id	sid	tid	token	lemma	pos
cord-002530-ao7kenbx	1	1	key	key	JJ
cord-002530-ao7kenbx	1	2	:	:	:
cord-002530-ao7kenbx	1	3	cord-002530-ao7kenbx	cord-002530-ao7kenbx	NFP
cord-002530-ao7kenbx	1	4	authors	author	NNS
cord-002530-ao7kenbx	1	5	:	:	:
cord-002530-ao7kenbx	1	6	Lin	Lin	NNP
cord-002530-ao7kenbx	1	7	,	,	,
cord-002530-ao7kenbx	1	8	Yao	Yao	NNP
cord-002530-ao7kenbx	1	9	-	-	HYPH
cord-002530-ao7kenbx	1	10	Tang	Tang	NNP
cord-002530-ao7kenbx	1	11	;	;	:
cord-002530-ao7kenbx	1	12	Prendergast	Prendergast	NNP
cord-002530-ao7kenbx	1	13	,	,	,
cord-002530-ao7kenbx	1	14	James	James	NNP
cord-002530-ao7kenbx	1	15	;	;	:
cord-002530-ao7kenbx	1	16	Grey	Grey	NNP
cord-002530-ao7kenbx	1	17	,	,	,
cord-002530-ao7kenbx	1	18	Finn	Finn	NNP
cord-002530-ao7kenbx	2	1	title	title	NN
cord-002530-ao7kenbx	2	2	:	:	:
cord-002530-ao7kenbx	3	1	The	the	DT
cord-002530-ao7kenbx	3	2	host	host	NN
cord-002530-ao7kenbx	3	3	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	3	4	-	-	HYPH
cord-002530-ao7kenbx	3	5	dependent	dependent	JJ
cord-002530-ao7kenbx	3	6	segregase	segregase	NN
cord-002530-ao7kenbx	3	7	VCP	VCP	NNP
cord-002530-ao7kenbx	3	8	/	/	SYM
cord-002530-ao7kenbx	3	9	p97	p97	CD
cord-002530-ao7kenbx	3	10	is	be	VBZ
cord-002530-ao7kenbx	3	11	required	require	VBN
cord-002530-ao7kenbx	3	12	for	for	IN
cord-002530-ao7kenbx	3	13	the	the	DT
cord-002530-ao7kenbx	3	14	onset	onset	NN
cord-002530-ao7kenbx	3	15	of	of	IN
cord-002530-ao7kenbx	3	16	human	human	JJ
cord-002530-ao7kenbx	3	17	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	3	18	replication	replication	NN
cord-002530-ao7kenbx	3	19	date	date	NN
cord-002530-ao7kenbx	3	20	:	:	:
cord-002530-ao7kenbx	3	21	2017	2017	CD
cord-002530-ao7kenbx	3	22	-	-	HYPH
cord-002530-ao7kenbx	3	23	05	05	CD
cord-002530-ao7kenbx	3	24	-	-	HYPH
cord-002530-ao7kenbx	3	25	11	11	CD
cord-002530-ao7kenbx	3	26	journal	journal	NN
cord-002530-ao7kenbx	3	27	:	:	:
cord-002530-ao7kenbx	3	28	PLoS	PLoS	NNP
cord-002530-ao7kenbx	3	29	Pathog	Pathog	NNP
cord-002530-ao7kenbx	3	30	DOI	DOI	NNP
cord-002530-ao7kenbx	3	31	:	:	:
cord-002530-ao7kenbx	3	32	10.1371	10.1371	CD
cord-002530-ao7kenbx	3	33	/	/	SYM
cord-002530-ao7kenbx	3	34	journal.ppat.1006329	journal.ppat.1006329	NNP
cord-002530-ao7kenbx	3	35	sha	sha	NNP
cord-002530-ao7kenbx	3	36	:	:	:
cord-002530-ao7kenbx	3	37	621c8306765f418717c3de4497c2dace5f8a9c73	621c8306765f418717c3de4497c2dace5f8a9c73	CD
cord-002530-ao7kenbx	3	38	doc_id	doc_id	CD
cord-002530-ao7kenbx	3	39	:	:	:
cord-002530-ao7kenbx	3	40	2530	2530	CD
cord-002530-ao7kenbx	3	41	cord_uid	cord_uid	NNS
cord-002530-ao7kenbx	3	42	:	:	:
cord-002530-ao7kenbx	4	1	ao7kenbx	ao7kenbx	.
cord-002530-ao7kenbx	5	1	The	the	DT
cord-002530-ao7kenbx	5	2	human	human	JJ
cord-002530-ao7kenbx	5	3	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	5	4	major	major	JJ
cord-002530-ao7kenbx	5	5	immediate	immediate	JJ
cord-002530-ao7kenbx	5	6	early	early	JJ
cord-002530-ao7kenbx	5	7	proteins	protein	NNS
cord-002530-ao7kenbx	5	8	IE1	ie1	NN
cord-002530-ao7kenbx	5	9	and	and	CC
cord-002530-ao7kenbx	5	10	IE2	ie2	NN
cord-002530-ao7kenbx	5	11	are	be	VBP
cord-002530-ao7kenbx	5	12	critical	critical	JJ
cord-002530-ao7kenbx	5	13	drivers	driver	NNS
cord-002530-ao7kenbx	5	14	of	of	IN
cord-002530-ao7kenbx	5	15	virus	virus	NN
cord-002530-ao7kenbx	5	16	replication	replication	NN
cord-002530-ao7kenbx	5	17	and	and	CC
cord-002530-ao7kenbx	5	18	are	be	VBP
cord-002530-ao7kenbx	5	19	considered	consider	VBN
cord-002530-ao7kenbx	5	20	pivotal	pivotal	JJ
cord-002530-ao7kenbx	5	21	in	in	IN
cord-002530-ao7kenbx	5	22	determining	determine	VBG
cord-002530-ao7kenbx	5	23	the	the	DT
cord-002530-ao7kenbx	5	24	balance	balance	NN
cord-002530-ao7kenbx	5	25	between	between	IN
cord-002530-ao7kenbx	5	26	productive	productive	JJ
cord-002530-ao7kenbx	5	27	and	and	CC
cord-002530-ao7kenbx	5	28	latent	latent	JJ
cord-002530-ao7kenbx	5	29	infection	infection	NN
cord-002530-ao7kenbx	5	30	.	.	.
cord-002530-ao7kenbx	6	1	IE1	ie1	NN
cord-002530-ao7kenbx	6	2	and	and	CC
cord-002530-ao7kenbx	6	3	IE2	ie2	NN
cord-002530-ao7kenbx	6	4	are	be	VBP
cord-002530-ao7kenbx	6	5	derived	derive	VBN
cord-002530-ao7kenbx	6	6	from	from	IN
cord-002530-ao7kenbx	6	7	the	the	DT
cord-002530-ao7kenbx	6	8	same	same	JJ
cord-002530-ao7kenbx	6	9	primary	primary	JJ
cord-002530-ao7kenbx	6	10	transcript	transcript	NN
cord-002530-ao7kenbx	6	11	by	by	IN
cord-002530-ao7kenbx	6	12	alternative	alternative	JJ
cord-002530-ao7kenbx	6	13	splicing	splicing	NN
cord-002530-ao7kenbx	6	14	and	and	CC
cord-002530-ao7kenbx	6	15	regulation	regulation	NN
cord-002530-ao7kenbx	6	16	of	of	IN
cord-002530-ao7kenbx	6	17	their	-PRON-	PRP$
cord-002530-ao7kenbx	6	18	expression	expression	NN
cord-002530-ao7kenbx	6	19	likely	likely	RB
cord-002530-ao7kenbx	6	20	involves	involve	VBZ
cord-002530-ao7kenbx	6	21	a	a	DT
cord-002530-ao7kenbx	6	22	complex	complex	JJ
cord-002530-ao7kenbx	6	23	interplay	interplay	NN
cord-002530-ao7kenbx	6	24	between	between	IN
cord-002530-ao7kenbx	6	25	cellular	cellular	JJ
cord-002530-ao7kenbx	6	26	and	and	CC
cord-002530-ao7kenbx	6	27	viral	viral	JJ
cord-002530-ao7kenbx	6	28	factors	factor	NNS
cord-002530-ao7kenbx	6	29	.	.	.
cord-002530-ao7kenbx	7	1	Here	here	RB
cord-002530-ao7kenbx	7	2	we	-PRON-	PRP
cord-002530-ao7kenbx	7	3	show	show	VBP
cord-002530-ao7kenbx	7	4	that	that	IN
cord-002530-ao7kenbx	7	5	knockdown	knockdown	NN
cord-002530-ao7kenbx	7	6	of	of	IN
cord-002530-ao7kenbx	7	7	the	the	DT
cord-002530-ao7kenbx	7	8	host	host	NN
cord-002530-ao7kenbx	7	9	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	7	10	-	-	HYPH
cord-002530-ao7kenbx	7	11	dependent	dependent	JJ
cord-002530-ao7kenbx	7	12	segregase	segregase	NN
cord-002530-ao7kenbx	7	13	VCP	VCP	NNP
cord-002530-ao7kenbx	7	14	/	/	SYM
cord-002530-ao7kenbx	7	15	p97	p97	CD
cord-002530-ao7kenbx	7	16	,	,	,
cord-002530-ao7kenbx	7	17	results	result	NNS
cord-002530-ao7kenbx	7	18	in	in	IN
cord-002530-ao7kenbx	7	19	loss	loss	NN
cord-002530-ao7kenbx	7	20	of	of	IN
cord-002530-ao7kenbx	7	21	IE2	ie2	JJ
cord-002530-ao7kenbx	7	22	expression	expression	NN
cord-002530-ao7kenbx	7	23	,	,	,
cord-002530-ao7kenbx	7	24	subsequent	subsequent	JJ
cord-002530-ao7kenbx	7	25	suppression	suppression	NN
cord-002530-ao7kenbx	7	26	of	of	IN
cord-002530-ao7kenbx	7	27	early	early	JJ
cord-002530-ao7kenbx	7	28	and	and	CC
cord-002530-ao7kenbx	7	29	late	late	JJ
cord-002530-ao7kenbx	7	30	gene	gene	NN
cord-002530-ao7kenbx	7	31	expression	expression	NN
cord-002530-ao7kenbx	7	32	and	and	CC
cord-002530-ao7kenbx	7	33	,	,	,
cord-002530-ao7kenbx	7	34	ultimately	ultimately	RB
cord-002530-ao7kenbx	7	35	,	,	,
cord-002530-ao7kenbx	7	36	failure	failure	NN
cord-002530-ao7kenbx	7	37	in	in	IN
cord-002530-ao7kenbx	7	38	virus	virus	NN
cord-002530-ao7kenbx	7	39	replication	replication	NN
cord-002530-ao7kenbx	7	40	.	.	.
cord-002530-ao7kenbx	8	1	RNAseq	RNAseq	NNP
cord-002530-ao7kenbx	8	2	analysis	analysis	NN
cord-002530-ao7kenbx	8	3	showed	show	VBD
cord-002530-ao7kenbx	8	4	increased	increase	VBN
cord-002530-ao7kenbx	8	5	levels	level	NNS
cord-002530-ao7kenbx	8	6	of	of	IN
cord-002530-ao7kenbx	8	7	IE1	ie1	NN
cord-002530-ao7kenbx	8	8	splicing	splicing	NN
cord-002530-ao7kenbx	8	9	,	,	,
cord-002530-ao7kenbx	8	10	with	with	IN
cord-002530-ao7kenbx	8	11	a	a	DT
cord-002530-ao7kenbx	8	12	corresponding	corresponding	JJ
cord-002530-ao7kenbx	8	13	decrease	decrease	NN
cord-002530-ao7kenbx	8	14	in	in	IN
cord-002530-ao7kenbx	8	15	IE2	ie2	NN
cord-002530-ao7kenbx	8	16	splicing	splicing	NN
cord-002530-ao7kenbx	8	17	following	follow	VBG
cord-002530-ao7kenbx	8	18	VCP	VCP	NNP
cord-002530-ao7kenbx	8	19	knockdown	knockdown	NN
cord-002530-ao7kenbx	8	20	.	.	.
cord-002530-ao7kenbx	9	1	Global	global	JJ
cord-002530-ao7kenbx	9	2	analysis	analysis	NN
cord-002530-ao7kenbx	9	3	of	of	IN
cord-002530-ao7kenbx	9	4	viral	viral	JJ
cord-002530-ao7kenbx	9	5	transcription	transcription	NN
cord-002530-ao7kenbx	9	6	showed	show	VBD
cord-002530-ao7kenbx	9	7	the	the	DT
cord-002530-ao7kenbx	9	8	expression	expression	NN
cord-002530-ao7kenbx	9	9	of	of	IN
cord-002530-ao7kenbx	9	10	a	a	DT
cord-002530-ao7kenbx	9	11	subset	subset	NN
cord-002530-ao7kenbx	9	12	of	of	IN
cord-002530-ao7kenbx	9	13	viral	viral	JJ
cord-002530-ao7kenbx	9	14	genes	gene	NNS
cord-002530-ao7kenbx	9	15	is	be	VBZ
cord-002530-ao7kenbx	9	16	not	not	RB
cord-002530-ao7kenbx	9	17	reduced	reduce	VBN
cord-002530-ao7kenbx	9	18	despite	despite	IN
cord-002530-ao7kenbx	9	19	the	the	DT
cord-002530-ao7kenbx	9	20	loss	loss	NN
cord-002530-ao7kenbx	9	21	of	of	IN
cord-002530-ao7kenbx	9	22	IE2	ie2	JJ
cord-002530-ao7kenbx	9	23	expression	expression	NN
cord-002530-ao7kenbx	9	24	,	,	,
cord-002530-ao7kenbx	9	25	including	include	VBG
cord-002530-ao7kenbx	9	26	UL112/113	ul112/113	CD
cord-002530-ao7kenbx	9	27	.	.	.
cord-002530-ao7kenbx	10	1	Furthermore	furthermore	RB
cord-002530-ao7kenbx	10	2	,	,	,
cord-002530-ao7kenbx	10	3	Immunofluorescence	Immunofluorescence	NNP
cord-002530-ao7kenbx	10	4	studies	study	NNS
cord-002530-ao7kenbx	10	5	demonstrated	demonstrate	VBD
cord-002530-ao7kenbx	10	6	that	that	IN
cord-002530-ao7kenbx	10	7	VCP	VCP	NNP
cord-002530-ao7kenbx	10	8	strongly	strongly	RB
cord-002530-ao7kenbx	10	9	colocalised	colocalise	VBN
cord-002530-ao7kenbx	10	10	with	with	IN
cord-002530-ao7kenbx	10	11	the	the	DT
cord-002530-ao7kenbx	10	12	viral	viral	JJ
cord-002530-ao7kenbx	10	13	replication	replication	NN
cord-002530-ao7kenbx	10	14	compartments	compartment	NNS
cord-002530-ao7kenbx	10	15	in	in	IN
cord-002530-ao7kenbx	10	16	the	the	DT
cord-002530-ao7kenbx	10	17	nucleus	nucleus	NN
cord-002530-ao7kenbx	10	18	.	.	.
cord-002530-ao7kenbx	11	1	Finally	finally	RB
cord-002530-ao7kenbx	11	2	,	,	,
cord-002530-ao7kenbx	11	3	we	-PRON-	PRP
cord-002530-ao7kenbx	11	4	show	show	VBP
cord-002530-ao7kenbx	11	5	that	that	IN
cord-002530-ao7kenbx	11	6	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	11	7	,	,	,
cord-002530-ao7kenbx	11	8	a	a	DT
cord-002530-ao7kenbx	11	9	small	small	JJ
cord-002530-ao7kenbx	11	10	molecule	molecule	NN
cord-002530-ao7kenbx	11	11	inhibitor	inhibitor	NN
cord-002530-ao7kenbx	11	12	of	of	IN
cord-002530-ao7kenbx	11	13	VCP	VCP	NNP
cord-002530-ao7kenbx	11	14	,	,	,
cord-002530-ao7kenbx	11	15	is	be	VBZ
cord-002530-ao7kenbx	11	16	a	a	DT
cord-002530-ao7kenbx	11	17	potent	potent	JJ
cord-002530-ao7kenbx	11	18	HCMV	hcmv	NN
cord-002530-ao7kenbx	11	19	antiviral	antiviral	JJ
cord-002530-ao7kenbx	11	20	with	with	IN
cord-002530-ao7kenbx	11	21	potential	potential	NN
cord-002530-ao7kenbx	11	22	as	as	IN
cord-002530-ao7kenbx	11	23	a	a	DT
cord-002530-ao7kenbx	11	24	novel	novel	JJ
cord-002530-ao7kenbx	11	25	host	host	NN
cord-002530-ao7kenbx	11	26	targeting	target	VBG
cord-002530-ao7kenbx	11	27	therapeutic	therapeutic	JJ
cord-002530-ao7kenbx	11	28	for	for	IN
cord-002530-ao7kenbx	11	29	HCMV	HCMV	NNP
cord-002530-ao7kenbx	11	30	infection	infection	NN
cord-002530-ao7kenbx	11	31	.	.	.
cord-002530-ao7kenbx	12	1	Viruses	virus	NNS
cord-002530-ao7kenbx	12	2	are	be	VBP
cord-002530-ao7kenbx	12	3	obligate	obligate	VBN
cord-002530-ao7kenbx	12	4	intracellular	intracellular	JJ
cord-002530-ao7kenbx	12	5	pathogens	pathogen	NNS
cord-002530-ao7kenbx	12	6	,	,	,
cord-002530-ao7kenbx	12	7	meaning	mean	VBG
cord-002530-ao7kenbx	12	8	that	that	IN
cord-002530-ao7kenbx	12	9	they	-PRON-	PRP
cord-002530-ao7kenbx	12	10	are	be	VBP
cord-002530-ao7kenbx	12	11	completely	completely	RB
cord-002530-ao7kenbx	12	12	dependent	dependent	JJ
cord-002530-ao7kenbx	12	13	on	on	IN
cord-002530-ao7kenbx	12	14	the	the	DT
cord-002530-ao7kenbx	12	15	host	host	NN
cord-002530-ao7kenbx	12	16	cellular	cellular	JJ
cord-002530-ao7kenbx	12	17	machinery	machinery	NN
cord-002530-ao7kenbx	12	18	to	to	TO
cord-002530-ao7kenbx	12	19	replicate	replicate	VB
cord-002530-ao7kenbx	12	20	.	.	.
cord-002530-ao7kenbx	13	1	Identifying	identify	VBG
cord-002530-ao7kenbx	13	2	which	which	WDT
cord-002530-ao7kenbx	13	3	host	host	NN
cord-002530-ao7kenbx	13	4	genes	gene	NNS
cord-002530-ao7kenbx	13	5	are	be	VBP
cord-002530-ao7kenbx	13	6	necessary	necessary	JJ
cord-002530-ao7kenbx	13	7	for	for	IN
cord-002530-ao7kenbx	13	8	virus	virus	NN
cord-002530-ao7kenbx	13	9	replication	replication	NN
cord-002530-ao7kenbx	13	10	extends	extend	VBZ
cord-002530-ao7kenbx	13	11	our	-PRON-	PRP$
cord-002530-ao7kenbx	13	12	understanding	understanding	NN
cord-002530-ao7kenbx	13	13	of	of	IN
cord-002530-ao7kenbx	13	14	how	how	WRB
cord-002530-ao7kenbx	13	15	viruses	virus	NNS
cord-002530-ao7kenbx	13	16	replicate	replicate	VBP
cord-002530-ao7kenbx	13	17	,	,	,
cord-002530-ao7kenbx	13	18	how	how	WRB
cord-002530-ao7kenbx	13	19	cells	cell	NNS
cord-002530-ao7kenbx	13	20	function	function	VBP
cord-002530-ao7kenbx	13	21	and	and	CC
cord-002530-ao7kenbx	13	22	provides	provide	VBZ
cord-002530-ao7kenbx	13	23	potential	potential	JJ
cord-002530-ao7kenbx	13	24	targets	target	NNS
cord-002530-ao7kenbx	13	25	for	for	IN
cord-002530-ao7kenbx	13	26	novel	novel	JJ
cord-002530-ao7kenbx	13	27	antivirals	antiviral	NNS
cord-002530-ao7kenbx	13	28	.	.	.
cord-002530-ao7kenbx	14	1	Here	here	RB
cord-002530-ao7kenbx	14	2	,	,	,
cord-002530-ao7kenbx	14	3	we	-PRON-	PRP
cord-002530-ao7kenbx	14	4	show	show	VBP
cord-002530-ao7kenbx	14	5	that	that	IN
cord-002530-ao7kenbx	14	6	a	a	DT
cord-002530-ao7kenbx	14	7	cellular	cellular	JJ
cord-002530-ao7kenbx	14	8	factor	factor	NN
cord-002530-ao7kenbx	14	9	called	call	VBN
cord-002530-ao7kenbx	14	10	valosin	valosin	NNP
cord-002530-ao7kenbx	14	11	containing	contain	VBG
cord-002530-ao7kenbx	14	12	protein	protein	NN
cord-002530-ao7kenbx	14	13	(	(	-LRB-
cord-002530-ao7kenbx	14	14	VCP	VCP	NNP
cord-002530-ao7kenbx	14	15	)	)	-RRB-
cord-002530-ao7kenbx	14	16	is	be	VBZ
cord-002530-ao7kenbx	14	17	essential	essential	JJ
cord-002530-ao7kenbx	14	18	for	for	IN
cord-002530-ao7kenbx	14	19	human	human	JJ
cord-002530-ao7kenbx	14	20	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	14	21	replication	replication	NN
cord-002530-ao7kenbx	14	22	.	.	.
cord-002530-ao7kenbx	15	1	We	-PRON-	PRP
cord-002530-ao7kenbx	15	2	demonstrate	demonstrate	VBP
cord-002530-ao7kenbx	15	3	that	that	IN
cord-002530-ao7kenbx	15	4	VCP	VCP	NNP
cord-002530-ao7kenbx	15	5	is	be	VBZ
cord-002530-ao7kenbx	15	6	required	require	VBN
cord-002530-ao7kenbx	15	7	for	for	IN
cord-002530-ao7kenbx	15	8	the	the	DT
cord-002530-ao7kenbx	15	9	expression	expression	NN
cord-002530-ao7kenbx	15	10	of	of	IN
cord-002530-ao7kenbx	15	11	an	an	DT
cord-002530-ao7kenbx	15	12	essential	essential	JJ
cord-002530-ao7kenbx	15	13	virus	virus	NN
cord-002530-ao7kenbx	15	14	gene	gene	NN
cord-002530-ao7kenbx	15	15	called	call	VBN
cord-002530-ao7kenbx	15	16	IE2	IE2	NNP
cord-002530-ao7kenbx	15	17	.	.	.
cord-002530-ao7kenbx	16	1	Finally	finally	RB
cord-002530-ao7kenbx	16	2	we	-PRON-	PRP
cord-002530-ao7kenbx	16	3	show	show	VBP
cord-002530-ao7kenbx	16	4	that	that	IN
cord-002530-ao7kenbx	16	5	a	a	DT
cord-002530-ao7kenbx	16	6	chemical	chemical	JJ
cord-002530-ao7kenbx	16	7	inhibitor	inhibitor	NN
cord-002530-ao7kenbx	16	8	of	of	IN
cord-002530-ao7kenbx	16	9	VCP	VCP	NNP
cord-002530-ao7kenbx	16	10	is	be	VBZ
cord-002530-ao7kenbx	16	11	a	a	DT
cord-002530-ao7kenbx	16	12	potent	potent	JJ
cord-002530-ao7kenbx	16	13	antiviral	antiviral	JJ
cord-002530-ao7kenbx	16	14	against	against	IN
cord-002530-ao7kenbx	16	15	human	human	JJ
cord-002530-ao7kenbx	16	16	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	16	17	,	,	,
cord-002530-ao7kenbx	16	18	demonstrating	demonstrate	VBG
cord-002530-ao7kenbx	16	19	the	the	DT
cord-002530-ao7kenbx	16	20	potential	potential	NN
cord-002530-ao7kenbx	16	21	for	for	IN
cord-002530-ao7kenbx	16	22	VCP	VCP	NNP
cord-002530-ao7kenbx	16	23	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	16	24	as	as	IN
cord-002530-ao7kenbx	16	25	novel	novel	JJ
cord-002530-ao7kenbx	16	26	therapeutics	therapeutic	NNS
cord-002530-ao7kenbx	16	27	against	against	IN
cord-002530-ao7kenbx	16	28	this	this	DT
cord-002530-ao7kenbx	16	29	virus	virus	NN
cord-002530-ao7kenbx	16	30	.	.	.
cord-002530-ao7kenbx	17	1	Human	human	JJ
cord-002530-ao7kenbx	17	2	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	17	3	(	(	-LRB-
cord-002530-ao7kenbx	17	4	HCMV	HCMV	NNP
cord-002530-ao7kenbx	17	5	)	)	-RRB-
cord-002530-ao7kenbx	17	6	is	be	VBZ
cord-002530-ao7kenbx	17	7	a	a	DT
cord-002530-ao7kenbx	17	8	highly	highly	RB
cord-002530-ao7kenbx	17	9	prevalent	prevalent	JJ
cord-002530-ao7kenbx	17	10	herpesvirus	herpesvirus	NN
cord-002530-ao7kenbx	17	11	,	,	,
cord-002530-ao7kenbx	17	12	infecting	infect	VBG
cord-002530-ao7kenbx	17	13	30	30	CD
cord-002530-ao7kenbx	17	14	to	to	TO
cord-002530-ao7kenbx	17	15	100	100	CD
cord-002530-ao7kenbx	17	16	%	%	NN
cord-002530-ao7kenbx	17	17	of	of	IN
cord-002530-ao7kenbx	17	18	the	the	DT
cord-002530-ao7kenbx	17	19	global	global	JJ
cord-002530-ao7kenbx	17	20	population	population	NN
cord-002530-ao7kenbx	17	21	depending	depend	VBG
cord-002530-ao7kenbx	17	22	on	on	IN
cord-002530-ao7kenbx	17	23	the	the	DT
cord-002530-ao7kenbx	17	24	socio	socio	JJ
cord-002530-ao7kenbx	17	25	-	-	JJ
cord-002530-ao7kenbx	17	26	economic	economic	JJ
cord-002530-ao7kenbx	17	27	status	status	NN
cord-002530-ao7kenbx	17	28	.	.	.
cord-002530-ao7kenbx	18	1	Although	although	IN
cord-002530-ao7kenbx	18	2	normally	normally	RB
cord-002530-ao7kenbx	18	3	asymptomatic	asymptomatic	JJ
cord-002530-ao7kenbx	18	4	in	in	IN
cord-002530-ao7kenbx	18	5	healthy	healthy	JJ
cord-002530-ao7kenbx	18	6	individuals	individual	NNS
cord-002530-ao7kenbx	18	7	,	,	,
cord-002530-ao7kenbx	18	8	HCMV	HCMV	NNP
cord-002530-ao7kenbx	18	9	infection	infection	NN
cord-002530-ao7kenbx	18	10	is	be	VBZ
cord-002530-ao7kenbx	18	11	a	a	DT
cord-002530-ao7kenbx	18	12	significant	significant	JJ
cord-002530-ao7kenbx	18	13	cause	cause	NN
cord-002530-ao7kenbx	18	14	of	of	IN
cord-002530-ao7kenbx	18	15	morbidity	morbidity	NN
cord-002530-ao7kenbx	18	16	and	and	CC
cord-002530-ao7kenbx	18	17	mortality	mortality	NN
cord-002530-ao7kenbx	18	18	in	in	IN
cord-002530-ao7kenbx	18	19	immunocompromised	immunocompromised	JJ
cord-002530-ao7kenbx	18	20	populations	population	NNS
cord-002530-ao7kenbx	18	21	,	,	,
cord-002530-ao7kenbx	18	22	individuals	individual	NNS
cord-002530-ao7kenbx	18	23	with	with	IN
cord-002530-ao7kenbx	18	24	heart	heart	NN
cord-002530-ao7kenbx	18	25	disease	disease	NN
cord-002530-ao7kenbx	18	26	and	and	CC
cord-002530-ao7kenbx	18	27	recipients	recipient	NNS
cord-002530-ao7kenbx	18	28	of	of	IN
cord-002530-ao7kenbx	18	29	solid	solid	JJ
cord-002530-ao7kenbx	18	30	organ	organ	NN
cord-002530-ao7kenbx	18	31	and	and	CC
cord-002530-ao7kenbx	18	32	bone	bone	NN
cord-002530-ao7kenbx	18	33	marrow	marrow	NN
cord-002530-ao7kenbx	18	34	transplant	transplant	NN
cord-002530-ao7kenbx	18	35	.	.	.
cord-002530-ao7kenbx	19	1	HCMV	HCMV	NNP
cord-002530-ao7kenbx	19	2	is	be	VBZ
cord-002530-ao7kenbx	19	3	also	also	RB
cord-002530-ao7kenbx	19	4	the	the	DT
cord-002530-ao7kenbx	19	5	leading	leading	JJ
cord-002530-ao7kenbx	19	6	cause	cause	NN
cord-002530-ao7kenbx	19	7	of	of	IN
cord-002530-ao7kenbx	19	8	infectious	infectious	JJ
cord-002530-ao7kenbx	19	9	congenital	congenital	JJ
cord-002530-ao7kenbx	19	10	birth	birth	NN
cord-002530-ao7kenbx	19	11	defects	defect	NNS
cord-002530-ao7kenbx	19	12	[	[	-LRB-
cord-002530-ao7kenbx	19	13	1	1	CD
cord-002530-ao7kenbx	19	14	]	]	-RRB-
cord-002530-ao7kenbx	19	15	[	[	-LRB-
cord-002530-ao7kenbx	19	16	2	2	CD
cord-002530-ao7kenbx	19	17	]	]	-RRB-
cord-002530-ao7kenbx	19	18	[	[	-LRB-
cord-002530-ao7kenbx	19	19	3	3	CD
cord-002530-ao7kenbx	19	20	]	]	-RRB-
cord-002530-ao7kenbx	19	21	[	[	-LRB-
cord-002530-ao7kenbx	19	22	4	4	CD
cord-002530-ao7kenbx	19	23	]	]	-RRB-
cord-002530-ao7kenbx	19	24	[	[	-LRB-
cord-002530-ao7kenbx	19	25	5	5	CD
cord-002530-ao7kenbx	19	26	]	]	-RRB-
cord-002530-ao7kenbx	19	27	[	[	-LRB-
cord-002530-ao7kenbx	19	28	6	6	CD
cord-002530-ao7kenbx	19	29	]	]	-RRB-
cord-002530-ao7kenbx	19	30	[	[	-LRB-
cord-002530-ao7kenbx	19	31	7	7	CD
cord-002530-ao7kenbx	19	32	]	]	-RRB-
cord-002530-ao7kenbx	20	1	[	[	-LRB-
cord-002530-ao7kenbx	20	2	8	8	CD
cord-002530-ao7kenbx	20	3	]	]	-RRB-
cord-002530-ao7kenbx	20	4	[	[	-LRB-
cord-002530-ao7kenbx	20	5	9	9	CD
cord-002530-ao7kenbx	20	6	]	]	-RRB-
cord-002530-ao7kenbx	20	7	.	.	.
cord-002530-ao7kenbx	21	1	During	during	IN
cord-002530-ao7kenbx	21	2	infection	infection	NN
cord-002530-ao7kenbx	21	3	,	,	,
cord-002530-ao7kenbx	21	4	HCMV	HCMV	NNP
cord-002530-ao7kenbx	21	5	initiates	initiate	VBZ
cord-002530-ao7kenbx	21	6	a	a	DT
cord-002530-ao7kenbx	21	7	programmed	program	VBN
cord-002530-ao7kenbx	21	8	cascade	cascade	NN
cord-002530-ao7kenbx	21	9	of	of	IN
cord-002530-ao7kenbx	21	10	gene	gene	NN
cord-002530-ao7kenbx	21	11	expression	expression	NN
cord-002530-ao7kenbx	21	12	,	,	,
cord-002530-ao7kenbx	21	13	resulting	result	VBG
cord-002530-ao7kenbx	21	14	in	in	IN
cord-002530-ao7kenbx	21	15	production	production	NN
cord-002530-ao7kenbx	21	16	of	of	IN
cord-002530-ao7kenbx	21	17	infectious	infectious	JJ
cord-002530-ao7kenbx	21	18	virus	virus	NN
cord-002530-ao7kenbx	21	19	.	.	.
cord-002530-ao7kenbx	22	1	Two	two	CD
cord-002530-ao7kenbx	22	2	of	of	IN
cord-002530-ao7kenbx	22	3	the	the	DT
cord-002530-ao7kenbx	22	4	first	first	JJ
cord-002530-ao7kenbx	22	5	genes	gene	NNS
cord-002530-ao7kenbx	22	6	to	to	TO
cord-002530-ao7kenbx	22	7	be	be	VB
cord-002530-ao7kenbx	22	8	expressed	express	VBN
cord-002530-ao7kenbx	22	9	are	be	VBP
cord-002530-ao7kenbx	22	10	the	the	DT
cord-002530-ao7kenbx	22	11	major	major	JJ
cord-002530-ao7kenbx	22	12	immediate	immediate	JJ
cord-002530-ao7kenbx	22	13	early	early	JJ
cord-002530-ao7kenbx	22	14	(	(	-LRB-
cord-002530-ao7kenbx	22	15	MIE	MIE	NNP
cord-002530-ao7kenbx	22	16	)	)	-RRB-
cord-002530-ao7kenbx	22	17	genes	gene	NNS
cord-002530-ao7kenbx	22	18	IE1	ie1	NN
cord-002530-ao7kenbx	22	19	(	(	-LRB-
cord-002530-ao7kenbx	22	20	IE72	IE72	NNP
cord-002530-ao7kenbx	22	21	)	)	-RRB-
cord-002530-ao7kenbx	22	22	and	and	CC
cord-002530-ao7kenbx	22	23	IE2	ie2	NN
cord-002530-ao7kenbx	22	24	(	(	-LRB-
cord-002530-ao7kenbx	22	25	IE86	IE86	NNP
cord-002530-ao7kenbx	22	26	)	)	-RRB-
cord-002530-ao7kenbx	22	27	.	.	.
cord-002530-ao7kenbx	23	1	The	the	DT
cord-002530-ao7kenbx	23	2	MIE	MIE	NNP
cord-002530-ao7kenbx	23	3	proteins	protein	NNS
cord-002530-ao7kenbx	23	4	have	have	VBP
cord-002530-ao7kenbx	23	5	multiple	multiple	JJ
cord-002530-ao7kenbx	23	6	roles	role	NNS
cord-002530-ao7kenbx	23	7	during	during	IN
cord-002530-ao7kenbx	23	8	infection	infection	NN
cord-002530-ao7kenbx	23	9	including	include	VBG
cord-002530-ao7kenbx	23	10	transactivation	transactivation	NN
cord-002530-ao7kenbx	23	11	of	of	IN
cord-002530-ao7kenbx	23	12	viral	viral	JJ
cord-002530-ao7kenbx	23	13	genes	gene	NNS
cord-002530-ao7kenbx	23	14	,	,	,
cord-002530-ao7kenbx	23	15	which	which	WDT
cord-002530-ao7kenbx	23	16	drives	drive	VBZ
cord-002530-ao7kenbx	23	17	replication	replication	NN
cord-002530-ao7kenbx	23	18	and	and	CC
cord-002530-ao7kenbx	23	19	virus	virus	NN
cord-002530-ao7kenbx	23	20	production	production	NN
cord-002530-ao7kenbx	23	21	[	[	-LRB-
cord-002530-ao7kenbx	23	22	10	10	CD
cord-002530-ao7kenbx	23	23	]	]	-RRB-
cord-002530-ao7kenbx	24	1	[	[	-LRB-
cord-002530-ao7kenbx	24	2	11	11	CD
cord-002530-ao7kenbx	24	3	]	]	-RRB-
cord-002530-ao7kenbx	24	4	[	[	-LRB-
cord-002530-ao7kenbx	24	5	12	12	CD
cord-002530-ao7kenbx	24	6	]	]	-RRB-
cord-002530-ao7kenbx	24	7	.	.	.
cord-002530-ao7kenbx	25	1	Because	because	IN
cord-002530-ao7kenbx	25	2	of	of	IN
cord-002530-ao7kenbx	25	3	this	this	DT
cord-002530-ao7kenbx	25	4	,	,	,
cord-002530-ao7kenbx	25	5	they	-PRON-	PRP
cord-002530-ao7kenbx	25	6	are	be	VBP
cord-002530-ao7kenbx	25	7	thought	think	VBN
cord-002530-ao7kenbx	25	8	to	to	TO
cord-002530-ao7kenbx	25	9	play	play	VB
cord-002530-ao7kenbx	25	10	a	a	DT
cord-002530-ao7kenbx	25	11	pivotal	pivotal	JJ
cord-002530-ao7kenbx	25	12	role	role	NN
cord-002530-ao7kenbx	25	13	in	in	IN
cord-002530-ao7kenbx	25	14	controlling	control	VBG
cord-002530-ao7kenbx	25	15	the	the	DT
cord-002530-ao7kenbx	25	16	switch	switch	NN
cord-002530-ao7kenbx	25	17	between	between	IN
cord-002530-ao7kenbx	25	18	latent	latent	JJ
cord-002530-ao7kenbx	25	19	and	and	CC
cord-002530-ao7kenbx	25	20	productive	productive	JJ
cord-002530-ao7kenbx	25	21	infection	infection	NN
cord-002530-ao7kenbx	25	22	in	in	IN
cord-002530-ao7kenbx	25	23	HCMV	HCMV	NNP
cord-002530-ao7kenbx	25	24	[	[	-LRB-
cord-002530-ao7kenbx	25	25	13	13	CD
cord-002530-ao7kenbx	25	26	,	,	,
cord-002530-ao7kenbx	25	27	14	14	CD
cord-002530-ao7kenbx	25	28	]	]	-RRB-
cord-002530-ao7kenbx	25	29	.	.	.
cord-002530-ao7kenbx	26	1	While	while	IN
cord-002530-ao7kenbx	26	2	IE1	IE1	NNP
cord-002530-ao7kenbx	26	3	is	be	VBZ
cord-002530-ao7kenbx	26	4	required	require	VBN
cord-002530-ao7kenbx	26	5	for	for	IN
cord-002530-ao7kenbx	26	6	efficient	efficient	JJ
cord-002530-ao7kenbx	26	7	virus	virus	NN
cord-002530-ao7kenbx	26	8	replication	replication	NN
cord-002530-ao7kenbx	26	9	at	at	IN
cord-002530-ao7kenbx	26	10	low	low	JJ
cord-002530-ao7kenbx	26	11	multiplicity	multiplicity	NN
cord-002530-ao7kenbx	26	12	of	of	IN
cord-002530-ao7kenbx	26	13	infection	infection	NN
cord-002530-ao7kenbx	26	14	[	[	-LRB-
cord-002530-ao7kenbx	26	15	13	13	CD
cord-002530-ao7kenbx	26	16	,	,	,
cord-002530-ao7kenbx	26	17	14	14	CD
cord-002530-ao7kenbx	26	18	]	]	-RRB-
cord-002530-ao7kenbx	26	19	,	,	,
cord-002530-ao7kenbx	26	20	IE2	ie2	JJ
cord-002530-ao7kenbx	26	21	expression	expression	NN
cord-002530-ao7kenbx	26	22	is	be	VBZ
cord-002530-ao7kenbx	26	23	essential	essential	JJ
cord-002530-ao7kenbx	26	24	,	,	,
cord-002530-ao7kenbx	26	25	with	with	IN
cord-002530-ao7kenbx	26	26	deletion	deletion	NN
cord-002530-ao7kenbx	26	27	resulting	result	VBG
cord-002530-ao7kenbx	26	28	in	in	IN
cord-002530-ao7kenbx	26	29	non	non	JJ
cord-002530-ao7kenbx	26	30	-	-	JJ
cord-002530-ao7kenbx	26	31	viable	viable	JJ
cord-002530-ao7kenbx	26	32	virus	virus	NN
cord-002530-ao7kenbx	26	33	[	[	-LRB-
cord-002530-ao7kenbx	26	34	15	15	CD
cord-002530-ao7kenbx	26	35	]	]	-RRB-
cord-002530-ao7kenbx	26	36	.	.	.
cord-002530-ao7kenbx	27	1	IE1	ie1	NN
cord-002530-ao7kenbx	27	2	and	and	CC
cord-002530-ao7kenbx	27	3	IE2	IE2	NNP
cord-002530-ao7kenbx	27	4	are	be	VBP
cord-002530-ao7kenbx	27	5	generated	generate	VBN
cord-002530-ao7kenbx	27	6	from	from	IN
cord-002530-ao7kenbx	27	7	the	the	DT
cord-002530-ao7kenbx	27	8	same	same	JJ
cord-002530-ao7kenbx	27	9	primary	primary	JJ
cord-002530-ao7kenbx	27	10	transcript	transcript	NN
cord-002530-ao7kenbx	27	11	by	by	IN
cord-002530-ao7kenbx	27	12	differential	differential	JJ
cord-002530-ao7kenbx	27	13	splicing	splicing	NN
cord-002530-ao7kenbx	27	14	and	and	CC
cord-002530-ao7kenbx	27	15	alternative	alternative	JJ
cord-002530-ao7kenbx	27	16	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	27	17	[	[	-LRB-
cord-002530-ao7kenbx	27	18	10	10	CD
cord-002530-ao7kenbx	27	19	,	,	,
cord-002530-ao7kenbx	27	20	12	12	CD
cord-002530-ao7kenbx	27	21	,	,	,
cord-002530-ao7kenbx	27	22	16	16	CD
cord-002530-ao7kenbx	27	23	]	]	-RRB-
cord-002530-ao7kenbx	27	24	.	.	.
cord-002530-ao7kenbx	28	1	They	-PRON-	PRP
cord-002530-ao7kenbx	28	2	share	share	VBP
cord-002530-ao7kenbx	28	3	the	the	DT
cord-002530-ao7kenbx	28	4	first	first	JJ
cord-002530-ao7kenbx	28	5	three	three	CD
cord-002530-ao7kenbx	28	6	exons	exon	NNS
cord-002530-ao7kenbx	28	7	,	,	,
cord-002530-ao7kenbx	28	8	with	with	IN
cord-002530-ao7kenbx	28	9	splicing	splicing	NN
cord-002530-ao7kenbx	28	10	to	to	IN
cord-002530-ao7kenbx	28	11	the	the	DT
cord-002530-ao7kenbx	28	12	fourth	fourth	JJ
cord-002530-ao7kenbx	28	13	or	or	CC
cord-002530-ao7kenbx	28	14	fifth	fifth	JJ
cord-002530-ao7kenbx	28	15	exon	exon	NN
cord-002530-ao7kenbx	28	16	determining	determine	VBG
cord-002530-ao7kenbx	28	17	expression	expression	NN
cord-002530-ao7kenbx	28	18	of	of	IN
cord-002530-ao7kenbx	28	19	IE1	ie1	NN
cord-002530-ao7kenbx	28	20	or	or	CC
cord-002530-ao7kenbx	28	21	IE2	IE2	NNP
cord-002530-ao7kenbx	28	22	transcript	transcript	NN
cord-002530-ao7kenbx	28	23	,	,	,
cord-002530-ao7kenbx	28	24	respectively	respectively	RB
cord-002530-ao7kenbx	28	25	(	(	-LRB-
cord-002530-ao7kenbx	28	26	Fig	Fig	NNP
cord-002530-ao7kenbx	28	27	1	1	CD
cord-002530-ao7kenbx	28	28	)	)	-RRB-
cord-002530-ao7kenbx	28	29	.	.	.
cord-002530-ao7kenbx	29	1	Independent	independent	JJ
cord-002530-ao7kenbx	29	2	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	29	3	signals	signal	NNS
cord-002530-ao7kenbx	29	4	exist	exist	VBP
cord-002530-ao7kenbx	29	5	downstream	downstream	RB
cord-002530-ao7kenbx	29	6	of	of	IN
cord-002530-ao7kenbx	29	7	both	both	DT
cord-002530-ao7kenbx	29	8	exon	exon	NN
cord-002530-ao7kenbx	29	9	four	four	CD
cord-002530-ao7kenbx	29	10	and	and	CC
cord-002530-ao7kenbx	29	11	exon	exon	VBD
cord-002530-ao7kenbx	29	12	five	five	CD
cord-002530-ao7kenbx	29	13	.	.	.
cord-002530-ao7kenbx	30	1	Such	such	JJ
cord-002530-ao7kenbx	30	2	genomic	genomic	JJ
cord-002530-ao7kenbx	30	3	arrangements	arrangement	NNS
cord-002530-ao7kenbx	30	4	,	,	,
cord-002530-ao7kenbx	30	5	that	that	WDT
cord-002530-ao7kenbx	30	6	require	require	VBP
cord-002530-ao7kenbx	30	7	terminal	terminal	NN
cord-002530-ao7kenbx	30	8	exon	exon	NN
cord-002530-ao7kenbx	30	9	skipping	skip	VBG
cord-002530-ao7kenbx	30	10	,	,	,
cord-002530-ao7kenbx	30	11	are	be	VBP
cord-002530-ao7kenbx	30	12	considered	consider	VBN
cord-002530-ao7kenbx	30	13	relatively	relatively	RB
cord-002530-ao7kenbx	30	14	unusual	unusual	JJ
cord-002530-ao7kenbx	30	15	in	in	IN
cord-002530-ao7kenbx	30	16	the	the	DT
cord-002530-ao7kenbx	30	17	host	host	NN
cord-002530-ao7kenbx	30	18	cell	cell	NN
cord-002530-ao7kenbx	30	19	,	,	,
cord-002530-ao7kenbx	30	20	with	with	IN
cord-002530-ao7kenbx	30	21	specific	specific	JJ
cord-002530-ao7kenbx	30	22	factors	factor	NNS
cord-002530-ao7kenbx	30	23	and	and	CC
cord-002530-ao7kenbx	30	24	mechanisms	mechanism	NNS
cord-002530-ao7kenbx	30	25	involved	involve	VBN
cord-002530-ao7kenbx	30	26	in	in	IN
cord-002530-ao7kenbx	30	27	regulating	regulate	VBG
cord-002530-ao7kenbx	30	28	the	the	DT
cord-002530-ao7kenbx	30	29	process	process	NN
cord-002530-ao7kenbx	30	30	not	not	RB
cord-002530-ao7kenbx	30	31	fully	fully	RB
cord-002530-ao7kenbx	30	32	understood	understand	VBN
cord-002530-ao7kenbx	30	33	[	[	-LRB-
cord-002530-ao7kenbx	30	34	17	17	CD
cord-002530-ao7kenbx	30	35	]	]	-RRB-
cord-002530-ao7kenbx	30	36	.	.	.
cord-002530-ao7kenbx	31	1	Valosin	Valosin	NNP
cord-002530-ao7kenbx	31	2	containing	contain	VBG
cord-002530-ao7kenbx	31	3	protein	protein	NN
cord-002530-ao7kenbx	31	4	(	(	-LRB-
cord-002530-ao7kenbx	31	5	VCP	VCP	NNP
cord-002530-ao7kenbx	31	6	)	)	-RRB-
cord-002530-ao7kenbx	31	7	belongs	belong	VBZ
cord-002530-ao7kenbx	31	8	to	to	IN
cord-002530-ao7kenbx	31	9	the	the	DT
cord-002530-ao7kenbx	31	10	hexameric	hexameric	JJ
cord-002530-ao7kenbx	31	11	AAA	AAA	NNP
cord-002530-ao7kenbx	31	12	ATPase	ATPase	NNP
cord-002530-ao7kenbx	31	13	family	family	NN
cord-002530-ao7kenbx	31	14	and	and	CC
cord-002530-ao7kenbx	31	15	plays	play	VBZ
cord-002530-ao7kenbx	31	16	a	a	DT
cord-002530-ao7kenbx	31	17	pivotal	pivotal	JJ
cord-002530-ao7kenbx	31	18	role	role	NN
cord-002530-ao7kenbx	31	19	in	in	IN
cord-002530-ao7kenbx	31	20	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	31	21	mediated	mediate	VBN
cord-002530-ao7kenbx	31	22	signaling	signal	VBG
cord-002530-ao7kenbx	31	23	through	through	IN
cord-002530-ao7kenbx	31	24	remodeling	remodel	VBG
cord-002530-ao7kenbx	31	25	target	target	NN
cord-002530-ao7kenbx	31	26	proteins	protein	NNS
cord-002530-ao7kenbx	31	27	,	,	,
cord-002530-ao7kenbx	31	28	often	often	RB
cord-002530-ao7kenbx	31	29	leading	lead	VBG
cord-002530-ao7kenbx	31	30	to	to	IN
cord-002530-ao7kenbx	31	31	proteosomal	proteosomal	FW
cord-002530-ao7kenbx	31	32	degradation	degradation	NN
cord-002530-ao7kenbx	31	33	[	[	-LRB-
cord-002530-ao7kenbx	31	34	18	18	CD
cord-002530-ao7kenbx	31	35	]	]	-RRB-
cord-002530-ao7kenbx	31	36	.	.	.
cord-002530-ao7kenbx	32	1	VCP	VCP	NNP
cord-002530-ao7kenbx	32	2	contains	contain	VBZ
cord-002530-ao7kenbx	32	3	two	two	CD
cord-002530-ao7kenbx	32	4	ATPase	ATPase	NNP
cord-002530-ao7kenbx	32	5	domains	domain	NNS
cord-002530-ao7kenbx	32	6	,	,	,
cord-002530-ao7kenbx	32	7	which	which	WDT
cord-002530-ao7kenbx	32	8	hydrolyze	hydrolyze	VBP
cord-002530-ao7kenbx	32	9	ATP	ATP	NNP
cord-002530-ao7kenbx	32	10	to	to	TO
cord-002530-ao7kenbx	32	11	generate	generate	VB
cord-002530-ao7kenbx	32	12	the	the	DT
cord-002530-ao7kenbx	32	13	energy	energy	NN
cord-002530-ao7kenbx	32	14	required	require	VBN
cord-002530-ao7kenbx	32	15	to	to	TO
cord-002530-ao7kenbx	32	16	remodel	remodel	VB
cord-002530-ao7kenbx	32	17	or	or	CC
cord-002530-ao7kenbx	32	18	unfold	unfold	VB
cord-002530-ao7kenbx	32	19	target	target	NN
cord-002530-ao7kenbx	32	20	proteins	protein	NNS
cord-002530-ao7kenbx	32	21	.	.	.
cord-002530-ao7kenbx	33	1	Through	through	IN
cord-002530-ao7kenbx	33	2	this	this	DT
cord-002530-ao7kenbx	33	3	action	action	NN
cord-002530-ao7kenbx	33	4	,	,	,
cord-002530-ao7kenbx	33	5	VCP	VCP	NNP
cord-002530-ao7kenbx	33	6	is	be	VBZ
cord-002530-ao7kenbx	33	7	able	able	JJ
cord-002530-ao7kenbx	33	8	to	to	TO
cord-002530-ao7kenbx	33	9	segregate	segregate	VB
cord-002530-ao7kenbx	33	10	target	target	NN
cord-002530-ao7kenbx	33	11	proteins	protein	NNS
cord-002530-ao7kenbx	33	12	from	from	IN
cord-002530-ao7kenbx	33	13	associated	associated	JJ
cord-002530-ao7kenbx	33	14	cellular	cellular	JJ
cord-002530-ao7kenbx	33	15	membranes	membrane	NNS
cord-002530-ao7kenbx	33	16	or	or	CC
cord-002530-ao7kenbx	33	17	larger	large	JJR
cord-002530-ao7kenbx	33	18	protein	protein	NN
cord-002530-ao7kenbx	33	19	complexes	complex	NNS
cord-002530-ao7kenbx	33	20	.	.	.
cord-002530-ao7kenbx	34	1	Once	once	RB
cord-002530-ao7kenbx	34	2	segregated	segregate	VBN
cord-002530-ao7kenbx	34	3	,	,	,
cord-002530-ao7kenbx	34	4	the	the	DT
cord-002530-ao7kenbx	34	5	target	target	NN
cord-002530-ao7kenbx	34	6	protein	protein	NN
cord-002530-ao7kenbx	34	7	is	be	VBZ
cord-002530-ao7kenbx	34	8	relocalised	relocalise	VBN
cord-002530-ao7kenbx	34	9	or	or	CC
cord-002530-ao7kenbx	34	10	degraded	degrade	VBN
cord-002530-ao7kenbx	34	11	via	via	IN
cord-002530-ao7kenbx	34	12	the	the	DT
cord-002530-ao7kenbx	34	13	proteosomal	proteosomal	JJ
cord-002530-ao7kenbx	34	14	complex	complex	NN
cord-002530-ao7kenbx	34	15	.	.	.
cord-002530-ao7kenbx	35	1	VCP	VCP	NNP
cord-002530-ao7kenbx	35	2	can	can	MD
cord-002530-ao7kenbx	35	3	also	also	RB
cord-002530-ao7kenbx	35	4	affect	affect	VB
cord-002530-ao7kenbx	35	5	which	which	WDT
cord-002530-ao7kenbx	35	6	proteins	protein	NNS
cord-002530-ao7kenbx	35	7	are	be	VBP
cord-002530-ao7kenbx	35	8	modified	modify	VBN
cord-002530-ao7kenbx	35	9	through	through	IN
cord-002530-ao7kenbx	35	10	its	-PRON-	PRP$
cord-002530-ao7kenbx	35	11	interaction	interaction	NN
cord-002530-ao7kenbx	35	12	with	with	IN
cord-002530-ao7kenbx	35	13	multiple	multiple	JJ
cord-002530-ao7kenbx	35	14	ubiquitin	ubiquitin	JJ
cord-002530-ao7kenbx	35	15	regulatory	regulatory	JJ
cord-002530-ao7kenbx	35	16	co	co	NNS
cord-002530-ao7kenbx	35	17	-	-	NNS
cord-002530-ao7kenbx	35	18	factors	factor	NNS
cord-002530-ao7kenbx	35	19	,	,	,
cord-002530-ao7kenbx	35	20	making	make	VBG
cord-002530-ao7kenbx	35	21	VCP	VCP	NNP
cord-002530-ao7kenbx	35	22	a	a	DT
cord-002530-ao7kenbx	35	23	central	central	JJ
cord-002530-ao7kenbx	35	24	signalling	signal	VBG
cord-002530-ao7kenbx	35	25	hub	hub	NN
cord-002530-ao7kenbx	35	26	for	for	IN
cord-002530-ao7kenbx	35	27	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	35	28	mediated	mediate	VBN
cord-002530-ao7kenbx	35	29	regulation	regulation	NN
cord-002530-ao7kenbx	35	30	.	.	.
cord-002530-ao7kenbx	36	1	In	in	IN
cord-002530-ao7kenbx	36	2	addition	addition	NN
cord-002530-ao7kenbx	36	3	to	to	IN
cord-002530-ao7kenbx	36	4	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	36	5	,	,	,
cord-002530-ao7kenbx	36	6	VCP	VCP	NNP
cord-002530-ao7kenbx	36	7	has	have	VBZ
cord-002530-ao7kenbx	36	8	been	be	VBN
cord-002530-ao7kenbx	36	9	linked	link	VBN
cord-002530-ao7kenbx	36	10	to	to	IN
cord-002530-ao7kenbx	36	11	other	other	JJ
cord-002530-ao7kenbx	36	12	post	post	JJ
cord-002530-ao7kenbx	36	13	-	-	JJ
cord-002530-ao7kenbx	36	14	translational	translational	JJ
cord-002530-ao7kenbx	36	15	modifiers	modifier	NNS
cord-002530-ao7kenbx	36	16	such	such	JJ
cord-002530-ao7kenbx	36	17	as	as	IN
cord-002530-ao7kenbx	36	18	SUMO	SUMO	NNP
cord-002530-ao7kenbx	36	19	and	and	CC
cord-002530-ao7kenbx	36	20	Nedd8	nedd8	JJ
cord-002530-ao7kenbx	36	21	[	[	-LRB-
cord-002530-ao7kenbx	36	22	19	19	CD
cord-002530-ao7kenbx	36	23	,	,	,
cord-002530-ao7kenbx	36	24	20	20	CD
cord-002530-ao7kenbx	36	25	]	]	-RRB-
cord-002530-ao7kenbx	36	26	.	.	.
cord-002530-ao7kenbx	37	1	As	as	IN
cord-002530-ao7kenbx	37	2	such	such	JJ
cord-002530-ao7kenbx	37	3	it	-PRON-	PRP
cord-002530-ao7kenbx	37	4	is	be	VBZ
cord-002530-ao7kenbx	37	5	linked	link	VBN
cord-002530-ao7kenbx	37	6	to	to	IN
cord-002530-ao7kenbx	37	7	a	a	DT
cord-002530-ao7kenbx	37	8	wide	wide	JJ
cord-002530-ao7kenbx	37	9	range	range	NN
cord-002530-ao7kenbx	37	10	of	of	IN
cord-002530-ao7kenbx	37	11	biological	biological	JJ
cord-002530-ao7kenbx	37	12	functions	function	NNS
cord-002530-ao7kenbx	37	13	,	,	,
cord-002530-ao7kenbx	37	14	including	include	VBG
cord-002530-ao7kenbx	37	15	protein	protein	NN
cord-002530-ao7kenbx	37	16	quality	quality	NN
cord-002530-ao7kenbx	37	17	control	control	NN
cord-002530-ao7kenbx	37	18	,	,	,
cord-002530-ao7kenbx	37	19	autophagy	autophagy	NN
cord-002530-ao7kenbx	37	20	,	,	,
cord-002530-ao7kenbx	37	21	chromatin	chromatin	NN
cord-002530-ao7kenbx	37	22	remodeling	remodeling	NN
cord-002530-ao7kenbx	37	23	,	,	,
cord-002530-ao7kenbx	37	24	DNA	dna	NN
cord-002530-ao7kenbx	37	25	damage	damage	NN
cord-002530-ao7kenbx	37	26	response	response	NN
cord-002530-ao7kenbx	37	27	and	and	CC
cord-002530-ao7kenbx	37	28	more	more	RBR
cord-002530-ao7kenbx	37	29	recently	recently	RB
cord-002530-ao7kenbx	37	30	RNA	RNA	NNP
cord-002530-ao7kenbx	37	31	processing	processing	NN
cord-002530-ao7kenbx	37	32	[	[	-LRB-
cord-002530-ao7kenbx	37	33	21	21	CD
cord-002530-ao7kenbx	37	34	]	]	-RRB-
cord-002530-ao7kenbx	37	35	.	.	.
cord-002530-ao7kenbx	38	1	Functionally	functionally	RB
cord-002530-ao7kenbx	38	2	,	,	,
cord-002530-ao7kenbx	38	3	VCP	VCP	NNP
cord-002530-ao7kenbx	38	4	plays	play	VBZ
cord-002530-ao7kenbx	38	5	a	a	DT
cord-002530-ao7kenbx	38	6	central	central	JJ
cord-002530-ao7kenbx	38	7	role	role	NN
cord-002530-ao7kenbx	38	8	in	in	IN
cord-002530-ao7kenbx	38	9	protein	protein	NN
cord-002530-ao7kenbx	38	10	homeostasis	homeostasis	NN
cord-002530-ao7kenbx	38	11	by	by	IN
cord-002530-ao7kenbx	38	12	facilitating	facilitate	VBG
cord-002530-ao7kenbx	38	13	proteosomal	proteosomal	JJ
cord-002530-ao7kenbx	38	14	degradation	degradation	NN
cord-002530-ao7kenbx	38	15	of	of	IN
cord-002530-ao7kenbx	38	16	misfolded	misfolded	JJ
cord-002530-ao7kenbx	38	17	or	or	CC
cord-002530-ao7kenbx	38	18	damaged	damage	VBN
cord-002530-ao7kenbx	38	19	proteins	protein	NNS
cord-002530-ao7kenbx	38	20	as	as	IN
cord-002530-ao7kenbx	38	21	part	part	NN
cord-002530-ao7kenbx	38	22	of	of	IN
cord-002530-ao7kenbx	38	23	the	the	DT
cord-002530-ao7kenbx	38	24	endoplasmic	endoplasmic	NN
cord-002530-ao7kenbx	38	25	reticulum	reticulum	NN
cord-002530-ao7kenbx	38	26	associated	associate	VBD
cord-002530-ao7kenbx	38	27	degradation	degradation	NN
cord-002530-ao7kenbx	38	28	pathway	pathway	NN
cord-002530-ao7kenbx	38	29	(	(	-LRB-
cord-002530-ao7kenbx	38	30	ERAD	ERAD	NNP
cord-002530-ao7kenbx	38	31	)	)	-RRB-
cord-002530-ao7kenbx	38	32	.	.	.
cord-002530-ao7kenbx	39	1	In	in	IN
cord-002530-ao7kenbx	39	2	addition	addition	NN
cord-002530-ao7kenbx	39	3	to	to	IN
cord-002530-ao7kenbx	39	4	its	-PRON-	PRP$
cord-002530-ao7kenbx	39	5	role	role	NN
cord-002530-ao7kenbx	39	6	in	in	IN
cord-002530-ao7kenbx	39	7	protein	protein	NN
cord-002530-ao7kenbx	39	8	degradation	degradation	NN
cord-002530-ao7kenbx	39	9	,	,	,
cord-002530-ao7kenbx	39	10	VCP	VCP	NNP
cord-002530-ao7kenbx	39	11	has	have	VBZ
cord-002530-ao7kenbx	39	12	been	be	VBN
cord-002530-ao7kenbx	39	13	linked	link	VBN
cord-002530-ao7kenbx	39	14	to	to	IN
cord-002530-ao7kenbx	39	15	non	non	JJ
cord-002530-ao7kenbx	39	16	-	-	JJ
cord-002530-ao7kenbx	39	17	degradative	degradative	JJ
cord-002530-ao7kenbx	39	18	functions	function	NNS
cord-002530-ao7kenbx	39	19	involving	involve	VBG
cord-002530-ao7kenbx	39	20	removal	removal	NN
cord-002530-ao7kenbx	39	21	and	and	CC
cord-002530-ao7kenbx	39	22	relocation	relocation	NN
cord-002530-ao7kenbx	39	23	of	of	IN
cord-002530-ao7kenbx	39	24	proteins	protein	NNS
cord-002530-ao7kenbx	39	25	from	from	IN
cord-002530-ao7kenbx	39	26	membranes	membrane	NNS
cord-002530-ao7kenbx	39	27	and	and	CC
cord-002530-ao7kenbx	39	28	protein	protein	NN
cord-002530-ao7kenbx	39	29	complexes	complex	NNS
cord-002530-ao7kenbx	39	30	.	.	.
cord-002530-ao7kenbx	40	1	Examples	example	NNS
cord-002530-ao7kenbx	40	2	include	include	VBP
cord-002530-ao7kenbx	40	3	removal	removal	NN
cord-002530-ao7kenbx	40	4	of	of	IN
cord-002530-ao7kenbx	40	5	Aurora	Aurora	NNP
cord-002530-ao7kenbx	40	6	B	B	NNP
cord-002530-ao7kenbx	40	7	protein	protein	NN
cord-002530-ao7kenbx	40	8	from	from	IN
cord-002530-ao7kenbx	40	9	mitotic	mitotic	JJ
cord-002530-ao7kenbx	40	10	chromosomes	chromosome	NNS
cord-002530-ao7kenbx	40	11	,	,	,
cord-002530-ao7kenbx	40	12	removal	removal	NN
cord-002530-ao7kenbx	40	13	of	of	IN
cord-002530-ao7kenbx	40	14	transcription	transcription	NN
cord-002530-ao7kenbx	40	15	factors	factor	NNS
cord-002530-ao7kenbx	40	16	from	from	IN
cord-002530-ao7kenbx	40	17	chromatin	chromatin	NN
cord-002530-ao7kenbx	40	18	and	and	CC
cord-002530-ao7kenbx	40	19	disassembly	disassembly	NN
cord-002530-ao7kenbx	40	20	of	of	IN
cord-002530-ao7kenbx	40	21	RNP	RNP	NNP
cord-002530-ao7kenbx	40	22	complexes	complex	NNS
cord-002530-ao7kenbx	40	23	[	[	-LRB-
cord-002530-ao7kenbx	40	24	22	22	CD
cord-002530-ao7kenbx	40	25	,	,	,
cord-002530-ao7kenbx	40	26	23	23	CD
cord-002530-ao7kenbx	40	27	]	]	-RRB-
cord-002530-ao7kenbx	40	28	.	.	.
cord-002530-ao7kenbx	41	1	It	-PRON-	PRP
cord-002530-ao7kenbx	41	2	has	have	VBZ
cord-002530-ao7kenbx	41	3	also	also	RB
cord-002530-ao7kenbx	41	4	been	be	VBN
cord-002530-ao7kenbx	41	5	linked	link	VBN
cord-002530-ao7kenbx	41	6	to	to	IN
cord-002530-ao7kenbx	41	7	a	a	DT
cord-002530-ao7kenbx	41	8	number	number	NN
cord-002530-ao7kenbx	41	9	of	of	IN
cord-002530-ao7kenbx	41	10	functional	functional	JJ
cord-002530-ao7kenbx	41	11	roles	role	NNS
cord-002530-ao7kenbx	41	12	in	in	IN
cord-002530-ao7kenbx	41	13	virus	virus	NN
cord-002530-ao7kenbx	41	14	replication	replication	NN
cord-002530-ao7kenbx	41	15	including	include	VBG
cord-002530-ao7kenbx	41	16	entry	entry	NN
cord-002530-ao7kenbx	41	17	of	of	IN
cord-002530-ao7kenbx	41	18	Sindbis	Sindbis	NNP
cord-002530-ao7kenbx	41	19	virus	virus	NN
cord-002530-ao7kenbx	41	20	and	and	CC
cord-002530-ao7kenbx	41	21	replication	replication	NN
cord-002530-ao7kenbx	41	22	of	of	IN
cord-002530-ao7kenbx	41	23	poliovirus	poliovirus	NN
cord-002530-ao7kenbx	41	24	[	[	-LRB-
cord-002530-ao7kenbx	41	25	24	24	CD
cord-002530-ao7kenbx	41	26	]	]	-RRB-
cord-002530-ao7kenbx	41	27	[	[	-LRB-
cord-002530-ao7kenbx	41	28	25	25	CD
cord-002530-ao7kenbx	41	29	]	]	-RRB-
cord-002530-ao7kenbx	41	30	[	[	-LRB-
cord-002530-ao7kenbx	41	31	26	26	CD
cord-002530-ao7kenbx	41	32	]	]	-RRB-
cord-002530-ao7kenbx	41	33	.	.	.
cord-002530-ao7kenbx	42	1	While	while	IN
cord-002530-ao7kenbx	42	2	VCP	VCP	NNP
cord-002530-ao7kenbx	42	3	plays	play	VBZ
cord-002530-ao7kenbx	42	4	a	a	DT
cord-002530-ao7kenbx	42	5	role	role	NN
cord-002530-ao7kenbx	42	6	in	in	IN
cord-002530-ao7kenbx	42	7	US11-specific	us11-specific	JJ
cord-002530-ao7kenbx	42	8	degradation	degradation	NN
cord-002530-ao7kenbx	42	9	of	of	IN
cord-002530-ao7kenbx	42	10	MHC	MHC	NNP
cord-002530-ao7kenbx	42	11	class	class	NN
cord-002530-ao7kenbx	42	12	I	-PRON-	PRP
cord-002530-ao7kenbx	42	13	protein	protein	VBP
cord-002530-ao7kenbx	42	14	during	during	IN
cord-002530-ao7kenbx	42	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	42	16	infection	infection	NN
cord-002530-ao7kenbx	42	17	[	[	-LRB-
cord-002530-ao7kenbx	42	18	27	27	CD
cord-002530-ao7kenbx	42	19	]	]	-RRB-
cord-002530-ao7kenbx	42	20	a	a	DT
cord-002530-ao7kenbx	42	21	direct	direct	JJ
cord-002530-ao7kenbx	42	22	role	role	NN
cord-002530-ao7kenbx	42	23	for	for	IN
cord-002530-ao7kenbx	42	24	VCP	VCP	NNP
cord-002530-ao7kenbx	42	25	in	in	IN
cord-002530-ao7kenbx	42	26	the	the	DT
cord-002530-ao7kenbx	42	27	replication	replication	NN
cord-002530-ao7kenbx	42	28	of	of	IN
cord-002530-ao7kenbx	42	29	HCMV	HCMV	NNP
cord-002530-ao7kenbx	42	30	has	have	VBZ
cord-002530-ao7kenbx	42	31	not	not	RB
cord-002530-ao7kenbx	42	32	previously	previously	RB
cord-002530-ao7kenbx	42	33	been	be	VBN
cord-002530-ao7kenbx	42	34	reported	report	VBN
cord-002530-ao7kenbx	42	35	.	.	.
cord-002530-ao7kenbx	43	1	Using	use	VBG
cord-002530-ao7kenbx	43	2	a	a	DT
cord-002530-ao7kenbx	43	3	focused	focused	JJ
cord-002530-ao7kenbx	43	4	siRNA	siRNA	NNP
cord-002530-ao7kenbx	43	5	screen	screen	NN
cord-002530-ao7kenbx	43	6	,	,	,
cord-002530-ao7kenbx	43	7	we	-PRON-	PRP
cord-002530-ao7kenbx	43	8	identified	identify	VBD
cord-002530-ao7kenbx	43	9	VCP	VCP	NNP
cord-002530-ao7kenbx	43	10	as	as	IN
cord-002530-ao7kenbx	43	11	an	an	DT
cord-002530-ao7kenbx	43	12	essential	essential	JJ
cord-002530-ao7kenbx	43	13	factor	factor	NN
cord-002530-ao7kenbx	43	14	for	for	IN
cord-002530-ao7kenbx	43	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	43	16	replication	replication	NN
cord-002530-ao7kenbx	43	17	.	.	.
cord-002530-ao7kenbx	44	1	We	-PRON-	PRP
cord-002530-ao7kenbx	44	2	show	show	VBP
cord-002530-ao7kenbx	44	3	that	that	IN
cord-002530-ao7kenbx	44	4	VCP	VCP	NNP
cord-002530-ao7kenbx	44	5	is	be	VBZ
cord-002530-ao7kenbx	44	6	essential	essential	JJ
cord-002530-ao7kenbx	44	7	for	for	IN
cord-002530-ao7kenbx	44	8	the	the	DT
cord-002530-ao7kenbx	44	9	onset	onset	NN
cord-002530-ao7kenbx	44	10	of	of	IN
cord-002530-ao7kenbx	44	11	virus	virus	NN
cord-002530-ao7kenbx	44	12	replication	replication	NN
cord-002530-ao7kenbx	44	13	and	and	CC
cord-002530-ao7kenbx	44	14	knockdown	knockdown	NN
cord-002530-ao7kenbx	44	15	of	of	IN
cord-002530-ao7kenbx	44	16	VCP	VCP	NNP
cord-002530-ao7kenbx	44	17	results	result	NNS
cord-002530-ao7kenbx	44	18	in	in	IN
cord-002530-ao7kenbx	44	19	changes	change	NNS
cord-002530-ao7kenbx	44	20	in	in	IN
cord-002530-ao7kenbx	44	21	alternative	alternative	JJ
cord-002530-ao7kenbx	44	22	splicing	splicing	NN
cord-002530-ao7kenbx	44	23	of	of	IN
cord-002530-ao7kenbx	44	24	the	the	DT
cord-002530-ao7kenbx	44	25	MIE	MIE	NNP
cord-002530-ao7kenbx	44	26	transcripts	transcript	NNS
cord-002530-ao7kenbx	44	27	,	,	,
cord-002530-ao7kenbx	44	28	loss	loss	NN
cord-002530-ao7kenbx	44	29	of	of	IN
cord-002530-ao7kenbx	44	30	IE2	ie2	JJ
cord-002530-ao7kenbx	44	31	expression	expression	NN
cord-002530-ao7kenbx	44	32	and	and	CC
cord-002530-ao7kenbx	44	33	ultimately	ultimately	RB
cord-002530-ao7kenbx	44	34	failure	failure	NN
cord-002530-ao7kenbx	44	35	in	in	IN
cord-002530-ao7kenbx	44	36	virus	virus	NN
cord-002530-ao7kenbx	44	37	replication	replication	NN
cord-002530-ao7kenbx	44	38	.	.	.
