859-d62iuk72	265	22	.	.	.
cord-001859-d62iuk72	266	1	Viral	Viral	NNP
cord-001859-d62iuk72	266	2	DNA	DNA	NNP
cord-001859-d62iuk72	266	3	load	load	NN
cord-001859-d62iuk72	266	4	was	be	VBD
cord-001859-d62iuk72	266	5	significantly	significantly	RB
cord-001859-d62iuk72	266	6	decreased	decrease	VBN
cord-001859-d62iuk72	266	7	at	at	IN
cord-001859-d62iuk72	266	8	2	2	CD
cord-001859-d62iuk72	266	9	μM	μm	CD
cord-001859-d62iuk72	266	10	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	266	11	.	.	.
cord-001859-d62iuk72	267	1	Results	result	NNS
cord-001859-d62iuk72	267	2	show	show	VBP
cord-001859-d62iuk72	267	3	the	the	DT
cord-001859-d62iuk72	267	4	mean	mean	NN
cord-001859-d62iuk72	267	5	of	of	IN
cord-001859-d62iuk72	267	6	three	three	CD
cord-001859-d62iuk72	267	7	biological	biological	JJ
cord-001859-d62iuk72	267	8	replicates	replicate	NNS
cord-001859-d62iuk72	267	9	with	with	IN
cord-001859-d62iuk72	267	10	error	error	NN
cord-001859-d62iuk72	267	11	bar	bar	NN
cord-001859-d62iuk72	267	12	as	as	IN
cord-001859-d62iuk72	267	13	standard	standard	JJ
cord-001859-d62iuk72	267	14	deviation	deviation	NN
cord-001859-d62iuk72	267	15	.	.	.
cord-001859-d62iuk72	268	1	(	(	-LRB-
cord-001859-d62iuk72	268	2	E	e	NN
cord-001859-d62iuk72	268	3	)	)	-RRB-
cord-001859-d62iuk72	268	4	TREx	TREx	NNS
cord-001859-d62iuk72	268	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	268	6	cells	cell	NNS
cord-001859-d62iuk72	268	7	were	be	VBD
cord-001859-d62iuk72	268	8	reactivated	reactivate	VBN
cord-001859-d62iuk72	268	9	for	for	IN
cord-001859-d62iuk72	268	10	72	72	CD
cord-001859-d62iuk72	268	11	h	h	NN
cord-001859-d62iuk72	268	12	in	in	IN
cord-001859-d62iuk72	268	13	the	the	DT
cord-001859-d62iuk72	268	14	presence	presence	NN
cord-001859-d62iuk72	268	15	of	of	IN
cord-001859-d62iuk72	268	16	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	268	17	at	at	IN
cord-001859-d62iuk72	268	18	2.5	2.5	CD
cord-001859-d62iuk72	268	19	μM	μm	CD
cord-001859-d62iuk72	268	20	or	or	CC
cord-001859-d62iuk72	268	21	vehicle	vehicle	NN
cord-001859-d62iuk72	268	22	drug	drug	NN
cord-001859-d62iuk72	268	23	DMSO	DMSO	NNP
cord-001859-d62iuk72	268	24	(	(	-LRB-
cord-001859-d62iuk72	268	25	0.1	0.1	CD
cord-001859-d62iuk72	268	26	%	%	NN
cord-001859-d62iuk72	268	27	)	)	-RRB-
cord-001859-d62iuk72	268	28	.	.	.
cord-001859-d62iuk72	269	1	The	the	DT
cord-001859-d62iuk72	269	2	culture	culture	NN
cord-001859-d62iuk72	269	3	medium	medium	NN
cord-001859-d62iuk72	269	4	was	be	VBD
cord-001859-d62iuk72	269	5	then	then	RB
cord-001859-d62iuk72	269	6	incubated	incubate	VBN
cord-001859-d62iuk72	269	7	for	for	IN
cord-001859-d62iuk72	269	8	24	24	CD
cord-001859-d62iuk72	269	9	h	h	NN
cord-001859-d62iuk72	269	10	with	with	IN
cord-001859-d62iuk72	269	11	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	269	12	T	T	NNP
cord-001859-d62iuk72	269	13	cells	cell	NNS
cord-001859-d62iuk72	269	14	followed	follow	VBN
cord-001859-d62iuk72	269	15	by	by	IN
cord-001859-d62iuk72	269	16	total	total	JJ
cord-001859-d62iuk72	269	17	RNA	RNA	NNP
cord-001859-d62iuk72	269	18	extraction	extraction	NN
cord-001859-d62iuk72	269	19	and	and	CC
cord-001859-d62iuk72	269	20	qRT	qRT	NNP
cord-001859-d62iuk72	269	21	-	-	HYPH
cord-001859-d62iuk72	269	22	PCR	PCR	NNP
cord-001859-d62iuk72	269	23	.	.	.
cord-001859-d62iuk72	270	1	A	a	DT
cord-001859-d62iuk72	270	2	significant	significant	JJ
cord-001859-d62iuk72	270	3	decrease	decrease	NN
cord-001859-d62iuk72	270	4	in	in	IN
cord-001859-d62iuk72	270	5	viral	viral	JJ
cord-001859-d62iuk72	270	6	progeny	progeny	NN
cord-001859-d62iuk72	270	7	was	be	VBD
cord-001859-d62iuk72	270	8	seen	see	VBN
cord-001859-d62iuk72	270	9	in	in	IN
cord-001859-d62iuk72	270	10	inhibitor	inhibitor	NN
cord-001859-d62iuk72	270	11	-	-	HYPH
cord-001859-d62iuk72	270	12	treated	treat	VBN
cord-001859-d62iuk72	270	13	cells	cell	NNS
cord-001859-d62iuk72	270	14	.	.	.
cord-001859-d62iuk72	271	1	Results	result	NNS
cord-001859-d62iuk72	271	2	show	show	VBP
cord-001859-d62iuk72	271	3	the	the	DT
cord-001859-d62iuk72	271	4	mean	mean	NN
cord-001859-d62iuk72	271	5	of	of	IN
cord-001859-d62iuk72	271	6	three	three	CD
cord-001859-d62iuk72	271	7	biological	biological	JJ
cord-001859-d62iuk72	271	8	replicates	replicate	NNS
cord-001859-d62iuk72	271	9	with	with	IN
cord-001859-d62iuk72	271	10	error	error	NN
cord-001859-d62iuk72	271	11	bar	bar	NN
cord-001859-d62iuk72	271	12	as	as	IN
cord-001859-d62iuk72	271	13	standard	standard	JJ
cord-001859-d62iuk72	271	14	deviation	deviation	NN
cord-001859-d62iuk72	271	15	.	.	.
cord-001859-d62iuk72	272	1	the	the	DT
cord-001859-d62iuk72	272	2	master	master	NN
cord-001859-d62iuk72	272	3	latent	latent	NN
cord-001859-d62iuk72	272	4	-	-	HYPH
cord-001859-d62iuk72	272	5	lytic	lytic	JJ
cord-001859-d62iuk72	272	6	transactivator	transactivator	NN
cord-001859-d62iuk72	272	7	for	for	IN
cord-001859-d62iuk72	272	8	multiple	multiple	JJ
cord-001859-d62iuk72	272	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	272	10	immediate	immediate	JJ
cord-001859-d62iuk72	272	11	-	-	HYPH
cord-001859-d62iuk72	272	12	early	early	RB
cord-001859-d62iuk72	272	13	,	,	,
cord-001859-d62iuk72	272	14	delayed	delay	VBN
cord-001859-d62iuk72	272	15	-	-	HYPH
cord-001859-d62iuk72	272	16	early	early	JJ
cord-001859-d62iuk72	272	17	and	and	CC
cord-001859-d62iuk72	272	18	late	late	JJ
cord-001859-d62iuk72	272	19	promoters	promoter	NNS
cord-001859-d62iuk72	272	20	[	[	-LRB-
cord-001859-d62iuk72	272	21	66	66	CD
cord-001859-d62iuk72	272	22	]	]	-RRB-
cord-001859-d62iuk72	272	23	[	[	-LRB-
cord-001859-d62iuk72	272	24	67	67	CD
cord-001859-d62iuk72	272	25	]	]	-RRB-
cord-001859-d62iuk72	272	26	[	[	-LRB-
cord-001859-d62iuk72	272	27	68	68	CD
cord-001859-d62iuk72	272	28	]	]	-RRB-
cord-001859-d62iuk72	272	29	[	[	-LRB-
cord-001859-d62iuk72	272	30	69	69	CD
cord-001859-d62iuk72	272	31	]	]	-RRB-
cord-001859-d62iuk72	272	32	[	[	-LRB-
cord-001859-d62iuk72	272	33	70	70	CD
cord-001859-d62iuk72	272	34	]	]	-RRB-
cord-001859-d62iuk72	272	35	,	,	,
cord-001859-d62iuk72	272	36	we	-PRON-	PRP
cord-001859-d62iuk72	272	37	further	further	RB
cord-001859-d62iuk72	272	38	investigated	investigate	VBD
cord-001859-d62iuk72	272	39	the	the	DT
cord-001859-d62iuk72	272	40	possibility	possibility	NN
cord-001859-d62iuk72	272	41	that	that	IN
cord-001859-d62iuk72	272	42	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	272	43	was	be	VBD
cord-001859-d62iuk72	272	44	required	require	VBN
cord-001859-d62iuk72	272	45	for	for	IN
cord-001859-d62iuk72	272	46	RTA	RTA	NNP
cord-001859-d62iuk72	272	47	-	-	HYPH
cord-001859-d62iuk72	272	48	mediated	mediate	VBN
cord-001859-d62iuk72	272	49	transactivation	transactivation	NN
cord-001859-d62iuk72	272	50	.	.	.
cord-001859-d62iuk72	273	1	Initially	initially	RB
cord-001859-d62iuk72	273	2	we	-PRON-	PRP
cord-001859-d62iuk72	273	3	assessed	assess	VBD
cord-001859-d62iuk72	273	4	whether	whether	IN
cord-001859-d62iuk72	273	5	an	an	DT
cord-001859-d62iuk72	273	6	interaction	interaction	NN
cord-001859-d62iuk72	273	7	occurred	occur	VBD
cord-001859-d62iuk72	273	8	between	between	IN
cord-001859-d62iuk72	273	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	273	10	and	and	CC
cord-001859-d62iuk72	273	11	RTA	RTA	NNP
cord-001859-d62iuk72	273	12	in	in	IN
cord-001859-d62iuk72	273	13	the	the	DT
cord-001859-d62iuk72	273	14	absence	absence	NN
cord-001859-d62iuk72	273	15	of	of	IN
cord-001859-d62iuk72	273	16	other	other	JJ
cord-001859-d62iuk72	273	17	viral	viral	JJ
cord-001859-d62iuk72	273	18	proteins	protein	NNS
cord-001859-d62iuk72	273	19	or	or	CC
cord-001859-d62iuk72	273	20	DNA	dna	NN
cord-001859-d62iuk72	273	21	.	.	.
cord-001859-d62iuk72	274	1	For	for	IN
cord-001859-d62iuk72	274	2	this	this	DT
cord-001859-d62iuk72	274	3	,	,	,
cord-001859-d62iuk72	274	4	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	274	5	T	t	NN
cord-001859-d62iuk72	274	6	cells	cell	NNS
cord-001859-d62iuk72	274	7	were	be	VBD
cord-001859-d62iuk72	274	8	transiently	transiently	RB
cord-001859-d62iuk72	274	9	transfected	transfecte	VBN
cord-001859-d62iuk72	274	10	for	for	IN
cord-001859-d62iuk72	274	11	24	24	CD
cord-001859-d62iuk72	274	12	h	h	NN
cord-001859-d62iuk72	274	13	with	with	IN
cord-001859-d62iuk72	274	14	control	control	NN
cord-001859-d62iuk72	274	15	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	274	16	or	or	CC
cord-001859-d62iuk72	274	17	pRTA	prta	JJ
cord-001859-d62iuk72	274	18	-	-	JJ
cord-001859-d62iuk72	274	19	EGFP	EGFP	NNP
cord-001859-d62iuk72	274	20	and	and	CC
cord-001859-d62iuk72	274	21	immunoprecipitations	immunoprecipitation	NNS
cord-001859-d62iuk72	274	22	were	be	VBD
cord-001859-d62iuk72	274	23	carried	carry	VBN
cord-001859-d62iuk72	274	24	out	out	RP
cord-001859-d62iuk72	274	25	using	use	VBG
cord-001859-d62iuk72	274	26	a	a	DT
cord-001859-d62iuk72	274	27	GFP	GFP	NNP
cord-001859-d62iuk72	274	28	-	-	HYPH
cord-001859-d62iuk72	274	29	specific	specific	JJ
cord-001859-d62iuk72	274	30	antibody	antibody	NN
cord-001859-d62iuk72	274	31	.	.	.
cord-001859-d62iuk72	275	1	RTA	RTA	NNP
cord-001859-d62iuk72	275	2	-	-	HYPH
cord-001859-d62iuk72	275	3	EGFP	EGFP	NNP
cord-001859-d62iuk72	275	4	precipitated	precipitate	VBD
cord-001859-d62iuk72	275	5	endogenous	endogenous	JJ
cord-001859-d62iuk72	275	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	275	7	in	in	IN
cord-001859-d62iuk72	275	8	contrast	contrast	NN
cord-001859-d62iuk72	275	9	to	to	IN
cord-001859-d62iuk72	275	10	the	the	DT
cord-001859-d62iuk72	275	11	control	control	NN
cord-001859-d62iuk72	275	12	EGFP	EGFP	NNP
cord-001859-d62iuk72	275	13	protein	protein	NN
cord-001859-d62iuk72	275	14	(	(	-LRB-
cord-001859-d62iuk72	275	15	Fig	Fig	NNP
cord-001859-d62iuk72	275	16	7A	7a	NN
cord-001859-d62iuk72	275	17	)	)	-RRB-
cord-001859-d62iuk72	275	18	.	.	.
cord-001859-d62iuk72	276	1	In	in	IN
cord-001859-d62iuk72	276	2	addition	addition	NN
cord-001859-d62iuk72	276	3	,	,	,
cord-001859-d62iuk72	276	4	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	276	5	T	t	NN
cord-001859-d62iuk72	276	6	cells	cell	NNS
cord-001859-d62iuk72	276	7	were	be	VBD
cord-001859-d62iuk72	276	8	transfected	transfecte	VBN
cord-001859-d62iuk72	276	9	with	with	IN
cord-001859-d62iuk72	276	10	control	control	NN
cord-001859-d62iuk72	276	11	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	276	12	or	or	CC
cord-001859-d62iuk72	276	13	pRTA	prta	JJ
cord-001859-d62iuk72	276	14	-	-	JJ
cord-001859-d62iuk72	276	15	EGFP	EGFP	NNP
cord-001859-d62iuk72	276	16	for	for	IN
cord-001859-d62iuk72	276	17	24	24	CD
cord-001859-d62iuk72	276	18	h	h	NN
cord-001859-d62iuk72	276	19	and	and	CC
cord-001859-d62iuk72	276	20	examined	examine	VBN
cord-001859-d62iuk72	276	21	by	by	IN
cord-001859-d62iuk72	276	22	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	276	23	.	.	.
cord-001859-d62iuk72	277	1	In	in	IN
cord-001859-d62iuk72	277	2	cells	cell	NNS
cord-001859-d62iuk72	277	3	expressing	express	VBG
cord-001859-d62iuk72	277	4	EGFP	EGFP	NNP
cord-001859-d62iuk72	277	5	protein	protein	NN
cord-001859-d62iuk72	277	6	,	,	,
cord-001859-d62iuk72	277	7	endogenous	endogenous	JJ
cord-001859-d62iuk72	277	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	277	9	remained	remain	VBD
cord-001859-d62iuk72	277	10	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	277	11	(	(	-LRB-
cord-001859-d62iuk72	277	12	Fig	Fig	NNP
cord-001859-d62iuk72	277	13	7Bi	7Bi	NNP
cord-001859-d62iuk72	277	14	)	)	-RRB-
cord-001859-d62iuk72	277	15	,	,	,
cord-001859-d62iuk72	277	16	while	while	IN
cord-001859-d62iuk72	277	17	in	in	IN
cord-001859-d62iuk72	277	18	EGFP	EGFP	NNP
cord-001859-d62iuk72	277	19	-	-	HYPH
cord-001859-d62iuk72	277	20	RTA	RTA	NNP
cord-001859-d62iuk72	277	21	-	-	HYPH
cord-001859-d62iuk72	277	22	expressing	express	VBG
cord-001859-d62iuk72	277	23	cells	cell	NNS
cord-001859-d62iuk72	277	24	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	277	25	strongly	strongly	RB
cord-001859-d62iuk72	277	26	co	co	VBZ
cord-001859-d62iuk72	277	27	-	-	JJ
cord-001859-d62iuk72	277	28	localised	localised	JJ
cord-001859-d62iuk72	277	29	with	with	IN
cord-001859-d62iuk72	277	30	RTA	RTA	NNP
cord-001859-d62iuk72	277	31	in	in	IN
cord-001859-d62iuk72	277	32	the	the	DT
cord-001859-d62iuk72	277	33	nuclei	nucleus	NNS
cord-001859-d62iuk72	277	34	,	,	,
cord-001859-d62iuk72	277	35	suggesting	suggest	VBG
cord-001859-d62iuk72	277	36	RTA	RTA	NNP
cord-001859-d62iuk72	277	37	expression	expression	NN
cord-001859-d62iuk72	277	38	alone	alone	RB
cord-001859-d62iuk72	277	39	is	be	VBZ
cord-001859-d62iuk72	277	40	sufficient	sufficient	JJ
cord-001859-d62iuk72	277	41	to	to	TO
cord-001859-d62iuk72	277	42	redistribute	redistribute	VB
cord-001859-d62iuk72	277	43	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	277	44	into	into	IN
cord-001859-d62iuk72	277	45	the	the	DT
cord-001859-d62iuk72	277	46	nucleus	nucleus	NN
cord-001859-d62iuk72	277	47	(	(	-LRB-
cord-001859-d62iuk72	277	48	Fig	Fig	NNP
cord-001859-d62iuk72	277	49	7Bii	7bii	CD
cord-001859-d62iuk72	277	50	)	)	-RRB-
cord-001859-d62iuk72	277	51	.	.	.
cord-001859-d62iuk72	278	1	Similar	similar	JJ
cord-001859-d62iuk72	278	2	nuclear	nuclear	JJ
cord-001859-d62iuk72	278	3	redistribution	redistribution	NN
cord-001859-d62iuk72	278	4	was	be	VBD
cord-001859-d62iuk72	278	5	also	also	RB
cord-001859-d62iuk72	278	6	seen	see	VBN
cord-001859-d62iuk72	278	7	for	for	IN
cord-001859-d62iuk72	278	8	endogenous	endogenous	JJ
cord-001859-d62iuk72	278	9	iHsp70	iHsp70	.
cord-001859-d62iuk72	279	1	(	(	-LRB-
cord-001859-d62iuk72	279	2	S5	S5	NNP
cord-001859-d62iuk72	279	3	Fig	Fig	NNP
cord-001859-d62iuk72	279	4	)	)	-RRB-
cord-001859-d62iuk72	279	5	.	.	.
cord-001859-d62iuk72	280	1	Next	next	RB
cord-001859-d62iuk72	280	2	,	,	,
cord-001859-d62iuk72	280	3	we	-PRON-	PRP
cord-001859-d62iuk72	280	4	determined	determine	VBD
cord-001859-d62iuk72	280	5	whether	whether	IN
cord-001859-d62iuk72	280	6	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	280	7	was	be	VBD
cord-001859-d62iuk72	280	8	able	able	JJ
cord-001859-d62iuk72	280	9	to	to	TO
cord-001859-d62iuk72	280	10	disrupt	disrupt	VB
cord-001859-d62iuk72	280	11	the	the	DT
cord-001859-d62iuk72	280	12	interaction	interaction	NN
cord-001859-d62iuk72	280	13	between	between	IN
cord-001859-d62iuk72	280	14	EGFP	EGFP	NNP
cord-001859-d62iuk72	280	15	-	-	HYPH
cord-001859-d62iuk72	280	16	RTA	RTA	NNP
cord-001859-d62iuk72	280	17	and	and	CC
cord-001859-d62iuk72	280	18	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	280	19	in	in	IN
cord-001859-d62iuk72	280	20	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	280	21	T	T	NNP
cord-001859-d62iuk72	280	22	cells	cell	NNS
cord-001859-d62iuk72	280	23	.	.	.
cord-001859-d62iuk72	281	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	282	1	T	T	NNP
cord-001859-d62iuk72	282	2	cells	cell	NNS
cord-001859-d62iuk72	282	3	exhibited	exhibit	VBD
cord-001859-d62iuk72	282	4	a	a	DT
cord-001859-d62iuk72	282	5	very	very	RB
cord-001859-d62iuk72	282	6	similar	similar	JJ
cord-001859-d62iuk72	282	7	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	282	8	profile	profile	NN
cord-001859-d62iuk72	282	9	to	to	IN
cord-001859-d62iuk72	282	10	that	that	DT
cord-001859-d62iuk72	282	11	seen	see	VBN
cord-001859-d62iuk72	282	12	in	in	IN
cord-001859-d62iuk72	282	13	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	282	14	T	t	NN
cord-001859-d62iuk72	282	15	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	282	16	cells	cell	NNS
cord-001859-d62iuk72	282	17	(	(	-LRB-
cord-001859-d62iuk72	282	18	S6	S6	NNP
cord-001859-d62iuk72	282	19	Fig	Fig	NNP
cord-001859-d62iuk72	282	20	)	)	-RRB-
cord-001859-d62iuk72	282	21	.	.	.
cord-001859-d62iuk72	283	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	284	1	T	t	NN
cord-001859-d62iuk72	284	2	cells	cell	NNS
cord-001859-d62iuk72	284	3	were	be	VBD
cord-001859-d62iuk72	284	4	transiently	transiently	RB
cord-001859-d62iuk72	284	5	transfected	transfecte	VBN
cord-001859-d62iuk72	284	6	with	with	IN
cord-001859-d62iuk72	284	7	pRTA	prta	JJ
cord-001859-d62iuk72	284	8	-	-	JJ
cord-001859-d62iuk72	284	9	EGFP	egfp	JJ
cord-001859-d62iuk72	284	10	or	or	CC
cord-001859-d62iuk72	284	11	control	control	VB
cord-001859-d62iuk72	284	12	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	284	13	.	.	.
cord-001859-d62iuk72	285	1	To	to	TO
cord-001859-d62iuk72	285	2	allow	allow	VB
cord-001859-d62iuk72	285	3	maximal	maximal	JJ
cord-001859-d62iuk72	285	4	protein	protein	NN
cord-001859-d62iuk72	285	5	expression	expression	NN
cord-001859-d62iuk72	285	6	and	and	CC
cord-001859-d62iuk72	285	7	avoid	avoid	VB
cord-001859-d62iuk72	285	8	interference	interference	NN
cord-001859-d62iuk72	285	9	of	of	IN
cord-001859-d62iuk72	285	10	the	the	DT
cord-001859-d62iuk72	285	11	inhibitor	inhibitor	NN
cord-001859-d62iuk72	285	12	with	with	IN
cord-001859-d62iuk72	285	13	the	the	DT
cord-001859-d62iuk72	285	14	transfection	transfection	NN
cord-001859-d62iuk72	285	15	,	,	,
cord-001859-d62iuk72	285	16	the	the	DT
cord-001859-d62iuk72	285	17	inhibitor	inhibitor	NN
cord-001859-d62iuk72	285	18	was	be	VBD
cord-001859-d62iuk72	285	19	added	add	VBN
cord-001859-d62iuk72	285	20	at	at	IN
cord-001859-d62iuk72	285	21	24	24	CD
cord-001859-d62iuk72	285	22	h	h	NN
cord-001859-d62iuk72	285	23	post	post	NN
cord-001859-d62iuk72	285	24	-	-	NN
cord-001859-d62iuk72	285	25	transfection	transfection	JJ
cord-001859-d62iuk72	285	26	and	and	CC
cord-001859-d62iuk72	285	27	incubated	incubate	VBN
cord-001859-d62iuk72	285	28	for	for	IN
cord-001859-d62iuk72	285	29	a	a	DT
cord-001859-d62iuk72	285	30	further	further	JJ
cord-001859-d62iuk72	285	31	24	24	CD
cord-001859-d62iuk72	285	32	h	h	NN
cord-001859-d62iuk72	285	33	,	,	,
cord-001859-d62iuk72	285	34	prior	prior	RB
cord-001859-d62iuk72	285	35	to	to	IN
cord-001859-d62iuk72	285	36	immunoprecipitations	immunoprecipitation	NNS
cord-001859-d62iuk72	285	37	being	be	VBG
cord-001859-d62iuk72	285	38	performed	perform	VBN
cord-001859-d62iuk72	285	39	.	.	.
cord-001859-d62iuk72	286	1	Western	western	JJ
cord-001859-d62iuk72	286	2	blot	blot	NN
cord-001859-d62iuk72	286	3	analysis	analysis	NN
cord-001859-d62iuk72	286	4	revealed	reveal	VBD
cord-001859-d62iuk72	286	5	that	that	IN
cord-001859-d62iuk72	286	6	the	the	DT
cord-001859-d62iuk72	286	7	inhibitor	inhibitor	NN
cord-001859-d62iuk72	286	8	did	do	VBD
cord-001859-d62iuk72	286	9	not	not	RB
cord-001859-d62iuk72	286	10	disrupt	disrupt	VB
cord-001859-d62iuk72	286	11	the	the	DT
cord-001859-d62iuk72	286	12	interaction	interaction	NN
cord-001859-d62iuk72	286	13	between	between	IN
cord-001859-d62iuk72	286	14	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	286	15	and	and	CC
cord-001859-d62iuk72	286	16	RTA	RTA	NNP
cord-001859-d62iuk72	286	17	even	even	RB
cord-001859-d62iuk72	286	18	at	at	IN
cord-001859-d62iuk72	286	19	high	high	JJ
cord-001859-d62iuk72	286	20	inhibitor	inhibitor	NN
cord-001859-d62iuk72	286	21	concentrations	concentration	NNS
cord-001859-d62iuk72	286	22	(	(	-LRB-
cord-001859-d62iuk72	286	23	55	55	CD
cord-001859-d62iuk72	286	24	μM	μm	CD
cord-001859-d62iuk72	286	25	)	)	-RRB-
cord-001859-d62iuk72	286	26	(	(	-LRB-
cord-001859-d62iuk72	286	27	Fig	Fig	NNP
cord-001859-d62iuk72	286	28	7C	7C	NNP
cord-001859-d62iuk72	286	29	)	)	-RRB-
cord-001859-d62iuk72	286	30	,	,	,
cord-001859-d62iuk72	286	31	suggesting	suggest	VBG
cord-001859-d62iuk72	286	32	that	that	IN
cord-001859-d62iuk72	286	33	the	the	DT
cord-001859-d62iuk72	286	34	ATPase	ATPase	NNP
cord-001859-d62iuk72	286	35	function	function	NN
cord-001859-d62iuk72	286	36	of	of	IN
cord-001859-d62iuk72	286	37	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	286	38	is	be	VBZ
cord-001859-d62iuk72	286	39	not	not	RB
cord-001859-d62iuk72	286	40	required	require	VBN
cord-001859-d62iuk72	286	41	for	for	IN
cord-001859-d62iuk72	286	42	the	the	DT
cord-001859-d62iuk72	286	43	interaction	interaction	NN
cord-001859-d62iuk72	286	44	with	with	IN
cord-001859-d62iuk72	286	45	RTA	RTA	NNP
cord-001859-d62iuk72	286	46	protein	protein	NN
cord-001859-d62iuk72	286	47	.	.	.
cord-001859-d62iuk72	287	1	Therefore	therefore	RB
cord-001859-d62iuk72	287	2	,	,	,
cord-001859-d62iuk72	287	3	to	to	TO
cord-001859-d62iuk72	287	4	investigate	investigate	VB
cord-001859-d62iuk72	287	5	whether	whether	IN
cord-001859-d62iuk72	287	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	287	7	was	be	VBD
cord-001859-d62iuk72	287	8	required	require	VBN
cord-001859-d62iuk72	287	9	for	for	IN
cord-001859-d62iuk72	287	10	RTA	RTA	NNP
cord-001859-d62iuk72	287	11	-	-	HYPH
cord-001859-d62iuk72	287	12	mediated	mediate	VBN
cord-001859-d62iuk72	287	13	transactivation	transactivation	NN
cord-001859-d62iuk72	287	14	of	of	IN
cord-001859-d62iuk72	287	15	the	the	DT
cord-001859-d62iuk72	287	16	RTA	RTA	NNP
cord-001859-d62iuk72	287	17	-	-	HYPH
cord-001859-d62iuk72	287	18	responsive	responsive	JJ
cord-001859-d62iuk72	287	19	ORF57	ORF57	NNP
cord-001859-d62iuk72	287	20	promoter	promoter	NN
cord-001859-d62iuk72	287	21	,	,	,
cord-001859-d62iuk72	287	22	a	a	DT
cord-001859-d62iuk72	287	23	dual	dual	JJ
cord-001859-d62iuk72	287	24	-	-	HYPH
cord-001859-d62iuk72	287	25	luciferase	luciferase	JJ
cord-001859-d62iuk72	287	26	reporter	reporter	NN
cord-001859-d62iuk72	287	27	assay	assay	NN
cord-001859-d62iuk72	287	28	system	system	NN
cord-001859-d62iuk72	287	29	was	be	VBD
cord-001859-d62iuk72	287	30	utilised	utilise	VBN
cord-001859-d62iuk72	287	31	.	.	.
cord-001859-d62iuk72	288	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	288	2	T	t	NN
cord-001859-d62iuk72	288	3	cells	cell	NNS
cord-001859-d62iuk72	288	4	were	be	VBD
cord-001859-d62iuk72	288	5	co	co	JJ
cord-001859-d62iuk72	288	6	-	-	VBN
cord-001859-d62iuk72	288	7	transfected	transfecte	VBN
cord-001859-d62iuk72	288	8	with	with	IN
cord-001859-d62iuk72	288	9	pRTA	prta	JJ
cord-001859-d62iuk72	288	10	-	-	JJ
cord-001859-d62iuk72	288	11	EGFP	egfp	NN
cord-001859-d62iuk72	288	12	along	along	IN
cord-001859-d62iuk72	288	13	with	with	IN
cord-001859-d62iuk72	288	14	the	the	DT
cord-001859-d62iuk72	288	15	Renilla	Renilla	NNP
cord-001859-d62iuk72	288	16	luciferase	luciferase	NN
cord-001859-d62iuk72	288	17	vector	vector	NN
cord-001859-d62iuk72	288	18	and	and	CC
cord-001859-d62iuk72	288	19	either	either	CC
cord-001859-d62iuk72	288	20	the	the	DT
cord-001859-d62iuk72	288	21	ORF57	ORF57	NNP
cord-001859-d62iuk72	288	22	promoter	promoter	NN
cord-001859-d62iuk72	288	23	firefly	firefly	NN
cord-001859-d62iuk72	288	24	luciferase	luciferase	NNP
cord-001859-d62iuk72	288	25	reporter	reporter	NN
cord-001859-d62iuk72	288	26	vector	vector	NN
cord-001859-d62iuk72	288	27	,	,	,
cord-001859-d62iuk72	288	28	or	or	CC
cord-001859-d62iuk72	288	29	the	the	DT
cord-001859-d62iuk72	288	30	empty	empty	JJ
cord-001859-d62iuk72	288	31	reporter	reporter	NN
cord-001859-d62iuk72	288	32	vector	vector	NN
cord-001859-d62iuk72	288	33	(	(	-LRB-
cord-001859-d62iuk72	288	34	pGL3-BASIC	pGL3-BASIC	NNP
cord-001859-d62iuk72	288	35	)	)	-RRB-
cord-001859-d62iuk72	288	36	.	.	.
cord-001859-d62iuk72	289	1	The	the	DT
cord-001859-d62iuk72	289	2	same	same	JJ
cord-001859-d62iuk72	289	3	co	co	NNS
cord-001859-d62iuk72	289	4	-	-	NNS
cord-001859-d62iuk72	289	5	transfections	transfection	NNS
cord-001859-d62iuk72	289	6	were	be	VBD
cord-001859-d62iuk72	289	7	performed	perform	VBN
cord-001859-d62iuk72	289	8	using	use	VBG
cord-001859-d62iuk72	289	9	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	289	10	,	,	,
cord-001859-d62iuk72	289	11	as	as	IN
cord-001859-d62iuk72	289	12	a	a	DT
cord-001859-d62iuk72	289	13	negative	negative	JJ
cord-001859-d62iuk72	289	14	control	control	NN
cord-001859-d62iuk72	289	15	.	.	.
cord-001859-d62iuk72	290	1	24	24	CD
cord-001859-d62iuk72	291	1	h	h	LS
cord-001859-d62iuk72	291	2	post	post	NN
cord-001859-d62iuk72	291	3	-	-	NN
cord-001859-d62iuk72	291	4	transfection	transfection	JJ
cord-001859-d62iuk72	291	5	,	,	,
cord-001859-d62iuk72	291	6	cells	cell	NNS
cord-001859-d62iuk72	291	7	were	be	VBD
cord-001859-d62iuk72	291	8	exposed	expose	VBN
cord-001859-d62iuk72	291	9	for	for	IN
cord-001859-d62iuk72	291	10	2	2	CD
cord-001859-d62iuk72	291	11	h	h	NN
cord-001859-d62iuk72	291	12	to	to	IN
cord-001859-d62iuk72	291	13	increasing	increase	VBG
cord-001859-d62iuk72	291	14	concentrations	concentration	NNS
cord-001859-d62iuk72	291	15	of	of	IN
cord-001859-d62iuk72	291	16	VER-155008	ver-155008	NN
cord-001859-d62iuk72	291	17	and	and	CC
cord-001859-d62iuk72	291	18	luciferase	luciferase	NN
cord-001859-d62iuk72	291	19	activities	activity	NNS
cord-001859-d62iuk72	291	20	were	be	VBD
cord-001859-d62iuk72	291	21	measured	measure	VBN
cord-001859-d62iuk72	291	22	.	.	.
cord-001859-d62iuk72	292	1	Longer	long	JJR
cord-001859-d62iuk72	292	2	exposure	exposure	NN
cord-001859-d62iuk72	292	3	times	time	NNS
cord-001859-d62iuk72	292	4	to	to	IN
cord-001859-d62iuk72	292	5	the	the	DT
cord-001859-d62iuk72	292	6	inhibitor	inhibitor	NN
cord-001859-d62iuk72	292	7	affected	affect	VBD
cord-001859-d62iuk72	292	8	the	the	DT
cord-001859-d62iuk72	292	9	formation	formation	NN
cord-001859-d62iuk72	292	10	of	of	IN
cord-001859-d62iuk72	292	11	the	the	DT
cord-001859-d62iuk72	292	12	control	control	NN
cord-001859-d62iuk72	292	13	Renilla	Renilla	NNP
cord-001859-d62iuk72	292	14	luciferase	luciferase	NN
cord-001859-d62iuk72	292	15	protein	protein	NN
cord-001859-d62iuk72	292	16	which	which	WDT
cord-001859-d62iuk72	292	17	has	have	VBZ
cord-001859-d62iuk72	292	18	a	a	DT
cord-001859-d62iuk72	292	19	half	half	JJ
cord-001859-d62iuk72	292	20	-	-	HYPH
cord-001859-d62iuk72	292	21	life	life	NN
cord-001859-d62iuk72	292	22	of	of	IN
cord-001859-d62iuk72	292	23	3	3	CD
cord-001859-d62iuk72	292	24	h	h	NN
cord-001859-d62iuk72	292	25	,	,	,
cord-001859-d62iuk72	292	26	suggesting	suggest	VBG
cord-001859-d62iuk72	292	27	that	that	IN
cord-001859-d62iuk72	292	28	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	292	29	isoforms	isoform	NNS
cord-001859-d62iuk72	292	30	may	may	MD
cord-001859-d62iuk72	292	31	be	be	VB
cord-001859-d62iuk72	292	32	required	require	VBN
cord-001859-d62iuk72	292	33	for	for	IN
cord-001859-d62iuk72	292	34	the	the	DT
cord-001859-d62iuk72	292	35	folding	folding	NN
cord-001859-d62iuk72	292	36	/	/	SYM
cord-001859-d62iuk72	292	37	maturation	maturation	NN
cord-001859-d62iuk72	292	38	of	of	IN
cord-001859-d62iuk72	292	39	this	this	DT
cord-001859-d62iuk72	292	40	enzyme	enzyme	NN
cord-001859-d62iuk72	292	41	.	.	.
cord-001859-d62iuk72	293	1	In	in	IN
cord-001859-d62iuk72	293	2	the	the	DT
cord-001859-d62iuk72	293	3	presence	presence	NN
cord-001859-d62iuk72	293	4	of	of	IN
cord-001859-d62iuk72	293	5	EGFP	EGFP	NNP
cord-001859-d62iuk72	293	6	-	-	HYPH
cord-001859-d62iuk72	293	7	RTA	RTA	NNP
cord-001859-d62iuk72	293	8	and	and	CC
cord-001859-d62iuk72	293	9	the	the	DT
cord-001859-d62iuk72	293	10	ORF57	ORF57	NNP
cord-001859-d62iuk72	293	11	promoter	promoter	NN
cord-001859-d62iuk72	293	12	reporter	reporter	NN
cord-001859-d62iuk72	293	13	construct	construct	VB
cord-001859-d62iuk72	293	14	,	,	,
cord-001859-d62iuk72	293	15	the	the	DT
cord-001859-d62iuk72	293	16	ORF57	ORF57	NNP
cord-001859-d62iuk72	293	17	promoter	promoter	NN
cord-001859-d62iuk72	293	18	activity	activity	NN
cord-001859-d62iuk72	293	19	was	be	VBD
cord-001859-d62iuk72	293	20	increased~30-fold	increased~30-fold	JJ
cord-001859-d62iuk72	293	21	,	,	,
cord-001859-d62iuk72	293	22	while	while	IN
cord-001859-d62iuk72	293	23	the	the	DT
cord-001859-d62iuk72	293	24	empty	empty	JJ
cord-001859-d62iuk72	293	25	vector	vector	NN
cord-001859-d62iuk72	293	26	had	have	VBD
cord-001859-d62iuk72	293	27	a~4-fold	a~4-fold	DT
cord-001859-d62iuk72	293	28	increase	increase	NN
cord-001859-d62iuk72	293	29	.	.	.
cord-001859-d62iuk72	294	1	However	however	RB
cord-001859-d62iuk72	294	2	,	,	,
cord-001859-d62iuk72	294	3	ORF57	ORF57	NNP
cord-001859-d62iuk72	294	4	promoter	promoter	NN
cord-001859-d62iuk72	294	5	activity	activity	NN
cord-001859-d62iuk72	294	6	was	be	VBD
cord-001859-d62iuk72	294	7	not	not	RB
cord-001859-d62iuk72	294	8	significantly	significantly	RB
cord-001859-d62iuk72	294	9	decreased	decrease	VBN
cord-001859-d62iuk72	294	10	in	in	IN
cord-001859-d62iuk72	294	11	the	the	DT
cord-001859-d62iuk72	294	12	presence	presence	NN
cord-001859-d62iuk72	294	13	of	of	IN
cord-001859-d62iuk72	294	14	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	295	1	(	(	-LRB-
cord-001859-d62iuk72	295	2	Fig	Fig	NNP
cord-001859-d62iuk72	295	3	7D	7D	NNP
cord-001859-d62iuk72	295	4	)	)	-RRB-
cord-001859-d62iuk72	295	5	.	.	.
cord-001859-d62iuk72	296	1	To	to	TO
cord-001859-d62iuk72	296	2	confirm	confirm	VB
cord-001859-d62iuk72	296	3	this	this	DT
cord-001859-d62iuk72	296	4	result	result	NN
cord-001859-d62iuk72	296	5	,	,	,
cord-001859-d62iuk72	296	6	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	296	7	T	t	NN
cord-001859-d62iuk72	296	8	cells	cell	NNS
cord-001859-d62iuk72	296	9	were	be	VBD
cord-001859-d62iuk72	296	10	also	also	RB
cord-001859-d62iuk72	296	11	transiently	transiently	RB
cord-001859-d62iuk72	296	12	co	co	VBN
cord-001859-d62iuk72	296	13	-	-	VBN
cord-001859-d62iuk72	296	14	transfected	transfecte	VBN
cord-001859-d62iuk72	296	15	with	with	IN
cord-001859-d62iuk72	296	16	pPAN	pPAN	NNP
cord-001859-d62iuk72	296	17	-	-	HYPH
cord-001859-d62iuk72	296	18	WT	WT	NNP
cord-001859-d62iuk72	296	19	,	,	,
cord-001859-d62iuk72	296	20	a	a	DT
cord-001859-d62iuk72	296	21	plasmid	plasmid	NN
cord-001859-d62iuk72	296	22	encoding	encode	VBG
cord-001859-d62iuk72	296	23	the	the	DT
cord-001859-d62iuk72	296	24	genomic	genomic	JJ
cord-001859-d62iuk72	296	25	region	region	NN
cord-001859-d62iuk72	296	26	of	of	IN
cord-001859-d62iuk72	296	27	wild	wild	JJ
cord-001859-d62iuk72	296	28	type	type	NN
cord-001859-d62iuk72	296	29	PAN	PAN	NNP
cord-001859-d62iuk72	296	30	RNA	RNA	NNP
cord-001859-d62iuk72	296	31	including	include	VBG
cord-001859-d62iuk72	296	32	its	-PRON-	PRP$
cord-001859-d62iuk72	296	33	promoter	promoter	NN
cord-001859-d62iuk72	296	34	region	region	NN
cord-001859-d62iuk72	296	35	[	[	-LRB-
cord-001859-d62iuk72	296	36	71	71	CD
cord-001859-d62iuk72	296	37	]	]	-RRB-
cord-001859-d62iuk72	296	38	,	,	,
cord-001859-d62iuk72	296	39	and	and	CC
cord-001859-d62iuk72	296	40	either	either	DT
cord-001859-d62iuk72	296	41	pRTA	prta	JJ
cord-001859-d62iuk72	296	42	-	-	JJ
cord-001859-d62iuk72	296	43	EGFP	egfp	NN
cord-001859-d62iuk72	296	44	or	or	CC
cord-001859-d62iuk72	296	45	control	control	NN
cord-001859-d62iuk72	297	1	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	297	2	.	.	.
cord-001859-d62iuk72	298	1	24	24	CD
cord-001859-d62iuk72	299	1	h	h	LS
cord-001859-d62iuk72	299	2	post	post	NN
cord-001859-d62iuk72	299	3	-	-	NN
cord-001859-d62iuk72	299	4	transfection	transfection	NN
cord-001859-d62iuk72	299	5	either	either	DT
cord-001859-d62iuk72	299	6	vehicle	vehicle	NN
cord-001859-d62iuk72	299	7	drug	drug	NN
cord-001859-d62iuk72	299	8	DMSO	DMSO	NNP
cord-001859-d62iuk72	299	9	or	or	CC
cord-001859-d62iuk72	299	10	VER-155008	ver-155008	NN
cord-001859-d62iuk72	299	11	at	at	IN
cord-001859-d62iuk72	299	12	45	45	CD
cord-001859-d62iuk72	299	13	μM	μm	NN
cord-001859-d62iuk72	299	14	was	be	VBD
cord-001859-d62iuk72	299	15	added	add	VBN
cord-001859-d62iuk72	299	16	and	and	CC
cord-001859-d62iuk72	299	17	incubated	incubate	VBN
cord-001859-d62iuk72	299	18	for	for	IN
cord-001859-d62iuk72	299	19	a	a	DT
cord-001859-d62iuk72	299	20	further	further	JJ
cord-001859-d62iuk72	299	21	24	24	CD
cord-001859-d62iuk72	299	22	h	h	NN
cord-001859-d62iuk72	299	23	followed	follow	VBN
cord-001859-d62iuk72	299	24	by	by	IN
cord-001859-d62iuk72	299	25	qRT	qRT	NNP
cord-001859-d62iuk72	299	26	-	-	HYPH
cord-001859-d62iuk72	299	27	PCR	PCR	NNP
cord-001859-d62iuk72	299	28	.	.	.
cord-001859-d62iuk72	300	1	In	in	IN
cord-001859-d62iuk72	300	2	Quantification	quantification	NN
cord-001859-d62iuk72	300	3	by	by	IN
cord-001859-d62iuk72	300	4	RT	RT	NNP
cord-001859-d62iuk72	300	5	-	-	HYPH
cord-001859-d62iuk72	300	6	PCR	PCR	NNP
cord-001859-d62iuk72	300	7	of	of	IN
cord-001859-d62iuk72	300	8	immediate	immediate	JJ
cord-001859-d62iuk72	300	9	-	-	HYPH
cord-001859-d62iuk72	300	10	early	early	JJ
cord-001859-d62iuk72	300	11	(	(	-LRB-
cord-001859-d62iuk72	300	12	blue	blue	JJ
cord-001859-d62iuk72	300	13	colour	colour	NN
cord-001859-d62iuk72	300	14	)	)	-RRB-
cord-001859-d62iuk72	300	15	,	,	,
cord-001859-d62iuk72	300	16	early	early	JJ
cord-001859-d62iuk72	300	17	(	(	-LRB-
cord-001859-d62iuk72	300	18	orange	orange	JJ
cord-001859-d62iuk72	300	19	colour	colour	NN
cord-001859-d62iuk72	300	20	)	)	-RRB-
cord-001859-d62iuk72	300	21	,	,	,
cord-001859-d62iuk72	300	22	late	late	JJ
cord-001859-d62iuk72	300	23	(	(	-LRB-
cord-001859-d62iuk72	300	24	red	red	JJ
cord-001859-d62iuk72	300	25	colour	colour	NN
cord-001859-d62iuk72	300	26	)	)	-RRB-
cord-001859-d62iuk72	300	27	and	and	CC
cord-001859-d62iuk72	300	28	ori	ori	NNP
cord-001859-d62iuk72	300	29	-	-	HYPH
cord-001859-d62iuk72	300	30	Lyt	lyt	JJ
cord-001859-d62iuk72	300	31	viral	viral	JJ
cord-001859-d62iuk72	300	32	transcripts	transcript	NNS
cord-001859-d62iuk72	300	33	showed	show	VBD
cord-001859-d62iuk72	300	34	that	that	IN
cord-001859-d62iuk72	300	35	all	all	DT
cord-001859-d62iuk72	300	36	transcripts	transcript	NNS
cord-001859-d62iuk72	300	37	were	be	VBD
cord-001859-d62iuk72	300	38	significantly	significantly	RB
cord-001859-d62iuk72	300	39	decreased	decrease	VBN
cord-001859-d62iuk72	300	40	at	at	IN
cord-001859-d62iuk72	300	41	25	25	CD
cord-001859-d62iuk72	300	42	μM	μm	CD
cord-001859-d62iuk72	300	43	VER-155008	VER-155008	NNS
cord-001859-d62iuk72	300	44	compared	compare	VBN
cord-001859-d62iuk72	300	45	to	to	IN
cord-001859-d62iuk72	300	46	the	the	DT
cord-001859-d62iuk72	300	47	levels	level	NNS
cord-001859-d62iuk72	300	48	found	find	VBN
cord-001859-d62iuk72	300	49	in	in	IN
cord-001859-d62iuk72	300	50	DMSO	DMSO	NNP
cord-001859-d62iuk72	300	51	-	-	HYPH
cord-001859-d62iuk72	300	52	treated	treat	VBN
cord-001859-d62iuk72	300	53	samples	sample	NNS
cord-001859-d62iuk72	300	54	.	.	.
cord-001859-d62iuk72	301	1	All	all	DT
cord-001859-d62iuk72	301	2	samples	sample	NNS
cord-001859-d62iuk72	301	3	were	be	VBD
cord-001859-d62iuk72	301	4	normalised	normalise	VBN
cord-001859-d62iuk72	301	5	to	to	IN
cord-001859-d62iuk72	301	6	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	301	7	.	.	.
cord-001859-d62iuk72	302	1	Results	result	NNS
cord-001859-d62iuk72	302	2	show	show	VBP
cord-001859-d62iuk72	302	3	the	the	DT
cord-001859-d62iuk72	302	4	mean	mean	NN
cord-001859-d62iuk72	302	5	of	of	IN
cord-001859-d62iuk72	302	6	three	three	CD
cord-001859-d62iuk72	302	7	biological	biological	JJ
cord-001859-d62iuk72	302	8	replicates	replicate	NNS
cord-001859-d62iuk72	302	9	with	with	IN
cord-001859-d62iuk72	302	10	error	error	NN
cord-001859-d62iuk72	302	11	bar	bar	NN
cord-001859-d62iuk72	302	12	as	as	IN
cord-001859-d62iuk72	302	13	standard	standard	JJ
cord-001859-d62iuk72	302	14	deviation	deviation	NN
cord-001859-d62iuk72	302	15	.	.	.
cord-001859-d62iuk72	303	1	(	(	-LRB-
cord-001859-d62iuk72	303	2	B	b	NN
cord-001859-d62iuk72	303	3	-	-	HYPH
cord-001859-d62iuk72	303	4	D	D	NNP
cord-001859-d62iuk72	303	5	)	)	-RRB-
cord-001859-d62iuk72	304	1	The	the	DT
cord-001859-d62iuk72	304	2	stability	stability	NN
cord-001859-d62iuk72	304	3	of	of	IN
cord-001859-d62iuk72	304	4	cellular	cellular	JJ
cord-001859-d62iuk72	304	5	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	304	6	,	,	,
cord-001859-d62iuk72	304	7	SRAG	SRAG	NNP
cord-001859-d62iuk72	304	8	and	and	CC
cord-001859-d62iuk72	304	9	H2A.1	H2A.1	NNP
cord-001859-d62iuk72	304	10	transcripts	transcript	NNS
cord-001859-d62iuk72	304	11	was	be	VBD
cord-001859-d62iuk72	304	12	determined	determine	VBN
cord-001859-d62iuk72	304	13	in	in	IN
cord-001859-d62iuk72	304	14	mRNA	mrna	NN
cord-001859-d62iuk72	304	15	decay	decay	NN
cord-001859-d62iuk72	304	16	assays	assay	NNS
cord-001859-d62iuk72	304	17	using	use	VBG
cord-001859-d62iuk72	304	18	actinomycin	actinomycin	NNS
cord-001859-d62iuk72	304	19	D	D	NNP
cord-001859-d62iuk72	304	20	(	(	-LRB-
cord-001859-d62iuk72	304	21	AcD	AcD	NNP
cord-001859-d62iuk72	304	22	)	)	-RRB-
cord-001859-d62iuk72	304	23	(	(	-LRB-
cord-001859-d62iuk72	304	24	10	10	CD
cord-001859-d62iuk72	304	25	μg	μg	NN
cord-001859-d62iuk72	304	26	/	/	SYM
cord-001859-d62iuk72	304	27	ml	ml	NN
cord-001859-d62iuk72	304	28	)	)	-RRB-
cord-001859-d62iuk72	304	29	or	or	CC
cord-001859-d62iuk72	304	30	control	control	VB
cord-001859-d62iuk72	304	31	DMSO	DMSO	NNP
cord-001859-d62iuk72	304	32	(	(	-LRB-
cord-001859-d62iuk72	304	33	1	1	CD
cord-001859-d62iuk72	304	34	%	%	NN
cord-001859-d62iuk72	304	35	)	)	-RRB-
cord-001859-d62iuk72	304	36	in	in	IN
cord-001859-d62iuk72	304	37	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	304	38	T	t	NN
cord-001859-d62iuk72	304	39	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	304	40	cells	cell	NNS
cord-001859-d62iuk72	304	41	.	.	.
cord-001859-d62iuk72	305	1	Cells	cell	NNS
cord-001859-d62iuk72	305	2	were	be	VBD
cord-001859-d62iuk72	305	3	collected	collect	VBN
cord-001859-d62iuk72	305	4	over	over	IN
cord-001859-d62iuk72	305	5	the	the	DT
cord-001859-d62iuk72	305	6	time	time	NN
cord-001859-d62iuk72	305	7	points	point	NNS
cord-001859-d62iuk72	305	8	indicated	indicate	VBN
cord-001859-d62iuk72	305	9	and	and	CC
cord-001859-d62iuk72	305	10	total	total	JJ
cord-001859-d62iuk72	305	11	RNA	RNA	NNP
cord-001859-d62iuk72	305	12	was	be	VBD
cord-001859-d62iuk72	305	13	extracted	extract	VBN
cord-001859-d62iuk72	305	14	followed	follow	VBN
cord-001859-d62iuk72	305	15	by	by	IN
cord-001859-d62iuk72	305	16	qRT	qRT	NNP
cord-001859-d62iuk72	305	17	-	-	HYPH
cord-001859-d62iuk72	305	18	PCR	PCR	NNP
cord-001859-d62iuk72	305	19	.	.	.
cord-001859-d62iuk72	306	1	The	the	DT
cord-001859-d62iuk72	306	2	average	average	NN
cord-001859-d62iuk72	306	3	of	of	IN
cord-001859-d62iuk72	306	4	two	two	CD
cord-001859-d62iuk72	306	5	biological	biological	JJ
cord-001859-d62iuk72	306	6	replicates	replicate	NNS
cord-001859-d62iuk72	306	7	with	with	IN
cord-001859-d62iuk72	306	8	error	error	NN
cord-001859-d62iuk72	306	9	bar	bar	NN
cord-001859-d62iuk72	306	10	as	as	IN
cord-001859-d62iuk72	306	11	standard	standard	JJ
cord-001859-d62iuk72	306	12	deviation	deviation	NN
cord-001859-d62iuk72	306	13	is	be	VBZ
cord-001859-d62iuk72	306	14	shown	show	VBN
cord-001859-d62iuk72	306	15	.	.	.
cord-001859-d62iuk72	307	1	(	(	-LRB-
cord-001859-d62iuk72	307	2	B	b	NN
cord-001859-d62iuk72	307	3	)	)	-RRB-
cord-001859-d62iuk72	307	4	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	307	5	transcripts	transcript	NNS
cord-001859-d62iuk72	307	6	were	be	VBD
cord-001859-d62iuk72	307	7	very	very	RB
cord-001859-d62iuk72	307	8	stable	stable	JJ
cord-001859-d62iuk72	307	9	,	,	,
cord-001859-d62iuk72	307	10	with	with	IN
cord-001859-d62iuk72	307	11	no	no	DT
cord-001859-d62iuk72	307	12	significant	significant	JJ
cord-001859-d62iuk72	307	13	reduction	reduction	NN
cord-001859-d62iuk72	307	14	in	in	IN
cord-001859-d62iuk72	307	15	their	-PRON-	PRP$
cord-001859-d62iuk72	307	16	levels	level	NNS
cord-001859-d62iuk72	307	17	after	after	IN
cord-001859-d62iuk72	307	18	10	10	CD
cord-001859-d62iuk72	307	19	h	h	NN
cord-001859-d62iuk72	307	20	of	of	IN
cord-001859-d62iuk72	307	21	AcD	acd	JJ
cord-001859-d62iuk72	307	22	treatment	treatment	NN
cord-001859-d62iuk72	307	23	.	.	.
cord-001859-d62iuk72	308	1	(	(	-LRB-
cord-001859-d62iuk72	308	2	C	C	NNP
cord-001859-d62iuk72	308	3	)	)	-RRB-
cord-001859-d62iuk72	309	1	At	at	IN
cord-001859-d62iuk72	310	1	4	4	LS
cord-001859-d62iuk72	310	2	h	h	NN
cord-001859-d62iuk72	310	3	AcD	acd	NN
cord-001859-d62iuk72	310	4	treatment	treatment	NN
cord-001859-d62iuk72	310	5	SRAG	SRAG	NNP
cord-001859-d62iuk72	311	1	mRNA	mrna	NN
cord-001859-d62iuk72	311	2	levels	level	NNS
cord-001859-d62iuk72	311	3	were	be	VBD
cord-001859-d62iuk72	311	4	reduced	reduce	VBN
cord-001859-d62iuk72	311	5	by	by	IN
cord-001859-d62iuk72	311	6	50	50	CD
cord-001859-d62iuk72	311	7	%	%	NN
cord-001859-d62iuk72	311	8	showing	show	VBG
cord-001859-d62iuk72	311	9	a	a	DT
cord-001859-d62iuk72	311	10	relatively	relatively	RB
cord-001859-d62iuk72	311	11	short	short	JJ
cord-001859-d62iuk72	311	12	stability	stability	NN
cord-001859-d62iuk72	311	13	.	.	.
cord-001859-d62iuk72	312	1	(	(	-LRB-
cord-001859-d62iuk72	312	2	D	d	NN
cord-001859-d62iuk72	312	3	)	)	-RRB-
cord-001859-d62iuk72	313	1	H2A.1	H2A.1	NNP
cord-001859-d62iuk72	314	1	mRNA	mrna	NN
cord-001859-d62iuk72	314	2	levels	level	NNS
cord-001859-d62iuk72	314	3	were	be	VBD
cord-001859-d62iuk72	314	4	very	very	RB
cord-001859-d62iuk72	314	5	unstable	unstable	JJ
cord-001859-d62iuk72	314	6	,	,	,
cord-001859-d62iuk72	314	7	with	with	IN
cord-001859-d62iuk72	314	8	nearly	nearly	RB
cord-001859-d62iuk72	314	9	100	100	CD
cord-001859-d62iuk72	314	10	%	%	NN
cord-001859-d62iuk72	314	11	reduction	reduction	NN
cord-001859-d62iuk72	314	12	after	after	IN
cord-001859-d62iuk72	314	13	2	2	CD
cord-001859-d62iuk72	314	14	h	h	NN
cord-001859-d62iuk72	314	15	AcD	acd	NN
cord-001859-d62iuk72	314	16	treatment	treatment	NN
cord-001859-d62iuk72	314	17	.	.	.
cord-001859-d62iuk72	315	1	(	(	-LRB-
cord-001859-d62iuk72	315	2	E	E	NNP
cord-001859-d62iuk72	315	3	)	)	-RRB-
cord-001859-d62iuk72	315	4	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	315	5	transcript	transcript	NN
cord-001859-d62iuk72	315	6	levels	level	NNS
cord-001859-d62iuk72	315	7	remained	remain	VBD
cord-001859-d62iuk72	315	8	unchanged	unchanged	JJ
cord-001859-d62iuk72	315	9	following	follow	VBG
cord-001859-d62iuk72	315	10	24	24	CD
cord-001859-d62iuk72	315	11	h	h	NN
cord-001859-d62iuk72	315	12	VER-155008	ver-155008	NN
cord-001859-d62iuk72	315	13	treatment	treatment	NN
cord-001859-d62iuk72	315	14	in	in	IN
cord-001859-d62iuk72	315	15	reactivated	reactivate	VBN
cord-001859-d62iuk72	315	16	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	315	17	T	t	NN
cord-001859-d62iuk72	315	18	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	315	19	cells	cell	NNS
cord-001859-d62iuk72	315	20	.	.	.
cord-001859-d62iuk72	316	1	The	the	DT
cord-001859-d62iuk72	316	2	same	same	JJ
cord-001859-d62iuk72	316	3	samples	sample	NNS
cord-001859-d62iuk72	316	4	in	in	IN
cord-001859-d62iuk72	316	5	which	which	WDT
cord-001859-d62iuk72	316	6	viral	viral	JJ
cord-001859-d62iuk72	316	7	transcripts	transcript	NNS
cord-001859-d62iuk72	316	8	had	have	VBD
cord-001859-d62iuk72	316	9	been	be	VBN
cord-001859-d62iuk72	316	10	quantified	quantify	VBN
cord-001859-d62iuk72	316	11	were	be	VBD
cord-001859-d62iuk72	316	12	used	use	VBN
cord-001859-d62iuk72	316	13	to	to	TO
cord-001859-d62iuk72	316	14	plot	plot	VB
cord-001859-d62iuk72	316	15	all	all	DT
cord-001859-d62iuk72	316	16	C	c	NN
cord-001859-d62iuk72	316	17	T	t	NN
cord-001859-d62iuk72	316	18	values	value	NNS
cord-001859-d62iuk72	316	19	.	.	.
cord-001859-d62iuk72	317	1	(	(	-LRB-
cord-001859-d62iuk72	317	2	F	F	NNP
cord-001859-d62iuk72	317	3	)	)	-RRB-
cord-001859-d62iuk72	318	1	The	the	DT
cord-001859-d62iuk72	318	2	unstable	unstable	JJ
cord-001859-d62iuk72	318	3	cellular	cellular	JJ
cord-001859-d62iuk72	318	4	SRAG	srag	NN
cord-001859-d62iuk72	318	5	and	and	CC
cord-001859-d62iuk72	318	6	H2A.1	h2a.1	NN
cord-001859-d62iuk72	318	7	mRNAs	mRNAs	NNPS
cord-001859-d62iuk72	318	8	were	be	VBD
cord-001859-d62iuk72	318	9	not	not	RB
cord-001859-d62iuk72	318	10	significantly	significantly	RB
cord-001859-d62iuk72	318	11	decreased	decrease	VBN
cord-001859-d62iuk72	318	12	in	in	IN
cord-001859-d62iuk72	318	13	the	the	DT
cord-001859-d62iuk72	318	14	presence	presence	NN
cord-001859-d62iuk72	318	15	of	of	IN
cord-001859-d62iuk72	318	16	VER-155008	ver-155008	NN
cord-001859-d62iuk72	318	17	treatment	treatment	NN
cord-001859-d62iuk72	318	18	compared	compare	VBN
cord-001859-d62iuk72	318	19	with	with	IN
cord-001859-d62iuk72	318	20	DMSO	DMSO	NNP
cord-001859-d62iuk72	318	21	treatment	treatment	NN
cord-001859-d62iuk72	318	22	for	for	IN
cord-001859-d62iuk72	318	23	24	24	CD
cord-001859-d62iuk72	318	24	h	h	NN
cord-001859-d62iuk72	318	25	indicating	indicate	VBG
cord-001859-d62iuk72	318	26	that	that	IN
cord-001859-d62iuk72	318	27	cellular	cellular	JJ
cord-001859-d62iuk72	318	28	transcription	transcription	NN
cord-001859-d62iuk72	318	29	was	be	VBD
cord-001859-d62iuk72	318	30	not	not	RB
cord-001859-d62iuk72	318	31	compromised	compromise	VBN
cord-001859-d62iuk72	318	32	even	even	RB
cord-001859-d62iuk72	318	33	at	at	IN
cord-001859-d62iuk72	318	34	high	high	JJ
cord-001859-d62iuk72	318	35	concentrations	concentration	NNS
cord-001859-d62iuk72	318	36	of	of	IN
cord-001859-d62iuk72	318	37	VER-155008	ver-155008	NN
cord-001859-d62iuk72	318	38	.	.	.
cord-001859-d62iuk72	319	1	The	the	DT
cord-001859-d62iuk72	319	2	same	same	JJ
cord-001859-d62iuk72	319	3	samples	sample	NNS
cord-001859-d62iuk72	319	4	in	in	IN
cord-001859-d62iuk72	319	5	which	which	WDT
cord-001859-d62iuk72	319	6	viral	viral	JJ
cord-001859-d62iuk72	319	7	transcripts	transcript	NNS
cord-001859-d62iuk72	319	8	had	have	VBD
cord-001859-d62iuk72	319	9	been	be	VBN
cord-001859-d62iuk72	319	10	quantified	quantify	VBN
cord-001859-d62iuk72	319	11	were	be	VBD
cord-001859-d62iuk72	319	12	used	use	VBN
cord-001859-d62iuk72	319	13	to	to	TO
cord-001859-d62iuk72	319	14	quantify	quantify	VB
cord-001859-d62iuk72	319	15	SRAG	SRAG	NNP
cord-001859-d62iuk72	319	16	and	and	CC
cord-001859-d62iuk72	319	17	H2A.1	H2A.1	NNP
cord-001859-d62iuk72	319	18	.	.	.
cord-001859-d62iuk72	320	1	All	all	DT
cord-001859-d62iuk72	320	2	samples	sample	NNS
cord-001859-d62iuk72	320	3	were	be	VBD
cord-001859-d62iuk72	320	4	normalised	normalise	VBN
cord-001859-d62iuk72	320	5	to	to	IN
cord-001859-d62iuk72	320	6	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	320	7	.	.	.
cord-001859-d62iuk72	321	1	However	however	RB
cord-001859-d62iuk72	321	2	,	,	,
cord-001859-d62iuk72	321	3	no	no	DT
cord-001859-d62iuk72	321	4	significant	significant	JJ
cord-001859-d62iuk72	321	5	decrease	decrease	NN
cord-001859-d62iuk72	321	6	in	in	IN
cord-001859-d62iuk72	321	7	the	the	DT
cord-001859-d62iuk72	321	8	amount	amount	NN
cord-001859-d62iuk72	321	9	of	of	IN
cord-001859-d62iuk72	321	10	PAN	PAN	NNP
cord-001859-d62iuk72	321	11	RNA	RNA	NNP
cord-001859-d62iuk72	321	12	was	be	VBD
cord-001859-d62iuk72	321	13	seen	see	VBN
cord-001859-d62iuk72	321	14	in	in	IN
cord-001859-d62iuk72	321	15	inhibitor	inhibitor	NN
cord-001859-d62iuk72	321	16	-	-	HYPH
cord-001859-d62iuk72	321	17	treated	treat	VBN
cord-001859-d62iuk72	321	18	cells	cell	NNS
cord-001859-d62iuk72	321	19	(	(	-LRB-
cord-001859-d62iuk72	321	20	Fig	Fig	NNP
cord-001859-d62iuk72	321	21	7E	7E	NNP
cord-001859-d62iuk72	321	22	)	)	-RRB-
cord-001859-d62iuk72	321	23	,	,	,
cord-001859-d62iuk72	321	24	indicating	indicate	VBG
cord-001859-d62iuk72	321	25	that	that	IN
cord-001859-d62iuk72	321	26	RTA	RTA	NNP
cord-001859-d62iuk72	321	27	-	-	HYPH
cord-001859-d62iuk72	321	28	mediated	mediate	VBN
cord-001859-d62iuk72	321	29	promoter	promoter	NN
cord-001859-d62iuk72	321	30	transactivation	transactivation	NN
cord-001859-d62iuk72	321	31	and	and	CC
cord-001859-d62iuk72	321	32	subsequent	subsequent	JJ
cord-001859-d62iuk72	321	33	synthesis	synthesis	NN
cord-001859-d62iuk72	321	34	of	of	IN
cord-001859-d62iuk72	321	35	PAN	PAN	NNP
cord-001859-d62iuk72	321	36	RNA	RNA	NNP
cord-001859-d62iuk72	321	37	was	be	VBD
cord-001859-d62iuk72	321	38	occurring	occur	VBG
cord-001859-d62iuk72	321	39	normally	normally	RB
cord-001859-d62iuk72	321	40	in	in	IN
cord-001859-d62iuk72	321	41	the	the	DT
cord-001859-d62iuk72	321	42	presence	presence	NN
cord-001859-d62iuk72	321	43	of	of	IN
cord-001859-d62iuk72	321	44	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	321	45	.	.	.
cord-001859-d62iuk72	322	1	These	these	DT
cord-001859-d62iuk72	322	2	data	datum	NNS
cord-001859-d62iuk72	322	3	demonstrate	demonstrate	VBP
cord-001859-d62iuk72	322	4	that	that	IN
cord-001859-d62iuk72	322	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	322	6	isoforms	isoform	NNS
cord-001859-d62iuk72	322	7	did	do	VBD
cord-001859-d62iuk72	322	8	not	not	RB
cord-001859-d62iuk72	322	9	directly	directly	RB
cord-001859-d62iuk72	322	10	enhance	enhance	VB
cord-001859-d62iuk72	322	11	RTA	RTA	NNP
cord-001859-d62iuk72	322	12	-	-	HYPH
cord-001859-d62iuk72	322	13	mediated	mediate	VBN
cord-001859-d62iuk72	322	14	transactivation	transactivation	NN
cord-001859-d62iuk72	322	15	.	.	.
cord-001859-d62iuk72	323	1	To	to	TO
cord-001859-d62iuk72	323	2	assess	assess	VB
cord-001859-d62iuk72	323	3	the	the	DT
cord-001859-d62iuk72	323	4	transcription	transcription	NN
cord-001859-d62iuk72	323	5	activity	activity	NN
cord-001859-d62iuk72	323	6	of	of	IN
cord-001859-d62iuk72	323	7	cellular	cellular	JJ
cord-001859-d62iuk72	323	8	RNAPII	rnapii	NN
cord-001859-d62iuk72	323	9	in	in	IN
cord-001859-d62iuk72	323	10	the	the	DT
cord-001859-d62iuk72	323	11	presence	presence	NN
cord-001859-d62iuk72	323	12	of	of	IN
cord-001859-d62iuk72	323	13	the	the	DT
cord-001859-d62iuk72	323	14	inhibitor	inhibitor	NN
cord-001859-d62iuk72	323	15	,	,	,
cord-001859-d62iuk72	323	16	the	the	DT
cord-001859-d62iuk72	323	17	half	half	JJ
cord-001859-d62iuk72	323	18	-	-	HYPH
cord-001859-d62iuk72	323	19	life	life	NN
cord-001859-d62iuk72	323	20	of	of	IN
cord-001859-d62iuk72	323	21	PAN	PAN	NNP
cord-001859-d62iuk72	323	22	RNA	RNA	NNP
cord-001859-d62iuk72	323	23	was	be	VBD
cord-001859-d62iuk72	323	24	determined	determine	VBN
cord-001859-d62iuk72	323	25	in	in	IN
cord-001859-d62iuk72	323	26	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	323	27	T	T	NNP
cord-001859-d62iuk72	323	28	cells	cell	NNS
cord-001859-d62iuk72	323	29	co	co	VBD
cord-001859-d62iuk72	323	30	-	-	VBN
cord-001859-d62iuk72	323	31	transfected	transfecte	VBN
cord-001859-d62iuk72	323	32	with	with	IN
cord-001859-d62iuk72	323	33	pPAN	ppan	JJ
cord-001859-d62iuk72	323	34	-	-	HYPH
cord-001859-d62iuk72	323	35	WT	wt	NN
cord-001859-d62iuk72	323	36	and	and	CC
cord-001859-d62iuk72	323	37	pRTA	prta	JJ
cord-001859-d62iuk72	323	38	-	-	JJ
cord-001859-d62iuk72	323	39	EGFP	EGFP	NNP
cord-001859-d62iuk72	323	40	.	.	.
cord-001859-d62iuk72	324	1	Following	follow	VBG
cord-001859-d62iuk72	324	2	24	24	CD
cord-001859-d62iuk72	324	3	h	h	NN
cord-001859-d62iuk72	324	4	post	post	NN
cord-001859-d62iuk72	324	5	-	-	NN
cord-001859-d62iuk72	324	6	transfection	transfection	JJ
cord-001859-d62iuk72	324	7	,	,	,
cord-001859-d62iuk72	324	8	AcD	AcD	NNP
cord-001859-d62iuk72	324	9	(	(	-LRB-
cord-001859-d62iuk72	324	10	5	5	CD
cord-001859-d62iuk72	324	11	μg	μg	NN
cord-001859-d62iuk72	324	12	/	/	SYM
cord-001859-d62iuk72	324	13	ml	ml	NNP
cord-001859-d62iuk72	324	14	)	)	-RRB-
cord-001859-d62iuk72	324	15	or	or	CC
cord-001859-d62iuk72	324	16	DMSO	DMSO	NNP
cord-001859-d62iuk72	324	17	control	control	NN
cord-001859-d62iuk72	324	18	(	(	-LRB-
cord-001859-d62iuk72	324	19	0.5	0.5	CD
cord-001859-d62iuk72	324	20	%	%	NN
cord-001859-d62iuk72	324	21	)	)	-RRB-
cord-001859-d62iuk72	324	22	was	be	VBD
cord-001859-d62iuk72	324	23	added	add	VBN
cord-001859-d62iuk72	324	24	.	.	.
cord-001859-d62iuk72	325	1	After	after	IN
cord-001859-d62iuk72	325	2	7	7	CD
cord-001859-d62iuk72	325	3	h	h	NN
cord-001859-d62iuk72	325	4	of	of	IN
cord-001859-d62iuk72	325	5	transcription	transcription	NN
cord-001859-d62iuk72	325	6	inhibition	inhibition	NN
cord-001859-d62iuk72	325	7	,	,	,
cord-001859-d62iuk72	325	8	PAN	PAN	NNP
cord-001859-d62iuk72	325	9	RNA	RNA	NNP
cord-001859-d62iuk72	325	10	levels	level	NNS
cord-001859-d62iuk72	325	11	were	be	VBD
cord-001859-d62iuk72	325	12	reduced	reduce	VBN
cord-001859-d62iuk72	325	13	to	to	IN
cord-001859-d62iuk72	325	14	25	25	CD
cord-001859-d62iuk72	325	15	%	%	NN
cord-001859-d62iuk72	325	16	compared	compare	VBN
cord-001859-d62iuk72	325	17	to	to	IN
cord-001859-d62iuk72	325	18	DMSO	DMSO	NNP
cord-001859-d62iuk72	325	19	-	-	HYPH
cord-001859-d62iuk72	325	20	treated	treat	VBN
cord-001859-d62iuk72	325	21	cells	cell	NNS
cord-001859-d62iuk72	325	22	(	(	-LRB-
cord-001859-d62iuk72	325	23	Fig	Fig	NNP
cord-001859-d62iuk72	325	24	7F	7f	NN
cord-001859-d62iuk72	325	25	)	)	-RRB-
cord-001859-d62iuk72	325	26	.	.	.
cord-001859-d62iuk72	326	1	This	this	DT
cord-001859-d62iuk72	326	2	quick	quick	JJ
cord-001859-d62iuk72	326	3	reduction	reduction	NN
cord-001859-d62iuk72	326	4	in	in	IN
cord-001859-d62iuk72	326	5	the	the	DT
cord-001859-d62iuk72	326	6	stability	stability	NN
cord-001859-d62iuk72	326	7	of	of	IN
cord-001859-d62iuk72	326	8	PAN	PAN	NNP
cord-001859-d62iuk72	326	9	RNA	RNA	NNP
cord-001859-d62iuk72	326	10	in	in	IN
cord-001859-d62iuk72	326	11	the	the	DT
cord-001859-d62iuk72	326	12	absence	absence	NN
cord-001859-d62iuk72	326	13	of	of	IN
cord-001859-d62iuk72	326	14	ORF57	ORF57	NNP
cord-001859-d62iuk72	326	15	protein	protein	NN
cord-001859-d62iuk72	326	16	is	be	VBZ
cord-001859-d62iuk72	326	17	in	in	IN
cord-001859-d62iuk72	326	18	agreement	agreement	NN
cord-001859-d62iuk72	326	19	with	with	IN
cord-001859-d62iuk72	326	20	previous	previous	JJ
cord-001859-d62iuk72	326	21	reports	report	NNS
cord-001859-d62iuk72	326	22	[	[	-LRB-
cord-001859-d62iuk72	326	23	72	72	CD
cord-001859-d62iuk72	326	24	]	]	-RRB-
cord-001859-d62iuk72	326	25	.	.	.
cord-001859-d62iuk72	327	1	Thus	thus	RB
cord-001859-d62iuk72	327	2	,	,	,
cord-001859-d62iuk72	327	3	if	if	IN
cord-001859-d62iuk72	327	4	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	327	5	was	be	VBD
cord-001859-d62iuk72	327	6	blocking	block	VBG
cord-001859-d62iuk72	327	7	general	general	JJ
cord-001859-d62iuk72	327	8	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	327	9	transcription	transcription	NN
cord-001859-d62iuk72	327	10	,	,	,
cord-001859-d62iuk72	327	11	a	a	DT
cord-001859-d62iuk72	327	12	significant	significant	JJ
cord-001859-d62iuk72	327	13	reduction	reduction	NN
cord-001859-d62iuk72	327	14	in	in	IN
cord-001859-d62iuk72	327	15	PAN	PAN	NNP
cord-001859-d62iuk72	327	16	RNA	RNA	NNP
cord-001859-d62iuk72	327	17	levels	level	NNS
cord-001859-d62iuk72	327	18	should	should	MD
cord-001859-d62iuk72	327	19	be	be	VB
cord-001859-d62iuk72	327	20	observed	observe	VBN
cord-001859-d62iuk72	327	21	after	after	IN
cord-001859-d62iuk72	327	22	7	7	CD
cord-001859-d62iuk72	327	23	h	h	NN
cord-001859-d62iuk72	327	24	of	of	IN
cord-001859-d62iuk72	327	25	inhibitor	inhibitor	NN
cord-001859-d62iuk72	327	26	treatment	treatment	NN
cord-001859-d62iuk72	327	27	;	;	:
cord-001859-d62iuk72	327	28	however	however	RB
cord-001859-d62iuk72	327	29	,	,	,
cord-001859-d62iuk72	327	30	PAN	PAN	NNP
cord-001859-d62iuk72	327	31	RNA	RNA	NNP
cord-001859-d62iuk72	327	32	levels	level	NNS
cord-001859-d62iuk72	327	33	were	be	VBD
cord-001859-d62iuk72	327	34	not	not	RB
cord-001859-d62iuk72	327	35	reduced	reduce	VBN
cord-001859-d62iuk72	327	36	in	in	IN
cord-001859-d62iuk72	327	37	cells	cell	NNS
cord-001859-d62iuk72	327	38	treated	treat	VBN
cord-001859-d62iuk72	327	39	with	with	IN
cord-001859-d62iuk72	327	40	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	327	41	for	for	IN
cord-001859-d62iuk72	327	42	24	24	CD
cord-001859-d62iuk72	327	43	h	h	NN
cord-001859-d62iuk72	327	44	(	(	-LRB-
cord-001859-d62iuk72	327	45	Fig	Fig	NNP
cord-001859-d62iuk72	327	46	7E	7E	NNP
cord-001859-d62iuk72	327	47	)	)	-RRB-
cord-001859-d62iuk72	327	48	.	.	.
cord-001859-d62iuk72	328	1	A	a	DT
cord-001859-d62iuk72	328	2	dramatic	dramatic	JJ
cord-001859-d62iuk72	328	3	reduction	reduction	NN
cord-001859-d62iuk72	328	4	in	in	IN
cord-001859-d62iuk72	328	5	early	early	JJ
cord-001859-d62iuk72	328	6	,	,	,
cord-001859-d62iuk72	328	7	late	late	JJ
cord-001859-d62iuk72	328	8	and	and	CC
cord-001859-d62iuk72	328	9	ori	ori	JJ
cord-001859-d62iuk72	328	10	-	-	HYPH
cord-001859-d62iuk72	328	11	Lyt	Lyt	NNP
cord-001859-d62iuk72	328	12	transcripts	transcript	NNS
cord-001859-d62iuk72	328	13	after	after	IN
cord-001859-d62iuk72	328	14	24	24	CD
cord-001859-d62iuk72	328	15	h	h	NN
cord-001859-d62iuk72	328	16	treatment	treatment	NN
cord-001859-d62iuk72	328	17	with	with	IN
cord-001859-d62iuk72	328	18	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	328	19	was	be	VBD
cord-001859-d62iuk72	328	20	evident	evident	JJ
cord-001859-d62iuk72	328	21	during	during	IN
cord-001859-d62iuk72	328	22	KSHV	KSHV	NNP
cord-001859-d62iuk72	328	23	infection	infection	NN
cord-001859-d62iuk72	328	24	in	in	IN
cord-001859-d62iuk72	328	25	both	both	DT
cord-001859-d62iuk72	328	26	cell	cell	NN
cord-001859-d62iuk72	328	27	lines	line	NNS
cord-001859-d62iuk72	328	28	used	use	VBN
cord-001859-d62iuk72	328	29	.	.	.
cord-001859-d62iuk72	329	1	However	however	RB
cord-001859-d62iuk72	329	2	,	,	,
cord-001859-d62iuk72	329	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	329	4	isoforms	isoform	NNS
cord-001859-d62iuk72	329	5	were	be	VBD
cord-001859-d62iuk72	329	6	not	not	RB
cord-001859-d62iuk72	329	7	required	require	VBN
cord-001859-d62iuk72	329	8	for	for	IN
cord-001859-d62iuk72	329	9	RTA	RTA	NNP
cord-001859-d62iuk72	329	10	-	-	HYPH
cord-001859-d62iuk72	329	11	mediated	mediate	VBN
cord-001859-d62iuk72	329	12	transactivation	transactivation	NN
cord-001859-d62iuk72	329	13	of	of	IN
cord-001859-d62iuk72	329	14	KSHV	KSHV	NNP
cord-001859-d62iuk72	329	15	promoters	promoter	NNS
cord-001859-d62iuk72	329	16	in	in	IN
cord-001859-d62iuk72	329	17	transiently	transiently	RB
cord-001859-d62iuk72	329	18	transfected	transfecte	VBN
cord-001859-d62iuk72	329	19	cells	cell	NNS
cord-001859-d62iuk72	329	20	.	.	.
cord-001859-d62iuk72	330	1	Thus	thus	RB
cord-001859-d62iuk72	330	2	,	,	,
cord-001859-d62iuk72	330	3	we	-PRON-	PRP
cord-001859-d62iuk72	330	4	next	next	RB
cord-001859-d62iuk72	330	5	monitored	monitor	VBD
cord-001859-d62iuk72	330	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	330	7	RTC	RTC	NNP
cord-001859-d62iuk72	330	8	formation	formation	NN
cord-001859-d62iuk72	330	9	in	in	IN
cord-001859-d62iuk72	330	10	the	the	DT
cord-001859-d62iuk72	330	11	absence	absence	NN
cord-001859-d62iuk72	330	12	or	or	CC
cord-001859-d62iuk72	330	13	presence	presence	NN
cord-001859-d62iuk72	330	14	of	of	IN
cord-001859-d62iuk72	330	15	the	the	DT
cord-001859-d62iuk72	330	16	inhibitor	inhibitor	NN
cord-001859-d62iuk72	330	17	during	during	IN
cord-001859-d62iuk72	330	18	KSHV	KSHV	NNP
cord-001859-d62iuk72	330	19	lytic	lytic	JJ
cord-001859-d62iuk72	330	20	infection	infection	NN
cord-001859-d62iuk72	330	21	.	.	.
cord-001859-d62iuk72	331	1	TREx	TREx	NNP
cord-001859-d62iuk72	331	2	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	331	3	cells	cell	NNS
cord-001859-d62iuk72	331	4	were	be	VBD
cord-001859-d62iuk72	331	5	reactivated	reactivate	VBN
cord-001859-d62iuk72	331	6	and	and	CC
cord-001859-d62iuk72	331	7	treated	treat	VBN
cord-001859-d62iuk72	331	8	with	with	IN
cord-001859-d62iuk72	331	9	either	either	DT
cord-001859-d62iuk72	331	10	control	control	NN
cord-001859-d62iuk72	331	11	DMSO	DMSO	NNP
cord-001859-d62iuk72	331	12	or	or	CC
cord-001859-d62iuk72	331	13	2	2	CD
cord-001859-d62iuk72	331	14	μM	μm	CD
cord-001859-d62iuk72	331	15	inhibitor	inhibitor	NN
cord-001859-d62iuk72	331	16	.	.	.
cord-001859-d62iuk72	332	1	At	at	IN
cord-001859-d62iuk72	332	2	24	24	CD
cord-001859-d62iuk72	332	3	h	h	NN
cord-001859-d62iuk72	332	4	reactivation	reactivation	NN
cord-001859-d62iuk72	332	5	cells	cell	NNS
cord-001859-d62iuk72	332	6	were	be	VBD
cord-001859-d62iuk72	332	7	fixed	fix	VBN
cord-001859-d62iuk72	332	8	and	and	CC
cord-001859-d62iuk72	332	9	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	332	10	was	be	VBD
cord-001859-d62iuk72	332	11	performed	perform	VBN
cord-001859-d62iuk72	332	12	using	use	VBG
cord-001859-d62iuk72	332	13	RTA	RTA	NNP
cord-001859-d62iuk72	332	14	-	-	:
cord-001859-d62iuk72	332	15	and	and	CC
cord-001859-d62iuk72	332	16	Hsc70-specific	hsc70-specific	NN
cord-001859-d62iuk72	332	17	antibodies	antibody	NNS
cord-001859-d62iuk72	332	18	.	.	.
cord-001859-d62iuk72	333	1	DMSO	DMSO	NNP
cord-001859-d62iuk72	333	2	-	-	HYPH
cord-001859-d62iuk72	333	3	treated	treat	VBN
cord-001859-d62iuk72	333	4	cells	cell	NNS
cord-001859-d62iuk72	333	5	displayed	display	VBD
cord-001859-d62iuk72	333	6	abundant	abundant	JJ
cord-001859-d62iuk72	333	7	RTCs	rtc	NNS
cord-001859-d62iuk72	333	8	and	and	CC
cord-001859-d62iuk72	333	9	numerous	numerous	JJ
cord-001859-d62iuk72	333	10	nuclear	nuclear	JJ
cord-001859-d62iuk72	333	11	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	333	12	foci	focus	NNS
cord-001859-d62iuk72	333	13	that	that	WDT
cord-001859-d62iuk72	333	14	partially	partially	RB
cord-001859-d62iuk72	333	15	co	co	VBD
cord-001859-d62iuk72	333	16	-	-	VBN
cord-001859-d62iuk72	333	17	localised	localised	JJ
cord-001859-d62iuk72	333	18	with	with	IN
cord-001859-d62iuk72	333	19	RTCs	rtc	NNS
cord-001859-d62iuk72	333	20	.	.	.
cord-001859-d62iuk72	334	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	334	2	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	334	3	depletion	depletion	NN
cord-001859-d62iuk72	334	4	was	be	VBD
cord-001859-d62iuk72	334	5	also	also	RB
cord-001859-d62iuk72	334	6	observed	observe	VBN
cord-001859-d62iuk72	334	7	(	(	-LRB-
cord-001859-d62iuk72	334	8	Fig	Fig	NNP
cord-001859-d62iuk72	334	9	8A	8a	NN
cord-001859-d62iuk72	334	10	and	and	CC
cord-001859-d62iuk72	334	11	8A	8a	NN
cord-001859-d62iuk72	334	12	'	'	''
cord-001859-d62iuk72	334	13	)	)	-RRB-
cord-001859-d62iuk72	334	14	.	.	.
cord-001859-d62iuk72	335	1	In	in	IN
cord-001859-d62iuk72	335	2	contrast	contrast	NN
cord-001859-d62iuk72	335	3	,	,	,
cord-001859-d62iuk72	335	4	inhibitortreated	inhibitortreate	VBN
cord-001859-d62iuk72	335	5	cells	cell	NNS
cord-001859-d62iuk72	335	6	showed	show	VBD
cord-001859-d62iuk72	335	7	diffuse	diffuse	JJ
cord-001859-d62iuk72	335	8	nuclear	nuclear	JJ
cord-001859-d62iuk72	335	9	RTA	RTA	NNP
cord-001859-d62iuk72	335	10	that	that	WDT
cord-001859-d62iuk72	335	11	was	be	VBD
cord-001859-d62iuk72	335	12	not	not	RB
cord-001859-d62iuk72	335	13	able	able	JJ
cord-001859-d62iuk72	335	14	to	to	TO
cord-001859-d62iuk72	335	15	assemble	assemble	VB
cord-001859-d62iuk72	335	16	into	into	IN
cord-001859-d62iuk72	335	17	RTCs	rtc	NNS
cord-001859-d62iuk72	335	18	(	(	-LRB-
cord-001859-d62iuk72	335	19	Fig	fig	NN
cord-001859-d62iuk72	335	20	8B	8b	NN
cord-001859-d62iuk72	335	21	and	and	CC
cord-001859-d62iuk72	335	22	 	 	_SP
cord-001859-d62iuk72	335	23	8B	8B	NNP
cord-001859-d62iuk72	335	24	'	'	''
cord-001859-d62iuk72	335	25	)	)	-RRB-
cord-001859-d62iuk72	335	26	.	.	.
cord-001859-d62iuk72	336	1	In	in	IN
cord-001859-d62iuk72	336	2	these	these	DT
cord-001859-d62iuk72	336	3	cells	cell	NNS
cord-001859-d62iuk72	336	4	,	,	,
cord-001859-d62iuk72	336	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	336	6	nuclear	nuclear	JJ
cord-001859-d62iuk72	336	7	foci	focus	NNS
cord-001859-d62iuk72	336	8	were	be	VBD
cord-001859-d62iuk72	336	9	still	still	RB
cord-001859-d62iuk72	336	10	visible	visible	JJ
cord-001859-d62iuk72	336	11	,	,	,
cord-001859-d62iuk72	336	12	but	but	CC
cord-001859-d62iuk72	336	13	these	these	DT
cord-001859-d62iuk72	336	14	were	be	VBD
cord-001859-d62iuk72	336	15	much	much	RB
cord-001859-d62iuk72	336	16	less	less	RBR
cord-001859-d62iuk72	336	17	numerous	numerous	JJ
cord-001859-d62iuk72	336	18	and	and	CC
cord-001859-d62iuk72	336	19	smaller	small	JJR
cord-001859-d62iuk72	336	20	compared	compare	VBN
cord-001859-d62iuk72	336	21	with	with	IN
cord-001859-d62iuk72	336	22	the	the	DT
cord-001859-d62iuk72	336	23	foci	foci	NN
cord-001859-d62iuk72	336	24	seen	see	VBN
cord-001859-d62iuk72	336	25	in	in	IN
cord-001859-d62iuk72	336	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	336	27	-	-	HYPH
cord-001859-d62iuk72	336	28	treated	treat	VBN
cord-001859-d62iuk72	336	29	cells	cell	NNS
cord-001859-d62iuk72	336	30	.	.	.
cord-001859-d62iuk72	337	1	Significantly	significantly	RB
cord-001859-d62iuk72	337	2	,	,	,
cord-001859-d62iuk72	337	3	following	follow	VBG
cord-001859-d62iuk72	337	4	VER-155008	ver-155008	NN
cord-001859-d62iuk72	337	5	treatment	treatment	NN
cord-001859-d62iuk72	337	6	,	,	,
cord-001859-d62iuk72	337	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	337	8	was	be	VBD
cord-001859-d62iuk72	337	9	observed	observe	VBN
cord-001859-d62iuk72	337	10	in	in	IN
cord-001859-d62iuk72	337	11	the	the	DT
cord-001859-d62iuk72	337	12	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	337	13	of	of	IN
cord-001859-d62iuk72	337	14	reactivated	reactivate	VBN
cord-001859-d62iuk72	337	15	cells	cell	NNS
cord-001859-d62iuk72	337	16	(	(	-LRB-
cord-001859-d62iuk72	337	17	Fig	Fig	NNP
cord-001859-d62iuk72	337	18	8B	8b	NN
cord-001859-d62iuk72	337	19	and	and	CC
cord-001859-d62iuk72	337	20	 	 	_SP
cord-001859-d62iuk72	337	21	8B	8B	NNP
cord-001859-d62iuk72	337	22	'	'	''
cord-001859-d62iuk72	337	23	)	)	-RRB-
cord-001859-d62iuk72	337	24	.	.	.
cord-001859-d62iuk72	338	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	339	1	subcellular	subcellular	JJ
cord-001859-d62iuk72	339	2	localization	localization	NN
cord-001859-d62iuk72	339	3	was	be	VBD
cord-001859-d62iuk72	339	4	also	also	RB
cord-001859-d62iuk72	339	5	analysed	analyse	VBN
cord-001859-d62iuk72	339	6	in	in	IN
cord-001859-d62iuk72	339	7	DMSO	DMSO	NNP
cord-001859-d62iuk72	339	8	-	-	:
cord-001859-d62iuk72	339	9	and	and	CC
cord-001859-d62iuk72	339	10	inhibitor	inhibitor	NN
cord-001859-d62iuk72	339	11	-	-	HYPH
cord-001859-d62iuk72	339	12	treated	treat	VBN
cord-001859-d62iuk72	339	13	cells	cell	NNS
cord-001859-d62iuk72	339	14	by	by	IN
cord-001859-d62iuk72	339	15	confocal	confocal	JJ
cord-001859-d62iuk72	339	16	profiling	profiling	NN
cord-001859-d62iuk72	339	17	.	.	.
cord-001859-d62iuk72	340	1	Profiling	profiling	NN
cord-001859-d62iuk72	340	2	was	be	VBD
cord-001859-d62iuk72	340	3	performed	perform	VBN
cord-001859-d62iuk72	340	4	by	by	IN
cord-001859-d62iuk72	340	5	drawing	draw	VBG
cord-001859-d62iuk72	340	6	a	a	DT
cord-001859-d62iuk72	340	7	line	line	NN
cord-001859-d62iuk72	340	8	long	long	RB
cord-001859-d62iuk72	340	9	enough	enough	RB
cord-001859-d62iuk72	340	10	(	(	-LRB-
cord-001859-d62iuk72	340	11	~20	~20	NFP
cord-001859-d62iuk72	340	12	μm	μm	NN
cord-001859-d62iuk72	340	13	)	)	-RRB-
cord-001859-d62iuk72	340	14	to	to	TO
cord-001859-d62iuk72	340	15	cover	cover	VB
cord-001859-d62iuk72	340	16	the	the	DT
cord-001859-d62iuk72	340	17	nucleus	nucleus	NN
cord-001859-d62iuk72	340	18	and	and	CC
cord-001859-d62iuk72	340	19	cytoplasm	cytoplasm	JJ
cord-001859-d62iuk72	340	20	at	at	IN
cord-001859-d62iuk72	340	21	either	either	DT
cord-001859-d62iuk72	340	22	side	side	NN
cord-001859-d62iuk72	340	23	of	of	IN
cord-001859-d62iuk72	340	24	the	the	DT
cord-001859-d62iuk72	340	25	nucleus	nucleus	NN
cord-001859-d62iuk72	340	26	.	.	.
