id sid tid token lemma pos cord-262248-q5eijunp 1 1 key key JJ cord-262248-q5eijunp 1 2 : : : cord-262248-q5eijunp 1 3 cord-262248-q5eijunp cord-262248-q5eijunp NN cord-262248-q5eijunp 1 4 authors author NNS cord-262248-q5eijunp 1 5 : : : cord-262248-q5eijunp 1 6 Casadevall Casadevall NNP cord-262248-q5eijunp 1 7 , , , cord-262248-q5eijunp 1 8 Arturo Arturo NNP cord-262248-q5eijunp 1 9 ; ; : cord-262248-q5eijunp 1 10 Pirofski Pirofski NNP cord-262248-q5eijunp 1 11 , , , cord-262248-q5eijunp 1 12 Liise Liise NNP cord-262248-q5eijunp 1 13 - - HYPH cord-262248-q5eijunp 1 14 anne anne NNP cord-262248-q5eijunp 1 15 title title NN cord-262248-q5eijunp 1 16 : : : cord-262248-q5eijunp 2 1 The the DT cord-262248-q5eijunp 2 2 Ebola Ebola NNP cord-262248-q5eijunp 2 3 Epidemic epidemic NN cord-262248-q5eijunp 2 4 Crystallizes crystallize VBZ cord-262248-q5eijunp 2 5 the the DT cord-262248-q5eijunp 2 6 Potential potential NN cord-262248-q5eijunp 2 7 of of IN cord-262248-q5eijunp 2 8 Passive Passive NNP cord-262248-q5eijunp 2 9 Antibody Antibody NNP cord-262248-q5eijunp 2 10 Therapy Therapy NNP cord-262248-q5eijunp 2 11 for for IN cord-262248-q5eijunp 2 12 Infectious Infectious NNP cord-262248-q5eijunp 2 13 Diseases Diseases NNPS cord-262248-q5eijunp 2 14 date date NN cord-262248-q5eijunp 3 1 : : : cord-262248-q5eijunp 3 2 2015 2015 CD cord-262248-q5eijunp 3 3 - - HYPH cord-262248-q5eijunp 3 4 04 04 CD cord-262248-q5eijunp 3 5 - - HYPH cord-262248-q5eijunp 3 6 23 23 CD cord-262248-q5eijunp 3 7 journal journal NN cord-262248-q5eijunp 3 8 : : : cord-262248-q5eijunp 4 1 PLoS PLoS NNP cord-262248-q5eijunp 4 2 Pathog Pathog NNP cord-262248-q5eijunp 4 3 DOI DOI NNP cord-262248-q5eijunp 4 4 : : : cord-262248-q5eijunp 5 1 10.1371 10.1371 CD cord-262248-q5eijunp 5 2 / / SYM cord-262248-q5eijunp 5 3 journal.ppat.1004717 journal.ppat.1004717 NNP cord-262248-q5eijunp 5 4 sha sha NNP cord-262248-q5eijunp 5 5 : : : cord-262248-q5eijunp 6 1 f74ee87b0db54450d2684da633a56b6f159a6c0b f74ee87b0db54450d2684da633a56b6f159a6c0b NNP cord-262248-q5eijunp 6 2 doc_id doc_id CD cord-262248-q5eijunp 6 3 : : : cord-262248-q5eijunp 6 4 262248 262248 CD cord-262248-q5eijunp 6 5 cord_uid cord_uid NNS cord-262248-q5eijunp 6 6 : : : cord-262248-q5eijunp 7 1 q5eijunp q5eijunp NNP cord-262248-q5eijunp 7 2 nan nan NNP cord-262248-q5eijunp 8 1 In in IN cord-262248-q5eijunp 8 2 2014 2014 CD cord-262248-q5eijunp 8 3 , , , cord-262248-q5eijunp 8 4 an an DT cord-262248-q5eijunp 8 5 Ebola Ebola NNP cord-262248-q5eijunp 8 6 virus virus NN cord-262248-q5eijunp 8 7 epidemic epidemic NN cord-262248-q5eijunp 8 8 began begin VBD cord-262248-q5eijunp 8 9 in in IN cord-262248-q5eijunp 8 10 West West NNP cord-262248-q5eijunp 8 11 Africa Africa NNP cord-262248-q5eijunp 8 12 and and CC cord-262248-q5eijunp 8 13 it -PRON- PRP cord-262248-q5eijunp 8 14 has have VBZ cord-262248-q5eijunp 8 15 affected affect VBN cord-262248-q5eijunp 8 16 over over IN cord-262248-q5eijunp 8 17 17,000 17,000 CD cord-262248-q5eijunp 8 18 individuals individual NNS cord-262248-q5eijunp 8 19 [ [ -LRB- cord-262248-q5eijunp 8 20 2 2 CD cord-262248-q5eijunp 8 21 ] ] -RRB- cord-262248-q5eijunp 8 22 . . . cord-262248-q5eijunp 9 1 Unlike unlike IN cord-262248-q5eijunp 9 2 earlier early JJR cord-262248-q5eijunp 9 3 Ebola Ebola NNP cord-262248-q5eijunp 9 4 outbreaks outbreak NNS cord-262248-q5eijunp 9 5 that that WDT cord-262248-q5eijunp 9 6 were be VBD cord-262248-q5eijunp 9 7 largely largely RB cord-262248-q5eijunp 9 8 confined confine VBN cord-262248-q5eijunp 9 9 to to IN cord-262248-q5eijunp 9 10 isolated isolate VBN cord-262248-q5eijunp 9 11 villages village NNS cord-262248-q5eijunp 9 12 , , , cord-262248-q5eijunp 9 13 this this DT cord-262248-q5eijunp 9 14 one one NN cord-262248-q5eijunp 9 15 struck strike VBD cord-262248-q5eijunp 9 16 in in IN cord-262248-q5eijunp 9 17 populated populated JJ cord-262248-q5eijunp 9 18 cities city NNS cord-262248-q5eijunp 9 19 and and CC cord-262248-q5eijunp 9 20 was be VBD cord-262248-q5eijunp 9 21 sustained sustain VBN cord-262248-q5eijunp 9 22 through through IN cord-262248-q5eijunp 9 23 person person NN cord-262248-q5eijunp 9 24 - - HYPH cord-262248-q5eijunp 9 25 to to IN cord-262248-q5eijunp 9 26 - - HYPH cord-262248-q5eijunp 9 27 person person NN cord-262248-q5eijunp 9 28 transmission transmission NN cord-262248-q5eijunp 9 29 . . . cord-262248-q5eijunp 10 1 At at IN cord-262248-q5eijunp 10 2 the the DT cord-262248-q5eijunp 10 3 end end NN cord-262248-q5eijunp 10 4 of of IN cord-262248-q5eijunp 10 5 2014 2014 CD cord-262248-q5eijunp 10 6 , , , cord-262248-q5eijunp 10 7 the the DT cord-262248-q5eijunp 10 8 epidemic epidemic NN cord-262248-q5eijunp 10 9 remained remain VBD cord-262248-q5eijunp 10 10 uncontrolled uncontrolled JJ cord-262248-q5eijunp 10 11 [ [ -LRB- cord-262248-q5eijunp 10 12 2 2 CD cord-262248-q5eijunp 10 13 ] ] -RRB- cord-262248-q5eijunp 10 14 . . . cord-262248-q5eijunp 11 1 Currently currently RB cord-262248-q5eijunp 11 2 , , , cord-262248-q5eijunp 11 3 there there EX cord-262248-q5eijunp 11 4 are be VBP cord-262248-q5eijunp 11 5 no no DT cord-262248-q5eijunp 11 6 drugs drug NNS cord-262248-q5eijunp 11 7 to to TO cord-262248-q5eijunp 11 8 treat treat VB cord-262248-q5eijunp 11 9 Ebola Ebola NNP cord-262248-q5eijunp 11 10 , , , cord-262248-q5eijunp 11 11 but but CC cord-262248-q5eijunp 11 12 , , , cord-262248-q5eijunp 11 13 in in IN cord-262248-q5eijunp 11 14 the the DT cord-262248-q5eijunp 11 15 urgency urgency NN cord-262248-q5eijunp 11 16 and and CC cord-262248-q5eijunp 11 17 emergency emergency NN cord-262248-q5eijunp 11 18 triggered trigger VBN cord-262248-q5eijunp 11 19 by by IN cord-262248-q5eijunp 11 20 the the DT cord-262248-q5eijunp 11 21 epidemic epidemic NN cord-262248-q5eijunp 11 22 , , , cord-262248-q5eijunp 11 23 two two CD cord-262248-q5eijunp 11 24 types type NNS cord-262248-q5eijunp 11 25 of of IN cord-262248-q5eijunp 11 26 Ab ab NN cord-262248-q5eijunp 11 27 - - HYPH cord-262248-q5eijunp 11 28 based base VBN cord-262248-q5eijunp 11 29 therapies therapy NNS cord-262248-q5eijunp 11 30 have have VBP cord-262248-q5eijunp 11 31 been be VBN cord-262248-q5eijunp 11 32 used use VBN cord-262248-q5eijunp 11 33 : : : cord-262248-q5eijunp 11 34 convalescent convalescent JJ cord-262248-q5eijunp 11 35 sera sera NNP cord-262248-q5eijunp 11 36 from from IN cord-262248-q5eijunp 11 37 patients patient NNS cord-262248-q5eijunp 11 38 who who WP cord-262248-q5eijunp 11 39 have have VBP cord-262248-q5eijunp 11 40 recovered recover VBN cord-262248-q5eijunp 11 41 and and CC cord-262248-q5eijunp 11 42 a a DT cord-262248-q5eijunp 11 43 mAb mab NN cord-262248-q5eijunp 11 44 cocktail cocktail NN cord-262248-q5eijunp 11 45 known know VBN cord-262248-q5eijunp 11 46 as as IN cord-262248-q5eijunp 11 47 ZMapp ZMapp NNP cord-262248-q5eijunp 11 48 produced produce VBD cord-262248-q5eijunp 11 49 in in IN cord-262248-q5eijunp 11 50 plants plant NNS cord-262248-q5eijunp 11 51 [ [ -LRB- cord-262248-q5eijunp 11 52 3 3 CD cord-262248-q5eijunp 11 53 ] ] -RRB- cord-262248-q5eijunp 11 54 . . . cord-262248-q5eijunp 12 1 Although although IN cord-262248-q5eijunp 12 2 at at IN cord-262248-q5eijunp 12 3 the the DT cord-262248-q5eijunp 12 4 time time NN cord-262248-q5eijunp 12 5 of of IN cord-262248-q5eijunp 12 6 this this DT cord-262248-q5eijunp 12 7 writing write VBG cord-262248-q5eijunp 12 8 the the DT cord-262248-q5eijunp 12 9 news news NN cord-262248-q5eijunp 12 10 releases release NNS cord-262248-q5eijunp 12 11 on on IN cord-262248-q5eijunp 12 12 the the DT cord-262248-q5eijunp 12 13 efficacy efficacy NN cord-262248-q5eijunp 12 14 of of IN cord-262248-q5eijunp 12 15 Ab ab NN cord-262248-q5eijunp 12 16 - - HYPH cord-262248-q5eijunp 12 17 based base VBN cord-262248-q5eijunp 12 18 therapies therapy NNS cord-262248-q5eijunp 12 19 have have VBP cord-262248-q5eijunp 12 20 been be VBN cord-262248-q5eijunp 12 21 largely largely RB cord-262248-q5eijunp 12 22 favorable favorable JJ cord-262248-q5eijunp 12 23 , , , cord-262248-q5eijunp 12 24 the the DT cord-262248-q5eijunp 12 25 evidence evidence NN cord-262248-q5eijunp 12 26 is be VBZ cord-262248-q5eijunp 12 27 anecdotal anecdotal JJ cord-262248-q5eijunp 12 28 and and CC cord-262248-q5eijunp 12 29 firm firm JJ cord-262248-q5eijunp 12 30 conclusions conclusion NNS cord-262248-q5eijunp 12 31 can can MD cord-262248-q5eijunp 12 32 not not RB cord-262248-q5eijunp 12 33 be be VB cord-262248-q5eijunp 12 34 made make VBN cord-262248-q5eijunp 12 35 until until IN cord-262248-q5eijunp 12 36 formal formal JJ cord-262248-q5eijunp 12 37 clinical clinical JJ cord-262248-q5eijunp 12 38 trials trial NNS cord-262248-q5eijunp 12 39 are be VBP cord-262248-q5eijunp 12 40 done do VBN cord-262248-q5eijunp 12 41 , , , cord-262248-q5eijunp 12 42 such such JJ cord-262248-q5eijunp 12 43 as as IN cord-262248-q5eijunp 12 44 those those DT cord-262248-q5eijunp 12 45 encouraged encourage VBN cord-262248-q5eijunp 12 46 by by IN cord-262248-q5eijunp 12 47 the the DT cord-262248-q5eijunp 12 48 World World NNP cord-262248-q5eijunp 12 49 Health Health NNP cord-262248-q5eijunp 12 50 Organization Organization NNP cord-262248-q5eijunp 12 51 [ [ -LRB- cord-262248-q5eijunp 12 52 4 4 CD cord-262248-q5eijunp 12 53 ] ] -RRB- cord-262248-q5eijunp 12 54 . . . cord-262248-q5eijunp 13 1 Therefore therefore RB cord-262248-q5eijunp 13 2 , , , cord-262248-q5eijunp 13 3 we -PRON- PRP cord-262248-q5eijunp 13 4 will will MD cord-262248-q5eijunp 13 5 refrain refrain VB cord-262248-q5eijunp 13 6 from from IN cord-262248-q5eijunp 13 7 commenting comment VBG cord-262248-q5eijunp 13 8 on on IN cord-262248-q5eijunp 13 9 the the DT cord-262248-q5eijunp 13 10 efficacy efficacy NN cord-262248-q5eijunp 13 11 of of IN cord-262248-q5eijunp 13 12 Ab Ab NNP cord-262248-q5eijunp 13 13 therapies therapy NNS cord-262248-q5eijunp 13 14 against against IN cord-262248-q5eijunp 13 15 Ebola Ebola NNP cord-262248-q5eijunp 13 16 virus virus NN cord-262248-q5eijunp 13 17 and and CC cord-262248-q5eijunp 13 18 will will MD cord-262248-q5eijunp 13 19 focus focus VB cord-262248-q5eijunp 13 20 , , , cord-262248-q5eijunp 13 21 instead instead RB cord-262248-q5eijunp 13 22 , , , cord-262248-q5eijunp 13 23 on on IN cord-262248-q5eijunp 13 24 how how WRB cord-262248-q5eijunp 13 25 this this DT cord-262248-q5eijunp 13 26 concurrent concurrent JJ cord-262248-q5eijunp 13 27 epidemic epidemic NN cord-262248-q5eijunp 13 28 brings bring VBZ cord-262248-q5eijunp 13 29 into into IN cord-262248-q5eijunp 13 30 focus focus NN cord-262248-q5eijunp 13 31 the the DT cord-262248-q5eijunp 13 32 promise promise NN cord-262248-q5eijunp 13 33 of of IN cord-262248-q5eijunp 13 34 this this DT cord-262248-q5eijunp 13 35 therapy therapy NN cord-262248-q5eijunp 13 36 while while IN cord-262248-q5eijunp 13 37 also also RB cord-262248-q5eijunp 13 38 highlighting highlight VBG cord-262248-q5eijunp 13 39 the the DT cord-262248-q5eijunp 13 40 difficulties difficulty NNS cord-262248-q5eijunp 13 41 involved involve VBN cord-262248-q5eijunp 13 42 in in IN cord-262248-q5eijunp 13 43 reintroducing reintroduce VBG cord-262248-q5eijunp 13 44 antibodies antibody NNS cord-262248-q5eijunp 13 45 for for IN cord-262248-q5eijunp 13 46 the the DT cord-262248-q5eijunp 13 47 therapy therapy NN cord-262248-q5eijunp 13 48 of of IN cord-262248-q5eijunp 13 49 infectious infectious JJ cord-262248-q5eijunp 13 50 diseases disease NNS cord-262248-q5eijunp 13 51 . . . cord-262248-q5eijunp 14 1 Antibodies antibody NNS cord-262248-q5eijunp 14 2 are be VBP cord-262248-q5eijunp 14 3 molecules molecule NNS cord-262248-q5eijunp 14 4 that that WDT cord-262248-q5eijunp 14 5 can can MD cord-262248-q5eijunp 14 6 exert exert VB cord-262248-q5eijunp 14 7 antimicrobial antimicrobial JJ cord-262248-q5eijunp 14 8 activity activity NN cord-262248-q5eijunp 14 9 through through IN cord-262248-q5eijunp 14 10 different different JJ cord-262248-q5eijunp 14 11 mechanisms mechanism NNS cord-262248-q5eijunp 14 12 that that WDT cord-262248-q5eijunp 14 13 include include VBP cord-262248-q5eijunp 14 14 promoting promote VBG cord-262248-q5eijunp 14 15 phagocytosis phagocytosis NN cord-262248-q5eijunp 14 16 and and CC cord-262248-q5eijunp 14 17 Ab ab NN cord-262248-q5eijunp 14 18 - - HYPH cord-262248-q5eijunp 14 19 dependent dependent JJ cord-262248-q5eijunp 14 20 cellular cellular JJ cord-262248-q5eijunp 14 21 cytotoxicity cytotoxicity NN cord-262248-q5eijunp 14 22 ( ( -LRB- cord-262248-q5eijunp 14 23 ADCC ADCC NNP cord-262248-q5eijunp 14 24 ) ) -RRB- cord-262248-q5eijunp 14 25 , , , cord-262248-q5eijunp 14 26 activating activate VBG cord-262248-q5eijunp 14 27 complement complement NN cord-262248-q5eijunp 14 28 , , , cord-262248-q5eijunp 14 29 neutralizing neutralize VBG cord-262248-q5eijunp 14 30 viruses virus NNS cord-262248-q5eijunp 14 31 and and CC cord-262248-q5eijunp 14 32 toxins toxin NNS cord-262248-q5eijunp 14 33 , , , cord-262248-q5eijunp 14 34 modulating modulate VBG cord-262248-q5eijunp 14 35 inflammation inflammation NN cord-262248-q5eijunp 14 36 , , , cord-262248-q5eijunp 14 37 and and CC cord-262248-q5eijunp 14 38 affecting affect VBG cord-262248-q5eijunp 14 39 microbial microbial JJ cord-262248-q5eijunp 14 40 metabolism metabolism NN cord-262248-q5eijunp 14 41 ( ( -LRB- cord-262248-q5eijunp 14 42 reviewed review VBN cord-262248-q5eijunp 14 43 in in IN cord-262248-q5eijunp 14 44 [ [ -LRB- cord-262248-q5eijunp 14 45 5 5 CD cord-262248-q5eijunp 14 46 ] ] -RRB- cord-262248-q5eijunp 14 47 ) ) -RRB- cord-262248-q5eijunp 14 48 . . . cord-262248-q5eijunp 15 1 This this DT cord-262248-q5eijunp 15 2 diversity diversity NN cord-262248-q5eijunp 15 3 of of IN cord-262248-q5eijunp 15 4 function function NN cord-262248-q5eijunp 15 5 makes make VBZ cord-262248-q5eijunp 15 6 it -PRON- PRP cord-262248-q5eijunp 15 7 possible possible JJ cord-262248-q5eijunp 15 8 to to TO cord-262248-q5eijunp 15 9 tailor tailor VB cord-262248-q5eijunp 15 10 Ab Ab NNP cord-262248-q5eijunp 15 11 therapies therapy NNS cord-262248-q5eijunp 15 12 to to IN cord-262248-q5eijunp 15 13 specific specific JJ cord-262248-q5eijunp 15 14 diseases disease NNS cord-262248-q5eijunp 15 15 depending depend VBG cord-262248-q5eijunp 15 16 on on IN cord-262248-q5eijunp 15 17 what what WP cord-262248-q5eijunp 15 18 might may MD cord-262248-q5eijunp 15 19 be be VB cord-262248-q5eijunp 15 20 needed need VBN cord-262248-q5eijunp 15 21 for for IN cord-262248-q5eijunp 15 22 protection protection NN cord-262248-q5eijunp 15 23 . . . cord-262248-q5eijunp 16 1 For for IN cord-262248-q5eijunp 16 2 example example NN cord-262248-q5eijunp 16 3 , , , cord-262248-q5eijunp 16 4 antibodies antibody NNS cord-262248-q5eijunp 16 5 overcome overcome VBP cord-262248-q5eijunp 16 6 the the DT cord-262248-q5eijunp 16 7 anti anti JJ cord-262248-q5eijunp 16 8 - - JJ cord-262248-q5eijunp 16 9 phagocytic phagocytic JJ cord-262248-q5eijunp 16 10 properties property NNS cord-262248-q5eijunp 16 11 of of IN cord-262248-q5eijunp 16 12 encapsulated encapsulate VBN cord-262248-q5eijunp 16 13 microbes microbe NNS cord-262248-q5eijunp 16 14 , , , cord-262248-q5eijunp 16 15 such such JJ cord-262248-q5eijunp 16 16 as as IN cord-262248-q5eijunp 16 17 Streptococcus streptococcus NN cord-262248-q5eijunp 16 18 pneumoniae pneumoniae NN cord-262248-q5eijunp 16 19 and and CC cord-262248-q5eijunp 16 20 Cryptococcus Cryptococcus NNP cord-262248-q5eijunp 16 21 neoformans neoforman VBZ cord-262248-q5eijunp 16 22 , , , cord-262248-q5eijunp 16 23 by by IN cord-262248-q5eijunp 16 24 promoting promote VBG cord-262248-q5eijunp 16 25 phagocytosis phagocytosis NN cord-262248-q5eijunp 16 26 through through IN cord-262248-q5eijunp 16 27 Fc Fc NNP cord-262248-q5eijunp 16 28 receptors receptor NNS cord-262248-q5eijunp 16 29 while while IN cord-262248-q5eijunp 16 30 the the DT cord-262248-q5eijunp 16 31 toxin toxin NN