cord-002530-ao7kenbx	45	1	Previously	previously	RB
cord-002530-ao7kenbx	45	2	,	,	,
cord-002530-ao7kenbx	45	3	we	-PRON-	PRP
cord-002530-ao7kenbx	45	4	identified	identify	VBD
cord-002530-ao7kenbx	45	5	the	the	DT
cord-002530-ao7kenbx	45	6	host	host	NN
cord-002530-ao7kenbx	45	7	gene	gene	NN
cord-002530-ao7kenbx	45	8	ATP6V0C	atp6v0c	NN
cord-002530-ao7kenbx	45	9	as	as	IN
cord-002530-ao7kenbx	45	10	a	a	DT
cord-002530-ao7kenbx	45	11	critical	critical	JJ
cord-002530-ao7kenbx	45	12	factor	factor	NN
cord-002530-ao7kenbx	45	13	in	in	IN
cord-002530-ao7kenbx	45	14	HCMV	HCMV	NNP
cord-002530-ao7kenbx	45	15	virus	virus	NN
cord-002530-ao7kenbx	45	16	production	production	NN
cord-002530-ao7kenbx	45	17	[	[	-LRB-
cord-002530-ao7kenbx	45	18	28	28	CD
cord-002530-ao7kenbx	45	19	]	]	-RRB-
cord-002530-ao7kenbx	45	20	.	.	.
cord-002530-ao7kenbx	46	1	ATP6V0C	atp6v0c	LS
cord-002530-ao7kenbx	46	2	is	be	VBZ
cord-002530-ao7kenbx	46	3	a	a	DT
cord-002530-ao7kenbx	46	4	component	component	NN
cord-002530-ao7kenbx	46	5	of	of	IN
cord-002530-ao7kenbx	46	6	the	the	DT
cord-002530-ao7kenbx	46	7	vacuolar	vacuolar	NNP
cord-002530-ao7kenbx	46	8	ATPase	ATPase	NNP
cord-002530-ao7kenbx	46	9	,	,	,
cord-002530-ao7kenbx	46	10	and	and	CC
cord-002530-ao7kenbx	46	11	among	among	IN
cord-002530-ao7kenbx	46	12	other	other	JJ
cord-002530-ao7kenbx	46	13	functions	function	NNS
cord-002530-ao7kenbx	46	14	,	,	,
cord-002530-ao7kenbx	46	15	is	be	VBZ
cord-002530-ao7kenbx	46	16	involved	involve	VBN
cord-002530-ao7kenbx	46	17	in	in	IN
cord-002530-ao7kenbx	46	18	membrane	membrane	NN
cord-002530-ao7kenbx	46	19	organization	organization	NN
cord-002530-ao7kenbx	46	20	[	[	-LRB-
cord-002530-ao7kenbx	46	21	29	29	CD
cord-002530-ao7kenbx	46	22	]	]	-RRB-
cord-002530-ao7kenbx	46	23	.	.	.
cord-002530-ao7kenbx	47	1	To	to	TO
cord-002530-ao7kenbx	47	2	identify	identify	VB
cord-002530-ao7kenbx	47	3	additional	additional	JJ
cord-002530-ao7kenbx	47	4	host	host	NN
cord-002530-ao7kenbx	47	5	membrane	membrane	NN
cord-002530-ao7kenbx	47	6	organization	organization	NN
cord-002530-ao7kenbx	47	7	factors	factor	NNS
cord-002530-ao7kenbx	47	8	involved	involve	VBN
cord-002530-ao7kenbx	47	9	in	in	IN
cord-002530-ao7kenbx	47	10	HCMV	HCMV	NNP
cord-002530-ao7kenbx	47	11	replication	replication	NN
cord-002530-ao7kenbx	47	12	we	-PRON-	PRP
cord-002530-ao7kenbx	47	13	performed	perform	VBD
cord-002530-ao7kenbx	47	14	a	a	DT
cord-002530-ao7kenbx	47	15	focused	focused	JJ
cord-002530-ao7kenbx	47	16	siRNA	siRNA	NNP
cord-002530-ao7kenbx	47	17	screen	screen	NN
cord-002530-ao7kenbx	47	18	against	against	IN
cord-002530-ao7kenbx	47	19	160	160	CD
cord-002530-ao7kenbx	47	20	host	host	NN
cord-002530-ao7kenbx	47	21	genes	gene	NNS
cord-002530-ao7kenbx	47	22	involved	involve	VBN
cord-002530-ao7kenbx	47	23	in	in	IN
cord-002530-ao7kenbx	47	24	membrane	membrane	NN
cord-002530-ao7kenbx	47	25	organization	organization	NN
cord-002530-ao7kenbx	47	26	using	use	VBG
cord-002530-ao7kenbx	47	27	pools	pool	NNS
cord-002530-ao7kenbx	47	28	of	of	IN
cord-002530-ao7kenbx	47	29	four	four	CD
cord-002530-ao7kenbx	47	30	siRNAs	sirna	NNS
cord-002530-ao7kenbx	47	31	against	against	IN
cord-002530-ao7kenbx	47	32	each	each	DT
cord-002530-ao7kenbx	47	33	target	target	NN
cord-002530-ao7kenbx	47	34	.	.	.
cord-002530-ao7kenbx	48	1	Primary	primary	JJ
cord-002530-ao7kenbx	48	2	human	human	JJ
cord-002530-ao7kenbx	48	3	fibroblast	fibroblast	NN
cord-002530-ao7kenbx	48	4	cells	cell	NNS
cord-002530-ao7kenbx	48	5	were	be	VBD
cord-002530-ao7kenbx	48	6	double	double	RB
cord-002530-ao7kenbx	48	7	transfected	transfecte	VBN
cord-002530-ao7kenbx	48	8	with	with	IN
cord-002530-ao7kenbx	48	9	each	each	DT
cord-002530-ao7kenbx	48	10	siRNA	siRNA	NNP
cord-002530-ao7kenbx	48	11	pool	pool	NN
cord-002530-ao7kenbx	48	12	in	in	IN
cord-002530-ao7kenbx	48	13	96	96	CD
cord-002530-ao7kenbx	48	14	well	well	JJ
cord-002530-ao7kenbx	48	15	format	format	NN
cord-002530-ao7kenbx	48	16	.	.	.
cord-002530-ao7kenbx	49	1	Two	two	CD
cord-002530-ao7kenbx	49	2	days	day	NNS
cord-002530-ao7kenbx	49	3	post	post	NN
cord-002530-ao7kenbx	49	4	-	-	NN
cord-002530-ao7kenbx	49	5	transfection	transfection	JJ
cord-002530-ao7kenbx	49	6	,	,	,
cord-002530-ao7kenbx	49	7	the	the	DT
cord-002530-ao7kenbx	49	8	cells	cell	NNS
cord-002530-ao7kenbx	49	9	were	be	VBD
cord-002530-ao7kenbx	49	10	infected	infect	VBN
cord-002530-ao7kenbx	49	11	with	with	IN
cord-002530-ao7kenbx	49	12	a	a	DT
cord-002530-ao7kenbx	49	13	low	low	JJ
cord-002530-ao7kenbx	49	14	passage	passage	NN
cord-002530-ao7kenbx	49	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	49	16	strain	strain	NN
cord-002530-ao7kenbx	49	17	,	,	,
cord-002530-ao7kenbx	49	18	TB40E	tb40e	NN
cord-002530-ao7kenbx	49	19	,	,	,
cord-002530-ao7kenbx	49	20	expressing	express	VBG
cord-002530-ao7kenbx	49	21	GFP	GFP	NNP
cord-002530-ao7kenbx	49	22	from	from	IN
cord-002530-ao7kenbx	49	23	an	an	DT
cord-002530-ao7kenbx	49	24	SV40	SV40	NNP
cord-002530-ao7kenbx	49	25	promoter	promoter	NN
cord-002530-ao7kenbx	49	26	.	.	.
cord-002530-ao7kenbx	50	1	GFP	GFP	NNP
cord-002530-ao7kenbx	50	2	levels	level	NNS
cord-002530-ao7kenbx	50	3	were	be	VBD
cord-002530-ao7kenbx	50	4	monitored	monitor	VBN
cord-002530-ao7kenbx	50	5	over	over	IN
cord-002530-ao7kenbx	50	6	a	a	DT
cord-002530-ao7kenbx	50	7	period	period	NN
cord-002530-ao7kenbx	50	8	of	of	IN
cord-002530-ao7kenbx	50	9	seven	seven	CD
cord-002530-ao7kenbx	50	10	days	day	NNS
cord-002530-ao7kenbx	50	11	by	by	IN
cord-002530-ao7kenbx	50	12	fluorometry	fluorometry	NN
cord-002530-ao7kenbx	50	13	to	to	TO
cord-002530-ao7kenbx	50	14	determine	determine	VB
cord-002530-ao7kenbx	50	15	virus	virus	NN
cord-002530-ao7kenbx	50	16	infection	infection	NN
cord-002530-ao7kenbx	50	17	and	and	CC
cord-002530-ao7kenbx	50	18	replication	replication	NN
cord-002530-ao7kenbx	50	19	levels	level	NNS
cord-002530-ao7kenbx	50	20	(	(	-LRB-
cord-002530-ao7kenbx	50	21	S1	S1	NNP
cord-002530-ao7kenbx	50	22	Table	Table	NNP
cord-002530-ao7kenbx	50	23	)	)	-RRB-
cord-002530-ao7kenbx	50	24	.	.	.
cord-002530-ao7kenbx	51	1	Analysis	analysis	NN
cord-002530-ao7kenbx	51	2	of	of	IN
cord-002530-ao7kenbx	51	3	the	the	DT
cord-002530-ao7kenbx	51	4	screen	screen	NN
cord-002530-ao7kenbx	51	5	indicated	indicate	VBD
cord-002530-ao7kenbx	51	6	both	both	CC
cord-002530-ao7kenbx	51	7	increased	increase	VBD
cord-002530-ao7kenbx	51	8	and	and	CC
cord-002530-ao7kenbx	51	9	decreased	decrease	VBD
cord-002530-ao7kenbx	51	10	virus	virus	NN
cord-002530-ao7kenbx	51	11	replication	replication	NN
cord-002530-ao7kenbx	51	12	ranging	range	VBG
cord-002530-ao7kenbx	51	13	from	from	IN
cord-002530-ao7kenbx	51	14	88	88	CD
cord-002530-ao7kenbx	51	15	%	%	NN
cord-002530-ao7kenbx	51	16	reduction	reduction	NN
cord-002530-ao7kenbx	51	17	in	in	IN
cord-002530-ao7kenbx	51	18	GFP	GFP	NNP
cord-002530-ao7kenbx	51	19	levels	level	NNS
cord-002530-ao7kenbx	51	20	to	to	IN
cord-002530-ao7kenbx	51	21	a	a	DT
cord-002530-ao7kenbx	51	22	84	84	CD
cord-002530-ao7kenbx	51	23	%	%	NN
cord-002530-ao7kenbx	51	24	increase	increase	NN
cord-002530-ao7kenbx	51	25	(	(	-LRB-
cord-002530-ao7kenbx	51	26	Fig	Fig	NNP
cord-002530-ao7kenbx	51	27	2A	2a	CD
cord-002530-ao7kenbx	51	28	)	)	-RRB-
cord-002530-ao7kenbx	51	29	.	.	.
cord-002530-ao7kenbx	52	1	Z	z	NN
cord-002530-ao7kenbx	52	2	-	-	HYPH
cord-002530-ao7kenbx	52	3	score	score	NN
cord-002530-ao7kenbx	52	4	analysis	analysis	NN
cord-002530-ao7kenbx	52	5	based	base	VBN
cord-002530-ao7kenbx	52	6	on	on	IN
cord-002530-ao7kenbx	52	7	three	three	CD
cord-002530-ao7kenbx	52	8	biological	biological	JJ
cord-002530-ao7kenbx	52	9	repeats	repeat	NNS
cord-002530-ao7kenbx	52	10	of	of	IN
cord-002530-ao7kenbx	52	11	the	the	DT
cord-002530-ao7kenbx	52	12	siRNA	siRNA	NNP
cord-002530-ao7kenbx	52	13	screen	screen	NN
cord-002530-ao7kenbx	52	14	identified	identify	VBD
cord-002530-ao7kenbx	52	15	five	five	CD
cord-002530-ao7kenbx	52	16	clear	clear	JJ
cord-002530-ao7kenbx	52	17	outliers	outlier	NNS
cord-002530-ao7kenbx	52	18	that	that	WDT
cord-002530-ao7kenbx	52	19	resulted	result	VBD
cord-002530-ao7kenbx	52	20	in	in	IN
cord-002530-ao7kenbx	52	21	reproducible	reproducible	JJ
cord-002530-ao7kenbx	52	22	reductions	reduction	NNS
cord-002530-ao7kenbx	52	23	in	in	IN
cord-002530-ao7kenbx	52	24	virus	virus	NN
cord-002530-ao7kenbx	52	25	replication	replication	NN
cord-002530-ao7kenbx	52	26	,	,	,
cord-002530-ao7kenbx	52	27	as	as	IN
cord-002530-ao7kenbx	52	28	measured	measure	VBN
cord-002530-ao7kenbx	52	29	by	by	IN
cord-002530-ao7kenbx	52	30	GFP	GFP	NNP
cord-002530-ao7kenbx	52	31	fluorescence	fluorescence	NN
cord-002530-ao7kenbx	52	32	intensity	intensity	NN
cord-002530-ao7kenbx	52	33	(	(	-LRB-
cord-002530-ao7kenbx	52	34	Fig	Fig	NNP
cord-002530-ao7kenbx	52	35	2B	2b	CD
cord-002530-ao7kenbx	52	36	)	)	-RRB-
cord-002530-ao7kenbx	52	37	.	.	.
cord-002530-ao7kenbx	53	1	Of	of	IN
cord-002530-ao7kenbx	53	2	these	these	DT
cord-002530-ao7kenbx	53	3	,	,	,
cord-002530-ao7kenbx	53	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	53	5	of	of	IN
cord-002530-ao7kenbx	53	6	VCP	VCP	NNP
cord-002530-ao7kenbx	53	7	resulted	result	VBD
cord-002530-ao7kenbx	53	8	in	in	IN
cord-002530-ao7kenbx	53	9	the	the	DT
cord-002530-ao7kenbx	53	10	largest	large	JJS
cord-002530-ao7kenbx	53	11	negative	negative	JJ
cord-002530-ao7kenbx	53	12	Z	z	NN
cord-002530-ao7kenbx	53	13	-	-	HYPH
cord-002530-ao7kenbx	53	14	score	score	NN
cord-002530-ao7kenbx	53	15	.	.	.
cord-002530-ao7kenbx	54	1	To	to	TO
cord-002530-ao7kenbx	54	2	validate	validate	VB
cord-002530-ao7kenbx	54	3	that	that	IN
cord-002530-ao7kenbx	54	4	the	the	DT
cord-002530-ao7kenbx	54	5	observed	observed	JJ
cord-002530-ao7kenbx	54	6	phenotype	phenotype	NN
cord-002530-ao7kenbx	54	7	was	be	VBD
cord-002530-ao7kenbx	54	8	due	due	JJ
cord-002530-ao7kenbx	54	9	to	to	IN
cord-002530-ao7kenbx	54	10	knockdown	knockdown	NN
cord-002530-ao7kenbx	54	11	of	of	IN
cord-002530-ao7kenbx	54	12	VCP	VCP	NNP
cord-002530-ao7kenbx	54	13	,	,	,
cord-002530-ao7kenbx	54	14	rather	rather	RB
cord-002530-ao7kenbx	54	15	than	than	IN
cord-002530-ao7kenbx	54	16	potential	potential	JJ
cord-002530-ao7kenbx	54	17	off	off	IN
cord-002530-ao7kenbx	54	18	-	-	HYPH
cord-002530-ao7kenbx	54	19	target	target	NN
cord-002530-ao7kenbx	54	20	effects	effect	NNS
cord-002530-ao7kenbx	54	21	,	,	,
cord-002530-ao7kenbx	54	22	the	the	DT
cord-002530-ao7kenbx	54	23	original	original	JJ
cord-002530-ao7kenbx	54	24	siRNA	siRNA	NNP
cord-002530-ao7kenbx	54	25	pool	pool	NN
cord-002530-ao7kenbx	54	26	was	be	VBD
cord-002530-ao7kenbx	54	27	deconvoluted	deconvolute	VBN
cord-002530-ao7kenbx	54	28	to	to	TO
cord-002530-ao7kenbx	54	29	test	test	VB
cord-002530-ao7kenbx	54	30	the	the	DT
cord-002530-ao7kenbx	54	31	four	four	CD
cord-002530-ao7kenbx	54	32	individual	individual	JJ
cord-002530-ao7kenbx	54	33	siRNAs	siRNAs	NNP
cord-002530-ao7kenbx	54	34	against	against	IN
cord-002530-ao7kenbx	54	35	VCP	VCP	NNP
cord-002530-ao7kenbx	54	36	.	.	.
cord-002530-ao7kenbx	55	1	All	all	DT
cord-002530-ao7kenbx	55	2	four	four	CD
cord-002530-ao7kenbx	55	3	siRNAs	sirna	NNS
cord-002530-ao7kenbx	55	4	resulted	result	VBD
cord-002530-ao7kenbx	55	5	in	in	IN
cord-002530-ao7kenbx	55	6	reduced	reduce	VBN
cord-002530-ao7kenbx	55	7	VCP	vcp	NN
cord-002530-ao7kenbx	55	8	expression	expression	NN
cord-002530-ao7kenbx	55	9	and	and	CC
cord-002530-ao7kenbx	55	10	reduced	reduce	VBN
cord-002530-ao7kenbx	55	11	HCMV	HCMV	NNP
cord-002530-ao7kenbx	55	12	replication	replication	NN
cord-002530-ao7kenbx	55	13	based	base	VBN
cord-002530-ao7kenbx	55	14	on	on	IN
cord-002530-ao7kenbx	55	15	GFP	GFP	NNP
cord-002530-ao7kenbx	55	16	fluorescence	fluorescence	NN
cord-002530-ao7kenbx	55	17	(	(	-LRB-
cord-002530-ao7kenbx	55	18	Fig	Fig	NNP
cord-002530-ao7kenbx	55	19	2C	2c	NN
cord-002530-ao7kenbx	55	20	)	)	-RRB-
cord-002530-ao7kenbx	55	21	.	.	.
cord-002530-ao7kenbx	56	1	The	the	DT
cord-002530-ao7kenbx	56	2	third	third	JJ
cord-002530-ao7kenbx	56	3	siRNA	siRNA	NNP
cord-002530-ao7kenbx	56	4	of	of	IN
cord-002530-ao7kenbx	56	5	the	the	DT
cord-002530-ao7kenbx	56	6	pool	pool	NN
cord-002530-ao7kenbx	56	7	generated	generate	VBD
cord-002530-ao7kenbx	56	8	less	less	RBR
cord-002530-ao7kenbx	56	9	efficient	efficient	JJ
cord-002530-ao7kenbx	56	10	VCP	vcp	NN
cord-002530-ao7kenbx	56	11	knockdown	knockdown	NN
cord-002530-ao7kenbx	56	12	,	,	,
cord-002530-ao7kenbx	56	13	and	and	CC
cord-002530-ao7kenbx	56	14	corresponded	correspond	VBD
cord-002530-ao7kenbx	56	15	with	with	IN
cord-002530-ao7kenbx	56	16	less	less	JJR
cord-002530-ao7kenbx	56	17	inhibition	inhibition	NN
cord-002530-ao7kenbx	56	18	of	of	IN
cord-002530-ao7kenbx	56	19	HCMV	HCMV	NNP
cord-002530-ao7kenbx	56	20	in	in	IN
cord-002530-ao7kenbx	56	21	the	the	DT
cord-002530-ao7kenbx	56	22	siRNA	siRNA	NNP
cord-002530-ao7kenbx	56	23	assay	assay	NN
cord-002530-ao7kenbx	56	24	,	,	,
cord-002530-ao7kenbx	56	25	providing	provide	VBG
cord-002530-ao7kenbx	56	26	additional	additional	JJ
cord-002530-ao7kenbx	56	27	evidence	evidence	NN
cord-002530-ao7kenbx	56	28	that	that	IN
cord-002530-ao7kenbx	56	29	knockdown	knockdown	NN
cord-002530-ao7kenbx	56	30	of	of	IN
cord-002530-ao7kenbx	56	31	VCP	VCP	NNP
cord-002530-ao7kenbx	56	32	results	result	NNS
cord-002530-ao7kenbx	56	33	in	in	IN
cord-002530-ao7kenbx	56	34	a	a	DT
cord-002530-ao7kenbx	56	35	direct	direct	JJ
cord-002530-ao7kenbx	56	36	reduction	reduction	NN
cord-002530-ao7kenbx	56	37	in	in	IN
cord-002530-ao7kenbx	56	38	virus	virus	NN
cord-002530-ao7kenbx	56	39	replication	replication	NN
cord-002530-ao7kenbx	56	40	.	.	.
cord-002530-ao7kenbx	57	1	These	these	DT
cord-002530-ao7kenbx	57	2	results	result	NNS
cord-002530-ao7kenbx	57	3	indicate	indicate	VBP
cord-002530-ao7kenbx	57	4	that	that	IN
cord-002530-ao7kenbx	57	5	the	the	DT
cord-002530-ao7kenbx	57	6	initial	initial	JJ
cord-002530-ao7kenbx	57	7	observed	observed	JJ
cord-002530-ao7kenbx	57	8	phenotype	phenotype	NN
cord-002530-ao7kenbx	57	9	is	be	VBZ
cord-002530-ao7kenbx	57	10	due	due	JJ
cord-002530-ao7kenbx	57	11	to	to	IN
cord-002530-ao7kenbx	57	12	specific	specific	JJ
cord-002530-ao7kenbx	57	13	knockdown	knockdown	NN
cord-002530-ao7kenbx	57	14	of	of	IN
cord-002530-ao7kenbx	57	15	VCP	VCP	NNP
cord-002530-ao7kenbx	57	16	rather	rather	RB
cord-002530-ao7kenbx	57	17	than	than	IN
cord-002530-ao7kenbx	57	18	off	off	IN
cord-002530-ao7kenbx	57	19	-	-	HYPH
cord-002530-ao7kenbx	57	20	target	target	NN
cord-002530-ao7kenbx	57	21	artefactual	artefactual	JJ
cord-002530-ao7kenbx	57	22	effects	effect	NNS
cord-002530-ao7kenbx	57	23	of	of	IN
cord-002530-ao7kenbx	57	24	the	the	DT
cord-002530-ao7kenbx	57	25	siRNAs	siRNAs	NNP
cord-002530-ao7kenbx	57	26	.	.	.
cord-002530-ao7kenbx	58	1	Although	although	IN
cord-002530-ao7kenbx	58	2	GFP	GFP	NNP
cord-002530-ao7kenbx	58	3	expression	expression	NN
cord-002530-ao7kenbx	58	4	serves	serve	VBZ
cord-002530-ao7kenbx	58	5	as	as	IN
cord-002530-ao7kenbx	58	6	an	an	DT
cord-002530-ao7kenbx	58	7	effective	effective	JJ
cord-002530-ao7kenbx	58	8	read	read	NN
cord-002530-ao7kenbx	58	9	-	-	HYPH
cord-002530-ao7kenbx	58	10	out	out	NN
cord-002530-ao7kenbx	58	11	for	for	IN
cord-002530-ao7kenbx	58	12	virus	virus	NN
cord-002530-ao7kenbx	58	13	replication	replication	NN
cord-002530-ao7kenbx	58	14	,	,	,
cord-002530-ao7kenbx	58	15	loss	loss	NN
cord-002530-ao7kenbx	58	16	of	of	IN
cord-002530-ao7kenbx	58	17	GFP	GFP	NNP
cord-002530-ao7kenbx	58	18	signal	signal	NN
cord-002530-ao7kenbx	58	19	may	may	MD
cord-002530-ao7kenbx	58	20	not	not	RB
cord-002530-ao7kenbx	58	21	necessarily	necessarily	RB
cord-002530-ao7kenbx	58	22	reflect	reflect	VB
cord-002530-ao7kenbx	58	23	reduced	reduce	VBN
cord-002530-ao7kenbx	58	24	virus	virus	NN
cord-002530-ao7kenbx	58	25	production	production	NN
cord-002530-ao7kenbx	58	26	.	.	.
cord-002530-ao7kenbx	59	1	To	to	TO
cord-002530-ao7kenbx	59	2	determine	determine	VB
cord-002530-ao7kenbx	59	3	the	the	DT
cord-002530-ao7kenbx	59	4	direct	direct	JJ
cord-002530-ao7kenbx	59	5	effect	effect	NN
cord-002530-ao7kenbx	59	6	of	of	IN
cord-002530-ao7kenbx	59	7	VCP	VCP	NNP
cord-002530-ao7kenbx	59	8	knockdown	knockdown	NN
cord-002530-ao7kenbx	59	9	on	on	IN
cord-002530-ao7kenbx	59	10	HCMV	HCMV	NNP
cord-002530-ao7kenbx	59	11	virus	virus	NN
cord-002530-ao7kenbx	59	12	production	production	NN
cord-002530-ao7kenbx	59	13	,	,	,
cord-002530-ao7kenbx	59	14	one	one	CD
cord-002530-ao7kenbx	59	15	-	-	HYPH
cord-002530-ao7kenbx	59	16	step	step	NN
cord-002530-ao7kenbx	59	17	growth	growth	NN
cord-002530-ao7kenbx	59	18	curves	curve	NNS
cord-002530-ao7kenbx	59	19	were	be	VBD
cord-002530-ao7kenbx	59	20	generated	generate	VBN
cord-002530-ao7kenbx	59	21	.	.	.
cord-002530-ao7kenbx	60	1	Primary	primary	JJ
cord-002530-ao7kenbx	60	2	human	human	JJ
cord-002530-ao7kenbx	60	3	fibroblast	fibroblast	NN
cord-002530-ao7kenbx	60	4	cells	cell	NNS
cord-002530-ao7kenbx	60	5	were	be	VBD
cord-002530-ao7kenbx	60	6	transfected	transfecte	VBN
cord-002530-ao7kenbx	60	7	with	with	IN
cord-002530-ao7kenbx	60	8	siRNA	siRNA	NNP
cord-002530-ao7kenbx	60	9	pools	pool	NNS
cord-002530-ao7kenbx	60	10	targeting	target	VBG
cord-002530-ao7kenbx	60	11	VCP	VCP	NNP
cord-002530-ao7kenbx	60	12	or	or	CC
cord-002530-ao7kenbx	60	13	a	a	DT
cord-002530-ao7kenbx	60	14	negative	negative	JJ
cord-002530-ao7kenbx	60	15	control	control	NN
cord-002530-ao7kenbx	60	16	non	non	JJ
cord-002530-ao7kenbx	60	17	-	-	JJ
cord-002530-ao7kenbx	60	18	targeting	targeting	JJ
cord-002530-ao7kenbx	60	19	siRNA	siRNA	NNP
cord-002530-ao7kenbx	60	20	.	.	.
cord-002530-ao7kenbx	61	1	Two	two	CD
cord-002530-ao7kenbx	61	2	days	day	NNS
cord-002530-ao7kenbx	61	3	post	post	VBP
cord-002530-ao7kenbx	61	4	transfection	transfection	NN
cord-002530-ao7kenbx	61	5	cells	cell	NNS
cord-002530-ao7kenbx	61	6	were	be	VBD
cord-002530-ao7kenbx	61	7	infected	infect	VBN
cord-002530-ao7kenbx	61	8	at	at	IN
cord-002530-ao7kenbx	61	9	a	a	DT
cord-002530-ao7kenbx	61	10	multiplicity	multiplicity	NN
cord-002530-ao7kenbx	61	11	of	of	IN
cord-002530-ao7kenbx	61	12	infection	infection	NN
cord-002530-ao7kenbx	61	13	(	(	-LRB-
cord-002530-ao7kenbx	61	14	MOI	MOI	NNP
cord-002530-ao7kenbx	61	15	)	)	-RRB-
cord-002530-ao7kenbx	61	16	of	of	IN
cord-002530-ao7kenbx	61	17	three	three	CD
cord-002530-ao7kenbx	61	18	with	with	IN
cord-002530-ao7kenbx	61	19	TB40E	tb40e	NN
cord-002530-ao7kenbx	61	20	-	-	HYPH
cord-002530-ao7kenbx	61	21	GFP	GFP	NNP
cord-002530-ao7kenbx	61	22	.	.	.
cord-002530-ao7kenbx	62	1	Supernatant	Supernatant	NNP
cord-002530-ao7kenbx	62	2	was	be	VBD
cord-002530-ao7kenbx	62	3	collected	collect	VBN
cord-002530-ao7kenbx	62	4	at	at	IN
cord-002530-ao7kenbx	62	5	24hour	24hour	JJ
cord-002530-ao7kenbx	62	6	time	time	NN
cord-002530-ao7kenbx	62	7	points	point	NNS
cord-002530-ao7kenbx	62	8	for	for	IN
cord-002530-ao7kenbx	62	9	seven	seven	CD
cord-002530-ao7kenbx	62	10	days	day	NNS
cord-002530-ao7kenbx	62	11	total	total	JJ
cord-002530-ao7kenbx	62	12	.	.	.
cord-002530-ao7kenbx	63	1	Knockdown	knockdown	NN
cord-002530-ao7kenbx	63	2	of	of	IN
cord-002530-ao7kenbx	63	3	VCP	VCP	NNP
cord-002530-ao7kenbx	63	4	resulted	result	VBD
cord-002530-ao7kenbx	63	5	in	in	IN
cord-002530-ao7kenbx	63	6	significant	significant	JJ
cord-002530-ao7kenbx	63	7	reduction	reduction	NN
cord-002530-ao7kenbx	63	8	in	in	IN
cord-002530-ao7kenbx	63	9	HCMV	HCMV	NNP
cord-002530-ao7kenbx	63	10	replication	replication	NN
cord-002530-ao7kenbx	63	11	,	,	,
cord-002530-ao7kenbx	63	12	with	with	IN
cord-002530-ao7kenbx	63	13	viral	viral	JJ
cord-002530-ao7kenbx	63	14	titers	titer	NNS
cord-002530-ao7kenbx	63	15	over	over	IN
cord-002530-ao7kenbx	63	16	four	four	CD
cord-002530-ao7kenbx	63	17	log	log	NN
cord-002530-ao7kenbx	63	18	10	10	CD
cord-002530-ao7kenbx	63	19	lower	low	JJR
cord-002530-ao7kenbx	63	20	in	in	IN
cord-002530-ao7kenbx	63	21	cells	cell	NNS
cord-002530-ao7kenbx	63	22	depleted	deplete	VBN
cord-002530-ao7kenbx	63	23	of	of	IN
cord-002530-ao7kenbx	63	24	VCP	vcp	NN
cord-002530-ao7kenbx	63	25	compared	compare	VBN
cord-002530-ao7kenbx	63	26	to	to	IN
cord-002530-ao7kenbx	63	27	negative	negative	JJ
cord-002530-ao7kenbx	63	28	control	control	NN
cord-002530-ao7kenbx	63	29	cells	cell	NNS
cord-002530-ao7kenbx	63	30	at	at	IN
cord-002530-ao7kenbx	63	31	day	day	NN
cord-002530-ao7kenbx	63	32	seven	seven	CD
cord-002530-ao7kenbx	63	33	(	(	-LRB-
cord-002530-ao7kenbx	63	34	Fig	Fig	NNP
cord-002530-ao7kenbx	63	35	2D	2d	NN
cord-002530-ao7kenbx	63	36	)	)	-RRB-
cord-002530-ao7kenbx	63	37	.	.	.
cord-002530-ao7kenbx	64	1	No	no	DT
cord-002530-ao7kenbx	64	2	amplification	amplification	NN
cord-002530-ao7kenbx	64	3	of	of	IN
cord-002530-ao7kenbx	64	4	infectious	infectious	JJ
cord-002530-ao7kenbx	64	5	virus	virus	NN
cord-002530-ao7kenbx	64	6	was	be	VBD
cord-002530-ao7kenbx	64	7	observed	observe	VBN
cord-002530-ao7kenbx	64	8	in	in	IN
cord-002530-ao7kenbx	64	9	cells	cell	NNS
cord-002530-ao7kenbx	64	10	knocked	knock	VBD
cord-002530-ao7kenbx	64	11	down	down	RP
cord-002530-ao7kenbx	64	12	for	for	IN
cord-002530-ao7kenbx	64	13	VCP	VCP	NNP
cord-002530-ao7kenbx	64	14	,	,	,
cord-002530-ao7kenbx	64	15	suggesting	suggest	VBG
cord-002530-ao7kenbx	64	16	a	a	DT
cord-002530-ao7kenbx	64	17	complete	complete	JJ
cord-002530-ao7kenbx	64	18	block	block	NN
cord-002530-ao7kenbx	64	19	in	in	IN
cord-002530-ao7kenbx	64	20	virus	virus	NN
cord-002530-ao7kenbx	64	21	replication	replication	NN
cord-002530-ao7kenbx	64	22	.	.	.
cord-002530-ao7kenbx	65	1	Cell	cell	NN
cord-002530-ao7kenbx	65	2	viability	viability	NN
cord-002530-ao7kenbx	65	3	assays	assay	NNS
cord-002530-ao7kenbx	65	4	showed	show	VBD
cord-002530-ao7kenbx	65	5	a	a	DT
cord-002530-ao7kenbx	65	6	moderate	moderate	JJ
cord-002530-ao7kenbx	65	7	decrease	decrease	NN
cord-002530-ao7kenbx	65	8	in	in	IN
cord-002530-ao7kenbx	65	9	cell	cell	NN
cord-002530-ao7kenbx	65	10	viability	viability	NN
cord-002530-ao7kenbx	65	11	at	at	IN
cord-002530-ao7kenbx	65	12	5	5	CD
cord-002530-ao7kenbx	65	13	days	day	NNS
cord-002530-ao7kenbx	65	14	post	post	NN
cord-002530-ao7kenbx	65	15	transfection	transfection	NN
cord-002530-ao7kenbx	65	16	with	with	IN
cord-002530-ao7kenbx	65	17	VCP	VCP	NNP
cord-002530-ao7kenbx	65	18	siRNA	siRNA	NNP
cord-002530-ao7kenbx	65	19	compared	compare	VBN
cord-002530-ao7kenbx	65	20	to	to	IN
cord-002530-ao7kenbx	65	21	negative	negative	JJ
cord-002530-ao7kenbx	65	22	control	control	NN
cord-002530-ao7kenbx	65	23	siRNA	siRNA	NNP
cord-002530-ao7kenbx	65	24	,	,	,
cord-002530-ao7kenbx	65	25	although	although	IN
cord-002530-ao7kenbx	65	26	visual	visual	JJ
cord-002530-ao7kenbx	65	27	inspection	inspection	NN
cord-002530-ao7kenbx	65	28	of	of	IN
cord-002530-ao7kenbx	65	29	cells	cell	NNS
cord-002530-ao7kenbx	65	30	did	do	VBD
cord-002530-ao7kenbx	65	31	not	not	RB
cord-002530-ao7kenbx	65	32	indicate	indicate	VB
cord-002530-ao7kenbx	65	33	gross	gross	JJ
cord-002530-ao7kenbx	65	34	cytotoxicity	cytotoxicity	NN
cord-002530-ao7kenbx	65	35	and	and	CC
cord-002530-ao7kenbx	65	36	the	the	DT
cord-002530-ao7kenbx	65	37	reduction	reduction	NN
cord-002530-ao7kenbx	65	38	is	be	VBZ
cord-002530-ao7kenbx	65	39	not	not	RB
cord-002530-ao7kenbx	65	40	sufficient	sufficient	JJ
cord-002530-ao7kenbx	65	41	to	to	TO
cord-002530-ao7kenbx	65	42	account	account	VB
cord-002530-ao7kenbx	65	43	for	for	IN
cord-002530-ao7kenbx	65	44	the	the	DT
cord-002530-ao7kenbx	65	45	substantial	substantial	JJ
cord-002530-ao7kenbx	65	46	reduction	reduction	NN
cord-002530-ao7kenbx	65	47	in	in	IN
cord-002530-ao7kenbx	65	48	virus	virus	NN
cord-002530-ao7kenbx	65	49	replication	replication	NN
cord-002530-ao7kenbx	65	50	(	(	-LRB-
cord-002530-ao7kenbx	65	51	S1	S1	NNP
cord-002530-ao7kenbx	65	52	Fig	Fig	NNP
cord-002530-ao7kenbx	65	53	)	)	-RRB-
cord-002530-ao7kenbx	65	54	.	.	.
cord-002530-ao7kenbx	66	1	VCP	VCP	NNP
cord-002530-ao7kenbx	66	2	is	be	VBZ
cord-002530-ao7kenbx	66	3	required	require	VBN
cord-002530-ao7kenbx	66	4	for	for	IN
cord-002530-ao7kenbx	66	5	IE2	ie2	JJ
cord-002530-ao7kenbx	66	6	expression	expression	NN
cord-002530-ao7kenbx	66	7	but	but	CC
cord-002530-ao7kenbx	66	8	not	not	RB
cord-002530-ao7kenbx	66	9	IE1	ie1	NN
cord-002530-ao7kenbx	66	10	expression	expression	NN
cord-002530-ao7kenbx	67	1	Further	further	JJ
cord-002530-ao7kenbx	67	2	characterization	characterization	NN
cord-002530-ao7kenbx	67	3	was	be	VBD
cord-002530-ao7kenbx	67	4	performed	perform	VBN
cord-002530-ao7kenbx	67	5	to	to	TO
cord-002530-ao7kenbx	67	6	determine	determine	VB
cord-002530-ao7kenbx	67	7	at	at	IN
cord-002530-ao7kenbx	67	8	what	what	WDT
cord-002530-ao7kenbx	67	9	stage	stage	NN
cord-002530-ao7kenbx	67	10	of	of	IN
cord-002530-ao7kenbx	67	11	the	the	DT
cord-002530-ao7kenbx	67	12	HCMV	HCMV	NNP
cord-002530-ao7kenbx	67	13	replication	replication	NN
cord-002530-ao7kenbx	67	14	cycle	cycle	NN
cord-002530-ao7kenbx	67	15	VCP	VCP	NNP
cord-002530-ao7kenbx	67	16	is	be	VBZ
cord-002530-ao7kenbx	67	17	required	require	VBN
cord-002530-ao7kenbx	67	18	.	.	.
cord-002530-ao7kenbx	68	1	Analysis	analysis	NN
cord-002530-ao7kenbx	68	2	of	of	IN
cord-002530-ao7kenbx	68	3	GFP	GFP	NNP
cord-002530-ao7kenbx	68	4	fluorescence	fluorescence	NN
cord-002530-ao7kenbx	68	5	at	at	IN
cord-002530-ao7kenbx	68	6	48	48	CD
cord-002530-ao7kenbx	68	7	hours	hour	NNS
cord-002530-ao7kenbx	68	8	post	post	NN
cord-002530-ao7kenbx	68	9	infection	infection	NN
cord-002530-ao7kenbx	68	10	(	(	-LRB-
cord-002530-ao7kenbx	68	11	HPI	HPI	NNP
cord-002530-ao7kenbx	68	12	)	)	-RRB-
cord-002530-ao7kenbx	68	13	indicated	indicate	VBD
cord-002530-ao7kenbx	68	14	that	that	IN
cord-002530-ao7kenbx	68	15	all	all	DT
cord-002530-ao7kenbx	68	16	cells	cell	NNS
cord-002530-ao7kenbx	68	17	were	be	VBD
cord-002530-ao7kenbx	68	18	infected	infect	VBN
cord-002530-ao7kenbx	68	19	,	,	,
cord-002530-ao7kenbx	68	20	demonstrating	demonstrate	VBG
cord-002530-ao7kenbx	68	21	that	that	IN
cord-002530-ao7kenbx	68	22	VCP	VCP	NNP
cord-002530-ao7kenbx	68	23	expression	expression	NN
cord-002530-ao7kenbx	68	24	is	be	VBZ
cord-002530-ao7kenbx	68	25	not	not	RB
cord-002530-ao7kenbx	68	26	required	require	VBN
cord-002530-ao7kenbx	68	27	for	for	IN
cord-002530-ao7kenbx	68	28	virus	virus	NN
cord-002530-ao7kenbx	68	29	entry	entry	NN
cord-002530-ao7kenbx	68	30	,	,	,
cord-002530-ao7kenbx	68	31	translocation	translocation	NN
cord-002530-ao7kenbx	68	32	of	of	IN
cord-002530-ao7kenbx	68	33	genome	genome	NN
cord-002530-ao7kenbx	68	34	to	to	IN
cord-002530-ao7kenbx	68	35	the	the	DT
cord-002530-ao7kenbx	68	36	nucleus	nucleus	NN
cord-002530-ao7kenbx	68	37	or	or	CC
cord-002530-ao7kenbx	68	38	initial	initial	JJ
cord-002530-ao7kenbx	68	39	transcription	transcription	NN
cord-002530-ao7kenbx	68	40	of	of	IN
cord-002530-ao7kenbx	68	41	the	the	DT
cord-002530-ao7kenbx	68	42	viral	viral	JJ
cord-002530-ao7kenbx	68	43	genome	genome	NN
cord-002530-ao7kenbx	68	44	(	(	-LRB-
cord-002530-ao7kenbx	68	45	Fig	Fig	NNP
cord-002530-ao7kenbx	68	46	3A	3a	CD
cord-002530-ao7kenbx	68	47	)	)	-RRB-
cord-002530-ao7kenbx	68	48	.	.	.
cord-002530-ao7kenbx	69	1	Western	western	JJ
cord-002530-ao7kenbx	69	2	blot	blot	NN
cord-002530-ao7kenbx	69	3	analysis	analysis	NN
cord-002530-ao7kenbx	69	4	was	be	VBD
cord-002530-ao7kenbx	69	5	performed	perform	VBN
cord-002530-ao7kenbx	69	6	to	to	TO
cord-002530-ao7kenbx	69	7	measure	measure	VB
cord-002530-ao7kenbx	69	8	the	the	DT
cord-002530-ao7kenbx	69	9	levels	level	NNS
cord-002530-ao7kenbx	69	10	of	of	IN
cord-002530-ao7kenbx	69	11	each	each	DT
cord-002530-ao7kenbx	69	12	of	of	IN
cord-002530-ao7kenbx	69	13	the	the	DT
cord-002530-ao7kenbx	69	14	major	major	JJ
cord-002530-ao7kenbx	69	15	kinetic	kinetic	JJ
cord-002530-ao7kenbx	69	16	classes	class	NNS
cord-002530-ao7kenbx	69	17	of	of	IN
cord-002530-ao7kenbx	69	18	HCMV	HCMV	NNP
cord-002530-ao7kenbx	69	19	genes	gene	NNS
cord-002530-ao7kenbx	69	20	,	,	,
cord-002530-ao7kenbx	69	21	including	include	VBG
cord-002530-ao7kenbx	69	22	immediate	immediate	JJ
cord-002530-ao7kenbx	69	23	early	early	JJ
cord-002530-ao7kenbx	69	24	(	(	-LRB-
cord-002530-ao7kenbx	69	25	IE1	ie1	NN
cord-002530-ao7kenbx	69	26	and	and	CC
cord-002530-ao7kenbx	69	27	IE2	IE2	NNP
cord-002530-ao7kenbx	69	28	)	)	-RRB-
cord-002530-ao7kenbx	69	29	,	,	,
cord-002530-ao7kenbx	69	30	early	early	JJ
cord-002530-ao7kenbx	69	31	(	(	-LRB-
cord-002530-ao7kenbx	69	32	pp52	pp52	NN
cord-002530-ao7kenbx	69	33	)	)	-RRB-
cord-002530-ao7kenbx	69	34	and	and	CC
cord-002530-ao7kenbx	69	35	late	late	JJ
cord-002530-ao7kenbx	69	36	(	(	-LRB-
cord-002530-ao7kenbx	69	37	pp28	pp28	NNP
cord-002530-ao7kenbx	69	38	)	)	-RRB-
cord-002530-ao7kenbx	69	39	,	,	,
cord-002530-ao7kenbx	69	40	to	to	TO
cord-002530-ao7kenbx	69	41	define	define	VB
cord-002530-ao7kenbx	69	42	when	when	WRB
cord-002530-ao7kenbx	69	43	disruption	disruption	NN
cord-002530-ao7kenbx	69	44	in	in	IN
cord-002530-ao7kenbx	69	45	virus	virus	NN
cord-002530-ao7kenbx	69	46	replication	replication	NN
cord-002530-ao7kenbx	69	47	occurs	occur	VBZ
cord-002530-ao7kenbx	69	48	(	(	-LRB-
cord-002530-ao7kenbx	69	49	Fig	Fig	NNP
cord-002530-ao7kenbx	69	50	3B	3b	CD
cord-002530-ao7kenbx	69	51	)	)	-RRB-
cord-002530-ao7kenbx	69	52	.	.	.
cord-002530-ao7kenbx	70	1	In	in	IN
cord-002530-ao7kenbx	70	2	control	control	NN
cord-002530-ao7kenbx	70	3	cells	cell	NNS
cord-002530-ao7kenbx	70	4	,	,	,
cord-002530-ao7kenbx	70	5	protein	protein	NN
cord-002530-ao7kenbx	70	6	expression	expression	NN
cord-002530-ao7kenbx	70	7	of	of	IN
cord-002530-ao7kenbx	70	8	each	each	DT
cord-002530-ao7kenbx	70	9	class	class	NN
cord-002530-ao7kenbx	70	10	of	of	IN
cord-002530-ao7kenbx	70	11	virus	virus	NN
cord-002530-ao7kenbx	70	12	gene	gene	NN
cord-002530-ao7kenbx	70	13	is	be	VBZ
cord-002530-ao7kenbx	70	14	clearly	clearly	RB
cord-002530-ao7kenbx	70	15	observed	observe	VBN
cord-002530-ao7kenbx	70	16	.	.	.
cord-002530-ao7kenbx	71	1	However	however	RB
cord-002530-ao7kenbx	71	2	,	,	,
cord-002530-ao7kenbx	71	3	in	in	IN
cord-002530-ao7kenbx	71	4	cells	cell	NNS
cord-002530-ao7kenbx	71	5	knocked	knock	VBD
cord-002530-ao7kenbx	71	6	down	down	RP
cord-002530-ao7kenbx	71	7	for	for	IN
cord-002530-ao7kenbx	71	8	VCP	VCP	NNP
cord-002530-ao7kenbx	71	9	,	,	,
cord-002530-ao7kenbx	71	10	neither	neither	CC
cord-002530-ao7kenbx	71	11	IE2	ie2	NN
cord-002530-ao7kenbx	71	12	nor	nor	CC
cord-002530-ao7kenbx	71	13	downstream	downstream	JJ
cord-002530-ao7kenbx	71	14	viral	viral	JJ
cord-002530-ao7kenbx	71	15	gene	gene	NN
cord-002530-ao7kenbx	71	16	expression	expression	NN
cord-002530-ao7kenbx	71	17	was	be	VBD
cord-002530-ao7kenbx	71	18	detected	detect	VBN
cord-002530-ao7kenbx	71	19	.	.	.
cord-002530-ao7kenbx	72	1	Strikingly	strikingly	RB
cord-002530-ao7kenbx	72	2	,	,	,
cord-002530-ao7kenbx	72	3	despite	despite	IN
cord-002530-ao7kenbx	72	4	being	be	VBG
cord-002530-ao7kenbx	72	5	encoded	encode	VBN
cord-002530-ao7kenbx	72	6	by	by	IN
cord-002530-ao7kenbx	72	7	the	the	DT
cord-002530-ao7kenbx	72	8	same	same	JJ
cord-002530-ao7kenbx	72	9	primary	primary	JJ
cord-002530-ao7kenbx	72	10	transcript	transcript	NN
cord-002530-ao7kenbx	72	11	,	,	,
cord-002530-ao7kenbx	72	12	IE1	ie1	NN
cord-002530-ao7kenbx	72	13	expression	expression	NN
cord-002530-ao7kenbx	72	14	levels	level	NNS
cord-002530-ao7kenbx	72	15	were	be	VBD
cord-002530-ao7kenbx	72	16	higher	high	JJR
cord-002530-ao7kenbx	72	17	relative	relative	JJ
cord-002530-ao7kenbx	72	18	to	to	IN
cord-002530-ao7kenbx	72	19	control	control	NN
cord-002530-ao7kenbx	72	20	cells	cell	NNS
cord-002530-ao7kenbx	72	21	,	,	,
cord-002530-ao7kenbx	72	22	up	up	RB
cord-002530-ao7kenbx	72	23	until	until	IN
cord-002530-ao7kenbx	72	24	day	day	NN
cord-002530-ao7kenbx	72	25	four	four	CD
cord-002530-ao7kenbx	72	26	post	post	NN
cord-002530-ao7kenbx	72	27	infection	infection	NN
cord-002530-ao7kenbx	72	28	.	.	.
cord-002530-ao7kenbx	73	1	This	this	DT
cord-002530-ao7kenbx	73	2	data	data	NN
cord-002530-ao7kenbx	73	3	indicates	indicate	VBZ
cord-002530-ao7kenbx	73	4	that	that	IN
cord-002530-ao7kenbx	73	5	VCP	VCP	NNP
cord-002530-ao7kenbx	73	6	expression	expression	NN
cord-002530-ao7kenbx	73	7	is	be	VBZ
cord-002530-ao7kenbx	73	8	required	require	VBN
cord-002530-ao7kenbx	73	9	for	for	IN
cord-002530-ao7kenbx	73	10	the	the	DT
cord-002530-ao7kenbx	73	11	onset	onset	NN
cord-002530-ao7kenbx	73	12	of	of	IN
cord-002530-ao7kenbx	73	13	HCMV	HCMV	NNP
cord-002530-ao7kenbx	73	14	replication	replication	NN
cord-002530-ao7kenbx	73	15	and	and	CC
cord-002530-ao7kenbx	73	16	suggests	suggest	VBZ
cord-002530-ao7kenbx	73	17	knockdown	knockdown	NN
cord-002530-ao7kenbx	73	18	of	of	IN
cord-002530-ao7kenbx	73	19	VCP	VCP	NNP
cord-002530-ao7kenbx	73	20	affects	affect	VBZ
cord-002530-ao7kenbx	73	21	expression	expression	NN
cord-002530-ao7kenbx	73	22	of	of	IN
cord-002530-ao7kenbx	73	23	the	the	DT
cord-002530-ao7kenbx	73	24	major	major	JJ
cord-002530-ao7kenbx	73	25	immediate	immediate	JJ
cord-002530-ao7kenbx	73	26	early	early	JJ
cord-002530-ao7kenbx	73	27	genes	gene	NNS
cord-002530-ao7kenbx	73	28	.	.	.
cord-002530-ao7kenbx	74	1	Because	because	IN
cord-002530-ao7kenbx	74	2	knockdown	knockdown	NN
cord-002530-ao7kenbx	74	3	of	of	IN
cord-002530-ao7kenbx	74	4	VCP	VCP	NNP
cord-002530-ao7kenbx	74	5	resulted	result	VBD
cord-002530-ao7kenbx	74	6	in	in	IN
cord-002530-ao7kenbx	74	7	specific	specific	JJ
cord-002530-ao7kenbx	74	8	loss	loss	NN
cord-002530-ao7kenbx	74	9	of	of	IN
cord-002530-ao7kenbx	74	10	IE2	ie2	NN
cord-002530-ao7kenbx	74	11	but	but	CC
cord-002530-ao7kenbx	74	12	not	not	RB
cord-002530-ao7kenbx	74	13	IE1	ie1	NN
cord-002530-ao7kenbx	74	14	,	,	,
cord-002530-ao7kenbx	74	15	we	-PRON-	PRP
cord-002530-ao7kenbx	74	16	hypothesized	hypothesize	VBD
cord-002530-ao7kenbx	74	17	that	that	IN
cord-002530-ao7kenbx	74	18	VCP	VCP	NNP
cord-002530-ao7kenbx	74	19	may	may	MD
cord-002530-ao7kenbx	74	20	play	play	VB
cord-002530-ao7kenbx	74	21	a	a	DT
cord-002530-ao7kenbx	74	22	role	role	NN
cord-002530-ao7kenbx	74	23	in	in	IN
cord-002530-ao7kenbx	74	24	IE2	ie2	JJ
cord-002530-ao7kenbx	74	25	protein	protein	NN
cord-002530-ao7kenbx	74	26	stability	stability	NN
cord-002530-ao7kenbx	74	27	,	,	,
cord-002530-ao7kenbx	74	28	transcript	transcript	NN
cord-002530-ao7kenbx	74	29	stability	stability	NN
cord-002530-ao7kenbx	74	30	or	or	CC
cord-002530-ao7kenbx	74	31	regulation	regulation	NN
cord-002530-ao7kenbx	74	32	of	of	IN
cord-002530-ao7kenbx	74	33	alternative	alternative	JJ
cord-002530-ao7kenbx	74	34	splicing	splicing	NN
cord-002530-ao7kenbx	74	35	and	and	CC
cord-002530-ao7kenbx	74	36	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	74	37	.	.	.
cord-002530-ao7kenbx	75	1	To	to	TO
cord-002530-ao7kenbx	75	2	determine	determine	VB
cord-002530-ao7kenbx	75	3	whether	whether	IN
cord-002530-ao7kenbx	75	4	VCP	VCP	NNP
cord-002530-ao7kenbx	75	5	was	be	VBD
cord-002530-ao7kenbx	75	6	required	require	VBN
cord-002530-ao7kenbx	75	7	for	for	IN
cord-002530-ao7kenbx	75	8	IE2	ie2	JJ
cord-002530-ao7kenbx	75	9	protein	protein	NN
cord-002530-ao7kenbx	75	10	stability	stability	NN
cord-002530-ao7kenbx	75	11	we	-PRON-	PRP
cord-002530-ao7kenbx	75	12	inhibited	inhibit	VBD
cord-002530-ao7kenbx	75	13	the	the	DT
cord-002530-ao7kenbx	75	14	two	two	CD
cord-002530-ao7kenbx	75	15	main	main	JJ
cord-002530-ao7kenbx	75	16	pathways	pathway	NNS
cord-002530-ao7kenbx	75	17	of	of	IN
cord-002530-ao7kenbx	75	18	protein	protein	NN
cord-002530-ao7kenbx	75	19	degradation	degradation	NN
cord-002530-ao7kenbx	75	20	using	use	VBG
cord-002530-ao7kenbx	75	21	MG132	mg132	NN
cord-002530-ao7kenbx	75	22	(	(	-LRB-
cord-002530-ao7kenbx	75	23	proteasome	proteasome	VBN
cord-002530-ao7kenbx	75	24	inhibitorubiquitin	inhibitorubiquitin	NNP
cord-002530-ao7kenbx	75	25	dependent	dependent	JJ
cord-002530-ao7kenbx	75	26	)	)	-RRB-
cord-002530-ao7kenbx	75	27	and	and	CC
cord-002530-ao7kenbx	75	28	pepstatin	pepstatin	NNP
cord-002530-ao7kenbx	75	29	A	A	NNP
cord-002530-ao7kenbx	75	30	or	or	CC
cord-002530-ao7kenbx	75	31	E64	E64	NNP
cord-002530-ao7kenbx	75	32	(	(	-LRB-
cord-002530-ao7kenbx	75	33	protease	protease	NN
cord-002530-ao7kenbx	75	34	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	75	35	-	-	HYPH
cord-002530-ao7kenbx	75	36	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	75	37	independent	independent	NN
cord-002530-ao7kenbx	75	38	)	)	-RRB-
cord-002530-ao7kenbx	75	39	in	in	IN
cord-002530-ao7kenbx	75	40	the	the	DT
cord-002530-ao7kenbx	75	41	context	context	NN
cord-002530-ao7kenbx	75	42	of	of	IN
cord-002530-ao7kenbx	75	43	VCP	VCP	NNP
cord-002530-ao7kenbx	75	44	knockdown	knockdown	NN
cord-002530-ao7kenbx	75	45	(	(	-LRB-
cord-002530-ao7kenbx	75	46	Fig	Fig	NNP
cord-002530-ao7kenbx	75	47	4A	4a	CD
cord-002530-ao7kenbx	75	48	)	)	-RRB-
cord-002530-ao7kenbx	75	49	.	.	.
cord-002530-ao7kenbx	76	1	If	if	IN
cord-002530-ao7kenbx	76	2	VCP	VCP	NNP
cord-002530-ao7kenbx	76	3	regulation	regulation	NN
cord-002530-ao7kenbx	76	4	of	of	IN
cord-002530-ao7kenbx	76	5	IE2	ie2	NN
cord-002530-ao7kenbx	76	6	was	be	VBD
cord-002530-ao7kenbx	76	7	due	due	JJ
cord-002530-ao7kenbx	76	8	to	to	IN
cord-002530-ao7kenbx	76	9	protein	protein	NN
cord-002530-ao7kenbx	76	10	degradation	degradation	NN
cord-002530-ao7kenbx	76	11	,	,	,
cord-002530-ao7kenbx	76	12	inhibition	inhibition	NN
cord-002530-ao7kenbx	76	13	of	of	IN
cord-002530-ao7kenbx	76	14	these	these	DT
cord-002530-ao7kenbx	76	15	pathways	pathway	NNS
cord-002530-ao7kenbx	76	16	should	should	MD
cord-002530-ao7kenbx	76	17	rescue	rescue	VB
cord-002530-ao7kenbx	76	18	IE2	ie2	NN
cord-002530-ao7kenbx	76	19	protein	protein	NN
cord-002530-ao7kenbx	76	20	levels	level	NNS
cord-002530-ao7kenbx	76	21	.	.	.
cord-002530-ao7kenbx	77	1	Neither	neither	CC
cord-002530-ao7kenbx	77	2	MG132	MG132	NNP
cord-002530-ao7kenbx	77	3	,	,	,
cord-002530-ao7kenbx	77	4	pepstatin	pepstatin	NNP
cord-002530-ao7kenbx	77	5	A	A	NNP
cord-002530-ao7kenbx	77	6	,	,	,
cord-002530-ao7kenbx	77	7	nor	nor	CC
cord-002530-ao7kenbx	77	8	E64	E64	NNP
cord-002530-ao7kenbx	77	9	rescued	rescue	VBD
cord-002530-ao7kenbx	77	10	the	the	DT
cord-002530-ao7kenbx	77	11	loss	loss	NN
cord-002530-ao7kenbx	77	12	of	of	IN
cord-002530-ao7kenbx	77	13	IE2	ie2	JJ
cord-002530-ao7kenbx	77	14	proteins	protein	NNS
cord-002530-ao7kenbx	77	15	levels	level	NNS
cord-002530-ao7kenbx	77	16	following	follow	VBG
cord-002530-ao7kenbx	77	17	knockdown	knockdown	NN
cord-002530-ao7kenbx	77	18	of	of	IN
cord-002530-ao7kenbx	77	19	VCP	VCP	NNP
cord-002530-ao7kenbx	77	20	.	.	.
cord-002530-ao7kenbx	78	1	Instead	instead	RB
cord-002530-ao7kenbx	78	2	,	,	,
cord-002530-ao7kenbx	78	3	higher	high	JJR
cord-002530-ao7kenbx	78	4	concentrations	concentration	NNS
cord-002530-ao7kenbx	78	5	of	of	IN
cord-002530-ao7kenbx	78	6	MG132	mg132	NN
cord-002530-ao7kenbx	78	7	phenocopied	phenocopied	JJ
cord-002530-ao7kenbx	78	8	VCP	VCP	NNP
cord-002530-ao7kenbx	78	9	knockdown	knockdown	NN
cord-002530-ao7kenbx	78	10	in	in	IN
cord-002530-ao7kenbx	78	11	control	control	NN
cord-002530-ao7kenbx	78	12	cells	cell	NNS
cord-002530-ao7kenbx	78	13	,	,	,
cord-002530-ao7kenbx	78	14	indicating	indicate	VBG
cord-002530-ao7kenbx	78	15	that	that	IN
cord-002530-ao7kenbx	78	16	proteosomal	proteosomal	JJ
cord-002530-ao7kenbx	78	17	function	function	NN
cord-002530-ao7kenbx	78	18	is	be	VBZ
cord-002530-ao7kenbx	78	19	required	require	VBN
cord-002530-ao7kenbx	78	20	for	for	IN
cord-002530-ao7kenbx	78	21	IE2	ie2	NN
cord-002530-ao7kenbx	78	22	but	but	CC
cord-002530-ao7kenbx	78	23	not	not	RB
cord-002530-ao7kenbx	78	24	IE1	ie1	NN
cord-002530-ao7kenbx	78	25	gene	gene	NN
cord-002530-ao7kenbx	78	26	expression	expression	NN
cord-002530-ao7kenbx	78	27	.	.	.
cord-002530-ao7kenbx	79	1	As	as	IN
cord-002530-ao7kenbx	79	2	VCP	VCP	NNP
cord-002530-ao7kenbx	79	3	targets	target	NNS
cord-002530-ao7kenbx	79	4	ubiquitinated	ubiquitinate	VBD
cord-002530-ao7kenbx	79	5	proteins	protein	NNS
cord-002530-ao7kenbx	79	6	for	for	IN
cord-002530-ao7kenbx	79	7	proteosomal	proteosomal	JJ
cord-002530-ao7kenbx	79	8	degradation	degradation	NN
cord-002530-ao7kenbx	79	9	,	,	,
cord-002530-ao7kenbx	79	10	this	this	DT
cord-002530-ao7kenbx	79	11	result	result	NN
cord-002530-ao7kenbx	79	12	suggests	suggest	VBZ
cord-002530-ao7kenbx	79	13	that	that	IN
cord-002530-ao7kenbx	79	14	an	an	DT
cord-002530-ao7kenbx	79	15	intermediate	intermediate	JJ
cord-002530-ao7kenbx	79	16	protein	protein	NN
cord-002530-ao7kenbx	79	17	,	,	,
cord-002530-ao7kenbx	79	18	targeted	target	VBN
cord-002530-ao7kenbx	79	19	by	by	IN
cord-002530-ao7kenbx	79	20	VCP	VCP	NNP
cord-002530-ao7kenbx	79	21	,	,	,
cord-002530-ao7kenbx	79	22	may	may	MD
cord-002530-ao7kenbx	79	23	inhibit	inhibit	VB
cord-002530-ao7kenbx	79	24	IE2	ie2	JJ
cord-002530-ao7kenbx	79	25	expression	expression	NN
cord-002530-ao7kenbx	79	26	and	and	CC
cord-002530-ao7kenbx	79	27	is	be	VBZ
cord-002530-ao7kenbx	79	28	consistent	consistent	JJ
cord-002530-ao7kenbx	79	29	with	with	IN
cord-002530-ao7kenbx	79	30	previous	previous	JJ
cord-002530-ao7kenbx	79	31	publications	publication	NNS
cord-002530-ao7kenbx	79	32	showing	show	VBG
cord-002530-ao7kenbx	79	33	inhibition	inhibition	NN
cord-002530-ao7kenbx	79	34	of	of	IN
cord-002530-ao7kenbx	79	35	the	the	DT
cord-002530-ao7kenbx	79	36	proteasome	proteasome	NN
cord-002530-ao7kenbx	79	37	reducing	reduce	VBG
cord-002530-ao7kenbx	79	38	IE2	ie2	JJ
cord-002530-ao7kenbx	79	39	expression	expression	NN
cord-002530-ao7kenbx	79	40	and	and	CC
cord-002530-ao7kenbx	79	41	HCMV	HCMV	NNP
cord-002530-ao7kenbx	79	42	replication	replication	NN
cord-002530-ao7kenbx	79	43	[	[	-LRB-
cord-002530-ao7kenbx	79	44	30	30	CD
cord-002530-ao7kenbx	79	45	]	]	-RRB-
cord-002530-ao7kenbx	79	46	.	.	.
cord-002530-ao7kenbx	80	1	To	to	TO
cord-002530-ao7kenbx	80	2	determine	determine	VB
cord-002530-ao7kenbx	80	3	whether	whether	IN
cord-002530-ao7kenbx	80	4	regulation	regulation	NN
cord-002530-ao7kenbx	80	5	of	of	IN
cord-002530-ao7kenbx	80	6	the	the	DT
cord-002530-ao7kenbx	80	7	MIE	MIE	NNP
cord-002530-ao7kenbx	80	8	genes	gene	NNS
cord-002530-ao7kenbx	80	9	was	be	VBD
cord-002530-ao7kenbx	80	10	occurring	occur	VBG
cord-002530-ao7kenbx	80	11	at	at	IN
cord-002530-ao7kenbx	80	12	the	the	DT
cord-002530-ao7kenbx	80	13	RNA	RNA	NNP
cord-002530-ao7kenbx	80	14	level	level	NN
cord-002530-ao7kenbx	80	15	,	,	,
cord-002530-ao7kenbx	80	16	Northern	northern	JJ
cord-002530-ao7kenbx	80	17	blot	blot	NN
cord-002530-ao7kenbx	80	18	analysis	analysis	NN
cord-002530-ao7kenbx	80	19	was	be	VBD
cord-002530-ao7kenbx	80	20	performed	perform	VBN
cord-002530-ao7kenbx	80	21	.	.	.
cord-002530-ao7kenbx	81	1	Fibroblast	Fibroblast	NNP
cord-002530-ao7kenbx	81	2	cells	cell	NNS
cord-002530-ao7kenbx	81	3	transfected	transfecte	VBN
cord-002530-ao7kenbx	81	4	with	with	IN
cord-002530-ao7kenbx	81	5	siRNA	siRNA	NNP
cord-002530-ao7kenbx	81	6	against	against	IN
cord-002530-ao7kenbx	81	7	VCP	VCP	NNP
cord-002530-ao7kenbx	81	8	or	or	CC
cord-002530-ao7kenbx	81	9	control	control	NN
cord-002530-ao7kenbx	81	10	siRNA	siRNA	NNP
cord-002530-ao7kenbx	81	11	were	be	VBD
cord-002530-ao7kenbx	81	12	infected	infect	VBN
cord-002530-ao7kenbx	81	13	48h	48h	CD
cord-002530-ao7kenbx	81	14	post	post	NN
cord-002530-ao7kenbx	81	15	transfection	transfection	NN
cord-002530-ao7kenbx	81	16	at	at	IN
cord-002530-ao7kenbx	81	17	high	high	JJ
cord-002530-ao7kenbx	81	18	MOI	MOI	NNP
cord-002530-ao7kenbx	81	19	with	with	IN
cord-002530-ao7kenbx	81	20	TB40E	tb40e	NN
cord-002530-ao7kenbx	81	21	and	and	CC
cord-002530-ao7kenbx	81	22	total	total	JJ
cord-002530-ao7kenbx	81	23	RNA	RNA	NNP
cord-002530-ao7kenbx	81	24	harvested	harvest	VBN
cord-002530-ao7kenbx	81	25	at	at	IN
cord-002530-ao7kenbx	81	26	24	24	CD
cord-002530-ao7kenbx	81	27	,	,	,
cord-002530-ao7kenbx	81	28	48	48	CD
cord-002530-ao7kenbx	81	29	and	and	CC
cord-002530-ao7kenbx	81	30	72	72	CD
cord-002530-ao7kenbx	81	31	HPI	HPI	NNP
cord-002530-ao7kenbx	81	32	.	.	.
cord-002530-ao7kenbx	82	1	As	as	IN
cord-002530-ao7kenbx	82	2	shown	show	VBN
cord-002530-ao7kenbx	82	3	in	in	IN
cord-002530-ao7kenbx	82	4	Fig	Fig	NNP
cord-002530-ao7kenbx	82	5	4B	4b	NN
cord-002530-ao7kenbx	82	6	,	,	,
cord-002530-ao7kenbx	82	7	knockdown	knockdown	NN
cord-002530-ao7kenbx	82	8	of	of	IN
cord-002530-ao7kenbx	82	9	VCP	VCP	NNP
cord-002530-ao7kenbx	82	10	resulted	result	VBD
cord-002530-ao7kenbx	82	11	in	in	IN
cord-002530-ao7kenbx	82	12	a	a	DT
cord-002530-ao7kenbx	82	13	substantial	substantial	JJ
cord-002530-ao7kenbx	82	14	reduction	reduction	NN
cord-002530-ao7kenbx	82	15	of	of	IN
cord-002530-ao7kenbx	82	16	IE2	IE2	NNP
cord-002530-ao7kenbx	82	17	RNA	RNA	NNP
cord-002530-ao7kenbx	82	18	levels	level	NNS
cord-002530-ao7kenbx	82	19	at	at	IN
cord-002530-ao7kenbx	82	20	48	48	CD
cord-002530-ao7kenbx	82	21	and	and	CC
cord-002530-ao7kenbx	82	22	72	72	CD
cord-002530-ao7kenbx	82	23	HPI	HPI	NNP
cord-002530-ao7kenbx	82	24	,	,	,
cord-002530-ao7kenbx	82	25	including	include	VBG
cord-002530-ao7kenbx	82	26	the	the	DT
cord-002530-ao7kenbx	82	27	smaller	small	JJR
cord-002530-ao7kenbx	82	28	IE60	IE60	NNP
cord-002530-ao7kenbx	82	29	and	and	CC
cord-002530-ao7kenbx	82	30	IE40	IE40	NNP
cord-002530-ao7kenbx	82	31	species	specie	NNS
cord-002530-ao7kenbx	82	32	.	.	.
