id sid tid token lemma pos cord-278511-je1509ar 1 1 key key NN cord-278511-je1509ar 1 2 : : : cord-278511-je1509ar 1 3 cord-278511-je1509ar cord-278511-je1509ar CD cord-278511-je1509ar 1 4 authors author NNS cord-278511-je1509ar 1 5 : : : cord-278511-je1509ar 1 6 Wang Wang NNP cord-278511-je1509ar 1 7 , , , cord-278511-je1509ar 1 8 David David NNP cord-278511-je1509ar 1 9 title title NN cord-278511-je1509ar 1 10 : : : cord-278511-je1509ar 1 11 5 5 CD cord-278511-je1509ar 1 12 challenges challenge NNS cord-278511-je1509ar 1 13 in in IN cord-278511-je1509ar 1 14 understanding understand VBG cord-278511-je1509ar 1 15 the the DT cord-278511-je1509ar 1 16 role role NN cord-278511-je1509ar 1 17 of of IN cord-278511-je1509ar 1 18 the the DT cord-278511-je1509ar 1 19 virome virome NNP cord-278511-je1509ar 1 20 in in IN cord-278511-je1509ar 1 21 health health NN cord-278511-je1509ar 1 22 and and CC cord-278511-je1509ar 1 23 disease disease NN cord-278511-je1509ar 1 24 date date NN cord-278511-je1509ar 1 25 : : : cord-278511-je1509ar 1 26 2020 2020 CD cord-278511-je1509ar 1 27 - - HYPH cord-278511-je1509ar 1 28 03 03 CD cord-278511-je1509ar 1 29 - - SYM cord-278511-je1509ar 1 30 26 26 CD cord-278511-je1509ar 1 31 journal journal NN cord-278511-je1509ar 1 32 : : : cord-278511-je1509ar 2 1 PLoS PLoS NNP cord-278511-je1509ar 2 2 Pathog Pathog NNP cord-278511-je1509ar 2 3 DOI DOI NNP cord-278511-je1509ar 2 4 : : : cord-278511-je1509ar 3 1 10.1371 10.1371 CD cord-278511-je1509ar 3 2 / / SYM cord-278511-je1509ar 3 3 journal.ppat.1008318 journal.ppat.1008318 NNP cord-278511-je1509ar 3 4 sha sha NNP cord-278511-je1509ar 3 5 : : : cord-278511-je1509ar 3 6 99164916540f413d1cdc1576c42d99bccea1204b 99164916540f413d1cdc1576c42d99bccea1204b NNP cord-278511-je1509ar 3 7 doc_id doc_id CD cord-278511-je1509ar 3 8 : : : cord-278511-je1509ar 3 9 278511 278511 CD cord-278511-je1509ar 4 1 cord_uid cord_uid NN cord-278511-je1509ar 4 2 : : : cord-278511-je1509ar 5 1 je1509ar je1509ar NNP cord-278511-je1509ar 5 2 nan nan NNP cord-278511-je1509ar 5 3 Comprehensive Comprehensive NNP cord-278511-je1509ar 5 4 census census NN cord-278511-je1509ar 5 5 of of IN cord-278511-je1509ar 5 6 the the DT cord-278511-je1509ar 5 7 bacterial bacterial JJ cord-278511-je1509ar 5 8 and and CC cord-278511-je1509ar 5 9 fungal fungal JJ cord-278511-je1509ar 5 10 microbiome microbiome NN cord-278511-je1509ar 5 11 can can MD cord-278511-je1509ar 5 12 be be VB cord-278511-je1509ar 5 13 achieved achieve VBN cord-278511-je1509ar 5 14 through through IN cord-278511-je1509ar 5 15 consensus consensus NN cord-278511-je1509ar 5 16 PCR PCR NNP cord-278511-je1509ar 5 17 approaches approach VBZ cord-278511-je1509ar 5 18 that that WDT cord-278511-je1509ar 5 19 target target VBP cord-278511-je1509ar 5 20 the the DT cord-278511-je1509ar 5 21 16S 16S NNPS cord-278511-je1509ar 5 22 rRNA rrna NN cord-278511-je1509ar 5 23 and and CC cord-278511-je1509ar 5 24 internal internal JJ cord-278511-je1509ar 5 25 transcribed transcribe VBN cord-278511-je1509ar 5 26 spacer spacer NN cord-278511-je1509ar 5 27 ( ( -LRB- cord-278511-je1509ar 5 28 ITS its PRP$ cord-278511-je1509ar 5 29 ) ) -RRB- cord-278511-je1509ar 5 30 loci locus NNS cord-278511-je1509ar 5 31 , , , cord-278511-je1509ar 5 32 respectively respectively RB cord-278511-je1509ar 5 33 . . . cord-278511-je1509ar 6 1 By by IN cord-278511-je1509ar 6 2 contrast contrast NN cord-278511-je1509ar 6 3 , , , cord-278511-je1509ar 6 4 there there EX cord-278511-je1509ar 6 5 is be VBZ cord-278511-je1509ar 6 6 no no DT cord-278511-je1509ar 6 7 such such JJ cord-278511-je1509ar 6 8 analogous analogous JJ cord-278511-je1509ar 6 9 conserved conserve VBN cord-278511-je1509ar 6 10 sequence sequence NN cord-278511-je1509ar 6 11 present present JJ cord-278511-je1509ar 6 12 in in IN cord-278511-je1509ar 6 13 all all DT cord-278511-je1509ar 6 14 viruses virus NNS cord-278511-je1509ar 6 15 . . . cord-278511-je1509ar 7 1 The the DT cord-278511-je1509ar 7 2 lack lack NN cord-278511-je1509ar 7 3 of of IN cord-278511-je1509ar 7 4 a a DT cord-278511-je1509ar 7 5 consensus consensus NN cord-278511-je1509ar 7 6 sequence sequence NN cord-278511-je1509ar 7 7 poses pose VBZ cord-278511-je1509ar 7 8 a a DT cord-278511-je1509ar 7 9 significant significant JJ cord-278511-je1509ar 7 10 challenge challenge NN cord-278511-je1509ar 7 11 for for IN cord-278511-je1509ar 7 12 efforts effort NNS cord-278511-je1509ar 7 13 to to TO cord-278511-je1509ar 7 14 systematically systematically RB cord-278511-je1509ar 7 15 define define VB cord-278511-je1509ar 7 16 the the DT cord-278511-je1509ar 7 17 set set NN cord-278511-je1509ar 7 18 of of IN cord-278511-je1509ar 7 19 viruses virus NNS cord-278511-je1509ar 7 20 present present JJ cord-278511-je1509ar 7 21 in in IN cord-278511-je1509ar 7 22 a a DT cord-278511-je1509ar 7 23 given give VBN cord-278511-je1509ar 7 24 specimen specimen NN cord-278511-je1509ar 7 25 . . . cord-278511-je1509ar 8 1 Rather rather RB cord-278511-je1509ar 8 2 than than IN cord-278511-je1509ar 8 3 simply simply RB cord-278511-je1509ar 8 4 amplifying amplify VBG cord-278511-je1509ar 8 5 and and CC cord-278511-je1509ar 8 6 sequencing sequence VBG cord-278511-je1509ar 8 7 a a DT cord-278511-je1509ar 8 8 signature signature NN cord-278511-je1509ar 8 9 target target NN cord-278511-je1509ar 8 10 locus locus NN cord-278511-je1509ar 8 11 , , , cord-278511-je1509ar 8 12 metagenomic metagenomic NN cord-278511-je1509ar 8 13 sequencing sequencing NN cord-278511-je1509ar 8 14 of of IN cord-278511-je1509ar 8 15 nucleic nucleic JJ cord-278511-je1509ar 8 16 acid acid NN cord-278511-je1509ar 8 17 in in IN cord-278511-je1509ar 8 18 a a DT cord-278511-je1509ar 8 19 sample sample NN cord-278511-je1509ar 8 20 is be VBZ cord-278511-je1509ar 8 21 required require VBN cord-278511-je1509ar 8 22 for for IN cord-278511-je1509ar 8 23 virus virus NN cord-278511-je1509ar 8 24 sequences sequence NNS