cord-001859-d62iuk72	341	1	If	if	IN
cord-001859-d62iuk72	341	2	an	an	DT
cord-001859-d62iuk72	341	3	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	341	4	pixel	pixel	NN
cord-001859-d62iuk72	341	5	intensity	intensity	NN
cord-001859-d62iuk72	341	6	data	datum	NNS
cord-001859-d62iuk72	341	7	point	point	NN
cord-001859-d62iuk72	341	8	was	be	VBD
cord-001859-d62iuk72	341	9	equal	equal	JJ
cord-001859-d62iuk72	341	10	or	or	CC
cord-001859-d62iuk72	341	11	greater	great	JJR
cord-001859-d62iuk72	341	12	than	than	IN
cord-001859-d62iuk72	341	13	to	to	IN
cord-001859-d62iuk72	341	14	the	the	DT
cord-001859-d62iuk72	341	15	data	data	NN
cord-001859-d62iuk72	341	16	point	point	NN
cord-001859-d62iuk72	341	17	in	in	IN
cord-001859-d62iuk72	341	18	the	the	DT
cord-001859-d62iuk72	341	19	previous	previous	JJ
cord-001859-d62iuk72	341	20	and	and	CC
cord-001859-d62iuk72	341	21	subsequent	subsequent	JJ
cord-001859-d62iuk72	341	22	pixel	pixel	NN
cord-001859-d62iuk72	341	23	and	and	CC
cord-001859-d62iuk72	341	24	above	above	IN
cord-001859-d62iuk72	341	25	the	the	DT
cord-001859-d62iuk72	341	26	background	background	NN
cord-001859-d62iuk72	341	27	noise	noise	NN
cord-001859-d62iuk72	341	28	,	,	,
cord-001859-d62iuk72	341	29	it	-PRON-	PRP
cord-001859-d62iuk72	341	30	was	be	VBD
cord-001859-d62iuk72	341	31	considered	consider	VBN
cord-001859-d62iuk72	341	32	as	as	IN
cord-001859-d62iuk72	341	33	an	an	DT
cord-001859-d62iuk72	341	34	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	341	35	peak	peak	NN
cord-001859-d62iuk72	341	36	,	,	,
cord-001859-d62iuk72	341	37	representing	represent	VBG
cord-001859-d62iuk72	341	38	an	an	DT
cord-001859-d62iuk72	341	39	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	341	40	foci	foci	NN
cord-001859-d62iuk72	341	41	.	.	.
cord-001859-d62iuk72	342	1	analysed	analyse	VBN
cord-001859-d62iuk72	342	2	by	by	IN
cord-001859-d62iuk72	342	3	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	342	4	.	.	.
cord-001859-d62iuk72	343	1	Endogenous	endogenous	JJ
cord-001859-d62iuk72	343	2	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	343	3	was	be	VBD
cord-001859-d62iuk72	343	4	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	343	5	in	in	IN
cord-001859-d62iuk72	343	6	cells	cell	NNS
cord-001859-d62iuk72	343	7	expressing	express	VBG
cord-001859-d62iuk72	343	8	EGFP	EGFP	NNP
cord-001859-d62iuk72	343	9	(	(	-LRB-
cord-001859-d62iuk72	343	10	i	i	NN
cord-001859-d62iuk72	343	11	)	)	-RRB-
cord-001859-d62iuk72	343	12	.	.	.
cord-001859-d62iuk72	344	1	In	in	IN
cord-001859-d62iuk72	344	2	contrast	contrast	NN
cord-001859-d62iuk72	344	3	,	,	,
cord-001859-d62iuk72	344	4	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	344	5	strongly	strongly	RB
cord-001859-d62iuk72	344	6	co	co	VBZ
cord-001859-d62iuk72	344	7	-	-	JJ
cord-001859-d62iuk72	344	8	localised	localised	JJ
cord-001859-d62iuk72	344	9	with	with	IN
cord-001859-d62iuk72	344	10	EGFP	EGFP	NNP
cord-001859-d62iuk72	344	11	-	-	HYPH
cord-001859-d62iuk72	344	12	RTA	RTA	NNP
cord-001859-d62iuk72	344	13	in	in	IN
cord-001859-d62iuk72	344	14	the	the	DT
cord-001859-d62iuk72	344	15	nucleus	nucleus	NN
cord-001859-d62iuk72	344	16	,	,	,
cord-001859-d62iuk72	344	17	but	but	CC
cord-001859-d62iuk72	344	18	not	not	RB
cord-001859-d62iuk72	344	19	the	the	DT
cord-001859-d62iuk72	344	20	nucleoli	nucleoli	NNP
cord-001859-d62iuk72	344	21	(	(	-LRB-
cord-001859-d62iuk72	344	22	ii	ii	NNP
cord-001859-d62iuk72	344	23	)	)	-RRB-
cord-001859-d62iuk72	344	24	.	.	.
cord-001859-d62iuk72	345	1	(	(	-LRB-
cord-001859-d62iuk72	345	2	C	C	NNP
cord-001859-d62iuk72	345	3	)	)	-RRB-
cord-001859-d62iuk72	346	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	347	1	T	t	NN
cord-001859-d62iuk72	347	2	cells	cell	NNS
cord-001859-d62iuk72	347	3	were	be	VBD
cord-001859-d62iuk72	347	4	transiently	transiently	RB
cord-001859-d62iuk72	347	5	transfected	transfecte	VBN
cord-001859-d62iuk72	347	6	with	with	IN
cord-001859-d62iuk72	347	7	control	control	NN
cord-001859-d62iuk72	347	8	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	347	9	or	or	CC
cord-001859-d62iuk72	347	10	pRTA	prta	JJ
cord-001859-d62iuk72	347	11	-	-	JJ
cord-001859-d62iuk72	347	12	EGFP	EGFP	NNP
cord-001859-d62iuk72	347	13	.	.	.
cord-001859-d62iuk72	348	1	24	24	CD
cord-001859-d62iuk72	348	2	h	h	NN
cord-001859-d62iuk72	348	3	posttransfection	posttransfection	NN
cord-001859-d62iuk72	348	4	,	,	,
cord-001859-d62iuk72	348	5	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	348	6	was	be	VBD
cord-001859-d62iuk72	348	7	added	add	VBN
cord-001859-d62iuk72	348	8	and	and	CC
cord-001859-d62iuk72	348	9	incubated	incubate	VBN
cord-001859-d62iuk72	348	10	for	for	IN
cord-001859-d62iuk72	348	11	a	a	DT
cord-001859-d62iuk72	348	12	further	further	JJ
cord-001859-d62iuk72	348	13	24	24	CD
cord-001859-d62iuk72	348	14	h.	h.	NN
cord-001859-d62iuk72	349	1	Then	then	RB
cord-001859-d62iuk72	349	2	,	,	,
cord-001859-d62iuk72	349	3	immunoprecipitations	immunoprecipitation	NNS
cord-001859-d62iuk72	349	4	were	be	VBD
cord-001859-d62iuk72	349	5	carried	carry	VBN
cord-001859-d62iuk72	349	6	out	out	RP
cord-001859-d62iuk72	349	7	using	use	VBG
cord-001859-d62iuk72	349	8	a	a	DT
cord-001859-d62iuk72	349	9	GFP	GFP	NNP
cord-001859-d62iuk72	349	10	-	-	HYPH
cord-001859-d62iuk72	349	11	specific	specific	JJ
cord-001859-d62iuk72	349	12	antibody	antibody	NN
cord-001859-d62iuk72	349	13	.	.	.
cord-001859-d62iuk72	350	1	Even	even	RB
cord-001859-d62iuk72	350	2	in	in	IN
cord-001859-d62iuk72	350	3	the	the	DT
cord-001859-d62iuk72	350	4	presence	presence	NN
cord-001859-d62iuk72	350	5	of	of	IN
cord-001859-d62iuk72	350	6	55	55	CD
cord-001859-d62iuk72	350	7	μM	μm	CD
cord-001859-d62iuk72	350	8	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	350	9	the	the	DT
cord-001859-d62iuk72	350	10	interaction	interaction	NN
cord-001859-d62iuk72	350	11	between	between	IN
cord-001859-d62iuk72	350	12	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	350	13	and	and	CC
cord-001859-d62iuk72	350	14	EGFP	EGFP	NNP
cord-001859-d62iuk72	350	15	-	-	HYPH
cord-001859-d62iuk72	350	16	RTA	RTA	NNP
cord-001859-d62iuk72	350	17	was	be	VBD
cord-001859-d62iuk72	350	18	not	not	RB
cord-001859-d62iuk72	350	19	disrupted	disrupt	VBN
cord-001859-d62iuk72	350	20	.	.	.
cord-001859-d62iuk72	351	1	(	(	-LRB-
cord-001859-d62iuk72	351	2	D	d	NN
cord-001859-d62iuk72	351	3	)	)	-RRB-
cord-001859-d62iuk72	352	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	352	2	T	t	NN
cord-001859-d62iuk72	352	3	cells	cell	NNS
cord-001859-d62iuk72	352	4	were	be	VBD
cord-001859-d62iuk72	352	5	co	co	JJ
cord-001859-d62iuk72	352	6	-	-	VBN
cord-001859-d62iuk72	352	7	transfected	transfecte	VBN
cord-001859-d62iuk72	352	8	with	with	IN
cord-001859-d62iuk72	352	9	pRTA	prta	JJ
cord-001859-d62iuk72	352	10	-	-	JJ
cord-001859-d62iuk72	352	11	EGFP	egfp	NN
cord-001859-d62iuk72	352	12	along	along	IN
cord-001859-d62iuk72	352	13	with	with	IN
cord-001859-d62iuk72	352	14	the	the	DT
cord-001859-d62iuk72	352	15	Renilla	Renilla	NNP
cord-001859-d62iuk72	352	16	luciferase	luciferase	NN
cord-001859-d62iuk72	352	17	vector	vector	NN
cord-001859-d62iuk72	352	18	and	and	CC
cord-001859-d62iuk72	352	19	either	either	CC
cord-001859-d62iuk72	352	20	the	the	DT
cord-001859-d62iuk72	352	21	ORF57	ORF57	NNP
cord-001859-d62iuk72	352	22	promoter	promoter	NN
cord-001859-d62iuk72	352	23	firefly	firefly	NN
cord-001859-d62iuk72	352	24	luciferase	luciferase	NNP
cord-001859-d62iuk72	352	25	reporter	reporter	NN
cord-001859-d62iuk72	352	26	vector	vector	NN
cord-001859-d62iuk72	352	27	,	,	,
cord-001859-d62iuk72	352	28	or	or	CC
cord-001859-d62iuk72	352	29	the	the	DT
cord-001859-d62iuk72	352	30	empty	empty	JJ
cord-001859-d62iuk72	352	31	reporter	reporter	NN
cord-001859-d62iuk72	352	32	vector	vector	NN
cord-001859-d62iuk72	352	33	(	(	-LRB-
cord-001859-d62iuk72	352	34	pGL3-BASIC	pGL3-BASIC	NNP
cord-001859-d62iuk72	352	35	)	)	-RRB-
cord-001859-d62iuk72	352	36	.	.	.
cord-001859-d62iuk72	353	1	The	the	DT
cord-001859-d62iuk72	353	2	same	same	JJ
cord-001859-d62iuk72	353	3	co	co	NNS
cord-001859-d62iuk72	353	4	-	-	NNS
cord-001859-d62iuk72	353	5	transfections	transfection	NNS
cord-001859-d62iuk72	353	6	were	be	VBD
cord-001859-d62iuk72	353	7	performed	perform	VBN
cord-001859-d62iuk72	353	8	using	use	VBG
cord-001859-d62iuk72	353	9	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	353	10	as	as	IN
cord-001859-d62iuk72	353	11	a	a	DT
cord-001859-d62iuk72	353	12	negative	negative	JJ
cord-001859-d62iuk72	353	13	control	control	NN
cord-001859-d62iuk72	353	14	protein	protein	NN
cord-001859-d62iuk72	353	15	.	.	.
cord-001859-d62iuk72	354	1	24	24	CD
cord-001859-d62iuk72	355	1	h	h	LS
cord-001859-d62iuk72	355	2	post	post	NN
cord-001859-d62iuk72	355	3	-	-	NN
cord-001859-d62iuk72	355	4	transfection	transfection	JJ
cord-001859-d62iuk72	355	5	,	,	,
cord-001859-d62iuk72	355	6	cells	cell	NNS
cord-001859-d62iuk72	355	7	were	be	VBD
cord-001859-d62iuk72	355	8	exposed	expose	VBN
cord-001859-d62iuk72	355	9	for	for	IN
cord-001859-d62iuk72	355	10	2	2	CD
cord-001859-d62iuk72	355	11	h	h	NN
cord-001859-d62iuk72	355	12	to	to	IN
cord-001859-d62iuk72	355	13	VER-155008	ver-155008	NN
cord-001859-d62iuk72	355	14	and	and	CC
cord-001859-d62iuk72	355	15	luciferase	luciferase	NN
cord-001859-d62iuk72	355	16	activities	activity	NNS
cord-001859-d62iuk72	355	17	were	be	VBD
cord-001859-d62iuk72	355	18	measured	measure	VBN
cord-001859-d62iuk72	355	19	.	.	.
cord-001859-d62iuk72	356	1	Comparable	comparable	JJ
cord-001859-d62iuk72	356	2	activation	activation	NN
cord-001859-d62iuk72	356	3	of	of	IN
cord-001859-d62iuk72	356	4	the	the	DT
cord-001859-d62iuk72	356	5	RTA	RTA	NNP
cord-001859-d62iuk72	356	6	-	-	HYPH
cord-001859-d62iuk72	356	7	responsive	responsive	JJ
cord-001859-d62iuk72	356	8	ORF57	ORF57	NNP
cord-001859-d62iuk72	356	9	promoter	promoter	NN
cord-001859-d62iuk72	356	10	to	to	IN
cord-001859-d62iuk72	356	11	that	that	DT
cord-001859-d62iuk72	356	12	seen	see	VBN
cord-001859-d62iuk72	356	13	in	in	IN
cord-001859-d62iuk72	356	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	356	15	-	-	HYPH
cord-001859-d62iuk72	356	16	treated	treat	VBN
cord-001859-d62iuk72	356	17	cells	cell	NNS
cord-001859-d62iuk72	356	18	occurred	occur	VBD
cord-001859-d62iuk72	356	19	in	in	IN
cord-001859-d62iuk72	356	20	cells	cell	NNS
cord-001859-d62iuk72	356	21	treated	treat	VBN
cord-001859-d62iuk72	356	22	with	with	IN
cord-001859-d62iuk72	356	23	55	55	CD
cord-001859-d62iuk72	356	24	μM	μm	CD
cord-001859-d62iuk72	356	25	VER-155008	ver-155008	NN
cord-001859-d62iuk72	356	26	.	.	.
cord-001859-d62iuk72	357	1	The	the	DT
cord-001859-d62iuk72	357	2	results	result	NNS
cord-001859-d62iuk72	357	3	of	of	IN
cord-001859-d62iuk72	357	4	three	three	CD
cord-001859-d62iuk72	357	5	independent	independent	JJ
cord-001859-d62iuk72	357	6	transfections	transfection	NNS
cord-001859-d62iuk72	357	7	were	be	VBD
cord-001859-d62iuk72	357	8	averaged	average	VBN
cord-001859-d62iuk72	357	9	with	with	IN
cord-001859-d62iuk72	357	10	error	error	NN
cord-001859-d62iuk72	357	11	bars	bar	NNS
cord-001859-d62iuk72	357	12	as	as	IN
cord-001859-d62iuk72	357	13	standard	standard	JJ
cord-001859-d62iuk72	357	14	deviation	deviation	NN
cord-001859-d62iuk72	357	15	.	.	.
cord-001859-d62iuk72	358	1	(	(	-LRB-
cord-001859-d62iuk72	358	2	E	E	NNP
cord-001859-d62iuk72	358	3	)	)	-RRB-
cord-001859-d62iuk72	358	4	HEK-293	hek-293	JJ
cord-001859-d62iuk72	358	5	T	t	NN
cord-001859-d62iuk72	358	6	cells	cell	NNS
cord-001859-d62iuk72	358	7	were	be	VBD
cord-001859-d62iuk72	358	8	transiently	transiently	RB
cord-001859-d62iuk72	358	9	co	co	VBN
cord-001859-d62iuk72	358	10	-	-	VBN
cord-001859-d62iuk72	358	11	transfected	transfecte	VBN
cord-001859-d62iuk72	358	12	with	with	IN
cord-001859-d62iuk72	358	13	pPAN	ppan	JJ
cord-001859-d62iuk72	358	14	-	-	HYPH
cord-001859-d62iuk72	358	15	WT	WT	NNP
cord-001859-d62iuk72	358	16	and	and	CC
cord-001859-d62iuk72	358	17	either	either	DT
cord-001859-d62iuk72	358	18	pRTA	prta	JJ
cord-001859-d62iuk72	358	19	-	-	JJ
cord-001859-d62iuk72	358	20	EGFP	egfp	NN
cord-001859-d62iuk72	358	21	or	or	CC
cord-001859-d62iuk72	359	1	control	control	NNP
cord-001859-d62iuk72	359	2	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	359	3	.	.	.
cord-001859-d62iuk72	360	1	24	24	CD
cord-001859-d62iuk72	361	1	h	h	LS
cord-001859-d62iuk72	361	2	post	post	NN
cord-001859-d62iuk72	361	3	-	-	NN
cord-001859-d62iuk72	361	4	transfection	transfection	NN
cord-001859-d62iuk72	361	5	either	either	DT
cord-001859-d62iuk72	361	6	vehicle	vehicle	NN
cord-001859-d62iuk72	361	7	drug	drug	NN
cord-001859-d62iuk72	361	8	DMSO	DMSO	NNP
cord-001859-d62iuk72	361	9	(	(	-LRB-
cord-001859-d62iuk72	361	10	0.1	0.1	CD
cord-001859-d62iuk72	361	11	%	%	NN
cord-001859-d62iuk72	361	12	)	)	-RRB-
cord-001859-d62iuk72	361	13	or	or	CC
cord-001859-d62iuk72	362	1	45	45	CD
cord-001859-d62iuk72	362	2	μM	μm	CD
cord-001859-d62iuk72	362	3	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	362	4	was	be	VBD
cord-001859-d62iuk72	362	5	added	add	VBN
cord-001859-d62iuk72	362	6	and	and	CC
cord-001859-d62iuk72	362	7	incubated	incubate	VBN
cord-001859-d62iuk72	362	8	for	for	IN
cord-001859-d62iuk72	362	9	a	a	DT
cord-001859-d62iuk72	362	10	further	further	JJ
cord-001859-d62iuk72	362	11	24	24	CD
cord-001859-d62iuk72	362	12	h.	h.	NNP
cord-001859-d62iuk72	362	13	Total	Total	NNP
cord-001859-d62iuk72	362	14	RNA	RNA	NNP
cord-001859-d62iuk72	362	15	was	be	VBD
cord-001859-d62iuk72	362	16	then	then	RB
cord-001859-d62iuk72	362	17	extracted	extract	VBN
cord-001859-d62iuk72	362	18	and	and	CC
cord-001859-d62iuk72	362	19	qRT	qRT	NNP
cord-001859-d62iuk72	362	20	-	-	HYPH
cord-001859-d62iuk72	362	21	PCR	PCR	NNP
cord-001859-d62iuk72	362	22	performed	perform	VBD
cord-001859-d62iuk72	362	23	.	.	.
cord-001859-d62iuk72	363	1	RTA	RTA	NNP
cord-001859-d62iuk72	363	2	-	-	HYPH
cord-001859-d62iuk72	363	3	mediated	mediate	VBN
cord-001859-d62iuk72	363	4	promoter	promoter	NN
cord-001859-d62iuk72	363	5	transactivation	transactivation	NN
cord-001859-d62iuk72	363	6	and	and	CC
cord-001859-d62iuk72	363	7	subsequent	subsequent	JJ
cord-001859-d62iuk72	363	8	synthesis	synthesis	NN
cord-001859-d62iuk72	363	9	of	of	IN
cord-001859-d62iuk72	363	10	PAN	PAN	NNP
cord-001859-d62iuk72	363	11	RNA	RNA	NNP
cord-001859-d62iuk72	363	12	occurred	occur	VBD
cord-001859-d62iuk72	363	13	at	at	IN
cord-001859-d62iuk72	363	14	a	a	DT
cord-001859-d62iuk72	363	15	similar	similar	JJ
cord-001859-d62iuk72	363	16	rate	rate	NN
cord-001859-d62iuk72	363	17	in	in	IN
cord-001859-d62iuk72	363	18	the	the	DT
cord-001859-d62iuk72	363	19	presence	presence	NN
cord-001859-d62iuk72	363	20	of	of	IN
cord-001859-d62iuk72	363	21	VER-155008	ver-155008	NN
cord-001859-d62iuk72	363	22	or	or	CC
cord-001859-d62iuk72	363	23	control	control	NN
cord-001859-d62iuk72	363	24	DMSO	DMSO	NNP
cord-001859-d62iuk72	363	25	.	.	.
cord-001859-d62iuk72	364	1	The	the	DT
cord-001859-d62iuk72	364	2	results	result	NNS
cord-001859-d62iuk72	364	3	of	of	IN
cord-001859-d62iuk72	364	4	three	three	CD
cord-001859-d62iuk72	364	5	independent	independent	JJ
cord-001859-d62iuk72	364	6	transfections	transfection	NNS
cord-001859-d62iuk72	364	7	were	be	VBD
cord-001859-d62iuk72	364	8	averaged	average	VBN
cord-001859-d62iuk72	364	9	with	with	IN
cord-001859-d62iuk72	364	10	error	error	NN
cord-001859-d62iuk72	364	11	bars	bar	NNS
cord-001859-d62iuk72	364	12	as	as	IN
cord-001859-d62iuk72	364	13	standard	standard	JJ
cord-001859-d62iuk72	364	14	deviation	deviation	NN
cord-001859-d62iuk72	364	15	.	.	.
cord-001859-d62iuk72	365	1	(	(	-LRB-
cord-001859-d62iuk72	365	2	F	F	NNP
cord-001859-d62iuk72	365	3	)	)	-RRB-
cord-001859-d62iuk72	366	1	The	the	DT
cord-001859-d62iuk72	366	2	stability	stability	NN
cord-001859-d62iuk72	366	3	of	of	IN
cord-001859-d62iuk72	366	4	PAN	PAN	NNP
cord-001859-d62iuk72	366	5	RNA	RNA	NNP
cord-001859-d62iuk72	366	6	was	be	VBD
cord-001859-d62iuk72	366	7	determined	determine	VBN
cord-001859-d62iuk72	366	8	in	in	IN
cord-001859-d62iuk72	366	9	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	366	10	T	T	NNP
cord-001859-d62iuk72	366	11	cells	cell	NNS
cord-001859-d62iuk72	366	12	that	that	WDT
cord-001859-d62iuk72	366	13	had	have	VBD
cord-001859-d62iuk72	366	14	been	be	VBN
cord-001859-d62iuk72	366	15	co	co	VBN
cord-001859-d62iuk72	366	16	-	-	VBN
cord-001859-d62iuk72	366	17	transfected	transfecte	VBN
cord-001859-d62iuk72	366	18	with	with	IN
cord-001859-d62iuk72	366	19	pPAN	ppan	JJ
cord-001859-d62iuk72	366	20	-	-	HYPH
cord-001859-d62iuk72	366	21	WT	wt	NN
cord-001859-d62iuk72	366	22	and	and	CC
cord-001859-d62iuk72	366	23	pRTA	prta	JJ
cord-001859-d62iuk72	366	24	-	-	JJ
cord-001859-d62iuk72	366	25	EGFP	EGFP	NNP
cord-001859-d62iuk72	366	26	.	.	.
cord-001859-d62iuk72	367	1	Following	follow	VBG
cord-001859-d62iuk72	367	2	24	24	CD
cord-001859-d62iuk72	367	3	h	h	NN
cord-001859-d62iuk72	367	4	post	post	NN
cord-001859-d62iuk72	367	5	-	-	NN
cord-001859-d62iuk72	367	6	transfection	transfection	JJ
cord-001859-d62iuk72	367	7	,	,	,
cord-001859-d62iuk72	367	8	actinomycin	actinomycin	NNS
cord-001859-d62iuk72	367	9	D	D	NNP
cord-001859-d62iuk72	367	10	(	(	-LRB-
cord-001859-d62iuk72	367	11	AcD	AcD	NNP
cord-001859-d62iuk72	367	12	)	)	-RRB-
cord-001859-d62iuk72	367	13	(	(	-LRB-
cord-001859-d62iuk72	367	14	5	5	CD
cord-001859-d62iuk72	367	15	μg	μg	NN
cord-001859-d62iuk72	367	16	/	/	SYM
cord-001859-d62iuk72	367	17	ml	ml	NNP
cord-001859-d62iuk72	367	18	)	)	-RRB-
cord-001859-d62iuk72	367	19	or	or	CC
cord-001859-d62iuk72	367	20	DMSO	DMSO	NNP
cord-001859-d62iuk72	367	21	control	control	NN
cord-001859-d62iuk72	367	22	(	(	-LRB-
cord-001859-d62iuk72	367	23	0.5	0.5	CD
cord-001859-d62iuk72	367	24	%	%	NN
cord-001859-d62iuk72	367	25	)	)	-RRB-
cord-001859-d62iuk72	367	26	was	be	VBD
cord-001859-d62iuk72	367	27	added	add	VBN
cord-001859-d62iuk72	367	28	.	.	.
cord-001859-d62iuk72	368	1	Cells	cell	NNS
cord-001859-d62iuk72	368	2	were	be	VBD
cord-001859-d62iuk72	368	3	collected	collect	VBN
cord-001859-d62iuk72	368	4	over	over	IN
cord-001859-d62iuk72	368	5	the	the	DT
cord-001859-d62iuk72	368	6	time	time	NN
cord-001859-d62iuk72	368	7	points	point	NNS
cord-001859-d62iuk72	368	8	indicated	indicate	VBN
cord-001859-d62iuk72	368	9	and	and	CC
cord-001859-d62iuk72	368	10	total	total	JJ
cord-001859-d62iuk72	368	11	RNA	RNA	NNP
cord-001859-d62iuk72	368	12	was	be	VBD
cord-001859-d62iuk72	368	13	extracted	extract	VBN
cord-001859-d62iuk72	368	14	followed	follow	VBN
cord-001859-d62iuk72	368	15	by	by	IN
cord-001859-d62iuk72	368	16	qRT	qRT	NNP
cord-001859-d62iuk72	368	17	-	-	HYPH
cord-001859-d62iuk72	368	18	PCR	PCR	NNP
cord-001859-d62iuk72	368	19	.	.	.
cord-001859-d62iuk72	369	1	The	the	DT
cord-001859-d62iuk72	369	2	average	average	NN
cord-001859-d62iuk72	369	3	of	of	IN
cord-001859-d62iuk72	369	4	two	two	CD
cord-001859-d62iuk72	369	5	biological	biological	JJ
cord-001859-d62iuk72	369	6	replicates	replicate	NNS
cord-001859-d62iuk72	369	7	with	with	IN
cord-001859-d62iuk72	369	8	error	error	NN
cord-001859-d62iuk72	369	9	bar	bar	NN
cord-001859-d62iuk72	369	10	as	as	IN
cord-001859-d62iuk72	369	11	standard	standard	JJ
cord-001859-d62iuk72	369	12	deviation	deviation	NN
cord-001859-d62iuk72	369	13	is	be	VBZ
cord-001859-d62iuk72	369	14	shown	show	VBN
cord-001859-d62iuk72	369	15	.	.	.
cord-001859-d62iuk72	370	1	doi:10.1371	doi:10.1371	NNP
cord-001859-d62iuk72	370	2	/	/	SYM
cord-001859-d62iuk72	370	3	journal.ppat.1005274.g007	journal.ppat.1005274.g007	NNP
cord-001859-d62iuk72	370	4	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	370	5	Isoforms	Isoforms	NNP
cord-001859-d62iuk72	370	6	Are	be	VBP
cord-001859-d62iuk72	370	7	Essential	essential	JJ
cord-001859-d62iuk72	370	8	for	for	IN
cord-001859-d62iuk72	370	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	370	10	Lytic	Lytic	NNP
cord-001859-d62iuk72	370	11	Replication	Replication	NNP
cord-001859-d62iuk72	370	12	DMSO	dmso	NN
cord-001859-d62iuk72	370	13	-	-	HYPH
cord-001859-d62iuk72	370	14	treated	treat	VBN
cord-001859-d62iuk72	370	15	cells	cell	NNS
cord-001859-d62iuk72	371	1	predominantly	predominantly	RB
cord-001859-d62iuk72	371	2	showed	show	VBD
cord-001859-d62iuk72	371	3	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	371	4	peaks	peak	NNS
cord-001859-d62iuk72	371	5	only	only	RB
cord-001859-d62iuk72	371	6	within	within	IN
cord-001859-d62iuk72	371	7	the	the	DT
cord-001859-d62iuk72	371	8	DAPI	DAPI	NNP
cord-001859-d62iuk72	371	9	boundaries	boundary	NNS
cord-001859-d62iuk72	371	10	,	,	,
cord-001859-d62iuk72	371	11	that	that	RB
cord-001859-d62iuk72	371	12	is	is	RB
cord-001859-d62iuk72	371	13	,	,	,
cord-001859-d62iuk72	371	14	within	within	IN
cord-001859-d62iuk72	371	15	the	the	DT
cord-001859-d62iuk72	371	16	nucleus	nucleus	NN
cord-001859-d62iuk72	371	17	(	(	-LRB-
cord-001859-d62iuk72	371	18	Fig	Fig	NNP
cord-001859-d62iuk72	371	19	8A	8a	NN
cord-001859-d62iuk72	371	20	"	"	''
cord-001859-d62iuk72	371	21	)	)	-RRB-
cord-001859-d62iuk72	371	22	.	.	.
cord-001859-d62iuk72	372	1	Inhibitor	inhibitor	NN
cord-001859-d62iuk72	372	2	-	-	HYPH
cord-001859-d62iuk72	372	3	treated	treat	VBN
cord-001859-d62iuk72	372	4	cells	cell	NNS
cord-001859-d62iuk72	372	5	displayed	display	VBD
cord-001859-d62iuk72	372	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	372	7	peaks	peak	NNS
cord-001859-d62iuk72	372	8	outside	outside	IN
cord-001859-d62iuk72	372	9	the	the	DT
cord-001859-d62iuk72	372	10	DAPI	DAPI	NNP
cord-001859-d62iuk72	372	11	boundaries	boundary	NNS
cord-001859-d62iuk72	372	12	,	,	,
cord-001859-d62iuk72	372	13	that	that	RB
cord-001859-d62iuk72	372	14	is	is	RB
cord-001859-d62iuk72	372	15	,	,	,
cord-001859-d62iuk72	372	16	in	in	IN
cord-001859-d62iuk72	372	17	the	the	DT
cord-001859-d62iuk72	372	18	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	372	19	(	(	-LRB-
cord-001859-d62iuk72	372	20	Fig	fig	NN
cord-001859-d62iuk72	372	21	8B	8b	NN
cord-001859-d62iuk72	372	22	"	"	''
cord-001859-d62iuk72	372	23	asterisk	asterisk	NN
cord-001859-d62iuk72	372	24	)	)	-RRB-
cord-001859-d62iuk72	372	25	more	more	RBR
cord-001859-d62iuk72	372	26	often	often	RB
cord-001859-d62iuk72	372	27	than	than	IN
cord-001859-d62iuk72	372	28	control	control	NN
cord-001859-d62iuk72	372	29	cells	cell	NNS
cord-001859-d62iuk72	372	30	.	.	.
cord-001859-d62iuk72	373	1	A	a	DT
cord-001859-d62iuk72	373	2	significant	significant	JJ
cord-001859-d62iuk72	373	3	increase	increase	NN
cord-001859-d62iuk72	373	4	in	in	IN
cord-001859-d62iuk72	373	5	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	373	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	373	7	peaks	peak	NNS
cord-001859-d62iuk72	373	8	was	be	VBD
cord-001859-d62iuk72	373	9	seen	see	VBN
cord-001859-d62iuk72	373	10	in	in	IN
cord-001859-d62iuk72	373	11	inhibitor	inhibitor	NN
cord-001859-d62iuk72	373	12	-	-	HYPH
cord-001859-d62iuk72	373	13	treated	treat	VBN
cord-001859-d62iuk72	373	14	cells	cell	NNS
cord-001859-d62iuk72	373	15	compared	compare	VBN
cord-001859-d62iuk72	373	16	with	with	IN
cord-001859-d62iuk72	373	17	DMSO	DMSO	NNP
cord-001859-d62iuk72	373	18	control	control	NN
cord-001859-d62iuk72	373	19	cells	cell	NNS
cord-001859-d62iuk72	373	20	(	(	-LRB-
cord-001859-d62iuk72	373	21	Fig	Fig	NNP
cord-001859-d62iuk72	373	22	8C	8c	CD
cord-001859-d62iuk72	373	23	)	)	-RRB-
cord-001859-d62iuk72	373	24	.	.	.
cord-001859-d62iuk72	374	1	Fractionation	fractionation	NN
cord-001859-d62iuk72	374	2	of	of	IN
cord-001859-d62iuk72	374	3	reactivated	reactivate	VBN
cord-001859-d62iuk72	374	4	TREx	TREx	NNS
cord-001859-d62iuk72	374	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	374	6	cells	cell	NNS
cord-001859-d62iuk72	374	7	in	in	IN
cord-001859-d62iuk72	374	8	the	the	DT
cord-001859-d62iuk72	374	9	presence	presence	NN
cord-001859-d62iuk72	374	10	or	or	CC
cord-001859-d62iuk72	374	11	absence	absence	NN
cord-001859-d62iuk72	374	12	of	of	IN
cord-001859-d62iuk72	374	13	VER-155008	ver-155008	NN
cord-001859-d62iuk72	374	14	,	,	,
cord-001859-d62iuk72	374	15	also	also	RB
cord-001859-d62iuk72	374	16	pointed	point	VBD
cord-001859-d62iuk72	374	17	to	to	IN
cord-001859-d62iuk72	374	18	slightly	slightly	RB
cord-001859-d62iuk72	374	19	higher	high	JJR
cord-001859-d62iuk72	374	20	levels	level	NNS
cord-001859-d62iuk72	374	21	of	of	IN
cord-001859-d62iuk72	374	22	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	374	23	in	in	IN
cord-001859-d62iuk72	374	24	the	the	DT
cord-001859-d62iuk72	374	25	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	374	26	and	and	CC
cord-001859-d62iuk72	374	27	a	a	DT
cord-001859-d62iuk72	374	28	decrease	decrease	NN
cord-001859-d62iuk72	374	29	in	in	IN
cord-001859-d62iuk72	374	30	nuclear	nuclear	JJ
cord-001859-d62iuk72	374	31	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	374	32	in	in	IN
cord-001859-d62iuk72	374	33	inhibitor	inhibitor	NN
cord-001859-d62iuk72	374	34	-	-	HYPH
cord-001859-d62iuk72	374	35	treated	treat	VBN
cord-001859-d62iuk72	374	36	cells	cell	NNS
cord-001859-d62iuk72	374	37	compared	compare	VBN
cord-001859-d62iuk72	374	38	with	with	IN
cord-001859-d62iuk72	374	39	DMSO	DMSO	NNP
cord-001859-d62iuk72	374	40	control	control	NN
cord-001859-d62iuk72	374	41	cells	cell	NNS
cord-001859-d62iuk72	374	42	(	(	-LRB-
cord-001859-d62iuk72	374	43	Fig	Fig	NNP
cord-001859-d62iuk72	374	44	8D	8D	NNP
cord-001859-d62iuk72	374	45	)	)	-RRB-
cord-001859-d62iuk72	374	46	.	.	.
cord-001859-d62iuk72	375	1	Cells	cell	NNS
cord-001859-d62iuk72	375	2	were	be	VBD
cord-001859-d62iuk72	375	3	also	also	RB
cord-001859-d62iuk72	375	4	labelled	label	VBN
cord-001859-d62iuk72	375	5	with	with	IN
cord-001859-d62iuk72	375	6	Click	click	NN
cord-001859-d62iuk72	375	7	-	-	:
cord-001859-d62iuk72	375	8	iT	it	PRP
cord-001859-d62iuk72	376	1	EdU	EdU	NNP
cord-001859-d62iuk72	376	2	Alexa	Alexa	NNP
cord-001859-d62iuk72	376	3	Fluor	Fluor	NNP
cord-001859-d62iuk72	376	4	647	647	CD
cord-001859-d62iuk72	376	5	and	and	CC
cord-001859-d62iuk72	376	6	an	an	DT
cord-001859-d62iuk72	376	7	antibody	antibody	NN
cord-001859-d62iuk72	376	8	specific	specific	JJ
cord-001859-d62iuk72	376	9	for	for	IN
cord-001859-d62iuk72	376	10	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	376	11	(	(	-LRB-
cord-001859-d62iuk72	376	12	S7	S7	NNP
cord-001859-d62iuk72	376	13	Fig	Fig	NNP
cord-001859-d62iuk72	376	14	)	)	-RRB-
cord-001859-d62iuk72	376	15	.	.	.
cord-001859-d62iuk72	377	1	The	the	DT
cord-001859-d62iuk72	377	2	percentage	percentage	NN
cord-001859-d62iuk72	377	3	of	of	IN
cord-001859-d62iuk72	377	4	assembled	assemble	VBN
cord-001859-d62iuk72	377	5	RTCs	rtc	NNS
cord-001859-d62iuk72	377	6	in	in	IN
cord-001859-d62iuk72	377	7	DMSO	DMSO	NNP
cord-001859-d62iuk72	377	8	-	-	:
cord-001859-d62iuk72	377	9	and	and	CC
cord-001859-d62iuk72	377	10	inhibitor	inhibitor	NN
cord-001859-d62iuk72	377	11	-	-	HYPH
cord-001859-d62iuk72	377	12	treated	treat	VBN
cord-001859-d62iuk72	377	13	cells	cell	NNS
cord-001859-d62iuk72	377	14	was	be	VBD
cord-001859-d62iuk72	377	15	also	also	RB
cord-001859-d62iuk72	377	16	calculated	calculate	VBN
cord-001859-d62iuk72	377	17	.	.	.
cord-001859-d62iuk72	378	1	In	in	IN
cord-001859-d62iuk72	378	2	DMSO	DMSO	NNP
cord-001859-d62iuk72	378	3	-	-	HYPH
cord-001859-d62iuk72	378	4	treated	treat	VBN
cord-001859-d62iuk72	378	5	cells~44	cells~44	NN
cord-001859-d62iuk72	378	6	%	%	NN
cord-001859-d62iuk72	378	7	of	of	IN
cord-001859-d62iuk72	378	8	cells	cell	NNS
cord-001859-d62iuk72	378	9	presented	present	VBN
cord-001859-d62iuk72	378	10	assembled	assemble	VBN
cord-001859-d62iuk72	378	11	RTCs	rtc	NNS
cord-001859-d62iuk72	378	12	while	while	IN
cord-001859-d62iuk72	378	13	only	only	RB
cord-001859-d62iuk72	378	14	13	13	CD
cord-001859-d62iuk72	378	15	%	%	NN
cord-001859-d62iuk72	378	16	of	of	IN
cord-001859-d62iuk72	378	17	inhibitor	inhibitor	NN
cord-001859-d62iuk72	378	18	-	-	HYPH
cord-001859-d62iuk72	378	19	treated	treat	VBN
cord-001859-d62iuk72	378	20	cells	cell	NNS
cord-001859-d62iuk72	378	21	showed	show	VBD
cord-001859-d62iuk72	378	22	assembled	assemble	VBN
cord-001859-d62iuk72	378	23	RTCs	rtc	NNS
cord-001859-d62iuk72	378	24	(	(	-LRB-
cord-001859-d62iuk72	378	25	Fig	Fig	NNP
cord-001859-d62iuk72	378	26	8E	8e	CD
cord-001859-d62iuk72	378	27	)	)	-RRB-
cord-001859-d62iuk72	378	28	.	.	.
cord-001859-d62iuk72	379	1	This	this	DT
cord-001859-d62iuk72	379	2	demonstrates	demonstrate	VBZ
cord-001859-d62iuk72	379	3	that	that	IN
cord-001859-d62iuk72	379	4	chaperone	chaperone	NN
cord-001859-d62iuk72	379	5	recruitment	recruitment	NN
cord-001859-d62iuk72	379	6	to	to	IN
cord-001859-d62iuk72	379	7	the	the	DT
cord-001859-d62iuk72	379	8	nucleus	nucleus	NN
cord-001859-d62iuk72	379	9	is	be	VBZ
cord-001859-d62iuk72	379	10	essential	essential	JJ
cord-001859-d62iuk72	379	11	for	for	IN
cord-001859-d62iuk72	379	12	the	the	DT
cord-001859-d62iuk72	379	13	assembly	assembly	NN
cord-001859-d62iuk72	379	14	of	of	IN
cord-001859-d62iuk72	379	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	379	16	RTCs	rtc	NNS
cord-001859-d62iuk72	379	17	and	and	CC
cord-001859-d62iuk72	379	18	treatment	treatment	NN
cord-001859-d62iuk72	379	19	with	with	IN
cord-001859-d62iuk72	379	20	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	379	21	was	be	VBD
cord-001859-d62iuk72	379	22	sufficient	sufficient	JJ
cord-001859-d62iuk72	379	23	to	to	TO
cord-001859-d62iuk72	379	24	impair	impair	VB
cord-001859-d62iuk72	379	25	nuclear	nuclear	JJ
cord-001859-d62iuk72	379	26	chaperone	chaperone	NN
cord-001859-d62iuk72	379	27	recruitment	recruitment	NN
cord-001859-d62iuk72	379	28	and	and	CC
cord-001859-d62iuk72	379	29	KSHV	KSHV	NNP
cord-001859-d62iuk72	379	30	RTC	RTC	NNP
cord-001859-d62iuk72	379	31	formation	formation	NN
cord-001859-d62iuk72	379	32	.	.	.
cord-001859-d62iuk72	380	1	The	the	DT
cord-001859-d62iuk72	380	2	subcellular	subcellular	JJ
cord-001859-d62iuk72	380	3	localisation	localisation	NN
cord-001859-d62iuk72	380	4	of	of	IN
cord-001859-d62iuk72	380	5	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	380	6	was	be	VBD
cord-001859-d62iuk72	380	7	also	also	RB
cord-001859-d62iuk72	380	8	assessed	assess	VBN
cord-001859-d62iuk72	380	9	by	by	IN
cord-001859-d62iuk72	380	10	indirect	indirect	JJ
cord-001859-d62iuk72	380	11	immunoflourescent	immunoflourescent	NN
cord-001859-d62iuk72	380	12	labelling	labelling	NN
cord-001859-d62iuk72	380	13	in	in	IN
cord-001859-d62iuk72	380	14	TREx	TREx	NNS
cord-001859-d62iuk72	380	15	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	380	16	cells	cell	NNS
cord-001859-d62iuk72	380	17	with	with	IN
cord-001859-d62iuk72	380	18	the	the	DT
cord-001859-d62iuk72	380	19	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	380	20	antibody	antibody	NN
cord-001859-d62iuk72	380	21	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	380	22	,	,	,
cord-001859-d62iuk72	380	23	which	which	WDT
cord-001859-d62iuk72	380	24	specifically	specifically	RB
cord-001859-d62iuk72	380	25	recognises	recognise	VBZ
cord-001859-d62iuk72	380	26	unphosphorylated	unphosphorylated	NNP
cord-001859-d62iuk72	380	27	and	and	CC
cord-001859-d62iuk72	380	28	serine-5	serine-5	NNP
cord-001859-d62iuk72	380	29	phosphorylated	phosphorylated	JJ
cord-001859-d62iuk72	380	30	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	380	31	.	.	.
cord-001859-d62iuk72	381	1	In	in	IN
cord-001859-d62iuk72	381	2	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	381	3	cells	cell	NNS
cord-001859-d62iuk72	381	4	,	,	,
cord-001859-d62iuk72	381	5	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	381	6	exhibited	exhibit	VBD
cord-001859-d62iuk72	381	7	a	a	DT
cord-001859-d62iuk72	381	8	nuclear	nuclear	JJ
cord-001859-d62iuk72	381	9	localization	localization	NN
cord-001859-d62iuk72	381	10	,	,	,
cord-001859-d62iuk72	381	11	excluding	exclude	VBG
cord-001859-d62iuk72	381	12	the	the	DT
cord-001859-d62iuk72	381	13	nucleolus	nucleolus	NN
cord-001859-d62iuk72	381	14	(	(	-LRB-
cord-001859-d62iuk72	381	15	Fig	fig	NN
cord-001859-d62iuk72	381	16	9Ai	9ai	CD
cord-001859-d62iuk72	381	17	arrow	arrow	NN
cord-001859-d62iuk72	381	18	)	)	-RRB-
cord-001859-d62iuk72	381	19	irrespective	irrespective	RB
cord-001859-d62iuk72	381	20	of	of	IN
cord-001859-d62iuk72	381	21	the	the	DT
cord-001859-d62iuk72	381	22	presence	presence	NN
cord-001859-d62iuk72	381	23	of	of	IN
cord-001859-d62iuk72	381	24	DMSO	DMSO	NNP
cord-001859-d62iuk72	381	25	(	(	-LRB-
cord-001859-d62iuk72	381	26	Fig	Fig	NNP
cord-001859-d62iuk72	381	27	9Ai	9ai	CD
cord-001859-d62iuk72	381	28	)	)	-RRB-
cord-001859-d62iuk72	381	29	or	or	CC
cord-001859-d62iuk72	381	30	the	the	DT
cord-001859-d62iuk72	381	31	inhibitor	inhibitor	NN
cord-001859-d62iuk72	381	32	(	(	-LRB-
cord-001859-d62iuk72	381	33	Fig	Fig	NNP
cord-001859-d62iuk72	381	34	9Aii	9aii	CD
cord-001859-d62iuk72	381	35	)	)	-RRB-
cord-001859-d62iuk72	381	36	.	.	.
cord-001859-d62iuk72	382	1	However	however	RB
cord-001859-d62iuk72	382	2	,	,	,
cord-001859-d62iuk72	382	3	in	in	IN
cord-001859-d62iuk72	382	4	reactivated	reactivate	VBN
cord-001859-d62iuk72	382	5	and	and	CC
cord-001859-d62iuk72	382	6	DMSO	DMSO	NNP
cord-001859-d62iuk72	382	7	-	-	HYPH
cord-001859-d62iuk72	382	8	treated	treat	VBN
cord-001859-d62iuk72	382	9	cells	cell	NNS
cord-001859-d62iuk72	382	10	,	,	,
cord-001859-d62iuk72	382	11	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	382	12	was	be	VBD
cord-001859-d62iuk72	382	13	clearly	clearly	RB
cord-001859-d62iuk72	382	14	hijacked	hijack	VBN
cord-001859-d62iuk72	382	15	to	to	IN
cord-001859-d62iuk72	382	16	RTCs	RTCs	NNP
cord-001859-d62iuk72	382	17	(	(	-LRB-
cord-001859-d62iuk72	382	18	Fig	Fig	NNP
cord-001859-d62iuk72	382	19	9Bi	9bi	NN
cord-001859-d62iuk72	382	20	)	)	-RRB-
cord-001859-d62iuk72	382	21	.	.	.
cord-001859-d62iuk72	383	1	In	in	IN
cord-001859-d62iuk72	383	2	contrast	contrast	NN
cord-001859-d62iuk72	383	3	,	,	,
cord-001859-d62iuk72	383	4	in	in	IN
cord-001859-d62iuk72	383	5	reactivated	reactivate	VBN
cord-001859-d62iuk72	383	6	cells	cell	NNS
cord-001859-d62iuk72	383	7	treated	treat	VBN
cord-001859-d62iuk72	383	8	with	with	IN
cord-001859-d62iuk72	383	9	the	the	DT
cord-001859-d62iuk72	383	10	inhibitor	inhibitor	NN
cord-001859-d62iuk72	383	11	,	,	,
cord-001859-d62iuk72	383	12	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	383	13	was	be	VBD
cord-001859-d62iuk72	383	14	diffuse	diffuse	JJ
cord-001859-d62iuk72	383	15	throughout	throughout	IN
cord-001859-d62iuk72	383	16	the	the	DT
cord-001859-d62iuk72	383	17	nucleus	nucleus	NN
cord-001859-d62iuk72	383	18	,	,	,
cord-001859-d62iuk72	383	19	but	but	CC
cord-001859-d62iuk72	383	20	excluding	exclude	VBG
cord-001859-d62iuk72	383	21	the	the	DT
cord-001859-d62iuk72	383	22	nucleoli	nucleoli	NNP
cord-001859-d62iuk72	383	23	,	,	,
cord-001859-d62iuk72	383	24	and	and	CC
cord-001859-d62iuk72	383	25	formed	form	VBD
cord-001859-d62iuk72	383	26	very	very	RB
cord-001859-d62iuk72	383	27	small	small	JJ
cord-001859-d62iuk72	383	28	foci	focus	NNS
cord-001859-d62iuk72	383	29	(	(	-LRB-
cord-001859-d62iuk72	383	30	Fig	Fig	NNP
cord-001859-d62iuk72	383	31	9Bii	9bii	CD
cord-001859-d62iuk72	383	32	arrow	arrow	NN
cord-001859-d62iuk72	383	33	)	)	-RRB-
cord-001859-d62iuk72	384	1	Multiple	multiple	JJ
cord-001859-d62iuk72	384	2	KSHV	KSHV	NNP
cord-001859-d62iuk72	384	3	RTCs	rtc	NNS
cord-001859-d62iuk72	384	4	identified	identify	VBN
cord-001859-d62iuk72	384	5	by	by	IN
cord-001859-d62iuk72	384	6	RTA	RTA	NNP
cord-001859-d62iuk72	384	7	-	-	HYPH
cord-001859-d62iuk72	384	8	labelling	labelling	NN
cord-001859-d62iuk72	384	9	were	be	VBD
cord-001859-d62iuk72	384	10	formed	form	VBN
cord-001859-d62iuk72	384	11	in	in	IN
cord-001859-d62iuk72	384	12	DMSO	DMSO	NNP
cord-001859-d62iuk72	384	13	-	-	HYPH
cord-001859-d62iuk72	384	14	treated	treat	VBN
cord-001859-d62iuk72	384	15	cells	cell	NNS
cord-001859-d62iuk72	384	16	to	to	IN
cord-001859-d62iuk72	384	17	which	which	WDT
cord-001859-d62iuk72	384	18	large	large	JJ
cord-001859-d62iuk72	384	19	and	and	CC
cord-001859-d62iuk72	384	20	numerous	numerous	JJ
cord-001859-d62iuk72	384	21	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	384	22	foci	focus	NNS
cord-001859-d62iuk72	384	23	were	be	VBD
cord-001859-d62iuk72	384	24	recruited	recruit	VBN
cord-001859-d62iuk72	384	25	.	.	.
cord-001859-d62iuk72	385	1	In	in	IN
cord-001859-d62iuk72	385	2	these	these	DT
cord-001859-d62iuk72	385	3	cells	cell	NNS
cord-001859-d62iuk72	385	4	,	,	,
cord-001859-d62iuk72	385	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	385	6	was	be	VBD
cord-001859-d62iuk72	385	7	depleted	deplete	VBN
cord-001859-d62iuk72	385	8	from	from	IN
cord-001859-d62iuk72	385	9	the	the	DT
cord-001859-d62iuk72	385	10	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	385	11	.	.	.
cord-001859-d62iuk72	386	1	(	(	-LRB-
cord-001859-d62iuk72	386	2	A	a	DT
cord-001859-d62iuk72	386	3	'	'	''
cord-001859-d62iuk72	386	4	)	)	-RRB-
cord-001859-d62iuk72	387	1	Confocal	confocal	JJ
cord-001859-d62iuk72	387	2	images	image	NNS
cord-001859-d62iuk72	387	3	were	be	VBD
cord-001859-d62iuk72	387	4	subjected	subject	VBN
cord-001859-d62iuk72	387	5	to	to	IN
cord-001859-d62iuk72	387	6	profiling	profile	VBG
cord-001859-d62iuk72	387	7	analysis	analysis	NN
cord-001859-d62iuk72	387	8	using	use	VBG
cord-001859-d62iuk72	387	9	Zeiss	Zeiss	NNP
cord-001859-d62iuk72	387	10	Zen	Zen	NNP
cord-001859-d62iuk72	387	11	2011	2011	CD
cord-001859-d62iuk72	387	12	software	software	NN
cord-001859-d62iuk72	387	13	.	.	.
cord-001859-d62iuk72	388	1	Profiling	profiling	NN
cord-001859-d62iuk72	388	2	was	be	VBD
cord-001859-d62iuk72	388	3	conducted	conduct	VBN
cord-001859-d62iuk72	388	4	for	for	IN
cord-001859-d62iuk72	388	5	each	each	DT
cord-001859-d62iuk72	388	6	cell	cell	NN
cord-001859-d62iuk72	388	7	in	in	IN
cord-001859-d62iuk72	388	8	two	two	CD
cord-001859-d62iuk72	388	9	representative	representative	JJ
cord-001859-d62iuk72	388	10	confocal	confocal	JJ
cord-001859-d62iuk72	388	11	images	image	NNS
cord-001859-d62iuk72	388	12	taken	take	VBN
cord-001859-d62iuk72	388	13	with	with	IN
cord-001859-d62iuk72	388	14	a	a	DT
cord-001859-d62iuk72	388	15	40-times	40-times	CD
cord-001859-d62iuk72	388	16	objective	objective	NN
cord-001859-d62iuk72	388	17	;	;	:
cord-001859-d62iuk72	388	18	this	this	DT
cord-001859-d62iuk72	388	19	included	include	VBD
cord-001859-d62iuk72	388	20	profiling	profile	VBG
cord-001859-d62iuk72	388	21	a	a	DT
cord-001859-d62iuk72	388	22	total	total	NN
cord-001859-d62iuk72	388	23	of	of	IN
cord-001859-d62iuk72	388	24	49	49	CD
cord-001859-d62iuk72	388	25	DMSO	DMSO	NNP
cord-001859-d62iuk72	388	26	-	-	HYPH
cord-001859-d62iuk72	388	27	treated	treat	VBN
cord-001859-d62iuk72	388	28	cells	cell	NNS
cord-001859-d62iuk72	388	29	.	.	.
cord-001859-d62iuk72	389	1	A	a	DT
cord-001859-d62iuk72	389	2	representative	representative	JJ
cord-001859-d62iuk72	389	3	line	line	NN
cord-001859-d62iuk72	389	4	profile	profile	NN
cord-001859-d62iuk72	389	5	(	(	-LRB-
cord-001859-d62iuk72	389	6	yellow	yellow	JJ
cord-001859-d62iuk72	389	7	line	line	NN
cord-001859-d62iuk72	389	8	)	)	-RRB-
cord-001859-d62iuk72	389	9	and	and	CC
cord-001859-d62iuk72	389	10	accompanying	accompany	VBG
cord-001859-d62iuk72	389	11	relative	relative	JJ
cord-001859-d62iuk72	389	12	intensities	intensity	NNS
cord-001859-d62iuk72	389	13	of	of	IN
cord-001859-d62iuk72	389	14	each	each	DT
cord-001859-d62iuk72	389	15	channel	channel	NN
cord-001859-d62iuk72	389	16	at	at	IN
cord-001859-d62iuk72	389	17	every	every	DT
cord-001859-d62iuk72	389	18	pixel	pixel	NN
cord-001859-d62iuk72	389	19	along	along	IN
cord-001859-d62iuk72	389	20	the	the	DT
cord-001859-d62iuk72	389	21	line	line	NN
cord-001859-d62iuk72	389	22	is	be	VBZ
cord-001859-d62iuk72	389	23	shown	show	VBN
cord-001859-d62iuk72	389	24	for	for	IN
cord-001859-d62iuk72	389	25	a	a	DT
cord-001859-d62iuk72	389	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	389	27	-	-	HYPH
cord-001859-d62iuk72	389	28	treated	treat	VBN
cord-001859-d62iuk72	389	29	reactivated	reactivate	VBN
cord-001859-d62iuk72	389	30	cell	cell	NN
cord-001859-d62iuk72	389	31	.	.	.
cord-001859-d62iuk72	390	1	The	the	DT
cord-001859-d62iuk72	390	2	DAPI	dapi	JJ
cord-001859-d62iuk72	390	3	intensity	intensity	NN
cord-001859-d62iuk72	390	4	profile	profile	NN
cord-001859-d62iuk72	390	5	shows	show	VBZ
cord-001859-d62iuk72	390	6	values	value	NNS
cord-001859-d62iuk72	390	7	below	below	IN
cord-001859-d62iuk72	390	8	25	25	CD
cord-001859-d62iuk72	390	9	outside	outside	IN
cord-001859-d62iuk72	390	10	the	the	DT
cord-001859-d62iuk72	390	11	nucleus	nucleus	JJ
cord-001859-d62iuk72	390	12	boundary	boundary	NN
cord-001859-d62iuk72	390	13	.	.	.
cord-001859-d62iuk72	391	1	RTA	RTA	NNP
cord-001859-d62iuk72	391	2	profile	profile	NN
cord-001859-d62iuk72	391	3	shows	show	VBZ
cord-001859-d62iuk72	391	4	a	a	DT
cord-001859-d62iuk72	391	5	peak	peak	NN
cord-001859-d62iuk72	391	6	with	with	IN
cord-001859-d62iuk72	391	7	intensity	intensity	NN
cord-001859-d62iuk72	391	8	of	of	IN
cord-001859-d62iuk72	391	9	160	160	CD
cord-001859-d62iuk72	391	10	that	that	WDT
cord-001859-d62iuk72	391	11	lies	lie	VBZ
cord-001859-d62iuk72	391	12	within	within	IN
cord-001859-d62iuk72	391	13	the	the	DT
cord-001859-d62iuk72	391	14	DAPI	DAPI	NNP
cord-001859-d62iuk72	391	15	boundaries	boundary	NNS
cord-001859-d62iuk72	391	16	corresponding	correspond	VBG
cord-001859-d62iuk72	391	17	to	to	IN
cord-001859-d62iuk72	391	18	a	a	DT
cord-001859-d62iuk72	391	19	KSHV	KSHV	NNP
cord-001859-d62iuk72	391	20	replication	replication	NN
cord-001859-d62iuk72	391	21	compartment	compartment	NN
cord-001859-d62iuk72	391	22	.	.	.
cord-001859-d62iuk72	392	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	392	2	peaks	peak	NNS
cord-001859-d62iuk72	392	3	lie	lie	VBP
cord-001859-d62iuk72	392	4	within	within	IN
cord-001859-d62iuk72	392	5	the	the	DT
cord-001859-d62iuk72	392	6	DAPI	DAPI	NNP
cord-001859-d62iuk72	392	7	boundaries	boundary	NNS
cord-001859-d62iuk72	392	8	demonstrating	demonstrate	VBG
cord-001859-d62iuk72	392	9	their	-PRON-	PRP$
cord-001859-d62iuk72	392	10	nuclear	nuclear	JJ
cord-001859-d62iuk72	392	11	location	location	NN
cord-001859-d62iuk72	392	12	.	.	.
cord-001859-d62iuk72	393	1	An	an	DT
cord-001859-d62iuk72	393	2	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	393	3	intensity	intensity	NN
cord-001859-d62iuk72	393	4	peak	peak	NN
cord-001859-d62iuk72	393	5	closely	closely	RB
cord-001859-d62iuk72	393	6	resembles	resemble	VBZ
cord-001859-d62iuk72	393	7	the	the	DT
cord-001859-d62iuk72	393	8	RTA	RTA	NNP
cord-001859-d62iuk72	393	9	intensity	intensity	NN
cord-001859-d62iuk72	393	10	peak	peak	NN
cord-001859-d62iuk72	393	11	(	(	-LRB-
cord-001859-d62iuk72	393	12	arrows	arrow	NNS
cord-001859-d62iuk72	393	13	)	)	-RRB-
cord-001859-d62iuk72	393	14	,	,	,
cord-001859-d62iuk72	393	15	indicating	indicate	VBG
cord-001859-d62iuk72	393	16	co	co	NN
cord-001859-d62iuk72	393	17	-	-	NN
cord-001859-d62iuk72	393	18	localization	localization	NN
cord-001859-d62iuk72	393	19	of	of	IN
cord-001859-d62iuk72	393	20	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	393	21	with	with	IN
cord-001859-d62iuk72	393	22	RTA	RTA	NNP
cord-001859-d62iuk72	393	23	since	since	IN
cord-001859-d62iuk72	393	24	both	both	DT
cord-001859-d62iuk72	393	25	peaks	peak	NNS
cord-001859-d62iuk72	393	26	occur	occur	VBP
cord-001859-d62iuk72	393	27	at	at	IN
cord-001859-d62iuk72	393	28	the	the	DT
cord-001859-d62iuk72	393	29	same	same	JJ
cord-001859-d62iuk72	393	30	position	position	NN
cord-001859-d62iuk72	393	31	along	along	IN
cord-001859-d62iuk72	393	32	the	the	DT
cord-001859-d62iuk72	393	33	line	line	NN
cord-001859-d62iuk72	393	34	.	.	.
cord-001859-d62iuk72	394	1	(	(	-LRB-
cord-001859-d62iuk72	394	2	B	b	NN
cord-001859-d62iuk72	394	3	)	)	-RRB-
cord-001859-d62iuk72	395	1	In	in	IN
cord-001859-d62iuk72	395	2	cells	cell	NNS
cord-001859-d62iuk72	395	3	reactivated	reactivate	VBN
cord-001859-d62iuk72	395	4	and	and	CC
cord-001859-d62iuk72	395	5	treated	treat	VBN
cord-001859-d62iuk72	395	6	with	with	IN
cord-001859-d62iuk72	395	7	2	2	CD
cord-001859-d62iuk72	395	8	μM	μm	CD
cord-001859-d62iuk72	395	9	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	395	10	for	for	IN
cord-001859-d62iuk72	395	11	24	24	CD
cord-001859-d62iuk72	395	12	h	h	NNP
cord-001859-d62iuk72	395	13	,	,	,
cord-001859-d62iuk72	395	14	RTA	RTA	NNP
cord-001859-d62iuk72	395	15	was	be	VBD
cord-001859-d62iuk72	395	16	diffuse	diffuse	JJ
cord-001859-d62iuk72	395	17	in	in	IN
cord-001859-d62iuk72	395	18	the	the	DT
cord-001859-d62iuk72	395	19	nucleus	nucleus	NN
cord-001859-d62iuk72	395	20	and	and	CC
cord-001859-d62iuk72	395	21	not	not	RB
cord-001859-d62iuk72	395	22	assembled	assemble	VBN
cord-001859-d62iuk72	395	23	into	into	IN
cord-001859-d62iuk72	395	24	KSHV	KSHV	NNP
cord-001859-d62iuk72	395	25	RTCs	RTCs	NNP
cord-001859-d62iuk72	395	26	.	.	.
cord-001859-d62iuk72	396	1	In	in	IN
cord-001859-d62iuk72	396	2	addition	addition	NN
cord-001859-d62iuk72	396	3	,	,	,
cord-001859-d62iuk72	396	4	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	396	5	nuclear	nuclear	JJ
cord-001859-d62iuk72	396	6	foci	focus	NNS
cord-001859-d62iuk72	396	7	were	be	VBD
cord-001859-d62iuk72	396	8	smaller	small	JJR
cord-001859-d62iuk72	396	9	and	and	CC
cord-001859-d62iuk72	396	10	less	less	RBR
cord-001859-d62iuk72	396	11	abundant	abundant	JJ
cord-001859-d62iuk72	396	12	than	than	IN
cord-001859-d62iuk72	396	13	in	in	IN
cord-001859-d62iuk72	396	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	396	15	-	-	HYPH
cord-001859-d62iuk72	396	16	treated	treat	VBN
cord-001859-d62iuk72	396	17	cells	cell	NNS
cord-001859-d62iuk72	396	18	and	and	CC
cord-001859-d62iuk72	396	19	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	396	20	was	be	VBD
cord-001859-d62iuk72	396	21	not	not	RB
cord-001859-d62iuk72	396	22	depleted	deplete	VBN
cord-001859-d62iuk72	396	23	from	from	IN
cord-001859-d62iuk72	396	24	the	the	DT
cord-001859-d62iuk72	396	25	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	396	26	.	.	.
cord-001859-d62iuk72	397	1	(	(	-LRB-
cord-001859-d62iuk72	397	2	B	B	NNP
cord-001859-d62iuk72	397	3	'	'	''
cord-001859-d62iuk72	397	4	)	)	-RRB-
cord-001859-d62iuk72	397	5	.	.	.
cord-001859-d62iuk72	398	1	Confocal	Confocal	NNP
cord-001859-d62iuk72	398	2	profiling	profiling	NN
cord-001859-d62iuk72	398	3	was	be	VBD
cord-001859-d62iuk72	398	4	performed	perform	VBN
cord-001859-d62iuk72	398	5	for	for	IN
cord-001859-d62iuk72	398	6	each	each	DT
cord-001859-d62iuk72	398	7	cell	cell	NN
cord-001859-d62iuk72	398	8	in	in	IN
cord-001859-d62iuk72	398	9	two	two	CD
cord-001859-d62iuk72	398	10	representative	representative	JJ
cord-001859-d62iuk72	398	11	confocal	confocal	JJ
cord-001859-d62iuk72	398	12	images	image	NNS
cord-001859-d62iuk72	398	13	taken	take	VBN
cord-001859-d62iuk72	398	14	with	with	IN
cord-001859-d62iuk72	398	15	a	a	DT
cord-001859-d62iuk72	398	16	40-times	40-times	CD
cord-001859-d62iuk72	398	17	objective	objective	NN
cord-001859-d62iuk72	398	18	;	;	:
cord-001859-d62iuk72	398	19	a	a	DT
cord-001859-d62iuk72	398	20	total	total	NN
cord-001859-d62iuk72	398	21	of	of	IN
cord-001859-d62iuk72	398	22	68	68	CD
cord-001859-d62iuk72	398	23	inhibitor	inhibitor	NN
cord-001859-d62iuk72	398	24	-	-	HYPH
cord-001859-d62iuk72	398	25	treated	treat	VBN
cord-001859-d62iuk72	398	26	cells	cell	NNS
cord-001859-d62iuk72	398	27	were	be	VBD
cord-001859-d62iuk72	398	28	analysed	analyse	VBN
cord-001859-d62iuk72	398	29	.	.	.
cord-001859-d62iuk72	399	1	A	a	DT
cord-001859-d62iuk72	399	2	representative	representative	JJ
cord-001859-d62iuk72	399	3	line	line	NN
cord-001859-d62iuk72	399	4	profile	profile	NN
cord-001859-d62iuk72	399	5	(	(	-LRB-
cord-001859-d62iuk72	399	6	yellow	yellow	JJ
cord-001859-d62iuk72	399	7	line	line	NN
cord-001859-d62iuk72	399	8	)	)	-RRB-
cord-001859-d62iuk72	399	9	is	be	VBZ
cord-001859-d62iuk72	399	10	shown	show	VBN
cord-001859-d62iuk72	399	11	for	for	IN
cord-001859-d62iuk72	399	12	an	an	DT
cord-001859-d62iuk72	399	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	399	14	-	-	HYPH
cord-001859-d62iuk72	399	15	treated	treat	VBN
cord-001859-d62iuk72	399	16	cell	cell	NN
cord-001859-d62iuk72	399	17	.	.	.
cord-001859-d62iuk72	400	1	An	an	DT
cord-001859-d62iuk72	400	2	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	400	3	peak	peak	NN
cord-001859-d62iuk72	400	4	is	be	VBZ
cord-001859-d62iuk72	400	5	seen	see	VBN
cord-001859-d62iuk72	400	6	outside	outside	IN
cord-001859-d62iuk72	400	7	the	the	DT
cord-001859-d62iuk72	400	8	DAPI	DAPI	NNP
cord-001859-d62iuk72	400	9	boundaries	boundary	NNS
cord-001859-d62iuk72	400	10	corresponding	correspond	VBG
cord-001859-d62iuk72	400	11	to	to	IN
cord-001859-d62iuk72	400	12	an	an	DT
cord-001859-d62iuk72	400	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	400	14	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	400	15	peak	peak	NN
cord-001859-d62iuk72	400	16	(	(	-LRB-
cord-001859-d62iuk72	400	17	asterisk	asterisk	NN
cord-001859-d62iuk72	400	18	)	)	-RRB-
cord-001859-d62iuk72	400	19	.	.	.
cord-001859-d62iuk72	401	1	(	(	-LRB-
cord-001859-d62iuk72	401	2	C	C	NNP
cord-001859-d62iuk72	401	3	)	)	-RRB-
cord-001859-d62iuk72	401	4	Total	Total	NNP
cord-001859-d62iuk72	401	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	401	6	peaks	peak	NNS
cord-001859-d62iuk72	401	7	and	and	CC
cord-001859-d62iuk72	401	8	total	total	JJ
cord-001859-d62iuk72	401	9	nuclear	nuclear	JJ
cord-001859-d62iuk72	401	10	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	401	11	peaks	peak	NNS
cord-001859-d62iuk72	401	12	per	per	IN
cord-001859-d62iuk72	401	13	cell	cell	NN
cord-001859-d62iuk72	401	14	were	be	VBD
cord-001859-d62iuk72	401	15	combined	combine	VBN
cord-001859-d62iuk72	401	16	for	for	IN
cord-001859-d62iuk72	401	17	each	each	DT
cord-001859-d62iuk72	401	18	confocal	confocal	JJ
cord-001859-d62iuk72	401	19	image	image	NN
cord-001859-d62iuk72	401	20	and	and	CC
cord-001859-d62iuk72	401	21	experimental	experimental	JJ
cord-001859-d62iuk72	401	22	condition	condition	NN
cord-001859-d62iuk72	401	23	.	.	.
cord-001859-d62iuk72	402	1	Data	datum	NNS
cord-001859-d62iuk72	402	2	was	be	VBD
cord-001859-d62iuk72	402	3	converted	convert	VBN
cord-001859-d62iuk72	402	4	to	to	IN
cord-001859-d62iuk72	402	5	percentage	percentage	NN
cord-001859-d62iuk72	402	6	of	of	IN
cord-001859-d62iuk72	402	7	nuclear	nuclear	JJ
cord-001859-d62iuk72	402	8	and	and	CC
cord-001859-d62iuk72	402	9	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	402	10	peaks	peak	NNS
cord-001859-d62iuk72	402	11	.	.	.
cord-001859-d62iuk72	403	1	cells	cell	NNS
cord-001859-d62iuk72	403	2	exhibited	exhibit	VBD
cord-001859-d62iuk72	403	3	very	very	RB
cord-001859-d62iuk72	403	4	small	small	JJ
cord-001859-d62iuk72	403	5	RNAPII	rnapii	NN
cord-001859-d62iuk72	403	6	foci	foci	NN
cord-001859-d62iuk72	403	7	and	and	CC
cord-001859-d62iuk72	403	8	diffuse	diffuse	VB
cord-001859-d62iuk72	403	9	nuclear	nuclear	JJ
cord-001859-d62iuk72	403	10	Edu	edu	NN
cord-001859-d62iuk72	403	11	labelling	labelling	NN
cord-001859-d62iuk72	403	12	(	(	-LRB-
cord-001859-d62iuk72	403	13	S9Bii	S9Bii	NNP
cord-001859-d62iuk72	403	14	Fig	Fig	NNP
cord-001859-d62iuk72	403	15	)	)	-RRB-
cord-001859-d62iuk72	403	16	.	.	.
cord-001859-d62iuk72	404	1	To	to	TO
cord-001859-d62iuk72	404	2	confirm	confirm	VB
cord-001859-d62iuk72	404	3	that	that	DT
cord-001859-d62iuk72	404	4	inhibition	inhibition	NN
cord-001859-d62iuk72	404	5	of	of	IN
cord-001859-d62iuk72	404	6	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	404	7	isoform	isoform	NN
cord-001859-d62iuk72	404	8	function	function	NN
cord-001859-d62iuk72	404	9	was	be	VBD
cord-001859-d62iuk72	404	10	able	able	JJ
cord-001859-d62iuk72	404	11	to	to	TO
cord-001859-d62iuk72	404	12	abolish	abolish	VB
cord-001859-d62iuk72	404	13	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	404	14	recruitment	recruitment	NN
cord-001859-d62iuk72	404	15	to	to	IN
cord-001859-d62iuk72	404	16	viral	viral	JJ
cord-001859-d62iuk72	404	17	genomes	genome	NNS
cord-001859-d62iuk72	404	18	,	,	,
cord-001859-d62iuk72	404	19	we	-PRON-	PRP
cord-001859-d62iuk72	404	20	also	also	RB
cord-001859-d62iuk72	404	21	utilised	utilise	VBD
cord-001859-d62iuk72	404	22	chromatin	chromatin	NN
cord-001859-d62iuk72	404	23	immunoprecipitation	immunoprecipitation	NN
cord-001859-d62iuk72	404	24	(	(	-LRB-
cord-001859-d62iuk72	404	25	ChIP	ChIP	NNP
cord-001859-d62iuk72	404	26	)	)	-RRB-
cord-001859-d62iuk72	404	27	assays	assay	NNS
cord-001859-d62iuk72	404	28	in	in	IN
cord-001859-d62iuk72	404	29	TREx	TREx	NNS
cord-001859-d62iuk72	404	30	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	405	1	A	a	DT
cord-001859-d62iuk72	405	2	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	405	3	antibody	antibody	NN
cord-001859-d62iuk72	405	4	against	against	IN
cord-001859-d62iuk72	405	5	RTA	RTA	NNP
cord-001859-d62iuk72	405	6	and	and	CC
cord-001859-d62iuk72	405	7	a	a	DT
cord-001859-d62iuk72	405	8	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	405	9	antibody	antibody	NN
cord-001859-d62iuk72	405	10	(	(	-LRB-
cord-001859-d62iuk72	405	11	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	405	12	)	)	-RRB-
cord-001859-d62iuk72	405	13	against	against	IN
cord-001859-d62iuk72	405	14	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	405	15	were	be	VBD
cord-001859-d62iuk72	405	16	used	use	VBN
cord-001859-d62iuk72	405	17	for	for	IN
cord-001859-d62iuk72	405	18	immunoflourescence	immunoflourescence	NN
cord-001859-d62iuk72	405	19	analysis	analysis	NN
cord-001859-d62iuk72	405	20	.	.	.
cord-001859-d62iuk72	406	1	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	406	2	protein	protein	NN
cord-001859-d62iuk72	406	3	was	be	VBD
cord-001859-d62iuk72	406	4	nuclear	nuclear	JJ
cord-001859-d62iuk72	406	5	excluding	exclude	VBG
cord-001859-d62iuk72	406	6	the	the	DT
cord-001859-d62iuk72	406	7	nucleoli	nucleoli	NNP
cord-001859-d62iuk72	406	8	(	(	-LRB-
cord-001859-d62iuk72	406	9	arrows	arrow	NNS
cord-001859-d62iuk72	406	10	)	)	-RRB-
cord-001859-d62iuk72	406	11	regardless	regardless	RB
cord-001859-d62iuk72	406	12	of	of	IN
cord-001859-d62iuk72	406	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	406	14	treatment	treatment	NN
cord-001859-d62iuk72	406	15	.	.	.
cord-001859-d62iuk72	407	1	(	(	-LRB-
cord-001859-d62iuk72	407	2	B	b	NN
cord-001859-d62iuk72	407	3	)	)	-RRB-
cord-001859-d62iuk72	407	4	TREx	TREx	NNS
cord-001859-d62iuk72	407	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	407	6	cells	cell	NNS
cord-001859-d62iuk72	407	7	were	be	VBD
cord-001859-d62iuk72	407	8	reactivated	reactivate	VBN
cord-001859-d62iuk72	407	9	and	and	CC
cord-001859-d62iuk72	407	10	treated	treat	VBN
cord-001859-d62iuk72	407	11	with	with	IN
cord-001859-d62iuk72	407	12	either	either	DT
cord-001859-d62iuk72	407	13	control	control	NN
cord-001859-d62iuk72	407	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	407	15	(	(	-LRB-
cord-001859-d62iuk72	407	16	0.1	0.1	CD
cord-001859-d62iuk72	407	17	%	%	NN
cord-001859-d62iuk72	407	18	)	)	-RRB-
cord-001859-d62iuk72	407	19	or	or	CC
cord-001859-d62iuk72	408	1	2	2	LS
cord-001859-d62iuk72	408	2	μM	μm	CD
cord-001859-d62iuk72	408	3	VER-155008	ver-155008	NN
cord-001859-d62iuk72	408	4	for	for	IN
cord-001859-d62iuk72	408	5	24	24	CD
cord-001859-d62iuk72	408	6	h.	h.	NN
cord-001859-d62iuk72	409	1	In	in	IN
cord-001859-d62iuk72	409	2	DMSO	DMSO	NNP
cord-001859-d62iuk72	409	3	-	-	HYPH
cord-001859-d62iuk72	409	4	treated	treat	VBN
cord-001859-d62iuk72	409	5	cells	cell	NNS
cord-001859-d62iuk72	409	6	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	409	7	and	and	CC
cord-001859-d62iuk72	409	8	RTA	RTA	NNP
cord-001859-d62iuk72	409	9	were	be	VBD
cord-001859-d62iuk72	409	10	recruited	recruit	VBN
cord-001859-d62iuk72	409	11	to	to	IN
cord-001859-d62iuk72	409	12	viral	viral	JJ
cord-001859-d62iuk72	409	13	RTCs	rtc	NNS
cord-001859-d62iuk72	409	14	(	(	-LRB-
cord-001859-d62iuk72	409	15	i	i	PRP
cord-001859-d62iuk72	409	16	arrow	arrow	NN
cord-001859-d62iuk72	409	17	)	)	-RRB-
cord-001859-d62iuk72	409	18	while	while	IN
cord-001859-d62iuk72	409	19	in	in	IN
cord-001859-d62iuk72	409	20	inhibitor	inhibitor	NN
cord-001859-d62iuk72	409	21	-	-	HYPH
cord-001859-d62iuk72	409	22	treated	treat	VBN
cord-001859-d62iuk72	409	23	cells	cell	NNS
cord-001859-d62iuk72	409	24	RTA	RTA	NNP
cord-001859-d62iuk72	409	25	was	be	VBD
cord-001859-d62iuk72	409	26	diffuse	diffuse	JJ
cord-001859-d62iuk72	409	27	in	in	IN
cord-001859-d62iuk72	409	28	the	the	DT
cord-001859-d62iuk72	409	29	nucleus	nucleus	NN
cord-001859-d62iuk72	409	30	and	and	CC
cord-001859-d62iuk72	409	31	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	409	32	formed	form	VBD
cord-001859-d62iuk72	409	33	numerous	numerous	JJ
cord-001859-d62iuk72	409	34	small	small	JJ
cord-001859-d62iuk72	409	35	foci	foci	NN
cord-001859-d62iuk72	409	36	that	that	WDT
cord-001859-d62iuk72	409	37	excluded	exclude	VBD
cord-001859-d62iuk72	409	38	the	the	DT
cord-001859-d62iuk72	409	39	nucleoli	nucleoli	NNP
cord-001859-d62iuk72	409	40	and	and	CC
cord-001859-d62iuk72	409	41	resembled	resemble	VBD
cord-001859-d62iuk72	409	42	prereplicative	prereplicative	JJ
cord-001859-d62iuk72	409	43	sites	site	NNS
cord-001859-d62iuk72	409	44	(	(	-LRB-
cord-001859-d62iuk72	409	45	ii	ii	NNP
cord-001859-d62iuk72	409	46	arrow	arrow	NNP
cord-001859-d62iuk72	409	47	)	)	-RRB-
cord-001859-d62iuk72	409	48	.	.	.
cord-001859-d62iuk72	410	1	(	(	-LRB-
cord-001859-d62iuk72	410	2	C	C	NNP
cord-001859-d62iuk72	410	3	)	)	-RRB-
cord-001859-d62iuk72	410	4	TREx	TREx	NNS
cord-001859-d62iuk72	410	5	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	410	6	cells	cell	NNS
cord-001859-d62iuk72	410	7	were	be	VBD
cord-001859-d62iuk72	410	8	either	either	RB
cord-001859-d62iuk72	410	9	reactivated	reactivate	VBN
cord-001859-d62iuk72	410	10	(	(	-LRB-
cord-001859-d62iuk72	410	11	R	r	NN
cord-001859-d62iuk72	410	12	)	)	-RRB-
cord-001859-d62iuk72	410	13	in	in	IN
cord-001859-d62iuk72	410	14	the	the	DT
cord-001859-d62iuk72	410	15	presence	presence	NN
cord-001859-d62iuk72	410	16	of	of	IN
cord-001859-d62iuk72	410	17	DMSO	DMSO	NNP
cord-001859-d62iuk72	410	18	(	(	-LRB-
cord-001859-d62iuk72	410	19	0.1	0.1	CD
cord-001859-d62iuk72	410	20	%	%	NN
cord-001859-d62iuk72	410	21	)	)	-RRB-
cord-001859-d62iuk72	410	22	or	or	CC
cord-001859-d62iuk72	411	1	2	2	LS
cord-001859-d62iuk72	411	2	μM	μm	CD
cord-001859-d62iuk72	411	3	VER-155008	ver-155008	NN
cord-001859-d62iuk72	411	4	for	for	IN
cord-001859-d62iuk72	411	5	24	24	CD
cord-001859-d62iuk72	411	6	h.	h.	NN
cord-001859-d62iuk72	411	7	Unreactivated	Unreactivated	NNP
cord-001859-d62iuk72	411	8	(	(	-LRB-
cord-001859-d62iuk72	411	9	U	U	NNP
cord-001859-d62iuk72	411	10	)	)	-RRB-
cord-001859-d62iuk72	411	11	cells	cell	NNS
cord-001859-d62iuk72	411	12	treated	treat	VBN
cord-001859-d62iuk72	411	13	with	with	IN
cord-001859-d62iuk72	411	14	DMSO	DMSO	NNP
cord-001859-d62iuk72	411	15	(	(	-LRB-
cord-001859-d62iuk72	411	16	0.1	0.1	CD
cord-001859-d62iuk72	411	17	%	%	NN
cord-001859-d62iuk72	411	18	)	)	-RRB-
cord-001859-d62iuk72	411	19	were	be	VBD
cord-001859-d62iuk72	411	20	used	use	VBN
cord-001859-d62iuk72	411	21	to	to	TO
cord-001859-d62iuk72	411	22	assess	assess	VB
cord-001859-d62iuk72	411	23	levels	level	NNS
cord-001859-d62iuk72	411	24	of	of	IN
cord-001859-d62iuk72	411	25	lytic	lytic	JJ
cord-001859-d62iuk72	411	26	reactivation	reactivation	NN
cord-001859-d62iuk72	411	27	.	.	.
cord-001859-d62iuk72	412	1	ChIP	chip	NN
cord-001859-d62iuk72	412	2	assays	assay	NNS
cord-001859-d62iuk72	412	3	were	be	VBD
cord-001859-d62iuk72	412	4	carried	carry	VBN
cord-001859-d62iuk72	412	5	out	out	RP
cord-001859-d62iuk72	412	6	with	with	IN
cord-001859-d62iuk72	412	7	either	either	DT
cord-001859-d62iuk72	412	8	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	412	9	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	412	10	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	412	11	antibody	antibody	NN
cord-001859-d62iuk72	412	12	or	or	CC
cord-001859-d62iuk72	412	13	mouse	mouse	NN
cord-001859-d62iuk72	412	14	control	control	NNP
cord-001859-d62iuk72	412	15	antibody	antibody	NNP
cord-001859-d62iuk72	412	16	(	(	-LRB-
cord-001859-d62iuk72	412	17	IgG	IgG	NNP
cord-001859-d62iuk72	412	18	)	)	-RRB-
cord-001859-d62iuk72	412	19	.	.	.
cord-001859-d62iuk72	413	1	In	in	IN
cord-001859-d62iuk72	413	2	the	the	DT
cord-001859-d62iuk72	413	3	presence	presence	NN
cord-001859-d62iuk72	413	4	of	of	IN
cord-001859-d62iuk72	413	5	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	413	6	,	,	,
cord-001859-d62iuk72	413	7	significantly	significantly	RB
cord-001859-d62iuk72	413	8	reduced	reduce	VBN
cord-001859-d62iuk72	413	9	amounts	amount	NNS
cord-001859-d62iuk72	413	10	of	of	IN
cord-001859-d62iuk72	413	11	RNAPII	rnapii	NN
cord-001859-d62iuk72	413	12	bound	bind	VBN
cord-001859-d62iuk72	413	13	to	to	IN
cord-001859-d62iuk72	413	14	viral	viral	JJ
cord-001859-d62iuk72	413	15	promoters	promoter	NNS
cord-001859-d62iuk72	413	16	were	be	VBD
cord-001859-d62iuk72	413	17	detected	detect	VBN
cord-001859-d62iuk72	413	18	.	.	.
cord-001859-d62iuk72	414	1	The	the	DT
cord-001859-d62iuk72	414	2	average	average	NN
cord-001859-d62iuk72	414	3	of	of	IN
cord-001859-d62iuk72	414	4	three	three	CD
cord-001859-d62iuk72	414	5	independent	independent	JJ
cord-001859-d62iuk72	414	6	experiments	experiment	NNS
cord-001859-d62iuk72	414	7	is	be	VBZ
cord-001859-d62iuk72	414	8	shown	show	VBN
cord-001859-d62iuk72	414	9	with	with	IN
cord-001859-d62iuk72	414	10	error	error	NN
cord-001859-d62iuk72	414	11	bars	bar	NNS
cord-001859-d62iuk72	414	12	as	as	IN
cord-001859-d62iuk72	414	13	standard	standard	JJ
cord-001859-d62iuk72	414	14	deviation	deviation	NN
cord-001859-d62iuk72	414	15	.	.	.
cord-001859-d62iuk72	415	1	cells	cell	NNS
cord-001859-d62iuk72	415	2	that	that	WDT
cord-001859-d62iuk72	415	3	were	be	VBD
cord-001859-d62iuk72	415	4	either	either	RB
cord-001859-d62iuk72	415	5	reactivated	reactivate	VBN
cord-001859-d62iuk72	415	6	for	for	IN
cord-001859-d62iuk72	415	7	24	24	CD
cord-001859-d62iuk72	415	8	h	h	NN
cord-001859-d62iuk72	415	9	in	in	IN
cord-001859-d62iuk72	415	10	the	the	DT
cord-001859-d62iuk72	415	11	presence	presence	NN
cord-001859-d62iuk72	415	12	of	of	IN
cord-001859-d62iuk72	415	13	DMSO	DMSO	NNP
cord-001859-d62iuk72	415	14	or	or	CC
cord-001859-d62iuk72	416	1	2	2	LS
cord-001859-d62iuk72	416	2	μM	μm	CD
cord-001859-d62iuk72	417	1	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	418	1	(	(	-LRB-
cord-001859-d62iuk72	418	2	Fig	Fig	NNP
cord-001859-d62iuk72	418	3	 	 	_SP
cord-001859-d62iuk72	418	4	9C	9c	CD
cord-001859-d62iuk72	418	5	)	)	-RRB-
cord-001859-d62iuk72	418	6	.	.	.
cord-001859-d62iuk72	419	1	In	in	IN
cord-001859-d62iuk72	419	2	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	419	3	control	control	NN
cord-001859-d62iuk72	419	4	cells	cell	NNS
cord-001859-d62iuk72	419	5	,	,	,
cord-001859-d62iuk72	419	6	there	there	EX
cord-001859-d62iuk72	419	7	was	be	VBD
cord-001859-d62iuk72	419	8	a	a	DT
cord-001859-d62iuk72	419	9	clear	clear	JJ
cord-001859-d62iuk72	419	10	enrichment	enrichment	NN
cord-001859-d62iuk72	419	11	of	of	IN
cord-001859-d62iuk72	419	12	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	419	13	at	at	IN
cord-001859-d62iuk72	419	14	the	the	DT
cord-001859-d62iuk72	419	15	promoter	promoter	NN
cord-001859-d62iuk72	419	16	of	of	IN
cord-001859-d62iuk72	419	17	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	419	18	gene	gene	NN
cord-001859-d62iuk72	419	19	,	,	,
cord-001859-d62iuk72	419	20	while	while	IN
cord-001859-d62iuk72	419	21	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	419	22	occupancy	occupancy	NN
cord-001859-d62iuk72	419	23	at	at	IN
cord-001859-d62iuk72	419	24	viral	viral	JJ
cord-001859-d62iuk72	419	25	promoters	promoter	NNS
cord-001859-d62iuk72	419	26	was	be	VBD
cord-001859-d62iuk72	419	27	minimal	minimal	JJ
cord-001859-d62iuk72	419	28	.	.	.
cord-001859-d62iuk72	420	1	However	however	RB
cord-001859-d62iuk72	420	2	,	,	,
cord-001859-d62iuk72	420	3	KSHV	KSHV	NNP
cord-001859-d62iuk72	420	4	reactivation	reactivation	NN
cord-001859-d62iuk72	420	5	in	in	IN
cord-001859-d62iuk72	420	6	DMSO	DMSO	NNP
cord-001859-d62iuk72	420	7	-	-	HYPH
cord-001859-d62iuk72	420	8	treated	treat	VBN
cord-001859-d62iuk72	420	9	cells	cell	NNS
cord-001859-d62iuk72	420	10	led	lead	VBD
cord-001859-d62iuk72	420	11	to	to	IN
cord-001859-d62iuk72	420	12	a	a	DT
cord-001859-d62iuk72	420	13	drastic	drastic	JJ
cord-001859-d62iuk72	420	14	reduction	reduction	NN
cord-001859-d62iuk72	420	15	of	of	IN
cord-001859-d62iuk72	420	16	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	420	17	at	at	IN
cord-001859-d62iuk72	420	18	the	the	DT
cord-001859-d62iuk72	420	19	promoter	promoter	NN
cord-001859-d62iuk72	420	20	of	of	IN
cord-001859-d62iuk72	420	21	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	420	22	and	and	CC
cord-001859-d62iuk72	420	23	a	a	DT
cord-001859-d62iuk72	420	24	significant	significant	JJ
cord-001859-d62iuk72	420	25	increase	increase	NN
cord-001859-d62iuk72	420	26	of	of	IN
cord-001859-d62iuk72	420	27	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	420	28	at	at	IN
cord-001859-d62iuk72	420	29	the	the	DT
cord-001859-d62iuk72	420	30	viral	viral	JJ
cord-001859-d62iuk72	420	31	promoters	promoter	NNS
cord-001859-d62iuk72	420	32	in	in	IN
cord-001859-d62iuk72	420	33	agreement	agreement	NN
cord-001859-d62iuk72	420	34	with	with	IN
cord-001859-d62iuk72	420	35	the	the	DT
cord-001859-d62iuk72	420	36	previous	previous	JJ
cord-001859-d62iuk72	420	37	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	420	38	results	result	NNS
cord-001859-d62iuk72	420	39	,	,	,
cord-001859-d62iuk72	420	40	showing	show	VBG
cord-001859-d62iuk72	420	41	RNAPII	rnapii	NN
cord-001859-d62iuk72	420	42	recruitment	recruitment	NN
cord-001859-d62iuk72	420	43	to	to	IN
cord-001859-d62iuk72	420	44	RTCs	rtc	NNS
cord-001859-d62iuk72	420	45	(	(	-LRB-
cord-001859-d62iuk72	420	46	Fig	Fig	NNP
cord-001859-d62iuk72	420	47	9Bi	9bi	NN
cord-001859-d62iuk72	420	48	)	)	-RRB-
cord-001859-d62iuk72	420	49	.	.	.
cord-001859-d62iuk72	421	1	Conversely	conversely	RB
cord-001859-d62iuk72	421	2	,	,	,
cord-001859-d62iuk72	421	3	upon	upon	IN
cord-001859-d62iuk72	421	4	treatment	treatment	NN
cord-001859-d62iuk72	421	5	of	of	IN
cord-001859-d62iuk72	421	6	the	the	DT
cord-001859-d62iuk72	421	7	HSP70	HSP70	NNP
cord-001859-d62iuk72	421	8	inhibitor	inhibitor	NN
cord-001859-d62iuk72	421	9	,	,	,
cord-001859-d62iuk72	421	10	the	the	DT
cord-001859-d62iuk72	421	11	amount	amount	NN
cord-001859-d62iuk72	421	12	of	of	IN
cord-001859-d62iuk72	421	13	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	421	14	bound	bind	VBN
cord-001859-d62iuk72	421	15	at	at	IN
cord-001859-d62iuk72	421	16	the	the	DT
cord-001859-d62iuk72	421	17	promoters	promoter	NNS
cord-001859-d62iuk72	421	18	of	of	IN
cord-001859-d62iuk72	421	19	ori	ori	NNP
cord-001859-d62iuk72	421	20	-	-	HYPH
cord-001859-d62iuk72	421	21	Lyt	Lyt	NNP
cord-001859-d62iuk72	421	22	,	,	,
cord-001859-d62iuk72	421	23	K12	K12	NNP
cord-001859-d62iuk72	421	24	and	and	CC
cord-001859-d62iuk72	421	25	ORF59	ORF59	NNP
cord-001859-d62iuk72	421	26	was	be	VBD
cord-001859-d62iuk72	421	27	decreased	decrease	VBN
cord-001859-d62iuk72	421	28	by~65%,~70	by~65%,~70	NNP
cord-001859-d62iuk72	421	29	%	%	NN
cord-001859-d62iuk72	421	30	and~50	and~50	CD
cord-001859-d62iuk72	421	31	%	%	NN
cord-001859-d62iuk72	421	32	respectively	respectively	RB
cord-001859-d62iuk72	421	33	compared	compare	VBN
cord-001859-d62iuk72	421	34	with	with	IN
cord-001859-d62iuk72	421	35	DMSO	DMSO	NNP
cord-001859-d62iuk72	421	36	-	-	HYPH
cord-001859-d62iuk72	421	37	treated	treat	VBN
cord-001859-d62iuk72	421	38	reactivated	reactivate	VBN
cord-001859-d62iuk72	421	39	cells	cell	NNS
cord-001859-d62iuk72	421	40	.	.	.
cord-001859-d62iuk72	422	1	Importantly	importantly	RB
cord-001859-d62iuk72	422	2	,	,	,
cord-001859-d62iuk72	422	3	these	these	DT
cord-001859-d62iuk72	422	4	results	result	NNS
cord-001859-d62iuk72	422	5	indicate	indicate	VBP
cord-001859-d62iuk72	422	6	for	for	IN
cord-001859-d62iuk72	422	7	the	the	DT
cord-001859-d62iuk72	422	8	first	first	JJ
cord-001859-d62iuk72	422	9	time	time	NN
cord-001859-d62iuk72	422	10	that	that	DT
cord-001859-d62iuk72	422	11	inhibition	inhibition	NN
cord-001859-d62iuk72	422	12	of	of	IN
cord-001859-d62iuk72	422	13	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	422	14	isoforms	isoform	NNS
cord-001859-d62iuk72	422	15	leads	lead	VBZ
cord-001859-d62iuk72	422	16	to	to	IN
cord-001859-d62iuk72	422	17	a	a	DT
cord-001859-d62iuk72	422	18	severe	severe	JJ
cord-001859-d62iuk72	422	19	impairment	impairment	NN
cord-001859-d62iuk72	422	20	in	in	IN
cord-001859-d62iuk72	422	21	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	422	22	recruitment	recruitment	NN
cord-001859-d62iuk72	422	23	at	at	IN
cord-001859-d62iuk72	422	24	multiple	multiple	JJ
cord-001859-d62iuk72	422	25	viral	viral	JJ
cord-001859-d62iuk72	422	26	promoters	promoter	NNS
cord-001859-d62iuk72	422	27	including	include	VBG
cord-001859-d62iuk72	422	28	that	that	DT
cord-001859-d62iuk72	422	29	of	of	IN
cord-001859-d62iuk72	422	30	ori	ori	NNP
cord-001859-d62iuk72	422	31	-	-	HYPH
cord-001859-d62iuk72	422	32	Lyt	Lyt	NNP
cord-001859-d62iuk72	422	33	.	.	.
