id sid tid token lemma pos cord-268388-kkhuzf3p 1 1 key key NN cord-268388-kkhuzf3p 1 2 : : : cord-268388-kkhuzf3p 2 1 cord-268388-kkhuzf3p cord-268388-kkhuzf3p JJ cord-268388-kkhuzf3p 2 2 authors author NNS cord-268388-kkhuzf3p 2 3 : : : cord-268388-kkhuzf3p 2 4 Sharif Sharif NNP cord-268388-kkhuzf3p 2 5 - - HYPH cord-268388-kkhuzf3p 2 6 Yakan Yakan NNP cord-268388-kkhuzf3p 2 7 , , , cord-268388-kkhuzf3p 2 8 Ahmad Ahmad NNP cord-268388-kkhuzf3p 2 9 ; ; : cord-268388-kkhuzf3p 2 10 Kanj Kanj NNP cord-268388-kkhuzf3p 2 11 , , , cord-268388-kkhuzf3p 2 12 Souha Souha NNP cord-268388-kkhuzf3p 2 13 S. S. NNP cord-268388-kkhuzf3p 2 14 title title NN cord-268388-kkhuzf3p 2 15 : : : cord-268388-kkhuzf3p 2 16 Emergence emergence NN cord-268388-kkhuzf3p 2 17 of of IN cord-268388-kkhuzf3p 2 18 MERS MERS NNP cord-268388-kkhuzf3p 2 19 - - HYPH cord-268388-kkhuzf3p 2 20 CoV CoV NNP cord-268388-kkhuzf3p 2 21 in in IN cord-268388-kkhuzf3p 2 22 the the DT cord-268388-kkhuzf3p 2 23 Middle Middle NNP cord-268388-kkhuzf3p 2 24 East East NNP cord-268388-kkhuzf3p 2 25 : : : cord-268388-kkhuzf3p 2 26 Origins Origins NNP cord-268388-kkhuzf3p 2 27 , , , cord-268388-kkhuzf3p 2 28 Transmission Transmission NNP cord-268388-kkhuzf3p 2 29 , , , cord-268388-kkhuzf3p 2 30 Treatment Treatment NNP cord-268388-kkhuzf3p 2 31 , , , cord-268388-kkhuzf3p 2 32 and and CC cord-268388-kkhuzf3p 2 33 Perspectives perspective NNS cord-268388-kkhuzf3p 3 1 date date NN cord-268388-kkhuzf3p 3 2 : : : cord-268388-kkhuzf3p 3 3 2014 2014 CD cord-268388-kkhuzf3p 3 4 - - SYM cord-268388-kkhuzf3p 3 5 12 12 CD cord-268388-kkhuzf3p 3 6 - - HYPH cord-268388-kkhuzf3p 3 7 04 04 CD cord-268388-kkhuzf3p 3 8 journal journal NN cord-268388-kkhuzf3p 3 9 : : : cord-268388-kkhuzf3p 4 1 PLoS PLoS NNP cord-268388-kkhuzf3p 4 2 Pathog Pathog NNP cord-268388-kkhuzf3p 4 3 DOI DOI NNP cord-268388-kkhuzf3p 4 4 : : : cord-268388-kkhuzf3p 4 5 10.1371 10.1371 CD cord-268388-kkhuzf3p 4 6 / / SYM cord-268388-kkhuzf3p 4 7 journal.ppat.1004457 journal.ppat.1004457 NN cord-268388-kkhuzf3p 4 8 sha sha NNP cord-268388-kkhuzf3p 4 9 : : : cord-268388-kkhuzf3p 5 1 450b87fb527fca46dfc933e35d4de041bf170bd9 450b87fb527fca46dfc933e35d4de041bf170bd9 CD cord-268388-kkhuzf3p 5 2 doc_id doc_id CD cord-268388-kkhuzf3p 5 3 : : : cord-268388-kkhuzf3p 5 4 268388 268388 CD cord-268388-kkhuzf3p 5 5 cord_uid cord_uid NNS cord-268388-kkhuzf3p 5 6 : : : cord-268388-kkhuzf3p 6 1 kkhuzf3p kkhuzf3p NNP cord-268388-kkhuzf3p 7 1 nan nan NNP cord-268388-kkhuzf3p 7 2 Two two CD cord-268388-kkhuzf3p 7 3 years year NNS cord-268388-kkhuzf3p 7 4 have have VBP cord-268388-kkhuzf3p 7 5 passed pass VBN cord-268388-kkhuzf3p 7 6 since since IN cord-268388-kkhuzf3p 7 7 the the DT cord-268388-kkhuzf3p 7 8 initial initial JJ cord-268388-kkhuzf3p 7 9 description description NN cord-268388-kkhuzf3p 7 10 of of IN cord-268388-kkhuzf3p 7 11 the the DT cord-268388-kkhuzf3p 7 12 Middle Middle NNP cord-268388-kkhuzf3p 7 13 East East NNP cord-268388-kkhuzf3p 7 14 respiratory respiratory JJ cord-268388-kkhuzf3p 7 15 syndrome syndrome NN cord-268388-kkhuzf3p 7 16 coronavirus coronavirus NN cord-268388-kkhuzf3p 7 17 ( ( -LRB- cord-268388-kkhuzf3p 7 18 MERS MERS NNP cord-268388-kkhuzf3p 7 19 - - HYPH cord-268388-kkhuzf3p 7 20 CoV CoV NNP cord-268388-kkhuzf3p 7 21 ) ) -RRB- cord-268388-kkhuzf3p 7 22 , , , cord-268388-kkhuzf3p 7 23 yet yet CC cord-268388-kkhuzf3p 7 24 the the DT cord-268388-kkhuzf3p 7 25 epidemic epidemic NN cord-268388-kkhuzf3p 7 26 is be VBZ cord-268388-kkhuzf3p 7 27 far far RB cord-268388-kkhuzf3p 7 28 from from IN cord-268388-kkhuzf3p 7 29 being be VBG cord-268388-kkhuzf3p 7 30 controlled control VBN cord-268388-kkhuzf3p 7 31 . . . cord-268388-kkhuzf3p 8 1 The the DT cord-268388-kkhuzf3p 8 2 high high JJ cord-268388-kkhuzf3p 8 3 case case NN cord-268388-kkhuzf3p 8 4 fatality fatality NN cord-268388-kkhuzf3p 8 5 rate rate NN cord-268388-kkhuzf3p 8 6 , , , cord-268388-kkhuzf3p 8 7 the the DT cord-268388-kkhuzf3p 8 8 recent recent JJ cord-268388-kkhuzf3p 8 9 steep steep JJ cord-268388-kkhuzf3p 8 10 increase increase NN cord-268388-kkhuzf3p 8 11 in in IN cord-268388-kkhuzf3p 8 12 reported report VBN cord-268388-kkhuzf3p 8 13 cases case NNS cord-268388-kkhuzf3p 8 14 , , , cord-268388-kkhuzf3p 8 15 and and CC cord-268388-kkhuzf3p 8 16 the the DT cord-268388-kkhuzf3p 8 17 potential potential NN cord-268388-kkhuzf3p 8 18 to to TO cord-268388-kkhuzf3p 8 19 cause cause VB cord-268388-kkhuzf3p 8 20 a a DT cord-268388-kkhuzf3p 8 21 global global JJ cord-268388-kkhuzf3p 8 22 pandemic pandemic NN cord-268388-kkhuzf3p 8 23 during during IN cord-268388-kkhuzf3p 8 24 the the DT cord-268388-kkhuzf3p 8 25 upcoming upcoming JJ cord-268388-kkhuzf3p 8 26 Hajj Hajj NNP cord-268388-kkhuzf3p 8 27 season season NN cord-268388-kkhuzf3p 8 28 are be VBP cord-268388-kkhuzf3p 8 29 serious serious JJ cord-268388-kkhuzf3p 8 30 concerns concern NNS cord-268388-kkhuzf3p 8 31 . . . cord-268388-kkhuzf3p 9 1 Although although IN cord-268388-kkhuzf3p 9 2 a a DT cord-268388-kkhuzf3p 9 3 wealth wealth NN cord-268388-kkhuzf3p 9 4 of of IN cord-268388-kkhuzf3p 9 5 information information NN cord-268388-kkhuzf3p 9 6 about about IN cord-268388-kkhuzf3p 9 7 the the DT cord-268388-kkhuzf3p 9 8 pathophysiology pathophysiology NN cord-268388-kkhuzf3p 9 9 , , , cord-268388-kkhuzf3p 9 10 proposed propose VBN cord-268388-kkhuzf3p 9 11 animal animal NN cord-268388-kkhuzf3p 9 12 reservoir reservoir NN cord-268388-kkhuzf3p 9 13 , , , cord-268388-kkhuzf3p 9 14 and and CC cord-268388-kkhuzf3p 9 15 intermediate intermediate JJ cord-268388-kkhuzf3p 9 16 host host NN cord-268388-kkhuzf3p 9 17 has have VBZ cord-268388-kkhuzf3p 9 18 been be VBN cord-268388-kkhuzf3p 9 19 revealed reveal VBN cord-268388-kkhuzf3p 9 20 , , , cord-268388-kkhuzf3p 9 21 many many JJ cord-268388-kkhuzf3p 9 22 questions question NNS cord-268388-kkhuzf3p 9 23 remain remain VBP cord-268388-kkhuzf3p 9 24 unanswered unanswered JJ cord-268388-kkhuzf3p 9 25 . . . cord-268388-kkhuzf3p 10 1 We -PRON- PRP cord-268388-kkhuzf3p 10 2 herein herein RB cord-268388-kkhuzf3p 10 3 review review VBP cord-268388-kkhuzf3p 10 4 MERS MERS NNP cord-268388-kkhuzf3p 10 5 - - HYPH cord-268388-kkhuzf3p 10 6 CoV CoV NNP cord-268388-kkhuzf3p 10 7 , , , cord-268388-kkhuzf3p 10 8 covering cover VBG cord-268388-kkhuzf3p 10 9 its -PRON- PRP$ cord-268388-kkhuzf3p 10 10 proposed propose VBN cord-268388-kkhuzf3p 10 11 origins origin NNS cord-268388-kkhuzf3p 10 12 , , , cord-268388-kkhuzf3p 10 13 route route NN cord-268388-kkhuzf3p 10 14 of of IN cord-268388-kkhuzf3p 10 15 transmission transmission NN cord-268388-kkhuzf3p 10 16 , , , cord-268388-kkhuzf3p 10 17 treatment treatment NN cord-268388-kkhuzf3p 10 18 options option NNS cord-268388-kkhuzf3p 10 19 , , , cord-268388-kkhuzf3p 10 20 and and CC cord-268388-kkhuzf3p 10 21 future future JJ cord-268388-kkhuzf3p 10 22 perspectives perspective NNS cord-268388-kkhuzf3p 10 23 . . . cord-268388-kkhuzf3p 11 1 First first RB cord-268388-kkhuzf3p 11 2 reported report VBN cord-268388-kkhuzf3p 11 3 in in IN cord-268388-kkhuzf3p 11 4 2012 2012 CD cord-268388-kkhuzf3p 11 5 [ [ -LRB- cord-268388-kkhuzf3p 11 6 1 1 CD cord-268388-kkhuzf3p 11 7 ] ] -RRB- cord-268388-kkhuzf3p 11 8 , , , cord-268388-kkhuzf3p 11 9 Middle Middle NNP cord-268388-kkhuzf3p 11 10 East East NNP cord-268388-kkhuzf3p 11 11 respiratory respiratory JJ cord-268388-kkhuzf3p 11 12 syndrome syndrome NN cord-268388-kkhuzf3p 11 13 coronavirus coronavirus NN cord-268388-kkhuzf3p 11 14 ( ( -LRB- cord-268388-kkhuzf3p 11 15 MERS MERS NNP cord-268388-kkhuzf3p 11 16 - - HYPH cord-268388-kkhuzf3p 11 17 CoV CoV NNP cord-268388-kkhuzf3p 11 18 ) ) -RRB- cord-268388-kkhuzf3p 11 19 is be VBZ cord-268388-kkhuzf3p 11 20 a a DT cord-268388-kkhuzf3p 11 21 novel novel JJ cord-268388-kkhuzf3p 11 22 coronavirus coronavirus NN cord-268388-kkhuzf3p 11 23 and and CC cord-268388-kkhuzf3p 11 24 the the DT cord-268388-kkhuzf3p 11 25 first first JJ cord-268388-kkhuzf3p 11 26 lineage lineage NN cord-268388-kkhuzf3p 11 27 2C 2c NN cord-268388-kkhuzf3p 11 28 Betacoronavirus Betacoronavirus NNP cord-268388-kkhuzf3p 11 29 known know VBD cord-268388-kkhuzf3p 11 30 to to TO cord-268388-kkhuzf3p 11 31 infect infect VB cord-268388-kkhuzf3p 11 32 humans human NNS cord-268388-kkhuzf3p 11 33 [ [ -LRB- cord-268388-kkhuzf3p 11 34 2 2 CD cord-268388-kkhuzf3p 11 35 ] ] -RRB- cord-268388-kkhuzf3p 11 36 . . . cord-268388-kkhuzf3p 12 1 With with IN cord-268388-kkhuzf3p 12 2 a a DT cord-268388-kkhuzf3p 12 3 case case NN cord-268388-kkhuzf3p 12 4 fatality fatality NN cord-268388-kkhuzf3p 12 5 rate rate NN cord-268388-kkhuzf3p 12 6 of of IN cord-268388-kkhuzf3p 12 7 35 35 CD cord-268388-kkhuzf3p 12 8 % % NN cord-268388-kkhuzf3p 12 9 , , , cord-268388-kkhuzf3p 12 10 an an DT cord-268388-kkhuzf3p 12 11 urgent urgent JJ cord-268388-kkhuzf3p 12 12 response response NN cord-268388-kkhuzf3p 12 13 is be VBZ cord-268388-kkhuzf3p 12 14 needed need VBN cord-268388-kkhuzf3p 12 15 to to TO cord-268388-kkhuzf3p 12 16 prevent prevent VB cord-268388-kkhuzf3p 12 17 a a DT cord-268388-kkhuzf3p 12 18 global global JJ cord-268388-kkhuzf3p 12 19 pandemic pandemic NN cord-268388-kkhuzf3p 12 20 [ [ -LRB- cord-268388-kkhuzf3p 12 21 3 3 CD cord-268388-kkhuzf3p 12 22 ] ] -RRB- cord-268388-kkhuzf3p 12 23 . . . cord-268388-kkhuzf3p 13 1 Prior prior RB cord-268388-kkhuzf3p 13 2 to to IN cord-268388-kkhuzf3p 13 3 2003 2003 CD cord-268388-kkhuzf3p 13 4 , , , cord-268388-kkhuzf3p 13 5 coronaviruses coronaviruse NNS cord-268388-kkhuzf3p 13 6 were be VBD cord-268388-kkhuzf3p 13 7 not not RB cord-268388-kkhuzf3p 13 8 considered consider VBN cord-268388-kkhuzf3p 13 9 serious serious JJ cord-268388-kkhuzf3p 13 10 human human JJ cord-268388-kkhuzf3p 13 11 pathogens pathogen NNS cord-268388-kkhuzf3p 13 12 since since IN cord-268388-kkhuzf3p 13 13 they -PRON- PRP cord-268388-kkhuzf3p 13 14 only only RB cord-268388-kkhuzf3p 13 15 caused cause VBD cord-268388-kkhuzf3p 13 16 mild mild JJ cord-268388-kkhuzf3p 13 17 upper upper JJ cord-268388-kkhuzf3p 13 18 respiratory respiratory JJ cord-268388-kkhuzf3p 13 19 tract tract NN cord-268388-kkhuzf3p 13 20 infections infection NNS cord-268388-kkhuzf3p 13 21 ( ( -LRB- cord-268388-kkhuzf3p 13 22 URTIs urtis VBP cord-268388-kkhuzf3p 13 23 ) ) -RRB- cord-268388-kkhuzf3p 13 24 [ [ -LRB- cord-268388-kkhuzf3p 13 25 4 4 CD cord-268388-kkhuzf3p 13 26 ] ] -RRB- cord-268388-kkhuzf3p 13 27 . . . cord-268388-kkhuzf3p 14 1 The the DT cord-268388-kkhuzf3p 14 2 first first JJ cord-268388-kkhuzf3p 14 3 zoonotic zoonotic JJ cord-268388-kkhuzf3p 14 4 introduction introduction NN cord-268388-kkhuzf3p 14 5 of of IN cord-268388-kkhuzf3p 14 6 a a DT cord-268388-kkhuzf3p 14 7 coronavirus coronavirus NN cord-268388-kkhuzf3p 14 8 into into IN cord-268388-kkhuzf3p 14 9 the the DT cord-268388-kkhuzf3p 14 10 human human JJ cord-268388-kkhuzf3p 14 11 population population NN cord-268388-kkhuzf3p 14 12 occurred occur VBD cord-268388-kkhuzf3p 14 13 with with IN cord-268388-kkhuzf3p 14 14 the the DT cord-268388-kkhuzf3p 14 15 severe severe JJ cord-268388-kkhuzf3p 14 16 acute acute JJ cord-268388-kkhuzf3p 14 17 respiratory respiratory JJ cord-268388-kkhuzf3p 14 18 syndrome syndrome NN cord-268388-kkhuzf3p 14 19 coronavirus coronavirus NN cord-268388-kkhuzf3p 14 20 ( ( -LRB- cord-268388-kkhuzf3p 14 21 SARS SARS NNP cord-268388-kkhuzf3p 14 22 - - HYPH cord-268388-kkhuzf3p 14 23 CoV CoV NNP cord-268388-kkhuzf3p 14 24 ) ) -RRB- cord-268388-kkhuzf3p 14 25 in in IN cord-268388-kkhuzf3p 14 26 2002 2002 CD cord-268388-kkhuzf3p 14 27 . . . cord-268388-kkhuzf3p 15 1 SARS SARS NNP cord-268388-kkhuzf3p 15 2 - - HYPH cord-268388-kkhuzf3p 15 3 CoV CoV NNP cord-268388-kkhuzf3p 15 4 caused cause VBD cord-268388-kkhuzf3p 15 5 a a DT cord-268388-kkhuzf3p 15 6 global global JJ cord-268388-kkhuzf3p 15 7 pandemic pandemic NN cord-268388-kkhuzf3p 15 8 , , , cord-268388-kkhuzf3p 15 9 with with IN cord-268388-kkhuzf3p 15 10 8,400 8,400 CD cord-268388-kkhuzf3p 15 11 recorded record VBN cord-268388-kkhuzf3p 15 12 cases case NNS cord-268388-kkhuzf3p 15 13 and and CC cord-268388-kkhuzf3p 15 14 800 800 CD cord-268388-kkhuzf3p 15 15 deaths death NNS cord-268388-kkhuzf3p 15 16 [ [ -LRB- cord-268388-kkhuzf3p 15 17 5 5 CD cord-268388-kkhuzf3p 15 18 ] ] -RRB- cord-268388-kkhuzf3p 15 19 . . . cord-268388-kkhuzf3p 16 1 MERS MERS NNP cord-268388-kkhuzf3p 16 2 - - HYPH cord-268388-kkhuzf3p 16 3 CoV CoV NNP cord-268388-kkhuzf3p 16 4 marks mark VBZ cord-268388-kkhuzf3p 16 5 the the DT cord-268388-kkhuzf3p 16 6 second second RB cord-268388-kkhuzf3p 16 7 known know VBN cord-268388-kkhuzf3p 16 8 zoonotic zoonotic JJ cord-268388-kkhuzf3p 16 9 introduction introduction NN cord-268388-kkhuzf3p 16 10 of of IN cord-268388-kkhuzf3p 16 11 a a DT cord-268388-kkhuzf3p 16 12 highly highly RB cord-268388-kkhuzf3p 16 13 pathogenic pathogenic JJ cord-268388-kkhuzf3p 16 14 coronavirus coronavirus NN cord-268388-kkhuzf3p 16 15 , , , cord-268388-kkhuzf3p 16 16 probably probably RB cord-268388-kkhuzf3p 16 17 originating originate VBG cord-268388-kkhuzf3p 16 18 from from IN cord-268388-kkhuzf3p 16 19 bats bat NNS cord-268388-kkhuzf3p 16 20 . . . cord-268388-kkhuzf3p 17 1 Three three CD cord-268388-kkhuzf3p 17 2 lines line NNS cord-268388-kkhuzf3p 17 3 of of IN cord-268388-kkhuzf3p 17 4 evidence evidence NN cord-268388-kkhuzf3p 17 5 currently currently RB cord-268388-kkhuzf3p 17 6 support support VBP cord-268388-kkhuzf3p 17 7 this this DT cord-268388-kkhuzf3p 17 8 theory theory NN cord-268388-kkhuzf3p 17 9 : : : cord-268388-kkhuzf3p 17 10 ( ( -LRB- cord-268388-kkhuzf3p 17 11 1 1 LS cord-268388-kkhuzf3p 17 12 ) ) -RRB- cord-268388-kkhuzf3p 17 13 the the DT cord-268388-kkhuzf3p 17 14 very very RB cord-268388-kkhuzf3p 17 15 close close JJ cord-268388-kkhuzf3p 17 16 phylogenetic phylogenetic JJ cord-268388-kkhuzf3p 17 17 similarity similarity NN cord-268388-kkhuzf3p 17 18 with with IN cord-268388-kkhuzf3p 17 19 the the DT cord-268388-kkhuzf3p 17 20 bat bat NN cord-268388-kkhuzf3p 17 21 Betacoronaviruses Betacoronaviruses NNP cord-268388-kkhuzf3p 17 22 : : : cord-268388-kkhuzf3p 17 23 BtCoV BtCoV NNP cord-268388-kkhuzf3p 17 24 - - HYPH cord-268388-kkhuzf3p 17 25 HKU4 HKU4 NNP cord-268388-kkhuzf3p 17 26 and and CC cord-268388-kkhuzf3p 17 27 BtCoV BtCoV NNP cord-268388-kkhuzf3p 17 28 - - HYPH cord-268388-kkhuzf3p 17 29 HKU5 HKU5 NNP cord-268388-kkhuzf3p 17 30 [ [ -LRB- cord-268388-kkhuzf3p 17 31 6 6 CD cord-268388-kkhuzf3p 17 32 ] ] -RRB- cord-268388-kkhuzf3p 17 33 ; ; : cord-268388-kkhuzf3p 17 34 ( ( -LRB- cord-268388-kkhuzf3p 17 35 2 2 LS cord-268388-kkhuzf3p 17 36 ) ) -RRB- cord-268388-kkhuzf3p 17 37 closely closely RB cord-268388-kkhuzf3p 17 38 related related JJ cord-268388-kkhuzf3p 17 39 coronavirus coronavirus NN cord-268388-kkhuzf3p 17 40 sequences sequence NNS cord-268388-kkhuzf3p 17 41 have have VBP cord-268388-kkhuzf3p 17 42 been be VBN cord-268388-kkhuzf3p 17 43 recovered recover VBN cord-268388-kkhuzf3p 17 44 from from IN cord-268388-kkhuzf3p 17 45 bats bat NNS cord-268388-kkhuzf3p 17 46 in in IN cord-268388-kkhuzf3p 17 47 Africa Africa NNP cord-268388-kkhuzf3p 17 48 , , , cord-268388-kkhuzf3p 17 49 Asia Asia NNP cord-268388-kkhuzf3p 17 50 , , , cord-268388-kkhuzf3p 17 51 the the DT cord-268388-kkhuzf3p 17 52 Americas Americas NNPS cord-268388-kkhuzf3p 17 53 , , , cord-268388-kkhuzf3p 17 54 and and CC cord-268388-kkhuzf3p 17 55 Eurasia Eurasia NNP cord-268388-kkhuzf3p 17 56 ; ; : cord-268388-kkhuzf3p 17 57 and and CC cord-268388-kkhuzf3p 17 58 ( ( -LRB- cord-268388-kkhuzf3p 17 59 3 3 LS cord-268388-kkhuzf3p 17 60 ) ) -RRB- cord-268388-kkhuzf3p 17 61 MERS MERS NNP cord-268388-kkhuzf3p 17 62 - - HYPH cord-268388-kkhuzf3p 17 63 CoV CoV NNP cord-268388-kkhuzf3p 17 64 uses