cord-262248-q5eijunp 16 32 - - HYPH cord-262248-q5eijunp 16 33 neutralizing neutralize VBG cord-262248-q5eijunp 16 34 properties property NNS cord-262248-q5eijunp 16 35 inhibit inhibit VBP cord-262248-q5eijunp 16 36 the the DT cord-262248-q5eijunp 16 37 deleterious deleterious JJ cord-262248-q5eijunp 16 38 effects effect NNS cord-262248-q5eijunp 16 39 of of IN cord-262248-q5eijunp 16 40 toxigenic toxigenic NNP cord-262248-q5eijunp 16 41 bacteria bacteria NNS cord-262248-q5eijunp 16 42 , , , cord-262248-q5eijunp 16 43 such such JJ cord-262248-q5eijunp 16 44 as as IN cord-262248-q5eijunp 16 45 Bacillus Bacillus NNP cord-262248-q5eijunp 16 46 anthracis anthracis NN cord-262248-q5eijunp 16 47 . . . cord-262248-q5eijunp 17 1 The the DT cord-262248-q5eijunp 17 2 versatility versatility NN cord-262248-q5eijunp 17 3 associated associate VBN cord-262248-q5eijunp 17 4 with with IN cord-262248-q5eijunp 17 5 Ab Ab NNP cord-262248-q5eijunp 17 6 therapies therapy NNS cord-262248-q5eijunp 17 7 is be VBZ cord-262248-q5eijunp 17 8 further far RBR cord-262248-q5eijunp 17 9 amplified amplify VBN cord-262248-q5eijunp 17 10 by by IN cord-262248-q5eijunp 17 11 the the DT cord-262248-q5eijunp 17 12 availability availability NN cord-262248-q5eijunp 17 13 of of IN cord-262248-q5eijunp 17 14 different different JJ cord-262248-q5eijunp 17 15 isotypes isotype NNS cord-262248-q5eijunp 17 16 that that WDT cord-262248-q5eijunp 17 17 differ differ VBP cord-262248-q5eijunp 17 18 in in IN cord-262248-q5eijunp 17 19 serum serum NN cord-262248-q5eijunp 17 20 half half JJ cord-262248-q5eijunp 17 21 - - HYPH cord-262248-q5eijunp 17 22 life life NN cord-262248-q5eijunp 17 23 and and CC cord-262248-q5eijunp 17 24 effector effector NN cord-262248-q5eijunp 17 25 function function NN cord-262248-q5eijunp 17 26 , , , cord-262248-q5eijunp 17 27 with with IN cord-262248-q5eijunp 17 28 the the DT cord-262248-q5eijunp 17 29 latter latter JJ cord-262248-q5eijunp 17 30 partially partially RB cord-262248-q5eijunp 17 31 dependent dependent JJ cord-262248-q5eijunp 17 32 on on IN cord-262248-q5eijunp 17 33 Fc Fc NNP cord-262248-q5eijunp 17 34 receptors receptor NNS cord-262248-q5eijunp 17 35 ( ( -LRB- cord-262248-q5eijunp 17 36 FcR FcR NNP cord-262248-q5eijunp 17 37 ) ) -RRB- cord-262248-q5eijunp 17 38 that that WDT cord-262248-q5eijunp 17 39 can can MD cord-262248-q5eijunp 17 40 amplify amplify VB cord-262248-q5eijunp 17 41 or or CC cord-262248-q5eijunp 17 42 reduce reduce VB cord-262248-q5eijunp 17 43 inflammatory inflammatory JJ cord-262248-q5eijunp 17 44 responses response NNS cord-262248-q5eijunp 17 45 . . . cord-262248-q5eijunp 18 1 In in IN cord-262248-q5eijunp 18 2 this this DT cord-262248-q5eijunp 18 3 regard regard NN cord-262248-q5eijunp 18 4 , , , cord-262248-q5eijunp 18 5 the the DT cord-262248-q5eijunp 18 6 efficacy efficacy NN cord-262248-q5eijunp 18 7 of of IN cord-262248-q5eijunp 18 8 broadly broadly RB cord-262248-q5eijunp 18 9 neutralizing neutralize VBG cord-262248-q5eijunp 18 10 antibodies antibody NNS cord-262248-q5eijunp 18 11 to to IN cord-262248-q5eijunp 18 12 HIV HIV NNP cord-262248-q5eijunp 18 13 is be VBZ cord-262248-q5eijunp 18 14 dependent dependent JJ cord-262248-q5eijunp 18 15 on on IN cord-262248-q5eijunp 18 16 FcRs FcRs NNP cord-262248-q5eijunp 18 17 [ [ -LRB- cord-262248-q5eijunp 18 18 6 6 CD cord-262248-q5eijunp 18 19 ] ] -RRB- cord-262248-q5eijunp 18 20 and and CC cord-262248-q5eijunp 18 21 vaccine vaccine NN cord-262248-q5eijunp 18 22 - - HYPH cord-262248-q5eijunp 18 23 elicited elicit VBN cord-262248-q5eijunp 18 24 subclass subclass NN cord-262248-q5eijunp 18 25 selection selection NN cord-262248-q5eijunp 18 26 , , , cord-262248-q5eijunp 18 27 which which WDT cord-262248-q5eijunp 18 28 could could MD cord-262248-q5eijunp 18 29 drive drive VB cord-262248-q5eijunp 18 30 optimal optimal JJ cord-262248-q5eijunp 18 31 FcR fcr NN cord-262248-q5eijunp 18 32 effector effector NN cord-262248-q5eijunp 18 33 function function NN cord-262248-q5eijunp 18 34 of of IN cord-262248-q5eijunp 18 35 non non JJ cord-262248-q5eijunp 18 36 - - JJ cord-262248-q5eijunp 18 37 neutralizing neutralize VBG cord-262248-q5eijunp 18 38 antibodies antibody NNS cord-262248-q5eijunp 18 39 against against IN cord-262248-q5eijunp 18 40 HIV HIV NNP cord-262248-q5eijunp 18 41 [ [ -LRB- cord-262248-q5eijunp 18 42 7 7 CD cord-262248-q5eijunp 18 43 ] ] -RRB- cord-262248-q5eijunp 18 44 . . . cord-262248-q5eijunp 19 1 Although although IN cord-262248-q5eijunp 19 2 several several JJ cord-262248-q5eijunp 19 3 types type NNS cord-262248-q5eijunp 19 4 of of IN cord-262248-q5eijunp 19 5 Ab Ab NNP cord-262248-q5eijunp 19 6 therapies therapy NNS cord-262248-q5eijunp 19 7 have have VBP cord-262248-q5eijunp 19 8 been be VBN cord-262248-q5eijunp 19 9 highly highly RB cord-262248-q5eijunp 19 10 successful successful JJ cord-262248-q5eijunp 19 11 , , , cord-262248-q5eijunp 19 12 it -PRON- PRP cord-262248-q5eijunp 19 13 is be VBZ cord-262248-q5eijunp 19 14 noteworthy noteworthy JJ cord-262248-q5eijunp 19 15 that that IN cord-262248-q5eijunp 19 16 , , , cord-262248-q5eijunp 19 17 to to IN cord-262248-q5eijunp 19 18 date date NN cord-262248-q5eijunp 19 19 , , , cord-262248-q5eijunp 19 20 available available JJ cord-262248-q5eijunp 19 21 therapies therapy NNS cord-262248-q5eijunp 19 22 have have VBP cord-262248-q5eijunp 19 23 not not RB cord-262248-q5eijunp 19 24 taken take VBN cord-262248-q5eijunp 19 25 full full JJ cord-262248-q5eijunp 19 26 advantage advantage NN cord-262248-q5eijunp 19 27 of of IN cord-262248-q5eijunp 19 28 either either CC cord-262248-q5eijunp 19 29 Ab Ab NNP cord-262248-q5eijunp 19 30 or or CC cord-262248-q5eijunp 19 31 FcR fcr VB cord-262248-q5eijunp 19 32 structural structural JJ cord-262248-q5eijunp 19 33 and and CC cord-262248-q5eijunp 19 34 functional functional JJ cord-262248-q5eijunp 19 35 diversity diversity NN cord-262248-q5eijunp 19 36 . . . cord-262248-q5eijunp 20 1 Historically historically RB cord-262248-q5eijunp 20 2 , , , cord-262248-q5eijunp 20 3 Ab Ab NNP cord-262248-q5eijunp 20 4 preparations preparation NNS cord-262248-q5eijunp 20 5 for for IN cord-262248-q5eijunp 20 6 therapy therapy NN cord-262248-q5eijunp 20 7 were be VBD cord-262248-q5eijunp 20 8 obtained obtain VBN cord-262248-q5eijunp 20 9 by by IN cord-262248-q5eijunp 20 10 immunizing immunize VBG cord-262248-q5eijunp 20 11 animals animal NNS cord-262248-q5eijunp 20 12 or or CC cord-262248-q5eijunp 20 13 from from IN cord-262248-q5eijunp 20 14 recovered recover VBN cord-262248-q5eijunp 20 15 individuals individual NNS cord-262248-q5eijunp 20 16 as as IN cord-262248-q5eijunp 20 17 convalescent convalescent JJ cord-262248-q5eijunp 20 18 sera sera NNP cord-262248-q5eijunp 20 19 . . . cord-262248-q5eijunp 21 1 Serum serum NN cord-262248-q5eijunp 21 2 therapy therapy NN cord-262248-q5eijunp 21 3 for for IN cord-262248-q5eijunp 21 4 pneumococcus pneumococcus NNP cord-262248-q5eijunp 21 5 relied rely VBD cord-262248-q5eijunp 21 6 largely largely RB cord-262248-q5eijunp 21 7 on on IN cord-262248-q5eijunp 21 8 horse horse NN cord-262248-q5eijunp 21 9 immune immune JJ cord-262248-q5eijunp 21 10 serum serum NN cord-262248-q5eijunp 21 11 . . . cord-262248-q5eijunp 22 1 Animal Animal NNP cord-262248-q5eijunp 22 2 sera sera NNP cord-262248-q5eijunp 22 3 were be VBD cord-262248-q5eijunp 22 4 effective effective JJ cord-262248-q5eijunp 22 5 , , , cord-262248-q5eijunp 22 6 but but CC cord-262248-q5eijunp 22 7 they -PRON- PRP cord-262248-q5eijunp 22 8 could could MD cord-262248-q5eijunp 22 9 also also RB cord-262248-q5eijunp 22 10 elicit elicit VB cord-262248-q5eijunp 22 11 allergic allergic JJ cord-262248-q5eijunp 22 12 reactions reaction NNS cord-262248-q5eijunp 22 13 or or CC cord-262248-q5eijunp 22 14 the the DT cord-262248-q5eijunp 22 15 phenomenon phenomenon NN cord-262248-q5eijunp 22 16 of of IN cord-262248-q5eijunp 22 17 " " `` cord-262248-q5eijunp 22 18 serum serum NN cord-262248-q5eijunp 22 19 sickness sickness NN cord-262248-q5eijunp 22 20 . . . cord-262248-q5eijunp 22 21 " " '' cord-262248-q5eijunp 23 1 Human human JJ cord-262248-q5eijunp 23 2 convalescent convalescent NN cord-262248-q5eijunp 23 3 sera sera NNP cord-262248-q5eijunp 23 4 were be VBD cord-262248-q5eijunp 23 5 used use VBN cord-262248-q5eijunp 23 6 for for IN cord-262248-q5eijunp 23 7 viral viral JJ cord-262248-q5eijunp 23 8 diseases disease NNS cord-262248-q5eijunp 23 9 specific specific JJ cord-262248-q5eijunp 23 10 to to IN cord-262248-q5eijunp 23 11 humans human NNS cord-262248-q5eijunp 23 12 , , , cord-262248-q5eijunp 23 13 but but CC cord-262248-q5eijunp 23 14 such such JJ cord-262248-q5eijunp 23 15 preparations preparation NNS cord-262248-q5eijunp 23 16 were be VBD cord-262248-q5eijunp 23 17 in in IN cord-262248-q5eijunp 23 18 short short JJ cord-262248-q5eijunp 23 19 supply supply NN cord-262248-q5eijunp 23 20 , , , cord-262248-q5eijunp 23 21 and and CC cord-262248-q5eijunp 23 22 , , , cord-262248-q5eijunp 23 23 in in IN cord-262248-q5eijunp 23 24 retrospect retrospect NN cord-262248-q5eijunp 23 25 , , , cord-262248-q5eijunp 23 26 carried carry VBD cord-262248-q5eijunp 23 27 the the DT cord-262248-q5eijunp 23 28 risk risk NN cord-262248-q5eijunp 23 29 of of IN cord-262248-q5eijunp 23 30 inadvertent inadvertent JJ cord-262248-q5eijunp 23 31 transmission transmission NN cord-262248-q5eijunp 23 32 of of IN cord-262248-q5eijunp 23 33 blood blood NN cord-262248-q5eijunp 23 34 borne bear VBN cord-262248-q5eijunp 23 35 diseases disease NNS cord-262248-q5eijunp 23 36 . . . cord-262248-q5eijunp 24 1 Nevertheless nevertheless RB cord-262248-q5eijunp 24 2 , , , cord-262248-q5eijunp 24 3 in in IN cord-262248-q5eijunp 24 4 the the DT cord-262248-q5eijunp 24 5 latter latter JJ cord-262248-q5eijunp 24 6 half half NN cord-262248-q5eijunp 24 7 of of IN cord-262248-q5eijunp 24 8 the the DT cord-262248-q5eijunp 24 9 20 20 CD cord-262248-q5eijunp 24 10 th th XX cord-262248-q5eijunp 24 11 century century NN cord-262248-q5eijunp 24 12 , , , cord-262248-q5eijunp 24 13 immune immune JJ cord-262248-q5eijunp 24 14 gamma gamma NN cord-262248-q5eijunp 24 15 globulin globulin NN cord-262248-q5eijunp 24 16 preparations preparation NNS cord-262248-q5eijunp 24 17 were be VBD cord-262248-q5eijunp 24 18 recommended recommend VBN cord-262248-q5eijunp 24 19 in in IN cord-262248-q5eijunp 24 20 certain certain JJ cord-262248-q5eijunp 24 21 clinical clinical JJ cord-262248-q5eijunp 24 22 settings setting NNS cord-262248-q5eijunp 24 23 for for IN cord-262248-q5eijunp 24 24 the the DT cord-262248-q5eijunp 24 25 prevention prevention NN cord-262248-q5eijunp 24 26 and and CC cord-262248-q5eijunp 24 27 therapy therapy NN cord-262248-q5eijunp 24 28 of of IN cord-262248-q5eijunp 24 29 diseases disease NNS cord-262248-q5eijunp 24 30 caused cause VBN cord-262248-q5eijunp 24 31 by by IN cord-262248-q5eijunp 24 32 Hepatis Hepatis NNP cord-262248-q5eijunp 24 33 B B NNP cord-262248-q5eijunp 24 34 virus virus NN cord-262248-q5eijunp 24 35 , , , cord-262248-q5eijunp 24 36 cytomegalovirus cytomegalovirus NNP cord-262248-q5eijunp 24 37 , , , cord-262248-q5eijunp 24 38 rabies rabies NN cord-262248-q5eijunp 24 39 virus virus NN cord-262248-q5eijunp 24 40 , , , cord-262248-q5eijunp 24 41 tetanus tetanus NN cord-262248-q5eijunp 24 42 toxin toxin NN cord-262248-q5eijunp 24 43 , , , cord-262248-q5eijunp 24 44 and and CC cord-262248-q5eijunp 24 45 botulinum botulinum NN cord-262248-q5eijunp 24 46 toxin toxin NN cord-262248-q5eijunp 24 47 , , , cord-262248-q5eijunp 24 48 among among IN cord-262248-q5eijunp 24 49 others other NNS cord-262248-q5eijunp 24 50 . . . cord-262248-q5eijunp 25 1 Since since IN cord-262248-q5eijunp 25 2 the the DT cord-262248-q5eijunp 25 3 mid-1970s mid-1970 NNS cord-262248-q5eijunp 25 4 , , , cord-262248-q5eijunp 25 5 monoclonal monoclonal JJ cord-262248-q5eijunp 25 6 antibodies antibody NNS cord-262248-q5eijunp 25 7 have have VBP cord-262248-q5eijunp 25 8 been be VBN cord-262248-q5eijunp 25 9 available available JJ cord-262248-q5eijunp 25 10 and and CC cord-262248-q5eijunp 25 11 tools tool NNS cord-262248-q5eijunp 25 12 now now RB cord-262248-q5eijunp 25 13 exist exist VBP cord-262248-q5eijunp 25 14 for for IN cord-262248-q5eijunp 25 15 reducing reduce VBG cord-262248-q5eijunp 25 16 the the DT cord-262248-q5eijunp 25 17 antigenicity antigenicity NN cord-262248-q5eijunp 25 18 of of IN cord-262248-q5eijunp 25 19 animal animal NN cord-262248-q5eijunp 25 20 antibodies antibody NNS cord-262248-q5eijunp 25 21 through through IN cord-262248-q5eijunp 25 22 humanization humanization NN cord-262248-q5eijunp 25 23 and and CC cord-262248-q5eijunp 25 24 for for IN cord-262248-q5eijunp 25 25 the the DT cord-262248-q5eijunp 25 26 generation generation NN cord-262248-q5eijunp 25 27 of of IN cord-262248-q5eijunp 25 28 fully fully RB cord-262248-q5eijunp 25 29 human human JJ cord-262248-q5eijunp 25 30 Abs abs NN cord-262248-q5eijunp 25 31 . . . cord-262248-q5eijunp 26 1 Given give VBN cord-262248-q5eijunp 26 2 that that IN cord-262248-q5eijunp 26 3 Abs abs NN cord-262248-q5eijunp 26 4 are be VBP cord-262248-q5eijunp 26 5 natural natural JJ cord-262248-q5eijunp 26 6 products product NNS cord-262248-q5eijunp 26 7 , , , cord-262248-q5eijunp 26 8 they -PRON- PRP cord-262248-q5eijunp 26 9 have have VBP cord-262248-q5eijunp 26 10 little little JJ cord-262248-q5eijunp 26 11 inherent inherent JJ cord-262248-q5eijunp 26 12 toxicity toxicity NN cord-262248-q5eijunp 26 13 and and CC cord-262248-q5eijunp 26 14 the the DT cord-262248-q5eijunp 26 15 ability ability NN cord-262248-q5eijunp 26 16 to to TO cord-262248-q5eijunp 26 17 reduce reduce VB cord-262248-q5eijunp 26 18 or or CC cord-262248-q5eijunp 26 19 eliminate eliminate VB cord-262248-q5eijunp 26 20 their -PRON- PRP$ cord-262248-q5eijunp 26 21 antigenicity antigenicity NN cord-262248-q5eijunp 26 22 means mean VBZ cord-262248-q5eijunp 26 23 that that IN cord-262248-q5eijunp 26 24 side side NN cord-262248-q5eijunp 26 25 effects effect NNS cord-262248-q5eijunp 26 26 associated associate VBN cord-262248-q5eijunp 26 27 with with IN cord-262248-q5eijunp 26 28 serum serum NN cord-262248-q5eijunp 26 29 therapy therapy NN cord-262248-q5eijunp 26 30 are be VBP cord-262248-q5eijunp 26 31 significantly significantly RB cord-262248-q5eijunp 26 32 diminished diminish VBN cord-262248-q5eijunp 26 33 . . . cord-262248-q5eijunp 27 1 Perhaps perhaps RB cord-262248-q5eijunp 27 2 the the DT cord-262248-q5eijunp 27 3 greatest great JJS cord-262248-q5eijunp 27 4 difference difference NN cord-262248-q5eijunp 27 5 between between IN cord-262248-q5eijunp 27 6 Ab ab NN cord-262248-q5eijunp 27 7 and and CC cord-262248-q5eijunp 27 8 conventional conventional JJ cord-262248-q5eijunp 27 9 antimicrobial antimicrobial JJ cord-262248-q5eijunp 27 10 therapies therapy NNS cord-262248-q5eijunp 27 11 is be VBZ cord-262248-q5eijunp 27 12 the the DT cord-262248-q5eijunp 27 13 exquisite exquisite JJ cord-262248-q5eijunp 27 14 specificity specificity NN cord-262248-q5eijunp 27 15 of of IN cord-262248-q5eijunp 27 16 most most JJS cord-262248-q5eijunp 27 17 immunoglobulin immunoglobulin NN cord-262248-q5eijunp 27 18 molecules molecule NNS cord-262248-q5eijunp 27 19 for for IN cord-262248-q5eijunp 27 20 their -PRON- PRP$ cord-262248-q5eijunp 27 21 targets target NNS cord-262248-q5eijunp 27 22 . . . cord-262248-q5eijunp 28 1 Unlike unlike IN cord-262248-q5eijunp 28 2 most most JJS cord-262248-q5eijunp 28 3 antimicrobial antimicrobial JJ cord-262248-q5eijunp 28 4 drugs drug NNS cord-262248-q5eijunp 28 5 that that WDT cord-262248-q5eijunp 28 6 function function VBP cord-262248-q5eijunp 28 7 indiscriminately indiscriminately RB cord-262248-q5eijunp 28 8 against against IN cord-262248-q5eijunp 28 9 multiple multiple JJ cord-262248-q5eijunp 28 10 species specie NNS cord-262248-q5eijunp 28 11 , , , cord-262248-q5eijunp 