cord-002530-ao7kenbx	83	1	This	this	DT
cord-002530-ao7kenbx	83	2	result	result	NN
cord-002530-ao7kenbx	83	3	was	be	VBD
cord-002530-ao7kenbx	83	4	confirmed	confirm	VBN
cord-002530-ao7kenbx	83	5	by	by	IN
cord-002530-ao7kenbx	83	6	qRT	qRT	NNP
cord-002530-ao7kenbx	83	7	-	-	HYPH
cord-002530-ao7kenbx	83	8	PCR	PCR	NNP
cord-002530-ao7kenbx	83	9	,	,	,
cord-002530-ao7kenbx	83	10	using	use	VBG
cord-002530-ao7kenbx	83	11	primers	primer	NNS
cord-002530-ao7kenbx	83	12	specific	specific	JJ
cord-002530-ao7kenbx	83	13	for	for	IN
cord-002530-ao7kenbx	83	14	IE1	IE1	NNP
cord-002530-ao7kenbx	83	15	and	and	CC
cord-002530-ao7kenbx	83	16	IE2	IE2	NNP
cord-002530-ao7kenbx	83	17	transcript	transcript	NN
cord-002530-ao7kenbx	83	18	.	.	.
cord-002530-ao7kenbx	84	1	Supplemental	Supplemental	NNP
cord-002530-ao7kenbx	84	2	Fig	Fig	NNP
cord-002530-ao7kenbx	84	3	2A	2a	NN
cord-002530-ao7kenbx	84	4	demonstrates	demonstrate	VBZ
cord-002530-ao7kenbx	84	5	the	the	DT
cord-002530-ao7kenbx	84	6	clear	clear	JJ
cord-002530-ao7kenbx	84	7	difference	difference	NN
cord-002530-ao7kenbx	84	8	in	in	IN
cord-002530-ao7kenbx	84	9	the	the	DT
cord-002530-ao7kenbx	84	10	kinetics	kinetic	NNS
cord-002530-ao7kenbx	84	11	of	of	IN
cord-002530-ao7kenbx	84	12	IE1	IE1	NNP
cord-002530-ao7kenbx	84	13	and	and	CC
cord-002530-ao7kenbx	84	14	IE2	IE2	NNP
cord-002530-ao7kenbx	84	15	transcript	transcript	NN
cord-002530-ao7kenbx	84	16	accumulation	accumulation	NN
cord-002530-ao7kenbx	84	17	in	in	IN
cord-002530-ao7kenbx	84	18	control	control	NN
cord-002530-ao7kenbx	84	19	cells	cell	NNS
cord-002530-ao7kenbx	84	20	,	,	,
cord-002530-ao7kenbx	84	21	with	with	IN
cord-002530-ao7kenbx	84	22	IE1	ie1	NN
cord-002530-ao7kenbx	84	23	transcript	transcript	NN
cord-002530-ao7kenbx	84	24	levels	level	NNS
cord-002530-ao7kenbx	84	25	rapidly	rapidly	RB
cord-002530-ao7kenbx	84	26	increasing	increase	VBG
cord-002530-ao7kenbx	84	27	following	follow	VBG
cord-002530-ao7kenbx	84	28	infection	infection	NN
cord-002530-ao7kenbx	84	29	,	,	,
cord-002530-ao7kenbx	84	30	while	while	IN
cord-002530-ao7kenbx	84	31	IE2	ie2	JJ
cord-002530-ao7kenbx	84	32	levels	level	NNS
cord-002530-ao7kenbx	84	33	initially	initially	RB
cord-002530-ao7kenbx	84	34	increase	increase	VBP
cord-002530-ao7kenbx	84	35	,	,	,
cord-002530-ao7kenbx	84	36	then	then	RB
cord-002530-ao7kenbx	84	37	plateau	plateau	NN
cord-002530-ao7kenbx	84	38	between	between	IN
cord-002530-ao7kenbx	84	39	12	12	CD
cord-002530-ao7kenbx	84	40	and	and	CC
cord-002530-ao7kenbx	84	41	24	24	CD
cord-002530-ao7kenbx	84	42	HPI	HPI	NNP
cord-002530-ao7kenbx	84	43	,	,	,
cord-002530-ao7kenbx	84	44	before	before	IN
cord-002530-ao7kenbx	84	45	accumulating	accumulate	VBG
cord-002530-ao7kenbx	84	46	to	to	IN
cord-002530-ao7kenbx	84	47	substantially	substantially	RB
cord-002530-ao7kenbx	84	48	higher	high	JJR
cord-002530-ao7kenbx	84	49	levels	level	NNS
cord-002530-ao7kenbx	84	50	from	from	IN
cord-002530-ao7kenbx	84	51	24	24	CD
cord-002530-ao7kenbx	84	52	HPI	HPI	NNP
cord-002530-ao7kenbx	84	53	onwards	onwards	RB
cord-002530-ao7kenbx	84	54	.	.	.
cord-002530-ao7kenbx	85	1	This	this	DT
cord-002530-ao7kenbx	85	2	accumulation	accumulation	NN
cord-002530-ao7kenbx	85	3	fails	fail	VBZ
cord-002530-ao7kenbx	85	4	to	to	TO
cord-002530-ao7kenbx	85	5	occur	occur	VB
cord-002530-ao7kenbx	85	6	following	follow	VBG
cord-002530-ao7kenbx	85	7	knockdown	knockdown	NN
cord-002530-ao7kenbx	85	8	of	of	IN
cord-002530-ao7kenbx	85	9	VCP	VCP	NNP
cord-002530-ao7kenbx	85	10	,	,	,
cord-002530-ao7kenbx	85	11	where	where	WRB
cord-002530-ao7kenbx	85	12	levels	level	NNS
cord-002530-ao7kenbx	85	13	of	of	IN
cord-002530-ao7kenbx	85	14	IE2	ie2	NN
cord-002530-ao7kenbx	85	15	do	do	VBP
cord-002530-ao7kenbx	85	16	not	not	RB
cord-002530-ao7kenbx	85	17	substantially	substantially	RB
cord-002530-ao7kenbx	85	18	increase	increase	VB
cord-002530-ao7kenbx	85	19	after	after	IN
cord-002530-ao7kenbx	85	20	24	24	CD
cord-002530-ao7kenbx	85	21	HPI	HPI	NNP
cord-002530-ao7kenbx	85	22	,	,	,
cord-002530-ao7kenbx	85	23	in	in	IN
cord-002530-ao7kenbx	85	24	contrast	contrast	NN
cord-002530-ao7kenbx	85	25	to	to	TO
cord-002530-ao7kenbx	85	26	control	control	NN
cord-002530-ao7kenbx	85	27	cells	cell	NNS
cord-002530-ao7kenbx	85	28	(	(	-LRB-
cord-002530-ao7kenbx	85	29	S2B	S2B	NNS
cord-002530-ao7kenbx	85	30	and	and	CC
cord-002530-ao7kenbx	85	31	S2D	S2D	NNP
cord-002530-ao7kenbx	85	32	Fig	Fig	NNP
cord-002530-ao7kenbx	85	33	)	)	-RRB-
cord-002530-ao7kenbx	85	34	.	.	.
cord-002530-ao7kenbx	86	1	MIE	MIE	NNP
cord-002530-ao7kenbx	86	2	transcription	transcription	NN
cord-002530-ao7kenbx	86	3	is	be	VBZ
cord-002530-ao7kenbx	86	4	also	also	RB
cord-002530-ao7kenbx	86	5	affected	affect	VBN
cord-002530-ao7kenbx	86	6	at	at	IN
cord-002530-ao7kenbx	86	7	earlier	early	JJR
cord-002530-ao7kenbx	86	8	time	time	NN
cord-002530-ao7kenbx	86	9	points	point	NNS
cord-002530-ao7kenbx	86	10	with	with	IN
cord-002530-ao7kenbx	86	11	levels	level	NNS
cord-002530-ao7kenbx	86	12	of	of	IN
cord-002530-ao7kenbx	86	13	both	both	CC
cord-002530-ao7kenbx	86	14	IE1	ie1	NN
cord-002530-ao7kenbx	86	15	and	and	CC
cord-002530-ao7kenbx	86	16	IE2	ie2	NN
cord-002530-ao7kenbx	86	17	reduced	reduce	VBN
cord-002530-ao7kenbx	86	18	at	at	IN
cord-002530-ao7kenbx	86	19	6	6	CD
cord-002530-ao7kenbx	86	20	HPI	HPI	NNP
cord-002530-ao7kenbx	86	21	and	and	CC
cord-002530-ao7kenbx	86	22	increased	increase	VBD
cord-002530-ao7kenbx	86	23	at	at	IN
cord-002530-ao7kenbx	86	24	24	24	CD
cord-002530-ao7kenbx	86	25	HPI	HPI	NNP
cord-002530-ao7kenbx	86	26	(	(	-LRB-
cord-002530-ao7kenbx	86	27	S2C	S2C	NNP
cord-002530-ao7kenbx	86	28	and	and	CC
cord-002530-ao7kenbx	86	29	S2D	S2D	NNP
cord-002530-ao7kenbx	86	30	Fig	Fig	NNP
cord-002530-ao7kenbx	86	31	)	)	-RRB-
cord-002530-ao7kenbx	86	32	.	.	.
cord-002530-ao7kenbx	87	1	An	an	DT
cord-002530-ao7kenbx	87	2	increase	increase	NN
cord-002530-ao7kenbx	87	3	in	in	IN
cord-002530-ao7kenbx	87	4	IE1	IE1	NNP
cord-002530-ao7kenbx	87	5	and	and	CC
cord-002530-ao7kenbx	87	6	IE2	IE2	NNP
cord-002530-ao7kenbx	87	7	RNA	RNA	NNP
cord-002530-ao7kenbx	87	8	levels	level	NNS
cord-002530-ao7kenbx	87	9	at	at	IN
cord-002530-ao7kenbx	87	10	24	24	CD
cord-002530-ao7kenbx	87	11	HPI	HPI	NNP
cord-002530-ao7kenbx	87	12	may	may	MD
cord-002530-ao7kenbx	87	13	be	be	VB
cord-002530-ao7kenbx	87	14	a	a	DT
cord-002530-ao7kenbx	87	15	result	result	NN
cord-002530-ao7kenbx	87	16	of	of	IN
cord-002530-ao7kenbx	87	17	increased	increase	VBN
cord-002530-ao7kenbx	87	18	MIE	MIE	NNP
cord-002530-ao7kenbx	87	19	promoter	promoter	NN
cord-002530-ao7kenbx	87	20	activity	activity	NN
cord-002530-ao7kenbx	87	21	due	due	IN
cord-002530-ao7kenbx	87	22	to	to	IN
cord-002530-ao7kenbx	87	23	the	the	DT
cord-002530-ao7kenbx	87	24	associated	associate	VBN
cord-002530-ao7kenbx	87	25	loss	loss	NN
cord-002530-ao7kenbx	87	26	of	of	IN
cord-002530-ao7kenbx	87	27	IE2	ie2	JJ
cord-002530-ao7kenbx	87	28	protein	protein	NN
cord-002530-ao7kenbx	87	29	expression	expression	NN
cord-002530-ao7kenbx	87	30	at	at	IN
cord-002530-ao7kenbx	87	31	early	early	JJ
cord-002530-ao7kenbx	87	32	time	time	NN
cord-002530-ao7kenbx	87	33	points	point	NNS
cord-002530-ao7kenbx	87	34	,	,	,
cord-002530-ao7kenbx	87	35	as	as	IN
cord-002530-ao7kenbx	87	36	IE2	ie2	NN
cord-002530-ao7kenbx	87	37	is	be	VBZ
cord-002530-ao7kenbx	87	38	a	a	DT
cord-002530-ao7kenbx	87	39	negative	negative	JJ
cord-002530-ao7kenbx	87	40	regulator	regulator	NN
cord-002530-ao7kenbx	87	41	of	of	IN
cord-002530-ao7kenbx	87	42	the	the	DT
cord-002530-ao7kenbx	87	43	MIE	MIE	NNP
cord-002530-ao7kenbx	87	44	promoter	promoter	NN
cord-002530-ao7kenbx	87	45	.	.	.
cord-002530-ao7kenbx	88	1	IE1	ie1	NN
cord-002530-ao7kenbx	88	2	transcript	transcript	NN
cord-002530-ao7kenbx	88	3	levels	level	NNS
cord-002530-ao7kenbx	88	4	decrease	decrease	VBP
cord-002530-ao7kenbx	88	5	rapidly	rapidly	RB
cord-002530-ao7kenbx	88	6	24	24	CD
cord-002530-ao7kenbx	88	7	to	to	IN
cord-002530-ao7kenbx	88	8	48	48	CD
cord-002530-ao7kenbx	88	9	HPI	HPI	NNP
cord-002530-ao7kenbx	88	10	,	,	,
cord-002530-ao7kenbx	88	11	while	while	IN
cord-002530-ao7kenbx	88	12	protein	protein	NN
cord-002530-ao7kenbx	88	13	levels	level	NNS
cord-002530-ao7kenbx	88	14	remain	remain	VBP
cord-002530-ao7kenbx	88	15	high	high	JJ
cord-002530-ao7kenbx	88	16	,	,	,
cord-002530-ao7kenbx	88	17	suggesting	suggest	VBG
cord-002530-ao7kenbx	88	18	that	that	IN
cord-002530-ao7kenbx	88	19	IE1	ie1	NN
cord-002530-ao7kenbx	88	20	protein	protein	NN
cord-002530-ao7kenbx	88	21	is	be	VBZ
cord-002530-ao7kenbx	88	22	stable	stable	JJ
cord-002530-ao7kenbx	88	23	and	and	CC
cord-002530-ao7kenbx	88	24	the	the	DT
cord-002530-ao7kenbx	88	25	increase	increase	NN
cord-002530-ao7kenbx	88	26	in	in	IN
cord-002530-ao7kenbx	88	27	IE1	ie1	NN
cord-002530-ao7kenbx	88	28	transcription	transcription	NN
cord-002530-ao7kenbx	88	29	at	at	IN
cord-002530-ao7kenbx	88	30	24	24	CD
cord-002530-ao7kenbx	88	31	hours	hour	NNS
cord-002530-ao7kenbx	88	32	may	may	MD
cord-002530-ao7kenbx	88	33	contribute	contribute	VB
cord-002530-ao7kenbx	88	34	to	to	IN
cord-002530-ao7kenbx	88	35	the	the	DT
cord-002530-ao7kenbx	88	36	prolonged	prolonged	JJ
cord-002530-ao7kenbx	88	37	increase	increase	NN
cord-002530-ao7kenbx	88	38	in	in	IN
cord-002530-ao7kenbx	88	39	IE1	ie1	NN
cord-002530-ao7kenbx	88	40	protein	protein	NN
cord-002530-ao7kenbx	88	41	levels	level	NNS
cord-002530-ao7kenbx	88	42	.	.	.
cord-002530-ao7kenbx	89	1	These	these	DT
cord-002530-ao7kenbx	89	2	results	result	NNS
cord-002530-ao7kenbx	89	3	suggest	suggest	VBP
cord-002530-ao7kenbx	89	4	that	that	IN
cord-002530-ao7kenbx	89	5	VCP	VCP	NNP
cord-002530-ao7kenbx	89	6	may	may	MD
cord-002530-ao7kenbx	89	7	be	be	VB
cord-002530-ao7kenbx	89	8	affecting	affect	VBG
cord-002530-ao7kenbx	89	9	other	other	JJ
cord-002530-ao7kenbx	89	10	aspects	aspect	NNS
cord-002530-ao7kenbx	89	11	of	of	IN
cord-002530-ao7kenbx	89	12	MIE	MIE	NNP
cord-002530-ao7kenbx	89	13	transcription	transcription	NN
cord-002530-ao7kenbx	89	14	.	.	.
cord-002530-ao7kenbx	90	1	However	however	RB
cord-002530-ao7kenbx	90	2	,	,	,
cord-002530-ao7kenbx	90	3	Northern	northern	JJ
cord-002530-ao7kenbx	90	4	,	,	,
cord-002530-ao7kenbx	90	5	Western	western	JJ
cord-002530-ao7kenbx	90	6	and	and	CC
cord-002530-ao7kenbx	90	7	qRT	qRT	NNP
cord-002530-ao7kenbx	90	8	-	-	HYPH
cord-002530-ao7kenbx	90	9	PCR	PCR	NNP
cord-002530-ao7kenbx	90	10	data	datum	NNS
cord-002530-ao7kenbx	90	11	are	be	VBP
cord-002530-ao7kenbx	90	12	all	all	DT
cord-002530-ao7kenbx	90	13	consistent	consistent	JJ
cord-002530-ao7kenbx	90	14	with	with	IN
cord-002530-ao7kenbx	90	15	a	a	DT
cord-002530-ao7kenbx	90	16	substantial	substantial	JJ
cord-002530-ao7kenbx	90	17	effect	effect	NN
cord-002530-ao7kenbx	90	18	on	on	IN
cord-002530-ao7kenbx	90	19	IE2	ie2	JJ
cord-002530-ao7kenbx	90	20	expression	expression	NN
cord-002530-ao7kenbx	90	21	from	from	IN
cord-002530-ao7kenbx	90	22	24	24	CD
cord-002530-ao7kenbx	90	23	HPI	HPI	NNP
cord-002530-ao7kenbx	90	24	onwards	onwards	RB
cord-002530-ao7kenbx	90	25	.	.	.
cord-002530-ao7kenbx	90	26	 	 	_SP
cord-002530-ao7kenbx	91	1	To	to	TO
cord-002530-ao7kenbx	91	2	determine	determine	VB
cord-002530-ao7kenbx	91	3	whether	whether	IN
cord-002530-ao7kenbx	91	4	loss	loss	NN
cord-002530-ao7kenbx	91	5	of	of	IN
cord-002530-ao7kenbx	91	6	VCP	vcp	NN
cord-002530-ao7kenbx	91	7	results	result	NNS
cord-002530-ao7kenbx	91	8	in	in	IN
cord-002530-ao7kenbx	91	9	specific	specific	JJ
cord-002530-ao7kenbx	91	10	destabilization	destabilization	NN
cord-002530-ao7kenbx	91	11	of	of	IN
cord-002530-ao7kenbx	91	12	IE2	IE2	NNP
cord-002530-ao7kenbx	91	13	transcript	transcript	NN
cord-002530-ao7kenbx	91	14	,	,	,
cord-002530-ao7kenbx	91	15	RNA	RNA	NNP
cord-002530-ao7kenbx	91	16	levels	level	NNS
cord-002530-ao7kenbx	91	17	were	be	VBD
cord-002530-ao7kenbx	91	18	measured	measure	VBN
cord-002530-ao7kenbx	91	19	following	follow	VBG
cord-002530-ao7kenbx	91	20	treatment	treatment	NN
cord-002530-ao7kenbx	91	21	of	of	IN
cord-002530-ao7kenbx	91	22	cells	cell	NNS
cord-002530-ao7kenbx	91	23	with	with	IN
cord-002530-ao7kenbx	91	24	actinomycin	actinomycin	NNS
cord-002530-ao7kenbx	91	25	D	D	NNP
cord-002530-ao7kenbx	91	26	48	48	CD
cord-002530-ao7kenbx	91	27	HPI	HPI	NNP
cord-002530-ao7kenbx	91	28	.	.	.
cord-002530-ao7kenbx	92	1	Actinomycin	Actinomycin	NNP
cord-002530-ao7kenbx	92	2	D	D	NNP
cord-002530-ao7kenbx	92	3	inhibits	inhibit	VBZ
cord-002530-ao7kenbx	92	4	RNA	rna	NN
cord-002530-ao7kenbx	92	5	polymerase	polymerase	NN
cord-002530-ao7kenbx	92	6	,	,	,
cord-002530-ao7kenbx	92	7	blocking	block	VBG
cord-002530-ao7kenbx	92	8	new	new	JJ
cord-002530-ao7kenbx	92	9	transcription	transcription	NN
cord-002530-ao7kenbx	92	10	of	of	IN
cord-002530-ao7kenbx	92	11	IE1	ie1	NN
cord-002530-ao7kenbx	92	12	and	and	CC
cord-002530-ao7kenbx	92	13	IE2	IE2	NNP
cord-002530-ao7kenbx	92	14	,	,	,
cord-002530-ao7kenbx	92	15	allowing	allow	VBG
cord-002530-ao7kenbx	92	16	for	for	IN
cord-002530-ao7kenbx	92	17	monitoring	monitoring	NN
cord-002530-ao7kenbx	92	18	of	of	IN
cord-002530-ao7kenbx	92	19	transcript	transcript	NN
cord-002530-ao7kenbx	92	20	stability	stability	NN
cord-002530-ao7kenbx	92	21	over	over	IN
cord-002530-ao7kenbx	92	22	time	time	NN
cord-002530-ao7kenbx	92	23	.	.	.
cord-002530-ao7kenbx	93	1	Total	Total	NNP
cord-002530-ao7kenbx	93	2	RNA	RNA	NNP
cord-002530-ao7kenbx	93	3	was	be	VBD
cord-002530-ao7kenbx	93	4	harvested	harvest	VBN
cord-002530-ao7kenbx	93	5	at	at	IN
cord-002530-ao7kenbx	93	6	the	the	DT
cord-002530-ao7kenbx	93	7	indicated	indicate	VBN
cord-002530-ao7kenbx	93	8	time	time	NN
cord-002530-ao7kenbx	93	9	points	point	NNS
cord-002530-ao7kenbx	93	10	and	and	CC
cord-002530-ao7kenbx	93	11	IE1	ie1	NN
cord-002530-ao7kenbx	93	12	and	and	CC
cord-002530-ao7kenbx	93	13	IE2	ie2	JJ
cord-002530-ao7kenbx	93	14	transcript	transcript	NN
cord-002530-ao7kenbx	93	15	levels	level	NNS
cord-002530-ao7kenbx	93	16	determined	determine	VBN
cord-002530-ao7kenbx	93	17	by	by	IN
cord-002530-ao7kenbx	93	18	Northern	northern	JJ
cord-002530-ao7kenbx	93	19	blot	blot	NN
cord-002530-ao7kenbx	93	20	analysis	analysis	NN
cord-002530-ao7kenbx	93	21	.	.	.
cord-002530-ao7kenbx	94	1	Calculation	calculation	NN
cord-002530-ao7kenbx	94	2	of	of	IN
cord-002530-ao7kenbx	94	3	the	the	DT
cord-002530-ao7kenbx	94	4	half	half	JJ
cord-002530-ao7kenbx	94	5	-	-	HYPH
cord-002530-ao7kenbx	94	6	life	life	NN
cord-002530-ao7kenbx	94	7	of	of	IN
cord-002530-ao7kenbx	94	8	IE1	ie1	NN
cord-002530-ao7kenbx	94	9	and	and	CC
cord-002530-ao7kenbx	94	10	IE2	ie2	JJ
cord-002530-ao7kenbx	94	11	transcripts	transcript	NNS
cord-002530-ao7kenbx	94	12	indicated	indicate	VBD
cord-002530-ao7kenbx	94	13	that	that	IN
cord-002530-ao7kenbx	94	14	stability	stability	NN
cord-002530-ao7kenbx	94	15	of	of	IN
cord-002530-ao7kenbx	94	16	both	both	CC
cord-002530-ao7kenbx	94	17	IE1	ie1	NN
cord-002530-ao7kenbx	94	18	and	and	CC
cord-002530-ao7kenbx	94	19	IE2	ie2	NN
cord-002530-ao7kenbx	94	20	modestly	modestly	RB
cord-002530-ao7kenbx	94	21	increased	increase	VBD
cord-002530-ao7kenbx	94	22	by	by	IN
cord-002530-ao7kenbx	94	23	1.8	1.8	CD
cord-002530-ao7kenbx	94	24	and	and	CC
cord-002530-ao7kenbx	94	25	1.5	1.5	CD
cord-002530-ao7kenbx	94	26	fold	fold	VBP
cord-002530-ao7kenbx	94	27	respectively	respectively	RB
cord-002530-ao7kenbx	94	28	,	,	,
cord-002530-ao7kenbx	94	29	suggesting	suggest	VBG
cord-002530-ao7kenbx	94	30	loss	loss	NN
cord-002530-ao7kenbx	94	31	of	of	IN
cord-002530-ao7kenbx	94	32	VCP	vcp	NN
cord-002530-ao7kenbx	94	33	does	do	VBZ
cord-002530-ao7kenbx	94	34	not	not	RB
cord-002530-ao7kenbx	94	35	result	result	VB
cord-002530-ao7kenbx	94	36	in	in	IN
cord-002530-ao7kenbx	94	37	IE2	ie2	NN
cord-002530-ao7kenbx	94	38	transcript	transcript	NN
cord-002530-ao7kenbx	94	39	destabilization	destabilization	NN
cord-002530-ao7kenbx	94	40	(	(	-LRB-
cord-002530-ao7kenbx	94	41	Fig	Fig	NNP
cord-002530-ao7kenbx	94	42	5	5	CD
cord-002530-ao7kenbx	94	43	)	)	-RRB-
cord-002530-ao7kenbx	94	44	.	.	.
cord-002530-ao7kenbx	95	1	Defining	define	VBG
cord-002530-ao7kenbx	95	2	changes	change	NNS
cord-002530-ao7kenbx	95	3	in	in	IN
cord-002530-ao7kenbx	95	4	alternative	alternative	JJ
cord-002530-ao7kenbx	95	5	splicing	splicing	NN
cord-002530-ao7kenbx	95	6	of	of	IN
cord-002530-ao7kenbx	95	7	IE1	ie1	NN
cord-002530-ao7kenbx	95	8	and	and	CC
cord-002530-ao7kenbx	95	9	IE2	ie2	NN
cord-002530-ao7kenbx	95	10	is	be	VBZ
cord-002530-ao7kenbx	95	11	challenging	challenging	JJ
cord-002530-ao7kenbx	95	12	as	as	IN
cord-002530-ao7kenbx	95	13	multiple	multiple	JJ
cord-002530-ao7kenbx	95	14	factors	factor	NNS
cord-002530-ao7kenbx	95	15	,	,	,
cord-002530-ao7kenbx	95	16	including	include	VBG
cord-002530-ao7kenbx	95	17	promoter	promoter	NN
cord-002530-ao7kenbx	95	18	activity	activity	NN
cord-002530-ao7kenbx	95	19	,	,	,
cord-002530-ao7kenbx	95	20	RNA	RNA	NNP
cord-002530-ao7kenbx	95	21	stability	stability	NN
cord-002530-ao7kenbx	95	22	and	and	CC
cord-002530-ao7kenbx	95	23	viral	viral	JJ
cord-002530-ao7kenbx	95	24	genome	genome	NN
cord-002530-ao7kenbx	95	25	amplification	amplification	NN
cord-002530-ao7kenbx	95	26	can	can	MD
cord-002530-ao7kenbx	95	27	all	all	RB
cord-002530-ao7kenbx	95	28	contribute	contribute	VB
cord-002530-ao7kenbx	95	29	to	to	IN
cord-002530-ao7kenbx	95	30	an	an	DT
cord-002530-ao7kenbx	95	31	increase	increase	NN
cord-002530-ao7kenbx	95	32	or	or	CC
cord-002530-ao7kenbx	95	33	decrease	decrease	NN
cord-002530-ao7kenbx	95	34	in	in	IN
cord-002530-ao7kenbx	95	35	total	total	JJ
cord-002530-ao7kenbx	95	36	IE1	IE1	NNP
cord-002530-ao7kenbx	95	37	and	and	CC
cord-002530-ao7kenbx	95	38	IE2	IE2	NNP
cord-002530-ao7kenbx	95	39	mRNA	mRNA	NNP
cord-002530-ao7kenbx	95	40	levels	level	NNS
cord-002530-ao7kenbx	95	41	.	.	.
cord-002530-ao7kenbx	96	1	To	to	TO
cord-002530-ao7kenbx	96	2	determine	determine	VB
cord-002530-ao7kenbx	96	3	whether	whether	IN
cord-002530-ao7kenbx	96	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	96	5	of	of	IN
cord-002530-ao7kenbx	96	6	VCP	VCP	NNP
cord-002530-ao7kenbx	96	7	altered	alter	VBN
cord-002530-ao7kenbx	96	8	differential	differential	JJ
cord-002530-ao7kenbx	96	9	splicing	splicing	NN
cord-002530-ao7kenbx	96	10	of	of	IN
cord-002530-ao7kenbx	96	11	the	the	DT
cord-002530-ao7kenbx	96	12	MIE	MIE	NNP
cord-002530-ao7kenbx	96	13	region	region	NN
cord-002530-ao7kenbx	96	14	,	,	,
cord-002530-ao7kenbx	96	15	RNAseq	rnaseq	NN
cord-002530-ao7kenbx	96	16	analysis	analysis	NN
cord-002530-ao7kenbx	96	17	was	be	VBD
cord-002530-ao7kenbx	96	18	performed	perform	VBN
cord-002530-ao7kenbx	96	19	.	.	.
cord-002530-ao7kenbx	97	1	This	this	DT
cord-002530-ao7kenbx	97	2	allows	allow	VBZ
cord-002530-ao7kenbx	97	3	a	a	DT
cord-002530-ao7kenbx	97	4	direct	direct	JJ
cord-002530-ao7kenbx	97	5	comparison	comparison	NN
cord-002530-ao7kenbx	97	6	of	of	IN
cord-002530-ao7kenbx	97	7	read	read	NN
cord-002530-ao7kenbx	97	8	counts	count	VBZ
cord-002530-ao7kenbx	97	9	from	from	IN
cord-002530-ao7kenbx	97	10	the	the	DT
cord-002530-ao7kenbx	97	11	first	first	JJ
cord-002530-ao7kenbx	97	12	three	three	CD
cord-002530-ao7kenbx	97	13	shared	share	VBN
cord-002530-ao7kenbx	97	14	exons	exon	NNS
cord-002530-ao7kenbx	97	15	of	of	IN
cord-002530-ao7kenbx	97	16	the	the	DT
cord-002530-ao7kenbx	97	17	MIE	MIE	NNP
cord-002530-ao7kenbx	97	18	transcripts	transcript	NNS
cord-002530-ao7kenbx	97	19	to	to	IN
cord-002530-ao7kenbx	97	20	the	the	DT
cord-002530-ao7kenbx	97	21	IE1	ie1	NN
cord-002530-ao7kenbx	97	22	and	and	CC
cord-002530-ao7kenbx	97	23	IE2	ie2	JJ
cord-002530-ao7kenbx	97	24	specific	specific	JJ
cord-002530-ao7kenbx	97	25	exons	exon	NNS
cord-002530-ao7kenbx	97	26	four	four	CD
cord-002530-ao7kenbx	97	27	and	and	CC
cord-002530-ao7kenbx	97	28	five	five	CD
cord-002530-ao7kenbx	97	29	,	,	,
cord-002530-ao7kenbx	97	30	respectively	respectively	RB
cord-002530-ao7kenbx	97	31	.	.	.
cord-002530-ao7kenbx	98	1	This	this	DT
cord-002530-ao7kenbx	98	2	controls	control	VBZ
cord-002530-ao7kenbx	98	3	for	for	IN
cord-002530-ao7kenbx	98	4	changes	change	NNS
cord-002530-ao7kenbx	98	5	in	in	IN
cord-002530-ao7kenbx	98	6	promoter	promoter	NN
cord-002530-ao7kenbx	98	7	activity	activity	NN
cord-002530-ao7kenbx	98	8	and	and	CC
cord-002530-ao7kenbx	98	9	effects	effect	NNS
cord-002530-ao7kenbx	98	10	of	of	IN
cord-002530-ao7kenbx	98	11	genome	genome	NN
cord-002530-ao7kenbx	98	12	amplification	amplification	NN
cord-002530-ao7kenbx	98	13	.	.	.
cord-002530-ao7kenbx	99	1	Therefore	therefore	RB
cord-002530-ao7kenbx	99	2	,	,	,
cord-002530-ao7kenbx	99	3	based	base	VBN
cord-002530-ao7kenbx	99	4	on	on	IN
cord-002530-ao7kenbx	99	5	our	-PRON-	PRP$
cord-002530-ao7kenbx	99	6	current	current	JJ
cord-002530-ao7kenbx	99	7	understanding	understanding	NN
cord-002530-ao7kenbx	99	8	of	of	IN
cord-002530-ao7kenbx	99	9	RNA	RNA	NNP
cord-002530-ao7kenbx	99	10	processing	processing	NN
cord-002530-ao7kenbx	99	11	,	,	,
cord-002530-ao7kenbx	99	12	changes	change	NNS
cord-002530-ao7kenbx	99	13	in	in	IN
cord-002530-ao7kenbx	99	14	the	the	DT
cord-002530-ao7kenbx	99	15	absolute	absolute	JJ
cord-002530-ao7kenbx	99	16	ratio	ratio	NN
cord-002530-ao7kenbx	99	17	of	of	IN
cord-002530-ao7kenbx	99	18	exon	exon	NN
cord-002530-ao7kenbx	99	19	four	four	CD
cord-002530-ao7kenbx	99	20	or	or	CC
cord-002530-ao7kenbx	99	21	five	five	CD
cord-002530-ao7kenbx	99	22	to	to	IN
cord-002530-ao7kenbx	99	23	the	the	DT
cord-002530-ao7kenbx	99	24	shared	share	VBN
cord-002530-ao7kenbx	99	25	exons	exon	NNS
cord-002530-ao7kenbx	99	26	must	must	MD
cord-002530-ao7kenbx	99	27	be	be	VB
cord-002530-ao7kenbx	99	28	due	due	JJ
cord-002530-ao7kenbx	99	29	to	to	IN
cord-002530-ao7kenbx	99	30	changes	change	NNS
cord-002530-ao7kenbx	99	31	in	in	IN
cord-002530-ao7kenbx	99	32	splicing	splicing	NN
cord-002530-ao7kenbx	99	33	or	or	CC
cord-002530-ao7kenbx	99	34	changes	change	NNS
cord-002530-ao7kenbx	99	35	in	in	IN
cord-002530-ao7kenbx	99	36	RNA	RNA	NNP
cord-002530-ao7kenbx	99	37	stability	stability	NN
cord-002530-ao7kenbx	99	38	.	.	.
cord-002530-ao7kenbx	100	1	Cells	cell	NNS
cord-002530-ao7kenbx	100	2	were	be	VBD
cord-002530-ao7kenbx	100	3	transfected	transfecte	VBN
cord-002530-ao7kenbx	100	4	with	with	IN
cord-002530-ao7kenbx	100	5	VCP	VCP	NNP
cord-002530-ao7kenbx	100	6	siRNA	siRNA	NNP
cord-002530-ao7kenbx	100	7	or	or	CC
cord-002530-ao7kenbx	100	8	a	a	DT
cord-002530-ao7kenbx	100	9	negative	negative	JJ
cord-002530-ao7kenbx	100	10	control	control	NN
cord-002530-ao7kenbx	100	11	siRNA	siRNA	NNP
cord-002530-ao7kenbx	100	12	and	and	CC
cord-002530-ao7kenbx	100	13	infected	infect	VBN
cord-002530-ao7kenbx	100	14	with	with	IN
cord-002530-ao7kenbx	100	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	100	16	at	at	IN
cord-002530-ao7kenbx	100	17	an	an	DT
cord-002530-ao7kenbx	100	18	MOI	MOI	NNP
cord-002530-ao7kenbx	100	19	of	of	IN
cord-002530-ao7kenbx	100	20	three	three	CD
cord-002530-ao7kenbx	100	21	.	.	.
cord-002530-ao7kenbx	101	1	Total	Total	NNP
cord-002530-ao7kenbx	101	2	RNA	RNA	NNP
cord-002530-ao7kenbx	101	3	was	be	VBD
cord-002530-ao7kenbx	101	4	harvested	harvest	VBN
cord-002530-ao7kenbx	101	5	at	at	IN
cord-002530-ao7kenbx	101	6	24	24	CD
cord-002530-ao7kenbx	101	7	,	,	,
cord-002530-ao7kenbx	101	8	48	48	CD
cord-002530-ao7kenbx	101	9	and	and	CC
cord-002530-ao7kenbx	101	10	72	72	CD
cord-002530-ao7kenbx	101	11	HPI	HPI	NNP
cord-002530-ao7kenbx	101	12	and	and	CC
cord-002530-ao7kenbx	101	13	subjected	subject	VBN
cord-002530-ao7kenbx	101	14	to	to	IN
cord-002530-ao7kenbx	101	15	strand	strand	NN
cord-002530-ao7kenbx	101	16	-	-	HYPH
cord-002530-ao7kenbx	101	17	specific	specific	JJ
cord-002530-ao7kenbx	101	18	,	,	,
cord-002530-ao7kenbx	101	19	pairedend	pairedend	NNP
cord-002530-ao7kenbx	101	20	,	,	,
cord-002530-ao7kenbx	101	21	Illumina	Illumina	NNP
cord-002530-ao7kenbx	101	22	sequencing	sequencing	NN
cord-002530-ao7kenbx	101	23	.	.	.
cord-002530-ao7kenbx	102	1	The	the	DT
cord-002530-ao7kenbx	102	2	annotated	annotated	JJ
cord-002530-ao7kenbx	102	3	exons	exon	NNS
cord-002530-ao7kenbx	102	4	of	of	IN
cord-002530-ao7kenbx	102	5	the	the	DT
cord-002530-ao7kenbx	102	6	major	major	JJ
cord-002530-ao7kenbx	102	7	immediate	immediate	JJ
cord-002530-ao7kenbx	102	8	early	early	JJ
cord-002530-ao7kenbx	102	9	region	region	NN
cord-002530-ao7kenbx	102	10	were	be	VBD
cord-002530-ao7kenbx	102	11	clearly	clearly	RB
cord-002530-ao7kenbx	102	12	apparent	apparent	JJ
cord-002530-ao7kenbx	102	13	from	from	IN
cord-002530-ao7kenbx	102	14	the	the	DT
cord-002530-ao7kenbx	102	15	mapped	map	VBN
cord-002530-ao7kenbx	102	16	reads	read	VBZ
cord-002530-ao7kenbx	102	17	in	in	IN
cord-002530-ao7kenbx	102	18	all	all	DT
cord-002530-ao7kenbx	102	19	six	six	CD
cord-002530-ao7kenbx	102	20	samples	sample	NNS
cord-002530-ao7kenbx	102	21	and	and	CC
cord-002530-ao7kenbx	102	22	reads	read	VBZ
cord-002530-ao7kenbx	102	23	corresponding	correspond	VBG
cord-002530-ao7kenbx	102	24	to	to	IN
cord-002530-ao7kenbx	102	25	the	the	DT
cord-002530-ao7kenbx	102	26	splice	splice	NN
cord-002530-ao7kenbx	102	27	junctions	junction	NNS
cord-002530-ao7kenbx	102	28	were	be	VBD
cord-002530-ao7kenbx	102	29	consistent	consistent	JJ
cord-002530-ao7kenbx	102	30	with	with	IN
cord-002530-ao7kenbx	102	31	previous	previous	JJ
cord-002530-ao7kenbx	102	32	data	datum	NNS
cord-002530-ao7kenbx	102	33	for	for	IN
cord-002530-ao7kenbx	102	34	the	the	DT
cord-002530-ao7kenbx	102	35	region	region	NN
cord-002530-ao7kenbx	102	36	,	,	,
cord-002530-ao7kenbx	102	37	indicating	indicate	VBG
cord-002530-ao7kenbx	102	38	splicing	splice	VBG
cord-002530-ao7kenbx	102	39	between	between	IN
cord-002530-ao7kenbx	102	40	shared	shared	JJ
cord-002530-ao7kenbx	102	41	exons	exon	NNS
cord-002530-ao7kenbx	102	42	one	one	CD
cord-002530-ao7kenbx	102	43	to	to	IN
cord-002530-ao7kenbx	102	44	three	three	CD
cord-002530-ao7kenbx	102	45	and	and	CC
cord-002530-ao7kenbx	102	46	splicing	splicing	NN
cord-002530-ao7kenbx	102	47	between	between	IN
cord-002530-ao7kenbx	102	48	exon	exon	NN
cord-002530-ao7kenbx	102	49	three	three	CD
cord-002530-ao7kenbx	102	50	and	and	CC
cord-002530-ao7kenbx	102	51	four	four	CD
cord-002530-ao7kenbx	102	52	,	,	,
cord-002530-ao7kenbx	102	53	resulting	result	VBG
cord-002530-ao7kenbx	102	54	in	in	IN
cord-002530-ao7kenbx	102	55	IE1	IE1	NNP
cord-002530-ao7kenbx	102	56	transcript	transcript	NN
cord-002530-ao7kenbx	102	57	,	,	,
cord-002530-ao7kenbx	102	58	and	and	CC
cord-002530-ao7kenbx	102	59	three	three	CD
cord-002530-ao7kenbx	102	60	and	and	CC
cord-002530-ao7kenbx	102	61	five	five	CD
cord-002530-ao7kenbx	102	62	resulting	result	VBG
cord-002530-ao7kenbx	102	63	in	in	IN
cord-002530-ao7kenbx	102	64	IE2	ie2	NN
cord-002530-ao7kenbx	102	65	transcript	transcript	NN
cord-002530-ao7kenbx	102	66	(	(	-LRB-
cord-002530-ao7kenbx	102	67	S3	S3	NNP
cord-002530-ao7kenbx	102	68	Fig	Fig	NNP
cord-002530-ao7kenbx	102	69	)	)	-RRB-
cord-002530-ao7kenbx	102	70	.	.	.
cord-002530-ao7kenbx	103	1	Consistent	consistent	JJ
cord-002530-ao7kenbx	103	2	with	with	IN
cord-002530-ao7kenbx	103	3	the	the	DT
cord-002530-ao7kenbx	103	4	Northern	northern	JJ
cord-002530-ao7kenbx	103	5	blot	blot	NN
cord-002530-ao7kenbx	103	6	and	and	CC
cord-002530-ao7kenbx	103	7	qRT	qRT	NNP
cord-002530-ao7kenbx	103	8	-	-	HYPH
cord-002530-ao7kenbx	103	9	PCR	PCR	NNP
cord-002530-ao7kenbx	103	10	data	datum	NNS
cord-002530-ao7kenbx	103	11	,	,	,
cord-002530-ao7kenbx	103	12	MIE	MIE	NNP
cord-002530-ao7kenbx	103	13	transcription	transcription	NN
cord-002530-ao7kenbx	103	14	increased	increase	VBD
cord-002530-ao7kenbx	103	15	at	at	IN
cord-002530-ao7kenbx	103	16	24	24	CD
cord-002530-ao7kenbx	103	17	HPI	HPI	NNP
cord-002530-ao7kenbx	103	18	but	but	CC
cord-002530-ao7kenbx	103	19	decreased	decrease	VBD
cord-002530-ao7kenbx	103	20	at	at	IN
cord-002530-ao7kenbx	103	21	48	48	CD
cord-002530-ao7kenbx	103	22	and	and	CC
cord-002530-ao7kenbx	103	23	72	72	CD
cord-002530-ao7kenbx	103	24	HPI	HPI	NNP
cord-002530-ao7kenbx	103	25	following	follow	VBG
cord-002530-ao7kenbx	103	26	knockdown	knockdown	NN
cord-002530-ao7kenbx	103	27	of	of	IN
cord-002530-ao7kenbx	103	28	VCP	VCP	NNP
cord-002530-ao7kenbx	103	29	(	(	-LRB-
cord-002530-ao7kenbx	103	30	S4	S4	NNP
cord-002530-ao7kenbx	103	31	Fig	Fig	NNP
cord-002530-ao7kenbx	103	32	)	)	-RRB-
cord-002530-ao7kenbx	103	33	.	.	.
cord-002530-ao7kenbx	104	1	Furthermore	furthermore	RB
cord-002530-ao7kenbx	104	2	,	,	,
cord-002530-ao7kenbx	104	3	splicing	splicing	NN
cord-002530-ao7kenbx	104	4	of	of	IN
cord-002530-ao7kenbx	104	5	the	the	DT
cord-002530-ao7kenbx	104	6	MIE	MIE	NNP
cord-002530-ao7kenbx	104	7	primary	primary	JJ
cord-002530-ao7kenbx	104	8	transcript	transcript	NN
cord-002530-ao7kenbx	104	9	is	be	VBZ
cord-002530-ao7kenbx	104	10	heavily	heavily	RB
cord-002530-ao7kenbx	104	11	biased	biased	JJ
cord-002530-ao7kenbx	104	12	towards	towards	IN
cord-002530-ao7kenbx	104	13	IE1	ie1	NN
cord-002530-ao7kenbx	104	14	at	at	IN
cord-002530-ao7kenbx	104	15	24	24	CD
cord-002530-ao7kenbx	104	16	hours	hour	NNS
cord-002530-ao7kenbx	104	17	,	,	,
cord-002530-ao7kenbx	104	18	with	with	IN
cord-002530-ao7kenbx	104	19	IE2	ie2	NN
cord-002530-ao7kenbx	104	20	splicing	splicing	NN
cord-002530-ao7kenbx	104	21	increasing	increase	VBG
cord-002530-ao7kenbx	104	22	as	as	IN
cord-002530-ao7kenbx	104	23	the	the	DT
cord-002530-ao7kenbx	104	24	infection	infection	NN
cord-002530-ao7kenbx	104	25	progresses	progress	VBZ
cord-002530-ao7kenbx	104	26	(	(	-LRB-
cord-002530-ao7kenbx	104	27	S4A	S4A	NNP
cord-002530-ao7kenbx	104	28	Fig	Fig	NNP
cord-002530-ao7kenbx	104	29	)	)	-RRB-
cord-002530-ao7kenbx	104	30	.	.	.
cord-002530-ao7kenbx	105	1	To	to	TO
cord-002530-ao7kenbx	105	2	determine	determine	VB
cord-002530-ao7kenbx	105	3	whether	whether	IN
cord-002530-ao7kenbx	105	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	105	5	of	of	IN
cord-002530-ao7kenbx	105	6	VCP	VCP	NNP
cord-002530-ao7kenbx	105	7	alters	alter	VBZ
cord-002530-ao7kenbx	105	8	the	the	DT
cord-002530-ao7kenbx	105	9	balance	balance	NN
cord-002530-ao7kenbx	105	10	of	of	IN
cord-002530-ao7kenbx	105	11	splicing	splicing	NN
cord-002530-ao7kenbx	105	12	between	between	IN
cord-002530-ao7kenbx	105	13	IE1	ie1	NN
cord-002530-ao7kenbx	105	14	and	and	CC
cord-002530-ao7kenbx	105	15	IE2	ie2	NN
cord-002530-ao7kenbx	105	16	,	,	,
cord-002530-ao7kenbx	105	17	the	the	DT
cord-002530-ao7kenbx	105	18	proportion	proportion	NN
cord-002530-ao7kenbx	105	19	of	of	IN
cord-002530-ao7kenbx	105	20	total	total	JJ
cord-002530-ao7kenbx	105	21	reads	read	NNS
cord-002530-ao7kenbx	105	22	mapping	mapping	NN
cord-002530-ao7kenbx	105	23	to	to	IN
cord-002530-ao7kenbx	105	24	the	the	DT
cord-002530-ao7kenbx	105	25	five	five	CD
cord-002530-ao7kenbx	105	26	exons	exon	NNS
cord-002530-ao7kenbx	105	27	of	of	IN
cord-002530-ao7kenbx	105	28	the	the	DT
cord-002530-ao7kenbx	105	29	IE	IE	NNP
cord-002530-ao7kenbx	105	30	region	region	NN
cord-002530-ao7kenbx	105	31	were	be	VBD
cord-002530-ao7kenbx	105	32	calculated	calculate	VBN
cord-002530-ao7kenbx	105	33	(	(	-LRB-
cord-002530-ao7kenbx	105	34	S2	S2	NNP
cord-002530-ao7kenbx	105	35	Table	Table	NNP
cord-002530-ao7kenbx	105	36	)	)	-RRB-
cord-002530-ao7kenbx	105	37	.	.	.
cord-002530-ao7kenbx	106	1	Fig	Fig	NNP
cord-002530-ao7kenbx	106	2	6A	6a	CD
cord-002530-ao7kenbx	106	3	repre	repre	IN
cord-002530-ao7kenbx	106	4	sents	sents	NNP
cord-002530-ao7kenbx	107	1	the	the	DT
cord-002530-ao7kenbx	107	2	absolute	absolute	JJ
cord-002530-ao7kenbx	107	3	difference	difference	NN
cord-002530-ao7kenbx	107	4	in	in	IN
cord-002530-ao7kenbx	107	5	exon	exon	NN
cord-002530-ao7kenbx	107	6	frequencies	frequency	NNS
cord-002530-ao7kenbx	107	7	from	from	IN
cord-002530-ao7kenbx	107	8	VCP	VCP	NNP
cord-002530-ao7kenbx	107	9	knockdown	knockdown	NN
cord-002530-ao7kenbx	107	10	samples	sample	NNS
cord-002530-ao7kenbx	107	11	compared	compare	VBN
cord-002530-ao7kenbx	107	12	to	to	IN
cord-002530-ao7kenbx	107	13	negative	negative	JJ
cord-002530-ao7kenbx	107	14	control	control	NN
cord-002530-ao7kenbx	107	15	samples	sample	NNS
cord-002530-ao7kenbx	107	16	.	.	.
cord-002530-ao7kenbx	108	1	At	at	IN
cord-002530-ao7kenbx	108	2	24	24	CD
cord-002530-ao7kenbx	108	3	HPI	HPI	NNP
cord-002530-ao7kenbx	108	4	,	,	,
cord-002530-ao7kenbx	108	5	knockdown	knockdown	NN
cord-002530-ao7kenbx	108	6	of	of	IN
cord-002530-ao7kenbx	108	7	VCP	VCP	NNP
cord-002530-ao7kenbx	108	8	has	have	VBZ
cord-002530-ao7kenbx	108	9	no	no	DT
cord-002530-ao7kenbx	108	10	effect	effect	NN
cord-002530-ao7kenbx	108	11	on	on	IN
cord-002530-ao7kenbx	108	12	the	the	DT
cord-002530-ao7kenbx	108	13	relative	relative	JJ
cord-002530-ao7kenbx	108	14	proportion	proportion	NN
cord-002530-ao7kenbx	108	15	of	of	IN
cord-002530-ao7kenbx	108	16	reads	read	VBZ
cord-002530-ao7kenbx	108	17	mapping	mapping	NN
cord-002530-ao7kenbx	108	18	to	to	TO
cord-002530-ao7kenbx	108	19	exon	exon	VB
cord-002530-ao7kenbx	108	20	four	four	CD
cord-002530-ao7kenbx	108	21	and	and	CC
cord-002530-ao7kenbx	108	22	five	five	CD
cord-002530-ao7kenbx	108	23	.	.	.
cord-002530-ao7kenbx	109	1	However	however	RB
cord-002530-ao7kenbx	109	2	,	,	,
cord-002530-ao7kenbx	109	3	by	by	IN
cord-002530-ao7kenbx	109	4	48	48	CD
cord-002530-ao7kenbx	109	5	HPI	HPI	NNP
cord-002530-ao7kenbx	109	6	there	there	EX
cord-002530-ao7kenbx	109	7	is	be	VBZ
cord-002530-ao7kenbx	109	8	a	a	DT
cord-002530-ao7kenbx	109	9	clear	clear	JJ
cord-002530-ao7kenbx	109	10	increase	increase	NN
cord-002530-ao7kenbx	109	11	in	in	IN
cord-002530-ao7kenbx	109	12	the	the	DT
cord-002530-ao7kenbx	109	13	relative	relative	JJ
cord-002530-ao7kenbx	109	14	proportion	proportion	NN
cord-002530-ao7kenbx	109	15	of	of	IN
cord-002530-ao7kenbx	109	16	reads	read	VBZ
cord-002530-ao7kenbx	109	17	mapping	mapping	NN
cord-002530-ao7kenbx	109	18	to	to	TO
cord-002530-ao7kenbx	109	19	exon	exon	VB
cord-002530-ao7kenbx	109	20	four	four	CD
cord-002530-ao7kenbx	109	21	in	in	IN
cord-002530-ao7kenbx	109	22	VCP	VCP	NNP
cord-002530-ao7kenbx	109	23	knockdown	knockdown	NN
cord-002530-ao7kenbx	109	24	samples	sample	NNS
cord-002530-ao7kenbx	109	25	,	,	,
cord-002530-ao7kenbx	109	26	with	with	IN
cord-002530-ao7kenbx	109	27	a	a	DT
cord-002530-ao7kenbx	109	28	corresponding	correspond	VBG
cord-002530-ao7kenbx	109	29	decrease	decrease	NN
cord-002530-ao7kenbx	109	30	in	in	IN
cord-002530-ao7kenbx	109	31	exon	exon	NN
cord-002530-ao7kenbx	109	32	five	five	CD
cord-002530-ao7kenbx	109	33	read	read	NN
cord-002530-ao7kenbx	109	34	frequencies	frequency	NNS
cord-002530-ao7kenbx	109	35	.	.	.
cord-002530-ao7kenbx	110	1	In	in	IN
cord-002530-ao7kenbx	110	2	contrast	contrast	NN
cord-002530-ao7kenbx	110	3	knockdown	knockdown	NN
cord-002530-ao7kenbx	110	4	of	of	IN
cord-002530-ao7kenbx	110	5	VCP	VCP	NNP
cord-002530-ao7kenbx	110	6	has	have	VBZ
cord-002530-ao7kenbx	110	7	no	no	DT
cord-002530-ao7kenbx	110	8	effect	effect	NN
cord-002530-ao7kenbx	110	9	on	on	IN
cord-002530-ao7kenbx	110	10	the	the	DT
cord-002530-ao7kenbx	110	11	relative	relative	JJ
cord-002530-ao7kenbx	110	12	proportion	proportion	NN
cord-002530-ao7kenbx	110	13	of	of	IN
cord-002530-ao7kenbx	110	14	reads	read	NNS
cord-002530-ao7kenbx	110	15	mapping	mapping	NN
cord-002530-ao7kenbx	110	16	to	to	IN
cord-002530-ao7kenbx	110	17	the	the	DT
cord-002530-ao7kenbx	110	18	shared	share	VBN
cord-002530-ao7kenbx	110	19	exons	exon	NNS
cord-002530-ao7kenbx	110	20	,	,	,
cord-002530-ao7kenbx	110	21	indicating	indicate	VBG
cord-002530-ao7kenbx	110	22	reduced	reduce	VBN
cord-002530-ao7kenbx	110	23	splicing	splicing	NN
cord-002530-ao7kenbx	110	24	from	from	IN
cord-002530-ao7kenbx	110	25	exon	exon	NN
cord-002530-ao7kenbx	110	26	three	three	CD
cord-002530-ao7kenbx	110	27	to	to	TO
cord-002530-ao7kenbx	110	28	five	five	CD
cord-002530-ao7kenbx	110	29	(	(	-LRB-
cord-002530-ao7kenbx	110	30	IE2	ie2	NN
cord-002530-ao7kenbx	110	31	)	)	-RRB-
cord-002530-ao7kenbx	110	32	and	and	CC
cord-002530-ao7kenbx	110	33	a	a	DT
cord-002530-ao7kenbx	110	34	corresponding	corresponding	JJ
cord-002530-ao7kenbx	110	35	increase	increase	NN
cord-002530-ao7kenbx	110	36	in	in	IN
cord-002530-ao7kenbx	110	37	splicing	splicing	NN
cord-002530-ao7kenbx	110	38	from	from	IN
cord-002530-ao7kenbx	110	39	exon	exon	NN
cord-002530-ao7kenbx	110	40	three	three	CD
cord-002530-ao7kenbx	110	41	to	to	IN
cord-002530-ao7kenbx	110	42	four	four	CD
cord-002530-ao7kenbx	110	43	(	(	-LRB-
cord-002530-ao7kenbx	110	44	IE1	ie1	NN
cord-002530-ao7kenbx	110	45	)	)	-RRB-
cord-002530-ao7kenbx	110	46	.	.	.
cord-002530-ao7kenbx	111	1	Knockdown	knockdown	NN
cord-002530-ao7kenbx	111	2	of	of	IN
cord-002530-ao7kenbx	111	3	VCP	VCP	NNP
cord-002530-ao7kenbx	111	4	also	also	RB
cord-002530-ao7kenbx	111	5	resulted	result	VBD
cord-002530-ao7kenbx	111	6	in	in	IN
cord-002530-ao7kenbx	111	7	lower	low	JJR
cord-002530-ao7kenbx	111	8	frequencies	frequency	NNS
cord-002530-ao7kenbx	111	9	of	of	IN
cord-002530-ao7kenbx	111	10	read	read	NN
cord-002530-ao7kenbx	111	11	pairs	pair	NNS
cord-002530-ao7kenbx	111	12	spanning	span	VBG
cord-002530-ao7kenbx	111	13	exon	exon	NN
cord-002530-ao7kenbx	111	14	three	three	CD
cord-002530-ao7kenbx	111	15	to	to	TO
cord-002530-ao7kenbx	111	16	five	five	CD
cord-002530-ao7kenbx	111	17	splice	splice	NN
cord-002530-ao7kenbx	111	18	junction	junction	NN
cord-002530-ao7kenbx	111	19	(	(	-LRB-
cord-002530-ao7kenbx	111	20	IE2	IE2	NNP
cord-002530-ao7kenbx	111	21	)	)	-RRB-
cord-002530-ao7kenbx	111	22	and	and	CC
cord-002530-ao7kenbx	111	23	a	a	DT
cord-002530-ao7kenbx	111	24	corresponding	corresponding	JJ
cord-002530-ao7kenbx	111	25	increase	increase	NN
cord-002530-ao7kenbx	111	26	in	in	IN
cord-002530-ao7kenbx	111	27	read	read	NN
cord-002530-ao7kenbx	111	28	pairs	pair	NNS
cord-002530-ao7kenbx	111	29	spanning	span	VBG
cord-002530-ao7kenbx	111	30	exon	exon	NN
cord-002530-ao7kenbx	111	31	three	three	CD
cord-002530-ao7kenbx	111	32	to	to	TO
cord-002530-ao7kenbx	111	33	four	four	CD
cord-002530-ao7kenbx	111	34	splice	splice	NN
cord-002530-ao7kenbx	111	35	junction	junction	NN
cord-002530-ao7kenbx	111	36	(	(	-LRB-
cord-002530-ao7kenbx	111	37	IE1	ie1	NN
cord-002530-ao7kenbx	111	38	)	)	-RRB-
cord-002530-ao7kenbx	112	1	(	(	-LRB-
cord-002530-ao7kenbx	112	2	Fig	Fig	NNP
cord-002530-ao7kenbx	112	3	6A	6a	CD
cord-002530-ao7kenbx	112	4	and	and	CC
cord-002530-ao7kenbx	112	5	6B	6b	NN
cord-002530-ao7kenbx	112	6	,	,	,
cord-002530-ao7kenbx	112	7	S4B	S4B	NNP
cord-002530-ao7kenbx	112	8	Fig	Fig	NNP
cord-002530-ao7kenbx	112	9	and	and	CC
cord-002530-ao7kenbx	112	10	S3	S3	NNP
cord-002530-ao7kenbx	112	11	and	and	CC
cord-002530-ao7kenbx	112	12	S4	S4	NNP
cord-002530-ao7kenbx	112	13	Tables	Tables	NNP
cord-002530-ao7kenbx	112	14	)	)	-RRB-
cord-002530-ao7kenbx	112	15	.	.	.
cord-002530-ao7kenbx	113	1	These	these	DT
cord-002530-ao7kenbx	113	2	results	result	NNS
cord-002530-ao7kenbx	113	3	show	show	VBP
cord-002530-ao7kenbx	113	4	that	that	IN
cord-002530-ao7kenbx	113	5	knockdown	knockdown	NN
cord-002530-ao7kenbx	113	6	of	of	IN
cord-002530-ao7kenbx	113	7	VCP	VCP	NNP
cord-002530-ao7kenbx	113	8	alters	alter	VBZ
cord-002530-ao7kenbx	113	9	splicing	splicing	NN
cord-002530-ao7kenbx	113	10	of	of	IN
cord-002530-ao7kenbx	113	11	MIE	MIE	NNP
cord-002530-ao7kenbx	113	12	transcripts	transcript	NNS
cord-002530-ao7kenbx	113	13	resulting	result	VBG
cord-002530-ao7kenbx	113	14	in	in	IN
cord-002530-ao7kenbx	113	15	a	a	DT
cord-002530-ao7kenbx	113	16	failure	failure	NN
cord-002530-ao7kenbx	113	17	to	to	TO
cord-002530-ao7kenbx	113	18	switch	switch	VB
cord-002530-ao7kenbx	113	19	from	from	IN
cord-002530-ao7kenbx	113	20	IE1	ie1	NN
cord-002530-ao7kenbx	113	21	splicing	splice	VBG
cord-002530-ao7kenbx	113	22	to	to	IN
cord-002530-ao7kenbx	113	23	IE2	ie2	JJ
cord-002530-ao7kenbx	113	24	splicing	splicing	NN
cord-002530-ao7kenbx	113	25	.	.	.
cord-002530-ao7kenbx	114	1	To	to	TO
cord-002530-ao7kenbx	114	2	determine	determine	VB
cord-002530-ao7kenbx	114	3	whether	whether	IN
cord-002530-ao7kenbx	114	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	114	5	of	of	IN
cord-002530-ao7kenbx	114	6	VCP	VCP	NNP
cord-002530-ao7kenbx	114	7	resulted	result	VBD
cord-002530-ao7kenbx	114	8	in	in	IN
cord-002530-ao7kenbx	114	9	more	more	RBR
cord-002530-ao7kenbx	114	10	generalized	generalized	JJ
cord-002530-ao7kenbx	114	11	effects	effect	NNS
cord-002530-ao7kenbx	114	12	on	on	IN
cord-002530-ao7kenbx	114	13	virus	virus	NN
cord-002530-ao7kenbx	114	14	transcript	transcript	NN
cord-002530-ao7kenbx	114	15	splicing	splicing	NN
cord-002530-ao7kenbx	114	16	,	,	,
cord-002530-ao7kenbx	114	17	we	-PRON-	PRP
cord-002530-ao7kenbx	114	18	analysed	analyse	VBD
cord-002530-ao7kenbx	114	19	read	read	VBD
cord-002530-ao7kenbx	114	20	counts	count	VBZ
cord-002530-ao7kenbx	114	21	for	for	IN
cord-002530-ao7kenbx	114	22	other	other	JJ
cord-002530-ao7kenbx	114	23	well	well	RB
cord-002530-ao7kenbx	114	24	-	-	HYPH
cord-002530-ao7kenbx	114	25	characterized	characterize	VBN
cord-002530-ao7kenbx	114	26	HCMV	HCMV	NNP
cord-002530-ao7kenbx	114	27	spliced	splice	VBN
cord-002530-ao7kenbx	114	28	transcripts	transcript	NNS
cord-002530-ao7kenbx	114	29	(	(	-LRB-
cord-002530-ao7kenbx	114	30	S5	S5	NNP
cord-002530-ao7kenbx	114	31	Fig	Fig	NNP
cord-002530-ao7kenbx	114	32	)	)	-RRB-
cord-002530-ao7kenbx	114	33	.	.	.
cord-002530-ao7kenbx	115	1	Based	base	VBN
cord-002530-ao7kenbx	115	2	on	on	IN
cord-002530-ao7kenbx	115	3	exon	exon	NN
cord-002530-ao7kenbx	115	4	counts	count	NNS
cord-002530-ao7kenbx	115	5	,	,	,
cord-002530-ao7kenbx	115	6	only	only	RB
cord-002530-ao7kenbx	115	7	UL37	UL37	NNP
cord-002530-ao7kenbx	115	8	showed	show	VBD
cord-002530-ao7kenbx	115	9	a	a	DT
cord-002530-ao7kenbx	115	10	similar	similar	JJ
cord-002530-ao7kenbx	115	11	pattern	pattern	NN
cord-002530-ao7kenbx	115	12	to	to	IN
cord-002530-ao7kenbx	115	13	MIE	MIE	NNP
cord-002530-ao7kenbx	115	14	transcripts	transcript	NNS
cord-002530-ao7kenbx	115	15	in	in	IN
cord-002530-ao7kenbx	115	16	response	response	NN
cord-002530-ao7kenbx	115	17	to	to	IN
cord-002530-ao7kenbx	115	18	VCP	VCP	NNP
cord-002530-ao7kenbx	115	19	knockdown	knockdown	NN
cord-002530-ao7kenbx	115	20	where	where	WRB
cord-002530-ao7kenbx	115	21	absolute	absolute	JJ
cord-002530-ao7kenbx	115	22	exon	exon	NN
cord-002530-ao7kenbx	115	23	frequencies	frequency	NNS
cord-002530-ao7kenbx	115	24	for	for	IN
cord-002530-ao7kenbx	115	25	UL37	UL37	NNP
cord-002530-ao7kenbx	115	26	exon	exon	NN
cord-002530-ao7kenbx	115	27	1	1	CD
cord-002530-ao7kenbx	115	28	increased	increase	VBD
cord-002530-ao7kenbx	115	29	with	with	IN
cord-002530-ao7kenbx	115	30	a	a	DT
cord-002530-ao7kenbx	115	31	corresponding	corresponding	JJ
cord-002530-ao7kenbx	115	32	decrease	decrease	NN
cord-002530-ao7kenbx	115	33	in	in	IN
cord-002530-ao7kenbx	115	34	exon	exon	NN
cord-002530-ao7kenbx	115	35	3	3	CD
cord-002530-ao7kenbx	115	36	read	read	NN
cord-002530-ao7kenbx	115	37	frequencies	frequency	NNS
cord-002530-ao7kenbx	115	38	.	.	.
cord-002530-ao7kenbx	116	1	However	however	RB
cord-002530-ao7kenbx	116	2	,	,	,
cord-002530-ao7kenbx	116	3	unlike	unlike	IN
cord-002530-ao7kenbx	116	4	the	the	DT
cord-002530-ao7kenbx	116	5	MIE	MIE	NNP
cord-002530-ao7kenbx	116	6	transcripts	transcript	NNS
cord-002530-ao7kenbx	116	7	,	,	,
cord-002530-ao7kenbx	116	8	analysis	analysis	NN
cord-002530-ao7kenbx	116	9	of	of	IN
cord-002530-ao7kenbx	116	10	paired	pair	VBN
cord-002530-ao7kenbx	116	11	-	-	HYPH
cord-002530-ao7kenbx	116	12	end	end	NN
cord-002530-ao7kenbx	116	13	reads	read	NNS
cord-002530-ao7kenbx	116	14	did	do	VBD
cord-002530-ao7kenbx	116	15	not	not	RB
cord-002530-ao7kenbx	116	16	support	support	VB
cord-002530-ao7kenbx	116	17	substantial	substantial	JJ
cord-002530-ao7kenbx	116	18	splicing	splicing	NN
cord-002530-ao7kenbx	116	19	between	between	IN
cord-002530-ao7kenbx	116	20	UL37	UL37	NNP
cord-002530-ao7kenbx	116	21	exon	exon	NN
cord-002530-ao7kenbx	116	22	1	1	CD
cord-002530-ao7kenbx	116	23	to	to	IN
cord-002530-ao7kenbx	116	24	exons	exon	NNS
cord-002530-ao7kenbx	116	25	2	2	CD
cord-002530-ao7kenbx	116	26	and	and	CC
cord-002530-ao7kenbx	116	27	3	3	CD
cord-002530-ao7kenbx	116	28	(	(	-LRB-
cord-002530-ao7kenbx	116	29	S3	S3	NNP
cord-002530-ao7kenbx	116	30	Fig	Fig	NNP
cord-002530-ao7kenbx	116	31	)	)	-RRB-
cord-002530-ao7kenbx	116	32	.	.	.
cord-002530-ao7kenbx	117	1	Instead	instead	RB
cord-002530-ao7kenbx	117	2	,	,	,
cord-002530-ao7kenbx	117	3	exon	exon	NN
cord-002530-ao7kenbx	117	4	1	1	CD
cord-002530-ao7kenbx	117	5	and	and	CC
cord-002530-ao7kenbx	117	6	exons	exon	NNS
cord-002530-ao7kenbx	117	7	2	2	CD
cord-002530-ao7kenbx	117	8	and	and	CC
cord-002530-ao7kenbx	117	9	3	3	CD
cord-002530-ao7kenbx	117	10	of	of	IN
cord-002530-ao7kenbx	117	11	UL37	UL37	NNP
cord-002530-ao7kenbx	117	12	are	be	VBP
cord-002530-ao7kenbx	117	13	likely	likely	JJ
cord-002530-ao7kenbx	117	14	to	to	TO
cord-002530-ao7kenbx	117	15	be	be	VB
cord-002530-ao7kenbx	117	16	predominantly	predominantly	RB
cord-002530-ao7kenbx	117	17	independent	independent	JJ
cord-002530-ao7kenbx	117	18	transcriptional	transcriptional	JJ
cord-002530-ao7kenbx	117	19	units	unit	NNS
cord-002530-ao7kenbx	117	20	with	with	IN
cord-002530-ao7kenbx	117	21	differing	differ	VBG
cord-002530-ao7kenbx	117	22	kinetics	kinetic	NNS
cord-002530-ao7kenbx	117	23	,	,	,
cord-002530-ao7kenbx	117	24	with	with	IN
cord-002530-ao7kenbx	117	25	exon	exon	NN
cord-002530-ao7kenbx	117	26	2	2	CD
cord-002530-ao7kenbx	117	27	and	and	CC
cord-002530-ao7kenbx	117	28	3	3	CD
cord-002530-ao7kenbx	117	29	requiring	require	VBG
cord-002530-ao7kenbx	117	30	IE2	ie2	JJ
cord-002530-ao7kenbx	117	31	expression	expression	NN
cord-002530-ao7kenbx	117	32	for	for	IN
cord-002530-ao7kenbx	117	33	transactivation	transactivation	NN
cord-002530-ao7kenbx	117	34	.	.	.
cord-002530-ao7kenbx	118	1	To	to	TO
cord-002530-ao7kenbx	118	2	determine	determine	VB
cord-002530-ao7kenbx	118	3	the	the	DT
cord-002530-ao7kenbx	118	4	effect	effect	NN
cord-002530-ao7kenbx	118	5	of	of	IN
cord-002530-ao7kenbx	118	6	VCP	VCP	NNP
cord-002530-ao7kenbx	118	7	knockdown	knockdown	NN
cord-002530-ao7kenbx	118	8	on	on	IN
cord-002530-ao7kenbx	118	9	global	global	JJ
cord-002530-ao7kenbx	118	10	viral	viral	JJ
cord-002530-ao7kenbx	118	11	gene	gene	NN
cord-002530-ao7kenbx	118	12	expression	expression	NN
cord-002530-ao7kenbx	118	13	,	,	,
cord-002530-ao7kenbx	118	14	read	read	VB
cord-002530-ao7kenbx	118	15	counts	count	NNS
cord-002530-ao7kenbx	118	16	were	be	VBD
cord-002530-ao7kenbx	118	17	mapped	map	VBN
cord-002530-ao7kenbx	118	18	to	to	IN
cord-002530-ao7kenbx	118	19	the	the	DT
cord-002530-ao7kenbx	118	20	entire	entire	JJ
cord-002530-ao7kenbx	118	21	viral	viral	JJ
cord-002530-ao7kenbx	118	22	genome	genome	NN
cord-002530-ao7kenbx	118	23	.	.	.