cord-278511-je1509ar 8 25 to to TO cord-278511-je1509ar 8 26 be be VB cord-278511-je1509ar 8 27 represented represent VBN cord-278511-je1509ar 8 28 in in IN cord-278511-je1509ar 8 29 a a DT cord-278511-je1509ar 8 30 sequencing sequencing NN cord-278511-je1509ar 8 31 library library NN cord-278511-je1509ar 8 32 . . . cord-278511-je1509ar 9 1 The the DT cord-278511-je1509ar 9 2 increased increase VBN cord-278511-je1509ar 9 3 sequencing sequencing NN cord-278511-je1509ar 9 4 depth depth NN cord-278511-je1509ar 9 5 necessary necessary JJ cord-278511-je1509ar 9 6 dramatically dramatically RB cord-278511-je1509ar 9 7 increases increase VBZ cord-278511-je1509ar 9 8 the the DT cord-278511-je1509ar 9 9 cost cost NN cord-278511-je1509ar 9 10 compared compare VBN cord-278511-je1509ar 9 11 to to IN cord-278511-je1509ar 9 12 16S 16S NNP cord-278511-je1509ar 9 13 or or CC cord-278511-je1509ar 9 14 ITS its PRP$ cord-278511-je1509ar 9 15 sequencing sequencing NN cord-278511-je1509ar 9 16 . . . cord-278511-je1509ar 10 1 Moreover moreover RB cord-278511-je1509ar 10 2 , , , cord-278511-je1509ar 10 3 the the DT cord-278511-je1509ar 10 4 relative relative JJ cord-278511-je1509ar 10 5 abundance abundance NN cord-278511-je1509ar 10 6 of of IN cord-278511-je1509ar 10 7 viral viral JJ cord-278511-je1509ar 10 8 to to IN cord-278511-je1509ar 10 9 nonviral nonviral JJ cord-278511-je1509ar 10 10 nucleic nucleic JJ cord-278511-je1509ar 10 11 acids acid NNS cord-278511-je1509ar 10 12 is be VBZ cord-278511-je1509ar 10 13 an an DT cord-278511-je1509ar 10 14 important important JJ cord-278511-je1509ar 10 15 parameter parameter NN cord-278511-je1509ar 10 16 that that WDT cord-278511-je1509ar 10 17 drives drive VBZ cord-278511-je1509ar 10 18 sensitivity sensitivity NN cord-278511-je1509ar 10 19 . . . cord-278511-je1509ar 11 1 To to TO cord-278511-je1509ar 11 2 mitigate mitigate VB cord-278511-je1509ar 11 3 this this DT cord-278511-je1509ar 11 4 problem problem NN cord-278511-je1509ar 11 5 , , , cord-278511-je1509ar 11 6 physical physical JJ cord-278511-je1509ar 11 7 enrichment enrichment NN cord-278511-je1509ar 11 8 for for IN cord-278511-je1509ar 11 9 viral viral JJ cord-278511-je1509ar 11 10 particles particle NNS cord-278511-je1509ar 11 11 by by IN cord-278511-je1509ar 11 12 filtration filtration NN cord-278511-je1509ar 11 13 and/or and/or CC cord-278511-je1509ar 11 14 nuclease nuclease NN cord-278511-je1509ar 11 15 treatment treatment NN cord-278511-je1509ar 11 16 is be VBZ cord-278511-je1509ar 11 17 often often RB cord-278511-je1509ar 11 18 necessary necessary JJ cord-278511-je1509ar 11 19 . . . cord-278511-je1509ar 12 1 Another another DT cord-278511-je1509ar 12 2 consequence consequence NN cord-278511-je1509ar 12 3 of of IN cord-278511-je1509ar 12 4 the the DT cord-278511-je1509ar 12 5 requirement requirement NN cord-278511-je1509ar 12 6 for for IN cord-278511-je1509ar 12 7 metagenomic metagenomic NNP cord-278511-je1509ar 12 8 sequencing sequencing NN cord-278511-je1509ar 12 9 is be VBZ cord-278511-je1509ar 12 10 that that IN cord-278511-je1509ar 12 11 the the DT cord-278511-je1509ar 12 12 subsequent subsequent JJ cord-278511-je1509ar 12 13 bioinformatic bioinformatic JJ cord-278511-je1509ar 12 14 analysis analysis NN cord-278511-je1509ar 12 15 is be VBZ cord-278511-je1509ar 12 16 also also RB cord-278511-je1509ar 12 17 much much RB cord-278511-je1509ar 12 18 more more RBR cord-278511-je1509ar 12 19 complex complex JJ cord-278511-je1509ar 12 20 ; ; : cord-278511-je1509ar 12 21 the the DT cord-278511-je1509ar 12 22 metagenomic metagenomic NNP cord-278511-je1509ar 12 23 sequences sequence NNS cord-278511-je1509ar 12 24 must must MD cord-278511-je1509ar 12 25 be be VB cord-278511-je1509ar 12 26 aligned align VBN cord-278511-je1509ar 12 27 at at IN cord-278511-je1509ar 12 28 both both DT cord-278511-je1509ar 12 29 nucleotide nucleotide JJ cord-278511-je1509ar 12 30 and and CC cord-278511-je1509ar 12 31 amino amino NN cord-278511-je1509ar 12 32 acid acid NN cord-278511-je1509ar 12 33 levels level NNS cord-278511-je1509ar 12 34 to to IN cord-278511-je1509ar 12 35 large large JJ cord-278511-je1509ar 12 36 reference reference NN cord-278511-je1509ar 12 37 databases database NNS cord-278511-je1509ar 12 38 of of IN cord-278511-je1509ar 12 39 viral viral JJ cord-278511-je1509ar 12 40 sequences sequence NNS cord-278511-je1509ar 12 41 ( ( -LRB- cord-278511-je1509ar 12 42 not not RB cord-278511-je1509ar 12 43 just just RB cord-278511-je1509ar 12 44 to to IN cord-278511-je1509ar 12 45 a a DT cord-278511-je1509ar 12 46 database database NN cord-278511-je1509ar 12 47 of of IN cord-278511-je1509ar 12 48 reference reference NN cord-278511-je1509ar 12 49 amplicon amplicon NN cord-278511-je1509ar 12 50 nucleic nucleic JJ cord-278511-je1509ar 12 51 acid acid NN cord-278511-je1509ar 12 52 sequences sequence NNS cord-278511-je1509ar 12 53 ) ) -RRB- cord-278511-je1509ar 12 54 . . . cord-278511-je1509ar 13 1 Thus thus RB cord-278511-je1509ar 13 2 , , , cord-278511-je1509ar 13 3 the the DT cord-278511-je1509ar 13 4 experimental experimental JJ cord-278511-je1509ar 13 5 sequencing sequencing NN cord-278511-je1509ar 13 6 depth depth NN cord-278511-je1509ar 13 7 , , , cord-278511-je1509ar 13 8 computational computational JJ cord-278511-je1509ar 13 9 infrastructure infrastructure NN cord-278511-je1509ar 13 10 requirements requirement NNS cord-278511-je1509ar 13 11 , , , cord-278511-je1509ar 13 12 and and CC cord-278511-je1509ar 13 13 computing computing NN cord-278511-je1509ar 13 14 costs cost NNS cord-278511-je1509ar 13 15 are be VBP cord-278511-je1509ar 13 16 significantly significantly RB cord-278511-je1509ar 13 17 higher high JJR cord-278511-je1509ar 13 18 for for IN cord-278511-je1509ar 13 19 virome virome NN cord-278511-je1509ar 13 20 analyses analysis NNS cord-278511-je1509ar 13 21 . . . cord-278511-je1509ar 14 1 The the DT cord-278511-je1509ar 14 2 precise precise