28 12 antibodies antibody NNS cord-262248-q5eijunp 28 13 target target VBP cord-262248-q5eijunp 28 14 a a DT cord-262248-q5eijunp 28 15 single single JJ cord-262248-q5eijunp 28 16 species specie NNS cord-262248-q5eijunp 28 17 and and CC cord-262248-q5eijunp 28 18 , , , cord-262248-q5eijunp 28 19 often often RB cord-262248-q5eijunp 28 20 , , , cord-262248-q5eijunp 28 21 a a DT cord-262248-q5eijunp 28 22 single single JJ cord-262248-q5eijunp 28 23 serotype serotype NN cord-262248-q5eijunp 28 24 or or CC cord-262248-q5eijunp 28 25 variant variant NN cord-262248-q5eijunp 28 26 within within IN cord-262248-q5eijunp 28 27 a a DT cord-262248-q5eijunp 28 28 species species NN cord-262248-q5eijunp 28 29 . . . cord-262248-q5eijunp 29 1 This this DT cord-262248-q5eijunp 29 2 is be VBZ cord-262248-q5eijunp 29 3 a a DT cord-262248-q5eijunp 29 4 double double RB cord-262248-q5eijunp 29 5 - - HYPH cord-262248-q5eijunp 29 6 edged edged JJ cord-262248-q5eijunp 29 7 sword sword NN cord-262248-q5eijunp 29 8 for for IN cord-262248-q5eijunp 29 9 the the DT cord-262248-q5eijunp 29 10 development development NN cord-262248-q5eijunp 29 11 of of IN cord-262248-q5eijunp 29 12 Ab Ab NNP cord-262248-q5eijunp 29 13 therapies therapy NNS cord-262248-q5eijunp 29 14 . . . cord-262248-q5eijunp 30 1 Great great JJ cord-262248-q5eijunp 30 2 specificity specificity NN cord-262248-q5eijunp 30 3 has have VBZ cord-262248-q5eijunp 30 4 the the DT cord-262248-q5eijunp 30 5 advantage advantage NN cord-262248-q5eijunp 30 6 that that WDT cord-262248-q5eijunp 30 7 it -PRON- PRP cord-262248-q5eijunp 30 8 targets target VBZ cord-262248-q5eijunp 30 9 only only RB cord-262248-q5eijunp 30 10 the the DT cord-262248-q5eijunp 30 11 offending offend VBG cord-262248-q5eijunp 30 12 microbe microbe NN cord-262248-q5eijunp 30 13 . . . cord-262248-q5eijunp 31 1 For for IN cord-262248-q5eijunp 31 2 example example NN cord-262248-q5eijunp 31 3 , , , cord-262248-q5eijunp 31 4 given give VBN cord-262248-q5eijunp 31 5 that that IN cord-262248-q5eijunp 31 6 there there EX cord-262248-q5eijunp 31 7 is be VBZ cord-262248-q5eijunp 31 8 increasing increase VBG cord-262248-q5eijunp 31 9 evidence evidence NN cord-262248-q5eijunp 31 10 that that IN cord-262248-q5eijunp 31 11 antibiotic antibiotic NN cord-262248-q5eijunp 31 12 - - HYPH cord-262248-q5eijunp 31 13 induced induce VBN cord-262248-q5eijunp 31 14 disruptions disruption NNS cord-262248-q5eijunp 31 15 of of IN cord-262248-q5eijunp 31 16 the the DT cord-262248-q5eijunp 31 17 microbiota microbiota NN cord-262248-q5eijunp 31 18 are be VBP cord-262248-q5eijunp 31 19 associated associate VBN cord-262248-q5eijunp 31 20 with with IN cord-262248-q5eijunp 31 21 deleterious deleterious JJ cord-262248-q5eijunp 31 22 effects effect NNS cord-262248-q5eijunp 31 23 in in IN cord-262248-q5eijunp 31 24 the the DT cord-262248-q5eijunp 31 25 treatment treatment NN cord-262248-q5eijunp 31 26 of of IN cord-262248-q5eijunp 31 27 bacterial bacterial JJ cord-262248-q5eijunp 31 28 diseases disease NNS cord-262248-q5eijunp 31 29 , , , cord-262248-q5eijunp 31 30 the the DT cord-262248-q5eijunp 31 31 high high JJ cord-262248-q5eijunp 31 32 specificity specificity NN cord-262248-q5eijunp 31 33 of of IN cord-262248-q5eijunp 31 34 Ab ab NN cord-262248-q5eijunp 31 35 - - HYPH cord-262248-q5eijunp 31 36 based base VBN cord-262248-q5eijunp 31 37 therapies therapy NNS cord-262248-q5eijunp 31 38 offers offer VBZ cord-262248-q5eijunp 31 39 a a DT cord-262248-q5eijunp 31 40 tremendous tremendous JJ cord-262248-q5eijunp 31 41 advantage advantage NN cord-262248-q5eijunp 31 42 . . . cord-262248-q5eijunp 32 1 Regarding regard VBG cord-262248-q5eijunp 32 2 the the DT cord-262248-q5eijunp 32 3 limitation limitation NN cord-262248-q5eijunp 32 4 that that WDT cord-262248-q5eijunp 32 5 highly highly RB cord-262248-q5eijunp 32 6 specific specific JJ cord-262248-q5eijunp 32 7 Abs abs NN cord-262248-q5eijunp 32 8 can can MD cord-262248-q5eijunp 32 9 fail fail VB cord-262248-q5eijunp 32 10 to to TO cord-262248-q5eijunp 32 11 bind bind VB cord-262248-q5eijunp 32 12 highly highly RB cord-262248-q5eijunp 32 13 related relate VBN cord-262248-q5eijunp 32 14 variants variant NNS cord-262248-q5eijunp 32 15 , , , cord-262248-q5eijunp 32 16 particularly particularly RB cord-262248-q5eijunp 32 17 for for IN cord-262248-q5eijunp 32 18 viruses virus NNS cord-262248-q5eijunp 32 19 , , , cord-262248-q5eijunp 32 20 there there EX cord-262248-q5eijunp 32 21 are be VBP cord-262248-q5eijunp 32 22 two two CD cord-262248-q5eijunp 32 23 strategies strategy NNS cord-262248-q5eijunp 32 24 to to TO cord-262248-q5eijunp 32 25 overcome overcome VB cord-262248-q5eijunp 32 26 this this DT cord-262248-q5eijunp 32 27 problem problem NN cord-262248-q5eijunp 32 28 : : : cord-262248-q5eijunp 32 29 the the DT cord-262248-q5eijunp 32 30 development development NN cord-262248-q5eijunp 32 31 of of IN cord-262248-q5eijunp 32 32 Abs Abs NNP cord-262248-q5eijunp 32 33 that that WDT cord-262248-q5eijunp 32 34 target target VBP cord-262248-q5eijunp 32 35 broadly broadly RB cord-262248-q5eijunp 32 36 neutralizing neutralize VBG cord-262248-q5eijunp 32 37 epitopes epitope NNS cord-262248-q5eijunp 32 38 , , , cord-262248-q5eijunp 32 39 as as IN cord-262248-q5eijunp 32 40 has have VBZ cord-262248-q5eijunp 32 41 now now RB cord-262248-q5eijunp 32 42 been be VBN cord-262248-q5eijunp 32 43 demonstrated demonstrate VBN cord-262248-q5eijunp 32 44 for for IN cord-262248-q5eijunp 32 45 HIV HIV NNP cord-262248-q5eijunp 32 46 [ [ -LRB- cord-262248-q5eijunp 32 47 8 8 CD cord-262248-q5eijunp 32 48 ] ] -RRB- cord-262248-q5eijunp 32 49 , , , cord-262248-q5eijunp 32 50 dengue dengue NN cord-262248-q5eijunp 32 51 [ [ -LRB- cord-262248-q5eijunp 32 52 9 9 CD cord-262248-q5eijunp 32 53 ] ] -RRB- cord-262248-q5eijunp 32 54 , , , cord-262248-q5eijunp 32 55 and and CC cord-262248-q5eijunp 32 56 influenza influenza NN cord-262248-q5eijunp 32 57 viruses virus NNS cord-262248-q5eijunp 32 58 [ [ -LRB- cord-262248-q5eijunp 32 59 10 10 CD cord-262248-q5eijunp 32 60 ] ] -RRB- cord-262248-q5eijunp 32 61 , , , cord-262248-q5eijunp 32 62 and and CC cord-262248-q5eijunp 32 63 the the DT cord-262248-q5eijunp 32 64 generation generation NN cord-262248-q5eijunp 32 65 of of IN cord-262248-q5eijunp 32 66 Ab Ab NNP cord-262248-q5eijunp 32 67 cocktails cocktail NNS cord-262248-q5eijunp 32 68 composed compose VBN cord-262248-q5eijunp 32 69 of of IN cord-262248-q5eijunp 32 70 Abs Abs NNP cord-262248-q5eijunp 32 71 against against IN cord-262248-q5eijunp 32 72 multiple multiple JJ cord-262248-q5eijunp 32 73 serotypes serotype NNS cord-262248-q5eijunp 32 74 or or CC cord-262248-q5eijunp 32 75 variants variant NNS cord-262248-q5eijunp 32 76 , , , cord-262248-q5eijunp 32 77 as as IN cord-262248-q5eijunp 32 78 has have VBZ cord-262248-q5eijunp 32 79 been be VBN cord-262248-q5eijunp 32 80 done do VBN cord-262248-q5eijunp 32 81 for for IN cord-262248-q5eijunp 32 82 rabies rabies NN cord-262248-q5eijunp 32 83 virus virus NN cord-262248-q5eijunp 32 84 [ [ -LRB- cord-262248-q5eijunp 32 85 11 11 CD cord-262248-q5eijunp 32 86 ] ] -RRB- cord-262248-q5eijunp 32 87 and and CC cord-262248-q5eijunp 32 88 Clostridium clostridium NN cord-262248-q5eijunp 32 89 difficile difficile NN cord-262248-q5eijunp 32 90 toxin toxin NN cord-262248-q5eijunp 32 91 [ [ -LRB- cord-262248-q5eijunp 32 92 12 12 CD cord-262248-q5eijunp 32 93 ] ] -RRB- cord-262248-q5eijunp 32 94 . . . cord-262248-q5eijunp 33 1 Similarly similarly RB cord-262248-q5eijunp 33 2 , , , cord-262248-q5eijunp 33 3 although although IN cord-262248-q5eijunp 33 4 sera sera NNP cord-262248-q5eijunp 33 5 from from IN cord-262248-q5eijunp 33 6 patients patient NNS cord-262248-q5eijunp 33 7 who who WP cord-262248-q5eijunp 33 8 have have VBP cord-262248-q5eijunp 33 9 recovered recover VBN cord-262248-q5eijunp 33 10 from from IN cord-262248-q5eijunp 33 11 Ebola Ebola NNP cord-262248-q5eijunp 33 12 virus virus NN cord-262248-q5eijunp 33 13 disease disease NN cord-262248-q5eijunp 33 14 can can MD cord-262248-q5eijunp 33 15 exhibit exhibit VB cord-262248-q5eijunp 33 16 persistent persistent JJ cord-262248-q5eijunp 33 17 neutralizing neutralize VBG cord-262248-q5eijunp 33 18 activity activity NN cord-262248-q5eijunp 33 19 [ [ -LRB- cord-262248-q5eijunp 33 20 13 13 CD cord-262248-q5eijunp 33 21 ] ] -RRB- cord-262248-q5eijunp 33 22 , , , cord-262248-q5eijunp 33 23 antibodies antibody NNS cord-262248-q5eijunp 33 24 against against IN cord-262248-q5eijunp 33 25 different different JJ cord-262248-q5eijunp 33 26 Ebola Ebola NNP cord-262248-q5eijunp 33 27 virus virus NN cord-262248-q5eijunp 33 28 strains strain NNS cord-262248-q5eijunp 33 29 often often RB cord-262248-q5eijunp 33 30 do do VBP cord-262248-q5eijunp 33 31 not not RB cord-262248-q5eijunp 33 32 cross cross VB cord-262248-q5eijunp 33 33 - - JJ cord-262248-q5eijunp 33 34 react react VB cord-262248-q5eijunp 33 35 with with IN cord-262248-q5eijunp 33 36 other other JJ cord-262248-q5eijunp 33 37 strains strain NNS cord-262248-q5eijunp 33 38 [ [ -LRB- cord-262248-q5eijunp 33 39 14 14 CD cord-262248-q5eijunp 33 40 ] ] -RRB- cord-262248-q5eijunp 33 41 . . . cord-262248-q5eijunp 34 1 In in IN cord-262248-q5eijunp 34 2 the the DT cord-262248-q5eijunp 34 3 pre pre JJ cord-262248-q5eijunp 34 4 - - JJ cord-262248-q5eijunp 34 5 antibiotic antibiotic JJ cord-262248-q5eijunp 34 6 era era NN cord-262248-q5eijunp 34 7 , , , cord-262248-q5eijunp 34 8 this this DT cord-262248-q5eijunp 34 9 was be VBD cord-262248-q5eijunp 34 10 addressed address VBN cord-262248-q5eijunp 34 11 by by IN cord-262248-q5eijunp 34 12 using use VBG cord-262248-q5eijunp 34 13 serotype serotype NN cord-262248-q5eijunp 34 14 - - HYPH cord-262248-q5eijunp 34 15 specific specific JJ cord-262248-q5eijunp 34 16 sera sera FW cord-262248-q5eijunp 34 17 that that WDT cord-262248-q5eijunp 34 18 required require VBD cord-262248-q5eijunp 34 19 isolating isolate VBG cord-262248-q5eijunp 34 20 and and CC cord-262248-q5eijunp 34 21 typing type VBG cord-262248-q5eijunp 34 22 the the DT cord-262248-q5eijunp 34 23 strain strain NN cord-262248-q5eijunp 34 24 before before IN cord-262248-q5eijunp 34 25 instituting institute VBG cord-262248-q5eijunp 34 26 therapy therapy NN cord-262248-q5eijunp 34 27 . . . cord-262248-q5eijunp 35 1 The the DT cord-262248-q5eijunp 35 2 problem problem NN cord-262248-q5eijunp 35 3 is be VBZ cord-262248-q5eijunp 35 4 especially especially RB cord-262248-q5eijunp 35 5 acute acute JJ cord-262248-q5eijunp 35 6 for for IN cord-262248-q5eijunp 35 7 mAbs mAbs NNP cord-262248-q5eijunp 35 8 , , , cord-262248-q5eijunp 35 9 which which WDT cord-262248-q5eijunp 35 10 recognize recognize VBP cord-262248-q5eijunp 35 11 a a DT cord-262248-q5eijunp 35 12 single single JJ cord-262248-q5eijunp 35 13 epitope epitope NN cord-262248-q5eijunp 35 14 , , , cord-262248-q5eijunp 35 15 but but CC cord-262248-q5eijunp 35 16 this this DT cord-262248-q5eijunp 35 17 limitation limitation NN cord-262248-q5eijunp 35 18 can can MD cord-262248-q5eijunp 35 19 be be VB cord-262248-q5eijunp 35 20 bypassed bypass VBN cord-262248-q5eijunp 35 21 by by IN cord-262248-q5eijunp 35 22 creating create VBG cord-262248-q5eijunp 35 23 cocktails cocktail NNS cord-262248-q5eijunp 35 24 targeting target VBG cord-262248-q5eijunp 35 25 various various JJ cord-262248-q5eijunp 35 26 subtypes subtype NNS cord-262248-q5eijunp 35 27 , , , cord-262248-q5eijunp 35 28 although although IN cord-262248-q5eijunp 35 29 this this DT cord-262248-q5eijunp 35 30 increases increase VBZ cord-262248-q5eijunp 35 31 the the DT cord-262248-q5eijunp 35 32 cost cost NN cord-262248-q5eijunp 35 33 of of IN cord-262248-q5eijunp 35 34 research research NN cord-262248-q5eijunp 35 35 and and CC cord-262248-q5eijunp 35 36 development development NN cord-262248-q5eijunp 35 37 . . . cord-262248-q5eijunp 36 1 MAb MAb NNS cord-262248-q5eijunp 36 2 cocktails cocktail NNS cord-262248-q5eijunp 36 3 can can MD cord-262248-q5eijunp 36 4 also also RB cord-262248-q5eijunp 36 5 be be VB cord-262248-q5eijunp 36 6 designed design VBN cord-262248-q5eijunp 36 7 to to TO cord-262248-q5eijunp 36 8 neutralize neutralize VB cord-262248-q5eijunp 36 9 different different JJ cord-262248-q5eijunp 36 10 targets target NNS cord-262248-q5eijunp 36 11 with with IN cord-262248-q5eijunp 36 12 the the DT cord-262248-q5eijunp 36 13 goal goal NN cord-262248-q5eijunp 36 14 of of IN cord-262248-q5eijunp 36 15 achieving achieve VBG cord-262248-q5eijunp 36 16 higher high JJR cord-262248-q5eijunp 36 17 efficacy efficacy NN cord-262248-q5eijunp 36 18 through through IN cord-262248-q5eijunp 36 19 synergy synergy NN cord-262248-q5eijunp 36 20 . . . cord-262248-q5eijunp 37 1 It -PRON- PRP cord-262248-q5eijunp 37 2 is be VBZ cord-262248-q5eijunp 37 3 noteworthy noteworthy JJ cord-262248-q5eijunp 37 4 that that IN cord-262248-q5eijunp 37 5 the the DT cord-262248-q5eijunp 37 6 experimental experimental JJ cord-262248-q5eijunp 37 7 mAb mab NN cord-262248-q5eijunp 37 8 treatment treatment NN cord-262248-q5eijunp 37 9 of of IN cord-262248-q5eijunp 37 10 Ebola Ebola NNP cord-262248-q5eijunp 37 11 , , , cord-262248-q5eijunp 37 12 Zmapp Zmapp NNP cord-262248-q5eijunp 37 13 , , , cord-262248-q5eijunp 37 14 consists consist VBZ cord-262248-q5eijunp 37 15 of of IN cord-262248-q5eijunp 37 16 a a DT cord-262248-q5eijunp 37 17 cocktail cocktail NN cord-262248-q5eijunp 37 18 of of IN cord-262248-q5eijunp 37 19 three three CD cord-262248-q5eijunp 37 20 mouse mouse NN cord-262248-q5eijunp 37 21 - - HYPH cord-262248-q5eijunp 37 22 human human JJ cord-262248-q5eijunp 37 23 chimeric chimeric JJ cord-262248-q5eijunp 37 24 Abs Abs NNP cord-262248-q5eijunp 37 25 directed direct VBN cord-262248-q5eijunp 37 26 to to IN cord-262248-q5eijunp 37 27 the the DT cord-262248-q5eijunp 37 28 viral viral JJ cord-262248-q5eijunp 37 29 glycoprotein glycoprotein NN cord-262248-q5eijunp 37 30 [ [ -LRB- cord-262248-q5eijunp 37 31 3 3 CD cord-262248-q5eijunp 37 32 ] ] -RRB- cord-262248-q5eijunp 37 33 . . . cord-262248-q5eijunp 38 1 For for IN cord-262248-q5eijunp 38 2 reasons reason NNS cord-262248-q5eijunp 38 3 that that WDT cord-262248-q5eijunp 38 4 are be VBP cord-262248-q5eijunp 38 5 not not RB cord-262248-q5eijunp 38 6 fully fully RB cord-262248-q5eijunp 38 7 understood understand VBN cord-262248-q5eijunp 38 8 , , , cord-262248-q5eijunp 38 9 Ab Ab NNP cord-262248-q5eijunp 38 10 therapies therapy NNS cord-262248-q5eijunp 38 11 work work VBP cord-262248-q5eijunp 38 12 best best RB cord-262248-q5eijunp 38 13 when when WRB cord-262248-q5eijunp 38 14 given give VBN cord-262248-q5eijunp 38 15 in in IN cord-262248-q5eijunp 38 16 a a DT cord-262248-q5eijunp 38 17 prophylactic prophylactic JJ cord-262248-q5eijunp 38 18 mode mode NN cord-262248-q5eijunp 38 19 ( ( -LRB- cord-262248-q5eijunp 38 20 e.g. e.g. RB cord-262248-q5eijunp 38 21 , , , cord-262248-q5eijunp 38 22 before before IN cord-262248-q5eijunp 38 23 infection infection NN cord-262248-q5eijunp 38 24 ) ) -RRB- cord-262248-q5eijunp 38 25 or or CC cord-262248-q5eijunp 38 26 early early RB cord-262248-q5eijunp 38 27 in in IN cord-262248-q5eijunp 38 28 the the DT cord-262248-q5eijunp 38 29 course course NN cord-262248-q5eijunp 38 30 of of IN cord-262248-q5eijunp 38 31 disease disease NN cord-262248-q5eijunp 38 32 . . . cord-262248-q5eijunp 39 1 For for IN cord-262248-q5eijunp 39 2 example example NN cord-262248-q5eijunp 39 3 , , , cord-262248-q5eijunp 39 4 serum serum NN cord-262248-q5eijunp 39 5 therapy therapy NN cord-262248-q5eijunp 39 6 for for IN cord-262248-q5eijunp 39 7 the the DT cord-262248-q5eijunp 39 8 treatment treatment NN cord-262248-q5eijunp 39 9 of of IN cord-262248-q5eijunp 39 10 pneumococcal pneumococcal JJ cord-262248-q5eijunp 39 11 pneumonia pneumonia NN cord-262248-q5eijunp 39 12 was be VBD cord-262248-q5eijunp 39 13 