use VBZ cord-268388-kkhuzf3p 17 65 the the DT cord-268388-kkhuzf3p 17 66 evolutionary evolutionary JJ cord-268388-kkhuzf3p 17 67 conserved conserve VBN cord-268388-kkhuzf3p 17 68 dipeptidyl dipeptidyl JJ cord-268388-kkhuzf3p 17 69 peptidase-4 peptidase-4 NNP cord-268388-kkhuzf3p 17 70 ( ( -LRB- cord-268388-kkhuzf3p 17 71 DPP4 DPP4 NNP cord-268388-kkhuzf3p 17 72 ) ) -RRB- cord-268388-kkhuzf3p 17 73 protein protein NN cord-268388-kkhuzf3p 17 74 in in IN cord-268388-kkhuzf3p 17 75 Pipistrellus Pipistrellus NNP cord-268388-kkhuzf3p 17 76 pipistrellus pipistrellus NN cord-268388-kkhuzf3p 17 77 bats bat NNS cord-268388-kkhuzf3p 17 78 for for IN cord-268388-kkhuzf3p 17 79 cell cell NN cord-268388-kkhuzf3p 17 80 entry entry NN cord-268388-kkhuzf3p 17 81 [ [ -LRB- cord-268388-kkhuzf3p 17 82 7 7 CD cord-268388-kkhuzf3p 17 83 ] ] -RRB- cord-268388-kkhuzf3p 17 84 . . . cord-268388-kkhuzf3p 18 1 Since since IN cord-268388-kkhuzf3p 18 2 human human JJ cord-268388-kkhuzf3p 18 3 - - HYPH cord-268388-kkhuzf3p 18 4 bat bat NN cord-268388-kkhuzf3p 18 5 contact contact NN cord-268388-kkhuzf3p 18 6 is be VBZ cord-268388-kkhuzf3p 18 7 limited limit VBN cord-268388-kkhuzf3p 18 8 , , , cord-268388-kkhuzf3p 18 9 camels camel NNS cord-268388-kkhuzf3p 18 10 have have VBP cord-268388-kkhuzf3p 18 11 been be VBN cord-268388-kkhuzf3p 18 12 implicated implicate VBN cord-268388-kkhuzf3p 18 13 as as IN cord-268388-kkhuzf3p 18 14 probable probable JJ cord-268388-kkhuzf3p 18 15 intermediate intermediate JJ cord-268388-kkhuzf3p 18 16 hosts host NNS cord-268388-kkhuzf3p 18 17 . . . cord-268388-kkhuzf3p 19 1 MERS MERS NNP cord-268388-kkhuzf3p 19 2 - - HYPH cord-268388-kkhuzf3p 19 3 CoV CoV NNP cord-268388-kkhuzf3p 19 4 appears appear VBZ cord-268388-kkhuzf3p 19 5 to to TO cord-268388-kkhuzf3p 19 6 have have VB cord-268388-kkhuzf3p 19 7 been be VBN cord-268388-kkhuzf3p 19 8 circulating circulate VBG cord-268388-kkhuzf3p 19 9 in in IN cord-268388-kkhuzf3p 19 10 dromedary dromedary NN cord-268388-kkhuzf3p 19 11 camels camel NNS cord-268388-kkhuzf3p 19 12 for for IN cord-268388-kkhuzf3p 19 13 over over IN cord-268388-kkhuzf3p 19 14 20 20 CD cord-268388-kkhuzf3p 19 15 years year NNS cord-268388-kkhuzf3p 19 16 [ [ -LRB- cord-268388-kkhuzf3p 19 17 8 8 CD cord-268388-kkhuzf3p 19 18 ] ] -RRB- cord-268388-kkhuzf3p 19 19 . . . cord-268388-kkhuzf3p 20 1 MERS MERS NNP cord-268388-kkhuzf3p 20 2 - - HYPH cord-268388-kkhuzf3p 20 3 CoV CoV NNP cord-268388-kkhuzf3p 20 4 uses use VBZ cord-268388-kkhuzf3p 20 5 the the DT cord-268388-kkhuzf3p 20 6 DPP4 DPP4 NNP cord-268388-kkhuzf3p 20 7 ( ( -LRB- cord-268388-kkhuzf3p 20 8 CD26 CD26 NNP cord-268388-kkhuzf3p 20 9 ) ) -RRB- cord-268388-kkhuzf3p 20 10 receptor receptor NN cord-268388-kkhuzf3p 20 11 to to TO cord-268388-kkhuzf3p 20 12 gain gain VB cord-268388-kkhuzf3p 20 13 entry entry NN cord-268388-kkhuzf3p 20 14 and and CC cord-268388-kkhuzf3p 20 15 effectively effectively RB cord-268388-kkhuzf3p 20 16 replicate replicate VB cord-268388-kkhuzf3p 20 17 in in IN cord-268388-kkhuzf3p 20 18 camel camel NN cord-268388-kkhuzf3p 20 19 cell cell NN cord-268388-kkhuzf3p 20 20 lines line NNS cord-268388-kkhuzf3p 20 21 [ [ -LRB- cord-268388-kkhuzf3p 20 22 9 9 CD cord-268388-kkhuzf3p 20 23 ] ] -RRB- cord-268388-kkhuzf3p 20 24 . . . cord-268388-kkhuzf3p 21 1 Neutralizing neutralize VBG cord-268388-kkhuzf3p 21 2 antibodies antibody NNS cord-268388-kkhuzf3p 21 3 for for IN cord-268388-kkhuzf3p 21 4 MERS MERS NNP cord-268388-kkhuzf3p 21 5 - - HYPH cord-268388-kkhuzf3p 21 6 CoV CoV NNP cord-268388-kkhuzf3p 21 7 have have VBP cord-268388-kkhuzf3p 21 8 been be VBN cord-268388-kkhuzf3p 21 9 detected detect VBN cord-268388-kkhuzf3p 21 10 in in IN cord-268388-kkhuzf3p 21 11 dromedary dromedary NN cord-268388-kkhuzf3p 21 12 camels camel NNS cord-268388-kkhuzf3p 21 13 from from IN cord-268388-kkhuzf3p 21 14 Oman Oman NNP cord-268388-kkhuzf3p 21 15 , , , cord-268388-kkhuzf3p 21 16 Canary Canary NNP cord-268388-kkhuzf3p 21 17 Islands Islands NNPS cord-268388-kkhuzf3p 21 18 , , , cord-268388-kkhuzf3p 21 19 Egypt Egypt NNP cord-268388-kkhuzf3p 21 20 , , , cord-268388-kkhuzf3p 21 21 Jordan Jordan NNP cord-268388-kkhuzf3p 21 22 , , , cord-268388-kkhuzf3p 21 23 United United NNP cord-268388-kkhuzf3p 21 24 Arab Arab NNP cord-268388-kkhuzf3p 21 25 Emirates Emirates NNPS cord-268388-kkhuzf3p 21 26 , , , cord-268388-kkhuzf3p 21 27 and and CC cord-268388-kkhuzf3p 21 28 Saudi Saudi NNP cord-268388-kkhuzf3p 21 29 Arabia Arabia NNP cord-268388-kkhuzf3p 21 30 [ [ -LRB- cord-268388-kkhuzf3p 21 31 10 10 CD cord-268388-kkhuzf3p 21 32 , , , cord-268388-kkhuzf3p 21 33 11 11 CD cord-268388-kkhuzf3p 21 34 ] ] -RRB- cord-268388-kkhuzf3p 21 35 . . . cord-268388-kkhuzf3p 22 1 The the DT cord-268388-kkhuzf3p 22 2 exact exact JJ cord-268388-kkhuzf3p 22 3 mode mode NN cord-268388-kkhuzf3p 22 4 of of IN cord-268388-kkhuzf3p 22 5 transmission transmission NN cord-268388-kkhuzf3p 22 6 from from IN cord-268388-kkhuzf3p 22 7 camels camel NNS cord-268388-kkhuzf3p 22 8 to to IN cord-268388-kkhuzf3p 22 9 humans human NNS cord-268388-kkhuzf3p 22 10 remains remain VBZ cord-268388-kkhuzf3p 22 11 to to TO cord-268388-kkhuzf3p 22 12 be be VB cord-268388-kkhuzf3p 22 13 confirmed confirm VBN cord-268388-kkhuzf3p 22 14 [ [ -LRB- cord-268388-kkhuzf3p 22 15 12 12 CD cord-268388-kkhuzf3p 22 16 ] ] -RRB- cord-268388-kkhuzf3p 22 17 . . . cord-268388-kkhuzf3p 23 1 Camel camel NN cord-268388-kkhuzf3p 23 2 milk milk NN cord-268388-kkhuzf3p 23 3 was be VBD cord-268388-kkhuzf3p 23 4 investigated investigate VBN cord-268388-kkhuzf3p 23 5 as as IN cord-268388-kkhuzf3p 23 6 a a DT cord-268388-kkhuzf3p 23 7 possible possible JJ cord-268388-kkhuzf3p 23 8 route route NN cord-268388-kkhuzf3p 23 9 of of IN cord-268388-kkhuzf3p 23 10 transmission transmission NN cord-268388-kkhuzf3p 23 11 , , , cord-268388-kkhuzf3p 23 12 given give VBN cord-268388-kkhuzf3p 23 13 the the DT cord-268388-kkhuzf3p 23 14 common common JJ cord-268388-kkhuzf3p 23 15 practice practice NN cord-268388-kkhuzf3p 23 16 of of IN cord-268388-kkhuzf3p 23 17 consuming consume VBG cord-268388-kkhuzf3p 23 18 camel camel NN cord-268388-kkhuzf3p 23 19 milk milk NN cord-268388-kkhuzf3p 23 20 in in IN cord-268388-kkhuzf3p 23 21 the the DT cord-268388-kkhuzf3p 23 22 Arabian Arabian NNP cord-268388-kkhuzf3p 23 23 Peninsula Peninsula NNP cord-268388-kkhuzf3p 23 24 . . . cord-268388-kkhuzf3p 24 1 The the DT cord-268388-kkhuzf3p 24 2 first first JJ cord-268388-kkhuzf3p 24 3 reported report VBN cord-268388-kkhuzf3p 24 4 case case NN cord-268388-kkhuzf3p 24 5 of of IN cord-268388-kkhuzf3p 24 6 MERS MERS NNP cord-268388-kkhuzf3p 24 7 - - HYPH cord-268388-kkhuzf3p 24 8 CoV CoV NNP cord-268388-kkhuzf3p 24 9 in in IN cord-268388-kkhuzf3p 24 10 Yemen Yemen NNP cord-268388-kkhuzf3p 24 11 occurred occur VBD cord-268388-kkhuzf3p 24 12 in in IN cord-268388-kkhuzf3p 24 13 a a DT cord-268388-kkhuzf3p 24 14 Yemeni yemeni JJ cord-268388-kkhuzf3p 24 15 pilot pilot NN cord-268388-kkhuzf3p 24 16 who who WP cord-268388-kkhuzf3p 24 17 consumed consume VBD cord-268388-kkhuzf3p 24 18 raw raw JJ cord-268388-kkhuzf3p 24 19 camel camel NN cord-268388-kkhuzf3p 24 20 milk milk NN cord-268388-kkhuzf3p 24 21 [ [ -LRB- cord-268388-kkhuzf3p 24 22 13 13 CD cord-268388-kkhuzf3p 24 23 ] ] -RRB- cord-268388-kkhuzf3p 24 24 , , , cord-268388-kkhuzf3p 24 25 and and CC cord-268388-kkhuzf3p 25 1 Reusken Reusken NNP cord-268388-kkhuzf3p 25 2 et et FW cord-268388-kkhuzf3p 25 3 al al NNP cord-268388-kkhuzf3p 25 4 . . NNP cord-268388-kkhuzf3p 25 5 reported report VBD cord-268388-kkhuzf3p 25 6 the the DT cord-268388-kkhuzf3p 25 7 finding finding NN cord-268388-kkhuzf3p 25 8 of of IN cord-268388-kkhuzf3p 25 9 MERS MERS NNP cord-268388-kkhuzf3p 25 10 - - HYPH cord-268388-kkhuzf3p 25 11 CoV CoV NNP cord-268388-kkhuzf3p 25 12 in in IN cord-268388-kkhuzf3p 25 13 camel camel NN cord-268388-kkhuzf3p 25 14 milk milk NN cord-268388-kkhuzf3p 25 15 in in IN cord-268388-kkhuzf3p 25 16 Qatar Qatar NNP cord-268388-kkhuzf3p 25 17 [ [ -LRB- cord-268388-kkhuzf3p 25 18 14 14 CD cord-268388-kkhuzf3p 25 19 ] ] -RRB- cord-268388-kkhuzf3p 25 20 . . . cord-268388-kkhuzf3p 26 1 However however RB cord-268388-kkhuzf3p 26 2 , , , cord-268388-kkhuzf3p 26 3 respiratory respiratory JJ cord-268388-kkhuzf3p 26 4 transmission transmission NN cord-268388-kkhuzf3p 26 5 is be VBZ cord-268388-kkhuzf3p 26 6 currently currently RB cord-268388-kkhuzf3p 26 7 considered consider VBN cord-268388-kkhuzf3p 26 8 as as IN cord-268388-kkhuzf3p 26 9 the the DT cord-268388-kkhuzf3p 26 10 most most RBS cord-268388-kkhuzf3p 26 11 likely likely JJ cord-268388-kkhuzf3p 26 12 route route NN cord-268388-kkhuzf3p 26 13 of of IN cord-268388-kkhuzf3p 26 14 transmission transmission NN cord-268388-kkhuzf3p 26 15 [ [ -LRB- cord-268388-kkhuzf3p 26 16 15 15 CD cord-268388-kkhuzf3p 26 17 ] ] -RRB- cord-268388-kkhuzf3p 26 18 . . . cord-268388-kkhuzf3p 27 1 MERS MERS NNP cord-268388-kkhuzf3p 27 2 - - HYPH cord-268388-kkhuzf3p 27 3 CoV CoV NNP cord-268388-kkhuzf3p 27 4 has have VBZ cord-268388-kkhuzf3p 27 5 been be VBN cord-268388-kkhuzf3p 27 6 detected detect VBN cord-268388-kkhuzf3p 27 7 by by IN cord-268388-kkhuzf3p 27 8 reverse reverse JJ cord-268388-kkhuzf3p 27 9 transcription transcription NN cord-268388-kkhuzf3p 27 10 PCR PCR NNP cord-268388-kkhuzf3p 27 11 ( ( -LRB- cord-268388-kkhuzf3p 27 12 RT RT NNP cord-268388-kkhuzf3p 27 13 - - HYPH cord-268388-kkhuzf3p 27 14 PCR PCR NNP cord-268388-kkhuzf3p 27 15 ) ) -RRB- cord-268388-kkhuzf3p 27 16 from from IN cord-268388-kkhuzf3p 27 17 the the DT cord-268388-kkhuzf3p 27 18 nasal nasal NN cord-268388-kkhuzf3p 27 19 swabs swab NNS cord-268388-kkhuzf3p 27 20 of of IN cord-268388-kkhuzf3p 27 21 three three CD cord-268388-kkhuzf3p 27 22 camels camel NNS cord-268388-kkhuzf3p 27 23 in in IN cord-268388-kkhuzf3p 27 24 Qatar Qatar NNP cord-268388-kkhuzf3p 27 25 and and CC cord-268388-kkhuzf3p 27 26 was be VBD cord-268388-kkhuzf3p 27 27 linked link VBN cord-268388-kkhuzf3p 27 28 to to IN cord-268388-kkhuzf3p 27 29 two two CD cord-268388-kkhuzf3p 27 30 confirmed confirm VBN cord-268388-kkhuzf3p 27 31 human human JJ cord-268388-kkhuzf3p 27 32 cases case NNS cord-268388-kkhuzf3p 27 33 with with IN cord-268388-kkhuzf3p 27 34 high high JJ cord-268388-kkhuzf3p 27 35 similarity similarity NN cord-268388-kkhuzf3p 27 36 upon upon IN cord-268388-kkhuzf3p 27 37 sequencing sequencing NN cord-268388-kkhuzf3p 27 38 , , , cord-268388-kkhuzf3p 27 39 suggesting suggest VBG cord-268388-kkhuzf3p 27 40 a a DT cord-268388-kkhuzf3p 27 41 possible possible JJ cord-268388-kkhuzf3p 27 42 respiratory respiratory JJ cord-268388-kkhuzf3p 27 43 mode mode NN cord-268388-kkhuzf3p 27 44 of of IN cord-268388-kkhuzf3p 27 45 transmission transmission NN cord-268388-kkhuzf3p 27 46 [ [ -LRB- cord-268388-kkhuzf3p 27 47 16 16 CD cord-268388-kkhuzf3p 27 48 ] ] -RRB- cord-268388-kkhuzf3p 27 49 . . . cord-268388-kkhuzf3p 28 1 Several several JJ cord-268388-kkhuzf3p 28 2 clusters cluster NNS cord-268388-kkhuzf3p 28 3 of of IN cord-268388-kkhuzf3p 28 4 MERS MERS NNP cord-268388-kkhuzf3p 28 5 - - HYPH cord-268388-kkhuzf3p 28 6 CoV cov NN cord-268388-kkhuzf3p 28 7 cases case NNS cord-268388-kkhuzf3p 28 8 have have VBP cord-268388-kkhuzf3p 28 9 been be VBN cord-268388-kkhuzf3p 28 10 reported report VBN cord-268388-kkhuzf3p 28 11 , , , cord-268388-kkhuzf3p 28 12 mainly mainly RB cord-268388-kkhuzf3p 28 13 among among IN cord-268388-kkhuzf3p 28 14 household household NN cord-268388-kkhuzf3p 28 15 members member NNS cord-268388-kkhuzf3p 28 16 and and CC cord-268388-kkhuzf3p 28 17 health health NN cord-268388-kkhuzf3p 28 18 care care NN cord-268388-kkhuzf3p 28 19 workers worker NNS cord-268388-kkhuzf3p 28 20 ( ( -LRB- cord-268388-kkhuzf3p 28 21 HCWs HCWs NNPS cord-268388-kkhuzf3p 28 22 ) ) -RRB- cord-268388-kkhuzf3p 28 23 , , , cord-268388-kkhuzf3p 28 24 suggesting suggest VBG cord-268388-kkhuzf3p 28 25 that that IN cord-268388-kkhuzf3p 28 26 transmission transmission NN cord-268388-kkhuzf3p 28 27 is be VBZ cord-268388-kkhuzf3p 28 28 through through IN cord-268388-kkhuzf3p 28 29 close close JJ cord-268388-kkhuzf3p 28 30 contact contact NN cord-268388-kkhuzf3p 28 31 . . . cord-268388-kkhuzf3p 29 1 The the DT cord-268388-kkhuzf3p 29 2 largest large JJS cord-268388-kkhuzf3p 29 3 cluster cluster NN cord-268388-kkhuzf3p 29 4 reported report VBD cord-268388-kkhuzf3p 29 5 so so RB cord-268388-kkhuzf3p 29 6 far far RB cord-268388-kkhuzf3p 29 7 has have VBZ cord-268388-kkhuzf3p 29 8 been be VBN cord-268388-kkhuzf3p 29 9 in in IN cord-268388-kkhuzf3p 29 10 23 23 CD cord-268388-kkhuzf3p 29 11 HCWs hcw NNS cord-268388-kkhuzf3p 29 12 in in IN cord-268388-kkhuzf3p 29 13 a a DT cord-268388-kkhuzf3p 29 14 hospital hospital NN cord-268388-kkhuzf3p 29 15 in in IN cord-268388-kkhuzf3p 29 16 Al Al NNP cord-268388-kkhuzf3p 29 17 Hasa Hasa NNP cord-268388-kkhuzf3p 29 18 , , , cord-268388-kkhuzf3p 29 19 Kingdom Kingdom NNP cord-268388-kkhuzf3p 29 20 of of IN cord-268388-kkhuzf3p 29 21 Saudi Saudi NNP cord-268388-kkhuzf3p 29 22 Arabia Arabia NNP cord-268388-kkhuzf3p 29 23 ( ( -LRB- cord-268388-kkhuzf3p 29 24 KSA KSA NNP cord-268388-kkhuzf3p 29 25 ) ) -RRB- cord-268388-kkhuzf3p 29 26 , , , cord-268388-kkhuzf3p 29 27 while while IN cord-268388-kkhuzf3p 29 28 the the DT cord-268388-kkhuzf3p 29 29 largest large JJS cord-268388-kkhuzf3p 29 30 family family NN cord-268388-kkhuzf3p 29 31 cluster cluster NN cord-268388-kkhuzf3p 29 32 has have VBZ cord-268388-kkhuzf3p 29 33 been be VBN cord-268388-kkhuzf3p 29 34 in in IN cord-268388-kkhuzf3p 29 35 three three CD cord-268388-kkhuzf3p 29 36 infected infected JJ cord-268388-kkhuzf3p 29 37 brothers brother NNS cord-268388-kkhuzf3p 29 38 from from IN cord-268388-kkhuzf3p 29 39 Riyadh Riyadh NNP cord-268388-kkhuzf3p 29 40 , , , cord-268388-kkhuzf3p 29 41 KSA KSA NNP cord-268388-kkhuzf3p 29 42 [ [ -LRB- cord-268388-kkhuzf3p 29 43 17 17 CD cord-268388-kkhuzf3p 29 44 , , , cord-268388-kkhuzf3p 29 45 18 18 CD cord-268388-kkhuzf3p 29 46 ] ] -RRB- cord-268388-kkhuzf3p 29 47 . . . cord-268388-kkhuzf3p 30 1 The the DT cord-268388-kkhuzf3p 30 2 basic basic JJ cord-268388-kkhuzf3p 30 3 reproductive reproductive JJ cord-268388-kkhuzf3p 30 4 rate rate NN cord-268388-kkhuzf3p 30 5 for for IN cord-268388-kkhuzf3p 30 6 MERS MERS NNP cord-268388-kkhuzf3p 30 7 - - HYPH cord-268388-kkhuzf3p 30 8 CoV CoV NNP cord-268388-kkhuzf3p 30 9 has have VBZ cord-268388-kkhuzf3p 30 10 still still RB cord-268388-kkhuzf3p 30 11 not not RB cord-268388-kkhuzf3p 30 12 been be VBN cord-268388-kkhuzf3p 30 13 determined determine VBN cord-268388-kkhuzf3p 30 14 with with IN cord-268388-kkhuzf3p 30 15 certainty certainty NN cord-268388-kkhuzf3p 30 16 [ [ -LRB- cord-268388-kkhuzf3p 30 17 11 11 CD cord-268388-kkhuzf3p 30 18 ] ] -RRB- cord-268388-kkhuzf3p 30 19 . . . cord-268388-kkhuzf3p 31 1 Using use VBG cord-268388-kkhuzf3p 31 2 two two CD cord-268388-kkhuzf3p 31 3 transmission transmission NN cord-268388-kkhuzf3p 31 4 scenarios scenario NNS cord-268388-kkhuzf3p 31 5 , , , cord-268388-kkhuzf3p 31 6 Breban Breban NNP cord-268388-kkhuzf3p 31 7 et et NNP cord-268388-kkhuzf3p 31 8 al al NNP cord-268388-kkhuzf3p 31 9 . . NNP cord-268388-kkhuzf3p 31 10 reported report VBD cord-268388-kkhuzf3p 31 11 an an DT cord-268388-kkhuzf3p 31 12 R r NN cord-268388-kkhuzf3p 31 13 0 0 CD cord-268388-kkhuzf3p 31 14 of of IN cord-268388-kkhuzf3p 31 15 0.60 0.60 CD cord-268388-kkhuzf3p 31 16 and and CC cord-268388-kkhuzf3p 31 17 0.69 0.69 CD cord-268388-kkhuzf3p 31 18 [ [ -LRB- cord-268388-kkhuzf3p 31 19 18 18 CD cord-268388-kkhuzf3p 31 20 ] ] -RRB- cord-268388-kkhuzf3p 31 21 . . . cord-268388-kkhuzf3p 32 1 Cauchemez Cauchemez NNP cord-268388-kkhuzf3p 32 2 et et NNP cord-268388-kkhuzf3p 32 3 al al NNP