cord-002530-ao7kenbx	119	1	As	as	IN
cord-002530-ao7kenbx	119	2	shown	show	VBN
cord-002530-ao7kenbx	119	3	in	in	IN
cord-002530-ao7kenbx	119	4	Supplemental	Supplemental	NNP
cord-002530-ao7kenbx	119	5	Fig	Fig	NNP
cord-002530-ao7kenbx	119	6	6	6	CD
cord-002530-ao7kenbx	119	7	total	total	JJ
cord-002530-ao7kenbx	119	8	read	read	NN
cord-002530-ao7kenbx	119	9	counts	count	VBZ
cord-002530-ao7kenbx	119	10	mapping	mapping	NN
cord-002530-ao7kenbx	119	11	to	to	IN
cord-002530-ao7kenbx	119	12	the	the	DT
cord-002530-ao7kenbx	119	13	viral	viral	JJ
cord-002530-ao7kenbx	119	14	genome	genome	NN
cord-002530-ao7kenbx	119	15	were	be	VBD
cord-002530-ao7kenbx	119	16	relatively	relatively	RB
cord-002530-ao7kenbx	119	17	similar	similar	JJ
cord-002530-ao7kenbx	119	18	at	at	IN
cord-002530-ao7kenbx	119	19	24	24	CD
cord-002530-ao7kenbx	119	20	HPI	HPI	NNP
cord-002530-ao7kenbx	119	21	.	.	.
cord-002530-ao7kenbx	120	1	However	however	RB
cord-002530-ao7kenbx	120	2	,	,	,
cord-002530-ao7kenbx	120	3	while	while	IN
cord-002530-ao7kenbx	120	4	viral	viral	JJ
cord-002530-ao7kenbx	120	5	gene	gene	NN
cord-002530-ao7kenbx	120	6	expression	expression	NN
cord-002530-ao7kenbx	120	7	increased	increase	VBD
cord-002530-ao7kenbx	120	8	in	in	IN
cord-002530-ao7kenbx	120	9	control	control	NN
cord-002530-ao7kenbx	120	10	cells	cell	NNS
cord-002530-ao7kenbx	120	11	by	by	IN
cord-002530-ao7kenbx	120	12	approximately	approximately	RB
cord-002530-ao7kenbx	120	13	6.5	6.5	CD
cord-002530-ao7kenbx	120	14	fold	fold	NN
cord-002530-ao7kenbx	120	15	between	between	IN
cord-002530-ao7kenbx	120	16	24	24	CD
cord-002530-ao7kenbx	120	17	and	and	CC
cord-002530-ao7kenbx	120	18	72	72	CD
cord-002530-ao7kenbx	120	19	HPI	HPI	NNP
cord-002530-ao7kenbx	120	20	,	,	,
cord-002530-ao7kenbx	120	21	expression	expression	NN
cord-002530-ao7kenbx	120	22	in	in	IN
cord-002530-ao7kenbx	120	23	VCP	VCP	NNP
cord-002530-ao7kenbx	120	24	knockdown	knockdown	NN
cord-002530-ao7kenbx	120	25	cells	cell	NNS
cord-002530-ao7kenbx	120	26	only	only	RB
cord-002530-ao7kenbx	120	27	increased	increase	VBD
cord-002530-ao7kenbx	120	28	by	by	IN
cord-002530-ao7kenbx	120	29	3-fold	3-fold	CD
cord-002530-ao7kenbx	120	30	,	,	,
cord-002530-ao7kenbx	120	31	indicating	indicate	VBG
cord-002530-ao7kenbx	120	32	a	a	DT
cord-002530-ao7kenbx	120	33	general	general	JJ
cord-002530-ao7kenbx	120	34	reduction	reduction	NN
cord-002530-ao7kenbx	120	35	in	in	IN
cord-002530-ao7kenbx	120	36	viral	viral	JJ
cord-002530-ao7kenbx	120	37	gene	gene	NN
cord-002530-ao7kenbx	120	38	expression	expression	NN
cord-002530-ao7kenbx	120	39	following	follow	VBG
cord-002530-ao7kenbx	120	40	VCP	VCP	NNP
cord-002530-ao7kenbx	120	41	knockdown	knockdown	NN
cord-002530-ao7kenbx	120	42	.	.	.
cord-002530-ao7kenbx	121	1	This	this	DT
cord-002530-ao7kenbx	121	2	is	be	VBZ
cord-002530-ao7kenbx	121	3	unsurprising	unsurprising	JJ
cord-002530-ao7kenbx	121	4	given	give	VBN
cord-002530-ao7kenbx	121	5	the	the	DT
cord-002530-ao7kenbx	121	6	vital	vital	JJ
cord-002530-ao7kenbx	121	7	role	role	NN
cord-002530-ao7kenbx	121	8	IE2	ie2	NN
cord-002530-ao7kenbx	121	9	protein	protein	NN
cord-002530-ao7kenbx	121	10	plays	play	VBZ
cord-002530-ao7kenbx	121	11	in	in	IN
cord-002530-ao7kenbx	121	12	transactivation	transactivation	NN
cord-002530-ao7kenbx	121	13	of	of	IN
cord-002530-ao7kenbx	121	14	viral	viral	JJ
cord-002530-ao7kenbx	121	15	gene	gene	NN
cord-002530-ao7kenbx	121	16	expression	expression	NN
cord-002530-ao7kenbx	121	17	.	.	.
cord-002530-ao7kenbx	122	1	To	to	TO
cord-002530-ao7kenbx	122	2	determine	determine	VB
cord-002530-ao7kenbx	122	3	whether	whether	IN
cord-002530-ao7kenbx	122	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	122	5	of	of	IN
cord-002530-ao7kenbx	122	6	VCP	VCP	NNP
cord-002530-ao7kenbx	122	7	results	result	NNS
cord-002530-ao7kenbx	122	8	in	in	IN
cord-002530-ao7kenbx	122	9	a	a	DT
cord-002530-ao7kenbx	122	10	similar	similar	JJ
cord-002530-ao7kenbx	122	11	effect	effect	NN
cord-002530-ao7kenbx	122	12	on	on	IN
cord-002530-ao7kenbx	122	13	all	all	DT
cord-002530-ao7kenbx	122	14	viral	viral	JJ
cord-002530-ao7kenbx	122	15	genes	gene	NNS
cord-002530-ao7kenbx	122	16	or	or	CC
cord-002530-ao7kenbx	122	17	differential	differential	JJ
cord-002530-ao7kenbx	122	18	effects	effect	NNS
cord-002530-ao7kenbx	122	19	,	,	,
cord-002530-ao7kenbx	122	20	total	total	JJ
cord-002530-ao7kenbx	122	21	reads	read	NNS
cord-002530-ao7kenbx	122	22	were	be	VBD
cord-002530-ao7kenbx	122	23	mapped	map	VBN
cord-002530-ao7kenbx	122	24	to	to	IN
cord-002530-ao7kenbx	122	25	individual	individual	JJ
cord-002530-ao7kenbx	122	26	viral	viral	JJ
cord-002530-ao7kenbx	122	27	open	open	JJ
cord-002530-ao7kenbx	122	28	reading	reading	NN
cord-002530-ao7kenbx	122	29	frames	frame	NNS
cord-002530-ao7kenbx	122	30	and	and	CC
cord-002530-ao7kenbx	122	31	viral	viral	JJ
cord-002530-ao7kenbx	122	32	gene	gene	NN
cord-002530-ao7kenbx	122	33	expression	expression	NN
cord-002530-ao7kenbx	122	34	compared	compare	VBN
cord-002530-ao7kenbx	122	35	between	between	IN
cord-002530-ao7kenbx	122	36	control	control	NN
cord-002530-ao7kenbx	122	37	cells	cell	NNS
cord-002530-ao7kenbx	122	38	and	and	CC
cord-002530-ao7kenbx	122	39	VCP	VCP	NNP
cord-002530-ao7kenbx	122	40	knockdown	knockdown	NN
cord-002530-ao7kenbx	122	41	cells	cell	NNS
cord-002530-ao7kenbx	122	42	(	(	-LRB-
cord-002530-ao7kenbx	122	43	Fig	Fig	NNP
cord-002530-ao7kenbx	122	44	7	7	CD
cord-002530-ao7kenbx	122	45	and	and	CC
cord-002530-ao7kenbx	122	46	S5	S5	NNP
cord-002530-ao7kenbx	122	47	 	 	_SP
cord-002530-ao7kenbx	122	48	Table	Table	NNP
cord-002530-ao7kenbx	122	49	)	)	-RRB-
cord-002530-ao7kenbx	122	50	.	.	.
cord-002530-ao7kenbx	123	1	At	at	IN
cord-002530-ao7kenbx	123	2	24	24	CD
cord-002530-ao7kenbx	123	3	HPI	HPI	NNP
cord-002530-ao7kenbx	123	4	moderate	moderate	JJ
cord-002530-ao7kenbx	123	5	reductions	reduction	NNS
cord-002530-ao7kenbx	123	6	in	in	IN
cord-002530-ao7kenbx	123	7	viral	viral	JJ
cord-002530-ao7kenbx	123	8	gene	gene	NN
cord-002530-ao7kenbx	123	9	expression	expression	NN
cord-002530-ao7kenbx	123	10	can	can	MD
cord-002530-ao7kenbx	123	11	be	be	VB
cord-002530-ao7kenbx	123	12	observed	observe	VBN
cord-002530-ao7kenbx	123	13	,	,	,
cord-002530-ao7kenbx	123	14	with	with	IN
cord-002530-ao7kenbx	123	15	a	a	DT
cord-002530-ao7kenbx	123	16	subset	subset	NN
cord-002530-ao7kenbx	123	17	of	of	IN
cord-002530-ao7kenbx	123	18	transcripts	transcript	NNS
cord-002530-ao7kenbx	123	19	expressed	express	VBN
cord-002530-ao7kenbx	123	20	at	at	IN
cord-002530-ao7kenbx	123	21	relatively	relatively	RB
cord-002530-ao7kenbx	123	22	higher	high	JJR
cord-002530-ao7kenbx	123	23	levels	level	NNS
cord-002530-ao7kenbx	123	24	following	follow	VBG
cord-002530-ao7kenbx	123	25	VCP	VCP	NNP
cord-002530-ao7kenbx	123	26	knockdown	knockdown	NN
cord-002530-ao7kenbx	123	27	.	.	.
cord-002530-ao7kenbx	124	1	In	in	IN
cord-002530-ao7kenbx	124	2	particular	particular	JJ
cord-002530-ao7kenbx	124	3	,	,	,
cord-002530-ao7kenbx	124	4	The	the	DT
cord-002530-ao7kenbx	124	5	proportion	proportion	NN
cord-002530-ao7kenbx	124	6	of	of	IN
cord-002530-ao7kenbx	124	7	total	total	JJ
cord-002530-ao7kenbx	124	8	reads	read	NNS
cord-002530-ao7kenbx	124	9	mapping	mapping	NN
cord-002530-ao7kenbx	124	10	to	to	IN
cord-002530-ao7kenbx	124	11	each	each	DT
cord-002530-ao7kenbx	124	12	of	of	IN
cord-002530-ao7kenbx	124	13	the	the	DT
cord-002530-ao7kenbx	124	14	five	five	CD
cord-002530-ao7kenbx	124	15	exons	exon	NNS
cord-002530-ao7kenbx	124	16	was	be	VBD
cord-002530-ao7kenbx	124	17	calculated	calculate	VBN
cord-002530-ao7kenbx	124	18	,	,	,
cord-002530-ao7kenbx	124	19	with	with	IN
cord-002530-ao7kenbx	124	20	the	the	DT
cord-002530-ao7kenbx	124	21	absolute	absolute	JJ
cord-002530-ao7kenbx	124	22	difference	difference	NN
cord-002530-ao7kenbx	124	23	in	in	IN
cord-002530-ao7kenbx	124	24	these	these	DT
cord-002530-ao7kenbx	124	25	values	value	NNS
cord-002530-ao7kenbx	124	26	between	between	IN
cord-002530-ao7kenbx	124	27	VCP	VCP	NNP
cord-002530-ao7kenbx	124	28	knockdown	knockdown	NN
cord-002530-ao7kenbx	124	29	and	and	CC
cord-002530-ao7kenbx	124	30	corresponding	corresponding	JJ
cord-002530-ao7kenbx	124	31	negative	negative	JJ
cord-002530-ao7kenbx	124	32	control	control	NN
cord-002530-ao7kenbx	124	33	shown	show	VBN
cord-002530-ao7kenbx	124	34	(	(	-LRB-
cord-002530-ao7kenbx	124	35	numbers	number	NNS
cord-002530-ao7kenbx	124	36	within	within	IN
cord-002530-ao7kenbx	124	37	exons	exon	NNS
cord-002530-ao7kenbx	124	38	)	)	-RRB-
cord-002530-ao7kenbx	124	39	.	.	.
cord-002530-ao7kenbx	125	1	Knockdown	knockdown	NN
cord-002530-ao7kenbx	125	2	of	of	IN
cord-002530-ao7kenbx	125	3	VCP	VCP	NNP
cord-002530-ao7kenbx	125	4	has	have	VBZ
cord-002530-ao7kenbx	125	5	no	no	DT
cord-002530-ao7kenbx	125	6	effect	effect	NN
cord-002530-ao7kenbx	125	7	on	on	IN
cord-002530-ao7kenbx	125	8	the	the	DT
cord-002530-ao7kenbx	125	9	proportion	proportion	NN
cord-002530-ao7kenbx	125	10	of	of	IN
cord-002530-ao7kenbx	125	11	reads	read	NNS
cord-002530-ao7kenbx	125	12	originating	originate	VBG
cord-002530-ao7kenbx	125	13	from	from	IN
cord-002530-ao7kenbx	125	14	exons	exon	NNS
cord-002530-ao7kenbx	125	15	1	1	CD
cord-002530-ao7kenbx	125	16	,	,	,
cord-002530-ao7kenbx	125	17	2	2	CD
cord-002530-ao7kenbx	125	18	or	or	CC
cord-002530-ao7kenbx	125	19	3	3	CD
cord-002530-ao7kenbx	125	20	,	,	,
cord-002530-ao7kenbx	125	21	but	but	CC
cord-002530-ao7kenbx	125	22	is	be	VBZ
cord-002530-ao7kenbx	125	23	associated	associate	VBN
cord-002530-ao7kenbx	125	24	with	with	IN
cord-002530-ao7kenbx	125	25	a	a	DT
cord-002530-ao7kenbx	125	26	greater	great	JJR
cord-002530-ao7kenbx	125	27	proportion	proportion	NN
cord-002530-ao7kenbx	125	28	of	of	IN
cord-002530-ao7kenbx	125	29	reads	read	NNS
cord-002530-ao7kenbx	125	30	derived	derive	VBN
cord-002530-ao7kenbx	125	31	from	from	IN
cord-002530-ao7kenbx	125	32	exon	exon	NN
cord-002530-ao7kenbx	125	33	4	4	CD
cord-002530-ao7kenbx	125	34	(	(	-LRB-
cord-002530-ao7kenbx	125	35	IE1	ie1	NN
cord-002530-ao7kenbx	125	36	)	)	-RRB-
cord-002530-ao7kenbx	125	37	and	and	CC
cord-002530-ao7kenbx	125	38	decreased	decrease	VBD
cord-002530-ao7kenbx	125	39	numbers	number	NNS
cord-002530-ao7kenbx	125	40	from	from	IN
cord-002530-ao7kenbx	125	41	exon	exon	NN
cord-002530-ao7kenbx	125	42	5	5	CD
cord-002530-ao7kenbx	125	43	(	(	-LRB-
cord-002530-ao7kenbx	125	44	IE2	IE2	NNP
cord-002530-ao7kenbx	125	45	)	)	-RRB-
cord-002530-ao7kenbx	125	46	.	.	.
cord-002530-ao7kenbx	126	1	(	(	-LRB-
cord-002530-ao7kenbx	126	2	B	b	NN
cord-002530-ao7kenbx	126	3	)	)	-RRB-
cord-002530-ao7kenbx	126	4	Log	log	VB
cord-002530-ao7kenbx	126	5	2	2	CD
cord-002530-ao7kenbx	126	6	ratios	ratio	NNS
cord-002530-ao7kenbx	126	7	of	of	IN
cord-002530-ao7kenbx	126	8	the	the	DT
cord-002530-ao7kenbx	126	9	proportions	proportion	NNS
cord-002530-ao7kenbx	126	10	of	of	IN
cord-002530-ao7kenbx	126	11	reads	read	NNS
cord-002530-ao7kenbx	126	12	mapping	mapping	NN
cord-002530-ao7kenbx	126	13	to	to	TO
cord-002530-ao7kenbx	126	14	exon	exon	VB
cord-002530-ao7kenbx	126	15	3	3	CD
cord-002530-ao7kenbx	126	16	whose	whose	WP$
cord-002530-ao7kenbx	126	17	matching	matching	JJ
cord-002530-ao7kenbx	126	18	pair	pair	NN
cord-002530-ao7kenbx	126	19	maps	map	NNS
cord-002530-ao7kenbx	126	20	to	to	IN
cord-002530-ao7kenbx	126	21	either	either	DT
cord-002530-ao7kenbx	126	22	exons	exon	NNS
cord-002530-ao7kenbx	126	23	2	2	CD
cord-002530-ao7kenbx	126	24	,	,	,
cord-002530-ao7kenbx	126	25	4	4	CD
cord-002530-ao7kenbx	126	26	or	or	CC
cord-002530-ao7kenbx	126	27	5	5	CD
cord-002530-ao7kenbx	126	28	are	be	VBP
cord-002530-ao7kenbx	126	29	shown	show	VBN
cord-002530-ao7kenbx	126	30	.	.	.
cord-002530-ao7kenbx	127	1	The	the	DT
cord-002530-ao7kenbx	127	2	proportion	proportion	NN
cord-002530-ao7kenbx	127	3	of	of	IN
cord-002530-ao7kenbx	127	4	read	read	NN
cord-002530-ao7kenbx	127	5	pairs	pair	NNS
cord-002530-ao7kenbx	127	6	spanning	span	VBG
cord-002530-ao7kenbx	127	7	the	the	DT
cord-002530-ao7kenbx	127	8	shared	share	VBN
cord-002530-ao7kenbx	127	9	splice	splice	NN
cord-002530-ao7kenbx	127	10	junction	junction	NN
cord-002530-ao7kenbx	127	11	between	between	IN
cord-002530-ao7kenbx	127	12	exon	exon	NN
cord-002530-ao7kenbx	127	13	two	two	CD
cord-002530-ao7kenbx	127	14	and	and	CC
cord-002530-ao7kenbx	127	15	three	three	CD
cord-002530-ao7kenbx	127	16	is	be	VBZ
cord-002530-ao7kenbx	127	17	unaffected	unaffected	JJ
cord-002530-ao7kenbx	127	18	by	by	IN
cord-002530-ao7kenbx	127	19	VCP	VCP	NNP
cord-002530-ao7kenbx	127	20	knockdown	knockdown	NN
cord-002530-ao7kenbx	127	21	,	,	,
cord-002530-ao7kenbx	127	22	whereas	whereas	IN
cord-002530-ao7kenbx	127	23	exon	exon	NNP
cord-002530-ao7kenbx	127	24	3	3	CD
cord-002530-ao7kenbx	127	25	to	to	IN
cord-002530-ao7kenbx	127	26	4	4	CD
cord-002530-ao7kenbx	127	27	frequency	frequency	NN
cord-002530-ao7kenbx	127	28	increases	increase	NNS
cord-002530-ao7kenbx	127	29	and	and	CC
cord-002530-ao7kenbx	127	30	3	3	CD
cord-002530-ao7kenbx	127	31	to	to	TO
cord-002530-ao7kenbx	127	32	5	5	CD
cord-002530-ao7kenbx	127	33	decreases	decrease	NNS
cord-002530-ao7kenbx	127	34	.	.	.
cord-002530-ao7kenbx	128	1	https://doi.org/10.1371/journal.ppat.1006329.g006	https://doi.org/10.1371/journal.ppat.1006329.g006	JJ
cord-002530-ao7kenbx	128	2	expression	expression	NN
cord-002530-ao7kenbx	128	3	levels	level	NNS
cord-002530-ao7kenbx	128	4	of	of	IN
cord-002530-ao7kenbx	128	5	UL36	UL36	NNP
cord-002530-ao7kenbx	128	6	and	and	CC
cord-002530-ao7kenbx	128	7	UL37	UL37	NNP
cord-002530-ao7kenbx	128	8	,	,	,
cord-002530-ao7kenbx	128	9	UL112/113	ul112/113	JJ
cord-002530-ao7kenbx	128	10	and	and	CC
cord-002530-ao7kenbx	128	11	the	the	DT
cord-002530-ao7kenbx	128	12	MIE	MIE	NNP
cord-002530-ao7kenbx	128	13	transcripts	transcript	NNS
cord-002530-ao7kenbx	129	1	UL122	UL122	NNP
cord-002530-ao7kenbx	129	2	(	(	-LRB-
cord-002530-ao7kenbx	129	3	IE2	IE2	NNP
cord-002530-ao7kenbx	129	4	)	)	-RRB-
cord-002530-ao7kenbx	129	5	and	and	CC
cord-002530-ao7kenbx	129	6	UL123	UL123	NNP
cord-002530-ao7kenbx	129	7	(	(	-LRB-
cord-002530-ao7kenbx	129	8	IE1	ie1	NN
cord-002530-ao7kenbx	129	9	)	)	-RRB-
cord-002530-ao7kenbx	129	10	were	be	VBD
cord-002530-ao7kenbx	129	11	relatively	relatively	RB
cord-002530-ao7kenbx	129	12	higher	high	JJR
cord-002530-ao7kenbx	129	13	at	at	IN
cord-002530-ao7kenbx	129	14	24HPI	24hpi	CD
cord-002530-ao7kenbx	129	15	in	in	IN
cord-002530-ao7kenbx	129	16	VCP	VCP	NNP
cord-002530-ao7kenbx	129	17	knockdown	knockdown	NN
cord-002530-ao7kenbx	129	18	cells	cell	NNS
cord-002530-ao7kenbx	129	19	compared	compare	VBN
cord-002530-ao7kenbx	129	20	to	to	IN
cord-002530-ao7kenbx	129	21	control	control	NN
cord-002530-ao7kenbx	129	22	cells	cell	NNS
cord-002530-ao7kenbx	129	23	.	.	.
cord-002530-ao7kenbx	130	1	However	however	RB
cord-002530-ao7kenbx	130	2	,	,	,
cord-002530-ao7kenbx	130	3	at	at	IN
cord-002530-ao7kenbx	130	4	48	48	CD
cord-002530-ao7kenbx	130	5	and	and	CC
cord-002530-ao7kenbx	130	6	72	72	CD
cord-002530-ao7kenbx	130	7	HPI	HPI	NNP
cord-002530-ao7kenbx	130	8	there	there	EX
cord-002530-ao7kenbx	130	9	is	be	VBZ
cord-002530-ao7kenbx	130	10	more	more	RBR
cord-002530-ao7kenbx	130	11	profound	profound	JJ
cord-002530-ao7kenbx	130	12	global	global	JJ
cord-002530-ao7kenbx	130	13	suppression	suppression	NN
cord-002530-ao7kenbx	130	14	of	of	IN
cord-002530-ao7kenbx	130	15	virus	virus	NN
cord-002530-ao7kenbx	130	16	gene	gene	NN
cord-002530-ao7kenbx	130	17	expression	expression	NN
cord-002530-ao7kenbx	130	18	in	in	IN
cord-002530-ao7kenbx	130	19	VCP	VCP	NNP
cord-002530-ao7kenbx	130	20	knockdown	knockdown	NN
cord-002530-ao7kenbx	130	21	cells	cell	NNS
cord-002530-ao7kenbx	130	22	.	.	.
cord-002530-ao7kenbx	131	1	This	this	DT
cord-002530-ao7kenbx	131	2	is	be	VBZ
cord-002530-ao7kenbx	131	3	particularly	particularly	RB
cord-002530-ao7kenbx	131	4	apparent	apparent	JJ
cord-002530-ao7kenbx	131	5	for	for	IN
cord-002530-ao7kenbx	131	6	the	the	DT
cord-002530-ao7kenbx	131	7	non	non	JJ
cord-002530-ao7kenbx	131	8	-	-	JJ
cord-002530-ao7kenbx	131	9	coding	coding	JJ
cord-002530-ao7kenbx	131	10	genes	gene	NNS
cord-002530-ao7kenbx	131	11	RNA	RNA	NNP
cord-002530-ao7kenbx	131	12	4.9	4.9	CD
cord-002530-ao7kenbx	131	13	and	and	CC
cord-002530-ao7kenbx	131	14	5.0	5.0	CD
cord-002530-ao7kenbx	131	15	and	and	CC
cord-002530-ao7kenbx	131	16	other	other	JJ
cord-002530-ao7kenbx	131	17	genes	gene	NNS
cord-002530-ao7kenbx	131	18	that	that	WDT
cord-002530-ao7kenbx	131	19	are	be	VBP
cord-002530-ao7kenbx	131	20	highly	highly	RB
cord-002530-ao7kenbx	131	21	up	up	RB
cord-002530-ao7kenbx	131	22	regulated	regulate	VBN
cord-002530-ao7kenbx	131	23	at	at	IN
cord-002530-ao7kenbx	131	24	later	later	JJ
cord-002530-ao7kenbx	131	25	stages	stage	NNS
cord-002530-ao7kenbx	131	26	of	of	IN
cord-002530-ao7kenbx	131	27	infection	infection	NN
cord-002530-ao7kenbx	131	28	,	,	,
cord-002530-ao7kenbx	131	29	including	include	VBG
cord-002530-ao7kenbx	131	30	UL85	UL85	NNP
cord-002530-ao7kenbx	131	31	,	,	,
cord-002530-ao7kenbx	131	32	UL86	UL86	NNP
cord-002530-ao7kenbx	131	33	,	,	,
cord-002530-ao7kenbx	131	34	UL100	UL100	NNP
cord-002530-ao7kenbx	131	35	and	and	CC
cord-002530-ao7kenbx	131	36	UL102	UL102	NNP
cord-002530-ao7kenbx	131	37	.	.	.
cord-002530-ao7kenbx	132	1	Despite	despite	IN
cord-002530-ao7kenbx	132	2	the	the	DT
cord-002530-ao7kenbx	132	3	loss	loss	NN
cord-002530-ao7kenbx	132	4	of	of	IN
cord-002530-ao7kenbx	132	5	IE2	ie2	JJ
cord-002530-ao7kenbx	132	6	expression	expression	NN
cord-002530-ao7kenbx	132	7	,	,	,
cord-002530-ao7kenbx	132	8	the	the	DT
cord-002530-ao7kenbx	132	9	expression	expression	NN
cord-002530-ao7kenbx	132	10	of	of	IN
cord-002530-ao7kenbx	132	11	a	a	DT
cord-002530-ao7kenbx	132	12	subset	subset	NN
cord-002530-ao7kenbx	132	13	of	of	IN
cord-002530-ao7kenbx	132	14	viral	viral	JJ
cord-002530-ao7kenbx	132	15	genes	gene	NNS
cord-002530-ao7kenbx	132	16	remained	remain	VBD
cord-002530-ao7kenbx	132	17	equivalent	equivalent	JJ
cord-002530-ao7kenbx	132	18	to	to	IN
cord-002530-ao7kenbx	132	19	control	control	NN
cord-002530-ao7kenbx	132	20	levels	level	NNS
cord-002530-ao7kenbx	132	21	following	follow	VBG
cord-002530-ao7kenbx	132	22	knockdown	knockdown	NN
cord-002530-ao7kenbx	132	23	of	of	IN
cord-002530-ao7kenbx	132	24	VCP	VCP	NNP
cord-002530-ao7kenbx	132	25	(	(	-LRB-
cord-002530-ao7kenbx	132	26	Fig	Fig	NNP
cord-002530-ao7kenbx	132	27	7	7	CD
cord-002530-ao7kenbx	132	28	and	and	CC
cord-002530-ao7kenbx	132	29	S7	S7	NNP
cord-002530-ao7kenbx	132	30	Fig	Fig	NNP
cord-002530-ao7kenbx	132	31	)	)	-RRB-
cord-002530-ao7kenbx	132	32	.	.	.
cord-002530-ao7kenbx	133	1	These	these	DT
cord-002530-ao7kenbx	133	2	include	include	VBP
cord-002530-ao7kenbx	133	3	UL21A	UL21A	VBN
cord-002530-ao7kenbx	133	4	,	,	,
cord-002530-ao7kenbx	133	5	UL36	UL36	NNP
cord-002530-ao7kenbx	133	6	and	and	CC
cord-002530-ao7kenbx	133	7	UL38	UL38	NNP
cord-002530-ao7kenbx	133	8	,	,	,
cord-002530-ao7kenbx	133	9	UL111A	ul111a	JJ
cord-002530-ao7kenbx	133	10	and	and	CC
cord-002530-ao7kenbx	133	11	UL112/113	UL112/113	NNS
cord-002530-ao7kenbx	133	12	,	,	,
cord-002530-ao7kenbx	133	13	UL123	UL123	NNP
cord-002530-ao7kenbx	133	14	(	(	-LRB-
cord-002530-ao7kenbx	133	15	IE1	ie1	NN
cord-002530-ao7kenbx	133	16	)	)	-RRB-
cord-002530-ao7kenbx	133	17	and	and	CC
cord-002530-ao7kenbx	133	18	UL144	UL144	NNS
cord-002530-ao7kenbx	133	19	.	.	.
cord-002530-ao7kenbx	134	1	This	this	DT
cord-002530-ao7kenbx	134	2	is	be	VBZ
cord-002530-ao7kenbx	134	3	particularly	particularly	RB
cord-002530-ao7kenbx	134	4	surprising	surprising	JJ
cord-002530-ao7kenbx	134	5	for	for	IN
cord-002530-ao7kenbx	134	6	UL112/113	UL112/113	NNS
cord-002530-ao7kenbx	134	7	which	which	WDT
cord-002530-ao7kenbx	134	8	has	have	VBZ
cord-002530-ao7kenbx	134	9	previously	previously	RB
cord-002530-ao7kenbx	134	10	been	be	VBN
cord-002530-ao7kenbx	134	11	identified	identify	VBN
cord-002530-ao7kenbx	134	12	as	as	IN
cord-002530-ao7kenbx	134	13	a	a	DT
cord-002530-ao7kenbx	134	14	target	target	NN
cord-002530-ao7kenbx	134	15	for	for	IN
cord-002530-ao7kenbx	134	16	IE2	ie2	JJ
cord-002530-ao7kenbx	134	17	transactivation	transactivation	NN
cord-002530-ao7kenbx	134	18	[	[	-LRB-
cord-002530-ao7kenbx	134	19	31	31	CD
cord-002530-ao7kenbx	134	20	,	,	,
cord-002530-ao7kenbx	134	21	32	32	CD
cord-002530-ao7kenbx	134	22	]	]	-RRB-
cord-002530-ao7kenbx	134	23	.	.	.
cord-002530-ao7kenbx	135	1	VCP	VCP	NNP
cord-002530-ao7kenbx	135	2	is	be	VBZ
cord-002530-ao7kenbx	135	3	essential	essential	JJ
cord-002530-ao7kenbx	135	4	for	for	IN
cord-002530-ao7kenbx	135	5	HCMV	HCMV	NNP
cord-002530-ao7kenbx	135	6	replication	replication	NN
cord-002530-ao7kenbx	135	7	Altered	alter	VBN
cord-002530-ao7kenbx	135	8	MIE	mie	NN
cord-002530-ao7kenbx	135	9	splicing	splicing	NN
cord-002530-ao7kenbx	135	10	is	be	VBZ
cord-002530-ao7kenbx	135	11	not	not	RB
cord-002530-ao7kenbx	135	12	due	due	JJ
cord-002530-ao7kenbx	135	13	to	to	IN
cord-002530-ao7kenbx	135	14	changes	change	NNS
cord-002530-ao7kenbx	135	15	in	in	IN
cord-002530-ao7kenbx	135	16	cell	cell	NN
cord-002530-ao7kenbx	135	17	cycle	cycle	NN
cord-002530-ao7kenbx	135	18	or	or	CC
cord-002530-ao7kenbx	135	19	delay	delay	VB
cord-002530-ao7kenbx	135	20	in	in	IN
cord-002530-ao7kenbx	135	21	replication	replication	NN
cord-002530-ao7kenbx	135	22	progression	progression	NN
cord-002530-ao7kenbx	135	23	following	follow	VBG
cord-002530-ao7kenbx	135	24	VCP	VCP	NNP
cord-002530-ao7kenbx	135	25	knockdown	knockdown	NN
cord-002530-ao7kenbx	135	26	Previous	previous	JJ
cord-002530-ao7kenbx	135	27	studies	study	NNS
cord-002530-ao7kenbx	135	28	have	have	VBP
cord-002530-ao7kenbx	135	29	shown	show	VBN
cord-002530-ao7kenbx	135	30	that	that	IN
cord-002530-ao7kenbx	135	31	the	the	DT
cord-002530-ao7kenbx	135	32	cell	cell	NN
cord-002530-ao7kenbx	135	33	cycle	cycle	NN
cord-002530-ao7kenbx	135	34	impacts	impact	NNS
cord-002530-ao7kenbx	135	35	on	on	IN
cord-002530-ao7kenbx	135	36	the	the	DT
cord-002530-ao7kenbx	135	37	regulation	regulation	NN
cord-002530-ao7kenbx	135	38	of	of	IN
cord-002530-ao7kenbx	135	39	MIE	MIE	NNP
cord-002530-ao7kenbx	135	40	alternative	alternative	NN
cord-002530-ao7kenbx	135	41	splicing	splicing	NN
cord-002530-ao7kenbx	135	42	with	with	IN
cord-002530-ao7kenbx	135	43	IE2	ie2	JJ
cord-002530-ao7kenbx	135	44	splicing	splicing	NN
cord-002530-ao7kenbx	135	45	and	and	CC
cord-002530-ao7kenbx	135	46	virus	virus	NN
cord-002530-ao7kenbx	135	47	replication	replication	NN
cord-002530-ao7kenbx	135	48	blocked	block	VBN
cord-002530-ao7kenbx	135	49	at	at	IN
cord-002530-ao7kenbx	135	50	the	the	DT
cord-002530-ao7kenbx	135	51	G2	G2	NNP
cord-002530-ao7kenbx	135	52	/	/	SYM
cord-002530-ao7kenbx	135	53	M	M	NNP
cord-002530-ao7kenbx	135	54	phase	phase	NN
cord-002530-ao7kenbx	135	55	[	[	-LRB-
cord-002530-ao7kenbx	135	56	33	33	CD
cord-002530-ao7kenbx	135	57	]	]	-RRB-
cord-002530-ao7kenbx	135	58	.	.	.
cord-002530-ao7kenbx	136	1	Furthermore	furthermore	RB
cord-002530-ao7kenbx	136	2	,	,	,
cord-002530-ao7kenbx	136	3	cyclin	cyclin	NN
cord-002530-ao7kenbx	136	4	dependent	dependent	JJ
cord-002530-ao7kenbx	136	5	kinases	kinase	NNS
cord-002530-ao7kenbx	136	6	are	be	VBP
cord-002530-ao7kenbx	136	7	required	require	VBN
cord-002530-ao7kenbx	136	8	for	for	IN
cord-002530-ao7kenbx	136	9	efficient	efficient	JJ
cord-002530-ao7kenbx	136	10	IE2	ie2	JJ
cord-002530-ao7kenbx	136	11	expression	expression	NN
cord-002530-ao7kenbx	136	12	and	and	CC
cord-002530-ao7kenbx	136	13	cyclin	cyclin	NN
cord-002530-ao7kenbx	136	14	A2	A2	NNP
cord-002530-ao7kenbx	136	15	overexpression	overexpression	NN
cord-002530-ao7kenbx	136	16	inhibits	inhibit	VBZ
cord-002530-ao7kenbx	136	17	IE2	ie2	NN
cord-002530-ao7kenbx	136	18	splicing	splicing	NN
cord-002530-ao7kenbx	136	19	and	and	CC
cord-002530-ao7kenbx	136	20	virus	virus	NN
cord-002530-ao7kenbx	136	21	replication	replication	NN
cord-002530-ao7kenbx	136	22	[	[	-LRB-
cord-002530-ao7kenbx	136	23	34	34	CD
cord-002530-ao7kenbx	136	24	]	]	-RRB-
cord-002530-ao7kenbx	136	25	.	.	.
cord-002530-ao7kenbx	137	1	To	to	TO
cord-002530-ao7kenbx	137	2	determine	determine	VB
cord-002530-ao7kenbx	137	3	whether	whether	IN
cord-002530-ao7kenbx	137	4	knockdown	knockdown	NN
cord-002530-ao7kenbx	137	5	of	of	IN
cord-002530-ao7kenbx	137	6	VCP	VCP	NNP
cord-002530-ao7kenbx	137	7	results	result	NNS
cord-002530-ao7kenbx	137	8	in	in	IN
cord-002530-ao7kenbx	137	9	alterations	alteration	NNS
cord-002530-ao7kenbx	137	10	in	in	IN
cord-002530-ao7kenbx	137	11	cell	cell	NN
cord-002530-ao7kenbx	137	12	cycle	cycle	NN
cord-002530-ao7kenbx	137	13	,	,	,
cord-002530-ao7kenbx	137	14	which	which	WDT
cord-002530-ao7kenbx	137	15	in	in	IN
cord-002530-ao7kenbx	137	16	turn	turn	NN
cord-002530-ao7kenbx	137	17	regulates	regulate	VBZ
cord-002530-ao7kenbx	137	18	MIE	MIE	NNP
cord-002530-ao7kenbx	137	19	splicing	splicing	NN
cord-002530-ao7kenbx	137	20	,	,	,
cord-002530-ao7kenbx	137	21	cells	cell	NNS
cord-002530-ao7kenbx	137	22	were	be	VBD
cord-002530-ao7kenbx	137	23	stained	stain	VBN
cord-002530-ao7kenbx	137	24	with	with	IN
cord-002530-ao7kenbx	137	25	propidium	propidium	NN
cord-002530-ao7kenbx	137	26	iodide	iodide	NN
cord-002530-ao7kenbx	137	27	following	follow	VBG
cord-002530-ao7kenbx	137	28	VCP	VCP	NNP
cord-002530-ao7kenbx	137	29	knockdown	knockdown	NN
cord-002530-ao7kenbx	137	30	.	.	.
cord-002530-ao7kenbx	138	1	The	the	DT
cord-002530-ao7kenbx	138	2	results	result	NNS
cord-002530-ao7kenbx	138	3	clearly	clearly	RB
cord-002530-ao7kenbx	138	4	show	show	VBP
cord-002530-ao7kenbx	138	5	that	that	IN
cord-002530-ao7kenbx	138	6	knockdown	knockdown	NN
cord-002530-ao7kenbx	138	7	of	of	IN
cord-002530-ao7kenbx	138	8	VCP	VCP	NNP
cord-002530-ao7kenbx	138	9	has	have	VBZ
cord-002530-ao7kenbx	138	10	no	no	DT
cord-002530-ao7kenbx	138	11	gross	gross	JJ
cord-002530-ao7kenbx	138	12	effect	effect	NN
cord-002530-ao7kenbx	138	13	on	on	IN
cord-002530-ao7kenbx	138	14	cell	cell	NN
cord-002530-ao7kenbx	138	15	cycle	cycle	NN
cord-002530-ao7kenbx	138	16	control	control	NN
cord-002530-ao7kenbx	138	17	(	(	-LRB-
cord-002530-ao7kenbx	138	18	Fig	Fig	NNP
cord-002530-ao7kenbx	138	19	8)	8)	NN
cord-002530-ao7kenbx	138	20	.	.	.
cord-002530-ao7kenbx	139	1	Consistent	consistent	JJ
cord-002530-ao7kenbx	139	2	with	with	IN
cord-002530-ao7kenbx	139	3	the	the	DT
cord-002530-ao7kenbx	139	4	majority	majority	NN
cord-002530-ao7kenbx	139	5	of	of	IN
cord-002530-ao7kenbx	139	6	cells	cell	NNS
cord-002530-ao7kenbx	139	7	being	be	VBG
cord-002530-ao7kenbx	139	8	in	in	IN
cord-002530-ao7kenbx	139	9	G0	G0	NNP
cord-002530-ao7kenbx	139	10	/	/	SYM
cord-002530-ao7kenbx	139	11	G1	G1	NNP
cord-002530-ao7kenbx	139	12	phase	phase	NN
cord-002530-ao7kenbx	139	13	,	,	,
cord-002530-ao7kenbx	139	14	cyclin	cyclin	NN
cord-002530-ao7kenbx	139	15	A2	A2	NNP
cord-002530-ao7kenbx	139	16	levels	level	NNS
cord-002530-ao7kenbx	139	17	remained	remain	VBD
cord-002530-ao7kenbx	139	18	undetectable	undetectable	JJ
cord-002530-ao7kenbx	139	19	by	by	IN
cord-002530-ao7kenbx	139	20	western	western	JJ
cord-002530-ao7kenbx	139	21	blot	blot	NN
cord-002530-ao7kenbx	139	22	in	in	IN
cord-002530-ao7kenbx	139	23	control	control	NN
cord-002530-ao7kenbx	139	24	and	and	CC
cord-002530-ao7kenbx	139	25	VCP	VCP	NNP
cord-002530-ao7kenbx	139	26	knockdown	knockdown	NN
cord-002530-ao7kenbx	139	27	cells	cell	NNS
cord-002530-ao7kenbx	139	28	(	(	-LRB-
cord-002530-ao7kenbx	139	29	S8	S8	NNP
cord-002530-ao7kenbx	139	30	Fig	Fig	NNP
cord-002530-ao7kenbx	139	31	)	)	-RRB-
cord-002530-ao7kenbx	139	32	.	.	.
cord-002530-ao7kenbx	140	1	These	these	DT
cord-002530-ao7kenbx	140	2	results	result	NNS
cord-002530-ao7kenbx	140	3	show	show	VBP
cord-002530-ao7kenbx	140	4	that	that	IN
cord-002530-ao7kenbx	140	5	regulation	regulation	NN
cord-002530-ao7kenbx	140	6	of	of	IN
cord-002530-ao7kenbx	140	7	MIE	MIE	NNP
cord-002530-ao7kenbx	140	8	splicing	splicing	NN
cord-002530-ao7kenbx	140	9	by	by	IN
cord-002530-ao7kenbx	140	10	VCP	VCP	NNP
cord-002530-ao7kenbx	140	11	is	be	VBZ
cord-002530-ao7kenbx	140	12	not	not	RB
cord-002530-ao7kenbx	140	13	a	a	DT
cord-002530-ao7kenbx	140	14	consequence	consequence	NN
cord-002530-ao7kenbx	140	15	of	of	IN
cord-002530-ao7kenbx	140	16	alterations	alteration	NNS
cord-002530-ao7kenbx	140	17	in	in	IN
cord-002530-ao7kenbx	140	18	cell	cell	NN
cord-002530-ao7kenbx	140	19	cycle	cycle	NN
cord-002530-ao7kenbx	140	20	control	control	NN
cord-002530-ao7kenbx	140	21	and	and	CC
cord-002530-ao7kenbx	140	22	instead	instead	RB
cord-002530-ao7kenbx	140	23	represents	represent	VBZ
cord-002530-ao7kenbx	140	24	a	a	DT
cord-002530-ao7kenbx	140	25	novel	novel	JJ
cord-002530-ao7kenbx	140	26	regulatory	regulatory	JJ
cord-002530-ao7kenbx	140	27	pathway	pathway	NN
cord-002530-ao7kenbx	140	28	.	.	.
cord-002530-ao7kenbx	141	1	To	to	TO
cord-002530-ao7kenbx	141	2	determine	determine	VB
cord-002530-ao7kenbx	141	3	whether	whether	IN
cord-002530-ao7kenbx	141	4	the	the	DT
cord-002530-ao7kenbx	141	5	effect	effect	NN
cord-002530-ao7kenbx	141	6	of	of	IN
cord-002530-ao7kenbx	141	7	VCP	VCP	NNP
cord-002530-ao7kenbx	141	8	on	on	IN
cord-002530-ao7kenbx	141	9	MIE	MIE	NNP
cord-002530-ao7kenbx	141	10	expression	expression	NN
cord-002530-ao7kenbx	141	11	could	could	MD
cord-002530-ao7kenbx	141	12	be	be	VB
cord-002530-ao7kenbx	141	13	the	the	DT
cord-002530-ao7kenbx	141	14	result	result	NN
cord-002530-ao7kenbx	141	15	of	of	IN
cord-002530-ao7kenbx	141	16	a	a	DT
cord-002530-ao7kenbx	141	17	simple	simple	JJ
cord-002530-ao7kenbx	141	18	delay	delay	NN
cord-002530-ao7kenbx	141	19	or	or	CC
cord-002530-ao7kenbx	141	20	inhibition	inhibition	NN
cord-002530-ao7kenbx	141	21	of	of	IN
cord-002530-ao7kenbx	141	22	progression	progression	NN
cord-002530-ao7kenbx	141	23	in	in	IN
cord-002530-ao7kenbx	141	24	virus	virus	NN
cord-002530-ao7kenbx	141	25	replication	replication	NN
cord-002530-ao7kenbx	141	26	,	,	,
cord-002530-ao7kenbx	141	27	we	-PRON-	PRP
cord-002530-ao7kenbx	141	28	compared	compare	VBD
cord-002530-ao7kenbx	141	29	MIE	MIE	NNP
cord-002530-ao7kenbx	141	30	protein	protein	NN
cord-002530-ao7kenbx	141	31	and	and	CC
cord-002530-ao7kenbx	141	32	transcript	transcript	NN
cord-002530-ao7kenbx	141	33	levels	level	NNS
cord-002530-ao7kenbx	141	34	following	follow	VBG
cord-002530-ao7kenbx	141	35	treatment	treatment	NN
cord-002530-ao7kenbx	141	36	of	of	IN
cord-002530-ao7kenbx	141	37	cells	cell	NNS
cord-002530-ao7kenbx	141	38	with	with	IN
cord-002530-ao7kenbx	141	39	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	141	40	,	,	,
cord-002530-ao7kenbx	141	41	a	a	DT
cord-002530-ao7kenbx	141	42	well	well	RB
cord-002530-ao7kenbx	141	43	characterized	characterize	VBN
cord-002530-ao7kenbx	141	44	drug	drug	NN
cord-002530-ao7kenbx	141	45	,	,	,
cord-002530-ao7kenbx	141	46	which	which	WDT
cord-002530-ao7kenbx	141	47	inhibits	inhibit	VBZ
cord-002530-ao7kenbx	141	48	viral	viral	JJ
cord-002530-ao7kenbx	141	49	DNA	dna	NN
cord-002530-ao7kenbx	141	50	synthesis	synthesis	NN
cord-002530-ao7kenbx	141	51	.	.	.
cord-002530-ao7kenbx	142	1	While	while	IN
cord-002530-ao7kenbx	142	2	both	both	DT
cord-002530-ao7kenbx	142	3	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	142	4	treatment	treatment	NN
cord-002530-ao7kenbx	142	5	and	and	CC
cord-002530-ao7kenbx	142	6	VCP	VCP	NNP
cord-002530-ao7kenbx	142	7	knockdown	knockdown	NN
cord-002530-ao7kenbx	142	8	result	result	NN
cord-002530-ao7kenbx	142	9	in	in	IN
cord-002530-ao7kenbx	142	10	substantial	substantial	JJ
cord-002530-ao7kenbx	142	11	reductions	reduction	NNS
cord-002530-ao7kenbx	142	12	in	in	IN
cord-002530-ao7kenbx	142	13	IE2	ie2	JJ
cord-002530-ao7kenbx	142	14	gene	gene	NN
cord-002530-ao7kenbx	142	15	expression	expression	NN
cord-002530-ao7kenbx	142	16	,	,	,
cord-002530-ao7kenbx	142	17	only	only	RB
cord-002530-ao7kenbx	142	18	knockdown	knockdown	NN
cord-002530-ao7kenbx	142	19	of	of	IN
cord-002530-ao7kenbx	142	20	VCP	VCP	NNP
cord-002530-ao7kenbx	142	21	results	result	NNS
cord-002530-ao7kenbx	142	22	in	in	IN
cord-002530-ao7kenbx	142	23	a	a	DT
cord-002530-ao7kenbx	142	24	corresponding	corresponding	JJ
cord-002530-ao7kenbx	142	25	increase	increase	NN
cord-002530-ao7kenbx	142	26	in	in	IN
cord-002530-ao7kenbx	142	27	IE1	ie1	NN
cord-002530-ao7kenbx	142	28	gene	gene	NN
cord-002530-ao7kenbx	142	29	expression	expression	NN
cord-002530-ao7kenbx	142	30	and	and	CC
cord-002530-ao7kenbx	142	31	relative	relative	JJ
cord-002530-ao7kenbx	142	32	changes	change	NNS
cord-002530-ao7kenbx	142	33	in	in	IN
cord-002530-ao7kenbx	142	34	IE1	ie1	NN
cord-002530-ao7kenbx	142	35	and	and	CC
cord-002530-ao7kenbx	142	36	IE2	ie2	NN
cord-002530-ao7kenbx	142	37	splicing	splicing	NN
cord-002530-ao7kenbx	142	38	(	(	-LRB-
cord-002530-ao7kenbx	142	39	S9	S9	NNP
cord-002530-ao7kenbx	142	40	Fig	Fig	NNP
cord-002530-ao7kenbx	142	41	)	)	-RRB-
cord-002530-ao7kenbx	142	42	.	.	.
cord-002530-ao7kenbx	143	1	Furthermore	furthermore	RB
cord-002530-ao7kenbx	143	2	,	,	,
cord-002530-ao7kenbx	143	3	in	in	IN
cord-002530-ao7kenbx	143	4	contrast	contrast	NN
cord-002530-ao7kenbx	143	5	to	to	IN
cord-002530-ao7kenbx	143	6	VCP	VCP	NNP
cord-002530-ao7kenbx	143	7	knockdown	knockdown	NN
cord-002530-ao7kenbx	143	8	,	,	,
cord-002530-ao7kenbx	143	9	IE2	ie2	NN
cord-002530-ao7kenbx	143	10	and	and	CC
cord-002530-ao7kenbx	143	11	pp52	pp52	NNP
cord-002530-ao7kenbx	143	12	expression	expression	NN
cord-002530-ao7kenbx	143	13	could	could	MD
cord-002530-ao7kenbx	143	14	be	be	VB
cord-002530-ao7kenbx	143	15	detected	detect	VBN
cord-002530-ao7kenbx	143	16	four	four	CD
cord-002530-ao7kenbx	143	17	days	day	NNS
cord-002530-ao7kenbx	143	18	post	post	NN
cord-002530-ao7kenbx	143	19	infection	infection	NN
cord-002530-ao7kenbx	143	20	following	follow	VBG
cord-002530-ao7kenbx	143	21	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	143	22	treatment	treatment	NN
cord-002530-ao7kenbx	143	23	.	.	.
cord-002530-ao7kenbx	144	1	These	these	DT
cord-002530-ao7kenbx	144	2	data	datum	NNS
cord-002530-ao7kenbx	144	3	suggest	suggest	VBP
cord-002530-ao7kenbx	144	4	alterations	alteration	NNS
cord-002530-ao7kenbx	144	5	in	in	IN
cord-002530-ao7kenbx	144	6	MIE	MIE	NNP
cord-002530-ao7kenbx	144	7	levels	level	NNS
cord-002530-ao7kenbx	144	8	,	,	,
cord-002530-ao7kenbx	144	9	caused	cause	VBN
cord-002530-ao7kenbx	144	10	by	by	IN
cord-002530-ao7kenbx	144	11	VCP	VCP	NNP
cord-002530-ao7kenbx	144	12	knockdown	knockdown	NN
cord-002530-ao7kenbx	144	13	are	be	VBP
cord-002530-ao7kenbx	144	14	not	not	RB
cord-002530-ao7kenbx	144	15	an	an	DT
cord-002530-ao7kenbx	144	16	artifact	artifact	NN
cord-002530-ao7kenbx	144	17	of	of	IN
cord-002530-ao7kenbx	144	18	delayed	delay	VBN
cord-002530-ao7kenbx	144	19	virus	virus	NN
cord-002530-ao7kenbx	144	20	replication	replication	NN
cord-002530-ao7kenbx	144	21	.	.	.
cord-002530-ao7kenbx	145	1	Previous	previous	JJ
cord-002530-ao7kenbx	145	2	studies	study	NNS
cord-002530-ao7kenbx	145	3	have	have	VBP
cord-002530-ao7kenbx	145	4	demonstrated	demonstrate	VBN
cord-002530-ao7kenbx	145	5	that	that	IN
cord-002530-ao7kenbx	145	6	VCP	VCP	NNP
cord-002530-ao7kenbx	145	7	plays	play	VBZ
cord-002530-ao7kenbx	145	8	an	an	DT
cord-002530-ao7kenbx	145	9	important	important	JJ
cord-002530-ao7kenbx	145	10	role	role	NN
cord-002530-ao7kenbx	145	11	in	in	IN
cord-002530-ao7kenbx	145	12	the	the	DT
cord-002530-ao7kenbx	145	13	cytoplasm	cytoplasm	NN
cord-002530-ao7kenbx	145	14	of	of	IN
cord-002530-ao7kenbx	145	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	145	16	infected	infected	JJ
cord-002530-ao7kenbx	145	17	cells	cell	NNS
cord-002530-ao7kenbx	145	18	,	,	,
cord-002530-ao7kenbx	145	19	mediating	mediate	VBG
cord-002530-ao7kenbx	145	20	US11-dependent	us11-dependent	CD
cord-002530-ao7kenbx	145	21	degradation	degradation	NN
cord-002530-ao7kenbx	145	22	of	of	IN
cord-002530-ao7kenbx	145	23	MHC	MHC	NNP
cord-002530-ao7kenbx	145	24	class	class	NN
cord-002530-ao7kenbx	145	25	I	i	NN
cord-002530-ao7kenbx	145	26	,	,	,
cord-002530-ao7kenbx	145	27	by	by	IN
cord-002530-ao7kenbx	145	28	stripping	strip	VBG
cord-002530-ao7kenbx	145	29	the	the	DT
cord-002530-ao7kenbx	145	30	protein	protein	NN
cord-002530-ao7kenbx	145	31	from	from	IN
cord-002530-ao7kenbx	145	32	the	the	DT
cord-002530-ao7kenbx	145	33	ER	ER	NNP
cord-002530-ao7kenbx	145	34	membrane	membrane	NN
cord-002530-ao7kenbx	145	35	in	in	IN
cord-002530-ao7kenbx	145	36	a	a	DT
cord-002530-ao7kenbx	145	37	ubiquitin	ubiquitin	JJ
cord-002530-ao7kenbx	145	38	dependent	dependent	JJ
cord-002530-ao7kenbx	145	39	manner	manner	NN
cord-002530-ao7kenbx	145	40	[	[	-LRB-
cord-002530-ao7kenbx	145	41	27	27	CD
cord-002530-ao7kenbx	145	42	]	]	-RRB-
cord-002530-ao7kenbx	145	43	.	.	.
cord-002530-ao7kenbx	146	1	To	to	TO
cord-002530-ao7kenbx	146	2	determine	determine	VB
cord-002530-ao7kenbx	146	3	the	the	DT
cord-002530-ao7kenbx	146	4	cellular	cellular	JJ
cord-002530-ao7kenbx	146	5	localisation	localisation	NN
cord-002530-ao7kenbx	146	6	of	of	IN
cord-002530-ao7kenbx	146	7	VCP	VCP	NNP
cord-002530-ao7kenbx	146	8	during	during	IN
cord-002530-ao7kenbx	146	9	HCMV	HCMV	NNP
cord-002530-ao7kenbx	146	10	infection	infection	NN
cord-002530-ao7kenbx	146	11	,	,	,
cord-002530-ao7kenbx	146	12	primary	primary	JJ
cord-002530-ao7kenbx	146	13	fibroblast	fibroblast	NN
cord-002530-ao7kenbx	146	14	cells	cell	NNS
cord-002530-ao7kenbx	146	15	were	be	VBD
cord-002530-ao7kenbx	146	16	infected	infect	VBN
cord-002530-ao7kenbx	146	17	at	at	IN
cord-002530-ao7kenbx	146	18	high	high	JJ
cord-002530-ao7kenbx	146	19	MOI	MOI	NNP
cord-002530-ao7kenbx	146	20	with	with	IN
cord-002530-ao7kenbx	146	21	HCMV	HCMV	NNP
cord-002530-ao7kenbx	146	22	,	,	,
cord-002530-ao7kenbx	146	23	fixed	fix	VBN
cord-002530-ao7kenbx	146	24	at	at	IN
cord-002530-ao7kenbx	146	25	24-hour	24-hour	JJ
cord-002530-ao7kenbx	146	26	time	time	NN
cord-002530-ao7kenbx	146	27	points	point	NNS
cord-002530-ao7kenbx	146	28	and	and	CC
cord-002530-ao7kenbx	146	29	stained	stain	VBN
cord-002530-ao7kenbx	146	30	for	for	IN
cord-002530-ao7kenbx	146	31	VCP	VCP	NNP
cord-002530-ao7kenbx	146	32	.	.	.
cord-002530-ao7kenbx	147	1	As	as	IN
cord-002530-ao7kenbx	147	2	shown	show	VBN
cord-002530-ao7kenbx	147	3	in	in	IN
cord-002530-ao7kenbx	147	4	Fig	Fig	NNP
cord-002530-ao7kenbx	147	5	9	9	CD
cord-002530-ao7kenbx	147	6	,	,	,
cord-002530-ao7kenbx	147	7	VCP	VCP	NNP
cord-002530-ao7kenbx	147	8	displayed	display	VBD
cord-002530-ao7kenbx	147	9	dynamic	dynamic	JJ
cord-002530-ao7kenbx	147	10	temporal	temporal	JJ
cord-002530-ao7kenbx	147	11	cellular	cellular	JJ
cord-002530-ao7kenbx	147	12	localisation	localisation	NN
cord-002530-ao7kenbx	147	13	during	during	IN
cord-002530-ao7kenbx	147	14	HCMV	HCMV	NNP
cord-002530-ao7kenbx	147	15	infection	infection	NN
cord-002530-ao7kenbx	147	16	.	.	.
cord-002530-ao7kenbx	148	1	In	in	IN
cord-002530-ao7kenbx	148	2	uninfected	uninfected	JJ
cord-002530-ao7kenbx	148	3	cells	cell	NNS
cord-002530-ao7kenbx	148	4	,	,	,
cord-002530-ao7kenbx	148	5	VCP	VCP	NNP
cord-002530-ao7kenbx	148	6	staining	staining	NN
cord-002530-ao7kenbx	148	7	resulted	result	VBD
cord-002530-ao7kenbx	148	8	in	in	IN
cord-002530-ao7kenbx	148	9	diffuse	diffuse	JJ
cord-002530-ao7kenbx	148	10	signal	signal	NN
cord-002530-ao7kenbx	148	11	throughout	throughout	IN
cord-002530-ao7kenbx	148	12	the	the	DT
cord-002530-ao7kenbx	148	13	cell	cell	NN
cord-002530-ao7kenbx	148	14	.	.	.
cord-002530-ao7kenbx	149	1	However	however	RB
cord-002530-ao7kenbx	149	2	following	follow	VBG
cord-002530-ao7kenbx	149	3	infection	infection	NN
cord-002530-ao7kenbx	149	4	with	with	IN
cord-002530-ao7kenbx	149	5	HCMV	HCMV	NNP
cord-002530-ao7kenbx	149	6	,	,	,
cord-002530-ao7kenbx	149	7	distinct	distinct	JJ
cord-002530-ao7kenbx	149	8	puncta	puncta	NN
cord-002530-ao7kenbx	149	9	can	can	MD
cord-002530-ao7kenbx	149	10	be	be	VB
cord-002530-ao7kenbx	149	11	observed	observe	VBN
cord-002530-ao7kenbx	149	12	in	in	IN
cord-002530-ao7kenbx	149	13	the	the	DT
cord-002530-ao7kenbx	149	14	nucleus	nucleus	NN
cord-002530-ao7kenbx	149	15	of	of	IN
cord-002530-ao7kenbx	149	16	infected	infected	JJ
cord-002530-ao7kenbx	149	17	cells	cell	NNS
cord-002530-ao7kenbx	149	18	.	.	.
cord-002530-ao7kenbx	150	1	By	by	IN
cord-002530-ao7kenbx	150	2	48	48	CD
cord-002530-ao7kenbx	150	3	HPI	HPI	NNP
cord-002530-ao7kenbx	150	4	VCP	VCP	NNP
cord-002530-ao7kenbx	150	5	was	be	VBD
cord-002530-ao7kenbx	150	6	consistently	consistently	RB
cord-002530-ao7kenbx	150	7	found	find	VBN
cord-002530-ao7kenbx	150	8	within	within	IN
cord-002530-ao7kenbx	150	9	two	two	CD
cord-002530-ao7kenbx	150	10	large	large	JJ
cord-002530-ao7kenbx	150	11	puncta	puncta	NN
cord-002530-ao7kenbx	150	12	within	within	IN
cord-002530-ao7kenbx	150	13	the	the	DT
cord-002530-ao7kenbx	150	14	nucleus	nucleus	NN
cord-002530-ao7kenbx	150	15	,	,	,
cord-002530-ao7kenbx	150	16	which	which	WDT
cord-002530-ao7kenbx	150	17	increased	increase	VBD
cord-002530-ao7kenbx	150	18	in	in	IN
cord-002530-ao7kenbx	150	19	size	size	NN
cord-002530-ao7kenbx	150	20	by	by	IN
cord-002530-ao7kenbx	150	21	72	72	CD
cord-002530-ao7kenbx	150	22	hours	hour	NNS
cord-002530-ao7kenbx	150	23	.	.	.
cord-002530-ao7kenbx	151	1	Such	such	JJ
cord-002530-ao7kenbx	151	2	staining	staining	NN
cord-002530-ao7kenbx	151	3	is	be	VBZ
cord-002530-ao7kenbx	151	4	characteristic	characteristic	JJ
cord-002530-ao7kenbx	151	5	of	of	IN
cord-002530-ao7kenbx	151	6	the	the	DT
cord-002530-ao7kenbx	151	7	viral	viral	JJ
cord-002530-ao7kenbx	151	8	replication	replication	NN
cord-002530-ao7kenbx	151	9	compartments	compartment	NNS
cord-002530-ao7kenbx	151	10	.	.	.
cord-002530-ao7kenbx	152	1	Following	follow	VBG
cord-002530-ao7kenbx	152	2	infection	infection	NN
cord-002530-ao7kenbx	152	3	with	with	IN
cord-002530-ao7kenbx	152	4	HCMV	HCMV	NNP
cord-002530-ao7kenbx	152	5	the	the	DT
cord-002530-ao7kenbx	152	6	viral	viral	JJ
cord-002530-ao7kenbx	152	7	genomes	genome	NNS
cord-002530-ao7kenbx	152	8	are	be	VBP
cord-002530-ao7kenbx	152	9	deposited	deposit	VBN
cord-002530-ao7kenbx	152	10	adjacent	adjacent	JJ
cord-002530-ao7kenbx	152	11	to	to	IN
cord-002530-ao7kenbx	152	12	ND10	ND10	NNP
cord-002530-ao7kenbx	152	13	domains	domain	NNS
cord-002530-ao7kenbx	152	14	before	before	IN
cord-002530-ao7kenbx	152	15	forming	form	VBG
cord-002530-ao7kenbx	152	16	two	two	CD
cord-002530-ao7kenbx	152	17	distinct	distinct	JJ
cord-002530-ao7kenbx	152	18	replication	replication	NN
cord-002530-ao7kenbx	152	19	compartments	compartment	NNS
cord-002530-ao7kenbx	152	20	within	within	IN
cord-002530-ao7kenbx	152	21	the	the	DT
cord-002530-ao7kenbx	152	22	nucleus	nucleus	NN
cord-002530-ao7kenbx	152	23	,	,	,
cord-002530-ao7kenbx	152	24	characterized	characterize	VBN
cord-002530-ao7kenbx	152	25	by	by	IN
cord-002530-ao7kenbx	152	26	colocalisation	colocalisation	NN
cord-002530-ao7kenbx	152	27	of	of	IN
cord-002530-ao7kenbx	152	28	viral	viral	JJ
cord-002530-ao7kenbx	152	29	DNA	dna	NN
cord-002530-ao7kenbx	152	30	,	,	,
cord-002530-ao7kenbx	152	31	DNA	dna	NN
cord-002530-ao7kenbx	152	32	replication	replication	NN
cord-002530-ao7kenbx	152	33	proteins	protein	NNS
cord-002530-ao7kenbx	152	34	and	and	CC
cord-002530-ao7kenbx	152	35	IE2	ie2	NN
cord-002530-ao7kenbx	152	36	protein	protein	NN
cord-002530-ao7kenbx	152	37	[	[	-LRB-
cord-002530-ao7kenbx	152	38	35	35	CD
cord-002530-ao7kenbx	152	39	]	]	-RRB-
cord-002530-ao7kenbx	152	40	.	.	.
cord-002530-ao7kenbx	153	1	Therefore	therefore	RB
cord-002530-ao7kenbx	153	2	,	,	,
cord-002530-ao7kenbx	153	3	VCP	VCP	NNP
cord-002530-ao7kenbx	153	4	localisation	localisation	NN
cord-002530-ao7kenbx	153	5	to	to	IN
cord-002530-ao7kenbx	153	6	the	the	DT
cord-002530-ao7kenbx	153	7	virus	virus	NN
cord-002530-ao7kenbx	153	8	replication	replication	NN
cord-002530-ao7kenbx	153	9	compartments	compartment	NNS
cord-002530-ao7kenbx	153	10	in	in	IN
cord-002530-ao7kenbx	153	11	the	the	DT
cord-002530-ao7kenbx	153	12	nucleus	nucleus	NN
cord-002530-ao7kenbx	153	13	coincides	coincide	VBZ
cord-002530-ao7kenbx	153	14	with	with	IN
cord-002530-ao7kenbx	153	15	increased	increase	VBN
cord-002530-ao7kenbx	153	16	IE2	ie2	JJ
cord-002530-ao7kenbx	153	17	expression	expression	NN
cord-002530-ao7kenbx	153	18	.	.	.
cord-002530-ao7kenbx	154	1	Given	give	VBN
cord-002530-ao7kenbx	154	2	that	that	IN
cord-002530-ao7kenbx	154	3	VCP	VCP	NNP
cord-002530-ao7kenbx	154	4	is	be	VBZ
cord-002530-ao7kenbx	154	5	essential	essential	JJ
cord-002530-ao7kenbx	154	6	for	for	IN
cord-002530-ao7kenbx	154	7	HCMV	HCMV	NNP
cord-002530-ao7kenbx	154	8	replication	replication	NN
cord-002530-ao7kenbx	154	9	,	,	,
cord-002530-ao7kenbx	154	10	we	-PRON-	PRP
cord-002530-ao7kenbx	154	11	investigated	investigate	VBD
cord-002530-ao7kenbx	154	12	whether	whether	IN
cord-002530-ao7kenbx	154	13	small	small	JJ
cord-002530-ao7kenbx	154	14	molecule	molecule	NN
cord-002530-ao7kenbx	154	15	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	154	16	against	against	IN
cord-002530-ao7kenbx	154	17	VCP	VCP	NNP
cord-002530-ao7kenbx	154	18	are	be	VBP
cord-002530-ao7kenbx	154	19	viable	viable	JJ
cord-002530-ao7kenbx	154	20	antiviral	antiviral	JJ
cord-002530-ao7kenbx	154	21	candidates	candidate	NNS
cord-002530-ao7kenbx	154	22	.	.	.
cord-002530-ao7kenbx	155	1	Because	because	IN
cord-002530-ao7kenbx	155	2	VCP	VCP	NNP
cord-002530-ao7kenbx	155	3	is	be	VBZ
cord-002530-ao7kenbx	155	4	a	a	DT
cord-002530-ao7kenbx	155	5	potential	potential	JJ
cord-002530-ao7kenbx	155	6	anti	anti	JJ
cord-002530-ao7kenbx	155	7	-	-	JJ
cord-002530-ao7kenbx	155	8	cancer	cancer	JJ
cord-002530-ao7kenbx	155	9	target	target	NN
cord-002530-ao7kenbx	155	10	,	,	,
cord-002530-ao7kenbx	155	11	a	a	DT
cord-002530-ao7kenbx	155	12	number	number	NN
cord-002530-ao7kenbx	155	13	of	of	IN
cord-002530-ao7kenbx	155	14	effective	effective	JJ
cord-002530-ao7kenbx	155	15	small	small	JJ
cord-002530-ao7kenbx	155	16	molecule	molecule	NN
cord-002530-ao7kenbx	155	17	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	155	18	of	of	IN
cord-002530-ao7kenbx	155	19	VCP	VCP	NNP
cord-002530-ao7kenbx	155	20	have	have	VBP
cord-002530-ao7kenbx	155	21	been	be	VBN
cord-002530-ao7kenbx	155	22	developed	develop	VBN
cord-002530-ao7kenbx	155	23	.	.	.
cord-002530-ao7kenbx	156	1	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	156	2	is	be	VBZ
cord-002530-ao7kenbx	156	3	a	a	DT
cord-002530-ao7kenbx	156	4	highly	highly	RB
cord-002530-ao7kenbx	156	5	potent	potent	JJ
cord-002530-ao7kenbx	156	6	and	and	CC
cord-002530-ao7kenbx	156	7	selective	selective	JJ
cord-002530-ao7kenbx	156	8	inhibitor	inhibitor	NN
cord-002530-ao7kenbx	156	9	of	of	IN
cord-002530-ao7kenbx	156	10	VCP	VCP	NNP
cord-002530-ao7kenbx	156	11	[	[	-LRB-
cord-002530-ao7kenbx	156	12	36	36	CD
cord-002530-ao7kenbx	156	13	]	]	-RRB-
cord-002530-ao7kenbx	156	14	.	.	.
cord-002530-ao7kenbx	157	1	To	to	TO
cord-002530-ao7kenbx	157	2	determine	determine	VB
cord-002530-ao7kenbx	157	3	whether	whether	IN
cord-002530-ao7kenbx	157	4	treatment	treatment	NN
cord-002530-ao7kenbx	157	5	of	of	IN
cord-002530-ao7kenbx	157	6	infected	infected	JJ
cord-002530-ao7kenbx	157	7	cells	cell	NNS
cord-002530-ao7kenbx	157	8	with	with	IN
cord-002530-ao7kenbx	157	9	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	157	10	results	result	NNS
cord-002530-ao7kenbx	157	11	in	in	IN
cord-002530-ao7kenbx	157	12	the	the	DT
cord-002530-ao7kenbx	157	13	same	same	JJ
cord-002530-ao7kenbx	157	14	phenotype	phenotype	NN
cord-002530-ao7kenbx	157	15	as	as	IN
cord-002530-ao7kenbx	157	16	VCP	VCP	NNP
cord-002530-ao7kenbx	157	17	siRNA	siRNA	NNP
cord-002530-ao7kenbx	157	18	knockdown	knockdown	NN
cord-002530-ao7kenbx	157	19	,	,	,
cord-002530-ao7kenbx	157	20	cells	cell	NNS
cord-002530-ao7kenbx	157	21	were	be	VBD
cord-002530-ao7kenbx	157	22	pretreated	pretreate	VBN
cord-002530-ao7kenbx	157	23	with	with	IN
cord-002530-ao7kenbx	157	24	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	157	25	or	or	CC
cord-002530-ao7kenbx	157	26	DMSO	DMSO	NNP
cord-002530-ao7kenbx	157	27	and	and	CC
cord-002530-ao7kenbx	157	28	infected	infect	VBN
cord-002530-ao7kenbx	157	29	at	at	IN
cord-002530-ao7kenbx	157	30	high	high	JJ
cord-002530-ao7kenbx	157	31	MOI	MOI	NNP
cord-002530-ao7kenbx	157	32	with	with	IN
cord-002530-ao7kenbx	157	33	HCMV	HCMV	NNP
cord-002530-ao7kenbx	157	34	.	.	.