effective effective JJ cord-262248-q5eijunp 39 14 only only RB cord-262248-q5eijunp 39 15 when when WRB cord-262248-q5eijunp 39 16 given give VBN cord-262248-q5eijunp 39 17 within within IN cord-262248-q5eijunp 39 18 the the DT cord-262248-q5eijunp 39 19 first first JJ cord-262248-q5eijunp 39 20 three three CD cord-262248-q5eijunp 39 21 days day NNS cord-262248-q5eijunp 39 22 of of IN cord-262248-q5eijunp 39 23 symptoms symptom NNS cord-262248-q5eijunp 39 24 . . . cord-262248-q5eijunp 40 1 In in IN cord-262248-q5eijunp 40 2 contrast contrast NN cord-262248-q5eijunp 40 3 , , , cord-262248-q5eijunp 40 4 antimicrobial antimicrobial JJ cord-262248-q5eijunp 40 5 agents agent NNS cord-262248-q5eijunp 40 6 are be VBP cord-262248-q5eijunp 40 7 often often RB cord-262248-q5eijunp 40 8 effective effective JJ cord-262248-q5eijunp 40 9 in in IN cord-262248-q5eijunp 40 10 established establish VBN cord-262248-q5eijunp 40 11 infection infection NN cord-262248-q5eijunp 40 12 and and CC cord-262248-q5eijunp 40 13 disease disease NN cord-262248-q5eijunp 40 14 . . . cord-262248-q5eijunp 41 1 One one CD cord-262248-q5eijunp 41 2 proposed propose VBN cord-262248-q5eijunp 41 3 explanation explanation NN cord-262248-q5eijunp 41 4 for for IN cord-262248-q5eijunp 41 5 this this DT cord-262248-q5eijunp 41 6 limitation limitation NN cord-262248-q5eijunp 41 7 is be VBZ cord-262248-q5eijunp 41 8 that that IN cord-262248-q5eijunp 41 9 Abs abs NN cord-262248-q5eijunp 41 10 work work NN cord-262248-q5eijunp 41 11 best best RB cord-262248-q5eijunp 41 12 in in IN cord-262248-q5eijunp 41 13 neutralizing neutralize VBG cord-262248-q5eijunp 41 14 the the DT cord-262248-q5eijunp 41 15 infective infective JJ cord-262248-q5eijunp 41 16 inoculum inoculum NN cord-262248-q5eijunp 41 17 and and CC cord-262248-q5eijunp 41 18 can can MD cord-262248-q5eijunp 41 19 not not RB cord-262248-q5eijunp 41 20 cope cope VB cord-262248-q5eijunp 41 21 with with IN cord-262248-q5eijunp 41 22 the the DT cord-262248-q5eijunp 41 23 high high JJ cord-262248-q5eijunp 41 24 microbial microbial JJ cord-262248-q5eijunp 41 25 burdens burden NNS cord-262248-q5eijunp 41 26 of of IN cord-262248-q5eijunp 41 27 established establish VBN cord-262248-q5eijunp 41 28 infection infection NN cord-262248-q5eijunp 41 29 [ [ -LRB- cord-262248-q5eijunp 41 30 15 15 CD cord-262248-q5eijunp 41 31 ] ] -RRB- cord-262248-q5eijunp 41 32 . . . cord-262248-q5eijunp 42 1 An an DT cord-262248-q5eijunp 42 2 alternative alternative JJ cord-262248-q5eijunp 42 3 explanation explanation NN cord-262248-q5eijunp 42 4 is be VBZ cord-262248-q5eijunp 42 5 that that IN cord-262248-q5eijunp 42 6 Abs abs NN cord-262248-q5eijunp 42 7 work work NN cord-262248-q5eijunp 42 8 by by IN cord-262248-q5eijunp 42 9 altering alter VBG cord-262248-q5eijunp 42 10 the the DT cord-262248-q5eijunp 42 11 inflammatory inflammatory JJ cord-262248-q5eijunp 42 12 response response NN cord-262248-q5eijunp 42 13 and and CC cord-262248-q5eijunp 42 14 once once IN cord-262248-q5eijunp 42 15 inflammation inflammation NN cord-262248-q5eijunp 42 16 is be VBZ cord-262248-q5eijunp 42 17 established establish VBN cord-262248-q5eijunp 42 18 that that IN cord-262248-q5eijunp 42 19 it -PRON- PRP cord-262248-q5eijunp 42 20 is be VBZ cord-262248-q5eijunp 42 21 difficult difficult JJ cord-262248-q5eijunp 42 22 for for IN cord-262248-q5eijunp 42 23 Abs abs NN cord-262248-q5eijunp 42 24 to to TO cord-262248-q5eijunp 42 25 exert exert VB cord-262248-q5eijunp 42 26 their -PRON- PRP$ cord-262248-q5eijunp 42 27 protective protective JJ cord-262248-q5eijunp 42 28 functions function NNS cord-262248-q5eijunp 42 29 [ [ -LRB- cord-262248-q5eijunp 42 30 16 16 CD cord-262248-q5eijunp 42 31 ] ] -RRB- cord-262248-q5eijunp 42 32 . . . cord-262248-q5eijunp 43 1 For for IN cord-262248-q5eijunp 43 2 viral viral JJ cord-262248-q5eijunp 43 3 diseases disease NNS cord-262248-q5eijunp 43 4 , , , cord-262248-q5eijunp 43 5 the the DT cord-262248-q5eijunp 43 6 reduced reduce VBN cord-262248-q5eijunp 43 7 efficacy efficacy NN cord-262248-q5eijunp 43 8 of of IN cord-262248-q5eijunp 43 9 Abs abs NN cord-262248-q5eijunp 43 10 in in IN cord-262248-q5eijunp 43 11 treatment treatment NN cord-262248-q5eijunp 43 12 mode mode NN cord-262248-q5eijunp 43 13 could could MD cord-262248-q5eijunp 43 14 reflect reflect VB cord-262248-q5eijunp 43 15 a a DT cord-262248-q5eijunp 43 16 molar molar JJ cord-262248-q5eijunp 43 17 imbalance imbalance NN cord-262248-q5eijunp 43 18 between between IN cord-262248-q5eijunp 43 19 Ab Ab NNP cord-262248-q5eijunp 43 20 molecules molecule NNS cord-262248-q5eijunp 43 21 and and CC cord-262248-q5eijunp 43 22 increasing increase VBG cord-262248-q5eijunp 43 23 numbers number NNS cord-262248-q5eijunp 43 24 of of IN cord-262248-q5eijunp 43 25 viral viral JJ cord-262248-q5eijunp 43 26 particles particle NNS cord-262248-q5eijunp 43 27 , , , cord-262248-q5eijunp 43 28 as as RB cord-262248-q5eijunp 43 29 well well RB cord-262248-q5eijunp 43 30 as as IN cord-262248-q5eijunp 43 31 the the DT cord-262248-q5eijunp 43 32 requirement requirement NN cord-262248-q5eijunp 43 33 for for IN cord-262248-q5eijunp 43 34 cell cell NN cord-262248-q5eijunp 43 35 - - HYPH cord-262248-q5eijunp 43 36 mediated mediate VBN cord-262248-q5eijunp 43 37 immunity immunity NN cord-262248-q5eijunp 43 38 to to TO cord-262248-q5eijunp 43 39 eradicate eradicate VB cord-262248-q5eijunp 43 40 established establish VBN cord-262248-q5eijunp 43 41 infection infection NN cord-262248-q5eijunp 43 42 . . . cord-262248-q5eijunp 44 1 Whatever whatever WDT cord-262248-q5eijunp 44 2 the the DT cord-262248-q5eijunp 44 3 explanation explanation NN cord-262248-q5eijunp 44 4 , , , cord-262248-q5eijunp 44 5 the the DT cord-262248-q5eijunp 44 6 need need NN cord-262248-q5eijunp 44 7 for for IN cord-262248-q5eijunp 44 8 early early JJ cord-262248-q5eijunp 44 9 administration administration NN cord-262248-q5eijunp 44 10 is be VBZ cord-262248-q5eijunp 44 11 a a DT cord-262248-q5eijunp 44 12 limitation limitation NN cord-262248-q5eijunp 44 13 for for IN cord-262248-q5eijunp 44 14 therapy therapy NN cord-262248-q5eijunp 44 15 since since IN cord-262248-q5eijunp 44 16 this this DT cord-262248-q5eijunp 44 17 means mean VBZ cord-262248-q5eijunp 44 18 a a DT cord-262248-q5eijunp 44 19 potential potential JJ cord-262248-q5eijunp 44 20 lack lack NN cord-262248-q5eijunp 44 21 of of IN cord-262248-q5eijunp 44 22 efficacy efficacy NN cord-262248-q5eijunp 44 23 in in IN cord-262248-q5eijunp 44 24 the the DT cord-262248-q5eijunp 44 25 setting setting NN cord-262248-q5eijunp 44 26 of of IN cord-262248-q5eijunp 44 27 advanced advanced JJ cord-262248-q5eijunp 44 28 disease disease NN cord-262248-q5eijunp 44 29 . . . cord-262248-q5eijunp 45 1 However however RB cord-262248-q5eijunp 45 2 , , , cord-262248-q5eijunp 45 3 in in IN cord-262248-q5eijunp 45 4 contrast contrast NN cord-262248-q5eijunp 45 5 to to IN cord-262248-q5eijunp 45 6 antimicrobial antimicrobial JJ cord-262248-q5eijunp 45 7 therapy therapy NN cord-262248-q5eijunp 45 8 , , , cord-262248-q5eijunp 45 9 which which WDT cord-262248-q5eijunp 45 10 mediates mediate VBZ cord-262248-q5eijunp 45 11 protection protection NN cord-262248-q5eijunp 45 12 only only RB cord-262248-q5eijunp 45 13 while while IN cord-262248-q5eijunp 45 14 the the DT cord-262248-q5eijunp 45 15 drug drug NN cord-262248-q5eijunp 45 16 is be VBZ cord-262248-q5eijunp 45 17 pharmacologically pharmacologically RB cord-262248-q5eijunp 45 18 available available JJ cord-262248-q5eijunp 45 19 , , , cord-262248-q5eijunp 45 20 the the DT cord-262248-q5eijunp 45 21 administration administration NN cord-262248-q5eijunp 45 22 of of IN cord-262248-q5eijunp 45 23 Ab Ab NNP cord-262248-q5eijunp 45 24 results result VBZ cord-262248-q5eijunp 45 25 in in IN cord-262248-q5eijunp 45 26 a a DT cord-262248-q5eijunp 45 27 state state NN cord-262248-q5eijunp 45 28 of of IN cord-262248-q5eijunp 45 29 immediate immediate JJ cord-262248-q5eijunp 45 30 immunity immunity NN cord-262248-q5eijunp 45 31 that that WDT cord-262248-q5eijunp 45 32 , , , cord-262248-q5eijunp 45 33 combined combine VBN cord-262248-q5eijunp 45 34 with with IN cord-262248-q5eijunp 45 35 the the DT cord-262248-q5eijunp 45 36 long long JJ cord-262248-q5eijunp 45 37 half half JJ cord-262248-q5eijunp 45 38 - - HYPH cord-262248-q5eijunp 45 39 life life NN cord-262248-q5eijunp 45 40 of of IN cord-262248-q5eijunp 45 41 certain certain JJ cord-262248-q5eijunp 45 42 immunological immunological JJ cord-262248-q5eijunp 45 43 molecules molecule NNS cord-262248-q5eijunp 45 44 , , , cord-262248-q5eijunp 45 45 can can MD cord-262248-q5eijunp 45 46 confer confer VB cord-262248-q5eijunp 45 47 a a DT cord-262248-q5eijunp 45 48 long long RB cord-262248-q5eijunp 45 49 - - HYPH cord-262248-q5eijunp 45 50 standing stand VBG cord-262248-q5eijunp 45 51 state state NN cord-262248-q5eijunp 45 52 of of IN cord-262248-q5eijunp 45 53 reduced reduced JJ cord-262248-q5eijunp 45 54 susceptibility susceptibility NN cord-262248-q5eijunp 45 55 . . . cord-262248-q5eijunp 46 1 In in IN cord-262248-q5eijunp 46 2 contrast contrast NN cord-262248-q5eijunp 46 3 to to IN cord-262248-q5eijunp 46 4 conventional conventional JJ cord-262248-q5eijunp 46 5 antimicrobial antimicrobial JJ cord-262248-q5eijunp 46 6 therapies therapy NNS cord-262248-q5eijunp 46 7 , , , cord-262248-q5eijunp 46 8 Ab Ab NNP cord-262248-q5eijunp 46 9 therapies therapy NNS cord-262248-q5eijunp 46 10 can can MD cord-262248-q5eijunp 46 11 be be VB cord-262248-q5eijunp 46 12 developed develop VBN cord-262248-q5eijunp 46 13 extremely extremely RB cord-262248-q5eijunp 46 14 quickly quickly RB cord-262248-q5eijunp 46 15 and and CC cord-262248-q5eijunp 46 16 , , , cord-262248-q5eijunp 46 17 sometimes sometimes RB cord-262248-q5eijunp 46 18 , , , cord-262248-q5eijunp 46 19 in in IN cord-262248-q5eijunp 46 20 the the DT cord-262248-q5eijunp 46 21 midst midst NN cord-262248-q5eijunp 46 22 of of IN cord-262248-q5eijunp 46 23 an an DT cord-262248-q5eijunp 46 24 epidemic epidemic NN cord-262248-q5eijunp 46 25 . . . cord-262248-q5eijunp 47 1 For for IN cord-262248-q5eijunp 47 2 example example NN cord-262248-q5eijunp 47 3 , , , cord-262248-q5eijunp 47 4 a a DT cord-262248-q5eijunp 47 5 potentially potentially RB cord-262248-q5eijunp 47 6 clinically clinically RB cord-262248-q5eijunp 47 7 useful useful JJ cord-262248-q5eijunp 47 8 mAb mAb NNS cord-262248-q5eijunp 47 9 against against IN cord-262248-q5eijunp 47 10 the the DT cord-262248-q5eijunp 47 11 coronavirus coronavirus NN cord-262248-q5eijunp 47 12 responsible responsible JJ cord-262248-q5eijunp 47 13 for for IN cord-262248-q5eijunp 47 14 the the DT cord-262248-q5eijunp 47 15 severe severe JJ cord-262248-q5eijunp 47 16 acute acute JJ cord-262248-q5eijunp 47 17 respiratory respiratory JJ cord-262248-q5eijunp 47 18 syndrome syndrome NN cord-262248-q5eijunp 47 19 ( ( -LRB- cord-262248-q5eijunp 47 20 SARS SARS NNP cord-262248-q5eijunp 47 21 ) ) -RRB- cord-262248-q5eijunp 47 22 was be VBD cord-262248-q5eijunp 47 23 rapidly rapidly RB cord-262248-q5eijunp 47 24 generated generate VBN cord-262248-q5eijunp 47 25 , , , cord-262248-q5eijunp 47 26 in in IN cord-262248-q5eijunp 47 27 months month NNS cord-262248-q5eijunp 47 28 [ [ -LRB- cord-262248-q5eijunp 47 29 17 17 CD cord-262248-q5eijunp 47 30 ] ] -RRB- cord-262248-q5eijunp 47 31 , , , cord-262248-q5eijunp 47 32 but but CC cord-262248-q5eijunp 47 33 was be VBD cord-262248-q5eijunp 47 34 not not RB cord-262248-q5eijunp 47 35 used use VBN cord-262248-q5eijunp 47 36 because because IN cord-262248-q5eijunp 47 37 the the DT cord-262248-q5eijunp 47 38 epidemic epidemic NN cord-262248-q5eijunp 47 39 was be VBD cord-262248-q5eijunp 47 40 contained contain VBN cord-262248-q5eijunp 47 41 . . . cord-262248-q5eijunp 48 1 An an DT cord-262248-q5eijunp 48 2 even even RB cord-262248-q5eijunp 48 3 more more RBR cord-262248-q5eijunp 48 4 expedient expedient JJ cord-262248-q5eijunp 48 5 strategy strategy NN cord-262248-q5eijunp 48 6 is be VBZ cord-262248-q5eijunp 48 7 to to TO cord-262248-q5eijunp 48 8 use use VB cord-262248-q5eijunp 48 9 convalescent convalescent JJ cord-262248-q5eijunp 48 10 serum serum NN cord-262248-q5eijunp 48 11 from from IN cord-262248-q5eijunp 48 12 survivors survivor NNS cord-262248-q5eijunp 48 13 in in IN cord-262248-q5eijunp 48 14 an an DT cord-262248-q5eijunp 48 15 epidemic epidemic NN cord-262248-q5eijunp 48 16 as as IN cord-262248-q5eijunp 48 17 a a DT cord-262248-q5eijunp 48 18 source source NN cord-262248-q5eijunp 48 19 of of IN cord-262248-q5eijunp 48 20 antibodies antibody NNS cord-262248-q5eijunp 48 21 to to TO cord-262248-q5eijunp 48 22 treat treat VB cord-262248-q5eijunp 48 23 those those DT cord-262248-q5eijunp 48 24 at at IN cord-262248-q5eijunp 48 25 risk risk NN cord-262248-q5eijunp 48 26 and and CC cord-262248-q5eijunp 48 27 with with IN cord-262248-q5eijunp 48 28 concurrent concurrent JJ cord-262248-q5eijunp 48 29 disease disease NN cord-262248-q5eijunp 48 30 . . . cord-262248-q5eijunp 49 1 In in IN cord-262248-q5eijunp 49 2 the the DT cord-262248-q5eijunp 49 3 past past NN cord-262248-q5eijunp 49 4 , , , cord-262248-q5eijunp 49 5 convalescent convalescent NNP cord-262248-q5eijunp 49 6 sera sera NNP cord-262248-q5eijunp 49 7 was be VBD cord-262248-q5eijunp 49 8 used use VBN cord-262248-q5eijunp 49 9 to to TO cord-262248-q5eijunp 49 10 treat treat VB cord-262248-q5eijunp 49 11 influenza influenza NN cord-262248-q5eijunp 49 12 and and CC cord-262248-q5eijunp 49 13 Ebola Ebola NNP cord-262248-q5eijunp 49 14 virus virus NN cord-262248-q5eijunp 49 15 disease disease NN cord-262248-q5eijunp 49 16 [ [ -LRB- cord-262248-q5eijunp 49 17 18 18 CD cord-262248-q5eijunp 49 18 , , , cord-262248-q5eijunp 49 19 19 19 CD cord-262248-q5eijunp 49 20 ] ] -RRB- cord-262248-q5eijunp 49 21 . . . cord-262248-q5eijunp 50 1 Today today NN cord-262248-q5eijunp 50 2 , , , cord-262248-q5eijunp 50 3 convalescent convalescent JJ cord-262248-q5eijunp 50 4 sera sera NNP cord-262248-q5eijunp 50 5 from from IN cord-262248-q5eijunp 50 6 survivors survivor NNS cord-262248-q5eijunp 50 7 of of IN cord-262248-q5eijunp 50 8 Ebola Ebola NNP cord-262248-q5eijunp 50 9 virus virus NN cord-262248-q5eijunp 50 10 disease disease NN cord-262248-q5eijunp 50 11 has have VBZ cord-262248-q5eijunp 50 12 reportedly reportedly RB cord-262248-q5eijunp 50 13 been be VBN cord-262248-q5eijunp 50 14 used use VBN cord-262248-q5eijunp 50 15 to to TO cord-262248-q5eijunp 50 16 treat treat VB cord-262248-q5eijunp 50 17 cases case NNS cord-262248-q5eijunp 50 18 , , , cord-262248-q5eijunp 50 19 although although IN cord-262248-q5eijunp 50 20 details detail NNS cord-262248-q5eijunp 50 21 of of IN cord-262248-q5eijunp 50 22 how how WRB cord-262248-q5eijunp 50 23 the the DT cord-262248-q5eijunp 50 24 sera sera NNP cord-262248-q5eijunp 50 25 have have VBP cord-262248-q5eijunp 50 26 been be VBN cord-262248-q5eijunp 50 27 used use VBN cord-262248-q5eijunp 50 28 and and CC cord-262248-q5eijunp 50 29 evidence evidence NN cord-262248-q5eijunp 50 30 of of IN cord-262248-q5eijunp 50 31 their -PRON- PRP$ cord-262248-q5eijunp 50 32 efficacy efficacy NN cord-262248-q5eijunp 50 33 is be VBZ cord-262248-q5eijunp 50 34 anecdotal anecdotal JJ cord-262248-q5eijunp 50 35 . . . cord-262248-q5eijunp 51 1 Nonetheless nonetheless RB cord-262248-q5eijunp 51 2 , , , cord-262248-q5eijunp 51 3 we -PRON- PRP cord-262248-q5eijunp 51 4 note note VBP cord-262248-q5eijunp 51 5 that that IN cord-262248-q5eijunp 51 6 there there EX cord-262248-q5eijunp 51 7 are be VBP cord-262248-q5eijunp 51 8 at at RB cord-262248-q5eijunp 51 9 least least RBS cord-262248-q5eijunp 51 10 three three CD cord-262248-q5eijunp 51 11 established establish VBN cord-262248-q5eijunp 51 12 mechanisms mechanism NNS cord-262248-q5eijunp 51 13 of of IN cord-262248-q5eijunp 51 14 