cord-268388-kkhuzf3p 32 4 . . NNP cord-268388-kkhuzf3p 32 5 reported report VBD cord-268388-kkhuzf3p 32 6 a a DT cord-268388-kkhuzf3p 32 7 similar similar JJ cord-268388-kkhuzf3p 32 8 R r NN cord-268388-kkhuzf3p 32 9 0 0 CD cord-268388-kkhuzf3p 32 10 at at IN cord-268388-kkhuzf3p 32 11 0.63 0.63 CD cord-268388-kkhuzf3p 32 12 , , , cord-268388-kkhuzf3p 32 13 but but CC cord-268388-kkhuzf3p 32 14 warned warn VBD cord-268388-kkhuzf3p 32 15 that that IN cord-268388-kkhuzf3p 32 16 in in IN cord-268388-kkhuzf3p 32 17 the the DT cord-268388-kkhuzf3p 32 18 absence absence NN cord-268388-kkhuzf3p 32 19 of of IN cord-268388-kkhuzf3p 32 20 infection infection NN cord-268388-kkhuzf3p 32 21 control control NN cord-268388-kkhuzf3p 32 22 measures measure NNS cord-268388-kkhuzf3p 32 23 , , , cord-268388-kkhuzf3p 32 24 R r NN cord-268388-kkhuzf3p 32 25 0 0 CD cord-268388-kkhuzf3p 32 26 may may MD cord-268388-kkhuzf3p 32 27 range range VB cord-268388-kkhuzf3p 32 28 from from IN cord-268388-kkhuzf3p 32 29 0.8 0.8 CD cord-268388-kkhuzf3p 32 30 - - SYM cord-268388-kkhuzf3p 32 31 1.3 1.3 CD cord-268388-kkhuzf3p 32 32 and and CC cord-268388-kkhuzf3p 32 33 could could MD cord-268388-kkhuzf3p 32 34 lead lead VB cord-268388-kkhuzf3p 32 35 to to IN cord-268388-kkhuzf3p 32 36 a a DT cord-268388-kkhuzf3p 32 37 self self NN cord-268388-kkhuzf3p 32 38 - - HYPH cord-268388-kkhuzf3p 32 39 sustaining sustain VBG cord-268388-kkhuzf3p 32 40 transmission transmission NN cord-268388-kkhuzf3p 32 41 [ [ -LRB- cord-268388-kkhuzf3p 32 42 19 19 CD cord-268388-kkhuzf3p 32 43 ] ] -RRB- cord-268388-kkhuzf3p 32 44 . . . cord-268388-kkhuzf3p 33 1 Propensity propensity NN cord-268388-kkhuzf3p 33 2 for for IN cord-268388-kkhuzf3p 33 3 the the DT cord-268388-kkhuzf3p 33 4 MERS MERS NNP cord-268388-kkhuzf3p 33 5 - - HYPH cord-268388-kkhuzf3p 33 6 CoV CoV NNP cord-268388-kkhuzf3p 33 7 to to TO cord-268388-kkhuzf3p 33 8 replicate replicate VB cord-268388-kkhuzf3p 33 9 in in IN cord-268388-kkhuzf3p 33 10 the the DT cord-268388-kkhuzf3p 33 11 lower low JJR cord-268388-kkhuzf3p 33 12 respiratory respiratory JJ cord-268388-kkhuzf3p 33 13 tract tract NN cord-268388-kkhuzf3p 33 14 may may MD cord-268388-kkhuzf3p 33 15 account account VB cord-268388-kkhuzf3p 33 16 for for IN cord-268388-kkhuzf3p 33 17 the the DT cord-268388-kkhuzf3p 33 18 observed observed JJ cord-268388-kkhuzf3p 33 19 limited limited JJ cord-268388-kkhuzf3p 33 20 transmission transmission NN cord-268388-kkhuzf3p 33 21 [ [ -LRB- cord-268388-kkhuzf3p 33 22 20 20 CD cord-268388-kkhuzf3p 33 23 ] ] -RRB- cord-268388-kkhuzf3p 33 24 . . . cord-268388-kkhuzf3p 34 1 The the DT cord-268388-kkhuzf3p 34 2 United United NNP cord-268388-kkhuzf3p 34 3 States States NNP cord-268388-kkhuzf3p 34 4 Centers Centers NNPS cord-268388-kkhuzf3p 34 5 for for IN cord-268388-kkhuzf3p 34 6 Disease Disease NNP cord-268388-kkhuzf3p 34 7 Control Control NNP cord-268388-kkhuzf3p 34 8 and and CC cord-268388-kkhuzf3p 34 9 Prevention Prevention NNP cord-268388-kkhuzf3p 34 10 ( ( -LRB- cord-268388-kkhuzf3p 34 11 CDC CDC NNP cord-268388-kkhuzf3p 34 12 ) ) -RRB- cord-268388-kkhuzf3p 34 13 recommends recommend VBZ cord-268388-kkhuzf3p 34 14 standard standard JJ cord-268388-kkhuzf3p 34 15 contact contact NN cord-268388-kkhuzf3p 34 16 and and CC cord-268388-kkhuzf3p 34 17 airborne airborne JJ cord-268388-kkhuzf3p 34 18 precautions precaution NNS cord-268388-kkhuzf3p 34 19 with with IN cord-268388-kkhuzf3p 34 20 the the DT cord-268388-kkhuzf3p 34 21 use use NN cord-268388-kkhuzf3p 34 22 of of IN cord-268388-kkhuzf3p 34 23 an an DT cord-268388-kkhuzf3p 34 24 N-95 N-95 NNP cord-268388-kkhuzf3p 34 25 mask mask NN cord-268388-kkhuzf3p 34 26 when when WRB cord-268388-kkhuzf3p 34 27 caring care VBG cord-268388-kkhuzf3p 34 28 for for IN cord-268388-kkhuzf3p 34 29 an an DT cord-268388-kkhuzf3p 34 30 infected infected JJ cord-268388-kkhuzf3p 34 31 patient patient NN cord-268388-kkhuzf3p 34 32 [ [ -LRB- cord-268388-kkhuzf3p 34 33 21 21 CD cord-268388-kkhuzf3p 34 34 ] ] -RRB- cord-268388-kkhuzf3p 34 35 . . . cord-268388-kkhuzf3p 35 1 The the DT cord-268388-kkhuzf3p 35 2 CDC CDC NNP cord-268388-kkhuzf3p 35 3 defines define VBZ cord-268388-kkhuzf3p 35 4 a a DT cord-268388-kkhuzf3p 35 5 laboratory laboratory NN cord-268388-kkhuzf3p 35 6 - - HYPH cord-268388-kkhuzf3p 35 7 confirmed confirm VBN cord-268388-kkhuzf3p 35 8 case case NN cord-268388-kkhuzf3p 35 9 of of IN cord-268388-kkhuzf3p 35 10 MERS MERS NNP cord-268388-kkhuzf3p 35 11 - - HYPH cord-268388-kkhuzf3p 35 12 CoV CoV NNP cord-268388-kkhuzf3p 35 13 as as IN cord-268388-kkhuzf3p 35 14 a a DT cord-268388-kkhuzf3p 35 15 patient patient NN cord-268388-kkhuzf3p 35 16 with with IN cord-268388-kkhuzf3p 35 17 a a DT cord-268388-kkhuzf3p 35 18 positive positive JJ cord-268388-kkhuzf3p 35 19 PCR pcr NN cord-268388-kkhuzf3p 35 20 from from IN cord-268388-kkhuzf3p 35 21 a a DT cord-268388-kkhuzf3p 35 22 respiratory respiratory JJ cord-268388-kkhuzf3p 35 23 sample sample NN cord-268388-kkhuzf3p 35 24 , , , cord-268388-kkhuzf3p 35 25 and and CC cord-268388-kkhuzf3p 35 26 a a DT cord-268388-kkhuzf3p 35 27 probable probable JJ cord-268388-kkhuzf3p 35 28 case case NN cord-268388-kkhuzf3p 35 29 as as IN cord-268388-kkhuzf3p 35 30 a a DT cord-268388-kkhuzf3p 35 31 patient patient NN cord-268388-kkhuzf3p 35 32 who who WP cord-268388-kkhuzf3p 35 33 had have VBD cord-268388-kkhuzf3p 35 34 close close JJ cord-268388-kkhuzf3p 35 35 contact contact NN cord-268388-kkhuzf3p 35 36 with with IN cord-268388-kkhuzf3p 35 37 a a DT cord-268388-kkhuzf3p 35 38 confirmed confirm VBN cord-268388-kkhuzf3p 35 39 case case NN cord-268388-kkhuzf3p 35 40 but but CC cord-268388-kkhuzf3p 35 41 inconclusive inconclusive JJ cord-268388-kkhuzf3p 35 42 laboratory laboratory NN cord-268388-kkhuzf3p 35 43 evidence evidence NN cord-268388-kkhuzf3p 35 44 [ [ -LRB- cord-268388-kkhuzf3p 35 45 22 22 CD cord-268388-kkhuzf3p 35 46 ] ] -RRB- cord-268388-kkhuzf3p 35 47 . . . cord-268388-kkhuzf3p 36 1 The the DT cord-268388-kkhuzf3p 36 2 incubation incubation NN cord-268388-kkhuzf3p 36 3 period period NN cord-268388-kkhuzf3p 36 4 for for IN cord-268388-kkhuzf3p 36 5 the the DT cord-268388-kkhuzf3p 36 6 presentation presentation NN cord-268388-kkhuzf3p 36 7 of of IN cord-268388-kkhuzf3p 36 8 MERS MERS NNP cord-268388-kkhuzf3p 36 9 - - HYPH cord-268388-kkhuzf3p 36 10 CoV cov NN cord-268388-kkhuzf3p 36 11 symptoms symptom NNS cord-268388-kkhuzf3p 36 12 is be VBZ cord-268388-kkhuzf3p 36 13 2 2 CD cord-268388-kkhuzf3p 36 14 - - SYM cord-268388-kkhuzf3p 36 15 14 14 CD cord-268388-kkhuzf3p 36 16 days day NNS cord-268388-kkhuzf3p 36 17 and and CC cord-268388-kkhuzf3p 36 18 it -PRON- PRP cord-268388-kkhuzf3p 36 19 remains remain VBZ cord-268388-kkhuzf3p 36 20 unknown unknown JJ cord-268388-kkhuzf3p 36 21 whether whether IN cord-268388-kkhuzf3p 36 22 patients patient NNS cord-268388-kkhuzf3p 36 23 are be VBP cord-268388-kkhuzf3p 36 24 infectious infectious JJ cord-268388-kkhuzf3p 36 25 during during IN cord-268388-kkhuzf3p 36 26 the the DT cord-268388-kkhuzf3p 36 27 incubation incubation NN cord-268388-kkhuzf3p 36 28 period period NN cord-268388-kkhuzf3p 36 29 [ [ -LRB- cord-268388-kkhuzf3p 36 30 23 23 CD cord-268388-kkhuzf3p 36 31 ] ] -RRB- cord-268388-kkhuzf3p 36 32 . . . cord-268388-kkhuzf3p 37 1 The the DT cord-268388-kkhuzf3p 37 2 average average JJ cord-268388-kkhuzf3p 37 3 age age NN cord-268388-kkhuzf3p 37 4 of of IN cord-268388-kkhuzf3p 37 5 presentation presentation NN cord-268388-kkhuzf3p 37 6 is be VBZ cord-268388-kkhuzf3p 37 7 50 50 CD cord-268388-kkhuzf3p 37 8 years year NNS cord-268388-kkhuzf3p 37 9 , , , cord-268388-kkhuzf3p 37 10 with with IN cord-268388-kkhuzf3p 37 11 a a DT cord-268388-kkhuzf3p 37 12 male male JJ cord-268388-kkhuzf3p 37 13 predominance predominance NN cord-268388-kkhuzf3p 37 14 [ [ -LRB- cord-268388-kkhuzf3p 37 15 24 24 CD cord-268388-kkhuzf3p 37 16 ] ] -RRB- cord-268388-kkhuzf3p 37 17 . . . cord-268388-kkhuzf3p 38 1 Clinically clinically RB cord-268388-kkhuzf3p 38 2 , , , cord-268388-kkhuzf3p 38 3 MERS MERS NNP cord-268388-kkhuzf3p 38 4 - - HYPH cord-268388-kkhuzf3p 38 5 CoV CoV NNP cord-268388-kkhuzf3p 38 6 causes cause VBZ cord-268388-kkhuzf3p 38 7 symptoms symptom NNS cord-268388-kkhuzf3p 38 8 of of IN cord-268388-kkhuzf3p 38 9 upper upper JJ cord-268388-kkhuzf3p 38 10 and and CC cord-268388-kkhuzf3p 38 11 lower low JJR cord-268388-kkhuzf3p 38 12 RTIs rti NNS cord-268388-kkhuzf3p 38 13 [ [ -LRB- cord-268388-kkhuzf3p 38 14 23 23 CD cord-268388-kkhuzf3p 38 15 ] ] -RRB- cord-268388-kkhuzf3p 38 16 . . . cord-268388-kkhuzf3p 39 1 The the DT cord-268388-kkhuzf3p 39 2 severity severity NN cord-268388-kkhuzf3p 39 3 of of IN cord-268388-kkhuzf3p 39 4 symptoms symptom NNS cord-268388-kkhuzf3p 39 5 varies vary VBZ cord-268388-kkhuzf3p 39 6 widely widely RB cord-268388-kkhuzf3p 39 7 . . . cord-268388-kkhuzf3p 40 1 Most Most JJS cord-268388-kkhuzf3p 40 2 asymptomatic asymptomatic JJ cord-268388-kkhuzf3p 40 3 cases case NNS cord-268388-kkhuzf3p 40 4 have have VBP cord-268388-kkhuzf3p 40 5 been be VBN cord-268388-kkhuzf3p 40 6 discovered discover VBN cord-268388-kkhuzf3p 40 7 through through IN cord-268388-kkhuzf3p 40 8 screening screening NN cord-268388-kkhuzf3p 40 9 after after IN cord-268388-kkhuzf3p 40 10 contact contact NN cord-268388-kkhuzf3p 40 11 with with IN cord-268388-kkhuzf3p 40 12 a a DT cord-268388-kkhuzf3p 40 13 known know VBN cord-268388-kkhuzf3p 40 14 case case NN cord-268388-kkhuzf3p 40 15 [ [ -LRB- cord-268388-kkhuzf3p 40 16 2 2 CD cord-268388-kkhuzf3p 40 17 ] ] -RRB- cord-268388-kkhuzf3p 40 18 . . . cord-268388-kkhuzf3p 41 1 Presenting present VBG cord-268388-kkhuzf3p 41 2 signs sign NNS cord-268388-kkhuzf3p 41 3 and and CC cord-268388-kkhuzf3p 41 4 symptoms symptom NNS cord-268388-kkhuzf3p 41 5 may may MD cord-268388-kkhuzf3p 41 6 include include VB cord-268388-kkhuzf3p 41 7 highgrade highgrade JJ cord-268388-kkhuzf3p 41 8 fever fever NN cord-268388-kkhuzf3p 41 9 , , , cord-268388-kkhuzf3p 41 10 non non JJ cord-268388-kkhuzf3p 41 11 - - JJ cord-268388-kkhuzf3p 41 12 productive productive JJ cord-268388-kkhuzf3p 41 13 cough cough NN cord-268388-kkhuzf3p 41 14 , , , cord-268388-kkhuzf3p 41 15 dyspnea dyspnea NN cord-268388-kkhuzf3p 41 16 , , , cord-268388-kkhuzf3p 41 17 headache headache NN cord-268388-kkhuzf3p 41 18 , , , cord-268388-kkhuzf3p 41 19 myalgia myalgia NN cord-268388-kkhuzf3p 41 20 , , , cord-268388-kkhuzf3p 41 21 nausea nausea NN cord-268388-kkhuzf3p 41 22 , , , cord-268388-kkhuzf3p 41 23 vomiting vomit VBG cord-268388-kkhuzf3p 41 24 , , , cord-268388-kkhuzf3p 41 25 and and CC cord-268388-kkhuzf3p 41 26 diarrhea diarrhea NN cord-268388-kkhuzf3p 41 27 that that WDT cord-268388-kkhuzf3p 41 28 may may MD cord-268388-kkhuzf3p 41 29 precede precede VB cord-268388-kkhuzf3p 41 30 the the DT cord-268388-kkhuzf3p 41 31 respiratory respiratory JJ cord-268388-kkhuzf3p 41 32 symptoms symptom NNS cord-268388-kkhuzf3p 41 33 [ [ -LRB- cord-268388-kkhuzf3p 41 34 25 25 CD cord-268388-kkhuzf3p 41 35 , , , cord-268388-kkhuzf3p 41 36 26 26 CD cord-268388-kkhuzf3p 41 37 ] ] -RRB- cord-268388-kkhuzf3p 41 38 . . . cord-268388-kkhuzf3p 42 1 Renal renal JJ cord-268388-kkhuzf3p 42 2 failure failure NN cord-268388-kkhuzf3p 42 3 has have VBZ cord-268388-kkhuzf3p 42 4 been be VBN cord-268388-kkhuzf3p 42 5 frequently frequently RB cord-268388-kkhuzf3p 42 6 reported report VBN cord-268388-kkhuzf3p 42 7 , , , cord-268388-kkhuzf3p 42 8 yet yet CC cord-268388-kkhuzf3p 42 9 no no DT cord-268388-kkhuzf3p 42 10 conclusive conclusive JJ cord-268388-kkhuzf3p 42 11 evidence evidence NN cord-268388-kkhuzf3p 42 12 of of IN cord-268388-kkhuzf3p 42 13 a a DT cord-268388-kkhuzf3p 42 14 direct direct JJ cord-268388-kkhuzf3p 42 15 viral viral JJ cord-268388-kkhuzf3p 42 16 invasion invasion NN cord-268388-kkhuzf3p 42 17 of of IN cord-268388-kkhuzf3p 42 18 renal renal JJ cord-268388-kkhuzf3p 42 19 tissues tissue NNS cord-268388-kkhuzf3p 42 20 exists exist VBZ cord-268388-kkhuzf3p 42 21 [ [ -LRB- cord-268388-kkhuzf3p 42 22 11 11 CD cord-268388-kkhuzf3p 42 23 , , , cord-268388-kkhuzf3p 42 24 27 27 CD cord-268388-kkhuzf3p 42 25 , , , cord-268388-kkhuzf3p 42 26 28 28 CD cord-268388-kkhuzf3p 42 27 ] ] -RRB- cord-268388-kkhuzf3p 42 28 . . . cord-268388-kkhuzf3p 43 1 Notably notably RB cord-268388-kkhuzf3p 43 2 , , , cord-268388-kkhuzf3p 43 3 most most JJS cord-268388-kkhuzf3p 43 4 patients patient NNS cord-268388-kkhuzf3p 43 5 who who WP cord-268388-kkhuzf3p 43 6 developed develop VBD cord-268388-kkhuzf3p 43 7 complications complication NNS cord-268388-kkhuzf3p 43 8 had have VBD cord-268388-kkhuzf3p 43 9 coexisting coexist VBG cord-268388-kkhuzf3p 43 10 medical medical JJ cord-268388-kkhuzf3p 43 11 co co NNS cord-268388-kkhuzf3p 43 12 - - NNS cord-268388-kkhuzf3p 43 13 morbidities morbidity NNS cord-268388-kkhuzf3p 43 14 [ [ -LRB- cord-268388-kkhuzf3p 43 15 11 11 CD cord-268388-kkhuzf3p 43 16 ] ] -RRB- cord-268388-kkhuzf3p 43 17 . . . cord-268388-kkhuzf3p 44 1 Laboratory laboratory NN cord-268388-kkhuzf3p 44 2 findings finding NNS cord-268388-kkhuzf3p 44 3 on on IN cord-268388-kkhuzf3p 44 4 admission admission NN cord-268388-kkhuzf3p 44 5 may may MD cord-268388-kkhuzf3p 44 6 include include VB cord-268388-kkhuzf3p 44 7 leukopenia leukopenia NN cord-268388-kkhuzf3p 44 8 , , , cord-268388-kkhuzf3p 44 9 lymphopenia lymphopenia NNP cord-268388-kkhuzf3p 44 10 , , , cord-268388-kkhuzf3p 44 11 thrombocytopenia thrombocytopenia NN cord-268388-kkhuzf3p 44 12 , , , cord-268388-kkhuzf3p 44 13 and and CC cord-268388-kkhuzf3p 44 14 elevated elevated JJ cord-268388-kkhuzf3p 44 15 lactate lactate NN cord-268388-kkhuzf3p 44 16 dehydrogenase dehydrogenase NN cord-268388-kkhuzf3p 44 17 levels level NNS cord-268388-kkhuzf3p 44 18 [ [ -LRB- cord-268388-kkhuzf3p 44 19 25 25 CD cord-268388-kkhuzf3p 44 20 ] ] -RRB- cord-268388-kkhuzf3p 44 21 . . . cord-268388-kkhuzf3p 45 1 MERS MERS NNP cord-268388-kkhuzf3p 45 2 - - HYPH cord-268388-kkhuzf3p 45 3 CoV CoV NNP cord-268388-kkhuzf3p 45 4 can can MD cord-268388-kkhuzf3p 45 5 also also RB cord-268388-kkhuzf3p 45 6 cause cause VB cord-268388-kkhuzf3p 45 7 severe severe JJ cord-268388-kkhuzf3p 45 8 pneumonia pneumonia NN cord-268388-kkhuzf3p 45 9 with with IN cord-268388-kkhuzf3p 45 10 acute acute JJ cord-268388-kkhuzf3p 45 11 respiratory respiratory JJ cord-268388-kkhuzf3p 45 12 distress distress NN cord-268388-kkhuzf3p 45 13 syndrome syndrome NN cord-268388-kkhuzf3p 45 14 ( ( -LRB- cord-268388-kkhuzf3p 45 15 ARDS ARDS NNP cord-268388-kkhuzf3p 45 16 ) ) -RRB- cord-268388-kkhuzf3p 45 17 , , , cord-268388-kkhuzf3p 45 18 requiring require VBG cord-268388-kkhuzf3p 45 19 mechanical mechanical JJ cord-268388-kkhuzf3p 45 20 ventilation ventilation NN cord-268388-kkhuzf3p 45 21 and and CC cord-268388-kkhuzf3p 45 22 intensive intensive JJ cord-268388-kkhuzf3p 45 23 care care NN cord-268388-kkhuzf3p 45 24 admission admission NN cord-268388-kkhuzf3p 45 25 [ [ -LRB- cord-268388-kkhuzf3p 45 26 24 24 CD cord-268388-kkhuzf3p 45 27 ] ] -RRB- cord-268388-kkhuzf3p 45 28 . . . cord-268388-kkhuzf3p 46 1 To to IN cord-268388-kkhuzf3p 46 2 date date NN cord-268388-kkhuzf3p 46 3 , , , cord-268388-kkhuzf3p 46 4 there there EX cord-268388-kkhuzf3p 46 5 is be VBZ cord-268388-kkhuzf3p 46 6 still still RB cord-268388-kkhuzf3p 46 7 a a DT cord-268388-kkhuzf3p 46 8 lack lack NN cord-268388-kkhuzf3p 46 9 of of IN cord-268388-kkhuzf3p 46 10 surgical surgical JJ cord-268388-kkhuzf3p 46 11 and and CC cord-268388-kkhuzf3p 46 12 pathological pathological JJ cord-268388-kkhuzf3p 46 13 information information NN cord-268388-kkhuzf3p 46 14 from from IN cord-268388-kkhuzf3p 46 15 patients patient NNS cord-268388-kkhuzf3p 46 16 infected infect VBN cord-268388-kkhuzf3p 46 17 