cord-002530-ao7kenbx	158	1	Total	total	JJ
cord-002530-ao7kenbx	158	2	protein	protein	NN
cord-002530-ao7kenbx	158	3	was	be	VBD
cord-002530-ao7kenbx	158	4	harvested	harvest	VBN
cord-002530-ao7kenbx	158	5	every	every	DT
cord-002530-ao7kenbx	158	6	24	24	CD
cord-002530-ao7kenbx	158	7	hours	hour	NNS
cord-002530-ao7kenbx	158	8	for	for	IN
cord-002530-ao7kenbx	158	9	a	a	DT
cord-002530-ao7kenbx	158	10	total	total	NN
cord-002530-ao7kenbx	158	11	of	of	IN
cord-002530-ao7kenbx	158	12	five	five	CD
cord-002530-ao7kenbx	158	13	days	day	NNS
cord-002530-ao7kenbx	158	14	and	and	CC
cord-002530-ao7kenbx	158	15	subjected	subject	VBN
cord-002530-ao7kenbx	158	16	to	to	IN
cord-002530-ao7kenbx	158	17	western	western	JJ
cord-002530-ao7kenbx	158	18	blot	blot	NN
cord-002530-ao7kenbx	158	19	analysis	analysis	NN
cord-002530-ao7kenbx	158	20	.	.	.
cord-002530-ao7kenbx	159	1	As	as	IN
cord-002530-ao7kenbx	159	2	shown	show	VBN
cord-002530-ao7kenbx	159	3	in	in	IN
cord-002530-ao7kenbx	159	4	Fig	Fig	NNP
cord-002530-ao7kenbx	159	5	10A	10a	NN
cord-002530-ao7kenbx	159	6	,	,	,
cord-002530-ao7kenbx	159	7	treatment	treatment	NN
cord-002530-ao7kenbx	159	8	with	with	IN
cord-002530-ao7kenbx	159	9	1μM	1μm	CD
cord-002530-ao7kenbx	159	10	of	of	IN
cord-002530-ao7kenbx	159	11	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	159	12	recapitulated	recapitulate	VBD
cord-002530-ao7kenbx	159	13	the	the	DT
cord-002530-ao7kenbx	159	14	phenotypic	phenotypic	JJ
cord-002530-ao7kenbx	159	15	effects	effect	NNS
cord-002530-ao7kenbx	159	16	of	of	IN
cord-002530-ao7kenbx	159	17	VCP	VCP	NNP
cord-002530-ao7kenbx	159	18	siRNA	siRNA	NNP
cord-002530-ao7kenbx	159	19	,	,	,
cord-002530-ao7kenbx	159	20	with	with	IN
cord-002530-ao7kenbx	159	21	loss	loss	NN
cord-002530-ao7kenbx	159	22	of	of	IN
cord-002530-ao7kenbx	159	23	IE2	ie2	JJ
cord-002530-ao7kenbx	159	24	transcript	transcript	NN
cord-002530-ao7kenbx	159	25	and	and	CC
cord-002530-ao7kenbx	159	26	protein	protein	NN
cord-002530-ao7kenbx	159	27	expression	expression	NN
cord-002530-ao7kenbx	159	28	.	.	.
cord-002530-ao7kenbx	160	1	In	in	IN
cord-002530-ao7kenbx	160	2	contrast	contrast	NN
cord-002530-ao7kenbx	160	3	to	to	IN
cord-002530-ao7kenbx	160	4	siRNA	siRNA	NNP
cord-002530-ao7kenbx	160	5	knockdown	knockdown	NN
cord-002530-ao7kenbx	160	6	of	of	IN
cord-002530-ao7kenbx	160	7	VCP	VCP	NNP
cord-002530-ao7kenbx	160	8	,	,	,
cord-002530-ao7kenbx	160	9	treatment	treatment	NN
cord-002530-ao7kenbx	160	10	with	with	IN
cord-002530-ao7kenbx	160	11	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	160	12	did	do	VBD
cord-002530-ao7kenbx	160	13	not	not	RB
cord-002530-ao7kenbx	160	14	result	result	VB
cord-002530-ao7kenbx	160	15	in	in	IN
cord-002530-ao7kenbx	160	16	increased	increase	VBN
cord-002530-ao7kenbx	160	17	IE1	ie1	NN
cord-002530-ao7kenbx	160	18	expression	expression	NN
cord-002530-ao7kenbx	160	19	.	.	.
cord-002530-ao7kenbx	161	1	This	this	DT
cord-002530-ao7kenbx	161	2	may	may	MD
cord-002530-ao7kenbx	161	3	be	be	VB
cord-002530-ao7kenbx	161	4	due	due	JJ
cord-002530-ao7kenbx	161	5	to	to	TO
cord-002530-ao7kenbx	161	6	additional	additional	VB
cord-002530-ao7kenbx	161	7	off	off	RP
cord-002530-ao7kenbx	161	8	target	target	NN
cord-002530-ao7kenbx	161	9	effects	effect	NNS
cord-002530-ao7kenbx	161	10	of	of	IN
cord-002530-ao7kenbx	161	11	the	the	DT
cord-002530-ao7kenbx	161	12	drug	drug	NN
cord-002530-ao7kenbx	161	13	compared	compare	VBN
cord-002530-ao7kenbx	161	14	to	to	IN
cord-002530-ao7kenbx	161	15	siRNA	siRNA	NNP
cord-002530-ao7kenbx	161	16	knockdown	knockdown	NNP
cord-002530-ao7kenbx	161	17	or	or	CC
cord-002530-ao7kenbx	161	18	a	a	DT
cord-002530-ao7kenbx	161	19	consequence	consequence	NN
cord-002530-ao7kenbx	161	20	of	of	IN
cord-002530-ao7kenbx	161	21	inhibiting	inhibit	VBG
cord-002530-ao7kenbx	161	22	the	the	DT
cord-002530-ao7kenbx	161	23	activity	activity	NN
cord-002530-ao7kenbx	161	24	of	of	IN
cord-002530-ao7kenbx	161	25	VCP	vcp	NN
cord-002530-ao7kenbx	161	26	compared	compare	VBN
cord-002530-ao7kenbx	161	27	to	to	IN
cord-002530-ao7kenbx	161	28	directly	directly	RB
cord-002530-ao7kenbx	161	29	knocking	knock	VBG
cord-002530-ao7kenbx	161	30	down	down	RP
cord-002530-ao7kenbx	161	31	the	the	DT
cord-002530-ao7kenbx	161	32	protein	protein	NN
cord-002530-ao7kenbx	161	33	.	.	.
cord-002530-ao7kenbx	162	1	Next	next	RB
cord-002530-ao7kenbx	162	2	,	,	,
cord-002530-ao7kenbx	162	3	we	-PRON-	PRP
cord-002530-ao7kenbx	162	4	compared	compare	VBD
cord-002530-ao7kenbx	162	5	the	the	DT
cord-002530-ao7kenbx	162	6	antiviral	antiviral	JJ
cord-002530-ao7kenbx	162	7	activity	activity	NN
cord-002530-ao7kenbx	162	8	of	of	IN
cord-002530-ao7kenbx	162	9	NMS-873	nms-873	NN
cord-002530-ao7kenbx	162	10	to	to	IN
cord-002530-ao7kenbx	162	11	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	162	12	,	,	,
cord-002530-ao7kenbx	162	13	currently	currently	RB
cord-002530-ao7kenbx	162	14	the	the	DT
cord-002530-ao7kenbx	162	15	most	most	RBS
cord-002530-ao7kenbx	162	16	commonly	commonly	RB
cord-002530-ao7kenbx	162	17	used	use	VBN
cord-002530-ao7kenbx	162	18	HCMV	HCMV	NNP
cord-002530-ao7kenbx	162	19	antiviral	antiviral	JJ
cord-002530-ao7kenbx	162	20	.	.	.
cord-002530-ao7kenbx	163	1	Primary	primary	JJ
cord-002530-ao7kenbx	163	2	human	human	JJ
cord-002530-ao7kenbx	163	3	fibroblast	fibroblast	NN
cord-002530-ao7kenbx	163	4	cells	cell	NNS
cord-002530-ao7kenbx	163	5	were	be	VBD
cord-002530-ao7kenbx	163	6	pretreated	pretreate	VBN
cord-002530-ao7kenbx	163	7	with	with	IN
cord-002530-ao7kenbx	163	8	different	different	JJ
cord-002530-ao7kenbx	163	9	concentrations	concentration	NNS
cord-002530-ao7kenbx	163	10	of	of	IN
cord-002530-ao7kenbx	163	11	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	163	12	,	,	,
cord-002530-ao7kenbx	163	13	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	163	14	or	or	CC
cord-002530-ao7kenbx	163	15	DMSO	DMSO	NNP
cord-002530-ao7kenbx	163	16	control	control	NN
cord-002530-ao7kenbx	163	17	,	,	,
cord-002530-ao7kenbx	163	18	with	with	IN
cord-002530-ao7kenbx	163	19	cells	cell	NNS
cord-002530-ao7kenbx	163	20	and	and	CC
cord-002530-ao7kenbx	163	21	supernatant	supernatant	VBN
cord-002530-ao7kenbx	163	22	harvested	harvest	VBN
cord-002530-ao7kenbx	163	23	seven	seven	CD
cord-002530-ao7kenbx	163	24	days	day	NNS
cord-002530-ao7kenbx	163	25	post	post	NN
cord-002530-ao7kenbx	163	26	infection	infection	NN
cord-002530-ao7kenbx	163	27	for	for	IN
cord-002530-ao7kenbx	163	28	plaque	plaque	NN
cord-002530-ao7kenbx	163	29	assay	assay	NN
cord-002530-ao7kenbx	163	30	.	.	.
cord-002530-ao7kenbx	164	1	As	as	IN
cord-002530-ao7kenbx	164	2	shown	show	VBN
cord-002530-ao7kenbx	164	3	in	in	IN
cord-002530-ao7kenbx	164	4	Fig	Fig	NNP
cord-002530-ao7kenbx	164	5	10B	10B	NNP
cord-002530-ao7kenbx	164	6	,	,	,
cord-002530-ao7kenbx	164	7	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	164	8	and	and	CC
cord-002530-ao7kenbx	164	9	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	164	10	clearly	clearly	RB
cord-002530-ao7kenbx	164	11	inhibited	inhibit	VBD
cord-002530-ao7kenbx	164	12	the	the	DT
cord-002530-ao7kenbx	164	13	production	production	NN
cord-002530-ao7kenbx	164	14	of	of	IN
cord-002530-ao7kenbx	164	15	infectious	infectious	JJ
cord-002530-ao7kenbx	164	16	virus	virus	NN
cord-002530-ao7kenbx	164	17	.	.	.
cord-002530-ao7kenbx	165	1	However	however	RB
cord-002530-ao7kenbx	165	2	,	,	,
cord-002530-ao7kenbx	165	3	NMS-873	nms-873	PRP
cord-002530-ao7kenbx	165	4	displayed	display	VBD
cord-002530-ao7kenbx	165	5	a	a	DT
cord-002530-ao7kenbx	165	6	higher	high	JJR
cord-002530-ao7kenbx	165	7	level	level	NN
cord-002530-ao7kenbx	165	8	of	of	IN
cord-002530-ao7kenbx	165	9	potency	potency	NN
cord-002530-ao7kenbx	165	10	at	at	IN
cord-002530-ao7kenbx	165	11	ten	ten	RB
cord-002530-ao7kenbx	165	12	-	-	HYPH
cord-002530-ao7kenbx	165	13	fold	fold	VB
cord-002530-ao7kenbx	165	14	lower	low	JJR
cord-002530-ao7kenbx	165	15	concentrations	concentration	NNS
cord-002530-ao7kenbx	165	16	,	,	,
cord-002530-ao7kenbx	165	17	with	with	IN
cord-002530-ao7kenbx	165	18	an	an	DT
cord-002530-ao7kenbx	165	19	IC50	IC50	NNP
cord-002530-ao7kenbx	165	20	of	of	IN
cord-002530-ao7kenbx	165	21	0.13	0.13	CD
cord-002530-ao7kenbx	165	22	μM	μm	CD
cord-002530-ao7kenbx	165	23	compared	compare	VBN
cord-002530-ao7kenbx	165	24	to	to	IN
cord-002530-ao7kenbx	165	25	1.3	1.3	CD
cord-002530-ao7kenbx	165	26	μM	μm	NN
cord-002530-ao7kenbx	165	27	for	for	IN
cord-002530-ao7kenbx	165	28	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	165	29	.	.	.
cord-002530-ao7kenbx	166	1	Co	co	NN
cord-002530-ao7kenbx	166	2	-	-	JJ
cord-002530-ao7kenbx	166	3	treating	treat	VBG
cord-002530-ao7kenbx	166	4	cells	cell	NNS
cord-002530-ao7kenbx	166	5	with	with	IN
cord-002530-ao7kenbx	166	6	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	166	7	at	at	IN
cord-002530-ao7kenbx	166	8	the	the	DT
cord-002530-ao7kenbx	166	9	same	same	JJ
cord-002530-ao7kenbx	166	10	time	time	NN
cord-002530-ao7kenbx	166	11	as	as	IN
cord-002530-ao7kenbx	166	12	infection	infection	NN
cord-002530-ao7kenbx	166	13	also	also	RB
cord-002530-ao7kenbx	166	14	resulted	result	VBD
cord-002530-ao7kenbx	166	15	in	in	IN
cord-002530-ao7kenbx	166	16	reduced	reduce	VBN
cord-002530-ao7kenbx	166	17	IE2	ie2	NN
cord-002530-ao7kenbx	166	18	levels	level	NNS
cord-002530-ao7kenbx	166	19	and	and	CC
cord-002530-ao7kenbx	166	20	a	a	DT
cord-002530-ao7kenbx	166	21	similar	similar	JJ
cord-002530-ao7kenbx	166	22	reduction	reduction	NN
cord-002530-ao7kenbx	166	23	in	in	IN
cord-002530-ao7kenbx	166	24	infectious	infectious	JJ
cord-002530-ao7kenbx	166	25	virus	virus	NN
cord-002530-ao7kenbx	166	26	(	(	-LRB-
cord-002530-ao7kenbx	166	27	Fig	Fig	NNP
cord-002530-ao7kenbx	166	28	10C	10c	CD
cord-002530-ao7kenbx	166	29	and	and	CC
cord-002530-ao7kenbx	166	30	S10A	S10A	NNP
cord-002530-ao7kenbx	166	31	Fig	Fig	NNP
cord-002530-ao7kenbx	166	32	)	)	-RRB-
cord-002530-ao7kenbx	166	33	.	.	.
cord-002530-ao7kenbx	167	1	In	in	IN
cord-002530-ao7kenbx	167	2	contrast	contrast	NN
cord-002530-ao7kenbx	167	3	,	,	,
cord-002530-ao7kenbx	167	4	treating	treat	VBG
cord-002530-ao7kenbx	167	5	cells	cell	NNS
cord-002530-ao7kenbx	167	6	24	24	CD
cord-002530-ao7kenbx	167	7	HPI	HPI	NNP
cord-002530-ao7kenbx	167	8	did	do	VBD
cord-002530-ao7kenbx	167	9	not	not	RB
cord-002530-ao7kenbx	167	10	reduce	reduce	VB
cord-002530-ao7kenbx	167	11	IE2	ie2	JJ
cord-002530-ao7kenbx	167	12	expression	expression	NN
cord-002530-ao7kenbx	167	13	or	or	CC
cord-002530-ao7kenbx	167	14	virus	virus	NN
cord-002530-ao7kenbx	167	15	production	production	NN
cord-002530-ao7kenbx	167	16	to	to	IN
cord-002530-ao7kenbx	167	17	the	the	DT
cord-002530-ao7kenbx	167	18	same	same	JJ
cord-002530-ao7kenbx	167	19	extent	extent	NN
cord-002530-ao7kenbx	167	20	(	(	-LRB-
cord-002530-ao7kenbx	167	21	Fig	Fig	NNP
cord-002530-ao7kenbx	167	22	10C	10c	CD
cord-002530-ao7kenbx	167	23	and	and	CC
cord-002530-ao7kenbx	167	24	S10B	S10B	NNP
cord-002530-ao7kenbx	167	25	 	 	_SP
cord-002530-ao7kenbx	167	26	Fig	Fig	NNP
cord-002530-ao7kenbx	167	27	)	)	-RRB-
cord-002530-ao7kenbx	167	28	.	.	.
cord-002530-ao7kenbx	168	1	While	while	IN
cord-002530-ao7kenbx	168	2	immediate	immediate	JJ
cord-002530-ao7kenbx	168	3	early	early	JJ
cord-002530-ao7kenbx	168	4	and	and	CC
cord-002530-ao7kenbx	168	5	early	early	JJ
cord-002530-ao7kenbx	168	6	viral	viral	JJ
cord-002530-ao7kenbx	168	7	gene	gene	NN
cord-002530-ao7kenbx	168	8	expression	expression	NN
cord-002530-ao7kenbx	168	9	was	be	VBD
cord-002530-ao7kenbx	168	10	not	not	RB
cord-002530-ao7kenbx	168	11	substantially	substantially	RB
cord-002530-ao7kenbx	168	12	affected	affect	VBN
cord-002530-ao7kenbx	168	13	by	by	IN
cord-002530-ao7kenbx	168	14	treatment	treatment	NN
cord-002530-ao7kenbx	168	15	of	of	IN
cord-002530-ao7kenbx	168	16	cells	cell	NNS
cord-002530-ao7kenbx	168	17	with	with	IN
cord-002530-ao7kenbx	168	18	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	168	19	at	at	IN
cord-002530-ao7kenbx	168	20	24	24	CD
cord-002530-ao7kenbx	168	21	hour	hour	NN
cord-002530-ao7kenbx	168	22	post	post	NN
cord-002530-ao7kenbx	168	23	infection	infection	NN
cord-002530-ao7kenbx	168	24	,	,	,
cord-002530-ao7kenbx	168	25	expression	expression	NN
cord-002530-ao7kenbx	168	26	of	of	IN
cord-002530-ao7kenbx	168	27	the	the	DT
cord-002530-ao7kenbx	168	28	late	late	JJ
cord-002530-ao7kenbx	168	29	gene	gene	NN
cord-002530-ao7kenbx	168	30	pp28	pp28	NNP
cord-002530-ao7kenbx	168	31	was	be	VBD
cord-002530-ao7kenbx	168	32	substantially	substantially	RB
cord-002530-ao7kenbx	168	33	reduced	reduce	VBN
cord-002530-ao7kenbx	168	34	,	,	,
cord-002530-ao7kenbx	168	35	with	with	IN
cord-002530-ao7kenbx	168	36	infectious	infectious	JJ
cord-002530-ao7kenbx	168	37	virus	virus	NN
cord-002530-ao7kenbx	168	38	reduced	reduce	VBD
cord-002530-ao7kenbx	168	39	100	100	CD
cord-002530-ao7kenbx	168	40	fold	fold	NN
cord-002530-ao7kenbx	168	41	,	,	,
cord-002530-ao7kenbx	168	42	suggesting	suggest	VBG
cord-002530-ao7kenbx	168	43	VCP	VCP	NNP
cord-002530-ao7kenbx	168	44	may	may	MD
cord-002530-ao7kenbx	168	45	also	also	RB
cord-002530-ao7kenbx	168	46	be	be	VB
cord-002530-ao7kenbx	168	47	involved	involve	VBN
cord-002530-ao7kenbx	168	48	in	in	IN
cord-002530-ao7kenbx	168	49	late	late	JJ
cord-002530-ao7kenbx	168	50	processes	process	NNS
cord-002530-ao7kenbx	168	51	of	of	IN
cord-002530-ao7kenbx	168	52	virus	virus	NN
cord-002530-ao7kenbx	168	53	replication	replication	NN
cord-002530-ao7kenbx	168	54	.	.	.
cord-002530-ao7kenbx	169	1	This	this	DT
cord-002530-ao7kenbx	169	2	is	be	VBZ
cord-002530-ao7kenbx	169	3	consistent	consistent	JJ
cord-002530-ao7kenbx	169	4	with	with	IN
cord-002530-ao7kenbx	169	5	the	the	DT
cord-002530-ao7kenbx	169	6	pleiotropic	pleiotropic	JJ
cord-002530-ao7kenbx	169	7	nature	nature	NN
cord-002530-ao7kenbx	169	8	of	of	IN
cord-002530-ao7kenbx	169	9	VCP	VCP	NNP
cord-002530-ao7kenbx	169	10	and	and	CC
cord-002530-ao7kenbx	169	11	its	-PRON-	PRP$
cord-002530-ao7kenbx	169	12	potential	potential	NN
cord-002530-ao7kenbx	169	13	to	to	TO
cord-002530-ao7kenbx	169	14	affect	affect	VB
cord-002530-ao7kenbx	169	15	HCMV	HCMV	NNP
cord-002530-ao7kenbx	169	16	replication	replication	NN
cord-002530-ao7kenbx	169	17	in	in	IN
cord-002530-ao7kenbx	169	18	a	a	DT
cord-002530-ao7kenbx	169	19	multitude	multitude	NN
cord-002530-ao7kenbx	169	20	of	of	IN
cord-002530-ao7kenbx	169	21	ways	way	NNS
cord-002530-ao7kenbx	169	22	.	.	.
cord-002530-ao7kenbx	170	1	Treatment	treatment	NN
cord-002530-ao7kenbx	170	2	with	with	IN
cord-002530-ao7kenbx	170	3	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	170	4	also	also	RB
cord-002530-ao7kenbx	170	5	showed	show	VBD
cord-002530-ao7kenbx	170	6	little	little	JJ
cord-002530-ao7kenbx	170	7	toxicity	toxicity	NN
cord-002530-ao7kenbx	170	8	at	at	IN
cord-002530-ao7kenbx	170	9	effective	effective	JJ
cord-002530-ao7kenbx	170	10	concentrations	concentration	NNS
cord-002530-ao7kenbx	170	11	(	(	-LRB-
cord-002530-ao7kenbx	170	12	Fig	Fig	NNP
cord-002530-ao7kenbx	170	13	10D	10d	CD
cord-002530-ao7kenbx	170	14	)	)	-RRB-
cord-002530-ao7kenbx	170	15	,	,	,
cord-002530-ao7kenbx	170	16	suggesting	suggest	VBG
cord-002530-ao7kenbx	170	17	NMS-873	nms-873	RB
cord-002530-ao7kenbx	170	18	and	and	CC
cord-002530-ao7kenbx	170	19	small	small	JJ
cord-002530-ao7kenbx	170	20	molecule	molecule	NN
cord-002530-ao7kenbx	170	21	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	170	22	of	of	IN
cord-002530-ao7kenbx	170	23	VCP	VCP	NNP
cord-002530-ao7kenbx	170	24	show	show	VBP
cord-002530-ao7kenbx	170	25	significant	significant	JJ
cord-002530-ao7kenbx	170	26	potential	potential	NN
cord-002530-ao7kenbx	170	27	as	as	IN
cord-002530-ao7kenbx	170	28	HCMV	HCMV	NNP
cord-002530-ao7kenbx	170	29	antiviral	antiviral	JJ
cord-002530-ao7kenbx	170	30	therapies	therapy	NNS
cord-002530-ao7kenbx	170	31	.	.	.
cord-002530-ao7kenbx	171	1	VCP	VCP	NNP
cord-002530-ao7kenbx	171	2	plays	play	VBZ
cord-002530-ao7kenbx	171	3	a	a	DT
cord-002530-ao7kenbx	171	4	pivotal	pivotal	JJ
cord-002530-ao7kenbx	171	5	role	role	NN
cord-002530-ao7kenbx	171	6	in	in	IN
cord-002530-ao7kenbx	171	7	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	171	8	-	-	HYPH
cord-002530-ao7kenbx	171	9	dependent	dependent	JJ
cord-002530-ao7kenbx	171	10	signaling	signal	VBG
cord-002530-ao7kenbx	171	11	through	through	IN
cord-002530-ao7kenbx	171	12	remodeling	remodel	VBG
cord-002530-ao7kenbx	171	13	target	target	NN
cord-002530-ao7kenbx	171	14	proteins	protein	NNS
cord-002530-ao7kenbx	171	15	,	,	,
cord-002530-ao7kenbx	171	16	often	often	RB
cord-002530-ao7kenbx	171	17	leading	lead	VBG
cord-002530-ao7kenbx	171	18	to	to	IN
cord-002530-ao7kenbx	171	19	proteosomal	proteosomal	JJ
cord-002530-ao7kenbx	171	20	degradation	degradation	NN
cord-002530-ao7kenbx	171	21	.	.	.
cord-002530-ao7kenbx	172	1	As	as	IN
cord-002530-ao7kenbx	172	2	such	such	JJ
cord-002530-ao7kenbx	172	3	it	-PRON-	PRP
cord-002530-ao7kenbx	172	4	is	be	VBZ
cord-002530-ao7kenbx	172	5	linked	link	VBN
cord-002530-ao7kenbx	172	6	to	to	IN
cord-002530-ao7kenbx	172	7	a	a	DT
cord-002530-ao7kenbx	172	8	wide	wide	JJ
cord-002530-ao7kenbx	172	9	range	range	NN
cord-002530-ao7kenbx	172	10	of	of	IN
cord-002530-ao7kenbx	172	11	biological	biological	JJ
cord-002530-ao7kenbx	172	12	functions	function	NNS
cord-002530-ao7kenbx	172	13	,	,	,
cord-002530-ao7kenbx	172	14	including	include	VBG
cord-002530-ao7kenbx	172	15	protein	protein	NN
cord-002530-ao7kenbx	172	16	quality	quality	NN
cord-002530-ao7kenbx	172	17	control	control	NN
cord-002530-ao7kenbx	172	18	,	,	,
cord-002530-ao7kenbx	172	19	autophagy	autophagy	NN
cord-002530-ao7kenbx	172	20	,	,	,
cord-002530-ao7kenbx	172	21	chromatin	chromatin	NN
cord-002530-ao7kenbx	172	22	remodeling	remodeling	NN
cord-002530-ao7kenbx	172	23	and	and	CC
cord-002530-ao7kenbx	172	24	more	more	RBR
cord-002530-ao7kenbx	172	25	recently	recently	RB
cord-002530-ao7kenbx	172	26	RNA	RNA	NNP
cord-002530-ao7kenbx	172	27	processing	processing	NN
cord-002530-ao7kenbx	172	28	[	[	-LRB-
cord-002530-ao7kenbx	172	29	21	21	CD
cord-002530-ao7kenbx	172	30	]	]	-RRB-
cord-002530-ao7kenbx	172	31	.	.	.
cord-002530-ao7kenbx	173	1	Following	follow	VBG
cord-002530-ao7kenbx	173	2	systematic	systematic	JJ
cord-002530-ao7kenbx	173	3	screening	screening	NN
cord-002530-ao7kenbx	173	4	of	of	IN
cord-002530-ao7kenbx	173	5	host	host	NN
cord-002530-ao7kenbx	173	6	genes	gene	NNS
cord-002530-ao7kenbx	173	7	involved	involve	VBN
cord-002530-ao7kenbx	173	8	in	in	IN
cord-002530-ao7kenbx	173	9	membrane	membrane	NN
cord-002530-ao7kenbx	173	10	organization	organization	NN
cord-002530-ao7kenbx	173	11	,	,	,
cord-002530-ao7kenbx	173	12	we	-PRON-	PRP
cord-002530-ao7kenbx	173	13	identified	identify	VBD
cord-002530-ao7kenbx	173	14	VCP	VCP	NNP
cord-002530-ao7kenbx	173	15	as	as	IN
cord-002530-ao7kenbx	173	16	a	a	DT
cord-002530-ao7kenbx	173	17	critical	critical	JJ
cord-002530-ao7kenbx	173	18	host	host	NN
cord-002530-ao7kenbx	173	19	factor	factor	NN
cord-002530-ao7kenbx	173	20	for	for	IN
cord-002530-ao7kenbx	173	21	HCMV	HCMV	NNP
cord-002530-ao7kenbx	173	22	replication	replication	NN
cord-002530-ao7kenbx	173	23	.	.	.
cord-002530-ao7kenbx	174	1	Further	further	JJ
cord-002530-ao7kenbx	174	2	characterization	characterization	NN
cord-002530-ao7kenbx	174	3	demonstrated	demonstrate	VBD
cord-002530-ao7kenbx	174	4	that	that	IN
cord-002530-ao7kenbx	174	5	knockdown	knockdown	NN
cord-002530-ao7kenbx	174	6	of	of	IN
cord-002530-ao7kenbx	174	7	VCP	VCP	NNP
cord-002530-ao7kenbx	174	8	resulted	result	VBD
cord-002530-ao7kenbx	174	9	in	in	IN
cord-002530-ao7kenbx	174	10	an	an	DT
cord-002530-ao7kenbx	174	11	initial	initial	JJ
cord-002530-ao7kenbx	174	12	increase	increase	NN
cord-002530-ao7kenbx	174	13	in	in	IN
cord-002530-ao7kenbx	174	14	MIE	MIE	NNP
cord-002530-ao7kenbx	174	15	transcription	transcription	NN
cord-002530-ao7kenbx	174	16	,	,	,
cord-002530-ao7kenbx	174	17	followed	follow	VBN
cord-002530-ao7kenbx	174	18	by	by	IN
cord-002530-ao7kenbx	174	19	a	a	DT
cord-002530-ao7kenbx	174	20	substantial	substantial	JJ
cord-002530-ao7kenbx	174	21	reduction	reduction	NN
cord-002530-ao7kenbx	174	22	in	in	IN
cord-002530-ao7kenbx	174	23	the	the	DT
cord-002530-ao7kenbx	174	24	expression	expression	NN
cord-002530-ao7kenbx	174	25	of	of	IN
cord-002530-ao7kenbx	174	26	the	the	DT
cord-002530-ao7kenbx	174	27	major	major	JJ
cord-002530-ao7kenbx	174	28	immediate	immediate	JJ
cord-002530-ao7kenbx	174	29	early	early	JJ
cord-002530-ao7kenbx	174	30	transcript	transcript	NN
cord-002530-ao7kenbx	174	31	IE2	ie2	NN
cord-002530-ao7kenbx	174	32	.	.	.
cord-002530-ao7kenbx	175	1	Strikingly	strikingly	RB
cord-002530-ao7kenbx	175	2	,	,	,
cord-002530-ao7kenbx	175	3	despite	despite	IN
cord-002530-ao7kenbx	175	4	being	be	VBG
cord-002530-ao7kenbx	175	5	expressed	express	VBN
cord-002530-ao7kenbx	175	6	from	from	IN
cord-002530-ao7kenbx	175	7	the	the	DT
cord-002530-ao7kenbx	175	8	same	same	JJ
cord-002530-ao7kenbx	175	9	primary	primary	JJ
cord-002530-ao7kenbx	175	10	transcript	transcript	NN
cord-002530-ao7kenbx	175	11	,	,	,
cord-002530-ao7kenbx	175	12	IE1	ie1	NN
cord-002530-ao7kenbx	175	13	levels	level	NNS
cord-002530-ao7kenbx	175	14	increased	increase	VBD
cord-002530-ao7kenbx	175	15	following	follow	VBG
cord-002530-ao7kenbx	175	16	VCP	VCP	NNP
cord-002530-ao7kenbx	175	17	knockdown	knockdown	NN
cord-002530-ao7kenbx	175	18	.	.	.
cord-002530-ao7kenbx	176	1	Our	-PRON-	PRP$
cord-002530-ao7kenbx	176	2	data	datum	NNS
cord-002530-ao7kenbx	176	3	also	also	RB
cord-002530-ao7kenbx	176	4	suggests	suggest	VBZ
cord-002530-ao7kenbx	176	5	that	that	IN
cord-002530-ao7kenbx	176	6	VCP	VCP	NNP
cord-002530-ao7kenbx	176	7	plays	play	VBZ
cord-002530-ao7kenbx	176	8	a	a	DT
cord-002530-ao7kenbx	176	9	role	role	NN
cord-002530-ao7kenbx	176	10	during	during	IN
cord-002530-ao7kenbx	176	11	late	late	JJ
cord-002530-ao7kenbx	176	12	stages	stage	NNS
cord-002530-ao7kenbx	176	13	of	of	IN
cord-002530-ao7kenbx	176	14	virus	virus	NN
cord-002530-ao7kenbx	176	15	replication	replication	NN
cord-002530-ao7kenbx	176	16	as	as	IN
cord-002530-ao7kenbx	176	17	inhibition	inhibition	NN
cord-002530-ao7kenbx	176	18	of	of	IN
cord-002530-ao7kenbx	176	19	VCP	VCP	NNP
cord-002530-ao7kenbx	176	20	24	24	CD
cord-002530-ao7kenbx	176	21	HPI	HPI	NNP
cord-002530-ao7kenbx	176	22	did	do	VBD
cord-002530-ao7kenbx	176	23	not	not	RB
cord-002530-ao7kenbx	176	24	substantially	substantially	RB
cord-002530-ao7kenbx	176	25	affect	affect	VB
cord-002530-ao7kenbx	176	26	IE2	ie2	JJ
cord-002530-ao7kenbx	176	27	expression	expression	NN
cord-002530-ao7kenbx	176	28	but	but	CC
cord-002530-ao7kenbx	176	29	still	still	RB
cord-002530-ao7kenbx	176	30	resulted	result	VBD
cord-002530-ao7kenbx	176	31	in	in	IN
cord-002530-ao7kenbx	176	32	a	a	DT
cord-002530-ao7kenbx	176	33	two	two	CD
cord-002530-ao7kenbx	176	34	-	-	HYPH
cord-002530-ao7kenbx	176	35	log	log	NN
cord-002530-ao7kenbx	176	36	reduction	reduction	NN
cord-002530-ao7kenbx	176	37	in	in	IN
cord-002530-ao7kenbx	176	38	infectious	infectious	JJ
cord-002530-ao7kenbx	176	39	virus	virus	NN
cord-002530-ao7kenbx	176	40	.	.	.
cord-002530-ao7kenbx	177	1	Given	give	VBN
cord-002530-ao7kenbx	177	2	the	the	DT
cord-002530-ao7kenbx	177	3	functionally	functionally	RB
cord-002530-ao7kenbx	177	4	pleotropic	pleotropic	JJ
cord-002530-ao7kenbx	177	5	nature	nature	NN
cord-002530-ao7kenbx	177	6	of	of	IN
cord-002530-ao7kenbx	177	7	VCP	VCP	NNP
cord-002530-ao7kenbx	177	8	,	,	,
cord-002530-ao7kenbx	177	9	it	-PRON-	PRP
cord-002530-ao7kenbx	177	10	is	be	VBZ
cord-002530-ao7kenbx	177	11	unsurprising	unsurprising	JJ
cord-002530-ao7kenbx	177	12	that	that	IN
cord-002530-ao7kenbx	177	13	knockdown	knockdown	NN
cord-002530-ao7kenbx	177	14	results	result	NNS
cord-002530-ao7kenbx	177	15	in	in	IN
cord-002530-ao7kenbx	177	16	multifactorial	multifactorial	JJ
cord-002530-ao7kenbx	177	17	effects	effect	NNS
cord-002530-ao7kenbx	177	18	on	on	IN
cord-002530-ao7kenbx	177	19	the	the	DT
cord-002530-ao7kenbx	177	20	virus	virus	NN
cord-002530-ao7kenbx	177	21	and	and	CC
cord-002530-ao7kenbx	177	22	potentially	potentially	RB
cord-002530-ao7kenbx	177	23	reflects	reflect	VBZ
cord-002530-ao7kenbx	177	24	the	the	DT
cord-002530-ao7kenbx	177	25	diverse	diverse	JJ
cord-002530-ao7kenbx	177	26	roles	role	NNS
cord-002530-ao7kenbx	177	27	of	of	IN
cord-002530-ao7kenbx	177	28	ubiquitin	ubiquitin	JJ
cord-002530-ao7kenbx	177	29	modulation	modulation	NN
cord-002530-ao7kenbx	177	30	and	and	CC
cord-002530-ao7kenbx	177	31	signaling	signal	VBG
cord-002530-ao7kenbx	177	32	during	during	IN
cord-002530-ao7kenbx	177	33	virus	virus	NN
cord-002530-ao7kenbx	177	34	infection	infection	NN
cord-002530-ao7kenbx	177	35	.	.	.
cord-002530-ao7kenbx	178	1	Viral	viral	JJ
cord-002530-ao7kenbx	178	2	gene	gene	NN
cord-002530-ao7kenbx	178	3	expression	expression	NN
cord-002530-ao7kenbx	178	4	during	during	IN
cord-002530-ao7kenbx	178	5	HCMV	HCMV	NNP
cord-002530-ao7kenbx	178	6	replication	replication	NN
cord-002530-ao7kenbx	178	7	occurs	occur	VBZ
cord-002530-ao7kenbx	178	8	through	through	IN
cord-002530-ao7kenbx	178	9	a	a	DT
cord-002530-ao7kenbx	178	10	tightly	tightly	RB
cord-002530-ao7kenbx	178	11	regulated	regulate	VBN
cord-002530-ao7kenbx	178	12	cascade	cascade	NN
cord-002530-ao7kenbx	178	13	mechanism	mechanism	NN
cord-002530-ao7kenbx	178	14	with	with	IN
cord-002530-ao7kenbx	178	15	expression	expression	NN
cord-002530-ao7kenbx	178	16	of	of	IN
cord-002530-ao7kenbx	178	17	the	the	DT
cord-002530-ao7kenbx	178	18	MIE	MIE	NNP
cord-002530-ao7kenbx	178	19	genes	gene	NNS
cord-002530-ao7kenbx	178	20	IE1	IE1	NNP
cord-002530-ao7kenbx	178	21	and	and	CC
cord-002530-ao7kenbx	178	22	,	,	,
cord-002530-ao7kenbx	178	23	in	in	IN
cord-002530-ao7kenbx	178	24	particular	particular	JJ
cord-002530-ao7kenbx	178	25	,	,	,
cord-002530-ao7kenbx	178	26	IE2	ie2	JJ
cord-002530-ao7kenbx	178	27	,	,	,
cord-002530-ao7kenbx	178	28	required	require	VBN
cord-002530-ao7kenbx	178	29	for	for	IN
cord-002530-ao7kenbx	178	30	transactivation	transactivation	NN
cord-002530-ao7kenbx	178	31	of	of	IN
cord-002530-ao7kenbx	178	32	early	early	JJ
cord-002530-ao7kenbx	178	33	viral	viral	JJ
cord-002530-ao7kenbx	178	34	genes	gene	NNS
cord-002530-ao7kenbx	178	35	and	and	CC
cord-002530-ao7kenbx	178	36	subsequent	subsequent	JJ
cord-002530-ao7kenbx	178	37	late	late	JJ
cord-002530-ao7kenbx	178	38	viral	viral	JJ
cord-002530-ao7kenbx	178	39	gene	gene	NN
cord-002530-ao7kenbx	178	40	expression	expression	NN
cord-002530-ao7kenbx	178	41	.	.	.
cord-002530-ao7kenbx	179	1	Due	due	IN
cord-002530-ao7kenbx	179	2	to	to	IN
cord-002530-ao7kenbx	179	3	the	the	DT
cord-002530-ao7kenbx	179	4	central	central	JJ
cord-002530-ao7kenbx	179	5	role	role	NN
cord-002530-ao7kenbx	179	6	of	of	IN
cord-002530-ao7kenbx	179	7	the	the	DT
cord-002530-ao7kenbx	179	8	MIE	MIE	NNP
cord-002530-ao7kenbx	179	9	proteins	protein	NNS
cord-002530-ao7kenbx	179	10	in	in	IN
cord-002530-ao7kenbx	179	11	driving	drive	VBG
cord-002530-ao7kenbx	179	12	replication	replication	NN
cord-002530-ao7kenbx	179	13	of	of	IN
cord-002530-ao7kenbx	179	14	the	the	DT
cord-002530-ao7kenbx	179	15	virus	virus	NN
cord-002530-ao7kenbx	179	16	they	-PRON-	PRP
cord-002530-ao7kenbx	179	17	have	have	VBP
cord-002530-ao7kenbx	179	18	been	be	VBN
cord-002530-ao7kenbx	179	19	suggested	suggest	VBN
cord-002530-ao7kenbx	179	20	to	to	TO
cord-002530-ao7kenbx	179	21	play	play	VB
cord-002530-ao7kenbx	179	22	a	a	DT
cord-002530-ao7kenbx	179	23	pivotal	pivotal	JJ
cord-002530-ao7kenbx	179	24	role	role	NN
cord-002530-ao7kenbx	179	25	in	in	IN
cord-002530-ao7kenbx	179	26	regulating	regulate	VBG
cord-002530-ao7kenbx	179	27	the	the	DT
cord-002530-ao7kenbx	179	28	balance	balance	NN
cord-002530-ao7kenbx	179	29	between	between	IN
cord-002530-ao7kenbx	179	30	productive	productive	JJ
cord-002530-ao7kenbx	179	31	and	and	CC
cord-002530-ao7kenbx	179	32	latent	latent	JJ
cord-002530-ao7kenbx	179	33	infection	infection	NN
cord-002530-ao7kenbx	179	34	.	.	.
cord-002530-ao7kenbx	180	1	IE1	ie1	NN
cord-002530-ao7kenbx	180	2	and	and	CC
cord-002530-ao7kenbx	180	3	IE2	IE2	NNP
cord-002530-ao7kenbx	180	4	are	be	VBP
cord-002530-ao7kenbx	180	5	generated	generate	VBN
cord-002530-ao7kenbx	180	6	from	from	IN
cord-002530-ao7kenbx	180	7	the	the	DT
cord-002530-ao7kenbx	180	8	same	same	JJ
cord-002530-ao7kenbx	180	9	primary	primary	JJ
cord-002530-ao7kenbx	180	10	transcript	transcript	NN
cord-002530-ao7kenbx	180	11	by	by	IN
cord-002530-ao7kenbx	180	12	alternative	alternative	JJ
cord-002530-ao7kenbx	180	13	splicing	splicing	NN
cord-002530-ao7kenbx	180	14	,	,	,
cord-002530-ao7kenbx	180	15	sharing	share	VBG
cord-002530-ao7kenbx	180	16	the	the	DT
cord-002530-ao7kenbx	180	17	first	first	JJ
cord-002530-ao7kenbx	180	18	three	three	CD
cord-002530-ao7kenbx	180	19	exons	exon	NNS
cord-002530-ao7kenbx	180	20	,	,	,
cord-002530-ao7kenbx	180	21	while	while	IN
cord-002530-ao7kenbx	180	22	splicing	splice	VBG
cord-002530-ao7kenbx	180	23	to	to	IN
cord-002530-ao7kenbx	180	24	independent	independent	JJ
cord-002530-ao7kenbx	180	25	final	final	JJ
cord-002530-ao7kenbx	180	26	exons	exon	NNS
cord-002530-ao7kenbx	180	27	through	through	IN
cord-002530-ao7kenbx	180	28	the	the	DT
cord-002530-ao7kenbx	180	29	relatively	relatively	RB
cord-002530-ao7kenbx	180	30	unusual	unusual	JJ
cord-002530-ao7kenbx	180	31	process	process	NN
cord-002530-ao7kenbx	180	32	of	of	IN
cord-002530-ao7kenbx	180	33	terminal	terminal	NN
cord-002530-ao7kenbx	180	34	exon	exon	NN
cord-002530-ao7kenbx	180	35	skipping	skip	VBG
cord-002530-ao7kenbx	180	36	[	[	-LRB-
cord-002530-ao7kenbx	180	37	10	10	CD
cord-002530-ao7kenbx	180	38	,	,	,
cord-002530-ao7kenbx	180	39	12	12	CD
cord-002530-ao7kenbx	180	40	]	]	-RRB-
cord-002530-ao7kenbx	180	41	.	.	.
cord-002530-ao7kenbx	181	1	Consistent	consistent	JJ
cord-002530-ao7kenbx	181	2	with	with	IN
cord-002530-ao7kenbx	181	3	previous	previous	JJ
cord-002530-ao7kenbx	181	4	publications	publication	NNS
cord-002530-ao7kenbx	181	5	[	[	-LRB-
cord-002530-ao7kenbx	181	6	33	33	CD
cord-002530-ao7kenbx	181	7	,	,	,
cord-002530-ao7kenbx	181	8	34	34	CD
cord-002530-ao7kenbx	181	9	]	]	-RRB-
cord-002530-ao7kenbx	181	10	,	,	,
cord-002530-ao7kenbx	181	11	our	-PRON-	PRP$
cord-002530-ao7kenbx	181	12	data	datum	NNS
cord-002530-ao7kenbx	181	13	shows	show	VBZ
cord-002530-ao7kenbx	181	14	that	that	IN
cord-002530-ao7kenbx	181	15	IE1	ie1	NN
cord-002530-ao7kenbx	181	16	expression	expression	NN
cord-002530-ao7kenbx	181	17	levels	level	NNS
cord-002530-ao7kenbx	181	18	increase	increase	VBP
cord-002530-ao7kenbx	181	19	more	more	RBR
cord-002530-ao7kenbx	181	20	rapidly	rapidly	RB
cord-002530-ao7kenbx	181	21	than	than	IN
cord-002530-ao7kenbx	181	22	IE2	ie2	NN
cord-002530-ao7kenbx	181	23	,	,	,
cord-002530-ao7kenbx	181	24	due	due	IN
cord-002530-ao7kenbx	181	25	to	to	IN
cord-002530-ao7kenbx	181	26	preferential	preferential	JJ
cord-002530-ao7kenbx	181	27	splicing	splicing	NN
cord-002530-ao7kenbx	181	28	to	to	IN
cord-002530-ao7kenbx	181	29	the	the	DT
cord-002530-ao7kenbx	181	30	IE1	IE1	NNP
cord-002530-ao7kenbx	181	31	terminal	terminal	NN
cord-002530-ao7kenbx	181	32	exon	exon	NN
cord-002530-ao7kenbx	181	33	4	4	CD
cord-002530-ao7kenbx	181	34	,	,	,
cord-002530-ao7kenbx	181	35	resulting	result	VBG
cord-002530-ao7kenbx	181	36	in	in	IN
cord-002530-ao7kenbx	181	37	lower	low	JJR
cord-002530-ao7kenbx	181	38	levels	level	NNS
cord-002530-ao7kenbx	181	39	of	of	IN
cord-002530-ao7kenbx	181	40	IE2	ie2	NN
cord-002530-ao7kenbx	181	41	transcription	transcription	NN
cord-002530-ao7kenbx	181	42	,	,	,
cord-002530-ao7kenbx	181	43	which	which	WDT
cord-002530-ao7kenbx	181	44	plateaus	plateaus	VBP
cord-002530-ao7kenbx	181	45	between	between	IN
cord-002530-ao7kenbx	181	46	12	12	CD
cord-002530-ao7kenbx	181	47	and	and	CC
cord-002530-ao7kenbx	181	48	24	24	CD
cord-002530-ao7kenbx	181	49	HPI	HPI	NNP
cord-002530-ao7kenbx	181	50	(	(	-LRB-
cord-002530-ao7kenbx	181	51	S2	s2	NN
cord-002530-ao7kenbx	181	52	,	,	,
cord-002530-ao7kenbx	181	53	S3	S3	NNP
cord-002530-ao7kenbx	181	54	and	and	CC
cord-002530-ao7kenbx	181	55	S4	S4	NNP
cord-002530-ao7kenbx	181	56	Figs	Figs	NNP
cord-002530-ao7kenbx	181	57	)	)	-RRB-
cord-002530-ao7kenbx	181	58	.	.	.
cord-002530-ao7kenbx	182	1	As	as	IN
cord-002530-ao7kenbx	182	2	infection	infection	NN
cord-002530-ao7kenbx	182	3	progresses	progress	VBZ
cord-002530-ao7kenbx	182	4	,	,	,
cord-002530-ao7kenbx	182	5	splicing	splice	VBG
cord-002530-ao7kenbx	182	6	to	to	IN
cord-002530-ao7kenbx	182	7	IE2	ie2	NN
cord-002530-ao7kenbx	182	8	terminal	terminal	NN
cord-002530-ao7kenbx	182	9	exon	exon	NN
cord-002530-ao7kenbx	182	10	5	5	CD
cord-002530-ao7kenbx	182	11	increases	increase	NNS
cord-002530-ao7kenbx	182	12	,	,	,
cord-002530-ao7kenbx	182	13	with	with	IN
cord-002530-ao7kenbx	182	14	a	a	DT
cord-002530-ao7kenbx	182	15	corresponding	corresponding	JJ
cord-002530-ao7kenbx	182	16	decrease	decrease	NN
cord-002530-ao7kenbx	182	17	in	in	IN
cord-002530-ao7kenbx	182	18	IE1	ie1	NN
cord-002530-ao7kenbx	182	19	splicing	splicing	NN
cord-002530-ao7kenbx	182	20	.	.	.
cord-002530-ao7kenbx	183	1	Regulation	regulation	NN
cord-002530-ao7kenbx	183	2	of	of	IN
cord-002530-ao7kenbx	183	3	alternative	alternative	JJ
cord-002530-ao7kenbx	183	4	splicing	splicing	NN
cord-002530-ao7kenbx	183	5	of	of	IN
cord-002530-ao7kenbx	183	6	the	the	DT
cord-002530-ao7kenbx	183	7	MIE	MIE	NNP
cord-002530-ao7kenbx	183	8	transcripts	transcript	NNS
cord-002530-ao7kenbx	183	9	is	be	VBZ
cord-002530-ao7kenbx	183	10	therefore	therefore	RB
cord-002530-ao7kenbx	183	11	crucial	crucial	JJ
cord-002530-ao7kenbx	183	12	for	for	IN
cord-002530-ao7kenbx	183	13	determining	determine	VBG
cord-002530-ao7kenbx	183	14	whether	whether	IN
cord-002530-ao7kenbx	183	15	replication	replication	NN
cord-002530-ao7kenbx	183	16	of	of	IN
cord-002530-ao7kenbx	183	17	the	the	DT
cord-002530-ao7kenbx	183	18	virus	virus	NN
cord-002530-ao7kenbx	183	19	progresses	progress	VBZ
cord-002530-ao7kenbx	183	20	,	,	,
cord-002530-ao7kenbx	183	21	as	as	IN
cord-002530-ao7kenbx	183	22	expression	expression	NN
cord-002530-ao7kenbx	183	23	of	of	IN
cord-002530-ao7kenbx	183	24	IE2	ie2	NN
cord-002530-ao7kenbx	183	25	is	be	VBZ
cord-002530-ao7kenbx	183	26	dependent	dependent	JJ
cord-002530-ao7kenbx	183	27	on	on	IN
cord-002530-ao7kenbx	183	28	this	this	DT
cord-002530-ao7kenbx	183	29	switch	switch	NN
cord-002530-ao7kenbx	183	30	in	in	IN
cord-002530-ao7kenbx	183	31	splicing	splicing	NN
cord-002530-ao7kenbx	183	32	.	.	.
cord-002530-ao7kenbx	184	1	Although	although	IN
cord-002530-ao7kenbx	184	2	the	the	DT
cord-002530-ao7kenbx	184	3	timing	timing	NN
cord-002530-ao7kenbx	184	4	and	and	CC
cord-002530-ao7kenbx	184	5	precise	precise	JJ
cord-002530-ao7kenbx	184	6	splicing	splicing	NN
cord-002530-ao7kenbx	184	7	pattern	pattern	NN
cord-002530-ao7kenbx	184	8	of	of	IN
cord-002530-ao7kenbx	184	9	the	the	DT
cord-002530-ao7kenbx	184	10	MIE	MIE	NNP
cord-002530-ao7kenbx	184	11	region	region	NN
cord-002530-ao7kenbx	184	12	has	have	VBZ
cord-002530-ao7kenbx	184	13	been	be	VBN
cord-002530-ao7kenbx	184	14	well	well	RB
cord-002530-ao7kenbx	184	15	documented	document	VBN
cord-002530-ao7kenbx	184	16	,	,	,
cord-002530-ao7kenbx	184	17	how	how	WRB
cord-002530-ao7kenbx	184	18	the	the	DT
cord-002530-ao7kenbx	184	19	splicing	splicing	NN
cord-002530-ao7kenbx	184	20	is	be	VBZ
cord-002530-ao7kenbx	184	21	regulated	regulate	VBN
cord-002530-ao7kenbx	184	22	and	and	CC
cord-002530-ao7kenbx	184	23	the	the	DT
cord-002530-ao7kenbx	184	24	downstream	downstream	JJ
cord-002530-ao7kenbx	184	25	consequences	consequence	NNS
cord-002530-ao7kenbx	184	26	for	for	IN
cord-002530-ao7kenbx	184	27	virus	virus	NN
cord-002530-ao7kenbx	184	28	replication	replication	NN
cord-002530-ao7kenbx	184	29	are	be	VBP
cord-002530-ao7kenbx	184	30	poorly	poorly	RB
cord-002530-ao7kenbx	184	31	understood	understand	VBN
cord-002530-ao7kenbx	184	32	[	[	-LRB-
cord-002530-ao7kenbx	184	33	10	10	CD
cord-002530-ao7kenbx	184	34	]	]	-RRB-
cord-002530-ao7kenbx	184	35	.	.	.
cord-002530-ao7kenbx	185	1	However	however	RB
cord-002530-ao7kenbx	185	2	,	,	,
cord-002530-ao7kenbx	185	3	it	-PRON-	PRP
cord-002530-ao7kenbx	185	4	is	be	VBZ
cord-002530-ao7kenbx	185	5	likely	likely	JJ
cord-002530-ao7kenbx	185	6	to	to	TO
cord-002530-ao7kenbx	185	7	depend	depend	VB
cord-002530-ao7kenbx	185	8	on	on	IN
cord-002530-ao7kenbx	185	9	a	a	DT
cord-002530-ao7kenbx	185	10	complex	complex	JJ
cord-002530-ao7kenbx	185	11	interplay	interplay	NN
cord-002530-ao7kenbx	185	12	of	of	IN
cord-002530-ao7kenbx	185	13	cellular	cellular	JJ
cord-002530-ao7kenbx	185	14	and	and	CC
cord-002530-ao7kenbx	185	15	viral	viral	JJ
cord-002530-ao7kenbx	185	16	factors	factor	NNS
cord-002530-ao7kenbx	185	17	and	and	CC
cord-002530-ao7kenbx	185	18	the	the	DT
cord-002530-ao7kenbx	185	19	architecture	architecture	NN
cord-002530-ao7kenbx	185	20	of	of	IN
cord-002530-ao7kenbx	185	21	the	the	DT
cord-002530-ao7kenbx	185	22	MIE	MIE	NNP
cord-002530-ao7kenbx	185	23	transcriptional	transcriptional	JJ
cord-002530-ao7kenbx	185	24	region	region	NN
cord-002530-ao7kenbx	185	25	[	[	-LRB-
cord-002530-ao7kenbx	185	26	37	37	CD
cord-002530-ao7kenbx	185	27	]	]	-RRB-
cord-002530-ao7kenbx	185	28	.	.	.
cord-002530-ao7kenbx	186	1	Expression	expression	NN
cord-002530-ao7kenbx	186	2	of	of	IN
cord-002530-ao7kenbx	186	3	the	the	DT
cord-002530-ao7kenbx	186	4	MIE	MIE	NNP
cord-002530-ao7kenbx	186	5	transcripts	transcript	NNS
cord-002530-ao7kenbx	186	6	and	and	CC
cord-002530-ao7kenbx	186	7	their	-PRON-	PRP$
cord-002530-ao7kenbx	186	8	splicing	splicing	NN
cord-002530-ao7kenbx	186	9	are	be	VBP
cord-002530-ao7kenbx	186	10	intimately	intimately	RB
cord-002530-ao7kenbx	186	11	linked	link	VBN
cord-002530-ao7kenbx	186	12	to	to	IN
cord-002530-ao7kenbx	186	13	multiple	multiple	JJ
cord-002530-ao7kenbx	186	14	factors	factor	NNS
cord-002530-ao7kenbx	186	15	including	include	VBG
cord-002530-ao7kenbx	186	16	cell	cell	NN
cord-002530-ao7kenbx	186	17	cycle	cycle	NN
cord-002530-ao7kenbx	186	18	,	,	,
cord-002530-ao7kenbx	186	19	cell	cell	NN
cord-002530-ao7kenbx	186	20	type	type	NN
cord-002530-ao7kenbx	186	21	and	and	CC
cord-002530-ao7kenbx	186	22	differentiation	differentiation	NN
cord-002530-ao7kenbx	186	23	status	status	NN
cord-002530-ao7kenbx	186	24	[	[	-LRB-
cord-002530-ao7kenbx	186	25	13	13	CD
cord-002530-ao7kenbx	186	26	,	,	,
cord-002530-ao7kenbx	186	27	38	38	CD
cord-002530-ao7kenbx	186	28	,	,	,
cord-002530-ao7kenbx	186	29	39	39	CD
cord-002530-ao7kenbx	186	30	]	]	-RRB-
cord-002530-ao7kenbx	186	31	.	.	.
cord-002530-ao7kenbx	187	1	Suppression	suppression	NN
cord-002530-ao7kenbx	187	2	of	of	IN
cord-002530-ao7kenbx	187	3	MIE	MIE	NNP
cord-002530-ao7kenbx	187	4	transcripts	transcript	NNS
cord-002530-ao7kenbx	187	5	during	during	IN
cord-002530-ao7kenbx	187	6	HCMV	HCMV	NNP
cord-002530-ao7kenbx	187	7	infection	infection	NN
cord-002530-ao7kenbx	187	8	of	of	IN
cord-002530-ao7kenbx	187	9	myeloid	myeloid	JJ
cord-002530-ao7kenbx	187	10	cultures	culture	NNS
cord-002530-ao7kenbx	187	11	is	be	VBZ
cord-002530-ao7kenbx	187	12	thought	think	VBN
cord-002530-ao7kenbx	187	13	to	to	TO
cord-002530-ao7kenbx	187	14	be	be	VB
cord-002530-ao7kenbx	187	15	key	key	JJ
cord-002530-ao7kenbx	187	16	for	for	IN
cord-002530-ao7kenbx	187	17	establishing	establish	VBG
cord-002530-ao7kenbx	187	18	latent	latent	JJ
cord-002530-ao7kenbx	187	19	infection	infection	NN
cord-002530-ao7kenbx	187	20	.	.	.
cord-002530-ao7kenbx	188	1	Conversely	conversely	RB
cord-002530-ao7kenbx	188	2	,	,	,
cord-002530-ao7kenbx	188	3	activation	activation	NN
cord-002530-ao7kenbx	188	4	and	and	CC
cord-002530-ao7kenbx	188	5	differentiation	differentiation	NN
cord-002530-ao7kenbx	188	6	of	of	IN
cord-002530-ao7kenbx	188	7	latently	latently	RB
cord-002530-ao7kenbx	188	8	infected	infect	VBN
cord-002530-ao7kenbx	188	9	cells	cell	NNS
cord-002530-ao7kenbx	188	10	results	result	NNS
cord-002530-ao7kenbx	188	11	in	in	IN
cord-002530-ao7kenbx	188	12	up	up	IN
cord-002530-ao7kenbx	188	13	-	-	HYPH
cord-002530-ao7kenbx	188	14	regulation	regulation	NN
cord-002530-ao7kenbx	188	15	of	of	IN
cord-002530-ao7kenbx	188	16	MIE	MIE	NNP
cord-002530-ao7kenbx	188	17	gene	gene	NN
cord-002530-ao7kenbx	188	18	expression	expression	NN
cord-002530-ao7kenbx	188	19	and	and	CC
cord-002530-ao7kenbx	188	20	subsequent	subsequent	JJ
cord-002530-ao7kenbx	188	21	reactivation	reactivation	NN
cord-002530-ao7kenbx	188	22	.	.	.
cord-002530-ao7kenbx	189	1	During	during	IN
cord-002530-ao7kenbx	189	2	infection	infection	NN
cord-002530-ao7kenbx	189	3	of	of	IN
cord-002530-ao7kenbx	189	4	fibroblast	fibroblast	NN
cord-002530-ao7kenbx	189	5	cells	cell	NNS
cord-002530-ao7kenbx	189	6	,	,	,
cord-002530-ao7kenbx	189	7	expression	expression	NN
cord-002530-ao7kenbx	189	8	of	of	IN
cord-002530-ao7kenbx	189	9	MIE	MIE	NNP
cord-002530-ao7kenbx	189	10	transcripts	transcript	NNS
cord-002530-ao7kenbx	189	11	and	and	CC
cord-002530-ao7kenbx	189	12	replication	replication	NN
cord-002530-ao7kenbx	189	13	are	be	VBP
cord-002530-ao7kenbx	189	14	closely	closely	RB
cord-002530-ao7kenbx	189	15	linked	link	VBN
cord-002530-ao7kenbx	189	16	to	to	IN
cord-002530-ao7kenbx	189	17	cell	cell	NN
cord-002530-ao7kenbx	189	18	cycle	cycle	NN
cord-002530-ao7kenbx	189	19	status	status	NN
cord-002530-ao7kenbx	189	20	,	,	,
cord-002530-ao7kenbx	189	21	with	with	IN
cord-002530-ao7kenbx	189	22	MIE	MIE	NNP
cord-002530-ao7kenbx	189	23	expression	expression	NN
cord-002530-ao7kenbx	189	24	suppressed	suppress	VBN
cord-002530-ao7kenbx	189	25	during	during	IN
cord-002530-ao7kenbx	189	26	S	S	NNP
cord-002530-ao7kenbx	189	27	/	/	SYM
cord-002530-ao7kenbx	189	28	G2	G2	NNP
cord-002530-ao7kenbx	189	29	phase	phase	NN
cord-002530-ao7kenbx	189	30	[	[	-LRB-
cord-002530-ao7kenbx	189	31	40	40	CD
cord-002530-ao7kenbx	189	32	,	,	,
cord-002530-ao7kenbx	189	33	41	41	CD
cord-002530-ao7kenbx	189	34	]	]	-RRB-
cord-002530-ao7kenbx	189	35	.	.	.
cord-002530-ao7kenbx	190	1	This	this	DT
cord-002530-ao7kenbx	190	2	suppression	suppression	NN
cord-002530-ao7kenbx	190	3	is	be	VBZ
cord-002530-ao7kenbx	190	4	due	due	JJ
cord-002530-ao7kenbx	190	5	in	in	IN
cord-002530-ao7kenbx	190	6	part	part	NN
cord-002530-ao7kenbx	190	7	to	to	IN
cord-002530-ao7kenbx	190	8	cyclin	cyclin	VB
cord-002530-ao7kenbx	190	9	A2	A2	NNP
cord-002530-ao7kenbx	190	10	,	,	,
cord-002530-ao7kenbx	190	11	which	which	WDT
cord-002530-ao7kenbx	190	12	alters	alter	VBZ
cord-002530-ao7kenbx	190	13	splicing	splicing	NN
cord-002530-ao7kenbx	190	14	of	of	IN
cord-002530-ao7kenbx	190	15	the	the	DT
cord-002530-ao7kenbx	190	16	MIE	MIE	NNP
cord-002530-ao7kenbx	190	17	transcripts	transcript	NNS
cord-002530-ao7kenbx	190	18	in	in	IN
cord-002530-ao7kenbx	190	19	a	a	DT
cord-002530-ao7kenbx	190	20	manner	manner	NN
cord-002530-ao7kenbx	190	21	similar	similar	JJ
cord-002530-ao7kenbx	190	22	to	to	IN
cord-002530-ao7kenbx	190	23	knockdown	knockdown	NN
cord-002530-ao7kenbx	190	24	of	of	IN
cord-002530-ao7kenbx	190	25	VCP	VCP	NNP
cord-002530-ao7kenbx	190	26	,	,	,
cord-002530-ao7kenbx	190	27	resulting	result	VBG
cord-002530-ao7kenbx	190	28	in	in	IN
cord-002530-ao7kenbx	190	29	loss	loss	NN
cord-002530-ao7kenbx	190	30	of	of	IN
cord-002530-ao7kenbx	190	31	IE2	ie2	JJ
cord-002530-ao7kenbx	190	32	expression	expression	NN
cord-002530-ao7kenbx	190	33	and	and	CC
cord-002530-ao7kenbx	190	34	failure	failure	NN
cord-002530-ao7kenbx	190	35	in	in	IN
cord-002530-ao7kenbx	190	36	virus	virus	NN
cord-002530-ao7kenbx	190	37	replication	replication	NN
cord-002530-ao7kenbx	190	38	[	[	-LRB-
cord-002530-ao7kenbx	190	39	33	33	CD
cord-002530-ao7kenbx	190	40	]	]	-RRB-
cord-002530-ao7kenbx	190	41	.	.	.
cord-002530-ao7kenbx	191	1	While	while	IN
cord-002530-ao7kenbx	191	2	expression	expression	NN
cord-002530-ao7kenbx	191	3	of	of	IN
cord-002530-ao7kenbx	191	4	cyclin	cyclin	NN
cord-002530-ao7kenbx	191	5	A2	A2	NNP
cord-002530-ao7kenbx	191	6	results	result	NNS
cord-002530-ao7kenbx	191	7	in	in	IN
cord-002530-ao7kenbx	191	8	a	a	DT
cord-002530-ao7kenbx	191	9	similar	similar	JJ
cord-002530-ao7kenbx	191	10	phenotype	phenotype	NN
cord-002530-ao7kenbx	191	11	,	,	,
cord-002530-ao7kenbx	191	12	our	-PRON-	PRP$
cord-002530-ao7kenbx	191	13	data	datum	NNS
cord-002530-ao7kenbx	191	14	shows	show	VBZ
cord-002530-ao7kenbx	191	15	that	that	IN
cord-002530-ao7kenbx	191	16	VCP	VCP	NNP
cord-002530-ao7kenbx	191	17	knockdown	knockdown	NN
cord-002530-ao7kenbx	191	18	does	do	VBZ
cord-002530-ao7kenbx	191	19	not	not	RB
cord-002530-ao7kenbx	191	20	cause	cause	VB
cord-002530-ao7kenbx	191	21	gross	gross	JJ
cord-002530-ao7kenbx	191	22	changes	change	NNS
cord-002530-ao7kenbx	191	23	in	in	IN
cord-002530-ao7kenbx	191	24	the	the	DT
cord-002530-ao7kenbx	191	25	cell	cell	NN
cord-002530-ao7kenbx	191	26	cycle	cycle	NN
cord-002530-ao7kenbx	191	27	or	or	CC
cord-002530-ao7kenbx	191	28	increased	increase	VBN
cord-002530-ao7kenbx	191	29	cyclin	cyclin	NN
cord-002530-ao7kenbx	191	30	A2	A2	NNP
cord-002530-ao7kenbx	191	31	expression	expression	NN
cord-002530-ao7kenbx	191	32	,	,	,
cord-002530-ao7kenbx	191	33	indicating	indicate	VBG
cord-002530-ao7kenbx	191	34	an	an	DT
cord-002530-ao7kenbx	191	35	alternative	alternative	JJ
cord-002530-ao7kenbx	191	36	mechanism	mechanism	NN
cord-002530-ao7kenbx	191	37	of	of	IN
cord-002530-ao7kenbx	191	38	action	action	NN
cord-002530-ao7kenbx	191	39	.	.	.
cord-002530-ao7kenbx	192	1	Although	although	IN
cord-002530-ao7kenbx	192	2	the	the	DT
cord-002530-ao7kenbx	192	3	majority	majority	NN
cord-002530-ao7kenbx	192	4	of	of	IN
cord-002530-ao7kenbx	192	5	research	research	NN
cord-002530-ao7kenbx	192	6	on	on	IN
cord-002530-ao7kenbx	192	7	VCP	VCP	NNP
cord-002530-ao7kenbx	192	8	has	have	VBZ
cord-002530-ao7kenbx	192	9	focused	focus	VBN
cord-002530-ao7kenbx	192	10	on	on	IN
cord-002530-ao7kenbx	192	11	its	-PRON-	PRP$
cord-002530-ao7kenbx	192	12	cytoplasmic	cytoplasmic	JJ
cord-002530-ao7kenbx	192	13	activity	activity	NN
cord-002530-ao7kenbx	192	14	,	,	,
cord-002530-ao7kenbx	192	15	recent	recent	JJ
cord-002530-ao7kenbx	192	16	studies	study	NNS
cord-002530-ao7kenbx	192	17	have	have	VBP
cord-002530-ao7kenbx	192	18	identified	identify	VBN
cord-002530-ao7kenbx	192	19	equally	equally	RB
cord-002530-ao7kenbx	192	20	important	important	JJ
cord-002530-ao7kenbx	192	21	and	and	CC
cord-002530-ao7kenbx	192	22	diverse	diverse	JJ
cord-002530-ao7kenbx	192	23	roles	role	NNS
cord-002530-ao7kenbx	192	24	for	for	IN
cord-002530-ao7kenbx	192	25	VCP	VCP	NNP
cord-002530-ao7kenbx	192	26	in	in	IN
cord-002530-ao7kenbx	192	27	the	the	DT
cord-002530-ao7kenbx	192	28	nucleus	nucleus	NN
cord-002530-ao7kenbx	192	29	.	.	.
cord-002530-ao7kenbx	193	1	The	the	DT
cord-002530-ao7kenbx	193	2	association	association	NN
cord-002530-ao7kenbx	193	3	of	of	IN
cord-002530-ao7kenbx	193	4	VCP	VCP	NNP
cord-002530-ao7kenbx	193	5	with	with	IN
cord-002530-ao7kenbx	193	6	the	the	DT
cord-002530-ao7kenbx	193	7	viral	viral	JJ
cord-002530-ao7kenbx	193	8	replication	replication	NN
cord-002530-ao7kenbx	193	9	compartments	compartment	NNS
cord-002530-ao7kenbx	193	10	early	early	RB
cord-002530-ao7kenbx	193	11	in	in	IN
cord-002530-ao7kenbx	193	12	infection	infection	NN
cord-002530-ao7kenbx	193	13	suggests	suggest	VBZ
cord-002530-ao7kenbx	193	14	that	that	IN
cord-002530-ao7kenbx	193	15	the	the	DT
cord-002530-ao7kenbx	193	16	nuclear	nuclear	JJ
cord-002530-ao7kenbx	193	17	functions	function	NNS
cord-002530-ao7kenbx	193	18	of	of	IN
cord-002530-ao7kenbx	193	19	VCP	VCP	NNP
cord-002530-ao7kenbx	193	20	may	may	MD
cord-002530-ao7kenbx	193	21	be	be	VB
cord-002530-ao7kenbx	193	22	playing	play	VBG
cord-002530-ao7kenbx	193	23	a	a	DT
cord-002530-ao7kenbx	193	24	critical	critical	JJ
cord-002530-ao7kenbx	193	25	role	role	NN
cord-002530-ao7kenbx	193	26	in	in	IN
cord-002530-ao7kenbx	193	27	HCMV	HCMV	NNP
cord-002530-ao7kenbx	193	28	replication	replication	NN
cord-002530-ao7kenbx	193	29	.	.	.