antibody antibody NN cord-262248-q5eijunp 51 15 function function NN cord-262248-q5eijunp 51 16 that that WDT cord-262248-q5eijunp 51 17 could could MD cord-262248-q5eijunp 51 18 benefit benefit VB cord-262248-q5eijunp 51 19 patients patient NNS cord-262248-q5eijunp 51 20 with with IN cord-262248-q5eijunp 51 21 Ebola Ebola NNP cord-262248-q5eijunp 51 22 : : : cord-262248-q5eijunp 51 23 direct direct JJ cord-262248-q5eijunp 51 24 neutralization neutralization NN cord-262248-q5eijunp 51 25 of of IN cord-262248-q5eijunp 51 26 Ebola Ebola NNP cord-262248-q5eijunp 51 27 virus virus NN cord-262248-q5eijunp 51 28 , , , cord-262248-q5eijunp 51 29 enhancement enhancement NN cord-262248-q5eijunp 51 30 of of IN cord-262248-q5eijunp 51 31 Ebola Ebola NNP cord-262248-q5eijunp 51 32 virus virus NN cord-262248-q5eijunp 51 33 uptake uptake NN cord-262248-q5eijunp 51 34 and/or and/or CC cord-262248-q5eijunp 51 35 killing kill VBG cord-262248-q5eijunp 51 36 by by IN cord-262248-q5eijunp 51 37 phagocytes phagocyte NNS cord-262248-q5eijunp 51 38 , , , cord-262248-q5eijunp 51 39 and and CC cord-262248-q5eijunp 51 40 modulation modulation NN cord-262248-q5eijunp 51 41 of of IN cord-262248-q5eijunp 51 42 Ebola Ebola NNP cord-262248-q5eijunp 51 43 - - HYPH cord-262248-q5eijunp 51 44 virus virus NN cord-262248-q5eijunp 51 45 - - HYPH cord-262248-q5eijunp 51 46 induced induce VBN cord-262248-q5eijunp 51 47 inflammatory inflammatory JJ cord-262248-q5eijunp 51 48 response response NN cord-262248-q5eijunp 51 49 . . . cord-262248-q5eijunp 52 1 Regarding regard VBG cord-262248-q5eijunp 52 2 the the DT cord-262248-q5eijunp 52 3 latter latter JJ cord-262248-q5eijunp 52 4 , , , cord-262248-q5eijunp 52 5 it -PRON- PRP cord-262248-q5eijunp 52 6 is be VBZ cord-262248-q5eijunp 52 7 of of IN cord-262248-q5eijunp 52 8 interest interest NN cord-262248-q5eijunp 52 9 that that IN cord-262248-q5eijunp 52 10 immunomodulation immunomodulation NN cord-262248-q5eijunp 52 11 has have VBZ cord-262248-q5eijunp 52 12 been be VBN cord-262248-q5eijunp 52 13 proposed propose VBN cord-262248-q5eijunp 52 14 as as IN cord-262248-q5eijunp 52 15 an an DT cord-262248-q5eijunp 52 16 intervention intervention NN cord-262248-q5eijunp 52 17 for for IN cord-262248-q5eijunp 52 18 Ebola Ebola NNP cord-262248-q5eijunp 52 19 virus virus NN cord-262248-q5eijunp 52 20 [ [ -LRB- cord-262248-q5eijunp 52 21 20 20 CD cord-262248-q5eijunp 52 22 ] ] -RRB- cord-262248-q5eijunp 52 23 and and CC cord-262248-q5eijunp 52 24 anecdotal anecdotal JJ cord-262248-q5eijunp 52 25 reports report NNS cord-262248-q5eijunp 52 26 suggest suggest VBP cord-262248-q5eijunp 52 27 that that DT cord-262248-q5eijunp 52 28 control control NN cord-262248-q5eijunp 52 29 of of IN cord-262248-q5eijunp 52 30 Ebola Ebola NNP cord-262248-q5eijunp 52 31 - - HYPH cord-262248-q5eijunp 52 32 virus virus NN cord-262248-q5eijunp 52 33 - - HYPH cord-262248-q5eijunp 52 34 induced induce VBN cord-262248-q5eijunp 52 35 cytokine cytokine NN cord-262248-q5eijunp 52 36 storm storm NN cord-262248-q5eijunp 52 37 might may MD cord-262248-q5eijunp 52 38 be be VB cord-262248-q5eijunp 52 39 beneficial beneficial JJ cord-262248-q5eijunp 52 40 therapeutically therapeutically RB cord-262248-q5eijunp 52 41 . . . cord-262248-q5eijunp 53 1 Despite despite IN cord-262248-q5eijunp 53 2 having have VBG cord-262248-q5eijunp 53 3 pioneered pioneer VBN cord-262248-q5eijunp 53 4 the the DT cord-262248-q5eijunp 53 5 use use NN cord-262248-q5eijunp 53 6 of of IN cord-262248-q5eijunp 53 7 Ab Ab NNP cord-262248-q5eijunp 53 8 therapy therapy NN cord-262248-q5eijunp 53 9 , , , cord-262248-q5eijunp 53 10 the the DT cord-262248-q5eijunp 53 11 use use NN cord-262248-q5eijunp 53 12 of of IN cord-262248-q5eijunp 53 13 Ab ab NN cord-262248-q5eijunp 53 14 - - HYPH cord-262248-q5eijunp 53 15 based base VBN cord-262248-q5eijunp 53 16 therapies therapy NNS cord-262248-q5eijunp 53 17 in in IN cord-262248-q5eijunp 53 18 the the DT cord-262248-q5eijunp 53 19 field field NN cord-262248-q5eijunp 53 20 of of IN cord-262248-q5eijunp 53 21 infectious infectious JJ cord-262248-q5eijunp 53 22 diseases disease NNS cord-262248-q5eijunp 53 23 remains remain VBZ cord-262248-q5eijunp 53 24 a a DT cord-262248-q5eijunp 53 25 work work NN cord-262248-q5eijunp 53 26 in in IN cord-262248-q5eijunp 53 27 progress progress NN cord-262248-q5eijunp 53 28 despite despite IN cord-262248-q5eijunp 53 29 enormous enormous JJ cord-262248-q5eijunp 53 30 technological technological JJ cord-262248-q5eijunp 53 31 progress progress NN cord-262248-q5eijunp 53 32 in in IN cord-262248-q5eijunp 53 33 Ab Ab NNP cord-262248-q5eijunp 53 34 engineering engineering NN cord-262248-q5eijunp 53 35 and and CC cord-262248-q5eijunp 53 36 production production NN cord-262248-q5eijunp 53 37 . . . cord-262248-q5eijunp 54 1 In in IN cord-262248-q5eijunp 54 2 contrast contrast NN cord-262248-q5eijunp 54 3 to to IN cord-262248-q5eijunp 54 4 oncology oncology NN cord-262248-q5eijunp 54 5 and and CC cord-262248-q5eijunp 54 6 rheumatology rheumatology NN cord-262248-q5eijunp 54 7 , , , cord-262248-q5eijunp 54 8 where where WRB cord-262248-q5eijunp 54 9 Ab Ab NNP cord-262248-q5eijunp 54 10 therapies therapy NNS cord-262248-q5eijunp 54 11 are be VBP cord-262248-q5eijunp 54 12 now now RB cord-262248-q5eijunp 54 13 common common JJ cord-262248-q5eijunp 54 14 , , , cord-262248-q5eijunp 54 15 there there EX cord-262248-q5eijunp 54 16 are be VBP cord-262248-q5eijunp 54 17 only only RB cord-262248-q5eijunp 54 18 two two CD cord-262248-q5eijunp 54 19 licensed license VBN cord-262248-q5eijunp 54 20 mAbs mabs NN cord-262248-q5eijunp 54 21 for for IN cord-262248-q5eijunp 54 22 infectious infectious JJ cord-262248-q5eijunp 54 23 diseases disease NNS cord-262248-q5eijunp 54 24 : : : cord-262248-q5eijunp 54 25 one one CD cord-262248-q5eijunp 54 26 for for IN cord-262248-q5eijunp 54 27 the the DT cord-262248-q5eijunp 54 28 prevention prevention NN cord-262248-q5eijunp 54 29 of of IN cord-262248-q5eijunp 54 30 respiratory respiratory JJ cord-262248-q5eijunp 54 31 syncytial syncytial JJ cord-262248-q5eijunp 54 32 virus virus NN cord-262248-q5eijunp 54 33 infection infection NN cord-262248-q5eijunp 54 34 and and CC cord-262248-q5eijunp 54 35 the the DT cord-262248-q5eijunp 54 36 other other JJ cord-262248-q5eijunp 54 37 for for IN cord-262248-q5eijunp 54 38 the the DT cord-262248-q5eijunp 54 39 therapy therapy NN cord-262248-q5eijunp 54 40 of of IN cord-262248-q5eijunp 54 41 anthrax anthrax NN cord-262248-q5eijunp 54 42 . . . cord-262248-q5eijunp 55 1 Hence hence RB cord-262248-q5eijunp 55 2 , , , cord-262248-q5eijunp 55 3 Ab Ab NNP cord-262248-q5eijunp 55 4 - - HYPH cord-262248-q5eijunp 55 5 based base VBN cord-262248-q5eijunp 55 6 therapies therapy NNS cord-262248-q5eijunp 55 7 are be VBP cord-262248-q5eijunp 55 8 severely severely RB cord-262248-q5eijunp 55 9 underdeveloped underdeveloped JJ cord-262248-q5eijunp 55 10 for for IN cord-262248-q5eijunp 55 11 the the DT cord-262248-q5eijunp 55 12 treatment treatment NN cord-262248-q5eijunp 55 13 of of IN cord-262248-q5eijunp 55 14 infectious infectious JJ cord-262248-q5eijunp 55 15 diseases disease NNS cord-262248-q5eijunp 55 16 . . . cord-262248-q5eijunp 56 1 Although although IN cord-262248-q5eijunp 56 2 the the DT cord-262248-q5eijunp 56 3 causes cause NNS cord-262248-q5eijunp 56 4 for for IN cord-262248-q5eijunp 56 5 this this DT cord-262248-q5eijunp 56 6 are be VBP cord-262248-q5eijunp 56 7 complex complex JJ cord-262248-q5eijunp 56 8 , , , cord-262248-q5eijunp 56 9 we -PRON- PRP cord-262248-q5eijunp 56 10 identify identify VBP cord-262248-q5eijunp 56 11 five five CD cord-262248-q5eijunp 56 12 factors factor NNS cord-262248-q5eijunp 56 13 that that WDT cord-262248-q5eijunp 56 14 are be VBP cord-262248-q5eijunp 56 15 , , , cord-262248-q5eijunp 56 16 in in IN cord-262248-q5eijunp 56 17 some some DT cord-262248-q5eijunp 56 18 cases case NNS cord-262248-q5eijunp 56 19 , , , cord-262248-q5eijunp 56 20 interrelated interrelated JJ cord-262248-q5eijunp 56 21 and and CC cord-262248-q5eijunp 56 22 , , , cord-262248-q5eijunp 56 23 yet yet CC cord-262248-q5eijunp 56 24 , , , cord-262248-q5eijunp 56 25 all all DT cord-262248-q5eijunp 56 26 work work NN cord-262248-q5eijunp 56 27 in in IN cord-262248-q5eijunp 56 28 synergy synergy NN cord-262248-q5eijunp 56 29 to to TO cord-262248-q5eijunp 56 30 hinder hinder VB cord-262248-q5eijunp 56 31 the the DT cord-262248-q5eijunp 56 32 widespread widespread JJ cord-262248-q5eijunp 56 33 reintroduction reintroduction NN cord-262248-q5eijunp 56 34 of of IN cord-262248-q5eijunp 56 35 Ab Ab NNP cord-262248-q5eijunp 56 36 therapies therapy NNS cord-262248-q5eijunp 56 37 to to IN cord-262248-q5eijunp 56 38 this this DT cord-262248-q5eijunp 56 39 field field NN cord-262248-q5eijunp 56 40 . . . cord-262248-q5eijunp 57 1 i. i. NNP cord-262248-q5eijunp 57 2 Cost Cost NNP cord-262248-q5eijunp 57 3 . . . cord-262248-q5eijunp 58 1 Ab Ab NNP cord-262248-q5eijunp 58 2 therapies therapy NNS cord-262248-q5eijunp 58 3 are be VBP cord-262248-q5eijunp 58 4 generally generally RB cord-262248-q5eijunp 58 5 significantly significantly RB cord-262248-q5eijunp 58 6 more more RBR cord-262248-q5eijunp 58 7 expensive expensive JJ cord-262248-q5eijunp 58 8 than than IN cord-262248-q5eijunp 58 9 small small JJ cord-262248-q5eijunp 58 10 molecules molecule NNS cord-262248-q5eijunp 58 11 because because IN cord-262248-q5eijunp 58 12 they -PRON- PRP cord-262248-q5eijunp 58 13 must must MD cord-262248-q5eijunp 58 14 be be VB cord-262248-q5eijunp 58 15 produced produce VBN cord-262248-q5eijunp 58 16 in in IN cord-262248-q5eijunp 58 17 animals animal NNS cord-262248-q5eijunp 58 18 or or CC cord-262248-q5eijunp 58 19 cell cell NN cord-262248-q5eijunp 58 20 culture culture NN cord-262248-q5eijunp 58 21 . . . cord-262248-q5eijunp 59 1 Immunoglobulins immunoglobulin NNS cord-262248-q5eijunp 59 2 are be VBP cord-262248-q5eijunp 59 3 proteins protein NNS cord-262248-q5eijunp 59 4 that that WDT cord-262248-q5eijunp 59 5 require require VBP cord-262248-q5eijunp 59 6 refrigeration refrigeration NN cord-262248-q5eijunp 59 7 for for IN cord-262248-q5eijunp 59 8 storage storage NN cord-262248-q5eijunp 59 9 , , , cord-262248-q5eijunp 59 10 which which WDT cord-262248-q5eijunp 59 11 , , , cord-262248-q5eijunp 59 12 in in IN cord-262248-q5eijunp 59 13 turn turn NN cord-262248-q5eijunp 59 14 , , , cord-262248-q5eijunp 59 15 increases increase VBZ cord-262248-q5eijunp 59 16 their -PRON- PRP$ cord-262248-q5eijunp 59 17 cost cost NN cord-262248-q5eijunp 59 18 . . . cord-262248-q5eijunp 60 1 However however RB cord-262248-q5eijunp 60 2 , , , cord-262248-q5eijunp 60 3 when when WRB cord-262248-q5eijunp 60 4 one one PRP cord-262248-q5eijunp 60 5 considers consider VBZ cord-262248-q5eijunp 60 6 the the DT cord-262248-q5eijunp 60 7 costs cost NNS cord-262248-q5eijunp 60 8 of of IN cord-262248-q5eijunp 60 9 antibiotic antibiotic JJ cord-262248-q5eijunp 60 10 - - HYPH cord-262248-q5eijunp 60 11 associated associate VBN cord-262248-q5eijunp 60 12 colitis colitis NN cord-262248-q5eijunp 60 13 , , , cord-262248-q5eijunp 60 14 damage damage NN cord-262248-q5eijunp 60 15 to to IN cord-262248-q5eijunp 60 16 the the DT cord-262248-q5eijunp 60 17 microbiota microbiota NN cord-262248-q5eijunp 60 18 , , , cord-262248-q5eijunp 60 19 resistance resistance NN cord-262248-q5eijunp 60 20 in in IN cord-262248-q5eijunp 60 21 non non JJ cord-262248-q5eijunp 60 22 - - JJ cord-262248-q5eijunp 60 23 targeted target VBN cord-262248-q5eijunp 60 24 organisms organism NNS cord-262248-q5eijunp 60 25 , , , cord-262248-q5eijunp 60 26 and and CC cord-262248-q5eijunp 60 27 superinfections superinfection NNS cord-262248-q5eijunp 60 28 resulting result VBG cord-262248-q5eijunp 60 29 from from IN cord-262248-q5eijunp 60 30 non non JJ cord-262248-q5eijunp 60 31 - - JJ cord-262248-q5eijunp 60 32 specific specific JJ cord-262248-q5eijunp 60 33 therapy therapy NN cord-262248-q5eijunp 60 34 , , , cord-262248-q5eijunp 60 35 the the DT cord-262248-q5eijunp 60 36 cost cost NN cord-262248-q5eijunp 60 37 accounting accounting NN cord-262248-q5eijunp 60 38 may may MD cord-262248-q5eijunp 60 39 be be VB cord-262248-q5eijunp 60 40 more more RBR cord-262248-q5eijunp 60 41 favorable favorable JJ cord-262248-q5eijunp 60 42 for for IN cord-262248-q5eijunp 60 43 Ab ab NN cord-262248-q5eijunp 60 44 therapy therapy NN cord-262248-q5eijunp 60 45 . . . cord-262248-q5eijunp 61 1 ii ii NNP cord-262248-q5eijunp 61 2 . . . cord-262248-q5eijunp 62 1 Specificity specificity NN cord-262248-q5eijunp 62 2 . . . cord-262248-q5eijunp 63 1 As as IN cord-262248-q5eijunp 63 2 alluded allude VBN cord-262248-q5eijunp 63 3 to to IN cord-262248-q5eijunp 63 4 above above RB cord-262248-q5eijunp 63 5 , , , cord-262248-q5eijunp 63 6 the the DT cord-262248-q5eijunp 63 7 specificity specificity NN cord-262248-q5eijunp 63 8 of of IN cord-262248-q5eijunp 63 9 Ab Ab NNP cord-262248-q5eijunp 63 10 therapies therapy NNS cord-262248-q5eijunp 63 11 means mean VBZ cord-262248-q5eijunp 63 12 that that IN cord-262248-q5eijunp 63 13 they -PRON- PRP cord-262248-q5eijunp 63 14 are be VBP cord-262248-q5eijunp 63 15 pathogen pathogen NN cord-262248-q5eijunp 63 16 specific specific JJ cord-262248-q5eijunp 63 17 and and CC cord-262248-q5eijunp 63 18 often often RB cord-262248-q5eijunp 63 19 target target VBP cord-262248-q5eijunp 63 20 a a DT cord-262248-q5eijunp 63 21 subgroup subgroup NN cord-262248-q5eijunp 63 22 of of IN cord-262248-q5eijunp 63 23 organisms organism NNS cord-262248-q5eijunp 63 24 within within IN cord-262248-q5eijunp 63 25 a a DT cord-262248-q5eijunp 63 26 pathogenic pathogenic JJ cord-262248-q5eijunp 63 27 species specie NNS cord-262248-q5eijunp 63 28 . . . cord-262248-q5eijunp 64 1 This this DT cord-262248-q5eijunp 64 2 limitation limitation NN cord-262248-q5eijunp 64 3 can can MD cord-262248-q5eijunp 64 4 be be VB cord-262248-q5eijunp 64 5 bypassed bypass VBN cord-262248-q5eijunp 64 6 by by IN cord-262248-q5eijunp 64 7 creating create VBG cord-262248-q5eijunp 64 8 mAb mab NN cord-262248-q5eijunp 64 9 cocktails cocktail NNS cord-262248-q5eijunp 64 10 , , , cord-262248-q5eijunp 64 11 but but CC cord-262248-q5eijunp 64 12 that that IN cord-262248-q5eijunp 64 13 , , , cord-262248-q5eijunp 64 14 in in IN cord-262248-q5eijunp 64 15 turn turn NN cord-262248-q5eijunp 64 16 , , , cord-262248-q5eijunp 64 17 increases increase VBZ cord-262248-q5eijunp 64 18 the the DT cord-262248-q5eijunp 64 19 complexity complexity NN cord-262248-q5eijunp 64 20 of of IN cord-262248-q5eijunp 64 21 production production NN cord-262248-q5eijunp 64 22 and and CC cord-262248-q5eijunp 64 23 cost cost NN cord-262248-q5eijunp 64 24 . . . cord-262248-q5eijunp 65 1 In in IN cord-262248-q5eijunp 65 2 addition addition NN cord-262248-q5eijunp 65 3 , , , cord-262248-q5eijunp 65 4 cocktails cocktail NNS cord-262248-q5eijunp 65 5 could could MD cord-262248-q5eijunp 65 6 face face VB cord-262248-q5eijunp 65 7 more more RBR cord-262248-q5eijunp 65 8 complicated complicated JJ cord-262248-q5eijunp 65 9 regulatory regulatory JJ cord-262248-q5eijunp 65 10 hurdles hurdle NNS cord-262248-q5eijunp 65 11 than than IN cord-262248-q5eijunp 65 12 therapies therapy NNS cord-262248-q5eijunp 65 13 composed compose VBN cord-262248-q5eijunp 65 14 of of IN cord-262248-q5eijunp 65 15 a a DT cord-262248-q5eijunp 65 16 single single JJ cord-262248-q5eijunp 65 17 active active JJ cord-262248-q5eijunp 65 18 agent agent NN cord-262248-q5eijunp 65 19 . . . cord-262248-q5eijunp 66 1 Despite despite IN cord-262248-q5eijunp 66 2 this this DT cord-262248-q5eijunp 66 3 , , , cord-262248-q5eijunp 66 4 we -PRON- PRP cord-262248-q5eijunp 66 5 note note VBP cord-262248-q5eijunp 66 6 that that IN cord-262248-q5eijunp 66 7 mAb mab NN cord-262248-q5eijunp 66 8 cocktails cocktail NNS