with with IN cord-268388-kkhuzf3p 46 18 MERS MERS NNP cord-268388-kkhuzf3p 46 19 - - HYPH cord-268388-kkhuzf3p 46 20 CoV CoV NNP cord-268388-kkhuzf3p 46 21 , , , cord-268388-kkhuzf3p 46 22 which which WDT cord-268388-kkhuzf3p 46 23 hampers hamper VBZ cord-268388-kkhuzf3p 46 24 full full JJ cord-268388-kkhuzf3p 46 25 understanding understanding NN cord-268388-kkhuzf3p 46 26 of of IN cord-268388-kkhuzf3p 46 27 the the DT cord-268388-kkhuzf3p 46 28 pathogenesis pathogenesis NN cord-268388-kkhuzf3p 46 29 . . . cord-268388-kkhuzf3p 47 1 Lastly lastly RB cord-268388-kkhuzf3p 47 2 , , , cord-268388-kkhuzf3p 47 3 coinfection coinfection NN cord-268388-kkhuzf3p 47 4 with with IN cord-268388-kkhuzf3p 47 5 other other JJ cord-268388-kkhuzf3p 47 6 respiratory respiratory JJ cord-268388-kkhuzf3p 47 7 viruses virus NNS cord-268388-kkhuzf3p 47 8 and and CC cord-268388-kkhuzf3p 47 9 with with IN cord-268388-kkhuzf3p 47 10 community community NN cord-268388-kkhuzf3p 47 11 - - HYPH cord-268388-kkhuzf3p 47 12 acquired acquire VBN cord-268388-kkhuzf3p 47 13 bacteria bacteria NNS cord-268388-kkhuzf3p 47 14 has have VBZ cord-268388-kkhuzf3p 47 15 been be VBN cord-268388-kkhuzf3p 47 16 also also RB cord-268388-kkhuzf3p 47 17 reported report VBN cord-268388-kkhuzf3p 47 18 in in IN cord-268388-kkhuzf3p 47 19 MERS MERS NNP cord-268388-kkhuzf3p 47 20 - - HYPH cord-268388-kkhuzf3p 47 21 CoV cov NN cord-268388-kkhuzf3p 47 22 patients patient NNS cord-268388-kkhuzf3p 47 23 [ [ -LRB- cord-268388-kkhuzf3p 47 24 11 11 CD cord-268388-kkhuzf3p 47 25 , , , cord-268388-kkhuzf3p 47 26 29 29 CD cord-268388-kkhuzf3p 47 27 , , , cord-268388-kkhuzf3p 47 28 30 30 CD cord-268388-kkhuzf3p 47 29 ] ] -RRB- cord-268388-kkhuzf3p 47 30 . . . cord-268388-kkhuzf3p 48 1 As as IN cord-268388-kkhuzf3p 48 2 of of IN cord-268388-kkhuzf3p 48 3 June June NNP cord-268388-kkhuzf3p 48 4 26 26 CD cord-268388-kkhuzf3p 48 5 , , , cord-268388-kkhuzf3p 48 6 2014 2014 CD cord-268388-kkhuzf3p 48 7 , , , cord-268388-kkhuzf3p 48 8 WHO who WP cord-268388-kkhuzf3p 48 9 officially officially RB cord-268388-kkhuzf3p 48 10 reported report VBD cord-268388-kkhuzf3p 48 11 707 707 CD cord-268388-kkhuzf3p 48 12 affected affect VBN cord-268388-kkhuzf3p 48 13 patients patient NNS cord-268388-kkhuzf3p 48 14 in in IN cord-268388-kkhuzf3p 48 15 21 21 CD cord-268388-kkhuzf3p 48 16 countries country NNS cord-268388-kkhuzf3p 48 17 in in IN cord-268388-kkhuzf3p 48 18 three three CD cord-268388-kkhuzf3p 48 19 continents continent NNS cord-268388-kkhuzf3p 48 20 . . . cord-268388-kkhuzf3p 49 1 Two two CD cord-268388-kkhuzf3p 49 2 - - HYPH cord-268388-kkhuzf3p 49 3 hundred hundred CD cord-268388-kkhuzf3p 49 4 and and CC cord-268388-kkhuzf3p 49 5 fifty fifty CD cord-268388-kkhuzf3p 49 6 - - HYPH cord-268388-kkhuzf3p 49 7 two two CD cord-268388-kkhuzf3p 49 8 patients patient NNS cord-268388-kkhuzf3p 49 9 have have VBP cord-268388-kkhuzf3p 49 10 died die VBN cord-268388-kkhuzf3p 49 11 of of IN cord-268388-kkhuzf3p 49 12 MERS MERS NNP cord-268388-kkhuzf3p 49 13 - - HYPH cord-268388-kkhuzf3p 49 14 CoV CoV NNP cord-268388-kkhuzf3p 49 15 , , , cord-268388-kkhuzf3p 49 16 setting set VBG cord-268388-kkhuzf3p 49 17 the the DT cord-268388-kkhuzf3p 49 18 case case NN cord-268388-kkhuzf3p 49 19 fatality fatality NN cord-268388-kkhuzf3p 49 20 rate rate NN cord-268388-kkhuzf3p 49 21 at at IN cord-268388-kkhuzf3p 49 22 35 35 CD cord-268388-kkhuzf3p 49 23 % % NN cord-268388-kkhuzf3p 49 24 [ [ -LRB- cord-268388-kkhuzf3p 49 25 3 3 CD cord-268388-kkhuzf3p 49 26 ] ] -RRB- cord-268388-kkhuzf3p 49 27 . . . cord-268388-kkhuzf3p 50 1 The the DT cord-268388-kkhuzf3p 50 2 cases case NNS cord-268388-kkhuzf3p 50 3 so so RB cord-268388-kkhuzf3p 50 4 far far RB cord-268388-kkhuzf3p 50 5 have have VBP cord-268388-kkhuzf3p 50 6 been be VBN cord-268388-kkhuzf3p 50 7 acquired acquire VBN cord-268388-kkhuzf3p 50 8 either either RB cord-268388-kkhuzf3p 50 9 directly directly RB cord-268388-kkhuzf3p 50 10 through through IN cord-268388-kkhuzf3p 50 11 a a DT cord-268388-kkhuzf3p 50 12 probable probable JJ cord-268388-kkhuzf3p 50 13 zoonotic zoonotic JJ cord-268388-kkhuzf3p 50 14 source source NN cord-268388-kkhuzf3p 50 15 , , , cord-268388-kkhuzf3p 50 16 or or CC cord-268388-kkhuzf3p 50 17 as as IN cord-268388-kkhuzf3p 50 18 a a DT cord-268388-kkhuzf3p 50 19 result result NN cord-268388-kkhuzf3p 50 20 of of IN cord-268388-kkhuzf3p 50 21 human human JJ cord-268388-kkhuzf3p 50 22 - - HYPH cord-268388-kkhuzf3p 50 23 human human JJ cord-268388-kkhuzf3p 50 24 transmission transmission NN cord-268388-kkhuzf3p 50 25 via via IN cord-268388-kkhuzf3p 50 26 close close JJ cord-268388-kkhuzf3p 50 27 contact contact NN cord-268388-kkhuzf3p 50 28 . . . cord-268388-kkhuzf3p 51 1 Retrospective retrospective JJ cord-268388-kkhuzf3p 51 2 analysis analysis NN cord-268388-kkhuzf3p 51 3 tracked track VBD cord-268388-kkhuzf3p 51 4 the the DT cord-268388-kkhuzf3p 51 5 first first JJ cord-268388-kkhuzf3p 51 6 outbreak outbreak NN cord-268388-kkhuzf3p 51 7 to to IN cord-268388-kkhuzf3p 51 8 a a DT cord-268388-kkhuzf3p 51 9 hospital hospital NN cord-268388-kkhuzf3p 51 10 in in IN cord-268388-kkhuzf3p 51 11 the the DT cord-268388-kkhuzf3p 51 12 city city NN cord-268388-kkhuzf3p 51 13 of of IN cord-268388-kkhuzf3p 51 14 Al Al NNP cord-268388-kkhuzf3p 51 15 - - HYPH cord-268388-kkhuzf3p 51 16 Zarqa Zarqa NNP cord-268388-kkhuzf3p 51 17 in in IN cord-268388-kkhuzf3p 51 18 Jordan Jordan NNP cord-268388-kkhuzf3p 51 19 in in IN cord-268388-kkhuzf3p 51 20 April April NNP cord-268388-kkhuzf3p 51 21 2012 2012 CD cord-268388-kkhuzf3p 51 22 [ [ -LRB- cord-268388-kkhuzf3p 51 23 31 31 CD cord-268388-kkhuzf3p 51 24 ] ] -RRB- cord-268388-kkhuzf3p 51 25 . . . cord-268388-kkhuzf3p 52 1 An an DT cord-268388-kkhuzf3p 52 2 unexplained unexplained JJ cord-268388-kkhuzf3p 52 3 observation observation NN cord-268388-kkhuzf3p 52 4 has have VBZ cord-268388-kkhuzf3p 52 5 been be VBN cord-268388-kkhuzf3p 52 6 the the DT cord-268388-kkhuzf3p 52 7 seasonal seasonal JJ cord-268388-kkhuzf3p 52 8 variation variation NN cord-268388-kkhuzf3p 52 9 in in IN cord-268388-kkhuzf3p 52 10 reported report VBN cord-268388-kkhuzf3p 52 11 numbers number NNS cord-268388-kkhuzf3p 52 12 , , , cord-268388-kkhuzf3p 52 13 with with IN cord-268388-kkhuzf3p 52 14 a a DT cord-268388-kkhuzf3p 52 15 peak peak NN cord-268388-kkhuzf3p 52 16 between between IN cord-268388-kkhuzf3p 52 17 April April NNP cord-268388-kkhuzf3p 52 18 and and CC cord-268388-kkhuzf3p 52 19 June June NNP cord-268388-kkhuzf3p 52 20 of of IN cord-268388-kkhuzf3p 52 21 each each DT cord-268388-kkhuzf3p 52 22 year year NN cord-268388-kkhuzf3p 52 23 . . . cord-268388-kkhuzf3p 53 1 The the DT cord-268388-kkhuzf3p 53 2 number number NN cord-268388-kkhuzf3p 53 3 of of IN cord-268388-kkhuzf3p 53 4 cases case NNS cord-268388-kkhuzf3p 53 5 reported report VBN cord-268388-kkhuzf3p 53 6 during during IN cord-268388-kkhuzf3p 53 7 April April NNP cord-268388-kkhuzf3p 53 8 2014 2014 CD cord-268388-kkhuzf3p 53 9 alone alone RB cord-268388-kkhuzf3p 53 10 was be VBD cord-268388-kkhuzf3p 53 11 alarming alarming JJ cord-268388-kkhuzf3p 53 12 , , , cord-268388-kkhuzf3p 53 13 because because IN cord-268388-kkhuzf3p 53 14 it -PRON- PRP cord-268388-kkhuzf3p 53 15 was be VBD cord-268388-kkhuzf3p 53 16 greater great JJR cord-268388-kkhuzf3p 53 17 than than IN cord-268388-kkhuzf3p 53 18 the the DT cord-268388-kkhuzf3p 53 19 cumulative cumulative JJ cord-268388-kkhuzf3p 53 20 number number NN cord-268388-kkhuzf3p 53 21 of of IN cord-268388-kkhuzf3p 53 22 cases case NNS cord-268388-kkhuzf3p 53 23 reported report VBN cord-268388-kkhuzf3p 53 24 since since IN cord-268388-kkhuzf3p 53 25 the the DT cord-268388-kkhuzf3p 53 26 outbreak outbreak NN cord-268388-kkhuzf3p 53 27 began begin VBD cord-268388-kkhuzf3p 53 28 [ [ -LRB- cord-268388-kkhuzf3p 53 29 32 32 CD cord-268388-kkhuzf3p 53 30 ] ] -RRB- cord-268388-kkhuzf3p 53 31 . . . cord-268388-kkhuzf3p 54 1 The the DT cord-268388-kkhuzf3p 54 2 recent recent JJ cord-268388-kkhuzf3p 54 3 increase increase NN cord-268388-kkhuzf3p 54 4 in in IN cord-268388-kkhuzf3p 54 5 the the DT cord-268388-kkhuzf3p 54 6 number number NN cord-268388-kkhuzf3p 54 7 of of IN cord-268388-kkhuzf3p 54 8 infected infected JJ cord-268388-kkhuzf3p 54 9 patients patient NNS cord-268388-kkhuzf3p 54 10 may may MD cord-268388-kkhuzf3p 54 11 arguably arguably RB cord-268388-kkhuzf3p 54 12 be be VB cord-268388-kkhuzf3p 54 13 attributed attribute VBN cord-268388-kkhuzf3p 54 14 to to IN cord-268388-kkhuzf3p 54 15 better well JJR cord-268388-kkhuzf3p 54 16 case case NN cord-268388-kkhuzf3p 54 17 detection detection NN cord-268388-kkhuzf3p 54 18 and and CC cord-268388-kkhuzf3p 54 19 active active JJ cord-268388-kkhuzf3p 54 20 surveillance surveillance NN cord-268388-kkhuzf3p 54 21 programs program NNS cord-268388-kkhuzf3p 54 22 . . . cord-268388-kkhuzf3p 55 1 Yet yet CC cord-268388-kkhuzf3p 55 2 other other JJ cord-268388-kkhuzf3p 55 3 factors factor NNS cord-268388-kkhuzf3p 55 4 may may MD cord-268388-kkhuzf3p 55 5 have have VB cord-268388-kkhuzf3p 55 6 contributed contribute VBN cord-268388-kkhuzf3p 55 7 to to IN cord-268388-kkhuzf3p 55 8 the the DT cord-268388-kkhuzf3p 55 9 observed observed JJ cord-268388-kkhuzf3p 55 10 surge surge NN cord-268388-kkhuzf3p 55 11 , , , cord-268388-kkhuzf3p 55 12 including include VBG cord-268388-kkhuzf3p 55 13 suboptimal suboptimal JJ cord-268388-kkhuzf3p 55 14 infection infection NN cord-268388-kkhuzf3p 55 15 control control NN cord-268388-kkhuzf3p 55 16 practices practice NNS cord-268388-kkhuzf3p 55 17 in in IN cord-268388-kkhuzf3p 55 18 affected affected JJ cord-268388-kkhuzf3p 55 19 hospitals hospital NNS cord-268388-kkhuzf3p 55 20 in in IN cord-268388-kkhuzf3p 55 21 Saudi Saudi NNP cord-268388-kkhuzf3p 55 22 Arabia Arabia NNP cord-268388-kkhuzf3p 55 23 , , , cord-268388-kkhuzf3p 55 24 as as IN cord-268388-kkhuzf3p 55 25 documented document VBN cord-268388-kkhuzf3p 55 26 in in IN cord-268388-kkhuzf3p 55 27 a a DT cord-268388-kkhuzf3p 55 28 recent recent JJ cord-268388-kkhuzf3p 55 29 report report NN cord-268388-kkhuzf3p 55 30 of of IN cord-268388-kkhuzf3p 55 31 the the DT cord-268388-kkhuzf3p 55 32 WHO WHO NNP cord-268388-kkhuzf3p 55 33 mission mission NN cord-268388-kkhuzf3p 55 34 to to IN cord-268388-kkhuzf3p 55 35 Jeddah Jeddah NNP cord-268388-kkhuzf3p 55 36 [ [ -LRB- cord-268388-kkhuzf3p 55 37 33 33 CD cord-268388-kkhuzf3p 55 38 ] ] -RRB- cord-268388-kkhuzf3p 55 39 . . . cord-268388-kkhuzf3p 56 1 Another another DT cord-268388-kkhuzf3p 56 2 explanation explanation NN cord-268388-kkhuzf3p 56 3 for for IN cord-268388-kkhuzf3p 56 4 the the DT cord-268388-kkhuzf3p 56 5 seasonal seasonal JJ cord-268388-kkhuzf3p 56 6 variation variation NN cord-268388-kkhuzf3p 56 7 may may MD cord-268388-kkhuzf3p 56 8 be be VB cord-268388-kkhuzf3p 56 9 that that IN cord-268388-kkhuzf3p 56 10 it -PRON- PRP cord-268388-kkhuzf3p 56 11 coincides coincide VBZ cord-268388-kkhuzf3p 56 12 with with IN cord-268388-kkhuzf3p 56 13 camel camel NN cord-268388-kkhuzf3p 56 14 birthing birthing NN cord-268388-kkhuzf3p 56 15 season season NN cord-268388-kkhuzf3p 56 16 , , , cord-268388-kkhuzf3p 56 17 and and CC cord-268388-kkhuzf3p 56 18 younger young JJR cord-268388-kkhuzf3p 56 19 camels camel NNS cord-268388-kkhuzf3p 56 20 seem seem VBP cord-268388-kkhuzf3p 56 21 to to TO cord-268388-kkhuzf3p 56 22 be be VB cord-268388-kkhuzf3p 56 23 more more RBR cord-268388-kkhuzf3p 56 24 often often RB cord-268388-kkhuzf3p 56 25 infected infect VBN cord-268388-kkhuzf3p 56 26 than than IN cord-268388-kkhuzf3p 56 27 their -PRON- PRP$ cord-268388-kkhuzf3p 56 28 older old JJR cord-268388-kkhuzf3p 56 29 counterparts counterpart NNS cord-268388-kkhuzf3p 56 30 [ [ -LRB- cord-268388-kkhuzf3p 56 31 34 34 CD cord-268388-kkhuzf3p 56 32 ] ] -RRB- cord-268388-kkhuzf3p 56 33 . . . cord-268388-kkhuzf3p 57 1 The the DT cord-268388-kkhuzf3p 57 2 distribution distribution NN cord-268388-kkhuzf3p 57 3 of of IN cord-268388-kkhuzf3p 57 4 the the DT cord-268388-kkhuzf3p 57 5 total total JJ cord-268388-kkhuzf3p 57 6 reported report VBN cord-268388-kkhuzf3p 57 7 cases case NNS cord-268388-kkhuzf3p 57 8 by by IN cord-268388-kkhuzf3p 57 9 country country NN cord-268388-kkhuzf3p 57 10 is be VBZ cord-268388-kkhuzf3p 57 11 as as IN cord-268388-kkhuzf3p 57 12 follows follow VBZ cord-268388-kkhuzf3p 57 13 : : : cord-268388-kkhuzf3p 57 14 85.8 85.8 CD cord-268388-kkhuzf3p 57 15 % % NN cord-268388-kkhuzf3p 57 16 in in IN cord-268388-kkhuzf3p 57 17 the the DT cord-268388-kkhuzf3p 57 18 KSA KSA NNP cord-268388-kkhuzf3p 57 19 , , , cord-268388-kkhuzf3p 57 20 8.1 8.1 CD cord-268388-kkhuzf3p 57 21 % % NN cord-268388-kkhuzf3p 57 22 in in IN cord-268388-kkhuzf3p 57 23 the the DT cord-268388-kkhuzf3p 57 24 United United NNP cord-268388-kkhuzf3p 57 25 Arab Arab NNP cord-268388-kkhuzf3p 57 26 Emirates Emirates NNPS cord-268388-kkhuzf3p 57 27 , , , cord-268388-kkhuzf3p 57 28 1.7 1.7 CD cord-268388-kkhuzf3p 57 29 % % NN cord-268388-kkhuzf3p 57 30 in in IN cord-268388-kkhuzf3p 57 31 Jordan Jordan NNP cord-268388-kkhuzf3p 57 32 , , , cord-268388-kkhuzf3p 57 33 and and CC cord-268388-kkhuzf3p 57 34 1 1 CD cord-268388-kkhuzf3p 57 35 % % NN cord-268388-kkhuzf3p 57 36 in in IN cord-268388-kkhuzf3p 57 37 Qatar Qatar NNP cord-268388-kkhuzf3p 57 38 [ [ -LRB- cord-268388-kkhuzf3p 57 39 32 32 CD cord-268388-kkhuzf3p 57 40 ] ] -RRB- cord-268388-kkhuzf3p 57 41 . . . cord-268388-kkhuzf3p 58 1 Cases case NNS cord-268388-kkhuzf3p 58 2 have have VBP cord-268388-kkhuzf3p 58 3 also also RB cord-268388-kkhuzf3p 58 4 been be VBN cord-268388-kkhuzf3p 58 5 reported report VBN cord-268388-kkhuzf3p 58 6 in in IN cord-268388-kkhuzf3p 58 7 Kuwait Kuwait NNP cord-268388-kkhuzf3p 58 8 , , , cord-268388-kkhuzf3p 58 9 Yemen Yemen NNP cord-268388-kkhuzf3p 58 10 , , , cord-268388-kkhuzf3p 58 11 Oman Oman NNP cord-268388-kkhuzf3p 58 12 , , , cord-268388-kkhuzf3p 58 13 Iran Iran NNP cord-268388-kkhuzf3p 58 14 , , , cord-268388-kkhuzf3p 58 15 Lebanon Lebanon NNP cord-268388-kkhuzf3p 58 16 , , , cord-268388-kkhuzf3p 58 17 Tunisia Tunisia NNP cord-268388-kkhuzf3p 58 18 , , , cord-268388-kkhuzf3p 58 19 Algeria Algeria NNP cord-268388-kkhuzf3p 58 20 , , , cord-268388-kkhuzf3p 58 21 Bangladesh Bangladesh NNP cord-268388-kkhuzf3p 58 22 , , , cord-268388-kkhuzf3p 58 23 Malaysia Malaysia NNP cord-268388-kkhuzf3p 58 24 , , , cord-268388-kkhuzf3p 58 25 France France NNP cord-268388-kkhuzf3p 58 26 , , , cord-268388-kkhuzf3p 58 27 Italy Italy NNP cord-268388-kkhuzf3p 58 28 , , , cord-268388-kkhuzf3p 58 29 Germany Germany NNP cord-268388-kkhuzf3p 58 30 , , , cord-268388-kkhuzf3p 58 31 the the DT cord-268388-kkhuzf3p 58 32 Netherlands Netherlands NNP cord-268388-kkhuzf3p 58 33 , , , cord-268388-kkhuzf3p 58 34 United United NNP cord-268388-kkhuzf3p 58 35 Kingdom Kingdom NNP cord-268388-kkhuzf3p 58 36 , , , cord-268388-kkhuzf3p 58 37 Greece Greece NNP cord-268388-kkhuzf3p 58 38 , , , cord-268388-kkhuzf3p 58 39 Italy Italy NNP cord-268388-kkhuzf3p 58 40 , , , cord-268388-kkhuzf3p 58 41 and and CC cord-268388-kkhuzf3p 58 42 the the DT cord-268388-kkhuzf3p 58 43 United United NNP cord-268388-kkhuzf3p 58 44 States States NNP cord-268388-kkhuzf3p 58 45 [ [ -LRB- cord-268388-kkhuzf3p 58 46 32 32 CD cord-268388-kkhuzf3p 58 47 ] ] -RRB- cord-268388-kkhuzf3p 58 48 . . . cord-268388-kkhuzf3p 59 1 Furthermore furthermore RB cord-268388-kkhuzf3p 59 2 , , , cord-268388-kkhuzf3p 59 3 seropositive seropositive JJ cord-268388-kkhuzf3p 59 4 camels camel NNS cord-268388-kkhuzf3p 59 5 for for IN cord-268388-kkhuzf3p 59 6 MERS MERS NNP cord-268388-kkhuzf3p 59 7 - - HYPH cord-268388-kkhuzf3p 59 8 CoV CoV NNP cord-268388-kkhuzf3p 59 9 were be VBD cord-268388-kkhuzf3p 59 10 detected