JJ cord-278511-je1509ar 14 3 experimental experimental JJ cord-278511-je1509ar 14 4 and and CC cord-278511-je1509ar 14 5 bioinformatic bioinformatic JJ cord-278511-je1509ar 14 6 analysis analysis NN cord-278511-je1509ar 14 7 steps step NNS cord-278511-je1509ar 14 8 utilized utilize VBN cord-278511-je1509ar 14 9 can can MD cord-278511-je1509ar 14 10 contribute contribute VB cord-278511-je1509ar 14 11 significantly significantly RB cord-278511-je1509ar 14 12 to to IN cord-278511-je1509ar 14 13 variability variability NN cord-278511-je1509ar 14 14 and and CC cord-278511-je1509ar 14 15 , , , cord-278511-je1509ar 14 16 in in IN cord-278511-je1509ar 14 17 some some DT cord-278511-je1509ar 14 18 instances instance NNS cord-278511-je1509ar 14 19 , , , cord-278511-je1509ar 14 20 potentially potentially RB cord-278511-je1509ar 14 21 incorrect incorrect JJ cord-278511-je1509ar 14 22 conclusions conclusion NNS cord-278511-je1509ar 14 23 . . . cord-278511-je1509ar 15 1 However however RB cord-278511-je1509ar 15 2 , , , cord-278511-je1509ar 15 3 a a DT cord-278511-je1509ar 15 4 detailed detailed JJ cord-278511-je1509ar 15 5 discussion discussion NN cord-278511-je1509ar 15 6 of of IN cord-278511-je1509ar 15 7 both both DT cord-278511-je1509ar 15 8 of of IN cord-278511-je1509ar 15 9 these these DT cord-278511-je1509ar 15 10 is be VBZ cord-278511-je1509ar 15 11 beyond beyond IN cord-278511-je1509ar 15 12 the the DT cord-278511-je1509ar 15 13 scope scope NN cord-278511-je1509ar 15 14 of of IN cord-278511-je1509ar 15 15 this this DT cord-278511-je1509ar 15 16 review review NN cord-278511-je1509ar 15 17 . . . cord-278511-je1509ar 16 1 Currently currently RB cord-278511-je1509ar 16 2 , , , cord-278511-je1509ar 16 3 classification classification NN cord-278511-je1509ar 16 4 of of IN cord-278511-je1509ar 16 5 sequence sequence NN cord-278511-je1509ar 16 6 reads read VBZ cord-278511-je1509ar 16 7 as as IN cord-278511-je1509ar 16 8 being be VBG cord-278511-je1509ar 16 9 viral viral JJ cord-278511-je1509ar 16 10 in in IN cord-278511-je1509ar 16 11 origin origin NN cord-278511-je1509ar 16 12 relies rely VBZ cord-278511-je1509ar 16 13 primarily primarily RB cord-278511-je1509ar 16 14 upon upon IN cord-278511-je1509ar 16 15 detectable detectable JJ cord-278511-je1509ar 16 16 primary primary JJ cord-278511-je1509ar 16 17 sequence sequence NN cord-278511-je1509ar 16 18 alignment alignment NN cord-278511-je1509ar 16 19 to to TO cord-278511-je1509ar 16 20 reference reference NN cord-278511-je1509ar 16 21 viruses virus NNS cord-278511-je1509ar 16 22 . . . cord-278511-je1509ar 17 1 One one CD cord-278511-je1509ar 17 2 challenge challenge NN cord-278511-je1509ar 17 3 is be VBZ cord-278511-je1509ar 17 4 that that IN cord-278511-je1509ar 17 5 , , , cord-278511-je1509ar 17 6 among among IN cord-278511-je1509ar 17 7 a1111111111 a1111111111 NN cord-278511-je1509ar 18 1 a1111111111 a1111111111 NNP cord-278511-je1509ar 18 2 a1111111111 a1111111111 NNP cord-278511-je1509ar 19 1 a1111111111 a1111111111 NNP cord-278511-je1509ar 20 1 a1111111111 a1111111111 VB cord-278511-je1509ar 20 2 those those DT cord-278511-je1509ar 20 3 that that WDT cord-278511-je1509ar 20 4 are be VBP cord-278511-je1509ar 20 5 alignable alignable JJ cord-278511-je1509ar 20 6 to to TO cord-278511-je1509ar 20 7 reference reference NN cord-278511-je1509ar 20 8 viruses virus NNS cord-278511-je1509ar 20 9 , , , cord-278511-je1509ar 20 10 sequences sequence NNS cord-278511-je1509ar 20 11 can can MD cord-278511-je1509ar 20 12 be be VB cord-278511-je1509ar 20 13 misclassified misclassifie VBN cord-278511-je1509ar 20 14 due due JJ cord-278511-je1509ar 20 15 to to IN cord-278511-je1509ar 20 16 the the DT cord-278511-je1509ar 20 17 remoteness remoteness NN cord-278511-je1509ar 20 18 of of IN cord-278511-je1509ar 20 19 the the DT cord-278511-je1509ar 20 20 similarity similarity NN cord-278511-je1509ar 20 21 and/or and/or CC cord-278511-je1509ar 20 22 low low JJ cord-278511-je1509ar 20 23 stringency stringency NN cord-278511-je1509ar 20 24 . . . cord-278511-je1509ar 21 1 An an DT cord-278511-je1509ar 21 2 even even RB cord-278511-je1509ar 21 3 more more RBR cord-278511-je1509ar 21 4 significant significant JJ cord-278511-je1509ar 21 5 problem problem NN cord-278511-je1509ar 21 6 is be VBZ cord-278511-je1509ar 21 7 that that IN cord-278511-je1509ar 21 8 in in IN cord-278511-je1509ar 21 9 most most JJS cord-278511-je1509ar 21 10 virome virome JJ cord-278511-je1509ar 21 11 studies study NNS cord-278511-je1509ar 21 12 , , , cord-278511-je1509ar 21 13 more more JJR cord-278511-je1509ar 21 14 than than IN cord-278511-je1509ar 21 15 50 50 CD cord-278511-je1509ar 21 16 % % NN cord-278511-je1509ar 21 17 of of IN cord-278511-je1509ar 21 18 the the DT cord-278511-je1509ar 21 19 sequences sequence NNS cord-278511-je1509ar 21 20 in in IN cord-278511-je1509ar 21 21 virus virus NN cord-278511-je1509ar 21 22 - - HYPH cord-278511-je1509ar 21 23 enriched enrich VBN cord-278511-je1509ar 21 24 preparations preparation NNS cord-278511-je1509ar 21 25 have have VBP cord-278511-je1509ar 21 26 no no DT cord-278511-je1509ar 21 27 detectable detectable JJ cord-278511-je1509ar 21 28 sequence sequence NN cord-278511-je1509ar 21 29 similarity similarity NN cord-278511-je1509ar 21 30 to to IN cord-278511-je1509ar 21 31 any any DT cord-278511-je1509ar 21 32 known know VBN cord-278511-je1509ar 21 33 reference reference NN cord-278511-je1509ar 21 34 sequences sequence NNS cord-278511-je1509ar 21 35 ; ; : cord-278511-je1509ar 21 36 these these DT cord-278511-je1509ar 21 37 unalignable unalignable JJ cord-278511-je1509ar 21 38 sequences sequence NNS cord-278511-je1509ar 21 39 are be VBP cord-278511-je1509ar 21 40 referred refer VBN cord-278511-je1509ar 21 41 to to IN cord-278511-je1509ar 21 42 as as RB cord-278511-je1509ar 21 43 viral viral JJ cord-278511-je1509ar 21 44 " " `` cord-278511-je1509ar 21 45 dark dark JJ cord-278511-je1509ar 