cord-002530-ao7kenbx	194	1	Studies	study	NNS
cord-002530-ao7kenbx	194	2	in	in	IN
cord-002530-ao7kenbx	194	3	yeast	yeast	NN
cord-002530-ao7kenbx	194	4	and	and	CC
cord-002530-ao7kenbx	194	5	mammalian	mammalian	JJ
cord-002530-ao7kenbx	194	6	cell	cell	NN
cord-002530-ao7kenbx	194	7	lines	line	NNS
cord-002530-ao7kenbx	194	8	have	have	VBP
cord-002530-ao7kenbx	194	9	demonstrated	demonstrate	VBN
cord-002530-ao7kenbx	194	10	that	that	IN
cord-002530-ao7kenbx	194	11	VCP	VCP	NNP
cord-002530-ao7kenbx	194	12	modulates	modulate	VBZ
cord-002530-ao7kenbx	194	13	the	the	DT
cord-002530-ao7kenbx	194	14	association	association	NN
cord-002530-ao7kenbx	194	15	of	of	IN
cord-002530-ao7kenbx	194	16	factors	factor	NNS
cord-002530-ao7kenbx	194	17	with	with	IN
cord-002530-ao7kenbx	194	18	chromatin	chromatin	NN
cord-002530-ao7kenbx	194	19	,	,	,
cord-002530-ao7kenbx	194	20	leading	lead	VBG
cord-002530-ao7kenbx	194	21	to	to	IN
cord-002530-ao7kenbx	194	22	regulation	regulation	NN
cord-002530-ao7kenbx	194	23	of	of	IN
cord-002530-ao7kenbx	194	24	cell	cell	NN
cord-002530-ao7kenbx	194	25	cycle	cycle	NN
cord-002530-ao7kenbx	194	26	,	,	,
cord-002530-ao7kenbx	194	27	transcription	transcription	NN
cord-002530-ao7kenbx	194	28	,	,	,
cord-002530-ao7kenbx	194	29	DNA	dna	NN
cord-002530-ao7kenbx	194	30	replication	replication	NN
cord-002530-ao7kenbx	194	31	and	and	CC
cord-002530-ao7kenbx	194	32	DNA	dna	NN
cord-002530-ao7kenbx	194	33	damage	damage	NN
cord-002530-ao7kenbx	194	34	response	response	NN
cord-002530-ao7kenbx	194	35	,	,	,
cord-002530-ao7kenbx	194	36	all	all	DT
cord-002530-ao7kenbx	194	37	of	of	IN
cord-002530-ao7kenbx	194	38	which	which	WDT
cord-002530-ao7kenbx	194	39	could	could	MD
cord-002530-ao7kenbx	194	40	potentially	potentially	RB
cord-002530-ao7kenbx	194	41	affect	affect	VB
cord-002530-ao7kenbx	194	42	virus	virus	NN
cord-002530-ao7kenbx	194	43	replication	replication	NN
cord-002530-ao7kenbx	194	44	and	and	CC
cord-002530-ao7kenbx	194	45	MIE	MIE	NNP
cord-002530-ao7kenbx	194	46	expression	expression	NN
cord-002530-ao7kenbx	194	47	[	[	-LRB-
cord-002530-ao7kenbx	194	48	21	21	CD
cord-002530-ao7kenbx	194	49	]	]	-RRB-
cord-002530-ao7kenbx	194	50	.	.	.
cord-002530-ao7kenbx	195	1	Previous	previous	JJ
cord-002530-ao7kenbx	195	2	reports	report	NNS
cord-002530-ao7kenbx	195	3	have	have	VBP
cord-002530-ao7kenbx	195	4	shown	show	VBN
cord-002530-ao7kenbx	195	5	that	that	IN
cord-002530-ao7kenbx	195	6	HCMV	HCMV	NNP
cord-002530-ao7kenbx	195	7	induces	induce	VBZ
cord-002530-ao7kenbx	195	8	the	the	DT
cord-002530-ao7kenbx	195	9	host	host	NN
cord-002530-ao7kenbx	195	10	DNA	dna	NN
cord-002530-ao7kenbx	195	11	damage	damage	NN
cord-002530-ao7kenbx	195	12	response	response	NN
cord-002530-ao7kenbx	195	13	,	,	,
cord-002530-ao7kenbx	195	14	with	with	IN
cord-002530-ao7kenbx	195	15	response	response	NN
cord-002530-ao7kenbx	195	16	factors	factor	NNS
cord-002530-ao7kenbx	195	17	including	include	VBG
cord-002530-ao7kenbx	195	18	ATM	atm	NN
cord-002530-ao7kenbx	195	19	,	,	,
cord-002530-ao7kenbx	195	20	γH2AX	γH2AX	NNP
cord-002530-ao7kenbx	195	21	and	and	CC
cord-002530-ao7kenbx	195	22	E2F1	E2F1	NNP
cord-002530-ao7kenbx	195	23	required	require	VBD
cord-002530-ao7kenbx	195	24	for	for	IN
cord-002530-ao7kenbx	195	25	efficient	efficient	JJ
cord-002530-ao7kenbx	195	26	HCMV	HCMV	NNP
cord-002530-ao7kenbx	195	27	replication	replication	NN
cord-002530-ao7kenbx	195	28	and	and	CC
cord-002530-ao7kenbx	195	29	IE2	ie2	JJ
cord-002530-ao7kenbx	195	30	expression	expression	NN
cord-002530-ao7kenbx	195	31	[	[	-LRB-
cord-002530-ao7kenbx	195	32	42	42	CD
cord-002530-ao7kenbx	195	33	]	]	-RRB-
cord-002530-ao7kenbx	195	34	.	.	.
cord-002530-ao7kenbx	196	1	γH2AX	γH2AX	NNP
cord-002530-ao7kenbx	196	2	also	also	RB
cord-002530-ao7kenbx	196	3	colocalises	colocalise	VBZ
cord-002530-ao7kenbx	196	4	with	with	IN
cord-002530-ao7kenbx	196	5	the	the	DT
cord-002530-ao7kenbx	196	6	viral	viral	JJ
cord-002530-ao7kenbx	196	7	replication	replication	NN
cord-002530-ao7kenbx	196	8	compartments	compartment	NNS
cord-002530-ao7kenbx	196	9	in	in	IN
cord-002530-ao7kenbx	196	10	the	the	DT
cord-002530-ao7kenbx	196	11	nucleus	nucleus	NN
cord-002530-ao7kenbx	196	12	.	.	.
cord-002530-ao7kenbx	197	1	VCP	VCP	NNP
cord-002530-ao7kenbx	197	2	acts	act	VBZ
cord-002530-ao7kenbx	197	3	downstream	downstream	RB
cord-002530-ao7kenbx	197	4	of	of	IN
cord-002530-ao7kenbx	197	5	ATM	atm	NN
cord-002530-ao7kenbx	197	6	and	and	CC
cord-002530-ao7kenbx	197	7	is	be	VBZ
cord-002530-ao7kenbx	197	8	required	require	VBN
cord-002530-ao7kenbx	197	9	for	for	IN
cord-002530-ao7kenbx	197	10	the	the	DT
cord-002530-ao7kenbx	197	11	removal	removal	NN
cord-002530-ao7kenbx	197	12	of	of	IN
cord-002530-ao7kenbx	197	13	ubiquitinated	ubiquitinated	JJ
cord-002530-ao7kenbx	197	14	factors	factor	NNS
cord-002530-ao7kenbx	197	15	associated	associate	VBN
cord-002530-ao7kenbx	197	16	with	with	IN
cord-002530-ao7kenbx	197	17	dsDNA	dsdna	JJ
cord-002530-ao7kenbx	197	18	break	break	NN
cord-002530-ao7kenbx	197	19	regions	region	NNS
cord-002530-ao7kenbx	197	20	,	,	,
cord-002530-ao7kenbx	197	21	allowing	allow	VBG
cord-002530-ao7kenbx	197	22	repair	repair	NN
cord-002530-ao7kenbx	197	23	to	to	TO
cord-002530-ao7kenbx	197	24	proceed	proceed	VB
cord-002530-ao7kenbx	197	25	[	[	-LRB-
cord-002530-ao7kenbx	197	26	21	21	CD
cord-002530-ao7kenbx	197	27	]	]	-RRB-
cord-002530-ao7kenbx	197	28	.	.	.
cord-002530-ao7kenbx	198	1	If	if	IN
cord-002530-ao7kenbx	198	2	knockdown	knockdown	NN
cord-002530-ao7kenbx	198	3	of	of	IN
cord-002530-ao7kenbx	198	4	VCP	VCP	NNP
cord-002530-ao7kenbx	198	5	disrupts	disrupt	VBZ
cord-002530-ao7kenbx	198	6	the	the	DT
cord-002530-ao7kenbx	198	7	DNA	dna	NN
cord-002530-ao7kenbx	198	8	damage	damage	NN
cord-002530-ao7kenbx	198	9	response	response	NN
cord-002530-ao7kenbx	198	10	during	during	IN
cord-002530-ao7kenbx	198	11	HCMV	HCMV	NNP
cord-002530-ao7kenbx	198	12	infection	infection	NN
cord-002530-ao7kenbx	198	13	,	,	,
cord-002530-ao7kenbx	198	14	this	this	DT
cord-002530-ao7kenbx	198	15	could	could	MD
cord-002530-ao7kenbx	198	16	contribute	contribute	VB
cord-002530-ao7kenbx	198	17	to	to	IN
cord-002530-ao7kenbx	198	18	the	the	DT
cord-002530-ao7kenbx	198	19	observed	observed	JJ
cord-002530-ao7kenbx	198	20	loss	loss	NN
cord-002530-ao7kenbx	198	21	of	of	IN
cord-002530-ao7kenbx	198	22	IE2	ie2	JJ
cord-002530-ao7kenbx	198	23	expression	expression	NN
cord-002530-ao7kenbx	198	24	and	and	CC
cord-002530-ao7kenbx	198	25	inhibition	inhibition	NN
cord-002530-ao7kenbx	198	26	of	of	IN
cord-002530-ao7kenbx	198	27	virus	virus	NN
cord-002530-ao7kenbx	198	28	replication	replication	NN
cord-002530-ao7kenbx	198	29	.	.	.
cord-002530-ao7kenbx	199	1	Reports	report	NNS
cord-002530-ao7kenbx	199	2	are	be	VBP
cord-002530-ao7kenbx	199	3	also	also	RB
cord-002530-ao7kenbx	199	4	emerging	emerge	VBG
cord-002530-ao7kenbx	199	5	that	that	IN
cord-002530-ao7kenbx	199	6	VCP	VCP	NNP
cord-002530-ao7kenbx	199	7	plays	play	VBZ
cord-002530-ao7kenbx	199	8	a	a	DT
cord-002530-ao7kenbx	199	9	role	role	NN
cord-002530-ao7kenbx	199	10	in	in	IN
cord-002530-ao7kenbx	199	11	transcript	transcript	NN
cord-002530-ao7kenbx	199	12	stability	stability	NN
cord-002530-ao7kenbx	199	13	and	and	CC
cord-002530-ao7kenbx	199	14	regulation	regulation	NN
cord-002530-ao7kenbx	199	15	of	of	IN
cord-002530-ao7kenbx	199	16	splicing	splicing	NN
cord-002530-ao7kenbx	199	17	.	.	.
cord-002530-ao7kenbx	200	1	HuR	HuR	NNP
cord-002530-ao7kenbx	200	2	is	be	VBZ
cord-002530-ao7kenbx	200	3	a	a	DT
cord-002530-ao7kenbx	200	4	RNA	RNA	NNP
cord-002530-ao7kenbx	200	5	binding	bind	VBG
cord-002530-ao7kenbx	200	6	protein	protein	NN
cord-002530-ao7kenbx	200	7	that	that	WDT
cord-002530-ao7kenbx	200	8	stabilizes	stabilize	VBZ
cord-002530-ao7kenbx	200	9	transcripts	transcript	NNS
cord-002530-ao7kenbx	200	10	by	by	IN
cord-002530-ao7kenbx	200	11	binding	bind	VBG
cord-002530-ao7kenbx	200	12	to	to	IN
cord-002530-ao7kenbx	200	13	canonical	canonical	JJ
cord-002530-ao7kenbx	200	14	AU	AU	NNP
cord-002530-ao7kenbx	200	15	rich	rich	JJ
cord-002530-ao7kenbx	200	16	regions	region	NNS
cord-002530-ao7kenbx	200	17	within	within	IN
cord-002530-ao7kenbx	200	18	3'UTRs	3'utrs	CD
cord-002530-ao7kenbx	200	19	.	.	.
cord-002530-ao7kenbx	201	1	Following	follow	VBG
cord-002530-ao7kenbx	201	2	ubiquitination	ubiquitination	NN
cord-002530-ao7kenbx	201	3	of	of	IN
cord-002530-ao7kenbx	201	4	HuR	hur	NN
cord-002530-ao7kenbx	201	5	in	in	IN
cord-002530-ao7kenbx	201	6	response	response	NN
cord-002530-ao7kenbx	201	7	to	to	IN
cord-002530-ao7kenbx	201	8	stress	stress	NN
cord-002530-ao7kenbx	201	9	signals	signal	NNS
cord-002530-ao7kenbx	201	10	,	,	,
cord-002530-ao7kenbx	201	11	VCP	VCP	NNP
cord-002530-ao7kenbx	201	12	removes	remove	VBZ
cord-002530-ao7kenbx	201	13	HuR	hur	NN
cord-002530-ao7kenbx	201	14	from	from	IN
cord-002530-ao7kenbx	201	15	associated	associate	VBN
cord-002530-ao7kenbx	201	16	transcripts	transcript	NNS
cord-002530-ao7kenbx	201	17	resulting	result	VBG
cord-002530-ao7kenbx	201	18	in	in	IN
cord-002530-ao7kenbx	201	19	transcript	transcript	NN
cord-002530-ao7kenbx	201	20	destabilization	destabilization	NN
cord-002530-ao7kenbx	201	21	[	[	-LRB-
cord-002530-ao7kenbx	201	22	43	43	CD
cord-002530-ao7kenbx	201	23	]	]	-RRB-
cord-002530-ao7kenbx	201	24	.	.	.
cord-002530-ao7kenbx	202	1	In	in	IN
cord-002530-ao7kenbx	202	2	Drosophila	Drosophila	NNP
cord-002530-ao7kenbx	202	3	,	,	,
cord-002530-ao7kenbx	202	4	VCP	VCP	NNP
cord-002530-ao7kenbx	202	5	has	have	VBZ
cord-002530-ao7kenbx	202	6	been	be	VBN
cord-002530-ao7kenbx	202	7	linked	link	VBN
cord-002530-ao7kenbx	202	8	to	to	IN
cord-002530-ao7kenbx	202	9	dendrite	dendrite	NN
cord-002530-ao7kenbx	202	10	pruning	pruning	NN
cord-002530-ao7kenbx	202	11	in	in	IN
cord-002530-ao7kenbx	202	12	neuronal	neuronal	JJ
cord-002530-ao7kenbx	202	13	cells	cell	NNS
cord-002530-ao7kenbx	202	14	[	[	-LRB-
cord-002530-ao7kenbx	202	15	44	44	CD
cord-002530-ao7kenbx	202	16	]	]	-RRB-
cord-002530-ao7kenbx	202	17	.	.	.
cord-002530-ao7kenbx	203	1	Expression	expression	NN
cord-002530-ao7kenbx	203	2	of	of	IN
cord-002530-ao7kenbx	203	3	mutant	mutant	JJ
cord-002530-ao7kenbx	203	4	forms	form	NNS
cord-002530-ao7kenbx	203	5	of	of	IN
cord-002530-ao7kenbx	203	6	VCP	vcp	NN
cord-002530-ao7kenbx	203	7	results	result	NNS
cord-002530-ao7kenbx	203	8	in	in	IN
cord-002530-ao7kenbx	203	9	incorrect	incorrect	JJ
cord-002530-ao7kenbx	203	10	splicing	splicing	NN
cord-002530-ao7kenbx	203	11	of	of	IN
cord-002530-ao7kenbx	203	12	a	a	DT
cord-002530-ao7kenbx	203	13	gene	gene	NN
cord-002530-ao7kenbx	203	14	important	important	JJ
cord-002530-ao7kenbx	203	15	to	to	IN
cord-002530-ao7kenbx	203	16	dendritic	dendritic	JJ
cord-002530-ao7kenbx	203	17	pruning	pruning	NN
cord-002530-ao7kenbx	203	18	,	,	,
cord-002530-ao7kenbx	203	19	MICAL	MICAL	NNP
cord-002530-ao7kenbx	203	20	,	,	,
cord-002530-ao7kenbx	203	21	possibly	possibly	RB
cord-002530-ao7kenbx	203	22	through	through	IN
cord-002530-ao7kenbx	203	23	mis	mis	NN
cord-002530-ao7kenbx	203	24	-	-	HYPH
cord-002530-ao7kenbx	203	25	localisation	localisation	NN
cord-002530-ao7kenbx	203	26	of	of	IN
cord-002530-ao7kenbx	203	27	the	the	DT
cord-002530-ao7kenbx	203	28	RNA	RNA	NNP
cord-002530-ao7kenbx	203	29	binding	binding	NN
cord-002530-ao7kenbx	203	30	protein	protein	NN
cord-002530-ao7kenbx	203	31	TDP-43	TDP-43	NNP
cord-002530-ao7kenbx	203	32	.	.	.
cord-002530-ao7kenbx	204	1	Given	give	VBN
cord-002530-ao7kenbx	204	2	the	the	DT
cord-002530-ao7kenbx	204	3	known	know	VBN
cord-002530-ao7kenbx	204	4	mechanism	mechanism	NN
cord-002530-ao7kenbx	204	5	of	of	IN
cord-002530-ao7kenbx	204	6	action	action	NN
cord-002530-ao7kenbx	204	7	of	of	IN
cord-002530-ao7kenbx	204	8	VCP	VCP	NNP
cord-002530-ao7kenbx	204	9	it	-PRON-	PRP
cord-002530-ao7kenbx	204	10	is	be	VBZ
cord-002530-ao7kenbx	204	11	likely	likely	JJ
cord-002530-ao7kenbx	204	12	that	that	IN
cord-002530-ao7kenbx	204	13	any	any	DT
cord-002530-ao7kenbx	204	14	effects	effect	NNS
cord-002530-ao7kenbx	204	15	on	on	IN
cord-002530-ao7kenbx	204	16	MIE	mie	NN
cord-002530-ao7kenbx	204	17	splicing	splicing	NN
cord-002530-ao7kenbx	204	18	are	be	VBP
cord-002530-ao7kenbx	204	19	indirect	indirect	JJ
cord-002530-ao7kenbx	204	20	,	,	,
cord-002530-ao7kenbx	204	21	occurring	occur	VBG
cord-002530-ao7kenbx	204	22	through	through	IN
cord-002530-ao7kenbx	204	23	targeting	targeting	NN
cord-002530-ao7kenbx	204	24	of	of	IN
cord-002530-ao7kenbx	204	25	a	a	DT
cord-002530-ao7kenbx	204	26	ubiquitinated	ubiquitinated	JJ
cord-002530-ao7kenbx	204	27	intermediate	intermediate	JJ
cord-002530-ao7kenbx	204	28	protein	protein	NN
cord-002530-ao7kenbx	204	29	.	.	.
cord-002530-ao7kenbx	205	1	One	one	CD
cord-002530-ao7kenbx	205	2	possible	possible	JJ
cord-002530-ao7kenbx	205	3	model	model	NN
cord-002530-ao7kenbx	205	4	is	be	VBZ
cord-002530-ao7kenbx	205	5	that	that	IN
cord-002530-ao7kenbx	205	6	a	a	DT
cord-002530-ao7kenbx	205	7	negative	negative	JJ
cord-002530-ao7kenbx	205	8	regulator	regulator	NN
cord-002530-ao7kenbx	205	9	of	of	IN
cord-002530-ao7kenbx	205	10	IE2	ie2	JJ
cord-002530-ao7kenbx	205	11	splicing	splicing	NN
cord-002530-ao7kenbx	205	12	exists	exist	VBZ
cord-002530-ao7kenbx	205	13	at	at	IN
cord-002530-ao7kenbx	205	14	early	early	JJ
cord-002530-ao7kenbx	205	15	stages	stage	NNS
cord-002530-ao7kenbx	205	16	during	during	IN
cord-002530-ao7kenbx	205	17	HCMV	HCMV	NNP
cord-002530-ao7kenbx	205	18	infection	infection	NN
cord-002530-ao7kenbx	205	19	,	,	,
cord-002530-ao7kenbx	205	20	which	which	WDT
cord-002530-ao7kenbx	205	21	promotes	promote	VBZ
cord-002530-ao7kenbx	205	22	IE1	ie1	NN
cord-002530-ao7kenbx	205	23	expression	expression	NN
cord-002530-ao7kenbx	205	24	at	at	IN
cord-002530-ao7kenbx	205	25	the	the	DT
cord-002530-ao7kenbx	205	26	expense	expense	NN
cord-002530-ao7kenbx	205	27	of	of	IN
cord-002530-ao7kenbx	205	28	IE2	ie2	JJ
cord-002530-ao7kenbx	205	29	expression	expression	NN
cord-002530-ao7kenbx	205	30	.	.	.
cord-002530-ao7kenbx	206	1	Based	base	VBN
cord-002530-ao7kenbx	206	2	on	on	IN
cord-002530-ao7kenbx	206	3	the	the	DT
cord-002530-ao7kenbx	206	4	transcriptional	transcriptional	JJ
cord-002530-ao7kenbx	206	5	architecture	architecture	NN
cord-002530-ao7kenbx	206	6	of	of	IN
cord-002530-ao7kenbx	206	7	the	the	DT
cord-002530-ao7kenbx	206	8	major	major	JJ
cord-002530-ao7kenbx	206	9	immediate	immediate	JJ
cord-002530-ao7kenbx	206	10	region	region	NN
cord-002530-ao7kenbx	206	11	,	,	,
cord-002530-ao7kenbx	206	12	such	such	PDT
cord-002530-ao7kenbx	206	13	a	a	DT
cord-002530-ao7kenbx	206	14	factor	factor	NN
cord-002530-ao7kenbx	206	15	could	could	MD
cord-002530-ao7kenbx	206	16	regulate	regulate	VB
cord-002530-ao7kenbx	206	17	MIE	MIE	NNP
cord-002530-ao7kenbx	206	18	splicing	splicing	NN
cord-002530-ao7kenbx	206	19	by	by	IN
cord-002530-ao7kenbx	206	20	promoting	promote	VBG
cord-002530-ao7kenbx	206	21	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	206	22	of	of	IN
cord-002530-ao7kenbx	206	23	the	the	DT
cord-002530-ao7kenbx	206	24	IE1	ie1	NN
cord-002530-ao7kenbx	206	25	transcript	transcript	NN
cord-002530-ao7kenbx	206	26	,	,	,
cord-002530-ao7kenbx	206	27	thereby	thereby	RB
cord-002530-ao7kenbx	206	28	inhibiting	inhibit	VBG
cord-002530-ao7kenbx	206	29	read	read	VBN
cord-002530-ao7kenbx	206	30	-	-	HYPH
cord-002530-ao7kenbx	206	31	through	through	NN
cord-002530-ao7kenbx	206	32	to	to	IN
cord-002530-ao7kenbx	206	33	the	the	DT
cord-002530-ao7kenbx	206	34	IE2	ie2	JJ
cord-002530-ao7kenbx	206	35	final	final	JJ
cord-002530-ao7kenbx	206	36	exon	exon	NN
cord-002530-ao7kenbx	206	37	.	.	.
cord-002530-ao7kenbx	207	1	The	the	DT
cord-002530-ao7kenbx	207	2	factor	factor	NN
cord-002530-ao7kenbx	207	3	would	would	MD
cord-002530-ao7kenbx	207	4	be	be	VB
cord-002530-ao7kenbx	207	5	ubiquitinated	ubiquitinate	VBN
cord-002530-ao7kenbx	207	6	and	and	CC
cord-002530-ao7kenbx	207	7	removed	remove	VBN
cord-002530-ao7kenbx	207	8	by	by	IN
cord-002530-ao7kenbx	207	9	VCP	VCP	NNP
cord-002530-ao7kenbx	207	10	between	between	IN
cord-002530-ao7kenbx	207	11	12	12	CD
cord-002530-ao7kenbx	207	12	and	and	CC
cord-002530-ao7kenbx	207	13	24	24	CD
cord-002530-ao7kenbx	207	14	HPI	HPI	NNP
cord-002530-ao7kenbx	207	15	,	,	,
cord-002530-ao7kenbx	207	16	allowing	allow	VBG
cord-002530-ao7kenbx	207	17	read	read	VBN
cord-002530-ao7kenbx	207	18	-	-	HYPH
cord-002530-ao7kenbx	207	19	through	through	NN
cord-002530-ao7kenbx	207	20	of	of	IN
cord-002530-ao7kenbx	207	21	the	the	DT
cord-002530-ao7kenbx	207	22	first	first	JJ
cord-002530-ao7kenbx	207	23	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	207	24	site	site	NN
cord-002530-ao7kenbx	207	25	and	and	CC
cord-002530-ao7kenbx	207	26	splicing	splicing	NN
cord-002530-ao7kenbx	207	27	of	of	IN
cord-002530-ao7kenbx	207	28	the	the	DT
cord-002530-ao7kenbx	207	29	IE2	ie2	JJ
cord-002530-ao7kenbx	207	30	transcript	transcript	NN
cord-002530-ao7kenbx	207	31	.	.	.
cord-002530-ao7kenbx	208	1	This	this	DT
cord-002530-ao7kenbx	208	2	would	would	MD
cord-002530-ao7kenbx	208	3	be	be	VB
cord-002530-ao7kenbx	208	4	consistent	consistent	JJ
cord-002530-ao7kenbx	208	5	with	with	IN
cord-002530-ao7kenbx	208	6	the	the	DT
cord-002530-ao7kenbx	208	7	initial	initial	JJ
cord-002530-ao7kenbx	208	8	plateau	plateau	NN
cord-002530-ao7kenbx	208	9	in	in	IN
cord-002530-ao7kenbx	208	10	IE2	ie2	JJ
cord-002530-ao7kenbx	208	11	transcription	transcription	NN
cord-002530-ao7kenbx	208	12	and	and	CC
cord-002530-ao7kenbx	208	13	localisation	localisation	NN
cord-002530-ao7kenbx	208	14	of	of	IN
cord-002530-ao7kenbx	208	15	VCP	VCP	NNP
cord-002530-ao7kenbx	208	16	to	to	IN
cord-002530-ao7kenbx	208	17	the	the	DT
cord-002530-ao7kenbx	208	18	replication	replication	NN
cord-002530-ao7kenbx	208	19	compartments	compartment	NNS
cord-002530-ao7kenbx	208	20	at	at	IN
cord-002530-ao7kenbx	208	21	12	12	CD
cord-002530-ao7kenbx	208	22	to	to	TO
cord-002530-ao7kenbx	208	23	24	24	CD
cord-002530-ao7kenbx	208	24	HPI	HPI	NNP
cord-002530-ao7kenbx	208	25	,	,	,
cord-002530-ao7kenbx	208	26	where	where	WRB
cord-002530-ao7kenbx	208	27	spliceosome	spliceosome	NNP
cord-002530-ao7kenbx	208	28	and	and	CC
cord-002530-ao7kenbx	208	29	proteasome	proteasome	NN
cord-002530-ao7kenbx	208	30	components	component	NNS
cord-002530-ao7kenbx	208	31	have	have	VBP
cord-002530-ao7kenbx	208	32	also	also	RB
cord-002530-ao7kenbx	208	33	been	be	VBN
cord-002530-ao7kenbx	208	34	reported	report	VBN
cord-002530-ao7kenbx	208	35	to	to	IN
cord-002530-ao7kenbx	208	36	colocalise	colocalise	NNP
cord-002530-ao7kenbx	208	37	[	[	-LRB-
cord-002530-ao7kenbx	208	38	30	30	CD
cord-002530-ao7kenbx	208	39	,	,	,
cord-002530-ao7kenbx	208	40	45	45	CD
cord-002530-ao7kenbx	208	41	]	]	-RRB-
cord-002530-ao7kenbx	208	42	.	.	.
cord-002530-ao7kenbx	209	1	The	the	DT
cord-002530-ao7kenbx	209	2	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	209	3	data	datum	NNS
cord-002530-ao7kenbx	209	4	also	also	RB
cord-002530-ao7kenbx	209	5	supports	support	VBZ
cord-002530-ao7kenbx	209	6	this	this	DT
cord-002530-ao7kenbx	209	7	model	model	NN
cord-002530-ao7kenbx	209	8	,	,	,
cord-002530-ao7kenbx	209	9	with	with	IN
cord-002530-ao7kenbx	209	10	inhibition	inhibition	NN
cord-002530-ao7kenbx	209	11	of	of	IN
cord-002530-ao7kenbx	209	12	IE2	ie2	JJ
cord-002530-ao7kenbx	209	13	expression	expression	NN
cord-002530-ao7kenbx	209	14	only	only	RB
cord-002530-ao7kenbx	209	15	effective	effective	JJ
cord-002530-ao7kenbx	209	16	with	with	IN
cord-002530-ao7kenbx	209	17	either	either	DT
cord-002530-ao7kenbx	209	18	pre	pre	JJ
cord-002530-ao7kenbx	209	19	-	-	JJ
cord-002530-ao7kenbx	209	20	treatment	treatment	JJ
cord-002530-ao7kenbx	209	21	or	or	CC
cord-002530-ao7kenbx	209	22	addition	addition	NN
cord-002530-ao7kenbx	209	23	of	of	IN
cord-002530-ao7kenbx	209	24	the	the	DT
cord-002530-ao7kenbx	209	25	drug	drug	NN
cord-002530-ao7kenbx	209	26	at	at	IN
cord-002530-ao7kenbx	209	27	the	the	DT
cord-002530-ao7kenbx	209	28	same	same	JJ
cord-002530-ao7kenbx	209	29	time	time	NN
cord-002530-ao7kenbx	209	30	as	as	IN
cord-002530-ao7kenbx	209	31	infection	infection	NN
cord-002530-ao7kenbx	209	32	.	.	.
cord-002530-ao7kenbx	210	1	Treatment	treatment	NN
cord-002530-ao7kenbx	210	2	at	at	IN
cord-002530-ao7kenbx	210	3	24	24	CD
cord-002530-ao7kenbx	210	4	HPI	HPI	NNP
cord-002530-ao7kenbx	210	5	was	be	VBD
cord-002530-ao7kenbx	210	6	ineffective	ineffective	JJ
cord-002530-ao7kenbx	210	7	at	at	IN
cord-002530-ao7kenbx	210	8	blocking	block	VBG
cord-002530-ao7kenbx	210	9	IE2	ie2	JJ
cord-002530-ao7kenbx	210	10	expression	expression	NN
cord-002530-ao7kenbx	210	11	,	,	,
cord-002530-ao7kenbx	210	12	suggesting	suggest	VBG
cord-002530-ao7kenbx	210	13	a	a	DT
cord-002530-ao7kenbx	210	14	window	window	NN
cord-002530-ao7kenbx	210	15	in	in	IN
cord-002530-ao7kenbx	210	16	which	which	WDT
cord-002530-ao7kenbx	210	17	VCP	vcp	NN
cord-002530-ao7kenbx	210	18	activity	activity	NN
cord-002530-ao7kenbx	210	19	is	be	VBZ
cord-002530-ao7kenbx	210	20	required	require	VBN
cord-002530-ao7kenbx	210	21	for	for	IN
cord-002530-ao7kenbx	210	22	regulation	regulation	NN
cord-002530-ao7kenbx	210	23	of	of	IN
cord-002530-ao7kenbx	210	24	MIE	MIE	NNP
cord-002530-ao7kenbx	210	25	splicing	splicing	NN
cord-002530-ao7kenbx	210	26	.	.	.
cord-002530-ao7kenbx	211	1	Interestingly	interestingly	RB
cord-002530-ao7kenbx	211	2	,	,	,
cord-002530-ao7kenbx	211	3	blocking	block	VBG
cord-002530-ao7kenbx	211	4	de	de	IN
cord-002530-ao7kenbx	211	5	novo	novo	NNP
cord-002530-ao7kenbx	211	6	protein	protein	NN
cord-002530-ao7kenbx	211	7	translation	translation	NN
cord-002530-ao7kenbx	211	8	by	by	IN
cord-002530-ao7kenbx	211	9	cycloheximide	cycloheximide	NN
cord-002530-ao7kenbx	211	10	treatment	treatment	NN
cord-002530-ao7kenbx	211	11	,	,	,
cord-002530-ao7kenbx	211	12	effectively	effectively	RB
cord-002530-ao7kenbx	211	13	rescues	rescue	VBZ
cord-002530-ao7kenbx	211	14	IE2	ie2	NN
cord-002530-ao7kenbx	211	15	transcription	transcription	NN
cord-002530-ao7kenbx	211	16	following	follow	VBG
cord-002530-ao7kenbx	211	17	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	211	18	treatment	treatment	NN
cord-002530-ao7kenbx	211	19	,	,	,
cord-002530-ao7kenbx	211	20	suggesting	suggest	VBG
cord-002530-ao7kenbx	211	21	the	the	DT
cord-002530-ao7kenbx	211	22	inhibitory	inhibitory	JJ
cord-002530-ao7kenbx	211	23	factor	factor	NN
cord-002530-ao7kenbx	211	24	is	be	VBZ
cord-002530-ao7kenbx	211	25	induced	induce	VBN
cord-002530-ao7kenbx	211	26	by	by	IN
cord-002530-ao7kenbx	211	27	virus	virus	NN
cord-002530-ao7kenbx	211	28	infection	infection	NN
cord-002530-ao7kenbx	211	29	(	(	-LRB-
cord-002530-ao7kenbx	211	30	S11	S11	NNP
cord-002530-ao7kenbx	211	31	Fig	Fig	NNP
cord-002530-ao7kenbx	211	32	)	)	-RRB-
cord-002530-ao7kenbx	211	33	.	.	.
cord-002530-ao7kenbx	212	1	Although	although	IN
cord-002530-ao7kenbx	212	2	not	not	RB
cord-002530-ao7kenbx	212	3	common	common	JJ
cord-002530-ao7kenbx	212	4	,	,	,
cord-002530-ao7kenbx	212	5	there	there	EX
cord-002530-ao7kenbx	212	6	are	be	VBP
cord-002530-ao7kenbx	212	7	a	a	DT
cord-002530-ao7kenbx	212	8	number	number	NN
cord-002530-ao7kenbx	212	9	of	of	IN
cord-002530-ao7kenbx	212	10	examples	example	NNS
cord-002530-ao7kenbx	212	11	of	of	IN
cord-002530-ao7kenbx	212	12	terminal	terminal	NN
cord-002530-ao7kenbx	212	13	exon	exon	NN
cord-002530-ao7kenbx	212	14	skipping	skip	VBG
cord-002530-ao7kenbx	212	15	in	in	IN
cord-002530-ao7kenbx	212	16	the	the	DT
cord-002530-ao7kenbx	212	17	human	human	JJ
cord-002530-ao7kenbx	212	18	genome	genome	NN
cord-002530-ao7kenbx	212	19	,	,	,
cord-002530-ao7kenbx	212	20	which	which	WDT
cord-002530-ao7kenbx	212	21	would	would	MD
cord-002530-ao7kenbx	212	22	be	be	VB
cord-002530-ao7kenbx	212	23	analogous	analogous	JJ
cord-002530-ao7kenbx	212	24	to	to	IN
cord-002530-ao7kenbx	212	25	the	the	DT
cord-002530-ao7kenbx	212	26	proposed	propose	VBN
cord-002530-ao7kenbx	212	27	model	model	NN
cord-002530-ao7kenbx	212	28	.	.	.
cord-002530-ao7kenbx	213	1	Maturation	maturation	NN
cord-002530-ao7kenbx	213	2	of	of	IN
cord-002530-ao7kenbx	213	3	B	b	NN
cord-002530-ao7kenbx	213	4	cells	cell	NNS
cord-002530-ao7kenbx	213	5	to	to	IN
cord-002530-ao7kenbx	213	6	differentiated	differentiated	JJ
cord-002530-ao7kenbx	213	7	plasma	plasma	NN
cord-002530-ao7kenbx	213	8	cells	cell	NNS
cord-002530-ao7kenbx	213	9	results	result	NNS
cord-002530-ao7kenbx	213	10	in	in	IN
cord-002530-ao7kenbx	213	11	a	a	DT
cord-002530-ao7kenbx	213	12	switch	switch	NN
cord-002530-ao7kenbx	213	13	from	from	IN
cord-002530-ao7kenbx	213	14	predominantly	predominantly	RB
cord-002530-ao7kenbx	213	15	membrane	membrane	NN
cord-002530-ao7kenbx	213	16	bound	bind	VBN
cord-002530-ao7kenbx	213	17	IgM	IgM	NNP
cord-002530-ao7kenbx	213	18	to	to	IN
cord-002530-ao7kenbx	213	19	secreted	secrete	VBN
cord-002530-ao7kenbx	213	20	IgM.	IgM.	NNP
cord-002530-ao7kenbx	213	21	Studies	Studies	NNP
cord-002530-ao7kenbx	214	1	have	have	VBP
cord-002530-ao7kenbx	214	2	shown	show	VBN
cord-002530-ao7kenbx	214	3	that	that	IN
cord-002530-ao7kenbx	214	4	increased	increase	VBN
cord-002530-ao7kenbx	214	5	expression	expression	NN
cord-002530-ao7kenbx	214	6	of	of	IN
cord-002530-ao7kenbx	214	7	the	the	DT
cord-002530-ao7kenbx	214	8	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	214	9	factor	factor	NN
cord-002530-ao7kenbx	214	10	cstF-64	cstF-64	NNP
cord-002530-ao7kenbx	214	11	promotes	promote	VBZ
cord-002530-ao7kenbx	214	12	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	214	13	upstream	upstream	RB
cord-002530-ao7kenbx	214	14	of	of	IN
cord-002530-ao7kenbx	214	15	the	the	DT
cord-002530-ao7kenbx	214	16	exons	exon	NNS
cord-002530-ao7kenbx	214	17	required	require	VBN
cord-002530-ao7kenbx	214	18	for	for	IN
cord-002530-ao7kenbx	214	19	membrane	membrane	NN
cord-002530-ao7kenbx	214	20	bound	bind	VBN
cord-002530-ao7kenbx	214	21	IgM	IgM	NNP
cord-002530-ao7kenbx	214	22	resulting	result	VBG
cord-002530-ao7kenbx	214	23	in	in	IN
cord-002530-ao7kenbx	214	24	increased	increase	VBN
cord-002530-ao7kenbx	214	25	expression	expression	NN
cord-002530-ao7kenbx	214	26	of	of	IN
cord-002530-ao7kenbx	214	27	the	the	DT
cord-002530-ao7kenbx	214	28	secreted	secrete	VBN
cord-002530-ao7kenbx	214	29	form	form	NN
cord-002530-ao7kenbx	214	30	[	[	-LRB-
cord-002530-ao7kenbx	214	31	46	46	CD
cord-002530-ao7kenbx	214	32	,	,	,
cord-002530-ao7kenbx	214	33	47	47	CD
cord-002530-ao7kenbx	214	34	]	]	-RRB-
cord-002530-ao7kenbx	214	35	.	.	.
cord-002530-ao7kenbx	215	1	Tissue	tissue	NN
cord-002530-ao7kenbx	215	2	specific	specific	JJ
cord-002530-ao7kenbx	215	3	regulation	regulation	NN
cord-002530-ao7kenbx	215	4	of	of	IN
cord-002530-ao7kenbx	215	5	calcitonin	calcitonin	NN
cord-002530-ao7kenbx	215	6	peptide	peptide	NN
cord-002530-ao7kenbx	215	7	is	be	VBZ
cord-002530-ao7kenbx	215	8	also	also	RB
cord-002530-ao7kenbx	215	9	regulated	regulate	VBN
cord-002530-ao7kenbx	215	10	through	through	IN
cord-002530-ao7kenbx	215	11	differential	differential	JJ
cord-002530-ao7kenbx	215	12	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	215	13	of	of	IN
cord-002530-ao7kenbx	215	14	an	an	DT
cord-002530-ao7kenbx	215	15	embedded	embed	VBN
cord-002530-ao7kenbx	215	16	terminal	terminal	NN
cord-002530-ao7kenbx	215	17	exon	exon	NN
cord-002530-ao7kenbx	215	18	[	[	-LRB-
cord-002530-ao7kenbx	215	19	48	48	CD
cord-002530-ao7kenbx	215	20	]	]	-RRB-
cord-002530-ao7kenbx	215	21	.	.	.
cord-002530-ao7kenbx	216	1	Here	here	RB
cord-002530-ao7kenbx	216	2	,	,	,
cord-002530-ao7kenbx	216	3	the	the	DT
cord-002530-ao7kenbx	216	4	splicing	splicing	NN
cord-002530-ao7kenbx	216	5	factor	factor	NN
cord-002530-ao7kenbx	216	6	SRSF3	SRSF3	NNP
cord-002530-ao7kenbx	216	7	(	(	-LRB-
cord-002530-ao7kenbx	216	8	SRp20	SRp20	NNP
cord-002530-ao7kenbx	216	9	)	)	-RRB-
cord-002530-ao7kenbx	216	10	binds	bind	VBZ
cord-002530-ao7kenbx	216	11	to	to	IN
cord-002530-ao7kenbx	216	12	a	a	DT
cord-002530-ao7kenbx	216	13	polyA	polyA	NNP
cord-002530-ao7kenbx	216	14	enhancer	enhancer	NN
cord-002530-ao7kenbx	216	15	sequence	sequence	NN
cord-002530-ao7kenbx	216	16	and	and	CC
cord-002530-ao7kenbx	216	17	directs	direct	VBZ
cord-002530-ao7kenbx	216	18	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	216	19	of	of	IN
cord-002530-ao7kenbx	216	20	the	the	DT
cord-002530-ao7kenbx	216	21	upstream	upstream	JJ
cord-002530-ao7kenbx	216	22	polyA	polyA	NNP
cord-002530-ao7kenbx	216	23	site	site	NN
cord-002530-ao7kenbx	216	24	through	through	IN
cord-002530-ao7kenbx	216	25	recruitment	recruitment	NN
cord-002530-ao7kenbx	216	26	of	of	IN
cord-002530-ao7kenbx	216	27	polyA	polyA	NNP
cord-002530-ao7kenbx	216	28	factors	factor	NNS
cord-002530-ao7kenbx	216	29	.	.	.
cord-002530-ao7kenbx	217	1	Restricting	restrict	VBG
cord-002530-ao7kenbx	217	2	SRSF3	srsf3	NN
cord-002530-ao7kenbx	217	3	activity	activity	NN
cord-002530-ao7kenbx	217	4	results	result	NNS
cord-002530-ao7kenbx	217	5	in	in	IN
cord-002530-ao7kenbx	217	6	removal	removal	NN
cord-002530-ao7kenbx	217	7	of	of	IN
cord-002530-ao7kenbx	217	8	the	the	DT
cord-002530-ao7kenbx	217	9	upstream	upstream	JJ
cord-002530-ao7kenbx	217	10	terminal	terminal	NN
cord-002530-ao7kenbx	217	11	exon	exon	NN
cord-002530-ao7kenbx	217	12	by	by	IN
cord-002530-ao7kenbx	217	13	splicing	splice	VBG
cord-002530-ao7kenbx	217	14	and	and	CC
cord-002530-ao7kenbx	217	15	enhanced	enhanced	JJ
cord-002530-ao7kenbx	217	16	expression	expression	NN
cord-002530-ao7kenbx	217	17	of	of	IN
cord-002530-ao7kenbx	217	18	the	the	DT
cord-002530-ao7kenbx	217	19	downstream	downstream	JJ
cord-002530-ao7kenbx	217	20	terminal	terminal	NN
cord-002530-ao7kenbx	217	21	exon	exon	NN
cord-002530-ao7kenbx	217	22	.	.	.
cord-002530-ao7kenbx	218	1	In	in	IN
cord-002530-ao7kenbx	218	2	these	these	DT
cord-002530-ao7kenbx	218	3	examples	example	NNS
cord-002530-ao7kenbx	218	4	splicing	splicing	NN
cord-002530-ao7kenbx	218	5	is	be	VBZ
cord-002530-ao7kenbx	218	6	directly	directly	RB
cord-002530-ao7kenbx	218	7	linked	link	VBN
cord-002530-ao7kenbx	218	8	to	to	IN
cord-002530-ao7kenbx	218	9	cellular	cellular	JJ
cord-002530-ao7kenbx	218	10	differentiation	differentiation	NN
cord-002530-ao7kenbx	218	11	,	,	,
cord-002530-ao7kenbx	218	12	in	in	IN
cord-002530-ao7kenbx	218	13	the	the	DT
cord-002530-ao7kenbx	218	14	case	case	NN
cord-002530-ao7kenbx	218	15	of	of	IN
cord-002530-ao7kenbx	218	16	IgM	IgM	NNP
cord-002530-ao7kenbx	218	17	,	,	,
cord-002530-ao7kenbx	218	18	and	and	CC
cord-002530-ao7kenbx	218	19	tissue	tissue	NN
cord-002530-ao7kenbx	218	20	specificity	specificity	NN
cord-002530-ao7kenbx	218	21	,	,	,
cord-002530-ao7kenbx	218	22	in	in	IN
cord-002530-ao7kenbx	218	23	the	the	DT
cord-002530-ao7kenbx	218	24	case	case	NN
cord-002530-ao7kenbx	218	25	of	of	IN
cord-002530-ao7kenbx	218	26	calcitonin	calcitonin	NN
cord-002530-ao7kenbx	218	27	.	.	.
cord-002530-ao7kenbx	219	1	These	these	DT
cord-002530-ao7kenbx	219	2	factors	factor	NNS
cord-002530-ao7kenbx	219	3	are	be	VBP
cord-002530-ao7kenbx	219	4	fundamental	fundamental	JJ
cord-002530-ao7kenbx	219	5	to	to	IN
cord-002530-ao7kenbx	219	6	the	the	DT
cord-002530-ao7kenbx	219	7	regulation	regulation	NN
cord-002530-ao7kenbx	219	8	of	of	IN
cord-002530-ao7kenbx	219	9	HCMV	HCMV	NNP
cord-002530-ao7kenbx	219	10	latency	latency	NN
cord-002530-ao7kenbx	219	11	with	with	IN
cord-002530-ao7kenbx	219	12	cell	cell	NN
cord-002530-ao7kenbx	219	13	type	type	NN
cord-002530-ao7kenbx	219	14	specificity	specificity	NN
cord-002530-ao7kenbx	219	15	determining	determine	VBG
cord-002530-ao7kenbx	219	16	the	the	DT
cord-002530-ao7kenbx	219	17	site	site	NN
cord-002530-ao7kenbx	219	18	of	of	IN
cord-002530-ao7kenbx	219	19	latency	latency	NN
cord-002530-ao7kenbx	219	20	and	and	CC
cord-002530-ao7kenbx	219	21	differentiation	differentiation	NN
cord-002530-ao7kenbx	219	22	of	of	IN
cord-002530-ao7kenbx	219	23	latently	latently	RB
cord-002530-ao7kenbx	219	24	infected	infect	VBN
cord-002530-ao7kenbx	219	25	cells	cell	NNS
cord-002530-ao7kenbx	219	26	linked	link	VBN
cord-002530-ao7kenbx	219	27	to	to	IN
cord-002530-ao7kenbx	219	28	reactivation	reactivation	NN
cord-002530-ao7kenbx	219	29	[	[	-LRB-
cord-002530-ao7kenbx	219	30	13	13	CD
cord-002530-ao7kenbx	219	31	,	,	,
cord-002530-ao7kenbx	219	32	14	14	CD
cord-002530-ao7kenbx	219	33	]	]	-RRB-
cord-002530-ao7kenbx	219	34	.	.	.
cord-002530-ao7kenbx	220	1	Given	give	VBN
cord-002530-ao7kenbx	220	2	the	the	DT
cord-002530-ao7kenbx	220	3	central	central	JJ
cord-002530-ao7kenbx	220	4	role	role	NN
cord-002530-ao7kenbx	220	5	of	of	IN
cord-002530-ao7kenbx	220	6	IE2	ie2	NN
cord-002530-ao7kenbx	220	7	in	in	IN
cord-002530-ao7kenbx	220	8	determining	determine	VBG
cord-002530-ao7kenbx	220	9	virus	virus	NN
cord-002530-ao7kenbx	220	10	replication	replication	NN
cord-002530-ao7kenbx	220	11	,	,	,
cord-002530-ao7kenbx	220	12	linking	link	VBG
cord-002530-ao7kenbx	220	13	regulation	regulation	NN
cord-002530-ao7kenbx	220	14	of	of	IN
cord-002530-ao7kenbx	220	15	MIE	MIE	NNP
cord-002530-ao7kenbx	220	16	splicing	splice	VBG
cord-002530-ao7kenbx	220	17	to	to	IN
cord-002530-ao7kenbx	220	18	cellular	cellular	JJ
cord-002530-ao7kenbx	220	19	differentiation	differentiation	NN
cord-002530-ao7kenbx	220	20	and	and	CC
cord-002530-ao7kenbx	220	21	tissue	tissue	NN
cord-002530-ao7kenbx	220	22	specificity	specificity	NN
cord-002530-ao7kenbx	220	23	would	would	MD
cord-002530-ao7kenbx	220	24	be	be	VB
cord-002530-ao7kenbx	220	25	a	a	DT
cord-002530-ao7kenbx	220	26	potent	potent	JJ
cord-002530-ao7kenbx	220	27	mechanism	mechanism	NN
cord-002530-ao7kenbx	220	28	of	of	IN
cord-002530-ao7kenbx	220	29	regulating	regulate	VBG
cord-002530-ao7kenbx	220	30	the	the	DT
cord-002530-ao7kenbx	220	31	establishment	establishment	NN
cord-002530-ao7kenbx	220	32	,	,	,
cord-002530-ao7kenbx	220	33	maintenance	maintenance	NN
cord-002530-ao7kenbx	220	34	and	and	CC
cord-002530-ao7kenbx	220	35	reactivation	reactivation	NN
cord-002530-ao7kenbx	220	36	of	of	IN
cord-002530-ao7kenbx	220	37	latency	latency	NN
cord-002530-ao7kenbx	220	38	in	in	IN
cord-002530-ao7kenbx	220	39	HCMV	HCMV	NNP
cord-002530-ao7kenbx	220	40	.	.	.
cord-002530-ao7kenbx	221	1	Experiments	experiment	NNS
cord-002530-ao7kenbx	221	2	are	be	VBP
cord-002530-ao7kenbx	221	3	currently	currently	RB
cord-002530-ao7kenbx	221	4	underway	underway	JJ
cord-002530-ao7kenbx	221	5	to	to	TO
cord-002530-ao7kenbx	221	6	determine	determine	VB
cord-002530-ao7kenbx	221	7	whether	whether	IN
cord-002530-ao7kenbx	221	8	regulation	regulation	NN
cord-002530-ao7kenbx	221	9	of	of	IN
cord-002530-ao7kenbx	221	10	MIE	MIE	NNP
cord-002530-ao7kenbx	221	11	splicing	splicing	NN
cord-002530-ao7kenbx	221	12	by	by	IN
cord-002530-ao7kenbx	221	13	VCP	VCP	NNP
cord-002530-ao7kenbx	221	14	follows	follow	VBZ
cord-002530-ao7kenbx	221	15	a	a	DT
cord-002530-ao7kenbx	221	16	similar	similar	JJ
cord-002530-ao7kenbx	221	17	paradigm	paradigm	NN
cord-002530-ao7kenbx	221	18	to	to	IN
cord-002530-ao7kenbx	221	19	cellular	cellular	JJ
cord-002530-ao7kenbx	221	20	examples	example	NNS
cord-002530-ao7kenbx	221	21	and	and	CC
cord-002530-ao7kenbx	221	22	whether	whether	IN
cord-002530-ao7kenbx	221	23	such	such	JJ
cord-002530-ao7kenbx	221	24	regulation	regulation	NN
cord-002530-ao7kenbx	221	25	is	be	VBZ
cord-002530-ao7kenbx	221	26	involved	involve	VBN
cord-002530-ao7kenbx	221	27	in	in	IN
cord-002530-ao7kenbx	221	28	HCMV	HCMV	NNP
cord-002530-ao7kenbx	221	29	latency	latency	NN
cord-002530-ao7kenbx	221	30	.	.	.
cord-002530-ao7kenbx	222	1	Finally	finally	RB
cord-002530-ao7kenbx	222	2	,	,	,
cord-002530-ao7kenbx	222	3	as	as	IN
cord-002530-ao7kenbx	222	4	VCP	VCP	NNP
cord-002530-ao7kenbx	222	5	is	be	VBZ
cord-002530-ao7kenbx	222	6	clearly	clearly	RB
cord-002530-ao7kenbx	222	7	essential	essential	JJ
cord-002530-ao7kenbx	222	8	for	for	IN
cord-002530-ao7kenbx	222	9	virus	virus	NN
cord-002530-ao7kenbx	222	10	replication	replication	NN
cord-002530-ao7kenbx	222	11	,	,	,
cord-002530-ao7kenbx	222	12	small	small	JJ
cord-002530-ao7kenbx	222	13	molecule	molecule	NN
cord-002530-ao7kenbx	222	14	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	222	15	of	of	IN
cord-002530-ao7kenbx	222	16	VCP	VCP	NNP
cord-002530-ao7kenbx	222	17	are	be	VBP
cord-002530-ao7kenbx	222	18	potentially	potentially	RB
cord-002530-ao7kenbx	222	19	attractive	attractive	JJ
cord-002530-ao7kenbx	222	20	antiviral	antiviral	JJ
cord-002530-ao7kenbx	222	21	candidates	candidate	NNS
cord-002530-ao7kenbx	222	22	.	.	.
cord-002530-ao7kenbx	223	1	HCMV	HCMV	NNP
cord-002530-ao7kenbx	223	2	-	-	HYPH
cord-002530-ao7kenbx	223	3	related	relate	VBN
cord-002530-ao7kenbx	223	4	illness	illness	NN
cord-002530-ao7kenbx	223	5	accounts	account	VBZ
cord-002530-ao7kenbx	223	6	for	for	IN
cord-002530-ao7kenbx	223	7	more	more	JJR
cord-002530-ao7kenbx	223	8	than	than	IN
cord-002530-ao7kenbx	223	9	60	60	CD
cord-002530-ao7kenbx	223	10	%	%	NN
cord-002530-ao7kenbx	223	11	of	of	IN
cord-002530-ao7kenbx	223	12	diseases	disease	NNS
cord-002530-ao7kenbx	223	13	associated	associate	VBN
cord-002530-ao7kenbx	223	14	with	with	IN
cord-002530-ao7kenbx	223	15	solid	solid	JJ
cord-002530-ao7kenbx	223	16	organ	organ	NN
cord-002530-ao7kenbx	223	17	transplant	transplant	NN
cord-002530-ao7kenbx	223	18	patients	patient	NNS
cord-002530-ao7kenbx	223	19	.	.	.
cord-002530-ao7kenbx	224	1	Prolonged	prolonged	JJ
cord-002530-ao7kenbx	224	2	treatment	treatment	NN
cord-002530-ao7kenbx	224	3	,	,	,
cord-002530-ao7kenbx	224	4	especially	especially	RB
cord-002530-ao7kenbx	224	5	in	in	IN
cord-002530-ao7kenbx	224	6	patients	patient	NNS
cord-002530-ao7kenbx	224	7	with	with	IN
cord-002530-ao7kenbx	224	8	severely	severely	RB
cord-002530-ao7kenbx	224	9	suppressed	suppress	VBN
cord-002530-ao7kenbx	224	10	immune	immune	JJ
cord-002530-ao7kenbx	224	11	systems	system	NNS
cord-002530-ao7kenbx	224	12	,	,	,
cord-002530-ao7kenbx	224	13	greatly	greatly	RB
cord-002530-ao7kenbx	224	14	increases	increase	VBZ
cord-002530-ao7kenbx	224	15	the	the	DT
cord-002530-ao7kenbx	224	16	risk	risk	NN
cord-002530-ao7kenbx	224	17	of	of	IN
cord-002530-ao7kenbx	224	18	antiviral	antiviral	JJ
cord-002530-ao7kenbx	224	19	resistance	resistance	NN
cord-002530-ao7kenbx	224	20	[	[	-LRB-
cord-002530-ao7kenbx	224	21	49	49	CD
cord-002530-ao7kenbx	224	22	]	]	-RRB-
cord-002530-ao7kenbx	225	1	[	[	-LRB-
cord-002530-ao7kenbx	225	2	50	50	CD
cord-002530-ao7kenbx	225	3	]	]	-RRB-
cord-002530-ao7kenbx	225	4	[	[	-LRB-
cord-002530-ao7kenbx	225	5	51	51	CD
cord-002530-ao7kenbx	225	6	]	]	-RRB-
cord-002530-ao7kenbx	225	7	.	.	.
cord-002530-ao7kenbx	226	1	Very	very	RB
cord-002530-ao7kenbx	226	2	few	few	JJ
cord-002530-ao7kenbx	226	3	antivirals	antiviral	NNS
cord-002530-ao7kenbx	226	4	have	have	VBP
cord-002530-ao7kenbx	226	5	been	be	VBN
cord-002530-ao7kenbx	226	6	developed	develop	VBN
cord-002530-ao7kenbx	226	7	for	for	IN
cord-002530-ao7kenbx	226	8	use	use	NN
cord-002530-ao7kenbx	226	9	against	against	IN
cord-002530-ao7kenbx	226	10	HCMV	HCMV	NNP
cord-002530-ao7kenbx	226	11	since	since	IN
cord-002530-ao7kenbx	226	12	the	the	DT
cord-002530-ao7kenbx	226	13	licensing	licensing	NN
cord-002530-ao7kenbx	226	14	of	of	IN
cord-002530-ao7kenbx	226	15	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	226	16	,	,	,
cord-002530-ao7kenbx	226	17	and	and	CC
cord-002530-ao7kenbx	226	18	of	of	IN
cord-002530-ao7kenbx	226	19	these	these	DT
cord-002530-ao7kenbx	226	20	,	,	,
cord-002530-ao7kenbx	226	21	the	the	DT
cord-002530-ao7kenbx	226	22	same	same	JJ
cord-002530-ao7kenbx	226	23	viral	viral	JJ
cord-002530-ao7kenbx	226	24	genes	gene	NNS
cord-002530-ao7kenbx	226	25	are	be	VBP
cord-002530-ao7kenbx	226	26	targeted	target	VBN
cord-002530-ao7kenbx	226	27	,	,	,
cord-002530-ao7kenbx	226	28	reducing	reduce	VBG
cord-002530-ao7kenbx	226	29	the	the	DT
cord-002530-ao7kenbx	226	30	likely	likely	JJ
cord-002530-ao7kenbx	226	31	usefulness	usefulness	NN
cord-002530-ao7kenbx	226	32	of	of	IN
cord-002530-ao7kenbx	226	33	these	these	DT
cord-002530-ao7kenbx	226	34	drugs	drug	NNS
cord-002530-ao7kenbx	226	35	against	against	IN
cord-002530-ao7kenbx	226	36	resistant	resistant	JJ
cord-002530-ao7kenbx	226	37	strains	strain	NNS
cord-002530-ao7kenbx	226	38	[	[	-LRB-
cord-002530-ao7kenbx	226	39	52	52	CD
cord-002530-ao7kenbx	226	40	]	]	-RRB-
cord-002530-ao7kenbx	226	41	.	.	.
cord-002530-ao7kenbx	227	1	An	an	DT
cord-002530-ao7kenbx	227	2	alternative	alternative	JJ
cord-002530-ao7kenbx	227	3	strategy	strategy	NN
cord-002530-ao7kenbx	227	4	for	for	IN
cord-002530-ao7kenbx	227	5	the	the	DT
cord-002530-ao7kenbx	227	6	development	development	NN
cord-002530-ao7kenbx	227	7	of	of	IN
cord-002530-ao7kenbx	227	8	novel	novel	JJ
cord-002530-ao7kenbx	227	9	antivirals	antiviral	NNS
cord-002530-ao7kenbx	227	10	involves	involve	VBZ
cord-002530-ao7kenbx	227	11	targeting	target	VBG
cord-002530-ao7kenbx	227	12	of	of	IN
cord-002530-ao7kenbx	227	13	host	host	NN
cord-002530-ao7kenbx	227	14	genes	gene	NNS
cord-002530-ao7kenbx	227	15	required	require	VBN
cord-002530-ao7kenbx	227	16	by	by	IN
cord-002530-ao7kenbx	227	17	the	the	DT
cord-002530-ao7kenbx	227	18	virus	virus	NN
cord-002530-ao7kenbx	227	19	for	for	IN
cord-002530-ao7kenbx	227	20	successful	successful	JJ
cord-002530-ao7kenbx	227	21	replication	replication	NN
cord-002530-ao7kenbx	227	22	.	.	.
cord-002530-ao7kenbx	228	1	VCP	VCP	NNP
cord-002530-ao7kenbx	228	2	has	have	VBZ
cord-002530-ao7kenbx	228	3	been	be	VBN
cord-002530-ao7kenbx	228	4	identified	identify	VBN
cord-002530-ao7kenbx	228	5	as	as	IN
cord-002530-ao7kenbx	228	6	a	a	DT
cord-002530-ao7kenbx	228	7	potential	potential	JJ
cord-002530-ao7kenbx	228	8	anti	anti	JJ
cord-002530-ao7kenbx	228	9	-	-	JJ
cord-002530-ao7kenbx	228	10	cancer	cancer	JJ
cord-002530-ao7kenbx	228	11	target	target	NN
cord-002530-ao7kenbx	228	12	and	and	CC
cord-002530-ao7kenbx	228	13	as	as	RB
cord-002530-ao7kenbx	228	14	such	such	PDT
cord-002530-ao7kenbx	228	15	a	a	DT
cord-002530-ao7kenbx	228	16	number	number	NN
cord-002530-ao7kenbx	228	17	of	of	IN
cord-002530-ao7kenbx	228	18	small	small	JJ
cord-002530-ao7kenbx	228	19	molecule	molecule	NN
cord-002530-ao7kenbx	228	20	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	228	21	have	have	VBP
cord-002530-ao7kenbx	228	22	been	be	VBN
cord-002530-ao7kenbx	228	23	developed	develop	VBN
cord-002530-ao7kenbx	228	24	,	,	,
cord-002530-ao7kenbx	229	1	the	the	DT
cord-002530-ao7kenbx	229	2	most	most	RBS
cord-002530-ao7kenbx	229	3	potent	potent	JJ
cord-002530-ao7kenbx	229	4	of	of	IN
cord-002530-ao7kenbx	229	5	which	which	WDT
cord-002530-ao7kenbx	229	6	is	be	VBZ
cord-002530-ao7kenbx	229	7	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	229	8	[	[	-LRB-
cord-002530-ao7kenbx	229	9	36	36	CD
cord-002530-ao7kenbx	229	10	]	]	-RRB-
cord-002530-ao7kenbx	229	11	.	.	.
cord-002530-ao7kenbx	230	1	We	-PRON-	PRP
cord-002530-ao7kenbx	230	2	show	show	VBP
cord-002530-ao7kenbx	230	3	that	that	IN
cord-002530-ao7kenbx	230	4	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	230	5	is	be	VBZ
cord-002530-ao7kenbx	230	6	10	10	CD
cord-002530-ao7kenbx	230	7	times	time	NNS
cord-002530-ao7kenbx	230	8	more	more	RBR
cord-002530-ao7kenbx	230	9	potent	potent	JJ
cord-002530-ao7kenbx	230	10	than	than	IN
cord-002530-ao7kenbx	230	11	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	230	12	at	at	IN
cord-002530-ao7kenbx	230	13	equivalent	equivalent	JJ
cord-002530-ao7kenbx	230	14	concentrations	concentration	NNS
cord-002530-ao7kenbx	230	15	,	,	,
cord-002530-ao7kenbx	230	16	with	with	IN
cord-002530-ao7kenbx	230	17	little	little	JJ
cord-002530-ao7kenbx	230	18	sign	sign	NN
cord-002530-ao7kenbx	230	19	of	of	IN
cord-002530-ao7kenbx	230	20	toxicity	toxicity	NN
cord-002530-ao7kenbx	230	21	at	at	IN
cord-002530-ao7kenbx	230	22	active	active	JJ
cord-002530-ao7kenbx	230	23	levels	level	NNS
cord-002530-ao7kenbx	230	24	.	.	.
cord-002530-ao7kenbx	231	1	Whether	whether	IN
cord-002530-ao7kenbx	231	2	the	the	DT
cord-002530-ao7kenbx	231	3	drug	drug	NN
cord-002530-ao7kenbx	231	4	is	be	VBZ
cord-002530-ao7kenbx	231	5	toxic	toxic	JJ
cord-002530-ao7kenbx	231	6	in	in	IN
cord-002530-ao7kenbx	231	7	vivo	vivo	NN
cord-002530-ao7kenbx	231	8	remains	remain	VBZ
cord-002530-ao7kenbx	231	9	to	to	TO
cord-002530-ao7kenbx	231	10	be	be	VB
cord-002530-ao7kenbx	231	11	determined	determine	VBN
cord-002530-ao7kenbx	231	12	.	.	.
cord-002530-ao7kenbx	232	1	Deletion	deletion	NN
cord-002530-ao7kenbx	232	2	of	of	IN
cord-002530-ao7kenbx	232	3	VCP	VCP	NNP
cord-002530-ao7kenbx	232	4	in	in	IN
cord-002530-ao7kenbx	232	5	transgenic	transgenic	JJ
cord-002530-ao7kenbx	232	6	mice	mouse	NNS
cord-002530-ao7kenbx	232	7	is	be	VBZ
cord-002530-ao7kenbx	232	8	non	non	JJ
cord-002530-ao7kenbx	232	9	-	-	JJ
cord-002530-ao7kenbx	232	10	viable	viable	JJ
cord-002530-ao7kenbx	232	11	and	and	CC
cord-002530-ao7kenbx	232	12	naturally	naturally	RB
cord-002530-ao7kenbx	232	13	occurring	occur	VBG
cord-002530-ao7kenbx	232	14	mutations	mutation	NNS
cord-002530-ao7kenbx	232	15	in	in	IN
cord-002530-ao7kenbx	232	16	humans	human	NNS
cord-002530-ao7kenbx	232	17	are	be	VBP
cord-002530-ao7kenbx	232	18	linked	link	VBN
cord-002530-ao7kenbx	232	19	to	to	IN
cord-002530-ao7kenbx	232	20	severe	severe	JJ
cord-002530-ao7kenbx	232	21	developmental	developmental	JJ
cord-002530-ao7kenbx	232	22	defects	defect	NNS
cord-002530-ao7kenbx	232	23	[	[	-LRB-
cord-002530-ao7kenbx	232	24	21	21	CD
cord-002530-ao7kenbx	232	25	,	,	,
cord-002530-ao7kenbx	232	26	53	53	CD
cord-002530-ao7kenbx	232	27	]	]	-RRB-
cord-002530-ao7kenbx	232	28	.	.	.
cord-002530-ao7kenbx	233	1	However	however	RB
cord-002530-ao7kenbx	233	2	,	,	,
cord-002530-ao7kenbx	233	3	transient	transient	JJ
cord-002530-ao7kenbx	233	4	inhibition	inhibition	NN
cord-002530-ao7kenbx	233	5	of	of	IN
cord-002530-ao7kenbx	233	6	VCP	VCP	NNP
cord-002530-ao7kenbx	233	7	by	by	IN
cord-002530-ao7kenbx	233	8	small	small	JJ
cord-002530-ao7kenbx	233	9	molecule	molecule	NN
cord-002530-ao7kenbx	233	10	inhibitors	inhibitor	NNS
cord-002530-ao7kenbx	233	11	may	may	MD
cord-002530-ao7kenbx	233	12	be	be	VB
cord-002530-ao7kenbx	233	13	a	a	DT
cord-002530-ao7kenbx	233	14	viable	viable	JJ
cord-002530-ao7kenbx	233	15	treatment	treatment	NN
cord-002530-ao7kenbx	233	16	option	option	NN
cord-002530-ao7kenbx	233	17	,	,	,
cord-002530-ao7kenbx	233	18	especially	especially	RB
cord-002530-ao7kenbx	233	19	in	in	IN
cord-002530-ao7kenbx	233	20	patients	patient	NNS
cord-002530-ao7kenbx	233	21	where	where	WRB
cord-002530-ao7kenbx	233	22	resistance	resistance	NN
cord-002530-ao7kenbx	233	23	to	to	IN
cord-002530-ao7kenbx	233	24	current	current	JJ
cord-002530-ao7kenbx	233	25	antivirals	antiviral	NNS
cord-002530-ao7kenbx	233	26	poses	pose	VBZ
cord-002530-ao7kenbx	233	27	a	a	DT
cord-002530-ao7kenbx	233	28	significant	significant	JJ
cord-002530-ao7kenbx	233	29	risk	risk	NN
cord-002530-ao7kenbx	233	30	to	to	IN
cord-002530-ao7kenbx	233	31	health	health	NN
cord-002530-ao7kenbx	233	32	.	.	.