cord-001859-d62iuk72	423	1	To	to	TO
cord-001859-d62iuk72	423	2	further	further	RB
cord-001859-d62iuk72	423	3	confirm	confirm	VB
cord-001859-d62iuk72	423	4	the	the	DT
cord-001859-d62iuk72	423	5	essential	essential	JJ
cord-001859-d62iuk72	423	6	role	role	NN
cord-001859-d62iuk72	423	7	of	of	IN
cord-001859-d62iuk72	423	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	424	1	and	and	CC
cord-001859-d62iuk72	424	2	iHsp70	ihsp70	TO
cord-001859-d62iuk72	424	3	in	in	IN
cord-001859-d62iuk72	424	4	the	the	DT
cord-001859-d62iuk72	424	5	formation	formation	NN
cord-001859-d62iuk72	424	6	of	of	IN
cord-001859-d62iuk72	424	7	KSHV	KSHV	NNP
cord-001859-d62iuk72	424	8	RTCs	RTCs	NNP
cord-001859-d62iuk72	424	9	,	,	,
cord-001859-d62iuk72	424	10	specific	specific	JJ
cord-001859-d62iuk72	424	11	individual	individual	JJ
cord-001859-d62iuk72	424	12	siRNA	sirna	NN
cord-001859-d62iuk72	424	13	-	-	HYPH
cord-001859-d62iuk72	424	14	mediated	mediate	VBN
cord-001859-d62iuk72	424	15	depletion	depletion	NN
cord-001859-d62iuk72	424	16	of	of	IN
cord-001859-d62iuk72	424	17	both	both	DT
cord-001859-d62iuk72	424	18	isoforms	isoform	NNS
cord-001859-d62iuk72	425	1	was	be	VBD
cord-001859-d62iuk72	425	2	performed	perform	VBN
cord-001859-d62iuk72	425	3	in	in	IN
cord-001859-d62iuk72	425	4	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	425	5	T	t	NN
cord-001859-d62iuk72	425	6	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	425	7	cells	cell	NNS
cord-001859-d62iuk72	425	8	.	.	.
cord-001859-d62iuk72	426	1	Following	follow	VBG
cord-001859-d62iuk72	426	2	four	four	CD
cord-001859-d62iuk72	426	3	days	day	NNS
cord-001859-d62iuk72	426	4	post	post	NN
cord-001859-d62iuk72	426	5	-	-	JJ
cord-001859-d62iuk72	426	6	siRNA	sirna	JJ
cord-001859-d62iuk72	426	7	transfection	transfection	NN
cord-001859-d62iuk72	426	8	,	,	,
cord-001859-d62iuk72	426	9	cells	cell	NNS
cord-001859-d62iuk72	426	10	were	be	VBD
cord-001859-d62iuk72	426	11	reactivated	reactivate	VBN
cord-001859-d62iuk72	426	12	for	for	IN
cord-001859-d62iuk72	426	13	24	24	CD
cord-001859-d62iuk72	426	14	h	h	NNP
cord-001859-d62iuk72	426	15	and	and	CC
cord-001859-d62iuk72	426	16	RNA	RNA	NNP
cord-001859-d62iuk72	426	17	and	and	CC
cord-001859-d62iuk72	426	18	protein	protein	NN
cord-001859-d62iuk72	426	19	were	be	VBD
cord-001859-d62iuk72	426	20	extracted	extract	VBN
cord-001859-d62iuk72	426	21	from	from	IN
cord-001859-d62iuk72	426	22	the	the	DT
cord-001859-d62iuk72	426	23	same	same	JJ
cord-001859-d62iuk72	426	24	sample	sample	NN
cord-001859-d62iuk72	426	25	.	.	.
cord-001859-d62iuk72	427	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	427	2	depletion	depletion	NN
cord-001859-d62iuk72	427	3	was	be	VBD
cord-001859-d62iuk72	427	4	evaluated	evaluate	VBN
cord-001859-d62iuk72	427	5	by	by	IN
cord-001859-d62iuk72	427	6	Western	western	JJ
cord-001859-d62iuk72	427	7	blotting	blotting	NN
cord-001859-d62iuk72	427	8	and	and	CC
cord-001859-d62iuk72	427	9	by	by	IN
cord-001859-d62iuk72	427	10	qRT	qRT	NNP
cord-001859-d62iuk72	427	11	-	-	HYPH
cord-001859-d62iuk72	427	12	PCR	PCR	NNP
cord-001859-d62iuk72	427	13	,	,	,
cord-001859-d62iuk72	427	14	the	the	DT
cord-001859-d62iuk72	427	15	latter	latter	JJ
cord-001859-d62iuk72	427	16	showing~85	showing~85	NN
cord-001859-d62iuk72	427	17	%	%	NN
cord-001859-d62iuk72	428	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	428	2	mRNA	mrna	NN
cord-001859-d62iuk72	428	3	knockdown	knockdown	NN
cord-001859-d62iuk72	428	4	(	(	-LRB-
cord-001859-d62iuk72	428	5	Fig	Fig	NNP
cord-001859-d62iuk72	428	6	 	 	_SP
cord-001859-d62iuk72	428	7	10A	10a	NN
cord-001859-d62iuk72	428	8	)	)	-RRB-
cord-001859-d62iuk72	428	9	.	.	.
cord-001859-d62iuk72	429	1	In	in	IN
cord-001859-d62iuk72	429	2	contrast	contrast	NN
cord-001859-d62iuk72	429	3	,	,	,
cord-001859-d62iuk72	429	4	iHsp70	ihsp70	IN
cord-001859-d62iuk72	429	5	mRNA	mRNA	NNP
cord-001859-d62iuk72	429	6	levels	level	NNS
cord-001859-d62iuk72	429	7	were	be	VBD
cord-001859-d62iuk72	429	8	not	not	RB
cord-001859-d62iuk72	429	9	affected	affect	VBN
cord-001859-d62iuk72	429	10	confirming	confirm	VBG
cord-001859-d62iuk72	429	11	specificity	specificity	NN
cord-001859-d62iuk72	429	12	of	of	IN
cord-001859-d62iuk72	429	13	the	the	DT
cord-001859-d62iuk72	429	14	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	429	15	siRNA	siRNA	NNP
cord-001859-d62iuk72	429	16	.	.	.
cord-001859-d62iuk72	430	1	Despite	despite	IN
cord-001859-d62iuk72	430	2	a	a	DT
cord-001859-d62iuk72	430	3	successful	successful	JJ
cord-001859-d62iuk72	430	4	knockdown	knockdown	NN
cord-001859-d62iuk72	430	5	at	at	IN
cord-001859-d62iuk72	430	6	the	the	DT
cord-001859-d62iuk72	430	7	mRNA	mRNA	NNP
cord-001859-d62iuk72	430	8	level	level	NN
cord-001859-d62iuk72	430	9	,	,	,
cord-001859-d62iuk72	430	10	significant	significant	JJ
cord-001859-d62iuk72	430	11	amounts	amount	NNS
cord-001859-d62iuk72	430	12	of	of	IN
cord-001859-d62iuk72	430	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	430	14	protein	protein	NN
cord-001859-d62iuk72	430	15	remained	remain	VBD
cord-001859-d62iuk72	430	16	in	in	IN
cord-001859-d62iuk72	430	17	Hsc70-depleted	hsc70-deplete	VBN
cord-001859-d62iuk72	430	18	cells	cell	NNS
cord-001859-d62iuk72	430	19	(	(	-LRB-
cord-001859-d62iuk72	430	20	Fig	Fig	NNP
cord-001859-d62iuk72	430	21	10B	10b	NN
cord-001859-d62iuk72	430	22	)	)	-RRB-
cord-001859-d62iuk72	430	23	.	.	.
cord-001859-d62iuk72	431	1	However	however	RB
cord-001859-d62iuk72	431	2	,	,	,
cord-001859-d62iuk72	431	3	even	even	RB
cord-001859-d62iuk72	431	4	with	with	IN
cord-001859-d62iuk72	431	5	this	this	DT
cord-001859-d62iuk72	431	6	modest	modest	JJ
cord-001859-d62iuk72	431	7	amount	amount	NN
cord-001859-d62iuk72	431	8	of	of	IN
cord-001859-d62iuk72	431	9	depletion	depletion	NN
cord-001859-d62iuk72	431	10	at	at	IN
cord-001859-d62iuk72	431	11	the	the	DT
cord-001859-d62iuk72	431	12	protein	protein	NN
cord-001859-d62iuk72	431	13	level	level	NN
cord-001859-d62iuk72	431	14	,	,	,
cord-001859-d62iuk72	431	15	all	all	DT
cord-001859-d62iuk72	431	16	viral	viral	JJ
cord-001859-d62iuk72	431	17	transcripts	transcript	NNS
cord-001859-d62iuk72	431	18	(	(	-LRB-
cord-001859-d62iuk72	431	19	with	with	IN
cord-001859-d62iuk72	431	20	the	the	DT
cord-001859-d62iuk72	431	21	exception	exception	NN
cord-001859-d62iuk72	431	22	of	of	IN
cord-001859-d62iuk72	431	23	PAN	PAN	NNP
cord-001859-d62iuk72	431	24	)	)	-RRB-
cord-001859-d62iuk72	431	25	displayed	display	VBD
cord-001859-d62iuk72	431	26	a	a	DT
cord-001859-d62iuk72	431	27	significant	significant	JJ
cord-001859-d62iuk72	431	28	reduction	reduction	NN
cord-001859-d62iuk72	431	29	in	in	IN
cord-001859-d62iuk72	431	30	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	431	31	siRNA	siRNA	NNP
cord-001859-d62iuk72	431	32	-	-	HYPH
cord-001859-d62iuk72	431	33	treated	treat	VBN
cord-001859-d62iuk72	431	34	samples	sample	NNS
cord-001859-d62iuk72	431	35	compared	compare	VBN
cord-001859-d62iuk72	431	36	with	with	IN
cord-001859-d62iuk72	431	37	the	the	DT
cord-001859-d62iuk72	431	38	scramble	scramble	NN
cord-001859-d62iuk72	431	39	siRNAtreated	sirnatreated	JJ
cord-001859-d62iuk72	431	40	cells	cell	NNS
cord-001859-d62iuk72	431	41	as	as	IN
cord-001859-d62iuk72	431	42	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	431	43	by	by	IN
cord-001859-d62iuk72	431	44	qRT	qRT	NNP
cord-001859-d62iuk72	431	45	-	-	HYPH
cord-001859-d62iuk72	431	46	PCR	PCR	NNP
cord-001859-d62iuk72	431	47	analysis	analysis	NN
cord-001859-d62iuk72	431	48	(	(	-LRB-
cord-001859-d62iuk72	431	49	Fig	Fig	NNP
cord-001859-d62iuk72	431	50	10C	10c	CD
cord-001859-d62iuk72	431	51	)	)	-RRB-
cord-001859-d62iuk72	431	52	.	.	.
cord-001859-d62iuk72	432	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	432	2	,	,	,
cord-001859-d62iuk72	432	3	ORF74	ORF74	NNP
cord-001859-d62iuk72	432	4	and	and	CC
cord-001859-d62iuk72	432	5	gL	gl	NN
cord-001859-d62iuk72	433	1	mRNA	mrna	NN
cord-001859-d62iuk72	433	2	levels	level	NNS
cord-001859-d62iuk72	433	3	were	be	VBD
cord-001859-d62iuk72	433	4	decreased	decrease	VBN
cord-001859-d62iuk72	433	5	by~40	by~40	NNP
cord-001859-d62iuk72	433	6	%	%	NN
cord-001859-d62iuk72	433	7	following	follow	VBG
cord-001859-d62iuk72	433	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	433	9	knockdown	knockdown	NN
cord-001859-d62iuk72	433	10	.	.	.
cord-001859-d62iuk72	434	1	Ori	Ori	NNP
cord-001859-d62iuk72	434	2	-	-	HYPH
cord-001859-d62iuk72	434	3	Lyt	Lyt	NNP
cord-001859-d62iuk72	434	4	and	and	CC
cord-001859-d62iuk72	434	5	RTA	RTA	NNP
cord-001859-d62iuk72	434	6	transcripts	transcript	NNS
cord-001859-d62iuk72	434	7	were	be	VBD
cord-001859-d62iuk72	434	8	reduced	reduce	VBN
cord-001859-d62iuk72	434	9	by~30	by~30	NNP
cord-001859-d62iuk72	434	10	%	%	NN
cord-001859-d62iuk72	434	11	and	and	CC
cord-001859-d62iuk72	434	12	gB	gB	NNP
cord-001859-d62iuk72	434	13	levels	level	NNS
cord-001859-d62iuk72	434	14	by~20	by~20	NNP
cord-001859-d62iuk72	434	15	%	%	NN
cord-001859-d62iuk72	434	16	.	.	.
cord-001859-d62iuk72	435	1	This	this	DT
cord-001859-d62iuk72	435	2	suggests	suggest	VBZ
cord-001859-d62iuk72	435	3	that	that	IN
cord-001859-d62iuk72	435	4	depletion	depletion	NN
cord-001859-d62iuk72	435	5	of	of	IN
cord-001859-d62iuk72	435	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	435	7	impaired	impair	VBD
cord-001859-d62iuk72	435	8	the	the	DT
cord-001859-d62iuk72	435	9	expression	expression	NN
cord-001859-d62iuk72	435	10	of	of	IN
cord-001859-d62iuk72	435	11	viral	viral	JJ
cord-001859-d62iuk72	435	12	genes	gene	NNS
cord-001859-d62iuk72	435	13	from	from	IN
cord-001859-d62iuk72	435	14	various	various	JJ
cord-001859-d62iuk72	435	15	temporal	temporal	JJ
cord-001859-d62iuk72	435	16	classes	class	NNS
cord-001859-d62iuk72	435	17	and	and	CC
cord-001859-d62iuk72	435	18	thus	thus	RB
cord-001859-d62iuk72	435	19	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	435	20	may	may	MD
cord-001859-d62iuk72	435	21	be	be	VB
cord-001859-d62iuk72	435	22	necessary	necessary	JJ
cord-001859-d62iuk72	435	23	for	for	IN
cord-001859-d62iuk72	435	24	KSHV	KSHV	NNP
cord-001859-d62iuk72	435	25	RTC	RTC	NNP
cord-001859-d62iuk72	435	26	formation	formation	NN
cord-001859-d62iuk72	435	27	.	.	.
cord-001859-d62iuk72	436	1	Viral	viral	JJ
cord-001859-d62iuk72	436	2	DNA	dna	NN
cord-001859-d62iuk72	436	3	replication	replication	NN
cord-001859-d62iuk72	436	4	was	be	VBD
cord-001859-d62iuk72	436	5	also	also	RB
cord-001859-d62iuk72	436	6	assessed	assess	VBN
cord-001859-d62iuk72	436	7	following	follow	VBG
cord-001859-d62iuk72	436	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	436	9	knockdown	knockdown	NN
cord-001859-d62iuk72	436	10	.	.	.
cord-001859-d62iuk72	437	1	For	for	IN
cord-001859-d62iuk72	437	2	this	this	DT
cord-001859-d62iuk72	437	3	,	,	,
cord-001859-d62iuk72	437	4	after	after	IN
cord-001859-d62iuk72	437	5	four	four	CD
cord-001859-d62iuk72	437	6	days	day	NNS
cord-001859-d62iuk72	437	7	post	post	NN
cord-001859-d62iuk72	437	8	-	-	JJ
cord-001859-d62iuk72	437	9	siRNA	sirna	JJ
cord-001859-d62iuk72	437	10	transfection	transfection	NN
cord-001859-d62iuk72	437	11	,	,	,
cord-001859-d62iuk72	437	12	cells	cell	NNS
cord-001859-d62iuk72	437	13	were	be	VBD
cord-001859-d62iuk72	437	14	reactivated	reactivate	VBN
cord-001859-d62iuk72	437	15	for	for	IN
cord-001859-d62iuk72	438	1	a	a	DT
cord-001859-d62iuk72	438	2	further	further	JJ
cord-001859-d62iuk72	438	3	72	72	CD
cord-001859-d62iuk72	438	4	h.	h.	NN
cord-001859-d62iuk72	438	5	There	there	EX
cord-001859-d62iuk72	438	6	were	be	VBD
cord-001859-d62iuk72	438	7	no	no	DT
cord-001859-d62iuk72	438	8	significant	significant	JJ
cord-001859-d62iuk72	438	9	differences	difference	NNS
cord-001859-d62iuk72	438	10	between	between	IN
cord-001859-d62iuk72	438	11	scramble	scramble	NN
cord-001859-d62iuk72	438	12	and	and	CC
cord-001859-d62iuk72	438	13	depleted	depleted	JJ
cord-001859-d62iuk72	438	14	cells	cell	NNS
cord-001859-d62iuk72	438	15	(	(	-LRB-
cord-001859-d62iuk72	438	16	Fig	Fig	NNP
cord-001859-d62iuk72	438	17	10D	10d	CD
cord-001859-d62iuk72	438	18	)	)	-RRB-
cord-001859-d62iuk72	438	19	.	.	.
cord-001859-d62iuk72	439	1	The	the	DT
cord-001859-d62iuk72	439	2	production	production	NN
cord-001859-d62iuk72	439	3	of	of	IN
cord-001859-d62iuk72	439	4	infectious	infectious	JJ
cord-001859-d62iuk72	439	5	KSHV	KSHV	NNP
cord-001859-d62iuk72	439	6	virions	virion	NNS
cord-001859-d62iuk72	439	7	was	be	VBD
cord-001859-d62iuk72	439	8	also	also	RB
cord-001859-d62iuk72	439	9	evaluated	evaluate	VBN
cord-001859-d62iuk72	439	10	after	after	IN
cord-001859-d62iuk72	439	11	72	72	CD
cord-001859-d62iuk72	439	12	h	h	NN
cord-001859-d62iuk72	439	13	reactivation	reactivation	NN
cord-001859-d62iuk72	439	14	.	.	.
cord-001859-d62iuk72	440	1	Again	again	RB
cord-001859-d62iuk72	440	2	,	,	,
cord-001859-d62iuk72	440	3	no	no	DT
cord-001859-d62iuk72	440	4	significant	significant	JJ
cord-001859-d62iuk72	440	5	differences	difference	NNS
cord-001859-d62iuk72	440	6	were	be	VBD
cord-001859-d62iuk72	440	7	seen	see	VBN
cord-001859-d62iuk72	440	8	between	between	IN
cord-001859-d62iuk72	440	9	scramble	scramble	NN
cord-001859-d62iuk72	440	10	and	and	CC
cord-001859-d62iuk72	440	11	depleted	depleted	JJ
cord-001859-d62iuk72	440	12	cells	cell	NNS
cord-001859-d62iuk72	440	13	(	(	-LRB-
cord-001859-d62iuk72	440	14	Fig	Fig	NNP
cord-001859-d62iuk72	440	15	10E	10e	CD
cord-001859-d62iuk72	440	16	)	)	-RRB-
cord-001859-d62iuk72	440	17	;	;	:
cord-001859-d62iuk72	440	18	however	however	RB
cord-001859-d62iuk72	440	19	this	this	DT
cord-001859-d62iuk72	440	20	result	result	NN
cord-001859-d62iuk72	440	21	is	be	VBZ
cord-001859-d62iuk72	440	22	not	not	RB
cord-001859-d62iuk72	440	23	surprising	surprising	JJ
cord-001859-d62iuk72	440	24	due	due	IN
cord-001859-d62iuk72	440	25	to	to	IN
cord-001859-d62iuk72	440	26	incomplete	incomplete	JJ
cord-001859-d62iuk72	440	27	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	440	28	depletion	depletion	NN
cord-001859-d62iuk72	440	29	even	even	RB
cord-001859-d62iuk72	440	30	after	after	IN
cord-001859-d62iuk72	440	31	seven	seven	CD
cord-001859-d62iuk72	440	32	days	day	NNS
cord-001859-d62iuk72	440	33	post	post	NN
cord-001859-d62iuk72	440	34	-	-	JJ
cord-001859-d62iuk72	440	35	transfection	transfection	JJ
cord-001859-d62iuk72	440	36	(	(	-LRB-
cord-001859-d62iuk72	440	37	Fig	Fig	NNP
cord-001859-d62iuk72	440	38	10F	10f	NN
cord-001859-d62iuk72	440	39	)	)	-RRB-
cord-001859-d62iuk72	440	40	.	.	.
cord-001859-d62iuk72	441	1	This	this	DT
cord-001859-d62iuk72	441	2	highlights	highlight	VBZ
cord-001859-d62iuk72	441	3	the	the	DT
cord-001859-d62iuk72	441	4	remarkable	remarkable	JJ
cord-001859-d62iuk72	441	5	stability	stability	NN
cord-001859-d62iuk72	441	6	of	of	IN
cord-001859-d62iuk72	441	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	441	8	protein	protein	NN
cord-001859-d62iuk72	441	9	in	in	IN
cord-001859-d62iuk72	441	10	this	this	DT
cord-001859-d62iuk72	441	11	cell	cell	NN
cord-001859-d62iuk72	441	12	line	line	NN
cord-001859-d62iuk72	441	13	and	and	CC
cord-001859-d62iuk72	441	14	it	-PRON-	PRP
cord-001859-d62iuk72	441	15	suggests	suggest	VBZ
cord-001859-d62iuk72	441	16	that	that	IN
cord-001859-d62iuk72	441	17	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	441	18	depletion	depletion	NN
cord-001859-d62iuk72	441	19	was	be	VBD
cord-001859-d62iuk72	441	20	enough	enough	JJ
cord-001859-d62iuk72	441	21	to	to	TO
cord-001859-d62iuk72	441	22	cause	cause	VB
cord-001859-d62iuk72	441	23	a	a	DT
cord-001859-d62iuk72	441	24	reduction	reduction	NN
cord-001859-d62iuk72	441	25	in	in	IN
cord-001859-d62iuk72	441	26	viral	viral	JJ
cord-001859-d62iuk72	441	27	transcripts	transcript	NNS
cord-001859-d62iuk72	441	28	but	but	CC
cord-001859-d62iuk72	441	29	not	not	RB
cord-001859-d62iuk72	441	30	enough	enough	JJ
cord-001859-d62iuk72	441	31	to	to	TO
cord-001859-d62iuk72	441	32	cause	cause	VB
cord-001859-d62iuk72	441	33	a	a	DT
cord-001859-d62iuk72	441	34	reduction	reduction	NN
cord-001859-d62iuk72	441	35	in	in	IN
cord-001859-d62iuk72	441	36	the	the	DT
cord-001859-d62iuk72	441	37	amount	amount	NN
cord-001859-d62iuk72	441	38	of	of	IN
cord-001859-d62iuk72	441	39	viral	viral	JJ
cord-001859-d62iuk72	441	40	proteins	protein	NNS
cord-001859-d62iuk72	441	41	,	,	,
cord-001859-d62iuk72	441	42	thus	thus	RB
cord-001859-d62iuk72	441	43	KSHV	KSHV	NNP
cord-001859-d62iuk72	441	44	lytic	lytic	JJ
cord-001859-d62iuk72	441	45	replication	replication	NN
cord-001859-d62iuk72	441	46	remained	remain	VBD
cord-001859-d62iuk72	441	47	unaffected	unaffected	JJ
cord-001859-d62iuk72	441	48	.	.	.
cord-001859-d62iuk72	442	1	It	-PRON-	PRP
cord-001859-d62iuk72	442	2	is	be	VBZ
cord-001859-d62iuk72	442	3	also	also	RB
cord-001859-d62iuk72	442	4	possible	possible	JJ
cord-001859-d62iuk72	442	5	that	that	IN
cord-001859-d62iuk72	442	6	iHsp70	iHsp70	``
cord-001859-d62iuk72	442	7	was	be	VBD
cord-001859-d62iuk72	442	8	able	able	JJ
cord-001859-d62iuk72	442	9	to	to	TO
cord-001859-d62iuk72	442	10	functionally	functionally	RB
cord-001859-d62iuk72	442	11	compensate	compensate	VB
cord-001859-d62iuk72	442	12	for	for	IN
cord-001859-d62iuk72	442	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	442	14	.	.	.
cord-001859-d62iuk72	443	1	Next	next	RB
cord-001859-d62iuk72	443	2	,	,	,
cord-001859-d62iuk72	443	3	specific	specific	JJ
cord-001859-d62iuk72	443	4	depletion	depletion	NN
cord-001859-d62iuk72	443	5	of	of	IN
cord-001859-d62iuk72	443	6	iHsp70	ihsp70	NN
cord-001859-d62iuk72	443	7	was	be	VBD
cord-001859-d62iuk72	443	8	performed	perform	VBN
cord-001859-d62iuk72	443	9	in	in	IN
cord-001859-d62iuk72	443	10	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	443	11	T	t	NN
cord-001859-d62iuk72	443	12	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	443	13	cells	cell	NNS
cord-001859-d62iuk72	443	14	.	.	.
cord-001859-d62iuk72	444	1	iHsp70	ihsp70	IN
cord-001859-d62iuk72	444	2	depletion	depletion	NN
cord-001859-d62iuk72	444	3	at	at	IN
cord-001859-d62iuk72	444	4	the	the	DT
cord-001859-d62iuk72	444	5	mRNA	mRNA	NNP
cord-001859-d62iuk72	444	6	level	level	NN
cord-001859-d62iuk72	444	7	reached~75	reached~75	NNP
cord-001859-d62iuk72	444	8	%	%	NN
cord-001859-d62iuk72	444	9	knockdown	knockdown	NN
cord-001859-d62iuk72	444	10	(	(	-LRB-
cord-001859-d62iuk72	444	11	Fig	Fig	NNP
cord-001859-d62iuk72	444	12	11A	11a	NN
cord-001859-d62iuk72	444	13	)	)	-RRB-
cord-001859-d62iuk72	444	14	which	which	WDT
cord-001859-d62iuk72	444	15	correlated	correlate	VBD
cord-001859-d62iuk72	444	16	with	with	IN
cord-001859-d62iuk72	444	17	efficient	efficient	JJ
cord-001859-d62iuk72	444	18	depletion	depletion	NN
cord-001859-d62iuk72	444	19	at	at	IN
cord-001859-d62iuk72	444	20	the	the	DT
cord-001859-d62iuk72	444	21	protein	protein	NN
cord-001859-d62iuk72	444	22	level	level	NN
cord-001859-d62iuk72	444	23	(	(	-LRB-
cord-001859-d62iuk72	444	24	Fig	Fig	NNP
cord-001859-d62iuk72	444	25	11B	11b	CD
cord-001859-d62iuk72	444	26	)	)	-RRB-
cord-001859-d62iuk72	444	27	.	.	.
cord-001859-d62iuk72	445	1	However	however	RB
cord-001859-d62iuk72	445	2	,	,	,
cord-001859-d62iuk72	445	3	in	in	IN
cord-001859-d62iuk72	445	4	iHsp70-depleted	iHsp70-depleted	NNP
cord-001859-d62iuk72	445	5	cells	cell	NNS
cord-001859-d62iuk72	445	6	,	,	,
cord-001859-d62iuk72	445	7	the	the	DT
cord-001859-d62iuk72	445	8	majority	majority	NN
cord-001859-d62iuk72	445	9	of	of	IN
cord-001859-d62iuk72	445	10	viral	viral	JJ
cord-001859-d62iuk72	445	11	gene	gene	NN
cord-001859-d62iuk72	445	12	expression	expression	NN
cord-001859-d62iuk72	445	13	was	be	VBD
cord-001859-d62iuk72	445	14	unaffected	unaffected	JJ
cord-001859-d62iuk72	445	15	,	,	,
cord-001859-d62iuk72	445	16	apart	apart	RB
cord-001859-d62iuk72	445	17	from	from	IN
cord-001859-d62iuk72	445	18	gL	gL	NNP
cord-001859-d62iuk72	445	19	and	and	CC
cord-001859-d62iuk72	445	20	PAN	PAN	NNP
cord-001859-d62iuk72	445	21	transcripts	transcript	NNS
cord-001859-d62iuk72	445	22	which	which	WDT
cord-001859-d62iuk72	445	23	were	be	VBD
cord-001859-d62iuk72	445	24	decreased	decrease	VBN
cord-001859-d62iuk72	445	25	bỹ	bỹ	IN
cord-001859-d62iuk72	445	26	40	40	CD
cord-001859-d62iuk72	445	27	%	%	NN
cord-001859-d62iuk72	445	28	and~20	and~20	CD
cord-001859-d62iuk72	445	29	%	%	NN
cord-001859-d62iuk72	445	30	respectively	respectively	RB
cord-001859-d62iuk72	445	31	(	(	-LRB-
cord-001859-d62iuk72	445	32	Fig	fig	NN
cord-001859-d62iuk72	445	33	11C	11c	CD
cord-001859-d62iuk72	445	34	)	)	-RRB-
cord-001859-d62iuk72	445	35	.	.	.
cord-001859-d62iuk72	446	1	Importantly	importantly	RB
cord-001859-d62iuk72	446	2	,	,	,
cord-001859-d62iuk72	446	3	taken	take	VBN
cord-001859-d62iuk72	446	4	together	together	RB
cord-001859-d62iuk72	446	5	these	these	DT
cord-001859-d62iuk72	446	6	results	result	NNS
cord-001859-d62iuk72	446	7	indicate	indicate	VBP
cord-001859-d62iuk72	446	8	that	that	IN
cord-001859-d62iuk72	446	9	partial	partial	JJ
cord-001859-d62iuk72	446	10	depletion	depletion	NN
cord-001859-d62iuk72	446	11	of	of	IN
cord-001859-d62iuk72	446	12	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	446	13	at	at	IN
cord-001859-d62iuk72	446	14	the	the	DT
cord-001859-d62iuk72	446	15	protein	protein	NN
cord-001859-d62iuk72	446	16	level	level	NN
cord-001859-d62iuk72	446	17	is	be	VBZ
cord-001859-d62iuk72	446	18	sufficient	sufficient	JJ
cord-001859-d62iuk72	446	19	to	to	TO
cord-001859-d62iuk72	446	20	cause	cause	VB
cord-001859-d62iuk72	446	21	a	a	DT
cord-001859-d62iuk72	446	22	reduction	reduction	NN
cord-001859-d62iuk72	446	23	in	in	IN
cord-001859-d62iuk72	446	24	viral	viral	JJ
cord-001859-d62iuk72	446	25	transcription	transcription	NN
cord-001859-d62iuk72	446	26	,	,	,
cord-001859-d62iuk72	446	27	suggesting	suggest	VBG
cord-001859-d62iuk72	446	28	an	an	DT
cord-001859-d62iuk72	446	29	essential	essential	JJ
cord-001859-d62iuk72	446	30	role	role	NN
cord-001859-d62iuk72	446	31	of	of	IN
cord-001859-d62iuk72	446	32	this	this	DT
cord-001859-d62iuk72	446	33	chaperone	chaperone	NN
cord-001859-d62iuk72	446	34	in	in	IN
cord-001859-d62iuk72	446	35	the	the	DT
cord-001859-d62iuk72	446	36	formation	formation	NN
cord-001859-d62iuk72	446	37	of	of	IN
cord-001859-d62iuk72	446	38	KSHV	KSHV	NNP
cord-001859-d62iuk72	446	39	RTCs	rtc	NNS
cord-001859-d62iuk72	446	40	,	,	,
cord-001859-d62iuk72	446	41	whereas	whereas	IN
cord-001859-d62iuk72	446	42	iHsp70	iHsp70	``
cord-001859-d62iuk72	446	43	may	may	MD
cord-001859-d62iuk72	446	44	have	have	VB
cord-001859-d62iuk72	446	45	a	a	DT
cord-001859-d62iuk72	446	46	more	more	RBR
cord-001859-d62iuk72	446	47	subtle	subtle	JJ
cord-001859-d62iuk72	446	48	effect	effect	NN
cord-001859-d62iuk72	446	49	on	on	IN
cord-001859-d62iuk72	446	50	viral	viral	JJ
cord-001859-d62iuk72	446	51	gene	gene	NN
cord-001859-d62iuk72	446	52	expression	expression	NN
cord-001859-d62iuk72	446	53	.	.	.
cord-001859-d62iuk72	447	1	To	to	TO
cord-001859-d62iuk72	447	2	further	further	RB
cord-001859-d62iuk72	447	3	support	support	VB
cord-001859-d62iuk72	447	4	the	the	DT
cord-001859-d62iuk72	447	5	essential	essential	JJ
cord-001859-d62iuk72	447	6	role	role	NN
cord-001859-d62iuk72	447	7	of	of	IN
cord-001859-d62iuk72	447	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	447	9	during	during	IN
cord-001859-d62iuk72	447	10	KSHV	KSHV	NNP
cord-001859-d62iuk72	447	11	RTC	RTC	NNP
cord-001859-d62iuk72	447	12	formation	formation	NN
cord-001859-d62iuk72	447	13	,	,	,
cord-001859-d62iuk72	447	14	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	447	15	was	be	VBD
cord-001859-d62iuk72	447	16	specifically	specifically	RB
cord-001859-d62iuk72	447	17	silenced	silence	VBN
cord-001859-d62iuk72	447	18	in	in	IN
cord-001859-d62iuk72	447	19	TREx	TREx	NNS
cord-001859-d62iuk72	447	20	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	447	21	cells	cell	NNS
cord-001859-d62iuk72	447	22	.	.	.
cord-001859-d62iuk72	448	1	For	for	IN
cord-001859-d62iuk72	448	2	this	this	DT
cord-001859-d62iuk72	448	3	,	,	,
cord-001859-d62iuk72	448	4	nucleofection	nucleofection	NN
cord-001859-d62iuk72	448	5	was	be	VBD
cord-001859-d62iuk72	448	6	carried	carry	VBN
cord-001859-d62iuk72	448	7	out	out	RP
cord-001859-d62iuk72	448	8	.	.	.
cord-001859-d62iuk72	449	1	Transfection	transfection	NN
cord-001859-d62iuk72	449	2	efficiency	efficiency	NN
cord-001859-d62iuk72	449	3	was	be	VBD
cord-001859-d62iuk72	449	4	monitored	monitor	VBN
cord-001859-d62iuk72	449	5	co	co	JJ
cord-001859-d62iuk72	449	6	-	-	JJ
cord-001859-d62iuk72	449	7	transfecting	transfecte	VBG
cord-001859-d62iuk72	449	8	the	the	DT
cord-001859-d62iuk72	449	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	449	10	siRNA	siRNA	NNP
cord-001859-d62iuk72	449	11	together	together	RB
cord-001859-d62iuk72	449	12	with	with	IN
cord-001859-d62iuk72	449	13	pmaxGFP	pmaxGFP	NNP
cord-001859-d62iuk72	449	14	,	,	,
cord-001859-d62iuk72	449	15	which	which	WDT
cord-001859-d62iuk72	449	16	encodes	encode	VBZ
cord-001859-d62iuk72	449	17	maxGFP	maxGFP	NNP
cord-001859-d62iuk72	449	18	,	,	,
cord-001859-d62iuk72	449	19	a	a	DT
cord-001859-d62iuk72	449	20	green	green	JJ
cord-001859-d62iuk72	449	21	fluorescent	fluorescent	NN
cord-001859-d62iuk72	449	22	protein	protein	NN
cord-001859-d62iuk72	449	23	from	from	IN
cord-001859-d62iuk72	449	24	the	the	DT
cord-001859-d62iuk72	449	25	copepod	copepod	NN
cord-001859-d62iuk72	449	26	Pontellina	Pontellina	NNP
cord-001859-d62iuk72	449	27	p.	p.	NN
cord-001859-d62iuk72	450	1	(	(	-LRB-
cord-001859-d62iuk72	450	2	Fig	Fig	NNP
cord-001859-d62iuk72	450	3	12A	12a	CD
cord-001859-d62iuk72	450	4	)	)	-RRB-
cord-001859-d62iuk72	450	5	.	.	.
cord-001859-d62iuk72	451	1	Note	note	VB
cord-001859-d62iuk72	451	2	that	that	IN
cord-001859-d62iuk72	451	3	higher	high	JJR
cord-001859-d62iuk72	451	4	transfection	transfection	NN
cord-001859-d62iuk72	451	5	efficiency	efficiency	NN
cord-001859-d62iuk72	451	6	is	be	VBZ
cord-001859-d62iuk72	451	7	expected	expect	VBN
cord-001859-d62iuk72	451	8	for	for	IN
cord-001859-d62iuk72	451	9	the	the	DT
cord-001859-d62iuk72	451	10	siRNA	siRNA	NNP
cord-001859-d62iuk72	451	11	due	due	IN
cord-001859-d62iuk72	451	12	to	to	IN
cord-001859-d62iuk72	451	13	the	the	DT
cord-001859-d62iuk72	451	14	smaller	small	JJR
cord-001859-d62iuk72	451	15	size	size	NN
cord-001859-d62iuk72	451	16	of	of	IN
cord-001859-d62iuk72	451	17	this	this	DT
cord-001859-d62iuk72	451	18	compared	compare	VBN
cord-001859-d62iuk72	451	19	with	with	IN
cord-001859-d62iuk72	451	20	the	the	DT
cord-001859-d62iuk72	451	21	plasmid	plasmid	NN
cord-001859-d62iuk72	451	22	DNA	dna	NN
cord-001859-d62iuk72	451	23	.	.	.
cord-001859-d62iuk72	452	1	After	after	IN
cord-001859-d62iuk72	452	2	four	four	CD
cord-001859-d62iuk72	452	3	days	day	NNS
cord-001859-d62iuk72	452	4	post	post	NN
cord-001859-d62iuk72	452	5	-	-	NN
cord-001859-d62iuk72	452	6	nucleofection	nucleofection	JJ
cord-001859-d62iuk72	452	7	,	,	,
cord-001859-d62iuk72	452	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	452	9	mRNA	mRNA	NNP
cord-001859-d62iuk72	452	10	levels	level	NNS
cord-001859-d62iuk72	452	11	showed~90	showed~90	NNP
cord-001859-d62iuk72	452	12	%	%	NN
cord-001859-d62iuk72	452	13	knockdown	knockdown	NN
cord-001859-d62iuk72	452	14	(	(	-LRB-
cord-001859-d62iuk72	452	15	Fig	Fig	NNP
cord-001859-d62iuk72	452	16	12B	12b	CD
cord-001859-d62iuk72	452	17	)	)	-RRB-
cord-001859-d62iuk72	452	18	with	with	IN
cord-001859-d62iuk72	452	19	a	a	DT
cord-001859-d62iuk72	452	20	minor	minor	JJ
cord-001859-d62iuk72	452	21	depletion	depletion	NN
cord-001859-d62iuk72	452	22	at	at	IN
cord-001859-d62iuk72	452	23	the	the	DT
cord-001859-d62iuk72	452	24	protein	protein	NN
cord-001859-d62iuk72	452	25	level	level	NN
cord-001859-d62iuk72	452	26	(	(	-LRB-
cord-001859-d62iuk72	452	27	Fig	Fig	NNP
cord-001859-d62iuk72	452	28	12C	12C	NNP
cord-001859-d62iuk72	452	29	)	)	-RRB-
cord-001859-d62iuk72	452	30	.	.	.
cord-001859-d62iuk72	453	1	Due	due	IN
cord-001859-d62iuk72	453	2	to	to	IN
cord-001859-d62iuk72	453	3	the	the	DT
cord-001859-d62iuk72	453	4	stability	stability	NN
cord-001859-d62iuk72	453	5	of	of	IN
cord-001859-d62iuk72	453	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	453	7	protein	protein	NN
cord-001859-d62iuk72	453	8	,	,	,
cord-001859-d62iuk72	453	9	cells	cell	NNS
cord-001859-d62iuk72	453	10	were	be	VBD
cord-001859-d62iuk72	453	11	incubated	incubate	VBN
cord-001859-d62iuk72	453	12	for	for	IN
cord-001859-d62iuk72	453	13	six	six	CD
cord-001859-d62iuk72	453	14	days	day	NNS
cord-001859-d62iuk72	453	15	post	post	NN
cord-001859-d62iuk72	453	16	-	-	NN
cord-001859-d62iuk72	453	17	nucleofection	nucleofection	NN
cord-001859-d62iuk72	453	18	followed	follow	VBN
cord-001859-d62iuk72	453	19	by	by	IN
cord-001859-d62iuk72	453	20	a	a	DT
cord-001859-d62iuk72	453	21	further	further	JJ
cord-001859-d62iuk72	453	22	24	24	CD
cord-001859-d62iuk72	453	23	h	h	NN
cord-001859-d62iuk72	453	24	reactivation	reactivation	NN
cord-001859-d62iuk72	453	25	and	and	CC
cord-001859-d62iuk72	453	26	immunofluorescence	immunofluorescence	NN
cord-001859-d62iuk72	453	27	for	for	IN
cord-001859-d62iuk72	453	28	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	453	29	and	and	CC
cord-001859-d62iuk72	453	30	RTA	RTA	NNP
cord-001859-d62iuk72	453	31	was	be	VBD
cord-001859-d62iuk72	453	32	carried	carry	VBN
cord-001859-d62iuk72	453	33	out	out	RP
cord-001859-d62iuk72	453	34	.	.	.
cord-001859-d62iuk72	454	1	RTC	RTC	NNP
cord-001859-d62iuk72	454	2	formation	formation	NN
cord-001859-d62iuk72	454	3	dramatically	dramatically	RB
cord-001859-d62iuk72	454	4	decreased	decrease	VBD
cord-001859-d62iuk72	454	5	after	after	IN
cord-001859-d62iuk72	454	6	nucleofection	nucleofection	NN
cord-001859-d62iuk72	454	7	.	.	.
cord-001859-d62iuk72	455	1	Similar	similar	JJ
cord-001859-d62iuk72	455	2	impairment	impairment	NN
cord-001859-d62iuk72	455	3	in	in	IN
cord-001859-d62iuk72	455	4	KSHV	KSHV	NNP
cord-001859-d62iuk72	455	5	lytic	lytic	JJ
cord-001859-d62iuk72	455	6	replication	replication	NN
cord-001859-d62iuk72	455	7	has	have	VBZ
cord-001859-d62iuk72	455	8	previously	previously	RB
cord-001859-d62iuk72	455	9	been	be	VBN
cord-001859-d62iuk72	455	10	reported	report	VBN
cord-001859-d62iuk72	455	11	in	in	IN
cord-001859-d62iuk72	455	12	electroporated	electroporated	JJ
cord-001859-d62iuk72	455	13	TREx	TREx	NNPS
cord-001859-d62iuk72	455	14	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	455	15	cells	cell	NNS
cord-001859-d62iuk72	455	16	[	[	-LRB-
cord-001859-d62iuk72	455	17	74	74	CD
cord-001859-d62iuk72	455	18	]	]	-RRB-
cord-001859-d62iuk72	455	19	;	;	:
cord-001859-d62iuk72	455	20	nevertheless	nevertheless	RB
cord-001859-d62iuk72	455	21	,	,	,
cord-001859-d62iuk72	455	22	in	in	IN
cord-001859-d62iuk72	455	23	scramble	scramble	NN
cord-001859-d62iuk72	455	24	siRNA	siRNA	NNP
cord-001859-d62iuk72	455	25	-	-	HYPH
cord-001859-d62iuk72	455	26	treated	treat	VBN
cord-001859-d62iuk72	455	27	cells	cell	NNS
cord-001859-d62iuk72	455	28	,	,	,
cord-001859-d62iuk72	455	29	groups	group	NNS
cord-001859-d62iuk72	455	30	of	of	IN
cord-001859-d62iuk72	455	31	cells	cell	NNS
cord-001859-d62iuk72	455	32	could	could	MD
cord-001859-d62iuk72	455	33	still	still	RB
cord-001859-d62iuk72	455	34	be	be	VB
cord-001859-d62iuk72	455	35	seen	see	VBN
cord-001859-d62iuk72	455	36	displaying	display	VBG
cord-001859-d62iuk72	455	37	RTCs	rtc	NNS
cord-001859-d62iuk72	455	38	to	to	TO
cord-001859-d62iuk72	455	39	which	which	WDT
cord-001859-d62iuk72	455	40	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	455	41	was	be	VBD
cord-001859-d62iuk72	455	42	relocated	relocate	VBN
cord-001859-d62iuk72	455	43	(	(	-LRB-
cord-001859-d62iuk72	455	44	Fig	Fig	NNP
cord-001859-d62iuk72	455	45	12D	12d	CD
cord-001859-d62iuk72	455	46	)	)	-RRB-
cord-001859-d62iuk72	455	47	.	.	.
cord-001859-d62iuk72	456	1	In	in	IN
cord-001859-d62iuk72	456	2	contrast	contrast	NN
cord-001859-d62iuk72	456	3	,	,	,
cord-001859-d62iuk72	456	4	in	in	IN
cord-001859-d62iuk72	456	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	456	6	siRNA	siRNA	NNP
cord-001859-d62iuk72	456	7	-	-	HYPH
cord-001859-d62iuk72	456	8	treated	treat	VBN
cord-001859-d62iuk72	456	9	cells	cell	NNS
cord-001859-d62iuk72	456	10	,	,	,
cord-001859-d62iuk72	456	11	fewer	few	JJR
cord-001859-d62iuk72	456	12	RTCs	rtc	NNS
cord-001859-d62iuk72	456	13	were	be	VBD
cord-001859-d62iuk72	456	14	visible	visible	JJ
cord-001859-d62iuk72	456	15	and	and	CC
cord-001859-d62iuk72	456	16	these	these	DT
cord-001859-d62iuk72	456	17	exhibited	exhibit	VBN
cord-001859-d62iuk72	456	18	nuclear	nuclear	JJ
cord-001859-d62iuk72	456	19	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	457	1	(	(	-LRB-
cord-001859-d62iuk72	457	2	Fig	Fig	NNP
cord-001859-d62iuk72	457	3	12E	12E	NNP
cord-001859-d62iuk72	457	4	yellow	yellow	JJ
cord-001859-d62iuk72	457	5	arrow	arrow	NN
cord-001859-d62iuk72	457	6	)	)	-RRB-
cord-001859-d62iuk72	457	7	while	while	IN
cord-001859-d62iuk72	457	8	cells	cell	NNS
cord-001859-d62iuk72	457	9	fully	fully	RB
cord-001859-d62iuk72	457	10	depleted	deplete	VBN
cord-001859-d62iuk72	457	11	of	of	IN
cord-001859-d62iuk72	457	12	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	457	13	,	,	,
cord-001859-d62iuk72	457	14	as	as	IN
cord-001859-d62iuk72	457	15	identified	identify	VBN
cord-001859-d62iuk72	457	16	by	by	IN
cord-001859-d62iuk72	457	17	lack	lack	NN
cord-001859-d62iuk72	457	18	of	of	IN
cord-001859-d62iuk72	457	19	Hsc70-labelling	hsc70-labelling	NN
cord-001859-d62iuk72	457	20	,	,	,
cord-001859-d62iuk72	457	21	did	do	VBD
cord-001859-d62iuk72	457	22	not	not	RB
cord-001859-d62iuk72	457	23	form	form	VB
cord-001859-d62iuk72	457	24	RTCs	rtc	NNS
cord-001859-d62iuk72	458	1	(	(	-LRB-
cord-001859-d62iuk72	458	2	Fig	Fig	NNP
cord-001859-d62iuk72	458	3	12D	12d	CD
cord-001859-d62iuk72	458	4	 	 	_SP
cord-001859-d62iuk72	458	5	white	white	JJ
cord-001859-d62iuk72	458	6	arrows	arrow	NNS
cord-001859-d62iuk72	458	7	)	)	-RRB-
cord-001859-d62iuk72	458	8	.	.	.
cord-001859-d62iuk72	459	1	This	this	DT
cord-001859-d62iuk72	459	2	result	result	NN
cord-001859-d62iuk72	459	3	strongly	strongly	RB
cord-001859-d62iuk72	459	4	suggests	suggest	VBZ
cord-001859-d62iuk72	459	5	that	that	IN
cord-001859-d62iuk72	459	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	459	7	is	be	VBZ
cord-001859-d62iuk72	459	8	an	an	DT
cord-001859-d62iuk72	459	9	essential	essential	JJ
cord-001859-d62iuk72	459	10	chaperone	chaperone	NN
cord-001859-d62iuk72	459	11	for	for	IN
cord-001859-d62iuk72	459	12	the	the	DT
cord-001859-d62iuk72	459	13	formation	formation	NN
cord-001859-d62iuk72	459	14	of	of	IN
cord-001859-d62iuk72	459	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	459	16	RTCs	rtc	NNS
cord-001859-d62iuk72	459	17	in	in	IN
cord-001859-d62iuk72	459	18	TREx	TREx	NNS
cord-001859-d62iuk72	459	19	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	459	20	cells	cell	NNS
cord-001859-d62iuk72	459	21	.	.	.
cord-001859-d62iuk72	460	1	Current	current	JJ
cord-001859-d62iuk72	460	2	quantitative	quantitative	JJ
cord-001859-d62iuk72	460	3	proteomics	proteomic	NNS
cord-001859-d62iuk72	460	4	approaches	approach	NNS
cord-001859-d62iuk72	460	5	have	have	VBP
cord-001859-d62iuk72	460	6	become	become	VBN
cord-001859-d62iuk72	460	7	an	an	DT
cord-001859-d62iuk72	460	8	invaluable	invaluable	JJ
cord-001859-d62iuk72	460	9	tool	tool	NN
cord-001859-d62iuk72	460	10	for	for	IN
cord-001859-d62iuk72	460	11	large	large	JJ
cord-001859-d62iuk72	460	12	-	-	HYPH
cord-001859-d62iuk72	460	13	scale	scale	NN
cord-001859-d62iuk72	460	14	,	,	,
cord-001859-d62iuk72	460	15	high	high	JJ
cord-001859-d62iuk72	460	16	-	-	HYPH
cord-001859-d62iuk72	460	17	throughput	throughput	NN
cord-001859-d62iuk72	460	18	identification	identification	NN
cord-001859-d62iuk72	460	19	of	of	IN
cord-001859-d62iuk72	460	20	proteins	protein	NNS
cord-001859-d62iuk72	460	21	in	in	IN
cord-001859-d62iuk72	460	22	complex	complex	JJ
cord-001859-d62iuk72	460	23	biological	biological	JJ
cord-001859-d62iuk72	460	24	samples	sample	NNS
cord-001859-d62iuk72	460	25	.	.	.
cord-001859-d62iuk72	461	1	Moreover	moreover	RB
cord-001859-d62iuk72	461	2	,	,	,
cord-001859-d62iuk72	461	3	advances	advance	VBZ
cord-001859-d62iuk72	461	4	in	in	IN
cord-001859-d62iuk72	461	5	subcellular	subcellular	JJ
cord-001859-d62iuk72	461	6	fractionation	fractionation	NN
cord-001859-d62iuk72	461	7	offer	offer	VBP
cord-001859-d62iuk72	461	8	a	a	DT
cord-001859-d62iuk72	461	9	way	way	NN
cord-001859-d62iuk72	461	10	to	to	TO
cord-001859-d62iuk72	461	11	further	further	RB
cord-001859-d62iuk72	461	12	reduce	reduce	VB
cord-001859-d62iuk72	461	13	the	the	DT
cord-001859-d62iuk72	461	14	complexity	complexity	NN
cord-001859-d62iuk72	461	15	of	of	IN
cord-001859-d62iuk72	461	16	the	the	DT
cord-001859-d62iuk72	461	17	samples	sample	NNS
cord-001859-d62iuk72	461	18	to	to	TO
cord-001859-d62iuk72	461	19	be	be	VB
cord-001859-d62iuk72	461	20	analysed	analyse	VBN
cord-001859-d62iuk72	461	21	by	by	IN
cord-001859-d62iuk72	461	22	LC	LC	NNP
cord-001859-d62iuk72	461	23	-	-	HYPH
cord-001859-d62iuk72	461	24	MS	MS	NNP
cord-001859-d62iuk72	461	25	/	/	SYM
cord-001859-d62iuk72	461	26	MS	MS	NNP
cord-001859-d62iuk72	461	27	,	,	,
cord-001859-d62iuk72	461	28	allowing	allow	VBG
cord-001859-d62iuk72	461	29	identification	identification	NN
cord-001859-d62iuk72	461	30	of	of	IN
cord-001859-d62iuk72	461	31	low	low	JJ
cord-001859-d62iuk72	461	32	abundance	abundance	NN
cord-001859-d62iuk72	461	33	proteins	protein	NNS
cord-001859-d62iuk72	461	34	.	.	.
cord-001859-d62iuk72	462	1	In	in	IN
cord-001859-d62iuk72	462	2	this	this	DT
cord-001859-d62iuk72	462	3	present	present	JJ
cord-001859-d62iuk72	462	4	study	study	NN
cord-001859-d62iuk72	462	5	,	,	,
cord-001859-d62iuk72	462	6	we	-PRON-	PRP
cord-001859-d62iuk72	462	7	have	have	VBP
cord-001859-d62iuk72	462	8	developed	develop	VBN
cord-001859-d62iuk72	462	9	a	a	DT
cord-001859-d62iuk72	462	10	novel	novel	JJ
cord-001859-d62iuk72	462	11	quantitative	quantitative	JJ
cord-001859-d62iuk72	462	12	proteomic	proteomic	JJ
cord-001859-d62iuk72	462	13	approach	approach	NN
cord-001859-d62iuk72	462	14	enhanced	enhance	VBN
cord-001859-d62iuk72	462	15	by	by	IN
cord-001859-d62iuk72	462	16	subcellular	subcellular	JJ
cord-001859-d62iuk72	462	17	fractionation	fractionation	NN
cord-001859-d62iuk72	462	18	that	that	WDT
cord-001859-d62iuk72	462	19	has	have	VBZ
cord-001859-d62iuk72	462	20	enabled	enable	VBN
cord-001859-d62iuk72	462	21	us	-PRON-	PRP
cord-001859-d62iuk72	462	22	to	to	TO
cord-001859-d62iuk72	462	23	elucidate	elucidate	VB
cord-001859-d62iuk72	462	24	the	the	DT
cord-001859-d62iuk72	462	25	cellular	cellular	JJ
cord-001859-d62iuk72	462	26	protein	protein	NN
cord-001859-d62iuk72	462	27	composition	composition	NN
cord-001859-d62iuk72	462	28	of	of	IN
cord-001859-d62iuk72	462	29	KSHV	KSHV	NNP
cord-001859-d62iuk72	462	30	RTCs	RTCs	NNP
cord-001859-d62iuk72	462	31	.	.	.
cord-001859-d62iuk72	463	1	This	this	DT
cord-001859-d62iuk72	463	2	novel	novel	JJ
cord-001859-d62iuk72	463	3	approach	approach	NN
cord-001859-d62iuk72	463	4	led	lead	VBD
cord-001859-d62iuk72	463	5	to	to	IN
cord-001859-d62iuk72	463	6	the	the	DT
cord-001859-d62iuk72	463	7	identification	identification	NN
cord-001859-d62iuk72	463	8	of	of	IN
cord-001859-d62iuk72	463	9	several	several	JJ
cord-001859-d62iuk72	463	10	upregulated	upregulate	VBN
cord-001859-d62iuk72	463	11	pathways	pathway	NNS
cord-001859-d62iuk72	463	12	in	in	IN
cord-001859-d62iuk72	463	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	463	14	cells	cell	NNS
cord-001859-d62iuk72	463	15	associated	associate	VBN
cord-001859-d62iuk72	463	16	with	with	IN
cord-001859-d62iuk72	463	17	the	the	DT
cord-001859-d62iuk72	463	18	NE	NE	NNP
cord-001859-d62iuk72	463	19	fraction	fraction	NN
cord-001859-d62iuk72	463	20	(	(	-LRB-
cord-001859-d62iuk72	463	21	S2	S2	NNP
cord-001859-d62iuk72	463	22	Table	Table	NNP
cord-001859-d62iuk72	463	23	)	)	-RRB-
cord-001859-d62iuk72	463	24	.	.	.
cord-001859-d62iuk72	464	1	The	the	DT
cord-001859-d62iuk72	464	2	first	first	JJ
cord-001859-d62iuk72	464	3	scored	score	VBN
cord-001859-d62iuk72	464	4	pathway	pathway	NN
cord-001859-d62iuk72	464	5	was	be	VBD
cord-001859-d62iuk72	464	6	RNA	RNA	NNP
cord-001859-d62iuk72	464	7	post	post	JJ
cord-001859-d62iuk72	464	8	-	-	JJ
cord-001859-d62iuk72	464	9	transcriptional	transcriptional	JJ
cord-001859-d62iuk72	464	10	modification	modification	NN
cord-001859-d62iuk72	464	11	,	,	,
cord-001859-d62iuk72	464	12	the	the	DT
cord-001859-d62iuk72	464	13	second	second	JJ
cord-001859-d62iuk72	464	14	highlighted	highlighted	JJ
cord-001859-d62iuk72	464	15	pathway	pathway	NN
cord-001859-d62iuk72	464	16	was	be	VBD
cord-001859-d62iuk72	464	17	protein	protein	NN
cord-001859-d62iuk72	464	18	synthesis	synthesis	NN
cord-001859-d62iuk72	464	19	with	with	IN
cord-001859-d62iuk72	464	20	26	26	CD
cord-001859-d62iuk72	464	21	different	different	JJ
cord-001859-d62iuk72	464	22	ribosomal	ribosomal	JJ
cord-001859-d62iuk72	464	23	proteins	protein	NNS
cord-001859-d62iuk72	464	24	identified	identify	VBN
cord-001859-d62iuk72	464	25	and	and	CC
cord-001859-d62iuk72	464	26	the	the	DT
cord-001859-d62iuk72	464	27	third	third	JJ
cord-001859-d62iuk72	464	28	scored	scored	JJ
cord-001859-d62iuk72	464	29	pathway	pathway	NN
cord-001859-d62iuk72	464	30	was	be	VBD
cord-001859-d62iuk72	464	31	DNA	dna	NN
cord-001859-d62iuk72	464	32	replication	replication	NN
cord-001859-d62iuk72	464	33	,	,	,
cord-001859-d62iuk72	464	34	recombination	recombination	NN
cord-001859-d62iuk72	464	35	and	and	CC
cord-001859-d62iuk72	464	36	repair	repair	NN
cord-001859-d62iuk72	464	37	.	.	.
cord-001859-d62iuk72	465	1	In	in	IN
cord-001859-d62iuk72	465	2	addition	addition	NN
cord-001859-d62iuk72	465	3	,	,	,
cord-001859-d62iuk72	465	4	the	the	DT
cord-001859-d62iuk72	465	5	isolation	isolation	NN
cord-001859-d62iuk72	465	6	of	of	IN
cord-001859-d62iuk72	465	7	the	the	DT
cord-001859-d62iuk72	465	8	NE	NE	NNP
cord-001859-d62iuk72	465	9	regions	region	NNS
cord-001859-d62iuk72	465	10	from	from	IN
cord-001859-d62iuk72	465	11	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	465	12	and	and	CC
cord-001859-d62iuk72	465	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	465	14	cells	cell	NNS
cord-001859-d62iuk72	465	15	followed	follow	VBN
cord-001859-d62iuk72	465	16	by	by	IN
cord-001859-d62iuk72	465	17	the	the	DT
cord-001859-d62iuk72	465	18	uncommon	uncommon	JJ
cord-001859-d62iuk72	465	19	use	use	NN
cord-001859-d62iuk72	465	20	of	of	IN
cord-001859-d62iuk72	465	21	urea	urea	NN
cord-001859-d62iuk72	465	22	for	for	IN
cord-001859-d62iuk72	465	23	protein	protein	NN
cord-001859-d62iuk72	465	24	extraction	extraction	NN
cord-001859-d62iuk72	465	25	led	lead	VBD
cord-001859-d62iuk72	465	26	to	to	IN
cord-001859-d62iuk72	465	27	the	the	DT
cord-001859-d62iuk72	465	28	mass	mass	NNP
cord-001859-d62iuk72	465	29	spectrometric	spectrometric	NNP
cord-001859-d62iuk72	465	30	identification	identification	NN
cord-001859-d62iuk72	465	31	of	of	IN
cord-001859-d62iuk72	465	32	several	several	JJ
cord-001859-d62iuk72	465	33	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	465	34	isoforms	isoform	NNS
cord-001859-d62iuk72	465	35	and	and	CC
cord-001859-d62iuk72	465	36	their	-PRON-	PRP$
cord-001859-d62iuk72	465	37	respective	respective	JJ
cord-001859-d62iuk72	465	38	co	co	NNS
cord-001859-d62iuk72	465	39	-	-	NNS
cord-001859-d62iuk72	465	40	chaperones	chaperone	NNS
cord-001859-d62iuk72	465	41	at	at	IN
cord-001859-d62iuk72	465	42	significant	significant	JJ
cord-001859-d62iuk72	465	43	levels	level	NNS
cord-001859-d62iuk72	465	44	in	in	IN
cord-001859-d62iuk72	465	45	NE	NE	NNP
cord-001859-d62iuk72	465	46	-	-	HYPH
cord-001859-d62iuk72	465	47	associated	associate	VBN
cord-001859-d62iuk72	465	48	RTCs	rtc	NNS
cord-001859-d62iuk72	465	49	of	of	IN
cord-001859-d62iuk72	465	50	reactivated	reactivate	VBN
cord-001859-d62iuk72	465	51	cells	cell	NNS
cord-001859-d62iuk72	465	52	.	.	.
cord-001859-d62iuk72	466	1	Immunoflourescence	Immunoflourescence	NNP
cord-001859-d62iuk72	466	2	analysis	analysis	NN
cord-001859-d62iuk72	466	3	confirmed	confirm	VBD
cord-001859-d62iuk72	466	4	that	that	IN
cord-001859-d62iuk72	466	5	endogenous	endogenous	JJ
cord-001859-d62iuk72	466	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	466	7	and	and	CC
cord-001859-d62iuk72	466	8	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	466	9	were	be	VBD
cord-001859-d62iuk72	466	10	redistributed	redistribute	VBN
cord-001859-d62iuk72	466	11	from	from	IN
cord-001859-d62iuk72	466	12	the	the	DT
cord-001859-d62iuk72	466	13	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	466	14	to	to	IN
cord-001859-d62iuk72	466	15	the	the	DT
cord-001859-d62iuk72	466	16	periphery	periphery	NN
cord-001859-d62iuk72	466	17	of	of	IN
cord-001859-d62iuk72	466	18	KSHV	KSHV	NNP
cord-001859-d62iuk72	466	19	RTCs	rtc	NNS
cord-001859-d62iuk72	466	20	where	where	WRB
cord-001859-d62iuk72	466	21	they	-PRON-	PRP
cord-001859-d62iuk72	466	22	formed	form	VBD
cord-001859-d62iuk72	466	23	multiple	multiple	JJ
cord-001859-d62iuk72	466	24	nuclear	nuclear	JJ
cord-001859-d62iuk72	466	25	foci	foci	NN
cord-001859-d62iuk72	466	26	during	during	IN
cord-001859-d62iuk72	466	27	early	early	JJ
cord-001859-d62iuk72	466	28	lytic	lytic	JJ
cord-001859-d62iuk72	466	29	replication	replication	NN
cord-001859-d62iuk72	466	30	.	.	.
cord-001859-d62iuk72	467	1	The	the	DT
cord-001859-d62iuk72	467	2	formation	formation	NN
cord-001859-d62iuk72	467	3	of	of	IN
cord-001859-d62iuk72	467	4	RTCs	RTCs	NNP
cord-001859-d62iuk72	467	5	coincided	coincide	VBN
cord-001859-d62iuk72	467	6	in	in	IN
cord-001859-d62iuk72	467	7	time	time	NN
cord-001859-d62iuk72	467	8	with	with	IN
cord-001859-d62iuk72	467	9	the	the	DT
cord-001859-d62iuk72	467	10	appearance	appearance	NN
cord-001859-d62iuk72	467	11	of	of	IN
cord-001859-d62iuk72	467	12	nuclear	nuclear	JJ
cord-001859-d62iuk72	467	13	chaperone	chaperone	NN
cord-001859-d62iuk72	467	14	foci	foci	NN
cord-001859-d62iuk72	467	15	.	.	.
cord-001859-d62iuk72	468	1	Similar	similar	JJ
cord-001859-d62iuk72	468	2	virus	virus	NN
cord-001859-d62iuk72	468	3	-	-	HYPH
cord-001859-d62iuk72	468	4	induced	induce	VBN
cord-001859-d62iuk72	468	5	-	-	HYPH
cord-001859-d62iuk72	468	6	chaperone	chaperone	NN
cord-001859-d62iuk72	468	7	-	-	HYPH
cord-001859-d62iuk72	468	8	enriched	enrich	VBN
cord-001859-d62iuk72	468	9	(	(	-LRB-
cord-001859-d62iuk72	468	10	VICE	vice	NN
cord-001859-d62iuk72	468	11	)	)	-RRB-
cord-001859-d62iuk72	468	12	domains	domain	NNS
cord-001859-d62iuk72	468	13	that	that	WDT
cord-001859-d62iuk72	468	14	form	form	VBP
cord-001859-d62iuk72	468	15	adjacent	adjacent	JJ
cord-001859-d62iuk72	468	16	to	to	IN
cord-001859-d62iuk72	468	17	HSV-1	hsv-1	NN
cord-001859-d62iuk72	468	18	RTCs	rtc	NNS
cord-001859-d62iuk72	468	19	,	,	,
cord-001859-d62iuk72	468	20	have	have	VBP
cord-001859-d62iuk72	468	21	also	also	RB
cord-001859-d62iuk72	468	22	been	be	VBN
cord-001859-d62iuk72	468	23	observed	observe	VBN
cord-001859-d62iuk72	468	24	in	in	IN
cord-001859-d62iuk72	468	25	HSV-1-infected	hsv-1-infecte	VBN
cord-001859-d62iuk72	468	26	cells	cell	NNS
cord-001859-d62iuk72	468	27	and	and	CC
cord-001859-d62iuk72	468	28	contain	contain	VBP
cord-001859-d62iuk72	468	29	sequestered	sequester	VBN
cord-001859-d62iuk72	468	30	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	468	31	,	,	,
cord-001859-d62iuk72	468	32	iHsp70	ihsp70	ADD
cord-001859-d62iuk72	468	33	,	,	,
cord-001859-d62iuk72	468	34	Hsp40	Hsp40	NNP
cord-001859-d62iuk72	468	35	and	and	CC
cord-001859-d62iuk72	468	36	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	468	37	[	[	-LRB-
cord-001859-d62iuk72	468	38	58	58	CD
cord-001859-d62iuk72	468	39	,	,	,
cord-001859-d62iuk72	468	40	75	75	CD
cord-001859-d62iuk72	468	41	,	,	,
cord-001859-d62iuk72	468	42	76	76	CD
cord-001859-d62iuk72	468	43	]	]	-RRB-
cord-001859-d62iuk72	468	44	.	.	.
cord-001859-d62iuk72	469	1	HSV-1	hsv-1	NN
cord-001859-d62iuk72	469	2	induced	induce	VBN
cord-001859-d62iuk72	469	3	-	-	HYPH
cord-001859-d62iuk72	469	4	VICE	vice	NN
cord-001859-d62iuk72	469	5	domains	domain	NNS
cord-001859-d62iuk72	469	6	also	also	RB
cord-001859-d62iuk72	469	7	accumulate	accumulate	VBP
cord-001859-d62iuk72	469	8	ubiquitinated	ubiquitinated	JJ
cord-001859-d62iuk72	469	9	proteins	protein	NNS
cord-001859-d62iuk72	469	10	and	and	CC
cord-001859-d62iuk72	469	11	components	component	NNS
cord-001859-d62iuk72	469	12	of	of	IN
cord-001859-d62iuk72	469	13	the	the	DT
cord-001859-d62iuk72	469	14	proteasome	proteasome	NN
cord-001859-d62iuk72	469	15	and	and	CC
cord-001859-d62iuk72	469	16	function	function	NN
cord-001859-d62iuk72	469	17	to	to	TO
cord-001859-d62iuk72	469	18	sequester	sequester	VB
cord-001859-d62iuk72	469	19	misfolded	misfolded	JJ
cord-001859-d62iuk72	469	20	proteins	protein	NNS
cord-001859-d62iuk72	469	21	away	away	RB
cord-001859-d62iuk72	469	22	from	from	IN
cord-001859-d62iuk72	469	23	RTCs	rtc	NNS
cord-001859-d62iuk72	469	24	and	and	CC
cord-001859-d62iuk72	469	25	serve	serve	VB
cord-001859-d62iuk72	469	26	as	as	IN
cord-001859-d62iuk72	469	27	protein	protein	NN
cord-001859-d62iuk72	469	28	quality	quality	NN
cord-001859-d62iuk72	469	29	control	control	NN
cord-001859-d62iuk72	469	30	centers	center	NNS
cord-001859-d62iuk72	469	31	[	[	-LRB-
cord-001859-d62iuk72	469	32	75	75	CD
cord-001859-d62iuk72	469	33	,	,	,
cord-001859-d62iuk72	469	34	77	77	CD
cord-001859-d62iuk72	469	35	]	]	-RRB-
cord-001859-d62iuk72	469	36	.	.	.
cord-001859-d62iuk72	470	1	iHsp70	iHsp70	.
cord-001859-d62iuk72	471	1	redistribution	redistribution	NN
cord-001859-d62iuk72	471	2	very	very	RB
cord-001859-d62iuk72	471	3	similar	similar	JJ
cord-001859-d62iuk72	471	4	to	to	IN
cord-001859-d62iuk72	471	5	that	that	DT
cord-001859-d62iuk72	471	6	seen	see	VBN
cord-001859-d62iuk72	471	7	in	in	IN
cord-001859-d62iuk72	471	8	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	471	9	induced	induce	VBN
cord-001859-d62iuk72	471	10	-	-	HYPH
cord-001859-d62iuk72	471	11	VICE	vice	NN
cord-001859-d62iuk72	471	12	domains	domain	NNS
cord-001859-d62iuk72	471	13	was	be	VBD
cord-001859-d62iuk72	471	14	observed	observe	VBN
cord-001859-d62iuk72	471	15	in	in	IN
cord-001859-d62iuk72	471	16	multiple	multiple	JJ
cord-001859-d62iuk72	471	17	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	471	18	and	and	CC
cord-001859-d62iuk72	471	19	total	total	JJ
cord-001859-d62iuk72	471	20	RNA	RNA	NNP
cord-001859-d62iuk72	471	21	and	and	CC
cord-001859-d62iuk72	471	22	protein	protein	NN
cord-001859-d62iuk72	471	23	were	be	VBD
cord-001859-d62iuk72	471	24	extracted	extract	VBN
cord-001859-d62iuk72	471	25	from	from	IN
cord-001859-d62iuk72	471	26	the	the	DT
cord-001859-d62iuk72	471	27	same	same	JJ
cord-001859-d62iuk72	471	28	sample	sample	NN
cord-001859-d62iuk72	471	29	.	.	.
cord-001859-d62iuk72	472	1	Despite	despite	IN
cord-001859-d62iuk72	472	2	achieving~85	achieving~85	NNP
cord-001859-d62iuk72	472	3	%	%	NN
cord-001859-d62iuk72	472	4	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	472	5	knockdown	knockdown	NN
cord-001859-d62iuk72	472	6	at	at	IN
cord-001859-d62iuk72	472	7	the	the	DT
cord-001859-d62iuk72	472	8	mRNA	mRNA	NNP
cord-001859-d62iuk72	472	9	level	level	NN
cord-001859-d62iuk72	472	10	(	(	-LRB-
cord-001859-d62iuk72	472	11	A	a	NN
cord-001859-d62iuk72	472	12	)	)	-RRB-
cord-001859-d62iuk72	472	13	,	,	,
cord-001859-d62iuk72	472	14	significant	significant	JJ
cord-001859-d62iuk72	472	15	amounts	amount	NNS
cord-001859-d62iuk72	472	16	of	of	IN
cord-001859-d62iuk72	472	17	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	472	18	protein	protein	NN
cord-001859-d62iuk72	472	19	remained	remain	VBD
cord-001859-d62iuk72	472	20	in	in	IN
cord-001859-d62iuk72	472	21	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	472	22	siRNA	siRNA	NNP
cord-001859-d62iuk72	472	23	-	-	HYPH
cord-001859-d62iuk72	472	24	treated	treat	VBN
cord-001859-d62iuk72	472	25	samples	sample	NNS
cord-001859-d62iuk72	472	26	(	(	-LRB-
cord-001859-d62iuk72	472	27	B	b	NN
cord-001859-d62iuk72	472	28	)	)	-RRB-
cord-001859-d62iuk72	472	29	.	.	.
cord-001859-d62iuk72	473	1	Despite	despite	IN
cord-001859-d62iuk72	473	2	this	this	DT
cord-001859-d62iuk72	473	3	small	small	JJ
cord-001859-d62iuk72	473	4	knockdown	knockdown	NN
cord-001859-d62iuk72	473	5	at	at	IN
cord-001859-d62iuk72	473	6	the	the	DT
cord-001859-d62iuk72	473	7	protein	protein	NN
cord-001859-d62iuk72	473	8	level	level	NN
cord-001859-d62iuk72	473	9	,	,	,
cord-001859-d62iuk72	473	10	in	in	IN
cord-001859-d62iuk72	473	11	Hsc70-depleted	hsc70-deplete	VBN
cord-001859-d62iuk72	473	12	cells	cell	NNS
cord-001859-d62iuk72	473	13	there	there	EX
cord-001859-d62iuk72	473	14	was	be	VBD
cord-001859-d62iuk72	473	15	a	a	DT
cord-001859-d62iuk72	473	16	significant	significant	JJ
cord-001859-d62iuk72	473	17	decrease	decrease	NN
cord-001859-d62iuk72	473	18	in	in	IN
cord-001859-d62iuk72	473	19	the	the	DT
cord-001859-d62iuk72	473	20	amount	amount	NN
cord-001859-d62iuk72	473	21	of	of	IN
cord-001859-d62iuk72	473	22	multiple	multiple	JJ
cord-001859-d62iuk72	473	23	viral	viral	JJ
cord-001859-d62iuk72	473	24	transcripts	transcript	NNS
cord-001859-d62iuk72	473	25	from	from	IN
cord-001859-d62iuk72	473	26	various	various	JJ
cord-001859-d62iuk72	473	27	temporal	temporal	JJ
cord-001859-d62iuk72	473	28	classes	class	NNS
cord-001859-d62iuk72	473	29	as	as	IN
cord-001859-d62iuk72	473	30	quantified	quantify	VBN
cord-001859-d62iuk72	473	31	by	by	IN
cord-001859-d62iuk72	473	32	RT	RT	NNP
cord-001859-d62iuk72	473	33	-	-	HYPH
cord-001859-d62iuk72	473	34	PCR	PCR	NNP
cord-001859-d62iuk72	473	35	analysis	analysis	NN
cord-001859-d62iuk72	473	36	(	(	-LRB-
cord-001859-d62iuk72	473	37	C	C	NNP
cord-001859-d62iuk72	473	38	)	)	-RRB-
cord-001859-d62iuk72	473	39	.	.	.
cord-001859-d62iuk72	474	1	Viral	viral	JJ
cord-001859-d62iuk72	474	2	DNA	dna	NN
cord-001859-d62iuk72	474	3	replication	replication	NN
cord-001859-d62iuk72	474	4	was	be	VBD
cord-001859-d62iuk72	474	5	assessed	assess	VBN
cord-001859-d62iuk72	474	6	by	by	IN
cord-001859-d62iuk72	474	7	qPCR	qpcr	NN
cord-001859-d62iuk72	474	8	following	follow	VBG
cord-001859-d62iuk72	474	9	Hsc70-knockdown	hsc70-knockdown	JJ
cord-001859-d62iuk72	474	10	.	.	.
cord-001859-d62iuk72	475	1	Cells	cell	NNS
cord-001859-d62iuk72	475	2	were	be	VBD
cord-001859-d62iuk72	475	3	reactivated	reactivate	VBN
cord-001859-d62iuk72	475	4	for	for	IN
cord-001859-d62iuk72	475	5	72	72	CD
cord-001859-d62iuk72	475	6	h	h	NN
cord-001859-d62iuk72	475	7	after	after	IN
cord-001859-d62iuk72	475	8	four	four	CD
cord-001859-d62iuk72	475	9	days	day	NNS
cord-001859-d62iuk72	475	10	post	post	NN
cord-001859-d62iuk72	475	11	-	-	JJ
cord-001859-d62iuk72	475	12	siRNA	sirna	JJ
cord-001859-d62iuk72	475	13	transfection	transfection	NN
cord-001859-d62iuk72	475	14	.	.	.
cord-001859-d62iuk72	476	1	No	no	DT
cord-001859-d62iuk72	476	2	significant	significant	JJ
cord-001859-d62iuk72	476	3	differences	difference	NNS
cord-001859-d62iuk72	476	4	were	be	VBD
cord-001859-d62iuk72	476	5	observed	observe	VBN
cord-001859-d62iuk72	476	6	between	between	IN
cord-001859-d62iuk72	476	7	scramble	scramble	NN
cord-001859-d62iuk72	476	8	and	and	CC
cord-001859-d62iuk72	476	9	Hsc70-treated	hsc70-treate	VBN
cord-001859-d62iuk72	476	10	cells	cell	NNS
cord-001859-d62iuk72	476	11	(	(	-LRB-
cord-001859-d62iuk72	476	12	D	D	NNP
cord-001859-d62iuk72	476	13	)	)	-RRB-
cord-001859-d62iuk72	476	14	.	.	.
cord-001859-d62iuk72	477	1	Similar	similar	JJ
cord-001859-d62iuk72	477	2	virion	virion	NN
cord-001859-d62iuk72	477	3	production	production	NN
cord-001859-d62iuk72	477	4	was	be	VBD
cord-001859-d62iuk72	477	5	detected	detect	VBN
cord-001859-d62iuk72	477	6	in	in	IN
cord-001859-d62iuk72	477	7	scramble	scramble	NN
cord-001859-d62iuk72	477	8	and	and	CC
cord-001859-d62iuk72	477	9	Hsc70-treated	hsc70-treate	VBN
cord-001859-d62iuk72	477	10	cells	cell	NNS
cord-001859-d62iuk72	477	11	.	.	.
cord-001859-d62iuk72	478	1	Cells	cell	NNS
cord-001859-d62iuk72	478	2	were	be	VBD
cord-001859-d62iuk72	478	3	reactivated	reactivate	VBN
cord-001859-d62iuk72	478	4	for	for	IN
cord-001859-d62iuk72	478	5	72	72	CD
cord-001859-d62iuk72	478	6	h	h	NN
cord-001859-d62iuk72	478	7	after	after	IN
cord-001859-d62iuk72	478	8	four	four	CD
cord-001859-d62iuk72	478	9	days	day	NNS
cord-001859-d62iuk72	478	10	post	post	NN
cord-001859-d62iuk72	478	11	-	-	JJ
cord-001859-d62iuk72	478	12	siRNA	sirna	JJ
cord-001859-d62iuk72	478	13	transfection	transfection	NN
cord-001859-d62iuk72	478	14	,	,	,
cord-001859-d62iuk72	478	15	culture	culture	NN
cord-001859-d62iuk72	478	16	medium	medium	NN
cord-001859-d62iuk72	478	17	was	be	VBD
cord-001859-d62iuk72	478	18	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	478	19	and	and	CC
cord-001859-d62iuk72	478	20	immediately	immediately	RB
cord-001859-d62iuk72	478	21	incubated	incubate	VBD
cord-001859-d62iuk72	478	22	with	with	IN
cord-001859-d62iuk72	478	23	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	478	24	T	T	NNP
cord-001859-d62iuk72	478	25	cells	cell	NNS
cord-001859-d62iuk72	478	26	for	for	IN
cord-001859-d62iuk72	478	27	24	24	CD
cord-001859-d62iuk72	478	28	h.	h.	NNP
cord-001859-d62iuk72	478	29	Total	Total	NNP
cord-001859-d62iuk72	478	30	RNA	RNA	NNP
cord-001859-d62iuk72	478	31	was	be	VBD
cord-001859-d62iuk72	478	32	then	then	RB
cord-001859-d62iuk72	478	33	isolated	isolate	VBN
cord-001859-d62iuk72	478	34	and	and	CC
cord-001859-d62iuk72	478	35	qRT	qRT	NNP
cord-001859-d62iuk72	478	36	-	-	HYPH
cord-001859-d62iuk72	478	37	PCR	PCR	NNP
cord-001859-d62iuk72	478	38	carried	carry	VBD
cord-001859-d62iuk72	478	39	out	out	RP
cord-001859-d62iuk72	478	40	(	(	-LRB-
cord-001859-d62iuk72	478	41	E	e	NN
cord-001859-d62iuk72	478	42	)	)	-RRB-
cord-001859-d62iuk72	478	43	.	.	.
cord-001859-d62iuk72	479	1	Incomplete	incomplete	JJ
cord-001859-d62iuk72	479	2	Hsc70-knockdown	hsc70-knockdown	JJ
cord-001859-d62iuk72	479	3	at	at	IN
cord-001859-d62iuk72	479	4	the	the	DT
cord-001859-d62iuk72	479	5	protein	protein	NN
cord-001859-d62iuk72	479	6	level	level	NN
cord-001859-d62iuk72	479	7	was	be	VBD
cord-001859-d62iuk72	479	8	observed	observe	VBN
cord-001859-d62iuk72	479	9	by	by	IN
cord-001859-d62iuk72	479	10	Western	western	JJ
cord-001859-d62iuk72	479	11	blotting	blotting	NN
cord-001859-d62iuk72	479	12	even	even	RB
cord-001859-d62iuk72	479	13	after	after	IN
cord-001859-d62iuk72	479	14	seven	seven	CD
cord-001859-d62iuk72	479	15	days	day	NNS
cord-001859-d62iuk72	479	16	post	post	NN
cord-001859-d62iuk72	479	17	-	-	JJ
cord-001859-d62iuk72	479	18	siRNA	sirna	JJ
cord-001859-d62iuk72	479	19	transfection	transfection	NN
cord-001859-d62iuk72	479	20	in	in	IN
cord-001859-d62iuk72	479	21	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	479	22	T	t	NN
cord-001859-d62iuk72	479	23	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	479	24	cells	cell	NNS
cord-001859-d62iuk72	479	25	.	.	.
cord-001859-d62iuk72	480	1	This	this	DT
cord-001859-d62iuk72	480	2	demonstrates	demonstrate	VBZ
cord-001859-d62iuk72	480	3	the	the	DT
cord-001859-d62iuk72	480	4	remarkable	remarkable	JJ
cord-001859-d62iuk72	480	5	stability	stability	NN
cord-001859-d62iuk72	480	6	of	of	IN
cord-001859-d62iuk72	480	7	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	480	8	in	in	IN
cord-001859-d62iuk72	480	9	this	this	DT
cord-001859-d62iuk72	480	10	cell	cell	NN
cord-001859-d62iuk72	480	11	line	line	NN
cord-001859-d62iuk72	480	12	(	(	-LRB-
cord-001859-d62iuk72	480	13	F	F	NNP
cord-001859-d62iuk72	480	14	)	)	-RRB-
cord-001859-d62iuk72	480	15	.	.	.
cord-001859-d62iuk72	481	1	The	the	DT
cord-001859-d62iuk72	481	2	average	average	NN
cord-001859-d62iuk72	481	3	of	of	IN
cord-001859-d62iuk72	481	4	three	three	CD
cord-001859-d62iuk72	481	5	independent	independent	JJ
cord-001859-d62iuk72	481	6	transfections	transfection	NNS
cord-001859-d62iuk72	481	7	is	be	VBZ
cord-001859-d62iuk72	481	8	shown	show	VBN
cord-001859-d62iuk72	481	9	with	with	IN
cord-001859-d62iuk72	481	10	error	error	NN
cord-001859-d62iuk72	481	11	bars	bar	NNS
cord-001859-d62iuk72	481	12	as	as	IN
cord-001859-d62iuk72	481	13	standard	standard	JJ
cord-001859-d62iuk72	481	14	deviation	deviation	NN
cord-001859-d62iuk72	481	15	(	(	-LRB-
cord-001859-d62iuk72	481	16	A	A	NNP
cord-001859-d62iuk72	481	17	,	,	,
cord-001859-d62iuk72	481	18	C	c	NN
cord-001859-d62iuk72	481	19	-	-	HYPH
cord-001859-d62iuk72	481	20	E	E	NNP
cord-001859-d62iuk72	481	21	)	)	-RRB-
cord-001859-d62iuk72	481	22	.	.	.
cord-001859-d62iuk72	482	1	doi:10.1371	doi:10.1371	NNP
cord-001859-d62iuk72	483	1	/journal.ppat.1005274.g010	/journal.ppat.1005274.g010	.
cord-001859-d62iuk72	483	2	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	483	3	Isoforms	Isoforms	NNP
cord-001859-d62iuk72	483	4	Are	be	VBP
cord-001859-d62iuk72	483	5	Essential	essential	JJ
cord-001859-d62iuk72	483	6	for	for	IN
cord-001859-d62iuk72	483	7	KSHV	KSHV	NNP
cord-001859-d62iuk72	483	8	Lytic	Lytic	NNP
cord-001859-d62iuk72	483	9	Replication	Replication	NNP
cord-001859-d62iuk72	483	10	 	 	_SP
cord-001859-d62iuk72	483	11	Fig	Fig	NNP
cord-001859-d62iuk72	483	12	11	11	CD
cord-001859-d62iuk72	483	13	.	.	.
cord-001859-d62iuk72	484	1	The	the	DT
cord-001859-d62iuk72	484	2	majority	majority	NN
cord-001859-d62iuk72	484	3	of	of	IN
cord-001859-d62iuk72	484	4	KSHV	KSHV	NNP
cord-001859-d62iuk72	484	5	lytic	lytic	JJ
cord-001859-d62iuk72	484	6	gene	gene	NN
cord-001859-d62iuk72	484	7	expression	expression	NN
cord-001859-d62iuk72	484	8	was	be	VBD
cord-001859-d62iuk72	484	9	unaffected	unaffected	JJ
cord-001859-d62iuk72	484	10	following	follow	VBG
cord-001859-d62iuk72	484	11	specific	specific	JJ
cord-001859-d62iuk72	484	12	depletion	depletion	NN
cord-001859-d62iuk72	484	13	of	of	IN
cord-001859-d62iuk72	484	14	iHsp70	ihsp70	NN
cord-001859-d62iuk72	484	15	in	in	IN
cord-001859-d62iuk72	484	16	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	484	17	T	t	NN
cord-001859-d62iuk72	484	18	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	484	19	cells	cell	NNS
cord-001859-d62iuk72	484	20	.	.	.
cord-001859-d62iuk72	485	1	Cells	cell	NNS
cord-001859-d62iuk72	485	2	were	be	VBD
cord-001859-d62iuk72	485	3	transfected	transfecte	VBN
cord-001859-d62iuk72	485	4	twice	twice	RB
cord-001859-d62iuk72	485	5	with	with	IN
cord-001859-d62iuk72	485	6	100	100	CD
cord-001859-d62iuk72	485	7	nM	nM	NNP
cord-001859-d62iuk72	485	8	iHsp70-specific	iHsp70-specific	NNP
cord-001859-d62iuk72	485	9	siRNA	siRNA	NNP
cord-001859-d62iuk72	485	10	or	or	CC
cord-001859-d62iuk72	486	1	100	100	CD
cord-001859-d62iuk72	486	2	nM	nM	NNP
cord-001859-d62iuk72	486	3	scramble	scramble	NN
cord-001859-d62iuk72	486	4	siRNA	siRNA	NNP
cord-001859-d62iuk72	486	5	.	.	.
cord-001859-d62iuk72	487	1	Following	follow	VBG
cord-001859-d62iuk72	487	2	four	four	CD
cord-001859-d62iuk72	487	3	days	day	NNS
cord-001859-d62iuk72	487	4	post	post	NN
cord-001859-d62iuk72	487	5	-	-	JJ
cord-001859-d62iuk72	487	6	siRNA	sirna	JJ
cord-001859-d62iuk72	487	7	transfection	transfection	NN
cord-001859-d62iuk72	487	8	,	,	,
cord-001859-d62iuk72	487	9	cells	cell	NNS
cord-001859-d62iuk72	487	10	were	be	VBD
cord-001859-d62iuk72	487	11	either	either	CC
cord-001859-d62iuk72	487	12	reactivated	reactivate	VBN
cord-001859-d62iuk72	487	13	cells	cell	NNS
cord-001859-d62iuk72	487	14	undergoing	undergo	VBG
cord-001859-d62iuk72	487	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	487	16	lytic	lytic	JJ
cord-001859-d62iuk72	487	17	replication	replication	NN
cord-001859-d62iuk72	487	18	,	,	,
cord-001859-d62iuk72	487	19	moreover	moreover	RB
cord-001859-d62iuk72	487	20	this	this	DT
cord-001859-d62iuk72	487	21	labelling	labelling	NN
cord-001859-d62iuk72	487	22	was	be	VBD
cord-001859-d62iuk72	487	23	also	also	RB
cord-001859-d62iuk72	487	24	observed	observe	VBN
cord-001859-d62iuk72	487	25	for	for	IN
cord-001859-d62iuk72	487	26	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	487	27	in	in	IN
cord-001859-d62iuk72	487	28	some	some	DT
cord-001859-d62iuk72	487	29	cells	cell	NNS
cord-001859-d62iuk72	487	30	.	.	.
cord-001859-d62iuk72	488	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	488	2	and	and	CC
cord-001859-d62iuk72	488	3	iHsp70	ihsp70	TO
cord-001859-d62iuk72	488	4	remain	remain	VB
cord-001859-d62iuk72	488	5	positioned	position	VBN
cord-001859-d62iuk72	488	6	exclusively	exclusively	RB
cord-001859-d62iuk72	488	7	adjacent	adjacent	JJ
cord-001859-d62iuk72	488	8	to	to	IN
cord-001859-d62iuk72	488	9	HSV-1	hsv-1	NN
cord-001859-d62iuk72	488	10	RTCs	rtc	NNS
cord-001859-d62iuk72	488	11	.	.	.
cord-001859-d62iuk72	489	1	However	however	RB
cord-001859-d62iuk72	489	2	,	,	,
cord-001859-d62iuk72	489	3	in	in	IN
cord-001859-d62iuk72	489	4	contrast	contrast	NN
cord-001859-d62iuk72	489	5	;	;	:
cord-001859-d62iuk72	489	6	these	these	DT
cord-001859-d62iuk72	489	7	chaperones	chaperone	NNS
cord-001859-d62iuk72	489	8	were	be	VBD
cord-001859-d62iuk72	489	9	very	very	RB
cord-001859-d62iuk72	489	10	dynamic	dynamic	JJ
cord-001859-d62iuk72	489	11	during	during	IN
cord-001859-d62iuk72	489	12	KSHV	KSHV	NNP
cord-001859-d62iuk72	489	13	lytic	lytic	JJ
cord-001859-d62iuk72	489	14	replication	replication	NN
cord-001859-d62iuk72	489	15	and	and	CC
cord-001859-d62iuk72	489	16	surprisingly	surprisingly	RB
cord-001859-d62iuk72	489	17	very	very	RB
cord-001859-d62iuk72	489	18	large	large	JJ
cord-001859-d62iuk72	489	19	chaperone	chaperone	NN
cord-001859-d62iuk72	489	20	foci	focus	NNS
cord-001859-d62iuk72	489	21	were	be	VBD
cord-001859-d62iuk72	489	22	recruited	recruit	VBN
cord-001859-d62iuk72	489	23	within	within	IN
cord-001859-d62iuk72	489	24	KSHV	KSHV	NNP
cord-001859-d62iuk72	489	25	RTCs	RTCs	NNP
cord-001859-d62iuk72	489	26	when	when	WRB
cord-001859-d62iuk72	489	27	viral	viral	JJ
cord-001859-d62iuk72	489	28	DNA	dna	NN
cord-001859-d62iuk72	489	29	was	be	VBD
cord-001859-d62iuk72	489	30	actively	actively	RB
cord-001859-d62iuk72	489	31	synthesised	synthesise	VBN
cord-001859-d62iuk72	489	32	(	(	-LRB-
cord-001859-d62iuk72	489	33	Fig	Fig	NNP
cord-001859-d62iuk72	489	34	2C	2c	NN
cord-001859-d62iuk72	489	35	and	and	CC
cord-001859-d62iuk72	489	36	S1B	S1B	NNP
cord-001859-d62iuk72	489	37	Fig	Fig	NNP
cord-001859-d62iuk72	489	38	)	)	-RRB-
cord-001859-d62iuk72	489	39	.	.	.
cord-001859-d62iuk72	490	1	Therefore	therefore	RB
cord-001859-d62iuk72	490	2	,	,	,
cord-001859-d62iuk72	490	3	our	-PRON-	PRP$
cord-001859-d62iuk72	490	4	results	result	NNS
cord-001859-d62iuk72	490	5	strongly	strongly	RB
cord-001859-d62iuk72	490	6	suggest	suggest	VBP
cord-001859-d62iuk72	490	7	that	that	IN
cord-001859-d62iuk72	490	8	these	these	DT
cord-001859-d62iuk72	490	9	chaperones	chaperone	NNS
cord-001859-d62iuk72	490	10	may	may	MD
cord-001859-d62iuk72	490	11	also	also	RB
cord-001859-d62iuk72	490	12	aid	aid	VB
cord-001859-d62iuk72	490	13	replication	replication	NN
cord-001859-d62iuk72	490	14	of	of	IN
cord-001859-d62iuk72	490	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	490	16	genomes	genome	NNS
cord-001859-d62iuk72	490	17	during	during	IN
cord-001859-d62iuk72	490	18	lytic	lytic	JJ
cord-001859-d62iuk72	490	19	replication	replication	NN
cord-001859-d62iuk72	490	20	.	.	.