21 46 matter matter NN cord-278511-je1509ar 21 47 " " '' cord-278511-je1509ar 21 48 [ [ -LRB- cord-278511-je1509ar 21 49 8 8 CD cord-278511-je1509ar 21 50 ] ] -RRB- cord-278511-je1509ar 21 51 and and CC cord-278511-je1509ar 21 52 may may MD cord-278511-je1509ar 21 53 include include VB cord-278511-je1509ar 21 54 novel novel JJ cord-278511-je1509ar 21 55 , , , cord-278511-je1509ar 21 56 highly highly RB cord-278511-je1509ar 21 57 divergent divergent JJ cord-278511-je1509ar 21 58 viruses virus NNS cord-278511-je1509ar 21 59 that that WDT cord-278511-je1509ar 21 60 are be VBP cord-278511-je1509ar 21 61 unrecognizable unrecognizable JJ cord-278511-je1509ar 21 62 . . . cord-278511-je1509ar 22 1 Thus thus RB cord-278511-je1509ar 22 2 , , , cord-278511-je1509ar 22 3 most most RBS cord-278511-je1509ar 22 4 current current JJ cord-278511-je1509ar 22 5 virome virome NN cord-278511-je1509ar 22 6 studies study NNS cord-278511-je1509ar 22 7 are be VBP cord-278511-je1509ar 22 8 presenting present VBG cord-278511-je1509ar 22 9 only only RB cord-278511-je1509ar 22 10 a a DT cord-278511-je1509ar 22 11 partial partial JJ cord-278511-je1509ar 22 12 view view NN cord-278511-je1509ar 22 13 of of IN cord-278511-je1509ar 22 14 the the DT cord-278511-je1509ar 22 15 virome virome NN cord-278511-je1509ar 22 16 because because IN cord-278511-je1509ar 22 17 the the DT cord-278511-je1509ar 22 18 dark dark JJ cord-278511-je1509ar 22 19 matter matter NN cord-278511-je1509ar 22 20 sequences sequence NNS cord-278511-je1509ar 22 21 are be VBP cord-278511-je1509ar 22 22 typically typically RB cord-278511-je1509ar 22 23 ignored ignore VBN cord-278511-je1509ar 22 24 . . . cord-278511-je1509ar 23 1 The the DT cord-278511-je1509ar 23 2 dark dark JJ cord-278511-je1509ar 23 3 matter matter NN cord-278511-je1509ar 23 4 clearly clearly RB cord-278511-je1509ar 23 5 harbors harbor VBZ cord-278511-je1509ar 23 6 hidden hide VBN cord-278511-je1509ar 23 7 treasures treasure NNS cord-278511-je1509ar 23 8 because because IN cord-278511-je1509ar 23 9 mining mining NN cord-278511-je1509ar 23 10 of of IN cord-278511-je1509ar 23 11 the the DT cord-278511-je1509ar 23 12 dark dark JJ cord-278511-je1509ar 23 13 matter matter NN cord-278511-je1509ar 23 14 has have VBZ cord-278511-je1509ar 23 15 led lead VBN cord-278511-je1509ar 23 16 to to IN cord-278511-je1509ar 23 17 discoveries discovery NNS cord-278511-je1509ar 23 18 such such JJ cord-278511-je1509ar 23 19 as as IN cord-278511-je1509ar 23 20 crAssphage crAssphage NNP cord-278511-je1509ar 23 21 , , , cord-278511-je1509ar 23 22 the the DT cord-278511-je1509ar 23 23 most most RBS cord-278511-je1509ar 23 24 abundant abundant JJ cord-278511-je1509ar 23 25 bacteriophage bacteriophage NN cord-278511-je1509ar 23 26 in in IN cord-278511-je1509ar 23 27 human human JJ cord-278511-je1509ar 23 28 enteric enteric JJ cord-278511-je1509ar 23 29 viromes virome NNS cord-278511-je1509ar 23 30 [ [ -LRB- cord-278511-je1509ar 23 31 9 9 CD cord-278511-je1509ar 23 32 ] ] -RRB- cord-278511-je1509ar 23 33 . . . cord-278511-je1509ar 24 1 To to TO cord-278511-je1509ar 24 2 computationally computationally RB cord-278511-je1509ar 24 3 address address VB cord-278511-je1509ar 24 4 the the DT cord-278511-je1509ar 24 5 dark dark JJ cord-278511-je1509ar 24 6 matter matter NN cord-278511-je1509ar 24 7 , , , cord-278511-je1509ar 24 8 new new JJ cord-278511-je1509ar 24 9 and and CC cord-278511-je1509ar 24 10 improved improved JJ cord-278511-je1509ar 24 11 data datum NNS cord-278511-je1509ar 24 12 mining mining NN cord-278511-je1509ar 24 13 strategies strategy NNS cord-278511-je1509ar 24 14 are be VBP cord-278511-je1509ar 24 15 needed need VBN cord-278511-je1509ar 24 16 . . . cord-278511-je1509ar 25 1 One one CD cord-278511-je1509ar 25 2 approach approach NN cord-278511-je1509ar 25 3 is be VBZ cord-278511-je1509ar 25 4 to to TO cord-278511-je1509ar 25 5 apply apply VB cord-278511-je1509ar 25 6 methods method NNS cord-278511-je1509ar 25 7 superior superior JJ cord-278511-je1509ar 25 8 at at IN cord-278511-je1509ar 25 9 detection detection NN cord-278511-je1509ar 25 10 of of IN cord-278511-je1509ar 25 11 remote remote JJ cord-278511-je1509ar 25 12 homologies homology NNS cord-278511-je1509ar 25 13 , , , cord-278511-je1509ar 25 14 such such JJ cord-278511-je1509ar 25 15 as as IN cord-278511-je1509ar 25 16 hidden hide VBN cord-278511-je1509ar 25 17 Markov Markov NNP cord-278511-je1509ar 25 18 models model NNS cord-278511-je1509ar 25 19 customized customize VBN cord-278511-je1509ar 25 20 for for IN cord-278511-je1509ar 25 21 viral viral JJ cord-278511-je1509ar 25 22 proteins protein NNS cord-278511-je1509ar 25 23 [ [ -LRB- cord-278511-je1509ar 25 24 10 10 CD cord-278511-je1509ar 25 25 ] ] -RRB- cord-278511-je1509ar 25 26 . . . cord-278511-je1509ar 26 1 Other other JJ cord-278511-je1509ar 26 2 machine machine NN cord-278511-je1509ar 26 3 learning learning NN cord-278511-je1509ar 26 4 strategies strategy NNS cord-278511-je1509ar 26 5 may may MD cord-278511-je1509ar 26 6 include include VB cord-278511-je1509ar 26 7 development development NN cord-278511-je1509ar 26 8 of of IN cord-278511-je1509ar 26 9 primary primary JJ cord-278511-je1509ar 26 10 sequence sequence NN cord-278511-je1509ar 26 11 - - HYPH cord-278511-je1509ar 26 12 alignment alignment NN cord-278511-je1509ar 26 13 - - HYPH cord-278511-je1509ar 26 14 independent independent JJ cord-278511-je1509ar 26 15 classification classification NN cord-278511-je1509ar 26 16 approaches approach NNS cord-278511-je1509ar 26 17 [ [ -LRB- cord-278511-je1509ar 26 18 11 11 CD cord-278511-je1509ar 26 19 ] ] -RRB- cord-278511-je1509ar 26 20 or or CC cord-278511-je1509ar 26 21 development development NN cord-278511-je1509ar 26 22 of of IN cord-278511-je1509ar 26 23 artificial artificial JJ cord-278511-je1509ar 26 24 neural neural JJ cord-278511-je1509ar 26 25 networks network NNS cord-278511-je1509ar 26 26 [ [ -LRB- cord-278511-je1509ar 26 27 12 12 CD cord-278511-je1509ar 26 28 ] ] -RRB- cord-278511-je1509ar 26 29 . . . cord-278511-je1509ar 27 1 Experimentally experimentally RB cord-278511-je1509ar 27 2 , , , cord-278511-je1509ar 27 3 as as IN cord-278511-je1509ar 27 4 described describe VBN cord-278511-je1509ar 27 5 below below RB cord-278511-je1509ar 27 6 , , , cord-278511-je1509ar 27 7 expanding expand VBG cord-278511-je1509ar 27 8 the the DT cord-278511-je1509ar 27 9 set set NN cord-278511-je1509ar 27 10 of of IN cord-278511-je1509ar 27 11 culturable culturable JJ cord-278511-je1509ar 27 12 viruses virus NNS cord-278511-je1509ar 27 13 will will MD cord-278511-je1509ar 27 14 provide provide VB cord-278511-je1509ar 27 15 additional additional JJ cord-278511-je1509ar 27 16 reference reference NN cord-278511-je1509ar 27 17 sequences sequence NNS cord-278511-je1509ar 27 18 that that WDT cord-278511-je1509ar 27 19 should should MD cord-278511-je1509ar 27 20 also also RB cord-278511-je1509ar 27 21 decrease decrease VB cord-278511-je1509ar 27 22 the the DT cord-278511-je1509ar 27 23 amount amount NN cord-278511-je1509ar 27 24 of of IN cord-278511-je1509ar 27 25 viral viral JJ cord-278511-je1509ar 27 26 dark dark JJ cord-278511-je1509ar 27 27 matter matter NN cord-278511-je1509ar 27 28 . . . cord-278511-je1509ar 28 1 One one CD cord-278511-je1509ar 28 2 bias bias NN cord-278511-je1509ar 28 3 in in IN cord-278511-je1509ar 28 4 many many JJ cord-278511-je1509ar 28 5 virome virome JJ cord-278511-je1509ar 28 6 studies study NNS cord-278511-je1509ar 28 7 to to IN cord-278511-je1509ar 28 8 date date NN cord-278511-je1509ar 28 9 is be VBZ cord-278511-je1509ar 28 10 a a DT cord-278511-je1509ar 28 11 focus focus NN cord-278511-je1509ar 28 12 only only RB cord-278511-je1509ar 28 13 on on IN cord-278511-je1509ar 28 14 sequencing sequencing NN cord-278511-je1509ar 28 15 of of IN cord-278511-je1509ar 28 16 DNA dna NN cord-278511-je1509ar 28 17 . . . cord-278511-je1509ar 29 1 This this DT cord-278511-je1509ar 29 2 is be VBZ cord-278511-je1509ar 29 3 due due JJ cord-278511-je1509ar 29 4 in in IN cord-278511-je1509ar 29 5 part part NN cord-278511-je1509ar 29 6 to to IN cord-278511-je1509ar 29 7 the the DT cord-278511-je1509ar 29 8 bacterial bacterial JJ cord-278511-je1509ar 29 9 microbiome microbiome NN cord-278511-je1509ar 29 10 being be VBG cord-278511-je1509ar 29 11 the the DT cord-278511-je1509ar 29 12 primary primary JJ cord-278511-je1509ar 29 13 driver driver NN cord-278511-je1509ar 29 14 of of IN cord-278511-je1509ar 29 15 many many JJ cord-278511-je1509ar 29 16 studies study NNS cord-278511-je1509ar 29 17 , , , cord-278511-je1509ar 29 18 and and CC cord-278511-je1509ar 29 19 thus thus RB cord-278511-je1509ar 29 20 at at IN cord-278511-je1509ar 29 21 the the DT cord-278511-je1509ar 29 22 time time NN cord-278511-je1509ar 29 23 of of IN cord-278511-je1509ar 29 24 sampling sampling NN cord-278511-je1509ar 29 25 , , , cord-278511-je1509ar 29 26 experimental experimental JJ cord-278511-je1509ar 29 27 measures measure NNS cord-278511-je1509ar 29 28 to to TO cord-278511-je1509ar 29 29 extract extract VB cord-278511-je1509ar 29 30 DNA DNA NNP cord-278511-je1509ar 29 31 were be VBD cord-278511-je1509ar 29 32 employed employ VBN cord-278511-je1509ar 29 33 without without IN cord-278511-je1509ar 29 34 regard regard NN cord-278511-je1509ar 29 35 to to IN cord-278511-je1509ar 29 36 trying try VBG cord-278511-je1509ar 29 37 to to TO cord-278511-je1509ar 29 38 either either CC cord-278511-je1509ar 29 39 preserve preserve VB cord-278511-je1509ar 29 40 or or CC cord-278511-je1509ar 29 41 recover recover VB cord-278511-je1509ar 29 42 the the DT cord-278511-je1509ar 29 43 RNA RNA NNP cord-278511-je1509ar 29 44 . . . cord-278511-je1509ar 30 1 In in IN cord-278511-je1509ar 30 2 addition addition NN cord-278511-je1509ar 30 3 , , , cord-278511-je1509ar 30 4 some some DT cord-278511-je1509ar 30 5 studies study NNS cord-278511-je1509ar 30 6 utilize utilize VBP cord-278511-je1509ar 30 7 DNA dna NN cord-278511-je1509ar 30 8 - - HYPH cord-278511-je1509ar 30 9 specific specific JJ cord-278511-je1509ar 30 10 amplification amplification NN cord-278511-je1509ar 30 11 strategies strategy NNS cord-278511-je1509ar 30 12 such such JJ cord-278511-je1509ar 30 13 as as IN cord-278511-je1509ar 30 14 phi29-mediated phi29-mediated JJ cord-278511-je1509ar 30 15 whole whole JJ cord-278511-je1509ar 30 16 - - HYPH cord-278511-je1509ar 30 17 genome genome NN cord-278511-je1509ar 30 18 amplification amplification NN cord-278511-je1509ar 30 19 . . . cord-278511-je1509ar 31 1 These these DT cord-278511-je1509ar 31 2 studies study NNS cord-278511-je1509ar 31 3 are be VBP cord-278511-je1509ar 31 4 unable unable JJ cord-278511-je1509ar 31 5 to to TO cord-278511-je1509ar 31 6 assess assess VB cord-278511-je1509ar 31 7 the the DT cord-278511-je1509ar 31 8 RNA RNA NNP cord-278511-je1509ar 31 9 component component NN cord-278511-je1509ar 31 10 of of IN cord-278511-je1509ar 31 11 the the DT cord-278511-je1509ar 31 12 virome virome NN cord-278511-je1509ar 31 13 . . . cord-278511-je1509ar 32 1 Yet yet RB cord-278511-je1509ar 32 2 the the DT cord-278511-je1509ar 32 3 majority majority NN cord-278511-je1509ar 32 4 of of IN cord-278511-je1509ar 32 5 the the DT cord-278511-je1509ar 32 6 known know VBN cord-278511-je1509ar 32 7 eukaryotic eukaryotic JJ cord-278511-je1509ar 32 8 viral viral JJ cord-278511-je1509ar 32 9 denizens denizen NNS cord-278511-je1509ar 32 10 of of IN cord-278511-je1509ar 32 11 the the DT cord-278511-je1509ar 32 12 human human JJ cord-278511-je1509ar 32 13 enteric enteric JJ cord-278511-je1509ar 32 14 tract tract NN cord-278511-je1509ar 32 15 are be VBP cord-278511-je1509ar 32 16 RNA RNA NNP cord-278511-je1509ar 32 17 viruses virus NNS cord-278511-je1509ar 32 18 , , , cord-278511-je1509ar 32 19 such such JJ cord-278511-je1509ar 32 20 as as IN cord-278511-je1509ar 32 21 