detect VBN cord-268388-kkhuzf3p 59 11 in in IN cord-268388-kkhuzf3p 59 12 Egypt Egypt NNP cord-268388-kkhuzf3p 59 13 , , , cord-268388-kkhuzf3p 59 14 Kenya Kenya NNP cord-268388-kkhuzf3p 59 15 , , , cord-268388-kkhuzf3p 59 16 Nigeria Nigeria NNP cord-268388-kkhuzf3p 59 17 , , , cord-268388-kkhuzf3p 59 18 Tunisia Tunisia NNP cord-268388-kkhuzf3p 59 19 , , , cord-268388-kkhuzf3p 59 20 and and CC cord-268388-kkhuzf3p 59 21 Ethiopia Ethiopia NNP cord-268388-kkhuzf3p 59 22 , , , cord-268388-kkhuzf3p 59 23 suggesting suggest VBG cord-268388-kkhuzf3p 59 24 that that IN cord-268388-kkhuzf3p 59 25 there there EX cord-268388-kkhuzf3p 59 26 may may MD cord-268388-kkhuzf3p 59 27 be be VB cord-268388-kkhuzf3p 59 28 MERS MERS NNP cord-268388-kkhuzf3p 59 29 - - HYPH cord-268388-kkhuzf3p 59 30 CoV cov NN cord-268388-kkhuzf3p 59 31 cases case NNS cord-268388-kkhuzf3p 59 32 that that WDT cord-268388-kkhuzf3p 59 33 are be VBP cord-268388-kkhuzf3p 59 34 undetected undetected JJ cord-268388-kkhuzf3p 59 35 in in IN cord-268388-kkhuzf3p 59 36 Africa Africa NNP cord-268388-kkhuzf3p 59 37 [ [ -LRB- cord-268388-kkhuzf3p 59 38 8 8 CD cord-268388-kkhuzf3p 59 39 , , , cord-268388-kkhuzf3p 59 40 35 35 CD cord-268388-kkhuzf3p 59 41 , , , cord-268388-kkhuzf3p 59 42 36 36 CD cord-268388-kkhuzf3p 59 43 ] ] -RRB- cord-268388-kkhuzf3p 59 44 . . . cord-268388-kkhuzf3p 60 1 In in IN cord-268388-kkhuzf3p 60 2 2012 2012 CD cord-268388-kkhuzf3p 60 3 , , , cord-268388-kkhuzf3p 60 4 3,161,573 3,161,573 CD cord-268388-kkhuzf3p 60 5 Muslims Muslims NNPS cord-268388-kkhuzf3p 60 6 from from IN cord-268388-kkhuzf3p 60 7 188 188 CD cord-268388-kkhuzf3p 60 8 countries country NNS cord-268388-kkhuzf3p 60 9 gathered gather VBD cord-268388-kkhuzf3p 60 10 in in IN cord-268388-kkhuzf3p 60 11 Mecca Mecca NNP cord-268388-kkhuzf3p 60 12 to to TO cord-268388-kkhuzf3p 60 13 perform perform VB cord-268388-kkhuzf3p 60 14 the the DT cord-268388-kkhuzf3p 60 15 annual annual JJ cord-268388-kkhuzf3p 60 16 Hajj Hajj NNP cord-268388-kkhuzf3p 60 17 , , , cord-268388-kkhuzf3p 60 18 the the DT cord-268388-kkhuzf3p 60 19 largest large JJS cord-268388-kkhuzf3p 60 20 gathering gathering NN cord-268388-kkhuzf3p 60 21 of of IN cord-268388-kkhuzf3p 60 22 Muslims Muslims NNPS cord-268388-kkhuzf3p 60 23 in in IN cord-268388-kkhuzf3p 60 24 the the DT cord-268388-kkhuzf3p 60 25 world world NN cord-268388-kkhuzf3p 60 26 . . . cord-268388-kkhuzf3p 61 1 The the DT cord-268388-kkhuzf3p 61 2 identification identification NN cord-268388-kkhuzf3p 61 3 of of IN cord-268388-kkhuzf3p 61 4 MERS MERS NNP cord-268388-kkhuzf3p 61 5 - - HYPH cord-268388-kkhuzf3p 61 6 CoV CoV NNP cord-268388-kkhuzf3p 61 7 in in IN cord-268388-kkhuzf3p 61 8 Saudi Saudi NNP cord-268388-kkhuzf3p 61 9 Arabia Arabia NNP cord-268388-kkhuzf3p 61 10 has have VBZ cord-268388-kkhuzf3p 61 11 generated generate VBN cord-268388-kkhuzf3p 61 12 international international JJ cord-268388-kkhuzf3p 61 13 concern concern NN cord-268388-kkhuzf3p 61 14 of of IN cord-268388-kkhuzf3p 61 15 a a DT cord-268388-kkhuzf3p 61 16 global global JJ cord-268388-kkhuzf3p 61 17 pandemic pandemic NN cord-268388-kkhuzf3p 61 18 . . . cord-268388-kkhuzf3p 62 1 As as IN cord-268388-kkhuzf3p 62 2 a a DT cord-268388-kkhuzf3p 62 3 response response NN cord-268388-kkhuzf3p 62 4 , , , cord-268388-kkhuzf3p 62 5 the the DT cord-268388-kkhuzf3p 62 6 Saudi saudi JJ cord-268388-kkhuzf3p 62 7 government government NN cord-268388-kkhuzf3p 62 8 requested request VBD cord-268388-kkhuzf3p 62 9 that that IN cord-268388-kkhuzf3p 62 10 elderly elderly JJ cord-268388-kkhuzf3p 62 11 and and CC cord-268388-kkhuzf3p 62 12 chronically chronically RB cord-268388-kkhuzf3p 62 13 ill ill JJ cord-268388-kkhuzf3p 62 14 Muslims Muslims NNPS cord-268388-kkhuzf3p 62 15 avoid avoid VBP cord-268388-kkhuzf3p 62 16 Hajj Hajj NNP cord-268388-kkhuzf3p 62 17 in in IN cord-268388-kkhuzf3p 62 18 2013 2013 CD cord-268388-kkhuzf3p 62 19 and and CC cord-268388-kkhuzf3p 62 20 restricted restrict VBD cord-268388-kkhuzf3p 62 21 the the DT cord-268388-kkhuzf3p 62 22 number number NN cord-268388-kkhuzf3p 62 23 of of IN cord-268388-kkhuzf3p 62 24 pilgrims pilgrim NNS cord-268388-kkhuzf3p 62 25 to to IN cord-268388-kkhuzf3p 62 26 2,061,573 2,061,573 CD cord-268388-kkhuzf3p 62 27 . . . cord-268388-kkhuzf3p 63 1 Consequently consequently RB cord-268388-kkhuzf3p 63 2 , , , cord-268388-kkhuzf3p 63 3 no no DT cord-268388-kkhuzf3p 63 4 cases case NNS cord-268388-kkhuzf3p 63 5 were be VBD cord-268388-kkhuzf3p 63 6 reported report VBN cord-268388-kkhuzf3p 63 7 during during IN cord-268388-kkhuzf3p 63 8 the the DT cord-268388-kkhuzf3p 63 9 pilgrimage pilgrimage NN cord-268388-kkhuzf3p 63 10 of of IN cord-268388-kkhuzf3p 63 11 that that DT cord-268388-kkhuzf3p 63 12 year year NN cord-268388-kkhuzf3p 63 13 [ [ -LRB- cord-268388-kkhuzf3p 63 14 37 37 CD cord-268388-kkhuzf3p 63 15 ] ] -RRB- cord-268388-kkhuzf3p 63 16 . . . cord-268388-kkhuzf3p 64 1 Nasopharyngeal nasopharyngeal JJ cord-268388-kkhuzf3p 64 2 specimens specimen NNS cord-268388-kkhuzf3p 64 3 collected collect VBN cord-268388-kkhuzf3p 64 4 from from IN cord-268388-kkhuzf3p 64 5 5,235 5,235 CD cord-268388-kkhuzf3p 64 6 pilgrims pilgrim NNS cord-268388-kkhuzf3p 64 7 revealed reveal VBD cord-268388-kkhuzf3p 64 8 no no DT cord-268388-kkhuzf3p 64 9 cases case NNS cord-268388-kkhuzf3p 64 10 of of IN cord-268388-kkhuzf3p 64 11 MERS MERS NNP cord-268388-kkhuzf3p 64 12 - - HYPH cord-268388-kkhuzf3p 64 13 CoV CoV NNP cord-268388-kkhuzf3p 64 14 nasal nasal NN cord-268388-kkhuzf3p 64 15 carriage carriage NN cord-268388-kkhuzf3p 64 16 [ [ -LRB- cord-268388-kkhuzf3p 64 17 38 38 CD cord-268388-kkhuzf3p 64 18 ] ] -RRB- cord-268388-kkhuzf3p 64 19 . . . cord-268388-kkhuzf3p 65 1 A a DT cord-268388-kkhuzf3p 65 2 prospective prospective JJ cord-268388-kkhuzf3p 65 3 cohort cohort NN cord-268388-kkhuzf3p 65 4 study study NN cord-268388-kkhuzf3p 65 5 of of IN cord-268388-kkhuzf3p 65 6 129 129 CD cord-268388-kkhuzf3p 65 7 French french JJ cord-268388-kkhuzf3p 65 8 pilgrims pilgrim NNS cord-268388-kkhuzf3p 65 9 did do VBD cord-268388-kkhuzf3p 65 10 not not RB cord-268388-kkhuzf3p 65 11 reveal reveal VB cord-268388-kkhuzf3p 65 12 any any DT cord-268388-kkhuzf3p 65 13 MERS MERS NNP cord-268388-kkhuzf3p 65 14 - - HYPH cord-268388-kkhuzf3p 65 15 CoV cov NN cord-268388-kkhuzf3p 65 16 cases case NNS cord-268388-kkhuzf3p 65 17 [ [ -LRB- cord-268388-kkhuzf3p 65 18 39 39 CD cord-268388-kkhuzf3p 65 19 ] ] -RRB- cord-268388-kkhuzf3p 65 20 . . . cord-268388-kkhuzf3p 66 1 Nevertheless nevertheless RB cord-268388-kkhuzf3p 66 2 , , , cord-268388-kkhuzf3p 66 3 the the DT cord-268388-kkhuzf3p 66 4 potential potential NN cord-268388-kkhuzf3p 66 5 for for IN cord-268388-kkhuzf3p 66 6 spreading spread VBG cord-268388-kkhuzf3p 66 7 of of IN cord-268388-kkhuzf3p 66 8 MERS MERS NNP cord-268388-kkhuzf3p 66 9 - - HYPH cord-268388-kkhuzf3p 66 10 CoV CoV NNP cord-268388-kkhuzf3p 66 11 during during IN cord-268388-kkhuzf3p 66 12 the the DT cord-268388-kkhuzf3p 66 13 2014 2014 CD cord-268388-kkhuzf3p 66 14 Hajj Hajj NNP cord-268388-kkhuzf3p 66 15 season season NN cord-268388-kkhuzf3p 66 16 ( ( -LRB- cord-268388-kkhuzf3p 66 17 October October NNP cord-268388-kkhuzf3p 66 18 2 2 CD cord-268388-kkhuzf3p 66 19 - - SYM cord-268388-kkhuzf3p 66 20 6 6 CD cord-268388-kkhuzf3p 66 21 ) ) -RRB- cord-268388-kkhuzf3p 66 22 remains remain VBZ cord-268388-kkhuzf3p 66 23 possible possible JJ cord-268388-kkhuzf3p 66 24 , , , cord-268388-kkhuzf3p 66 25 especially especially RB cord-268388-kkhuzf3p 66 26 since since IN cord-268388-kkhuzf3p 66 27 documented document VBN cord-268388-kkhuzf3p 66 28 transmission transmission NN cord-268388-kkhuzf3p 66 29 occurred occur VBD cord-268388-kkhuzf3p 66 30 this this DT cord-268388-kkhuzf3p 66 31 year year NN cord-268388-kkhuzf3p 66 32 in in IN cord-268388-kkhuzf3p 66 33 patients patient NNS cord-268388-kkhuzf3p 66 34 from from IN cord-268388-kkhuzf3p 66 35 Iran Iran NNP cord-268388-kkhuzf3p 66 36 and and CC cord-268388-kkhuzf3p 66 37 Malaysia Malaysia NNP cord-268388-kkhuzf3p 66 38 after after IN cord-268388-kkhuzf3p 66 39 their -PRON- PRP$ cord-268388-kkhuzf3p 66 40 return return NN cord-268388-kkhuzf3p 66 41 from from IN cord-268388-kkhuzf3p 66 42 Umrah Umrah NNP cord-268388-kkhuzf3p 66 43 in in IN cord-268388-kkhuzf3p 66 44 Mecca Mecca NNP cord-268388-kkhuzf3p 66 45 . . . cord-268388-kkhuzf3p 67 1 It -PRON- PRP cord-268388-kkhuzf3p 67 2 is be VBZ cord-268388-kkhuzf3p 67 3 worth worth JJ cord-268388-kkhuzf3p 67 4 noting note VBG cord-268388-kkhuzf3p 67 5 that that IN cord-268388-kkhuzf3p 67 6 the the DT cord-268388-kkhuzf3p 67 7 two two CD cord-268388-kkhuzf3p 67 8 most most RBS cord-268388-kkhuzf3p 67 9 frequently frequently RB cord-268388-kkhuzf3p 67 10 visited visit VBN cord-268388-kkhuzf3p 67 11 cities city NNS cord-268388-kkhuzf3p 67 12 during during IN cord-268388-kkhuzf3p 67 13 the the DT cord-268388-kkhuzf3p 67 14 Hajj Hajj NNP cord-268388-kkhuzf3p 67 15 , , , cord-268388-kkhuzf3p 67 16 Mecca Mecca NNP cord-268388-kkhuzf3p 67 17 and and CC cord-268388-kkhuzf3p 67 18 Medina Medina NNP cord-268388-kkhuzf3p 67 19 , , , cord-268388-kkhuzf3p 67 20 have have VBP cord-268388-kkhuzf3p 67 21 so so RB cord-268388-kkhuzf3p 67 22 far far RB cord-268388-kkhuzf3p 67 23 reported report VBN cord-268388-kkhuzf3p 67 24 32 32 CD cord-268388-kkhuzf3p 67 25 and and CC cord-268388-kkhuzf3p 67 26 35 35 CD cord-268388-kkhuzf3p 67 27 cases case NNS cord-268388-kkhuzf3p 67 28 respectively respectively RB cord-268388-kkhuzf3p 67 29 [ [ -LRB- cord-268388-kkhuzf3p 67 30 32 32 CD cord-268388-kkhuzf3p 67 31 ] ] -RRB- cord-268388-kkhuzf3p 67 32 . . . cord-268388-kkhuzf3p 68 1 MERS MERS NNP cord-268388-kkhuzf3p 68 2 - - HYPH cord-268388-kkhuzf3p 68 3 CoV CoV NNP cord-268388-kkhuzf3p 68 4 binds bind VBZ cord-268388-kkhuzf3p 68 5 to to IN cord-268388-kkhuzf3p 68 6 the the DT cord-268388-kkhuzf3p 68 7 DPP4 DPP4 NNP cord-268388-kkhuzf3p 68 8 ( ( -LRB- cord-268388-kkhuzf3p 68 9 CD26 CD26 NNP cord-268388-kkhuzf3p 68 10 ) ) -RRB- cord-268388-kkhuzf3p 68 11 surface surface NN cord-268388-kkhuzf3p 68 12 receptor receptor NN cord-268388-kkhuzf3p 68 13 using use VBG cord-268388-kkhuzf3p 68 14 the the DT cord-268388-kkhuzf3p 68 15 spike spike NN cord-268388-kkhuzf3p 68 16 ( ( -LRB- cord-268388-kkhuzf3p 68 17 S s NN cord-268388-kkhuzf3p 68 18 ) ) -RRB- cord-268388-kkhuzf3p 68 19 surface surface NN cord-268388-kkhuzf3p 68 20 protein protein NN cord-268388-kkhuzf3p 68 21 with with IN cord-268388-kkhuzf3p 68 22 subsequent subsequent JJ cord-268388-kkhuzf3p 68 23 cell cell NN cord-268388-kkhuzf3p 68 24 entry entry NN cord-268388-kkhuzf3p 68 25 [ [ -LRB- cord-268388-kkhuzf3p 68 26 40 40 CD cord-268388-kkhuzf3p 68 27 ] ] -RRB- cord-268388-kkhuzf3p 68 28 . . . cord-268388-kkhuzf3p 69 1 The the DT cord-268388-kkhuzf3p 69 2 exact exact JJ cord-268388-kkhuzf3p 69 3 mechanism mechanism NN cord-268388-kkhuzf3p 69 4 of of IN cord-268388-kkhuzf3p 69 5 entry entry NN cord-268388-kkhuzf3p 69 6 after after IN cord-268388-kkhuzf3p 69 7 receptor receptor NN cord-268388-kkhuzf3p 69 8 binding binding NN cord-268388-kkhuzf3p 69 9 is be VBZ cord-268388-kkhuzf3p 69 10 still still RB cord-268388-kkhuzf3p 69 11 unknown unknown JJ cord-268388-kkhuzf3p 69 12 . . . cord-268388-kkhuzf3p 70 1 The the DT cord-268388-kkhuzf3p 70 2 S S NNP cord-268388-kkhuzf3p 70 3 surface surface NN cord-268388-kkhuzf3p 70 4 protein protein NN cord-268388-kkhuzf3p 70 5 is be VBZ cord-268388-kkhuzf3p 70 6 composed compose VBN cord-268388-kkhuzf3p 70 7 of of IN cord-268388-kkhuzf3p 70 8 a a DT cord-268388-kkhuzf3p 70 9 core core NN cord-268388-kkhuzf3p 70 10 subdomain subdomain NN cord-268388-kkhuzf3p 70 11 that that WDT cord-268388-kkhuzf3p 70 12 shares share VBZ cord-268388-kkhuzf3p 70 13 similarity similarity NN cord-268388-kkhuzf3p 70 14 with with IN cord-268388-kkhuzf3p 70 15 that that DT cord-268388-kkhuzf3p 70 16 of of IN cord-268388-kkhuzf3p 70 17 SARS SARS NNP cord-268388-kkhuzf3p 70 18 - - HYPH cord-268388-kkhuzf3p 70 19 CoV CoV NNP cord-268388-kkhuzf3p 70 20 and and CC cord-268388-kkhuzf3p 70 21 a a DT cord-268388-kkhuzf3p 70 22 receptor receptor NN cord-268388-kkhuzf3p 70 23 binding bind VBG cord-268388-kkhuzf3p 70 24 subdomain subdomain NN cord-268388-kkhuzf3p 70 25 ( ( -LRB- cord-268388-kkhuzf3p 70 26 RBSD RBSD NNP cord-268388-kkhuzf3p 70 27 ) ) -RRB- cord-268388-kkhuzf3p 70 28 that that WDT cord-268388-kkhuzf3p 70 29 exhibits exhibit VBZ cord-268388-kkhuzf3p 70 30 significant significant JJ cord-268388-kkhuzf3p 70 31 variation variation NN cord-268388-kkhuzf3p 70 32 from from IN cord-268388-kkhuzf3p 70 33 the the DT cord-268388-kkhuzf3p 70 34 SARS SARS NNP cord-268388-kkhuzf3p 70 35 - - HYPH cord-268388-kkhuzf3p 70 36 CoV CoV NNP cord-268388-kkhuzf3p 70 37 RBSD RBSD NNP cord-268388-kkhuzf3p 70 38 . . . cord-268388-kkhuzf3p 71 1 The the DT cord-268388-kkhuzf3p 71 2 development development NN cord-268388-kkhuzf3p 71 3 of of IN cord-268388-kkhuzf3p 71 4 vaccines vaccine NNS cord-268388-kkhuzf3p 71 5 targeting target VBG cord-268388-kkhuzf3p 71 6 the the DT cord-268388-kkhuzf3p 71 7 RBSD RBSD NNP cord-268388-kkhuzf3p 71 8 of of IN cord-268388-kkhuzf3p 71 9 MERS MERS NNP cord-268388-kkhuzf3p 71 10 - - HYPH cord-268388-kkhuzf3p 71 11 CoV CoV NNP cord-268388-kkhuzf3p 71 12 is be VBZ cord-268388-kkhuzf3p 71 13 currently currently RB cord-268388-kkhuzf3p 71 14 under under IN cord-268388-kkhuzf3p 71 15 investigation investigation NN cord-268388-kkhuzf3p 71 16 because because IN cord-268388-kkhuzf3p 71 17 they -PRON- PRP cord-268388-kkhuzf3p 71 18 are be VBP cord-268388-kkhuzf3p 71 19 thought think VBN cord-268388-kkhuzf3p 71 20 to to TO cord-268388-kkhuzf3p 71 21 be be VB cord-268388-kkhuzf3p 71 22 safer safe JJR cord-268388-kkhuzf3p 71 23 and and CC cord-268388-kkhuzf3p 71 24 more more RBR cord-268388-kkhuzf3p 71 25 effective effective JJ cord-268388-kkhuzf3p 71 26 than than IN cord-268388-kkhuzf3p 71 27 vaccines vaccine NNS cord-268388-kkhuzf3p 71 28 based base VBN cord-268388-kkhuzf3p 71 29 on on IN cord-268388-kkhuzf3p 71 30 inactivated inactivate VBN cord-268388-kkhuzf3p 71 31 virus virus NN cord-268388-kkhuzf3p 71 32 , , , cord-268388-kkhuzf3p 71 33 DNA DNA NNP cord-268388-kkhuzf3p 71 34 , , , cord-268388-kkhuzf3p 71 35 or or CC cord-268388-kkhuzf3p 71 36 viral viral JJ cord-268388-kkhuzf3p 71 37 vectors vector NNS cord-268388-kkhuzf3p 71 38 [ [ -LRB- cord-268388-kkhuzf3p 71 39 40 40 CD cord-268388-kkhuzf3p 71 40 ] ] -RRB- cord-268388-kkhuzf3p 71 41 . . . cord-268388-kkhuzf3p 72 1 Another another DT cord-268388-kkhuzf3p 72 2 potential potential JJ cord-268388-kkhuzf3p 72 3 therapeutic therapeutic JJ cord-268388-kkhuzf3p 72 4 approach approach NN cord-268388-kkhuzf3p 72 5 is be VBZ cord-268388-kkhuzf3p 72 6 the the DT cord-268388-kkhuzf3p 72 7 inhibition inhibition NN cord-268388-kkhuzf3p 72 8 of of IN cord-268388-kkhuzf3p 72 9 the the DT cord-268388-kkhuzf3p 72 10 papain papain NN cord-268388-kkhuzf3p 72 11 - - HYPH cord-268388-kkhuzf3p 72 12 like like JJ cord-268388-kkhuzf3p 72 13 and/or and/or CC cord-268388-kkhuzf3p 72 14 3C 3c NN cord-268388-kkhuzf3p 72 15 - - HYPH cord-268388-kkhuzf3p 72 16 like like JJ cord-268388-kkhuzf3p 72 17 protease protease NN cord-268388-kkhuzf3p 72 18 of of IN cord-268388-kkhuzf3p 72 19 MERS MERS NNP cord-268388-kkhuzf3p 72 20 - - HYPH cord-268388-kkhuzf3p 72 21 CoV CoV NNP cord-268388-kkhuzf3p 72 22 [ [ -LRB- cord-268388-kkhuzf3p 72 23 41 41 CD cord-268388-kkhuzf3p 72 24 ] ] -RRB- cord-268388-kkhuzf3p 72 25 . . . cord-268388-kkhuzf3p 73 1 To to IN cord-268388-kkhuzf3p 73 2 date date NN cord-268388-kkhuzf3p 73 3 , , , cord-268388-kkhuzf3p 73 4 no no DT cord-268388-kkhuzf3p 73 5 effective effective JJ cord-268388-kkhuzf3p 73 6 