cord-001859-d62iuk72	491	1	We	-PRON-	PRP
cord-001859-d62iuk72	491	2	therefore	therefore	RB
cord-001859-d62iuk72	491	3	further	further	RB
cord-001859-d62iuk72	491	4	suggest	suggest	VBP
cord-001859-d62iuk72	491	5	that	that	IN
cord-001859-d62iuk72	491	6	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	491	7	isoforms	isoform	NNS
cord-001859-d62iuk72	491	8	may	may	MD
cord-001859-d62iuk72	491	9	have	have	VB
cord-001859-d62iuk72	491	10	an	an	DT
cord-001859-d62iuk72	491	11	important	important	JJ
cord-001859-d62iuk72	491	12	role	role	NN
cord-001859-d62iuk72	491	13	in	in	IN
cord-001859-d62iuk72	491	14	the	the	DT
cord-001859-d62iuk72	491	15	assembly	assembly	NN
cord-001859-d62iuk72	491	16	and	and	CC
cord-001859-d62iuk72	491	17	activation	activation	NN
cord-001859-d62iuk72	491	18	of	of	IN
cord-001859-d62iuk72	491	19	pre	pre	JJ
cord-001859-d62iuk72	491	20	-	-	JJ
cord-001859-d62iuk72	491	21	initiation	initiation	JJ
cord-001859-d62iuk72	491	22	complexes	complex	NNS
cord-001859-d62iuk72	491	23	on	on	IN
cord-001859-d62iuk72	491	24	the	the	DT
cord-001859-d62iuk72	491	25	origin	origin	NN
cord-001859-d62iuk72	491	26	of	of	IN
cord-001859-d62iuk72	491	27	DNA	dna	NN
cord-001859-d62iuk72	491	28	replication	replication	NN
cord-001859-d62iuk72	491	29	.	.	.
cord-001859-d62iuk72	492	1	This	this	DT
cord-001859-d62iuk72	492	2	is	be	VBZ
cord-001859-d62iuk72	492	3	supported	support	VBN
cord-001859-d62iuk72	492	4	by	by	IN
cord-001859-d62iuk72	492	5	observations	observation	NNS
cord-001859-d62iuk72	492	6	in	in	IN
cord-001859-d62iuk72	492	7	prokaryotes	prokaryote	NNS
cord-001859-d62iuk72	492	8	,	,	,
cord-001859-d62iuk72	492	9	such	such	JJ
cord-001859-d62iuk72	492	10	as	as	IN
cord-001859-d62iuk72	492	11	in	in	IN
cord-001859-d62iuk72	492	12	plasmid	plasmid	NN
cord-001859-d62iuk72	492	13	P1	P1	NNP
cord-001859-d62iuk72	492	14	[	[	-LRB-
cord-001859-d62iuk72	492	15	78	78	CD
cord-001859-d62iuk72	492	16	,	,	,
cord-001859-d62iuk72	492	17	79	79	CD
cord-001859-d62iuk72	492	18	]	]	-RRB-
cord-001859-d62iuk72	492	19	,	,	,
cord-001859-d62iuk72	492	20	and	and	CC
cord-001859-d62iuk72	492	21	eukaryotes	eukaryote	NNS
cord-001859-d62iuk72	492	22	,	,	,
cord-001859-d62iuk72	492	23	such	such	JJ
cord-001859-d62iuk72	492	24	as	as	IN
cord-001859-d62iuk72	492	25	Saccharomyces	saccharomyce	NNS
cord-001859-d62iuk72	492	26	cerevisiae	cerevisiae	NNS
cord-001859-d62iuk72	492	27	[	[	-LRB-
cord-001859-d62iuk72	492	28	80	80	CD
cord-001859-d62iuk72	492	29	]	]	-RRB-
cord-001859-d62iuk72	492	30	,	,	.
cord-001859-d62iuk72	493	1	human	human	JJ
cord-001859-d62iuk72	493	2	papillomavirus-11	papillomavirus-11	XX
cord-001859-d62iuk72	493	3	[	[	-LRB-
cord-001859-d62iuk72	493	4	81	81	CD
cord-001859-d62iuk72	493	5	,	,	,
cord-001859-d62iuk72	493	6	82	82	CD
cord-001859-d62iuk72	493	7	]	]	-RRB-
cord-001859-d62iuk72	493	8	,	,	,
cord-001859-d62iuk72	493	9	HSV-1	HSV-1	NNS
cord-001859-d62iuk72	493	10	[	[	-LRB-
cord-001859-d62iuk72	493	11	83	83	CD
cord-001859-d62iuk72	493	12	]	]	-RRB-
cord-001859-d62iuk72	493	13	and	and	CC
cord-001859-d62iuk72	493	14	bacteriophage	bacteriophage	NN
cord-001859-d62iuk72	493	15	λ	λ	NNP
cord-001859-d62iuk72	493	16	[	[	-LRB-
cord-001859-d62iuk72	493	17	84	84	CD
cord-001859-d62iuk72	493	18	,	,	,
cord-001859-d62iuk72	493	19	85	85	CD
cord-001859-d62iuk72	493	20	]	]	-RRB-
cord-001859-d62iuk72	493	21	.	.	.
cord-001859-d62iuk72	494	1	Interestingly	interestingly	RB
cord-001859-d62iuk72	494	2	,	,	,
cord-001859-d62iuk72	494	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	494	4	isoforms	isoform	NNS
cord-001859-d62iuk72	494	5	have	have	VBP
cord-001859-d62iuk72	494	6	also	also	RB
cord-001859-d62iuk72	494	7	been	be	VBN
cord-001859-d62iuk72	494	8	identified	identify	VBN
cord-001859-d62iuk72	494	9	in	in	IN
cord-001859-d62iuk72	494	10	the	the	DT
cord-001859-d62iuk72	494	11	KSHV	KSHV	NNP
cord-001859-d62iuk72	494	12	virion	virion	NN
cord-001859-d62iuk72	494	13	[	[	-LRB-
cord-001859-d62iuk72	494	14	86	86	CD
cord-001859-d62iuk72	494	15	,	,	,
cord-001859-d62iuk72	494	16	87	87	CD
cord-001859-d62iuk72	494	17	]	]	-RRB-
cord-001859-d62iuk72	494	18	and	and	CC
cord-001859-d62iuk72	494	19	therefore	therefore	RB
cord-001859-d62iuk72	494	20	an	an	DT
cord-001859-d62iuk72	494	21	additional	additional	JJ
cord-001859-d62iuk72	494	22	role	role	NN
cord-001859-d62iuk72	494	23	of	of	IN
cord-001859-d62iuk72	494	24	these	these	DT
cord-001859-d62iuk72	494	25	chaperones	chaperone	NNS
cord-001859-d62iuk72	494	26	in	in	IN
cord-001859-d62iuk72	494	27	KSHV	KSHV	NNP
cord-001859-d62iuk72	494	28	capsid	capsid	NN
cord-001859-d62iuk72	494	29	assembly	assembly	NN
cord-001859-d62iuk72	494	30	may	may	MD
cord-001859-d62iuk72	494	31	also	also	RB
cord-001859-d62iuk72	494	32	be	be	VB
cord-001859-d62iuk72	494	33	possible	possible	JJ
cord-001859-d62iuk72	494	34	.	.	.
cord-001859-d62iuk72	495	1	Cancer	cancer	NN
cord-001859-d62iuk72	495	2	cells	cell	NNS
cord-001859-d62iuk72	495	3	greatly	greatly	RB
cord-001859-d62iuk72	495	4	rely	rely	VBP
cord-001859-d62iuk72	495	5	on	on	IN
cord-001859-d62iuk72	495	6	members	member	NNS
cord-001859-d62iuk72	495	7	of	of	IN
cord-001859-d62iuk72	495	8	the	the	DT
cord-001859-d62iuk72	495	9	HSP70	HSP70	NNP
cord-001859-d62iuk72	495	10	and	and	CC
cord-001859-d62iuk72	495	11	HSP90	hsp90	JJ
cord-001859-d62iuk72	495	12	chaperone	chaperone	NN
cord-001859-d62iuk72	495	13	families	family	NNS
cord-001859-d62iuk72	495	14	for	for	IN
cord-001859-d62iuk72	495	15	their	-PRON-	PRP$
cord-001859-d62iuk72	495	16	growth	growth	NN
cord-001859-d62iuk72	495	17	and	and	CC
cord-001859-d62iuk72	495	18	survival	survival	NN
cord-001859-d62iuk72	495	19	[	[	-LRB-
cord-001859-d62iuk72	495	20	5	5	CD
cord-001859-d62iuk72	495	21	,	,	,
cord-001859-d62iuk72	495	22	88	88	CD
cord-001859-d62iuk72	495	23	]	]	-RRB-
cord-001859-d62iuk72	495	24	,	,	,
cord-001859-d62iuk72	495	25	consequently	consequently	RB
cord-001859-d62iuk72	495	26	,	,	,
cord-001859-d62iuk72	495	27	significant	significant	JJ
cord-001859-d62iuk72	495	28	efforts	effort	NNS
cord-001859-d62iuk72	495	29	have	have	VBP
cord-001859-d62iuk72	495	30	been	be	VBN
cord-001859-d62iuk72	495	31	invested	invest	VBN
cord-001859-d62iuk72	495	32	to	to	TO
cord-001859-d62iuk72	495	33	design	design	VB
cord-001859-d62iuk72	495	34	small	small	JJ
cord-001859-d62iuk72	495	35	molecule	molecule	NN
cord-001859-d62iuk72	495	36	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	495	37	specific	specific	JJ
cord-001859-d62iuk72	495	38	for	for	IN
cord-001859-d62iuk72	495	39	these	these	DT
cord-001859-d62iuk72	495	40	ATPases	atpase	NNS
cord-001859-d62iuk72	495	41	as	as	IN
cord-001859-d62iuk72	495	42	novel	novel	JJ
cord-001859-d62iuk72	495	43	anticancer	anticancer	JJ
cord-001859-d62iuk72	495	44	therapeutics	therapeutic	NNS
cord-001859-d62iuk72	495	45	.	.	.
cord-001859-d62iuk72	496	1	This	this	DT
cord-001859-d62iuk72	496	2	has	have	VBZ
cord-001859-d62iuk72	496	3	been	be	VBN
cord-001859-d62iuk72	496	4	successfully	successfully	RB
cord-001859-d62iuk72	496	5	achieved	achieve	VBN
cord-001859-d62iuk72	496	6	for	for	IN
cord-001859-d62iuk72	496	7	the	the	DT
cord-001859-d62iuk72	496	8	HSP90	HSP90	NNP
cord-001859-d62iuk72	496	9	family	family	NN
cord-001859-d62iuk72	496	10	with	with	IN
cord-001859-d62iuk72	496	11	several	several	JJ
cord-001859-d62iuk72	496	12	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	496	13	undergoing	undergo	VBG
cord-001859-d62iuk72	496	14	phase	phase	NN
cord-001859-d62iuk72	496	15	III	iii	CD
cord-001859-d62iuk72	496	16	clinical	clinical	JJ
cord-001859-d62iuk72	496	17	trials	trial	NNS
cord-001859-d62iuk72	496	18	[	[	-LRB-
cord-001859-d62iuk72	496	19	14	14	CD
cord-001859-d62iuk72	496	20	]	]	-RRB-
cord-001859-d62iuk72	496	21	,	,	,
cord-001859-d62iuk72	496	22	although	although	IN
cord-001859-d62iuk72	496	23	the	the	DT
cord-001859-d62iuk72	496	24	clinical	clinical	JJ
cord-001859-d62iuk72	496	25	efficacy	efficacy	NN
cord-001859-d62iuk72	496	26	of	of	IN
cord-001859-d62iuk72	496	27	these	these	DT
cord-001859-d62iuk72	496	28	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	496	29	has	have	VBZ
cord-001859-d62iuk72	496	30	been	be	VBN
cord-001859-d62iuk72	496	31	somewhat	somewhat	RB
cord-001859-d62iuk72	496	32	limited	limited	JJ
cord-001859-d62iuk72	496	33	because	because	IN
cord-001859-d62iuk72	496	34	of	of	IN
cord-001859-d62iuk72	496	35	the	the	DT
cord-001859-d62iuk72	496	36	inevitably	inevitably	RB
cord-001859-d62iuk72	496	37	upregulation	upregulation	NN
cord-001859-d62iuk72	496	38	of	of	IN
cord-001859-d62iuk72	496	39	iHsp70	ihsp70	NN
cord-001859-d62iuk72	496	40	,	,	,
cord-001859-d62iuk72	496	41	when	when	WRB
cord-001859-d62iuk72	496	42	inhibiting	inhibit	VBG
cord-001859-d62iuk72	496	43	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	496	44	[	[	-LRB-
cord-001859-d62iuk72	496	45	56	56	CD
cord-001859-d62iuk72	496	46	,	,	,
cord-001859-d62iuk72	496	47	57	57	CD
cord-001859-d62iuk72	496	48	]	]	-RRB-
cord-001859-d62iuk72	496	49	.	.	.
cord-001859-d62iuk72	497	1	The	the	DT
cord-001859-d62iuk72	497	2	development	development	NN
cord-001859-d62iuk72	497	3	of	of	IN
cord-001859-d62iuk72	497	4	HSP70	HSP70	NNP
cord-001859-d62iuk72	497	5	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	497	6	has	have	VBZ
cord-001859-d62iuk72	497	7	substantially	substantially	RB
cord-001859-d62iuk72	497	8	lagged	lag	VBN
cord-001859-d62iuk72	497	9	behind	behind	IN
cord-001859-d62iuk72	497	10	that	that	DT
cord-001859-d62iuk72	497	11	of	of	IN
cord-001859-d62iuk72	497	12	HSP90	HSP90	NNP
cord-001859-d62iuk72	497	13	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	497	14	due	due	JJ
cord-001859-d62iuk72	497	15	to	to	IN
cord-001859-d62iuk72	497	16	lack	lack	NN
cord-001859-d62iuk72	497	17	of	of	IN
cord-001859-d62iuk72	497	18	natural	natural	JJ
cord-001859-d62iuk72	497	19	product	product	NN
cord-001859-d62iuk72	497	20	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	497	21	specific	specific	JJ
cord-001859-d62iuk72	497	22	for	for	IN
cord-001859-d62iuk72	497	23	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	497	24	isoforms	isoform	NNS
cord-001859-d62iuk72	497	25	,	,	,
cord-001859-d62iuk72	497	26	due	due	IN
cord-001859-d62iuk72	497	27	to	to	IN
cord-001859-d62iuk72	497	28	the	the	DT
cord-001859-d62iuk72	497	29	highly	highly	RB
cord-001859-d62iuk72	497	30	polar	polar	JJ
cord-001859-d62iuk72	497	31	nature	nature	NN
cord-001859-d62iuk72	497	32	of	of	IN
cord-001859-d62iuk72	497	33	the	the	DT
cord-001859-d62iuk72	497	34	Hsp70/	Hsp70/	NNP
cord-001859-d62iuk72	497	35	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	497	36	ATP	ATP	NNP
cord-001859-d62iuk72	497	37	binding	binding	NN
cord-001859-d62iuk72	497	38	site	site	NN
cord-001859-d62iuk72	497	39	and	and	CC
cord-001859-d62iuk72	497	40	the	the	DT
cord-001859-d62iuk72	497	41	high	high	JJ
cord-001859-d62iuk72	497	42	affinity	affinity	NN
cord-001859-d62iuk72	497	43	for	for	IN
cord-001859-d62iuk72	497	44	ATP	ATP	NNP
cord-001859-d62iuk72	497	45	displayed	display	VBN
cord-001859-d62iuk72	497	46	by	by	IN
cord-001859-d62iuk72	497	47	these	these	DT
cord-001859-d62iuk72	497	48	ATPases	atpase	NNS
cord-001859-d62iuk72	497	49	[	[	-LRB-
cord-001859-d62iuk72	497	50	12	12	CD
cord-001859-d62iuk72	497	51	]	]	-RRB-
cord-001859-d62iuk72	497	52	.	.	.
cord-001859-d62iuk72	498	1	Nevertheless	nevertheless	RB
cord-001859-d62iuk72	498	2	,	,	,
cord-001859-d62iuk72	498	3	in	in	IN
cord-001859-d62iuk72	498	4	recent	recent	JJ
cord-001859-d62iuk72	498	5	years	year	NNS
cord-001859-d62iuk72	498	6	several	several	JJ
cord-001859-d62iuk72	498	7	HSP70	HSP70	NNP
cord-001859-d62iuk72	498	8	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	498	9	have	have	VBP
cord-001859-d62iuk72	498	10	been	be	VBN
cord-001859-d62iuk72	498	11	designed	design	VBN
cord-001859-d62iuk72	498	12	and	and	CC
cord-001859-d62iuk72	498	13	tested	test	VBN
cord-001859-d62iuk72	498	14	in	in	IN
cord-001859-d62iuk72	498	15	pre	pre	JJ
cord-001859-d62iuk72	498	16	-	-	JJ
cord-001859-d62iuk72	498	17	clinical	clinical	JJ
cord-001859-d62iuk72	498	18	or	or	CC
cord-001859-d62iuk72	498	19	clinical	clinical	JJ
cord-001859-d62iuk72	498	20	trials	trial	NNS
cord-001859-d62iuk72	498	21	[	[	-LRB-
cord-001859-d62iuk72	498	22	88	88	CD
cord-001859-d62iuk72	498	23	]	]	-RRB-
cord-001859-d62iuk72	498	24	.	.	.
cord-001859-d62iuk72	499	1	However	however	RB
cord-001859-d62iuk72	499	2	,	,	,
cord-001859-d62iuk72	499	3	a	a	DT
cord-001859-d62iuk72	499	4	major	major	JJ
cord-001859-d62iuk72	499	5	challenge	challenge	NN
cord-001859-d62iuk72	499	6	remains	remain	VBZ
cord-001859-d62iuk72	499	7	in	in	IN
cord-001859-d62iuk72	499	8	finding	find	VBG
cord-001859-d62iuk72	499	9	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	499	10	which	which	WDT
cord-001859-d62iuk72	499	11	can	can	MD
cord-001859-d62iuk72	499	12	specifically	specifically	RB
cord-001859-d62iuk72	499	13	discriminate	discriminate	VB
cord-001859-d62iuk72	499	14	between	between	IN
cord-001859-d62iuk72	499	15	iHsp70	ihsp70	XX
cord-001859-d62iuk72	499	16	and	and	CC
cord-001859-d62iuk72	499	17	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	499	18	.	.	.
cord-001859-d62iuk72	500	1	To	to	IN
cord-001859-d62iuk72	500	2	date	date	NN
cord-001859-d62iuk72	500	3	,	,	,
cord-001859-d62iuk72	500	4	only	only	RB
cord-001859-d62iuk72	500	5	peptide	peptide	JJ
cord-001859-d62iuk72	500	6	aptamers	aptamer	NNS
cord-001859-d62iuk72	500	7	targeting	target	VBG
cord-001859-d62iuk72	501	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	501	2	are	be	VBP
cord-001859-d62iuk72	501	3	selective	selective	JJ
cord-001859-d62iuk72	501	4	for	for	IN
cord-001859-d62iuk72	501	5	a	a	DT
cord-001859-d62iuk72	501	6	specific	specific	JJ
cord-001859-d62iuk72	501	7	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	501	8	isoform	isoform	NN
cord-001859-d62iuk72	501	9	[	[	-LRB-
cord-001859-d62iuk72	501	10	89	89	CD
cord-001859-d62iuk72	501	11	]	]	-RRB-
cord-001859-d62iuk72	501	12	and	and	CC
cord-001859-d62iuk72	501	13	also	also	RB
cord-001859-d62iuk72	501	14	recently	recently	RB
cord-001859-d62iuk72	501	15	,	,	,
cord-001859-d62iuk72	501	16	methyl	methyl	NN
cord-001859-d62iuk72	501	17	blue	blue	NN
cord-001859-d62iuk72	501	18	was	be	VBD
cord-001859-d62iuk72	501	19	reported	report	VBN
cord-001859-d62iuk72	501	20	to	to	TO
cord-001859-d62iuk72	501	21	specifically	specifically	RB
cord-001859-d62iuk72	501	22	inhibit	inhibit	VB
cord-001859-d62iuk72	501	23	iHsp70	ihsp70	XX
cord-001859-d62iuk72	501	24	by	by	IN
cord-001859-d62iuk72	501	25	oxidizing	oxidize	VBG
cord-001859-d62iuk72	501	26	a	a	DT
cord-001859-d62iuk72	501	27	cysteine	cysteine	NN
cord-001859-d62iuk72	501	28	in	in	IN
cord-001859-d62iuk72	501	29	its	-PRON-	PRP$
cord-001859-d62iuk72	501	30	ATPase	ATPase	NNP
cord-001859-d62iuk72	501	31	domain	domain	NN
cord-001859-d62iuk72	501	32	,	,	,
cord-001859-d62iuk72	501	33	the	the	DT
cord-001859-d62iuk72	501	34	same	same	JJ
cord-001859-d62iuk72	501	35	residue	residue	NN
cord-001859-d62iuk72	501	36	is	be	VBZ
cord-001859-d62iuk72	501	37	absent	absent	JJ
cord-001859-d62iuk72	501	38	in	in	IN
cord-001859-d62iuk72	501	39	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	501	40	allowing	allow	VBG
cord-001859-d62iuk72	501	41	differential	differential	NN
cord-001859-d62iuk72	501	42	targeting	targeting	NN
cord-001859-d62iuk72	501	43	of	of	IN
cord-001859-d62iuk72	501	44	the	the	DT
cord-001859-d62iuk72	501	45	isoforms	isoform	NNS
cord-001859-d62iuk72	501	46	[	[	-LRB-
cord-001859-d62iuk72	501	47	90	90	CD
cord-001859-d62iuk72	501	48	]	]	-RRB-
cord-001859-d62iuk72	501	49	.	.	.
cord-001859-d62iuk72	502	1	Because	because	IN
cord-001859-d62iuk72	502	2	both	both	DT
cord-001859-d62iuk72	502	3	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	502	4	and	and	CC
cord-001859-d62iuk72	502	5	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	502	6	were	be	VBD
cord-001859-d62iuk72	502	7	specifically	specifically	RB
cord-001859-d62iuk72	502	8	redistributed	redistribute	VBN
cord-001859-d62iuk72	502	9	to	to	IN
cord-001859-d62iuk72	502	10	KSHV	KSHV	NNP
cord-001859-d62iuk72	502	11	RTCs	rtc	NNS
cord-001859-d62iuk72	502	12	during	during	IN
cord-001859-d62iuk72	502	13	lytic	lytic	JJ
cord-001859-d62iuk72	502	14	replication	replication	NN
cord-001859-d62iuk72	502	15	,	,	,
cord-001859-d62iuk72	502	16	we	-PRON-	PRP
cord-001859-d62iuk72	502	17	made	make	VBD
cord-001859-d62iuk72	502	18	use	use	NN
cord-001859-d62iuk72	502	19	of	of	IN
cord-001859-d62iuk72	502	20	a	a	DT
cord-001859-d62iuk72	502	21	recently	recently	RB
cord-001859-d62iuk72	502	22	developed	develop	VBN
cord-001859-d62iuk72	502	23	small	small	JJ
cord-001859-d62iuk72	502	24	molecule	molecule	NN
cord-001859-d62iuk72	502	25	inhibitor	inhibitor	NN
cord-001859-d62iuk72	502	26	,	,	,
cord-001859-d62iuk72	502	27	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	502	28	,	,	,
cord-001859-d62iuk72	502	29	which	which	WDT
cord-001859-d62iuk72	502	30	targets	target	VBZ
cord-001859-d62iuk72	502	31	the	the	DT
cord-001859-d62iuk72	502	32	ATPase	ATPase	NNP
cord-001859-d62iuk72	502	33	pocket	pocket	NN
cord-001859-d62iuk72	502	34	of	of	IN
cord-001859-d62iuk72	502	35	the	the	DT
cord-001859-d62iuk72	502	36	main	main	JJ
cord-001859-d62iuk72	502	37	three	three	CD
cord-001859-d62iuk72	502	38	human	human	NN
cord-001859-d62iuk72	502	39	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	502	40	isoforms	isoform	NNS
cord-001859-d62iuk72	502	41	.	.	.
cord-001859-d62iuk72	503	1	This	this	DT
cord-001859-d62iuk72	503	2	inhibitor	inhibitor	NN
cord-001859-d62iuk72	503	3	used	use	VBN
cord-001859-d62iuk72	503	4	at	at	IN
cord-001859-d62iuk72	503	5	non	non	JJ
cord-001859-d62iuk72	503	6	-	-	JJ
cord-001859-d62iuk72	503	7	cytotoxic	cytotoxic	JJ
cord-001859-d62iuk72	503	8	concentrations	concentration	NNS
cord-001859-d62iuk72	503	9	was	be	VBD
cord-001859-d62iuk72	503	10	able	able	JJ
cord-001859-d62iuk72	503	11	to	to	TO
cord-001859-d62iuk72	503	12	effectively	effectively	RB
cord-001859-d62iuk72	503	13	abrogate	abrogate	VB
cord-001859-d62iuk72	503	14	early	early	JJ
cord-001859-d62iuk72	503	15	and	and	CC
cord-001859-d62iuk72	503	16	late	late	JJ
cord-001859-d62iuk72	503	17	KSHV	KSHV	NNP
cord-001859-d62iuk72	503	18	transcription	transcription	NN
cord-001859-d62iuk72	503	19	together	together	RB
cord-001859-d62iuk72	503	20	with	with	IN
cord-001859-d62iuk72	503	21	viral	viral	JJ
cord-001859-d62iuk72	503	22	protein	protein	NN
cord-001859-d62iuk72	503	23	production	production	NN
cord-001859-d62iuk72	503	24	,	,	,
cord-001859-d62iuk72	503	25	viral	viral	JJ
cord-001859-d62iuk72	503	26	DNA	dna	NN
cord-001859-d62iuk72	503	27	replication	replication	NN
cord-001859-d62iuk72	503	28	and	and	CC
cord-001859-d62iuk72	503	29	viral	viral	JJ
cord-001859-d62iuk72	503	30	progeny	progeny	NN
cord-001859-d62iuk72	503	31	.	.	.
cord-001859-d62iuk72	504	1	Therefore	therefore	RB
cord-001859-d62iuk72	504	2	,	,	,
cord-001859-d62iuk72	504	3	our	-PRON-	PRP$
cord-001859-d62iuk72	504	4	study	study	NN
cord-001859-d62iuk72	504	5	highlights	highlight	VBZ
cord-001859-d62iuk72	504	6	the	the	DT
cord-001859-d62iuk72	504	7	potential	potential	NN
cord-001859-d62iuk72	504	8	of	of	IN
cord-001859-d62iuk72	504	9	VER-155008	ver-155008	JJ
cord-001859-d62iuk72	504	10	or	or	CC
cord-001859-d62iuk72	504	11	other	other	JJ
cord-001859-d62iuk72	504	12	novel	novel	NN
cord-001859-d62iuk72	504	13	HSP70	HSP70	NNP
cord-001859-d62iuk72	504	14	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	504	15	to	to	TO
cord-001859-d62iuk72	504	16	prevent	prevent	VB
cord-001859-d62iuk72	504	17	KSHV	KSHV	NNP
cord-001859-d62iuk72	504	18	lytic	lytic	JJ
cord-001859-d62iuk72	504	19	replication	replication	NN
cord-001859-d62iuk72	504	20	in	in	IN
cord-001859-d62iuk72	504	21	KSHV	KSHV	NNP
cord-001859-d62iuk72	504	22	-	-	HYPH
cord-001859-d62iuk72	504	23	associated	associate	VBN
cord-001859-d62iuk72	504	24	tumours	tumour	NNS
cord-001859-d62iuk72	504	25	.	.	.
cord-001859-d62iuk72	505	1	One	one	PRP
cord-001859-d62iuk72	505	2	could	could	MD
cord-001859-d62iuk72	505	3	expect	expect	VB
cord-001859-d62iuk72	505	4	that	that	IN
cord-001859-d62iuk72	505	5	HSP70	HSP70	NNP
cord-001859-d62iuk72	505	6	inhibition	inhibition	NN
cord-001859-d62iuk72	505	7	would	would	MD
cord-001859-d62iuk72	505	8	be	be	VB
cord-001859-d62iuk72	505	9	directly	directly	RB
cord-001859-d62iuk72	505	10	detrimental	detrimental	JJ
cord-001859-d62iuk72	505	11	not	not	RB
cord-001859-d62iuk72	505	12	only	only	RB
cord-001859-d62iuk72	505	13	to	to	IN
cord-001859-d62iuk72	505	14	cancer	cancer	NN
cord-001859-d62iuk72	505	15	cell	cell	NN
cord-001859-d62iuk72	505	16	survival	survival	NN
cord-001859-d62iuk72	505	17	but	but	CC
cord-001859-d62iuk72	505	18	also	also	RB
cord-001859-d62iuk72	505	19	the	the	DT
cord-001859-d62iuk72	505	20	virus	virus	NN
cord-001859-d62iuk72	505	21	-	-	HYPH
cord-001859-d62iuk72	505	22	specific	specific	JJ
cord-001859-d62iuk72	505	23	functions	function	NNS
cord-001859-d62iuk72	505	24	that	that	WDT
cord-001859-d62iuk72	505	25	are	be	VBP
cord-001859-d62iuk72	505	26	dependent	dependent	JJ
cord-001859-d62iuk72	505	27	on	on	IN
cord-001859-d62iuk72	505	28	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	505	29	isoforms	isoform	NNS
cord-001859-d62iuk72	505	30	.	.	.
cord-001859-d62iuk72	506	1	These	these	DT
cord-001859-d62iuk72	506	2	results	result	NNS
cord-001859-d62iuk72	506	3	may	may	MD
cord-001859-d62iuk72	506	4	have	have	VB
cord-001859-d62iuk72	506	5	exciting	exciting	JJ
cord-001859-d62iuk72	506	6	implications	implication	NNS
cord-001859-d62iuk72	506	7	in	in	IN
cord-001859-d62iuk72	506	8	combination	combination	NN
cord-001859-d62iuk72	506	9	with	with	IN
cord-001859-d62iuk72	506	10	the	the	DT
cord-001859-d62iuk72	506	11	recently	recently	RB
cord-001859-d62iuk72	506	12	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	506	13	efficacy	efficacy	NN
cord-001859-d62iuk72	506	14	of	of	IN
cord-001859-d62iuk72	506	15	ATP	ATP	NNP
cord-001859-d62iuk72	506	16	-	-	HYPH
cord-001859-d62iuk72	506	17	competitive	competitive	JJ
cord-001859-d62iuk72	506	18	HSP90	HSP90	NNP
cord-001859-d62iuk72	506	19	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	506	20	in	in	IN
cord-001859-d62iuk72	506	21	blocking	block	VBG
cord-001859-d62iuk72	506	22	KSHV	KSHV	NNP
cord-001859-d62iuk72	506	23	latent	latent	JJ
cord-001859-d62iuk72	506	24	cycle	cycle	NN
cord-001859-d62iuk72	506	25	in	in	IN
cord-001859-d62iuk72	506	26	vitro	vitro	FW
cord-001859-d62iuk72	506	27	and	and	CC
cord-001859-d62iuk72	506	28	in	in	IN
cord-001859-d62iuk72	506	29	a	a	DT
cord-001859-d62iuk72	506	30	xenograft	xenograft	NN
cord-001859-d62iuk72	506	31	KSHV	KSHV	NNP
cord-001859-d62iuk72	506	32	tumour	tumour	NN
cord-001859-d62iuk72	506	33	model	model	NN
cord-001859-d62iuk72	506	34	[	[	-LRB-
cord-001859-d62iuk72	506	35	41	41	CD
cord-001859-d62iuk72	506	36	]	]	-RRB-
cord-001859-d62iuk72	506	37	.	.	.
cord-001859-d62iuk72	507	1	It	-PRON-	PRP
cord-001859-d62iuk72	507	2	may	may	MD
cord-001859-d62iuk72	507	3	be	be	VB
cord-001859-d62iuk72	507	4	the	the	DT
cord-001859-d62iuk72	507	5	case	case	NN
cord-001859-d62iuk72	507	6	that	that	IN
cord-001859-d62iuk72	507	7	combining	combine	VBG
cord-001859-d62iuk72	507	8	HSP70	HSP70	NNP
cord-001859-d62iuk72	507	9	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	507	10	with	with	IN
cord-001859-d62iuk72	507	11	HSP90	HSP90	NNP
cord-001859-d62iuk72	507	12	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	507	13	may	may	MD
cord-001859-d62iuk72	507	14	lead	lead	VB
cord-001859-d62iuk72	507	15	to	to	IN
cord-001859-d62iuk72	507	16	enhanced	enhanced	JJ
cord-001859-d62iuk72	507	17	efficacy	efficacy	NN
cord-001859-d62iuk72	507	18	in	in	IN
cord-001859-d62iuk72	507	19	eradicating	eradicate	VBG
cord-001859-d62iuk72	507	20	latent	latent	JJ
cord-001859-d62iuk72	507	21	KSHV	KSHV	NNP
cord-001859-d62iuk72	507	22	reservoirs	reservoir	NNS
cord-001859-d62iuk72	507	23	.	.	.
cord-001859-d62iuk72	508	1	Excitingly	excitingly	RB
cord-001859-d62iuk72	508	2	,	,	,
cord-001859-d62iuk72	508	3	in	in	IN
cord-001859-d62iuk72	508	4	our	-PRON-	PRP$
cord-001859-d62iuk72	508	5	cell	cell	NN
cord-001859-d62iuk72	508	6	culture	culture	NN
cord-001859-d62iuk72	508	7	models	model	NNS
cord-001859-d62iuk72	508	8	VER-155008	ver-155008	NN
cord-001859-d62iuk72	508	9	abrogated	abrogate	VBD
cord-001859-d62iuk72	508	10	lytic	lytic	JJ
cord-001859-d62iuk72	508	11	replication	replication	NN
cord-001859-d62iuk72	508	12	without	without	IN
cord-001859-d62iuk72	508	13	severely	severely	RB
cord-001859-d62iuk72	508	14	affecting	affect	VBG
cord-001859-d62iuk72	508	15	cell	cell	NN
cord-001859-d62iuk72	508	16	viability	viability	NN
cord-001859-d62iuk72	508	17	or	or	CC
cord-001859-d62iuk72	508	18	triggering	trigger	VBG
cord-001859-d62iuk72	508	19	apoptosis	apoptosis	NN
cord-001859-d62iuk72	508	20	.	.	.
cord-001859-d62iuk72	509	1	It	-PRON-	PRP
cord-001859-d62iuk72	509	2	is	be	VBZ
cord-001859-d62iuk72	509	3	intriguing	intriguing	JJ
cord-001859-d62iuk72	509	4	that	that	IN
cord-001859-d62iuk72	509	5	inhibition	inhibition	NN
cord-001859-d62iuk72	509	6	of	of	IN
cord-001859-d62iuk72	509	7	constitutively	constitutively	RB
cord-001859-d62iuk72	509	8	expressed	express	VBN
cord-001859-d62iuk72	509	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	509	10	chaperone	chaperone	NN
cord-001859-d62iuk72	509	11	did	do	VBD
cord-001859-d62iuk72	509	12	not	not	RB
cord-001859-d62iuk72	509	13	result	result	VB
cord-001859-d62iuk72	509	14	in	in	IN
cord-001859-d62iuk72	509	15	cell	cell	NN
cord-001859-d62iuk72	509	16	death	death	NN
cord-001859-d62iuk72	509	17	.	.	.
cord-001859-d62iuk72	510	1	However	however	RB
cord-001859-d62iuk72	510	2	,	,	,
cord-001859-d62iuk72	510	3	it	-PRON-	PRP
cord-001859-d62iuk72	510	4	is	be	VBZ
cord-001859-d62iuk72	510	5	important	important	JJ
cord-001859-d62iuk72	510	6	to	to	TO
cord-001859-d62iuk72	510	7	highlight	highlight	VB
cord-001859-d62iuk72	510	8	previous	previous	JJ
cord-001859-d62iuk72	510	9	studies	study	NNS
cord-001859-d62iuk72	510	10	carried	carry	VBN
cord-001859-d62iuk72	510	11	out	out	RP
cord-001859-d62iuk72	510	12	on	on	IN
cord-001859-d62iuk72	510	13	the	the	DT
cord-001859-d62iuk72	510	14	susceptibility	susceptibility	NN
cord-001859-d62iuk72	510	15	of	of	IN
cord-001859-d62iuk72	510	16	tumour	tumour	NN
cord-001859-d62iuk72	510	17	cells	cell	NNS
cord-001859-d62iuk72	510	18	versus	versus	IN
cord-001859-d62iuk72	510	19	normal	normal	JJ
cord-001859-d62iuk72	510	20	cells	cell	NNS
cord-001859-d62iuk72	510	21	to	to	IN
cord-001859-d62iuk72	510	22	HSP90	HSP90	NNP
cord-001859-d62iuk72	510	23	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	510	24	.	.	.
cord-001859-d62iuk72	511	1	In	in	IN
cord-001859-d62iuk72	511	2	tumour	tumour	NN
cord-001859-d62iuk72	511	3	cells	cell	NNS
cord-001859-d62iuk72	511	4	,	,	,
cord-001859-d62iuk72	511	5	for	for	IN
cord-001859-d62iuk72	511	6	24	24	CD
cord-001859-d62iuk72	511	7	h	h	NN
cord-001859-d62iuk72	511	8	or	or	CC
cord-001859-d62iuk72	511	9	remained	remain	VBD
cord-001859-d62iuk72	511	10	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	511	11	and	and	CC
cord-001859-d62iuk72	511	12	total	total	JJ
cord-001859-d62iuk72	511	13	RNA	RNA	NNP
cord-001859-d62iuk72	511	14	and	and	CC
cord-001859-d62iuk72	511	15	protein	protein	NN
cord-001859-d62iuk72	511	16	were	be	VBD
cord-001859-d62iuk72	511	17	extracted	extract	VBN
cord-001859-d62iuk72	511	18	from	from	IN
cord-001859-d62iuk72	511	19	the	the	DT
cord-001859-d62iuk72	511	20	same	same	JJ
cord-001859-d62iuk72	511	21	sample	sample	NN
cord-001859-d62iuk72	511	22	.	.	.
cord-001859-d62iuk72	512	1	Efficient	efficient	JJ
cord-001859-d62iuk72	512	2	iHsp70	ihsp70	IN
cord-001859-d62iuk72	512	3	knockdown	knockdown	NN
cord-001859-d62iuk72	512	4	was	be	VBD
cord-001859-d62iuk72	512	5	achieved	achieve	VBN
cord-001859-d62iuk72	512	6	both	both	CC
cord-001859-d62iuk72	512	7	at	at	IN
cord-001859-d62iuk72	512	8	the	the	DT
cord-001859-d62iuk72	512	9	mRNA	mRNA	NNP
cord-001859-d62iuk72	512	10	level	level	NN
cord-001859-d62iuk72	512	11	(	(	-LRB-
cord-001859-d62iuk72	512	12	~75	~75	CD
cord-001859-d62iuk72	512	13	%	%	NN
cord-001859-d62iuk72	512	14	)	)	-RRB-
cord-001859-d62iuk72	512	15	(	(	-LRB-
cord-001859-d62iuk72	512	16	A	a	NN
cord-001859-d62iuk72	512	17	)	)	-RRB-
cord-001859-d62iuk72	512	18	and	and	CC
cord-001859-d62iuk72	512	19	the	the	DT
cord-001859-d62iuk72	512	20	protein	protein	NN
cord-001859-d62iuk72	512	21	level	level	NN
cord-001859-d62iuk72	512	22	(	(	-LRB-
cord-001859-d62iuk72	512	23	B	b	NN
cord-001859-d62iuk72	512	24	)	)	-RRB-
cord-001859-d62iuk72	512	25	.	.	.
cord-001859-d62iuk72	513	1	A	a	DT
cord-001859-d62iuk72	513	2	small	small	JJ
cord-001859-d62iuk72	513	3	decrease	decrease	NN
cord-001859-d62iuk72	513	4	in	in	IN
cord-001859-d62iuk72	513	5	the	the	DT
cord-001859-d62iuk72	513	6	amount	amount	NN
cord-001859-d62iuk72	513	7	of	of	IN
cord-001859-d62iuk72	513	8	gL	gL	NNP
cord-001859-d62iuk72	513	9	and	and	CC
cord-001859-d62iuk72	513	10	PAN	PAN	NNP
cord-001859-d62iuk72	513	11	transcripts	transcript	NNS
cord-001859-d62iuk72	513	12	was	be	VBD
cord-001859-d62iuk72	513	13	observed	observe	VBN
cord-001859-d62iuk72	513	14	in	in	IN
cord-001859-d62iuk72	513	15	iHsp70-depleted	iHsp70-depleted	NNP
cord-001859-d62iuk72	513	16	cells	cell	NNS
cord-001859-d62iuk72	513	17	(	(	-LRB-
cord-001859-d62iuk72	513	18	C	C	NNP
cord-001859-d62iuk72	513	19	)	)	-RRB-
cord-001859-d62iuk72	513	20	.	.	.
cord-001859-d62iuk72	514	1	The	the	DT
cord-001859-d62iuk72	514	2	average	average	NN
cord-001859-d62iuk72	514	3	of	of	IN
cord-001859-d62iuk72	514	4	three	three	CD
cord-001859-d62iuk72	514	5	independent	independent	JJ
cord-001859-d62iuk72	514	6	transfections	transfection	NNS
cord-001859-d62iuk72	514	7	is	be	VBZ
cord-001859-d62iuk72	514	8	shown	show	VBN
cord-001859-d62iuk72	514	9	with	with	IN
cord-001859-d62iuk72	514	10	error	error	NN
cord-001859-d62iuk72	514	11	bars	bar	NNS
cord-001859-d62iuk72	514	12	as	as	IN
cord-001859-d62iuk72	514	13	standard	standard	JJ
cord-001859-d62iuk72	514	14	deviation	deviation	NN
cord-001859-d62iuk72	514	15	.	.	.
cord-001859-d62iuk72	515	1	doi:10.1371	doi:10.1371	NNP
cord-001859-d62iuk72	516	1	/journal.ppat.1005274.g011	/journal.ppat.1005274.g011	.
cord-001859-d62iuk72	516	2	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	516	3	is	be	VBZ
cord-001859-d62iuk72	516	4	present	present	JJ
cord-001859-d62iuk72	516	5	entirely	entirely	RB
cord-001859-d62iuk72	516	6	in	in	IN
cord-001859-d62iuk72	516	7	multi	multi	JJ
cord-001859-d62iuk72	516	8	-	-	JJ
cord-001859-d62iuk72	516	9	chaperone	chaperone	JJ
cord-001859-d62iuk72	516	10	complexes	complex	NNS
cord-001859-d62iuk72	516	11	with	with	IN
cord-001859-d62iuk72	516	12	high	high	JJ
cord-001859-d62iuk72	516	13	ATPase	ATPase	NNP
cord-001859-d62iuk72	516	14	activity	activity	NN
cord-001859-d62iuk72	516	15	;	;	:
cord-001859-d62iuk72	517	1	in	in	IN
cord-001859-d62iuk72	517	2	contrast	contrast	NN
cord-001859-d62iuk72	517	3	,	,	,
cord-001859-d62iuk72	517	4	in	in	IN
cord-001859-d62iuk72	517	5	normal	normal	JJ
cord-001859-d62iuk72	517	6	cells	cell	NNS
cord-001859-d62iuk72	517	7	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	517	8	is	be	VBZ
cord-001859-d62iuk72	517	9	in	in	IN
cord-001859-d62iuk72	517	10	an	an	DT
cord-001859-d62iuk72	517	11	uncomplexed	uncomplexed	JJ
cord-001859-d62iuk72	517	12	conformation	conformation	NN
cord-001859-d62iuk72	517	13	.	.	.
cord-001859-d62iuk72	518	1	These	these	DT
cord-001859-d62iuk72	518	2	two	two	CD
cord-001859-d62iuk72	518	3	distinct	distinct	JJ
cord-001859-d62iuk72	519	1	Hsp90	hsp90	JJ
cord-001859-d62iuk72	519	2	presentations	presentation	NNS
cord-001859-d62iuk72	519	3	result	result	VBP
cord-001859-d62iuk72	519	4	in	in	IN
cord-001859-d62iuk72	519	5	tumour	tumour	NN
cord-001859-d62iuk72	519	6	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	519	7	exhibiting	exhibit	VBG
cord-001859-d62iuk72	519	8	a	a	DT
cord-001859-d62iuk72	519	9	100-fold	100-fold	CD
cord-001859-d62iuk72	519	10	higher	high	JJR
cord-001859-d62iuk72	519	11	binding	bind	VBG
cord-001859-d62iuk72	519	12	affinity	affinity	NN
cord-001859-d62iuk72	519	13	to	to	IN
cord-001859-d62iuk72	519	14	an	an	DT
cord-001859-d62iuk72	519	15	HSP90	hsp90	JJ
cord-001859-d62iuk72	519	16	inhibitor	inhibitor	NN
cord-001859-d62iuk72	519	17	than	than	IN
cord-001859-d62iuk72	519	18	normal	normal	JJ
cord-001859-d62iuk72	519	19	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	519	20	[	[	-LRB-
cord-001859-d62iuk72	519	21	91	91	CD
cord-001859-d62iuk72	519	22	]	]	-RRB-
cord-001859-d62iuk72	519	23	.	.	.
cord-001859-d62iuk72	520	1	Thus	thus	RB
cord-001859-d62iuk72	520	2	,	,	,
cord-001859-d62iuk72	520	3	it	-PRON-	PRP
cord-001859-d62iuk72	520	4	is	be	VBZ
cord-001859-d62iuk72	520	5	tempting	tempt	VBG
cord-001859-d62iuk72	520	6	to	to	TO
cord-001859-d62iuk72	520	7	speculate	speculate	VB
cord-001859-d62iuk72	520	8	that	that	IN
cord-001859-d62iuk72	520	9	the	the	DT
cord-001859-d62iuk72	520	10	multi	multi	JJ
cord-001859-d62iuk72	520	11	-	-	JJ
cord-001859-d62iuk72	520	12	chaperone	chaperone	JJ
cord-001859-d62iuk72	520	13	HSP70	HSP70	NNP
cord-001859-d62iuk72	520	14	foci	focus	NNS
cord-001859-d62iuk72	520	15	that	that	WDT
cord-001859-d62iuk72	520	16	are	be	VBP
cord-001859-d62iuk72	520	17	recruited	recruit	VBN
cord-001859-d62iuk72	520	18	to	to	IN
cord-001859-d62iuk72	520	19	KSHV	KSHV	NNP
cord-001859-d62iuk72	520	20	RTCs	rtc	NNS
cord-001859-d62iuk72	520	21	during	during	IN
cord-001859-d62iuk72	520	22	lytic	lytic	JJ
cord-001859-d62iuk72	520	23	replication	replication	NN
cord-001859-d62iuk72	520	24	(	(	-LRB-
cord-001859-d62iuk72	520	25	Fig	Fig	NNP
cord-001859-d62iuk72	520	26	2	2	CD
cord-001859-d62iuk72	520	27	and	and	CC
cord-001859-d62iuk72	520	28	S1	S1	NNP
cord-001859-d62iuk72	520	29	Fig	Fig	NNP
cord-001859-d62iuk72	520	30	)	)	-RRB-
cord-001859-d62iuk72	520	31	are	be	VBP
cord-001859-d62iuk72	520	32	more	more	RBR
cord-001859-d62iuk72	520	33	sensitive	sensitive	JJ
cord-001859-d62iuk72	520	34	to	to	IN
cord-001859-d62iuk72	520	35	VER-155008	ver-155008	NN
cord-001859-d62iuk72	520	36	than	than	IN
cord-001859-d62iuk72	520	37	the	the	DT
cord-001859-d62iuk72	520	38	chaperones	chaperone	NNS
cord-001859-d62iuk72	520	39	not	not	RB
cord-001859-d62iuk72	520	40	assembled	assemble	VBN
cord-001859-d62iuk72	520	41	in	in	IN
cord-001859-d62iuk72	520	42	VICE	vice	NN
cord-001859-d62iuk72	520	43	domains	domain	NNS
cord-001859-d62iuk72	520	44	which	which	WDT
cord-001859-d62iuk72	520	45	carry	carry	VBP
cord-001859-d62iuk72	520	46	out	out	RP
cord-001859-d62iuk72	520	47	the	the	DT
cord-001859-d62iuk72	520	48	housekeeping	housekeeping	NN
cord-001859-d62iuk72	520	49	functions	function	NNS
cord-001859-d62iuk72	520	50	for	for	IN
cord-001859-d62iuk72	520	51	cell	cell	NN
cord-001859-d62iuk72	520	52	survival	survival	NN
cord-001859-d62iuk72	520	53	.	.	.
cord-001859-d62iuk72	521	1	This	this	DT
cord-001859-d62iuk72	521	2	would	would	MD
cord-001859-d62iuk72	521	3	explain	explain	VB
cord-001859-d62iuk72	521	4	why	why	WRB
cord-001859-d62iuk72	521	5	HSP70	HSP70	NNP
cord-001859-d62iuk72	521	6	inhibition	inhibition	NN
cord-001859-d62iuk72	521	7	had	have	VBD
cord-001859-d62iuk72	521	8	a	a	DT
cord-001859-d62iuk72	521	9	profound	profound	JJ
cord-001859-d62iuk72	521	10	effect	effect	NN
cord-001859-d62iuk72	521	11	on	on	IN
cord-001859-d62iuk72	521	12	KSHV	KSHV	NNP
cord-001859-d62iuk72	521	13	lytic	lytic	JJ
cord-001859-d62iuk72	521	14	replication	replication	NN
cord-001859-d62iuk72	521	15	without	without	IN
cord-001859-d62iuk72	521	16	affecting	affect	VBG
cord-001859-d62iuk72	521	17	cell	cell	NN
cord-001859-d62iuk72	521	18	viability	viability	NN
cord-001859-d62iuk72	521	19	and	and	CC
cord-001859-d62iuk72	521	20	support	support	VB
cord-001859-d62iuk72	521	21	the	the	DT
cord-001859-d62iuk72	521	22	idea	idea	NN
cord-001859-d62iuk72	521	23	that	that	IN
cord-001859-d62iuk72	521	24	isoform	isoform	NN
cord-001859-d62iuk72	521	25	specificity	specificity	NN
cord-001859-d62iuk72	521	26	may	may	MD
cord-001859-d62iuk72	521	27	not	not	RB
cord-001859-d62iuk72	521	28	be	be	VB
cord-001859-d62iuk72	521	29	a	a	DT
cord-001859-d62iuk72	521	30	requirement	requirement	NN
cord-001859-d62iuk72	521	31	for	for	IN
cord-001859-d62iuk72	521	32	treatment	treatment	NN
cord-001859-d62iuk72	521	33	of	of	IN
cord-001859-d62iuk72	521	34	KSHV	KSHV	NNP
cord-001859-d62iuk72	521	35	-	-	HYPH
cord-001859-d62iuk72	521	36	associated	associate	VBN
cord-001859-d62iuk72	521	37	tumours	tumour	NNS
cord-001859-d62iuk72	521	38	.	.	.
cord-001859-d62iuk72	522	1	To	to	TO
cord-001859-d62iuk72	522	2	establish	establish	VB
cord-001859-d62iuk72	522	3	the	the	DT
cord-001859-d62iuk72	522	4	essential	essential	JJ
cord-001859-d62iuk72	522	5	role	role	NN
cord-001859-d62iuk72	522	6	of	of	IN
cord-001859-d62iuk72	522	7	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	522	8	isoforms	isoform	NNS
cord-001859-d62iuk72	522	9	during	during	IN
cord-001859-d62iuk72	522	10	KSHV	KSHV	NNP
cord-001859-d62iuk72	522	11	lytic	lytic	JJ
cord-001859-d62iuk72	522	12	replication	replication	NN
cord-001859-d62iuk72	522	13	,	,	,
cord-001859-d62iuk72	522	14	we	-PRON-	PRP
cord-001859-d62iuk72	522	15	examined	examine	VBD
cord-001859-d62iuk72	522	16	several	several	JJ
cord-001859-d62iuk72	522	17	possible	possible	JJ
cord-001859-d62iuk72	522	18	functions	function	NNS
cord-001859-d62iuk72	522	19	.	.	.
cord-001859-d62iuk72	523	1	It	-PRON-	PRP
cord-001859-d62iuk72	523	2	could	could	MD
cord-001859-d62iuk72	523	3	be	be	VB
cord-001859-d62iuk72	523	4	hypothesised	hypothesise	VBN
cord-001859-d62iuk72	523	5	that	that	IN
cord-001859-d62iuk72	523	6	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	523	7	isoforms	isoform	NNS
cord-001859-d62iuk72	523	8	could	could	MD
cord-001859-d62iuk72	523	9	be	be	VB
cord-001859-d62iuk72	523	10	implicated	implicate	VBN
cord-001859-d62iuk72	523	11	in	in	IN
cord-001859-d62iuk72	523	12	1	1	CD
cord-001859-d62iuk72	523	13	)	)	-RRB-
cord-001859-d62iuk72	523	14	stabilization	stabilization	NN
cord-001859-d62iuk72	523	15	of	of	IN
cord-001859-d62iuk72	523	16	essential	essential	JJ
cord-001859-d62iuk72	523	17	viral	viral	JJ
cord-001859-d62iuk72	523	18	proteins	protein	NNS
cord-001859-d62iuk72	523	19	,	,	,
cord-001859-d62iuk72	523	20	2	2	CD
cord-001859-d62iuk72	523	21	)	)	-RRB-
cord-001859-d62iuk72	523	22	clearing	clearing	NN
cord-001859-d62iuk72	523	23	stalled	stall	VBN
cord-001859-d62iuk72	523	24	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	523	25	during	during	IN
cord-001859-d62iuk72	523	26	times	time	NNS
cord-001859-d62iuk72	523	27	of	of	IN
cord-001859-d62iuk72	523	28	robust	robust	JJ
cord-001859-d62iuk72	523	29	viral	viral	JJ
cord-001859-d62iuk72	523	30	transcription	transcription	NN
cord-001859-d62iuk72	523	31	,	,	,
cord-001859-d62iuk72	523	32	3	3	CD
cord-001859-d62iuk72	523	33	)	)	-RRB-
cord-001859-d62iuk72	523	34	activation	activation	NN
cord-001859-d62iuk72	523	35	of	of	IN
cord-001859-d62iuk72	523	36	viral	viral	JJ
cord-001859-d62iuk72	523	37	promoters	promoter	NNS
cord-001859-d62iuk72	523	38	,	,	,
cord-001859-d62iuk72	523	39	4	4	CD
cord-001859-d62iuk72	523	40	)	)	-RRB-
cord-001859-d62iuk72	523	41	formation	formation	NN
cord-001859-d62iuk72	523	42	of	of	IN
cord-001859-d62iuk72	523	43	KSHV	KSHV	NNP
cord-001859-d62iuk72	523	44	RTCs	RTCs	NNP
cord-001859-d62iuk72	523	45	.	.	.
cord-001859-d62iuk72	524	1	Initially	initially	RB
cord-001859-d62iuk72	524	2	we	-PRON-	PRP
cord-001859-d62iuk72	524	3	hypothesised	hypothesise	VBD
cord-001859-d62iuk72	524	4	that	that	IN
cord-001859-d62iuk72	524	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	524	6	isoforms	isoform	NNS
cord-001859-d62iuk72	524	7	may	may	MD
cord-001859-d62iuk72	524	8	be	be	VB
cord-001859-d62iuk72	524	9	necessary	necessary	JJ
cord-001859-d62iuk72	524	10	for	for	IN
cord-001859-d62iuk72	524	11	maintaining	maintain	VBG
cord-001859-d62iuk72	524	12	the	the	DT
cord-001859-d62iuk72	524	13	stability	stability	NN
cord-001859-d62iuk72	524	14	of	of	IN
cord-001859-d62iuk72	524	15	the	the	DT
cord-001859-d62iuk72	524	16	key	key	JJ
cord-001859-d62iuk72	524	17	KSHV	KSHV	NNP
cord-001859-d62iuk72	524	18	viral	viral	JJ
cord-001859-d62iuk72	524	19	proteins	protein	NNS
cord-001859-d62iuk72	524	20	RTA	RTA	NNP
cord-001859-d62iuk72	525	1	and/or	and/or	CC
cord-001859-d62iuk72	526	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	526	2	.	.	.
cord-001859-d62iuk72	527	1	This	this	DT
cord-001859-d62iuk72	527	2	was	be	VBD
cord-001859-d62iuk72	527	3	deemed	deem	VBN
cord-001859-d62iuk72	527	4	a	a	DT
cord-001859-d62iuk72	527	5	possibility	possibility	NN
cord-001859-d62iuk72	527	6	as	as	IN
cord-001859-d62iuk72	527	7	during	during	IN
cord-001859-d62iuk72	527	8	KSHV	KSHV	NNP
cord-001859-d62iuk72	527	9	latency	latency	NNP
cord-001859-d62iuk72	527	10	,	,	,
cord-001859-d62iuk72	527	11	the	the	DT
cord-001859-d62iuk72	527	12	essential	essential	JJ
cord-001859-d62iuk72	527	13	viral	viral	JJ
cord-001859-d62iuk72	527	14	latency	latency	NN
cord-001859-d62iuk72	527	15	associated	associate	VBD
cord-001859-d62iuk72	527	16	nuclear	nuclear	JJ
cord-001859-d62iuk72	527	17	antigen	antigen	NN
cord-001859-d62iuk72	527	18	(	(	-LRB-
cord-001859-d62iuk72	527	19	LANA	LANA	NNP
cord-001859-d62iuk72	527	20	)	)	-RRB-
cord-001859-d62iuk72	527	21	protein	protein	NN
cord-001859-d62iuk72	527	22	has	have	VBZ
cord-001859-d62iuk72	527	23	been	be	VBN
cord-001859-d62iuk72	527	24	recently	recently	RB
cord-001859-d62iuk72	527	25	shown	show	VBN
cord-001859-d62iuk72	527	26	to	to	TO
cord-001859-d62iuk72	527	27	be	be	VB
cord-001859-d62iuk72	527	28	a	a	DT
cord-001859-d62iuk72	527	29	client	client	NN
cord-001859-d62iuk72	527	30	protein	protein	NN
cord-001859-d62iuk72	527	31	of	of	IN
cord-001859-d62iuk72	527	32	the	the	DT
cord-001859-d62iuk72	527	33	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	527	34	chaperone	chaperone	NN
cord-001859-d62iuk72	527	35	and	and	CC
cord-001859-d62iuk72	527	36	several	several	JJ
cord-001859-d62iuk72	527	37	HSP90	HSP90	NNP
cord-001859-d62iuk72	527	38	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	528	1	reduced	reduce	VBD
cord-001859-d62iuk72	528	2	the	the	DT
cord-001859-d62iuk72	528	3	expression	expression	NN
cord-001859-d62iuk72	528	4	of	of	IN
cord-001859-d62iuk72	528	5	LANA	LANA	NNP
cord-001859-d62iuk72	528	6	[	[	-LRB-
cord-001859-d62iuk72	528	7	41	41	CD
cord-001859-d62iuk72	528	8	]	]	-RRB-
cord-001859-d62iuk72	528	9	.	.	.
cord-001859-d62iuk72	529	1	In	in	IN
cord-001859-d62iuk72	529	2	addition	addition	NN
cord-001859-d62iuk72	529	3	,	,	,
cord-001859-d62iuk72	529	4	the	the	DT
cord-001859-d62iuk72	529	5	lytic	lytic	JJ
cord-001859-d62iuk72	529	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	529	7	K1	K1	NNP
cord-001859-d62iuk72	529	8	glycoprotein	glycoprotein	NN
cord-001859-d62iuk72	529	9	has	have	VBZ
cord-001859-d62iuk72	529	10	also	also	RB
cord-001859-d62iuk72	529	11	been	be	VBN
cord-001859-d62iuk72	529	12	reported	report	VBN
cord-001859-d62iuk72	529	13	to	to	TO
cord-001859-d62iuk72	529	14	be	be	VB
cord-001859-d62iuk72	529	15	a	a	DT
cord-001859-d62iuk72	529	16	client	client	NN
cord-001859-d62iuk72	529	17	protein	protein	NN
cord-001859-d62iuk72	529	18	of	of	IN
cord-001859-d62iuk72	529	19	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	529	20	[	[	-LRB-
cord-001859-d62iuk72	529	21	92	92	CD
cord-001859-d62iuk72	529	22	]	]	-RRB-
cord-001859-d62iuk72	529	23	.	.	.
cord-001859-d62iuk72	530	1	However	however	RB
cord-001859-d62iuk72	530	2	,	,	,
cord-001859-d62iuk72	530	3	inhibition	inhibition	NN
cord-001859-d62iuk72	530	4	of	of	IN
cord-001859-d62iuk72	530	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	530	6	isoforms	isoform	NNS
cord-001859-d62iuk72	530	7	did	do	VBD
cord-001859-d62iuk72	530	8	not	not	RB
cord-001859-d62iuk72	530	9	alter	alter	VB
cord-001859-d62iuk72	530	10	the	the	DT
cord-001859-d62iuk72	530	11	half	half	JJ
cord-001859-d62iuk72	530	12	-	-	HYPH
cord-001859-d62iuk72	530	13	life	life	NN
cord-001859-d62iuk72	530	14	of	of	IN
cord-001859-d62iuk72	530	15	RTA	RTA	NNP
cord-001859-d62iuk72	530	16	or	or	CC
cord-001859-d62iuk72	530	17	ORF57	ORF57	NNP
cord-001859-d62iuk72	531	1	(	(	-LRB-
cord-001859-d62iuk72	531	2	Figs	Figs	NNP
cord-001859-d62iuk72	531	3	3D	3d	NN
cord-001859-d62iuk72	531	4	and	and	CC
cord-001859-d62iuk72	531	5	4D	4d	CD
cord-001859-d62iuk72	531	6	)	)	-RRB-
cord-001859-d62iuk72	531	7	.	.	.
cord-001859-d62iuk72	532	1	Alternatively	alternatively	RB
cord-001859-d62iuk72	532	2	,	,	,
cord-001859-d62iuk72	532	3	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	532	4	has	have	VBZ
cord-001859-d62iuk72	532	5	been	be	VBN
cord-001859-d62iuk72	532	6	observed	observe	VBN
cord-001859-d62iuk72	532	7	at	at	IN
cord-001859-d62iuk72	532	8	the	the	DT
cord-001859-d62iuk72	532	9	periphery	periphery	NN
cord-001859-d62iuk72	532	10	of	of	IN
cord-001859-d62iuk72	532	11	HSV-1	hsv-1	NN
cord-001859-d62iuk72	532	12	RTCs	rtc	NNS
cord-001859-d62iuk72	532	13	where	where	WRB
cord-001859-d62iuk72	532	14	it	-PRON-	PRP
cord-001859-d62iuk72	532	15	is	be	VBZ
cord-001859-d62iuk72	532	16	also	also	RB
cord-001859-d62iuk72	532	17	believed	believe	VBN
cord-001859-d62iuk72	532	18	to	to	TO
cord-001859-d62iuk72	532	19	aid	aid	VB
cord-001859-d62iuk72	532	20	in	in	IN
cord-001859-d62iuk72	532	21	clearing	clear	VBG
cord-001859-d62iuk72	532	22	stalled	stall	VBN
cord-001859-d62iuk72	532	23	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	532	24	from	from	IN
cord-001859-d62iuk72	532	25	viral	viral	JJ
cord-001859-d62iuk72	532	26	genomes	genome	NNS
cord-001859-d62iuk72	532	27	during	during	IN
cord-001859-d62iuk72	532	28	times	time	NNS
cord-001859-d62iuk72	532	29	of	of	IN
cord-001859-d62iuk72	532	30	active	active	JJ
cord-001859-d62iuk72	532	31	transcription	transcription	NN
cord-001859-d62iuk72	532	32	[	[	-LRB-
cord-001859-d62iuk72	532	33	76	76	CD
cord-001859-d62iuk72	532	34	]	]	-RRB-
cord-001859-d62iuk72	532	35	.	.	.
cord-001859-d62iuk72	533	1	Indeed	indeed	RB
cord-001859-d62iuk72	533	2	,	,	,
cord-001859-d62iuk72	533	3	the	the	DT
cord-001859-d62iuk72	533	4	serine-2	serine-2	NNP
cord-001859-d62iuk72	533	5	phosphorylated	phosphorylated	JJ
cord-001859-d62iuk72	533	6	form	form	NN
cord-001859-d62iuk72	533	7	of	of	IN
cord-001859-d62iuk72	533	8	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	533	9	undergoes	undergo	VBZ
cord-001859-d62iuk72	533	10	ubiquitination	ubiquitination	NN
cord-001859-d62iuk72	533	11	and	and	CC
cord-001859-d62iuk72	533	12	robust	robust	JJ
cord-001859-d62iuk72	533	13	proteasomal	proteasomal	JJ
cord-001859-d62iuk72	533	14	degradation	degradation	NN
cord-001859-d62iuk72	533	15	during	during	IN
cord-001859-d62iuk72	533	16	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	533	17	infection	infection	NN
cord-001859-d62iuk72	533	18	[	[	-LRB-
cord-001859-d62iuk72	533	19	93	93	CD
cord-001859-d62iuk72	533	20	]	]	-RRB-
cord-001859-d62iuk72	533	21	.	.	.
cord-001859-d62iuk72	534	1	In	in	IN
cord-001859-d62iuk72	534	2	contrast	contrast	NN
cord-001859-d62iuk72	534	3	,	,	,
cord-001859-d62iuk72	534	4	in	in	IN
cord-001859-d62iuk72	534	5	KSHV	KSHV	NNP
cord-001859-d62iuk72	534	6	-	-	HYPH
cord-001859-d62iuk72	534	7	reactivated	reactivate	VBN
cord-001859-d62iuk72	534	8	cells	cell	NNS
cord-001859-d62iuk72	534	9	,	,	,
cord-001859-d62iuk72	534	10	there	there	EX
cord-001859-d62iuk72	534	11	was	be	VBD
cord-001859-d62iuk72	534	12	only	only	RB
cord-001859-d62iuk72	534	13	a	a	DT
cord-001859-d62iuk72	534	14	slight	slight	JJ
cord-001859-d62iuk72	534	15	reduction	reduction	NN
cord-001859-d62iuk72	534	16	of	of	IN
cord-001859-d62iuk72	534	17	serine-2	serine-2	NNP
cord-001859-d62iuk72	534	18	phosphorylated	phosphorylated	JJ
cord-001859-d62iuk72	534	19	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	534	20	in	in	IN
cord-001859-d62iuk72	534	21	comparison	comparison	NN
cord-001859-d62iuk72	534	22	with	with	IN
cord-001859-d62iuk72	534	23	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	534	24	cells	cell	NNS
cord-001859-d62iuk72	534	25	even	even	RB
cord-001859-d62iuk72	534	26	at	at	IN
cord-001859-d62iuk72	534	27	late	late	JJ
cord-001859-d62iuk72	534	28	times	time	NNS
cord-001859-d62iuk72	534	29	(	(	-LRB-
cord-001859-d62iuk72	534	30	24	24	CD
cord-001859-d62iuk72	534	31	h	h	NNP
cord-001859-d62iuk72	534	32	)	)	-RRB-
cord-001859-d62iuk72	534	33	post	post	JJ
cord-001859-d62iuk72	534	34	-	-	JJ
cord-001859-d62iuk72	534	35	reactivation	reactivation	JJ
cord-001859-d62iuk72	534	36	(	(	-LRB-
cord-001859-d62iuk72	534	37	Fig	Fig	NNP
cord-001859-d62iuk72	534	38	3C	3C	NNP
cord-001859-d62iuk72	534	39	)	)	-RRB-
cord-001859-d62iuk72	534	40	and	and	CC
cord-001859-d62iuk72	534	41	a	a	DT
cord-001859-d62iuk72	534	42	significant	significant	JJ
cord-001859-d62iuk72	534	43	decrease	decrease	NN
cord-001859-d62iuk72	534	44	in	in	IN
cord-001859-d62iuk72	534	45	the	the	DT
cord-001859-d62iuk72	534	46	other	other	JJ
cord-001859-d62iuk72	534	47	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	534	48	forms	form	NNS
cord-001859-d62iuk72	534	49	was	be	VBD
cord-001859-d62iuk72	534	50	not	not	RB
cord-001859-d62iuk72	534	51	evident	evident	JJ
cord-001859-d62iuk72	534	52	(	(	-LRB-
cord-001859-d62iuk72	534	53	Fig	Fig	NNP
cord-001859-d62iuk72	534	54	3C	3c	NN
cord-001859-d62iuk72	534	55	)	)	-RRB-
cord-001859-d62iuk72	534	56	.	.	.
cord-001859-d62iuk72	535	1	This	this	DT
cord-001859-d62iuk72	535	2	suggests	suggest	VBZ
cord-001859-d62iuk72	535	3	that	that	IN
cord-001859-d62iuk72	535	4	although	although	IN
cord-001859-d62iuk72	535	5	robust	robust	JJ
cord-001859-d62iuk72	535	6	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	535	7	degradation	degradation	NN
cord-001859-d62iuk72	535	8	is	be	VBZ
cord-001859-d62iuk72	535	9	a	a	DT
cord-001859-d62iuk72	535	10	feature	feature	NN
cord-001859-d62iuk72	535	11	observed	observe	VBN
cord-001859-d62iuk72	535	12	in	in	IN
cord-001859-d62iuk72	535	13	virus	virus	NN
cord-001859-d62iuk72	535	14	infection	infection	NN
cord-001859-d62iuk72	535	15	,	,	,
cord-001859-d62iuk72	535	16	such	such	JJ
cord-001859-d62iuk72	535	17	as	as	IN
cord-001859-d62iuk72	535	18	HSV-1	hsv-1	NN
cord-001859-d62iuk72	535	19	and	and	CC
cord-001859-d62iuk72	535	20	influenza	influenza	NN
cord-001859-d62iuk72	535	21	virus	virus	NN
cord-001859-d62iuk72	535	22	[	[	-LRB-
cord-001859-d62iuk72	535	23	55	55	CD
cord-001859-d62iuk72	535	24	,	,	,
cord-001859-d62iuk72	535	25	93	93	CD
cord-001859-d62iuk72	535	26	]	]	-RRB-
cord-001859-d62iuk72	535	27	,	,	,
cord-001859-d62iuk72	535	28	it	-PRON-	PRP
cord-001859-d62iuk72	535	29	may	may	MD
cord-001859-d62iuk72	535	30	not	not	RB
cord-001859-d62iuk72	535	31	be	be	VB
cord-001859-d62iuk72	535	32	universally	universally	RB
cord-001859-d62iuk72	535	33	conserved	conserve	VBN
cord-001859-d62iuk72	535	34	.	.	.
cord-001859-d62iuk72	536	1	It	-PRON-	PRP
cord-001859-d62iuk72	536	2	is	be	VBZ
cord-001859-d62iuk72	536	3	interesting	interesting	JJ
cord-001859-d62iuk72	536	4	to	to	TO
cord-001859-d62iuk72	536	5	note	note	VB
cord-001859-d62iuk72	536	6	that	that	DT
cord-001859-d62iuk72	536	7	expression	expression	NN
cord-001859-d62iuk72	536	8	of	of	IN
cord-001859-d62iuk72	536	9	a	a	DT
cord-001859-d62iuk72	536	10	dominant	dominant	JJ
cord-001859-d62iuk72	536	11	-	-	HYPH
cord-001859-d62iuk72	536	12	negative	negative	JJ
cord-001859-d62iuk72	536	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	536	14	(	(	-LRB-
cord-001859-d62iuk72	536	15	K71	K71	NNP
cord-001859-d62iuk72	536	16	M	M	NNP
cord-001859-d62iuk72	536	17	)	)	-RRB-
cord-001859-d62iuk72	536	18	that	that	WDT
cord-001859-d62iuk72	536	19	can	can	MD
cord-001859-d62iuk72	536	20	not	not	RB
cord-001859-d62iuk72	536	21	hydrolyze	hydrolyze	VB
cord-001859-d62iuk72	536	22	ATP	ATP	NNP
cord-001859-d62iuk72	536	23	during	during	IN
cord-001859-d62iuk72	536	24	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	536	25	infection	infection	NN
cord-001859-d62iuk72	536	26	resulted	result	VBD
cord-001859-d62iuk72	536	27	in	in	IN
cord-001859-d62iuk72	536	28	prevention	prevention	NN
cord-001859-d62iuk72	536	29	of	of	IN
cord-001859-d62iuk72	536	30	serine-2	serine-2	NNP
cord-001859-d62iuk72	536	31	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	536	32	degradation	degradation	NN
cord-001859-d62iuk72	536	33	and	and	CC
cord-001859-d62iuk72	536	34	RTCs	rtcs	NN
cord-001859-d62iuk72	536	35	formation	formation	NN
cord-001859-d62iuk72	536	36	[	[	-LRB-
cord-001859-d62iuk72	536	37	76	76	CD
cord-001859-d62iuk72	536	38	]	]	-RRB-
cord-001859-d62iuk72	536	39	.	.	.
cord-001859-d62iuk72	537	1	However	however	RB
cord-001859-d62iuk72	537	2	,	,	,
cord-001859-d62iuk72	537	3	inhibition	inhibition	NN
cord-001859-d62iuk72	537	4	of	of	IN
cord-001859-d62iuk72	537	5	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	537	6	isoforms	isoform	NNS
cord-001859-d62iuk72	537	7	by	by	IN
cord-001859-d62iuk72	537	8	VER-155008	VER-155008	NNS
cord-001859-d62iuk72	537	9	did	do	VBD
cord-001859-d62iuk72	537	10	not	not	RB
cord-001859-d62iuk72	537	11	prevent	prevent	VB
cord-001859-d62iuk72	537	12	the	the	DT
cord-001859-d62iuk72	537	13	slight	slight	JJ
cord-001859-d62iuk72	537	14	degradation	degradation	NN
cord-001859-d62iuk72	537	15	of	of	IN
cord-001859-d62iuk72	537	16	phospho	phospho	NNP
cord-001859-d62iuk72	537	17	-	-	HYPH
cord-001859-d62iuk72	537	18	serine-2	serine-2	NNP
cord-001859-d62iuk72	537	19	RNAPII	rnapii	NN
cord-001859-d62iuk72	537	20	protein	protein	NN
cord-001859-d62iuk72	537	21	(	(	-LRB-
cord-001859-d62iuk72	537	22	Fig	Fig	NNP
cord-001859-d62iuk72	537	23	 	 	_SP
cord-001859-d62iuk72	537	24	3C	3c	NN
cord-001859-d62iuk72	537	25	)	)	-RRB-
cord-001859-d62iuk72	537	26	.	.	.
cord-001859-d62iuk72	538	1	Using	use	VBG
cord-001859-d62iuk72	538	2	transient	transient	JJ
cord-001859-d62iuk72	538	3	transfections	transfection	NNS
cord-001859-d62iuk72	538	4	,	,	,
cord-001859-d62iuk72	538	5	we	-PRON-	PRP
cord-001859-d62iuk72	538	6	also	also	RB
cord-001859-d62iuk72	538	7	demonstrated	demonstrate	VBD
cord-001859-d62iuk72	538	8	that	that	IN
cord-001859-d62iuk72	538	9	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	538	10	isoforms	isoform	NNS
cord-001859-d62iuk72	538	11	were	be	VBD
cord-001859-d62iuk72	538	12	not	not	RB
cord-001859-d62iuk72	538	13	directly	directly	RB
cord-001859-d62iuk72	538	14	involved	involve	VBN
cord-001859-d62iuk72	538	15	in	in	IN
cord-001859-d62iuk72	538	16	the	the	DT
cord-001859-d62iuk72	538	17	activation	activation	NN
cord-001859-d62iuk72	538	18	of	of	IN
cord-001859-d62iuk72	538	19	viral	viral	JJ
cord-001859-d62iuk72	538	20	promoters	promoter	NNS
cord-001859-d62iuk72	538	21	(	(	-LRB-
cord-001859-d62iuk72	538	22	Fig	Fig	NNP
cord-001859-d62iuk72	538	23	7D	7D	NNP
cord-001859-d62iuk72	538	24	and	and	CC
cord-001859-d62iuk72	538	25	7E	7E	NNP
cord-001859-d62iuk72	538	26	)	)	-RRB-
cord-001859-d62iuk72	538	27	.	.	.
cord-001859-d62iuk72	539	1	Strikingly	strikingly	RB
cord-001859-d62iuk72	539	2	however	however	RB
cord-001859-d62iuk72	539	3	,	,	,
cord-001859-d62iuk72	539	4	inhibition	inhibition	NN
cord-001859-d62iuk72	539	5	of	of	IN
cord-001859-d62iuk72	539	6	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	539	7	isoforms	isoform	NNS
cord-001859-d62iuk72	539	8	precluded	preclude	VBD
cord-001859-d62iuk72	539	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	539	10	RTCs	rtc	NNS
cord-001859-d62iuk72	539	11	formation	formation	NN
cord-001859-d62iuk72	539	12	(	(	-LRB-
cord-001859-d62iuk72	539	13	Fig	fig	NN
cord-001859-d62iuk72	539	14	8)	8)	NN
cord-001859-d62iuk72	539	15	and	and	CC
cord-001859-d62iuk72	539	16	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	539	17	re	re	NN
cord-001859-d62iuk72	539	18	-	-	NN
cord-001859-d62iuk72	539	19	localization	localization	NN
cord-001859-d62iuk72	539	20	to	to	IN
cord-001859-d62iuk72	539	21	viral	viral	JJ
cord-001859-d62iuk72	539	22	promoters	promoter	NNS
cord-001859-d62iuk72	539	23	(	(	-LRB-
cord-001859-d62iuk72	539	24	Fig	Fig	NNP
cord-001859-d62iuk72	539	25	9	9	CD
cord-001859-d62iuk72	539	26	)	)	-RRB-
cord-001859-d62iuk72	539	27	,	,	,
cord-001859-d62iuk72	539	28	thus	thus	RB
cord-001859-d62iuk72	539	29	,	,	,
cord-001859-d62iuk72	539	30	blocking	block	VBG
cord-001859-d62iuk72	539	31	KSHV	KSHV	NNP
cord-001859-d62iuk72	539	32	RTCs	rtcs	NN
cord-001859-d62iuk72	539	33	formation	formation	NN
cord-001859-d62iuk72	539	34	led	lead	VBD
cord-001859-d62iuk72	539	35	to	to	IN
cord-001859-d62iuk72	539	36	abolishment	abolishment	NN
cord-001859-d62iuk72	539	37	of	of	IN
cord-001859-d62iuk72	539	38	global	global	JJ
cord-001859-d62iuk72	539	39	viral	viral	JJ
cord-001859-d62iuk72	539	40	transcription	transcription	NN
cord-001859-d62iuk72	539	41	and	and	CC
cord-001859-d62iuk72	539	42	subsequent	subsequent	JJ
cord-001859-d62iuk72	539	43	protein	protein	NN
cord-001859-d62iuk72	539	44	synthesis	synthesis	NN
cord-001859-d62iuk72	539	45	and	and	CC
cord-001859-d62iuk72	539	46	viral	viral	JJ
cord-001859-d62iuk72	539	47	DNA	dna	NN
cord-001859-d62iuk72	539	48	replication	replication	NN
cord-001859-d62iuk72	539	49	.	.	.
cord-001859-d62iuk72	540	1	These	these	DT
cord-001859-d62iuk72	540	2	results	result	NNS
cord-001859-d62iuk72	540	3	,	,	,
cord-001859-d62iuk72	540	4	taken	take	VBN
cord-001859-d62iuk72	540	5	together	together	RB
cord-001859-d62iuk72	540	6	with	with	IN
cord-001859-d62iuk72	540	7	the	the	DT
cord-001859-d62iuk72	540	8	differential	differential	JJ
cord-001859-d62iuk72	540	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	540	10	and	and	CC
cord-001859-d62iuk72	540	11	iHsp70	ihsp70	IN
cord-001859-d62iuk72	540	12	labelling	labelling	NN
cord-001859-d62iuk72	540	13	seen	see	VBN
cord-001859-d62iuk72	540	14	in	in	IN
cord-001859-d62iuk72	540	15	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	540	16	and	and	CC
cord-001859-d62iuk72	540	17	KSHV	KSHV	NNP
cord-001859-d62iuk72	540	18	-	-	HYPH
cord-001859-d62iuk72	540	19	infected	infect	VBN
cord-001859-d62iuk72	540	20	cells	cell	NNS
cord-001859-d62iuk72	540	21	,	,	,
cord-001859-d62iuk72	540	22	suggest	suggest	VBP
cord-001859-d62iuk72	540	23	that	that	IN
cord-001859-d62iuk72	540	24	these	these	DT
cord-001859-d62iuk72	540	25	chaperones	chaperone	NNS
cord-001859-d62iuk72	540	26	may	may	MD
cord-001859-d62iuk72	540	27	be	be	VB
cord-001859-d62iuk72	540	28	playing	play	VBG
cord-001859-d62iuk72	540	29	additional	additional	JJ
cord-001859-d62iuk72	540	30	roles	role	NNS
cord-001859-d62iuk72	540	31	,	,	,
cord-001859-d62iuk72	540	32	such	such	JJ
cord-001859-d62iuk72	540	33	as	as	IN
cord-001859-d62iuk72	540	34	participating	participate	VBG
cord-001859-d62iuk72	540	35	in	in	IN
cord-001859-d62iuk72	540	36	viral	viral	JJ
cord-001859-d62iuk72	540	37	DNA	dna	NN
cord-001859-d62iuk72	540	38	replication	replication	NN
cord-001859-d62iuk72	540	39	and/or	and/or	CC
cord-001859-d62iuk72	540	40	capsid	capsid	NN
cord-001859-d62iuk72	540	41	assembly	assembly	NN
cord-001859-d62iuk72	540	42	,	,	,
cord-001859-d62iuk72	540	43	in	in	IN
cord-001859-d62iuk72	540	44	KSHV	KSHV	NNP
cord-001859-d62iuk72	540	45	lytic	lytic	JJ
cord-001859-d62iuk72	540	46	infection	infection	NN
cord-001859-d62iuk72	540	47	compared	compare	VBN
cord-001859-d62iuk72	540	48	with	with	IN
cord-001859-d62iuk72	540	49	HSV-1	hsv-1	NN
cord-001859-d62iuk72	540	50	infection	infection	NN
cord-001859-d62iuk72	540	51	.	.	.
cord-001859-d62iuk72	541	1	Importantly	importantly	RB
cord-001859-d62iuk72	541	2	,	,	,
cord-001859-d62iuk72	541	3	in	in	IN
cord-001859-d62iuk72	541	4	both	both	DT
cord-001859-d62iuk72	541	5	viruses	virus	NNS
cord-001859-d62iuk72	541	6	,	,	,
cord-001859-d62iuk72	541	7	HSV-1	hsv-1	NN
cord-001859-d62iuk72	541	8	and	and	CC
cord-001859-d62iuk72	541	9	KSHV	KSHV	NNP
cord-001859-d62iuk72	541	10	,	,	,
cord-001859-d62iuk72	541	11	inhibition	inhibition	NN
cord-001859-d62iuk72	541	12	of	of	IN
cord-001859-d62iuk72	541	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	541	14	ATPase	ATPase	NNP
cord-001859-d62iuk72	541	15	function	function	NN
cord-001859-d62iuk72	541	16	leads	lead	VBZ
cord-001859-d62iuk72	541	17	to	to	IN
cord-001859-d62iuk72	541	18	a	a	DT
cord-001859-d62iuk72	541	19	clear	clear	JJ
cord-001859-d62iuk72	541	20	impediment	impediment	NN
cord-001859-d62iuk72	541	21	in	in	IN
cord-001859-d62iuk72	541	22	RTCs	RTCs	NNP
cord-001859-d62iuk72	541	23	formation	formation	NN
cord-001859-d62iuk72	541	24	and	and	CC
cord-001859-d62iuk72	541	25	presents	present	VBZ
cord-001859-d62iuk72	541	26	a	a	DT
cord-001859-d62iuk72	541	27	novel	novel	JJ
cord-001859-d62iuk72	541	28	antiviral	antiviral	JJ
cord-001859-d62iuk72	541	29	target	target	NN
cord-001859-d62iuk72	541	30	for	for	IN
cord-001859-d62iuk72	541	31	multiple	multiple	JJ
cord-001859-d62iuk72	541	32	herpesviruses	herpesviruse	NNS
cord-001859-d62iuk72	541	33	.	.	.
cord-001859-d62iuk72	542	1	Moreover	moreover	RB
cord-001859-d62iuk72	542	2	,	,	,
cord-001859-d62iuk72	542	3	as	as	IN
cord-001859-d62iuk72	542	4	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	542	5	and	and	CC
cord-001859-d62iuk72	542	6	KSHV	KSHV	NNP
cord-001859-d62iuk72	542	7	belong	belong	VBP
cord-001859-d62iuk72	542	8	to	to	IN
cord-001859-d62iuk72	542	9	different	different	JJ
cord-001859-d62iuk72	542	10	subfamilies	subfamily	NNS
cord-001859-d62iuk72	542	11	of	of	IN
cord-001859-d62iuk72	542	12	the	the	DT
cord-001859-d62iuk72	542	13	Herpesviridae	Herpesviridae	NNP
cord-001859-d62iuk72	542	14	family	family	NN
cord-001859-d62iuk72	542	15	(	(	-LRB-
cord-001859-d62iuk72	542	16	α	α	NN
cord-001859-d62iuk72	542	17	and	and	CC
cord-001859-d62iuk72	542	18	γ	γ	NN
cord-001859-d62iuk72	542	19	subfamily	subfamily	NN
cord-001859-d62iuk72	542	20	respectively	respectively	RB
cord-001859-d62iuk72	542	21	)	)	-RRB-
cord-001859-d62iuk72	542	22	,	,	,
cord-001859-d62iuk72	542	23	the	the	DT
cord-001859-d62iuk72	542	24	key	key	JJ
cord-001859-d62iuk72	542	25	role	role	NN
cord-001859-d62iuk72	542	26	of	of	IN
cord-001859-d62iuk72	542	27	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	542	28	isoforms	isoform	NNS
cord-001859-d62iuk72	542	29	in	in	IN
cord-001859-d62iuk72	542	30	RTC	RTC	NNP
cord-001859-d62iuk72	542	31	formation	formation	NN
cord-001859-d62iuk72	542	32	may	may	MD
cord-001859-d62iuk72	542	33	be	be	VB
cord-001859-d62iuk72	542	34	conserved	conserve	VBN
cord-001859-d62iuk72	542	35	across	across	IN
cord-001859-d62iuk72	542	36	all	all	DT
cord-001859-d62iuk72	542	37	subfamilies	subfamily	NNS
cord-001859-d62iuk72	542	38	.	.	.
cord-001859-d62iuk72	543	1	In	in	IN
cord-001859-d62iuk72	543	2	support	support	NN
cord-001859-d62iuk72	543	3	of	of	IN
cord-001859-d62iuk72	543	4	this	this	DT
cord-001859-d62iuk72	543	5	notion	notion	NN
cord-001859-d62iuk72	543	6	is	be	VBZ
cord-001859-d62iuk72	543	7	the	the	DT
cord-001859-d62iuk72	543	8	fact	fact	NN
cord-001859-d62iuk72	543	9	that	that	IN
cord-001859-d62iuk72	543	10	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	543	11	and	and	CC
cord-001859-d62iuk72	543	12	iHsp70	ihsp70	TO
cord-001859-d62iuk72	543	13	have	have	VBP
cord-001859-d62iuk72	543	14	also	also	RB
cord-001859-d62iuk72	543	15	been	be	VBN
cord-001859-d62iuk72	543	16	reported	report	VBN
cord-001859-d62iuk72	543	17	to	to	TO
cord-001859-d62iuk72	543	18	be	be	VB
cord-001859-d62iuk72	543	19	incorporated	incorporate	VBN
cord-001859-d62iuk72	543	20	in	in	IN
cord-001859-d62iuk72	543	21	the	the	DT
cord-001859-d62iuk72	543	22	virion	virion	NN
cord-001859-d62iuk72	543	23	of	of	IN
cord-001859-d62iuk72	543	24	the	the	DT
cord-001859-d62iuk72	543	25	β	β	NN
cord-001859-d62iuk72	543	26	-	-	HYPH
cord-001859-d62iuk72	543	27	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	543	28	HCMV	HCMV	NNP
cord-001859-d62iuk72	543	29	[	[	-LRB-
cord-001859-d62iuk72	543	30	94	94	CD
cord-001859-d62iuk72	543	31	]	]	-RRB-
cord-001859-d62iuk72	543	32	and	and	CC
cord-001859-d62iuk72	543	33	the	the	DT
cord-001859-d62iuk72	543	34	γ	γ	NN
cord-001859-d62iuk72	543	35	-	-	HYPH
cord-001859-d62iuk72	543	36	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	543	37	EBV	EBV	NNP
cord-001859-d62iuk72	543	38	[	[	-LRB-
cord-001859-d62iuk72	543	39	95	95	CD
cord-001859-d62iuk72	543	40	]	]	-RRB-
cord-001859-d62iuk72	543	41	.	.	.
cord-001859-d62iuk72	544	1	Our	-PRON-	PRP$
cord-001859-d62iuk72	544	2	results	result	NNS
cord-001859-d62iuk72	544	3	also	also	RB
cord-001859-d62iuk72	544	4	support	support	VBP
cord-001859-d62iuk72	544	5	that	that	IN
cord-001859-d62iuk72	544	6	the	the	DT
cord-001859-d62iuk72	544	7	finding	finding	NN
cord-001859-d62iuk72	544	8	of	of	IN
cord-001859-d62iuk72	544	9	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	544	10	and	and	CC
cord-001859-d62iuk72	544	11	iHsp70	ihsp70	IN
cord-001859-d62iuk72	544	12	chaperones	chaperone	NNS
cord-001859-d62iuk72	544	13	in	in	IN
cord-001859-d62iuk72	544	14	the	the	DT
cord-001859-d62iuk72	544	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	544	16	virion	virion	NN
cord-001859-d62iuk72	544	17	[	[	-LRB-
cord-001859-d62iuk72	544	18	86	86	CD
cord-001859-d62iuk72	544	19	,	,	,
cord-001859-d62iuk72	544	20	87	87	CD
cord-001859-d62iuk72	544	21	]	]	-RRB-
cord-001859-d62iuk72	544	22	a	a	DT
cord-001859-d62iuk72	544	23	decade	decade	NN
cord-001859-d62iuk72	544	24	ago	ago	RB
cord-001859-d62iuk72	544	25	was	be	VBD
cord-001859-d62iuk72	544	26	not	not	RB
cord-001859-d62iuk72	544	27	casual	casual	JJ
cord-001859-d62iuk72	544	28	,	,	,
cord-001859-d62iuk72	544	29	and	and	CC
cord-001859-d62iuk72	544	30	that	that	IN
cord-001859-d62iuk72	544	31	these	these	DT
cord-001859-d62iuk72	544	32	chaperones	chaperone	NNS
cord-001859-d62iuk72	544	33	are	be	VBP
cord-001859-d62iuk72	544	34	essential	essential	JJ
cord-001859-d62iuk72	544	35	for	for	IN
cord-001859-d62iuk72	544	36	KSHV	KSHV	NNP
cord-001859-d62iuk72	544	37	RTCs	rtcs	NN
cord-001859-d62iuk72	544	38	formation	formation	NN
cord-001859-d62iuk72	544	39	during	during	IN
cord-001859-d62iuk72	544	40	lytic	lytic	JJ
cord-001859-d62iuk72	544	41	replication	replication	NN
cord-001859-d62iuk72	544	42	.	.	.
cord-001859-d62iuk72	545	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	545	2	has	have	VBZ
cord-001859-d62iuk72	545	3	also	also	RB
cord-001859-d62iuk72	545	4	been	be	VBN
cord-001859-d62iuk72	545	5	detected	detect	VBN
cord-001859-d62iuk72	545	6	in	in	IN
cord-001859-d62iuk72	545	7	the	the	DT
cord-001859-d62iuk72	545	8	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	545	9	virion	virion	NN
cord-001859-d62iuk72	545	10	[	[	-LRB-
cord-001859-d62iuk72	545	11	96	96	CD
cord-001859-d62iuk72	545	12	]	]	-RRB-
cord-001859-d62iuk72	545	13	.	.	.
cord-001859-d62iuk72	546	1	To	to	TO
cord-001859-d62iuk72	546	2	support	support	VB
cord-001859-d62iuk72	546	3	the	the	DT
cord-001859-d62iuk72	546	4	conserved	conserved	JJ
cord-001859-d62iuk72	546	5	role	role	NN
cord-001859-d62iuk72	546	6	of	of	IN
cord-001859-d62iuk72	546	7	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	546	8	isoforms	isoform	NNS
cord-001859-d62iuk72	546	9	in	in	IN
cord-001859-d62iuk72	546	10	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	546	11	infection	infection	NN
cord-001859-d62iuk72	546	12	,	,	,
cord-001859-d62iuk72	546	13	a	a	DT
cord-001859-d62iuk72	546	14	recent	recent	JJ
cord-001859-d62iuk72	546	15	study	study	NN
cord-001859-d62iuk72	546	16	showed	show	VBD
cord-001859-d62iuk72	546	17	that	that	IN
cord-001859-d62iuk72	546	18	cellular	cellular	JJ
cord-001859-d62iuk72	546	19	depletion	depletion	NN
cord-001859-d62iuk72	546	20	of	of	IN
cord-001859-d62iuk72	546	21	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	546	22	protein	protein	NN
cord-001859-d62iuk72	546	23	significantly	significantly	RB
cord-001859-d62iuk72	546	24	reduced	reduce	VBD
cord-001859-d62iuk72	546	25	HSV-1	hsv-1	NN
cord-001859-d62iuk72	546	26	viral	viral	JJ
cord-001859-d62iuk72	546	27	output	output	NN
cord-001859-d62iuk72	546	28	in	in	IN
cord-001859-d62iuk72	546	29	cell	cell	NN
cord-001859-d62iuk72	546	30	culture	culture	NN
cord-001859-d62iuk72	546	31	without	without	IN
cord-001859-d62iuk72	546	32	adversely	adversely	RB
cord-001859-d62iuk72	546	33	affecting	affect	VBG
cord-001859-d62iuk72	546	34	cell	cell	NN
cord-001859-d62iuk72	546	35	viability	viability	NN
cord-001859-d62iuk72	546	36	.	.	.
cord-001859-d62iuk72	547	1	Depleting	deplete	VBG
cord-001859-d62iuk72	547	2	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	547	3	from	from	IN
cord-001859-d62iuk72	547	4	the	the	DT
cord-001859-d62iuk72	547	5	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	547	6	virion	virion	NN
cord-001859-d62iuk72	547	7	also	also	RB
cord-001859-d62iuk72	547	8	significantly	significantly	RB
cord-001859-d62iuk72	547	9	reduced	reduce	VBD
cord-001859-d62iuk72	547	10	viral	viral	JJ
cord-001859-d62iuk72	547	11	production	production	NN
cord-001859-d62iuk72	547	12	by	by	IN
cord-001859-d62iuk72	547	13	more	more	JJR
cord-001859-d62iuk72	547	14	than	than	IN
cord-001859-d62iuk72	547	15	50	50	CD
cord-001859-d62iuk72	547	16	%	%	NN
cord-001859-d62iuk72	547	17	[	[	-LRB-
cord-001859-d62iuk72	547	18	97	97	CD
cord-001859-d62iuk72	547	19	]	]	-RRB-
cord-001859-d62iuk72	547	20	.	.	.