cord-262248-q5eijunp 66 9 are be VBP cord-262248-q5eijunp 66 10 being be VBG cord-262248-q5eijunp 66 11 developed develop VBN cord-262248-q5eijunp 66 12 against against IN cord-262248-q5eijunp 66 13 Ebola Ebola NNP cord-262248-q5eijunp 66 14 virus virus NN cord-262248-q5eijunp 66 15 , , , cord-262248-q5eijunp 66 16 C. C. NNP cord-262248-q5eijunp 66 17 difficile difficile NN cord-262248-q5eijunp 66 18 colitis colitis NN cord-262248-q5eijunp 66 19 , , , cord-262248-q5eijunp 66 20 and and CC cord-262248-q5eijunp 66 21 for for IN cord-262248-q5eijunp 66 22 the the DT cord-262248-q5eijunp 66 23 prevention prevention NN cord-262248-q5eijunp 66 24 of of IN cord-262248-q5eijunp 66 25 rabies rabie NNS cord-262248-q5eijunp 66 26 . . . cord-262248-q5eijunp 67 1 iii iii NNP cord-262248-q5eijunp 67 2 . . . cord-262248-q5eijunp 68 1 Market market NN cord-262248-q5eijunp 68 2 size size NN cord-262248-q5eijunp 68 3 and and CC cord-262248-q5eijunp 68 4 profitability profitability NN cord-262248-q5eijunp 68 5 . . . cord-262248-q5eijunp 69 1 The the DT cord-262248-q5eijunp 69 2 antimicrobial antimicrobial JJ cord-262248-q5eijunp 69 3 spectrum spectrum NN cord-262248-q5eijunp 69 4 of of IN cord-262248-q5eijunp 69 5 a a DT cord-262248-q5eijunp 69 6 drug drug NN cord-262248-q5eijunp 69 7 combined combine VBN cord-262248-q5eijunp 69 8 with with IN cord-262248-q5eijunp 69 9 the the DT cord-262248-q5eijunp 69 10 prevalence prevalence NN cord-262248-q5eijunp 69 11 of of IN cord-262248-q5eijunp 69 12 disease disease NN cord-262248-q5eijunp 69 13 caused cause VBN cord-262248-q5eijunp 69 14 by by IN cord-262248-q5eijunp 69 15 the the DT cord-262248-q5eijunp 69 16 organisms organism NNS cord-262248-q5eijunp 69 17 for for IN cord-262248-q5eijunp 69 18 which which WDT cord-262248-q5eijunp 69 19 it -PRON- PRP cord-262248-q5eijunp 69 20 has have VBZ cord-262248-q5eijunp 69 21 efficacy efficacy NN cord-262248-q5eijunp 69 22 determines determine VBZ cord-262248-q5eijunp 69 23 its -PRON- PRP$ cord-262248-q5eijunp 69 24 market market NN cord-262248-q5eijunp 69 25 size size NN cord-262248-q5eijunp 69 26 . . . cord-262248-q5eijunp 70 1 This this DT cord-262248-q5eijunp 70 2 law law NN cord-262248-q5eijunp 70 3 of of IN cord-262248-q5eijunp 70 4 pharmaceutical pharmaceutical JJ cord-262248-q5eijunp 70 5 economics economic NNS cord-262248-q5eijunp 70 6 has have VBZ cord-262248-q5eijunp 70 7 favored favor VBN cord-262248-q5eijunp 70 8 the the DT cord-262248-q5eijunp 70 9 development development NN cord-262248-q5eijunp 70 10 of of IN cord-262248-q5eijunp 70 11 broadspectrum broadspectrum NNP cord-262248-q5eijunp 70 12 therapies therapy NNS cord-262248-q5eijunp 70 13 that that WDT cord-262248-q5eijunp 70 14 are be VBP cord-262248-q5eijunp 70 15 responsible responsible JJ cord-262248-q5eijunp 70 16 for for IN cord-262248-q5eijunp 70 17 widespread widespread JJ cord-262248-q5eijunp 70 18 resistance resistance NN cord-262248-q5eijunp 70 19 and and CC cord-262248-q5eijunp 70 20 deleterious deleterious JJ cord-262248-q5eijunp 70 21 effects effect NNS cord-262248-q5eijunp 70 22 of of IN cord-262248-q5eijunp 70 23 Ab Ab NNP cord-262248-q5eijunp 70 24 therapies therapy NNS cord-262248-q5eijunp 70 25 on on IN cord-262248-q5eijunp 70 26 host host NN cord-262248-q5eijunp 70 27 microbiota microbiota NN cord-262248-q5eijunp 70 28 . . . cord-262248-q5eijunp 71 1 Hence hence RB cord-262248-q5eijunp 71 2 , , , cord-262248-q5eijunp 71 3 the the DT cord-262248-q5eijunp 71 4 exquisite exquisite JJ cord-262248-q5eijunp 71 5 specificity specificity NN cord-262248-q5eijunp 71 6 of of IN cord-262248-q5eijunp 71 7 mAb mab NN cord-262248-q5eijunp 71 8 - - HYPH cord-262248-q5eijunp 71 9 based base VBN cord-262248-q5eijunp 71 10 drugs drug NNS cord-262248-q5eijunp 71 11 de de FW cord-262248-q5eijunp 71 12 facto facto FW cord-262248-q5eijunp 71 13 means mean VBZ cord-262248-q5eijunp 71 14 smaller small JJR cord-262248-q5eijunp 71 15 market market NN cord-262248-q5eijunp 71 16 sizes size NNS cord-262248-q5eijunp 71 17 , , , cord-262248-q5eijunp 71 18 which which WDT cord-262248-q5eijunp 71 19 , , , cord-262248-q5eijunp 71 20 in in IN cord-262248-q5eijunp 71 21 turn turn NN cord-262248-q5eijunp 71 22 , , , cord-262248-q5eijunp 71 23 increases increase VBZ cord-262248-q5eijunp 71 24 costs cost NNS cord-262248-q5eijunp 71 25 , , , cord-262248-q5eijunp 71 26 reduces reduce VBZ cord-262248-q5eijunp 71 27 profitability profitability NN cord-262248-q5eijunp 71 28 , , , cord-262248-q5eijunp 71 29 and and CC cord-262248-q5eijunp 71 30 makes make VBZ cord-262248-q5eijunp 71 31 these these DT cord-262248-q5eijunp 71 32 reagents reagent NNS cord-262248-q5eijunp 71 33 suitable suitable JJ cord-262248-q5eijunp 71 34 for for IN cord-262248-q5eijunp 71 35 treating treat VBG cord-262248-q5eijunp 71 36 specific specific JJ cord-262248-q5eijunp 71 37 diseases disease NNS cord-262248-q5eijunp 71 38 unattractive unattractive JJ cord-262248-q5eijunp 71 39 to to IN cord-262248-q5eijunp 71 40 industry industry NN cord-262248-q5eijunp 71 41 . . . cord-262248-q5eijunp 72 1 iv iv LS cord-262248-q5eijunp 72 2 . . . cord-262248-q5eijunp 73 1 The the DT cord-262248-q5eijunp 73 2 availability availability NN cord-262248-q5eijunp 73 3 of of IN cord-262248-q5eijunp 73 4 existing exist VBG cord-262248-q5eijunp 73 5 therapies therapy NNS cord-262248-q5eijunp 73 6 . . . cord-262248-q5eijunp 74 1 For for IN cord-262248-q5eijunp 74 2 many many JJ cord-262248-q5eijunp 74 3 infectious infectious JJ cord-262248-q5eijunp 74 4 diseases disease NNS cord-262248-q5eijunp 74 5 , , , cord-262248-q5eijunp 74 6 the the DT cord-262248-q5eijunp 74 7 current current JJ cord-262248-q5eijunp 74 8 availability availability NN cord-262248-q5eijunp 74 9 of of IN cord-262248-q5eijunp 74 10 effective effective JJ cord-262248-q5eijunp 74 11 therapy therapy NN cord-262248-q5eijunp 74 12 means mean VBZ cord-262248-q5eijunp 74 13 that that IN cord-262248-q5eijunp 74 14 any any DT cord-262248-q5eijunp 74 15 attempt attempt NN cord-262248-q5eijunp 74 16 to to TO cord-262248-q5eijunp 74 17 develop develop VB cord-262248-q5eijunp 74 18 Ab Ab NNP cord-262248-q5eijunp 74 19 therapy therapy NN cord-262248-q5eijunp 74 20 involves involve VBZ cord-262248-q5eijunp 74 21 establishing establish VBG cord-262248-q5eijunp 74 22 the the DT cord-262248-q5eijunp 74 23 advantage advantage NN cord-262248-q5eijunp 74 24 of of IN cord-262248-q5eijunp 74 25 such such JJ cord-262248-q5eijunp 74 26 therapies therapy NNS cord-262248-q5eijunp 74 27 either either CC cord-262248-q5eijunp 74 28 alone alone RB cord-262248-q5eijunp 74 29 or or CC cord-262248-q5eijunp 74 30 in in IN cord-262248-q5eijunp 74 31 combination combination NN cord-262248-q5eijunp 74 32 with with IN cord-262248-q5eijunp 74 33 existing exist VBG cord-262248-q5eijunp 74 34 therapies therapy NNS cord-262248-q5eijunp 74 35 , , , cord-262248-q5eijunp 74 36 and and CC cord-262248-q5eijunp 74 37 this this DT cord-262248-q5eijunp 74 38 greatly greatly RB cord-262248-q5eijunp 74 39 complicates complicate VBZ cord-262248-q5eijunp 74 40 clinical clinical JJ cord-262248-q5eijunp 74 41 development development NN cord-262248-q5eijunp 74 42 and and CC cord-262248-q5eijunp 74 43 marketing marketing NN cord-262248-q5eijunp 74 44 . . . cord-262248-q5eijunp 75 1 In in IN cord-262248-q5eijunp 75 2 other other JJ cord-262248-q5eijunp 75 3 fields field NNS cord-262248-q5eijunp 75 4 , , , cord-262248-q5eijunp 75 5 where where WRB cord-262248-q5eijunp 75 6 no no DT cord-262248-q5eijunp 75 7 therapy therapy NN cord-262248-q5eijunp 75 8 was be VBD cord-262248-q5eijunp 75 9 available available JJ cord-262248-q5eijunp 75 10 , , , cord-262248-q5eijunp 75 11 the the DT cord-262248-q5eijunp 75 12 development development NN cord-262248-q5eijunp 75 13 of of IN cord-262248-q5eijunp 75 14 Ab Ab NNP cord-262248-q5eijunp 75 15 therapies therapy NNS cord-262248-q5eijunp 75 16 was be VBD cord-262248-q5eijunp 75 17 easier easy JJR cord-262248-q5eijunp 75 18 because because IN cord-262248-q5eijunp 75 19 it -PRON- PRP cord-262248-q5eijunp 75 20 provided provide VBD cord-262248-q5eijunp 75 21 something something NN cord-262248-q5eijunp 75 22 new new JJ cord-262248-q5eijunp 75 23 . . . cord-262248-q5eijunp 76 1 However however RB cord-262248-q5eijunp 76 2 , , , cord-262248-q5eijunp 76 3 this this DT cord-262248-q5eijunp 76 4 situation situation NN cord-262248-q5eijunp 76 5 may may MD cord-262248-q5eijunp 76 6 change change VB cord-262248-q5eijunp 76 7 since since IN cord-262248-q5eijunp 76 8 the the DT cord-262248-q5eijunp 76 9 declining decline VBG cord-262248-q5eijunp 76 10 efficacy efficacy NN cord-262248-q5eijunp 76 11 of of IN cord-262248-q5eijunp 76 12 conventional conventional JJ cord-262248-q5eijunp 76 13 antimicrobial antimicrobial JJ cord-262248-q5eijunp 76 14 therapies therapy NNS cord-262248-q5eijunp 76 15 due due JJ cord-262248-q5eijunp 76 16 to to IN cord-262248-q5eijunp 76 17 widespread widespread JJ cord-262248-q5eijunp 76 18 resistance resistance NN cord-262248-q5eijunp 76 19 could could MD cord-262248-q5eijunp 76 20 create create VB cord-262248-q5eijunp 76 21 windows window NNS cord-262248-q5eijunp 76 22 for for IN cord-262248-q5eijunp 76 23 the the DT cord-262248-q5eijunp 76 24 development development NN cord-262248-q5eijunp 76 25 of of IN cord-262248-q5eijunp 76 26 Ab ab NN cord-262248-q5eijunp 76 27 - - HYPH cord-262248-q5eijunp 76 28 based base VBN cord-262248-q5eijunp 76 29 therapies therapy NNS cord-262248-q5eijunp 76 30 . . . cord-262248-q5eijunp 77 1 v. v. CC cord-262248-q5eijunp 77 2 Underdevelopment Underdevelopment NNP cord-262248-q5eijunp 77 3 in in IN cord-262248-q5eijunp 77 4 diagnostics diagnostic NNS cord-262248-q5eijunp 77 5 . . . cord-262248-q5eijunp 78 1 The the DT cord-262248-q5eijunp 78 2 specificity specificity NN cord-262248-q5eijunp 78 3 of of IN cord-262248-q5eijunp 78 4 Ab Ab NNP cord-262248-q5eijunp 78 5 therapies therapy NNS cord-262248-q5eijunp 78 6 means mean VBZ cord-262248-q5eijunp 78 7 that that IN cord-262248-q5eijunp 78 8 they -PRON- PRP cord-262248-q5eijunp 78 9 will will MD cord-262248-q5eijunp 78 10 be be VB cord-262248-q5eijunp 78 11 effective effective JJ cord-262248-q5eijunp 78 12 only only RB cord-262248-q5eijunp 78 13 in in IN cord-262248-q5eijunp 78 14 situations situation NNS cord-262248-q5eijunp 78 15 where where WRB cord-262248-q5eijunp 78 16 a a DT cord-262248-q5eijunp 78 17 precise precise JJ cord-262248-q5eijunp 78 18 microbial microbial JJ cord-262248-q5eijunp 78 19 diagnosis diagnosis NN cord-262248-q5eijunp 78 20 is be VBZ cord-262248-q5eijunp 78 21 available available JJ cord-262248-q5eijunp 78 22 . . . cord-262248-q5eijunp 79 1 For for IN cord-262248-q5eijunp 79 2 bacterial bacterial JJ cord-262248-q5eijunp 79 3 diseases disease NNS cord-262248-q5eijunp 79 4 , , , cord-262248-q5eijunp 79 5 the the DT cord-262248-q5eijunp 79 6 widespread widespread JJ cord-262248-q5eijunp 79 7 availability availability NN cord-262248-q5eijunp 79 8 of of IN cord-262248-q5eijunp 79 9 broad broad JJ cord-262248-q5eijunp 79 10 - - HYPH cord-262248-q5eijunp 79 11 spectrum spectrum NN cord-262248-q5eijunp 79 12 antimicrobial antimicrobial JJ cord-262248-q5eijunp 79 13 drugs drug NNS cord-262248-q5eijunp 79 14 with with IN cord-262248-q5eijunp 79 15 relatively relatively RB cord-262248-q5eijunp 79 16 little little JJ cord-262248-q5eijunp 79 17 toxicity toxicity NN cord-262248-q5eijunp 79 18 created create VBD cord-262248-q5eijunp 79 19 a a DT cord-262248-q5eijunp 79 20 culture culture NN cord-262248-q5eijunp 79 21 of of IN cord-262248-q5eijunp 79 22 empiricism empiricism NN cord-262248-q5eijunp 79 23 that that WDT cord-262248-q5eijunp 79 24 has have VBZ cord-262248-q5eijunp 79 25 translated translate VBN cord-262248-q5eijunp 79 26 into into IN cord-262248-q5eijunp 79 27 underdevelopment underdevelopment NN cord-262248-q5eijunp 79 28 in in IN cord-262248-q5eijunp 79 29 diagnostics diagnostic NNS cord-262248-q5eijunp 79 30 . . . cord-262248-q5eijunp 80 1 Consequently consequently RB cord-262248-q5eijunp 80 2 , , , cord-262248-q5eijunp 80 3 microbial microbial JJ cord-262248-q5eijunp 80 4 culture culture NN cord-262248-q5eijunp 80 5 has have VBZ cord-262248-q5eijunp 80 6 remained remain VBN cord-262248-q5eijunp 80 7 the the DT cord-262248-q5eijunp 80 8 gold gold NN cord-262248-q5eijunp 80 9 standard standard NN cord-262248-q5eijunp 80 10 for for IN cord-262248-q5eijunp 80 11 the the DT cord-262248-q5eijunp 80 12 diagnosis diagnosis NN cord-262248-q5eijunp 80 13 of of IN cord-262248-q5eijunp 80 14 many many JJ cord-262248-q5eijunp 80 15 infectious infectious JJ cord-262248-q5eijunp 80 16 diseases disease NNS cord-262248-q5eijunp 80 17 for for IN cord-262248-q5eijunp 80 18 decades decade NNS cord-262248-q5eijunp 80 19 despite despite IN cord-262248-q5eijunp 80 20 the the DT cord-262248-q5eijunp 80 21 availability availability NN cord-262248-q5eijunp 80 22 of of IN cord-262248-q5eijunp 80 23 new new JJ cord-262248-q5eijunp 80 24 technologies technology NNS cord-262248-q5eijunp 80 25 , , , cord-262248-q5eijunp 80 26 such such JJ cord-262248-q5eijunp 80 27 as as IN cord-262248-q5eijunp 80 28 nucleic nucleic JJ cord-262248-q5eijunp 80 29 acid acid NN cord-262248-q5eijunp 80 30 amplification amplification NN cord-262248-q5eijunp 80 31 , , , cord-262248-q5eijunp 80 32 that that WDT cord-262248-q5eijunp 80 33 could could MD cord-262248-q5eijunp 80 34 have have VB cord-262248-q5eijunp 80 35 led lead VBN cord-262248-q5eijunp 80 36 to to IN cord-262248-q5eijunp 80 37 more more RBR cord-262248-q5eijunp 80 38 rapid rapid JJ cord-262248-q5eijunp 80 39 diagnosis diagnosis NN cord-262248-q5eijunp 80 40 . . . cord-262248-q5eijunp 81 1 Fortunately fortunately RB cord-262248-q5eijunp 81 2 , , , cord-262248-q5eijunp 81 3 the the DT cord-262248-q5eijunp 81 4 situation situation NN cord-262248-q5eijunp 81 5 is be VBZ cord-262248-q5eijunp 81 6 changing change VBG cord-262248-q5eijunp 81 7 . . . cord-262248-q5eijunp 82 1 An an DT cord-262248-q5eijunp 82 2 increasing increase VBG cord-262248-q5eijunp 82 3 recognition recognition NN cord-262248-q5eijunp 82 4 of of IN cord-262248-q5eijunp 82 5 the the DT cord-262248-q5eijunp 82 6 problems problem NNS cord-262248-q5eijunp 82 7 associated associate VBN cord-262248-q5eijunp 82 8 with with IN cord-262248-q5eijunp 82 9 broadspectrum broadspectrum NNP cord-262248-q5eijunp 82 10 therapy therapy NN cord-262248-q5eijunp 82 11 combined combine VBN cord-262248-q5eijunp 82 12 with with IN cord-262248-q5eijunp 82 13 declining decline VBG cord-262248-q5eijunp 82 14 efficacy efficacy NN cord-262248-q5eijunp 82 15 of of IN cord-262248-q5eijunp 82 16 such such JJ cord-262248-q5eijunp 82 17 drugs drug NNS cord-262248-q5eijunp 82 18 due due JJ cord-262248-q5eijunp 82 19 to to IN cord-262248-q5eijunp 82 20 widespread widespread JJ cord-262248-q5eijunp 82 21 resistance resistance NN cord-262248-q5eijunp 82 22 is be VBZ cord-262248-q5eijunp 82 23 leading lead VBG cord-262248-q5eijunp 82 24 to to IN cord-262248-q5eijunp 82 25 the the DT cord-262248-q5eijunp 82 26 development development NN cord-262248-q5eijunp 82 27 and and CC cord-262248-q5eijunp 82 28 use use NN cord-262248-q5eijunp 82 29 of of IN cord-262248-q5eijunp 82 30 rapid rapid JJ cord-262248-q5eijunp 82 31 diagnostic diagnostic JJ cord-262248-q5eijunp 82 32 tools tool NNS cord-262248-q5eijunp 82 33 that that WDT cord-262248-q5eijunp 82 34 could could MD cord-262248-q5eijunp 82 35 support support VB cord-262248-q5eijunp 82 36 the the DT cord-262248-q5eijunp 82 37 use use NN cord-262248-q5eijunp 82 38 of of IN cord-262248-q5eijunp 82 39 Ab ab NN cord-262248-q5eijunp 82 40 - - HYPH cord-262248-q5eijunp 82 41 based base VBN cord-262248-q5eijunp 82 42 therapies therapy NNS cord-262248-q5eijunp 82 43 . . . cord-262248-q5eijunp 83 1 The the DT cord-262248-q5eijunp 83 2 ongoing