therapy therapy NN cord-268388-kkhuzf3p 73 7 or or CC cord-268388-kkhuzf3p 73 8 prophylaxis prophylaxis NN cord-268388-kkhuzf3p 73 9 for for IN cord-268388-kkhuzf3p 73 10 MERS MERS NNP cord-268388-kkhuzf3p 73 11 - - HYPH cord-268388-kkhuzf3p 73 12 CoV CoV NNP cord-268388-kkhuzf3p 73 13 exists exist VBZ cord-268388-kkhuzf3p 73 14 . . . cord-268388-kkhuzf3p 74 1 Supportive supportive JJ cord-268388-kkhuzf3p 74 2 therapy therapy NN cord-268388-kkhuzf3p 74 3 remains remain VBZ cord-268388-kkhuzf3p 74 4 the the DT cord-268388-kkhuzf3p 74 5 cornerstone cornerstone NN cord-268388-kkhuzf3p 74 6 of of IN cord-268388-kkhuzf3p 74 7 management management NN cord-268388-kkhuzf3p 74 8 . . . cord-268388-kkhuzf3p 75 1 Current current JJ cord-268388-kkhuzf3p 75 2 treatment treatment NN cord-268388-kkhuzf3p 75 3 is be VBZ cord-268388-kkhuzf3p 75 4 based base VBN cord-268388-kkhuzf3p 75 5 on on IN cord-268388-kkhuzf3p 75 6 previous previous JJ cord-268388-kkhuzf3p 75 7 experience experience NN cord-268388-kkhuzf3p 75 8 with with IN cord-268388-kkhuzf3p 75 9 the the DT cord-268388-kkhuzf3p 75 10 SARS SARS NNP cord-268388-kkhuzf3p 75 11 - - HYPH cord-268388-kkhuzf3p 75 12 CoV CoV NNP cord-268388-kkhuzf3p 75 13 , , , cord-268388-kkhuzf3p 75 14 in in IN cord-268388-kkhuzf3p 75 15 - - HYPH cord-268388-kkhuzf3p 75 16 vitro vitro FW cord-268388-kkhuzf3p 75 17 studies study NNS cord-268388-kkhuzf3p 75 18 , , , cord-268388-kkhuzf3p 75 19 and and CC cord-268388-kkhuzf3p 75 20 case case NN cord-268388-kkhuzf3p 75 21 series series NN cord-268388-kkhuzf3p 75 22 . . . cord-268388-kkhuzf3p 76 1 Various various JJ cord-268388-kkhuzf3p 76 2 agents agent NNS cord-268388-kkhuzf3p 76 3 have have VBP cord-268388-kkhuzf3p 76 4 been be VBN cord-268388-kkhuzf3p 76 5 tried try VBN cord-268388-kkhuzf3p 76 6 , , , cord-268388-kkhuzf3p 76 7 including include VBG cord-268388-kkhuzf3p 76 8 those those DT cord-268388-kkhuzf3p 76 9 that that WDT cord-268388-kkhuzf3p 76 10 block block NN cord-268388-kkhuzf3p 76 11 virus virus NN cord-268388-kkhuzf3p 76 12 entry entry NN cord-268388-kkhuzf3p 76 13 , , , cord-268388-kkhuzf3p 76 14 inhibit inhibit VB cord-268388-kkhuzf3p 76 15 viral viral JJ cord-268388-kkhuzf3p 76 16 replication replication NN cord-268388-kkhuzf3p 76 17 , , , cord-268388-kkhuzf3p 76 18 or or CC cord-268388-kkhuzf3p 76 19 interfere interfere VB cord-268388-kkhuzf3p 76 20 with with IN cord-268388-kkhuzf3p 76 21 host host NN cord-268388-kkhuzf3p 76 22 immune immune JJ cord-268388-kkhuzf3p 76 23 response response NN cord-268388-kkhuzf3p 76 24 [ [ -LRB- cord-268388-kkhuzf3p 76 25 42 42 CD cord-268388-kkhuzf3p 76 26 ] ] -RRB- cord-268388-kkhuzf3p 76 27 . . . cord-268388-kkhuzf3p 77 1 The the DT cord-268388-kkhuzf3p 77 2 International International NNP cord-268388-kkhuzf3p 77 3 Severe Severe NNP cord-268388-kkhuzf3p 77 4 Acute Acute NNP cord-268388-kkhuzf3p 77 5 Respiratory Respiratory NNP cord-268388-kkhuzf3p 77 6 and and CC cord-268388-kkhuzf3p 77 7 Emerging Emerging NNP cord-268388-kkhuzf3p 77 8 Infection Infection NNP cord-268388-kkhuzf3p 77 9 Consortium Consortium NNP cord-268388-kkhuzf3p 77 10 ( ( -LRB- cord-268388-kkhuzf3p 77 11 ISARIC ISARIC NNP cord-268388-kkhuzf3p 77 12 ) ) -RRB- cord-268388-kkhuzf3p 77 13 suggested suggest VBD cord-268388-kkhuzf3p 77 14 therapeutic therapeutic JJ cord-268388-kkhuzf3p 77 15 options option NNS cord-268388-kkhuzf3p 77 16 for for IN cord-268388-kkhuzf3p 77 17 treatment treatment NN cord-268388-kkhuzf3p 77 18 of of IN cord-268388-kkhuzf3p 77 19 MERS MERS NNP cord-268388-kkhuzf3p 77 20 - - HYPH cord-268388-kkhuzf3p 77 21 CoV cov NN cord-268388-kkhuzf3p 77 22 infection infection NN cord-268388-kkhuzf3p 77 23 with with IN cord-268388-kkhuzf3p 77 24 various various JJ cord-268388-kkhuzf3p 77 25 agents agent NNS cord-268388-kkhuzf3p 77 26 alongside alongside IN cord-268388-kkhuzf3p 77 27 continuous continuous JJ cord-268388-kkhuzf3p 77 28 evaluation evaluation NN cord-268388-kkhuzf3p 77 29 of of IN cord-268388-kkhuzf3p 77 30 efficacy efficacy NN cord-268388-kkhuzf3p 77 31 , , , cord-268388-kkhuzf3p 77 32 and and CC cord-268388-kkhuzf3p 77 33 in in IN cord-268388-kkhuzf3p 77 34 the the DT cord-268388-kkhuzf3p 77 35 setting setting NN cord-268388-kkhuzf3p 77 36 of of IN cord-268388-kkhuzf3p 77 37 clinical clinical JJ cord-268388-kkhuzf3p 77 38 trials trial NNS cord-268388-kkhuzf3p 77 39 [ [ -LRB- cord-268388-kkhuzf3p 77 40 43 43 CD cord-268388-kkhuzf3p 77 41 ] ] -RRB- cord-268388-kkhuzf3p 77 42 . . . cord-268388-kkhuzf3p 78 1 Based base VBN cord-268388-kkhuzf3p 78 2 on on IN cord-268388-kkhuzf3p 78 3 experience experience NN cord-268388-kkhuzf3p 78 4 with with IN cord-268388-kkhuzf3p 78 5 SARS SARS NNP cord-268388-kkhuzf3p 78 6 - - HYPH cord-268388-kkhuzf3p 78 7 CoV CoV NNP cord-268388-kkhuzf3p 78 8 , , , cord-268388-kkhuzf3p 78 9 the the DT cord-268388-kkhuzf3p 78 10 use use NN cord-268388-kkhuzf3p 78 11 of of IN cord-268388-kkhuzf3p 78 12 convalescent convalescent JJ cord-268388-kkhuzf3p 78 13 plasma plasma NN cord-268388-kkhuzf3p 78 14 , , , cord-268388-kkhuzf3p 78 15 hyper hyper JJ cord-268388-kkhuzf3p 78 16 - - JJ cord-268388-kkhuzf3p 78 17 immune immune JJ cord-268388-kkhuzf3p 78 18 globulin globulin NN cord-268388-kkhuzf3p 78 19 , , , cord-268388-kkhuzf3p 78 20 or or CC cord-268388-kkhuzf3p 78 21 human human JJ cord-268388-kkhuzf3p 78 22 monoclonal monoclonal JJ cord-268388-kkhuzf3p 78 23 antibodies antibody NNS cord-268388-kkhuzf3p 78 24 that that WDT cord-268388-kkhuzf3p 78 25 contain contain VBP cord-268388-kkhuzf3p 78 26 neutralizing neutralize VBG cord-268388-kkhuzf3p 78 27 antibodies antibody NNS cord-268388-kkhuzf3p 78 28 may may MD cord-268388-kkhuzf3p 78 29 be be VB cord-268388-kkhuzf3p 78 30 efficacious efficacious JJ cord-268388-kkhuzf3p 78 31 and and CC cord-268388-kkhuzf3p 78 32 is be VBZ cord-268388-kkhuzf3p 78 33 recommended recommend VBN cord-268388-kkhuzf3p 78 34 as as IN cord-268388-kkhuzf3p 78 35 first first JJ cord-268388-kkhuzf3p 78 36 - - HYPH cord-268388-kkhuzf3p 78 37 line line NN cord-268388-kkhuzf3p 78 38 treatment treatment NN cord-268388-kkhuzf3p 78 39 when when WRB cord-268388-kkhuzf3p 78 40 available available JJ cord-268388-kkhuzf3p 78 41 [ [ -LRB- cord-268388-kkhuzf3p 78 42 43 43 CD cord-268388-kkhuzf3p 78 43 ] ] -RRB- cord-268388-kkhuzf3p 78 44 . . . cord-268388-kkhuzf3p 79 1 Ribavirin ribavirin RB cord-268388-kkhuzf3p 79 2 and and CC cord-268388-kkhuzf3p 79 3 interferon interferon NN cord-268388-kkhuzf3p 79 4 alpha-2b alpha-2b NNP cord-268388-kkhuzf3p 79 5 both both DT cord-268388-kkhuzf3p 79 6 showed show VBD cord-268388-kkhuzf3p 79 7 promising promising JJ cord-268388-kkhuzf3p 79 8 results result NNS cord-268388-kkhuzf3p 79 9 , , , cord-268388-kkhuzf3p 79 10 especially especially RB cord-268388-kkhuzf3p 79 11 when when WRB cord-268388-kkhuzf3p 79 12 used use VBN cord-268388-kkhuzf3p 79 13 in in IN cord-268388-kkhuzf3p 79 14 combination combination NN cord-268388-kkhuzf3p 79 15 , , , cord-268388-kkhuzf3p 79 16 both both DT cord-268388-kkhuzf3p 79 17 in in IN cord-268388-kkhuzf3p 79 18 vitro vitro FW cord-268388-kkhuzf3p 79 19 and and CC cord-268388-kkhuzf3p 79 20 in in IN cord-268388-kkhuzf3p 79 21 animal animal NN cord-268388-kkhuzf3p 79 22 studies study NNS cord-268388-kkhuzf3p 79 23 using use VBG cord-268388-kkhuzf3p 79 24 rhesus rhesu NNS cord-268388-kkhuzf3p 79 25 macaques macaque NNS cord-268388-kkhuzf3p 79 26 monkeys monkey NNS cord-268388-kkhuzf3p 79 27 [ [ -LRB- cord-268388-kkhuzf3p 79 28 44 44 CD cord-268388-kkhuzf3p 79 29 ] ] -RRB- cord-268388-kkhuzf3p 79 30 . . . cord-268388-kkhuzf3p 80 1 However however RB cord-268388-kkhuzf3p 80 2 , , , cord-268388-kkhuzf3p 80 3 these these DT cord-268388-kkhuzf3p 80 4 positive positive JJ cord-268388-kkhuzf3p 80 5 results result NNS cord-268388-kkhuzf3p 80 6 did do VBD cord-268388-kkhuzf3p 80 7 not not RB cord-268388-kkhuzf3p 80 8 translate translate VB cord-268388-kkhuzf3p 80 9 clinically clinically RB cord-268388-kkhuzf3p 80 10 in in IN cord-268388-kkhuzf3p 80 11 an an DT cord-268388-kkhuzf3p 80 12 observational observational JJ cord-268388-kkhuzf3p 80 13 study study NN cord-268388-kkhuzf3p 80 14 in in IN cord-268388-kkhuzf3p 80 15 five five CD cord-268388-kkhuzf3p 80 16 patients patient NNS cord-268388-kkhuzf3p 80 17 , , , cord-268388-kkhuzf3p 80 18 all all DT cord-268388-kkhuzf3p 80 19 of of IN cord-268388-kkhuzf3p 80 20 whom whom WP cord-268388-kkhuzf3p 80 21 succumbed succumb VBD cord-268388-kkhuzf3p 80 22 to to IN cord-268388-kkhuzf3p 80 23 the the DT cord-268388-kkhuzf3p 80 24 infection infection NN cord-268388-kkhuzf3p 80 25 [ [ -LRB- cord-268388-kkhuzf3p 80 26 45 45 CD cord-268388-kkhuzf3p 80 27 , , , cord-268388-kkhuzf3p 80 28 46 46 CD cord-268388-kkhuzf3p 80 29 ] ] -RRB- cord-268388-kkhuzf3p 80 30 . . . cord-268388-kkhuzf3p 81 1 Repurposing repurpose VBG cord-268388-kkhuzf3p 81 2 of of IN cord-268388-kkhuzf3p 81 3 currently currently RB cord-268388-kkhuzf3p 81 4 available available JJ cord-268388-kkhuzf3p 81 5 agents agent NNS cord-268388-kkhuzf3p 81 6 may may MD cord-268388-kkhuzf3p 81 7 be be VB cord-268388-kkhuzf3p 81 8 an an DT cord-268388-kkhuzf3p 81 9 efficient efficient JJ cord-268388-kkhuzf3p 81 10 approach approach NN cord-268388-kkhuzf3p 81 11 . . . cord-268388-kkhuzf3p 82 1 Dyall Dyall NNP cord-268388-kkhuzf3p 82 2 et et FW cord-268388-kkhuzf3p 82 3 al al NNP cord-268388-kkhuzf3p 82 4 . . . cord-268388-kkhuzf3p 83 1 screened screen VBD cord-268388-kkhuzf3p 83 2 various various JJ cord-268388-kkhuzf3p 83 3 agents agent NNS cord-268388-kkhuzf3p 83 4 with with IN cord-268388-kkhuzf3p 83 5 potential potential JJ cord-268388-kkhuzf3p 83 6 therapeutic therapeutic JJ cord-268388-kkhuzf3p 83 7 efficacy efficacy NN cord-268388-kkhuzf3p 83 8 [ [ -LRB- cord-268388-kkhuzf3p 83 9 46 46 CD cord-268388-kkhuzf3p 83 10 ] ] -RRB- cord-268388-kkhuzf3p 83 11 . . . cord-268388-kkhuzf3p 84 1 Cyclosporin Cyclosporin NNP cord-268388-kkhuzf3p 84 2 A A NNP cord-268388-kkhuzf3p 84 3 , , , cord-268388-kkhuzf3p 84 4 mycophenolic mycophenolic JJ cord-268388-kkhuzf3p 84 5 acid acid NN cord-268388-kkhuzf3p 84 6 , , , cord-268388-kkhuzf3p 84 7 interferon interferon NN cord-268388-kkhuzf3p 84 8 - - HYPH cord-268388-kkhuzf3p 84 9 beta beta NN cord-268388-kkhuzf3p 84 10 , , , cord-268388-kkhuzf3p 84 11 homoharringtonine homoharringtonine NNP cord-268388-kkhuzf3p 84 12 , , , cord-268388-kkhuzf3p 84 13 cycloheximide cycloheximide NN cord-268388-kkhuzf3p 84 14 , , , cord-268388-kkhuzf3p 84 15 anisomycin anisomycin NNP cord-268388-kkhuzf3p 84 16 , , , cord-268388-kkhuzf3p 84 17 and and CC cord-268388-kkhuzf3p 84 18 emetine emetine NNP cord-268388-kkhuzf3p 84 19 dihydrochloride dihydrochloride NNP cord-268388-kkhuzf3p 84 20 hydrate hydrate VB cord-268388-kkhuzf3p 84 21 were be VBD cord-268388-kkhuzf3p 84 22 found find VBN cord-268388-kkhuzf3p 84 23 to to TO cord-268388-kkhuzf3p 84 24 have have VB cord-268388-kkhuzf3p 84 25 the the DT cord-268388-kkhuzf3p 84 26 most most RBS cord-268388-kkhuzf3p 84 27 potent potent JJ cord-268388-kkhuzf3p 84 28 in in IN cord-268388-kkhuzf3p 84 29 vitro vitro FW cord-268388-kkhuzf3p 84 30 activity activity NN cord-268388-kkhuzf3p 84 31 against against IN cord-268388-kkhuzf3p 84 32 MERS MERS NNP cord-268388-kkhuzf3p 85 1 -CoV. -cov. ADD cord-268388-kkhuzf3p 86 1 Despite despite IN cord-268388-kkhuzf3p 86 2 the the DT cord-268388-kkhuzf3p 86 3 progress progress NN cord-268388-kkhuzf3p 86 4 in in IN cord-268388-kkhuzf3p 86 5 our -PRON- PRP$ cord-268388-kkhuzf3p 86 6 understanding understanding NN cord-268388-kkhuzf3p 86 7 of of IN cord-268388-kkhuzf3p 86 8 MERS MERS NNP cord-268388-kkhuzf3p 86 9 - - HYPH cord-268388-kkhuzf3p 86 10 CoV CoV NNP cord-268388-kkhuzf3p 86 11 , , , cord-268388-kkhuzf3p 86 12 many many JJ cord-268388-kkhuzf3p 86 13 questions question NNS cord-268388-kkhuzf3p 86 14 remain remain VBP cord-268388-kkhuzf3p 86 15 unanswered unanswered JJ cord-268388-kkhuzf3p 86 16 . . . cord-268388-kkhuzf3p 87 1 The the DT cord-268388-kkhuzf3p 87 2 definitive definitive JJ cord-268388-kkhuzf3p 87 3 origin origin NN cord-268388-kkhuzf3p 87 4 , , , cord-268388-kkhuzf3p 87 5 exact exact JJ cord-268388-kkhuzf3p 87 6 mechanism mechanism NN cord-268388-kkhuzf3p 87 7 of of IN cord-268388-kkhuzf3p 87 8 transmission transmission NN cord-268388-kkhuzf3p 87 9 , , , cord-268388-kkhuzf3p 87 10 and and CC cord-268388-kkhuzf3p 87 11 the the DT cord-268388-kkhuzf3p 87 12 reason reason NN cord-268388-kkhuzf3p 87 13 behind behind IN cord-268388-kkhuzf3p 87 14 seasonal seasonal JJ cord-268388-kkhuzf3p 87 15 variability variability NN cord-268388-kkhuzf3p 87 16 are be VBP cord-268388-kkhuzf3p 87 17 still still RB cord-268388-kkhuzf3p 87 18 unclear unclear JJ cord-268388-kkhuzf3p 87 19 . . . cord-268388-kkhuzf3p 88 1 Although although IN cord-268388-kkhuzf3p 88 2 most most JJS cord-268388-kkhuzf3p 88 3 cases case NNS cord-268388-kkhuzf3p 88 4 have have VBP cord-268388-kkhuzf3p 88 5 been be VBN cord-268388-kkhuzf3p 88 6 described describe VBN cord-268388-kkhuzf3p 88 7 in in IN cord-268388-kkhuzf3p 88 8 countries country NNS cord-268388-kkhuzf3p 88 9 of of IN cord-268388-kkhuzf3p 88 10 the the DT cord-268388-kkhuzf3p 88 11 Arabian Arabian NNP cord-268388-kkhuzf3p 88 12 Peninsula Peninsula NNP cord-268388-kkhuzf3p 88 13 , , , cord-268388-kkhuzf3p 88 14 the the DT cord-268388-kkhuzf3p 88 15 increasing increase VBG cord-268388-kkhuzf3p 88 16 travel travel NN cord-268388-kkhuzf3p 88 17 to to IN cord-268388-kkhuzf3p 88 18 the the DT cord-268388-kkhuzf3p 88 19 region region NN cord-268388-kkhuzf3p 88 20 and and CC cord-268388-kkhuzf3p 88 21 the the DT cord-268388-kkhuzf3p 88 22 Hajj Hajj NNP cord-268388-kkhuzf3p 88 23 season season NN cord-268388-kkhuzf3p 88 24 in in IN cord-268388-kkhuzf3p 88 25 KSA KSA NNP cord-268388-kkhuzf3p 88 26 pose pose VBP cord-268388-kkhuzf3p 88 27 a a DT cord-268388-kkhuzf3p 88 28 threat threat NN cord-268388-kkhuzf3p 88 29 of of IN cord-268388-kkhuzf3p 88 30 a a DT cord-268388-kkhuzf3p 88 31 potential potential JJ cord-268388-kkhuzf3p 88 32 global global JJ cord-268388-kkhuzf3p 88 33 pandemic pandemic NN cord-268388-kkhuzf3p 88 34 . . . cord-268388-kkhuzf3p 89 1 Extensive extensive JJ cord-268388-kkhuzf3p 89 2 efforts effort NNS cord-268388-kkhuzf3p 89 3 are be VBP cord-268388-kkhuzf3p 89 4 required require VBN cord-268388-kkhuzf3p 89 5 to to TO cord-268388-kkhuzf3p 89 6 speed speed VB cord-268388-kkhuzf3p 89 7 up up RP cord-268388-kkhuzf3p 89 8 the the DT cord-268388-kkhuzf3p 89 9 development development NN cord-268388-kkhuzf3p 89 10 of of IN cord-268388-kkhuzf3p 89 11 an an DT cord-268388-kkhuzf3p 89 12 effective effective JJ cord-268388-kkhuzf3p 89 13 therapy therapy NN cord-268388-kkhuzf3p 89 14 and and CC cord-268388-kkhuzf3p 89 15 vaccine vaccine NN cord-268388-kkhuzf3p 89 16 . . . cord-268388-kkhuzf3p 90 1 Repurposing repurpose VBG cord-268388-kkhuzf3p 90 2 of of IN cord-268388-kkhuzf3p 90 3 currently currently RB cord-268388-kkhuzf3p 90 4 available available JJ cord-268388-kkhuzf3p 90 5 pharmaceutical pharmaceutical JJ cord-268388-kkhuzf3p 90 6 agents agent NNS cord-268388-kkhuzf3p 90 7 is be VBZ cord-268388-kkhuzf3p 90 8 highly highly RB cord-268388-kkhuzf3p 90 9 desirable desirable JJ cord-268388-kkhuzf3p 90 10 for for IN cord-268388-kkhuzf3p 90 11 a a DT cord-268388-kkhuzf3p 90 12 more more RBR cord-268388-kkhuzf3p 90 13 rapid rapid JJ cord-268388-kkhuzf3p 90 14 drug drug NN cord-268388-kkhuzf3p 90 15 development development NN cord-268388-kkhuzf3p 90 16 . . . cord-268388-kkhuzf3p 91 1 Meanwhile meanwhile RB cord-268388-kkhuzf3p 91 2 , , , cord-268388-kkhuzf3p 91 3 HCWs HCWs NNPS cord-268388-kkhuzf3p 91 4 who who WP cord-268388-kkhuzf3p 91 5 encounter encounter VBP cord-268388-kkhuzf3p 91 6 