cord-002530-ao7kenbx	234	1	Normal	normal	JJ
cord-002530-ao7kenbx	234	2	Human	Human	NNP
cord-002530-ao7kenbx	234	3	Dermal	Dermal	NNP
cord-002530-ao7kenbx	234	4	Fibroblasts	Fibroblasts	NNPS
cord-002530-ao7kenbx	234	5	(	(	-LRB-
cord-002530-ao7kenbx	234	6	NHDF	NHDF	NNP
cord-002530-ao7kenbx	234	7	;	;	:
cord-002530-ao7kenbx	234	8	Gibco	Gibco	NNP
cord-002530-ao7kenbx	234	9	)	)	-RRB-
cord-002530-ao7kenbx	234	10	were	be	VBD
cord-002530-ao7kenbx	234	11	maintained	maintain	VBN
cord-002530-ao7kenbx	234	12	in	in	IN
cord-002530-ao7kenbx	234	13	Dulbecco	Dulbecco	NNP
cord-002530-ao7kenbx	234	14	's	's	POS
cord-002530-ao7kenbx	234	15	modified	modify	VBN
cord-002530-ao7kenbx	234	16	high	high	JJ
cord-002530-ao7kenbx	234	17	glucose	glucose	NN
cord-002530-ao7kenbx	234	18	media	medium	NNS
cord-002530-ao7kenbx	234	19	(	(	-LRB-
cord-002530-ao7kenbx	234	20	DMEM	DMEM	NNP
cord-002530-ao7kenbx	234	21	;	;	:
cord-002530-ao7kenbx	234	22	Sigma	Sigma	NNP
cord-002530-ao7kenbx	234	23	)	)	-RRB-
cord-002530-ao7kenbx	234	24	supplemented	supplement	VBD
cord-002530-ao7kenbx	234	25	with	with	IN
cord-002530-ao7kenbx	234	26	10	10	CD
cord-002530-ao7kenbx	234	27	%	%	NN
cord-002530-ao7kenbx	234	28	fetal	fetal	JJ
cord-002530-ao7kenbx	234	29	bovine	bovine	JJ
cord-002530-ao7kenbx	234	30	serum	serum	NN
cord-002530-ao7kenbx	234	31	(	(	-LRB-
cord-002530-ao7kenbx	234	32	FBS	FBS	NNP
cord-002530-ao7kenbx	234	33	;	;	:
cord-002530-ao7kenbx	234	34	Gibco	Gibco	NNP
cord-002530-ao7kenbx	234	35	)	)	-RRB-
cord-002530-ao7kenbx	234	36	and	and	CC
cord-002530-ao7kenbx	234	37	1	1	CD
cord-002530-ao7kenbx	234	38	%	%	NN
cord-002530-ao7kenbx	234	39	penicillin	penicillin	NN
cord-002530-ao7kenbx	234	40	-	-	HYPH
cord-002530-ao7kenbx	234	41	streptomycin	streptomycin	NNS
cord-002530-ao7kenbx	234	42	(	(	-LRB-
cord-002530-ao7kenbx	234	43	Invitrogen	Invitrogen	NNP
cord-002530-ao7kenbx	234	44	)	)	-RRB-
cord-002530-ao7kenbx	234	45	.	.	.
cord-002530-ao7kenbx	235	1	A	a	DT
cord-002530-ao7kenbx	235	2	low	low	JJ
cord-002530-ao7kenbx	235	3	passage	passage	NN
cord-002530-ao7kenbx	235	4	HCMV	HCMV	NNP
cord-002530-ao7kenbx	235	5	strain	strain	NN
cord-002530-ao7kenbx	235	6	TB40E	tb40e	NN
cord-002530-ao7kenbx	235	7	,	,	,
cord-002530-ao7kenbx	235	8	which	which	WDT
cord-002530-ao7kenbx	235	9	expresses	express	VBZ
cord-002530-ao7kenbx	235	10	GFP	GFP	NNP
cord-002530-ao7kenbx	235	11	from	from	IN
cord-002530-ao7kenbx	235	12	an	an	DT
cord-002530-ao7kenbx	235	13	SV40	SV40	NNP
cord-002530-ao7kenbx	235	14	promoter	promoter	NN
cord-002530-ao7kenbx	235	15	was	be	VBD
cord-002530-ao7kenbx	235	16	used	use	VBN
cord-002530-ao7kenbx	235	17	for	for	IN
cord-002530-ao7kenbx	235	18	siRNA	siRNA	NNP
cord-002530-ao7kenbx	235	19	library	library	NN
cord-002530-ao7kenbx	235	20	screening	screening	NN
cord-002530-ao7kenbx	235	21	,	,	,
cord-002530-ao7kenbx	235	22	western	western	JJ
cord-002530-ao7kenbx	235	23	blot	blot	NN
cord-002530-ao7kenbx	235	24	analysis	analysis	NN
cord-002530-ao7kenbx	235	25	,	,	,
cord-002530-ao7kenbx	235	26	and	and	CC
cord-002530-ao7kenbx	235	27	northern	northern	JJ
cord-002530-ao7kenbx	235	28	blot	blot	NN
cord-002530-ao7kenbx	235	29	analysis	analysis	NN
cord-002530-ao7kenbx	235	30	.	.	.
cord-002530-ao7kenbx	236	1	Laboratory	laboratory	NN
cord-002530-ao7kenbx	236	2	adapted	adapt	VBD
cord-002530-ao7kenbx	236	3	HCMV	HCMV	NNP
cord-002530-ao7kenbx	236	4	strain	strain	NN
cord-002530-ao7kenbx	236	5	AD169	AD169	NNP
cord-002530-ao7kenbx	236	6	was	be	VBD
cord-002530-ao7kenbx	236	7	used	use	VBN
cord-002530-ao7kenbx	236	8	for	for	IN
cord-002530-ao7kenbx	236	9	immunofluorescence	immunofluorescence	NN
cord-002530-ao7kenbx	236	10	experiments	experiment	NNS
cord-002530-ao7kenbx	236	11	.	.	.
cord-002530-ao7kenbx	237	1	The	the	DT
cord-002530-ao7kenbx	237	2	Human	Human	NNP
cord-002530-ao7kenbx	237	3	siGENOME	siGENOME	NNP
cord-002530-ao7kenbx	237	4	siRNA	siRNA	NNP
cord-002530-ao7kenbx	237	5	Library	Library	NNP
cord-002530-ao7kenbx	237	6	that	that	WDT
cord-002530-ao7kenbx	237	7	targets	target	VBZ
cord-002530-ao7kenbx	237	8	140	140	CD
cord-002530-ao7kenbx	237	9	membrane	membrane	NN
cord-002530-ao7kenbx	237	10	trafficking	trafficking	NN
cord-002530-ao7kenbx	237	11	genes	gene	NNS
cord-002530-ao7kenbx	237	12	(	(	-LRB-
cord-002530-ao7kenbx	237	13	4	4	CD
cord-002530-ao7kenbx	237	14	siR	siR	NNP
cord-002530-ao7kenbx	237	15	-	-	HYPH
cord-002530-ao7kenbx	237	16	NAs	na	NNS
cord-002530-ao7kenbx	237	17	per	per	IN
cord-002530-ao7kenbx	237	18	gene	gene	NN
cord-002530-ao7kenbx	237	19	;	;	:
cord-002530-ao7kenbx	237	20	Dharmacon	Dharmacon	NNP
cord-002530-ao7kenbx	237	21	,	,	,
cord-002530-ao7kenbx	237	22	Inc.	Inc.	NNP
cord-002530-ao7kenbx	237	23	)	)	-RRB-
cord-002530-ao7kenbx	237	24	and	and	CC
cord-002530-ao7kenbx	237	25	20	20	CD
cord-002530-ao7kenbx	237	26	other	other	JJ
cord-002530-ao7kenbx	237	27	selected	select	VBN
cord-002530-ao7kenbx	237	28	genes	gene	NNS
cord-002530-ao7kenbx	237	29	were	be	VBD
cord-002530-ao7kenbx	237	30	included	include	VBN
cord-002530-ao7kenbx	237	31	in	in	IN
cord-002530-ao7kenbx	237	32	the	the	DT
cord-002530-ao7kenbx	237	33	primary	primary	JJ
cord-002530-ao7kenbx	237	34	screen	screen	NN
cord-002530-ao7kenbx	237	35	.	.	.
cord-002530-ao7kenbx	238	1	In	in	IN
cord-002530-ao7kenbx	238	2	brief	brief	NN
cord-002530-ao7kenbx	238	3	,	,	,
cord-002530-ao7kenbx	238	4	NHDFs	NHDFs	NNPS
cord-002530-ao7kenbx	238	5	were	be	VBD
cord-002530-ao7kenbx	238	6	seeded	seed	VBN
cord-002530-ao7kenbx	238	7	in	in	IN
cord-002530-ao7kenbx	238	8	96-well	96-well	CD
cord-002530-ao7kenbx	238	9	plate	plate	NN
cord-002530-ao7kenbx	238	10	a	a	DT
cord-002530-ao7kenbx	238	11	day	day	NN
cord-002530-ao7kenbx	238	12	before	before	IN
cord-002530-ao7kenbx	238	13	siRNA	siRNA	NNP
cord-002530-ao7kenbx	238	14	transfection	transfection	NN
cord-002530-ao7kenbx	238	15	.	.	.
cord-002530-ao7kenbx	239	1	Next	next	JJ
cord-002530-ao7kenbx	239	2	day	day	NN
cord-002530-ao7kenbx	239	3	,	,	,
cord-002530-ao7kenbx	239	4	cells	cell	NNS
cord-002530-ao7kenbx	239	5	reached	reach	VBD
cord-002530-ao7kenbx	239	6	90	90	CD
cord-002530-ao7kenbx	239	7	-	-	SYM
cord-002530-ao7kenbx	239	8	95	95	CD
cord-002530-ao7kenbx	239	9	%	%	NN
cord-002530-ao7kenbx	239	10	confluency	confluency	NN
cord-002530-ao7kenbx	239	11	and	and	CC
cord-002530-ao7kenbx	239	12	were	be	VBD
cord-002530-ao7kenbx	239	13	transfected	transfecte	VBN
cord-002530-ao7kenbx	239	14	with	with	IN
cord-002530-ao7kenbx	239	15	siRNA	siRNA	NNP
cord-002530-ao7kenbx	239	16	twice	twice	PDT
cord-002530-ao7kenbx	239	17	(	(	-LRB-
cord-002530-ao7kenbx	239	18	4	4	CD
cord-002530-ao7kenbx	239	19	hours	hour	NNS
cord-002530-ao7kenbx	239	20	apart	apart	RB
cord-002530-ao7kenbx	239	21	between	between	IN
cord-002530-ao7kenbx	239	22	first	first	JJ
cord-002530-ao7kenbx	239	23	and	and	CC
cord-002530-ao7kenbx	239	24	second	second	JJ
cord-002530-ao7kenbx	239	25	transfections	transfection	NNS
cord-002530-ao7kenbx	239	26	)	)	-RRB-
cord-002530-ao7kenbx	239	27	using	use	VBG
cord-002530-ao7kenbx	239	28	Lipofectamine	Lipofectamine	NNP
cord-002530-ao7kenbx	239	29	RNAiMAX	RNAiMAX	NNP
cord-002530-ao7kenbx	239	30	(	(	-LRB-
cord-002530-ao7kenbx	239	31	Invitrogen	Invitrogen	NNP
cord-002530-ao7kenbx	239	32	)	)	-RRB-
cord-002530-ao7kenbx	239	33	according	accord	VBG
cord-002530-ao7kenbx	239	34	to	to	IN
cord-002530-ao7kenbx	239	35	the	the	DT
cord-002530-ao7kenbx	239	36	manufacturer	manufacturer	NN
cord-002530-ao7kenbx	239	37	's	's	POS
cord-002530-ao7kenbx	239	38	protocol	protocol	NN
cord-002530-ao7kenbx	239	39	.	.	.
cord-002530-ao7kenbx	240	1	Transfected	Transfected	NNP
cord-002530-ao7kenbx	240	2	NHDFs	NHDFs	NNPS
cord-002530-ao7kenbx	240	3	were	be	VBD
cord-002530-ao7kenbx	240	4	incubated	incubate	VBN
cord-002530-ao7kenbx	240	5	for	for	IN
cord-002530-ao7kenbx	240	6	48	48	CD
cord-002530-ao7kenbx	240	7	hours	hour	NNS
cord-002530-ao7kenbx	240	8	and	and	CC
cord-002530-ao7kenbx	240	9	then	then	RB
cord-002530-ao7kenbx	240	10	infected	infect	VBN
cord-002530-ao7kenbx	240	11	with	with	IN
cord-002530-ao7kenbx	240	12	GFP	GFP	NNP
cord-002530-ao7kenbx	240	13	expressing	express	VBG
cord-002530-ao7kenbx	240	14	TB40E	tb40e	NN
cord-002530-ao7kenbx	240	15	virus	virus	NN
cord-002530-ao7kenbx	240	16	at	at	IN
cord-002530-ao7kenbx	240	17	an	an	DT
cord-002530-ao7kenbx	240	18	MOI	MOI	NNP
cord-002530-ao7kenbx	240	19	of	of	IN
cord-002530-ao7kenbx	240	20	three	three	CD
cord-002530-ao7kenbx	240	21	.	.	.
cord-002530-ao7kenbx	241	1	GFP	GFP	NNP
cord-002530-ao7kenbx	241	2	intensity	intensity	NN
cord-002530-ao7kenbx	241	3	was	be	VBD
cord-002530-ao7kenbx	241	4	monitored	monitor	VBN
cord-002530-ao7kenbx	241	5	every	every	DT
cord-002530-ao7kenbx	241	6	24	24	CD
cord-002530-ao7kenbx	241	7	hours	hour	NNS
cord-002530-ao7kenbx	241	8	with	with	IN
cord-002530-ao7kenbx	241	9	Synergy	Synergy	NNP
cord-002530-ao7kenbx	241	10	HT	HT	NNP
cord-002530-ao7kenbx	241	11	microplate	microplate	NN
cord-002530-ao7kenbx	241	12	reader	reader	NN
cord-002530-ao7kenbx	241	13	(	(	-LRB-
cord-002530-ao7kenbx	241	14	Biotek	Biotek	NNP
cord-002530-ao7kenbx	241	15	)	)	-RRB-
cord-002530-ao7kenbx	241	16	.	.	.
cord-002530-ao7kenbx	242	1	The	the	DT
cord-002530-ao7kenbx	242	2	entire	entire	JJ
cord-002530-ao7kenbx	242	3	screen	screen	NN
cord-002530-ao7kenbx	242	4	was	be	VBD
cord-002530-ao7kenbx	242	5	performed	perform	VBN
cord-002530-ao7kenbx	242	6	in	in	IN
cord-002530-ao7kenbx	242	7	duplicate	duplicate	NN
cord-002530-ao7kenbx	242	8	and	and	CC
cord-002530-ao7kenbx	242	9	repeated	repeat	VBD
cord-002530-ao7kenbx	242	10	three	three	CD
cord-002530-ao7kenbx	242	11	times	time	NNS
cord-002530-ao7kenbx	242	12	.	.	.
cord-002530-ao7kenbx	243	1	VCP	VCP	NNP
cord-002530-ao7kenbx	243	2	gene	gene	NN
cord-002530-ao7kenbx	243	3	identified	identify	VBN
cord-002530-ao7kenbx	243	4	from	from	IN
cord-002530-ao7kenbx	243	5	the	the	DT
cord-002530-ao7kenbx	243	6	primary	primary	JJ
cord-002530-ao7kenbx	243	7	screen	screen	NN
cord-002530-ao7kenbx	243	8	was	be	VBD
cord-002530-ao7kenbx	243	9	subsequently	subsequently	RB
cord-002530-ao7kenbx	243	10	silenced	silence	VBN
cord-002530-ao7kenbx	243	11	with	with	IN
cord-002530-ao7kenbx	243	12	four	four	CD
cord-002530-ao7kenbx	243	13	individual	individual	JJ
cord-002530-ao7kenbx	243	14	siRNAs	siRNAs	NNP
cord-002530-ao7kenbx	243	15	to	to	TO
cord-002530-ao7kenbx	243	16	eliminate	eliminate	VB
cord-002530-ao7kenbx	243	17	the	the	DT
cord-002530-ao7kenbx	243	18	possibility	possibility	NN
cord-002530-ao7kenbx	243	19	that	that	IN
cord-002530-ao7kenbx	243	20	the	the	DT
cord-002530-ao7kenbx	243	21	phenotype	phenotype	NN
cord-002530-ao7kenbx	243	22	was	be	VBD
cord-002530-ao7kenbx	243	23	associated	associate	VBN
cord-002530-ao7kenbx	243	24	with	with	IN
cord-002530-ao7kenbx	243	25	off	off	JJ
cord-002530-ao7kenbx	243	26	target	target	NN
cord-002530-ao7kenbx	243	27	effects	effect	NNS
cord-002530-ao7kenbx	243	28	.	.	.
cord-002530-ao7kenbx	244	1	Cells	cell	NNS
cord-002530-ao7kenbx	244	2	were	be	VBD
cord-002530-ao7kenbx	244	3	lysed	lyse	VBN
cord-002530-ao7kenbx	244	4	with	with	IN
cord-002530-ao7kenbx	244	5	RIPA	RIPA	NNP
cord-002530-ao7kenbx	244	6	buffer	buffer	NN
cord-002530-ao7kenbx	244	7	(	(	-LRB-
cord-002530-ao7kenbx	244	8	0.1	0.1	CD
cord-002530-ao7kenbx	244	9	%	%	NN
cord-002530-ao7kenbx	244	10	SDS	SDS	NNP
cord-002530-ao7kenbx	244	11	,	,	,
cord-002530-ao7kenbx	244	12	1	1	CD
cord-002530-ao7kenbx	244	13	%	%	NN
cord-002530-ao7kenbx	244	14	Triton	Triton	NNP
cord-002530-ao7kenbx	244	15	X-100	x-100	NN
cord-002530-ao7kenbx	244	16	,	,	,
cord-002530-ao7kenbx	244	17	1	1	CD
cord-002530-ao7kenbx	244	18	%	%	NN
cord-002530-ao7kenbx	244	19	deoxycholate	deoxycholate	NN
cord-002530-ao7kenbx	244	20	,	,	,
cord-002530-ao7kenbx	245	1	5	5	LS
cord-002530-ao7kenbx	245	2	mM	mm	CD
cord-002530-ao7kenbx	245	3	EDTA	EDTA	NNP
cord-002530-ao7kenbx	245	4	,	,	,
cord-002530-ao7kenbx	245	5	150	150	CD
cord-002530-ao7kenbx	245	6	mM	mm	CD
cord-002530-ao7kenbx	245	7	NaCl	nacl	NN
cord-002530-ao7kenbx	245	8	,	,	,
cord-002530-ao7kenbx	245	9	and	and	CC
cord-002530-ao7kenbx	245	10	10	10	CD
cord-002530-ao7kenbx	245	11	mM	mm	CD
cord-002530-ao7kenbx	245	12	Tris	Tris	NNP
cord-002530-ao7kenbx	245	13	at	at	IN
cord-002530-ao7kenbx	245	14	pH	pH	NNP
cord-002530-ao7kenbx	245	15	7.2	7.2	CD
cord-002530-ao7kenbx	245	16	)	)	-RRB-
cord-002530-ao7kenbx	245	17	containing	contain	VBG
cord-002530-ao7kenbx	245	18	protease	protease	NN
cord-002530-ao7kenbx	245	19	inhibitor	inhibitor	NN
cord-002530-ao7kenbx	245	20	cocktail	cocktail	NN
cord-002530-ao7kenbx	245	21	(	(	-LRB-
cord-002530-ao7kenbx	245	22	Roche	Roche	NNP
cord-002530-ao7kenbx	245	23	)	)	-RRB-
cord-002530-ao7kenbx	245	24	.	.	.
cord-002530-ao7kenbx	246	1	Ten	ten	CD
cord-002530-ao7kenbx	246	2	micrograms	microgram	NNS
cord-002530-ao7kenbx	246	3	of	of	IN
cord-002530-ao7kenbx	246	4	the	the	DT
cord-002530-ao7kenbx	246	5	total	total	JJ
cord-002530-ao7kenbx	246	6	lysate	lysate	NN
cord-002530-ao7kenbx	246	7	was	be	VBD
cord-002530-ao7kenbx	246	8	separated	separate	VBN
cord-002530-ao7kenbx	246	9	in	in	IN
cord-002530-ao7kenbx	246	10	10	10	CD
cord-002530-ao7kenbx	246	11	%	%	NN
cord-002530-ao7kenbx	246	12	SDS	sds	NN
cord-002530-ao7kenbx	246	13	-	-	HYPH
cord-002530-ao7kenbx	246	14	polyacrylamide	polyacrylamide	NN
cord-002530-ao7kenbx	246	15	gels	gel	NNS
cord-002530-ao7kenbx	246	16	and	and	CC
cord-002530-ao7kenbx	246	17	transferred	transfer	VBN
cord-002530-ao7kenbx	246	18	to	to	IN
cord-002530-ao7kenbx	246	19	PVDF	pvdf	NN
cord-002530-ao7kenbx	246	20	membranes	membrane	NNS
cord-002530-ao7kenbx	246	21	(	(	-LRB-
cord-002530-ao7kenbx	246	22	Millipore	Millipore	NNP
cord-002530-ao7kenbx	246	23	)	)	-RRB-
cord-002530-ao7kenbx	246	24	.	.	.
cord-002530-ao7kenbx	247	1	Primary	primary	JJ
cord-002530-ao7kenbx	247	2	antibodies	antibody	NNS
cord-002530-ao7kenbx	247	3	used	use	VBN
cord-002530-ao7kenbx	247	4	in	in	IN
cord-002530-ao7kenbx	247	5	this	this	DT
cord-002530-ao7kenbx	247	6	paper	paper	NN
cord-002530-ao7kenbx	247	7	are	be	VBP
cord-002530-ao7kenbx	247	8	mouse	mouse	NN
cord-002530-ao7kenbx	247	9	anti	anti	JJ
cord-002530-ao7kenbx	247	10	-	-	JJ
cord-002530-ao7kenbx	247	11	CMV	cmv	JJ
cord-002530-ao7kenbx	247	12	IE1/2	ie1/2	NN
cord-002530-ao7kenbx	247	13	monoclonal	monoclonal	JJ
cord-002530-ao7kenbx	247	14	antibody	antibody	NN
cord-002530-ao7kenbx	247	15	(	(	-LRB-
cord-002530-ao7kenbx	247	16	MAB8131	MAB8131	NNP
cord-002530-ao7kenbx	247	17	,	,	,
cord-002530-ao7kenbx	247	18	Millipore	Millipore	NNP
cord-002530-ao7kenbx	247	19	)	)	-RRB-
cord-002530-ao7kenbx	247	20	,	,	,
cord-002530-ao7kenbx	247	21	mouse	mouse	NN
cord-002530-ao7kenbx	247	22	anti	anti	JJ
cord-002530-ao7kenbx	247	23	-	-	JJ
cord-002530-ao7kenbx	247	24	CMV	CMV	NNP
cord-002530-ao7kenbx	247	25	pp52	pp52	NN
cord-002530-ao7kenbx	247	26	monoclonal	monoclonal	JJ
cord-002530-ao7kenbx	247	27	antibody	antibody	NN
cord-002530-ao7kenbx	247	28	(	(	-LRB-
cord-002530-ao7kenbx	247	29	CH16	CH16	NNP
cord-002530-ao7kenbx	247	30	,	,	,
cord-002530-ao7kenbx	247	31	Santa	Santa	NNP
cord-002530-ao7kenbx	247	32	Cruz	Cruz	NNP
cord-002530-ao7kenbx	247	33	Biotechnology	Biotechnology	NNP
cord-002530-ao7kenbx	247	34	)	)	-RRB-
cord-002530-ao7kenbx	247	35	,	,	,
cord-002530-ao7kenbx	247	36	mouse	mouse	NN
cord-002530-ao7kenbx	247	37	anti	anti	JJ
cord-002530-ao7kenbx	247	38	-	-	JJ
cord-002530-ao7kenbx	247	39	CMV	CMV	NNP
cord-002530-ao7kenbx	247	40	pp28	pp28	NN
cord-002530-ao7kenbx	247	41	monoclonal	monoclonal	JJ
cord-002530-ao7kenbx	247	42	antibody	antibody	NN
cord-002530-ao7kenbx	247	43	(	(	-LRB-
cord-002530-ao7kenbx	247	44	CH19	CH19	NNP
cord-002530-ao7kenbx	247	45	,	,	,
cord-002530-ao7kenbx	247	46	Santa	Santa	NNP
cord-002530-ao7kenbx	247	47	Cruz	Cruz	NNP
cord-002530-ao7kenbx	247	48	Biotechnology	Biotechnology	NNP
cord-002530-ao7kenbx	247	49	)	)	-RRB-
cord-002530-ao7kenbx	247	50	,	,	,
cord-002530-ao7kenbx	247	51	rabbit	rabbit	NN
cord-002530-ao7kenbx	247	52	anti	anti	JJ
cord-002530-ao7kenbx	247	53	-	-	JJ
cord-002530-ao7kenbx	247	54	VCP	vcp	JJ
cord-002530-ao7kenbx	247	55	polyclonal	polyclonal	JJ
cord-002530-ao7kenbx	247	56	antibody	antibody	NN
cord-002530-ao7kenbx	247	57	(	(	-LRB-
cord-002530-ao7kenbx	247	58	H-120	h-120	RB
cord-002530-ao7kenbx	247	59	,	,	,
cord-002530-ao7kenbx	247	60	Santa	Santa	NNP
cord-002530-ao7kenbx	247	61	Cruz	Cruz	NNP
cord-002530-ao7kenbx	247	62	Biotechnology	Biotechnology	NNP
cord-002530-ao7kenbx	247	63	)	)	-RRB-
cord-002530-ao7kenbx	247	64	,	,	,
cord-002530-ao7kenbx	247	65	and	and	CC
cord-002530-ao7kenbx	247	66	mouse	mouse	NN
cord-002530-ao7kenbx	247	67	anti	anti	NNP
cord-002530-ao7kenbx	247	68	-	-	JJ
cord-002530-ao7kenbx	247	69	β	β	JJ
cord-002530-ao7kenbx	247	70	-	-	HYPH
cord-002530-ao7kenbx	247	71	Actin	Actin	NNP
cord-002530-ao7kenbx	247	72	monoclonal	monoclonal	JJ
cord-002530-ao7kenbx	247	73	antibody	antibody	NN
cord-002530-ao7kenbx	247	74	(	(	-LRB-
cord-002530-ao7kenbx	247	75	Abcam	Abcam	NNP
cord-002530-ao7kenbx	247	76	)	)	-RRB-
cord-002530-ao7kenbx	247	77	.	.	.
cord-002530-ao7kenbx	248	1	Blots	blot	NNS
cord-002530-ao7kenbx	248	2	were	be	VBD
cord-002530-ao7kenbx	248	3	probed	probe	VBN
cord-002530-ao7kenbx	248	4	with	with	IN
cord-002530-ao7kenbx	248	5	primary	primary	JJ
cord-002530-ao7kenbx	248	6	antibody	antibody	NN
cord-002530-ao7kenbx	248	7	(	(	-LRB-
cord-002530-ao7kenbx	248	8	1:500	1:500	CD
cord-002530-ao7kenbx	248	9	-	-	SYM
cord-002530-ao7kenbx	248	10	1:2000	1:2000	CD
cord-002530-ao7kenbx	248	11	)	)	-RRB-
cord-002530-ao7kenbx	248	12	diluted	dilute	VBN
cord-002530-ao7kenbx	248	13	in	in	IN
cord-002530-ao7kenbx	248	14	5	5	CD
cord-002530-ao7kenbx	248	15	%	%	NN
cord-002530-ao7kenbx	248	16	dehydrated	dehydrated	JJ
cord-002530-ao7kenbx	248	17	milk	milk	NN
cord-002530-ao7kenbx	248	18	in	in	IN
cord-002530-ao7kenbx	248	19	Tris	Tris	NNP
cord-002530-ao7kenbx	248	20	Buffered	Buffered	NNP
cord-002530-ao7kenbx	248	21	Saline	Saline	NNP
cord-002530-ao7kenbx	248	22	(	(	-LRB-
cord-002530-ao7kenbx	248	23	TBS	TBS	NNP
cord-002530-ao7kenbx	248	24	)	)	-RRB-
cord-002530-ao7kenbx	248	25	and	and	CC
cord-002530-ao7kenbx	248	26	subsequently	subsequently	RB
cord-002530-ao7kenbx	248	27	the	the	DT
cord-002530-ao7kenbx	248	28	HRP	HRP	NNP
cord-002530-ao7kenbx	248	29	-	-	HYPH
cord-002530-ao7kenbx	248	30	conjugated	conjugate	VBN
cord-002530-ao7kenbx	248	31	secondary	secondary	JJ
cord-002530-ao7kenbx	248	32	antibodies	antibody	NNS
cord-002530-ao7kenbx	248	33	(	(	-LRB-
cord-002530-ao7kenbx	248	34	Pierce	Pierce	NNP
cord-002530-ao7kenbx	248	35	)	)	-RRB-
cord-002530-ao7kenbx	248	36	at	at	IN
cord-002530-ao7kenbx	248	37	1:5000	1:5000	NNS
cord-002530-ao7kenbx	248	38	.	.	.
cord-002530-ao7kenbx	249	1	Blots	blot	NNS
cord-002530-ao7kenbx	249	2	were	be	VBD
cord-002530-ao7kenbx	249	3	washed	wash	VBN
cord-002530-ao7kenbx	249	4	in	in	IN
cord-002530-ao7kenbx	249	5	TBS	TBS	NNP
cord-002530-ao7kenbx	249	6	three	three	CD
cord-002530-ao7kenbx	249	7	times	time	NNS
cord-002530-ao7kenbx	249	8	,	,	,
cord-002530-ao7kenbx	249	9	incubated	incubate	VBN
cord-002530-ao7kenbx	249	10	with	with	IN
cord-002530-ao7kenbx	249	11	chemiluminescent	chemiluminescent	NN
cord-002530-ao7kenbx	249	12	substrate	substrate	NN
cord-002530-ao7kenbx	249	13	(	(	-LRB-
cord-002530-ao7kenbx	249	14	SuperSignal	SuperSignal	NNP
cord-002530-ao7kenbx	249	15	West	West	NNP
cord-002530-ao7kenbx	249	16	Pico	Pico	NNP
cord-002530-ao7kenbx	249	17	;	;	:
cord-002530-ao7kenbx	249	18	Thermo	Thermo	NNP
cord-002530-ao7kenbx	249	19	Scientific	Scientific	NNP
cord-002530-ao7kenbx	249	20	)	)	-RRB-
cord-002530-ao7kenbx	249	21	according	accord	VBG
cord-002530-ao7kenbx	249	22	to	to	IN
cord-002530-ao7kenbx	249	23	the	the	DT
cord-002530-ao7kenbx	249	24	manufacturer	manufacturer	NN
cord-002530-ao7kenbx	249	25	's	's	POS
cord-002530-ao7kenbx	249	26	protocol	protocol	NN
cord-002530-ao7kenbx	249	27	,	,	,
cord-002530-ao7kenbx	249	28	and	and	CC
cord-002530-ao7kenbx	249	29	exposed	expose	VBN
cord-002530-ao7kenbx	249	30	in	in	IN
cord-002530-ao7kenbx	249	31	G	g	NN
cord-002530-ao7kenbx	249	32	:	:	:
cord-002530-ao7kenbx	249	33	Box	Box	NNP
cord-002530-ao7kenbx	249	34	(	(	-LRB-
cord-002530-ao7kenbx	249	35	Syngene	Syngene	NNP
cord-002530-ao7kenbx	249	36	)	)	-RRB-
cord-002530-ao7kenbx	249	37	for	for	IN
cord-002530-ao7kenbx	249	38	visualization	visualization	NN
cord-002530-ao7kenbx	249	39	of	of	IN
cord-002530-ao7kenbx	249	40	bands	band	NNS
cord-002530-ao7kenbx	249	41	.	.	.
cord-002530-ao7kenbx	250	1	Total	Total	NNP
cord-002530-ao7kenbx	250	2	RNA	RNA	NNP
cord-002530-ao7kenbx	250	3	was	be	VBD
cord-002530-ao7kenbx	250	4	isolated	isolate	VBN
cord-002530-ao7kenbx	250	5	by	by	IN
cord-002530-ao7kenbx	250	6	using	use	VBG
cord-002530-ao7kenbx	250	7	Trizol	Trizol	NNP
cord-002530-ao7kenbx	250	8	solution	solution	NN
cord-002530-ao7kenbx	250	9	according	accord	VBG
cord-002530-ao7kenbx	250	10	to	to	IN
cord-002530-ao7kenbx	250	11	the	the	DT
cord-002530-ao7kenbx	250	12	manufacturer	manufacturer	NN
cord-002530-ao7kenbx	250	13	's	's	POS
cord-002530-ao7kenbx	250	14	protocol	protocol	NN
cord-002530-ao7kenbx	250	15	.	.	.
cord-002530-ao7kenbx	251	1	Northern	northern	JJ
cord-002530-ao7kenbx	251	2	blot	blot	NN
cord-002530-ao7kenbx	251	3	analysis	analysis	NN
cord-002530-ao7kenbx	251	4	for	for	IN
cord-002530-ao7kenbx	251	5	IE1	ie1	NN
cord-002530-ao7kenbx	251	6	and	and	CC
cord-002530-ao7kenbx	251	7	IE2	IE2	NNP
cord-002530-ao7kenbx	252	1	mRNAs	mRNAs	NNP
cord-002530-ao7kenbx	252	2	was	be	VBD
cord-002530-ao7kenbx	252	3	conducted	conduct	VBN
cord-002530-ao7kenbx	252	4	using	use	VBG
cord-002530-ao7kenbx	252	5	total	total	JJ
cord-002530-ao7kenbx	252	6	RNA	RNA	NNP
cord-002530-ao7kenbx	252	7	that	that	WDT
cord-002530-ao7kenbx	252	8	was	be	VBD
cord-002530-ao7kenbx	252	9	separated	separate	VBN
cord-002530-ao7kenbx	252	10	on	on	IN
cord-002530-ao7kenbx	252	11	a	a	DT
cord-002530-ao7kenbx	252	12	1.2	1.2	CD
cord-002530-ao7kenbx	252	13	%	%	NN
cord-002530-ao7kenbx	252	14	agarose	agarose	JJ
cord-002530-ao7kenbx	252	15	formaldehyde	formaldehyde	NN
cord-002530-ao7kenbx	252	16	gel	gel	NN
cord-002530-ao7kenbx	252	17	and	and	CC
cord-002530-ao7kenbx	252	18	then	then	RB
cord-002530-ao7kenbx	252	19	transferred	transfer	VBD
cord-002530-ao7kenbx	252	20	using	use	VBG
cord-002530-ao7kenbx	252	21	Whatman	Whatman	NNP
cord-002530-ao7kenbx	252	22	TurboBlotter	TurboBlotter	NNP
cord-002530-ao7kenbx	252	23	Rapid	Rapid	NNP
cord-002530-ao7kenbx	252	24	Downward	Downward	NNP
cord-002530-ao7kenbx	252	25	Transfer	Transfer	NNP
cord-002530-ao7kenbx	252	26	Systems	Systems	NNPS
cord-002530-ao7kenbx	252	27	.	.	.
cord-002530-ao7kenbx	253	1	IE1	ie1	NN
cord-002530-ao7kenbx	253	2	and	and	CC
cord-002530-ao7kenbx	253	3	IE2	ie2	JJ
cord-002530-ao7kenbx	253	4	probes	probe	NNS
cord-002530-ao7kenbx	253	5	were	be	VBD
cord-002530-ao7kenbx	253	6	generated	generate	VBN
cord-002530-ao7kenbx	253	7	by	by	IN
cord-002530-ao7kenbx	253	8	PCR	PCR	NNP
cord-002530-ao7kenbx	253	9	using	use	VBG
cord-002530-ao7kenbx	253	10	cDNA	cdna	NN
cord-002530-ao7kenbx	253	11	from	from	IN
cord-002530-ao7kenbx	253	12	TB40E	tb40e	NN
cord-002530-ao7kenbx	253	13	infected	infect	VBN
cord-002530-ao7kenbx	253	14	NHDFs	NHDFs	NNPS
cord-002530-ao7kenbx	253	15	(	(	-LRB-
cord-002530-ao7kenbx	253	16	as	as	IN
cord-002530-ao7kenbx	253	17	template	template	NN
cord-002530-ao7kenbx	253	18	)	)	-RRB-
cord-002530-ao7kenbx	253	19	and	and	CC
cord-002530-ao7kenbx	253	20	labelled	label	VBN
cord-002530-ao7kenbx	253	21	with	with	IN
cord-002530-ao7kenbx	253	22	Amersham	Amersham	NNP
cord-002530-ao7kenbx	253	23	Rediprime	Rediprime	NNP
cord-002530-ao7kenbx	253	24	II	II	NNP
cord-002530-ao7kenbx	253	25	DNA	dna	NN
cord-002530-ao7kenbx	253	26	labelling	labelling	NN
cord-002530-ao7kenbx	253	27	system	system	NN
cord-002530-ao7kenbx	253	28	(	(	-LRB-
cord-002530-ao7kenbx	253	29	GE	GE	NNP
cord-002530-ao7kenbx	253	30	Healthcare	Healthcare	NNP
cord-002530-ao7kenbx	253	31	)	)	-RRB-
cord-002530-ao7kenbx	253	32	with	with	IN
cord-002530-ao7kenbx	253	33	the	the	DT
cord-002530-ao7kenbx	253	34	following	follow	VBG
cord-002530-ao7kenbx	253	35	primers	primer	NNS
cord-002530-ao7kenbx	253	36	(	(	-LRB-
cord-002530-ao7kenbx	253	37	IE1	ie1	NN
cord-002530-ao7kenbx	253	38	:	:	:
cord-002530-ao7kenbx	253	39	TCAAACAGATTAAGGT	TCAAACAGATTAAGGT	NNP
cord-002530-ao7kenbx	253	40	TCGAGTGG	TCGAGTGG	NNP
cord-002530-ao7kenbx	253	41	,	,	,
cord-002530-ao7kenbx	253	42	and	and	CC
cord-002530-ao7kenbx	253	43	ATCCACATCTCCCGCTTATCCTCG	ATCCACATCTCCCGCTTATCCTCG	NNP
cord-002530-ao7kenbx	253	44	;	;	:
cord-002530-ao7kenbx	253	45	IE2	ie2	NN
cord-002530-ao7kenbx	253	46	:	:	:
cord-002530-ao7kenbx	253	47	TCATGGTGCGCATCTTC	TCATGGTGCGCATCTTC	NNP
cord-002530-ao7kenbx	253	48	TCCACC	TCCACC	NNP
cord-002530-ao7kenbx	253	49	,	,	,
cord-002530-ao7kenbx	253	50	and	and	CC
cord-002530-ao7kenbx	253	51	TTACTGAGACTTGTTCCTCAGGTCC	TTACTGAGACTTGTTCCTCAGGTCC	NNP
cord-002530-ao7kenbx	253	52	)	)	-RRB-
cord-002530-ao7kenbx	253	53	.	.	.
cord-002530-ao7kenbx	254	1	After	after	IN
cord-002530-ao7kenbx	254	2	hybridization	hybridization	NN
cord-002530-ao7kenbx	254	3	and	and	CC
cord-002530-ao7kenbx	254	4	wash	wash	NN
cord-002530-ao7kenbx	254	5	,	,	,
cord-002530-ao7kenbx	254	6	the	the	DT
cord-002530-ao7kenbx	254	7	membranes	membrane	NNS
cord-002530-ao7kenbx	254	8	were	be	VBD
cord-002530-ao7kenbx	254	9	exposed	expose	VBN
cord-002530-ao7kenbx	254	10	to	to	IN
cord-002530-ao7kenbx	254	11	autoradiography	autoradiography	NNP
cord-002530-ao7kenbx	254	12	film	film	NN
cord-002530-ao7kenbx	254	13	with	with	IN
cord-002530-ao7kenbx	254	14	an	an	DT
cord-002530-ao7kenbx	254	15	intensifying	intensify	VBG
cord-002530-ao7kenbx	254	16	screen	screen	NN
cord-002530-ao7kenbx	254	17	(	(	-LRB-
cord-002530-ao7kenbx	254	18	Biomax	Biomax	NNP
cord-002530-ao7kenbx	254	19	Transcreen	Transcreen	NNP
cord-002530-ao7kenbx	254	20	HE	HE	NNP
cord-002530-ao7kenbx	254	21	,	,	,
cord-002530-ao7kenbx	254	22	Kodak	Kodak	NNP
cord-002530-ao7kenbx	254	23	)	)	-RRB-
cord-002530-ao7kenbx	254	24	for	for	IN
cord-002530-ao7kenbx	254	25	visualization	visualization	NN
cord-002530-ao7kenbx	254	26	of	of	IN
cord-002530-ao7kenbx	254	27	bands	band	NNS
cord-002530-ao7kenbx	254	28	.	.	.
cord-002530-ao7kenbx	255	1	Cells	cell	NNS
cord-002530-ao7kenbx	255	2	were	be	VBD
cord-002530-ao7kenbx	255	3	transfected	transfecte	VBN
cord-002530-ao7kenbx	255	4	and	and	CC
cord-002530-ao7kenbx	255	5	infected	infect	VBN
cord-002530-ao7kenbx	255	6	as	as	IN
cord-002530-ao7kenbx	255	7	described	describe	VBN
cord-002530-ao7kenbx	255	8	above	above	RB
cord-002530-ao7kenbx	255	9	.	.	.
cord-002530-ao7kenbx	256	1	Total	Total	NNP
cord-002530-ao7kenbx	256	2	RNA	RNA	NNP
cord-002530-ao7kenbx	256	3	was	be	VBD
cord-002530-ao7kenbx	256	4	harvested	harvest	VBN
cord-002530-ao7kenbx	256	5	using	use	VBG
cord-002530-ao7kenbx	256	6	Trizol	Trizol	NNP
cord-002530-ao7kenbx	256	7	according	accord	VBG
cord-002530-ao7kenbx	256	8	to	to	IN
cord-002530-ao7kenbx	256	9	manufacturers	manufacturer	NNS
cord-002530-ao7kenbx	256	10	guidelines	guideline	NNS
cord-002530-ao7kenbx	256	11	.	.	.
cord-002530-ao7kenbx	257	1	Total	Total	NNP
cord-002530-ao7kenbx	257	2	RNA	RNA	NNP
cord-002530-ao7kenbx	257	3	was	be	VBD
cord-002530-ao7kenbx	257	4	submitted	submit	VBN
cord-002530-ao7kenbx	257	5	to	to	IN
cord-002530-ao7kenbx	257	6	Edinburgh	Edinburgh	NNP
cord-002530-ao7kenbx	257	7	Genomics	Genomics	NNP
cord-002530-ao7kenbx	257	8	for	for	IN
cord-002530-ao7kenbx	257	9	generation	generation	NN
cord-002530-ao7kenbx	257	10	of	of	IN
cord-002530-ao7kenbx	257	11	TruSeq	TruSeq	NNP
cord-002530-ao7kenbx	257	12	stranded	strand	VBN
cord-002530-ao7kenbx	257	13	libraries	library	NNS
cord-002530-ao7kenbx	257	14	and	and	CC
cord-002530-ao7kenbx	257	15	subjected	subject	VBN
cord-002530-ao7kenbx	257	16	to	to	IN
cord-002530-ao7kenbx	257	17	HiSeq	HiSeq	NNP
cord-002530-ao7kenbx	257	18	high	high	JJ
cord-002530-ao7kenbx	257	19	output	output	NN
cord-002530-ao7kenbx	257	20	v4	v4	NNP
cord-002530-ao7kenbx	257	21	125PE	125PE	NNP
cord-002530-ao7kenbx	257	22	sequencing	sequencing	NN
cord-002530-ao7kenbx	257	23	.	.	.
cord-002530-ao7kenbx	258	1	The	the	DT
cord-002530-ao7kenbx	258	2	strand	strand	NN
cord-002530-ao7kenbx	258	3	-	-	HYPH
cord-002530-ao7kenbx	258	4	specific	specific	JJ
cord-002530-ao7kenbx	258	5	RNA	RNA	NNP
cord-002530-ao7kenbx	258	6	-	-	HYPH
cord-002530-ao7kenbx	258	7	seq	seq	NN
cord-002530-ao7kenbx	258	8	reads	read	NNS
cord-002530-ao7kenbx	258	9	were	be	VBD
cord-002530-ao7kenbx	258	10	mapped	map	VBN
cord-002530-ao7kenbx	258	11	to	to	IN
cord-002530-ao7kenbx	258	12	a	a	DT
cord-002530-ao7kenbx	258	13	combined	combine	VBN
cord-002530-ao7kenbx	258	14	version	version	NN
cord-002530-ao7kenbx	258	15	of	of	IN
cord-002530-ao7kenbx	258	16	the	the	DT
cord-002530-ao7kenbx	258	17	human	human	NN
cord-002530-ao7kenbx	258	18	(	(	-LRB-
cord-002530-ao7kenbx	258	19	hg38	hg38	NNP
cord-002530-ao7kenbx	258	20	)	)	-RRB-
cord-002530-ao7kenbx	258	21	and	and	CC
cord-002530-ao7kenbx	258	22	human	human	JJ
cord-002530-ao7kenbx	258	23	herpesvirus	herpesvirus	NNP
cord-002530-ao7kenbx	258	24	5	5	CD
cord-002530-ao7kenbx	258	25	(	(	-LRB-
cord-002530-ao7kenbx	258	26	KF297339	kf297339	NN
cord-002530-ao7kenbx	258	27	)	)	-RRB-
cord-002530-ao7kenbx	258	28	genomes	genome	NNS
cord-002530-ao7kenbx	258	29	using	use	VBG
cord-002530-ao7kenbx	258	30	the	the	DT
cord-002530-ao7kenbx	258	31	HISAT	HISAT	NNP
cord-002530-ao7kenbx	258	32	spliced	splice	VBN
cord-002530-ao7kenbx	258	33	read	read	NN
cord-002530-ao7kenbx	258	34	mapper	mapper	NN
cord-002530-ao7kenbx	258	35	(	(	-LRB-
cord-002530-ao7kenbx	258	36	PMID:25751142	PMID:25751142	NNP
cord-002530-ao7kenbx	258	37	)	)	-RRB-
cord-002530-ao7kenbx	258	38	.	.	.
cord-002530-ao7kenbx	259	1	Only	only	RB
cord-002530-ao7kenbx	259	2	valid	valid	JJ
cord-002530-ao7kenbx	259	3	read	read	NN
cord-002530-ao7kenbx	259	4	pairs	pair	NNS
cord-002530-ao7kenbx	259	5	mapped	map	VBN
cord-002530-ao7kenbx	259	6	together	together	RB
cord-002530-ao7kenbx	259	7	in	in	IN
cord-002530-ao7kenbx	259	8	the	the	DT
cord-002530-ao7kenbx	259	9	correct	correct	JJ
cord-002530-ao7kenbx	259	10	orientation	orientation	NN
cord-002530-ao7kenbx	259	11	were	be	VBD
cord-002530-ao7kenbx	259	12	retained	retain	VBN
cord-002530-ao7kenbx	259	13	(	(	-LRB-
cord-002530-ao7kenbx	259	14	i.e.	i.e.	FW
cord-002530-ao7kenbx	259	15	carrying	carry	VBG
cord-002530-ao7kenbx	259	16	a	a	DT
cord-002530-ao7kenbx	259	17	SAM	SAM	NNP
cord-002530-ao7kenbx	259	18	flag	flag	NN
cord-002530-ao7kenbx	259	19	of	of	IN
cord-002530-ao7kenbx	259	20	one	one	CD
cord-002530-ao7kenbx	259	21	of	of	IN
cord-002530-ao7kenbx	259	22	83	83	CD
cord-002530-ao7kenbx	259	23	,	,	,
cord-002530-ao7kenbx	259	24	99	99	CD
cord-002530-ao7kenbx	259	25	,	,	,
cord-002530-ao7kenbx	259	26	147	147	CD
cord-002530-ao7kenbx	259	27	or	or	CC
cord-002530-ao7kenbx	259	28	163	163	CD
cord-002530-ao7kenbx	259	29	)	)	-RRB-
cord-002530-ao7kenbx	259	30	and	and	CC
cord-002530-ao7kenbx	259	31	a	a	DT
cord-002530-ao7kenbx	259	32	custom	custom	NN
cord-002530-ao7kenbx	259	33	Perl	Perl	NNP
cord-002530-ao7kenbx	259	34	script	script	NN
cord-002530-ao7kenbx	259	35	was	be	VBD
cord-002530-ao7kenbx	259	36	used	use	VBN
cord-002530-ao7kenbx	259	37	to	to	TO
cord-002530-ao7kenbx	259	38	count	count	VB
cord-002530-ao7kenbx	259	39	the	the	DT
cord-002530-ao7kenbx	259	40	number	number	NN
cord-002530-ao7kenbx	259	41	of	of	IN
cord-002530-ao7kenbx	259	42	these	these	DT
cord-002530-ao7kenbx	259	43	reads	read	VBZ
cord-002530-ao7kenbx	259	44	mapping	mapping	NN
cord-002530-ao7kenbx	259	45	to	to	IN
cord-002530-ao7kenbx	259	46	each	each	DT
cord-002530-ao7kenbx	259	47	exon	exon	NN
cord-002530-ao7kenbx	259	48	as	as	RB
cord-002530-ao7kenbx	259	49	well	well	RB
cord-002530-ao7kenbx	259	50	as	as	IN
cord-002530-ao7kenbx	259	51	the	the	DT
cord-002530-ao7kenbx	259	52	number	number	NN
cord-002530-ao7kenbx	259	53	of	of	IN
cord-002530-ao7kenbx	259	54	read	read	NN
cord-002530-ao7kenbx	259	55	pairs	pair	NNS
cord-002530-ao7kenbx	259	56	spanning	span	VBG
cord-002530-ao7kenbx	259	57	different	different	JJ
cord-002530-ao7kenbx	259	58	combinations	combination	NNS
cord-002530-ao7kenbx	259	59	of	of	IN
cord-002530-ao7kenbx	259	60	exons	exon	NNS
cord-002530-ao7kenbx	259	61	.	.	.
cord-002530-ao7kenbx	260	1	Drug	drug	NN
cord-002530-ao7kenbx	260	2	inhibitor	inhibitor	NN
cord-002530-ao7kenbx	260	3	studies	study	NNS
cord-002530-ao7kenbx	260	4	and	and	CC
cord-002530-ao7kenbx	260	5	cytotoxicity	cytotoxicity	NN
cord-002530-ao7kenbx	260	6	assay	assay	NN
cord-002530-ao7kenbx	261	1	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	262	1	(	(	-LRB-
cord-002530-ao7kenbx	262	2	Xcess	Xcess	NNP
cord-002530-ao7kenbx	262	3	Biosciences	Biosciences	NNPS
cord-002530-ao7kenbx	262	4	)	)	-RRB-
cord-002530-ao7kenbx	262	5	and	and	CC
cord-002530-ao7kenbx	262	6	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	262	7	(	(	-LRB-
cord-002530-ao7kenbx	262	8	Cambridge	Cambridge	NNP
cord-002530-ao7kenbx	262	9	Bioscience	Bioscience	NNP
cord-002530-ao7kenbx	262	10	)	)	-RRB-
cord-002530-ao7kenbx	262	11	were	be	VBD
cord-002530-ao7kenbx	262	12	dissolved	dissolve	VBN
cord-002530-ao7kenbx	262	13	in	in	IN
cord-002530-ao7kenbx	262	14	DMSO	DMSO	NNP
cord-002530-ao7kenbx	262	15	and	and	CC
cord-002530-ao7kenbx	262	16	added	add	VBD
cord-002530-ao7kenbx	262	17	to	to	IN
cord-002530-ao7kenbx	262	18	the	the	DT
cord-002530-ao7kenbx	262	19	cell	cell	NN
cord-002530-ao7kenbx	262	20	culture	culture	NN
cord-002530-ao7kenbx	262	21	at	at	IN
cord-002530-ao7kenbx	262	22	a	a	DT
cord-002530-ao7kenbx	262	23	working	work	VBG
cord-002530-ao7kenbx	262	24	concentration	concentration	NN
cord-002530-ao7kenbx	262	25	24	24	CD
cord-002530-ao7kenbx	262	26	hours	hour	NNS
cord-002530-ao7kenbx	262	27	before	before	IN
cord-002530-ao7kenbx	262	28	HCMV	HCMV	NNP
cord-002530-ao7kenbx	262	29	infection	infection	NN
cord-002530-ao7kenbx	262	30	.	.	.
cord-002530-ao7kenbx	263	1	Viability	viability	NN
cord-002530-ao7kenbx	263	2	for	for	IN
cord-002530-ao7kenbx	263	3	NMS-873	nms-873	RB
cord-002530-ao7kenbx	263	4	treated	treat	VBN
cord-002530-ao7kenbx	263	5	cells	cell	NNS
cord-002530-ao7kenbx	263	6	was	be	VBD
cord-002530-ao7kenbx	263	7	assessed	assess	VBN
cord-002530-ao7kenbx	263	8	using	use	VBG
cord-002530-ao7kenbx	263	9	the	the	DT
cord-002530-ao7kenbx	263	10	CellTiter	CellTiter	NNP
cord-002530-ao7kenbx	263	11	-	-	HYPH
cord-002530-ao7kenbx	263	12	Glo	Glo	NNP
cord-002530-ao7kenbx	263	13	luminescent	luminescent	JJ
cord-002530-ao7kenbx	263	14	cell	cell	NN
cord-002530-ao7kenbx	263	15	viability	viability	NN
cord-002530-ao7kenbx	263	16	assay	assay	NN
cord-002530-ao7kenbx	263	17	kit	kit	NN
cord-002530-ao7kenbx	263	18	(	(	-LRB-
cord-002530-ao7kenbx	263	19	Promega	Promega	NNP
cord-002530-ao7kenbx	263	20	)	)	-RRB-
cord-002530-ao7kenbx	263	21	and	and	CC
cord-002530-ao7kenbx	263	22	CellTiter	CellTiter	NNP
cord-002530-ao7kenbx	263	23	-	-	HYPH
cord-002530-ao7kenbx	263	24	Blue	Blue	NNP
cord-002530-ao7kenbx	263	25	(	(	-LRB-
cord-002530-ao7kenbx	263	26	Promega	Promega	NNP
cord-002530-ao7kenbx	263	27	)	)	-RRB-
cord-002530-ao7kenbx	263	28	120	120	CD
cord-002530-ao7kenbx	263	29	hours	hour	NNS
cord-002530-ao7kenbx	263	30	after	after	IN
cord-002530-ao7kenbx	263	31	NMS-873	NMS-873	NNP
cord-002530-ao7kenbx	263	32	addition	addition	NN
cord-002530-ao7kenbx	263	33	.	.	.
cord-002530-ao7kenbx	264	1	MG132	MG132	NNP
cord-002530-ao7kenbx	265	1	(	(	-LRB-
cord-002530-ao7kenbx	265	2	Cambridge	Cambridge	NNP
cord-002530-ao7kenbx	265	3	Bioscience	Bioscience	NNP
cord-002530-ao7kenbx	265	4	)	)	-RRB-
cord-002530-ao7kenbx	265	5	,	,	.
cord-002530-ao7kenbx	266	1	Pepstatin	Pepstatin	NNP
cord-002530-ao7kenbx	266	2	A	A	NNP
cord-002530-ao7kenbx	266	3	(	(	-LRB-
cord-002530-ao7kenbx	266	4	Sigma	Sigma	NNP
cord-002530-ao7kenbx	266	5	)	)	-RRB-
cord-002530-ao7kenbx	266	6	,	,	,
cord-002530-ao7kenbx	266	7	and	and	CC
cord-002530-ao7kenbx	266	8	E64	E64	NNP
cord-002530-ao7kenbx	266	9	(	(	-LRB-
cord-002530-ao7kenbx	266	10	Sigma	Sigma	NNP
cord-002530-ao7kenbx	266	11	)	)	-RRB-
cord-002530-ao7kenbx	266	12	were	be	VBD
cord-002530-ao7kenbx	266	13	dissolved	dissolve	VBN
cord-002530-ao7kenbx	266	14	in	in	IN
cord-002530-ao7kenbx	266	15	DMSO	DMSO	NNP
cord-002530-ao7kenbx	266	16	and	and	CC
cord-002530-ao7kenbx	266	17	added	add	VBD
cord-002530-ao7kenbx	266	18	to	to	IN
cord-002530-ao7kenbx	266	19	the	the	DT
cord-002530-ao7kenbx	266	20	cell	cell	NN
cord-002530-ao7kenbx	266	21	culture	culture	NN
cord-002530-ao7kenbx	266	22	24	24	CD
cord-002530-ao7kenbx	266	23	hours	hour	NNS
cord-002530-ao7kenbx	266	24	after	after	IN
cord-002530-ao7kenbx	266	25	HCMV	HCMV	NNP
cord-002530-ao7kenbx	266	26	infection	infection	NN
cord-002530-ao7kenbx	266	27	.	.	.
cord-002530-ao7kenbx	267	1	100	100	CD
cord-002530-ao7kenbx	267	2	μg	μg	NNP
cord-002530-ao7kenbx	267	3	/	/	SYM
cord-002530-ao7kenbx	267	4	ml	ml	NN
cord-002530-ao7kenbx	267	5	cycloheximide	cycloheximide	NN
cord-002530-ao7kenbx	267	6	(	(	-LRB-
cord-002530-ao7kenbx	267	7	in	in	IN
cord-002530-ao7kenbx	267	8	DMSO	DMSO	NNP
cord-002530-ao7kenbx	267	9	,	,	,
cord-002530-ao7kenbx	267	10	Sigma	Sigma	NNP
cord-002530-ao7kenbx	267	11	)	)	-RRB-
cord-002530-ao7kenbx	267	12	was	be	VBD
cord-002530-ao7kenbx	267	13	added	add	VBN
cord-002530-ao7kenbx	267	14	to	to	IN
cord-002530-ao7kenbx	267	15	the	the	DT
cord-002530-ao7kenbx	267	16	cell	cell	NN
cord-002530-ao7kenbx	267	17	culture	culture	NN
cord-002530-ao7kenbx	267	18	30	30	CD
cord-002530-ao7kenbx	267	19	minutes	minute	NNS
cord-002530-ao7kenbx	267	20	before	before	IN
cord-002530-ao7kenbx	267	21	HCMV	HCMV	NNP
cord-002530-ao7kenbx	267	22	infection	infection	NN
cord-002530-ao7kenbx	267	23	to	to	TO
cord-002530-ao7kenbx	267	24	block	block	VB
cord-002530-ao7kenbx	267	25	protein	protein	NN
cord-002530-ao7kenbx	267	26	biosynthesis	biosynthesis	NN
cord-002530-ao7kenbx	267	27	.	.	.
cord-002530-ao7kenbx	268	1	Laboratory	laboratory	NN
cord-002530-ao7kenbx	268	2	adapted	adapt	VBD
cord-002530-ao7kenbx	268	3	HCMV	HCMV	NNP
cord-002530-ao7kenbx	268	4	strain	strain	NN
cord-002530-ao7kenbx	268	5	AD169	ad169	NN
cord-002530-ao7kenbx	268	6	infected	infected	JJ
cord-002530-ao7kenbx	268	7	cells	cell	NNS
cord-002530-ao7kenbx	268	8	were	be	VBD
cord-002530-ao7kenbx	268	9	fixed	fix	VBN
cord-002530-ao7kenbx	268	10	and	and	CC
cord-002530-ao7kenbx	268	11	permeabilized	permeabilize	VBN
cord-002530-ao7kenbx	268	12	in	in	IN
cord-002530-ao7kenbx	268	13	Methanol	methanol	NN
cord-002530-ao7kenbx	268	14	:	:	:
cord-002530-ao7kenbx	268	15	Acetone	acetone	NN
cord-002530-ao7kenbx	268	16	solution	solution	NN
cord-002530-ao7kenbx	268	17	(	(	-LRB-
cord-002530-ao7kenbx	268	18	1:1	1:1	CD
cord-002530-ao7kenbx	268	19	)	)	-RRB-
cord-002530-ao7kenbx	268	20	for	for	IN
cord-002530-ao7kenbx	268	21	7	7	CD
cord-002530-ao7kenbx	268	22	minutes	minute	NNS
cord-002530-ao7kenbx	268	23	,	,	,
cord-002530-ao7kenbx	268	24	and	and	CC
cord-002530-ao7kenbx	268	25	then	then	RB
cord-002530-ao7kenbx	268	26	blocked	block	VBD
cord-002530-ao7kenbx	268	27	with	with	IN
cord-002530-ao7kenbx	268	28	5	5	CD
cord-002530-ao7kenbx	268	29	%	%	NN
cord-002530-ao7kenbx	268	30	human	human	JJ
cord-002530-ao7kenbx	268	31	serum	serum	NN
cord-002530-ao7kenbx	268	32	in	in	IN
cord-002530-ao7kenbx	268	33	PBS	PBS	NNP
cord-002530-ao7kenbx	268	34	for	for	IN
cord-002530-ao7kenbx	268	35	30	30	CD
cord-002530-ao7kenbx	268	36	minutes	minute	NNS
cord-002530-ao7kenbx	268	37	.	.	.
cord-002530-ao7kenbx	269	1	Primary	primary	JJ
cord-002530-ao7kenbx	269	2	and	and	CC
cord-002530-ao7kenbx	269	3	secondary	secondary	JJ
cord-002530-ao7kenbx	269	4	antibodies	antibody	NNS
cord-002530-ao7kenbx	269	5	were	be	VBD
cord-002530-ao7kenbx	269	6	diluted	dilute	VBN
cord-002530-ao7kenbx	269	7	with	with	IN
cord-002530-ao7kenbx	269	8	5	5	CD
cord-002530-ao7kenbx	269	9	%	%	NN
cord-002530-ao7kenbx	269	10	human	human	JJ
cord-002530-ao7kenbx	269	11	serum	serum	NN
cord-002530-ao7kenbx	269	12	in	in	IN
cord-002530-ao7kenbx	269	13	PBS	PBS	NNP
cord-002530-ao7kenbx	269	14	.	.	.
cord-002530-ao7kenbx	270	1	Cells	cell	NNS
cord-002530-ao7kenbx	270	2	were	be	VBD
cord-002530-ao7kenbx	270	3	washed	wash	VBN
cord-002530-ao7kenbx	270	4	with	with	IN
cord-002530-ao7kenbx	270	5	PBS	PBS	NNP
cord-002530-ao7kenbx	270	6	after	after	IN
cord-002530-ao7kenbx	270	7	primary	primary	JJ
cord-002530-ao7kenbx	270	8	and	and	CC
cord-002530-ao7kenbx	270	9	after	after	IN
cord-002530-ao7kenbx	270	10	secondary	secondary	JJ
cord-002530-ao7kenbx	270	11	antibody	antibody	NN
cord-002530-ao7kenbx	270	12	incubations	incubation	NNS
cord-002530-ao7kenbx	270	13	.	.	.
cord-002530-ao7kenbx	271	1	Primary	primary	JJ
cord-002530-ao7kenbx	271	2	antibodies	antibody	NNS
cord-002530-ao7kenbx	271	3	used	use	VBN
cord-002530-ao7kenbx	271	4	in	in	IN
cord-002530-ao7kenbx	271	5	this	this	DT
cord-002530-ao7kenbx	271	6	paper	paper	NN
cord-002530-ao7kenbx	271	7	are	be	VBP
cord-002530-ao7kenbx	271	8	mouse	mouse	NN
cord-002530-ao7kenbx	271	9	anti	anti	JJ
cord-002530-ao7kenbx	271	10	-	-	JJ
cord-002530-ao7kenbx	271	11	CMV	cmv	JJ
cord-002530-ao7kenbx	271	12	IE2	ie2	JJ
cord-002530-ao7kenbx	271	13	monoclonal	monoclonal	JJ
cord-002530-ao7kenbx	271	14	antibody	antibody	NN
cord-002530-ao7kenbx	271	15	(	(	-LRB-
cord-002530-ao7kenbx	271	16	12E2	12e2	CD
cord-002530-ao7kenbx	271	17	,	,	,
cord-002530-ao7kenbx	271	18	Santa	Santa	NNP
cord-002530-ao7kenbx	271	19	Cruz	Cruz	NNP
cord-002530-ao7kenbx	271	20	Biotechnology	Biotechnology	NNP
cord-002530-ao7kenbx	271	21	)	)	-RRB-
cord-002530-ao7kenbx	271	22	,	,	,
cord-002530-ao7kenbx	271	23	rabbit	rabbit	NN
cord-002530-ao7kenbx	271	24	anti	anti	JJ
cord-002530-ao7kenbx	271	25	-	-	JJ
cord-002530-ao7kenbx	271	26	VCP	vcp	JJ
cord-002530-ao7kenbx	271	27	polyclonal	polyclonal	JJ
cord-002530-ao7kenbx	271	28	antibody	antibody	NN
cord-002530-ao7kenbx	271	29	(	(	-LRB-
cord-002530-ao7kenbx	271	30	H-120	h-120	RB
cord-002530-ao7kenbx	271	31	,	,	,
cord-002530-ao7kenbx	271	32	Santa	Santa	NNP
cord-002530-ao7kenbx	271	33	Cruz	Cruz	NNP
cord-002530-ao7kenbx	271	34	Biotechnology	Biotechnology	NNP
cord-002530-ao7kenbx	271	35	)	)	-RRB-
cord-002530-ao7kenbx	271	36	at	at	IN
cord-002530-ao7kenbx	271	37	1:500	1:500	CD
cord-002530-ao7kenbx	271	38	.	.	.
cord-002530-ao7kenbx	272	1	Alexa	Alexa	NNP
cord-002530-ao7kenbx	272	2	-	-	HYPH
cord-002530-ao7kenbx	272	3	fluor-647	fluor-647	JJ
cord-002530-ao7kenbx	272	4	conjugated	conjugate	VBN
cord-002530-ao7kenbx	272	5	goat	goat	NN
cord-002530-ao7kenbx	272	6	anti	anti	JJ
cord-002530-ao7kenbx	272	7	-	-	JJ
cord-002530-ao7kenbx	272	8	mouse	mouse	NN
cord-002530-ao7kenbx	272	9	or	or	CC
cord-002530-ao7kenbx	272	10	Alexa	Alexa	NNP
cord-002530-ao7kenbx	272	11	-	-	HYPH
cord-002530-ao7kenbx	272	12	fluor-488	fluor-488	NNP
cord-002530-ao7kenbx	272	13	conjugated	conjugated	JJ
cord-002530-ao7kenbx	272	14	goatanti	goatanti	NN
cord-002530-ao7kenbx	272	15	-	-	HYPH
cord-002530-ao7kenbx	272	16	rabbit	rabbit	NN
cord-002530-ao7kenbx	272	17	IgG	IgG	NNP
cord-002530-ao7kenbx	272	18	secondary	secondary	JJ
cord-002530-ao7kenbx	272	19	antibodies	antibody	NNS
cord-002530-ao7kenbx	272	20	were	be	VBD
cord-002530-ao7kenbx	272	21	diluted	dilute	VBN
cord-002530-ao7kenbx	272	22	1:1000	1:1000	CD
cord-002530-ao7kenbx	272	23	.	.	.
cord-002530-ao7kenbx	273	1	All	all	DT
cord-002530-ao7kenbx	273	2	images	image	NNS
cord-002530-ao7kenbx	273	3	were	be	VBD
cord-002530-ao7kenbx	273	4	acquired	acquire	VBN
cord-002530-ao7kenbx	273	5	with	with	IN
cord-002530-ao7kenbx	273	6	Zeiss	Zeiss	NNP
cord-002530-ao7kenbx	273	7	LSM	LSM	NNP
cord-002530-ao7kenbx	273	8	710	710	CD
cord-002530-ao7kenbx	273	9	confocal	confocal	JJ
cord-002530-ao7kenbx	273	10	microscope	microscope	NN
cord-002530-ao7kenbx	273	11	fitted	fit	VBN
cord-002530-ao7kenbx	273	12	with	with	IN
cord-002530-ao7kenbx	273	13	63X/1.4	63x/1.4	CD
cord-002530-ao7kenbx	273	14	oil	oil	NN
cord-002530-ao7kenbx	273	15	-	-	HYPH
cord-002530-ao7kenbx	273	16	immersion	immersion	NN
cord-002530-ao7kenbx	273	17	objective	objective	JJ
cord-002530-ao7kenbx	273	18	lens	lens	NN
cord-002530-ao7kenbx	273	19	.	.	.
cord-002530-ao7kenbx	274	1	Total	Total	NNP
cord-002530-ao7kenbx	274	2	RNA	RNA	NNP
cord-002530-ao7kenbx	274	3	was	be	VBD
cord-002530-ao7kenbx	274	4	isolated	isolate	VBN
cord-002530-ao7kenbx	274	5	by	by	IN
cord-002530-ao7kenbx	274	6	using	use	VBG
cord-002530-ao7kenbx	274	7	Trizol	Trizol	NNP
cord-002530-ao7kenbx	274	8	solution	solution	NN
cord-002530-ao7kenbx	274	9	according	accord	VBG
cord-002530-ao7kenbx	274	10	to	to	IN
cord-002530-ao7kenbx	274	11	the	the	DT
cord-002530-ao7kenbx	274	12	manufacturer	manufacturer	NN
cord-002530-ao7kenbx	274	13	's	's	POS
cord-002530-ao7kenbx	274	14	protocol	protocol	NN
cord-002530-ao7kenbx	274	15	followed	follow	VBN
cord-002530-ao7kenbx	274	16	by	by	IN
cord-002530-ao7kenbx	274	17	DNase	DNase	NNP
cord-002530-ao7kenbx	274	18	(	(	-LRB-
cord-002530-ao7kenbx	274	19	Turbo	turbo	JJ
cord-002530-ao7kenbx	274	20	DNA	dna	NN
cord-002530-ao7kenbx	274	21	-	-	HYPH
cord-002530-ao7kenbx	274	22	free	free	JJ
cord-002530-ao7kenbx	274	23	kit	kit	NN
cord-002530-ao7kenbx	274	24	,	,	,
cord-002530-ao7kenbx	274	25	Ambion	Ambion	NNP
cord-002530-ao7kenbx	274	26	)	)	-RRB-
cord-002530-ao7kenbx	274	27	treatment	treatment	NN
cord-002530-ao7kenbx	274	28	,	,	,
cord-002530-ao7kenbx	274	29	and	and	CC
cord-002530-ao7kenbx	274	30	then	then	RB
cord-002530-ao7kenbx	274	31	reverse	reverse	VB
cord-002530-ao7kenbx	274	32	transcribed	transcribe	VBN
cord-002530-ao7kenbx	274	33	with	with	IN
cord-002530-ao7kenbx	274	34	poly	poly	NNP
cord-002530-ao7kenbx	274	35	T	T	NNP
cord-002530-ao7kenbx	274	36	primers	primer	NNS
cord-002530-ao7kenbx	274	37	using	use	VBG
cord-002530-ao7kenbx	274	38	High	High	NNP
cord-002530-ao7kenbx	274	39	Capacity	Capacity	NNP
cord-002530-ao7kenbx	274	40	cDNA	cdna	NN
cord-002530-ao7kenbx	274	41	Reverse	Reverse	NNP
cord-002530-ao7kenbx	274	42	Transcription	Transcription	NNP
cord-002530-ao7kenbx	274	43	Kit	kit	NN
cord-002530-ao7kenbx	274	44	(	(	-LRB-
cord-002530-ao7kenbx	274	45	Invitrogen	Invitrogen	NNP
cord-002530-ao7kenbx	274	46	)	)	-RRB-
cord-002530-ao7kenbx	274	47	.	.	.