ongoing JJ cord-262248-q5eijunp 83 3 Ebola Ebola NNP cord-262248-q5eijunp 83 4 epidemic epidemic NN cord-262248-q5eijunp 83 5 provides provide VBZ cord-262248-q5eijunp 83 6 a a DT cord-262248-q5eijunp 83 7 special special JJ cord-262248-q5eijunp 83 8 lens lens NN cord-262248-q5eijunp 83 9 for for IN cord-262248-q5eijunp 83 10 understanding understand VBG cord-262248-q5eijunp 83 11 the the DT cord-262248-q5eijunp 83 12 promise promise NN cord-262248-q5eijunp 83 13 and and CC cord-262248-q5eijunp 83 14 roadblocks roadblock NNS cord-262248-q5eijunp 83 15 to to IN cord-262248-q5eijunp 83 16 the the DT cord-262248-q5eijunp 83 17 development development NN cord-262248-q5eijunp 83 18 of of IN cord-262248-q5eijunp 83 19 Ab ab NN cord-262248-q5eijunp 83 20 - - HYPH cord-262248-q5eijunp 83 21 based base VBN cord-262248-q5eijunp 83 22 therapies therapy NNS cord-262248-q5eijunp 83 23 for for IN cord-262248-q5eijunp 83 24 infectious infectious JJ cord-262248-q5eijunp 83 25 diseases disease NNS cord-262248-q5eijunp 83 26 , , , cord-262248-q5eijunp 83 27 as as RB cord-262248-q5eijunp 83 28 well well RB cord-262248-q5eijunp 83 29 as as IN cord-262248-q5eijunp 83 30 ethical ethical JJ cord-262248-q5eijunp 83 31 and and CC cord-262248-q5eijunp 83 32 cultural cultural JJ cord-262248-q5eijunp 83 33 considerations consideration NNS cord-262248-q5eijunp 83 34 that that WDT cord-262248-q5eijunp 83 35 pertain pertain VBP cord-262248-q5eijunp 83 36 to to IN cord-262248-q5eijunp 83 37 conducting conduct VBG cord-262248-q5eijunp 83 38 clinical clinical JJ cord-262248-q5eijunp 83 39 trials trial NNS cord-262248-q5eijunp 83 40 in in IN cord-262248-q5eijunp 83 41 the the DT cord-262248-q5eijunp 83 42 midst midst NN cord-262248-q5eijunp 83 43 of of IN cord-262248-q5eijunp 83 44 an an DT cord-262248-q5eijunp 83 45 epidemic epidemic NN cord-262248-q5eijunp 83 46 in in IN cord-262248-q5eijunp 83 47 under under IN cord-262248-q5eijunp 83 48 - - HYPH cord-262248-q5eijunp 83 49 resourced resource VBN cord-262248-q5eijunp 83 50 countries country NNS cord-262248-q5eijunp 83 51 . . . cord-262248-q5eijunp 84 1 Precedent precedent NN cord-262248-q5eijunp 84 2 for for IN cord-262248-q5eijunp 84 3 the the DT cord-262248-q5eijunp 84 4 use use NN cord-262248-q5eijunp 84 5 of of IN cord-262248-q5eijunp 84 6 convalescent convalescent NNP cord-262248-q5eijunp 84 7 sera sera NNP cord-262248-q5eijunp 84 8 during during IN cord-262248-q5eijunp 84 9 epidemics epidemic NNS cord-262248-q5eijunp 84 10 signals signal NNS cord-262248-q5eijunp 84 11 promise promise VBP cord-262248-q5eijunp 84 12 that that IN cord-262248-q5eijunp 84 13 trials trial NNS cord-262248-q5eijunp 84 14 of of IN cord-262248-q5eijunp 84 15 sera sera NNP cord-262248-q5eijunp 84 16 can can MD cord-262248-q5eijunp 84 17 be be VB cord-262248-q5eijunp 84 18 conducted conduct VBN cord-262248-q5eijunp 84 19 even even RB cord-262248-q5eijunp 84 20 as as IN cord-262248-q5eijunp 84 21 the the DT cord-262248-q5eijunp 84 22 current current JJ cord-262248-q5eijunp 84 23 Ebola Ebola NNP cord-262248-q5eijunp 84 24 epidemic epidemic NN cord-262248-q5eijunp 84 25 rages rage NNS cord-262248-q5eijunp 84 26 [ [ -LRB- cord-262248-q5eijunp 84 27 21 21 CD cord-262248-q5eijunp 84 28 ] ] -RRB- cord-262248-q5eijunp 84 29 . . . cord-262248-q5eijunp 85 1 We -PRON- PRP cord-262248-q5eijunp 85 2 note note VBP cord-262248-q5eijunp 85 3 that that IN cord-262248-q5eijunp 85 4 if if IN cord-262248-q5eijunp 85 5 a a DT cord-262248-q5eijunp 85 6 stockpile stockpile NN cord-262248-q5eijunp 85 7 of of IN cord-262248-q5eijunp 85 8 effective effective JJ cord-262248-q5eijunp 85 9 Ab Ab NNP cord-262248-q5eijunp 85 10 preparations preparation NNS cord-262248-q5eijunp 85 11 against against IN cord-262248-q5eijunp 85 12 Ebola Ebola NNP cord-262248-q5eijunp 85 13 had have VBD cord-262248-q5eijunp 85 14 been be VBN cord-262248-q5eijunp 85 15 available available JJ cord-262248-q5eijunp 85 16 early early RB cord-262248-q5eijunp 85 17 in in IN cord-262248-q5eijunp 85 18 the the DT cord-262248-q5eijunp 85 19 current current JJ cord-262248-q5eijunp 85 20 outbreak outbreak NN cord-262248-q5eijunp 85 21 , , , cord-262248-q5eijunp 85 22 the the DT cord-262248-q5eijunp 85 23 administration administration NN cord-262248-q5eijunp 85 24 of of IN cord-262248-q5eijunp 85 25 these these DT cord-262248-q5eijunp 85 26 preparations preparation NNS cord-262248-q5eijunp 85 27 to to IN cord-262248-q5eijunp 85 28 contacts contact NNS cord-262248-q5eijunp 85 29 might may MD cord-262248-q5eijunp 85 30 have have VB cord-262248-q5eijunp 85 31 provided provide VBN cord-262248-q5eijunp 85 32 them -PRON- PRP cord-262248-q5eijunp 85 33 with with IN cord-262248-q5eijunp 85 34 immediate immediate JJ cord-262248-q5eijunp 85 35 immunity immunity NN cord-262248-q5eijunp 85 36 , , , cord-262248-q5eijunp 85 37 possibly possibly RB cord-262248-q5eijunp 85 38 resulting result VBG cord-262248-q5eijunp 85 39 in in IN cord-262248-q5eijunp 85 40 early early JJ cord-262248-q5eijunp 85 41 containment containment NN cord-262248-q5eijunp 85 42 of of IN cord-262248-q5eijunp 85 43 the the DT cord-262248-q5eijunp 85 44 epidemic epidemic NN cord-262248-q5eijunp 85 45 and and CC cord-262248-q5eijunp 85 46 prevention prevention NN cord-262248-q5eijunp 85 47 of of IN cord-262248-q5eijunp 85 48 thousands thousand NNS cord-262248-q5eijunp 85 49 of of IN cord-262248-q5eijunp 85 50 deaths death NNS cord-262248-q5eijunp 85 51 . . . cord-262248-q5eijunp 86 1 The the DT cord-262248-q5eijunp 86 2 fact fact NN cord-262248-q5eijunp 86 3 that that IN cord-262248-q5eijunp 86 4 such such JJ cord-262248-q5eijunp 86 5 preparations preparation NNS cord-262248-q5eijunp 86 6 were be VBD cord-262248-q5eijunp 86 7 not not RB cord-262248-q5eijunp 86 8 available available JJ cord-262248-q5eijunp 86 9 in in IN cord-262248-q5eijunp 86 10 early early JJ cord-262248-q5eijunp 86 11 2014 2014 CD cord-262248-q5eijunp 86 12 reflects reflect VBZ cord-262248-q5eijunp 86 13 many many JJ cord-262248-q5eijunp 86 14 factors factor NNS cord-262248-q5eijunp 86 15 , , , cord-262248-q5eijunp 86 16 including include VBG cord-262248-q5eijunp 86 17 cost cost NN cord-262248-q5eijunp 86 18 , , , cord-262248-q5eijunp 86 19 uncertainty uncertainty NN cord-262248-q5eijunp 86 20 about about IN cord-262248-q5eijunp 86 21 efficacy efficacy NN cord-262248-q5eijunp 86 22 , , , cord-262248-q5eijunp 86 23 lack lack NN cord-262248-q5eijunp 86 24 of of IN cord-262248-q5eijunp 86 25 available available JJ cord-262248-q5eijunp 86 26 markets market NNS cord-262248-q5eijunp 86 27 , , , cord-262248-q5eijunp 86 28 and and CC cord-262248-q5eijunp 86 29 the the DT cord-262248-q5eijunp 86 30 erroneous erroneous JJ cord-262248-q5eijunp 86 31 assessment assessment NN cord-262248-q5eijunp 86 32 , , , cord-262248-q5eijunp 86 33 based base VBN cord-262248-q5eijunp 86 34 on on IN cord-262248-q5eijunp 86 35 prior prior JJ cord-262248-q5eijunp 86 36 epidemics epidemic NNS cord-262248-q5eijunp 86 37 , , , cord-262248-q5eijunp 86 38 that that IN cord-262248-q5eijunp 86 39 the the DT cord-262248-q5eijunp 86 40 threat threat NN cord-262248-q5eijunp 86 41 would would MD cord-262248-q5eijunp 86 42 be be VB cord-262248-q5eijunp 86 43 small small JJ cord-262248-q5eijunp 86 44 and and CC cord-262248-q5eijunp 86 45 localized localized JJ cord-262248-q5eijunp 86 46 . . . cord-262248-q5eijunp 87 1 The the DT cord-262248-q5eijunp 87 2 suggestion suggestion NN cord-262248-q5eijunp 87 3 has have VBZ cord-262248-q5eijunp 87 4 also also RB cord-262248-q5eijunp 87 5 been be VBN cord-262248-q5eijunp 87 6 made make VBN cord-262248-q5eijunp 87 7 that that IN cord-262248-q5eijunp 87 8 such such JJ cord-262248-q5eijunp 87 9 therapies therapy NNS cord-262248-q5eijunp 87 10 remain remain VBP cord-262248-q5eijunp 87 11 underdeveloped underdeveloped JJ cord-262248-q5eijunp 87 12 because because IN cord-262248-q5eijunp 87 13 they -PRON- PRP cord-262248-q5eijunp 87 14 are be VBP cord-262248-q5eijunp 87 15 unattractive unattractive JJ cord-262248-q5eijunp 87 16 to to IN cord-262248-q5eijunp 87 17 the the DT cord-262248-q5eijunp 87 18 pharmaceutical pharmaceutical JJ cord-262248-q5eijunp 87 19 industry industry NN cord-262248-q5eijunp 87 20 and and CC cord-262248-q5eijunp 87 21 to to IN cord-262248-q5eijunp 87 22 academic academic JJ cord-262248-q5eijunp 87 23 investigators investigator NNS cord-262248-q5eijunp 87 24 , , , cord-262248-q5eijunp 87 25 who who WP cord-262248-q5eijunp 87 26 may may MD cord-262248-q5eijunp 87 27 view view VB cord-262248-q5eijunp 87 28 them -PRON- PRP cord-262248-q5eijunp 87 29 as as IN cord-262248-q5eijunp 87 30 not not RB cord-262248-q5eijunp 87 31 fitting fit VBG cord-262248-q5eijunp 87 32 with with IN cord-262248-q5eijunp 87 33 the the DT cord-262248-q5eijunp 87 34 current current JJ cord-262248-q5eijunp 87 35 drug drug NN cord-262248-q5eijunp 87 36 development development NN cord-262248-q5eijunp 87 37 model model NN cord-262248-q5eijunp 87 38 or or CC cord-262248-q5eijunp 87 39 not not RB cord-262248-q5eijunp 87 40 being be VBG cord-262248-q5eijunp 87 41 cutting cut VBG cord-262248-q5eijunp 87 42 - - HYPH cord-262248-q5eijunp 87 43 edge edge NN cord-262248-q5eijunp 87 44 science science NN cord-262248-q5eijunp 87 45 , , , cord-262248-q5eijunp 87 46 respectively respectively RB cord-262248-q5eijunp 87 47 [ [ -LRB- cord-262248-q5eijunp 87 48 21 21 CD cord-262248-q5eijunp 87 49 ] ] -RRB- cord-262248-q5eijunp 87 50 . . . cord-262248-q5eijunp 88 1 However however RB cord-262248-q5eijunp 88 2 , , , cord-262248-q5eijunp 88 3 the the DT cord-262248-q5eijunp 88 4 fact fact NN cord-262248-q5eijunp 88 5 that that IN cord-262248-q5eijunp 88 6 Ab ab NN cord-262248-q5eijunp 88 7 - - HYPH cord-262248-q5eijunp 88 8 based base VBN cord-262248-q5eijunp 88 9 therapies therapy NNS cord-262248-q5eijunp 88 10 for for IN cord-262248-q5eijunp 88 11 Ebola Ebola NNP cord-262248-q5eijunp 88 12 are be VBP cord-262248-q5eijunp 88 13 now now RB cord-262248-q5eijunp 88 14 in in IN cord-262248-q5eijunp 88 15 development development NN cord-262248-q5eijunp 88 16 , , , cord-262248-q5eijunp 88 17 clinical clinical JJ cord-262248-q5eijunp 88 18 trials trial NNS cord-262248-q5eijunp 88 19 of of IN cord-262248-q5eijunp 88 20 sera sera NNP cord-262248-q5eijunp 88 21 are be VBP cord-262248-q5eijunp 88 22 being be VBG cord-262248-q5eijunp 88 23 designed design VBN cord-262248-q5eijunp 88 24 , , , cord-262248-q5eijunp 88 25 and and CC cord-262248-q5eijunp 88 26 compassionate compassionate JJ cord-262248-q5eijunp 88 27 use use NN cord-262248-q5eijunp 88 28 of of IN cord-262248-q5eijunp 88 29 these these DT cord-262248-q5eijunp 88 30 therapies therapy NNS cord-262248-q5eijunp 88 31 has have VBZ cord-262248-q5eijunp 88 32 been be VBN cord-262248-q5eijunp 88 33 employed employ VBN cord-262248-q5eijunp 88 34 in in IN cord-262248-q5eijunp 88 35 the the DT cord-262248-q5eijunp 88 36 midst midst NN cord-262248-q5eijunp 88 37 of of IN cord-262248-q5eijunp 88 38 the the DT cord-262248-q5eijunp 88 39 current current JJ cord-262248-q5eijunp 88 40 emergency emergency NN cord-262248-q5eijunp 88 41 suggests suggest VBZ cord-262248-q5eijunp 88 42 that that IN cord-262248-q5eijunp 88 43 clinically clinically RB cord-262248-q5eijunp 88 44 useful useful JJ cord-262248-q5eijunp 88 45 preparations preparation NNS cord-262248-q5eijunp 88 46 may may MD cord-262248-q5eijunp 88 47 be be VB cord-262248-q5eijunp 88 48 identified identify VBN cord-262248-q5eijunp 88 49 and and CC cord-262248-q5eijunp 88 50 available available JJ cord-262248-q5eijunp 88 51 shortly shortly RB cord-262248-q5eijunp 88 52 . . . cord-262248-q5eijunp 89 1 For for IN cord-262248-q5eijunp 89 2 the the DT cord-262248-q5eijunp 89 3 near near JJ cord-262248-q5eijunp 89 4 horizon horizon NN cord-262248-q5eijunp 89 5 , , , cord-262248-q5eijunp 89 6 it -PRON- PRP cord-262248-q5eijunp 89 7 is be VBZ cord-262248-q5eijunp 89 8 likely likely JJ cord-262248-q5eijunp 89 9 that that IN cord-262248-q5eijunp 89 10 Ab ab NN cord-262248-q5eijunp 89 11 - - HYPH cord-262248-q5eijunp 89 12 based base VBN cord-262248-q5eijunp 89 13 therapies therapy NNS cord-262248-q5eijunp 89 14 will will MD cord-262248-q5eijunp 89 15 continue continue VB cord-262248-q5eijunp 89 16 to to TO cord-262248-q5eijunp 89 17 make make VB cord-262248-q5eijunp 89 18 incremental incremental JJ cord-262248-q5eijunp 89 19 advances advance NNS cord-262248-q5eijunp 89 20 in in IN cord-262248-q5eijunp 89 21 the the DT cord-262248-q5eijunp 89 22 repertoire repertoire NN cord-262248-q5eijunp 89 23 of of IN cord-262248-q5eijunp 89 24 anti anti JJ cord-262248-q5eijunp 89 25 - - JJ cord-262248-q5eijunp 89 26 infective infective JJ cord-262248-q5eijunp 89 27 strategies strategy NNS cord-262248-q5eijunp 89 28 . . . cord-262248-q5eijunp 90 1 Such such JJ cord-262248-q5eijunp 90 2 areas area NNS cord-262248-q5eijunp 90 3 include include VBP cord-262248-q5eijunp 90 4 infectious infectious JJ cord-262248-q5eijunp 90 5 diseases disease NNS cord-262248-q5eijunp 90 6 caused cause VBN cord-262248-q5eijunp 90 7 by by IN cord-262248-q5eijunp 90 8 drug drug NN cord-262248-q5eijunp 90 9 - - HYPH cord-262248-q5eijunp 90 10 resistant resistant JJ cord-262248-q5eijunp 90 11 organisms organism NNS cord-262248-q5eijunp 90 12 for for IN cord-262248-q5eijunp 90 13 which which WDT cord-262248-q5eijunp 90 14 conventional conventional JJ cord-262248-q5eijunp 90 15 therapies therapy NNS cord-262248-q5eijunp 90 16 have have VBP cord-262248-q5eijunp 90 17 lost lose VBN cord-262248-q5eijunp 90 18 efficacy efficacy NN cord-262248-q5eijunp 90 19 and and CC cord-262248-q5eijunp 90 20 diseases disease NNS cord-262248-q5eijunp 90 21 for for IN cord-262248-q5eijunp 90 22 which which WDT cord-262248-q5eijunp 90 23 there there EX cord-262248-q5eijunp 90 24 is be VBZ cord-262248-q5eijunp 90 25 no no DT cord-262248-q5eijunp 90 26 available available JJ cord-262248-q5eijunp 90 27 therapy therapy NN cord-262248-q5eijunp 90 28 , , , cord-262248-q5eijunp 90 29 such such JJ cord-262248-q5eijunp 90 30 as as IN cord-262248-q5eijunp 90 31 Ebola Ebola NNP cord-262248-q5eijunp 90 32 . . . cord-262248-q5eijunp 91 1 For for IN cord-262248-q5eijunp 91 2 example example NN cord-262248-q5eijunp 91 3 , , , cord-262248-q5eijunp 91 4 the the DT cord-262248-q5eijunp 91 5 widespread widespread JJ cord-262248-q5eijunp 91 6 use use NN cord-262248-q5eijunp 91 7 of of IN cord-262248-q5eijunp 91 8 broad broad JJ cord-262248-q5eijunp 91 9 - - HYPH cord-262248-q5eijunp 91 10 spectrum spectrum NN cord-262248-q5eijunp 91 11 therapy therapy NN cord-262248-q5eijunp 91 12 has have VBZ cord-262248-q5eijunp 91 13 been be VBN cord-262248-q5eijunp 91 14 associated associate VBN cord-262248-q5eijunp 91 15 with with IN cord-262248-q5eijunp 91 16 an an DT cord-262248-q5eijunp 91 17 increase increase NN cord-262248-q5eijunp 91 18 in in IN cord-262248-q5eijunp 91 19 C. C. NNP cord-262248-q5eijunp 91 20 difficile difficile NN cord-262248-q5eijunp 91 21 colitis colitis NN cord-262248-q5eijunp 91 22 creating create VBG cord-262248-q5eijunp 91 23 an an DT cord-262248-q5eijunp 91 24 opportunity opportunity NN cord-262248-q5eijunp 91 25 for for IN cord-262248-q5eijunp 91 26 the the DT cord-262248-q5eijunp 91 27 development development NN cord-262248-q5eijunp 91 28 of of IN cord-262248-q5eijunp 91 29 toxin toxin NN cord-262248-q5eijunp 91 30 - - HYPH cord-262248-q5eijunp 91 31 neutralizing neutralize VBG cord-262248-q5eijunp 91 32 Ab Ab NNP cord-262248-q5eijunp 91 33 therapy therapy NN cord-262248-q5eijunp 91 34 [ [ -LRB- cord-262248-q5eijunp 91 35 22 22 CD cord-262248-q5eijunp 91 36 ] ] -RRB- cord-262248-q5eijunp 91 37 . . . cord-262248-q5eijunp 92 1 For for IN cord-262248-q5eijunp 92 2 the the DT cord-262248-q5eijunp 92 3 far far JJ cord-262248-q5eijunp 92 4 horizon horizon NN cord-262248-q5eijunp 92 5 , , , cord-262248-q5eijunp 92 6 we -PRON- PRP cord-262248-q5eijunp 92 7 are be VBP cord-262248-q5eijunp 92 8 optimistic optimistic JJ cord-262248-q5eijunp 92 9 that that IN cord-262248-q5eijunp 92 10 Ab ab NN cord-262248-q5eijunp 92 11 - - HYPH cord-262248-q5eijunp 92 12 based base VBN cord-262248-q5eijunp 92 13 therapies therapy NNS cord-262248-q5eijunp 92 14 will will MD cord-262248-q5eijunp 92 15 be be VB cord-262248-q5eijunp 92 16 widely widely RB cord-262248-q5eijunp 92 17 reintroduced reintroduce VBN cord-262248-q5eijunp 92 18 as as IN cord-262248-q5eijunp 92 19 anti anti JJ cord-262248-q5eijunp 92 20 - - JJ cord-262248-q5eijunp 92 21 infective infective JJ cord-262248-q5eijunp 92 22 agents agent NNS cord-262248-q5eijunp 92 23 given give VBN cord-262248-q5eijunp 92 24 their -PRON- PRP$ cord-262248-q5eijunp 92 25 inherent inherent JJ cord-262248-q5eijunp 92 26 advantages advantage NNS cord-262248-q5eijunp 92 27 in in IN cord-262248-q5eijunp 92 28 being be VBG cord-262248-q5eijunp 92 29 natural natural JJ cord-262248-q5eijunp 92 30 products product NNS cord-262248-q5eijunp 92 31 with with IN cord-262248-q5eijunp 92 32 low low JJ cord-262248-q5eijunp 92 33 toxicity toxicity NN cord-262248-q5eijunp 92 34 , , , cord-262248-q5eijunp 92 35 high high JJ cord-262248-q5eijunp 92 36 specificity specificity NN cord-262248-q5eijunp 92 37 , , , cord-262248-q5eijunp 92 38 and and CC cord-262248-q5eijunp 92 39 established establish VBD cord-262248-q5eijunp 92 40 efficacy efficacy NN cord-262248-q5eijunp 92 41 . . . cord-262248-q5eijunp 93 1 Continued continued JJ cord-262248-q5eijunp 93 2 technological technological JJ cord-262248-q5eijunp 93 3 advances advance NNS cord-262248-q5eijunp 93 4 in in IN cord-262248-q5eijunp 93 5 the the DT cord-262248-q5eijunp 93 6 form form NN cord-262248-q5eijunp 93 7 of of IN cord-262248-q5eijunp 93 8 more more RBR cord-262248-q5eijunp 93 9 efficient efficient JJ cord-262248-q5eijunp 93 10 production production NN cord-262248-q5eijunp 93 11 strategies strategy NNS cord-262248-q5eijunp 93 12 and and CC cord-262248-q5eijunp 93 13 alternative alternative JJ cord-262248-q5eijunp 93 14 production production NN cord-262248-q5eijunp 93 15 sources source NNS cord-262248-q5eijunp 93 16 , , , cord-262248-q5eijunp 93 17 such such JJ cord-262248-q5eijunp 93 18 as as IN cord-262248-q5eijunp 93 19 expression expression NN cord-262248-q5eijunp 93 20 in in IN cord-262248-q5eijunp 93 21 plants plant NNS cord-262248-q5eijunp 93 22 , , , cord-262248-q5eijunp 93 23 that that WDT cord-262248-q5eijunp 93 24 could could MD cord-262248-q5eijunp 93 25 lower lower VB cord-262248-q5eijunp 93 26 costs cost NNS cord-262248-q5eijunp 93 27 , , , cord-262248-q5eijunp 93 28 combined combine VBN cord-262248-q5eijunp 93 29 with with IN cord-262248-q5eijunp 93 30 new new JJ cord-262248-q5eijunp 93 31 therapeutic therapeutic JJ cord-262248-q5eijunp 93 32 needs need NNS cord-262248-q5eijunp 93 33 and and CC cord-262248-q5eijunp 93 34 better well JJR cord-262248-q5eijunp 93 35 diagnostics diagnostic NNS cord-262248-q5eijunp 93 36 , , , cord-262248-q5eijunp 93 37 will will MD cord-262248-q5eijunp 93 38 make make VB cord-262248-q5eijunp 93 39 their -PRON- PRP$ cord-262248-q5eijunp 93 40 use use VB cord-262248-q5eijunp 93 41 more more RBR cord-262248-q5eijunp 93 42 attractive attractive JJ cord-262248-q5eijunp 93 43 . . . cord-262248-q5eijunp 94 1 Return return VB cord-262248-q5eijunp 94 2 to to IN cord-262248-q5eijunp 94 3 the the DT cord-262248-q5eijunp 94 4 past past NN cord-262248-q5eijunp 94 5 : : : cord-262248-q5eijunp 94 6 the the DT cord-262248-q5eijunp 94 7 case case NN cord-262248-q5eijunp 94 8 for for IN cord-262248-q5eijunp 94 9 antibody antibody NN cord-262248-q5eijunp 94 10 - - HYPH cord-262248-q5eijunp 94 11 based base VBN cord-262248-q5eijunp 94 12 therapies therapy NNS cord-262248-q5eijunp 94 13 in in IN cord-262248-q5eijunp 94 14 infectious infectious JJ cord-262248-q5eijunp 94 15 diseases disease NNS cord-262248-q5eijunp 94 16 Update update NN cord-262248-q5eijunp 94 17 : : : cord-262248-q5eijunp 94 18 Ebola Ebola NNP cord-262248-q5eijunp 94 19 Virus Virus NNP cord-262248-q5eijunp 94 20 Disease Disease NNP cord-262248-q5eijunp 94 21 Epidemic Epidemic NNP cord-262248-q5eijunp 94 22 - - HYPH cord-262248-q5eijunp 94 23 West West NNP cord-262248-q5eijunp 94 24 Africa Africa NNP cord-262248-q5eijunp 94 25 Plant Plant NNP cord-262248-q5eijunp 94 26 - - HYPH cord-262248-q5eijunp 94 27 based base VBN cord-262248-q5eijunp 94 28 vaccines vaccine NNS cord-262248-q5eijunp 94 29 against against IN cord-262248-q5eijunp 94 30 viruses virus NNS cord-262248-q5eijunp 94 31 Hyperimmune Hyperimmune NNP cord-262248-q5eijunp 94 32 serum serum NN cord-262248-q5eijunp 94 33 from from IN cord-262248-q5eijunp 94 34 healthy healthy JJ cord-262248-q5eijunp 94 35 vaccinated vaccinated JJ cord-262248-q5eijunp 94 36 individuals individual NNS cord-262248-q5eijunp 94 37 for for IN cord-262248-q5eijunp 94 38 Ebola Ebola NNP cord-262248-q5eijunp 94 39 virus virus NN cord-262248-q5eijunp 94 40 disease disease NN cord-262248-q5eijunp 94 41 ? ? . cord-262248-q5eijunp 95 1 A a DT cord-262248-q5eijunp 95 2 new new JJ cord-262248-q5eijunp 95 3 synthesis synthesis NN cord-262248-q5eijunp 95 4 for for IN cord-262248-q5eijunp 95 5 antibody antibody NN cord-262248-q5eijunp 95 6 - - HYPH cord-262248-q5eijunp 95 7 mediated mediate VBN cord-262248-q5eijunp 95 8 immunity immunity NN cord-262248-q5eijunp 95 9 Broadly broadly RB cord-262248-q5eijunp 95 10 neutralizing neutralize VBG cord-262248-q5eijunp 95 11 anti anti JJ cord-262248-q5eijunp 95 12 - - JJ cord-262248-q5eijunp 95 13 HIV-1 hiv-1 JJ cord-262248-q5eijunp 95 14 antibodies antibody NNS cord-262248-q5eijunp 95 15 require require VBP cord-262248-q5eijunp 95 16 Fc Fc NNP cord-262248-q5eijunp 95 17 effector effector NN cord-262248-q5eijunp 95 18 functions function NNS cord-262248-q5eijunp 95 19 for for IN cord-262248-q5eijunp 95 20 in in IN cord-262248-q5eijunp 95 21 vivo vivo NN cord-262248-q5eijunp 95 22 activity activity NN cord-262248-q5eijunp 96 1 Polyfunctional Polyfunctional NNP cord-262248-q5eijunp 96 2 Fceffector Fceffector NNP cord-262248-q5eijunp 96 3 profiles profile NNS cord-262248-q5eijunp 96 4 mediated mediate VBN cord-262248-q5eijunp 96 5 by by IN cord-262248-q5eijunp 96 6 IgG IgG NNP cord-262248-q5eijunp 96 7 subclass subclass NN cord-262248-q5eijunp 96 8 selection selection NN cord-262248-q5eijunp 96 9 distinguish distinguish VBP cord-262248-q5eijunp 96 10 RV144 rv144 JJ cord-262248-q5eijunp 96 11 and and CC cord-262248-q5eijunp 96 12 VAX003 vax003 JJ cord-262248-q5eijunp 96 13 vaccines vaccine NNS cord-262248-q5eijunp 96 14 Broadly broadly RB cord-262248-q5eijunp 96 15 neutralizing neutralize VBG cord-262248-q5eijunp 96 16 antibodies antibody NNS cord-262248-q5eijunp 96 17 present present VBP cord-262248-q5eijunp 96 18 new new JJ cord-262248-q5eijunp 96 19 prospects prospect NNS cord-262248-q5eijunp 96 20 to to TO cord-262248-q5eijunp 96 21 counter counter VB cord-262248-q5eijunp 96 22 highly highly RB cord-262248-q5eijunp 96 23 antigenically antigenically RB cord-262248-q5eijunp 96 24 diverse diverse JJ cord-262248-q5eijunp 96 25 viruses virus NNS cord-262248-q5eijunp 97 1 Recognition recognition NN cord-262248-q5eijunp 97 2 determinants determinant NNS cord-262248-q5eijunp 97 3 of of IN cord-262248-q5eijunp 97 4 broadly broadly RB cord-262248-q5eijunp 97 5 neutralizing neutralize VBG cord-262248-q5eijunp 97 6 human human JJ cord-262248-q5eijunp 97 7 antibodies antibody NNS cord-262248-q5eijunp 97 8 against against IN cord-262248-q5eijunp 97 9 dengue dengue NN cord-262248-q5eijunp 97 10 viruses virus NNS cord-262248-q5eijunp 97 11 Broadly broadly RB cord-262248-q5eijunp 97 12 protective protective JJ cord-262248-q5eijunp 97 13 monoclonal monoclonal JJ cord-262248-q5eijunp 97 14 antibodies antibody NNS cord-262248-q5eijunp 97 15 against against IN cord-262248-q5eijunp 97 16 H3 H3 NNP cord-262248-q5eijunp 97 17 influenza influenza NN cord-262248-q5eijunp 97 18 viruses virus NNS cord-262248-q5eijunp 97 19 following follow VBG cord-262248-q5eijunp 97 20 sequential sequential JJ cord-262248-q5eijunp 97 21 immunization immunization NN cord-262248-q5eijunp 97 22 with with IN cord-262248-q5eijunp 97 23 different different JJ cord-262248-q5eijunp 97 24 hemagglutinins hemagglutinin NNS cord-262248-q5eijunp 97 25 First First NNP cord-262248-q5eijunp 97 26 administration administration NN cord-262248-q5eijunp 97 27 to to IN cord-262248-q5eijunp 97 28 humans human NNS cord-262248-q5eijunp 97 29 of of IN cord-262248-q5eijunp 97 30 a a DT cord-262248-q5eijunp 97 31 monoclonal monoclonal JJ cord-262248-q5eijunp 97 32 antibody antibody NN cord-262248-q5eijunp 97 33 cocktail cocktail NN cord-262248-q5eijunp 97 34 against against IN cord-262248-q5eijunp 97 35 rabies rabies NN cord-262248-q5eijunp 97 36 virus virus NN cord-262248-q5eijunp 97 37 : : : cord-262248-q5eijunp 97 38 safety safety NN cord-262248-q5eijunp 97 39 , , , cord-262248-q5eijunp 97 40 tolerability tolerability NN cord-262248-q5eijunp 97 41 , , , cord-262248-q5eijunp 97 42 and and CC cord-262248-q5eijunp 97 43 neutralizing neutralize VBG cord-262248-q5eijunp 97 44 activity activity NN cord-262248-q5eijunp 97 45 Treatment treatment NN cord-262248-q5eijunp 97 46 with with IN cord-262248-q5eijunp 97 47 monoclonal monoclonal JJ cord-262248-q5eijunp 97 48 antibodies antibody NNS cord-262248-q5eijunp 97 49 against against IN cord-262248-q5eijunp 97 50 Clostridium clostridium NN cord-262248-q5eijunp 97 51 difficile difficile NN cord-262248-q5eijunp 97 52 toxins toxin VBZ cord-262248-q5eijunp 97 53 Profile Profile NNP cord-262248-q5eijunp 97 54 and and CC cord-262248-q5eijunp 97 55 persistence persistence NN cord-262248-q5eijunp 97 56 of of IN cord-262248-q5eijunp 97 57 the the DT cord-262248-q5eijunp 97 58 virus virus NN cord-262248-q5eijunp 97 59 - - HYPH cord-262248-q5eijunp 97 60 specific specific JJ cord-262248-q5eijunp 97 61 neutralizing neutralize VBG cord-262248-q5eijunp 97 62 humoral humoral JJ cord-262248-q5eijunp 97 63 immune immune JJ cord-262248-q5eijunp 97 64 response response NN cord-262248-q5eijunp 97 65 in in IN cord-262248-q5eijunp 97 66 human human JJ cord-262248-q5eijunp 97 67 survivors survivor NNS cord-262248-q5eijunp 97 68 of of IN cord-262248-q5eijunp 97 69 Sudan Sudan NNP cord-262248-q5eijunp 97 70 ebolavirus ebolavirus NN cord-262248-q5eijunp 97 71 ( ( -LRB- cord-262248-q5eijunp 97 72 Gulu Gulu NNP cord-262248-q5eijunp 97 73 ) ) -RRB- cord-262248-q5eijunp 97 74 Serologic Serologic NNP cord-262248-q5eijunp 97 75 cross cross NN cord-262248-q5eijunp 97 76 - - NN cord-262248-q5eijunp 97 77 reactivity reactivity NN cord-262248-q5eijunp 97 78 of of IN cord-262248-q5eijunp 97 79 human human JJ cord-262248-q5eijunp 97 80 IgM IgM NNP cord-262248-q5eijunp 97 81 and and CC cord-262248-q5eijunp 97 82 IgG IgG NNP cord-262248-q5eijunp 97 83 antibodies antibody NNS cord-262248-q5eijunp 97 84 to to IN cord-262248-q5eijunp 97 85 five five CD cord-262248-q5eijunp 97 86 species specie NNS cord-262248-q5eijunp 97 87 of of IN cord-262248-q5eijunp 97 88 Ebola Ebola NNP cord-262248-q5eijunp 97 89 virus virus NN cord-262248-q5eijunp 97 90 Perspective perspective NN cord-262248-q5eijunp 97 91 : : : cord-262248-q5eijunp 98 1 Hypothesis hypothesis NN cord-262248-q5eijunp 98 2 : : : cord-262248-q5eijunp 99 1 serum serum NNP cord-262248-q5eijunp 99 2 IgG IgG NNP cord-262248-q5eijunp 99 3 antibody antibody NN cord-262248-q5eijunp 99 4 is be VBZ cord-262248-q5eijunp 99 5 sufficient sufficient JJ cord-262248-q5eijunp 99 6 to to TO cord-262248-q5eijunp 99 7 confer confer VB cord-262248-q5eijunp 99 8 protection protection NN cord-262248-q5eijunp 99 9 against against IN cord-262248-q5eijunp 99 10 infectious infectious JJ cord-262248-q5eijunp 99 11 diseases disease NNS cord-262248-q5eijunp 99 12 by by IN cord-262248-q5eijunp 99 13 inactivating inactivate VBG cord-262248-q5eijunp 99 14 the the DT cord-262248-q5eijunp 99 15 inoculum inoculum NN cord-262248-q5eijunp 99 16 Antibody antibody NN cord-262248-q5eijunp 99 17 - - HYPH cord-262248-q5eijunp 99 18 mediated mediate VBN cord-262248-q5eijunp 99 19 regulation regulation NN cord-262248-q5eijunp 99 20 of of IN cord-262248-q5eijunp 99 21 cellular cellular JJ cord-262248-q5eijunp 99 22 immunity immunity NN cord-262248-q5eijunp 99 23 and and CC cord-262248-q5eijunp 99 24 the the DT cord-262248-q5eijunp 99 25 inflammatory inflammatory JJ cord-262248-q5eijunp 99 26 response response NN cord-262248-q5eijunp 99 27 Development Development NNP cord-262248-q5eijunp 99 28 and and CC cord-262248-q5eijunp 99 29 characterization characterization NN cord-262248-q5eijunp 99 30 of of IN cord-262248-q5eijunp 99 31 a a DT cord-262248-q5eijunp 99 32 severe severe JJ cord-262248-q5eijunp 99 33 acute acute JJ cord-262248-q5eijunp 99 34 respiratory respiratory JJ cord-262248-q5eijunp 99 35 syndrome syndrome NN cord-262248-q5eijunp 99 36 - - HYPH cord-262248-q5eijunp 99 37 associated associate VBN cord-262248-q5eijunp 99 38 coronavirusneutralizing coronavirusneutralize VBG cord-262248-q5eijunp 99 39 human human JJ cord-262248-q5eijunp 99 40 monoclonal monoclonal JJ cord-262248-q5eijunp 99 41 antibody antibody NN cord-262248-q5eijunp 99 42 that that WDT cord-262248-q5eijunp 99 43 provides provide VBZ cord-262248-q5eijunp 99 44 effective effective JJ cord-262248-q5eijunp 99 45 immunoprophylaxis immunoprophylaxis NN cord-262248-q5eijunp 99 46 in in IN cord-262248-q5eijunp 99 47 mice mouse NNS cord-262248-q5eijunp 100 1 Hark hark VB cord-262248-q5eijunp 100 2 back back RB cord-262248-q5eijunp 100 3 : : : cord-262248-q5eijunp 100 4 passive passive JJ cord-262248-q5eijunp 100 5 immunotherapy immunotherapy NN cord-262248-q5eijunp 100 6 for for IN cord-262248-q5eijunp 100 7 influenza influenza NN cord-262248-q5eijunp 100 8 and and CC cord-262248-q5eijunp 100 9 other other JJ cord-262248-q5eijunp 100 10 serious serious JJ cord-262248-q5eijunp 100 11 infections infection NNS cord-262248-q5eijunp 100 12 Treatment Treatment NNP cord-262248-q5eijunp 100 13 of of IN cord-262248-q5eijunp 100 14 Ebola Ebola NNP cord-262248-q5eijunp 100 15 hemorrhagic hemorrhagic JJ cord-262248-q5eijunp 100 16 fever fever NN cord-262248-q5eijunp 100 17 with with IN cord-262248-q5eijunp 100 18 blood blood NN cord-262248-q5eijunp 100 19 transfusions transfusion NNS cord-262248-q5eijunp 100 20 from from IN cord-262248-q5eijunp 100 21 convalescent convalescent JJ cord-262248-q5eijunp 100 22 patients patient NNS cord-262248-q5eijunp 100 23 . . . cord-262248-q5eijunp 101 1 International International NNP cord-262248-q5eijunp 101 2 Scientific Scientific NNP cord-262248-q5eijunp 101 3 and and CC cord-262248-q5eijunp 101 4 Technical Technical NNP cord-262248-q5eijunp 101 5 Committee Committee NNP cord-262248-q5eijunp 101 6 A A NNP cord-262248-q5eijunp 101 7 Practical Practical NNP cord-262248-q5eijunp 101 8 Treatment Treatment NNP cord-262248-q5eijunp 101 9 for for IN cord-262248-q5eijunp 101 10 Patients patient NNS cord-262248-q5eijunp 102 1 With with IN cord-262248-q5eijunp 102 2 Ebola Ebola NNP cord-262248-q5eijunp 102 3 Virus Virus NNP cord-262248-q5eijunp 102 4 Disease Disease NNP cord-262248-q5eijunp 102 5 Ebola Ebola NNP cord-262248-q5eijunp 102 6 raises raise VBZ cord-262248-q5eijunp 102 7 profile profile NN cord-262248-q5eijunp 102 8 of of IN cord-262248-q5eijunp 102 9 blood blood NN cord-262248-q5eijunp 102 10 - - HYPH cord-262248-q5eijunp 102 11 based base VBN cord-262248-q5eijunp 102 12 therapy therapy NN cord-262248-q5eijunp 102 13 Which which WDT cord-262248-q5eijunp 102 14 are be VBP cord-262248-q5eijunp 102 15 the the DT cord-262248-q5eijunp 102 16 antibodies antibody NNS cord-262248-q5eijunp 102 17 to to TO cord-262248-q5eijunp 102 18 watch watch VB cord-262248-q5eijunp 102 19 in in IN