cord-001859-d62iuk72	548	1	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	548	2	isoforms	isoform	NNS
cord-001859-d62iuk72	548	3	may	may	MD
cord-001859-d62iuk72	548	4	be	be	VB
cord-001859-d62iuk72	548	5	recruited	recruit	VBN
cord-001859-d62iuk72	548	6	to	to	IN
cord-001859-d62iuk72	548	7	RTCs	rtc	NNS
cord-001859-d62iuk72	548	8	for	for	IN
cord-001859-d62iuk72	548	9	several	several	JJ
cord-001859-d62iuk72	548	10	reasons	reason	NNS
cord-001859-d62iuk72	548	11	.	.	.
cord-001859-d62iuk72	549	1	Firstly	firstly	RB
cord-001859-d62iuk72	549	2	,	,	,
cord-001859-d62iuk72	549	3	the	the	DT
cord-001859-d62iuk72	549	4	chaperone	chaperone	NN
cord-001859-d62iuk72	549	5	may	may	MD
cord-001859-d62iuk72	549	6	sequester	sequester	VB
cord-001859-d62iuk72	549	7	misfolded	misfolde	VBN
cord-001859-d62iuk72	549	8	,	,	,
cord-001859-d62iuk72	549	9	modified	modified	JJ
cord-001859-d62iuk72	549	10	or	or	CC
cord-001859-d62iuk72	549	11	unwanted	unwanted	JJ
cord-001859-d62iuk72	549	12	proteins	protein	NNS
cord-001859-d62iuk72	549	13	away	away	RB
cord-001859-d62iuk72	549	14	from	from	IN
cord-001859-d62iuk72	549	15	RTCs	rtc	NNS
cord-001859-d62iuk72	549	16	.	.	.
cord-001859-d62iuk72	550	1	Alternatively	alternatively	RB
cord-001859-d62iuk72	550	2	,	,	,
cord-001859-d62iuk72	550	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	550	4	could	could	MD
cord-001859-d62iuk72	550	5	produce	produce	VB
cord-001859-d62iuk72	550	6	a	a	DT
cord-001859-d62iuk72	550	7	site	site	NN
cord-001859-d62iuk72	550	8	for	for	IN
cord-001859-d62iuk72	550	9	protein	protein	NN
cord-001859-d62iuk72	550	10	remodelling	remodelling	NN
cord-001859-d62iuk72	550	11	and/or	and/or	CC
cord-001859-d62iuk72	550	12	degradation	degradation	NN
cord-001859-d62iuk72	550	13	which	which	WDT
cord-001859-d62iuk72	550	14	may	may	MD
cord-001859-d62iuk72	550	15	regulate	regulate	VB
cord-001859-d62iuk72	550	16	or	or	CC
cord-001859-d62iuk72	550	17	delay	delay	VB
cord-001859-d62iuk72	550	18	cellular	cellular	JJ
cord-001859-d62iuk72	550	19	pathways	pathway	NNS
cord-001859-d62iuk72	550	20	,	,	,
cord-001859-d62iuk72	550	21	such	such	JJ
cord-001859-d62iuk72	550	22	as	as	IN
cord-001859-d62iuk72	550	23	the	the	DT
cord-001859-d62iuk72	550	24	apoptosis	apoptosis	NN
cord-001859-d62iuk72	550	25	cascade	cascade	NN
cord-001859-d62iuk72	550	26	.	.	.
cord-001859-d62iuk72	551	1	Finally	finally	RB
cord-001859-d62iuk72	551	2	,	,	,
cord-001859-d62iuk72	551	3	it	-PRON-	PRP
cord-001859-d62iuk72	551	4	may	may	MD
cord-001859-d62iuk72	551	5	aid	aid	VB
cord-001859-d62iuk72	551	6	subtlety	subtlety	NN
cord-001859-d62iuk72	551	7	to	to	TO
cord-001859-d62iuk72	551	8	clear	clear	VB
cord-001859-d62iuk72	551	9	stalled	stall	VBN
cord-001859-d62iuk72	551	10	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	551	11	complexes	complex	NNS
cord-001859-d62iuk72	551	12	during	during	IN
cord-001859-d62iuk72	551	13	robust	robust	JJ
cord-001859-d62iuk72	551	14	viral	viral	JJ
cord-001859-d62iuk72	551	15	transcription	transcription	NN
cord-001859-d62iuk72	551	16	and	and	CC
cord-001859-d62iuk72	551	17	replication	replication	NN
cord-001859-d62iuk72	551	18	.	.	.
cord-001859-d62iuk72	552	1	An	an	DT
cord-001859-d62iuk72	552	2	additional	additional	JJ
cord-001859-d62iuk72	552	3	question	question	NN
cord-001859-d62iuk72	552	4	which	which	WDT
cord-001859-d62iuk72	552	5	is	be	VBZ
cord-001859-d62iuk72	552	6	yet	yet	RB
cord-001859-d62iuk72	552	7	to	to	TO
cord-001859-d62iuk72	552	8	be	be	VB
cord-001859-d62iuk72	552	9	addressed	address	VBN
cord-001859-d62iuk72	552	10	is	be	VBZ
cord-001859-d62iuk72	552	11	the	the	DT
cord-001859-d62iuk72	552	12	mechanism	mechanism	NN
cord-001859-d62iuk72	552	13	by	by	IN
cord-001859-d62iuk72	552	14	which	which	WDT
cord-001859-d62iuk72	552	15	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	552	16	isoforms	isoform	NNS
cord-001859-d62iuk72	552	17	are	be	VBP
cord-001859-d62iuk72	552	18	recruited	recruit	VBN
cord-001859-d62iuk72	552	19	to	to	IN
cord-001859-d62iuk72	552	20	RTCs	RTCs	NNP
cord-001859-d62iuk72	552	21	.	.	.
cord-001859-d62iuk72	553	1	One	one	CD
cord-001859-d62iuk72	553	2	intriguing	intriguing	JJ
cord-001859-d62iuk72	553	3	possibility	possibility	NN
cord-001859-d62iuk72	553	4	is	be	VBZ
cord-001859-d62iuk72	553	5	observations	observation	NNS
cord-001859-d62iuk72	553	6	made	make	VBN
cord-001859-d62iuk72	553	7	during	during	IN
cord-001859-d62iuk72	553	8	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	553	9	infection	infection	NN
cord-001859-d62iuk72	553	10	.	.	.
cord-001859-d62iuk72	554	1	Here	here	RB
cord-001859-d62iuk72	554	2	,	,	,
cord-001859-d62iuk72	554	3	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	554	4	ICP27	ICP27	NNP
cord-001859-d62iuk72	554	5	has	have	VBZ
cord-001859-d62iuk72	554	6	been	be	VBN
cord-001859-d62iuk72	554	7	shown	show	VBN
cord-001859-d62iuk72	554	8	to	to	TO
cord-001859-d62iuk72	554	9	interact	interact	VB
cord-001859-d62iuk72	554	10	with	with	IN
cord-001859-d62iuk72	554	11	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	554	12	and	and	CC
cord-001859-d62iuk72	554	13	is	be	VBZ
cord-001859-d62iuk72	554	14	required	require	VBN
cord-001859-d62iuk72	554	15	for	for	IN
cord-001859-d62iuk72	554	16	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	554	17	nuclear	nuclear	JJ
cord-001859-d62iuk72	554	18	foci	foci	NN
cord-001859-d62iuk72	554	19	formation	formation	NN
cord-001859-d62iuk72	554	20	[	[	-LRB-
cord-001859-d62iuk72	554	21	76	76	CD
cord-001859-d62iuk72	554	22	]	]	-RRB-
cord-001859-d62iuk72	554	23	.	.	.
cord-001859-d62iuk72	555	1	It	-PRON-	PRP
cord-001859-d62iuk72	555	2	will	will	MD
cord-001859-d62iuk72	555	3	now	now	RB
cord-001859-d62iuk72	555	4	be	be	VB
cord-001859-d62iuk72	555	5	interesting	interesting	JJ
cord-001859-d62iuk72	555	6	to	to	TO
cord-001859-d62iuk72	555	7	determine	determine	VB
cord-001859-d62iuk72	555	8	if	if	IN
cord-001859-d62iuk72	555	9	the	the	DT
cord-001859-d62iuk72	555	10	functional	functional	JJ
cord-001859-d62iuk72	555	11	KSHV	KSHV	NNP
cord-001859-d62iuk72	555	12	homologue	homologue	NN
cord-001859-d62iuk72	555	13	ORF57	ORF57	NNP
cord-001859-d62iuk72	555	14	,	,	,
cord-001859-d62iuk72	555	15	also	also	RB
cord-001859-d62iuk72	555	16	interacts	interact	VBZ
cord-001859-d62iuk72	555	17	with	with	IN
cord-001859-d62iuk72	555	18	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	555	19	and	and	CC
cord-001859-d62iuk72	555	20	whether	whether	IN
cord-001859-d62iuk72	555	21	its	-PRON-	PRP$
cord-001859-d62iuk72	555	22	nucleocytoplasmic	nucleocytoplasmic	NN
cord-001859-d62iuk72	555	23	shuttling	shuttle	VBG
cord-001859-d62iuk72	555	24	ability	ability	NN
cord-001859-d62iuk72	555	25	is	be	VBZ
cord-001859-d62iuk72	555	26	essential	essential	JJ
cord-001859-d62iuk72	555	27	for	for	IN
cord-001859-d62iuk72	555	28	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	555	29	nuclear	nuclear	JJ
cord-001859-d62iuk72	555	30	import	import	NN
cord-001859-d62iuk72	555	31	.	.	.
cord-001859-d62iuk72	556	1	In	in	IN
cord-001859-d62iuk72	556	2	summary	summary	NN
cord-001859-d62iuk72	556	3	,	,	,
cord-001859-d62iuk72	556	4	we	-PRON-	PRP
cord-001859-d62iuk72	556	5	have	have	VBP
cord-001859-d62iuk72	556	6	identified	identify	VBN
cord-001859-d62iuk72	556	7	a	a	DT
cord-001859-d62iuk72	556	8	new	new	JJ
cord-001859-d62iuk72	556	9	essential	essential	JJ
cord-001859-d62iuk72	556	10	role	role	NN
cord-001859-d62iuk72	556	11	for	for	IN
cord-001859-d62iuk72	556	12	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	556	13	isoforms	isoform	NNS
cord-001859-d62iuk72	556	14	during	during	IN
cord-001859-d62iuk72	556	15	the	the	DT
cord-001859-d62iuk72	556	16	formation	formation	NN
cord-001859-d62iuk72	556	17	of	of	IN
cord-001859-d62iuk72	556	18	RTCs	rtc	NNS
cord-001859-d62iuk72	556	19	in	in	IN
cord-001859-d62iuk72	556	20	KSHV	KSHV	NNP
cord-001859-d62iuk72	556	21	lytic	lytic	JJ
cord-001859-d62iuk72	556	22	replication	replication	NN
cord-001859-d62iuk72	556	23	.	.	.
cord-001859-d62iuk72	557	1	Importantly	importantly	RB
cord-001859-d62iuk72	557	2	,	,	,
cord-001859-d62iuk72	557	3	our	-PRON-	PRP$
cord-001859-d62iuk72	557	4	results	result	NNS
cord-001859-d62iuk72	557	5	suggest	suggest	VBP
cord-001859-d62iuk72	557	6	that	that	IN
cord-001859-d62iuk72	557	7	HSP70	HSP70	NNP
cord-001859-d62iuk72	557	8	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	557	9	have	have	VBP
cord-001859-d62iuk72	557	10	the	the	DT
cord-001859-d62iuk72	557	11	potential	potential	NN
cord-001859-d62iuk72	557	12	as	as	IN
cord-001859-d62iuk72	557	13	novel	novel	JJ
cord-001859-d62iuk72	557	14	KSHV	KSHV	NNP
cord-001859-d62iuk72	557	15	antiviral	antiviral	JJ
cord-001859-d62iuk72	557	16	agents	agent	NNS
cord-001859-d62iuk72	557	17	and	and	CC
cord-001859-d62iuk72	557	18	it	-PRON-	PRP
cord-001859-d62iuk72	557	19	would	would	MD
cord-001859-d62iuk72	557	20	now	now	RB
cord-001859-d62iuk72	557	21	be	be	VB
cord-001859-d62iuk72	557	22	interesting	interesting	JJ
cord-001859-d62iuk72	557	23	to	to	TO
cord-001859-d62iuk72	557	24	test	test	VB
cord-001859-d62iuk72	557	25	these	these	DT
cord-001859-d62iuk72	557	26	in	in	IN
cord-001859-d62iuk72	557	27	conjunction	conjunction	NN
cord-001859-d62iuk72	557	28	with	with	IN
cord-001859-d62iuk72	557	29	other	other	JJ
cord-001859-d62iuk72	557	30	molecular	molecular	JJ
cord-001859-d62iuk72	557	31	chaperone	chaperone	NN
cord-001859-d62iuk72	557	32	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	557	33	,	,	,
cord-001859-d62iuk72	557	34	specifically	specifically	RB
cord-001859-d62iuk72	557	35	HSP90	HSP90	VBN
cord-001859-d62iuk72	557	36	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	557	37	[	[	-LRB-
cord-001859-d62iuk72	557	38	41	41	CD
cord-001859-d62iuk72	557	39	]	]	-RRB-
cord-001859-d62iuk72	557	40	,	,	,
cord-001859-d62iuk72	557	41	which	which	WDT
cord-001859-d62iuk72	557	42	have	have	VBP
cord-001859-d62iuk72	557	43	the	the	DT
cord-001859-d62iuk72	557	44	potential	potential	NN
cord-001859-d62iuk72	557	45	to	to	TO
cord-001859-d62iuk72	557	46	eradicate	eradicate	VB
cord-001859-d62iuk72	557	47	latent	latent	JJ
cord-001859-d62iuk72	557	48	KSHV	KSHV	NNP
cord-001859-d62iuk72	557	49	reservoirs	reservoir	NNS
cord-001859-d62iuk72	557	50	in	in	IN
cord-001859-d62iuk72	558	1	both	both	DT
cord-001859-d62iuk72	558	2	in	in	IN
cord-001859-d62iuk72	558	3	vitro	vitro	FW
cord-001859-d62iuk72	558	4	and	and	CC
cord-001859-d62iuk72	558	5	in	in	IN
cord-001859-d62iuk72	558	6	vivo	vivo	NN
cord-001859-d62iuk72	558	7	tumour	tumour	NN
cord-001859-d62iuk72	558	8	models	model	NNS
cord-001859-d62iuk72	558	9	.	.	.
cord-001859-d62iuk72	559	1	TREx	TREx	NNP
cord-001859-d62iuk72	559	2	-	-	HYPH
cord-001859-d62iuk72	559	3	BCBL-1-RTA	bcbl-1-rta	NN
cord-001859-d62iuk72	559	4	cells	cell	NNS
cord-001859-d62iuk72	559	5	(	(	-LRB-
cord-001859-d62iuk72	559	6	kindly	kindly	RB
cord-001859-d62iuk72	559	7	provided	provide	VBN
cord-001859-d62iuk72	559	8	by	by	IN
cord-001859-d62iuk72	559	9	Dr.	Dr.	NNP
cord-001859-d62iuk72	559	10	Jae	Jae	NNP
cord-001859-d62iuk72	559	11	Jung	Jung	NNP
cord-001859-d62iuk72	559	12	,	,	,
cord-001859-d62iuk72	559	13	University	University	NNP
cord-001859-d62iuk72	559	14	of	of	IN
cord-001859-d62iuk72	559	15	Southern	Southern	NNP
cord-001859-d62iuk72	559	16	California	California	NNP
cord-001859-d62iuk72	559	17	)	)	-RRB-
cord-001859-d62iuk72	559	18	are	be	VBP
cord-001859-d62iuk72	559	19	a	a	DT
cord-001859-d62iuk72	559	20	BCBL-1-based	bcbl-1-base	VBN
cord-001859-d62iuk72	559	21	,	,	,
cord-001859-d62iuk72	559	22	primary	primary	JJ
cord-001859-d62iuk72	559	23	effusion	effusion	NN
cord-001859-d62iuk72	559	24	lymphoma	lymphoma	NN
cord-001859-d62iuk72	559	25	(	(	-LRB-
cord-001859-d62iuk72	559	26	PEL	PEL	NNP
cord-001859-d62iuk72	559	27	)	)	-RRB-
cord-001859-d62iuk72	559	28	B	b	NN
cord-001859-d62iuk72	559	29	cell	cell	NN
cord-001859-d62iuk72	559	30	line	line	NN
cord-001859-d62iuk72	559	31	that	that	WDT
cord-001859-d62iuk72	559	32	has	have	VBZ
cord-001859-d62iuk72	559	33	been	be	VBN
cord-001859-d62iuk72	559	34	engineered	engineer	VBN
cord-001859-d62iuk72	559	35	to	to	IN
cord-001859-d62iuk72	559	36	inducibly	inducibly	RB
cord-001859-d62iuk72	559	37	express	express	VB
cord-001859-d62iuk72	559	38	exogenous	exogenous	JJ
cord-001859-d62iuk72	559	39	Myc	Myc	NNP
cord-001859-d62iuk72	559	40	-	-	HYPH
cord-001859-d62iuk72	559	41	tagged	tagged	NNP
cord-001859-d62iuk72	559	42	RTA	RTA	NNP
cord-001859-d62iuk72	559	43	by	by	IN
cord-001859-d62iuk72	559	44	the	the	DT
cord-001859-d62iuk72	559	45	addition	addition	NN
cord-001859-d62iuk72	559	46	of	of	IN
cord-001859-d62iuk72	559	47	doxycycline	doxycycline	NNP
cord-001859-d62iuk72	559	48	,	,	,
cord-001859-d62iuk72	559	49	leading	lead	VBG
cord-001859-d62iuk72	559	50	to	to	IN
cord-001859-d62iuk72	559	51	a	a	DT
cord-001859-d62iuk72	559	52	robust	robust	JJ
cord-001859-d62iuk72	559	53	reactivation	reactivation	NN
cord-001859-d62iuk72	559	54	of	of	IN
cord-001859-d62iuk72	559	55	the	the	DT
cord-001859-d62iuk72	559	56	full	full	JJ
cord-001859-d62iuk72	559	57	KSHV	KSHV	NNP
cord-001859-d62iuk72	559	58	lytic	lytic	JJ
cord-001859-d62iuk72	559	59	cycle	cycle	NN
cord-001859-d62iuk72	559	60	[	[	-LRB-
cord-001859-d62iuk72	559	61	48	48	CD
cord-001859-d62iuk72	559	62	]	]	-RRB-
cord-001859-d62iuk72	559	63	.	.	.
cord-001859-d62iuk72	560	1	The	the	DT
cord-001859-d62iuk72	560	2	rKSHV.219	rKSHV.219	NNPS
cord-001859-d62iuk72	560	3	cell	cell	NN
cord-001859-d62iuk72	560	4	line	line	NN
cord-001859-d62iuk72	560	5	(	(	-LRB-
cord-001859-d62iuk72	560	6	kindly	kindly	RB
cord-001859-d62iuk72	560	7	provided	provide	VBN
cord-001859-d62iuk72	560	8	by	by	IN
cord-001859-d62iuk72	560	9	Dr.	Dr.	NNP
cord-001859-d62iuk72	560	10	Jeffery	Jeffery	NNP
cord-001859-d62iuk72	560	11	Vieira	Vieira	NNP
cord-001859-d62iuk72	560	12	,	,	,
cord-001859-d62iuk72	560	13	University	University	NNP
cord-001859-d62iuk72	560	14	of	of	IN
cord-001859-d62iuk72	560	15	Washington	Washington	NNP
cord-001859-d62iuk72	560	16	,	,	,
cord-001859-d62iuk72	560	17	Seattle	Seattle	NNP
cord-001859-d62iuk72	560	18	,	,	,
cord-001859-d62iuk72	560	19	USA	USA	NNP
cord-001859-d62iuk72	560	20	)	)	-RRB-
cord-001859-d62iuk72	560	21	maintains	maintain	VBZ
cord-001859-d62iuk72	560	22	KSHV	KSHV	NNP
cord-001859-d62iuk72	560	23	as	as	IN
cord-001859-d62iuk72	560	24	a	a	DT
cord-001859-d62iuk72	560	25	latent	latent	JJ
cord-001859-d62iuk72	560	26	infection	infection	NN
cord-001859-d62iuk72	560	27	and	and	CC
cord-001859-d62iuk72	560	28	was	be	VBD
cord-001859-d62iuk72	560	29	generated	generate	VBN
cord-001859-d62iuk72	560	30	by	by	IN
cord-001859-d62iuk72	560	31	infecting	infect	VBG
cord-001859-d62iuk72	560	32	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	560	33	T	T	NNP
cord-001859-d62iuk72	560	34	cells	cell	NNS
cord-001859-d62iuk72	560	35	(	(	-LRB-
cord-001859-d62iuk72	560	36	ATCC	ATCC	NNP
cord-001859-d62iuk72	560	37	)	)	-RRB-
cord-001859-d62iuk72	560	38	with	with	IN
cord-001859-d62iuk72	560	39	a	a	DT
cord-001859-d62iuk72	560	40	recombinant	recombinant	JJ
cord-001859-d62iuk72	560	41	KSHV	KSHV	NNP
cord-001859-d62iuk72	560	42	that	that	WDT
cord-001859-d62iuk72	560	43	contains	contain	VBZ
cord-001859-d62iuk72	560	44	a	a	DT
cord-001859-d62iuk72	560	45	constitutively	constitutively	RB
cord-001859-d62iuk72	560	46	active	active	JJ
cord-001859-d62iuk72	560	47	puromycin	puromycin	NNS
cord-001859-d62iuk72	560	48	resistance	resistance	NN
cord-001859-d62iuk72	560	49	and	and	CC
cord-001859-d62iuk72	560	50	GFP	GFP	NNP
cord-001859-d62iuk72	560	51	gene	gene	NN
cord-001859-d62iuk72	560	52	,	,	,
cord-001859-d62iuk72	560	53	and	and	CC
cord-001859-d62iuk72	560	54	an	an	DT
cord-001859-d62iuk72	560	55	RFP	RFP	NNP
cord-001859-d62iuk72	560	56	gene	gene	NN
cord-001859-d62iuk72	560	57	that	that	WDT
cord-001859-d62iuk72	560	58	is	be	VBZ
cord-001859-d62iuk72	560	59	fused	fuse	VBN
cord-001859-d62iuk72	560	60	to	to	IN
cord-001859-d62iuk72	560	61	an	an	DT
cord-001859-d62iuk72	560	62	RTA	RTA	NNP
cord-001859-d62iuk72	560	63	-	-	HYPH
cord-001859-d62iuk72	560	64	responsive	responsive	JJ
cord-001859-d62iuk72	560	65	lytic	lytic	JJ
cord-001859-d62iuk72	560	66	cycle	cycle	NN
cord-001859-d62iuk72	560	67	(	(	-LRB-
cord-001859-d62iuk72	560	68	PAN	PAN	NNP
cord-001859-d62iuk72	560	69	)	)	-RRB-
cord-001859-d62iuk72	560	70	promoter	promoter	NN
cord-001859-d62iuk72	560	71	;	;	:
cord-001859-d62iuk72	560	72	hence	hence	RB
cord-001859-d62iuk72	560	73	,	,	,
cord-001859-d62iuk72	560	74	expression	expression	NN
cord-001859-d62iuk72	560	75	of	of	IN
cord-001859-d62iuk72	560	76	RFP	RFP	NNP
cord-001859-d62iuk72	560	77	can	can	MD
cord-001859-d62iuk72	560	78	be	be	VB
cord-001859-d62iuk72	560	79	used	use	VBN
cord-001859-d62iuk72	560	80	as	as	IN
cord-001859-d62iuk72	560	81	a	a	DT
cord-001859-d62iuk72	560	82	reporter	reporter	NN
cord-001859-d62iuk72	560	83	of	of	IN
cord-001859-d62iuk72	560	84	RTA	RTA	NNP
cord-001859-d62iuk72	560	85	activity	activity	NN
cord-001859-d62iuk72	560	86	[	[	-LRB-
cord-001859-d62iuk72	560	87	42	42	CD
cord-001859-d62iuk72	560	88	]	]	-RRB-
cord-001859-d62iuk72	560	89	.	.	.
cord-001859-d62iuk72	561	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	562	1	T	T	NNP
cord-001859-d62iuk72	562	2	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	562	3	cells	cell	NNS
cord-001859-d62iuk72	562	4	were	be	VBD
cord-001859-d62iuk72	562	5	grown	grow	VBN
cord-001859-d62iuk72	562	6	in	in	IN
cord-001859-d62iuk72	562	7	DMEM	DMEM	NNP
cord-001859-d62iuk72	562	8	(	(	-LRB-
cord-001859-d62iuk72	562	9	Life	Life	NNP
cord-001859-d62iuk72	562	10	Technologies	Technologies	NNPS
cord-001859-d62iuk72	562	11	)	)	-RRB-
cord-001859-d62iuk72	562	12	supplemented	supplement	VBD
cord-001859-d62iuk72	562	13	with	with	IN
cord-001859-d62iuk72	562	14	10	10	CD
cord-001859-d62iuk72	562	15	%	%	NN
cord-001859-d62iuk72	562	16	foetal	foetal	JJ
cord-001859-d62iuk72	562	17	calf	calf	NN
cord-001859-d62iuk72	562	18	serum	serum	NN
cord-001859-d62iuk72	562	19	(	(	-LRB-
cord-001859-d62iuk72	562	20	FCS	FCS	NNP
cord-001859-d62iuk72	562	21	)	)	-RRB-
cord-001859-d62iuk72	562	22	(	(	-LRB-
cord-001859-d62iuk72	562	23	Life	Life	NNP
cord-001859-d62iuk72	562	24	Technologies	Technologies	NNPS
cord-001859-d62iuk72	562	25	)	)	-RRB-
cord-001859-d62iuk72	562	26	and	and	CC
cord-001859-d62iuk72	562	27	1	1	CD
cord-001859-d62iuk72	562	28	%	%	NN
cord-001859-d62iuk72	562	29	penicillin	penicillin	NN
cord-001859-d62iuk72	562	30	/	/	SYM
cord-001859-d62iuk72	562	31	streptomycin	streptomycin	NN
cord-001859-d62iuk72	562	32	(	(	-LRB-
cord-001859-d62iuk72	562	33	P	p	NN
cord-001859-d62iuk72	562	34	/	/	SYM
cord-001859-d62iuk72	562	35	S	S	NNP
cord-001859-d62iuk72	562	36	)	)	-RRB-
cord-001859-d62iuk72	562	37	.	.	.
cord-001859-d62iuk72	563	1	This	this	DT
cord-001859-d62iuk72	563	2	cell	cell	NN
cord-001859-d62iuk72	563	3	line	line	NN
cord-001859-d62iuk72	563	4	was	be	VBD
cord-001859-d62iuk72	563	5	kept	keep	VBN
cord-001859-d62iuk72	563	6	under	under	IN
cord-001859-d62iuk72	563	7	puromycin	puromycin	NNS
cord-001859-d62iuk72	563	8	(	(	-LRB-
cord-001859-d62iuk72	563	9	Sigma	Sigma	NNP
cord-001859-d62iuk72	563	10	)	)	-RRB-
cord-001859-d62iuk72	563	11	selection	selection	NN
cord-001859-d62iuk72	563	12	(	(	-LRB-
cord-001859-d62iuk72	563	13	0.2	0.2	CD
cord-001859-d62iuk72	563	14	μg	μg	NN
cord-001859-d62iuk72	563	15	/	/	SYM
cord-001859-d62iuk72	563	16	ml	ml	NNP
cord-001859-d62iuk72	563	17	)	)	-RRB-
cord-001859-d62iuk72	563	18	.	.	.
cord-001859-d62iuk72	564	1	Reactivation	reactivation	NN
cord-001859-d62iuk72	564	2	into	into	IN
cord-001859-d62iuk72	564	3	the	the	DT
cord-001859-d62iuk72	564	4	lytic	lytic	JJ
cord-001859-d62iuk72	564	5	cycle	cycle	NN
cord-001859-d62iuk72	564	6	was	be	VBD
cord-001859-d62iuk72	564	7	achieved	achieve	VBN
cord-001859-d62iuk72	564	8	by	by	IN
cord-001859-d62iuk72	564	9	addition	addition	NN
cord-001859-d62iuk72	564	10	of	of	IN
cord-001859-d62iuk72	564	11	12-O	12-o	JJ
cord-001859-d62iuk72	564	12	-	-	HYPH
cord-001859-d62iuk72	564	13	tetradecanoylphorbol	tetradecanoylphorbol	NNP
cord-001859-d62iuk72	564	14	13-acetate	13-acetate	CD
cord-001859-d62iuk72	564	15	(	(	-LRB-
cord-001859-d62iuk72	564	16	TPA	TPA	NNP
cord-001859-d62iuk72	564	17	)	)	-RRB-
cord-001859-d62iuk72	564	18	(	(	-LRB-
cord-001859-d62iuk72	564	19	20	20	CD
cord-001859-d62iuk72	564	20	ng	ng	NN
cord-001859-d62iuk72	564	21	/	/	SYM
cord-001859-d62iuk72	564	22	ml	ml	NN
cord-001859-d62iuk72	564	23	)	)	-RRB-
cord-001859-d62iuk72	564	24	and	and	CC
cord-001859-d62iuk72	564	25	sodium	sodium	NN
cord-001859-d62iuk72	564	26	n	n	NN
cord-001859-d62iuk72	564	27	-	-	HYPH
cord-001859-d62iuk72	564	28	butyrate	butyrate	NNP
cord-001859-d62iuk72	564	29	(	(	-LRB-
cord-001859-d62iuk72	564	30	NaB	NaB	NNP
cord-001859-d62iuk72	564	31	)	)	-RRB-
cord-001859-d62iuk72	565	1	(	(	-LRB-
cord-001859-d62iuk72	565	2	Sigma	Sigma	NNP
cord-001859-d62iuk72	565	3	)	)	-RRB-
cord-001859-d62iuk72	565	4	(	(	-LRB-
cord-001859-d62iuk72	565	5	4	4	CD
cord-001859-d62iuk72	565	6	mM	mm	CD
cord-001859-d62iuk72	565	7	)	)	-RRB-
cord-001859-d62iuk72	565	8	.	.	.
cord-001859-d62iuk72	566	1	The	the	DT
cord-001859-d62iuk72	566	2	TREx	TREx	NNS
cord-001859-d62iuk72	566	3	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	566	4	cell	cell	NN
cord-001859-d62iuk72	566	5	line	line	NN
cord-001859-d62iuk72	566	6	was	be	VBD
cord-001859-d62iuk72	566	7	grown	grow	VBN
cord-001859-d62iuk72	566	8	in	in	IN
cord-001859-d62iuk72	566	9	RPMI	RPMI	NNP
cord-001859-d62iuk72	566	10	1640	1640	CD
cord-001859-d62iuk72	566	11	medium	medium	NN
cord-001859-d62iuk72	566	12	(	(	-LRB-
cord-001859-d62iuk72	566	13	Life	Life	NNP
cord-001859-d62iuk72	566	14	Technologies	Technologies	NNPS
cord-001859-d62iuk72	566	15	)	)	-RRB-
cord-001859-d62iuk72	566	16	supplemented	supplement	VBD
cord-001859-d62iuk72	566	17	with	with	IN
cord-001859-d62iuk72	566	18	10	10	CD
cord-001859-d62iuk72	566	19	%	%	NN
cord-001859-d62iuk72	566	20	FCS	FCS	NNP
cord-001859-d62iuk72	566	21	and	and	CC
cord-001859-d62iuk72	566	22	1	1	CD
cord-001859-d62iuk72	566	23	%	%	NN
cord-001859-d62iuk72	566	24	P	p	NN
cord-001859-d62iuk72	566	25	/	/	SYM
cord-001859-d62iuk72	566	26	S.	S.	NNP
cord-001859-d62iuk72	567	1	This	this	DT
cord-001859-d62iuk72	567	2	cell	cell	NN
cord-001859-d62iuk72	567	3	line	line	NN
cord-001859-d62iuk72	567	4	was	be	VBD
cord-001859-d62iuk72	567	5	kept	keep	VBN
cord-001859-d62iuk72	567	6	under	under	IN
cord-001859-d62iuk72	567	7	hygromycin	hygromycin	NNS
cord-001859-d62iuk72	567	8	B	B	NNP
cord-001859-d62iuk72	567	9	(	(	-LRB-
cord-001859-d62iuk72	567	10	Life	Life	NNP
cord-001859-d62iuk72	567	11	Technologies	Technologies	NNPS
cord-001859-d62iuk72	567	12	)	)	-RRB-
cord-001859-d62iuk72	567	13	selection	selection	NN
cord-001859-d62iuk72	567	14	(	(	-LRB-
cord-001859-d62iuk72	567	15	100	100	CD
cord-001859-d62iuk72	567	16	μg	μg	NN
cord-001859-d62iuk72	567	17	/	/	SYM
cord-001859-d62iuk72	567	18	ml	ml	NN
cord-001859-d62iuk72	567	19	)	)	-RRB-
cord-001859-d62iuk72	567	20	and	and	CC
cord-001859-d62iuk72	567	21	inductions	induction	NNS
cord-001859-d62iuk72	567	22	were	be	VBD
cord-001859-d62iuk72	567	23	performed	perform	VBN
cord-001859-d62iuk72	567	24	using	use	VBG
cord-001859-d62iuk72	567	25	2	2	CD
cord-001859-d62iuk72	568	1	μg	μg	NNP
cord-001859-d62iuk72	568	2	/	/	SYM
cord-001859-d62iuk72	568	3	ml	ml	FW
cord-001859-d62iuk72	568	4	doxycycline	doxycycline	NNP
cord-001859-d62iuk72	568	5	hyclate	hyclate	NNP
cord-001859-d62iuk72	568	6	(	(	-LRB-
cord-001859-d62iuk72	568	7	Sigma	Sigma	NNP
cord-001859-d62iuk72	568	8	)	)	-RRB-
cord-001859-d62iuk72	569	1	as	as	IN
cord-001859-d62iuk72	569	2	previously	previously	RB
cord-001859-d62iuk72	569	3	described	describe	VBN
cord-001859-d62iuk72	569	4	[	[	-LRB-
cord-001859-d62iuk72	569	5	98	98	CD
cord-001859-d62iuk72	569	6	]	]	-RRB-
cord-001859-d62iuk72	569	7	.	.	.
cord-001859-d62iuk72	570	1	All	all	DT
cord-001859-d62iuk72	570	2	cells	cell	NNS
cord-001859-d62iuk72	570	3	were	be	VBD
cord-001859-d62iuk72	570	4	maintained	maintain	VBN
cord-001859-d62iuk72	570	5	at	at	IN
cord-001859-d62iuk72	570	6	37	37	CD
cord-001859-d62iuk72	570	7	°	°	NN
cord-001859-d62iuk72	570	8	C	c	NN
cord-001859-d62iuk72	570	9	in	in	IN
cord-001859-d62iuk72	570	10	a	a	DT
cord-001859-d62iuk72	570	11	humidified	humidify	VBN
cord-001859-d62iuk72	570	12	incubator	incubator	NN
cord-001859-d62iuk72	570	13	with	with	IN
cord-001859-d62iuk72	570	14	5	5	CD
cord-001859-d62iuk72	570	15	%	%	NN
cord-001859-d62iuk72	570	16	CO	co	NN
cord-001859-d62iuk72	570	17	2	2	CD
cord-001859-d62iuk72	570	18	.	.	.
cord-001859-d62iuk72	571	1	Plasmid	Plasmid	NNP
cord-001859-d62iuk72	571	2	transfections	transfection	NNS
cord-001859-d62iuk72	571	3	were	be	VBD
cord-001859-d62iuk72	571	4	carried	carry	VBN
cord-001859-d62iuk72	571	5	out	out	RP
cord-001859-d62iuk72	571	6	using	use	VBG
cord-001859-d62iuk72	571	7	Lipofectamine	Lipofectamine	NNP
cord-001859-d62iuk72	571	8	2000	2000	CD
cord-001859-d62iuk72	571	9	(	(	-LRB-
cord-001859-d62iuk72	571	10	Life	Life	NNP
cord-001859-d62iuk72	571	11	Technologies	Technologies	NNPS
cord-001859-d62iuk72	571	12	)	)	-RRB-
cord-001859-d62iuk72	571	13	,	,	,
cord-001859-d62iuk72	571	14	as	as	IN
cord-001859-d62iuk72	571	15	previously	previously	RB
cord-001859-d62iuk72	571	16	described	describe	VBN
cord-001859-d62iuk72	571	17	[	[	-LRB-
cord-001859-d62iuk72	571	18	99	99	CD
cord-001859-d62iuk72	571	19	]	]	-RRB-
cord-001859-d62iuk72	571	20	.	.	.
cord-001859-d62iuk72	572	1	Luciferase	luciferase	NN
cord-001859-d62iuk72	572	2	assay	assay	NN
cord-001859-d62iuk72	572	3	plasmids	plasmid	NNS
cord-001859-d62iuk72	572	4	Renilla	Renilla	NNP
cord-001859-d62iuk72	572	5	luciferase	luciferase	NN
cord-001859-d62iuk72	572	6	vector	vector	NN
cord-001859-d62iuk72	572	7	pRL	pRL	NNP
cord-001859-d62iuk72	572	8	-	-	HYPH
cord-001859-d62iuk72	572	9	TK	tk	NN
cord-001859-d62iuk72	572	10	and	and	CC
cord-001859-d62iuk72	572	11	firefly	firefly	NN
cord-001859-d62iuk72	572	12	luciferase	luciferase	NN
cord-001859-d62iuk72	572	13	vector	vector	NNP
cord-001859-d62iuk72	573	1	pGL3-BASIC	pGL3-BASIC	NNP
cord-001859-d62iuk72	573	2	were	be	VBD
cord-001859-d62iuk72	573	3	purchased	purchase	VBN
cord-001859-d62iuk72	573	4	from	from	IN
cord-001859-d62iuk72	573	5	Promega	Promega	NNP
cord-001859-d62iuk72	573	6	,	,	,
cord-001859-d62iuk72	573	7	pEGFP	pEGFP	NNP
cord-001859-d62iuk72	573	8	-	-	HYPH
cord-001859-d62iuk72	573	9	N1	N1	NNP
cord-001859-d62iuk72	573	10	was	be	VBD
cord-001859-d62iuk72	573	11	obtained	obtain	VBN
cord-001859-d62iuk72	573	12	from	from	IN
cord-001859-d62iuk72	573	13	Clontech	Clontech	NNP
cord-001859-d62iuk72	573	14	,	,	,
cord-001859-d62iuk72	573	15	pRTA	prta	JJ
cord-001859-d62iuk72	573	16	-	-	:
cord-001859-d62iuk72	573	17	EGFP	EGFP	NNP
cord-001859-d62iuk72	573	18	and	and	CC
cord-001859-d62iuk72	573	19	pPAN	pPAN	NNP
cord-001859-d62iuk72	573	20	-	-	HYPH
cord-001859-d62iuk72	573	21	WT	WT	NNP
cord-001859-d62iuk72	573	22	have	have	VBP
cord-001859-d62iuk72	573	23	been	be	VBN
cord-001859-d62iuk72	573	24	previously	previously	RB
cord-001859-d62iuk72	573	25	described	describe	VBN
cord-001859-d62iuk72	573	26	[	[	-LRB-
cord-001859-d62iuk72	573	27	71	71	CD
cord-001859-d62iuk72	573	28	,	,	,
cord-001859-d62iuk72	573	29	100	100	CD
cord-001859-d62iuk72	573	30	]	]	-RRB-
cord-001859-d62iuk72	573	31	.	.	.
cord-001859-d62iuk72	574	1	The	the	DT
cord-001859-d62iuk72	574	2	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	574	3	mouse	mouse	NN
cord-001859-d62iuk72	574	4	antibodies	antibody	NNS
cord-001859-d62iuk72	574	5	to	to	IN
cord-001859-d62iuk72	574	6	anti	anti	JJ
cord-001859-d62iuk72	574	7	-	-	JJ
cord-001859-d62iuk72	574	8	nuclear	nuclear	JJ
cord-001859-d62iuk72	574	9	pore	pore	NN
cord-001859-d62iuk72	574	10	complex	complex	NN
cord-001859-d62iuk72	574	11	proteins	protein	NNS
cord-001859-d62iuk72	575	1	(	(	-LRB-
cord-001859-d62iuk72	575	2	mAb414	mAb414	NNP
cord-001859-d62iuk72	575	3	)	)	-RRB-
cord-001859-d62iuk72	575	4	(	(	-LRB-
cord-001859-d62iuk72	575	5	ab24609	ab24609	NNP
cord-001859-d62iuk72	575	6	)	)	-RRB-
cord-001859-d62iuk72	575	7	,	,	,
cord-001859-d62iuk72	575	8	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	575	9	(	(	-LRB-
cord-001859-d62iuk72	575	10	6C5	6c5	CD
cord-001859-d62iuk72	575	11	)	)	-RRB-
cord-001859-d62iuk72	575	12	,	,	,
cord-001859-d62iuk72	575	13	rabbit	rabbit	NN
cord-001859-d62iuk72	575	14	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	575	15	anti	anti	JJ
cord-001859-d62iuk72	575	16	-	-	JJ
cord-001859-d62iuk72	575	17	lamin	lamin	JJ
cord-001859-d62iuk72	575	18	B1	b1	NN
cord-001859-d62iuk72	575	19	and	and	CC
cord-001859-d62iuk72	575	20	anti	anti	JJ
cord-001859-d62iuk72	575	21	-	-	JJ
cord-001859-d62iuk72	575	22	Ser2	ser2	JJ
cord-001859-d62iuk72	575	23	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	575	24	were	be	VBD
cord-001859-d62iuk72	575	25	purchased	purchase	VBN
cord-001859-d62iuk72	575	26	from	from	IN
cord-001859-d62iuk72	575	27	Abcam	Abcam	NNP
cord-001859-d62iuk72	575	28	.	.	.
cord-001859-d62iuk72	576	1	The	the	DT
cord-001859-d62iuk72	576	2	rabbit	rabbit	NN
cord-001859-d62iuk72	576	3	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	576	4	anti	anti	JJ
cord-001859-d62iuk72	576	5	-	-	JJ
cord-001859-d62iuk72	576	6	histone	histone	JJ
cord-001859-d62iuk72	576	7	H3	H3	NNP
cord-001859-d62iuk72	576	8	C	c	NN
cord-001859-d62iuk72	576	9	-	-	HYPH
cord-001859-d62iuk72	576	10	terminus	terminus	NN
cord-001859-d62iuk72	576	11	(	(	-LRB-
cord-001859-d62iuk72	576	12	39164	39164	CD
cord-001859-d62iuk72	576	13	)	)	-RRB-
cord-001859-d62iuk72	576	14	was	be	VBD
cord-001859-d62iuk72	576	15	purchased	purchase	VBN
cord-001859-d62iuk72	576	16	from	from	IN
cord-001859-d62iuk72	576	17	Active	active	JJ
cord-001859-d62iuk72	576	18	Motif	Motif	NNP
cord-001859-d62iuk72	576	19	.	.	.
cord-001859-d62iuk72	577	1	The	the	DT
cord-001859-d62iuk72	577	2	rabbit	rabbit	NN
cord-001859-d62iuk72	577	3	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	577	4	anti	anti	NNP
cord-001859-d62iuk72	577	5	-	-	NNP
cord-001859-d62iuk72	577	6	Nup160	Nup160	NNP
cord-001859-d62iuk72	577	7	was	be	VBD
cord-001859-d62iuk72	577	8	obtained	obtain	VBN
cord-001859-d62iuk72	577	9	from	from	IN
cord-001859-d62iuk72	577	10	Bethyl	Bethyl	NNP
cord-001859-d62iuk72	577	11	Laboratories	Laboratories	NNP
cord-001859-d62iuk72	577	12	.	.	.
cord-001859-d62iuk72	578	1	Monoclonal	monoclonal	JJ
cord-001859-d62iuk72	578	2	antibodies	antibody	NNS
cord-001859-d62iuk72	578	3	to	to	IN
cord-001859-d62iuk72	578	4	KSHV	KSHV	NNP
cord-001859-d62iuk72	579	1	ORF57	ORF57	NNP
cord-001859-d62iuk72	580	1	(	(	-LRB-
cord-001859-d62iuk72	580	2	207.6	207.6	CD
cord-001859-d62iuk72	580	3	)	)	-RRB-
cord-001859-d62iuk72	580	4	,	,	,
cord-001859-d62iuk72	580	5	to	to	IN
cord-001859-d62iuk72	580	6	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	580	7	(	(	-LRB-
cord-001859-d62iuk72	580	8	B-6	B-6	NNP
cord-001859-d62iuk72	580	9	)	)	-RRB-
cord-001859-d62iuk72	580	10	,	,	,
cord-001859-d62iuk72	580	11	to	to	IN
cord-001859-d62iuk72	580	12	Grp78	Grp78	NNP
cord-001859-d62iuk72	580	13	(	(	-LRB-
cord-001859-d62iuk72	580	14	A-10	A-10	NNP
cord-001859-d62iuk72	580	15	)	)	-RRB-
cord-001859-d62iuk72	580	16	,	,	,
cord-001859-d62iuk72	580	17	to	to	IN
cord-001859-d62iuk72	580	18	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	580	19	(	(	-LRB-
cord-001859-d62iuk72	580	20	4F10	4f10	CD
cord-001859-d62iuk72	580	21	)	)	-RRB-
cord-001859-d62iuk72	580	22	,	,	,
cord-001859-d62iuk72	580	23	to	to	IN
cord-001859-d62iuk72	580	24	B-23	B-23	NNP
cord-001859-d62iuk72	580	25	(	(	-LRB-
cord-001859-d62iuk72	580	26	0412	0412	CD
cord-001859-d62iuk72	580	27	)	)	-RRB-
cord-001859-d62iuk72	580	28	and	and	CC
cord-001859-d62iuk72	580	29	to	to	IN
cord-001859-d62iuk72	580	30	C-23	C-23	NNP
cord-001859-d62iuk72	580	31	(	(	-LRB-
cord-001859-d62iuk72	580	32	H6	H6	NNP
cord-001859-d62iuk72	580	33	)	)	-RRB-
cord-001859-d62iuk72	580	34	were	be	VBD
cord-001859-d62iuk72	580	35	obtained	obtain	VBN
cord-001859-d62iuk72	580	36	from	from	IN
cord-001859-d62iuk72	580	37	Santa	Santa	NNP
cord-001859-d62iuk72	580	38	Cruz	Cruz	NNP
cord-001859-d62iuk72	580	39	.	.	.
cord-001859-d62iuk72	581	1	The	the	DT
cord-001859-d62iuk72	581	2	mouse	mouse	NN
cord-001859-d62iuk72	581	3	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	581	4	(	(	-LRB-
cord-001859-d62iuk72	581	5	C92F3A-5	C92F3A-5	NNP
cord-001859-d62iuk72	581	6	)	)	-RRB-
cord-001859-d62iuk72	581	7	anti	anti	NNS
cord-001859-d62iuk72	581	8	-	-	NN
cord-001859-d62iuk72	581	9	iHsp70	ihsp70	JJ
cord-001859-d62iuk72	581	10	was	be	VBD
cord-001859-d62iuk72	581	11	from	from	IN
cord-001859-d62iuk72	581	12	Enzo	Enzo	NNP
cord-001859-d62iuk72	581	13	Life	Life	NNP
cord-001859-d62iuk72	581	14	Sciences	Sciences	NNPS
cord-001859-d62iuk72	581	15	.	.	.
cord-001859-d62iuk72	582	1	The	the	DT
cord-001859-d62iuk72	582	2	rabbit	rabbit	NN
cord-001859-d62iuk72	582	3	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	582	4	anti	anti	NNP
cord-001859-d62iuk72	582	5	-	-	NNP
cord-001859-d62iuk72	582	6	PARP1	PARP1	NNP
cord-001859-d62iuk72	582	7	was	be	VBD
cord-001859-d62iuk72	582	8	purchased	purchase	VBN
cord-001859-d62iuk72	582	9	from	from	IN
cord-001859-d62iuk72	582	10	Cell	Cell	NNP
cord-001859-d62iuk72	582	11	Signalling	Signalling	NNP
cord-001859-d62iuk72	582	12	.	.	.
cord-001859-d62iuk72	583	1	The	the	DT
cord-001859-d62iuk72	583	2	mouse	mouse	NN
cord-001859-d62iuk72	583	3	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	583	4	(	(	-LRB-
cord-001859-d62iuk72	583	5	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	583	6	)	)	-RRB-
cord-001859-d62iuk72	583	7	anti	anti	JJ
cord-001859-d62iuk72	583	8	-	-	NNP
cord-001859-d62iuk72	583	9	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	583	10	was	be	VBD
cord-001859-d62iuk72	583	11	purchased	purchase	VBN
cord-001859-d62iuk72	583	12	from	from	IN
cord-001859-d62iuk72	583	13	Millipore	Millipore	NNP
cord-001859-d62iuk72	583	14	.	.	.
cord-001859-d62iuk72	584	1	The	the	DT
cord-001859-d62iuk72	584	2	mouse	mouse	NN
cord-001859-d62iuk72	584	3	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	584	4	(	(	-LRB-
cord-001859-d62iuk72	584	5	9E10	9e10	CD
cord-001859-d62iuk72	584	6	)	)	-RRB-
cord-001859-d62iuk72	584	7	anti	anti	JJ
cord-001859-d62iuk72	584	8	-	-	JJ
cord-001859-d62iuk72	584	9	c	c	JJ
cord-001859-d62iuk72	584	10	-	-	HYPH
cord-001859-d62iuk72	584	11	Myc	Myc	NNP
cord-001859-d62iuk72	584	12	was	be	VBD
cord-001859-d62iuk72	584	13	from	from	IN
cord-001859-d62iuk72	584	14	Sigma	Sigma	NNP
cord-001859-d62iuk72	584	15	.	.	.
cord-001859-d62iuk72	585	1	Sheep	Sheep	NNP
cord-001859-d62iuk72	585	2	anti	anti	JJ
cord-001859-d62iuk72	585	3	-	-	JJ
cord-001859-d62iuk72	585	4	KSHV	kshv	JJ
cord-001859-d62iuk72	585	5	minor	minor	JJ
cord-001859-d62iuk72	585	6	capsid	capsid	NN
cord-001859-d62iuk72	585	7	protein	protein	NN
cord-001859-d62iuk72	585	8	was	be	VBD
cord-001859-d62iuk72	585	9	purchased	purchase	VBN
cord-001859-d62iuk72	585	10	from	from	IN
cord-001859-d62iuk72	585	11	Exalpha	Exalpha	NNP
cord-001859-d62iuk72	585	12	Biologicals	Biologicals	NNP
cord-001859-d62iuk72	585	13	,	,	,
cord-001859-d62iuk72	586	1	Inc.	Inc.	NNP
cord-001859-d62iuk72	586	2	The	the	DT
cord-001859-d62iuk72	586	3	rabbit	rabbit	NN
cord-001859-d62iuk72	586	4	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	586	5	anti	anti	NNP
cord-001859-d62iuk72	586	6	-	-	NNP
cord-001859-d62iuk72	586	7	RTA	RTA	NNP
cord-001859-d62iuk72	586	8	was	be	VBD
cord-001859-d62iuk72	586	9	a	a	DT
cord-001859-d62iuk72	586	10	gift	gift	NN
cord-001859-d62iuk72	586	11	from	from	IN
cord-001859-d62iuk72	586	12	Professor	Professor	NNP
cord-001859-d62iuk72	586	13	David	David	NNP
cord-001859-d62iuk72	586	14	Blackbourn	Blackbourn	NNP
cord-001859-d62iuk72	586	15	(	(	-LRB-
cord-001859-d62iuk72	586	16	University	University	NNP
cord-001859-d62iuk72	586	17	of	of	IN
cord-001859-d62iuk72	586	18	Surrey	Surrey	NNP
cord-001859-d62iuk72	586	19	,	,	,
cord-001859-d62iuk72	586	20	UK	UK	NNP
cord-001859-d62iuk72	586	21	)	)	-RRB-
cord-001859-d62iuk72	586	22	.	.	.
cord-001859-d62iuk72	587	1	The	the	DT
cord-001859-d62iuk72	587	2	mouse	mouse	NN
cord-001859-d62iuk72	587	3	monoclonal	monoclonal	JJ
cord-001859-d62iuk72	587	4	(	(	-LRB-
cord-001859-d62iuk72	587	5	JL-8	JL-8	NNP
cord-001859-d62iuk72	587	6	)	)	-RRB-
cord-001859-d62iuk72	588	1	anti	anti	JJ
cord-001859-d62iuk72	588	2	-	-	NNP
cord-001859-d62iuk72	588	3	GFP	GFP	NNP
cord-001859-d62iuk72	588	4	was	be	VBD
cord-001859-d62iuk72	588	5	supplied	supply	VBN
cord-001859-d62iuk72	588	6	by	by	IN
cord-001859-d62iuk72	588	7	Clontech	Clontech	NNP
cord-001859-d62iuk72	588	8	.	.	.
cord-001859-d62iuk72	589	1	The	the	DT
cord-001859-d62iuk72	589	2	inhibitor	inhibitor	NN
cord-001859-d62iuk72	589	3	for	for	IN
cord-001859-d62iuk72	589	4	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	589	5	isoforms	isoform	NNS
cord-001859-d62iuk72	589	6	(	(	-LRB-
cord-001859-d62iuk72	589	7	VER-155008	ver-155008	NN
cord-001859-d62iuk72	589	8	)	)	-RRB-
cord-001859-d62iuk72	589	9	was	be	VBD
cord-001859-d62iuk72	589	10	obtained	obtain	VBN
cord-001859-d62iuk72	589	11	from	from	IN
cord-001859-d62iuk72	589	12	Tocris	Tocris	NNP
cord-001859-d62iuk72	589	13	Bioscience	Bioscience	NNP
cord-001859-d62iuk72	589	14	.	.	.
cord-001859-d62iuk72	590	1	For	for	IN
cord-001859-d62iuk72	590	2	SILAC	SILAC	NNP
cord-001859-d62iuk72	590	3	,	,	,
cord-001859-d62iuk72	590	4	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	590	5	T	t	NN
cord-001859-d62iuk72	590	6	cells	cell	NNS
cord-001859-d62iuk72	590	7	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	590	8	were	be	VBD
cord-001859-d62iuk72	590	9	fed	feed	VBN
cord-001859-d62iuk72	590	10	with	with	IN
cord-001859-d62iuk72	590	11	either	either	DT
cord-001859-d62iuk72	590	12	medium	medium	NN
cord-001859-d62iuk72	590	13	(	(	-LRB-
cord-001859-d62iuk72	590	14	R6K4	R6K4	NNP
cord-001859-d62iuk72	590	15	)	)	-RRB-
cord-001859-d62iuk72	590	16	or	or	CC
cord-001859-d62iuk72	590	17	light	light	NN
cord-001859-d62iuk72	590	18	(	(	-LRB-
cord-001859-d62iuk72	590	19	R0K0	R0K0	NNP
cord-001859-d62iuk72	590	20	)	)	-RRB-
cord-001859-d62iuk72	590	21	labelled	label	VBN
cord-001859-d62iuk72	590	22	medium	medium	NN
cord-001859-d62iuk72	590	23	(	(	-LRB-
cord-001859-d62iuk72	590	24	Dundee	Dundee	NNP
cord-001859-d62iuk72	590	25	Cell	Cell	NNP
cord-001859-d62iuk72	590	26	Products	Products	NNPS
cord-001859-d62iuk72	590	27	)	)	-RRB-
cord-001859-d62iuk72	590	28	containing	contain	VBG
cord-001859-d62iuk72	590	29	10	10	CD
cord-001859-d62iuk72	590	30	%	%	NN
cord-001859-d62iuk72	590	31	dialysed	dialyse	VBD
cord-001859-d62iuk72	590	32	FCS	FCS	NNP
cord-001859-d62iuk72	590	33	(	(	-LRB-
cord-001859-d62iuk72	590	34	Dundee	Dundee	NNP
cord-001859-d62iuk72	590	35	Cell	Cell	NNP
cord-001859-d62iuk72	590	36	Products	Products	NNPS
cord-001859-d62iuk72	590	37	)	)	-RRB-
cord-001859-d62iuk72	590	38	for	for	IN
cord-001859-d62iuk72	590	39	six	six	CD
cord-001859-d62iuk72	590	40	passages	passage	NNS
cord-001859-d62iuk72	590	41	to	to	TO
cord-001859-d62iuk72	590	42	allow	allow	VB
cord-001859-d62iuk72	590	43	incorporation	incorporation	NN
cord-001859-d62iuk72	590	44	of	of	IN
cord-001859-d62iuk72	590	45	the	the	DT
cord-001859-d62iuk72	590	46	isotopes	isotope	NNS
cord-001859-d62iuk72	590	47	,	,	,
cord-001859-d62iuk72	590	48	as	as	IN
cord-001859-d62iuk72	590	49	previously	previously	RB
cord-001859-d62iuk72	590	50	described	describe	VBN
cord-001859-d62iuk72	590	51	[	[	-LRB-
cord-001859-d62iuk72	590	52	101	101	CD
cord-001859-d62iuk72	590	53	]	]	-RRB-
cord-001859-d62iuk72	590	54	.	.	.
cord-001859-d62iuk72	591	1	Subsequently	subsequently	RB
cord-001859-d62iuk72	591	2	,	,	,
cord-001859-d62iuk72	591	3	to	to	TO
cord-001859-d62iuk72	591	4	induce	induce	VB
cord-001859-d62iuk72	591	5	lytic	lytic	JJ
cord-001859-d62iuk72	591	6	replication	replication	NN
cord-001859-d62iuk72	591	7	three	three	CD
cord-001859-d62iuk72	591	8	T175	t175	CD
cord-001859-d62iuk72	591	9	flasks	flask	NNS
cord-001859-d62iuk72	591	10	were	be	VBD
cord-001859-d62iuk72	591	11	reactivated	reactivate	VBN
cord-001859-d62iuk72	591	12	with	with	IN
cord-001859-d62iuk72	591	13	TPA	TPA	NNP
cord-001859-d62iuk72	591	14	(	(	-LRB-
cord-001859-d62iuk72	591	15	20	20	CD
cord-001859-d62iuk72	591	16	ng	ng	NN
cord-001859-d62iuk72	591	17	/	/	SYM
cord-001859-d62iuk72	591	18	ml	ml	NN
cord-001859-d62iuk72	591	19	)	)	-RRB-
cord-001859-d62iuk72	591	20	and	and	CC
cord-001859-d62iuk72	591	21	NaB	NaB	NNP
cord-001859-d62iuk72	591	22	(	(	-LRB-
cord-001859-d62iuk72	591	23	4mM	4mm	CD
cord-001859-d62iuk72	591	24	)	)	-RRB-
cord-001859-d62iuk72	591	25	for	for	IN
cord-001859-d62iuk72	591	26	48	48	CD
cord-001859-d62iuk72	591	27	h	h	NN
cord-001859-d62iuk72	591	28	,	,	,
cord-001859-d62iuk72	591	29	while	while	IN
cord-001859-d62iuk72	591	30	another	another	DT
cord-001859-d62iuk72	591	31	three	three	CD
cord-001859-d62iuk72	591	32	T175	T175	NNP
cord-001859-d62iuk72	591	33	flasks	flask	NNS
cord-001859-d62iuk72	591	34	remained	remain	VBD
cord-001859-d62iuk72	591	35	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	591	36	as	as	IN
cord-001859-d62iuk72	591	37	control	control	NN
cord-001859-d62iuk72	591	38	.	.	.
cord-001859-d62iuk72	592	1	To	to	TO
cord-001859-d62iuk72	592	2	isolate	isolate	VB
cord-001859-d62iuk72	592	3	NEs	ne	NNS
cord-001859-d62iuk72	592	4	a	a	DT
cord-001859-d62iuk72	592	5	protocol	protocol	NN
cord-001859-d62iuk72	592	6	published	publish	VBN
cord-001859-d62iuk72	592	7	by	by	IN
cord-001859-d62iuk72	592	8	Korfali	Korfali	NNP
cord-001859-d62iuk72	592	9	et	et	NNP
cord-001859-d62iuk72	592	10	al	al	NNP
cord-001859-d62iuk72	592	11	.	.	NNP
cord-001859-d62iuk72	592	12	,	,	,
cord-001859-d62iuk72	592	13	[	[	-LRB-
cord-001859-d62iuk72	592	14	35	35	CD
cord-001859-d62iuk72	592	15	]	]	-RRB-
cord-001859-d62iuk72	592	16	was	be	VBD
cord-001859-d62iuk72	592	17	used	use	VBN
cord-001859-d62iuk72	592	18	with	with	IN
cord-001859-d62iuk72	592	19	minor	minor	JJ
cord-001859-d62iuk72	592	20	modifications	modification	NNS
cord-001859-d62iuk72	592	21	.	.	.
cord-001859-d62iuk72	593	1	75	75	CD
cord-001859-d62iuk72	593	2	million	million	CD
cord-001859-d62iuk72	593	3	cells	cell	NNS
cord-001859-d62iuk72	593	4	were	be	VBD
cord-001859-d62iuk72	593	5	used	use	VBN
cord-001859-d62iuk72	593	6	per	per	IN
cord-001859-d62iuk72	593	7	experimental	experimental	JJ
cord-001859-d62iuk72	593	8	condition	condition	NN
cord-001859-d62iuk72	593	9	.	.	.
cord-001859-d62iuk72	594	1	Cells	cell	NNS
cord-001859-d62iuk72	594	2	were	be	VBD
cord-001859-d62iuk72	594	3	washed	wash	VBN
cord-001859-d62iuk72	594	4	with	with	IN
cord-001859-d62iuk72	594	5	PBS	PBS	NNP
cord-001859-d62iuk72	594	6	and	and	CC
cord-001859-d62iuk72	594	7	incubated	incubate	VBN
cord-001859-d62iuk72	594	8	in	in	IN
cord-001859-d62iuk72	594	9	hypotonic	hypotonic	JJ
cord-001859-d62iuk72	594	10	lysis	lysis	NN
cord-001859-d62iuk72	594	11	buffer	buffer	NN
cord-001859-d62iuk72	594	12	(	(	-LRB-
cord-001859-d62iuk72	594	13	10	10	CD
cord-001859-d62iuk72	594	14	mM	mm	CD
cord-001859-d62iuk72	594	15	HEPES	HEPES	NNP
cord-001859-d62iuk72	594	16	pH	pH	NNP
cord-001859-d62iuk72	594	17	7.4	7.4	CD
cord-001859-d62iuk72	594	18	,	,	,
cord-001859-d62iuk72	594	19	1.5	1.5	CD
cord-001859-d62iuk72	594	20	mM	mm	CD
cord-001859-d62iuk72	594	21	MgCl	MgCl	NNP
cord-001859-d62iuk72	594	22	2	2	CD
cord-001859-d62iuk72	594	23	,	,	,
cord-001859-d62iuk72	594	24	and	and	CC
cord-001859-d62iuk72	594	25	10	10	CD
cord-001859-d62iuk72	594	26	mM	mm	CD
cord-001859-d62iuk72	594	27	KCl	KCl	NNS
cord-001859-d62iuk72	594	28	)	)	-RRB-
cord-001859-d62iuk72	594	29	for	for	IN
cord-001859-d62iuk72	594	30	30	30	CD
cord-001859-d62iuk72	594	31	min	min	NN
cord-001859-d62iuk72	594	32	followed	follow	VBN
cord-001859-d62iuk72	594	33	by	by	IN
cord-001859-d62iuk72	594	34	homogenization	homogenization	NN
cord-001859-d62iuk72	594	35	with	with	IN
cord-001859-d62iuk72	594	36	a	a	DT
cord-001859-d62iuk72	594	37	tight	tight	JJ
cord-001859-d62iuk72	594	38	Dounce	Dounce	NNP
cord-001859-d62iuk72	594	39	homogenizer	homogenizer	NN
cord-001859-d62iuk72	594	40	.	.	.
cord-001859-d62iuk72	595	1	To	to	TO
cord-001859-d62iuk72	595	2	stabilise	stabilise	VB
cord-001859-d62iuk72	595	3	and	and	CC
cord-001859-d62iuk72	595	4	avoid	avoid	VB
cord-001859-d62iuk72	595	5	lysing	lyse	VBG
cord-001859-d62iuk72	595	6	the	the	DT
cord-001859-d62iuk72	595	7	nuclei	nucleus	NNS
cord-001859-d62iuk72	595	8	after	after	IN
cord-001859-d62iuk72	595	9	the	the	DT
cord-001859-d62iuk72	595	10	hypotonic	hypotonic	JJ
cord-001859-d62iuk72	595	11	swelling	swelling	NN
cord-001859-d62iuk72	595	12	step	step	NN
cord-001859-d62iuk72	595	13	,	,	,
cord-001859-d62iuk72	595	14	cells	cell	NNS
cord-001859-d62iuk72	595	15	were	be	VBD
cord-001859-d62iuk72	595	16	resuspended	resuspend	VBN
cord-001859-d62iuk72	595	17	in	in	IN
cord-001859-d62iuk72	595	18	2.2	2.2	CD
cord-001859-d62iuk72	595	19	M	M	NNP
cord-001859-d62iuk72	595	20	SHKM	SHKM	NNP
cord-001859-d62iuk72	595	21	(	(	-LRB-
cord-001859-d62iuk72	595	22	2.2	2.2	CD
cord-001859-d62iuk72	595	23	M	M	NNP
cord-001859-d62iuk72	595	24	sucrose	sucrose	NN
cord-001859-d62iuk72	595	25	,	,	,
cord-001859-d62iuk72	595	26	50	50	CD
cord-001859-d62iuk72	595	27	mM	mm	CD
cord-001859-d62iuk72	595	28	HEPES	hepes	NN
cord-001859-d62iuk72	595	29	pH	pH	NNP
cord-001859-d62iuk72	595	30	7.4	7.4	CD
cord-001859-d62iuk72	595	31	,	,	,
cord-001859-d62iuk72	595	32	25	25	CD
cord-001859-d62iuk72	595	33	mM	mm	CD
cord-001859-d62iuk72	595	34	KCl	KCl	NNS
cord-001859-d62iuk72	595	35	,	,	,
cord-001859-d62iuk72	595	36	and	and	CC
cord-001859-d62iuk72	595	37	5	5	CD
cord-001859-d62iuk72	595	38	mM	mm	CD
cord-001859-d62iuk72	595	39	MgCl	MgCl	NNS
cord-001859-d62iuk72	595	40	2	2	CD
cord-001859-d62iuk72	595	41	)	)	-RRB-
cord-001859-d62iuk72	595	42	and	and	CC
cord-001859-d62iuk72	595	43	1	1	CD
cord-001859-d62iuk72	595	44	M	M	NNP
cord-001859-d62iuk72	595	45	KCl	KCl	NNS
cord-001859-d62iuk72	595	46	.	.	.
cord-001859-d62iuk72	596	1	The	the	DT
cord-001859-d62iuk72	596	2	resuspended	resuspended	JJ
cord-001859-d62iuk72	596	3	cells	cell	NNS
cord-001859-d62iuk72	596	4	were	be	VBD
cord-001859-d62iuk72	596	5	then	then	RB
cord-001859-d62iuk72	596	6	underlayed	underlay	VBN
cord-001859-d62iuk72	596	7	with	with	IN
cord-001859-d62iuk72	596	8	30	30	CD
cord-001859-d62iuk72	596	9	%	%	NN
cord-001859-d62iuk72	596	10	SHKM	SHKM	NNP
cord-001859-d62iuk72	596	11	(	(	-LRB-
cord-001859-d62iuk72	596	12	0.9	0.9	CD
cord-001859-d62iuk72	596	13	M	M	NNP
cord-001859-d62iuk72	596	14	sucrose	sucrose	NN
cord-001859-d62iuk72	596	15	,	,	,
cord-001859-d62iuk72	596	16	50	50	CD
cord-001859-d62iuk72	596	17	mM	mm	CD
cord-001859-d62iuk72	596	18	HEPES	hepes	NN
cord-001859-d62iuk72	596	19	pH	pH	NNP
cord-001859-d62iuk72	596	20	7.4	7.4	CD
cord-001859-d62iuk72	596	21	,	,	,
cord-001859-d62iuk72	596	22	25	25	CD
cord-001859-d62iuk72	596	23	mM	mm	CD
cord-001859-d62iuk72	596	24	KCl	KCl	NNS
cord-001859-d62iuk72	596	25	,	,	,
cord-001859-d62iuk72	596	26	and	and	CC
cord-001859-d62iuk72	596	27	5	5	CD
cord-001859-d62iuk72	596	28	mM	mm	CD
cord-001859-d62iuk72	596	29	MgCl	MgCl	NNS
cord-001859-d62iuk72	596	30	2	2	CD
cord-001859-d62iuk72	596	31	)	)	-RRB-
cord-001859-d62iuk72	596	32	and	and	CC
cord-001859-d62iuk72	596	33	nuclei	nucleus	NNS
cord-001859-d62iuk72	596	34	were	be	VBD
cord-001859-d62iuk72	596	35	pelleted	pellete	VBN
cord-001859-d62iuk72	596	36	at	at	IN
cord-001859-d62iuk72	596	37	2,000xg	2,000xg	CD
cord-001859-d62iuk72	596	38	for	for	IN
cord-001859-d62iuk72	596	39	20	20	CD
cord-001859-d62iuk72	596	40	min	min	NN
cord-001859-d62iuk72	596	41	at	at	IN
cord-001859-d62iuk72	596	42	4	4	CD
cord-001859-d62iuk72	596	43	°	°	NN
cord-001859-d62iuk72	596	44	C	c	NN
cord-001859-d62iuk72	596	45	in	in	IN
cord-001859-d62iuk72	596	46	a	a	DT
cord-001859-d62iuk72	596	47	Eppendorf	Eppendorf	NNP
cord-001859-d62iuk72	596	48	centrifuge	centrifuge	NN
cord-001859-d62iuk72	596	49	5804	5804	CD
cord-001859-d62iuk72	597	1	R.	R.	NNP
cord-001859-d62iuk72	597	2	Nuclei	Nuclei	NNP
cord-001859-d62iuk72	597	3	were	be	VBD
cord-001859-d62iuk72	597	4	resuspended	resuspend	VBN
cord-001859-d62iuk72	597	5	in	in	IN
cord-001859-d62iuk72	597	6	1.9	1.9	CD
cord-001859-d62iuk72	597	7	M	M	NNP
cord-001859-d62iuk72	597	8	SHKM	SHKM	NNP
cord-001859-d62iuk72	597	9	,	,	,
cord-001859-d62iuk72	597	10	underlayed	underlayed	NNP
cord-001859-d62iuk72	597	11	with	with	IN
cord-001859-d62iuk72	597	12	2.2	2.2	CD
cord-001859-d62iuk72	597	13	M	M	NNP
cord-001859-d62iuk72	597	14	SHKM	SHKM	NNP
cord-001859-d62iuk72	597	15	and	and	CC
cord-001859-d62iuk72	597	16	transferred	transfer	VBD
cord-001859-d62iuk72	597	17	to	to	IN
cord-001859-d62iuk72	597	18	38.5-ml	38.5-ml	CD
cord-001859-d62iuk72	597	19	ultracentrifuge	ultracentrifuge	JJ
cord-001859-d62iuk72	597	20	tubes	tube	NNS
cord-001859-d62iuk72	597	21	(	(	-LRB-
cord-001859-d62iuk72	597	22	Beckman	Beckman	NNP
cord-001859-d62iuk72	597	23	Coulter	Coulter	NNP
cord-001859-d62iuk72	597	24	)	)	-RRB-
cord-001859-d62iuk72	597	25	.	.	.
cord-001859-d62iuk72	598	1	Nuclei	nucleus	NNS
cord-001859-d62iuk72	598	2	were	be	VBD
cord-001859-d62iuk72	598	3	then	then	RB
cord-001859-d62iuk72	598	4	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	598	5	at	at	IN
cord-001859-d62iuk72	598	6	82,000xg	82,000xg	CD
cord-001859-d62iuk72	598	7	for	for	IN
cord-001859-d62iuk72	598	8	2h	2h	CD
cord-001859-d62iuk72	598	9	at	at	IN
cord-001859-d62iuk72	598	10	4	4	CD
cord-001859-d62iuk72	598	11	°	°	NN
cord-001859-d62iuk72	598	12	C	c	NN
cord-001859-d62iuk72	598	13	in	in	IN
cord-001859-d62iuk72	598	14	a	a	DT
cord-001859-d62iuk72	598	15	Sorvall	Sorvall	NNP
cord-001859-d62iuk72	598	16	Discovery	Discovery	NNP
cord-001859-d62iuk72	598	17	90SE	90se	CD
cord-001859-d62iuk72	598	18	ultracentrifuge	ultracentrifuge	NN
cord-001859-d62iuk72	598	19	.	.	.
cord-001859-d62iuk72	599	1	Pellets	pellet	NNS
cord-001859-d62iuk72	599	2	were	be	VBD
cord-001859-d62iuk72	599	3	resuspended	resuspend	VBN
cord-001859-d62iuk72	599	4	in	in	IN
cord-001859-d62iuk72	599	5	0.25	0.25	CD
cord-001859-d62iuk72	599	6	M	M	NNP
cord-001859-d62iuk72	599	7	SHKM	SHKM	NNP
cord-001859-d62iuk72	599	8	(	(	-LRB-
cord-001859-d62iuk72	599	9	50	50	CD
cord-001859-d62iuk72	599	10	mM	mm	CD
cord-001859-d62iuk72	599	11	HEPES	hepes	NN
cord-001859-d62iuk72	599	12	pH	pH	NNP
cord-001859-d62iuk72	599	13	7.4	7.4	CD
cord-001859-d62iuk72	599	14	,	,	,
cord-001859-d62iuk72	599	15	25	25	CD
cord-001859-d62iuk72	599	16	mM	mm	CD
cord-001859-d62iuk72	599	17	KCl	KCl	NNS
cord-001859-d62iuk72	599	18	,	,	,
cord-001859-d62iuk72	599	19	and	and	CC
cord-001859-d62iuk72	599	20	5	5	CD
cord-001859-d62iuk72	599	21	mM	mm	CD
cord-001859-d62iuk72	599	22	MgCl	MgCl	NNS
cord-001859-d62iuk72	599	23	2	2	CD
cord-001859-d62iuk72	599	24	)	)	-RRB-
cord-001859-d62iuk72	599	25	,	,	,
cord-001859-d62iuk72	599	26	treated	treat	VBN
cord-001859-d62iuk72	599	27	with	with	IN
cord-001859-d62iuk72	599	28	1	1	CD
cord-001859-d62iuk72	599	29	%	%	NN
cord-001859-d62iuk72	599	30	Triton	Triton	NNP
cord-001859-d62iuk72	599	31	-	-	HYPH
cord-001859-d62iuk72	599	32	X	X	NNP
cord-001859-d62iuk72	599	33	in	in	IN
cord-001859-d62iuk72	599	34	10	10	CD
cord-001859-d62iuk72	599	35	%	%	NN
cord-001859-d62iuk72	599	36	SHM	shm	NN
cord-001859-d62iuk72	599	37	(	(	-LRB-
cord-001859-d62iuk72	599	38	0.3	0.3	CD
cord-001859-d62iuk72	599	39	M	M	NNP
cord-001859-d62iuk72	599	40	sucrose	sucrose	NN
cord-001859-d62iuk72	599	41	,	,	,
cord-001859-d62iuk72	599	42	10	10	CD
cord-001859-d62iuk72	599	43	mM	mm	CD
cord-001859-d62iuk72	599	44	HEPES	HEPES	NNP
cord-001859-d62iuk72	599	45	,	,	,
cord-001859-d62iuk72	599	46	pH	pH	NNP
cord-001859-d62iuk72	599	47	7.4	7.4	CD
cord-001859-d62iuk72	599	48	,	,	,
cord-001859-d62iuk72	599	49	2	2	CD
cord-001859-d62iuk72	599	50	mM	mm	CD
cord-001859-d62iuk72	599	51	MgCl	MgCl	NNP
cord-001859-d62iuk72	599	52	2	2	CD
cord-001859-d62iuk72	599	53	and	and	CC
cord-001859-d62iuk72	599	54	0.5	0.5	CD
cord-001859-d62iuk72	599	55	mM	mm	CD
cord-001859-d62iuk72	600	1	Ca	Ca	NNP
cord-001859-d62iuk72	600	2	Cl	Cl	NNP
cord-001859-d62iuk72	600	3	2	2	CD
cord-001859-d62iuk72	600	4	)	)	-RRB-
cord-001859-d62iuk72	600	5	for	for	IN
cord-001859-d62iuk72	600	6	10	10	CD
cord-001859-d62iuk72	600	7	min	min	NN
cord-001859-d62iuk72	600	8	and	and	CC
cord-001859-d62iuk72	600	9	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	600	10	at	at	IN
cord-001859-d62iuk72	600	11	2,000xg	2,000xg	CD
cord-001859-d62iuk72	600	12	for	for	IN
cord-001859-d62iuk72	600	13	10	10	CD
cord-001859-d62iuk72	600	14	min	min	NN
cord-001859-d62iuk72	600	15	.	.	.
cord-001859-d62iuk72	601	1	Nuclei	nucleus	NNS
cord-001859-d62iuk72	601	2	were	be	VBD
cord-001859-d62iuk72	601	3	then	then	RB
cord-001859-d62iuk72	601	4	treated	treat	VBN
cord-001859-d62iuk72	601	5	with	with	IN
cord-001859-d62iuk72	601	6	RNase	RNase	NNP
cord-001859-d62iuk72	601	7	A	A	NNP
cord-001859-d62iuk72	601	8	(	(	-LRB-
cord-001859-d62iuk72	601	9	Thermo	Thermo	NNP
cord-001859-d62iuk72	601	10	Scientific	Scientific	NNP
cord-001859-d62iuk72	601	11	)	)	-RRB-
cord-001859-d62iuk72	602	1	and	and	CC
cord-001859-d62iuk72	602	2	DNase	DNase	NNP
cord-001859-d62iuk72	602	3	I	-PRON-	PRP
cord-001859-d62iuk72	602	4	(	(	-LRB-
cord-001859-d62iuk72	602	5	Life	Life	NNP
cord-001859-d62iuk72	602	6	Technologies	Technologies	NNPS
cord-001859-d62iuk72	602	7	)	)	-RRB-
cord-001859-d62iuk72	602	8	for	for	IN
cord-001859-d62iuk72	602	9	15	15	CD
cord-001859-d62iuk72	602	10	min	min	NN
cord-001859-d62iuk72	602	11	,	,	,
cord-001859-d62iuk72	602	12	pelleted	pellete	VBN
cord-001859-d62iuk72	602	13	at	at	IN
cord-001859-d62iuk72	602	14	6,000xg	6,000xg	CD
cord-001859-d62iuk72	602	15	for	for	IN
cord-001859-d62iuk72	602	16	10	10	CD
cord-001859-d62iuk72	602	17	min	min	NN
cord-001859-d62iuk72	602	18	,	,	,
cord-001859-d62iuk72	602	19	resuspended	resuspend	VBD
cord-001859-d62iuk72	602	20	in	in	IN
cord-001859-d62iuk72	602	21	10	10	CD
cord-001859-d62iuk72	602	22	%	%	NN
cord-001859-d62iuk72	602	23	SHM	SHM	NNP
cord-001859-d62iuk72	602	24	and	and	CC
cord-001859-d62iuk72	602	25	treated	treat	VBN
cord-001859-d62iuk72	602	26	again	again	RB
cord-001859-d62iuk72	602	27	with	with	IN
cord-001859-d62iuk72	602	28	RNase	RNase	NNP
cord-001859-d62iuk72	602	29	A	A	NNP
cord-001859-d62iuk72	602	30	and	and	CC
cord-001859-d62iuk72	602	31	DNase	DNase	NNP
cord-001859-d62iuk72	602	32	I	i	NN
cord-001859-d62iuk72	602	33	for	for	IN
cord-001859-d62iuk72	602	34	15	15	CD
cord-001859-d62iuk72	602	35	min	min	NN
cord-001859-d62iuk72	602	36	.	.	.
cord-001859-d62iuk72	603	1	Nuclei	nucleus	NNS
cord-001859-d62iuk72	603	2	were	be	VBD
cord-001859-d62iuk72	603	3	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	603	4	at	at	IN
cord-001859-d62iuk72	603	5	2,000xg	2,000xg	CD
cord-001859-d62iuk72	603	6	for	for	IN
cord-001859-d62iuk72	603	7	10	10	CD
cord-001859-d62iuk72	603	8	min	min	NN
cord-001859-d62iuk72	603	9	,	,	,
cord-001859-d62iuk72	603	10	resuspended	resuspended	JJ
cord-001859-d62iuk72	603	11	and	and	CC
cord-001859-d62iuk72	603	12	incubated	incubate	VBN
cord-001859-d62iuk72	603	13	for	for	IN
cord-001859-d62iuk72	603	14	15	15	CD
cord-001859-d62iuk72	603	15	min	min	NN
cord-001859-d62iuk72	603	16	in	in	IN
cord-001859-d62iuk72	603	17	10	10	CD
cord-001859-d62iuk72	603	18	%	%	NN
cord-001859-d62iuk72	603	19	SHM	SHM	NNP
cord-001859-d62iuk72	603	20	containing	contain	VBG
cord-001859-d62iuk72	603	21	0.3	0.3	CD
cord-001859-d62iuk72	603	22	M	m	NN
cord-001859-d62iuk72	603	23	NaCl	nacl	NN
cord-001859-d62iuk72	603	24	to	to	TO
cord-001859-d62iuk72	603	25	remove	remove	VB
cord-001859-d62iuk72	603	26	nucleoplasmic	nucleoplasmic	JJ
cord-001859-d62iuk72	603	27	contents	content	NNS
cord-001859-d62iuk72	603	28	.	.	.
cord-001859-d62iuk72	604	1	Nuclear	nuclear	JJ
cord-001859-d62iuk72	604	2	envelopes	envelope	NNS
cord-001859-d62iuk72	604	3	were	be	VBD
cord-001859-d62iuk72	604	4	then	then	RB
cord-001859-d62iuk72	604	5	pelleted	pellete	VBN
cord-001859-d62iuk72	604	6	at	at	IN
cord-001859-d62iuk72	604	7	1,500xg	1,500xg	CD
cord-001859-d62iuk72	604	8	for	for	IN
cord-001859-d62iuk72	604	9	15	15	CD
cord-001859-d62iuk72	604	10	min	min	NN
cord-001859-d62iuk72	604	11	.	.	.
cord-001859-d62iuk72	605	1	Insoluble	insoluble	JJ
cord-001859-d62iuk72	605	2	nuclear	nuclear	JJ
cord-001859-d62iuk72	605	3	envelope	envelope	NN
cord-001859-d62iuk72	605	4	proteins	protein	NNS
cord-001859-d62iuk72	605	5	were	be	VBD
cord-001859-d62iuk72	605	6	solubilised	solubilise	VBN
cord-001859-d62iuk72	605	7	for	for	IN
cord-001859-d62iuk72	605	8	10	10	CD
cord-001859-d62iuk72	605	9	min	min	NN
cord-001859-d62iuk72	605	10	in	in	IN
cord-001859-d62iuk72	605	11	PBS	PBS	NNP
cord-001859-d62iuk72	605	12	supplemented	supplement	VBN
cord-001859-d62iuk72	605	13	with	with	IN
cord-001859-d62iuk72	605	14	0.1	0.1	CD
cord-001859-d62iuk72	605	15	%	%	NN
cord-001859-d62iuk72	605	16	Triton	Triton	NNP
cord-001859-d62iuk72	605	17	-	-	HYPH
cord-001859-d62iuk72	605	18	X100	X100	NNP
cord-001859-d62iuk72	605	19	and	and	CC
cord-001859-d62iuk72	605	20	6	6	CD
cord-001859-d62iuk72	605	21	M	m	NN
cord-001859-d62iuk72	605	22	urea	urea	NN
cord-001859-d62iuk72	605	23	.	.	.
cord-001859-d62iuk72	606	1	Samples	sample	NNS
cord-001859-d62iuk72	606	2	were	be	VBD
cord-001859-d62iuk72	606	3	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	606	4	at	at	IN
cord-001859-d62iuk72	606	5	6,000	6,000	CD
cord-001859-d62iuk72	606	6	g	g	NN
cord-001859-d62iuk72	606	7	for	for	IN
cord-001859-d62iuk72	606	8	2	2	CD
cord-001859-d62iuk72	606	9	min	min	NN
cord-001859-d62iuk72	606	10	to	to	TO
cord-001859-d62iuk72	606	11	remove	remove	VB
cord-001859-d62iuk72	606	12	insoluble	insoluble	JJ
cord-001859-d62iuk72	606	13	material	material	NN
cord-001859-d62iuk72	606	14	and	and	CC
cord-001859-d62iuk72	606	15	the	the	DT
cord-001859-d62iuk72	606	16	supernatant	supernatant	JJ
cord-001859-d62iuk72	606	17	containing	contain	VBG
cord-001859-d62iuk72	606	18	nuclear	nuclear	JJ
cord-001859-d62iuk72	606	19	envelope	envelope	NN
cord-001859-d62iuk72	606	20	proteins	protein	NNS
cord-001859-d62iuk72	606	21	was	be	VBD
cord-001859-d62iuk72	606	22	stored	store	VBN
cord-001859-d62iuk72	606	23	at	at	IN
cord-001859-d62iuk72	606	24	-80	-80	NNP
cord-001859-d62iuk72	606	25	°	°	NN
cord-001859-d62iuk72	606	26	C	c	NN
cord-001859-d62iuk72	606	27	for	for	IN
cord-001859-d62iuk72	606	28	further	further	JJ
cord-001859-d62iuk72	606	29	Western	western	JJ
cord-001859-d62iuk72	606	30	blotting	blotting	NN
cord-001859-d62iuk72	606	31	and	and	CC
cord-001859-d62iuk72	606	32	mass	mass	NN
cord-001859-d62iuk72	606	33	spectrometry	spectrometry	NN
cord-001859-d62iuk72	606	34	analysis	analysis	NN
cord-001859-d62iuk72	606	35	.	.	.
cord-001859-d62iuk72	607	1	All	all	DT
cord-001859-d62iuk72	607	2	solutions	solution	NNS
cord-001859-d62iuk72	607	3	had	have	VBD
cord-001859-d62iuk72	607	4	freshly	freshly	RB
cord-001859-d62iuk72	607	5	added	add	VBN
cord-001859-d62iuk72	607	6	1x	1x	CD
cord-001859-d62iuk72	607	7	Complete	Complete	NNP
cord-001859-d62iuk72	607	8	,	,	,
cord-001859-d62iuk72	607	9	EDTA	edta	NN
cord-001859-d62iuk72	607	10	-	-	HYPH
cord-001859-d62iuk72	607	11	free	free	JJ
cord-001859-d62iuk72	607	12	protease	protease	NN
cord-001859-d62iuk72	607	13	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	607	14	(	(	-LRB-
cord-001859-d62iuk72	607	15	Roche	Roche	NNP
cord-001859-d62iuk72	607	16	)	)	-RRB-
cord-001859-d62iuk72	607	17	.	.	.
cord-001859-d62iuk72	608	1	DTT	DTT	NNP
cord-001859-d62iuk72	608	2	(	(	-LRB-
cord-001859-d62iuk72	608	3	2	2	CD
cord-001859-d62iuk72	608	4	mM	mm	CD
cord-001859-d62iuk72	608	5	)	)	-RRB-
cord-001859-d62iuk72	608	6	was	be	VBD
cord-001859-d62iuk72	608	7	also	also	RB
cord-001859-d62iuk72	608	8	freshly	freshly	RB
cord-001859-d62iuk72	608	9	added	add	VBN
cord-001859-d62iuk72	608	10	to	to	IN
cord-001859-d62iuk72	608	11	the	the	DT
cord-001859-d62iuk72	608	12	solutions	solution	NNS
cord-001859-d62iuk72	608	13	specified	specify	VBN
cord-001859-d62iuk72	608	14	on	on	IN
cord-001859-d62iuk72	608	15	Korfali	Korfali	NNP
cord-001859-d62iuk72	608	16	's	's	POS
cord-001859-d62iuk72	608	17	protocol	protocol	NN
cord-001859-d62iuk72	608	18	.	.	.
cord-001859-d62iuk72	609	1	LC	LC	NNP
cord-001859-d62iuk72	609	2	-	-	HYPH
cord-001859-d62iuk72	609	3	MS	MS	NNP
cord-001859-d62iuk72	609	4	/	/	SYM
cord-001859-d62iuk72	609	5	MS	MS	NNP
cord-001859-d62iuk72	609	6	was	be	VBD
cord-001859-d62iuk72	609	7	performed	perform	VBN
cord-001859-d62iuk72	609	8	as	as	IN
cord-001859-d62iuk72	609	9	previously	previously	RB
cord-001859-d62iuk72	609	10	described	describe	VBN
cord-001859-d62iuk72	609	11	[	[	-LRB-
cord-001859-d62iuk72	609	12	22	22	CD
cord-001859-d62iuk72	609	13	]	]	-RRB-
cord-001859-d62iuk72	609	14	.	.	.
cord-001859-d62iuk72	610	1	Bioinformatical	Bioinformatical	NNP
cord-001859-d62iuk72	610	2	analysis	analysis	NN
cord-001859-d62iuk72	610	3	was	be	VBD
cord-001859-d62iuk72	610	4	performed	perform	VBN
cord-001859-d62iuk72	610	5	with	with	IN
cord-001859-d62iuk72	610	6	the	the	DT
cord-001859-d62iuk72	610	7	Ingenuity	Ingenuity	NNP
cord-001859-d62iuk72	610	8	Systems	Systems	NNP
cord-001859-d62iuk72	610	9	software	software	NN
cord-001859-d62iuk72	610	10	packet	packet	NN
cord-001859-d62iuk72	610	11	,	,	,
cord-001859-d62iuk72	610	12	IPA	IPA	NNP
cord-001859-d62iuk72	610	13	9.0	9.0	CD
cord-001859-d62iuk72	610	14	(	(	-LRB-
cord-001859-d62iuk72	610	15	Ingenuity	Ingenuity	NNP
cord-001859-d62iuk72	610	16	Systems	Systems	NNPS
cord-001859-d62iuk72	610	17	,	,	,
cord-001859-d62iuk72	610	18	Inc	Inc	NNP
cord-001859-d62iuk72	610	19	)	)	-RRB-
cord-001859-d62iuk72	610	20	.	.	.
cord-001859-d62iuk72	611	1	Protein	protein	NN
cord-001859-d62iuk72	611	2	samples	sample	NNS
cord-001859-d62iuk72	611	3	were	be	VBD
cord-001859-d62iuk72	611	4	extracted	extract	VBN
cord-001859-d62iuk72	611	5	using	use	VBG
cord-001859-d62iuk72	611	6	lysis	lysis	NN
cord-001859-d62iuk72	611	7	buffer	buffer	NN
cord-001859-d62iuk72	611	8	containing	contain	VBG
cord-001859-d62iuk72	611	9	50	50	CD
cord-001859-d62iuk72	611	10	mM	mm	CD
cord-001859-d62iuk72	611	11	Tris	Tris	NNP
cord-001859-d62iuk72	611	12	(	(	-LRB-
cord-001859-d62iuk72	611	13	pH	pH	NNP
cord-001859-d62iuk72	611	14	7.4	7.4	CD
cord-001859-d62iuk72	611	15	)	)	-RRB-
cord-001859-d62iuk72	611	16	,	,	,
cord-001859-d62iuk72	611	17	150	150	CD
cord-001859-d62iuk72	611	18	mM	mm	CD
cord-001859-d62iuk72	611	19	NaCl	nacl	NN
cord-001859-d62iuk72	611	20	,	,	,
cord-001859-d62iuk72	611	21	1	1	CD
cord-001859-d62iuk72	611	22	%	%	NN
cord-001859-d62iuk72	611	23	NP-40	NP-40	NNP
cord-001859-d62iuk72	611	24	and	and	CC
cord-001859-d62iuk72	611	25	1x	1x	JJ
cord-001859-d62iuk72	611	26	Complete	Complete	NNP
cord-001859-d62iuk72	611	27	,	,	,
cord-001859-d62iuk72	611	28	EDTA	edta	NN
cord-001859-d62iuk72	611	29	-	-	HYPH
cord-001859-d62iuk72	611	30	free	free	JJ
cord-001859-d62iuk72	611	31	protease	protease	NN
cord-001859-d62iuk72	611	32	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	611	33	(	(	-LRB-
cord-001859-d62iuk72	611	34	Roche	Roche	NNP
cord-001859-d62iuk72	611	35	)	)	-RRB-
cord-001859-d62iuk72	611	36	for	for	IN
cord-001859-d62iuk72	611	37	30	30	CD
cord-001859-d62iuk72	611	38	min	min	NN
cord-001859-d62iuk72	611	39	on	on	IN
cord-001859-d62iuk72	611	40	ice	ice	NN
cord-001859-d62iuk72	611	41	,	,	,
cord-001859-d62iuk72	611	42	as	as	IN
cord-001859-d62iuk72	611	43	previously	previously	RB
cord-001859-d62iuk72	611	44	described	describe	VBN
cord-001859-d62iuk72	611	45	[	[	-LRB-
cord-001859-d62iuk72	611	46	102	102	CD
cord-001859-d62iuk72	611	47	]	]	-RRB-
cord-001859-d62iuk72	611	48	.	.	.
cord-001859-d62iuk72	612	1	Protein	protein	NN
cord-001859-d62iuk72	612	2	samples	sample	NNS
cord-001859-d62iuk72	612	3	were	be	VBD
cord-001859-d62iuk72	612	4	run	run	VBN
cord-001859-d62iuk72	612	5	on	on	IN
cord-001859-d62iuk72	612	6	SDS	SDS	NNP
cord-001859-d62iuk72	612	7	-	-	HYPH
cord-001859-d62iuk72	612	8	PAGE	page	NN
cord-001859-d62iuk72	612	9	gels	gel	NNS
cord-001859-d62iuk72	612	10	and	and	CC
cord-001859-d62iuk72	612	11	transferred	transfer	VBN
cord-001859-d62iuk72	612	12	to	to	IN
cord-001859-d62iuk72	612	13	nitrocellulose	nitrocellulose	NN
cord-001859-d62iuk72	612	14	membranes	membrane	NNS
cord-001859-d62iuk72	612	15	(	(	-LRB-
cord-001859-d62iuk72	612	16	Amersham	Amersham	NNP
cord-001859-d62iuk72	612	17	)	)	-RRB-
cord-001859-d62iuk72	612	18	via	via	IN
cord-001859-d62iuk72	612	19	wet	wet	JJ
cord-001859-d62iuk72	612	20	transfer	transfer	NN
cord-001859-d62iuk72	612	21	.	.	.