patients patient NNS cord-268388-kkhuzf3p 91 7 with with IN cord-268388-kkhuzf3p 91 8 respiratory respiratory JJ cord-268388-kkhuzf3p 91 9 symptoms symptom NNS cord-268388-kkhuzf3p 91 10 who who WP cord-268388-kkhuzf3p 91 11 have have VBP cord-268388-kkhuzf3p 91 12 lived live VBN cord-268388-kkhuzf3p 91 13 or or CC cord-268388-kkhuzf3p 91 14 traveled travel VBN cord-268388-kkhuzf3p 91 15 to to IN cord-268388-kkhuzf3p 91 16 areas area NNS cord-268388-kkhuzf3p 91 17 with with IN cord-268388-kkhuzf3p 91 18 MERS MERS NNP cord-268388-kkhuzf3p 91 19 - - HYPH cord-268388-kkhuzf3p 91 20 CoV CoV NNP cord-268388-kkhuzf3p 91 21 should should MD cord-268388-kkhuzf3p 91 22 have have VB cord-268388-kkhuzf3p 91 23 a a DT cord-268388-kkhuzf3p 91 24 low low JJ cord-268388-kkhuzf3p 91 25 threshold threshold NN cord-268388-kkhuzf3p 91 26 to to TO cord-268388-kkhuzf3p 91 27 consider consider VB cord-268388-kkhuzf3p 91 28 a a DT cord-268388-kkhuzf3p 91 29 diagnosis diagnosis NN cord-268388-kkhuzf3p 91 30 of of IN cord-268388-kkhuzf3p 91 31 MERS MERS NNP cord-268388-kkhuzf3p 91 32 - - HYPH cord-268388-kkhuzf3p 91 33 CoV CoV NNP cord-268388-kkhuzf3p 91 34 , , , cord-268388-kkhuzf3p 91 35 with with IN cord-268388-kkhuzf3p 91 36 testing testing NN cord-268388-kkhuzf3p 91 37 and and CC cord-268388-kkhuzf3p 91 38 immediate immediate JJ cord-268388-kkhuzf3p 91 39 implementation implementation NN cord-268388-kkhuzf3p 91 40 of of IN cord-268388-kkhuzf3p 91 41 proper proper JJ cord-268388-kkhuzf3p 91 42 infection infection NN cord-268388-kkhuzf3p 91 43 control control NN cord-268388-kkhuzf3p 91 44 practices practice NNS cord-268388-kkhuzf3p 91 45 to to TO cord-268388-kkhuzf3p 91 46 prevent prevent VB cord-268388-kkhuzf3p 91 47 further further JJ cord-268388-kkhuzf3p 91 48 spread spread NN cord-268388-kkhuzf3p 91 49 . . . cord-268388-kkhuzf3p 92 1 Finally finally RB cord-268388-kkhuzf3p 92 2 , , , cord-268388-kkhuzf3p 92 3 given give VBN cord-268388-kkhuzf3p 92 4 the the DT cord-268388-kkhuzf3p 92 5 important important JJ cord-268388-kkhuzf3p 92 6 role role NN cord-268388-kkhuzf3p 92 7 that that WDT cord-268388-kkhuzf3p 92 8 camels camel NNS cord-268388-kkhuzf3p 92 9 may may MD cord-268388-kkhuzf3p 92 10 play play VB cord-268388-kkhuzf3p 92 11 in in IN cord-268388-kkhuzf3p 92 12 transmission transmission NN cord-268388-kkhuzf3p 92 13 of of IN cord-268388-kkhuzf3p 92 14 the the DT cord-268388-kkhuzf3p 92 15 virus virus NN cord-268388-kkhuzf3p 92 16 , , , cord-268388-kkhuzf3p 92 17 the the DT cord-268388-kkhuzf3p 92 18 common common JJ cord-268388-kkhuzf3p 92 19 practices practice NNS cord-268388-kkhuzf3p 92 20 in in IN cord-268388-kkhuzf3p 92 21 the the DT cord-268388-kkhuzf3p 92 22 Arabian Arabian NNP cord-268388-kkhuzf3p 92 23 Peninsula Peninsula NNP cord-268388-kkhuzf3p 92 24 of of IN cord-268388-kkhuzf3p 92 25 herding herd VBG cord-268388-kkhuzf3p 92 26 and and CC cord-268388-kkhuzf3p 92 27 consuming consume VBG cord-268388-kkhuzf3p 92 28 unpasteurized unpasteurized JJ cord-268388-kkhuzf3p 92 29 camels camel NNS cord-268388-kkhuzf3p 92 30 ' ' POS cord-268388-kkhuzf3p 92 31 milk milk NN cord-268388-kkhuzf3p 92 32 should should MD cord-268388-kkhuzf3p 92 33 be be VB cord-268388-kkhuzf3p 92 34 discouraged discourage VBN cord-268388-kkhuzf3p 92 35 until until IN cord-268388-kkhuzf3p 92 36 conclusive conclusive JJ cord-268388-kkhuzf3p 92 37 evidence evidence NN cord-268388-kkhuzf3p 92 38 is be VBZ cord-268388-kkhuzf3p 92 39 obtained obtain VBN cord-268388-kkhuzf3p 92 40 that that IN cord-268388-kkhuzf3p 92 41 such such JJ cord-268388-kkhuzf3p 92 42 practices practice NNS cord-268388-kkhuzf3p 92 43 do do VBP cord-268388-kkhuzf3p 92 44 not not RB cord-268388-kkhuzf3p 92 45 contribute contribute VB cord-268388-kkhuzf3p 92 46 to to IN cord-268388-kkhuzf3p 92 47 infection infection NN cord-268388-kkhuzf3p 92 48 . . . cord-268388-kkhuzf3p 93 1 Isolation isolation NN cord-268388-kkhuzf3p 93 2 of of IN cord-268388-kkhuzf3p 93 3 a a DT cord-268388-kkhuzf3p 93 4 novel novel JJ cord-268388-kkhuzf3p 93 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 93 6 from from IN cord-268388-kkhuzf3p 93 7 a a DT cord-268388-kkhuzf3p 93 8 man man NN cord-268388-kkhuzf3p 93 9 with with IN cord-268388-kkhuzf3p 93 10 pneumonia pneumonia NN cord-268388-kkhuzf3p 93 11 in in IN cord-268388-kkhuzf3p 93 12 saudi saudi NNP cord-268388-kkhuzf3p 93 13 arabia arabia NNP cord-268388-kkhuzf3p 93 14 MERS MERS NNP cord-268388-kkhuzf3p 93 15 : : : cord-268388-kkhuzf3p 94 1 Emergence emergence NN cord-268388-kkhuzf3p 94 2 of of IN cord-268388-kkhuzf3p 94 3 a a DT cord-268388-kkhuzf3p 94 4 novel novel JJ cord-268388-kkhuzf3p 94 5 human human JJ cord-268388-kkhuzf3p 94 6 coronavirus coronavirus NN cord-268388-kkhuzf3p 94 7 Middle Middle NNP cord-268388-kkhuzf3p 94 8 East East NNP cord-268388-kkhuzf3p 94 9 respiratory respiratory JJ cord-268388-kkhuzf3p 94 10 syndrome syndrome NN cord-268388-kkhuzf3p 94 11 coronavirus coronavirus NN cord-268388-kkhuzf3p 94 12 ( ( -LRB- cord-268388-kkhuzf3p 94 13 MERS MERS NNP cord-268388-kkhuzf3p 94 14 - - HYPH cord-268388-kkhuzf3p 94 15 CoV CoV NNP cord-268388-kkhuzf3p 94 16 ) ) -RRB- cord-268388-kkhuzf3p 94 17 summary summary NN cord-268388-kkhuzf3p 94 18 and and CC cord-268388-kkhuzf3p 94 19 literature literature NN cord-268388-kkhuzf3p 94 20 update update NN cord-268388-kkhuzf3p 94 21 as as IN cord-268388-kkhuzf3p 94 22 of of IN cord-268388-kkhuzf3p 94 23 26 26 CD cord-268388-kkhuzf3p 94 24 Identification identification NN cord-268388-kkhuzf3p 94 25 of of IN cord-268388-kkhuzf3p 94 26 a a DT cord-268388-kkhuzf3p 94 27 novel novel JJ cord-268388-kkhuzf3p 94 28 coronavirus coronavirus NN cord-268388-kkhuzf3p 94 29 in in IN cord-268388-kkhuzf3p 94 30 patients patient NNS cord-268388-kkhuzf3p 94 31 with with IN cord-268388-kkhuzf3p 94 32 severe severe JJ cord-268388-kkhuzf3p 94 33 acute acute JJ cord-268388-kkhuzf3p 94 34 respiratory respiratory JJ cord-268388-kkhuzf3p 94 35 syndrome syndrome NN cord-268388-kkhuzf3p 94 36 Consensus Consensus NNP cord-268388-kkhuzf3p 94 37 document document NN cord-268388-kkhuzf3p 94 38 on on IN cord-268388-kkhuzf3p 94 39 the the DT cord-268388-kkhuzf3p 94 40 epidemiology epidemiology NN cord-268388-kkhuzf3p 94 41 of of IN cord-268388-kkhuzf3p 94 42 severe severe JJ cord-268388-kkhuzf3p 94 43 acute acute JJ cord-268388-kkhuzf3p 94 44 respiratory respiratory JJ cord-268388-kkhuzf3p 94 45 syndrome syndrome NN cord-268388-kkhuzf3p 94 46 ( ( -LRB- cord-268388-kkhuzf3p 94 47 SARS SARS NNP cord-268388-kkhuzf3p 94 48 ) ) -RRB- cord-268388-kkhuzf3p 95 1 Genomic genomic JJ cord-268388-kkhuzf3p 95 2 characterization characterization NN cord-268388-kkhuzf3p 95 3 of of IN cord-268388-kkhuzf3p 95 4 a a DT cord-268388-kkhuzf3p 95 5 newly newly RB cord-268388-kkhuzf3p 95 6 discovered discover VBN cord-268388-kkhuzf3p 95 7 coronavirus coronavirus NN cord-268388-kkhuzf3p 95 8 associated associate VBN cord-268388-kkhuzf3p 95 9 with with IN cord-268388-kkhuzf3p 95 10 acute acute JJ cord-268388-kkhuzf3p 95 11 respiratory respiratory JJ cord-268388-kkhuzf3p 95 12 distress distress NN cord-268388-kkhuzf3p 95 13 syndrome syndrome NN cord-268388-kkhuzf3p 95 14 in in IN cord-268388-kkhuzf3p 96 1 humans human NNS cord-268388-kkhuzf3p 96 2 Dipeptidyl Dipeptidyl NNP cord-268388-kkhuzf3p 96 3 peptidase peptidase NN cord-268388-kkhuzf3p 96 4 4 4 CD cord-268388-kkhuzf3p 96 5 is be VBZ cord-268388-kkhuzf3p 96 6 a a DT cord-268388-kkhuzf3p 96 7 functional functional JJ cord-268388-kkhuzf3p 96 8 receptor receptor NN cord-268388-kkhuzf3p 96 9 for for IN cord-268388-kkhuzf3p 96 10 the the DT cord-268388-kkhuzf3p 96 11 emerging emerge VBG cord-268388-kkhuzf3p 96 12 human human JJ cord-268388-kkhuzf3p 96 13 coronavirus coronavirus NN cord-268388-kkhuzf3p 96 14 - - HYPH cord-268388-kkhuzf3p 96 15 EMC EMC NNP cord-268388-kkhuzf3p 96 16 Antibodies Antibodies NNP cord-268388-kkhuzf3p 96 17 against against IN cord-268388-kkhuzf3p 96 18 MERS MERS NNP cord-268388-kkhuzf3p 96 19 coronavirus coronavirus NN cord-268388-kkhuzf3p 96 20 in in IN cord-268388-kkhuzf3p 96 21 dromedary dromedary NN cord-268388-kkhuzf3p 96 22 camels camel NNS cord-268388-kkhuzf3p 97 1 Replicative replicative JJ cord-268388-kkhuzf3p 97 2 capacity capacity NN cord-268388-kkhuzf3p 97 3 of of IN cord-268388-kkhuzf3p 97 4 MERS MERS NNP cord-268388-kkhuzf3p 97 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 97 6 in in IN cord-268388-kkhuzf3p 97 7 livestock livestock NN cord-268388-kkhuzf3p 97 8 cell cell NN cord-268388-kkhuzf3p 97 9 lines line NNS cord-268388-kkhuzf3p 97 10 Middle Middle NNP cord-268388-kkhuzf3p 97 11 east east NNP cord-268388-kkhuzf3p 97 12 respiratory respiratory JJ cord-268388-kkhuzf3p 97 13 syndrome syndrome NN cord-268388-kkhuzf3p 97 14 coronavirus coronavirus NN cord-268388-kkhuzf3p 97 15 neutralising neutralise VBG cord-268388-kkhuzf3p 97 16 serum serum NN cord-268388-kkhuzf3p 97 17 antibodies antibody NNS cord-268388-kkhuzf3p 97 18 in in IN cord-268388-kkhuzf3p 97 19 dromedary dromedary NN cord-268388-kkhuzf3p 97 20 camels camel NNS cord-268388-kkhuzf3p 97 21 : : : cord-268388-kkhuzf3p 98 1 A a DT cord-268388-kkhuzf3p 98 2 comparative comparative JJ cord-268388-kkhuzf3p 98 3 serological serological JJ cord-268388-kkhuzf3p 98 4 study study NN cord-268388-kkhuzf3p 99 1 The the DT cord-268388-kkhuzf3p 99 2 emergence emergence NN cord-268388-kkhuzf3p 99 3 of of IN cord-268388-kkhuzf3p 99 4 the the DT cord-268388-kkhuzf3p 99 5 Middle Middle NNP cord-268388-kkhuzf3p 99 6 East East NNP cord-268388-kkhuzf3p 99 7 respiratory respiratory JJ cord-268388-kkhuzf3p 99 8 syndrome syndrome NN cord-268388-kkhuzf3p 99 9 coronavirus coronavirus NN cord-268388-kkhuzf3p 99 10 ( ( -LRB- cord-268388-kkhuzf3p 99 11 MERS MERS NNP cord-268388-kkhuzf3p 99 12 - - HYPH cord-268388-kkhuzf3p 99 13 CoV CoV NNP cord-268388-kkhuzf3p 99 14 ) ) -RRB- cord-268388-kkhuzf3p 100 1 Middle Middle NNP cord-268388-kkhuzf3p 100 2 east east NNP cord-268388-kkhuzf3p 100 3 respiratory respiratory JJ cord-268388-kkhuzf3p 100 4 syndrome syndrome NN cord-268388-kkhuzf3p 100 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 100 6 : : : cord-268388-kkhuzf3p 101 1 Epidemic epidemic NN cord-268388-kkhuzf3p 101 2 potential potential NN cord-268388-kkhuzf3p 101 3 or or CC cord-268388-kkhuzf3p 101 4 a a DT cord-268388-kkhuzf3p 101 5 storm storm NN cord-268388-kkhuzf3p 101 6 in in IN cord-268388-kkhuzf3p 101 7 a a DT cord-268388-kkhuzf3p 101 8 teacup teacup NN cord-268388-kkhuzf3p 101 9 ? ? . cord-268388-kkhuzf3p 102 1 Global Global NNP cord-268388-kkhuzf3p 102 2 Alert Alert NNP cord-268388-kkhuzf3p 102 3 and and CC cord-268388-kkhuzf3p 102 4 Response response NN cord-268388-kkhuzf3p 102 5 : : : cord-268388-kkhuzf3p 102 6 Middle Middle NNP cord-268388-kkhuzf3p 102 7 East East NNP cord-268388-kkhuzf3p 102 8 respiratory respiratory JJ cord-268388-kkhuzf3p 102 9 syndrome syndrome NN cord-268388-kkhuzf3p 102 10 coronavirus coronavirus NN cord-268388-kkhuzf3p 102 11 ( ( -LRB- cord-268388-kkhuzf3p 102 12 MERS MERS NNP cord-268388-kkhuzf3p 102 13 - - HYPH cord-268388-kkhuzf3p 102 14 CoV CoV NNP cord-268388-kkhuzf3p 102 15 ) ) -RRB- cord-268388-kkhuzf3p 103 1 -update -update . cord-268388-kkhuzf3p 104 1 Middle Middle NNP cord-268388-kkhuzf3p 104 2 east east NNP cord-268388-kkhuzf3p 104 3 respiratory respiratory JJ cord-268388-kkhuzf3p 104 4 syndrome syndrome NN cord-268388-kkhuzf3p 104 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 104 6 ( ( -LRB- cord-268388-kkhuzf3p 104 7 MERS MERS NNP cord-268388-kkhuzf3p 104 8 - - HYPH cord-268388-kkhuzf3p 104 9 CoV CoV NNP cord-268388-kkhuzf3p 104 10 ) ) -RRB- cord-268388-kkhuzf3p 104 11 RNA RNA NNP cord-268388-kkhuzf3p 104 12 and and CC cord-268388-kkhuzf3p 104 13 neutralising neutralise VBG cord-268388-kkhuzf3p 104 14 antibodies antibody NNS cord-268388-kkhuzf3p 104 15 in in IN cord-268388-kkhuzf3p 104 16 milk milk NN cord-268388-kkhuzf3p 104 17 collected collect VBN cord-268388-kkhuzf3p 104 18 according accord VBG cord-268388-kkhuzf3p 104 19 to to IN cord-268388-kkhuzf3p 104 20 local local JJ cord-268388-kkhuzf3p 104 21 customs custom NNS cord-268388-kkhuzf3p 104 22 from from IN cord-268388-kkhuzf3p 104 23 dromedary dromedary NN cord-268388-kkhuzf3p 104 24 camels camel NNS cord-268388-kkhuzf3p 104 25 , , , cord-268388-kkhuzf3p 104 26 qatar qatar NNP cord-268388-kkhuzf3p 104 27 Middle Middle NNP cord-268388-kkhuzf3p 104 28 east east NNP cord-268388-kkhuzf3p 104 29 respiratory respiratory JJ cord-268388-kkhuzf3p 104 30 syndrome syndrome NN cord-268388-kkhuzf3p 104 31 coronavirus coronavirus NN cord-268388-kkhuzf3p 104 32 ( ( -LRB- cord-268388-kkhuzf3p 104 33 MERS MERS NNP cord-268388-kkhuzf3p 104 34 - - HYPH cord-268388-kkhuzf3p 104 35 CoV CoV NNP cord-268388-kkhuzf3p 104 36 ) ) -RRB- cord-268388-kkhuzf3p 104 37 in in IN cord-268388-kkhuzf3p 104 38 dromedary dromedary NN cord-268388-kkhuzf3p 104 39 camels camel NNS cord-268388-kkhuzf3p 105 1 Middle Middle NNP cord-268388-kkhuzf3p 105 2 east east NNP cord-268388-kkhuzf3p 105 3 respiratory respiratory JJ cord-268388-kkhuzf3p 105 4 syndrome syndrome NN cord-268388-kkhuzf3p 105 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 105 6 in in IN cord-268388-kkhuzf3p 105 7 dromedary dromedary NN cord-268388-kkhuzf3p 105 8 camels camel NNS cord-268388-kkhuzf3p 105 9 : : : cord-268388-kkhuzf3p 106 1 An an DT cord-268388-kkhuzf3p 106 2 outbreak outbreak NN cord-268388-kkhuzf3p 106 3 investigation investigation NN cord-268388-kkhuzf3p 106 4 Hospital Hospital NNP cord-268388-kkhuzf3p 106 5 outbreak outbreak NN cord-268388-kkhuzf3p 106 6 of of IN cord-268388-kkhuzf3p 107 1 middle middle NNP cord-268388-kkhuzf3p 107 2 east east NNP cord-268388-kkhuzf3p 107 3 respiratory respiratory JJ cord-268388-kkhuzf3p 107 4 syndrome syndrome NN cord-268388-kkhuzf3p 107 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 108 1 Interhuman interhuman JJ cord-268388-kkhuzf3p 108 2 transmissibility transmissibility NN cord-268388-kkhuzf3p 108 3 of of IN cord-268388-kkhuzf3p 108 4 middle middle NNP cord-268388-kkhuzf3p 108 5 east east NNP cord-268388-kkhuzf3p 108 6 respiratory respiratory JJ cord-268388-kkhuzf3p 108 7 syndrome syndrome NN cord-268388-kkhuzf3p 108 8 coronavirus coronavirus NN cord-268388-kkhuzf3p 108 9 : : : cord-268388-kkhuzf3p 108 10 Estimation estimation NN cord-268388-kkhuzf3p 108 11 of of IN cord-268388-kkhuzf3p 108 12 pandemic pandemic NN cord-268388-kkhuzf3p 108 13 risk risk NN cord-268388-kkhuzf3p 108 14 Middle Middle NNP cord-268388-kkhuzf3p 108 15 east east NNP cord-268388-kkhuzf3p 108 16 respiratory respiratory JJ cord-268388-kkhuzf3p 108 17 syndrome syndrome NN cord-268388-kkhuzf3p 108 18 coronavirus coronavirus NN cord-268388-kkhuzf3p 108 19 : : : cord-268388-kkhuzf3p 108 20 Quantification quantification NN cord-268388-kkhuzf3p 108 21 of of IN cord-268388-kkhuzf3p 108 22 the the DT cord-268388-kkhuzf3p 108 23 extent extent NN cord-268388-kkhuzf3p 108 24 of of IN cord-268388-kkhuzf3p 108 25 the the DT cord-268388-kkhuzf3p 108 26 epidemic epidemic NN cord-268388-kkhuzf3p 108 27 , , , cord-268388-kkhuzf3p 108 28 surveillance surveillance NN cord-268388-kkhuzf3p 108 29 biases bias NNS cord-268388-kkhuzf3p 108 30 , , , cord-268388-kkhuzf3p 108 31 and and CC cord-268388-kkhuzf3p 108 32 transmissibility transmissibility NN cord-268388-kkhuzf3p 108 33 Middle Middle NNP cord-268388-kkhuzf3p 108 34 east east NNP cord-268388-kkhuzf3p 108 35 respiratory respiratory JJ cord-268388-kkhuzf3p 108 36 syndrome syndrome NN cord-268388-kkhuzf3p 108 37 coronavirus coronavirus NN cord-268388-kkhuzf3p 108 38 ( ( -LRB- cord-268388-kkhuzf3p 108 39 MERS MERS NNP cord-268388-kkhuzf3p 108 40 - - HYPH cord-268388-kkhuzf3p 108 41 CoV CoV NNP