cord-002530-ao7kenbx	275	1	Real	real	JJ
cord-002530-ao7kenbx	275	2	-	-	HYPH
cord-002530-ao7kenbx	275	3	Time	time	NN
cord-002530-ao7kenbx	275	4	PCR	PCR	NNP
cord-002530-ao7kenbx	275	5	was	be	VBD
cord-002530-ao7kenbx	275	6	carried	carry	VBN
cord-002530-ao7kenbx	275	7	out	out	RP
cord-002530-ao7kenbx	275	8	using	use	VBG
cord-002530-ao7kenbx	275	9	by	by	IN
cord-002530-ao7kenbx	275	10	Taqman	Taqman	NNP
cord-002530-ao7kenbx	275	11	assays	assay	NNS
cord-002530-ao7kenbx	275	12	with	with	IN
cord-002530-ao7kenbx	275	13	pre	pre	JJ
cord-002530-ao7kenbx	275	14	-	-	JJ
cord-002530-ao7kenbx	275	15	designed	design	VBN
cord-002530-ao7kenbx	275	16	gene	gene	NN
cord-002530-ao7kenbx	275	17	-	-	HYPH
cord-002530-ao7kenbx	275	18	specific	specific	JJ
cord-002530-ao7kenbx	275	19	primer	primer	NN
cord-002530-ao7kenbx	275	20	/	/	SYM
cord-002530-ao7kenbx	275	21	probe	probe	NN
cord-002530-ao7kenbx	275	22	set	set	NN
cord-002530-ao7kenbx	275	23	(	(	-LRB-
cord-002530-ao7kenbx	275	24	Applied	Applied	NNP
cord-002530-ao7kenbx	275	25	Biosystems	Biosystems	NNP
cord-002530-ao7kenbx	275	26	)	)	-RRB-
cord-002530-ao7kenbx	275	27	on	on	IN
cord-002530-ao7kenbx	275	28	Rotor	rotor	NN
cord-002530-ao7kenbx	275	29	gene	gene	NN
cord-002530-ao7kenbx	275	30	3000	3000	CD
cord-002530-ao7kenbx	275	31	(	(	-LRB-
cord-002530-ao7kenbx	275	32	Corbet	Corbet	NNP
cord-002530-ao7kenbx	275	33	Research	Research	NNP
cord-002530-ao7kenbx	275	34	)	)	-RRB-
cord-002530-ao7kenbx	275	35	.	.	.
cord-002530-ao7kenbx	276	1	Custom	custom	NN
cord-002530-ao7kenbx	276	2	primer	primer	NN
cord-002530-ao7kenbx	276	3	/	/	SYM
cord-002530-ao7kenbx	276	4	probe	probe	NN
cord-002530-ao7kenbx	276	5	set	set	VBN
cord-002530-ao7kenbx	276	6	are	be	VBP
cord-002530-ao7kenbx	276	7	CGTCAAACAGATTAAGGTTCGAGTGG	CGTCAAACAGATTAAGGTTCGAGTGG	NNP
cord-002530-ao7kenbx	276	8	,	,	,
cord-002530-ao7kenbx	276	9	CCACATCTCCCGCTTATCCTCG	CCACATCTCCCGCTTATCCTCG	NNP
cord-002530-ao7kenbx	276	10	,	,	,
cord-002530-ao7kenbx	276	11	and	and	CC
cord-002530-ao7kenbx	276	12	56-FAM	56-fam	CD
cord-002530-ao7kenbx	276	13	/	/	SYM
cord-002530-ao7kenbx	276	14	CATGCTCTG	CATGCTCTG	NNP
cord-002530-ao7kenbx	276	15	/	/	SYM
cord-002530-ao7kenbx	276	16	ZEN	ZEN	NNP
cord-002530-ao7kenbx	276	17	/	/	SYM
cord-002530-ao7kenbx	276	18	CATAGTTAGCCCAATACACTTCATCTC	CATAGTTAGCCCAATACACTTCATCTC	NNP
cord-002530-ao7kenbx	276	19	-	-	HYPH
cord-002530-ao7kenbx	276	20	CTCG/3IABkFQ	CTCG/3IABkFQ	NNP
cord-002530-ao7kenbx	276	21	for	for	IN
cord-002530-ao7kenbx	276	22	IE1	ie1	NN
cord-002530-ao7kenbx	276	23	,	,	,
cord-002530-ao7kenbx	276	24	and	and	CC
cord-002530-ao7kenbx	276	25	ATGGTGCGCATCTTCTCCACC	ATGGTGCGCATCTTCTCCACC	NNP
cord-002530-ao7kenbx	276	26	,	,	,
cord-002530-ao7kenbx	276	27	TTACTGAGACTTGTTCCTCAGGTCCTG	TTACTGAGACTTGTTCCTCAGGTCCTG	NNP
cord-002530-ao7kenbx	276	28	,	,	,
cord-002530-ao7kenbx	276	29	and	and	CC
cord-002530-ao7kenbx	276	30	56-FAM	56-fam	CD
cord-002530-ao7kenbx	276	31	/	/	SYM
cord-002530-ao7kenbx	276	32	CAGGCTCAG	CAGGCTCAG	NNP
cord-002530-ao7kenbx	276	33	/	/	SYM
cord-002530-ao7kenbx	276	34	ZEN	ZEN	NNP
cord-002530-ao7kenbx	276	35	/	/	SYM
cord-002530-ao7kenbx	276	36	GGTGTCCAGGTCTTCGGGAGG/3IABkFQ	GGTGTCCAGGTCTTCGGGAGG/3IABkFQ	NNP
cord-002530-ao7kenbx	276	37	for	for	IN
cord-002530-ao7kenbx	276	38	IE2	ie2	NN
cord-002530-ao7kenbx	276	39	.	.	.
cord-002530-ao7kenbx	277	1	Cells	cell	NNS
cord-002530-ao7kenbx	277	2	were	be	VBD
cord-002530-ao7kenbx	277	3	harvested	harvest	VBN
cord-002530-ao7kenbx	277	4	with	with	IN
cord-002530-ao7kenbx	277	5	trypsin	trypsin	NN
cord-002530-ao7kenbx	277	6	,	,	,
cord-002530-ao7kenbx	277	7	washed	wash	VBN
cord-002530-ao7kenbx	277	8	with	with	IN
cord-002530-ao7kenbx	277	9	PBS	PBS	NNP
cord-002530-ao7kenbx	277	10	,	,	,
cord-002530-ao7kenbx	277	11	and	and	CC
cord-002530-ao7kenbx	277	12	followed	follow	VBN
cord-002530-ao7kenbx	277	13	by	by	IN
cord-002530-ao7kenbx	277	14	fix	fix	NN
cord-002530-ao7kenbx	277	15	with	with	IN
cord-002530-ao7kenbx	277	16	70	70	CD
cord-002530-ao7kenbx	277	17	%	%	NN
cord-002530-ao7kenbx	277	18	cold	cold	JJ
cord-002530-ao7kenbx	277	19	ethanol	ethanol	NN
cord-002530-ao7kenbx	277	20	for	for	IN
cord-002530-ao7kenbx	277	21	30	30	CD
cord-002530-ao7kenbx	277	22	minutes	minute	NNS
cord-002530-ao7kenbx	277	23	at	at	IN
cord-002530-ao7kenbx	277	24	4˚C.	4˚c.	CD
cord-002530-ao7kenbx	278	1	Then	then	RB
cord-002530-ao7kenbx	278	2	the	the	DT
cord-002530-ao7kenbx	278	3	fixed	fix	VBN
cord-002530-ao7kenbx	278	4	cells	cell	NNS
cord-002530-ao7kenbx	278	5	were	be	VBD
cord-002530-ao7kenbx	278	6	washed	wash	VBN
cord-002530-ao7kenbx	278	7	twice	twice	RB
cord-002530-ao7kenbx	278	8	with	with	IN
cord-002530-ao7kenbx	278	9	PBS	PBS	NNP
cord-002530-ao7kenbx	278	10	,	,	,
cord-002530-ao7kenbx	278	11	treated	treat	VBN
cord-002530-ao7kenbx	278	12	with	with	IN
cord-002530-ao7kenbx	278	13	RNaseA	RNaseA	NNP
cord-002530-ao7kenbx	278	14	,	,	,
cord-002530-ao7kenbx	278	15	and	and	CC
cord-002530-ao7kenbx	278	16	labelled	label	VBN
cord-002530-ao7kenbx	278	17	with	with	IN
cord-002530-ao7kenbx	278	18	10	10	CD
cord-002530-ao7kenbx	278	19	μl	μl	NN
cord-002530-ao7kenbx	278	20	of	of	IN
cord-002530-ao7kenbx	278	21	propidium	propidium	NN
cord-002530-ao7kenbx	278	22	iodide	iodide	NN
cord-002530-ao7kenbx	278	23	(	(	-LRB-
cord-002530-ao7kenbx	278	24	1	1	CD
cord-002530-ao7kenbx	278	25	mg	mg	NNP
cord-002530-ao7kenbx	278	26	/	/	SYM
cord-002530-ao7kenbx	278	27	ml	ml	NN
cord-002530-ao7kenbx	278	28	stock	stock	NN
cord-002530-ao7kenbx	278	29	solution	solution	NN
cord-002530-ao7kenbx	278	30	,	,	,
cord-002530-ao7kenbx	278	31	Sigma	Sigma	NNP
cord-002530-ao7kenbx	278	32	)	)	-RRB-
cord-002530-ao7kenbx	278	33	.	.	.
cord-002530-ao7kenbx	279	1	Cell	cell	NN
cord-002530-ao7kenbx	279	2	cycle	cycle	NN
cord-002530-ao7kenbx	279	3	analysis	analysis	NN
cord-002530-ao7kenbx	279	4	was	be	VBD
cord-002530-ao7kenbx	279	5	first	first	RB
cord-002530-ao7kenbx	279	6	carried	carry	VBN
cord-002530-ao7kenbx	279	7	out	out	RP
cord-002530-ao7kenbx	279	8	using	use	VBG
cord-002530-ao7kenbx	279	9	BD	BD	NNP
cord-002530-ao7kenbx	279	10	LSRFortessa	LSRFortessa	NNP
cord-002530-ao7kenbx	279	11	X20	X20	NNP
cord-002530-ao7kenbx	279	12	,	,	,
cord-002530-ao7kenbx	279	13	and	and	CC
cord-002530-ao7kenbx	279	14	then	then	RB
cord-002530-ao7kenbx	279	15	further	further	RB
cord-002530-ao7kenbx	279	16	analyzed	analyze	VBD
cord-002530-ao7kenbx	279	17	using	use	VBG
cord-002530-ao7kenbx	279	18	FlowJo	FlowJo	NNP
cord-002530-ao7kenbx	279	19	software	software	NN
cord-002530-ao7kenbx	279	20	.	.	.
cord-002530-ao7kenbx	280	1	Quantification	quantification	NN
cord-002530-ao7kenbx	280	2	of	of	IN
cord-002530-ao7kenbx	280	3	difference	difference	NN
cord-002530-ao7kenbx	280	4	in	in	IN
cord-002530-ao7kenbx	280	5	IE1	ie1	NN
cord-002530-ao7kenbx	280	6	protein	protein	NN
cord-002530-ao7kenbx	280	7	levels	level	NNS
cord-002530-ao7kenbx	280	8	between	between	IN
cord-002530-ao7kenbx	280	9	knockdown	knockdown	NN
cord-002530-ao7kenbx	280	10	of	of	IN
cord-002530-ao7kenbx	280	11	VCP	VCP	NNP
cord-002530-ao7kenbx	280	12	versus	versus	IN
cord-002530-ao7kenbx	280	13	ganciclovir	ganciclovir	NNP
cord-002530-ao7kenbx	280	14	treatment	treatment	NN
cord-002530-ao7kenbx	280	15	.	.	.
cord-002530-ao7kenbx	281	1	Quantification	quantification	NN
cord-002530-ao7kenbx	281	2	is	be	VBZ
cord-002530-ao7kenbx	281	3	compared	compare	VBN
cord-002530-ao7kenbx	281	4	to	to	IN
cord-002530-ao7kenbx	281	5	negative	negative	JJ
cord-002530-ao7kenbx	281	6	control	control	NN
cord-002530-ao7kenbx	281	7	for	for	IN
cord-002530-ao7kenbx	281	8	each	each	DT
cord-002530-ao7kenbx	281	9	time	time	NN
cord-002530-ao7kenbx	281	10	point	point	NN
cord-002530-ao7kenbx	281	11	.	.	.
cord-002530-ao7kenbx	282	1	(	(	-LRB-
cord-002530-ao7kenbx	282	2	D	D	NNP
cord-002530-ao7kenbx	282	3	)	)	-RRB-
cord-002530-ao7kenbx	282	4	Relative	Relative	NNP
cord-002530-ao7kenbx	282	5	IE1	ie1	NN
cord-002530-ao7kenbx	282	6	and	and	CC
cord-002530-ao7kenbx	282	7	IE2	ie2	NN
cord-002530-ao7kenbx	282	8	transcript	transcript	NN
cord-002530-ao7kenbx	282	9	levels	level	NNS
cord-002530-ao7kenbx	282	10	normalised	normalise	VBN
cord-002530-ao7kenbx	282	11	to	to	IN
cord-002530-ao7kenbx	282	12	MIE	MIE	NNP
cord-002530-ao7kenbx	282	13	shared	share	VBN
cord-002530-ao7kenbx	282	14	exons	exon	NNS
cord-002530-ao7kenbx	282	15	.	.	.
cord-002530-ao7kenbx	283	1	Levels	level	NNS
cord-002530-ao7kenbx	283	2	were	be	VBD
cord-002530-ao7kenbx	283	3	determined	determine	VBN
cord-002530-ao7kenbx	283	4	by	by	IN
cord-002530-ao7kenbx	283	5	qRT	qRT	NNP
cord-002530-ao7kenbx	283	6	-	-	HYPH
cord-002530-ao7kenbx	283	7	PCR	PCR	NNP
cord-002530-ao7kenbx	283	8	using	use	VBG
cord-002530-ao7kenbx	283	9	primer	primer	NN
cord-002530-ao7kenbx	283	10	probes	probe	NNS
cord-002530-ao7kenbx	283	11	specific	specific	JJ
cord-002530-ao7kenbx	283	12	to	to	IN
cord-002530-ao7kenbx	283	13	exon	exon	NN
cord-002530-ao7kenbx	283	14	1	1	CD
cord-002530-ao7kenbx	283	15	to	to	IN
cord-002530-ao7kenbx	283	16	3	3	CD
cord-002530-ao7kenbx	283	17	,	,	,
cord-002530-ao7kenbx	283	18	exon	exon	NN
cord-002530-ao7kenbx	283	19	4	4	CD
cord-002530-ao7kenbx	283	20	or	or	CC
cord-002530-ao7kenbx	283	21	exon	exon	NN
cord-002530-ao7kenbx	283	22	5	5	CD
cord-002530-ao7kenbx	283	23	.	.	.
cord-002530-ao7kenbx	284	1	Exon	Exon	NNP
cord-002530-ao7kenbx	284	2	4	4	CD
cord-002530-ao7kenbx	284	3	and	and	CC
cord-002530-ao7kenbx	284	4	5	5	CD
cord-002530-ao7kenbx	284	5	levels	level	NNS
cord-002530-ao7kenbx	284	6	were	be	VBD
cord-002530-ao7kenbx	284	7	then	then	RB
cord-002530-ao7kenbx	284	8	normalised	normalise	VBN
cord-002530-ao7kenbx	284	9	to	to	TO
cord-002530-ao7kenbx	284	10	exon	exon	NN
cord-002530-ao7kenbx	284	11	1	1	CD
cord-002530-ao7kenbx	284	12	-	-	SYM
cord-002530-ao7kenbx	284	13	3	3	CD
cord-002530-ao7kenbx	284	14	for	for	IN
cord-002530-ao7kenbx	284	15	VCP	VCP	NNP
cord-002530-ao7kenbx	284	16	knockdown	knockdown	NN
cord-002530-ao7kenbx	284	17	cells	cell	NNS
cord-002530-ao7kenbx	284	18	(	(	-LRB-
cord-002530-ao7kenbx	284	19	D	D	NNP
cord-002530-ao7kenbx	284	20	)	)	-RRB-
cord-002530-ao7kenbx	284	21	or	or	CC
cord-002530-ao7kenbx	284	22	cells	cell	NNS
cord-002530-ao7kenbx	284	23	treated	treat	VBN
cord-002530-ao7kenbx	284	24	with	with	IN
cord-002530-ao7kenbx	284	25	Ganciclovir	Ganciclovir	NNP
cord-002530-ao7kenbx	284	26	(	(	-LRB-
cord-002530-ao7kenbx	284	27	5	5	CD
cord-002530-ao7kenbx	284	28	μM	μM	NNP
cord-002530-ao7kenbx	284	29	)	)	-RRB-
cord-002530-ao7kenbx	284	30	.	.	.
cord-002530-ao7kenbx	285	1	Cells	cell	NNS
cord-002530-ao7kenbx	285	2	were	be	VBD
cord-002530-ao7kenbx	285	3	treated	treat	VBN
cord-002530-ao7kenbx	285	4	100	100	CD
cord-002530-ao7kenbx	285	5	μg	μg	NNS
cord-002530-ao7kenbx	285	6	/	/	SYM
cord-002530-ao7kenbx	285	7	ml	ml	NN
cord-002530-ao7kenbx	285	8	cycloheximide	cycloheximide	NN
cord-002530-ao7kenbx	285	9	,	,	,
cord-002530-ao7kenbx	285	10	30	30	CD
cord-002530-ao7kenbx	285	11	minutes	minute	NNS
cord-002530-ao7kenbx	285	12	prior	prior	RB
cord-002530-ao7kenbx	285	13	to	to	IN
cord-002530-ao7kenbx	285	14	infection	infection	NN
cord-002530-ao7kenbx	285	15	to	to	TO
cord-002530-ao7kenbx	285	16	block	block	VB
cord-002530-ao7kenbx	285	17	de	de	NNP
cord-002530-ao7kenbx	285	18	novo	novo	NNP
cord-002530-ao7kenbx	285	19	protein	protein	NNP
cord-002530-ao7kenbx	285	20	synthesis	synthesis	NNP
cord-002530-ao7kenbx	285	21	and	and	CC
cord-002530-ao7kenbx	285	22	total	total	JJ
cord-002530-ao7kenbx	285	23	RNA	RNA	NNP
cord-002530-ao7kenbx	285	24	harvested	harvest	VBN
cord-002530-ao7kenbx	285	25	at	at	IN
cord-002530-ao7kenbx	285	26	indicated	indicate	VBN
cord-002530-ao7kenbx	285	27	times	time	NNS
cord-002530-ao7kenbx	285	28	.	.	.
cord-002530-ao7kenbx	286	1	IE1	ie1	NN
cord-002530-ao7kenbx	286	2	and	and	CC
cord-002530-ao7kenbx	286	3	IE2	IE2	NNP
cord-002530-ao7kenbx	286	4	transcript	transcript	NN
cord-002530-ao7kenbx	286	5	levels	level	NNS
cord-002530-ao7kenbx	286	6	were	be	VBD
cord-002530-ao7kenbx	286	7	determined	determine	VBN
cord-002530-ao7kenbx	286	8	by	by	IN
cord-002530-ao7kenbx	286	9	Northern	northern	JJ
cord-002530-ao7kenbx	286	10	blot	blot	NN
cord-002530-ao7kenbx	286	11	analysis	analysis	NN
cord-002530-ao7kenbx	286	12	.	.	.
cord-002530-ao7kenbx	287	1	(	(	-LRB-
cord-002530-ao7kenbx	287	2	DOCX	DOCX	NNP
cord-002530-ao7kenbx	287	3	)	)	-RRB-
cord-002530-ao7kenbx	287	4	S1	S1	NNP
cord-002530-ao7kenbx	287	5	Table	Table	NNP
cord-002530-ao7kenbx	287	6	.	.	.
cord-002530-ao7kenbx	288	1	siRNA	siRNA	NNP
cord-002530-ao7kenbx	288	2	screen	screen	NNP
cord-002530-ao7kenbx	288	3	data	datum	NNS
cord-002530-ao7kenbx	288	4	.	.	.
cord-002530-ao7kenbx	289	1	Raw	raw	JJ
cord-002530-ao7kenbx	289	2	data	datum	NNS
cord-002530-ao7kenbx	289	3	from	from	IN
cord-002530-ao7kenbx	289	4	the	the	DT
cord-002530-ao7kenbx	289	5	three	three	CD
cord-002530-ao7kenbx	289	6	repeated	repeat	VBN
cord-002530-ao7kenbx	289	7	siRNA	siRNA	NNP
cord-002530-ao7kenbx	289	8	screens	screen	NNS
cord-002530-ao7kenbx	289	9	including	include	VBG
cord-002530-ao7kenbx	289	10	technical	technical	JJ
cord-002530-ao7kenbx	289	11	repeats	repeat	NNS
cord-002530-ao7kenbx	289	12	.	.	.
cord-002530-ao7kenbx	290	1	Average	average	JJ
cord-002530-ao7kenbx	290	2	over	over	IN
cord-002530-ao7kenbx	290	3	the	the	DT
cord-002530-ao7kenbx	290	4	three	three	CD
cord-002530-ao7kenbx	290	5	experiments	experiment	NNS
cord-002530-ao7kenbx	290	6	as	as	RB
cord-002530-ao7kenbx	290	7	well	well	RB
cord-002530-ao7kenbx	290	8	as	as	IN
cord-002530-ao7kenbx	290	9	Z	z	NN
cord-002530-ao7kenbx	290	10	scores	score	NNS
cord-002530-ao7kenbx	290	11	and	and	CC
cord-002530-ao7kenbx	290	12	standard	standard	JJ
cord-002530-ao7kenbx	290	13	deviations	deviation	NNS
cord-002530-ao7kenbx	290	14	are	be	VBP
cord-002530-ao7kenbx	290	15	shown	show	VBN
cord-002530-ao7kenbx	290	16	.	.	.
cord-002530-ao7kenbx	291	1	(	(	-LRB-
cord-002530-ao7kenbx	291	2	XLSX	XLSX	NNP
cord-002530-ao7kenbx	291	3	)	)	-RRB-
cord-002530-ao7kenbx	291	4	S2	S2	NNP
cord-002530-ao7kenbx	291	5	Table	Table	NNP
cord-002530-ao7kenbx	291	6	.	.	.
cord-002530-ao7kenbx	292	1	Exon	Exon	NNP
cord-002530-ao7kenbx	292	2	read	read	VBD
cord-002530-ao7kenbx	292	3	count	count	NN
cord-002530-ao7kenbx	292	4	ratios	ratio	NNS
cord-002530-ao7kenbx	292	5	.	.	.
cord-002530-ao7kenbx	293	1	Total	total	JJ
cord-002530-ao7kenbx	293	2	read	read	NN
cord-002530-ao7kenbx	293	3	counts	count	VBZ
cord-002530-ao7kenbx	293	4	for	for	IN
cord-002530-ao7kenbx	293	5	each	each	DT
cord-002530-ao7kenbx	293	6	of	of	IN
cord-002530-ao7kenbx	293	7	the	the	DT
cord-002530-ao7kenbx	293	8	five	five	CD
cord-002530-ao7kenbx	293	9	exons	exon	NNS
cord-002530-ao7kenbx	293	10	for	for	IN
cord-002530-ao7kenbx	293	11	each	each	DT
cord-002530-ao7kenbx	293	12	condition	condition	NN
cord-002530-ao7kenbx	293	13	are	be	VBP
cord-002530-ao7kenbx	293	14	shown	show	VBN
cord-002530-ao7kenbx	293	15	along	along	IN
cord-002530-ao7kenbx	293	16	with	with	IN
cord-002530-ao7kenbx	293	17	ratio	ratio	NN
cord-002530-ao7kenbx	293	18	to	to	IN
cord-002530-ao7kenbx	293	19	total	total	JJ
cord-002530-ao7kenbx	293	20	calculations	calculation	NNS
cord-002530-ao7kenbx	293	21	and	and	CC
cord-002530-ao7kenbx	293	22	differential	differential	NN
cord-002530-ao7kenbx	293	23	between	between	IN
cord-002530-ao7kenbx	293	24	negative	negative	JJ
cord-002530-ao7kenbx	293	25	control	control	NN
cord-002530-ao7kenbx	293	26	and	and	CC
cord-002530-ao7kenbx	293	27	VCP	VCP	NNP
cord-002530-ao7kenbx	293	28	knockdown	knockdown	NN
cord-002530-ao7kenbx	293	29	samples	sample	NNS
cord-002530-ao7kenbx	293	30	.	.	.
cord-002530-ao7kenbx	294	1	(	(	-LRB-
cord-002530-ao7kenbx	294	2	XLSX	XLSX	NNP
cord-002530-ao7kenbx	294	3	)	)	-RRB-
cord-002530-ao7kenbx	294	4	S3	S3	NNP
cord-002530-ao7kenbx	294	5	Table	Table	NNP
cord-002530-ao7kenbx	294	6	.	.	.
cord-002530-ao7kenbx	295	1	Splice	splice	NN
cord-002530-ao7kenbx	295	2	junction	junction	NN
cord-002530-ao7kenbx	295	3	counts	count	NNS
cord-002530-ao7kenbx	295	4	.	.	.
cord-002530-ao7kenbx	296	1	Total	total	JJ
cord-002530-ao7kenbx	296	2	read	read	NN
cord-002530-ao7kenbx	296	3	counts	count	VBZ
cord-002530-ao7kenbx	296	4	across	across	IN
cord-002530-ao7kenbx	296	5	each	each	DT
cord-002530-ao7kenbx	296	6	of	of	IN
cord-002530-ao7kenbx	296	7	the	the	DT
cord-002530-ao7kenbx	296	8	3	3	CD
cord-002530-ao7kenbx	296	9	MIE	MIE	NNP
cord-002530-ao7kenbx	296	10	junctions	junction	NNS
cord-002530-ao7kenbx	296	11	are	be	VBP
cord-002530-ao7kenbx	296	12	shown	show	VBN
cord-002530-ao7kenbx	296	13	along	along	IN
cord-002530-ao7kenbx	296	14	with	with	IN
cord-002530-ao7kenbx	296	15	ratio	ratio	NN
cord-002530-ao7kenbx	296	16	calculations	calculation	NNS
cord-002530-ao7kenbx	296	17	defining	define	VBG
cord-002530-ao7kenbx	296	18	the	the	DT
cord-002530-ao7kenbx	296	19	differential	differential	NN
cord-002530-ao7kenbx	296	20	between	between	IN
cord-002530-ao7kenbx	296	21	exon	exon	NN
cord-002530-ao7kenbx	296	22	2	2	CD
cord-002530-ao7kenbx	296	23	to	to	IN
cord-002530-ao7kenbx	296	24	3	3	CD
cord-002530-ao7kenbx	296	25	,	,	,
cord-002530-ao7kenbx	296	26	3	3	CD
cord-002530-ao7kenbx	296	27	to	to	IN
cord-002530-ao7kenbx	296	28	4	4	CD
cord-002530-ao7kenbx	296	29	and	and	CC
cord-002530-ao7kenbx	296	30	3	3	CD
cord-002530-ao7kenbx	296	31	to	to	TO
cord-002530-ao7kenbx	296	32	5	5	CD
cord-002530-ao7kenbx	296	33	in	in	IN
cord-002530-ao7kenbx	296	34	log	log	NN
cord-002530-ao7kenbx	296	35	2	2	CD
cord-002530-ao7kenbx	296	36	.	.	.
cord-002530-ao7kenbx	297	1	(	(	-LRB-
cord-002530-ao7kenbx	297	2	XLSX	XLSX	NNP
cord-002530-ao7kenbx	297	3	)	)	-RRB-
cord-002530-ao7kenbx	297	4	S4	S4	NNP
cord-002530-ao7kenbx	297	5	Table	Table	NNP
cord-002530-ao7kenbx	297	6	.	.	.
cord-002530-ao7kenbx	298	1	Relative	relative	JJ
cord-002530-ao7kenbx	298	2	expression	expression	NN
cord-002530-ao7kenbx	298	3	levels	level	NNS
cord-002530-ao7kenbx	298	4	of	of	IN
cord-002530-ao7kenbx	298	5	exons	exon	NNS
cord-002530-ao7kenbx	298	6	4	4	CD
cord-002530-ao7kenbx	298	7	and	and	CC
cord-002530-ao7kenbx	298	8	5	5	CD
cord-002530-ao7kenbx	298	9	are	be	VBP
cord-002530-ao7kenbx	298	10	significantly	significantly	RB
cord-002530-ao7kenbx	298	11	dependent	dependent	JJ
cord-002530-ao7kenbx	298	12	on	on	IN
cord-002530-ao7kenbx	298	13	the	the	DT
cord-002530-ao7kenbx	298	14	combination	combination	NN
cord-002530-ao7kenbx	298	15	of	of	IN
cord-002530-ao7kenbx	298	16	timepoint	timepoint	NN
cord-002530-ao7kenbx	298	17	and	and	CC
cord-002530-ao7kenbx	298	18	VCP	VCP	NNP
cord-002530-ao7kenbx	298	19	status	status	NN
cord-002530-ao7kenbx	298	20	.	.	.
cord-002530-ao7kenbx	299	1	Linear	linear	JJ
cord-002530-ao7kenbx	299	2	model	model	NN
cord-002530-ao7kenbx	299	3	results	result	NNS
cord-002530-ao7kenbx	299	4	of	of	IN
cord-002530-ao7kenbx	299	5	testing	test	VBG
cord-002530-ao7kenbx	299	6	associations	association	NNS
cord-002530-ao7kenbx	299	7	between	between	IN
cord-002530-ao7kenbx	299	8	the	the	DT
cord-002530-ao7kenbx	299	9	relative	relative	JJ
cord-002530-ao7kenbx	299	10	expression	expression	NN
cord-002530-ao7kenbx	299	11	levels	level	NNS
cord-002530-ao7kenbx	299	12	of	of	IN
cord-002530-ao7kenbx	299	13	each	each	DT
cord-002530-ao7kenbx	299	14	exon	exon	NN
cord-002530-ao7kenbx	299	15	and	and	CC
cord-002530-ao7kenbx	299	16	both	both	DT
cord-002530-ao7kenbx	299	17	time	time	NN
cord-002530-ao7kenbx	299	18	and	and	CC
cord-002530-ao7kenbx	299	19	siVCP	sivcp	DT
cord-002530-ao7kenbx	299	20	treatment	treatment	NN
cord-002530-ao7kenbx	299	21	.	.	.
cord-002530-ao7kenbx	300	1	Relative	relative	JJ
cord-002530-ao7kenbx	300	2	expression	expression	NN
cord-002530-ao7kenbx	300	3	levels	level	NNS
cord-002530-ao7kenbx	300	4	being	be	VBG
cord-002530-ao7kenbx	300	5	measured	measure	VBN
cord-002530-ao7kenbx	300	6	as	as	IN
cord-002530-ao7kenbx	300	7	the	the	DT
cord-002530-ao7kenbx	300	8	proportion	proportion	NN
cord-002530-ao7kenbx	300	9	of	of	IN
cord-002530-ao7kenbx	300	10	the	the	DT
cord-002530-ao7kenbx	300	11	transcript	transcript	NN
cord-002530-ao7kenbx	300	12	's	's	POS
cord-002530-ao7kenbx	300	13	reads	read	VBZ
cord-002530-ao7kenbx	300	14	that	that	WDT
cord-002530-ao7kenbx	300	15	mapped	map	VBD
cord-002530-ao7kenbx	300	16	to	to	IN
cord-002530-ao7kenbx	300	17	the	the	DT
cord-002530-ao7kenbx	300	18	corresponding	corresponding	JJ
cord-002530-ao7kenbx	300	19	exon	exon	NN
cord-002530-ao7kenbx	300	20	in	in	IN
cord-002530-ao7kenbx	300	21	that	that	DT
cord-002530-ao7kenbx	300	22	sample	sample	NN
cord-002530-ao7kenbx	300	23	.	.	.
cord-002530-ao7kenbx	301	1	Coefficients	coefficient	NNS
cord-002530-ao7kenbx	301	2	,	,	,
cord-002530-ao7kenbx	301	3	standard	standard	JJ
cord-002530-ao7kenbx	301	4	errors	error	NNS
cord-002530-ao7kenbx	301	5	(	(	-LRB-
cord-002530-ao7kenbx	301	6	in	in	IN
cord-002530-ao7kenbx	301	7	brackets	bracket	NNS
cord-002530-ao7kenbx	301	8	)	)	-RRB-
cord-002530-ao7kenbx	301	9	and	and	CC
cord-002530-ao7kenbx	301	10	p	p	NN
cord-002530-ao7kenbx	301	11	values	value	NNS
cord-002530-ao7kenbx	301	12	are	be	VBP
cord-002530-ao7kenbx	301	13	shown	show	VBN
cord-002530-ao7kenbx	301	14	.	.	.
cord-002530-ao7kenbx	302	1	Associations	association	NNS
cord-002530-ao7kenbx	302	2	between	between	IN
cord-002530-ao7kenbx	302	3	relative	relative	JJ
cord-002530-ao7kenbx	302	4	expression	expression	NN
cord-002530-ao7kenbx	302	5	levels	level	NNS
cord-002530-ao7kenbx	302	6	of	of	IN
cord-002530-ao7kenbx	302	7	exons	exon	NNS
cord-002530-ao7kenbx	302	8	4	4	CD
cord-002530-ao7kenbx	302	9	and	and	CC
cord-002530-ao7kenbx	302	10	5	5	CD
cord-002530-ao7kenbx	302	11	and	and	CC
cord-002530-ao7kenbx	302	12	timepoint	timepoint	NN
cord-002530-ao7kenbx	302	13	are	be	VBP
cord-002530-ao7kenbx	302	14	dependent	dependent	JJ
cord-002530-ao7kenbx	302	15	on	on	IN
cord-002530-ao7kenbx	302	16	VCP	vcp	NN
cord-002530-ao7kenbx	302	17	status	status	NN
cord-002530-ao7kenbx	302	18	as	as	IN
cord-002530-ao7kenbx	302	19	demonstrated	demonstrate	VBN
cord-002530-ao7kenbx	302	20	by	by	IN
cord-002530-ao7kenbx	302	21	the	the	DT
cord-002530-ao7kenbx	302	22	significant	significant	JJ
cord-002530-ao7kenbx	302	23	interaction	interaction	NN
cord-002530-ao7kenbx	302	24	term	term	NN
cord-002530-ao7kenbx	302	25	(	(	-LRB-
cord-002530-ao7kenbx	302	26	Time	time	NN
cord-002530-ao7kenbx	302	27	:	:	:
cord-002530-ao7kenbx	302	28	siVCP	sivcp	LS
cord-002530-ao7kenbx	302	29	)	)	-RRB-
cord-002530-ao7kenbx	302	30	.	.	.
cord-002530-ao7kenbx	302	31	 	 	_SP
cord-002530-ao7kenbx	303	1	Regulation	regulation	NN
cord-002530-ao7kenbx	303	2	and	and	CC
cord-002530-ao7kenbx	303	3	tissue	tissue	NN
cord-002530-ao7kenbx	303	4	-	-	HYPH
cord-002530-ao7kenbx	303	5	specific	specific	JJ
cord-002530-ao7kenbx	303	6	expression	expression	NN
cord-002530-ao7kenbx	303	7	of	of	IN
cord-002530-ao7kenbx	303	8	human	human	JJ
cord-002530-ao7kenbx	303	9	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	303	10	Cytomegalovirus	Cytomegalovirus	NNP
cord-002530-ao7kenbx	303	11	disease	disease	NN
cord-002530-ao7kenbx	303	12	of	of	IN
cord-002530-ao7kenbx	303	13	late	late	JJ
cord-002530-ao7kenbx	303	14	onset	onset	NN
cord-002530-ao7kenbx	303	15	following	follow	VBG
cord-002530-ao7kenbx	303	16	renal	renal	JJ
cord-002530-ao7kenbx	303	17	transplantation	transplantation	NN
cord-002530-ao7kenbx	303	18	:	:	:
cord-002530-ao7kenbx	304	1	a	a	DT
cord-002530-ao7kenbx	304	2	potentially	potentially	RB
cord-002530-ao7kenbx	304	3	fatal	fatal	JJ
cord-002530-ao7kenbx	304	4	entity	entity	NN
cord-002530-ao7kenbx	304	5	Acquired	acquire	VBD
cord-002530-ao7kenbx	304	6	cytomegalovirus	cytomegalovirus	JJ
cord-002530-ao7kenbx	304	7	infection	infection	NN
cord-002530-ao7kenbx	304	8	in	in	IN
cord-002530-ao7kenbx	304	9	preterm	preterm	JJR
cord-002530-ao7kenbx	304	10	infants	infant	NNS
cord-002530-ao7kenbx	304	11	Transfusion	transfusion	NN
cord-002530-ao7kenbx	304	12	-	-	HYPH
cord-002530-ao7kenbx	304	13	associated	associate	VBN
cord-002530-ao7kenbx	304	14	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	304	15	infections	infection	NNS
cord-002530-ao7kenbx	304	16	Cytomegalovirus	Cytomegalovirus	NNP
cord-002530-ao7kenbx	304	17	infection	infection	NN
cord-002530-ao7kenbx	304	18	of	of	IN
cord-002530-ao7kenbx	304	19	human	human	JJ
cord-002530-ao7kenbx	304	20	blood	blood	NN
cord-002530-ao7kenbx	304	21	cells	cell	NNS
cord-002530-ao7kenbx	304	22	Death	death	NN
cord-002530-ao7kenbx	304	23	in	in	IN
cord-002530-ao7kenbx	304	24	the	the	DT
cord-002530-ao7kenbx	304	25	AIDS	AIDS	NNP
cord-002530-ao7kenbx	304	26	patient	patient	NN
cord-002530-ao7kenbx	304	27	:	:	:
cord-002530-ao7kenbx	304	28	role	role	NN
cord-002530-ao7kenbx	304	29	of	of	IN
cord-002530-ao7kenbx	304	30	cytomegalovirus	cytomegalovirus	JJ
cord-002530-ao7kenbx	304	31	Interstitial	interstitial	JJ
cord-002530-ao7kenbx	304	32	pneumonia	pneumonia	NN
cord-002530-ao7kenbx	304	33	and	and	CC
cord-002530-ao7kenbx	304	34	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	304	35	infection	infection	NN
cord-002530-ao7kenbx	304	36	as	as	IN
cord-002530-ao7kenbx	304	37	complications	complication	NNS
cord-002530-ao7kenbx	304	38	of	of	IN
cord-002530-ao7kenbx	304	39	human	human	JJ
cord-002530-ao7kenbx	304	40	marrow	marrow	NN
cord-002530-ao7kenbx	304	41	transplantation	transplantation	NN
cord-002530-ao7kenbx	305	1	The	the	DT
cord-002530-ao7kenbx	305	2	use	use	NN
cord-002530-ao7kenbx	305	3	of	of	IN
cord-002530-ao7kenbx	305	4	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	305	5	-	-	HYPH
cord-002530-ao7kenbx	305	6	screened	screen	VBN
cord-002530-ao7kenbx	305	7	blood	blood	NN
cord-002530-ao7kenbx	305	8	in	in	IN
cord-002530-ao7kenbx	305	9	neonates	neonate	NNS
cord-002530-ao7kenbx	305	10	Progress	Progress	NNP
cord-002530-ao7kenbx	305	11	on	on	IN
cord-002530-ao7kenbx	305	12	human	human	JJ
cord-002530-ao7kenbx	305	13	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	305	14	vaccines	vaccine	NNS
cord-002530-ao7kenbx	305	15	for	for	IN
cord-002530-ao7kenbx	305	16	prevention	prevention	NN
cord-002530-ao7kenbx	305	17	of	of	IN
cord-002530-ao7kenbx	305	18	congenital	congenital	JJ
cord-002530-ao7kenbx	305	19	infection	infection	NN
cord-002530-ao7kenbx	305	20	and	and	CC
cord-002530-ao7kenbx	305	21	disease	disease	NN
cord-002530-ao7kenbx	305	22	Analysis	Analysis	NNP
cord-002530-ao7kenbx	305	23	of	of	IN
cord-002530-ao7kenbx	305	24	splice	splice	NN
cord-002530-ao7kenbx	305	25	variants	variant	NNS
cord-002530-ao7kenbx	305	26	of	of	IN
cord-002530-ao7kenbx	305	27	the	the	DT
cord-002530-ao7kenbx	305	28	immediate	immediate	JJ
cord-002530-ao7kenbx	305	29	-	-	HYPH
cord-002530-ao7kenbx	305	30	early	early	JJ
cord-002530-ao7kenbx	305	31	1	1	CD
cord-002530-ao7kenbx	305	32	region	region	NN
cord-002530-ao7kenbx	305	33	of	of	IN
cord-002530-ao7kenbx	305	34	human	human	JJ
cord-002530-ao7kenbx	305	35	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	306	1	The	the	DT
cord-002530-ao7kenbx	306	2	human	human	JJ
cord-002530-ao7kenbx	306	3	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	306	4	IE2	ie2	NN
cord-002530-ao7kenbx	306	5	86-kilodalton	86-kilodalton	CD
cord-002530-ao7kenbx	306	6	protein	protein	NN
cord-002530-ao7kenbx	306	7	interacts	interact	VBZ
cord-002530-ao7kenbx	306	8	with	with	IN
cord-002530-ao7kenbx	306	9	an	an	DT
cord-002530-ao7kenbx	306	10	early	early	JJ
cord-002530-ao7kenbx	306	11	gene	gene	NN
cord-002530-ao7kenbx	306	12	promoter	promoter	NN
cord-002530-ao7kenbx	306	13	via	via	IN
cord-002530-ao7kenbx	306	14	site	site	NN
cord-002530-ao7kenbx	306	15	-	-	HYPH
cord-002530-ao7kenbx	306	16	specific	specific	JJ
cord-002530-ao7kenbx	306	17	DNA	dna	NN
cord-002530-ao7kenbx	306	18	binding	binding	NN
cord-002530-ao7kenbx	306	19	and	and	CC
cord-002530-ao7kenbx	306	20	protein	protein	NN
cord-002530-ao7kenbx	306	21	-	-	HYPH
cord-002530-ao7kenbx	306	22	protein	protein	NN
cord-002530-ao7kenbx	306	23	associations	association	NNS
cord-002530-ao7kenbx	307	1	Structural	structural	JJ
cord-002530-ao7kenbx	307	2	analysis	analysis	NN
cord-002530-ao7kenbx	307	3	of	of	IN
cord-002530-ao7kenbx	307	4	the	the	DT
cord-002530-ao7kenbx	307	5	major	major	JJ
cord-002530-ao7kenbx	307	6	immediate	immediate	JJ
cord-002530-ao7kenbx	307	7	early	early	JJ
cord-002530-ao7kenbx	307	8	gene	gene	NN
cord-002530-ao7kenbx	307	9	of	of	IN
cord-002530-ao7kenbx	307	10	human	human	JJ
cord-002530-ao7kenbx	307	11	cytomegalovirus	cytomegalovirus	NNP
cord-002530-ao7kenbx	307	12	Human	Human	NNP
cord-002530-ao7kenbx	307	13	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	307	14	persistence	persistence	NN
cord-002530-ao7kenbx	307	15	Aspects	aspect	NNS
cord-002530-ao7kenbx	307	16	of	of	IN
cord-002530-ao7kenbx	307	17	human	human	JJ
cord-002530-ao7kenbx	307	18	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	307	19	latency	latency	NN
cord-002530-ao7kenbx	307	20	and	and	CC
cord-002530-ao7kenbx	307	21	reactivation	reactivation	NN
cord-002530-ao7kenbx	307	22	Human	human	JJ
cord-002530-ao7kenbx	307	23	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	307	24	with	with	IN
cord-002530-ao7kenbx	307	25	IE-2	IE-2	NNP
cord-002530-ao7kenbx	307	26	(	(	-LRB-
cord-002530-ao7kenbx	307	27	UL122	UL122	NNP
cord-002530-ao7kenbx	307	28	)	)	-RRB-
cord-002530-ao7kenbx	307	29	deleted	delete	VBN
cord-002530-ao7kenbx	307	30	fails	fail	VBZ
cord-002530-ao7kenbx	307	31	to	to	TO
cord-002530-ao7kenbx	307	32	express	express	VB
cord-002530-ao7kenbx	307	33	early	early	JJ
cord-002530-ao7kenbx	307	34	lytic	lytic	JJ
cord-002530-ao7kenbx	307	35	genes	gene	NNS
cord-002530-ao7kenbx	307	36	Multiple	multiple	JJ
cord-002530-ao7kenbx	307	37	spliced	splice	VBN
cord-002530-ao7kenbx	307	38	and	and	CC
cord-002530-ao7kenbx	307	39	unspliced	unsplice	VBN
cord-002530-ao7kenbx	307	40	transcripts	transcript	NNS
cord-002530-ao7kenbx	307	41	from	from	IN
cord-002530-ao7kenbx	307	42	human	human	JJ
cord-002530-ao7kenbx	307	43	cytomegalovirus	cytomegalovirus	JJ
cord-002530-ao7kenbx	307	44	immediate	immediate	JJ
cord-002530-ao7kenbx	307	45	-	-	HYPH
cord-002530-ao7kenbx	307	46	early	early	JJ
cord-002530-ao7kenbx	307	47	region	region	NN
cord-002530-ao7kenbx	307	48	2	2	CD
cord-002530-ao7kenbx	307	49	and	and	CC
cord-002530-ao7kenbx	307	50	evidence	evidence	NN
cord-002530-ao7kenbx	307	51	for	for	IN
cord-002530-ao7kenbx	307	52	a	a	DT
cord-002530-ao7kenbx	307	53	common	common	JJ
cord-002530-ao7kenbx	307	54	initiation	initiation	NN
cord-002530-ao7kenbx	307	55	site	site	NN
cord-002530-ao7kenbx	307	56	within	within	IN
cord-002530-ao7kenbx	307	57	immediate	immediate	JJ
cord-002530-ao7kenbx	307	58	-	-	HYPH
cord-002530-ao7kenbx	307	59	early	early	JJ
cord-002530-ao7kenbx	307	60	region	region	NN
cord-002530-ao7kenbx	307	61	1	1	CD
cord-002530-ao7kenbx	307	62	Widespread	Widespread	NNP
cord-002530-ao7kenbx	307	63	mRNA	mRNA	NNP
cord-002530-ao7kenbx	307	64	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	307	65	events	event	NNS
cord-002530-ao7kenbx	307	66	in	in	IN
cord-002530-ao7kenbx	307	67	introns	intron	NNS
cord-002530-ao7kenbx	308	1	indicate	indicate	VBP
cord-002530-ao7kenbx	308	2	dynamic	dynamic	JJ
cord-002530-ao7kenbx	308	3	interplay	interplay	NN
cord-002530-ao7kenbx	308	4	between	between	IN
cord-002530-ao7kenbx	308	5	polyadenylation	polyadenylation	NN
cord-002530-ao7kenbx	308	6	and	and	CC
cord-002530-ao7kenbx	308	7	splicing	splice	VBG
cord-002530-ao7kenbx	308	8	Emerging	Emerging	NNP
cord-002530-ao7kenbx	308	9	functions	function	NNS
cord-002530-ao7kenbx	308	10	of	of	IN
cord-002530-ao7kenbx	308	11	the	the	DT
cord-002530-ao7kenbx	308	12	VCP	VCP	NNP
cord-002530-ao7kenbx	308	13	/	/	SYM
cord-002530-ao7kenbx	308	14	p97	p97	CD
cord-002530-ao7kenbx	308	15	AAA	AAA	NNP
cord-002530-ao7kenbx	308	16	-	-	HYPH
cord-002530-ao7kenbx	308	17	ATPase	ATPase	NNP
cord-002530-ao7kenbx	308	18	in	in	IN
cord-002530-ao7kenbx	308	19	the	the	DT
cord-002530-ao7kenbx	308	20	ubiquitin	ubiquitin	NN
cord-002530-ao7kenbx	308	21	system	system	NN
cord-002530-ao7kenbx	308	22	Role	role	NN
cord-002530-ao7kenbx	308	23	of	of	IN
cord-002530-ao7kenbx	308	24	Cdc48	Cdc48	NNP
cord-002530-ao7kenbx	308	25	/	/	SYM
cord-002530-ao7kenbx	308	26	p97	p97	CD
cord-002530-ao7kenbx	308	27	as	as	IN
cord-002530-ao7kenbx	308	28	a	a	DT
cord-002530-ao7kenbx	308	29	SUMO	SUMO	NNP
cord-002530-ao7kenbx	308	30	-	-	HYPH
cord-002530-ao7kenbx	308	31	targeted	target	VBN
cord-002530-ao7kenbx	308	32	segregase	segregase	NN
cord-002530-ao7kenbx	308	33	curbing	curb	VBG
cord-002530-ao7kenbx	308	34	Rad51-Rad52	rad51-rad52	NN
cord-002530-ao7kenbx	308	35	interaction	interaction	NN
cord-002530-ao7kenbx	308	36	p97	p97	CD
cord-002530-ao7kenbx	308	37	complexes	complex	NNS
cord-002530-ao7kenbx	308	38	as	as	IN
cord-002530-ao7kenbx	308	39	signal	signal	NN
cord-002530-ao7kenbx	308	40	integration	integration	NN
cord-002530-ao7kenbx	308	41	hubs	hub	NNS
cord-002530-ao7kenbx	308	42	The	the	DT
cord-002530-ao7kenbx	308	43	VCP	VCP	NNP
cord-002530-ao7kenbx	308	44	/	/	SYM
cord-002530-ao7kenbx	308	45	p97	p97	CD
cord-002530-ao7kenbx	308	46	system	system	NN
cord-002530-ao7kenbx	308	47	at	at	IN
cord-002530-ao7kenbx	308	48	a	a	DT
cord-002530-ao7kenbx	308	49	glance	glance	NN
cord-002530-ao7kenbx	308	50	:	:	:
cord-002530-ao7kenbx	308	51	connecting	connect	VBG
cord-002530-ao7kenbx	308	52	cellular	cellular	JJ
cord-002530-ao7kenbx	308	53	function	function	NN
cord-002530-ao7kenbx	308	54	to	to	IN
cord-002530-ao7kenbx	308	55	disease	disease	NN
cord-002530-ao7kenbx	308	56	pathogenesis	pathogenesis	NN
cord-002530-ao7kenbx	309	1	Should	Should	MD
cord-002530-ao7kenbx	309	2	I	-PRON-	PRP
cord-002530-ao7kenbx	309	3	stay	stay	VB
cord-002530-ao7kenbx	309	4	or	or	CC
cord-002530-ao7kenbx	310	1	should	should	MD
cord-002530-ao7kenbx	310	2	I	-PRON-	PRP
cord-002530-ao7kenbx	310	3	go	go	VB
cord-002530-ao7kenbx	310	4	:	:	:
cord-002530-ao7kenbx	311	1	VCP	VCP	NNP
cord-002530-ao7kenbx	311	2	/	/	SYM
cord-002530-ao7kenbx	311	3	p97-mediated	p97-mediated	JJ
cord-002530-ao7kenbx	311	4	chromatin	chromatin	NN
cord-002530-ao7kenbx	311	5	extraction	extraction	NN
cord-002530-ao7kenbx	311	6	in	in	IN
cord-002530-ao7kenbx	311	7	the	the	DT
cord-002530-ao7kenbx	311	8	DNA	dna	NN
cord-002530-ao7kenbx	311	9	damage	damage	NN
cord-002530-ao7kenbx	311	10	response	response	NN
cord-002530-ao7kenbx	311	11	Cdc48	Cdc48	NNP
cord-002530-ao7kenbx	311	12	/	/	SYM
cord-002530-ao7kenbx	311	13	p97	p97	NN
cord-002530-ao7kenbx	311	14	promotes	promote	VBZ
cord-002530-ao7kenbx	311	15	reformation	reformation	NN
cord-002530-ao7kenbx	311	16	of	of	IN
cord-002530-ao7kenbx	311	17	the	the	DT
cord-002530-ao7kenbx	311	18	nucleus	nucleus	NN
cord-002530-ao7kenbx	311	19	by	by	IN
cord-002530-ao7kenbx	311	20	extracting	extract	VBG
cord-002530-ao7kenbx	311	21	the	the	DT
cord-002530-ao7kenbx	311	22	kinase	kinase	NN
cord-002530-ao7kenbx	311	23	Aurora	Aurora	NNP
cord-002530-ao7kenbx	311	24	B	B	NNP
cord-002530-ao7kenbx	311	25	from	from	IN
cord-002530-ao7kenbx	311	26	chromatin	chromatin	JJ
cord-002530-ao7kenbx	311	27	Valosin	Valosin	NNP
cord-002530-ao7kenbx	311	28	-	-	HYPH
cord-002530-ao7kenbx	311	29	containing	contain	VBG
cord-002530-ao7kenbx	311	30	protein	protein	NN
cord-002530-ao7kenbx	311	31	(	(	-LRB-
cord-002530-ao7kenbx	311	32	VCP	VCP	NNP
cord-002530-ao7kenbx	311	33	/	/	SYM
cord-002530-ao7kenbx	311	34	p97	p97	CD
cord-002530-ao7kenbx	311	35	)	)	-RRB-
cord-002530-ao7kenbx	311	36	is	be	VBZ
cord-002530-ao7kenbx	311	37	required	require	VBN
cord-002530-ao7kenbx	311	38	for	for	IN
cord-002530-ao7kenbx	311	39	poliovirus	poliovirus	NN
cord-002530-ao7kenbx	311	40	replication	replication	NN
cord-002530-ao7kenbx	311	41	and	and	CC
cord-002530-ao7kenbx	311	42	is	be	VBZ
cord-002530-ao7kenbx	311	43	involved	involve	VBN
cord-002530-ao7kenbx	311	44	in	in	IN
cord-002530-ao7kenbx	311	45	cellular	cellular	JJ
cord-002530-ao7kenbx	311	46	protein	protein	NN
cord-002530-ao7kenbx	311	47	secretion	secretion	NN
cord-002530-ao7kenbx	311	48	pathway	pathway	NN
cord-002530-ao7kenbx	311	49	in	in	IN
cord-002530-ao7kenbx	311	50	poliovirus	poliovirus	NN
cord-002530-ao7kenbx	311	51	infection	infection	NN
cord-002530-ao7kenbx	311	52	Genome	genome	NN
cord-002530-ao7kenbx	311	53	-	-	HYPH
cord-002530-ao7kenbx	311	54	wide	wide	JJ
cord-002530-ao7kenbx	311	55	RNAi	RNAi	NNS
cord-002530-ao7kenbx	311	56	screen	screen	NN
cord-002530-ao7kenbx	311	57	identifies	identify	VBZ
cord-002530-ao7kenbx	311	58	SEC61A	sec61a	NN
cord-002530-ao7kenbx	311	59	and	and	CC
cord-002530-ao7kenbx	311	60	VCP	VCP	NNP
cord-002530-ao7kenbx	311	61	as	as	IN
cord-002530-ao7kenbx	311	62	conserved	conserved	JJ
cord-002530-ao7kenbx	311	63	regulators	regulator	NNS
cord-002530-ao7kenbx	311	64	of	of	IN
cord-002530-ao7kenbx	311	65	Sindbis	Sindbis	NNP
cord-002530-ao7kenbx	311	66	virus	virus	NN
cord-002530-ao7kenbx	311	67	entry	entry	NN
cord-002530-ao7kenbx	311	68	Genome	Genome	NNP
cord-002530-ao7kenbx	311	69	-	-	HYPH
cord-002530-ao7kenbx	311	70	Wide	wide	JJ
cord-002530-ao7kenbx	311	71	Screen	screen	NN
cord-002530-ao7kenbx	312	1	Reveals	reveal	VBZ
cord-002530-ao7kenbx	312	2	Vcp	Vcp	NNP
cord-002530-ao7kenbx	312	3	Requirement	Requirement	NNP
cord-002530-ao7kenbx	312	4	for	for	IN
cord-002530-ao7kenbx	312	5	Coronavirus	Coronavirus	NNP
cord-002530-ao7kenbx	312	6	Exit	Exit	NNP
cord-002530-ao7kenbx	312	7	from	from	IN
cord-002530-ao7kenbx	312	8	Endosomes	Endosomes	NNP
cord-002530-ao7kenbx	313	1	The	the	DT
cord-002530-ao7kenbx	313	2	AAA	AAA	NNP
cord-002530-ao7kenbx	313	3	ATPase	ATPase	NNP
cord-002530-ao7kenbx	313	4	Cdc48	Cdc48	NNP
cord-002530-ao7kenbx	313	5	/	/	SYM
cord-002530-ao7kenbx	313	6	p97	p97	CD
cord-002530-ao7kenbx	313	7	and	and	CC
cord-002530-ao7kenbx	313	8	its	-PRON-	PRP$
cord-002530-ao7kenbx	313	9	partners	partner	NNS
cord-002530-ao7kenbx	313	10	transport	transport	VBP
cord-002530-ao7kenbx	313	11	proteins	protein	NNS
cord-002530-ao7kenbx	313	12	from	from	IN
cord-002530-ao7kenbx	313	13	the	the	DT
cord-002530-ao7kenbx	313	14	ER	ER	NNP
cord-002530-ao7kenbx	313	15	into	into	IN
cord-002530-ao7kenbx	313	16	the	the	DT
cord-002530-ao7kenbx	313	17	cytosol	cytosol	NN
cord-002530-ao7kenbx	314	1	Systematic	systematic	JJ
cord-002530-ao7kenbx	314	2	microRNA	microRNA	NNP
cord-002530-ao7kenbx	314	3	analysis	analysis	NN
cord-002530-ao7kenbx	314	4	identifies	identify	VBZ
cord-002530-ao7kenbx	314	5	ATP6V0C	ATP6V0C	VBN
cord-002530-ao7kenbx	314	6	as	as	IN
cord-002530-ao7kenbx	314	7	an	an	DT
cord-002530-ao7kenbx	314	8	essential	essential	JJ
cord-002530-ao7kenbx	314	9	host	host	NN
cord-002530-ao7kenbx	314	10	factor	factor	NN
cord-002530-ao7kenbx	314	11	for	for	IN
cord-002530-ao7kenbx	314	12	human	human	JJ
cord-002530-ao7kenbx	314	13	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	314	14	replication	replication	NN
cord-002530-ao7kenbx	314	15	V	v	NN
cord-002530-ao7kenbx	314	16	for	for	IN
cord-002530-ao7kenbx	314	17	victory	victory	NN
cord-002530-ao7kenbx	314	18	-	-	:
cord-002530-ao7kenbx	314	19	a	a	DT
cord-002530-ao7kenbx	314	20	V1-ATPase	v1-atpase	NN
cord-002530-ao7kenbx	314	21	structure	structure	NN
cord-002530-ao7kenbx	314	22	revealed	reveal	VBD
cord-002530-ao7kenbx	314	23	Proteasome	Proteasome	NNP
cord-002530-ao7kenbx	314	24	subunits	subunit	VBZ
cord-002530-ao7kenbx	314	25	relocalize	relocalize	NNS
cord-002530-ao7kenbx	314	26	during	during	IN
cord-002530-ao7kenbx	314	27	human	human	JJ
cord-002530-ao7kenbx	314	28	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	314	29	infection	infection	NN
cord-002530-ao7kenbx	314	30	,	,	,
cord-002530-ao7kenbx	314	31	and	and	CC
cord-002530-ao7kenbx	314	32	proteasome	proteasome	NN
cord-002530-ao7kenbx	314	33	activity	activity	NN
cord-002530-ao7kenbx	314	34	is	be	VBZ
cord-002530-ao7kenbx	314	35	necessary	necessary	JJ
cord-002530-ao7kenbx	314	36	for	for	IN
cord-002530-ao7kenbx	314	37	efficient	efficient	JJ
cord-002530-ao7kenbx	314	38	viral	viral	JJ
cord-002530-ao7kenbx	314	39	gene	gene	NN
cord-002530-ao7kenbx	314	40	transcription	transcription	NN
cord-002530-ao7kenbx	314	41	Identification	identification	NN
cord-002530-ao7kenbx	314	42	of	of	IN
cord-002530-ao7kenbx	314	43	binding	bind	VBG
cord-002530-ao7kenbx	314	44	sites	site	NNS
cord-002530-ao7kenbx	314	45	for	for	IN
cord-002530-ao7kenbx	314	46	the	the	DT
cord-002530-ao7kenbx	314	47	86-kilodalton	86-kilodalton	CD
cord-002530-ao7kenbx	314	48	IE2	ie2	NN
cord-002530-ao7kenbx	314	49	protein	protein	NN
cord-002530-ao7kenbx	314	50	of	of	IN
cord-002530-ao7kenbx	314	51	human	human	JJ
cord-002530-ao7kenbx	314	52	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	314	53	within	within	IN
cord-002530-ao7kenbx	314	54	an	an	DT
cord-002530-ao7kenbx	314	55	IE2-responsive	ie2-responsive	JJ
cord-002530-ao7kenbx	314	56	viral	viral	JJ
cord-002530-ao7kenbx	314	57	early	early	JJ
cord-002530-ao7kenbx	314	58	promoter	promoter	NN
cord-002530-ao7kenbx	314	59	Separate	separate	JJ
cord-002530-ao7kenbx	314	60	DNA	dna	NN
cord-002530-ao7kenbx	314	61	elements	element	NNS
cord-002530-ao7kenbx	314	62	containing	contain	VBG
cord-002530-ao7kenbx	314	63	ATF	ATF	NNP
cord-002530-ao7kenbx	314	64	/	/	SYM
cord-002530-ao7kenbx	314	65	CREB	CREB	NNP
cord-002530-ao7kenbx	314	66	and	and	CC
cord-002530-ao7kenbx	314	67	IE86	IE86	NNP
cord-002530-ao7kenbx	314	68	binding	bind	VBG
cord-002530-ao7kenbx	314	69	sites	site	NNS
cord-002530-ao7kenbx	314	70	differentially	differentially	RB
cord-002530-ao7kenbx	314	71	regulate	regulate	VBP
cord-002530-ao7kenbx	314	72	the	the	DT
cord-002530-ao7kenbx	314	73	human	human	JJ
cord-002530-ao7kenbx	314	74	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	314	75	UL112	UL112	NNP
cord-002530-ao7kenbx	314	76	-	-	HYPH
cord-002530-ao7kenbx	314	77	113	113	CD
cord-002530-ao7kenbx	314	78	promoter	promoter	NN
cord-002530-ao7kenbx	314	79	at	at	IN
cord-002530-ao7kenbx	314	80	early	early	JJ
cord-002530-ao7kenbx	314	81	and	and	CC
cord-002530-ao7kenbx	314	82	late	late	JJ
cord-002530-ao7kenbx	314	83	times	time	NNS
cord-002530-ao7kenbx	314	84	in	in	IN
cord-002530-ao7kenbx	314	85	the	the	DT
cord-002530-ao7kenbx	314	86	infection	infection	NN
cord-002530-ao7kenbx	314	87	Inhibition	Inhibition	NNP
cord-002530-ao7kenbx	314	88	of	of	IN
cord-002530-ao7kenbx	314	89	human	human	JJ
cord-002530-ao7kenbx	314	90	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	314	91	immediate	immediate	JJ
cord-002530-ao7kenbx	314	92	-	-	HYPH
cord-002530-ao7kenbx	314	93	early	early	JJ
cord-002530-ao7kenbx	314	94	gene	gene	NN
cord-002530-ao7kenbx	314	95	expression	expression	NN
cord-002530-ao7kenbx	314	96	by	by	IN
cord-002530-ao7kenbx	314	97	cyclin	cyclin	NN
cord-002530-ao7kenbx	314	98	A2-dependent	a2-dependent	NN
cord-002530-ao7kenbx	314	99	kinase	kinase	NN
cord-002530-ao7kenbx	314	100	activity	activity	NN
cord-002530-ao7kenbx	315	1	Cyclin	Cyclin	NNP
cord-002530-ao7kenbx	315	2	-	-	HYPH
cord-002530-ao7kenbx	315	3	dependent	dependent	JJ
cord-002530-ao7kenbx	315	4	kinase	kinase	NN
cord-002530-ao7kenbx	315	5	activity	activity	NN
cord-002530-ao7kenbx	315	6	is	be	VBZ
cord-002530-ao7kenbx	315	7	required	require	VBN
cord-002530-ao7kenbx	315	8	at	at	IN
cord-002530-ao7kenbx	315	9	early	early	JJ
cord-002530-ao7kenbx	315	10	times	time	NNS
cord-002530-ao7kenbx	315	11	for	for	IN
cord-002530-ao7kenbx	315	12	accurate	accurate	JJ
cord-002530-ao7kenbx	315	13	processing	processing	NN
cord-002530-ao7kenbx	315	14	and	and	CC
cord-002530-ao7kenbx	315	15	accumulation	accumulation	NN
cord-002530-ao7kenbx	315	16	of	of	IN
cord-002530-ao7kenbx	315	17	the	the	DT
cord-002530-ao7kenbx	315	18	human	human	JJ
cord-002530-ao7kenbx	315	19	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	315	20	UL122	UL122	NNP
cord-002530-ao7kenbx	315	21	-	-	HYPH
cord-002530-ao7kenbx	315	22	123	123	CD
cord-002530-ao7kenbx	315	23	and	and	CC
cord-002530-ao7kenbx	315	24	UL37	UL37	NNP
cord-002530-ao7kenbx	315	25	immediate	immediate	JJ
cord-002530-ao7kenbx	315	26	-	-	HYPH
cord-002530-ao7kenbx	315	27	early	early	JJ
cord-002530-ao7kenbx	315	28	transcripts	transcript	NNS
cord-002530-ao7kenbx	315	29	and	and	CC
cord-002530-ao7kenbx	315	30	at	at	IN
cord-002530-ao7kenbx	315	31	later	later	JJ
cord-002530-ao7kenbx	315	32	times	time	NNS
cord-002530-ao7kenbx	315	33	for	for	IN
cord-002530-ao7kenbx	315	34	virus	virus	NN
cord-002530-ao7kenbx	315	35	production	production	NN
cord-002530-ao7kenbx	315	36	We	-PRON-	PRP
cord-002530-ao7kenbx	315	37	would	would	MD
cord-002530-ao7kenbx	315	38	like	like	VB
cord-002530-ao7kenbx	315	39	to	to	TO
cord-002530-ao7kenbx	315	40	acknowledge	acknowledge	VB
cord-002530-ao7kenbx	315	41	Paul	Paul	NNP
cord-002530-ao7kenbx	315	42	Digard	Digard	NNP
cord-002530-ao7kenbx	315	43	,	,	,
cord-002530-ao7kenbx	315	44	Jay	Jay	NNP
cord-002530-ao7kenbx	315	45	Nelson	Nelson	NNP
cord-002530-ao7kenbx	315	46	and	and	CC
cord-002530-ao7kenbx	315	47	Christopher	Christopher	NNP
cord-002530-ao7kenbx	315	48	Snyder	Snyder	NNP
cord-002530-ao7kenbx	315	49	for	for	IN
cord-002530-ao7kenbx	315	50	critical	critical	JJ
cord-002530-ao7kenbx	315	51	review	review	NN
cord-002530-ao7kenbx	315	52	of	of	IN
cord-002530-ao7kenbx	315	53	the	the	DT
cord-002530-ao7kenbx	315	54	manuscript	manuscript	NN
cord-002530-ao7kenbx	315	55	and	and	CC
cord-002530-ao7kenbx	315	56	Steve	Steve	NNP
cord-002530-ao7kenbx	315	57	West	West	NNP
cord-002530-ao7kenbx	315	58	and	and	CC
cord-002530-ao7kenbx	315	59	Greg	Greg	NNP
cord-002530-ao7kenbx	315	60	Kudla	Kudla	NNP
cord-002530-ao7kenbx	315	61	for	for	IN
cord-002530-ao7kenbx	315	62	helpful	helpful	JJ
cord-002530-ao7kenbx	315	63	discussion	discussion	NN
cord-002530-ao7kenbx	315	64	.	.	.
cord-002530-ao7kenbx	316	1	RNAseq	RNAseq	NNP
cord-002530-ao7kenbx	316	2	was	be	VBD
cord-002530-ao7kenbx	316	3	performed	perform	VBN
cord-002530-ao7kenbx	316	4	by	by	IN
cord-002530-ao7kenbx	316	5	Edinburgh	Edinburgh	NNP
cord-002530-ao7kenbx	316	6	Genomics	Genomics	NNP
cord-002530-ao7kenbx	316	7	,	,	,
cord-002530-ao7kenbx	316	8	The	the	DT
cord-002530-ao7kenbx	316	9	University	University	NNP
cord-002530-ao7kenbx	316	10	of	of	IN
cord-002530-ao7kenbx	316	11	Edinburgh	Edinburgh	NNP
cord-002530-ao7kenbx	316	12	.	.	.
cord-002530-ao7kenbx	317	1	Ahn	Ahn	NNP
cord-002530-ao7kenbx	317	2	JH	JH	NNP
cord-002530-ao7kenbx	317	3	,	,	,
cord-002530-ao7kenbx	317	4	Jang	Jang	NNP
cord-002530-ao7kenbx	317	5	WJ	WJ	NNP
cord-002530-ao7kenbx	317	6	,	,	,
cord-002530-ao7kenbx	317	7	Hayward	Hayward	NNP
cord-002530-ao7kenbx	317	8	GS	GS	NNP
cord-002530-ao7kenbx	317	9	(	(	-LRB-
cord-002530-ao7kenbx	317	10	1999	1999	CD
cord-002530-ao7kenbx	317	11	)	)	-RRB-
cord-002530-ao7kenbx	318	1	The	the	DT
cord-002530-ao7kenbx	318	2	human	human	JJ
cord-002530-ao7kenbx	318	3	cytomegalovirus	cytomegalovirus	NN
cord-002530-ao7kenbx	318	4	IE2	ie2	NN
cord-002530-ao7kenbx	318	5	and	and	CC
cord-002530-ao7kenbx	318	6	UL112	UL112	NNP
cord-002530-ao7kenbx	318	7	-	-	HYPH
cord-002530-ao7kenbx	318	8	113	113	CD
cord-002530-ao7kenbx	318	9	proteins	protein	NNS
cord-002530-ao7kenbx	318	10	accumulate	accumulate	VBP
cord-002530-ao7kenbx	318	11	in	in	IN
cord-002530-ao7kenbx	318	12	viral	viral	JJ
cord-002530-ao7kenbx	318	13	DNA	dna	NN
cord-002530-ao7kenbx	318	14	replication	replication	NN
cord-002530-ao7kenbx	318	15	compartments	compartment	NNS
cord-002530-ao7kenbx	318	16	that	that	WDT
cord-002530-ao7kenbx	318	17	initiate	initiate	VBP
cord-002530-ao7kenbx	318	18	from	from	IN
cord-002530-ao7kenbx	318	19	the	the	DT
cord-002530-ao7kenbx	318	20	periphery	periphery	NN
cord-002530-ao7kenbx	318	21	of	of	IN
cord-002530-ao7kenbx	318	22	promyelocytic	promyelocytic	JJ
cord-002530-ao7kenbx	318	23	leukemia	leukemia	NN
cord-002530-ao7kenbx	318	24	protein	protein	NN
cord-002530-ao7kenbx	318	25	-	-	HYPH
cord-002530-ao7kenbx	318	26	associated	associate	VBN
cord-002530-ao7kenbx	318	27	nuclear	nuclear	JJ
cord-002530-ao7kenbx	318	28	bodies	body	NNS
cord-002530-ao7kenbx	318	29	(	(	-LRB-
cord-002530-ao7kenbx	318	30	PODs	pod	NNS
cord-002530-ao7kenbx	318	31	or	or	CC
cord-002530-ao7kenbx	318	32	ND10	ND10	NNP
cord-002530-ao7kenbx	318	33	 	 	_SP