cord-001859-d62iuk72	613	1	Membranes	membrane	NNS
cord-001859-d62iuk72	613	2	were	be	VBD
cord-001859-d62iuk72	613	3	blocked	block	VBN
cord-001859-d62iuk72	613	4	with	with	IN
cord-001859-d62iuk72	613	5	TBS	tbs	NN
cord-001859-d62iuk72	613	6	+	+	CC
cord-001859-d62iuk72	614	1	0.1	0.1	CD
cord-001859-d62iuk72	614	2	%	%	NN
cord-001859-d62iuk72	614	3	Tween	Tween	NNP
cord-001859-d62iuk72	614	4	20	20	CD
cord-001859-d62iuk72	614	5	and	and	CC
cord-001859-d62iuk72	614	6	5	5	CD
cord-001859-d62iuk72	614	7	%	%	NN
cord-001859-d62iuk72	614	8	dried	dry	VBN
cord-001859-d62iuk72	614	9	skimmed	skim	VBN
cord-001859-d62iuk72	614	10	milk	milk	NN
cord-001859-d62iuk72	614	11	powder	powder	NN
cord-001859-d62iuk72	614	12	.	.	.
cord-001859-d62iuk72	615	1	Membranes	membrane	NNS
cord-001859-d62iuk72	615	2	were	be	VBD
cord-001859-d62iuk72	615	3	probed	probe	VBN
cord-001859-d62iuk72	615	4	with	with	IN
cord-001859-d62iuk72	615	5	relevant	relevant	JJ
cord-001859-d62iuk72	615	6	primary	primary	JJ
cord-001859-d62iuk72	615	7	and	and	CC
cord-001859-d62iuk72	615	8	secondary	secondary	JJ
cord-001859-d62iuk72	615	9	antibodies	antibody	NNS
cord-001859-d62iuk72	615	10	,	,	,
cord-001859-d62iuk72	615	11	treated	treat	VBN
cord-001859-d62iuk72	615	12	with	with	IN
cord-001859-d62iuk72	615	13	EZ	EZ	NNP
cord-001859-d62iuk72	615	14	-	-	HYPH
cord-001859-d62iuk72	615	15	ECL	ECL	NNP
cord-001859-d62iuk72	615	16	(	(	-LRB-
cord-001859-d62iuk72	615	17	Geneflow	Geneflow	NNP
cord-001859-d62iuk72	615	18	)	)	-RRB-
cord-001859-d62iuk72	615	19	and	and	CC
cord-001859-d62iuk72	615	20	exposed	expose	VBN
cord-001859-d62iuk72	615	21	to	to	IN
cord-001859-d62iuk72	615	22	Amersham	Amersham	NNP
cord-001859-d62iuk72	615	23	hyperfilm	hyperfilm	NN
cord-001859-d62iuk72	615	24	ECL	ECL	NNP
cord-001859-d62iuk72	615	25	(	(	-LRB-
cord-001859-d62iuk72	615	26	GE	GE	NNP
cord-001859-d62iuk72	615	27	Healthcare	Healthcare	NNP
cord-001859-d62iuk72	615	28	)	)	-RRB-
cord-001859-d62iuk72	615	29	.	.	.
cord-001859-d62iuk72	616	1	Secondary	secondary	JJ
cord-001859-d62iuk72	616	2	antibodies	antibody	NNS
cord-001859-d62iuk72	616	3	were	be	VBD
cord-001859-d62iuk72	616	4	horseradish	horseradish	NN
cord-001859-d62iuk72	616	5	peroxidase	peroxidase	NN
cord-001859-d62iuk72	616	6	(	(	-LRB-
cord-001859-d62iuk72	616	7	HRP)-conjugated	HRP)-conjugated	NNP
cord-001859-d62iuk72	616	8	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	616	9	goat	goat	NN
cord-001859-d62iuk72	616	10	anti	anti	NN
cord-001859-d62iuk72	616	11	-	-	JJ
cord-001859-d62iuk72	616	12	mouse	mouse	JJ
cord-001859-d62iuk72	616	13	and	and	CC
cord-001859-d62iuk72	616	14	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	616	15	goat	goat	NN
cord-001859-d62iuk72	616	16	anti	anti	JJ
cord-001859-d62iuk72	616	17	-	-	JJ
cord-001859-d62iuk72	616	18	rabbit	rabbit	JJ
cord-001859-d62iuk72	616	19	(	(	-LRB-
cord-001859-d62iuk72	616	20	Dako	Dako	NNP
cord-001859-d62iuk72	616	21	)	)	-RRB-
cord-001859-d62iuk72	616	22	.	.	.
cord-001859-d62iuk72	617	1	HRPconjugated	hrpconjugated	JJ
cord-001859-d62iuk72	617	2	polyclonal	polyclonal	JJ
cord-001859-d62iuk72	617	3	rabbit	rabbit	NN
cord-001859-d62iuk72	617	4	anti	anti	JJ
cord-001859-d62iuk72	617	5	-	-	NNP
cord-001859-d62iuk72	617	6	sheep	sheep	NNP
cord-001859-d62iuk72	617	7	was	be	VBD
cord-001859-d62iuk72	617	8	from	from	IN
cord-001859-d62iuk72	617	9	Santa	Santa	NNP
cord-001859-d62iuk72	617	10	Cruz	Cruz	NNP
cord-001859-d62iuk72	617	11	.	.	.
cord-001859-d62iuk72	618	1	GFP	GFP	NNP
cord-001859-d62iuk72	618	2	-	-	HYPH
cord-001859-d62iuk72	618	3	Trap	Trap	NNP
cord-001859-d62iuk72	618	4	(	(	-LRB-
cord-001859-d62iuk72	618	5	Chromotek	Chromotek	NNP
cord-001859-d62iuk72	618	6	)	)	-RRB-
cord-001859-d62iuk72	618	7	experiments	experiment	NNS
cord-001859-d62iuk72	618	8	were	be	VBD
cord-001859-d62iuk72	618	9	performed	perform	VBN
cord-001859-d62iuk72	618	10	as	as	IN
cord-001859-d62iuk72	618	11	previously	previously	RB
cord-001859-d62iuk72	618	12	described	describe	VBN
cord-001859-d62iuk72	618	13	[	[	-LRB-
cord-001859-d62iuk72	618	14	103	103	CD
cord-001859-d62iuk72	618	15	]	]	-RRB-
cord-001859-d62iuk72	618	16	.	.	.
cord-001859-d62iuk72	619	1	Nuclear	nuclear	JJ
cord-001859-d62iuk72	619	2	/	/	SYM
cord-001859-d62iuk72	619	3	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	619	4	fractionations	fractionation	NNS
cord-001859-d62iuk72	619	5	were	be	VBD
cord-001859-d62iuk72	619	6	performed	perform	VBN
cord-001859-d62iuk72	619	7	as	as	IN
cord-001859-d62iuk72	619	8	previously	previously	RB
cord-001859-d62iuk72	619	9	described	describe	VBN
cord-001859-d62iuk72	619	10	[	[	-LRB-
cord-001859-d62iuk72	619	11	44	44	CD
cord-001859-d62iuk72	619	12	]	]	-RRB-
cord-001859-d62iuk72	619	13	,	,	,
cord-001859-d62iuk72	619	14	with	with	IN
cord-001859-d62iuk72	619	15	the	the	DT
cord-001859-d62iuk72	619	16	exception	exception	NN
cord-001859-d62iuk72	619	17	that	that	IN
cord-001859-d62iuk72	619	18	nuclear	nuclear	JJ
cord-001859-d62iuk72	619	19	pellets	pellet	NNS
cord-001859-d62iuk72	619	20	were	be	VBD
cord-001859-d62iuk72	619	21	solubilised	solubilise	VBN
cord-001859-d62iuk72	619	22	for	for	IN
cord-001859-d62iuk72	619	23	20	20	CD
cord-001859-d62iuk72	619	24	min	min	NN
cord-001859-d62iuk72	619	25	in	in	IN
cord-001859-d62iuk72	619	26	PBS	PBS	NNP
cord-001859-d62iuk72	619	27	supplemented	supplement	VBN
cord-001859-d62iuk72	619	28	with	with	IN
cord-001859-d62iuk72	619	29	0.1	0.1	CD
cord-001859-d62iuk72	619	30	%	%	NN
cord-001859-d62iuk72	619	31	Triton	Triton	NNP
cord-001859-d62iuk72	619	32	-	-	HYPH
cord-001859-d62iuk72	619	33	X100	X100	NNP
cord-001859-d62iuk72	619	34	and	and	CC
cord-001859-d62iuk72	619	35	6	6	CD
cord-001859-d62iuk72	619	36	M	m	NN
cord-001859-d62iuk72	619	37	urea	urea	NN
cord-001859-d62iuk72	619	38	.	.	.
cord-001859-d62iuk72	620	1	Vigorous	vigorous	JJ
cord-001859-d62iuk72	620	2	pipetting	pipetting	NN
cord-001859-d62iuk72	620	3	and	and	CC
cord-001859-d62iuk72	620	4	vortexing	vortexing	NN
cord-001859-d62iuk72	620	5	was	be	VBD
cord-001859-d62iuk72	620	6	applied	apply	VBN
cord-001859-d62iuk72	620	7	to	to	IN
cord-001859-d62iuk72	620	8	the	the	DT
cord-001859-d62iuk72	620	9	nuclear	nuclear	JJ
cord-001859-d62iuk72	620	10	pellet	pellet	NN
cord-001859-d62iuk72	620	11	.	.	.
cord-001859-d62iuk72	621	1	After	after	IN
cord-001859-d62iuk72	621	2	urea	urea	NN
cord-001859-d62iuk72	621	3	treatment	treatment	NN
cord-001859-d62iuk72	621	4	,	,	,
cord-001859-d62iuk72	621	5	insoluble	insoluble	JJ
cord-001859-d62iuk72	621	6	material	material	NN
cord-001859-d62iuk72	621	7	was	be	VBD
cord-001859-d62iuk72	621	8	removed	remove	VBN
cord-001859-d62iuk72	621	9	by	by	IN
cord-001859-d62iuk72	621	10	centrifugation	centrifugation	NN
cord-001859-d62iuk72	621	11	at	at	IN
cord-001859-d62iuk72	621	12	6,000	6,000	CD
cord-001859-d62iuk72	621	13	g	g	NN
cord-001859-d62iuk72	621	14	for	for	IN
cord-001859-d62iuk72	621	15	2	2	CD
cord-001859-d62iuk72	621	16	min	min	NN
cord-001859-d62iuk72	621	17	and	and	CC
cord-001859-d62iuk72	621	18	the	the	DT
cord-001859-d62iuk72	621	19	supernatant	supernatant	NN
cord-001859-d62iuk72	621	20	kept	keep	VBN
cord-001859-d62iuk72	621	21	for	for	IN
cord-001859-d62iuk72	621	22	further	further	JJ
cord-001859-d62iuk72	621	23	analysis	analysis	NN
cord-001859-d62iuk72	621	24	.	.	.
cord-001859-d62iuk72	622	1	Cells	cell	NNS
cord-001859-d62iuk72	622	2	were	be	VBD
cord-001859-d62iuk72	622	3	cultured	culture	VBN
cord-001859-d62iuk72	622	4	overnight	overnight	RB
cord-001859-d62iuk72	622	5	on	on	IN
cord-001859-d62iuk72	622	6	poly	poly	NNP
cord-001859-d62iuk72	622	7	-	-	HYPH
cord-001859-d62iuk72	622	8	L	l	NN
cord-001859-d62iuk72	622	9	-	-	HYPH
cord-001859-d62iuk72	622	10	lysine	lysine	NN
cord-001859-d62iuk72	622	11	(	(	-LRB-
cord-001859-d62iuk72	622	12	Life	Life	NNP
cord-001859-d62iuk72	622	13	Technologies	Technologies	NNPS
cord-001859-d62iuk72	622	14	)	)	-RRB-
cord-001859-d62iuk72	622	15	coated	coat	VBD
cord-001859-d62iuk72	622	16	glass	glass	NN
cord-001859-d62iuk72	622	17	coverslips	coverslip	NNS
cord-001859-d62iuk72	622	18	in	in	IN
cord-001859-d62iuk72	622	19	24-well	24-well	CD
cord-001859-d62iuk72	622	20	plates	plate	NNS
cord-001859-d62iuk72	622	21	.	.	.
cord-001859-d62iuk72	623	1	Cells	cell	NNS
cord-001859-d62iuk72	623	2	were	be	VBD
cord-001859-d62iuk72	623	3	fixed	fix	VBN
cord-001859-d62iuk72	623	4	with	with	IN
cord-001859-d62iuk72	623	5	4	4	CD
cord-001859-d62iuk72	623	6	%	%	NN
cord-001859-d62iuk72	623	7	formaldehyde	formaldehyde	NN
cord-001859-d62iuk72	623	8	(	(	-LRB-
cord-001859-d62iuk72	623	9	Calbiochem	Calbiochem	NNP
cord-001859-d62iuk72	623	10	)	)	-RRB-
cord-001859-d62iuk72	623	11	for	for	IN
cord-001859-d62iuk72	623	12	10	10	CD
cord-001859-d62iuk72	623	13	min	min	NN
cord-001859-d62iuk72	623	14	and	and	CC
cord-001859-d62iuk72	623	15	permeabilised	permeabilise	VBD
cord-001859-d62iuk72	623	16	with	with	IN
cord-001859-d62iuk72	623	17	0.1	0.1	CD
cord-001859-d62iuk72	623	18	%	%	NN
cord-001859-d62iuk72	623	19	Triton	Triton	NNP
cord-001859-d62iuk72	623	20	X-100	x-100	RB
cord-001859-d62iuk72	623	21	for	for	IN
cord-001859-d62iuk72	623	22	20	20	CD
cord-001859-d62iuk72	623	23	min	min	NNS
cord-001859-d62iuk72	623	24	as	as	IN
cord-001859-d62iuk72	623	25	previously	previously	RB
cord-001859-d62iuk72	623	26	described	describe	VBN
cord-001859-d62iuk72	623	27	[	[	-LRB-
cord-001859-d62iuk72	623	28	104	104	CD
cord-001859-d62iuk72	623	29	]	]	-RRB-
cord-001859-d62iuk72	623	30	.	.	.
cord-001859-d62iuk72	624	1	For	for	IN
cord-001859-d62iuk72	624	2	labelling	label	VBG
cord-001859-d62iuk72	624	3	with	with	IN
cord-001859-d62iuk72	624	4	Grp78	Grp78	NNP
cord-001859-d62iuk72	624	5	antibody	antibody	NN
cord-001859-d62iuk72	624	6	cells	cell	NNS
cord-001859-d62iuk72	624	7	were	be	VBD
cord-001859-d62iuk72	624	8	fixed	fix	VBN
cord-001859-d62iuk72	624	9	with	with	IN
cord-001859-d62iuk72	624	10	ice	ice	NN
cord-001859-d62iuk72	624	11	-	-	HYPH
cord-001859-d62iuk72	624	12	cold	cold	JJ
cord-001859-d62iuk72	624	13	100	100	CD
cord-001859-d62iuk72	624	14	%	%	NN
cord-001859-d62iuk72	624	15	methanol	methanol	NN
cord-001859-d62iuk72	624	16	for	for	IN
cord-001859-d62iuk72	624	17	five	five	CD
cord-001859-d62iuk72	624	18	min	min	NN
cord-001859-d62iuk72	624	19	.	.	.
cord-001859-d62iuk72	625	1	After	after	IN
cord-001859-d62iuk72	625	2	permeabilization	permeabilization	NN
cord-001859-d62iuk72	625	3	,	,	,
cord-001859-d62iuk72	625	4	cells	cell	NNS
cord-001859-d62iuk72	625	5	were	be	VBD
cord-001859-d62iuk72	625	6	then	then	RB
cord-001859-d62iuk72	625	7	incubated	incubate	VBN
cord-001859-d62iuk72	625	8	in	in	IN
cord-001859-d62iuk72	625	9	blocking	block	VBG
cord-001859-d62iuk72	625	10	solution	solution	NN
cord-001859-d62iuk72	625	11	(	(	-LRB-
cord-001859-d62iuk72	625	12	PBS	PBS	NNP
cord-001859-d62iuk72	625	13	with	with	IN
cord-001859-d62iuk72	625	14	1	1	CD
cord-001859-d62iuk72	625	15	%	%	NN
cord-001859-d62iuk72	625	16	BSA	BSA	NNP
cord-001859-d62iuk72	625	17	)	)	-RRB-
cord-001859-d62iuk72	625	18	for	for	IN
cord-001859-d62iuk72	625	19	1	1	CD
cord-001859-d62iuk72	625	20	h	h	NN
cord-001859-d62iuk72	625	21	at	at	IN
cord-001859-d62iuk72	625	22	37	37	CD
cord-001859-d62iuk72	625	23	°	°	NN
cord-001859-d62iuk72	625	24	C	c	NN
cord-001859-d62iuk72	625	25	.	.	.
cord-001859-d62iuk72	626	1	Primary	primary	JJ
cord-001859-d62iuk72	626	2	antibodies	antibody	NNS
cord-001859-d62iuk72	627	1	anti	anti	JJ
cord-001859-d62iuk72	627	2	-	-	JJ
cord-001859-d62iuk72	627	3	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	627	4	(	(	-LRB-
cord-001859-d62iuk72	627	5	diluted	dilute	VBN
cord-001859-d62iuk72	627	6	1:200	1:200	CD
cord-001859-d62iuk72	627	7	)	)	-RRB-
cord-001859-d62iuk72	627	8	,	,	,
cord-001859-d62iuk72	627	9	anti	anti	JJ
cord-001859-d62iuk72	627	10	-	-	JJ
cord-001859-d62iuk72	627	11	iHsp70	ihsp70	JJ
cord-001859-d62iuk72	627	12	(	(	-LRB-
cord-001859-d62iuk72	627	13	1:50	1:50	CD
cord-001859-d62iuk72	627	14	)	)	-RRB-
cord-001859-d62iuk72	627	15	,	,	,
cord-001859-d62iuk72	627	16	anti	anti	NNP
cord-001859-d62iuk72	627	17	-	-	NNP
cord-001859-d62iuk72	627	18	Grp78	Grp78	NNP
cord-001859-d62iuk72	627	19	(	(	-LRB-
cord-001859-d62iuk72	627	20	1:50	1:50	CD
cord-001859-d62iuk72	627	21	)	)	-RRB-
cord-001859-d62iuk72	627	22	,	,	,
cord-001859-d62iuk72	627	23	anti	anti	JJ
cord-001859-d62iuk72	627	24	-	-	JJ
cord-001859-d62iuk72	627	25	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	627	26	(	(	-LRB-
cord-001859-d62iuk72	627	27	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	627	28	)	)	-RRB-
cord-001859-d62iuk72	628	1	(	(	-LRB-
cord-001859-d62iuk72	628	2	1:500	1:500	CD
cord-001859-d62iuk72	628	3	)	)	-RRB-
cord-001859-d62iuk72	628	4	or	or	CC
cord-001859-d62iuk72	628	5	rabbit	rabbit	NN
cord-001859-d62iuk72	628	6	RTA	RTA	NNP
cord-001859-d62iuk72	628	7	(	(	-LRB-
cord-001859-d62iuk72	628	8	1:1,000	1:1,000	CD
cord-001859-d62iuk72	628	9	)	)	-RRB-
cord-001859-d62iuk72	628	10	were	be	VBD
cord-001859-d62iuk72	628	11	incubated	incubate	VBN
cord-001859-d62iuk72	628	12	for	for	IN
cord-001859-d62iuk72	628	13	1	1	CD
cord-001859-d62iuk72	628	14	h	h	NN
cord-001859-d62iuk72	628	15	at	at	IN
cord-001859-d62iuk72	628	16	37	37	CD
cord-001859-d62iuk72	628	17	°	°	NN
cord-001859-d62iuk72	628	18	C	c	NN
cord-001859-d62iuk72	628	19	.	.	.
cord-001859-d62iuk72	629	1	Coverslips	coverslip	NNS
cord-001859-d62iuk72	629	2	were	be	VBD
cord-001859-d62iuk72	629	3	washed	wash	VBN
cord-001859-d62iuk72	629	4	five	five	CD
cord-001859-d62iuk72	629	5	times	time	NNS
cord-001859-d62iuk72	629	6	with	with	IN
cord-001859-d62iuk72	629	7	PBS	PBS	NNP
cord-001859-d62iuk72	629	8	,	,	,
cord-001859-d62iuk72	629	9	incubated	incubate	VBN
cord-001859-d62iuk72	629	10	with	with	IN
cord-001859-d62iuk72	629	11	appropriate	appropriate	JJ
cord-001859-d62iuk72	629	12	secondary	secondary	JJ
cord-001859-d62iuk72	629	13	antibody	antibody	NN
cord-001859-d62iuk72	629	14	for	for	IN
cord-001859-d62iuk72	629	15	1	1	CD
cord-001859-d62iuk72	629	16	h	h	NN
cord-001859-d62iuk72	629	17	at	at	IN
cord-001859-d62iuk72	629	18	37	37	CD
cord-001859-d62iuk72	629	19	°	°	NN
cord-001859-d62iuk72	629	20	C	c	NN
cord-001859-d62iuk72	629	21	,	,	,
cord-001859-d62iuk72	629	22	washed	wash	VBD
cord-001859-d62iuk72	629	23	five	five	CD
cord-001859-d62iuk72	629	24	times	time	NNS
cord-001859-d62iuk72	629	25	with	with	IN
cord-001859-d62iuk72	629	26	PBS	PBS	NNP
cord-001859-d62iuk72	629	27	again	again	RB
cord-001859-d62iuk72	629	28	and	and	CC
cord-001859-d62iuk72	629	29	mounted	mount	VBD
cord-001859-d62iuk72	629	30	in	in	IN
cord-001859-d62iuk72	629	31	VECTASHIELD	VECTASHIELD	NNP
cord-001859-d62iuk72	629	32	with	with	IN
cord-001859-d62iuk72	629	33	DAPI	DAPI	NNP
cord-001859-d62iuk72	629	34	(	(	-LRB-
cord-001859-d62iuk72	629	35	Vector	Vector	NNP
cord-001859-d62iuk72	629	36	Labs	Labs	NNP
cord-001859-d62iuk72	629	37	)	)	-RRB-
cord-001859-d62iuk72	629	38	.	.	.
cord-001859-d62iuk72	630	1	Images	image	NNS
cord-001859-d62iuk72	630	2	were	be	VBD
cord-001859-d62iuk72	630	3	obtained	obtain	VBN
cord-001859-d62iuk72	630	4	using	use	VBG
cord-001859-d62iuk72	630	5	a	a	DT
cord-001859-d62iuk72	630	6	LSM	LSM	NNP
cord-001859-d62iuk72	630	7	510	510	CD
cord-001859-d62iuk72	630	8	META	META	NNP
cord-001859-d62iuk72	630	9	confocal	confocal	JJ
cord-001859-d62iuk72	630	10	microscope	microscope	NN
cord-001859-d62iuk72	630	11	(	(	-LRB-
cord-001859-d62iuk72	630	12	Carl	Carl	NNP
cord-001859-d62iuk72	630	13	Zeiss	Zeiss	NNP
cord-001859-d62iuk72	630	14	)	)	-RRB-
cord-001859-d62iuk72	630	15	and	and	CC
cord-001859-d62iuk72	630	16	processed	process	VBN
cord-001859-d62iuk72	630	17	using	use	VBG
cord-001859-d62iuk72	630	18	ZEN	ZEN	NNP
cord-001859-d62iuk72	630	19	2009	2009	CD
cord-001859-d62iuk72	630	20	imaging	imaging	NN
cord-001859-d62iuk72	630	21	software	software	NN
cord-001859-d62iuk72	630	22	(	(	-LRB-
cord-001859-d62iuk72	630	23	Carl	Carl	NNP
cord-001859-d62iuk72	630	24	Zeiss	Zeiss	NNP
cord-001859-d62iuk72	630	25	)	)	-RRB-
cord-001859-d62iuk72	631	1	as	as	IN
cord-001859-d62iuk72	631	2	previously	previously	RB
cord-001859-d62iuk72	631	3	described	describe	VBN
cord-001859-d62iuk72	631	4	[	[	-LRB-
cord-001859-d62iuk72	631	5	105	105	CD
cord-001859-d62iuk72	631	6	]	]	-RRB-
cord-001859-d62iuk72	631	7	.	.	.
cord-001859-d62iuk72	632	1	Fluorescentlyconjugated	fluorescentlyconjugated	JJ
cord-001859-d62iuk72	632	2	secondary	secondary	JJ
cord-001859-d62iuk72	632	3	antibodies	antibody	NNS
cord-001859-d62iuk72	632	4	were	be	VBD
cord-001859-d62iuk72	632	5	all	all	DT
cord-001859-d62iuk72	632	6	obtained	obtain	VBN
cord-001859-d62iuk72	632	7	from	from	IN
cord-001859-d62iuk72	632	8	Life	Life	NNP
cord-001859-d62iuk72	632	9	Technologies	Technologies	NNPS
cord-001859-d62iuk72	632	10	:	:	:
cord-001859-d62iuk72	633	1	Alexa	Alexa	NNP
cord-001859-d62iuk72	633	2	Flour	Flour	NNP
cord-001859-d62iuk72	633	3	633	633	CD
cord-001859-d62iuk72	633	4	goat	goat	NN
cord-001859-d62iuk72	633	5	anti	anti	JJ
cord-001859-d62iuk72	633	6	-	-	JJ
cord-001859-d62iuk72	633	7	mouse	mouse	JJ
cord-001859-d62iuk72	633	8	IgG	igg	NN
cord-001859-d62iuk72	633	9	,	,	,
cord-001859-d62iuk72	633	10	Alexa	Alexa	NNP
cord-001859-d62iuk72	633	11	Flour	Flour	NNP
cord-001859-d62iuk72	634	1	488	488	CD
cord-001859-d62iuk72	634	2	goat	goat	NN
cord-001859-d62iuk72	634	3	anti	anti	JJ
cord-001859-d62iuk72	634	4	-	-	JJ
cord-001859-d62iuk72	634	5	mouse	mouse	JJ
cord-001859-d62iuk72	634	6	IgG	igg	NN
cord-001859-d62iuk72	634	7	,	,	,
cord-001859-d62iuk72	634	8	Alexa	Alexa	NNP
cord-001859-d62iuk72	634	9	Flour	Flour	NNP
cord-001859-d62iuk72	635	1	488	488	CD
cord-001859-d62iuk72	635	2	goat	goat	NN
cord-001859-d62iuk72	635	3	anti	anti	JJ
cord-001859-d62iuk72	635	4	-	-	JJ
cord-001859-d62iuk72	635	5	rabbit	rabbit	JJ
cord-001859-d62iuk72	635	6	IgG	igg	NN
cord-001859-d62iuk72	635	7	,	,	.
cord-001859-d62iuk72	636	1	Alexa	Alexa	NNP
cord-001859-d62iuk72	636	2	Flour	Flour	NNP
cord-001859-d62iuk72	636	3	546	546	CD
cord-001859-d62iuk72	636	4	donkey	donkey	NN
cord-001859-d62iuk72	636	5	anti	anti	JJ
cord-001859-d62iuk72	636	6	-	-	JJ
cord-001859-d62iuk72	636	7	mouse	mouse	JJ
cord-001859-d62iuk72	636	8	IgG	igg	NN
cord-001859-d62iuk72	636	9	and	and	CC
cord-001859-d62iuk72	636	10	Alexa	Alexa	NNP
cord-001859-d62iuk72	636	11	Flour	Flour	NNP
cord-001859-d62iuk72	636	12	546	546	CD
cord-001859-d62iuk72	636	13	goat	goat	NN
cord-001859-d62iuk72	636	14	anti	anti	JJ
cord-001859-d62iuk72	636	15	-	-	JJ
cord-001859-d62iuk72	636	16	rabbit	rabbit	JJ
cord-001859-d62iuk72	636	17	IgG.	IgG.	NNP
cord-001859-d62iuk72	636	18	TREx	TREx	NNS
cord-001859-d62iuk72	636	19	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	636	20	cells	cell	NNS
cord-001859-d62iuk72	636	21	were	be	VBD
cord-001859-d62iuk72	636	22	labelled	label	VBN
cord-001859-d62iuk72	636	23	using	use	VBG
cord-001859-d62iuk72	636	24	the	the	DT
cord-001859-d62iuk72	636	25	Click	Click	NNP
cord-001859-d62iuk72	636	26	-	-	HYPH
cord-001859-d62iuk72	636	27	iT	it	PRP
cord-001859-d62iuk72	636	28	EdU	edu	NN
cord-001859-d62iuk72	636	29	Alexa	Alexa	NNP
cord-001859-d62iuk72	636	30	Fluor	Fluor	NNP
cord-001859-d62iuk72	636	31	647	647	NNP
cord-001859-d62iuk72	636	32	Imaging	Imaging	NNP
cord-001859-d62iuk72	636	33	Kit	Kit	NNP
cord-001859-d62iuk72	636	34	(	(	-LRB-
cord-001859-d62iuk72	636	35	Life	Life	NNP
cord-001859-d62iuk72	636	36	Technologies	Technologies	NNPS
cord-001859-d62iuk72	636	37	)	)	-RRB-
cord-001859-d62iuk72	636	38	according	accord	VBG
cord-001859-d62iuk72	636	39	to	to	IN
cord-001859-d62iuk72	636	40	the	the	DT
cord-001859-d62iuk72	636	41	manufacturer	manufacturer	NN
cord-001859-d62iuk72	636	42	's	's	POS
cord-001859-d62iuk72	636	43	instructions	instruction	NNS
cord-001859-d62iuk72	636	44	with	with	IN
cord-001859-d62iuk72	636	45	minor	minor	JJ
cord-001859-d62iuk72	636	46	modifications	modification	NNS
cord-001859-d62iuk72	636	47	as	as	IN
cord-001859-d62iuk72	636	48	follows	follow	VBZ
cord-001859-d62iuk72	636	49	.	.	.
cord-001859-d62iuk72	637	1	Cells	cell	NNS
cord-001859-d62iuk72	637	2	were	be	VBD
cord-001859-d62iuk72	637	3	seeded	seed	VBN
cord-001859-d62iuk72	637	4	onto	onto	IN
cord-001859-d62iuk72	637	5	poly	poly	NNP
cord-001859-d62iuk72	637	6	-	-	HYPH
cord-001859-d62iuk72	637	7	L	l	NN
cord-001859-d62iuk72	637	8	-	-	HYPH
cord-001859-d62iuk72	637	9	lysine	lysine	NN
cord-001859-d62iuk72	637	10	treated	treat	VBN
cord-001859-d62iuk72	637	11	coverslips	coverslip	NNS
cord-001859-d62iuk72	637	12	in	in	IN
cord-001859-d62iuk72	637	13	24-well	24-well	CD
cord-001859-d62iuk72	637	14	plates	plate	NNS
cord-001859-d62iuk72	637	15	followed	follow	VBN
cord-001859-d62iuk72	637	16	by	by	IN
cord-001859-d62iuk72	637	17	induction	induction	NN
cord-001859-d62iuk72	637	18	and	and	CC
cord-001859-d62iuk72	637	19	incubation	incubation	NN
cord-001859-d62iuk72	637	20	at	at	IN
cord-001859-d62iuk72	637	21	37	37	CD
cord-001859-d62iuk72	637	22	°	°	NN
cord-001859-d62iuk72	637	23	C	c	NN
cord-001859-d62iuk72	637	24	for	for	IN
cord-001859-d62iuk72	637	25	24	24	CD
cord-001859-d62iuk72	637	26	hours	hour	NNS
cord-001859-d62iuk72	637	27	.	.	.
cord-001859-d62iuk72	638	1	Prior	prior	RB
cord-001859-d62iuk72	638	2	to	to	IN
cord-001859-d62iuk72	638	3	cell	cell	NN
cord-001859-d62iuk72	638	4	fixation	fixation	NN
cord-001859-d62iuk72	638	5	,	,	,
cord-001859-d62iuk72	638	6	10	10	CD
cord-001859-d62iuk72	638	7	μM	μM	NNP
cord-001859-d62iuk72	638	8	EdU	edu	NN
cord-001859-d62iuk72	638	9	(	(	-LRB-
cord-001859-d62iuk72	638	10	5-ethynyl-2'deoxyuridine	5-ethynyl-2'deoxyuridine	CD
cord-001859-d62iuk72	638	11	)	)	-RRB-
cord-001859-d62iuk72	638	12	was	be	VBD
cord-001859-d62iuk72	638	13	added	add	VBN
cord-001859-d62iuk72	638	14	to	to	IN
cord-001859-d62iuk72	638	15	each	each	DT
cord-001859-d62iuk72	638	16	well	well	NN
cord-001859-d62iuk72	638	17	for	for	IN
cord-001859-d62iuk72	638	18	45	45	CD
cord-001859-d62iuk72	638	19	min	min	NN
cord-001859-d62iuk72	638	20	.	.	.
cord-001859-d62iuk72	639	1	Cells	cell	NNS
cord-001859-d62iuk72	639	2	were	be	VBD
cord-001859-d62iuk72	639	3	then	then	RB
cord-001859-d62iuk72	639	4	fixed	fix	VBN
cord-001859-d62iuk72	639	5	for	for	IN
cord-001859-d62iuk72	639	6	10	10	CD
cord-001859-d62iuk72	639	7	min	min	NN
cord-001859-d62iuk72	639	8	in	in	IN
cord-001859-d62iuk72	639	9	4	4	CD
cord-001859-d62iuk72	639	10	%	%	NN
cord-001859-d62iuk72	639	11	formaldehyde	formaldehyde	NN
cord-001859-d62iuk72	639	12	and	and	CC
cord-001859-d62iuk72	639	13	permeabilised	permeabilise	VBN
cord-001859-d62iuk72	639	14	in	in	IN
cord-001859-d62iuk72	639	15	1	1	CD
cord-001859-d62iuk72	639	16	%	%	NN
cord-001859-d62iuk72	639	17	Triton	Triton	NNP
cord-001859-d62iuk72	639	18	X-100	x-100	RB
cord-001859-d62iuk72	639	19	for	for	IN
cord-001859-d62iuk72	639	20	20	20	CD
cord-001859-d62iuk72	639	21	min	min	NN
cord-001859-d62iuk72	639	22	.	.	.
cord-001859-d62iuk72	640	1	Edu	Edu	NNP
cord-001859-d62iuk72	640	2	detection	detection	NN
cord-001859-d62iuk72	640	3	was	be	VBD
cord-001859-d62iuk72	640	4	carried	carry	VBN
cord-001859-d62iuk72	640	5	out	out	RP
cord-001859-d62iuk72	640	6	adding	add	VBG
cord-001859-d62iuk72	640	7	the	the	DT
cord-001859-d62iuk72	640	8	Click	Click	NNP
cord-001859-d62iuk72	640	9	-	-	HYPH
cord-001859-d62iuk72	640	10	iT	it	PRP
cord-001859-d62iuk72	640	11	reaction	reaction	NN
cord-001859-d62iuk72	640	12	cocktail	cocktail	NN
cord-001859-d62iuk72	640	13	for	for	IN
cord-001859-d62iuk72	640	14	30	30	CD
cord-001859-d62iuk72	640	15	min	min	NN
cord-001859-d62iuk72	640	16	and	and	CC
cord-001859-d62iuk72	640	17	immunofluorescent	immunofluorescent	NN
cord-001859-d62iuk72	640	18	labelling	labelling	NN
cord-001859-d62iuk72	640	19	for	for	IN
cord-001859-d62iuk72	640	20	RTA	RTA	NNP
cord-001859-d62iuk72	640	21	and	and	CC
cord-001859-d62iuk72	640	22	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	640	23	was	be	VBD
cord-001859-d62iuk72	640	24	performed	perform	VBN
cord-001859-d62iuk72	640	25	as	as	IN
cord-001859-d62iuk72	640	26	above	above	RB
cord-001859-d62iuk72	640	27	.	.	.
cord-001859-d62iuk72	641	1	Cells	cell	NNS
cord-001859-d62iuk72	641	2	were	be	VBD
cord-001859-d62iuk72	641	3	mounted	mount	VBN
cord-001859-d62iuk72	641	4	in	in	IN
cord-001859-d62iuk72	641	5	VECTASHIELD	VECTASHIELD	NNP
cord-001859-d62iuk72	641	6	with	with	IN
cord-001859-d62iuk72	641	7	DAPI	DAPI	NNP
cord-001859-d62iuk72	641	8	(	(	-LRB-
cord-001859-d62iuk72	641	9	Vector	Vector	NNP
cord-001859-d62iuk72	641	10	Labs	Labs	NNP
cord-001859-d62iuk72	641	11	)	)	-RRB-
cord-001859-d62iuk72	641	12	.	.	.
cord-001859-d62iuk72	642	1	Total	Total	NNP
cord-001859-d62iuk72	642	2	RNA	RNA	NNP
cord-001859-d62iuk72	642	3	from	from	IN
cord-001859-d62iuk72	642	4	cells	cell	NNS
cord-001859-d62iuk72	642	5	was	be	VBD
cord-001859-d62iuk72	642	6	extracted	extract	VBN
cord-001859-d62iuk72	642	7	using	use	VBG
cord-001859-d62iuk72	642	8	TRIzol	TRIzol	NNP
cord-001859-d62iuk72	642	9	(	(	-LRB-
cord-001859-d62iuk72	642	10	Life	Life	NNP
cord-001859-d62iuk72	642	11	Technologies	Technologies	NNPS
cord-001859-d62iuk72	642	12	)	)	-RRB-
cord-001859-d62iuk72	642	13	according	accord	VBG
cord-001859-d62iuk72	642	14	to	to	IN
cord-001859-d62iuk72	642	15	the	the	DT
cord-001859-d62iuk72	642	16	supplier	supplier	NN
cord-001859-d62iuk72	642	17	's	's	POS
cord-001859-d62iuk72	642	18	protocol	protocol	NN
cord-001859-d62iuk72	642	19	.	.	.
cord-001859-d62iuk72	643	1	DNA	dna	NN
cord-001859-d62iuk72	643	2	-	-	HYPH
cord-001859-d62iuk72	643	3	free	free	JJ
cord-001859-d62iuk72	643	4	DNA	DNA	NNP
cord-001859-d62iuk72	643	5	Removal	Removal	NNP
cord-001859-d62iuk72	643	6	Kit	kit	NN
cord-001859-d62iuk72	643	7	(	(	-LRB-
cord-001859-d62iuk72	643	8	Ambion	Ambion	NNP
cord-001859-d62iuk72	643	9	)	)	-RRB-
cord-001859-d62iuk72	643	10	was	be	VBD
cord-001859-d62iuk72	643	11	used	use	VBN
cord-001859-d62iuk72	643	12	to	to	TO
cord-001859-d62iuk72	643	13	remove	remove	VB
cord-001859-d62iuk72	643	14	any	any	DT
cord-001859-d62iuk72	643	15	contaminating	contaminate	VBG
cord-001859-d62iuk72	643	16	DNA	dna	NN
cord-001859-d62iuk72	643	17	from	from	IN
cord-001859-d62iuk72	643	18	RNA	RNA	NNP
cord-001859-d62iuk72	643	19	samples	sample	NNS
cord-001859-d62iuk72	643	20	.	.	.
cord-001859-d62iuk72	644	1	Reverse	reverse	JJ
cord-001859-d62iuk72	644	2	transcription	transcription	NN
cord-001859-d62iuk72	644	3	was	be	VBD
cord-001859-d62iuk72	644	4	performed	perform	VBN
cord-001859-d62iuk72	644	5	with	with	IN
cord-001859-d62iuk72	644	6	ProtoScript	ProtoScript	NNP
cord-001859-d62iuk72	644	7	II	II	NNP
cord-001859-d62iuk72	644	8	(	(	-LRB-
cord-001859-d62iuk72	644	9	NEB	NEB	NNP
cord-001859-d62iuk72	644	10	)	)	-RRB-
cord-001859-d62iuk72	644	11	and	and	CC
cord-001859-d62iuk72	644	12	oligo(dT	oligo(dt	CD
cord-001859-d62iuk72	644	13	)	)	-RRB-
cord-001859-d62iuk72	644	14	primers	primer	NNS
cord-001859-d62iuk72	644	15	and	and	CC
cord-001859-d62iuk72	644	16	1.5	1.5	CD
cord-001859-d62iuk72	644	17	μg	μg	NNS
cord-001859-d62iuk72	644	18	of	of	IN
cord-001859-d62iuk72	644	19	total	total	JJ
cord-001859-d62iuk72	644	20	RNA	RNA	NNP
cord-001859-d62iuk72	644	21	.	.	.
cord-001859-d62iuk72	645	1	Negative	negative	JJ
cord-001859-d62iuk72	645	2	control	control	NN
cord-001859-d62iuk72	645	3	reactions	reaction	NNS
cord-001859-d62iuk72	645	4	were	be	VBD
cord-001859-d62iuk72	645	5	performed	perform	VBN
cord-001859-d62iuk72	645	6	in	in	IN
cord-001859-d62iuk72	645	7	the	the	DT
cord-001859-d62iuk72	645	8	same	same	JJ
cord-001859-d62iuk72	645	9	manner	manner	NN
cord-001859-d62iuk72	645	10	but	but	CC
cord-001859-d62iuk72	645	11	without	without	IN
cord-001859-d62iuk72	645	12	reverse	reverse	JJ
cord-001859-d62iuk72	645	13	transcriptase	transcriptase	NN
cord-001859-d62iuk72	645	14	.	.	.
cord-001859-d62iuk72	646	1	Quantitative	quantitative	JJ
cord-001859-d62iuk72	646	2	PCR	PCR	NNP
cord-001859-d62iuk72	646	3	(	(	-LRB-
cord-001859-d62iuk72	646	4	qPCR	qPCR	NNP
cord-001859-d62iuk72	646	5	)	)	-RRB-
cord-001859-d62iuk72	646	6	reactions	reaction	NNS
cord-001859-d62iuk72	646	7	(	(	-LRB-
cord-001859-d62iuk72	646	8	20	20	CD
cord-001859-d62iuk72	646	9	μl	μl	NN
cord-001859-d62iuk72	646	10	)	)	-RRB-
cord-001859-d62iuk72	646	11	included	include	VBN
cord-001859-d62iuk72	646	12	1X	1x	CD
cord-001859-d62iuk72	646	13	SensiMix	SensiMix	NNP
cord-001859-d62iuk72	646	14	SYBR	SYBR	NNP
cord-001859-d62iuk72	646	15	green	green	JJ
cord-001859-d62iuk72	646	16	master	master	NN
cord-001859-d62iuk72	646	17	mix	mix	NN
cord-001859-d62iuk72	646	18	(	(	-LRB-
cord-001859-d62iuk72	646	19	Bioline	Bioline	NNP
cord-001859-d62iuk72	646	20	)	)	-RRB-
cord-001859-d62iuk72	646	21	,	,	.
cord-001859-d62iuk72	647	1	0.5	0.5	CD
cord-001859-d62iuk72	647	2	μM	μm	CD
cord-001859-d62iuk72	647	3	of	of	IN
cord-001859-d62iuk72	647	4	each	each	DT
cord-001859-d62iuk72	647	5	primer	primer	NN
cord-001859-d62iuk72	647	6	and	and	CC
cord-001859-d62iuk72	647	7	5	5	CD
cord-001859-d62iuk72	647	8	μl	μl	NN
cord-001859-d62iuk72	647	9	template	template	NN
cord-001859-d62iuk72	647	10	cDNA	cdna	NN
cord-001859-d62iuk72	647	11	(	(	-LRB-
cord-001859-d62iuk72	647	12	used	use	VBN
cord-001859-d62iuk72	647	13	at	at	IN
cord-001859-d62iuk72	647	14	1:200	1:200	CD
cord-001859-d62iuk72	647	15	dilution	dilution	NN
cord-001859-d62iuk72	647	16	in	in	IN
cord-001859-d62iuk72	647	17	RNase	rnase	NN
cord-001859-d62iuk72	647	18	-	-	HYPH
cord-001859-d62iuk72	647	19	free	free	JJ
cord-001859-d62iuk72	647	20	water	water	NN
cord-001859-d62iuk72	647	21	)	)	-RRB-
cord-001859-d62iuk72	647	22	.	.	.
cord-001859-d62iuk72	648	1	Cycling	cycling	NN
cord-001859-d62iuk72	648	2	was	be	VBD
cord-001859-d62iuk72	648	3	performed	perform	VBN
cord-001859-d62iuk72	648	4	in	in	IN
cord-001859-d62iuk72	648	5	a	a	DT
cord-001859-d62iuk72	648	6	Rotor	rotor	NN
cord-001859-d62iuk72	648	7	-	-	HYPH
cord-001859-d62iuk72	648	8	Gene	gene	NN
cord-001859-d62iuk72	648	9	Q	Q	NNP
cord-001859-d62iuk72	648	10	machine	machine	NN
cord-001859-d62iuk72	648	11	(	(	-LRB-
cord-001859-d62iuk72	648	12	Eppendorf	Eppendorf	NNP
cord-001859-d62iuk72	648	13	)	)	-RRB-
cord-001859-d62iuk72	648	14	.	.	.
cord-001859-d62iuk72	649	1	The	the	DT
cord-001859-d62iuk72	649	2	cycling	cycling	NN
cord-001859-d62iuk72	649	3	programme	programme	NN
cord-001859-d62iuk72	649	4	was	be	VBD
cord-001859-d62iuk72	649	5	a	a	DT
cord-001859-d62iuk72	649	6	10	10	CD
cord-001859-d62iuk72	649	7	min	min	NN
cord-001859-d62iuk72	649	8	initial	initial	JJ
cord-001859-d62iuk72	649	9	preincubation	preincubation	NN
cord-001859-d62iuk72	649	10	at	at	IN
cord-001859-d62iuk72	649	11	95	95	CD
cord-001859-d62iuk72	649	12	°	°	NN
cord-001859-d62iuk72	649	13	C	c	NN
cord-001859-d62iuk72	649	14	,	,	,
cord-001859-d62iuk72	649	15	followed	follow	VBN
cord-001859-d62iuk72	649	16	by	by	IN
cord-001859-d62iuk72	649	17	40	40	CD
cord-001859-d62iuk72	649	18	cycles	cycle	NNS
cord-001859-d62iuk72	649	19	of	of	IN
cord-001859-d62iuk72	649	20	95	95	CD
cord-001859-d62iuk72	649	21	°	°	NN
cord-001859-d62iuk72	649	22	C	c	NN
cord-001859-d62iuk72	649	23	for	for	IN
cord-001859-d62iuk72	649	24	15	15	CD
cord-001859-d62iuk72	649	25	sec	sec	NNP
cord-001859-d62iuk72	649	26	,	,	,
cord-001859-d62iuk72	649	27	60	60	CD
cord-001859-d62iuk72	649	28	°	°	NN
cord-001859-d62iuk72	649	29	C	c	NN
cord-001859-d62iuk72	649	30	for	for	IN
cord-001859-d62iuk72	649	31	30	30	CD
cord-001859-d62iuk72	649	32	sec	sec	NNP
cord-001859-d62iuk72	649	33	and	and	CC
cord-001859-d62iuk72	649	34	72	72	CD
cord-001859-d62iuk72	649	35	°	°	NN
cord-001859-d62iuk72	649	36	C	c	NN
cord-001859-d62iuk72	649	37	for	for	IN
cord-001859-d62iuk72	649	38	20	20	CD
cord-001859-d62iuk72	649	39	sec	sec	NNP
cord-001859-d62iuk72	649	40	.	.	.
cord-001859-d62iuk72	650	1	After	after	IN
cord-001859-d62iuk72	650	2	qPCR	qPCR	NNP
cord-001859-d62iuk72	650	3	,	,	,
cord-001859-d62iuk72	650	4	a	a	DT
cord-001859-d62iuk72	650	5	melting	melt	VBG
cord-001859-d62iuk72	650	6	curve	curve	NN
cord-001859-d62iuk72	650	7	analysis	analysis	NN
cord-001859-d62iuk72	650	8	was	be	VBD
cord-001859-d62iuk72	650	9	performed	perform	VBN
cord-001859-d62iuk72	650	10	between	between	IN
cord-001859-d62iuk72	650	11	65	65	CD
cord-001859-d62iuk72	650	12	and	and	CC
cord-001859-d62iuk72	650	13	95	95	CD
cord-001859-d62iuk72	650	14	°	°	NN
cord-001859-d62iuk72	650	15	C	c	NN
cord-001859-d62iuk72	650	16	(	(	-LRB-
cord-001859-d62iuk72	650	17	with	with	IN
cord-001859-d62iuk72	650	18	0.2	0.2	CD
cord-001859-d62iuk72	650	19	°	°	NN
cord-001859-d62iuk72	650	20	C	c	NN
cord-001859-d62iuk72	650	21	increments	increment	NNS
cord-001859-d62iuk72	650	22	)	)	-RRB-
cord-001859-d62iuk72	650	23	to	to	TO
cord-001859-d62iuk72	650	24	confirm	confirm	VB
cord-001859-d62iuk72	650	25	amplification	amplification	NN
cord-001859-d62iuk72	650	26	of	of	IN
cord-001859-d62iuk72	650	27	a	a	DT
cord-001859-d62iuk72	650	28	single	single	JJ
cord-001859-d62iuk72	650	29	product	product	NN
cord-001859-d62iuk72	650	30	.	.	.
cord-001859-d62iuk72	651	1	Relative	relative	JJ
cord-001859-d62iuk72	651	2	expression	expression	NN
cord-001859-d62iuk72	651	3	compared	compare	VBN
cord-001859-d62iuk72	651	4	to	to	IN
cord-001859-d62iuk72	651	5	control	control	NN
cord-001859-d62iuk72	651	6	cells	cell	NNS
cord-001859-d62iuk72	651	7	was	be	VBD
cord-001859-d62iuk72	651	8	calculated	calculate	VBN
cord-001859-d62iuk72	651	9	using	use	VBG
cord-001859-d62iuk72	651	10	the	the	DT
cord-001859-d62iuk72	651	11	ΔΔC	ΔΔC	NNP
cord-001859-d62iuk72	651	12	T	T	NNP
cord-001859-d62iuk72	651	13	method	method	NN
cord-001859-d62iuk72	651	14	as	as	IN
cord-001859-d62iuk72	651	15	previously	previously	RB
cord-001859-d62iuk72	651	16	described	describe	VBN
cord-001859-d62iuk72	651	17	[	[	-LRB-
cord-001859-d62iuk72	651	18	106	106	CD
cord-001859-d62iuk72	651	19	]	]	-RRB-
cord-001859-d62iuk72	651	20	.	.	.
cord-001859-d62iuk72	652	1	For	for	IN
cord-001859-d62iuk72	652	2	each	each	DT
cord-001859-d62iuk72	652	3	gene	gene	NN
cord-001859-d62iuk72	652	4	of	of	IN
cord-001859-d62iuk72	652	5	interest	interest	NN
cord-001859-d62iuk72	652	6	and	and	CC
cord-001859-d62iuk72	652	7	housekeeping	housekeeping	NN
cord-001859-d62iuk72	652	8	gene	gene	NN
cord-001859-d62iuk72	652	9	(	(	-LRB-
cord-001859-d62iuk72	652	10	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	652	11	)	)	-RRB-
cord-001859-d62iuk72	653	1	a	a	DT
cord-001859-d62iuk72	653	2	standard	standard	JJ
cord-001859-d62iuk72	653	3	curve	curve	NN
cord-001859-d62iuk72	653	4	was	be	VBD
cord-001859-d62iuk72	653	5	constructed	construct	VBN
cord-001859-d62iuk72	653	6	using	use	VBG
cord-001859-d62iuk72	653	7	a	a	DT
cord-001859-d62iuk72	653	8	pool	pool	NN
cord-001859-d62iuk72	653	9	of	of	IN
cord-001859-d62iuk72	653	10	cDNA	cdna	NN
cord-001859-d62iuk72	653	11	derived	derive	VBN
cord-001859-d62iuk72	653	12	from	from	IN
cord-001859-d62iuk72	653	13	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	653	14	and	and	CC
cord-001859-d62iuk72	653	15	reactivated	reactivate	VBD
cord-001859-d62iuk72	653	16	cells	cell	NNS
cord-001859-d62iuk72	653	17	.	.	.
cord-001859-d62iuk72	654	1	Six	six	CD
cord-001859-d62iuk72	654	2	different	different	JJ
cord-001859-d62iuk72	654	3	dilutions	dilution	NNS
cord-001859-d62iuk72	654	4	of	of	IN
cord-001859-d62iuk72	654	5	the	the	DT
cord-001859-d62iuk72	654	6	standards	standard	NNS
cord-001859-d62iuk72	654	7	were	be	VBD
cord-001859-d62iuk72	654	8	quantified	quantify	VBN
cord-001859-d62iuk72	654	9	,	,	,
cord-001859-d62iuk72	654	10	these	these	DT
cord-001859-d62iuk72	654	11	included	include	VBD
cord-001859-d62iuk72	654	12	1:100	1:100	CD
cord-001859-d62iuk72	654	13	,	,	,
cord-001859-d62iuk72	654	14	1:200	1:200	CD
cord-001859-d62iuk72	654	15	,	,	,
cord-001859-d62iuk72	654	16	1:400	1:400	CD
cord-001859-d62iuk72	654	17	,	,	,
cord-001859-d62iuk72	654	18	1:800	1:800	CD
cord-001859-d62iuk72	654	19	,	,	,
cord-001859-d62iuk72	654	20	1:1,600	1:1,600	CD
cord-001859-d62iuk72	654	21	and	and	CC
cord-001859-d62iuk72	654	22	1:3,200	1:3,200	CD
cord-001859-d62iuk72	654	23	dilution	dilution	NN
cord-001859-d62iuk72	654	24	.	.	.
cord-001859-d62iuk72	655	1	The	the	DT
cord-001859-d62iuk72	655	2	slope	slope	NN
cord-001859-d62iuk72	655	3	of	of	IN
cord-001859-d62iuk72	655	4	the	the	DT
cord-001859-d62iuk72	655	5	standard	standard	JJ
cord-001859-d62iuk72	655	6	curve	curve	NN
cord-001859-d62iuk72	655	7	was	be	VBD
cord-001859-d62iuk72	655	8	used	use	VBN
cord-001859-d62iuk72	655	9	to	to	TO
cord-001859-d62iuk72	655	10	calculate	calculate	VB
cord-001859-d62iuk72	655	11	the	the	DT
cord-001859-d62iuk72	655	12	amplification	amplification	NN
cord-001859-d62iuk72	655	13	efficiency	efficiency	NN
cord-001859-d62iuk72	655	14	(	(	-LRB-
cord-001859-d62iuk72	655	15	AE	AE	NNP
cord-001859-d62iuk72	655	16	)	)	-RRB-
cord-001859-d62iuk72	655	17	of	of	IN
cord-001859-d62iuk72	655	18	the	the	DT
cord-001859-d62iuk72	655	19	primers	primer	NNS
cord-001859-d62iuk72	655	20	using	use	VBG
cord-001859-d62iuk72	655	21	the	the	DT
cord-001859-d62iuk72	655	22	formula	formula	NN
cord-001859-d62iuk72	655	23	:	:	:
cord-001859-d62iuk72	655	24	AE	AE	NNP
cord-001859-d62iuk72	655	25	=	=	NFP
cord-001859-d62iuk72	655	26	(	(	-LRB-
cord-001859-d62iuk72	655	27	10	10	CD
cord-001859-d62iuk72	655	28	−1	−1	NNP
cord-001859-d62iuk72	655	29	/	/	SYM
cord-001859-d62iuk72	655	30	slope	slope	NN
cord-001859-d62iuk72	655	31	)	)	-RRB-
cord-001859-d62iuk72	655	32	.	.	.
cord-001859-d62iuk72	656	1	The	the	DT
cord-001859-d62iuk72	656	2	mean	mean	JJ
cord-001859-d62iuk72	656	3	cycle	cycle	NN
cord-001859-d62iuk72	656	4	threshold	threshold	NN
cord-001859-d62iuk72	656	5	(	(	-LRB-
cord-001859-d62iuk72	656	6	C	C	NNP
cord-001859-d62iuk72	656	7	T	T	NNP
cord-001859-d62iuk72	656	8	)	)	-RRB-
cord-001859-d62iuk72	656	9	was	be	VBD
cord-001859-d62iuk72	656	10	determined	determine	VBN
cord-001859-d62iuk72	656	11	from	from	IN
cord-001859-d62iuk72	656	12	three	three	CD
cord-001859-d62iuk72	656	13	independent	independent	JJ
cord-001859-d62iuk72	656	14	biological	biological	JJ
cord-001859-d62iuk72	656	15	replicates	replicate	NNS
cord-001859-d62iuk72	656	16	.	.	.
cord-001859-d62iuk72	657	1	All	all	DT
cord-001859-d62iuk72	657	2	genes	gene	NNS
cord-001859-d62iuk72	657	3	of	of	IN
cord-001859-d62iuk72	657	4	interest	interest	NN
cord-001859-d62iuk72	657	5	were	be	VBD
cord-001859-d62iuk72	657	6	normalised	normalise	VBN
cord-001859-d62iuk72	657	7	against	against	IN
cord-001859-d62iuk72	657	8	the	the	DT
cord-001859-d62iuk72	657	9	housekeeping	housekeeping	NN
cord-001859-d62iuk72	657	10	gene	gene	NN
cord-001859-d62iuk72	657	11	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	657	12	(	(	-LRB-
cord-001859-d62iuk72	657	13	ΔC	ΔC	NNP
cord-001859-d62iuk72	657	14	T	T	NNP
cord-001859-d62iuk72	657	15	)	)	-RRB-
cord-001859-d62iuk72	657	16	.	.	.
cord-001859-d62iuk72	658	1	ΔΔC	ΔΔC	NNP
cord-001859-d62iuk72	658	2	T	T	NNP
cord-001859-d62iuk72	658	3	was	be	VBD
cord-001859-d62iuk72	658	4	calculated	calculate	VBN
cord-001859-d62iuk72	658	5	subtracting	subtract	VBG
cord-001859-d62iuk72	658	6	ΔC	ΔC	NNP
cord-001859-d62iuk72	658	7	T	T	NNP
cord-001859-d62iuk72	658	8	of	of	IN
cord-001859-d62iuk72	658	9	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	658	10	cells	cell	NNS
cord-001859-d62iuk72	658	11	from	from	IN
cord-001859-d62iuk72	658	12	ΔC	ΔC	NNP
cord-001859-d62iuk72	658	13	T	T	NNP
cord-001859-d62iuk72	658	14	of	of	IN
cord-001859-d62iuk72	658	15	reactivated	reactivate	VBN
cord-001859-d62iuk72	658	16	cells	cell	NNS
cord-001859-d62iuk72	658	17	and	and	CC
cord-001859-d62iuk72	658	18	the	the	DT
cord-001859-d62iuk72	658	19	fold	fold	JJ
cord-001859-d62iuk72	658	20	change	change	NN
cord-001859-d62iuk72	658	21	was	be	VBD
cord-001859-d62iuk72	658	22	then	then	RB
cord-001859-d62iuk72	658	23	determined	determine	VBN
cord-001859-d62iuk72	658	24	using	use	VBG
cord-001859-d62iuk72	658	25	AE	AE	NNP
cord-001859-d62iuk72	658	26	(	(	-LRB-
cord-001859-d62iuk72	658	27	-ΔΔC	-ΔΔC	-RRB-
cord-001859-d62iuk72	658	28	T	T	NNP
cord-001859-d62iuk72	658	29	)	)	-RRB-
cord-001859-d62iuk72	658	30	.	.	.
cord-001859-d62iuk72	659	1	Statistical	statistical	JJ
cord-001859-d62iuk72	659	2	significance	significance	NN
cord-001859-d62iuk72	659	3	was	be	VBD
cord-001859-d62iuk72	659	4	validated	validate	VBN
cord-001859-d62iuk72	659	5	by	by	IN
cord-001859-d62iuk72	659	6	Student	Student	NNP
cord-001859-d62iuk72	659	7	's	's	POS
cord-001859-d62iuk72	659	8	t	t	NN
cord-001859-d62iuk72	659	9	-	-	HYPH
cord-001859-d62iuk72	659	10	test	test	NN
cord-001859-d62iuk72	659	11	.	.	.
cord-001859-d62iuk72	660	1	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	660	2	TREx	TREx	NNS
cord-001859-d62iuk72	660	3	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	660	4	cells	cell	NNS
cord-001859-d62iuk72	660	5	treated	treat	VBN
cord-001859-d62iuk72	660	6	with	with	IN
cord-001859-d62iuk72	660	7	DMSO	DMSO	NNP
cord-001859-d62iuk72	660	8	(	(	-LRB-
cord-001859-d62iuk72	660	9	0.1	0.1	CD
cord-001859-d62iuk72	660	10	%	%	NN
cord-001859-d62iuk72	660	11	)	)	-RRB-
cord-001859-d62iuk72	660	12	were	be	VBD
cord-001859-d62iuk72	660	13	used	use	VBN
cord-001859-d62iuk72	660	14	as	as	IN
cord-001859-d62iuk72	660	15	control	control	NN
cord-001859-d62iuk72	660	16	to	to	TO
cord-001859-d62iuk72	660	17	assess	assess	VB
cord-001859-d62iuk72	660	18	viral	viral	JJ
cord-001859-d62iuk72	660	19	reactivation	reactivation	NN
cord-001859-d62iuk72	660	20	.	.	.
cord-001859-d62iuk72	661	1	Reactivated	reactivate	VBN
cord-001859-d62iuk72	661	2	cells	cell	NNS
cord-001859-d62iuk72	661	3	were	be	VBD
cord-001859-d62iuk72	661	4	exposed	expose	VBN
cord-001859-d62iuk72	661	5	to	to	IN
cord-001859-d62iuk72	661	6	doxycycline	doxycycline	NN
cord-001859-d62iuk72	661	7	for	for	IN
cord-001859-d62iuk72	661	8	72	72	CD
cord-001859-d62iuk72	661	9	h.	h.	NNP
cord-001859-d62iuk72	661	10	Total	total	JJ
cord-001859-d62iuk72	661	11	DNA	DNA	NNP
cord-001859-d62iuk72	661	12	was	be	VBD
cord-001859-d62iuk72	661	13	then	then	RB
cord-001859-d62iuk72	661	14	isolated	isolate	VBN
cord-001859-d62iuk72	661	15	with	with	IN
cord-001859-d62iuk72	661	16	the	the	DT
cord-001859-d62iuk72	661	17	use	use	NN
cord-001859-d62iuk72	661	18	of	of	IN
cord-001859-d62iuk72	661	19	a	a	DT
cord-001859-d62iuk72	661	20	QIAamp	QIAamp	NNP
cord-001859-d62iuk72	661	21	DNA	dna	NN
cord-001859-d62iuk72	661	22	mini	mini	NN
cord-001859-d62iuk72	661	23	kit	kit	NN
cord-001859-d62iuk72	661	24	(	(	-LRB-
cord-001859-d62iuk72	661	25	Qiagen	Qiagen	NNP
cord-001859-d62iuk72	661	26	)	)	-RRB-
cord-001859-d62iuk72	661	27	as	as	IN
cord-001859-d62iuk72	661	28	per	per	IN
cord-001859-d62iuk72	661	29	the	the	DT
cord-001859-d62iuk72	661	30	manufacturer	manufacturer	NN
cord-001859-d62iuk72	661	31	's	's	POS
cord-001859-d62iuk72	661	32	instructions	instruction	NNS
cord-001859-d62iuk72	661	33	.	.	.
cord-001859-d62iuk72	662	1	qPCR	qPCR	NNP
cord-001859-d62iuk72	662	2	was	be	VBD
cord-001859-d62iuk72	662	3	carried	carry	VBN
cord-001859-d62iuk72	662	4	out	out	RP
cord-001859-d62iuk72	662	5	as	as	IN
cord-001859-d62iuk72	662	6	described	describe	VBN
cord-001859-d62iuk72	662	7	above	above	RB
cord-001859-d62iuk72	662	8	.	.	.
cord-001859-d62iuk72	663	1	10	10	CD
cord-001859-d62iuk72	663	2	ng	ng	NN
cord-001859-d62iuk72	663	3	of	of	IN
cord-001859-d62iuk72	663	4	template	template	NN
cord-001859-d62iuk72	663	5	DNA	dna	NN
cord-001859-d62iuk72	663	6	and	and	CC
cord-001859-d62iuk72	663	7	primers	primer	NNS
cord-001859-d62iuk72	663	8	specific	specific	JJ
cord-001859-d62iuk72	663	9	for	for	IN
cord-001859-d62iuk72	663	10	the	the	DT
cord-001859-d62iuk72	663	11	ORF57	ORF57	NNP
cord-001859-d62iuk72	663	12	gene	gene	NN
cord-001859-d62iuk72	663	13	were	be	VBD
cord-001859-d62iuk72	663	14	used	use	VBN
cord-001859-d62iuk72	663	15	.	.	.
cord-001859-d62iuk72	664	1	Quantification	quantification	NN
cord-001859-d62iuk72	664	2	of	of	IN
cord-001859-d62iuk72	664	3	GAPDH	GAPDH	NNP
cord-001859-d62iuk72	664	4	gene	gene	NN
cord-001859-d62iuk72	664	5	was	be	VBD
cord-001859-d62iuk72	664	6	used	use	VBN
cord-001859-d62iuk72	664	7	to	to	TO
cord-001859-d62iuk72	664	8	normalize	normalize	VB
cord-001859-d62iuk72	664	9	between	between	IN
cord-001859-d62iuk72	664	10	samples	sample	NNS
cord-001859-d62iuk72	664	11	and	and	CC
cord-001859-d62iuk72	664	12	the	the	DT
cord-001859-d62iuk72	664	13	mean	mean	JJ
cord-001859-d62iuk72	664	14	cycle	cycle	NN
cord-001859-d62iuk72	664	15	threshold	threshold	NN
cord-001859-d62iuk72	664	16	(	(	-LRB-
cord-001859-d62iuk72	664	17	C	C	NNP
cord-001859-d62iuk72	664	18	T	T	NNP
cord-001859-d62iuk72	664	19	)	)	-RRB-
cord-001859-d62iuk72	664	20	was	be	VBD
cord-001859-d62iuk72	664	21	determined	determine	VBN
cord-001859-d62iuk72	664	22	from	from	IN
cord-001859-d62iuk72	664	23	three	three	CD
cord-001859-d62iuk72	664	24	independent	independent	JJ
cord-001859-d62iuk72	664	25	biological	biological	JJ
cord-001859-d62iuk72	664	26	replicates	replicate	NNS
cord-001859-d62iuk72	664	27	.	.	.
cord-001859-d62iuk72	665	1	Relative	relative	JJ
cord-001859-d62iuk72	665	2	levels	level	NNS
cord-001859-d62iuk72	665	3	of	of	IN
cord-001859-d62iuk72	665	4	viral	viral	JJ
cord-001859-d62iuk72	665	5	DNA	dna	NN
cord-001859-d62iuk72	665	6	compared	compare	VBN
cord-001859-d62iuk72	665	7	with	with	IN
cord-001859-d62iuk72	665	8	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	665	9	cells	cell	NNS
cord-001859-d62iuk72	665	10	were	be	VBD
cord-001859-d62iuk72	665	11	calculated	calculate	VBN
cord-001859-d62iuk72	665	12	using	use	VBG
cord-001859-d62iuk72	665	13	the	the	DT
cord-001859-d62iuk72	665	14	ΔΔC	ΔΔC	NNP
cord-001859-d62iuk72	665	15	T	T	NNP
cord-001859-d62iuk72	665	16	method	method	NN
cord-001859-d62iuk72	665	17	as	as	IN
cord-001859-d62iuk72	665	18	previously	previously	RB
cord-001859-d62iuk72	665	19	described	describe	VBN
cord-001859-d62iuk72	665	20	[	[	-LRB-
cord-001859-d62iuk72	665	21	106	106	CD
cord-001859-d62iuk72	665	22	]	]	-RRB-
cord-001859-d62iuk72	665	23	.	.	.
cord-001859-d62iuk72	666	1	TREx	TREx	NNP
cord-001859-d62iuk72	666	2	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	666	3	cells	cell	NNS
cord-001859-d62iuk72	666	4	that	that	WDT
cord-001859-d62iuk72	666	5	had	have	VBD
cord-001859-d62iuk72	666	6	been	be	VBN
cord-001859-d62iuk72	666	7	seeded	seed	VBN
cord-001859-d62iuk72	666	8	on	on	IN
cord-001859-d62iuk72	666	9	12-well	12-well	CD
cord-001859-d62iuk72	666	10	plates	plate	NNS
cord-001859-d62iuk72	666	11	were	be	VBD
cord-001859-d62iuk72	666	12	reactivated	reactivate	VBN
cord-001859-d62iuk72	666	13	and	and	CC
cord-001859-d62iuk72	666	14	treated	treat	VBN
cord-001859-d62iuk72	666	15	with	with	IN
cord-001859-d62iuk72	666	16	control	control	NN
cord-001859-d62iuk72	666	17	DMSO	DMSO	NNP
cord-001859-d62iuk72	666	18	(	(	-LRB-
cord-001859-d62iuk72	666	19	0.1	0.1	CD
cord-001859-d62iuk72	666	20	%	%	NN
cord-001859-d62iuk72	666	21	)	)	-RRB-
cord-001859-d62iuk72	666	22	or	or	CC
cord-001859-d62iuk72	666	23	VER-155008	ver-155008	NN
cord-001859-d62iuk72	666	24	.	.	.
cord-001859-d62iuk72	667	1	Unreactivated	unreactivate	VBN
cord-001859-d62iuk72	667	2	cells	cell	NNS
cord-001859-d62iuk72	667	3	treated	treat	VBN
cord-001859-d62iuk72	667	4	with	with	IN
cord-001859-d62iuk72	667	5	DMSO	DMSO	NNP
cord-001859-d62iuk72	667	6	(	(	-LRB-
cord-001859-d62iuk72	667	7	0.1	0.1	CD
cord-001859-d62iuk72	667	8	%	%	NN
cord-001859-d62iuk72	667	9	)	)	-RRB-
cord-001859-d62iuk72	667	10	were	be	VBD
cord-001859-d62iuk72	667	11	used	use	VBN
cord-001859-d62iuk72	667	12	as	as	IN
cord-001859-d62iuk72	667	13	control	control	NN
cord-001859-d62iuk72	667	14	to	to	TO
cord-001859-d62iuk72	667	15	evaluate	evaluate	VB
cord-001859-d62iuk72	667	16	viral	viral	JJ
cord-001859-d62iuk72	667	17	reactivation	reactivation	NN
cord-001859-d62iuk72	667	18	.	.	.
cord-001859-d62iuk72	668	1	After	after	IN
cord-001859-d62iuk72	668	2	72	72	CD
cord-001859-d62iuk72	668	3	h	h	NN
cord-001859-d62iuk72	668	4	reactivation	reactivation	NN
cord-001859-d62iuk72	668	5	,	,	,
cord-001859-d62iuk72	668	6	700	700	CD
cord-001859-d62iuk72	668	7	μl	μl	NN
cord-001859-d62iuk72	668	8	of	of	IN
cord-001859-d62iuk72	668	9	the	the	DT
cord-001859-d62iuk72	668	10	RPMI	RPMI	NNP
cord-001859-d62iuk72	668	11	1640	1640	CD
cord-001859-d62iuk72	668	12	culture	culture	NN
cord-001859-d62iuk72	668	13	medium	medium	NN
cord-001859-d62iuk72	668	14	was	be	VBD
cord-001859-d62iuk72	668	15	centrifuged	centrifuge	VBN
cord-001859-d62iuk72	668	16	at	at	IN
cord-001859-d62iuk72	668	17	800	800	CD
cord-001859-d62iuk72	668	18	g	g	NN
cord-001859-d62iuk72	668	19	for	for	IN
cord-001859-d62iuk72	668	20	five	five	CD
cord-001859-d62iuk72	668	21	min	min	NN
cord-001859-d62iuk72	668	22	,	,	,
cord-001859-d62iuk72	668	23	immediately	immediately	RB
cord-001859-d62iuk72	668	24	mixed	mix	VBD
cord-001859-d62iuk72	668	25	with	with	IN
cord-001859-d62iuk72	668	26	300	300	CD
cord-001859-d62iuk72	668	27	μl	μl	NN
cord-001859-d62iuk72	668	28	of	of	IN
cord-001859-d62iuk72	668	29	DMEM	DMEM	NNP
cord-001859-d62iuk72	668	30	supplemented	supplement	VBN
cord-001859-d62iuk72	668	31	with	with	IN
cord-001859-d62iuk72	668	32	10	10	CD
cord-001859-d62iuk72	668	33	%	%	NN
cord-001859-d62iuk72	668	34	FCS	FCS	NNP
cord-001859-d62iuk72	668	35	and	and	CC
cord-001859-d62iuk72	668	36	1	1	CD
cord-001859-d62iuk72	668	37	%	%	NN
cord-001859-d62iuk72	668	38	P	p	NN
cord-001859-d62iuk72	668	39	/	/	SYM
cord-001859-d62iuk72	668	40	S	S	NNP
cord-001859-d62iuk72	668	41	and	and	CC
cord-001859-d62iuk72	668	42	incubated	incubate	VBD
cord-001859-d62iuk72	668	43	for	for	IN
cord-001859-d62iuk72	668	44	a	a	DT
cord-001859-d62iuk72	668	45	further	further	JJ
cord-001859-d62iuk72	668	46	24	24	CD
cord-001859-d62iuk72	668	47	h	h	NN
cord-001859-d62iuk72	668	48	with	with	IN
cord-001859-d62iuk72	668	49	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	668	50	T	T	NNP
cord-001859-d62iuk72	668	51	cells	cell	NNS
cord-001859-d62iuk72	668	52	that	that	WDT
cord-001859-d62iuk72	668	53	had	have	VBD
cord-001859-d62iuk72	668	54	been	be	VBN
cord-001859-d62iuk72	668	55	seeded	seed	VBN
cord-001859-d62iuk72	668	56	in	in	IN
cord-001859-d62iuk72	668	57	12-well	12-well	CD
cord-001859-d62iuk72	668	58	plates	plate	NNS
cord-001859-d62iuk72	668	59	the	the	DT
cord-001859-d62iuk72	668	60	previous	previous	JJ
cord-001859-d62iuk72	668	61	day	day	NN
cord-001859-d62iuk72	668	62	.	.	.
cord-001859-d62iuk72	669	1	Total	Total	NNP
cord-001859-d62iuk72	669	2	RNA	RNA	NNP
cord-001859-d62iuk72	669	3	was	be	VBD
cord-001859-d62iuk72	669	4	then	then	RB
cord-001859-d62iuk72	669	5	extracted	extract	VBN
cord-001859-d62iuk72	669	6	with	with	IN
cord-001859-d62iuk72	669	7	TRIzol	TRIzol	NNP
cord-001859-d62iuk72	669	8	(	(	-LRB-
cord-001859-d62iuk72	669	9	Life	Life	NNP
cord-001859-d62iuk72	669	10	Technologies	Technologies	NNPS
cord-001859-d62iuk72	669	11	)	)	-RRB-
cord-001859-d62iuk72	669	12	and	and	CC
cord-001859-d62iuk72	669	13	qRT	qRT	NNP
cord-001859-d62iuk72	669	14	-	-	HYPH
cord-001859-d62iuk72	669	15	PCR	PCR	NNP
cord-001859-d62iuk72	669	16	carried	carry	VBD
cord-001859-d62iuk72	669	17	out	out	RP
cord-001859-d62iuk72	669	18	as	as	IN
cord-001859-d62iuk72	669	19	described	describe	VBN
cord-001859-d62iuk72	669	20	above	above	RB
cord-001859-d62iuk72	669	21	.	.	.
cord-001859-d62iuk72	670	1	Relative	relative	JJ
cord-001859-d62iuk72	670	2	expression	expression	NN
cord-001859-d62iuk72	670	3	compared	compare	VBN
cord-001859-d62iuk72	670	4	to	to	IN
cord-001859-d62iuk72	670	5	control	control	NN
cord-001859-d62iuk72	670	6	cells	cell	NNS
cord-001859-d62iuk72	670	7	was	be	VBD
cord-001859-d62iuk72	670	8	calculated	calculate	VBN
cord-001859-d62iuk72	670	9	using	use	VBG
cord-001859-d62iuk72	670	10	the	the	DT
cord-001859-d62iuk72	670	11	ΔΔC	ΔΔC	NNP
cord-001859-d62iuk72	670	12	T	T	NNP
cord-001859-d62iuk72	670	13	method	method	NN
cord-001859-d62iuk72	670	14	as	as	IN
cord-001859-d62iuk72	670	15	previously	previously	RB
cord-001859-d62iuk72	670	16	described	describe	VBN
cord-001859-d62iuk72	670	17	[	[	-LRB-
cord-001859-d62iuk72	670	18	106	106	CD
cord-001859-d62iuk72	670	19	]	]	-RRB-
cord-001859-d62iuk72	670	20	.	.	.
cord-001859-d62iuk72	671	1	Determination	determination	NN
cord-001859-d62iuk72	671	2	of	of	IN
cord-001859-d62iuk72	671	3	the	the	DT
cord-001859-d62iuk72	671	4	cellular	cellular	JJ
cord-001859-d62iuk72	671	5	metabolic	metabolic	JJ
cord-001859-d62iuk72	671	6	activity	activity	NN
cord-001859-d62iuk72	671	7	was	be	VBD
cord-001859-d62iuk72	671	8	performed	perform	VBN
cord-001859-d62iuk72	671	9	using	use	VBG
cord-001859-d62iuk72	671	10	a	a	DT
cord-001859-d62iuk72	671	11	non	non	JJ
cord-001859-d62iuk72	671	12	-	-	JJ
cord-001859-d62iuk72	671	13	radioactive	radioactive	JJ
cord-001859-d62iuk72	671	14	CellTiter	CellTiter	NNP
cord-001859-d62iuk72	671	15	96	96	CD
cord-001859-d62iuk72	671	16	AQ	AQ	NNP
cord-001859-d62iuk72	671	17	ueous	ueous	JJ
cord-001859-d62iuk72	671	18	One	one	CD
cord-001859-d62iuk72	671	19	Solution	Solution	NNP
cord-001859-d62iuk72	671	20	Cell	Cell	NNP
cord-001859-d62iuk72	671	21	Proliferation	Proliferation	NNP
cord-001859-d62iuk72	671	22	Assay	Assay	NNP
cord-001859-d62iuk72	671	23	(	(	-LRB-
cord-001859-d62iuk72	671	24	MTS	MTS	NNP
cord-001859-d62iuk72	671	25	)	)	-RRB-
cord-001859-d62iuk72	671	26	(	(	-LRB-
cord-001859-d62iuk72	671	27	Promega	Promega	NNP
cord-001859-d62iuk72	671	28	)	)	-RRB-
cord-001859-d62iuk72	671	29	,	,	,
cord-001859-d62iuk72	671	30	according	accord	VBG
cord-001859-d62iuk72	671	31	to	to	IN
cord-001859-d62iuk72	671	32	the	the	DT
cord-001859-d62iuk72	671	33	manufacturer	manufacturer	NN
cord-001859-d62iuk72	671	34	's	's	POS
cord-001859-d62iuk72	671	35	manual	manual	NN
cord-001859-d62iuk72	671	36	.	.	.
cord-001859-d62iuk72	672	1	20,000	20,000	CD
cord-001859-d62iuk72	672	2	cells	cell	NNS
cord-001859-d62iuk72	672	3	TREx	TREx	NNS
cord-001859-d62iuk72	672	4	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	672	5	or	or	CC
cord-001859-d62iuk72	672	6	10,000	10,000	CD
cord-001859-d62iuk72	672	7	HEK-293	hek-293	JJ
cord-001859-d62iuk72	672	8	T	t	NN
cord-001859-d62iuk72	672	9	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	672	10	cells	cell	NNS
cord-001859-d62iuk72	672	11	were	be	VBD
cord-001859-d62iuk72	672	12	seeded	seed	VBN
cord-001859-d62iuk72	672	13	in	in	IN
cord-001859-d62iuk72	672	14	triplicate	triplicate	NN
cord-001859-d62iuk72	672	15	in	in	IN
cord-001859-d62iuk72	672	16	a	a	DT
cord-001859-d62iuk72	672	17	flat	flat	JJ
cord-001859-d62iuk72	672	18	96-well	96-well	CD
cord-001859-d62iuk72	672	19	culture	culture	NN
cord-001859-d62iuk72	672	20	plate	plate	NN
cord-001859-d62iuk72	672	21	(	(	-LRB-
cord-001859-d62iuk72	672	22	Corning	Corning	NNP
cord-001859-d62iuk72	672	23	)	)	-RRB-
cord-001859-d62iuk72	672	24	.	.	.
cord-001859-d62iuk72	673	1	After	after	IN
cord-001859-d62iuk72	673	2	24	24	CD
cord-001859-d62iuk72	673	3	h	h	NN
cord-001859-d62iuk72	673	4	inhibitor	inhibitor	NN
cord-001859-d62iuk72	673	5	exposure	exposure	NN
cord-001859-d62iuk72	673	6	,	,	,
cord-001859-d62iuk72	673	7	CellTiter	CellTiter	NNP
cord-001859-d62iuk72	673	8	96	96	CD
cord-001859-d62iuk72	673	9	AQueous	AQueous	NNP
cord-001859-d62iuk72	673	10	One	one	CD
cord-001859-d62iuk72	673	11	Solution	Solution	NNP
cord-001859-d62iuk72	673	12	Reagent	Reagent	NNP
cord-001859-d62iuk72	673	13	was	be	VBD
cord-001859-d62iuk72	673	14	added	add	VBN
cord-001859-d62iuk72	673	15	and	and	CC
cord-001859-d62iuk72	673	16	cells	cell	NNS
cord-001859-d62iuk72	673	17	were	be	VBD
cord-001859-d62iuk72	673	18	incubated	incubate	VBN
cord-001859-d62iuk72	673	19	for	for	IN
cord-001859-d62iuk72	673	20	1	1	CD
cord-001859-d62iuk72	673	21	h	h	NN
cord-001859-d62iuk72	673	22	in	in	IN
cord-001859-d62iuk72	673	23	a	a	DT
cord-001859-d62iuk72	673	24	humidified	humidify	VBN
cord-001859-d62iuk72	673	25	incubator	incubator	NN
cord-001859-d62iuk72	673	26	in	in	IN
cord-001859-d62iuk72	673	27	5	5	CD
cord-001859-d62iuk72	673	28	%	%	NN
cord-001859-d62iuk72	673	29	CO	co	NN
cord-001859-d62iuk72	673	30	2	2	CD
cord-001859-d62iuk72	673	31	at	at	IN
cord-001859-d62iuk72	673	32	37	37	CD
cord-001859-d62iuk72	673	33	°	°	NN
cord-001859-d62iuk72	673	34	C	c	NN
cord-001859-d62iuk72	673	35	.	.	.
cord-001859-d62iuk72	674	1	Absorbance	Absorbance	NNP
cord-001859-d62iuk72	674	2	was	be	VBD
cord-001859-d62iuk72	674	3	measured	measure	VBN
cord-001859-d62iuk72	674	4	at	at	IN
cord-001859-d62iuk72	674	5	490	490	CD
cord-001859-d62iuk72	674	6	nm	nm	NN
cord-001859-d62iuk72	674	7	using	use	VBG
cord-001859-d62iuk72	674	8	an	an	DT
cord-001859-d62iuk72	674	9	Infinite	Infinite	NNP
cord-001859-d62iuk72	674	10	F50	F50	NNP
cord-001859-d62iuk72	674	11	(	(	-LRB-
cord-001859-d62iuk72	674	12	Tecan	Tecan	NNP
cord-001859-d62iuk72	674	13	)	)	-RRB-
cord-001859-d62iuk72	674	14	plate	plate	NN
cord-001859-d62iuk72	674	15	reader	reader	NN
cord-001859-d62iuk72	674	16	.	.	.
cord-001859-d62iuk72	675	1	Background	background	NN
cord-001859-d62iuk72	675	2	control	control	NN
cord-001859-d62iuk72	675	3	had	have	VBD
cord-001859-d62iuk72	675	4	culture	culture	NN
cord-001859-d62iuk72	675	5	medium	medium	NN
cord-001859-d62iuk72	675	6	without	without	IN
cord-001859-d62iuk72	675	7	cells	cell	NNS
cord-001859-d62iuk72	675	8	and	and	CC
cord-001859-d62iuk72	675	9	the	the	DT
cord-001859-d62iuk72	675	10	signal	signal	NN
cord-001859-d62iuk72	675	11	from	from	IN
cord-001859-d62iuk72	675	12	this	this	DT
cord-001859-d62iuk72	675	13	was	be	VBD
cord-001859-d62iuk72	675	14	subtracted	subtract	VBN
cord-001859-d62iuk72	675	15	to	to	IN
cord-001859-d62iuk72	675	16	all	all	DT
cord-001859-d62iuk72	675	17	other	other	JJ
cord-001859-d62iuk72	675	18	absorbance	absorbance	NN
cord-001859-d62iuk72	675	19	values	value	NNS
cord-001859-d62iuk72	675	20	.	.	.
cord-001859-d62iuk72	676	1	This	this	DT
cord-001859-d62iuk72	676	2	assay	assay	NN
cord-001859-d62iuk72	676	3	allows	allow	VBZ
cord-001859-d62iuk72	676	4	evaluation	evaluation	NN
cord-001859-d62iuk72	676	5	of	of	IN
cord-001859-d62iuk72	676	6	viability	viability	NN
cord-001859-d62iuk72	676	7	,	,	,
cord-001859-d62iuk72	676	8	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	676	9	and	and	CC
cord-001859-d62iuk72	676	10	effector	effector	NN
cord-001859-d62iuk72	676	11	caspases	caspase	NNS
cord-001859-d62iuk72	676	12	activation	activation	NN
cord-001859-d62iuk72	676	13	within	within	IN
cord-001859-d62iuk72	676	14	a	a	DT
cord-001859-d62iuk72	676	15	single	single	JJ
cord-001859-d62iuk72	676	16	assay	assay	NN
cord-001859-d62iuk72	676	17	well	well	RB
cord-001859-d62iuk72	676	18	.	.	.
cord-001859-d62iuk72	677	1	The	the	DT
cord-001859-d62iuk72	677	2	assay	assay	NN
cord-001859-d62iuk72	677	3	was	be	VBD
cord-001859-d62iuk72	677	4	carried	carry	VBN
cord-001859-d62iuk72	677	5	out	out	RP
cord-001859-d62iuk72	677	6	as	as	IN
cord-001859-d62iuk72	677	7	specified	specify	VBN
cord-001859-d62iuk72	677	8	on	on	IN
cord-001859-d62iuk72	677	9	the	the	DT
cord-001859-d62iuk72	677	10	supplier	supplier	NN
cord-001859-d62iuk72	677	11	's	's	POS
cord-001859-d62iuk72	677	12	manual	manual	NN
cord-001859-d62iuk72	677	13	.	.	.
cord-001859-d62iuk72	678	1	20,000	20,000	CD
cord-001859-d62iuk72	678	2	TREx	TREx	NNS
cord-001859-d62iuk72	678	3	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	678	4	cells	cell	NNS
cord-001859-d62iuk72	678	5	or	or	CC
cord-001859-d62iuk72	678	6	10,000	10,000	CD
cord-001859-d62iuk72	678	7	HEK-293	hek-293	JJ
cord-001859-d62iuk72	678	8	T	t	NN
cord-001859-d62iuk72	678	9	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	678	10	cells	cell	NNS
cord-001859-d62iuk72	678	11	were	be	VBD
cord-001859-d62iuk72	678	12	seeded	seed	VBN
cord-001859-d62iuk72	678	13	in	in	IN
cord-001859-d62iuk72	678	14	triplicate	triplicate	NN
cord-001859-d62iuk72	678	15	in	in	IN
cord-001859-d62iuk72	678	16	tissue	tissue	NN
cord-001859-d62iuk72	678	17	culture	culture	NN
cord-001859-d62iuk72	678	18	treated	treat	VBN
cord-001859-d62iuk72	678	19	black	black	JJ
cord-001859-d62iuk72	678	20	microplates	microplate	NNS
cord-001859-d62iuk72	678	21	(	(	-LRB-
cord-001859-d62iuk72	678	22	Greiner	Greiner	NNP
cord-001859-d62iuk72	678	23	Bio	Bio	NNP
cord-001859-d62iuk72	678	24	-	-	HYPH
cord-001859-d62iuk72	678	25	One	One	NNP
cord-001859-d62iuk72	678	26	)	)	-RRB-
cord-001859-d62iuk72	678	27	.	.	.
cord-001859-d62iuk72	679	1	No	no	DT
cord-001859-d62iuk72	679	2	-	-	HYPH
cord-001859-d62iuk72	679	3	cell	cell	NN
cord-001859-d62iuk72	679	4	control	control	NN
cord-001859-d62iuk72	679	5	(	(	-LRB-
cord-001859-d62iuk72	679	6	background	background	NN
cord-001859-d62iuk72	679	7	)	)	-RRB-
cord-001859-d62iuk72	679	8	contained	contain	VBN
cord-001859-d62iuk72	679	9	only	only	JJ
cord-001859-d62iuk72	679	10	culture	culture	NN
cord-001859-d62iuk72	679	11	medium	medium	NN
cord-001859-d62iuk72	679	12	and	and	CC
cord-001859-d62iuk72	679	13	the	the	DT
cord-001859-d62iuk72	679	14	signal	signal	NN
cord-001859-d62iuk72	679	15	from	from	IN
cord-001859-d62iuk72	679	16	this	this	DT
cord-001859-d62iuk72	679	17	was	be	VBD
cord-001859-d62iuk72	679	18	subtracted	subtract	VBN
cord-001859-d62iuk72	679	19	to	to	IN
cord-001859-d62iuk72	679	20	all	all	DT
cord-001859-d62iuk72	679	21	other	other	JJ
cord-001859-d62iuk72	679	22	absorbance	absorbance	NN
cord-001859-d62iuk72	679	23	and	and	CC
cord-001859-d62iuk72	679	24	luminescence	luminescence	NN
cord-001859-d62iuk72	679	25	values	value	NNS
cord-001859-d62iuk72	679	26	.	.	.
cord-001859-d62iuk72	680	1	Fluorescence	fluorescence	NN
cord-001859-d62iuk72	680	2	and	and	CC
cord-001859-d62iuk72	680	3	luminescence	luminescence	NN
cord-001859-d62iuk72	680	4	readings	reading	NNS
cord-001859-d62iuk72	680	5	were	be	VBD
cord-001859-d62iuk72	680	6	collected	collect	VBN
cord-001859-d62iuk72	680	7	using	use	VBG
cord-001859-d62iuk72	680	8	a	a	DT
cord-001859-d62iuk72	680	9	GloMax	GloMax	NNP
cord-001859-d62iuk72	680	10	System	System	NNP
cord-001859-d62iuk72	680	11	(	(	-LRB-
cord-001859-d62iuk72	680	12	Promega	Promega	NNP
cord-001859-d62iuk72	680	13	)	)	-RRB-
cord-001859-d62iuk72	680	14	(	(	-LRB-
cord-001859-d62iuk72	680	15	kindly	kindly	RB
cord-001859-d62iuk72	680	16	provided	provide	VBN
cord-001859-d62iuk72	680	17	by	by	IN
cord-001859-d62iuk72	680	18	Dr.	Dr.	NNP
cord-001859-d62iuk72	680	19	John	John	NNP
cord-001859-d62iuk72	680	20	Boyle	Boyle	NNP
cord-001859-d62iuk72	680	21	,	,	,
cord-001859-d62iuk72	680	22	University	University	NNP
cord-001859-d62iuk72	680	23	of	of	IN
cord-001859-d62iuk72	680	24	Leeds	Leeds	NNP
cord-001859-d62iuk72	680	25	,	,	,
cord-001859-d62iuk72	680	26	UK	UK	NNP
cord-001859-d62iuk72	680	27	)	)	-RRB-
cord-001859-d62iuk72	680	28	.	.	.
cord-001859-d62iuk72	681	1	Luciferase	luciferase	NN
cord-001859-d62iuk72	681	2	activity	activity	NN
cord-001859-d62iuk72	681	3	was	be	VBD
cord-001859-d62iuk72	681	4	detected	detect	VBN
cord-001859-d62iuk72	681	5	using	use	VBG
cord-001859-d62iuk72	681	6	the	the	DT
cord-001859-d62iuk72	681	7	Dual	Dual	NNP
cord-001859-d62iuk72	681	8	-	-	HYPH
cord-001859-d62iuk72	681	9	Luciferase	Luciferase	NNP
cord-001859-d62iuk72	681	10	Reporter	reporter	NN
cord-001859-d62iuk72	681	11	Assay	Assay	NNP
cord-001859-d62iuk72	681	12	System	System	NNP
cord-001859-d62iuk72	681	13	(	(	-LRB-
cord-001859-d62iuk72	681	14	Promega	Promega	NNP
cord-001859-d62iuk72	681	15	)	)	-RRB-
cord-001859-d62iuk72	681	16	as	as	IN
cord-001859-d62iuk72	681	17	previously	previously	RB
cord-001859-d62iuk72	681	18	described	describe	VBN
cord-001859-d62iuk72	681	19	[	[	-LRB-
cord-001859-d62iuk72	681	20	107	107	CD
cord-001859-d62iuk72	681	21	]	]	-RRB-
cord-001859-d62iuk72	681	22	.	.	.
cord-001859-d62iuk72	682	1	HEK-293	HEK-293	NNP
cord-001859-d62iuk72	683	1	T	t	NN
cord-001859-d62iuk72	683	2	cells	cell	NNS
cord-001859-d62iuk72	683	3	were	be	VBD
cord-001859-d62iuk72	683	4	seeded	seed	VBN
cord-001859-d62iuk72	683	5	in	in	IN
cord-001859-d62iuk72	683	6	triplicate	triplicate	NN
cord-001859-d62iuk72	683	7	in	in	IN
cord-001859-d62iuk72	683	8	flat	flat	JJ
cord-001859-d62iuk72	683	9	96-well	96-well	CD
cord-001859-d62iuk72	683	10	culture	culture	NN
cord-001859-d62iuk72	683	11	plate	plate	NN
cord-001859-d62iuk72	683	12	(	(	-LRB-
cord-001859-d62iuk72	683	13	Corning	Corning	NNP
cord-001859-d62iuk72	683	14	)	)	-RRB-
cord-001859-d62iuk72	683	15	at	at	IN
cord-001859-d62iuk72	683	16	a	a	DT
cord-001859-d62iuk72	683	17	density	density	NN
cord-001859-d62iuk72	683	18	of	of	IN
cord-001859-d62iuk72	683	19	10,000	10,000	CD
cord-001859-d62iuk72	683	20	cells	cell	NNS
cord-001859-d62iuk72	683	21	per	per	IN
cord-001859-d62iuk72	683	22	well	well	RB
cord-001859-d62iuk72	683	23	.	.	.