cord-268388-kkhuzf3p 108 42 ) ) -RRB- cord-268388-kkhuzf3p 108 43 causes cause VBZ cord-268388-kkhuzf3p 108 44 transient transient JJ cord-268388-kkhuzf3p 108 45 lower low JJR cord-268388-kkhuzf3p 108 46 respiratory respiratory JJ cord-268388-kkhuzf3p 108 47 tract tract NN cord-268388-kkhuzf3p 108 48 infection infection NN cord-268388-kkhuzf3p 108 49 in in IN cord-268388-kkhuzf3p 108 50 rhesus rhesu NNS cord-268388-kkhuzf3p 108 51 macaques macaque NNS cord-268388-kkhuzf3p 109 1 Interim interim JJ cord-268388-kkhuzf3p 109 2 infection infection NN cord-268388-kkhuzf3p 109 3 control control NN cord-268388-kkhuzf3p 109 4 and and CC cord-268388-kkhuzf3p 109 5 prevention prevention NN cord-268388-kkhuzf3p 109 6 recommendations recommendation NNS cord-268388-kkhuzf3p 109 7 for for IN cord-268388-kkhuzf3p 109 8 hospitalized hospitalize VBN cord-268388-kkhuzf3p 109 9 patients patient NNS cord-268388-kkhuzf3p 109 10 with with IN cord-268388-kkhuzf3p 109 11 MERS MERS NNP cord-268388-kkhuzf3p 109 12 - - HYPH cord-268388-kkhuzf3p 109 13 CoV CoV NNP cord-268388-kkhuzf3p 109 14 MERS MERS NNP cord-268388-kkhuzf3p 109 15 Case Case NNP cord-268388-kkhuzf3p 109 16 Definition Definition NNP cord-268388-kkhuzf3p 109 17 MERS MERS NNP cord-268388-kkhuzf3p 109 18 clinical clinical JJ cord-268388-kkhuzf3p 109 19 update update NN cord-268388-kkhuzf3p 109 20 from from IN cord-268388-kkhuzf3p 109 21 the the DT cord-268388-kkhuzf3p 109 22 IDSA IDSA NNP cord-268388-kkhuzf3p 109 23 Center Center NNP cord-268388-kkhuzf3p 109 24 for for IN cord-268388-kkhuzf3p 109 25 Disease Disease NNP cord-268388-kkhuzf3p 109 26 Control Control NNP cord-268388-kkhuzf3p 109 27 and and CC cord-268388-kkhuzf3p 109 28 Prevention Prevention NNP cord-268388-kkhuzf3p 109 29 CDC CDC NNP cord-268388-kkhuzf3p 109 30 Epidemiological Epidemiological NNP cord-268388-kkhuzf3p 109 31 , , , cord-268388-kkhuzf3p 109 32 demographic demographic JJ cord-268388-kkhuzf3p 109 33 , , , cord-268388-kkhuzf3p 109 34 and and CC cord-268388-kkhuzf3p 109 35 clinical clinical JJ cord-268388-kkhuzf3p 109 36 characteristics characteristic NNS cord-268388-kkhuzf3p 109 37 of of IN cord-268388-kkhuzf3p 109 38 47 47 CD cord-268388-kkhuzf3p 109 39 cases case NNS cord-268388-kkhuzf3p 109 40 of of IN cord-268388-kkhuzf3p 109 41 middle middle JJ cord-268388-kkhuzf3p 109 42 east east NNP cord-268388-kkhuzf3p 109 43 respiratory respiratory JJ cord-268388-kkhuzf3p 109 44 syndrome syndrome NN cord-268388-kkhuzf3p 109 45 coronavirus coronavirus NN cord-268388-kkhuzf3p 109 46 disease disease NN cord-268388-kkhuzf3p 109 47 from from IN cord-268388-kkhuzf3p 109 48 saudi saudi NNP cord-268388-kkhuzf3p 109 49 arabia arabia NNP cord-268388-kkhuzf3p 109 50 : : : cord-268388-kkhuzf3p 110 1 A a DT cord-268388-kkhuzf3p 110 2 descriptive descriptive JJ cord-268388-kkhuzf3p 110 3 study study NN cord-268388-kkhuzf3p 110 4 Clinical clinical JJ cord-268388-kkhuzf3p 110 5 features feature NNS cord-268388-kkhuzf3p 110 6 and and CC cord-268388-kkhuzf3p 110 7 viral viral JJ cord-268388-kkhuzf3p 110 8 diagnosis diagnosis NN cord-268388-kkhuzf3p 110 9 of of IN cord-268388-kkhuzf3p 110 10 two two CD cord-268388-kkhuzf3p 110 11 cases case NNS cord-268388-kkhuzf3p 110 12 of of IN cord-268388-kkhuzf3p 110 13 infection infection NN cord-268388-kkhuzf3p 110 14 with with IN cord-268388-kkhuzf3p 110 15 middle middle JJ cord-268388-kkhuzf3p 110 16 east east NNP cord-268388-kkhuzf3p 110 17 respiratory respiratory JJ cord-268388-kkhuzf3p 110 18 syndrome syndrome NN cord-268388-kkhuzf3p 110 19 coronavirus coronavirus NN cord-268388-kkhuzf3p 110 20 : : : cord-268388-kkhuzf3p 111 1 A a DT cord-268388-kkhuzf3p 111 2 report report NN cord-268388-kkhuzf3p 111 3 of of IN cord-268388-kkhuzf3p 111 4 nosocomial nosocomial JJ cord-268388-kkhuzf3p 111 5 transmission transmission NNP cord-268388-kkhuzf3p 111 6 Family Family NNP cord-268388-kkhuzf3p 111 7 cluster cluster NN cord-268388-kkhuzf3p 111 8 of of IN cord-268388-kkhuzf3p 111 9 middle middle NNP cord-268388-kkhuzf3p 111 10 east east NNP cord-268388-kkhuzf3p 111 11 respiratory respiratory JJ cord-268388-kkhuzf3p 111 12 syndrome syndrome NN cord-268388-kkhuzf3p 111 13 coronavirus coronavirus NN cord-268388-kkhuzf3p 111 14 infections infection NNS cord-268388-kkhuzf3p 112 1 A a DT cord-268388-kkhuzf3p 112 2 patient patient NN cord-268388-kkhuzf3p 112 3 with with IN cord-268388-kkhuzf3p 112 4 severe severe JJ cord-268388-kkhuzf3p 112 5 respiratory respiratory JJ cord-268388-kkhuzf3p 112 6 failure failure NN cord-268388-kkhuzf3p 112 7 caused cause VBN cord-268388-kkhuzf3p 112 8 by by IN cord-268388-kkhuzf3p 112 9 novel novel JJ cord-268388-kkhuzf3p 112 10 human human JJ cord-268388-kkhuzf3p 112 11 coronavirus coronavirus NN cord-268388-kkhuzf3p 113 1 A a DT cord-268388-kkhuzf3p 113 2 family family NN cord-268388-kkhuzf3p 113 3 cluster cluster NN cord-268388-kkhuzf3p 113 4 of of IN cord-268388-kkhuzf3p 113 5 middle middle NNP cord-268388-kkhuzf3p 113 6 east east NNP cord-268388-kkhuzf3p 113 7 respiratory respiratory JJ cord-268388-kkhuzf3p 113 8 syndrome syndrome NN cord-268388-kkhuzf3p 113 9 coronavirus coronavirus NN cord-268388-kkhuzf3p 113 10 infections infection NNS cord-268388-kkhuzf3p 113 11 related relate VBN cord-268388-kkhuzf3p 113 12 to to IN cord-268388-kkhuzf3p 113 13 a a DT cord-268388-kkhuzf3p 113 14 likely likely RB cord-268388-kkhuzf3p 113 15 unrecognized unrecognized JJ cord-268388-kkhuzf3p 113 16 asymptomatic asymptomatic JJ cord-268388-kkhuzf3p 113 17 or or CC cord-268388-kkhuzf3p 113 18 mild mild JJ cord-268388-kkhuzf3p 113 19 case case NN cord-268388-kkhuzf3p 113 20 Clinical clinical JJ cord-268388-kkhuzf3p 113 21 features feature NNS cord-268388-kkhuzf3p 113 22 and and CC cord-268388-kkhuzf3p 113 23 virological virological JJ cord-268388-kkhuzf3p 113 24 analysis analysis NN cord-268388-kkhuzf3p 113 25 of of IN cord-268388-kkhuzf3p 113 26 a a DT cord-268388-kkhuzf3p 113 27 case case NN cord-268388-kkhuzf3p 113 28 of of IN cord-268388-kkhuzf3p 113 29 middle middle NNP cord-268388-kkhuzf3p 113 30 east east NNP cord-268388-kkhuzf3p 113 31 respiratory respiratory JJ cord-268388-kkhuzf3p 113 32 syndrome syndrome NN cord-268388-kkhuzf3p 113 33 coronavirus coronavirus NN cord-268388-kkhuzf3p 113 34 infection infection NN cord-268388-kkhuzf3p 113 35 Epidemiological epidemiological JJ cord-268388-kkhuzf3p 113 36 findings finding NNS cord-268388-kkhuzf3p 113 37 from from IN cord-268388-kkhuzf3p 113 38 a a DT cord-268388-kkhuzf3p 113 39 retrospective retrospective JJ cord-268388-kkhuzf3p 113 40 investigation investigation NN cord-268388-kkhuzf3p 113 41 WHO who WP cord-268388-kkhuzf3p 113 42 concludes conclude VBZ cord-268388-kkhuzf3p 113 43 MERS MERS NNP cord-268388-kkhuzf3p 113 44 - - HYPH cord-268388-kkhuzf3p 113 45 CoV CoV NNP cord-268388-kkhuzf3p 113 46 mission mission NN cord-268388-kkhuzf3p 113 47 in in IN cord-268388-kkhuzf3p 113 48 Saudi Saudi NNP cord-268388-kkhuzf3p 113 49 Arabia Arabia NNP cord-268388-kkhuzf3p 113 50 MERS MERS NNP cord-268388-kkhuzf3p 113 51 - - HYPH cord-268388-kkhuzf3p 113 52 CoV cov NN cord-268388-kkhuzf3p 113 53 enigma enigma NN cord-268388-kkhuzf3p 113 54 deepens deepen VBZ cord-268388-kkhuzf3p 113 55 as as IN cord-268388-kkhuzf3p 113 56 reported report VBN cord-268388-kkhuzf3p 113 57 cases case NNS cord-268388-kkhuzf3p 113 58 surge surge VBP cord-268388-kkhuzf3p 113 59 Geographic geographic JJ cord-268388-kkhuzf3p 113 60 distribution distribution NN cord-268388-kkhuzf3p 113 61 of of IN cord-268388-kkhuzf3p 113 62 MERS MERS NNP cord-268388-kkhuzf3p 113 63 coronavirus coronavirus NN cord-268388-kkhuzf3p 113 64 among among IN cord-268388-kkhuzf3p 113 65 dromedary dromedary NN cord-268388-kkhuzf3p 113 66 camels camel NNS cord-268388-kkhuzf3p 113 67 MERS MERS NNP cord-268388-kkhuzf3p 113 68 coronaviruses coronaviruse NNS cord-268388-kkhuzf3p 113 69 in in IN cord-268388-kkhuzf3p 113 70 dromedary dromedary NN cord-268388-kkhuzf3p 113 71 camels camel NNS cord-268388-kkhuzf3p 114 1 Middle Middle NNP cord-268388-kkhuzf3p 114 2 East East NNP cord-268388-kkhuzf3p 114 3 respiratory respiratory JJ cord-268388-kkhuzf3p 114 4 syndrome syndrome NN cord-268388-kkhuzf3p 114 5 coronavirus coronavirus NN cord-268388-kkhuzf3p 114 6 ( ( -LRB- cord-268388-kkhuzf3p 114 7 MERS MERS NNP cord-268388-kkhuzf3p 114 8 - - HYPH cord-268388-kkhuzf3p 114 9 CoV CoV NNP cord-268388-kkhuzf3p 114 10 ) ) -RRB- cord-268388-kkhuzf3p 114 11 summary summary NN cord-268388-kkhuzf3p 114 12 and and CC cord-268388-kkhuzf3p 114 13 literature literature NN cord-268388-kkhuzf3p 114 14 update update NN cord-268388-kkhuzf3p 114 15 as as IN cord-268388-kkhuzf3p 114 16 of of IN cord-268388-kkhuzf3p 114 17 20 20 CD cord-268388-kkhuzf3p 114 18 Prevalence prevalence NN cord-268388-kkhuzf3p 114 19 of of IN cord-268388-kkhuzf3p 114 20 MERS MERS NNP cord-268388-kkhuzf3p 114 21 - - HYPH cord-268388-kkhuzf3p 114 22 CoV CoV NNP cord-268388-kkhuzf3p 114 23 nasal nasal NN cord-268388-kkhuzf3p 114 24 carriage carriage NN cord-268388-kkhuzf3p 114 25 and and CC cord-268388-kkhuzf3p 114 26 compliance compliance NN cord-268388-kkhuzf3p 114 27 with with IN cord-268388-kkhuzf3p 114 28 the the DT cord-268388-kkhuzf3p 114 29 saudi saudi JJ cord-268388-kkhuzf3p 114 30 health health NN cord-268388-kkhuzf3p 114 31 recommendations recommendation NNS cord-268388-kkhuzf3p 114 32 among among IN cord-268388-kkhuzf3p 114 33 pilgrims pilgrim NNS cord-268388-kkhuzf3p 114 34 attending attend VBG cord-268388-kkhuzf3p 114 35 the the DT cord-268388-kkhuzf3p 114 36 2013 2013 CD cord-268388-kkhuzf3p 114 37 hajj hajj NN cord-268388-kkhuzf3p 114 38 Lack lack NN cord-268388-kkhuzf3p 114 39 of of IN cord-268388-kkhuzf3p 114 40 MERS MERS NNP cord-268388-kkhuzf3p 114 41 coronavirus coronavirus NN cord-268388-kkhuzf3p 114 42 but but CC cord-268388-kkhuzf3p 114 43 prevalence prevalence NN cord-268388-kkhuzf3p 114 44 of of IN cord-268388-kkhuzf3p 114 45 influenza influenza NN cord-268388-kkhuzf3p 114 46 virus virus NN cord-268388-kkhuzf3p 114 47 in in IN cord-268388-kkhuzf3p 114 48 french french JJ cord-268388-kkhuzf3p 114 49 pilgrims pilgrim NNS cord-268388-kkhuzf3p 114 50 after after IN cord-268388-kkhuzf3p 114 51 2013 2013 CD cord-268388-kkhuzf3p 114 52 hajj hajj NN cord-268388-kkhuzf3p 115 1 The the DT cord-268388-kkhuzf3p 115 2 receptor receptor NN cord-268388-kkhuzf3p 115 3 binding bind VBG cord-268388-kkhuzf3p 115 4 domain domain NN cord-268388-kkhuzf3p 115 5 of of IN cord-268388-kkhuzf3p 115 6 MERS MERS NNP cord-268388-kkhuzf3p 115 7 - - HYPH cord-268388-kkhuzf3p 115 8 CoV CoV NNP cord-268388-kkhuzf3p 115 9 : : : cord-268388-kkhuzf3p 115 10 The the DT cord-268388-kkhuzf3p 115 11 dawn dawn NN cord-268388-kkhuzf3p 115 12 of of IN cord-268388-kkhuzf3p 115 13 vaccine vaccine NN cord-268388-kkhuzf3p 115 14 and and CC cord-268388-kkhuzf3p 115 15 treatment treatment NN cord-268388-kkhuzf3p 115 16 development development NN cord-268388-kkhuzf3p 115 17 Proteolytic Proteolytic NNP cord-268388-kkhuzf3p 115 18 processing processing NN cord-268388-kkhuzf3p 115 19 , , , cord-268388-kkhuzf3p 115 20 deubiquitinase deubiquitinase NN cord-268388-kkhuzf3p 115 21 and and CC cord-268388-kkhuzf3p 115 22 interferon interferon NN cord-268388-kkhuzf3p 115 23 antagonist antagonist NN cord-268388-kkhuzf3p 115 24 activities activity NNS cord-268388-kkhuzf3p 115 25 of of IN cord-268388-kkhuzf3p 115 26 middle middle NNP cord-268388-kkhuzf3p 115 27 east east NNP cord-268388-kkhuzf3p 115 28 respiratory respiratory JJ cord-268388-kkhuzf3p 115 29 syndrome syndrome NN cord-268388-kkhuzf3p 115 30 coronavirus coronavirus NN cord-268388-kkhuzf3p 115 31 papain papain NN cord-268388-kkhuzf3p 115 32 - - HYPH cord-268388-kkhuzf3p 115 33 like like JJ cord-268388-kkhuzf3p 115 34 protease protease NN cord-268388-kkhuzf3p 116 1 What what WP cord-268388-kkhuzf3p 116 2 are be VBP cord-268388-kkhuzf3p 116 3 our -PRON- PRP$ cord-268388-kkhuzf3p 116 4 pharmacotherapeutic pharmacotherapeutic JJ cord-268388-kkhuzf3p 116 5 options option NNS cord-268388-kkhuzf3p 116 6 for for IN cord-268388-kkhuzf3p 116 7 MERS MERS NNP cord-268388-kkhuzf3p 116 8 - - HYPH cord-268388-kkhuzf3p 116 9 CoV CoV NNP cord-268388-kkhuzf3p 116 10 ? ? . cord-268388-kkhuzf3p 117 1 International International NNP cord-268388-kkhuzf3p 117 2 Severe Severe NNP cord-268388-kkhuzf3p 117 3 Acute Acute NNP cord-268388-kkhuzf3p 117 4 Respiratory Respiratory NNP cord-268388-kkhuzf3p 117 5 & & CC cord-268388-kkhuzf3p 117 6 Emerging Emerging NNP cord-268388-kkhuzf3p 117 7 Infection Infection NNP cord-268388-kkhuzf3p 117 8 Consortium Consortium NNP cord-268388-kkhuzf3p 117 9 ( ( -LRB- cord-268388-kkhuzf3p 117 10 ISARIC)-Clinical ISARIC)-Clinical NNP cord-268388-kkhuzf3p 117 11 Decision Decision NNP cord-268388-kkhuzf3p 117 12 Making Making NNP cord-268388-kkhuzf3p 117 13 Tool tool NN cord-268388-kkhuzf3p 117 14 for for IN cord-268388-kkhuzf3p 117 15 Treatment treatment NN cord-268388-kkhuzf3p 117 16 of of IN cord-268388-kkhuzf3p 117 17 MERS MERS NNP cord-268388-kkhuzf3p 117 18 - - HYPH cord-268388-kkhuzf3p 117 19 CoV CoV NNP cord-268388-kkhuzf3p 117 20 v.1.1 v.1.1 ADD cord-268388-kkhuzf3p 118 1 An an DT cord-268388-kkhuzf3p 118 2 animal animal NN cord-268388-kkhuzf3p 118 3 model model NN cord-268388-kkhuzf3p 118 4 of of IN cord-268388-kkhuzf3p 118 5 MERS MERS NNP cord-268388-kkhuzf3p 118 6 produced produce VBN cord-268388-kkhuzf3p 118 7 by by IN cord-268388-kkhuzf3p 118 8 infection infection NN cord-268388-kkhuzf3p 118 9 of of IN cord-268388-kkhuzf3p 118 10 rhesus rhesu NNS cord-268388-kkhuzf3p 118 11 macaques macaque NNS cord-268388-kkhuzf3p 118 12 with with IN cord-268388-kkhuzf3p 118 13 MERS MERS NNP cord-268388-kkhuzf3p 118 14 coronavirus coronavirus NNP cord-268388-kkhuzf3p 119 1 Ribavirin ribavirin NN cord-268388-kkhuzf3p 119 2 and and CC cord-268388-kkhuzf3p 119 3 interferon interferon NN cord-268388-kkhuzf3p 119 4 therapy therapy NN cord-268388-kkhuzf3p 119 5 in in IN cord-268388-kkhuzf3p 119 6 patients patient NNS cord-268388-kkhuzf3p 119 7 infected infect VBN cord-268388-kkhuzf3p 119 8 with with IN cord-268388-kkhuzf3p 119 9 the the DT cord-268388-kkhuzf3p 119 10 middle middle NNP cord-268388-kkhuzf3p 119 11 east east NNP cord-268388-kkhuzf3p 119 12 respiratory respiratory JJ cord-268388-kkhuzf3p 119 13 syndrome syndrome NN cord-268388-kkhuzf3p 119 14 coronavirus coronavirus NN cord-268388-kkhuzf3p 119 15 : : : cord-268388-kkhuzf3p 120 1 An an DT cord-268388-kkhuzf3p 120 2 observational observational JJ cord-268388-kkhuzf3p 120 3 study study NN cord-268388-kkhuzf3p 120 4 Repurposing repurposing NN cord-268388-kkhuzf3p 120 5 of of IN cord-268388-kkhuzf3p 120 6 clinically clinically RB cord-268388-kkhuzf3p 120 7 developed develop VBN cord-268388-kkhuzf3p 120 8 drugs drug NNS cord-268388-kkhuzf3p 120 9 for for IN cord-268388-kkhuzf3p 120 10 treatment treatment NN cord-268388-kkhuzf3p 120 11 of of IN cord-268388-kkhuzf3p 120 12 middle middle JJ cord-268388-kkhuzf3p 120 13 east east NNP cord-268388-kkhuzf3p 120 14 respiratory respiratory JJ cord-268388-kkhuzf3p 120 15 coronavirus coronavirus NN cord-268388-kkhuzf3p 120 16 infection infection NN cord-268388-kkhuzf3p 121 1 The the DT cord-268388-kkhuzf3p 121 2 authors author NNS cord-268388-kkhuzf3p 121 3 would would MD cord-268388-kkhuzf3p 121 4 like like VB cord-268388-kkhuzf3p 121 5 to to TO cord-268388-kkhuzf3p 121 6 acknowledge acknowledge VB cord-268388-kkhuzf3p 121 7 Sima Sima NNP cord-268388-kkhuzf3p 121 8 L. L. NNP cord-268388-kkhuzf3p 121 9 Sharara Sharara NNP cord-268388-kkhuzf3p 121 10 for for IN cord-268388-kkhuzf3p 121 11 editing edit VBG cord-268388-kkhuzf3p 121 12 the the DT cord-268388-kkhuzf3p 121 13 manuscript manuscript NN cord-268388-kkhuzf3p 121 14 . . .