enteroviruses enteroviruses NNP cord-278511-je1509ar 32 22 , , , cord-278511-je1509ar 32 23 rotaviruses rotaviruses NNP cord-278511-je1509ar 32 24 , , , cord-278511-je1509ar 32 25 noroviruses noroviruses NNP cord-278511-je1509ar 32 26 , , , cord-278511-je1509ar 32 27 and and CC cord-278511-je1509ar 32 28 astroviruses astroviruse NNS cord-278511-je1509ar 32 29 . . . cord-278511-je1509ar 33 1 On on IN cord-278511-je1509ar 33 2 the the DT cord-278511-je1509ar 33 3 phage phage NN cord-278511-je1509ar 33 4 side side NN cord-278511-je1509ar 33 5 , , , cord-278511-je1509ar 33 6 while while IN cord-278511-je1509ar 33 7 it -PRON- PRP cord-278511-je1509ar 33 8 is be VBZ cord-278511-je1509ar 33 9 true true JJ cord-278511-je1509ar 33 10 that that IN cord-278511-je1509ar 33 11 the the DT cord-278511-je1509ar 33 12 vast vast JJ cord-278511-je1509ar 33 13 majority majority NN cord-278511-je1509ar 33 14 of of IN cord-278511-je1509ar 33 15 known know VBN cord-278511-je1509ar 33 16 phages phage NNS cord-278511-je1509ar 33 17 have have VBP cord-278511-je1509ar 33 18 DNA dna NN cord-278511-je1509ar 33 19 genomes genome NNS cord-278511-je1509ar 33 20 , , , cord-278511-je1509ar 33 21 the the DT cord-278511-je1509ar 33 22 bias bias NN cord-278511-je1509ar 33 23 of of IN cord-278511-je1509ar 33 24 sequencing sequence VBG cord-278511-je1509ar 33 25 exclusively exclusively RB cord-278511-je1509ar 33 26 DNA DNA NNP cord-278511-je1509ar 33 27 has have VBZ cord-278511-je1509ar 33 28 served serve VBN cord-278511-je1509ar 33 29 as as IN cord-278511-je1509ar 33 30 a a DT cord-278511-je1509ar 33 31 self self NN cord-278511-je1509ar 33 32 - - HYPH cord-278511-je1509ar 33 33 reinforcing reinforce VBG cord-278511-je1509ar 33 34 positive positive JJ cord-278511-je1509ar 33 35 feedback feedback NN cord-278511-je1509ar 33 36 loop loop NN cord-278511-je1509ar 33 37 ; ; : cord-278511-je1509ar 33 38 however however RB cord-278511-je1509ar 33 39 , , , cord-278511-je1509ar 33 40 recent recent JJ cord-278511-je1509ar 33 41 studies study NNS cord-278511-je1509ar 33 42 examining examine VBG cord-278511-je1509ar 33 43 samples sample NNS cord-278511-je1509ar 33 44 that that WDT cord-278511-je1509ar 33 45 have have VBP cord-278511-je1509ar 33 46 sequenced sequence VBN cord-278511-je1509ar 33 47 RNA RNA NNP cord-278511-je1509ar 33 48 have have VBP cord-278511-je1509ar 33 49 demonstrated demonstrate VBN cord-278511-je1509ar 33 50 that that IN cord-278511-je1509ar 33 51 there there EX cord-278511-je1509ar 33 52 is be VBZ cord-278511-je1509ar 33 53 a a DT cord-278511-je1509ar 33 54 much much RB cord-278511-je1509ar 33 55 greater great JJR cord-278511-je1509ar 33 56 abundance abundance NN cord-278511-je1509ar 33 57 and and CC cord-278511-je1509ar 33 58 diversity diversity NN cord-278511-je1509ar 33 59 of of IN cord-278511-je1509ar 33 60 RNA RNA NNP cord-278511-je1509ar 33 61 phages phage NNS cord-278511-je1509ar 33 62 in in IN cord-278511-je1509ar 33 63 the the DT cord-278511-je1509ar 33 64 world world NN cord-278511-je1509ar 33 65 [ [ -LRB- cord-278511-je1509ar 33 66 13 13 CD cord-278511-je1509ar 33 67 ] ] -RRB- cord-278511-je1509ar 33 68 . . . cord-278511-je1509ar 34 1 Thus thus RB cord-278511-je1509ar 34 2 , , , cord-278511-je1509ar 34 3 in in IN cord-278511-je1509ar 34 4 order order NN cord-278511-je1509ar 34 5 achieve achieve VB cord-278511-je1509ar 34 6 a a DT cord-278511-je1509ar 34 7 more more RBR cord-278511-je1509ar 34 8 complete complete JJ cord-278511-je1509ar 34 9 view view NN cord-278511-je1509ar 34 10 of of IN cord-278511-je1509ar 34 11 the the DT cord-278511-je1509ar 34 12 virome virome NN cord-278511-je1509ar 34 13 , , , cord-278511-je1509ar 34 14 it -PRON- PRP cord-278511-je1509ar 34 15 is be VBZ cord-278511-je1509ar 34 16 critical critical JJ cord-278511-je1509ar 34 17 that that IN cord-278511-je1509ar 34 18 virome virome NNP cord-278511-je1509ar 34 19 studies study NNS cord-278511-je1509ar 34 20 be be VB cord-278511-je1509ar 34 21 designed design VBN cord-278511-je1509ar 34 22 such such PDT cord-278511-je1509ar 34 23 that that IN cord-278511-je1509ar 34 24 RNA RNA NNP cord-278511-je1509ar 34 25 viruses virus NNS cord-278511-je1509ar 34 26 are be VBP cord-278511-je1509ar 34 27 preserved preserve VBN cord-278511-je1509ar 34 28 in in IN cord-278511-je1509ar 34 29 the the DT cord-278511-je1509ar 34 30 specimens specimen NNS cord-278511-je1509ar 34 31 and and CC cord-278511-je1509ar 34 32 that that IN cord-278511-je1509ar 34 33 the the DT cord-278511-je1509ar 34 34 RNA RNA NNP cord-278511-je1509ar 34 35 fraction fraction NN cord-278511-je1509ar 34 36 is be VBZ cord-278511-je1509ar 34 37 incorporated incorporate VBN cord-278511-je1509ar 34 38 into into IN cord-278511-je1509ar 34 39 the the DT cord-278511-je1509ar 34 40 sequencing sequencing NN cord-278511-je1509ar 34 41 and and CC cord-278511-je1509ar 34 42 analysis analysis NN cord-278511-je1509ar 34 43 . . . cord-278511-je1509ar 35 1 The the DT cord-278511-je1509ar 35 2 advent advent NN cord-278511-je1509ar 35 3 of of IN cord-278511-je1509ar 35 4 metagenomics metagenomic NNS cord-278511-je1509ar 35 5 has have VBZ cord-278511-je1509ar 35 6 greatly greatly RB cord-278511-je1509ar 35 7 enhanced enhance VBN cord-278511-je1509ar 35 8 our -PRON- PRP$ cord-278511-je1509ar 35 9 ability ability NN cord-278511-je1509ar 35 10 to to TO cord-278511-je1509ar 35 11 detect detect VB cord-278511-je1509ar 35 12 known know VBN cord-278511-je1509ar 35 13 and and CC cord-278511-je1509ar 35 14 novel novel JJ cord-278511-je1509ar 35 15 viral viral JJ cord-278511-je1509ar 35 16 sequences sequence NNS cord-278511-je1509ar 35 17 in in IN cord-278511-je1509ar 35 18 unbiased unbiased JJ cord-278511-je1509ar 35 19 fashion fashion NN cord-278511-je1509ar 35 20 and and CC cord-278511-je1509ar 35 21 to to TO cord-278511-je1509ar 35 22 establish establish VB cord-278511-je1509ar 35 23 novel novel JJ cord-278511-je1509ar 35 24 associations