cord-001859-d62iuk72	684	1	Following	follow	VBG
cord-001859-d62iuk72	684	2	the	the	DT
cord-001859-d62iuk72	684	3	respective	respective	JJ
cord-001859-d62iuk72	684	4	plasmid	plasmid	NN
cord-001859-d62iuk72	684	5	transfections	transfection	NNS
cord-001859-d62iuk72	684	6	and	and	CC
cord-001859-d62iuk72	684	7	inhibitor	inhibitor	NN
cord-001859-d62iuk72	684	8	exposure	exposure	NN
cord-001859-d62iuk72	684	9	,	,	,
cord-001859-d62iuk72	684	10	media	medium	NNS
cord-001859-d62iuk72	684	11	was	be	VBD
cord-001859-d62iuk72	684	12	removed	remove	VBN
cord-001859-d62iuk72	684	13	from	from	IN
cord-001859-d62iuk72	684	14	the	the	DT
cord-001859-d62iuk72	684	15	culture	culture	NN
cord-001859-d62iuk72	684	16	wells	well	NNS
cord-001859-d62iuk72	684	17	and	and	CC
cord-001859-d62iuk72	684	18	cells	cell	NNS
cord-001859-d62iuk72	684	19	washed	wash	VBD
cord-001859-d62iuk72	684	20	gently	gently	RB
cord-001859-d62iuk72	684	21	with	with	IN
cord-001859-d62iuk72	684	22	100	100	CD
cord-001859-d62iuk72	684	23	μl	μl	XX
cord-001859-d62iuk72	685	1	PBS	PBS	NNP
cord-001859-d62iuk72	685	2	.	.	.
cord-001859-d62iuk72	686	1	30	30	CD
cord-001859-d62iuk72	686	2	μl	μl	IN
cord-001859-d62iuk72	686	3	1x	1x	JJ
cord-001859-d62iuk72	686	4	passive	passive	JJ
cord-001859-d62iuk72	686	5	lysis	lysis	NN
cord-001859-d62iuk72	686	6	buffer	buffer	NN
cord-001859-d62iuk72	686	7	was	be	VBD
cord-001859-d62iuk72	686	8	added	add	VBN
cord-001859-d62iuk72	686	9	to	to	IN
cord-001859-d62iuk72	686	10	the	the	DT
cord-001859-d62iuk72	686	11	cell	cell	NN
cord-001859-d62iuk72	686	12	monolayer	monolayer	NN
cord-001859-d62iuk72	686	13	which	which	WDT
cord-001859-d62iuk72	686	14	was	be	VBD
cord-001859-d62iuk72	686	15	rocked	rock	VBN
cord-001859-d62iuk72	686	16	for	for	IN
cord-001859-d62iuk72	686	17	15	15	CD
cord-001859-d62iuk72	686	18	min	min	NN
cord-001859-d62iuk72	686	19	and	and	CC
cord-001859-d62iuk72	686	20	then	then	RB
cord-001859-d62iuk72	686	21	20	20	CD
cord-001859-d62iuk72	686	22	μl	μl	NN
cord-001859-d62iuk72	686	23	of	of	IN
cord-001859-d62iuk72	686	24	each	each	DT
cord-001859-d62iuk72	686	25	lysate	lysate	NN
cord-001859-d62iuk72	686	26	was	be	VBD
cord-001859-d62iuk72	686	27	transferred	transfer	VBN
cord-001859-d62iuk72	686	28	to	to	IN
cord-001859-d62iuk72	686	29	tissue	tissue	NN
cord-001859-d62iuk72	686	30	culture	culture	NN
cord-001859-d62iuk72	686	31	treated	treat	VBN
cord-001859-d62iuk72	686	32	white	white	JJ
cord-001859-d62iuk72	686	33	microplates	microplate	NNS
cord-001859-d62iuk72	686	34	(	(	-LRB-
cord-001859-d62iuk72	686	35	Greiner	Greiner	NNP
cord-001859-d62iuk72	686	36	Bio	Bio	NNP
cord-001859-d62iuk72	686	37	-	-	HYPH
cord-001859-d62iuk72	686	38	One	One	NNP
cord-001859-d62iuk72	686	39	)	)	-RRB-
cord-001859-d62iuk72	686	40	.	.	.
cord-001859-d62iuk72	687	1	Luciferase	luciferase	NN
cord-001859-d62iuk72	687	2	measurements	measurement	NNS
cord-001859-d62iuk72	687	3	were	be	VBD
cord-001859-d62iuk72	687	4	carried	carry	VBN
cord-001859-d62iuk72	687	5	out	out	RP
cord-001859-d62iuk72	687	6	in	in	IN
cord-001859-d62iuk72	687	7	a	a	DT
cord-001859-d62iuk72	687	8	FLUOstar	FLUOstar	NNP
cord-001859-d62iuk72	687	9	Optima	Optima	NNP
cord-001859-d62iuk72	687	10	microplate	microplate	NN
cord-001859-d62iuk72	687	11	reader	reader	NN
cord-001859-d62iuk72	687	12	(	(	-LRB-
cord-001859-d62iuk72	687	13	BMG	BMG	NNP
cord-001859-d62iuk72	687	14	Labtech	Labtech	NNP
cord-001859-d62iuk72	687	15	Ltd	Ltd	NNP
cord-001859-d62iuk72	687	16	)	)	-RRB-
cord-001859-d62iuk72	687	17	,	,	,
cord-001859-d62iuk72	687	18	with	with	IN
cord-001859-d62iuk72	687	19	injectors	injector	NNS
cord-001859-d62iuk72	687	20	1	1	CD
cord-001859-d62iuk72	687	21	and	and	CC
cord-001859-d62iuk72	687	22	2	2	CD
cord-001859-d62iuk72	687	23	being	be	VBG
cord-001859-d62iuk72	687	24	used	use	VBN
cord-001859-d62iuk72	687	25	to	to	TO
cord-001859-d62iuk72	687	26	dispense	dispense	VB
cord-001859-d62iuk72	687	27	50	50	CD
cord-001859-d62iuk72	687	28	μl	μl	NN
cord-001859-d62iuk72	687	29	of	of	IN
cord-001859-d62iuk72	687	30	Luciferase	Luciferase	NNP
cord-001859-d62iuk72	687	31	Assay	Assay	NNP
cord-001859-d62iuk72	687	32	Reagent	Reagent	NNP
cord-001859-d62iuk72	687	33	II	II	NNP
cord-001859-d62iuk72	687	34	and	and	CC
cord-001859-d62iuk72	687	35	Stop	Stop	NNP
cord-001859-d62iuk72	687	36	&	&	CC
cord-001859-d62iuk72	687	37	Glo	Glo	NNP
cord-001859-d62iuk72	687	38	Reagent	Reagent	NNP
cord-001859-d62iuk72	687	39	respectively	respectively	RB
cord-001859-d62iuk72	687	40	.	.	.
cord-001859-d62iuk72	688	1	Firefly	Firefly	NNP
cord-001859-d62iuk72	688	2	luciferase	luciferase	NN
cord-001859-d62iuk72	688	3	activity	activity	NN
cord-001859-d62iuk72	688	4	was	be	VBD
cord-001859-d62iuk72	688	5	normalized	normalize	VBN
cord-001859-d62iuk72	688	6	to	to	IN
cord-001859-d62iuk72	688	7	Renilla	Renilla	NNP
cord-001859-d62iuk72	688	8	luciferase	luciferase	NN
cord-001859-d62iuk72	688	9	activity	activity	NN
cord-001859-d62iuk72	688	10	.	.	.
cord-001859-d62iuk72	689	1	Formaldehyde	formaldehyde	NN
cord-001859-d62iuk72	689	2	-	-	HYPH
cord-001859-d62iuk72	689	3	crosslinked	crosslinke	VBN
cord-001859-d62iuk72	689	4	chromatin	chromatin	NN
cord-001859-d62iuk72	689	5	was	be	VBD
cord-001859-d62iuk72	689	6	prepared	prepare	VBN
cord-001859-d62iuk72	689	7	using	use	VBG
cord-001859-d62iuk72	689	8	the	the	DT
cord-001859-d62iuk72	689	9	Pierce	Pierce	NNP
cord-001859-d62iuk72	689	10	Chromatin	Chromatin	NNP
cord-001859-d62iuk72	689	11	Prep	Prep	NNP
cord-001859-d62iuk72	689	12	Module	Module	NNP
cord-001859-d62iuk72	689	13	(	(	-LRB-
cord-001859-d62iuk72	689	14	Thermo	Thermo	NNP
cord-001859-d62iuk72	689	15	Scientific	Scientific	NNP
cord-001859-d62iuk72	689	16	)	)	-RRB-
cord-001859-d62iuk72	689	17	following	follow	VBG
cord-001859-d62iuk72	689	18	the	the	DT
cord-001859-d62iuk72	689	19	manufacturer	manufacturer	NN
cord-001859-d62iuk72	689	20	's	's	POS
cord-001859-d62iuk72	689	21	protocol	protocol	NN
cord-001859-d62iuk72	689	22	.	.	.
cord-001859-d62iuk72	690	1	2	2	CD
cord-001859-d62iuk72	690	2	x	x	SYM
cord-001859-d62iuk72	690	3	10	10	CD
cord-001859-d62iuk72	690	4	6	6	CD
cord-001859-d62iuk72	690	5	cells	cell	NNS
cord-001859-d62iuk72	690	6	were	be	VBD
cord-001859-d62iuk72	690	7	used	use	VBN
cord-001859-d62iuk72	690	8	per	per	IN
cord-001859-d62iuk72	690	9	experimental	experimental	JJ
cord-001859-d62iuk72	690	10	sample	sample	NN
cord-001859-d62iuk72	690	11	and	and	CC
cord-001859-d62iuk72	690	12	digested	digest	VBN
cord-001859-d62iuk72	690	13	with	with	IN
cord-001859-d62iuk72	690	14	six	six	CD
cord-001859-d62iuk72	690	15	units	unit	NNS
cord-001859-d62iuk72	690	16	of	of	IN
cord-001859-d62iuk72	690	17	micrococcal	micrococcal	NNP
cord-001859-d62iuk72	690	18	nuclease	nuclease	FW
cord-001859-d62iuk72	690	19	(	(	-LRB-
cord-001859-d62iuk72	690	20	MNase	MNase	NNP
cord-001859-d62iuk72	690	21	)	)	-RRB-
cord-001859-d62iuk72	690	22	per	per	IN
cord-001859-d62iuk72	690	23	100	100	CD
cord-001859-d62iuk72	690	24	μl	μl	NN
cord-001859-d62iuk72	690	25	of	of	IN
cord-001859-d62iuk72	690	26	MNase	MNase	NNP
cord-001859-d62iuk72	690	27	Digestion	digestion	NN
cord-001859-d62iuk72	690	28	buffer	buffer	NN
cord-001859-d62iuk72	690	29	in	in	IN
cord-001859-d62iuk72	690	30	a	a	DT
cord-001859-d62iuk72	690	31	37	37	CD
cord-001859-d62iuk72	690	32	°	°	NN
cord-001859-d62iuk72	690	33	C	c	NN
cord-001859-d62iuk72	690	34	water	water	NN
cord-001859-d62iuk72	690	35	bath	bath	NN
cord-001859-d62iuk72	690	36	for	for	IN
cord-001859-d62iuk72	690	37	15	15	CD
cord-001859-d62iuk72	690	38	min	min	NN
cord-001859-d62iuk72	690	39	.	.	.
cord-001859-d62iuk72	691	1	These	these	DT
cord-001859-d62iuk72	691	2	conditions	condition	NNS
cord-001859-d62iuk72	691	3	resulted	result	VBD
cord-001859-d62iuk72	691	4	in	in	IN
cord-001859-d62iuk72	691	5	optimal	optimal	JJ
cord-001859-d62iuk72	691	6	sheared	shear	VBN
cord-001859-d62iuk72	691	7	chromatin	chromatin	NN
cord-001859-d62iuk72	691	8	with	with	IN
cord-001859-d62iuk72	691	9	most	most	JJS
cord-001859-d62iuk72	691	10	chromatin	chromatin	NN
cord-001859-d62iuk72	691	11	fragments	fragment	NNS
cord-001859-d62iuk72	691	12	ranging	range	VBG
cord-001859-d62iuk72	691	13	from	from	IN
cord-001859-d62iuk72	691	14	150	150	CD
cord-001859-d62iuk72	691	15	-	-	SYM
cord-001859-d62iuk72	691	16	300	300	CD
cord-001859-d62iuk72	691	17	base	base	NN
cord-001859-d62iuk72	691	18	pairs	pair	NNS
cord-001859-d62iuk72	691	19	.	.	.
cord-001859-d62iuk72	692	1	Immunoprecipitations	immunoprecipitation	NNS
cord-001859-d62iuk72	692	2	were	be	VBD
cord-001859-d62iuk72	692	3	carried	carry	VBN
cord-001859-d62iuk72	692	4	out	out	RP
cord-001859-d62iuk72	692	5	using	use	VBG
cord-001859-d62iuk72	692	6	EZ	EZ	NNP
cord-001859-d62iuk72	692	7	-	-	HYPH
cord-001859-d62iuk72	692	8	ChIP	ChIP	NNP
cord-001859-d62iuk72	692	9	kit	kit	NN
cord-001859-d62iuk72	692	10	(	(	-LRB-
cord-001859-d62iuk72	692	11	Millipore	Millipore	NNP
cord-001859-d62iuk72	692	12	)	)	-RRB-
cord-001859-d62iuk72	692	13	according	accord	VBG
cord-001859-d62iuk72	692	14	to	to	IN
cord-001859-d62iuk72	692	15	the	the	DT
cord-001859-d62iuk72	692	16	supplier	supplier	NN
cord-001859-d62iuk72	692	17	's	's	POS
cord-001859-d62iuk72	692	18	instructions	instruction	NNS
cord-001859-d62iuk72	692	19	and	and	CC
cord-001859-d62iuk72	692	20	as	as	RB
cord-001859-d62iuk72	692	21	previously	previously	RB
cord-001859-d62iuk72	692	22	described	describe	VBN
cord-001859-d62iuk72	692	23	[	[	-LRB-
cord-001859-d62iuk72	692	24	44	44	CD
cord-001859-d62iuk72	692	25	]	]	-RRB-
cord-001859-d62iuk72	692	26	.	.	.
cord-001859-d62iuk72	693	1	Immunoprecipitations	immunoprecipitation	NNS
cord-001859-d62iuk72	693	2	were	be	VBD
cord-001859-d62iuk72	693	3	done	do	VBN
cord-001859-d62iuk72	693	4	overnight	overnight	RB
cord-001859-d62iuk72	693	5	at	at	IN
cord-001859-d62iuk72	693	6	4	4	CD
cord-001859-d62iuk72	693	7	°	°	NN
cord-001859-d62iuk72	693	8	C	c	NN
cord-001859-d62iuk72	693	9	and	and	CC
cord-001859-d62iuk72	693	10	contained	contain	VBD
cord-001859-d62iuk72	693	11	50	50	CD
cord-001859-d62iuk72	693	12	μl	μl	NN
cord-001859-d62iuk72	693	13	of	of	IN
cord-001859-d62iuk72	693	14	digested	digest	VBN
cord-001859-d62iuk72	693	15	chromatin	chromatin	NN
cord-001859-d62iuk72	693	16	(	(	-LRB-
cord-001859-d62iuk72	693	17	2	2	CD
cord-001859-d62iuk72	693	18	x	x	SYM
cord-001859-d62iuk72	693	19	10	10	CD
cord-001859-d62iuk72	693	20	6	6	CD
cord-001859-d62iuk72	693	21	cells	cell	NNS
cord-001859-d62iuk72	693	22	)	)	-RRB-
cord-001859-d62iuk72	693	23	,	,	,
cord-001859-d62iuk72	693	24	450	450	CD
cord-001859-d62iuk72	693	25	μl	μl	NN
cord-001859-d62iuk72	693	26	of	of	IN
cord-001859-d62iuk72	693	27	ChIP	chip	NN
cord-001859-d62iuk72	693	28	dilution	dilution	NN
cord-001859-d62iuk72	693	29	buffer	buffer	NN
cord-001859-d62iuk72	693	30	and	and	CC
cord-001859-d62iuk72	693	31	1.5	1.5	CD
cord-001859-d62iuk72	693	32	μg	μg	NNS
cord-001859-d62iuk72	693	33	of	of	IN
cord-001859-d62iuk72	693	34	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	693	35	antibody	antibody	NN
cord-001859-d62iuk72	693	36	(	(	-LRB-
cord-001859-d62iuk72	693	37	clone	clone	VB
cord-001859-d62iuk72	693	38	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	693	39	)	)	-RRB-
cord-001859-d62iuk72	694	1	(	(	-LRB-
cord-001859-d62iuk72	694	2	Millipore	Millipore	NNP
cord-001859-d62iuk72	694	3	)	)	-RRB-
cord-001859-d62iuk72	694	4	or	or	CC
cord-001859-d62iuk72	694	5	isotype	isotype	NN
cord-001859-d62iuk72	694	6	antibody	antibody	NN
cord-001859-d62iuk72	694	7	,	,	,
cord-001859-d62iuk72	694	8	normal	normal	JJ
cord-001859-d62iuk72	694	9	mouse	mouse	NN
cord-001859-d62iuk72	694	10	IgG	igg	NN
cord-001859-d62iuk72	694	11	(	(	-LRB-
cord-001859-d62iuk72	694	12	Millipore	Millipore	NNP
cord-001859-d62iuk72	694	13	)	)	-RRB-
cord-001859-d62iuk72	694	14	.	.	.
cord-001859-d62iuk72	695	1	Both	both	DT
cord-001859-d62iuk72	695	2	antibodies	antibody	NNS
cord-001859-d62iuk72	695	3	were	be	VBD
cord-001859-d62iuk72	695	4	provided	provide	VBN
cord-001859-d62iuk72	695	5	with	with	IN
cord-001859-d62iuk72	695	6	the	the	DT
cord-001859-d62iuk72	695	7	EZ	EZ	NNP
cord-001859-d62iuk72	695	8	-	-	HYPH
cord-001859-d62iuk72	695	9	ChIP	ChIP	NNP
cord-001859-d62iuk72	695	10	kit	kit	NN
cord-001859-d62iuk72	695	11	.	.	.
cord-001859-d62iuk72	696	1	Prior	prior	RB
cord-001859-d62iuk72	696	2	to	to	IN
cord-001859-d62iuk72	696	3	qPCR	qPCR	NNP
cord-001859-d62iuk72	696	4	analysis	analysis	NN
cord-001859-d62iuk72	696	5	,	,	,
cord-001859-d62iuk72	696	6	eluted	eluted	JJ
cord-001859-d62iuk72	696	7	DNA	DNA	NNP
cord-001859-d62iuk72	696	8	was	be	VBD
cord-001859-d62iuk72	696	9	subjected	subject	VBN
cord-001859-d62iuk72	696	10	to	to	IN
cord-001859-d62iuk72	696	11	a	a	DT
cord-001859-d62iuk72	696	12	DNA	dna	NN
cord-001859-d62iuk72	696	13	clean	clean	JJ
cord-001859-d62iuk72	696	14	up	up	RP
cord-001859-d62iuk72	696	15	step	step	NN
cord-001859-d62iuk72	696	16	using	use	VBG
cord-001859-d62iuk72	696	17	UltraClean	UltraClean	NNP
cord-001859-d62iuk72	696	18	PCR	PCR	NNP
cord-001859-d62iuk72	696	19	Clean	clean	VB
cord-001859-d62iuk72	696	20	-	-	HYPH
cord-001859-d62iuk72	696	21	Up	up	NN
cord-001859-d62iuk72	696	22	Kit	kit	NN
cord-001859-d62iuk72	696	23	(	(	-LRB-
cord-001859-d62iuk72	696	24	Mo	Mo	NNP
cord-001859-d62iuk72	696	25	Bio	Bio	NNP
cord-001859-d62iuk72	696	26	Laboratories	Laboratories	NNP
cord-001859-d62iuk72	696	27	)	)	-RRB-
cord-001859-d62iuk72	696	28	according	accord	VBG
cord-001859-d62iuk72	696	29	to	to	IN
cord-001859-d62iuk72	696	30	the	the	DT
cord-001859-d62iuk72	696	31	supplied	supply	VBN
cord-001859-d62iuk72	696	32	protocol	protocol	NN
cord-001859-d62iuk72	696	33	with	with	IN
cord-001859-d62iuk72	696	34	the	the	DT
cord-001859-d62iuk72	696	35	exception	exception	NN
cord-001859-d62iuk72	696	36	of	of	IN
cord-001859-d62iuk72	696	37	using	use	VBG
cord-001859-d62iuk72	696	38	500	500	CD
cord-001859-d62iuk72	696	39	μl	μl	NN
cord-001859-d62iuk72	696	40	of	of	IN
cord-001859-d62iuk72	696	41	SpinClean	SpinClean	NNP
cord-001859-d62iuk72	696	42	buffer	buffer	NN
cord-001859-d62iuk72	696	43	instead	instead	RB
cord-001859-d62iuk72	696	44	of	of	IN
cord-001859-d62iuk72	696	45	300	300	CD
cord-001859-d62iuk72	696	46	μl	μl	UH
cord-001859-d62iuk72	696	47	.	.	.
cord-001859-d62iuk72	697	1	qPCR	qPCR	NNP
cord-001859-d62iuk72	697	2	reactions	reaction	NNS
cord-001859-d62iuk72	697	3	were	be	VBD
cord-001859-d62iuk72	697	4	performed	perform	VBN
cord-001859-d62iuk72	697	5	as	as	IN
cord-001859-d62iuk72	697	6	described	describe	VBN
cord-001859-d62iuk72	697	7	above	above	RB
cord-001859-d62iuk72	697	8	and	and	CC
cord-001859-d62iuk72	697	9	using	use	VBG
cord-001859-d62iuk72	697	10	either	either	CC
cord-001859-d62iuk72	697	11	2	2	CD
cord-001859-d62iuk72	697	12	μl	μl	NN
cord-001859-d62iuk72	697	13	of	of	IN
cord-001859-d62iuk72	697	14	ChIP'ed	ChIP'ed	HYPH
cord-001859-d62iuk72	697	15	DNA	DNA	NNP
cord-001859-d62iuk72	697	16	or	or	CC
cord-001859-d62iuk72	697	17	2	2	CD
cord-001859-d62iuk72	697	18	μl	μl	NN
cord-001859-d62iuk72	697	19	of	of	IN
cord-001859-d62iuk72	697	20	input	input	NN
cord-001859-d62iuk72	697	21	DNA	dna	NN
cord-001859-d62iuk72	697	22	as	as	IN
cord-001859-d62iuk72	697	23	template	template	NN
cord-001859-d62iuk72	697	24	.	.	.
cord-001859-d62iuk72	698	1	siRNA	siRNA	NNP
cord-001859-d62iuk72	699	1	Knockdown	Knockdown	NNP
cord-001859-d62iuk72	699	2	HEK-293	hek-293	JJ
cord-001859-d62iuk72	699	3	T	t	NN
cord-001859-d62iuk72	699	4	rKSHV.219	rKSHV.219	,
cord-001859-d62iuk72	699	5	cells	cell	NNS
cord-001859-d62iuk72	699	6	seeded	seed	VBN
cord-001859-d62iuk72	699	7	on	on	IN
cord-001859-d62iuk72	699	8	12-well	12-well	CD
cord-001859-d62iuk72	699	9	plates	plate	NNS
cord-001859-d62iuk72	699	10	were	be	VBD
cord-001859-d62iuk72	699	11	reverse	reverse	JJ
cord-001859-d62iuk72	699	12	transfected	transfecte	VBN
cord-001859-d62iuk72	699	13	with	with	IN
cord-001859-d62iuk72	699	14	either	either	DT
cord-001859-d62iuk72	699	15	100	100	CD
cord-001859-d62iuk72	699	16	nM	nm	CD
cord-001859-d62iuk72	699	17	of	of	IN
cord-001859-d62iuk72	699	18	the	the	DT
cord-001859-d62iuk72	699	19	specific	specific	JJ
cord-001859-d62iuk72	699	20	Silencer	Silencer	NNP
cord-001859-d62iuk72	699	21	Select	Select	NNP
cord-001859-d62iuk72	699	22	siRNA	siRNA	NNP
cord-001859-d62iuk72	699	23	(	(	-LRB-
cord-001859-d62iuk72	699	24	Life	Life	NNP
cord-001859-d62iuk72	699	25	Technologies	Technologies	NNPS
cord-001859-d62iuk72	699	26	)	)	-RRB-
cord-001859-d62iuk72	699	27	or	or	CC
cord-001859-d62iuk72	700	1	100	100	CD
cord-001859-d62iuk72	700	2	nM	nM	NNP
cord-001859-d62iuk72	700	3	AllStars	allstars	CD
cord-001859-d62iuk72	700	4	negative	negative	JJ
cord-001859-d62iuk72	700	5	control	control	NN
cord-001859-d62iuk72	701	1	siRNA	siRNA	NNP
cord-001859-d62iuk72	701	2	(	(	-LRB-
cord-001859-d62iuk72	701	3	Qiagen	Qiagen	NNP
cord-001859-d62iuk72	701	4	)	)	-RRB-
cord-001859-d62iuk72	701	5	using	use	VBG
cord-001859-d62iuk72	701	6	7	7	CD
cord-001859-d62iuk72	701	7	μl	μl	NN
cord-001859-d62iuk72	701	8	of	of	IN
cord-001859-d62iuk72	701	9	siPORT	siPORT	NNP
cord-001859-d62iuk72	701	10	NeoFX	NeoFX	NNP
cord-001859-d62iuk72	701	11	transfection	transfection	NN
cord-001859-d62iuk72	701	12	agent	agent	NN
cord-001859-d62iuk72	701	13	(	(	-LRB-
cord-001859-d62iuk72	701	14	Life	Life	NNP
cord-001859-d62iuk72	701	15	Technologies	Technologies	NNPS
cord-001859-d62iuk72	701	16	)	)	-RRB-
cord-001859-d62iuk72	701	17	per	per	IN
cord-001859-d62iuk72	701	18	transfection	transfection	NN
cord-001859-d62iuk72	701	19	.	.	.
cord-001859-d62iuk72	702	1	The	the	DT
cord-001859-d62iuk72	702	2	siRNA	siRNA	NNP
cord-001859-d62iuk72	702	3	ID	ID	NNP
cord-001859-d62iuk72	702	4	for	for	IN
cord-001859-d62iuk72	702	5	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	702	6	and	and	CC
cord-001859-d62iuk72	702	7	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	702	8	were	be	VBD
cord-001859-d62iuk72	702	9	s6985	s6985	VB
cord-001859-d62iuk72	702	10	and	and	CC
cord-001859-d62iuk72	702	11	s6968	s6968	NNP
cord-001859-d62iuk72	702	12	respectively	respectively	RB
cord-001859-d62iuk72	702	13	.	.	.
cord-001859-d62iuk72	703	1	s6968	s6968	NNP
cord-001859-d62iuk72	703	2	siRNA	siRNA	NNP
cord-001859-d62iuk72	703	3	targets	target	VBZ
cord-001859-d62iuk72	703	4	the	the	DT
cord-001859-d62iuk72	703	5	two	two	CD
cord-001859-d62iuk72	703	6	major	major	JJ
cord-001859-d62iuk72	703	7	iHsp70	iHsp70	``
cord-001859-d62iuk72	703	8	proteins	protein	NNS
cord-001859-d62iuk72	703	9	(	(	-LRB-
cord-001859-d62iuk72	703	10	HSP70	HSP70	NNP
cord-001859-d62iuk72	703	11	-	-	HYPH
cord-001859-d62iuk72	703	12	1	1	NNP
cord-001859-d62iuk72	703	13	and	and	CC
cord-001859-d62iuk72	703	14	HSP70	HSP70	NNP
cord-001859-d62iuk72	703	15	-	-	HYPH
cord-001859-d62iuk72	703	16	2	2	CD
cord-001859-d62iuk72	703	17	)	)	-RRB-
cord-001859-d62iuk72	703	18	.	.	.
cord-001859-d62iuk72	704	1	Two	two	CD
cord-001859-d62iuk72	704	2	days	day	NNS
cord-001859-d62iuk72	704	3	post	post	NN
cord-001859-d62iuk72	704	4	-	-	NN
cord-001859-d62iuk72	704	5	transfection	transfection	JJ
cord-001859-d62iuk72	704	6	,	,	,
cord-001859-d62iuk72	704	7	cells	cell	NNS
cord-001859-d62iuk72	704	8	were	be	VBD
cord-001859-d62iuk72	704	9	transfected	transfecte	VBN
cord-001859-d62iuk72	704	10	again	again	RB
cord-001859-d62iuk72	704	11	in	in	IN
cord-001859-d62iuk72	704	12	the	the	DT
cord-001859-d62iuk72	704	13	same	same	JJ
cord-001859-d62iuk72	704	14	manner	manner	NN
cord-001859-d62iuk72	704	15	.	.	.
cord-001859-d62iuk72	705	1	Four	four	CD
cord-001859-d62iuk72	705	2	days	day	NNS
cord-001859-d62iuk72	705	3	after	after	IN
cord-001859-d62iuk72	705	4	the	the	DT
cord-001859-d62iuk72	705	5	first	first	JJ
cord-001859-d62iuk72	705	6	transfection	transfection	NN
cord-001859-d62iuk72	705	7	,	,	,
cord-001859-d62iuk72	705	8	cells	cell	NNS
cord-001859-d62iuk72	705	9	were	be	VBD
cord-001859-d62iuk72	705	10	reactivated	reactivate	VBN
cord-001859-d62iuk72	705	11	and	and	CC
cord-001859-d62iuk72	705	12	incubated	incubate	VBN
cord-001859-d62iuk72	705	13	for	for	IN
cord-001859-d62iuk72	705	14	the	the	DT
cord-001859-d62iuk72	705	15	desired	desire	VBN
cord-001859-d62iuk72	705	16	time	time	NN
cord-001859-d62iuk72	705	17	.	.	.
cord-001859-d62iuk72	706	1	Proteins	protein	NNS
cord-001859-d62iuk72	706	2	and	and	CC
cord-001859-d62iuk72	706	3	total	total	JJ
cord-001859-d62iuk72	706	4	RNA	RNA	NNP
cord-001859-d62iuk72	706	5	were	be	VBD
cord-001859-d62iuk72	706	6	isolated	isolate	VBN
cord-001859-d62iuk72	706	7	with	with	IN
cord-001859-d62iuk72	706	8	TRIzol	TRIzol	NNP
cord-001859-d62iuk72	706	9	(	(	-LRB-
cord-001859-d62iuk72	706	10	Life	Life	NNP
cord-001859-d62iuk72	706	11	Technologies	Technologies	NNPS
cord-001859-d62iuk72	706	12	)	)	-RRB-
cord-001859-d62iuk72	706	13	and	and	CC
cord-001859-d62iuk72	706	14	subsequent	subsequent	JJ
cord-001859-d62iuk72	706	15	Western	western	JJ
cord-001859-d62iuk72	706	16	blot	blot	NN
cord-001859-d62iuk72	706	17	and	and	CC
cord-001859-d62iuk72	706	18	qRT	qRT	NNP
cord-001859-d62iuk72	706	19	-	-	HYPH
cord-001859-d62iuk72	706	20	PCR	PCR	NNP
cord-001859-d62iuk72	706	21	were	be	VBD
cord-001859-d62iuk72	706	22	performed	perform	VBN
cord-001859-d62iuk72	706	23	.	.	.
cord-001859-d62iuk72	707	1	8	8	CD
cord-001859-d62iuk72	707	2	×	×	NN
cord-001859-d62iuk72	707	3	10	10	CD
cord-001859-d62iuk72	707	4	6	6	CD
cord-001859-d62iuk72	707	5	TREx	TREx	NNS
cord-001859-d62iuk72	707	6	BCBL1-RTA	bcbl1-rta	NN
cord-001859-d62iuk72	707	7	cells	cell	NNS
cord-001859-d62iuk72	707	8	were	be	VBD
cord-001859-d62iuk72	707	9	transfected	transfecte	VBN
cord-001859-d62iuk72	707	10	once	once	RB
cord-001859-d62iuk72	707	11	with	with	IN
cord-001859-d62iuk72	707	12	100	100	CD
cord-001859-d62iuk72	707	13	μl	μl	NN
cord-001859-d62iuk72	707	14	of	of	IN
cord-001859-d62iuk72	707	15	Nucleofector	Nucleofector	NNP
cord-001859-d62iuk72	707	16	solution	solution	NN
cord-001859-d62iuk72	707	17	V	v	NN
cord-001859-d62iuk72	707	18	(	(	-LRB-
cord-001859-d62iuk72	707	19	Lonza	Lonza	NNP
cord-001859-d62iuk72	707	20	)	)	-RRB-
cord-001859-d62iuk72	707	21	to	to	IN
cord-001859-d62iuk72	707	22	which	which	WDT
cord-001859-d62iuk72	707	23	2	2	CD
cord-001859-d62iuk72	707	24	μM	μM	NNP
cord-001859-d62iuk72	707	25	siRNA	siRNA	NNP
cord-001859-d62iuk72	707	26	(	(	-LRB-
cord-001859-d62iuk72	707	27	scramble	scramble	NN
cord-001859-d62iuk72	707	28	or	or	CC
cord-001859-d62iuk72	707	29	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	707	30	)	)	-RRB-
cord-001859-d62iuk72	707	31	was	be	VBD
cord-001859-d62iuk72	707	32	added	add	VBN
cord-001859-d62iuk72	707	33	.	.	.
cord-001859-d62iuk72	708	1	In	in	IN
cord-001859-d62iuk72	708	2	addition	addition	NN
cord-001859-d62iuk72	708	3	,	,	,
cord-001859-d62iuk72	708	4	to	to	TO
cord-001859-d62iuk72	708	5	monitor	monitor	VB
cord-001859-d62iuk72	708	6	transfection	transfection	NN
cord-001859-d62iuk72	708	7	efficiency	efficiency	NN
cord-001859-d62iuk72	708	8	,	,	,
cord-001859-d62iuk72	708	9	1	1	CD
cord-001859-d62iuk72	708	10	μg	μg	CD
cord-001859-d62iuk72	708	11	of	of	IN
cord-001859-d62iuk72	708	12	the	the	DT
cord-001859-d62iuk72	708	13	control	control	NN
cord-001859-d62iuk72	708	14	plasmid	plasmid	NN
cord-001859-d62iuk72	708	15	pmaxGFP	pmaxGFP	NNP
cord-001859-d62iuk72	708	16	was	be	VBD
cord-001859-d62iuk72	708	17	also	also	RB
cord-001859-d62iuk72	708	18	co	co	VBN
cord-001859-d62iuk72	708	19	-	-	VBN
cord-001859-d62iuk72	708	20	transfected	transfecte	VBN
cord-001859-d62iuk72	708	21	.	.	.
cord-001859-d62iuk72	709	1	Cells	cell	NNS
cord-001859-d62iuk72	709	2	were	be	VBD
cord-001859-d62iuk72	709	3	transfected	transfecte	VBN
cord-001859-d62iuk72	709	4	using	use	VBG
cord-001859-d62iuk72	709	5	program	program	NN
cord-001859-d62iuk72	709	6	T-01	T-01	NNP
cord-001859-d62iuk72	709	7	of	of	IN
cord-001859-d62iuk72	709	8	an	an	DT
cord-001859-d62iuk72	709	9	Amaxa	Amaxa	NNP
cord-001859-d62iuk72	709	10	nucleofector	nucleofector	NN
cord-001859-d62iuk72	709	11	I	-PRON-	PRP
cord-001859-d62iuk72	709	12	(	(	-LRB-
cord-001859-d62iuk72	709	13	Lonza	Lonza	NNP
cord-001859-d62iuk72	709	14	)	)	-RRB-
cord-001859-d62iuk72	709	15	.	.	.
cord-001859-d62iuk72	710	1	After	after	IN
cord-001859-d62iuk72	710	2	nucleofection	nucleofection	NN
cord-001859-d62iuk72	710	3	cells	cell	NNS
cord-001859-d62iuk72	710	4	were	be	VBD
cord-001859-d62iuk72	710	5	maintained	maintain	VBN
cord-001859-d62iuk72	710	6	in	in	IN
cord-001859-d62iuk72	710	7	six	six	CD
cord-001859-d62iuk72	710	8	-	-	HYPH
cord-001859-d62iuk72	710	9	well	well	NN
cord-001859-d62iuk72	710	10	plates	plate	NNS
cord-001859-d62iuk72	710	11	.	.	.
cord-001859-d62iuk72	711	1	Medium	medium	NN
cord-001859-d62iuk72	711	2	was	be	VBD
cord-001859-d62iuk72	711	3	freshly	freshly	RB
cord-001859-d62iuk72	711	4	replaced	replace	VBN
cord-001859-d62iuk72	711	5	every	every	DT
cord-001859-d62iuk72	711	6	day	day	NN
cord-001859-d62iuk72	711	7	.	.	.
cord-001859-d62iuk72	712	1	Confocal	confocal	JJ
cord-001859-d62iuk72	712	2	images	image	NNS
cord-001859-d62iuk72	712	3	were	be	VBD
cord-001859-d62iuk72	712	4	subjected	subject	VBN
cord-001859-d62iuk72	712	5	to	to	IN
cord-001859-d62iuk72	712	6	profiling	profile	VBG
cord-001859-d62iuk72	712	7	analysis	analysis	NN
cord-001859-d62iuk72	712	8	using	use	VBG
cord-001859-d62iuk72	712	9	Zeiss	Zeiss	NNP
cord-001859-d62iuk72	712	10	Zen	Zen	NNP
cord-001859-d62iuk72	712	11	2011	2011	CD
cord-001859-d62iuk72	712	12	software	software	NN
cord-001859-d62iuk72	712	13	.	.	.
cord-001859-d62iuk72	713	1	This	this	DT
cord-001859-d62iuk72	713	2	involved	involved	JJ
cord-001859-d62iuk72	713	3	drawing	draw	VBG
cord-001859-d62iuk72	713	4	a	a	DT
cord-001859-d62iuk72	713	5	line	line	NN
cord-001859-d62iuk72	713	6	in	in	IN
cord-001859-d62iuk72	713	7	a	a	DT
cord-001859-d62iuk72	713	8	confocal	confocal	JJ
cord-001859-d62iuk72	713	9	image	image	NN
cord-001859-d62iuk72	713	10	to	to	TO
cord-001859-d62iuk72	713	11	measure	measure	VB
cord-001859-d62iuk72	713	12	the	the	DT
cord-001859-d62iuk72	713	13	relative	relative	JJ
cord-001859-d62iuk72	713	14	intensity	intensity	NN
cord-001859-d62iuk72	713	15	of	of	IN
cord-001859-d62iuk72	713	16	each	each	DT
cord-001859-d62iuk72	713	17	channel	channel	NN
cord-001859-d62iuk72	713	18	at	at	IN
cord-001859-d62iuk72	713	19	every	every	DT
cord-001859-d62iuk72	713	20	pixel	pixel	NN
cord-001859-d62iuk72	713	21	along	along	IN
cord-001859-d62iuk72	713	22	the	the	DT
cord-001859-d62iuk72	713	23	line	line	NN
cord-001859-d62iuk72	713	24	.	.	.
cord-001859-d62iuk72	714	1	Profiling	profiling	NN
cord-001859-d62iuk72	714	2	was	be	VBD
cord-001859-d62iuk72	714	3	conducted	conduct	VBN
cord-001859-d62iuk72	714	4	for	for	IN
cord-001859-d62iuk72	714	5	each	each	DT
cord-001859-d62iuk72	714	6	cell	cell	NN
cord-001859-d62iuk72	714	7	in	in	IN
cord-001859-d62iuk72	714	8	two	two	CD
cord-001859-d62iuk72	714	9	representative	representative	JJ
cord-001859-d62iuk72	714	10	confocal	confocal	JJ
cord-001859-d62iuk72	714	11	images	image	NNS
cord-001859-d62iuk72	714	12	taken	take	VBN
cord-001859-d62iuk72	714	13	with	with	IN
cord-001859-d62iuk72	714	14	a	a	DT
cord-001859-d62iuk72	714	15	40-times	40-times	CD
cord-001859-d62iuk72	714	16	objective	objective	NN
cord-001859-d62iuk72	714	17	.	.	.
cord-001859-d62iuk72	715	1	These	these	DT
cord-001859-d62iuk72	715	2	data	datum	NNS
cord-001859-d62iuk72	715	3	were	be	VBD
cord-001859-d62iuk72	715	4	then	then	RB
cord-001859-d62iuk72	715	5	analysed	analyse	VBN
cord-001859-d62iuk72	715	6	using	use	VBG
cord-001859-d62iuk72	715	7	Microsoft	Microsoft	NNP
cord-001859-d62iuk72	715	8	Excel	Excel	NNP
cord-001859-d62iuk72	715	9	2010	2010	CD
cord-001859-d62iuk72	715	10	.	.	.
cord-001859-d62iuk72	716	1	Firstly	firstly	RB
cord-001859-d62iuk72	716	2	,	,	,
cord-001859-d62iuk72	716	3	a	a	DT
cord-001859-d62iuk72	716	4	function	function	NN
cord-001859-d62iuk72	716	5	was	be	VBD
cord-001859-d62iuk72	716	6	used	use	VBN
cord-001859-d62iuk72	716	7	to	to	TO
cord-001859-d62iuk72	716	8	define	define	VB
cord-001859-d62iuk72	716	9	whether	whether	IN
cord-001859-d62iuk72	716	10	the	the	DT
cord-001859-d62iuk72	716	11	relative	relative	JJ
cord-001859-d62iuk72	716	12	intensity	intensity	NN
cord-001859-d62iuk72	716	13	of	of	IN
cord-001859-d62iuk72	716	14	a	a	DT
cord-001859-d62iuk72	716	15	pixel	pixel	NN
cord-001859-d62iuk72	716	16	could	could	MD
cord-001859-d62iuk72	716	17	be	be	VB
cord-001859-d62iuk72	716	18	defined	define	VBN
cord-001859-d62iuk72	716	19	as	as	IN
cord-001859-d62iuk72	716	20	a	a	DT
cord-001859-d62iuk72	716	21	"	"	``
cord-001859-d62iuk72	716	22	peak	peak	NN
cord-001859-d62iuk72	716	23	"	"	''
cord-001859-d62iuk72	716	24	and	and	CC
cord-001859-d62iuk72	716	25	thus	thus	RB
cord-001859-d62iuk72	716	26	an	an	DT
cord-001859-d62iuk72	716	27	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	716	28	foci	foci	NN
cord-001859-d62iuk72	716	29	.	.	.
cord-001859-d62iuk72	717	1	This	this	DT
cord-001859-d62iuk72	717	2	function	function	NN
cord-001859-d62iuk72	717	3	asked	ask	VBD
cord-001859-d62iuk72	717	4	whether	whether	IN
cord-001859-d62iuk72	717	5	the	the	DT
cord-001859-d62iuk72	717	6	data	data	NN
cord-001859-d62iuk72	717	7	point	point	NN
cord-001859-d62iuk72	717	8	for	for	IN
cord-001859-d62iuk72	717	9	one	one	CD
cord-001859-d62iuk72	717	10	specific	specific	JJ
cord-001859-d62iuk72	717	11	pixel	pixel	NN
cord-001859-d62iuk72	717	12	of	of	IN
cord-001859-d62iuk72	717	13	the	the	DT
cord-001859-d62iuk72	717	14	rhodamine	rhodamine	JJ
cord-001859-d62iuk72	717	15	channel	channel	NN
cord-001859-d62iuk72	717	16	was	be	VBD
cord-001859-d62iuk72	717	17	20	20	CD
cord-001859-d62iuk72	717	18	,	,	,
cord-001859-d62iuk72	717	19	this	this	DT
cord-001859-d62iuk72	717	20	was	be	VBD
cord-001859-d62iuk72	717	21	set	set	VBN
cord-001859-d62iuk72	717	22	as	as	IN
cord-001859-d62iuk72	717	23	the	the	DT
cord-001859-d62iuk72	717	24	arbitrary	arbitrary	JJ
cord-001859-d62iuk72	717	25	threshold	threshold	NN
cord-001859-d62iuk72	717	26	to	to	TO
cord-001859-d62iuk72	717	27	eliminate	eliminate	VB
cord-001859-d62iuk72	717	28	background	background	NN
cord-001859-d62iuk72	717	29	noise	noise	NN
cord-001859-d62iuk72	717	30	.	.	.
cord-001859-d62iuk72	718	1	If	if	IN
cord-001859-d62iuk72	718	2	this	this	DT
cord-001859-d62iuk72	718	3	condition	condition	NN
cord-001859-d62iuk72	718	4	was	be	VBD
cord-001859-d62iuk72	718	5	met	meet	VBN
cord-001859-d62iuk72	718	6	,	,	,
cord-001859-d62iuk72	718	7	the	the	DT
cord-001859-d62iuk72	718	8	function	function	NN
cord-001859-d62iuk72	718	9	then	then	RB
cord-001859-d62iuk72	718	10	asked	ask	VBD
cord-001859-d62iuk72	718	11	whether	whether	IN
cord-001859-d62iuk72	718	12	the	the	DT
cord-001859-d62iuk72	718	13	data	data	NN
cord-001859-d62iuk72	718	14	point	point	NN
cord-001859-d62iuk72	718	15	was	be	VBD
cord-001859-d62iuk72	718	16	greater	great	JJR
cord-001859-d62iuk72	718	17	than	than	IN
cord-001859-d62iuk72	718	18	or	or	CC
cord-001859-d62iuk72	718	19	equal	equal	JJ
cord-001859-d62iuk72	718	20	to	to	IN
cord-001859-d62iuk72	718	21	the	the	DT
cord-001859-d62iuk72	718	22	data	data	NN
cord-001859-d62iuk72	718	23	point	point	NN
cord-001859-d62iuk72	718	24	in	in	IN
cord-001859-d62iuk72	718	25	the	the	DT
cord-001859-d62iuk72	718	26	previous	previous	JJ
cord-001859-d62iuk72	718	27	and	and	CC
cord-001859-d62iuk72	718	28	subsequent	subsequent	JJ
cord-001859-d62iuk72	718	29	pixel	pixel	NN
cord-001859-d62iuk72	718	30	.	.	.
cord-001859-d62iuk72	719	1	If	if	IN
cord-001859-d62iuk72	719	2	these	these	DT
cord-001859-d62iuk72	719	3	conditions	condition	NNS
cord-001859-d62iuk72	719	4	were	be	VBD
cord-001859-d62iuk72	719	5	true	true	JJ
cord-001859-d62iuk72	719	6	,	,	,
cord-001859-d62iuk72	719	7	then	then	RB
cord-001859-d62iuk72	719	8	this	this	DT
cord-001859-d62iuk72	719	9	data	datum	NNS
cord-001859-d62iuk72	719	10	point	point	NN
cord-001859-d62iuk72	719	11	was	be	VBD
cord-001859-d62iuk72	719	12	counted	count	VBN
cord-001859-d62iuk72	719	13	as	as	IN
cord-001859-d62iuk72	719	14	a	a	DT
cord-001859-d62iuk72	719	15	peak	peak	NN
cord-001859-d62iuk72	719	16	.	.	.
cord-001859-d62iuk72	720	1	This	this	DT
cord-001859-d62iuk72	720	2	was	be	VBD
cord-001859-d62iuk72	720	3	performed	perform	VBN
cord-001859-d62iuk72	720	4	for	for	IN
cord-001859-d62iuk72	720	5	every	every	DT
cord-001859-d62iuk72	720	6	data	data	NN
cord-001859-d62iuk72	720	7	point	point	NN
cord-001859-d62iuk72	720	8	measured	measure	VBN
cord-001859-d62iuk72	720	9	in	in	IN
cord-001859-d62iuk72	720	10	the	the	DT
cord-001859-d62iuk72	720	11	line	line	NN
cord-001859-d62iuk72	720	12	profile	profile	NN
cord-001859-d62iuk72	720	13	providing	provide	VBG
cord-001859-d62iuk72	720	14	the	the	DT
cord-001859-d62iuk72	720	15	total	total	JJ
cord-001859-d62iuk72	720	16	number	number	NN
cord-001859-d62iuk72	720	17	of	of	IN
cord-001859-d62iuk72	720	18	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	720	19	peaks	peak	NNS
cord-001859-d62iuk72	720	20	in	in	IN
cord-001859-d62iuk72	720	21	the	the	DT
cord-001859-d62iuk72	720	22	profile	profile	NN
cord-001859-d62iuk72	720	23	of	of	IN
cord-001859-d62iuk72	720	24	one	one	CD
cord-001859-d62iuk72	720	25	cell	cell	NN
cord-001859-d62iuk72	720	26	.	.	.
cord-001859-d62iuk72	721	1	Next	next	RB
cord-001859-d62iuk72	721	2	,	,	,
cord-001859-d62iuk72	721	3	another	another	DT
cord-001859-d62iuk72	721	4	function	function	NN
cord-001859-d62iuk72	721	5	was	be	VBD
cord-001859-d62iuk72	721	6	used	use	VBN
cord-001859-d62iuk72	721	7	to	to	TO
cord-001859-d62iuk72	721	8	determine	determine	VB
cord-001859-d62iuk72	721	9	whether	whether	IN
cord-001859-d62iuk72	721	10	the	the	DT
cord-001859-d62iuk72	721	11	relative	relative	JJ
cord-001859-d62iuk72	721	12	intensity	intensity	NN
cord-001859-d62iuk72	721	13	in	in	IN
cord-001859-d62iuk72	721	14	the	the	DT
cord-001859-d62iuk72	721	15	DAPI	DAPI	NNP
cord-001859-d62iuk72	721	16	channel	channel	NN
cord-001859-d62iuk72	721	17	was	be	VBD
cord-001859-d62iuk72	721	18	25	25	CD
cord-001859-d62iuk72	721	19	,	,	,
cord-001859-d62iuk72	721	20	a	a	DT
cord-001859-d62iuk72	721	21	threshold	threshold	NN
cord-001859-d62iuk72	721	22	determined	determine	VBN
cord-001859-d62iuk72	721	23	from	from	IN
cord-001859-d62iuk72	721	24	visualising	visualise	VBG
cord-001859-d62iuk72	721	25	the	the	DT
cord-001859-d62iuk72	721	26	line	line	NN
cord-001859-d62iuk72	721	27	profiling	profile	VBG
cord-001859-d62iuk72	721	28	data	datum	NNS
cord-001859-d62iuk72	721	29	as	as	IN
cord-001859-d62iuk72	721	30	a	a	DT
cord-001859-d62iuk72	721	31	graph	graph	NN
cord-001859-d62iuk72	721	32	.	.	.
cord-001859-d62iuk72	722	1	If	if	IN
cord-001859-d62iuk72	722	2	a	a	DT
cord-001859-d62iuk72	722	3	pixel	pixel	NN
cord-001859-d62iuk72	722	4	was	be	VBD
cord-001859-d62iuk72	722	5	shown	show	VBN
cord-001859-d62iuk72	722	6	to	to	TO
cord-001859-d62iuk72	722	7	exceed	exceed	VB
cord-001859-d62iuk72	722	8	the	the	DT
cord-001859-d62iuk72	722	9	threshold	threshold	NN
cord-001859-d62iuk72	722	10	in	in	IN
cord-001859-d62iuk72	722	11	the	the	DT
cord-001859-d62iuk72	722	12	DAPI	DAPI	NNP
cord-001859-d62iuk72	722	13	channel	channel	NN
cord-001859-d62iuk72	722	14	and	and	CC
cord-001859-d62iuk72	722	15	also	also	RB
cord-001859-d62iuk72	722	16	in	in	IN
cord-001859-d62iuk72	722	17	the	the	DT
cord-001859-d62iuk72	722	18	rhodamine	rhodamine	NN
cord-001859-d62iuk72	722	19	channel	channel	NN
cord-001859-d62iuk72	722	20	,	,	,
cord-001859-d62iuk72	722	21	then	then	RB
cord-001859-d62iuk72	722	22	it	-PRON-	PRP
cord-001859-d62iuk72	722	23	was	be	VBD
cord-001859-d62iuk72	722	24	counted	count	VBN
cord-001859-d62iuk72	722	25	as	as	IN
cord-001859-d62iuk72	722	26	a	a	DT
cord-001859-d62iuk72	722	27	nuclear	nuclear	JJ
cord-001859-d62iuk72	722	28	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	722	29	peak	peak	NN
cord-001859-d62iuk72	722	30	.	.	.
cord-001859-d62iuk72	723	1	These	these	DT
cord-001859-d62iuk72	723	2	measurements	measurement	NNS
cord-001859-d62iuk72	723	3	were	be	VBD
cord-001859-d62iuk72	723	4	conducted	conduct	VBN
cord-001859-d62iuk72	723	5	for	for	IN
cord-001859-d62iuk72	723	6	each	each	DT
cord-001859-d62iuk72	723	7	pixel	pixel	NN
cord-001859-d62iuk72	723	8	in	in	IN
cord-001859-d62iuk72	723	9	each	each	DT
cord-001859-d62iuk72	723	10	profile	profile	NN
cord-001859-d62iuk72	723	11	allowing	allow	VBG
cord-001859-d62iuk72	723	12	counting	count	VBG
cord-001859-d62iuk72	723	13	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	723	14	nuclear	nuclear	JJ
cord-001859-d62iuk72	723	15	peaks	peak	NNS
cord-001859-d62iuk72	723	16	in	in	IN
cord-001859-d62iuk72	723	17	each	each	DT
cord-001859-d62iuk72	723	18	profile	profile	NN
cord-001859-d62iuk72	723	19	.	.	.
cord-001859-d62iuk72	724	1	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	725	1	peaks	peak	NNS
cord-001859-d62iuk72	725	2	outside	outside	IN
cord-001859-d62iuk72	725	3	the	the	DT
cord-001859-d62iuk72	725	4	nucleus	nucleus	NN
cord-001859-d62iuk72	725	5	corresponded	correspond	VBD
cord-001859-d62iuk72	725	6	to	to	IN
cord-001859-d62iuk72	725	7	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	725	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	725	9	peaks	peak	NNS
cord-001859-d62iuk72	725	10	.	.	.
cord-001859-d62iuk72	726	1	Oligonucleotide	oligonucleotide	JJ
cord-001859-d62iuk72	726	2	primer	primer	NN
cord-001859-d62iuk72	726	3	sequences	sequence	NNS
cord-001859-d62iuk72	726	4	are	be	VBP
cord-001859-d62iuk72	726	5	available	available	JJ
cord-001859-d62iuk72	726	6	upon	upon	IN
cord-001859-d62iuk72	726	7	request	request	NN
cord-001859-d62iuk72	726	8	.	.	.
cord-001859-d62iuk72	727	1	All	all	DT
cord-001859-d62iuk72	727	2	primers	primer	NNS
cord-001859-d62iuk72	727	3	were	be	VBD
cord-001859-d62iuk72	727	4	purchased	purchase	VBN
cord-001859-d62iuk72	727	5	from	from	IN
cord-001859-d62iuk72	727	6	Sigma	Sigma	NNP
cord-001859-d62iuk72	727	7	(	(	-LRB-
cord-001859-d62iuk72	727	8	UK	UK	NNP
cord-001859-d62iuk72	727	9	)	)	-RRB-
cord-001859-d62iuk72	727	10	.	.	.
cord-001859-d62iuk72	728	1	Supporting	support	VBG
cord-001859-d62iuk72	728	2	Information	information	NN
cord-001859-d62iuk72	728	3	S1	S1	NNP
cord-001859-d62iuk72	728	4	Table	Table	NNP
cord-001859-d62iuk72	728	5	.	.	.
cord-001859-d62iuk72	729	1	Cellular	cellular	JJ
cord-001859-d62iuk72	729	2	proteins	protein	NNS
cord-001859-d62iuk72	729	3	previously	previously	RB
cord-001859-d62iuk72	729	4	reported	report	VBD
cord-001859-d62iuk72	729	5	to	to	TO
cord-001859-d62iuk72	729	6	localise	localise	VB
cord-001859-d62iuk72	729	7	to	to	IN
cord-001859-d62iuk72	729	8	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	729	9	RTCs	rtc	NNS
cord-001859-d62iuk72	729	10	and	and	CC
cord-001859-d62iuk72	729	11	found	find	VBD
cord-001859-d62iuk72	729	12	significantly	significantly	RB
cord-001859-d62iuk72	729	13	increased	increase	VBN
cord-001859-d62iuk72	729	14	in	in	IN
cord-001859-d62iuk72	729	15	the	the	DT
cord-001859-d62iuk72	729	16	NE	NE	NNP
cord-001859-d62iuk72	729	17	of	of	IN
cord-001859-d62iuk72	729	18	reactivated	reactivate	VBN
cord-001859-d62iuk72	729	19	cells	cell	NNS
cord-001859-d62iuk72	729	20	.	.	.
cord-001859-d62iuk72	730	1	(	(	-LRB-
cord-001859-d62iuk72	730	2	XLS	XLS	NNP
cord-001859-d62iuk72	730	3	)	)	-RRB-
cord-001859-d62iuk72	730	4	S1	S1	NNP
cord-001859-d62iuk72	730	5	Fig	Fig	NNP
cord-001859-d62iuk72	730	6	.	.	.
cord-001859-d62iuk72	731	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	731	2	was	be	VBD
cord-001859-d62iuk72	731	3	redistributed	redistribute	VBN
cord-001859-d62iuk72	731	4	from	from	IN
cord-001859-d62iuk72	731	5	the	the	DT
cord-001859-d62iuk72	731	6	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	731	7	to	to	IN
cord-001859-d62iuk72	731	8	both	both	CC
cord-001859-d62iuk72	731	9	the	the	DT
cord-001859-d62iuk72	731	10	periphery	periphery	NN
cord-001859-d62iuk72	731	11	and	and	CC
cord-001859-d62iuk72	731	12	within	within	IN
cord-001859-d62iuk72	731	13	KSHV	KSHV	NNP
cord-001859-d62iuk72	731	14	-	-	HYPH
cord-001859-d62iuk72	731	15	induced	induce	VBN
cord-001859-d62iuk72	731	16	RTCs	rtcs	NN
cord-001859-d62iuk72	731	17	.	.	.
cord-001859-d62iuk72	732	1	(	(	-LRB-
cord-001859-d62iuk72	732	2	A	a	NN
cord-001859-d62iuk72	732	3	)	)	-RRB-
cord-001859-d62iuk72	732	4	TREx	TREx	NNS
cord-001859-d62iuk72	732	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	732	6	cells	cell	NNS
cord-001859-d62iuk72	732	7	remained	remain	VBD
cord-001859-d62iuk72	732	8	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	732	9	or	or	CC
cord-001859-d62iuk72	732	10	reactivated	reactivate	VBN
cord-001859-d62iuk72	732	11	for	for	IN
cord-001859-d62iuk72	732	12	either	either	CC
cord-001859-d62iuk72	732	13	20	20	CD
cord-001859-d62iuk72	732	14	h	h	NN
cord-001859-d62iuk72	732	15	or	or	CC
cord-001859-d62iuk72	732	16	24	24	CD
cord-001859-d62iuk72	732	17	h.	h.	NN
cord-001859-d62iuk72	733	1	In	in	IN
cord-001859-d62iuk72	733	2	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	733	3	cells	cell	NNS
cord-001859-d62iuk72	734	1	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	734	2	was	be	VBD
cord-001859-d62iuk72	734	3	cytoplasmic	cytoplasmic	JJ
cord-001859-d62iuk72	734	4	(	(	-LRB-
cord-001859-d62iuk72	734	5	i	i	NN
cord-001859-d62iuk72	734	6	)	)	-RRB-
cord-001859-d62iuk72	734	7	.	.	.
cord-001859-d62iuk72	735	1	In	in	IN
cord-001859-d62iuk72	735	2	contrast	contrast	NN
cord-001859-d62iuk72	735	3	,	,	,
cord-001859-d62iuk72	735	4	at	at	IN
cord-001859-d62iuk72	735	5	20	20	CD
cord-001859-d62iuk72	735	6	h	h	NN
cord-001859-d62iuk72	735	7	reactivation	reactivation	NN
cord-001859-d62iuk72	735	8	an	an	DT
cord-001859-d62iuk72	735	9	increase	increase	NN
cord-001859-d62iuk72	735	10	in	in	IN
cord-001859-d62iuk72	735	11	nuclear	nuclear	JJ
cord-001859-d62iuk72	735	12	iHsp70	iHsp70	.
cord-001859-d62iuk72	735	13	labelling	labelling	NN
cord-001859-d62iuk72	735	14	was	be	VBD
cord-001859-d62iuk72	735	15	seen	see	VBN
cord-001859-d62iuk72	735	16	with	with	IN
cord-001859-d62iuk72	735	17	numerous	numerous	JJ
cord-001859-d62iuk72	735	18	small	small	JJ
cord-001859-d62iuk72	735	19	iHsp70	iHsp70	.
cord-001859-d62iuk72	735	20	foci	foci	NN
cord-001859-d62iuk72	735	21	found	find	VBN
cord-001859-d62iuk72	735	22	mainly	mainly	RB
cord-001859-d62iuk72	735	23	adjacent	adjacent	JJ
cord-001859-d62iuk72	735	24	to	to	IN
cord-001859-d62iuk72	735	25	viral	viral	JJ
cord-001859-d62iuk72	735	26	RTCs	rtc	NNS
cord-001859-d62iuk72	735	27	(	(	-LRB-
cord-001859-d62iuk72	735	28	ii	ii	NN
cord-001859-d62iuk72	735	29	)	)	-RRB-
cord-001859-d62iuk72	735	30	.	.	.
cord-001859-d62iuk72	736	1	Some	some	DT
cord-001859-d62iuk72	736	2	cells	cell	NNS
cord-001859-d62iuk72	736	3	displayed	display	VBD
cord-001859-d62iuk72	736	4	iHsp70	ihsp70	IN
cord-001859-d62iuk72	736	5	completely	completely	RB
cord-001859-d62iuk72	736	6	recruited	recruit	VBN
cord-001859-d62iuk72	736	7	within	within	IN
cord-001859-d62iuk72	736	8	RTCs	RTCs	NNP
cord-001859-d62iuk72	736	9	(	(	-LRB-
cord-001859-d62iuk72	736	10	iii	iii	NNP
cord-001859-d62iuk72	736	11	and	and	CC
cord-001859-d62iuk72	736	12	iv	iv	NNP
cord-001859-d62iuk72	736	13	asterisks	asterisks	NNP
cord-001859-d62iuk72	736	14	)	)	-RRB-
cord-001859-d62iuk72	736	15	,	,	,
cord-001859-d62iuk72	736	16	while	while	IN
cord-001859-d62iuk72	736	17	other	other	JJ
cord-001859-d62iuk72	736	18	cells	cell	NNS
cord-001859-d62iuk72	736	19	accumulated	accumulate	VBD
cord-001859-d62iuk72	736	20	large	large	JJ
cord-001859-d62iuk72	736	21	iHsp70	ihsp70	XX
cord-001859-d62iuk72	736	22	adjacent	adjacent	JJ
cord-001859-d62iuk72	736	23	to	to	IN
cord-001859-d62iuk72	736	24	RTCs	RTCs	NNP
cord-001859-d62iuk72	736	25	(	(	-LRB-
cord-001859-d62iuk72	736	26	iv	iv	IN
cord-001859-d62iuk72	736	27	arrows	arrow	NNS
cord-001859-d62iuk72	736	28	)	)	-RRB-
cord-001859-d62iuk72	736	29	.	.	.
cord-001859-d62iuk72	737	1	(	(	-LRB-
cord-001859-d62iuk72	737	2	B	b	NN
cord-001859-d62iuk72	737	3	)	)	-RRB-
cord-001859-d62iuk72	737	4	TREx	TREx	NNS
cord-001859-d62iuk72	737	5	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	737	6	cells	cell	NNS
cord-001859-d62iuk72	737	7	remained	remain	VBD
cord-001859-d62iuk72	737	8	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	737	9	(	(	-LRB-
cord-001859-d62iuk72	737	10	i	i	NN
cord-001859-d62iuk72	737	11	)	)	-RRB-
cord-001859-d62iuk72	737	12	or	or	CC
cord-001859-d62iuk72	737	13	reactivated	reactivate	VBN
cord-001859-d62iuk72	737	14	for	for	IN
cord-001859-d62iuk72	737	15	24	24	CD
cord-001859-d62iuk72	737	16	h	h	NNP
cord-001859-d62iuk72	737	17	(	(	-LRB-
cord-001859-d62iuk72	737	18	ii	ii	NNP
cord-001859-d62iuk72	737	19	and	and	CC
cord-001859-d62iuk72	737	20	iii	iii	NNP
cord-001859-d62iuk72	737	21	)	)	-RRB-
cord-001859-d62iuk72	737	22	followed	follow	VBN
cord-001859-d62iuk72	737	23	by	by	IN
cord-001859-d62iuk72	737	24	triple	triple	JJ
cord-001859-d62iuk72	737	25	-	-	HYPH
cord-001859-d62iuk72	737	26	labelling	labelling	NN
cord-001859-d62iuk72	737	27	with	with	IN
cord-001859-d62iuk72	737	28	antibodies	antibody	NNS
cord-001859-d62iuk72	737	29	specific	specific	JJ
cord-001859-d62iuk72	737	30	for	for	IN
cord-001859-d62iuk72	737	31	RTA	RTA	NNP
cord-001859-d62iuk72	737	32	and	and	CC
cord-001859-d62iuk72	737	33	iHsp70	ihsp70	NN
cord-001859-d62iuk72	737	34	and	and	CC
cord-001859-d62iuk72	737	35	Click	click	VB
cord-001859-d62iuk72	738	1	-iT	-iT	:
cord-001859-d62iuk72	739	1	EdU	EdU	NNP
cord-001859-d62iuk72	739	2	Alexa	Alexa	NNP
cord-001859-d62iuk72	739	3	Fluor	Fluor	NNP
cord-001859-d62iuk72	739	4	647	647	CD
cord-001859-d62iuk72	739	5	.	.	.
cord-001859-d62iuk72	740	1	Complete	complete	JJ
cord-001859-d62iuk72	740	2	co	co	NN
cord-001859-d62iuk72	740	3	-	-	NN
cord-001859-d62iuk72	740	4	localisation	localisation	NN
cord-001859-d62iuk72	741	1	between	between	IN
cord-001859-d62iuk72	741	2	iHsp70	iHsp70	NNP
cord-001859-d62iuk72	741	3	,	,	,
cord-001859-d62iuk72	741	4	RTA	RTA	NNP
cord-001859-d62iuk72	741	5	and	and	CC
cord-001859-d62iuk72	741	6	actively	actively	RB
cord-001859-d62iuk72	741	7	replicated	replicate	VBD
cord-001859-d62iuk72	741	8	viral	viral	JJ
cord-001859-d62iuk72	741	9	DNA	dna	NN
cord-001859-d62iuk72	741	10	(	(	-LRB-
cord-001859-d62iuk72	741	11	Edu	Edu	NNP
cord-001859-d62iuk72	741	12	-	-	HYPH
cord-001859-d62iuk72	741	13	labelled	label	VBN
cord-001859-d62iuk72	741	14	)	)	-RRB-
cord-001859-d62iuk72	741	15	was	be	VBD
cord-001859-d62iuk72	741	16	observed	observe	VBN
cord-001859-d62iuk72	741	17	in	in	IN
cord-001859-d62iuk72	741	18	both	both	DT
cord-001859-d62iuk72	741	19	incipient	incipient	JJ
cord-001859-d62iuk72	741	20	RTCs	rtc	NNS
cord-001859-d62iuk72	741	21	(	(	-LRB-
cord-001859-d62iuk72	741	22	ii	ii	NN
cord-001859-d62iuk72	741	23	)	)	-RRB-
cord-001859-d62iuk72	741	24	and	and	CC
cord-001859-d62iuk72	741	25	in	in	IN
cord-001859-d62iuk72	741	26	fully	fully	RB
cord-001859-d62iuk72	741	27	-	-	HYPH
cord-001859-d62iuk72	741	28	developed	develop	VBN
cord-001859-d62iuk72	741	29	RTCs	rtc	NNS
cord-001859-d62iuk72	741	30	(	(	-LRB-
cord-001859-d62iuk72	741	31	iii	iii	NN
cord-001859-d62iuk72	741	32	)	)	-RRB-
cord-001859-d62iuk72	741	33	.	.	.
cord-001859-d62iuk72	742	1	Note	note	VB
cord-001859-d62iuk72	742	2	that	that	IN
cord-001859-d62iuk72	742	3	in	in	IN
cord-001859-d62iuk72	742	4	these	these	DT
cord-001859-d62iuk72	742	5	cells	cell	NNS
cord-001859-d62iuk72	742	6	iHsp70	iHsp70	''
cord-001859-d62iuk72	742	7	was	be	VBD
cord-001859-d62iuk72	742	8	not	not	RB
cord-001859-d62iuk72	742	9	depleted	deplete	VBN
cord-001859-d62iuk72	742	10	from	from	IN
cord-001859-d62iuk72	742	11	the	the	DT
cord-001859-d62iuk72	742	12	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	742	13	.	.	.
cord-001859-d62iuk72	743	1	TREx	TREx	NNP
cord-001859-d62iuk72	743	2	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	743	3	cells	cell	NNS
cord-001859-d62iuk72	743	4	remained	remain	VBD
cord-001859-d62iuk72	743	5	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	743	6	or	or	CC
cord-001859-d62iuk72	743	7	reactivated	reactivate	VBN
cord-001859-d62iuk72	743	8	for	for	IN
cord-001859-d62iuk72	743	9	24	24	CD
cord-001859-d62iuk72	743	10	h	h	NN
cord-001859-d62iuk72	743	11	in	in	IN
cord-001859-d62iuk72	743	12	the	the	DT
cord-001859-d62iuk72	743	13	presence	presence	NN
cord-001859-d62iuk72	743	14	of	of	IN
cord-001859-d62iuk72	743	15	control	control	NN
cord-001859-d62iuk72	743	16	DMSO	DMSO	NNP
cord-001859-d62iuk72	743	17	(	(	-LRB-
cord-001859-d62iuk72	743	18	0.1	0.1	CD
cord-001859-d62iuk72	743	19	%	%	NN
cord-001859-d62iuk72	743	20	)	)	-RRB-
cord-001859-d62iuk72	743	21	or	or	CC
cord-001859-d62iuk72	744	1	2	2	LS
cord-001859-d62iuk72	744	2	μM	μm	CD
cord-001859-d62iuk72	744	3	VER-155008	ver-155008	NN
cord-001859-d62iuk72	744	4	followed	follow	VBN
cord-001859-d62iuk72	744	5	by	by	IN
cord-001859-d62iuk72	744	6	labelling	label	VBG
cord-001859-d62iuk72	744	7	with	with	IN
cord-001859-d62iuk72	744	8	Click	click	NN
cord-001859-d62iuk72	744	9	-	-	:
cord-001859-d62iuk72	744	10	iT	it	PRP
cord-001859-d62iuk72	745	1	EdU	EdU	NNP
cord-001859-d62iuk72	745	2	Alexa	Alexa	NNP
cord-001859-d62iuk72	745	3	Fluor	Fluor	NNP
cord-001859-d62iuk72	745	4	647	647	CD
cord-001859-d62iuk72	745	5	and	and	CC
cord-001859-d62iuk72	745	6	an	an	DT
cord-001859-d62iuk72	745	7	antibody	antibody	NN
cord-001859-d62iuk72	745	8	specific	specific	JJ
cord-001859-d62iuk72	745	9	for	for	IN
cord-001859-d62iuk72	745	10	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	745	11	(	(	-LRB-
cord-001859-d62iuk72	745	12	clone	clone	NN
cord-001859-d62iuk72	745	13	CTD4H8	CTD4H8	NNP
cord-001859-d62iuk72	745	14	)	)	-RRB-
cord-001859-d62iuk72	745	15	.	.	.
cord-001859-d62iuk72	746	1	(	(	-LRB-
cord-001859-d62iuk72	746	2	A	a	NN
cord-001859-d62iuk72	746	3	)	)	-RRB-
cord-001859-d62iuk72	746	4	A	a	DT
cord-001859-d62iuk72	746	5	high	high	JJ
cord-001859-d62iuk72	746	6	proportion	proportion	NN
cord-001859-d62iuk72	746	7	of	of	IN
cord-001859-d62iuk72	746	8	unreactivated	unreactivated	JJ
cord-001859-d62iuk72	746	9	TREx	TREx	NNS
cord-001859-d62iuk72	746	10	BCBL1-RTA	BCBL1-RTA	NNP
cord-001859-d62iuk72	746	11	cells	cell	NNS
cord-001859-d62iuk72	746	12	replicated	replicate	VBD
cord-001859-d62iuk72	746	13	their	-PRON-	PRP$
cord-001859-d62iuk72	746	14	cellular	cellular	JJ
cord-001859-d62iuk72	746	15	DNA	dna	NN
cord-001859-d62iuk72	746	16	(	(	-LRB-
cord-001859-d62iuk72	746	17	Edu	Edu	NNP
cord-001859-d62iuk72	746	18	-	-	HYPH
cord-001859-d62iuk72	746	19	labelled	label	VBN
cord-001859-d62iuk72	746	20	)	)	-RRB-
cord-001859-d62iuk72	746	21	in	in	IN
cord-001859-d62iuk72	746	22	the	the	DT
cord-001859-d62iuk72	746	23	presence	presence	NN
cord-001859-d62iuk72	746	24	of	of	IN
cord-001859-d62iuk72	746	25	control	control	NN
cord-001859-d62iuk72	746	26	DMSO	DMSO	NNP
cord-001859-d62iuk72	746	27	(	(	-LRB-
cord-001859-d62iuk72	746	28	0.1	0.1	CD
cord-001859-d62iuk72	746	29	%	%	NN
cord-001859-d62iuk72	746	30	)	)	-RRB-
cord-001859-d62iuk72	746	31	or	or	CC
cord-001859-d62iuk72	746	32	2	2	CD
cord-001859-d62iuk72	746	33	μM	μm	CD
cord-001859-d62iuk72	746	34	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	746	35	.	.	.
cord-001859-d62iuk72	747	1	Normal	normal	JJ
cord-001859-d62iuk72	747	2	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	747	3	localization	localization	NN
cord-001859-d62iuk72	747	4	was	be	VBD
cord-001859-d62iuk72	747	5	observed	observe	VBN
cord-001859-d62iuk72	747	6	in	in	IN
cord-001859-d62iuk72	747	7	these	these	DT
cord-001859-d62iuk72	747	8	cells	cell	NNS
cord-001859-d62iuk72	747	9	,	,	,
cord-001859-d62iuk72	747	10	with	with	IN
cord-001859-d62iuk72	747	11	nuclear	nuclear	JJ
cord-001859-d62iuk72	747	12	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	747	13	excluding	exclude	VBG
cord-001859-d62iuk72	747	14	the	the	DT
cord-001859-d62iuk72	747	15	nucleoli	nucleoli	NNP
cord-001859-d62iuk72	747	16	.	.	.
cord-001859-d62iuk72	748	1	(	(	-LRB-
cord-001859-d62iuk72	748	2	B	b	NN
cord-001859-d62iuk72	748	3	)	)	-RRB-
cord-001859-d62iuk72	749	1	In	in	IN
cord-001859-d62iuk72	749	2	contrast	contrast	NN
cord-001859-d62iuk72	749	3	,	,	,
cord-001859-d62iuk72	749	4	reactivated	reactivate	VBN
cord-001859-d62iuk72	749	5	cells	cell	NNS
cord-001859-d62iuk72	749	6	entered	enter	VBD
cord-001859-d62iuk72	749	7	cell	cell	NN
cord-001859-d62iuk72	749	8	cycle	cycle	NN
cord-001859-d62iuk72	749	9	arrest	arrest	NN
cord-001859-d62iuk72	749	10	as	as	IN
cord-001859-d62iuk72	749	11	demonstrated	demonstrate	VBN
cord-001859-d62iuk72	749	12	by	by	IN
cord-001859-d62iuk72	749	13	fewer	few	JJR
cord-001859-d62iuk72	749	14	Edu	Edu	NNP
cord-001859-d62iuk72	749	15	-	-	HYPH
cord-001859-d62iuk72	749	16	labelled	label	VBN
cord-001859-d62iuk72	749	17	cells	cell	NNS
cord-001859-d62iuk72	749	18	.	.	.
cord-001859-d62iuk72	750	1	In	in	IN
cord-001859-d62iuk72	750	2	the	the	DT
cord-001859-d62iuk72	750	3	presence	presence	NN
cord-001859-d62iuk72	750	4	of	of	IN
cord-001859-d62iuk72	750	5	DMSO	DMSO	NNP
cord-001859-d62iuk72	750	6	,	,	,
cord-001859-d62iuk72	750	7	multiple	multiple	JJ
cord-001859-d62iuk72	750	8	RTCs	rtc	NNS
cord-001859-d62iuk72	750	9	were	be	VBD
cord-001859-d62iuk72	750	10	formed	form	VBN
cord-001859-d62iuk72	750	11	with	with	IN
cord-001859-d62iuk72	750	12	some	some	DT
cord-001859-d62iuk72	750	13	replicating	replicate	VBG
cord-001859-d62iuk72	750	14	viral	viral	JJ
cord-001859-d62iuk72	750	15	DNA	dna	NN
cord-001859-d62iuk72	750	16	(	(	-LRB-
cord-001859-d62iuk72	750	17	white	white	JJ
cord-001859-d62iuk72	750	18	arrows	arrow	NNS
cord-001859-d62iuk72	750	19	)	)	-RRB-
cord-001859-d62iuk72	750	20	.	.	.
cord-001859-d62iuk72	751	1	In	in	IN
cord-001859-d62iuk72	751	2	cells	cell	NNS
cord-001859-d62iuk72	751	3	treated	treat	VBN
cord-001859-d62iuk72	751	4	with	with	IN
cord-001859-d62iuk72	751	5	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	751	6	,	,	,
cord-001859-d62iuk72	751	7	multiple	multiple	JJ
cord-001859-d62iuk72	751	8	pre	pre	JJ
cord-001859-d62iuk72	751	9	-	-	JJ
cord-001859-d62iuk72	751	10	replicative	replicative	JJ
cord-001859-d62iuk72	751	11	sites	site	NNS
cord-001859-d62iuk72	751	12	were	be	VBD
cord-001859-d62iuk72	751	13	seen	see	VBN
cord-001859-d62iuk72	751	14	labelled	label	VBN
cord-001859-d62iuk72	751	15	by	by	IN
cord-001859-d62iuk72	751	16	RNAPII	RNAPII	NNP
cord-001859-d62iuk72	751	17	antibody	antibody	NN
cord-001859-d62iuk72	751	18	and	and	CC
cord-001859-d62iuk72	751	19	Edu	Edu	NNP
cord-001859-d62iuk72	751	20	-	-	HYPH
cord-001859-d62iuk72	751	21	labelling	labelling	NN
cord-001859-d62iuk72	751	22	was	be	VBD
cord-001859-d62iuk72	751	23	more	more	RBR
cord-001859-d62iuk72	751	24	diffused	diffuse	VBN
cord-001859-d62iuk72	751	25	in	in	IN
cord-001859-d62iuk72	751	26	the	the	DT
cord-001859-d62iuk72	751	27	nucleus	nucleus	NN
cord-001859-d62iuk72	751	28	compared	compare	VBN
cord-001859-d62iuk72	751	29	with	with	IN
cord-001859-d62iuk72	751	30	DMSO	DMSO	NNP
cord-001859-d62iuk72	751	31	-	-	HYPH
cord-001859-d62iuk72	751	32	treated	treat	VBN
cord-001859-d62iuk72	751	33	cells	cell	NNS
cord-001859-d62iuk72	751	34	.	.	.
cord-001859-d62iuk72	752	1	(	(	-LRB-
cord-001859-d62iuk72	752	2	TIF	tif	NN
cord-001859-d62iuk72	752	3	)	)	-RRB-
cord-001859-d62iuk72	753	1	Chaperone	chaperone	NN
cord-001859-d62iuk72	753	2	machines	machine	NNS
cord-001859-d62iuk72	753	3	for	for	IN
cord-001859-d62iuk72	753	4	protein	protein	NN
cord-001859-d62iuk72	753	5	folding	folding	NN
cord-001859-d62iuk72	753	6	,	,	,
cord-001859-d62iuk72	753	7	unfolding	unfold	VBG
cord-001859-d62iuk72	753	8	and	and	CC
cord-001859-d62iuk72	753	9	disaggregation	disaggregation	NN
cord-001859-d62iuk72	753	10	Folding	folding	NN
cord-001859-d62iuk72	753	11	of	of	IN
cord-001859-d62iuk72	753	12	newly	newly	RB
cord-001859-d62iuk72	753	13	translated	translate	VBN
cord-001859-d62iuk72	753	14	proteins	protein	NNS
cord-001859-d62iuk72	753	15	in	in	IN
cord-001859-d62iuk72	753	16	vivo	vivo	NN
cord-001859-d62iuk72	753	17	:	:	:
cord-001859-d62iuk72	754	1	The	the	DT
cord-001859-d62iuk72	754	2	role	role	NN
cord-001859-d62iuk72	754	3	of	of	IN
cord-001859-d62iuk72	754	4	molecular	molecular	JJ
cord-001859-d62iuk72	754	5	chaperones	chaperone	NNS
cord-001859-d62iuk72	754	6	Chaperones	Chaperones	NNPS
cord-001859-d62iuk72	754	7	:	:	:
cord-001859-d62iuk72	754	8	General	General	NNP
cord-001859-d62iuk72	754	9	Characteristics	Characteristics	NNPS
cord-001859-d62iuk72	754	10	and	and	CC
cord-001859-d62iuk72	754	11	Classifications	Classifications	NNPS
cord-001859-d62iuk72	754	12	.	.	.
cord-001859-d62iuk72	755	1	The	the	DT
cord-001859-d62iuk72	755	2	Chaperonopathies	Chaperonopathies	NNPS
cord-001859-d62iuk72	755	3	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	755	4	in	in	IN
cord-001859-d62iuk72	755	5	cancer	cancer	NN
cord-001859-d62iuk72	755	6	:	:	:
cord-001859-d62iuk72	755	7	back	back	RB
cord-001859-d62iuk72	755	8	to	to	IN
cord-001859-d62iuk72	755	9	the	the	DT
cord-001859-d62iuk72	755	10	future	future	NN
cord-001859-d62iuk72	755	11	HSP90	HSP90	NNP
cord-001859-d62iuk72	755	12	and	and	CC
cord-001859-d62iuk72	755	13	the	the	DT
cord-001859-d62iuk72	755	14	chaperoning	chaperoning	NN
cord-001859-d62iuk72	755	15	of	of	IN
cord-001859-d62iuk72	755	16	cancer	cancer	NN
cord-001859-d62iuk72	755	17	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	755	18	Molecular	Molecular	NNP
cord-001859-d62iuk72	755	19	Chaperones	Chaperones	NNPS
cord-001859-d62iuk72	755	20	and	and	CC
cord-001859-d62iuk72	755	21	Parkinson	Parkinson	NNP
cord-001859-d62iuk72	755	22	's	's	POS
cord-001859-d62iuk72	755	23	Disease	Disease	NNP
cord-001859-d62iuk72	755	24	Broad	Broad	NNP
cord-001859-d62iuk72	755	25	action	action	NN
cord-001859-d62iuk72	755	26	of	of	IN
cord-001859-d62iuk72	755	27	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	755	28	as	as	IN
cord-001859-d62iuk72	755	29	a	a	DT
cord-001859-d62iuk72	755	30	host	host	NN
cord-001859-d62iuk72	755	31	chaperone	chaperone	NN
cord-001859-d62iuk72	755	32	required	require	VBN
cord-001859-d62iuk72	755	33	for	for	IN
cord-001859-d62iuk72	755	34	viral	viral	JJ
cord-001859-d62iuk72	755	35	replication	replication	NN
cord-001859-d62iuk72	755	36	Recruitment	Recruitment	NNP
cord-001859-d62iuk72	755	37	of	of	IN
cord-001859-d62iuk72	755	38	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	755	39	chaperones	chaperone	NNS
cord-001859-d62iuk72	755	40	:	:	:
cord-001859-d62iuk72	755	41	a	a	DT
cord-001859-d62iuk72	755	42	crucial	crucial	JJ
cord-001859-d62iuk72	755	43	part	part	NN
cord-001859-d62iuk72	755	44	of	of	IN
cord-001859-d62iuk72	755	45	viral	viral	JJ
cord-001859-d62iuk72	755	46	survival	survival	NN
cord-001859-d62iuk72	755	47	strategies	strategy	NNS
cord-001859-d62iuk72	755	48	Evolution	Evolution	NNP
cord-001859-d62iuk72	755	49	of	of	IN
cord-001859-d62iuk72	755	50	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	755	51	Gene	Gene	NNP
cord-001859-d62iuk72	755	52	and	and	CC
cord-001859-d62iuk72	755	53	Its	-PRON-	PRP$
cord-001859-d62iuk72	755	54	Implications	implication	NNS
cord-001859-d62iuk72	756	1	Regarding	regard	VBG
cord-001859-d62iuk72	756	2	Relationships	relationship	NNS
cord-001859-d62iuk72	756	3	between	between	IN
cord-001859-d62iuk72	756	4	Archaebacteria	Archaebacteria	NNP
cord-001859-d62iuk72	756	5	,	,	,
cord-001859-d62iuk72	756	6	Eubacteria	Eubacteria	NNP
cord-001859-d62iuk72	756	7	,	,	,
cord-001859-d62iuk72	756	8	and	and	CC
cord-001859-d62iuk72	756	9	Eukaryotes	eukaryote	NNS
cord-001859-d62iuk72	757	1	The	the	DT
cord-001859-d62iuk72	757	2	Heat	Heat	NNP
cord-001859-d62iuk72	757	3	Shock	shock	NN
cord-001859-d62iuk72	757	4	Proteins	Proteins	NNP
cord-001859-d62iuk72	757	5	Phylogenetic	Phylogenetic	NNP
cord-001859-d62iuk72	757	6	Analysis	Analysis	NNP
cord-001859-d62iuk72	757	7	of	of	IN
cord-001859-d62iuk72	757	8	70	70	CD
cord-001859-d62iuk72	757	9	Kd	Kd	NNP
cord-001859-d62iuk72	757	10	Heat	Heat	NNP
cord-001859-d62iuk72	757	11	Shock	Shock	NNP
cord-001859-d62iuk72	757	12	Protein	Protein	NNP
cord-001859-d62iuk72	757	13	Sequences	Sequences	NNPS
cord-001859-d62iuk72	757	14	Suggests	suggest	VBZ
cord-001859-d62iuk72	757	15	a	a	DT
cord-001859-d62iuk72	757	16	Chimeric	chimeric	JJ
cord-001859-d62iuk72	757	17	Origin	Origin	NNP
cord-001859-d62iuk72	757	18	for	for	IN
cord-001859-d62iuk72	757	19	the	the	DT
cord-001859-d62iuk72	757	20	Eukaryotic	Eukaryotic	NNP
cord-001859-d62iuk72	757	21	Cell	Cell	NNP
cord-001859-d62iuk72	757	22	Nucleus	Nucleus	NNP
cord-001859-d62iuk72	757	23	ATPases	atpase	NNS
cord-001859-d62iuk72	757	24	as	as	IN
cord-001859-d62iuk72	757	25	Drug	Drug	NNP
cord-001859-d62iuk72	757	26	Targets	Targets	NNPS
cord-001859-d62iuk72	757	27	:	:	:
cord-001859-d62iuk72	758	1	Insights	insight	NNS
cord-001859-d62iuk72	758	2	from	from	IN
cord-001859-d62iuk72	758	3	Heat	Heat	NNP
cord-001859-d62iuk72	758	4	Shock	Shock	NNP
cord-001859-d62iuk72	758	5	Proteins	protein	VBZ
cord-001859-d62iuk72	758	6	70	70	CD
cord-001859-d62iuk72	758	7	and	and	CC
cord-001859-d62iuk72	758	8	90	90	CD
cord-001859-d62iuk72	759	1	Targeting	target	VBG
cord-001859-d62iuk72	759	2	HSP70	HSP70	NNP
cord-001859-d62iuk72	760	1	The	the	DT
cord-001859-d62iuk72	760	2	second	second	JJ
cord-001859-d62iuk72	760	3	potentially	potentially	RB
cord-001859-d62iuk72	760	4	druggable	druggable	JJ
cord-001859-d62iuk72	760	5	heat	heat	NN
cord-001859-d62iuk72	760	6	shock	shock	NN
cord-001859-d62iuk72	760	7	protein	protein	NN
cord-001859-d62iuk72	760	8	and	and	CC
cord-001859-d62iuk72	760	9	molecular	molecular	JJ
cord-001859-d62iuk72	760	10	chaperone	chaperone	NN
cord-001859-d62iuk72	760	11	?	?	.
cord-001859-d62iuk72	761	1	Update	update	NN
cord-001859-d62iuk72	761	2	on	on	IN
cord-001859-d62iuk72	761	3	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	761	4	Inhibitors	Inhibitors	NNP
cord-001859-d62iuk72	761	5	in	in	IN
cord-001859-d62iuk72	761	6	Clinical	Clinical	NNP
cord-001859-d62iuk72	761	7	Trial	Trial	NNP
cord-001859-d62iuk72	761	8	Advances	Advances	NNPS
cord-001859-d62iuk72	761	9	in	in	IN
cord-001859-d62iuk72	761	10	the	the	DT
cord-001859-d62iuk72	761	11	clinical	clinical	JJ
cord-001859-d62iuk72	761	12	development	development	NN
cord-001859-d62iuk72	761	13	of	of	IN
cord-001859-d62iuk72	761	14	heat	heat	NN
cord-001859-d62iuk72	761	15	shock	shock	NN
cord-001859-d62iuk72	761	16	protein	protein	NN
cord-001859-d62iuk72	761	17	90	90	CD
cord-001859-d62iuk72	761	18	(	(	-LRB-
cord-001859-d62iuk72	761	19	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	761	20	)	)	-RRB-
cord-001859-d62iuk72	761	21	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	761	22	in	in	IN
cord-001859-d62iuk72	761	23	cancers	cancer	NNS
cord-001859-d62iuk72	761	24	Phase	Phase	NNP
cord-001859-d62iuk72	761	25	-	-	HYPH
cord-001859-d62iuk72	761	26	II	II	NNP
cord-001859-d62iuk72	761	27	Study	Study	NNP
cord-001859-d62iuk72	761	28	of	of	IN
cord-001859-d62iuk72	761	29	Deoxyspergualin	Deoxyspergualin	NNP
cord-001859-d62iuk72	761	30	in	in	IN
cord-001859-d62iuk72	761	31	Metastatic	Metastatic	NNP
cord-001859-d62iuk72	761	32	Breast	Breast	NNP
cord-001859-d62iuk72	761	33	Cancer	Cancer	NNP
cord-001859-d62iuk72	761	34	.	.	.
cord-001859-d62iuk72	762	1	Invest	invest	VB
cord-001859-d62iuk72	762	2	New	New	NNP
cord-001859-d62iuk72	762	3	Drug	Drug	NNP
cord-001859-d62iuk72	762	4	Tau	Tau	NNP
cord-001859-d62iuk72	762	5	aggregation	aggregation	NN
cord-001859-d62iuk72	762	6	inhibitor	inhibitor	NN
cord-001859-d62iuk72	762	7	(	(	-LRB-
cord-001859-d62iuk72	762	8	TAI	TAI	NNP
cord-001859-d62iuk72	762	9	)	)	-RRB-
cord-001859-d62iuk72	762	10	therapy	therapy	NN
cord-001859-d62iuk72	762	11	with	with	IN
cord-001859-d62iuk72	762	12	rember	rember	NNP
cord-001859-d62iuk72	762	13	arrests	arrest	VBZ
cord-001859-d62iuk72	762	14	disease	disease	NN
cord-001859-d62iuk72	762	15	progression	progression	NN
cord-001859-d62iuk72	762	16	in	in	IN
cord-001859-d62iuk72	762	17	mild	mild	JJ
cord-001859-d62iuk72	762	18	and	and	CC
cord-001859-d62iuk72	762	19	moderate	moderate	JJ
cord-001859-d62iuk72	762	20	Alzheimer	Alzheimer	NNP
cord-001859-d62iuk72	762	21	's	's	POS
cord-001859-d62iuk72	762	22	disease	disease	NN
cord-001859-d62iuk72	762	23	over	over	IN
cord-001859-d62iuk72	762	24	50	50	CD
cord-001859-d62iuk72	762	25	weeks	week	NNS
cord-001859-d62iuk72	762	26	KSHV	KSHV	NNP
cord-001859-d62iuk72	762	27	and	and	CC
cord-001859-d62iuk72	762	28	the	the	DT
cord-001859-d62iuk72	762	29	pathogenesis	pathogenesis	NN
cord-001859-d62iuk72	762	30	of	of	IN
cord-001859-d62iuk72	762	31	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	762	32	sarcoma	sarcoma	NN
cord-001859-d62iuk72	762	33	:	:	:
cord-001859-d62iuk72	762	34	listening	listen	VBG
cord-001859-d62iuk72	762	35	to	to	IN
cord-001859-d62iuk72	762	36	human	human	JJ
cord-001859-d62iuk72	762	37	biology	biology	NN
cord-001859-d62iuk72	762	38	and	and	CC
cord-001859-d62iuk72	762	39	medicine	medicine	NN
cord-001859-d62iuk72	762	40	KSHV	KSHV	NNP
cord-001859-d62iuk72	762	41	infection	infection	NN
cord-001859-d62iuk72	762	42	and	and	CC
cord-001859-d62iuk72	762	43	the	the	DT
cord-001859-d62iuk72	762	44	pathogenesis	pathogenesis	NN
cord-001859-d62iuk72	762	45	of	of	IN
cord-001859-d62iuk72	762	46	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	762	47	's	's	POS
cord-001859-d62iuk72	762	48	sarcoma	sarcoma	NN
cord-001859-d62iuk72	762	49	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	762	50	's	's	POS
cord-001859-d62iuk72	762	51	sarcoma	sarcoma	NN
cord-001859-d62iuk72	762	52	and	and	CC
cord-001859-d62iuk72	762	53	its	-PRON-	PRP$
cord-001859-d62iuk72	762	54	associated	associated	JJ
cord-001859-d62iuk72	762	55	herpesvirus	herpesvirus	NNP
cord-001859-d62iuk72	762	56	X	x	NN
cord-001859-d62iuk72	762	57	box	box	NN
cord-001859-d62iuk72	762	58	binding	bind	VBG
cord-001859-d62iuk72	762	59	protein	protein	NN
cord-001859-d62iuk72	762	60	XBP-1s	XBP-1s	NNP
cord-001859-d62iuk72	762	61	transactivates	transactivate	VBZ
cord-001859-d62iuk72	762	62	the	the	DT
cord-001859-d62iuk72	762	63	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	762	64	's	's	POS
cord-001859-d62iuk72	762	65	sarcoma	sarcoma	NN
cord-001859-d62iuk72	762	66	-	-	HYPH
cord-001859-d62iuk72	762	67	associated	associate	VBN
cord-001859-d62iuk72	762	68	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	762	69	(	(	-LRB-
cord-001859-d62iuk72	762	70	KSHV	KSHV	NNP
cord-001859-d62iuk72	762	71	)	)	-RRB-
cord-001859-d62iuk72	762	72	ORF50	ORF50	NNP
cord-001859-d62iuk72	762	73	promoter	promoter	NN
cord-001859-d62iuk72	762	74	,	,	,
cord-001859-d62iuk72	762	75	linking	link	VBG
cord-001859-d62iuk72	762	76	plasma	plasma	NN
cord-001859-d62iuk72	762	77	cell	cell	NN
cord-001859-d62iuk72	762	78	differentiation	differentiation	NN
cord-001859-d62iuk72	762	79	to	to	IN
cord-001859-d62iuk72	762	80	KSHV	KSHV	NNP
cord-001859-d62iuk72	762	81	reactivation	reactivation	NN
cord-001859-d62iuk72	762	82	from	from	IN
cord-001859-d62iuk72	762	83	latency	latency	NNP
cord-001859-d62iuk72	762	84	A	a	DT
cord-001859-d62iuk72	762	85	Novel	Novel	NNP
cord-001859-d62iuk72	762	86	Mechanism	Mechanism	NNP
cord-001859-d62iuk72	762	87	Inducing	induce	VBG
cord-001859-d62iuk72	762	88	Genome	Genome	NNP
cord-001859-d62iuk72	762	89	Instability	instability	NN
cord-001859-d62iuk72	762	90	in	in	IN
cord-001859-d62iuk72	762	91	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	762	92	's	's	POS
cord-001859-d62iuk72	762	93	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	762	94	-	-	HYPH
cord-001859-d62iuk72	762	95	Associated	Associated	NNP
cord-001859-d62iuk72	762	96	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	762	97	Infected	Infected	NNP
cord-001859-d62iuk72	762	98	Cells	cell	NNS
cord-001859-d62iuk72	763	1	Inefficient	inefficient	JJ
cord-001859-d62iuk72	763	2	establishment	establishment	NN
cord-001859-d62iuk72	763	3	of	of	IN
cord-001859-d62iuk72	763	4	KSHV	KSHV	NNP
cord-001859-d62iuk72	763	5	latency	latency	NNP
cord-001859-d62iuk72	763	6	suggests	suggest	VBZ
cord-001859-d62iuk72	763	7	an	an	DT
cord-001859-d62iuk72	763	8	additional	additional	JJ
cord-001859-d62iuk72	763	9	role	role	NN
cord-001859-d62iuk72	763	10	for	for	IN
cord-001859-d62iuk72	763	11	continued	continued	JJ
cord-001859-d62iuk72	763	12	lytic	lytic	JJ
cord-001859-d62iuk72	763	13	replication	replication	NN
cord-001859-d62iuk72	763	14	in	in	IN
cord-001859-d62iuk72	763	15	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	763	16	sarcoma	sarcoma	NN
cord-001859-d62iuk72	763	17	pathogenesis	pathogenesis	NN
cord-001859-d62iuk72	763	18	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	763	19	Saimiri	Saimiri	NNP
cord-001859-d62iuk72	763	20	open	open	JJ
cord-001859-d62iuk72	763	21	reading	reading	NN
cord-001859-d62iuk72	763	22	frame	frame	NN
cord-001859-d62iuk72	763	23	50	50	CD
cord-001859-d62iuk72	764	1	(	(	-LRB-
cord-001859-d62iuk72	764	2	Rta	Rta	NNP
cord-001859-d62iuk72	764	3	)	)	-RRB-
cord-001859-d62iuk72	764	4	protein	protein	NN
cord-001859-d62iuk72	764	5	reactivates	reactivate	VBZ
cord-001859-d62iuk72	764	6	the	the	DT
cord-001859-d62iuk72	764	7	lytic	lytic	JJ
cord-001859-d62iuk72	764	8	replication	replication	NN
cord-001859-d62iuk72	764	9	cycle	cycle	NN
cord-001859-d62iuk72	764	10	in	in	IN
cord-001859-d62iuk72	764	11	a	a	DT
cord-001859-d62iuk72	764	12	persistently	persistently	RB
cord-001859-d62iuk72	764	13	infected	infected	JJ
cord-001859-d62iuk72	764	14	A549	a549	JJ
cord-001859-d62iuk72	764	15	cell	cell	NN
cord-001859-d62iuk72	764	16	line	line	NN
cord-001859-d62iuk72	764	17	Reactivation	reactivation	NN
cord-001859-d62iuk72	764	18	of	of	IN
cord-001859-d62iuk72	764	19	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	764	20	's	's	POS
cord-001859-d62iuk72	764	21	sarcoma	sarcoma	NN
cord-001859-d62iuk72	764	22	-	-	HYPH
cord-001859-d62iuk72	764	23	associated	associate	VBN
cord-001859-d62iuk72	764	24	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	764	25	infection	infection	NN
cord-001859-d62iuk72	764	26	from	from	IN
cord-001859-d62iuk72	764	27	latency	latency	NN
cord-001859-d62iuk72	764	28	by	by	IN
cord-001859-d62iuk72	764	29	expression	expression	NN
cord-001859-d62iuk72	764	30	of	of	IN
cord-001859-d62iuk72	764	31	the	the	DT
cord-001859-d62iuk72	764	32	ORF	ORF	NNP
cord-001859-d62iuk72	764	33	50	50	CD
cord-001859-d62iuk72	764	34	transactivator	transactivator	NNP
cord-001859-d62iuk72	764	35	,	,	,
cord-001859-d62iuk72	764	36	a	a	DT
cord-001859-d62iuk72	764	37	homolog	homolog	NN
cord-001859-d62iuk72	764	38	of	of	IN
cord-001859-d62iuk72	764	39	the	the	DT
cord-001859-d62iuk72	764	40	EBV	EBV	NNP
cord-001859-d62iuk72	764	41	R	R	NNP
cord-001859-d62iuk72	764	42	protein	protein	NN
cord-001859-d62iuk72	764	43	DNA	dna	NN
cord-001859-d62iuk72	764	44	Virus	virus	NN
cord-001859-d62iuk72	764	45	Replication	replication	NN
cord-001859-d62iuk72	764	46	Compartments	compartment	NNS
cord-001859-d62iuk72	765	1	A	a	DT
cord-001859-d62iuk72	765	2	dominant	dominant	JJ
cord-001859-d62iuk72	765	3	-	-	HYPH
cord-001859-d62iuk72	765	4	negative	negative	JJ
cord-001859-d62iuk72	765	5	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	765	6	protein	protein	NN
cord-001859-d62iuk72	765	7	inhibits	inhibit	VBZ
cord-001859-d62iuk72	765	8	intranuclear	intranuclear	NNP
cord-001859-d62iuk72	765	9	targeting	target	VBG
cord-001859-d62iuk72	765	10	of	of	IN
cord-001859-d62iuk72	765	11	viral	viral	JJ
cord-001859-d62iuk72	765	12	proteins	protein	NNS
cord-001859-d62iuk72	765	13	:	:	:
cord-001859-d62iuk72	765	14	Effects	effect	NNS
cord-001859-d62iuk72	765	15	on	on	IN
cord-001859-d62iuk72	765	16	DNA	dna	NN
cord-001859-d62iuk72	765	17	replication	replication	NN
cord-001859-d62iuk72	765	18	and	and	CC
cord-001859-d62iuk72	765	19	late	late	JJ
cord-001859-d62iuk72	765	20	gene	gene	NN
cord-001859-d62iuk72	765	21	expression	expression	NN
cord-001859-d62iuk72	765	22	Annexation	annexation	NN
cord-001859-d62iuk72	765	23	of	of	IN
cord-001859-d62iuk72	765	24	the	the	DT
cord-001859-d62iuk72	765	25	interchromosomal	interchromosomal	JJ
cord-001859-d62iuk72	765	26	space	space	NN
cord-001859-d62iuk72	765	27	during	during	IN
cord-001859-d62iuk72	765	28	viral	viral	JJ
cord-001859-d62iuk72	765	29	infection	infection	NN
cord-001859-d62iuk72	765	30	Herpes	Herpes	NNP
cord-001859-d62iuk72	765	31	simplex	simplex	NN
cord-001859-d62iuk72	765	32	virus	virus	NN
cord-001859-d62iuk72	765	33	replication	replication	NN
cord-001859-d62iuk72	765	34	compartments	compartment	NNS
cord-001859-d62iuk72	765	35	can	can	MD
cord-001859-d62iuk72	765	36	form	form	VB
cord-001859-d62iuk72	765	37	by	by	IN
cord-001859-d62iuk72	765	38	coalescence	coalescence	NN
cord-001859-d62iuk72	765	39	of	of	IN
cord-001859-d62iuk72	765	40	smaller	small	JJR
cord-001859-d62iuk72	765	41	compartments	compartment	NNS
cord-001859-d62iuk72	765	42	Architecture	architecture	NN
cord-001859-d62iuk72	765	43	of	of	IN
cord-001859-d62iuk72	765	44	replication	replication	NN
cord-001859-d62iuk72	765	45	compartments	compartment	NNS
cord-001859-d62iuk72	765	46	formed	form	VBN
cord-001859-d62iuk72	765	47	during	during	IN
cord-001859-d62iuk72	765	48	Epstein	Epstein	NNP
cord-001859-d62iuk72	765	49	-	-	HYPH
cord-001859-d62iuk72	765	50	Barr	Barr	NNP
cord-001859-d62iuk72	765	51	virus	virus	NN
cord-001859-d62iuk72	765	52	lytic	lytic	JJ
cord-001859-d62iuk72	765	53	replication	replication	NN
cord-001859-d62iuk72	765	54	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	765	55	's	's	POS
cord-001859-d62iuk72	765	56	sarcoma	sarcoma	NN
cord-001859-d62iuk72	765	57	-	-	HYPH
cord-001859-d62iuk72	765	58	associated	associate	VBN
cord-001859-d62iuk72	765	59	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	765	60	ori	ori	NNP
cord-001859-d62iuk72	765	61	-	-	HYPH
cord-001859-d62iuk72	765	62	Lyt	Lyt	NNP
cord-001859-d62iuk72	765	63	-	-	HYPH
cord-001859-d62iuk72	765	64	dependent	dependent	JJ
cord-001859-d62iuk72	765	65	DNA	dna	NN
cord-001859-d62iuk72	765	66	replication	replication	NN
cord-001859-d62iuk72	765	67	:	:	:
cord-001859-d62iuk72	765	68	involvement	involvement	NN
cord-001859-d62iuk72	765	69	of	of	IN
cord-001859-d62iuk72	765	70	host	host	NN
cord-001859-d62iuk72	765	71	cellular	cellular	JJ
cord-001859-d62iuk72	765	72	factors	factor	NNS
cord-001859-d62iuk72	765	73	Proteomics	Proteomics	NNP
cord-001859-d62iuk72	765	74	of	of	IN
cord-001859-d62iuk72	765	75	herpes	herpes	NNP
cord-001859-d62iuk72	765	76	simplex	simplex	NNP
cord-001859-d62iuk72	765	77	virus	virus	NN
cord-001859-d62iuk72	765	78	replication	replication	NN
cord-001859-d62iuk72	765	79	compartments	compartment	NNS
cord-001859-d62iuk72	765	80	:	:	:
cord-001859-d62iuk72	765	81	Association	Association	NNP
cord-001859-d62iuk72	765	82	of	of	IN
cord-001859-d62iuk72	765	83	cellular	cellular	JJ
cord-001859-d62iuk72	765	84	DNA	dna	NN
cord-001859-d62iuk72	765	85	replication	replication	NN
cord-001859-d62iuk72	765	86	,	,	,
cord-001859-d62iuk72	765	87	repair	repair	NN
cord-001859-d62iuk72	765	88	,	,	,
cord-001859-d62iuk72	765	89	recombination	recombination	NN
cord-001859-d62iuk72	765	90	,	,	,
cord-001859-d62iuk72	765	91	and	and	CC
cord-001859-d62iuk72	765	92	chromatin	chromatin	NN
cord-001859-d62iuk72	765	93	remodeling	remodeling	NN
cord-001859-d62iuk72	765	94	proteins	protein	NNS
cord-001859-d62iuk72	765	95	with	with	IN
cord-001859-d62iuk72	765	96	ICP8	ICP8	NNP
cord-001859-d62iuk72	765	97	Using	use	VBG
cord-001859-d62iuk72	765	98	SILAC	SILAC	NNP
cord-001859-d62iuk72	765	99	and	and	CC
cord-001859-d62iuk72	765	100	quantitative	quantitative	JJ
cord-001859-d62iuk72	765	101	proteomics	proteomic	NNS
cord-001859-d62iuk72	765	102	to	to	TO
cord-001859-d62iuk72	765	103	investigate	investigate	VB
cord-001859-d62iuk72	765	104	the	the	DT
cord-001859-d62iuk72	765	105	interactions	interaction	NNS
cord-001859-d62iuk72	765	106	between	between	IN
cord-001859-d62iuk72	765	107	viral	viral	JJ
cord-001859-d62iuk72	765	108	and	and	CC
cord-001859-d62iuk72	765	109	host	host	NN
cord-001859-d62iuk72	765	110	proteomes	proteome	NNS
cord-001859-d62iuk72	765	111	Nucleolar	Nucleolar	NNP
cord-001859-d62iuk72	765	112	proteomics	proteomic	NNS
cord-001859-d62iuk72	765	113	and	and	CC
cord-001859-d62iuk72	765	114	viral	viral	JJ
cord-001859-d62iuk72	765	115	infection	infection	NN
cord-001859-d62iuk72	765	116	Use	use	NN
cord-001859-d62iuk72	765	117	of	of	IN
cord-001859-d62iuk72	765	118	Sequential	sequential	JJ
cord-001859-d62iuk72	765	119	Chemical	Chemical	NNP
cord-001859-d62iuk72	765	120	Extractions	extraction	NNS
cord-001859-d62iuk72	765	121	to	to	TO
cord-001859-d62iuk72	765	122	Purify	purify	VB
cord-001859-d62iuk72	765	123	Nuclear	nuclear	JJ
cord-001859-d62iuk72	765	124	Membrane	membrane	NN
cord-001859-d62iuk72	765	125	Proteins	protein	NNS
cord-001859-d62iuk72	765	126	for	for	IN
cord-001859-d62iuk72	765	127	Proteomics	Proteomics	NNP
cord-001859-d62iuk72	765	128	Identification	Identification	NNP
cord-001859-d62iuk72	765	129	Coupling	Coupling	NNP
cord-001859-d62iuk72	765	130	of	of	IN
cord-001859-d62iuk72	765	131	the	the	DT
cord-001859-d62iuk72	765	132	nucleus	nucleus	NN
cord-001859-d62iuk72	765	133	and	and	CC
cord-001859-d62iuk72	765	134	cytoplasm	cytoplasm	NN
cord-001859-d62iuk72	765	135	:	:	:
cord-001859-d62iuk72	765	136	role	role	NN
cord-001859-d62iuk72	765	137	of	of	IN
cord-001859-d62iuk72	765	138	the	the	DT
cord-001859-d62iuk72	765	139	LINC	LINC	NNP
cord-001859-d62iuk72	765	140	complex	complex	JJ
cord-001859-d62iuk72	765	141	Role	role	NN
cord-001859-d62iuk72	765	142	of	of	IN
cord-001859-d62iuk72	765	143	ANC-1	ANC-1	NNP
cord-001859-d62iuk72	765	144	in	in	IN
cord-001859-d62iuk72	765	145	tethering	tether	VBG
cord-001859-d62iuk72	765	146	nuclei	nucleus	NNS
cord-001859-d62iuk72	765	147	to	to	IN
cord-001859-d62iuk72	765	148	the	the	DT
cord-001859-d62iuk72	765	149	actin	actin	NN
cord-001859-d62iuk72	765	150	cytoskeleton	cytoskeleton	NN
cord-001859-d62iuk72	765	151	Dynamic	dynamic	JJ
cord-001859-d62iuk72	765	152	interactions	interaction	NNS
cord-001859-d62iuk72	765	153	of	of	IN
cord-001859-d62iuk72	765	154	nuclear	nuclear	JJ
cord-001859-d62iuk72	765	155	lamina	lamina	NN
cord-001859-d62iuk72	765	156	proteins	protein	NNS
cord-001859-d62iuk72	765	157	with	with	IN
cord-001859-d62iuk72	765	158	chromatin	chromatin	NN
cord-001859-d62iuk72	765	159	and	and	CC
cord-001859-d62iuk72	765	160	transcriptional	transcriptional	JJ
cord-001859-d62iuk72	765	161	machinery	machinery	NN
cord-001859-d62iuk72	765	162	Nuclear	nuclear	JJ
cord-001859-d62iuk72	765	163	lamins	lamin	NNS
cord-001859-d62iuk72	765	164	:	:	:
cord-001859-d62iuk72	765	165	Their	-PRON-	PRP$
cord-001859-d62iuk72	765	166	structure	structure	NN
cord-001859-d62iuk72	765	167	,	,	,
cord-001859-d62iuk72	765	168	assembly	assembly	NN
cord-001859-d62iuk72	765	169	,	,	,
cord-001859-d62iuk72	765	170	and	and	CC
cord-001859-d62iuk72	765	171	interactions	interaction	VBZ
cord-001859-d62iuk72	765	172	Histones	Histones	NNP
cord-001859-d62iuk72	765	173	H3	H3	NNP
cord-001859-d62iuk72	765	174	/	/	SYM
cord-001859-d62iuk72	765	175	H4	H4	NNP
cord-001859-d62iuk72	765	176	form	form	VB
cord-001859-d62iuk72	765	177	a	a	DT
cord-001859-d62iuk72	765	178	tight	tight	JJ
cord-001859-d62iuk72	765	179	complex	complex	NN
cord-001859-d62iuk72	765	180	with	with	IN
cord-001859-d62iuk72	765	181	the	the	DT
cord-001859-d62iuk72	765	182	inner	inner	JJ
cord-001859-d62iuk72	765	183	nuclear	nuclear	JJ
cord-001859-d62iuk72	765	184	membrane	membrane	NN
cord-001859-d62iuk72	765	185	protein	protein	NN
cord-001859-d62iuk72	765	186	LBR	LBR	NNP
cord-001859-d62iuk72	765	187	and	and	CC
cord-001859-d62iuk72	765	188	heterochromatin	heterochromatin	NN
cord-001859-d62iuk72	765	189	protein	protein	NN
cord-001859-d62iuk72	766	1	1	1	LS
cord-001859-d62iuk72	766	2	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	766	3	Inhibitors	Inhibitors	NNP
cord-001859-d62iuk72	766	4	Are	be	VBP
cord-001859-d62iuk72	766	5	Efficacious	efficacious	JJ
cord-001859-d62iuk72	766	6	against	against	IN
cord-001859-d62iuk72	766	7	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	766	8	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	766	9	by	by	IN
cord-001859-d62iuk72	766	10	Enhancing	enhance	VBG
cord-001859-d62iuk72	766	11	the	the	DT
cord-001859-d62iuk72	766	12	Degradation	degradation	NN
cord-001859-d62iuk72	766	13	of	of	IN
cord-001859-d62iuk72	766	14	the	the	DT
cord-001859-d62iuk72	766	15	Essential	Essential	NNP
cord-001859-d62iuk72	766	16	Viral	Viral	NNP
cord-001859-d62iuk72	766	17	Gene	Gene	NNP
cord-001859-d62iuk72	766	18	LANA	LANA	NNP
cord-001859-d62iuk72	766	19	,	,	,
cord-001859-d62iuk72	766	20	of	of	IN
cord-001859-d62iuk72	766	21	the	the	DT
cord-001859-d62iuk72	766	22	Viral	Viral	NNP
cord-001859-d62iuk72	766	23	Co	Co	NNP
cord-001859-d62iuk72	766	24	-	-	HYPH
cord-001859-d62iuk72	766	25	Receptor	Receptor	NNP
cord-001859-d62iuk72	766	26	EphA2	EphA2	NNP
cord-001859-d62iuk72	766	27	as	as	RB
cord-001859-d62iuk72	766	28	well	well	RB
cord-001859-d62iuk72	766	29	as	as	IN
cord-001859-d62iuk72	766	30	Other	other	JJ
cord-001859-d62iuk72	766	31	Client	Client	NNP
cord-001859-d62iuk72	766	32	Proteins	protein	NNS
cord-001859-d62iuk72	766	33	Use	Use	NNP
cord-001859-d62iuk72	766	34	of	of	IN
cord-001859-d62iuk72	766	35	the	the	DT
cord-001859-d62iuk72	766	36	red	red	JJ
cord-001859-d62iuk72	766	37	fluorescent	fluorescent	NN
cord-001859-d62iuk72	766	38	protein	protein	NN
cord-001859-d62iuk72	766	39	as	as	IN
cord-001859-d62iuk72	766	40	a	a	DT
cord-001859-d62iuk72	766	41	marker	marker	NN
cord-001859-d62iuk72	766	42	of	of	IN
cord-001859-d62iuk72	766	43	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	766	44	's	's	POS
cord-001859-d62iuk72	766	45	sarcoma	sarcoma	NN
cord-001859-d62iuk72	766	46	-	-	HYPH
cord-001859-d62iuk72	766	47	associated	associate	VBN
cord-001859-d62iuk72	766	48	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	766	49	lytic	lytic	JJ
cord-001859-d62iuk72	766	50	gene	gene	NN
cord-001859-d62iuk72	766	51	expression	expression	NN
cord-001859-d62iuk72	766	52	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	766	53	's	's	POS
cord-001859-d62iuk72	766	54	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	766	55	-	-	HYPH
cord-001859-d62iuk72	766	56	Associated	Associated	NNP
cord-001859-d62iuk72	766	57	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	766	58	ORF57	ORF57	NNP
cord-001859-d62iuk72	766	59	Protein	protein	NN
cord-001859-d62iuk72	766	60	:	:	:
cord-001859-d62iuk72	767	1	Exploiting	exploit	VBG
cord-001859-d62iuk72	767	2	All	all	DT
cord-001859-d62iuk72	767	3	Stages	stage	NNS
cord-001859-d62iuk72	767	4	of	of	IN
cord-001859-d62iuk72	767	5	Viral	Viral	NNP
cord-001859-d62iuk72	767	6	mRNA	mRNA	NNP
cord-001859-d62iuk72	767	7	Processing	processing	NN
cord-001859-d62iuk72	767	8	NEDDylation	neddylation	NN
cord-001859-d62iuk72	767	9	Is	be	VBZ
cord-001859-d62iuk72	767	10	Essential	essential	JJ
cord-001859-d62iuk72	767	11	for	for	IN
cord-001859-d62iuk72	767	12	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	767	13	's	's	POS
cord-001859-d62iuk72	767	14	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	767	15	-	-	HYPH
cord-001859-d62iuk72	767	16	Associated	Associated	NNP
cord-001859-d62iuk72	767	17	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	767	18	Latency	Latency	NNP
cord-001859-d62iuk72	767	19	and	and	CC
cord-001859-d62iuk72	767	20	Lytic	Lytic	NNP
cord-001859-d62iuk72	767	21	Reactivation	Reactivation	NNP
cord-001859-d62iuk72	767	22	and	and	CC
cord-001859-d62iuk72	767	23	Represents	represent	VBZ
cord-001859-d62iuk72	767	24	a	a	DT
cord-001859-d62iuk72	767	25	Novel	Novel	NNP
cord-001859-d62iuk72	767	26	Anti	Anti	NNP
cord-001859-d62iuk72	767	27	-	-	NNP
cord-001859-d62iuk72	767	28	KSHV	KSHV	NNP
cord-001859-d62iuk72	767	29	Target	Target	NNP
cord-001859-d62iuk72	767	30	Interaction	Interaction	NNP
cord-001859-d62iuk72	767	31	Network	Network	NNP
cord-001859-d62iuk72	767	32	of	of	IN
cord-001859-d62iuk72	767	33	Proteins	Proteins	NNP
cord-001859-d62iuk72	767	34	Associated	Associated	NNP
cord-001859-d62iuk72	767	35	with	with	IN
cord-001859-d62iuk72	767	36	Human	Human	NNP
cord-001859-d62iuk72	767	37	Cytomegalovirus	Cytomegalovirus	NNP
cord-001859-d62iuk72	767	38	IE2-p86	IE2-p86	NNP
cord-001859-d62iuk72	767	39	Protein	Protein	NNP
cord-001859-d62iuk72	767	40	during	during	IN
cord-001859-d62iuk72	767	41	Infection	Infection	NNP
cord-001859-d62iuk72	767	42	:	:	:
cord-001859-d62iuk72	768	1	A	a	DT
cord-001859-d62iuk72	768	2	Proteomic	Proteomic	NNP
cord-001859-d62iuk72	768	3	Analysis	Analysis	NNP
cord-001859-d62iuk72	768	4	Human	Human	NNP
cord-001859-d62iuk72	768	5	cytomegalovirus	cytomegalovirus	NN
cord-001859-d62iuk72	768	6	induces	induce	VBZ
cord-001859-d62iuk72	768	7	expression	expression	NN
cord-001859-d62iuk72	768	8	of	of	IN
cord-001859-d62iuk72	768	9	cellular	cellular	JJ
cord-001859-d62iuk72	768	10	topoisomerase	topoisomerase	NN
cord-001859-d62iuk72	768	11	II	II	NNP
cord-001859-d62iuk72	768	12	Herpes	Herpes	NNP
cord-001859-d62iuk72	768	13	simplex	simplex	NN
cord-001859-d62iuk72	768	14	virus	virus	NN
cord-001859-d62iuk72	768	15	1	1	CD
cord-001859-d62iuk72	768	16	activates	activate	VBZ
cord-001859-d62iuk72	768	17	cdc2	cdc2	NN
cord-001859-d62iuk72	768	18	to	to	TO
cord-001859-d62iuk72	768	19	recruit	recruit	VB
cord-001859-d62iuk72	768	20	topoisomerase	topoisomerase	NN
cord-001859-d62iuk72	768	21	II	ii	CD
cord-001859-d62iuk72	768	22	alpha	alpha	NN
cord-001859-d62iuk72	768	23	for	for	IN
cord-001859-d62iuk72	768	24	post	post	JJ
cord-001859-d62iuk72	768	25	-	-	JJ
cord-001859-d62iuk72	768	26	DNA	dna	JJ
cord-001859-d62iuk72	768	27	synthesis	synthesis	NN
cord-001859-d62iuk72	768	28	expression	expression	NN
cord-001859-d62iuk72	768	29	of	of	IN
cord-001859-d62iuk72	768	30	late	late	JJ
cord-001859-d62iuk72	768	31	genes	gene	NNS
cord-001859-d62iuk72	769	1	Global	global	JJ
cord-001859-d62iuk72	769	2	changes	change	NNS
cord-001859-d62iuk72	769	3	in	in	IN
cord-001859-d62iuk72	769	4	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	769	5	's	's	POS
cord-001859-d62iuk72	769	6	sarcomaassociated	sarcomaassociate	VBN
cord-001859-d62iuk72	769	7	virus	virus	NN
cord-001859-d62iuk72	769	8	gene	gene	NN
cord-001859-d62iuk72	769	9	expression	expression	NN
cord-001859-d62iuk72	769	10	patterns	pattern	NNS
cord-001859-d62iuk72	769	11	following	follow	VBG
cord-001859-d62iuk72	769	12	expression	expression	NN
cord-001859-d62iuk72	769	13	of	of	IN
cord-001859-d62iuk72	769	14	a	a	DT
cord-001859-d62iuk72	769	15	tetracycline	tetracycline	NN
cord-001859-d62iuk72	769	16	-	-	HYPH
cord-001859-d62iuk72	769	17	inducible	inducible	JJ
cord-001859-d62iuk72	769	18	Rta	Rta	NNP
cord-001859-d62iuk72	769	19	transactivator	transactivator	NN
cord-001859-d62iuk72	769	20	Dynamic	Dynamic	NNP
cord-001859-d62iuk72	769	21	Organization	Organization	NNP
cord-001859-d62iuk72	769	22	of	of	IN
cord-001859-d62iuk72	769	23	DNA	DNA	NNP
cord-001859-d62iuk72	769	24	Replication	Replication	NNP
cord-001859-d62iuk72	769	25	in	in	IN
cord-001859-d62iuk72	769	26	Mammalian	mammalian	JJ
cord-001859-d62iuk72	769	27	Cell	cell	NN
cord-001859-d62iuk72	769	28	Nuclei	Nuclei	NNPS
cord-001859-d62iuk72	769	29	:	:	:
cord-001859-d62iuk72	769	30	Spatially	spatially	RB
cord-001859-d62iuk72	769	31	and	and	CC
cord-001859-d62iuk72	769	32	Temporally	temporally	RB
cord-001859-d62iuk72	769	33	Defined	define	VBN
cord-001859-d62iuk72	769	34	Replication	Replication	NNP
cord-001859-d62iuk72	769	35	of	of	IN
cord-001859-d62iuk72	769	36	Chromosome	chromosome	NN
cord-001859-d62iuk72	769	37	-	-	HYPH
cord-001859-d62iuk72	769	38	Specific	specific	JJ
cord-001859-d62iuk72	769	39	Alpha	Alpha	NNP
cord-001859-d62iuk72	769	40	-	-	HYPH
cord-001859-d62iuk72	769	41	Satellite	satellite	NN
cord-001859-d62iuk72	769	42	DNA	dna	NN
cord-001859-d62iuk72	769	43	Sequences	sequence	NNS
cord-001859-d62iuk72	770	1	The	the	DT
cord-001859-d62iuk72	770	2	intra	intra	JJ
cord-001859-d62iuk72	770	3	-	-	JJ
cord-001859-d62iuk72	770	4	S	s	NN
cord-001859-d62iuk72	770	5	-	-	HYPH
cord-001859-d62iuk72	770	6	phase	phase	NN
cord-001859-d62iuk72	770	7	checkpoint	checkpoint	NN
cord-001859-d62iuk72	770	8	affects	affect	VBZ
cord-001859-d62iuk72	770	9	both	both	CC
cord-001859-d62iuk72	770	10	DNA	dna	NN
cord-001859-d62iuk72	770	11	replication	replication	NN
cord-001859-d62iuk72	770	12	initiation	initiation	NN
cord-001859-d62iuk72	770	13	and	and	CC
cord-001859-d62iuk72	770	14	elongation	elongation	NN
cord-001859-d62iuk72	770	15	:	:	:
cord-001859-d62iuk72	770	16	Single	single	JJ
cord-001859-d62iuk72	770	17	-	-	HYPH
cord-001859-d62iuk72	770	18	cell	cell	NN
cord-001859-d62iuk72	770	19	and	and	CC
cord-001859-d62iuk72	770	20	-DNA	-dna	NN
cord-001859-d62iuk72	770	21	fiber	fiber	NN
cord-001859-d62iuk72	770	22	analyses	analysis	NNS
cord-001859-d62iuk72	771	1	A	a	DT
cord-001859-d62iuk72	771	2	C	C	NNP
cord-001859-d62iuk72	771	3	-	-	HYPH
cord-001859-d62iuk72	771	4	Terminal	Terminal	NNP
cord-001859-d62iuk72	771	5	Signal	Signal	NNP
cord-001859-d62iuk72	771	6	Prevents	prevent	VBZ
cord-001859-d62iuk72	771	7	Secretion	secretion	NN
cord-001859-d62iuk72	771	8	of	of	IN
cord-001859-d62iuk72	771	9	Luminal	Luminal	NNP
cord-001859-d62iuk72	771	10	ER	ER	NNP
cord-001859-d62iuk72	771	11	Proteins	Proteins	NNP
cord-001859-d62iuk72	771	12	Functional	Functional	NNP
cord-001859-d62iuk72	771	13	Analysis	Analysis	NNP
cord-001859-d62iuk72	771	14	of	of	IN
cord-001859-d62iuk72	771	15	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	771	16	Inhibitors	Inhibitors	NNP
cord-001859-d62iuk72	771	17	Adenosine	Adenosine	NNP
cord-001859-d62iuk72	771	18	-	-	HYPH
cord-001859-d62iuk72	771	19	Derived	derive	VBN
cord-001859-d62iuk72	771	20	Inhibitors	Inhibitors	NNP
cord-001859-d62iuk72	771	21	of	of	IN
cord-001859-d62iuk72	771	22	78	78	CD
cord-001859-d62iuk72	771	23	kDa	kDa	NNPS
cord-001859-d62iuk72	771	24	Glucose	Glucose	NNP
cord-001859-d62iuk72	771	25	Regulated	Regulated	NNP
cord-001859-d62iuk72	771	26	Protein	Protein	NNP
cord-001859-d62iuk72	771	27	(	(	-LRB-
cord-001859-d62iuk72	771	28	Grp78	Grp78	NNP
cord-001859-d62iuk72	771	29	)	)	-RRB-
cord-001859-d62iuk72	771	30	ATPase	ATPase	NNP
cord-001859-d62iuk72	771	31	:	:	:
cord-001859-d62iuk72	772	1	Insights	insight	NNS
cord-001859-d62iuk72	772	2	into	into	IN
cord-001859-d62iuk72	772	3	Isoform	Isoform	NNP
cord-001859-d62iuk72	772	4	Selectivity	Selectivity	NNP
cord-001859-d62iuk72	773	1	A	a	DT
cord-001859-d62iuk72	773	2	novel	novel	NN
cord-001859-d62iuk72	773	3	,	,	,
cord-001859-d62iuk72	773	4	small	small	JJ
cord-001859-d62iuk72	773	5	molecule	molecule	NN
cord-001859-d62iuk72	773	6	inhibitor	inhibitor	NN
cord-001859-d62iuk72	773	7	of	of	IN
cord-001859-d62iuk72	773	8	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	773	9	/	/	SYM
cord-001859-d62iuk72	773	10	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	773	11	potentiates	potentiate	VBZ
cord-001859-d62iuk72	773	12	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	773	13	inhibitor	inhibitor	NN
cord-001859-d62iuk72	773	14	induced	induce	VBN
cord-001859-d62iuk72	773	15	apoptosis	apoptosis	NN
cord-001859-d62iuk72	773	16	in	in	IN
cord-001859-d62iuk72	773	17	HCT116	hct116	JJ
cord-001859-d62iuk72	773	18	colon	colon	NN
cord-001859-d62iuk72	773	19	carcinoma	carcinoma	NN
cord-001859-d62iuk72	773	20	cells	cell	NNS
cord-001859-d62iuk72	774	1	Influenza	influenza	NN
cord-001859-d62iuk72	774	2	virus	virus	NN
cord-001859-d62iuk72	774	3	infection	infection	NN
cord-001859-d62iuk72	774	4	causes	cause	VBZ
cord-001859-d62iuk72	774	5	specific	specific	JJ
cord-001859-d62iuk72	774	6	degradation	degradation	NN
cord-001859-d62iuk72	774	7	of	of	IN
cord-001859-d62iuk72	774	8	the	the	DT
cord-001859-d62iuk72	774	9	largest	large	JJS
cord-001859-d62iuk72	774	10	subunit	subunit	NN
cord-001859-d62iuk72	774	11	of	of	IN
cord-001859-d62iuk72	774	12	cellular	cellular	JJ
cord-001859-d62iuk72	774	13	RNA	RNA	NNP
cord-001859-d62iuk72	774	14	polymerase	polymerase	NN
cord-001859-d62iuk72	774	15	II	II	NNP
cord-001859-d62iuk72	774	16	Gene	Gene	NNP
cord-001859-d62iuk72	774	17	expression	expression	NN
cord-001859-d62iuk72	774	18	profiling	profiling	NN
cord-001859-d62iuk72	774	19	of	of	IN
cord-001859-d62iuk72	774	20	human	human	JJ
cord-001859-d62iuk72	774	21	colon	colon	NN
cord-001859-d62iuk72	774	22	cancer	cancer	NN
cord-001859-d62iuk72	774	23	cells	cell	NNS
cord-001859-d62iuk72	774	24	following	follow	VBG
cord-001859-d62iuk72	774	25	inhibition	inhibition	NN
cord-001859-d62iuk72	774	26	of	of	IN
cord-001859-d62iuk72	774	27	signal	signal	NN
cord-001859-d62iuk72	774	28	transduction	transduction	NN
cord-001859-d62iuk72	774	29	by	by	IN
cord-001859-d62iuk72	774	30	17-allylamino-17-demethoxygeldanamycin	17-allylamino-17-demethoxygeldanamycin	CD
cord-001859-d62iuk72	774	31	,	,	,
cord-001859-d62iuk72	774	32	an	an	DT
cord-001859-d62iuk72	774	33	inhibitor	inhibitor	NN
cord-001859-d62iuk72	774	34	of	of	IN
cord-001859-d62iuk72	774	35	hsp90	hsp90	JJ
cord-001859-d62iuk72	774	36	molecular	molecular	JJ
cord-001859-d62iuk72	774	37	chaperone	chaperone	NN
cord-001859-d62iuk72	774	38	Phase	phase	NN
cord-001859-d62iuk72	774	39	I	-PRON-	PRP
cord-001859-d62iuk72	774	40	Pharmacokinetic	Pharmacokinetic	NNP
cord-001859-d62iuk72	774	41	and	and	CC
cord-001859-d62iuk72	774	42	Pharmacodynamic	Pharmacodynamic	NNP
cord-001859-d62iuk72	774	43	Study	Study	NNP
cord-001859-d62iuk72	774	44	of	of	IN
cord-001859-d62iuk72	774	45	17-Allylamino	17-allylamino	CD
cord-001859-d62iuk72	774	46	,	,	,
cord-001859-d62iuk72	774	47	17-Demethoxygeldanamycin	17-demethoxygeldanamycin	CD
cord-001859-d62iuk72	774	48	in	in	IN
cord-001859-d62iuk72	774	49	Patients	patient	NNS
cord-001859-d62iuk72	774	50	With	with	IN
cord-001859-d62iuk72	774	51	Advanced	advanced	JJ
cord-001859-d62iuk72	774	52	Malignancies	Malignancies	NNPS
cord-001859-d62iuk72	774	53	Herpes	Herpes	NNP
cord-001859-d62iuk72	774	54	simplex	simplex	NN
cord-001859-d62iuk72	774	55	virus	virus	NN
cord-001859-d62iuk72	774	56	type	type	NN
cord-001859-d62iuk72	774	57	1	1	CD
cord-001859-d62iuk72	774	58	DNA	dna	NN
cord-001859-d62iuk72	774	59	polymerase	polymerase	NN
cord-001859-d62iuk72	774	60	requires	require	VBZ
cord-001859-d62iuk72	774	61	the	the	DT
cord-001859-d62iuk72	774	62	mammalian	mammalian	JJ
cord-001859-d62iuk72	774	63	chaperone	chaperone	NN
cord-001859-d62iuk72	774	64	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	774	65	for	for	IN
cord-001859-d62iuk72	774	66	proper	proper	JJ
cord-001859-d62iuk72	774	67	localization	localization	NN
cord-001859-d62iuk72	774	68	to	to	IN
cord-001859-d62iuk72	774	69	the	the	DT
cord-001859-d62iuk72	774	70	nucleus	nucleus	NN
cord-001859-d62iuk72	775	1	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	775	2	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	775	3	reduce	reduce	VBP
cord-001859-d62iuk72	775	4	influenza	influenza	NN
cord-001859-d62iuk72	775	5	virus	virus	NN
cord-001859-d62iuk72	775	6	replication	replication	NN
cord-001859-d62iuk72	775	7	in	in	IN
cord-001859-d62iuk72	775	8	cell	cell	NN
cord-001859-d62iuk72	775	9	culture	culture	NN
cord-001859-d62iuk72	775	10	Evolutionary	evolutionary	JJ
cord-001859-d62iuk72	775	11	constraints	constraint	NNS
cord-001859-d62iuk72	775	12	on	on	IN
cord-001859-d62iuk72	775	13	chaperone	chaperone	NN
cord-001859-d62iuk72	775	14	-	-	HYPH
cord-001859-d62iuk72	775	15	mediated	mediate	VBN
cord-001859-d62iuk72	775	16	folding	folding	NN
cord-001859-d62iuk72	775	17	provide	provide	VBP
cord-001859-d62iuk72	775	18	an	an	DT
cord-001859-d62iuk72	775	19	antiviral	antiviral	JJ
cord-001859-d62iuk72	775	20	approach	approach	NN
cord-001859-d62iuk72	775	21	refractory	refractory	JJ
cord-001859-d62iuk72	775	22	to	to	IN
cord-001859-d62iuk72	775	23	development	development	NN
cord-001859-d62iuk72	775	24	of	of	IN
cord-001859-d62iuk72	775	25	drug	drug	NN
cord-001859-d62iuk72	775	26	resistance	resistance	NN
cord-001859-d62iuk72	776	1	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	776	2	Inhibitors	Inhibitors	NNP
cord-001859-d62iuk72	777	1	Exhibit	Exhibit	NNP
cord-001859-d62iuk72	777	2	Resistance	Resistance	NNP
cord-001859-d62iuk72	777	3	-	-	HYPH
cord-001859-d62iuk72	777	4	Free	Free	NNP
cord-001859-d62iuk72	777	5	Antiviral	Antiviral	NNP
cord-001859-d62iuk72	777	6	Activity	Activity	NNP
cord-001859-d62iuk72	777	7	against	against	IN
cord-001859-d62iuk72	777	8	Respiratory	respiratory	JJ
cord-001859-d62iuk72	777	9	Syncytial	Syncytial	NNP
cord-001859-d62iuk72	777	10	Virus	Virus	NNP
cord-001859-d62iuk72	777	11	Antiviral	antiviral	JJ
cord-001859-d62iuk72	777	12	activity	activity	NN
cord-001859-d62iuk72	777	13	and	and	CC
cord-001859-d62iuk72	777	14	RNA	rna	NN
cord-001859-d62iuk72	777	15	polymerase	polymerase	NN
cord-001859-d62iuk72	777	16	degradation	degradation	NN
cord-001859-d62iuk72	777	17	following	follow	VBG
cord-001859-d62iuk72	777	18	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	777	19	inhibition	inhibition	NN
cord-001859-d62iuk72	777	20	in	in	IN
cord-001859-d62iuk72	777	21	a	a	DT
cord-001859-d62iuk72	777	22	range	range	NN
cord-001859-d62iuk72	777	23	of	of	IN
cord-001859-d62iuk72	777	24	negative	negative	JJ
cord-001859-d62iuk72	777	25	strand	strand	NN
cord-001859-d62iuk72	777	26	viruses	virus	NNS
cord-001859-d62iuk72	777	27	Update	update	VBP
cord-001859-d62iuk72	777	28	on	on	RP
cord-001859-d62iuk72	777	29	in	in	IN
cord-001859-d62iuk72	777	30	vitro	vitro	FW
cord-001859-d62iuk72	777	31	cytotoxicity	cytotoxicity	NN
cord-001859-d62iuk72	777	32	assays	assay	NNS
cord-001859-d62iuk72	777	33	for	for	IN
cord-001859-d62iuk72	777	34	drug	drug	NN
cord-001859-d62iuk72	777	35	development	development	NN
cord-001859-d62iuk72	777	36	VER-155008	VER-155008	NNP
cord-001859-d62iuk72	777	37	,	,	,
cord-001859-d62iuk72	777	38	a	a	DT
cord-001859-d62iuk72	777	39	small	small	JJ
cord-001859-d62iuk72	777	40	molecule	molecule	NN
cord-001859-d62iuk72	777	41	inhibitor	inhibitor	NN
cord-001859-d62iuk72	777	42	of	of	IN
cord-001859-d62iuk72	777	43	HSP70	HSP70	NNP
cord-001859-d62iuk72	777	44	with	with	IN
cord-001859-d62iuk72	777	45	potent	potent	JJ
cord-001859-d62iuk72	777	46	anti	anti	JJ
cord-001859-d62iuk72	777	47	-	-	JJ
cord-001859-d62iuk72	777	48	cancer	cancer	JJ
cord-001859-d62iuk72	777	49	activity	activity	NN
cord-001859-d62iuk72	777	50	on	on	IN
cord-001859-d62iuk72	777	51	lung	lung	NN
cord-001859-d62iuk72	777	52	cancer	cancer	NN
cord-001859-d62iuk72	777	53	cell	cell	NN
cord-001859-d62iuk72	777	54	lines	line	NNS
cord-001859-d62iuk72	777	55	In	in	IN
cord-001859-d62iuk72	777	56	vivo	vivo	NNP
cord-001859-d62iuk72	777	57	newly	newly	RB
cord-001859-d62iuk72	777	58	translated	translate	VBN
cord-001859-d62iuk72	777	59	polypeptides	polypeptide	NNS
cord-001859-d62iuk72	777	60	are	be	VBP
cord-001859-d62iuk72	777	61	sequestered	sequester	VBN
cord-001859-d62iuk72	777	62	in	in	IN
cord-001859-d62iuk72	777	63	a	a	DT
cord-001859-d62iuk72	777	64	protected	protect	VBN
cord-001859-d62iuk72	777	65	folding	folding	NN
cord-001859-d62iuk72	777	66	environment	environment	NN
cord-001859-d62iuk72	777	67	Auto	auto	NN
cord-001859-d62iuk72	777	68	-	-	HYPH
cord-001859-d62iuk72	777	69	activation	activation	NN
cord-001859-d62iuk72	777	70	of	of	IN
cord-001859-d62iuk72	777	71	the	the	DT
cord-001859-d62iuk72	777	72	rta	rta	NNP
cord-001859-d62iuk72	777	73	gene	gene	NN
cord-001859-d62iuk72	777	74	of	of	IN
cord-001859-d62iuk72	777	75	human	human	JJ
cord-001859-d62iuk72	777	76	herpesvirus-8	herpesvirus-8	NNP
cord-001859-d62iuk72	777	77	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	78	's	's	POS
cord-001859-d62iuk72	777	79	sarcomaassociated	sarcomaassociate	VBN
cord-001859-d62iuk72	777	80	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	81	Transcription	Transcription	NNP
cord-001859-d62iuk72	777	82	activation	activation	NN
cord-001859-d62iuk72	777	83	of	of	IN
cord-001859-d62iuk72	777	84	polyadenylated	polyadenylated	JJ
cord-001859-d62iuk72	777	85	nuclear	nuclear	NNP
cord-001859-d62iuk72	777	86	RNA	RNA	NNP
cord-001859-d62iuk72	777	87	by	by	IN
cord-001859-d62iuk72	777	88	Rta	Rta	NNP
cord-001859-d62iuk72	777	89	in	in	IN
cord-001859-d62iuk72	777	90	human	human	JJ
cord-001859-d62iuk72	777	91	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	92	8	8	CD
cord-001859-d62iuk72	777	93	/	/	SYM
cord-001859-d62iuk72	777	94	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	95	's	's	POS
cord-001859-d62iuk72	777	96	sarcoma	sarcoma	NN
cord-001859-d62iuk72	777	97	-	-	HYPH
cord-001859-d62iuk72	777	98	associated	associate	VBN
cord-001859-d62iuk72	777	99	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	100	Identification	identification	NN
cord-001859-d62iuk72	777	101	of	of	IN
cord-001859-d62iuk72	777	102	Direct	Direct	NNP
cord-001859-d62iuk72	777	103	Transcriptional	Transcriptional	NNP
cord-001859-d62iuk72	777	104	Targets	Targets	NNPS
cord-001859-d62iuk72	777	105	of	of	IN
cord-001859-d62iuk72	777	106	the	the	DT
cord-001859-d62iuk72	777	107	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	108	's	's	POS
cord-001859-d62iuk72	777	109	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	777	110	-	-	HYPH
cord-001859-d62iuk72	777	111	Associated	Associated	NNP
cord-001859-d62iuk72	777	112	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	777	113	Rta	Rta	NNP
cord-001859-d62iuk72	777	114	Lytic	Lytic	NNP
cord-001859-d62iuk72	777	115	Switch	Switch	NNP
cord-001859-d62iuk72	777	116	Protein	Protein	NNP
cord-001859-d62iuk72	777	117	by	by	IN
cord-001859-d62iuk72	777	118	Conditional	Conditional	NNP
cord-001859-d62iuk72	777	119	Nuclear	Nuclear	NNP
cord-001859-d62iuk72	777	120	Localization	Localization	NNP
cord-001859-d62iuk72	777	121	Comparative	Comparative	NNP
cord-001859-d62iuk72	777	122	study	study	NN
cord-001859-d62iuk72	777	123	of	of	IN
cord-001859-d62iuk72	777	124	regulation	regulation	NN
cord-001859-d62iuk72	777	125	of	of	IN
cord-001859-d62iuk72	777	126	RTA	RTA	NNP
cord-001859-d62iuk72	777	127	-	-	HYPH
cord-001859-d62iuk72	777	128	responsive	responsive	JJ
cord-001859-d62iuk72	777	129	genes	gene	NNS
cord-001859-d62iuk72	777	130	in	in	IN
cord-001859-d62iuk72	777	131	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	132	's	's	POS
cord-001859-d62iuk72	777	133	sarcoma	sarcoma	NN
cord-001859-d62iuk72	777	134	-	-	HYPH
cord-001859-d62iuk72	777	135	associated	associate	VBN
cord-001859-d62iuk72	777	136	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	137	/	/	SYM
cord-001859-d62iuk72	777	138	human	human	JJ
cord-001859-d62iuk72	777	139	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	140	8	8	CD
cord-001859-d62iuk72	777	141	A	a	DT
cord-001859-d62iuk72	777	142	comprehensive	comprehensive	JJ
cord-001859-d62iuk72	777	143	analysis	analysis	NN
cord-001859-d62iuk72	777	144	of	of	IN
cord-001859-d62iuk72	777	145	recruitment	recruitment	NN
cord-001859-d62iuk72	777	146	and	and	CC
cord-001859-d62iuk72	777	147	transactivation	transactivation	NN
cord-001859-d62iuk72	777	148	potential	potential	NN
cord-001859-d62iuk72	777	149	of	of	IN
cord-001859-d62iuk72	777	150	K	K	NNP
cord-001859-d62iuk72	777	151	-	-	HYPH
cord-001859-d62iuk72	777	152	Rta	Rta	NNP
cord-001859-d62iuk72	777	153	and	and	CC
cord-001859-d62iuk72	777	154	K	K	NNP
cord-001859-d62iuk72	777	155	-	-	HYPH
cord-001859-d62iuk72	777	156	bZIP	bzip	XX
cord-001859-d62iuk72	777	157	during	during	IN
cord-001859-d62iuk72	777	158	reactivation	reactivation	NN
cord-001859-d62iuk72	777	159	of	of	IN
cord-001859-d62iuk72	777	160	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	161	's	's	POS
cord-001859-d62iuk72	777	162	sarcoma	sarcoma	NN
cord-001859-d62iuk72	777	163	-	-	HYPH
cord-001859-d62iuk72	777	164	associated	associate	VBN
cord-001859-d62iuk72	777	165	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	777	166	A	a	DT
cord-001859-d62iuk72	777	167	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	168	's	's	POS
cord-001859-d62iuk72	777	169	sarcoma	sarcoma	NN
cord-001859-d62iuk72	777	170	virus	virus	NN
cord-001859-d62iuk72	777	171	RNA	rna	NN
cord-001859-d62iuk72	777	172	element	element	NN
cord-001859-d62iuk72	777	173	that	that	WDT
cord-001859-d62iuk72	777	174	increases	increase	VBZ
cord-001859-d62iuk72	777	175	the	the	DT
cord-001859-d62iuk72	777	176	nuclear	nuclear	JJ
cord-001859-d62iuk72	777	177	abundance	abundance	NN
cord-001859-d62iuk72	777	178	of	of	IN
cord-001859-d62iuk72	777	179	intronless	intronless	NN
cord-001859-d62iuk72	777	180	transcripts	transcript	NNS
cord-001859-d62iuk72	777	181	Stability	stability	NN
cord-001859-d62iuk72	777	182	of	of	IN
cord-001859-d62iuk72	777	183	a	a	DT
cord-001859-d62iuk72	777	184	Long	long	JJ
cord-001859-d62iuk72	777	185	Noncoding	Noncoding	NNP
cord-001859-d62iuk72	777	186	Viral	Viral	NNP
cord-001859-d62iuk72	777	187	RNA	RNA	NNP
cord-001859-d62iuk72	777	188	Depends	depend	VBZ
cord-001859-d62iuk72	777	189	on	on	IN
cord-001859-d62iuk72	777	190	a	a	DT
cord-001859-d62iuk72	777	191	9-nt	9-nt	CD
cord-001859-d62iuk72	777	192	Core	Core	NNP
cord-001859-d62iuk72	777	193	Element	Element	NNP
cord-001859-d62iuk72	777	194	at	at	IN
cord-001859-d62iuk72	777	195	the	the	DT
cord-001859-d62iuk72	777	196	RNA	RNA	NNP
cord-001859-d62iuk72	777	197	5	5	CD
cord-001859-d62iuk72	777	198	'	'	``
cord-001859-d62iuk72	777	199	End	end	NN
cord-001859-d62iuk72	777	200	to	to	TO
cord-001859-d62iuk72	777	201	Interact	interact	VB
cord-001859-d62iuk72	777	202	with	with	IN
cord-001859-d62iuk72	777	203	Viral	Viral	NNP
cord-001859-d62iuk72	777	204	ORF57	ORF57	NNP
cord-001859-d62iuk72	777	205	and	and	CC
cord-001859-d62iuk72	777	206	Cellular	Cellular	NNP
cord-001859-d62iuk72	777	207	PABPC1	pabpc1	NN
cord-001859-d62iuk72	777	208	Cell	cell	NN
cord-001859-d62iuk72	777	209	Cycle	cycle	NN
cord-001859-d62iuk72	777	210	Arrest	arrest	NN
cord-001859-d62iuk72	777	211	by	by	IN
cord-001859-d62iuk72	777	212	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	777	213	's	's	POS
cord-001859-d62iuk72	777	214	Sarcoma	Sarcoma	NNP
cord-001859-d62iuk72	777	215	-	-	HYPH
cord-001859-d62iuk72	777	216	Associated	Associated	NNP
cord-001859-d62iuk72	777	217	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	777	218	Replication	Replication	NNP
cord-001859-d62iuk72	777	219	-	-	HYPH
cord-001859-d62iuk72	777	220	Associated	Associated	NNP
cord-001859-d62iuk72	777	221	Protein	Protein	NNP
cord-001859-d62iuk72	778	1	Is	be	VBZ
cord-001859-d62iuk72	778	2	Mediated	mediate	VBN
cord-001859-d62iuk72	778	3	at	at	IN
cord-001859-d62iuk72	778	4	both	both	CC
cord-001859-d62iuk72	778	5	the	the	DT
cord-001859-d62iuk72	778	6	Transcriptional	Transcriptional	NNP
cord-001859-d62iuk72	778	7	and	and	CC
cord-001859-d62iuk72	778	8	Posttranslational	Posttranslational	NNP
cord-001859-d62iuk72	778	9	Levels	Levels	NNP
cord-001859-d62iuk72	778	10	by	by	IN
cord-001859-d62iuk72	778	11	Binding	bind	VBG
cord-001859-d62iuk72	778	12	to	to	IN
cord-001859-d62iuk72	778	13	CCAAT/	CCAAT/	NNP
cord-001859-d62iuk72	779	1	Enhancer	Enhancer	NNP
cord-001859-d62iuk72	779	2	-	-	HYPH
cord-001859-d62iuk72	779	3	Binding	Binding	NNP
cord-001859-d62iuk72	779	4	A	a	NN
cord-001859-d62iuk72	780	1	Viral	Viral	NNP
cord-001859-d62iuk72	780	2	Nuclear	Nuclear	NNP
cord-001859-d62iuk72	780	3	Noncoding	Noncoding	NNP
cord-001859-d62iuk72	780	4	RNA	RNA	NNP
cord-001859-d62iuk72	780	5	Binds	bind	VBZ
cord-001859-d62iuk72	780	6	Relocalized	Relocalized	NNP
cord-001859-d62iuk72	780	7	Poly(A	Poly(A	NNP
cord-001859-d62iuk72	780	8	)	)	-RRB-
cord-001859-d62iuk72	781	1	Binding	Binding	NNP
cord-001859-d62iuk72	781	2	Protein	Protein	NNP
cord-001859-d62iuk72	781	3	and	and	CC
cord-001859-d62iuk72	781	4	Is	be	VBZ
cord-001859-d62iuk72	781	5	Required	require	VBN
cord-001859-d62iuk72	781	6	for	for	IN
cord-001859-d62iuk72	781	7	Late	Late	NNP
cord-001859-d62iuk72	781	8	KSHV	KSHV	NNP
cord-001859-d62iuk72	782	1	Gene	Gene	NNP
cord-001859-d62iuk72	782	2	Expression	Expression	NNP
cord-001859-d62iuk72	782	3	Nuclear	Nuclear	NNP
cord-001859-d62iuk72	782	4	sequestration	sequestration	NN
cord-001859-d62iuk72	782	5	of	of	IN
cord-001859-d62iuk72	782	6	cellular	cellular	JJ
cord-001859-d62iuk72	782	7	chaperone	chaperone	NN
cord-001859-d62iuk72	782	8	and	and	CC
cord-001859-d62iuk72	782	9	proteasomal	proteasomal	NN
cord-001859-d62iuk72	782	10	machinery	machinery	NN
cord-001859-d62iuk72	782	11	during	during	IN
cord-001859-d62iuk72	782	12	herpes	herpes	NNP
cord-001859-d62iuk72	782	13	simplex	simplex	NNP
cord-001859-d62iuk72	782	14	virus	virus	NN
cord-001859-d62iuk72	782	15	type	type	NN
cord-001859-d62iuk72	782	16	1	1	CD
cord-001859-d62iuk72	782	17	infection	infection	NN
cord-001859-d62iuk72	782	18	Hsc70	Hsc70	NNP
cord-001859-d62iuk72	782	19	Focus	Focus	NNP
cord-001859-d62iuk72	782	20	Formation	Formation	NNP
cord-001859-d62iuk72	782	21	at	at	IN
cord-001859-d62iuk72	782	22	the	the	DT
cord-001859-d62iuk72	782	23	Periphery	Periphery	NNP
cord-001859-d62iuk72	782	24	of	of	IN
cord-001859-d62iuk72	782	25	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	782	26	Transcription	Transcription	NNP
cord-001859-d62iuk72	782	27	Sites	Sites	NNPS
cord-001859-d62iuk72	782	28	Requires	require	VBZ
cord-001859-d62iuk72	782	29	ICP27	ICP27	NNP
cord-001859-d62iuk72	782	30	Virus	virus	NN
cord-001859-d62iuk72	782	31	-	-	HYPH
cord-001859-d62iuk72	782	32	Induced	induce	VBN
cord-001859-d62iuk72	782	33	Chaperone	Chaperone	NNP
cord-001859-d62iuk72	782	34	-	-	HYPH
cord-001859-d62iuk72	782	35	Enriched	Enriched	NNP
cord-001859-d62iuk72	782	36	(	(	-LRB-
cord-001859-d62iuk72	782	37	VICE	vice	NN
cord-001859-d62iuk72	782	38	)	)	-RRB-
cord-001859-d62iuk72	782	39	Domains	domain	NNS
cord-001859-d62iuk72	782	40	Function	Function	NNP
cord-001859-d62iuk72	782	41	as	as	IN
cord-001859-d62iuk72	782	42	Nuclear	Nuclear	NNP
cord-001859-d62iuk72	782	43	Protein	Protein	NNP
cord-001859-d62iuk72	782	44	Quality	Quality	NNP
cord-001859-d62iuk72	782	45	Control	Control	NNP
cord-001859-d62iuk72	782	46	Centers	Centers	NNPS
cord-001859-d62iuk72	782	47	during	during	IN
cord-001859-d62iuk72	782	48	HSV-1	HSV-1	NNP
cord-001859-d62iuk72	782	49	Infection	Infection	NNP
cord-001859-d62iuk72	782	50	Function	Function	NNP
cord-001859-d62iuk72	782	51	of	of	IN
cord-001859-d62iuk72	782	52	Dnaj	Dnaj	NNP
cord-001859-d62iuk72	782	53	and	and	CC
cord-001859-d62iuk72	782	54	Dnak	Dnak	NNP
cord-001859-d62iuk72	782	55	as	as	IN
cord-001859-d62iuk72	782	56	Chaperones	Chaperones	NNPS
cord-001859-d62iuk72	782	57	in	in	IN
cord-001859-d62iuk72	782	58	Origin	Origin	NNP
cord-001859-d62iuk72	782	59	-	-	HYPH
cord-001859-d62iuk72	782	60	Specific	specific	JJ
cord-001859-d62iuk72	782	61	DNA	dna	NN
cord-001859-d62iuk72	782	62	-	-	HYPH
cord-001859-d62iuk72	782	63	Binding	binding	NN
cord-001859-d62iuk72	782	64	by	by	IN
cord-001859-d62iuk72	783	1	Repa	Repa	NNP
cord-001859-d62iuk72	783	2	Three	three	CD
cord-001859-d62iuk72	784	1	Escherichia	escherichia	NN
cord-001859-d62iuk72	784	2	coli	coli	NNS
cord-001859-d62iuk72	784	3	heat	heat	NN
cord-001859-d62iuk72	784	4	shock	shock	NN
cord-001859-d62iuk72	784	5	proteins	protein	NNS
cord-001859-d62iuk72	784	6	are	be	VBP
cord-001859-d62iuk72	784	7	required	require	VBN
cord-001859-d62iuk72	784	8	for	for	IN
cord-001859-d62iuk72	784	9	P1	P1	NNP
cord-001859-d62iuk72	784	10	plasmid	plasmid	NN
cord-001859-d62iuk72	784	11	DNA	dna	NN
cord-001859-d62iuk72	784	12	replication	replication	NN
cord-001859-d62iuk72	784	13	:	:	:
cord-001859-d62iuk72	784	14	formation	formation	NN
cord-001859-d62iuk72	784	15	of	of	IN
cord-001859-d62iuk72	784	16	an	an	DT
cord-001859-d62iuk72	784	17	active	active	JJ
cord-001859-d62iuk72	784	18	complex	complex	NN
cord-001859-d62iuk72	784	19	between	between	IN
cord-001859-d62iuk72	784	20	E.	E.	NNP
cord-001859-d62iuk72	784	21	coli	coli	NNS
cord-001859-d62iuk72	784	22	DnaJ	DnaJ	NNP
cord-001859-d62iuk72	784	23	protein	protein	NN
cord-001859-d62iuk72	784	24	and	and	CC
cord-001859-d62iuk72	784	25	the	the	DT
cord-001859-d62iuk72	784	26	P1	P1	NNP
cord-001859-d62iuk72	784	27	initiator	initiator	NN
cord-001859-d62iuk72	784	28	protein	protein	NN
cord-001859-d62iuk72	784	29	Similarities	similarity	NNS
cord-001859-d62iuk72	784	30	between	between	IN
cord-001859-d62iuk72	784	31	the	the	DT
cord-001859-d62iuk72	784	32	DNA	dna	NN
cord-001859-d62iuk72	784	33	replication	replication	NN
cord-001859-d62iuk72	784	34	initiators	initiator	NNS
cord-001859-d62iuk72	784	35	of	of	IN
cord-001859-d62iuk72	784	36	Gram	gram	NN
cord-001859-d62iuk72	784	37	-	-	HYPH
cord-001859-d62iuk72	784	38	negative	negative	JJ
cord-001859-d62iuk72	784	39	bacteria	bacteria	NNS
cord-001859-d62iuk72	784	40	plasmids	plasmid	NNS
cord-001859-d62iuk72	784	41	(	(	-LRB-
cord-001859-d62iuk72	784	42	RepA	RepA	NNP
cord-001859-d62iuk72	784	43	)	)	-RRB-
cord-001859-d62iuk72	784	44	and	and	CC
cord-001859-d62iuk72	784	45	eukaryotes	eukaryote	NNS
cord-001859-d62iuk72	784	46	(	(	-LRB-
cord-001859-d62iuk72	785	1	Orc4p)/archaea	Orc4p)/archaea	NNP
cord-001859-d62iuk72	785	2	(	(	-LRB-
cord-001859-d62iuk72	785	3	Cdc6p	Cdc6p	NNP
cord-001859-d62iuk72	785	4	)	)	-RRB-
cord-001859-d62iuk72	785	5	Human	Human	NNP
cord-001859-d62iuk72	785	6	Hsp70	Hsp70	NNP
cord-001859-d62iuk72	785	7	and	and	CC
cord-001859-d62iuk72	785	8	Hsp40	Hsp40	NNP
cord-001859-d62iuk72	785	9	chaperone	chaperone	NN
cord-001859-d62iuk72	785	10	proteins	protein	NNS
cord-001859-d62iuk72	785	11	facilitate	facilitate	VBP
cord-001859-d62iuk72	785	12	human	human	JJ
cord-001859-d62iuk72	785	13	papillomavirus-11	papillomavirus-11	CD
cord-001859-d62iuk72	785	14	E1	e1	NN
cord-001859-d62iuk72	785	15	protein	protein	NN
cord-001859-d62iuk72	785	16	binding	bind	VBG
cord-001859-d62iuk72	785	17	to	to	IN
cord-001859-d62iuk72	785	18	the	the	DT
cord-001859-d62iuk72	785	19	origin	origin	NN
cord-001859-d62iuk72	785	20	and	and	CC
cord-001859-d62iuk72	785	21	stimulate	stimulate	VB
cord-001859-d62iuk72	785	22	cell	cell	NN
cord-001859-d62iuk72	785	23	-	-	HYPH
cord-001859-d62iuk72	785	24	free	free	JJ
cord-001859-d62iuk72	785	25	DNA	dna	NN
cord-001859-d62iuk72	785	26	replication	replication	NN
cord-001859-d62iuk72	785	27	Chaperone	chaperone	NN
cord-001859-d62iuk72	785	28	proteins	protein	NNS
cord-001859-d62iuk72	785	29	abrogate	abrogate	VBP
cord-001859-d62iuk72	785	30	inhibition	inhibition	NN
cord-001859-d62iuk72	785	31	of	of	IN
cord-001859-d62iuk72	785	32	the	the	DT
cord-001859-d62iuk72	785	33	human	human	JJ
cord-001859-d62iuk72	785	34	papillomavirus	papillomavirus	NN
cord-001859-d62iuk72	785	35	(	(	-LRB-
cord-001859-d62iuk72	785	36	HPV	HPV	NNP
cord-001859-d62iuk72	785	37	)	)	-RRB-
cord-001859-d62iuk72	785	38	E1	e1	NN
cord-001859-d62iuk72	785	39	replicative	replicative	JJ
cord-001859-d62iuk72	785	40	helicase	helicase	NN
cord-001859-d62iuk72	785	41	by	by	IN
cord-001859-d62iuk72	785	42	the	the	DT
cord-001859-d62iuk72	785	43	HPV	HPV	NNP
cord-001859-d62iuk72	785	44	E2	E2	NNP
cord-001859-d62iuk72	785	45	protein	protein	NN
cord-001859-d62iuk72	785	46	Activation	activation	NN
cord-001859-d62iuk72	785	47	of	of	IN
cord-001859-d62iuk72	785	48	the	the	DT
cord-001859-d62iuk72	785	49	herpes	herpes	NNP
cord-001859-d62iuk72	785	50	simplex	simplex	NN
cord-001859-d62iuk72	785	51	virus	virus	NN
cord-001859-d62iuk72	785	52	type-1	type-1	NNP
cord-001859-d62iuk72	785	53	origin	origin	NN
cord-001859-d62iuk72	785	54	-	-	HYPH
cord-001859-d62iuk72	785	55	binding	bind	VBG
cord-001859-d62iuk72	785	56	protein	protein	NN
cord-001859-d62iuk72	785	57	(	(	-LRB-
cord-001859-d62iuk72	785	58	UL9	UL9	NNP
cord-001859-d62iuk72	785	59	)	)	-RRB-
cord-001859-d62iuk72	785	60	by	by	IN
cord-001859-d62iuk72	785	61	heat	heat	NN
cord-001859-d62iuk72	785	62	shock	shock	NN
cord-001859-d62iuk72	785	63	proteins	protein	NNS
cord-001859-d62iuk72	785	64	Heat	Heat	NNP
cord-001859-d62iuk72	785	65	Shock	Shock	NNP
cord-001859-d62iuk72	785	66	Protein	Protein	NNP
cord-001859-d62iuk72	785	67	-	-	HYPH
cord-001859-d62iuk72	785	68	Mediated	mediate	VBN
cord-001859-d62iuk72	785	69	Disassembly	Disassembly	NNP
cord-001859-d62iuk72	785	70	of	of	IN
cord-001859-d62iuk72	785	71	Nucleoprotein	Nucleoprotein	NNP
cord-001859-d62iuk72	785	72	Structures	structure	NNS
cord-001859-d62iuk72	786	1	Is	be	VBZ
cord-001859-d62iuk72	786	2	Required	require	VBN
cord-001859-d62iuk72	786	3	for	for	IN
cord-001859-d62iuk72	786	4	the	the	DT
cord-001859-d62iuk72	786	5	Initiation	Initiation	NNP
cord-001859-d62iuk72	786	6	of	of	IN
cord-001859-d62iuk72	786	7	Bacteriophage	Bacteriophage	NNP
cord-001859-d62iuk72	786	8	Lambda	Lambda	NNP
cord-001859-d62iuk72	786	9	DNA	DNA	NNP
cord-001859-d62iuk72	786	10	Replication	Replication	NNP
cord-001859-d62iuk72	786	11	Ordered	order	VBD
cord-001859-d62iuk72	786	12	Assembly	Assembly	NNP
cord-001859-d62iuk72	786	13	of	of	IN
cord-001859-d62iuk72	786	14	Nucleoprotein	Nucleoprotein	NNP
cord-001859-d62iuk72	786	15	Structures	Structures	NNPS
cord-001859-d62iuk72	786	16	at	at	IN
cord-001859-d62iuk72	786	17	the	the	DT
cord-001859-d62iuk72	786	18	Bacteriophage	Bacteriophage	NNP
cord-001859-d62iuk72	786	19	Lambda	Lambda	NNP
cord-001859-d62iuk72	786	20	Replication	Replication	NNP
cord-001859-d62iuk72	786	21	Origin	Origin	NNP
cord-001859-d62iuk72	786	22	during	during	IN
cord-001859-d62iuk72	786	23	the	the	DT
cord-001859-d62iuk72	786	24	Initiation	Initiation	NNP
cord-001859-d62iuk72	786	25	of	of	IN
cord-001859-d62iuk72	786	26	DNA	DNA	NNP
cord-001859-d62iuk72	786	27	Replication	Replication	NNP
cord-001859-d62iuk72	786	28	Host	Host	NNP
cord-001859-d62iuk72	786	29	and	and	CC
cord-001859-d62iuk72	786	30	viral	viral	JJ
cord-001859-d62iuk72	786	31	proteins	protein	NNS
cord-001859-d62iuk72	786	32	in	in	IN
cord-001859-d62iuk72	786	33	the	the	DT
cord-001859-d62iuk72	786	34	virion	virion	NN
cord-001859-d62iuk72	786	35	of	of	IN
cord-001859-d62iuk72	786	36	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	786	37	's	's	POS
cord-001859-d62iuk72	786	38	sarcoma	sarcoma	NN
cord-001859-d62iuk72	786	39	-	-	HYPH
cord-001859-d62iuk72	786	40	associated	associate	VBN
cord-001859-d62iuk72	786	41	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	786	42	Virion	virion	NN
cord-001859-d62iuk72	786	43	proteins	protein	NNS
cord-001859-d62iuk72	786	44	of	of	IN
cord-001859-d62iuk72	786	45	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	786	46	's	's	POS
cord-001859-d62iuk72	786	47	sarcoma	sarcoma	NN
cord-001859-d62iuk72	786	48	-	-	HYPH
cord-001859-d62iuk72	786	49	associated	associate	VBN
cord-001859-d62iuk72	786	50	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	786	51	The	the	DT
cord-001859-d62iuk72	786	52	HSP70	HSP70	NNP
cord-001859-d62iuk72	786	53	family	family	NN
cord-001859-d62iuk72	786	54	and	and	CC
cord-001859-d62iuk72	786	55	cancer	cancer	NN
cord-001859-d62iuk72	786	56	Peptides	peptide	NNS
cord-001859-d62iuk72	786	57	and	and	CC
cord-001859-d62iuk72	786	58	Aptamers	Aptamers	NNPS
cord-001859-d62iuk72	787	1	Targeting	target	VBG
cord-001859-d62iuk72	787	2	HSP70	HSP70	NNP
cord-001859-d62iuk72	787	3	:	:	:
cord-001859-d62iuk72	788	1	A	a	DT
cord-001859-d62iuk72	788	2	Novel	Novel	NNP
cord-001859-d62iuk72	788	3	Approach	Approach	NNP
cord-001859-d62iuk72	788	4	for	for	IN
cord-001859-d62iuk72	788	5	Anticancer	Anticancer	NNP
cord-001859-d62iuk72	788	6	Chemotherapy	Chemotherapy	NNP
cord-001859-d62iuk72	788	7	Cysteine	Cysteine	NNP
cord-001859-d62iuk72	788	8	Reactivity	Reactivity	NNP
cord-001859-d62iuk72	788	9	Distinguishes	distinguish	VBZ
cord-001859-d62iuk72	788	10	Redox	Redox	NNP
cord-001859-d62iuk72	788	11	Sensing	Sensing	NNP
cord-001859-d62iuk72	788	12	by	by	IN
cord-001859-d62iuk72	788	13	the	the	DT
cord-001859-d62iuk72	788	14	Heat	Heat	NNP
cord-001859-d62iuk72	788	15	-	-	HYPH
cord-001859-d62iuk72	788	16	Inducible	Inducible	NNP
cord-001859-d62iuk72	788	17	and	and	CC
cord-001859-d62iuk72	788	18	Constitutive	Constitutive	NNP
cord-001859-d62iuk72	788	19	Forms	Forms	NNPS
cord-001859-d62iuk72	788	20	of	of	IN
cord-001859-d62iuk72	788	21	Heat	Heat	NNP
cord-001859-d62iuk72	788	22	Shock	Shock	NNP
cord-001859-d62iuk72	788	23	Protein	Protein	NNP
cord-001859-d62iuk72	788	24	70	70	CD
cord-001859-d62iuk72	788	25	A	a	DT
cord-001859-d62iuk72	788	26	high	high	JJ
cord-001859-d62iuk72	788	27	-	-	HYPH
cord-001859-d62iuk72	788	28	affinity	affinity	NN
cord-001859-d62iuk72	788	29	conformation	conformation	NN
cord-001859-d62iuk72	788	30	of	of	IN
cord-001859-d62iuk72	788	31	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	788	32	confers	confer	VBZ
cord-001859-d62iuk72	788	33	tumour	tumour	NN
cord-001859-d62iuk72	788	34	selectivity	selectivity	NN
cord-001859-d62iuk72	788	35	on	on	IN
cord-001859-d62iuk72	788	36	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	788	37	inhibitors	inhibitor	NNS
cord-001859-d62iuk72	788	38	Hsp90	Hsp90	NNP
cord-001859-d62iuk72	788	39	and	and	CC
cord-001859-d62iuk72	789	1	Hsp40	Hsp40	NNP
cord-001859-d62iuk72	789	2	/	/	SYM
cord-001859-d62iuk72	789	3	Erdj3	Erdj3	NNP
cord-001859-d62iuk72	789	4	are	be	VBP
cord-001859-d62iuk72	789	5	required	require	VBN
cord-001859-d62iuk72	789	6	for	for	IN
cord-001859-d62iuk72	789	7	the	the	DT
cord-001859-d62iuk72	789	8	expression	expression	NN
cord-001859-d62iuk72	789	9	and	and	CC
cord-001859-d62iuk72	789	10	anti	anti	JJ
cord-001859-d62iuk72	789	11	-	-	JJ
cord-001859-d62iuk72	789	12	apoptotic	apoptotic	JJ
cord-001859-d62iuk72	789	13	function	function	NN
cord-001859-d62iuk72	789	14	of	of	IN
cord-001859-d62iuk72	789	15	KSHV	KSHV	NNP
cord-001859-d62iuk72	789	16	K1	K1	NNP
cord-001859-d62iuk72	789	17	ICP27	ICP27	NNP
cord-001859-d62iuk72	789	18	interacts	interact	VBZ
cord-001859-d62iuk72	789	19	with	with	IN
cord-001859-d62iuk72	789	20	the	the	DT
cord-001859-d62iuk72	789	21	C	C	NNP
cord-001859-d62iuk72	789	22	-	-	HYPH
cord-001859-d62iuk72	789	23	terminal	terminal	NN
cord-001859-d62iuk72	789	24	domain	domain	NN
cord-001859-d62iuk72	789	25	of	of	IN
cord-001859-d62iuk72	789	26	RNA	RNA	NNP
cord-001859-d62iuk72	789	27	polymerase	polymerase	NN
cord-001859-d62iuk72	789	28	II	II	NNP
cord-001859-d62iuk72	789	29	and	and	CC
cord-001859-d62iuk72	789	30	facilitates	facilitate	VBZ
cord-001859-d62iuk72	789	31	its	-PRON-	PRP$
cord-001859-d62iuk72	789	32	recruitment	recruitment	NN
cord-001859-d62iuk72	789	33	to	to	IN
cord-001859-d62iuk72	789	34	herpes	herpes	NNP
cord-001859-d62iuk72	789	35	simplex	simplex	NNP
cord-001859-d62iuk72	789	36	virus	virus	NN
cord-001859-d62iuk72	789	37	1	1	CD
cord-001859-d62iuk72	789	38	transcription	transcription	NN
cord-001859-d62iuk72	789	39	sites	site	NNS
cord-001859-d62iuk72	789	40	,	,	,
cord-001859-d62iuk72	789	41	where	where	WRB
cord-001859-d62iuk72	789	42	it	-PRON-	PRP
cord-001859-d62iuk72	789	43	undergoes	undergo	VBZ
cord-001859-d62iuk72	789	44	proteasomal	proteasomal	JJ
cord-001859-d62iuk72	789	45	degradation	degradation	NN
cord-001859-d62iuk72	789	46	during	during	IN
cord-001859-d62iuk72	789	47	infection	infection	NN
cord-001859-d62iuk72	789	48	Identification	identification	NN
cord-001859-d62iuk72	789	49	of	of	IN
cord-001859-d62iuk72	789	50	proteins	protein	NNS
cord-001859-d62iuk72	789	51	in	in	IN
cord-001859-d62iuk72	789	52	human	human	JJ
cord-001859-d62iuk72	789	53	cytomegalovirus	cytomegalovirus	NN
cord-001859-d62iuk72	789	54	(	(	-LRB-
cord-001859-d62iuk72	789	55	HCMV	HCMV	NNP
cord-001859-d62iuk72	789	56	)	)	-RRB-
cord-001859-d62iuk72	789	57	particles	particle	NNS
cord-001859-d62iuk72	789	58	:	:	:
cord-001859-d62iuk72	789	59	the	the	DT
cord-001859-d62iuk72	789	60	HCMV	HCMV	NNP
cord-001859-d62iuk72	789	61	proteome	proteome	NN
cord-001859-d62iuk72	789	62	Proteins	protein	NNS
cord-001859-d62iuk72	789	63	of	of	IN
cord-001859-d62iuk72	789	64	purified	purify	VBN
cord-001859-d62iuk72	789	65	Epstein	Epstein	NNP
cord-001859-d62iuk72	789	66	-	-	HYPH
cord-001859-d62iuk72	789	67	Barr	Barr	NNP
cord-001859-d62iuk72	789	68	virus	virus	NN
cord-001859-d62iuk72	789	69	Comprehensive	comprehensive	JJ
cord-001859-d62iuk72	789	70	characterization	characterization	NN
cord-001859-d62iuk72	789	71	of	of	IN
cord-001859-d62iuk72	789	72	extracellular	extracellular	JJ
cord-001859-d62iuk72	789	73	herpes	herpes	NN
cord-001859-d62iuk72	789	74	simplex	simplex	NN
cord-001859-d62iuk72	789	75	virus	virus	NN
cord-001859-d62iuk72	789	76	type	type	NN
cord-001859-d62iuk72	789	77	1	1	CD
cord-001859-d62iuk72	789	78	virions	virion	NNS
cord-001859-d62iuk72	789	79	Analysis	Analysis	NNP
cord-001859-d62iuk72	789	80	of	of	IN
cord-001859-d62iuk72	789	81	Virion	Virion	NNP
cord-001859-d62iuk72	789	82	-	-	HYPH
cord-001859-d62iuk72	789	83	Incorporated	incorporate	VBN
cord-001859-d62iuk72	789	84	Host	host	NN
cord-001859-d62iuk72	789	85	Proteins	Proteins	NNP
cord-001859-d62iuk72	789	86	Required	require	VBN
cord-001859-d62iuk72	789	87	for	for	IN
cord-001859-d62iuk72	789	88	Herpes	Herpes	NNP
cord-001859-d62iuk72	789	89	Simplex	Simplex	NNP
cord-001859-d62iuk72	789	90	Virus	Virus	NNP
cord-001859-d62iuk72	789	91	Type	type	NN
cord-001859-d62iuk72	789	92	1	1	CD
cord-001859-d62iuk72	789	93	Infection	infection	NN
cord-001859-d62iuk72	789	94	through	through	IN
cord-001859-d62iuk72	789	95	a	a	DT
cord-001859-d62iuk72	789	96	RNA	RNA	NNP
cord-001859-d62iuk72	789	97	Interference	Interference	NNP
cord-001859-d62iuk72	789	98	Screen	Screen	NNP
cord-001859-d62iuk72	789	99	An	an	DT
cord-001859-d62iuk72	789	100	Interaction	interaction	NN
cord-001859-d62iuk72	789	101	between	between	IN
cord-001859-d62iuk72	789	102	KSHV	KSHV	NNP
cord-001859-d62iuk72	789	103	ORF57	ORF57	NNP
cord-001859-d62iuk72	789	104	and	and	CC
cord-001859-d62iuk72	789	105	UIF	UIF	NNP
cord-001859-d62iuk72	790	1	Provides	provide	VBZ
cord-001859-d62iuk72	790	2	mRNA	mrna	NN
cord-001859-d62iuk72	790	3	-	-	HYPH
cord-001859-d62iuk72	790	4	Adaptor	adaptor	NN
cord-001859-d62iuk72	790	5	Redundancy	Redundancy	NNP
cord-001859-d62iuk72	790	6	in	in	IN
cord-001859-d62iuk72	790	7	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	790	8	Intronless	Intronless	NNP
cord-001859-d62iuk72	790	9	mRNA	mRNA	NNP
cord-001859-d62iuk72	790	10	Export	Export	NNP
cord-001859-d62iuk72	790	11	Identification	Identification	NNP
cord-001859-d62iuk72	790	12	of	of	IN
cord-001859-d62iuk72	790	13	a	a	DT
cord-001859-d62iuk72	790	14	cis	cis	NN
cord-001859-d62iuk72	790	15	-	-	HYPH
cord-001859-d62iuk72	790	16	acting	act	VBG
cord-001859-d62iuk72	790	17	element	element	NN
cord-001859-d62iuk72	790	18	within	within	IN
cord-001859-d62iuk72	790	19	the	the	DT
cord-001859-d62iuk72	790	20	herpesvirus	herpesvirus	NNP
cord-001859-d62iuk72	790	21	saimiri	saimiri	NNP
cord-001859-d62iuk72	790	22	ORF	ORF	NNP
cord-001859-d62iuk72	790	23	6	6	CD
cord-001859-d62iuk72	790	24	promoter	promoter	NN
cord-001859-d62iuk72	790	25	that	that	WDT
cord-001859-d62iuk72	790	26	is	be	VBZ
cord-001859-d62iuk72	790	27	responsive	responsive	JJ
cord-001859-d62iuk72	790	28	to	to	IN
cord-001859-d62iuk72	790	29	the	the	DT
cord-001859-d62iuk72	790	30	HVS.R	HVS.R	NNPS
cord-001859-d62iuk72	790	31	transactivator	transactivator	VBP
cord-001859-d62iuk72	790	32	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	790	33	's	's	POS
cord-001859-d62iuk72	790	34	sarcoma	sarcoma	NN
cord-001859-d62iuk72	790	35	-	-	HYPH
cord-001859-d62iuk72	790	36	associated	associate	VBN
cord-001859-d62iuk72	790	37	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	790	38	(	(	-LRB-
cord-001859-d62iuk72	790	39	KSHV	KSHV	NNP
cord-001859-d62iuk72	790	40	)	)	-RRB-
cord-001859-d62iuk72	790	41	Rta	Rta	NNP
cord-001859-d62iuk72	790	42	and	and	CC
cord-001859-d62iuk72	790	43	cellular	cellular	JJ
cord-001859-d62iuk72	790	44	HMGB1	hmgb1	NN
cord-001859-d62iuk72	790	45	proteins	protein	NNS
cord-001859-d62iuk72	790	46	synergistically	synergistically	RB
cord-001859-d62iuk72	790	47	transactivate	transactivate	VBP
cord-001859-d62iuk72	790	48	the	the	DT
cord-001859-d62iuk72	790	49	KSHV	KSHV	NNP
cord-001859-d62iuk72	790	50	ORF50	ORF50	NNP
cord-001859-d62iuk72	790	51	promoter	promoter	NN
cord-001859-d62iuk72	790	52	Merkel	Merkel	NNP
cord-001859-d62iuk72	790	53	Cell	Cell	NNP
cord-001859-d62iuk72	790	54	Polyomavirus	Polyomavirus	NNP
cord-001859-d62iuk72	791	1	Small	small	JJ
cord-001859-d62iuk72	791	2	T	t	NN
cord-001859-d62iuk72	791	3	Antigen	antigen	NN
cord-001859-d62iuk72	791	4	Mediates	mediate	VBZ
cord-001859-d62iuk72	791	5	Microtubule	Microtubule	NNP
cord-001859-d62iuk72	791	6	Destabilization	destabilization	NN
cord-001859-d62iuk72	792	1	To	to	TO
cord-001859-d62iuk72	792	2	Promote	promote	VB
cord-001859-d62iuk72	792	3	Cell	cell	NN
cord-001859-d62iuk72	792	4	Motility	motility	NN
cord-001859-d62iuk72	792	5	and	and	CC
cord-001859-d62iuk72	792	6	Migration	migration	NN
cord-001859-d62iuk72	793	1	The	the	DT
cord-001859-d62iuk72	793	2	activation	activation	NN
cord-001859-d62iuk72	793	3	domain	domain	NN
cord-001859-d62iuk72	793	4	of	of	IN
cord-001859-d62iuk72	793	5	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	793	6	saimiri	saimiri	NNP
cord-001859-d62iuk72	793	7	R	r	NN
cord-001859-d62iuk72	793	8	protein	protein	NN
cord-001859-d62iuk72	793	9	interacts	interact	VBZ
cord-001859-d62iuk72	793	10	with	with	IN
cord-001859-d62iuk72	793	11	the	the	DT
cord-001859-d62iuk72	793	12	TATA	TATA	NNP
cord-001859-d62iuk72	793	13	-	-	HYPH
cord-001859-d62iuk72	793	14	binding	bind	VBG
cord-001859-d62iuk72	793	15	protein	protein	NN
cord-001859-d62iuk72	794	1	The	the	DT
cord-001859-d62iuk72	794	2	Cellular	Cellular	NNP
cord-001859-d62iuk72	794	3	Interactome	Interactome	NNP
cord-001859-d62iuk72	794	4	of	of	IN
cord-001859-d62iuk72	794	5	the	the	DT
cord-001859-d62iuk72	794	6	Coronavirus	Coronavirus	NNP
cord-001859-d62iuk72	794	7	Infectious	Infectious	NNP
cord-001859-d62iuk72	794	8	Bronchitis	Bronchitis	NNP
cord-001859-d62iuk72	795	1	Virus	Virus	NNP
cord-001859-d62iuk72	795	2	Nucleocapsid	Nucleocapsid	NNP
cord-001859-d62iuk72	795	3	Protein	Protein	NNP
cord-001859-d62iuk72	795	4	and	and	CC
cord-001859-d62iuk72	795	5	Functional	Functional	NNP
cord-001859-d62iuk72	795	6	Implications	Implications	NNPS
cord-001859-d62iuk72	795	7	for	for	IN
cord-001859-d62iuk72	795	8	Virus	Virus	NNP
cord-001859-d62iuk72	795	9	Biology	Biology	NNP
cord-001859-d62iuk72	796	1	The	the	DT
cord-001859-d62iuk72	796	2	carboxy	carboxy	JJ
cord-001859-d62iuk72	796	3	terminus	terminus	NN
cord-001859-d62iuk72	796	4	of	of	IN
cord-001859-d62iuk72	796	5	the	the	DT
cord-001859-d62iuk72	796	6	herpesvirus	herpesvirus	NNP
cord-001859-d62iuk72	796	7	saimiri	saimiri	NNP
cord-001859-d62iuk72	796	8	ORF	ORF	NNP
cord-001859-d62iuk72	796	9	57	57	CD
cord-001859-d62iuk72	796	10	gene	gene	NN
cord-001859-d62iuk72	796	11	contains	contain	VBZ
cord-001859-d62iuk72	796	12	domains	domain	NNS
cord-001859-d62iuk72	796	13	that	that	WDT
cord-001859-d62iuk72	796	14	are	be	VBP
cord-001859-d62iuk72	796	15	required	require	VBN
cord-001859-d62iuk72	796	16	for	for	IN
cord-001859-d62iuk72	796	17	transactivation	transactivation	NN
cord-001859-d62iuk72	796	18	and	and	CC
cord-001859-d62iuk72	796	19	transrepression	transrepression	NN
cord-001859-d62iuk72	796	20	A	a	DT
cord-001859-d62iuk72	796	21	γ-2	γ-2	NN
cord-001859-d62iuk72	796	22	Herpesvirus	Herpesvirus	NNP
cord-001859-d62iuk72	796	23	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-001859-d62iuk72	796	24	Shuttle	Shuttle	NNP
cord-001859-d62iuk72	796	25	Protein	Protein	NNP
cord-001859-d62iuk72	796	26	Interacts	interact	VBZ
cord-001859-d62iuk72	796	27	with	with	IN
cord-001859-d62iuk72	796	28	Importin	Importin	NNP
cord-001859-d62iuk72	796	29	α1	α1	NN
cord-001859-d62iuk72	796	30	and	and	CC
cord-001859-d62iuk72	796	31	α5	α5	NNP
cord-001859-d62iuk72	796	32	Nucleolar	Nucleolar	NNP
cord-001859-d62iuk72	796	33	disruption	disruption	NN
cord-001859-d62iuk72	796	34	impairs	impair	VBZ
cord-001859-d62iuk72	797	1	Kaposi	Kaposi	NNP
cord-001859-d62iuk72	797	2	's	's	POS
cord-001859-d62iuk72	797	3	sarcoma	sarcoma	NN
cord-001859-d62iuk72	797	4	-	-	HYPH
cord-001859-d62iuk72	797	5	associated	associate	VBN
cord-001859-d62iuk72	797	6	herpesvirus	herpesvirus	NN
cord-001859-d62iuk72	797	7	ORF57-mediated	orf57-mediate	VBN
cord-001859-d62iuk72	797	8	nuclear	nuclear	JJ
cord-001859-d62iuk72	797	9	export	export	NN
cord-001859-d62iuk72	797	10	of	of	IN
cord-001859-d62iuk72	797	11	intronless	intronless	JJ
cord-001859-d62iuk72	797	12	viral	viral	NN
cord-001859-d62iuk72	797	13	mRNAs	mrnas	$
cord-001859-d62iuk72	797	14	Merkel	Merkel	NNP
cord-001859-d62iuk72	797	15	Cell	Cell	NNP
cord-001859-d62iuk72	797	16	Polyomavirus	Polyomavirus	NNP
cord-001859-d62iuk72	797	17	Small	small	JJ
cord-001859-d62iuk72	797	18	T	T	NNP
cord-001859-d62iuk72	797	19	Antigen	Antigen	NNP
cord-001859-d62iuk72	797	20	Targets	target	VBZ
cord-001859-d62iuk72	797	21	the	the	DT
cord-001859-d62iuk72	797	22	NEMO	NEMO	NNP
cord-001859-d62iuk72	797	23	Adaptor	Adaptor	NNP
cord-001859-d62iuk72	797	24	Protein	Protein	NNP
cord-001859-d62iuk72	798	1	To	to	TO
cord-001859-d62iuk72	798	2	Disrupt	disrupt	VB
cord-001859-d62iuk72	798	3	Inflammatory	inflammatory	NN
cord-001859-d62iuk72	798	4	Signaling	signaling	NN
cord-001859-d62iuk72	799	1	We	-PRON-	PRP
cord-001859-d62iuk72	799	2	are	be	VBP
cord-001859-d62iuk72	799	3	grateful	grateful	JJ
cord-001859-d62iuk72	799	4	to	to	IN
cord-001859-d62iuk72	799	5	members	member	NNS
cord-001859-d62iuk72	799	6	of	of	IN
cord-001859-d62iuk72	799	7	the	the	DT
cord-001859-d62iuk72	799	8	Whitehouse	Whitehouse	NNP
cord-001859-d62iuk72	799	9	laboratory	laboratory	NN
cord-001859-d62iuk72	799	10	for	for	IN
cord-001859-d62iuk72	799	11	helpful	helpful	JJ
cord-001859-d62iuk72	799	12	discussions	discussion	NNS
cord-001859-d62iuk72	799	13	,	,	,
cord-001859-d62iuk72	799	14	especially	especially	RB
cord-001859-d62iuk72	799	15	to	to	IN
cord-001859-d62iuk72	799	16	Alexander	Alexander	NNP
cord-001859-d62iuk72	799	17	J.	J.	NNP
cord-001859-d62iuk72	799	18	Coleman	Coleman	NNP
cord-001859-d62iuk72	799	19	for	for	IN
cord-001859-d62iuk72	799	20	guidance	guidance	NN
cord-001859-d62iuk72	799	21	with	with	IN
cord-001859-d62iuk72	799	22	confocal	confocal	JJ
cord-001859-d62iuk72	799	23	profiling	profiling	NN
cord-001859-d62iuk72	799	24	.	.	.
cord-001859-d62iuk72	800	1	The	the	DT
cord-001859-d62iuk72	800	2	authors	author	NNS
cord-001859-d62iuk72	800	3	would	would	MD
cord-001859-d62iuk72	800	4	like	like	VB
cord-001859-d62iuk72	800	5	to	to	TO
cord-001859-d62iuk72	800	6	thank	thank	VB
cord-001859-d62iuk72	800	7	 	 	_SP