association NNS cord-278511-je1509ar 35 25 of of IN cord-278511-je1509ar 35 26 these these DT cord-278511-je1509ar 35 27 sequences sequence NNS cord-278511-je1509ar 35 28 with with IN cord-278511-je1509ar 35 29 various various JJ cord-278511-je1509ar 35 30 disease disease NN cord-278511-je1509ar 35 31 [ [ -LRB- cord-278511-je1509ar 35 32 1 1 CD cord-278511-je1509ar 35 33 ] ] -RRB- cord-278511-je1509ar 35 34 [ [ -LRB- cord-278511-je1509ar 35 35 2 2 CD cord-278511-je1509ar 35 36 ] ] -RRB- cord-278511-je1509ar 35 37 [ [ -LRB- cord-278511-je1509ar 35 38 3 3 CD cord-278511-je1509ar 35 39 ] ] -RRB- cord-278511-je1509ar 35 40 [ [ -LRB- cord-278511-je1509ar 35 41 4 4 CD cord-278511-je1509ar 35 42 ] ] -RRB- cord-278511-je1509ar 35 43 [ [ -LRB- cord-278511-je1509ar 35 44 5 5 CD cord-278511-je1509ar 35 45 ] ] -RRB- cord-278511-je1509ar 35 46 [ [ -LRB- cord-278511-je1509ar 35 47 6 6 CD cord-278511-je1509ar 35 48 ] ] -RRB- cord-278511-je1509ar 35 49 [ [ -LRB- cord-278511-je1509ar 35 50 7 7 CD cord-278511-je1509ar 35 51 ] ] -RRB- cord-278511-je1509ar 35 52 . . . cord-278511-je1509ar 36 1 However however RB cord-278511-je1509ar 36 2 , , , cord-278511-je1509ar 36 3 it -PRON- PRP cord-278511-je1509ar 36 4 is be VBZ cord-278511-je1509ar 36 5 not not RB cord-278511-je1509ar 36 6 known know VBN cord-278511-je1509ar 36 7 whether whether IN cord-278511-je1509ar 36 8 the the DT cord-278511-je1509ar 36 9 virome virome NN cord-278511-je1509ar 36 10 plays play VBZ cord-278511-je1509ar 36 11 a a DT cord-278511-je1509ar 36 12 causative causative JJ cord-278511-je1509ar 36 13 role role NN cord-278511-je1509ar 36 14 or or CC cord-278511-je1509ar 36 15 not not RB cord-278511-je1509ar 36 16 . . . cord-278511-je1509ar 37 1 Koch Koch NNP cord-278511-je1509ar 37 2 's 's POS cord-278511-je1509ar 37 3 postulates postulate NNS cord-278511-je1509ar 37 4 remain remain VBP cord-278511-je1509ar 37 5 the the DT cord-278511-je1509ar 37 6 gold gold NN cord-278511-je1509ar 37 7 standard standard NN cord-278511-je1509ar 37 8 for for IN cord-278511-je1509ar 37 9 microbial microbial JJ cord-278511-je1509ar 37 10 disease disease NN cord-278511-je1509ar 37 11 causality causality NN cord-278511-je1509ar 37 12 , , , cord-278511-je1509ar 37 13 and and CC cord-278511-je1509ar 37 14 thus thus RB cord-278511-je1509ar 37 15 the the DT cord-278511-je1509ar 37 16 first first JJ cord-278511-je1509ar 37 17 step step NN cord-278511-je1509ar 37 18 is be VBZ cord-278511-je1509ar 37 19 to to TO cord-278511-je1509ar 37 20 establish establish VB cord-278511-je1509ar 37 21 culture culture NN cord-278511-je1509ar 37 22 systems system NNS cord-278511-je1509ar 37 23 for for IN cord-278511-je1509ar 37 24 viruses virus NNS cord-278511-je1509ar 37 25 associated associate VBN cord-278511-je1509ar 37 26 with with IN cord-278511-je1509ar 37 27 the the DT cord-278511-je1509ar 37 28 disease disease NN cord-278511-je1509ar 37 29 of of IN cord-278511-je1509ar 37 30 interest interest NN cord-278511-je1509ar 37 31 . . . cord-278511-je1509ar 38 1 The the DT cord-278511-je1509ar 38 2 lack lack NN cord-278511-je1509ar 38 3 of of IN cord-278511-je1509ar 38 4 culture culture NN cord-278511-je1509ar 38 5 systems system NNS cord-278511-je1509ar 38 6 for for IN cord-278511-je1509ar 38 7 viruses virus NNS cord-278511-je1509ar 38 8 identified identify VBN cord-278511-je1509ar 38 9 in in IN cord-278511-je1509ar 38 10 virome virome NNP cord-278511-je1509ar 38 11 studies study NNS cord-278511-je1509ar 38 12 , , , cord-278511-je1509ar 38 13 for for IN cord-278511-je1509ar 38 14 both both DT cord-278511-je1509ar 38 15 eukaryotic eukaryotic JJ cord-278511-je1509ar 38 16 viruses virus NNS cord-278511-je1509ar 38 17 and and CC cord-278511-je1509ar 38 18 phages phage NNS cord-278511-je1509ar 38 19 , , , cord-278511-je1509ar 38 20 is be VBZ cord-278511-je1509ar 38 21 pronounced pronounce VBN cord-278511-je1509ar 38 22 . . . cord-278511-je1509ar 39 1 As as IN cord-278511-je1509ar 39 2 an an DT cord-278511-je1509ar 39 3 example example NN cord-278511-je1509ar 39 4 , , , cord-278511-je1509ar 39 5 although although IN cord-278511-je1509ar 39 6 dozens dozen NNS cord-278511-je1509ar 39 7 of of IN cord-278511-je1509ar 39 8 novel novel JJ cord-278511-je1509ar 39 9 eukaryotic eukaryotic JJ cord-278511-je1509ar 39 10 viruses virus NNS cord-278511-je1509ar 39 11 have have VBP cord-278511-je1509ar 39 12 been be VBN cord-278511-je1509ar 39 13 identified identify VBN cord-278511-je1509ar 39 14 in in IN cord-278511-je1509ar 39 15 the the DT cord-278511-je1509ar 39 16 mammalian mammalian JJ cord-278511-je1509ar 39 17 enteric enteric JJ cord-278511-je1509ar 39 18 tract tract NN cord-278511-je1509ar 39 19 by by IN cord-278511-je1509ar 39 20 metagenomic metagenomic JJ cord-278511-je1509ar 39 21 sequencing sequencing NN cord-278511-je1509ar 39 22 , , , cord-278511-je1509ar 39 23 culture culture NN cord-278511-je1509ar 39 24 systems system NNS cord-278511-je1509ar 39 25 for for IN cord-278511-je1509ar 39 26 only only RB cord-278511-je1509ar 39 27 a a DT cord-278511-je1509ar 39 28 very very RB cord-278511-je1509ar 39 29 limited limited JJ cord-278511-je1509ar 39 30 number number NN cord-278511-je1509ar 39 31 have have VBP cord-278511-je1509ar 39 32 been be VBN cord-278511-je1509ar 39 33 described describe VBN cord-278511-je1509ar 39 34 to to IN cord-278511-je1509ar 39 35 date date NN cord-278511-je1509ar 39 36 [ [ -LRB- cord-278511-je1509ar 39 37 14 14 CD cord-278511-je1509ar 39 38 , , , cord-278511-je1509ar 39 39 15 15 CD cord-278511-je1509ar 39 40 ] ] -RRB- cord-278511-je1509ar 39 41 . . . cord-278511-je1509ar 40 1 Likewise likewise RB cord-278511-je1509ar 40 2 , , , cord-278511-je1509ar 40 3 for for IN cord-278511-je1509ar 40 4 phages phage NNS cord-278511-je1509ar 40 5 , , , cord-278511-je1509ar 40 6 genomic genomic JJ cord-278511-je1509ar 40 7 sequences sequence NNS cord-278511-je1509ar 40 8 of of IN cord-278511-je1509ar 40 9 thousands thousand NNS cord-278511-je1509ar 40 10 of of IN cord-278511-je1509ar 40 11 novel novel NN cord-278511-je1509ar 40 12 phages phage NNS cord-278511-je1509ar 40 13 can can MD cord-278511-je1509ar 40 14 be be VB cord-278511-je1509ar 40 15 identified identify VBN cord-278511-je1509ar 40 16 in in IN cord-278511-je1509ar 40 17 a a DT cord-278511-je1509ar 40 18 single single JJ cord-278511-je1509ar 40 19 study study NN cord-278511-je1509ar 40 20 [ [ -LRB- cord-278511-je1509ar 40 21 16 16 CD cord-278511-je1509ar 40 22 , , , cord-278511-je1509ar 40 23 17 17 CD cord-278511-je1509ar 40 24 ] ] -RRB- cord-278511-je1509ar 40 25 , , , cord-278511-je1509ar 40 26 but but CC cord-278511-je1509ar 40 27 very very RB cord-278511-je1509ar 40 28 few few JJ cord-278511-je1509ar 40 29 have have VBP cord-278511-je1509ar 40 30 been be VBN cord-278511-je1509ar 40 31 isolated isolate VBN cord-278511-je1509ar 40 32 [ [ -LRB- cord-278511-je1509ar 40 33 18 18 CD cord-278511-je1509ar 40 34 ] ] -RRB- cord-278511-je1509ar 40 35 . . . cord-278511-je1509ar 41 1 Thus thus RB cord-278511-je1509ar 41 2 , , , cord-278511-je1509ar 41 3 while while IN cord-278511-je1509ar 41 4 ( ( -LRB- cord-278511-je1509ar 41 5 in in IN cord-278511-je1509ar 41 6 the the DT cord-278511-je1509ar 41 7 past past NN cord-278511-je1509ar 41 8 ) ) -RRB- cord-278511-je1509ar 41 9 discovery discovery NN cord-278511-je1509ar 41 10 of of IN cord-278511-je1509ar 41 11 novel novel NN cord-278511-je1509ar 41 12 viruses virus NNS cord-278511-je1509ar 41 13 was be VBD cord-278511-je1509ar 41 14 rate rate NN cord-278511-je1509ar 41 15 limiting limit VBG cord-278511-je1509ar 41 16 , , , cord-278511-je1509ar 41 17 today today NN cord-278511-je1509ar 41 18 the the DT cord-278511-je1509ar 41 19 rate rate NN cord-278511-je1509ar 41 20 - - HYPH cord-278511-je1509ar 41 21 limiting limit VBG cord-278511-je1509ar 41 22 step step NN cord-278511-je1509ar 41 23 has have VBZ cord-278511-je1509ar 41 24 shifted shift VBN cord-278511-je1509ar 41 25 to to IN cord-278511-je1509ar 41 26 development development NN cord-278511-je1509ar 41 27 of of IN cord-278511-je1509ar 41 28 culture culture NN cord-278511-je1509ar 41 29 systems system NNS cord-278511-je1509ar 41 30 for for IN cord-278511-je1509ar 41 31 the the DT cord-278511-je1509ar 41 32 viruses virus NNS cord-278511-je1509ar 41 33 that that WDT cord-278511-je1509ar 41 34 have have VBP cord-278511-je1509ar 41 35 been be VBN cord-278511-je1509ar 41 36 molecularly molecularly RB cord-278511-je1509ar 41 37 identified identify VBN cord-278511-je1509ar 41 38 . . . cord-278511-je1509ar 42 1 How how WRB cord-278511-je1509ar 42 2 can can MD cord-278511-je1509ar 42 3 this this DT cord-278511-je1509ar 42 4 be be VB cord-278511-je1509ar 42 5 addressed address VBN cord-278511-je1509ar 42 6 ? ? . cord-278511-je1509ar 43 1 To to IN cord-278511-je1509ar 43 2 some some DT cord-278511-je1509ar 43 3 extent extent NN cord-278511-je1509ar 43 4 , , , cord-278511-je1509ar 43 5 this this DT cord-278511-je1509ar 43 6 is be VBZ cord-278511-je1509ar 43 7 simply simply RB cord-278511-je1509ar 43 8 a a DT cord-278511-je1509ar 43 9 matter matter NN cord-278511-je1509ar 43 10 of of IN cord-278511-je1509ar 43 11 effort effort NN cord-278511-je1509ar 43 12 . . . cord-278511-je1509ar 44 1 In in IN cord-278511-je1509ar 44 2 all all DT cord-278511-je1509ar 44 3 likelihood likelihood NN cord-278511-je1509ar 44 4 , , , cord-278511-je1509ar 44 5 no no DT cord-278511-je1509ar 44 6 effort effort NN cord-278511-je1509ar 44 7 has have VBZ cord-278511-je1509ar 44 8 been be VBN cord-278511-je1509ar 44 9 made make VBN cord-278511-je1509ar 44 10 to to TO cord-278511-je1509ar 44 11 culture culture VB cord-278511-je1509ar 44 12 the the DT cord-278511-je1509ar 44 13 vast vast JJ cord-278511-je1509ar 44 14 majority majority NN cord-278511-je1509ar 44 15 of of IN cord-278511-je1509ar 44 16 the the DT cord-278511-je1509ar 44 17 novel novel NN cord-278511-je1509ar 44 18 viruses virus NNS cord-278511-je1509ar 44 19 identified identify VBN cord-278511-je1509ar 44 20 in in IN cord-278511-je1509ar 44 21 virome virome NNP cord-278511-je1509ar 44 22 studies study NNS cord-278511-je1509ar 44 23 , , , cord-278511-je1509ar 44 24 and and CC cord-278511-je1509ar 44 25 some some DT cord-278511-je1509ar 44 26 will will MD cord-278511-je1509ar 44 27 surely surely RB cord-278511-je1509ar 44 28 succumb succumb VB cord-278511-je1509ar 44 29 to to IN cord-278511-je1509ar 44 30 standard standard JJ cord-278511-je1509ar 44 31 culture culture NN cord-278511-je1509ar 44 32 conditions condition NNS cord-278511-je1509ar 44 33 once once RB cord-278511-je1509ar 44 34 applied apply VBD cord-278511-je1509ar 44 35 . . . cord-278511-je1509ar 45 1 Limitations limitation NNS cord-278511-je1509ar 45 2 in in IN cord-278511-je1509ar 45 3 quantity quantity NN cord-278511-je1509ar 45 4 or or CC cord-278511-je1509ar 45 5 quality quality NN cord-278511-je1509ar 45 6 of of IN cord-278511-je1509ar 45 7 primary primary JJ cord-278511-je1509ar 45 8 specimens specimen NNS cord-278511-je1509ar 45 9 containing contain VBG cord-278511-je1509ar 45 10 viable viable JJ cord-278511-je1509ar 45 11 virus virus NN cord-278511-je1509ar 45 12 can can MD cord-278511-je1509ar 45 13 contribute contribute VB cord-278511-je1509ar 45 14 to to IN cord-278511-je1509ar 45 15 the the DT cord-278511-je1509ar 45 16 problem problem NN cord-278511-je1509ar 45 17 . . . cord-278511-je1509ar 46 1 In in IN cord-278511-je1509ar 46 2 part part NN cord-278511-je1509ar 46 3 , , , cord-278511-je1509ar 46 4 it -PRON- PRP cord-278511-je1509ar 46 5 is be VBZ cord-278511-je1509ar 46 6 challenging challenging JJ cord-278511-je1509ar 46 7 for for IN cord-278511-je1509ar 46 8 labs lab NNS cord-278511-je1509ar 46 9 to to TO cord-278511-je1509ar 46 10 obtain obtain VB cord-278511-je1509ar 46 11 funding funding NN cord-278511-je1509ar 46 12 to to IN cord-278511-je1509ar 46 13 culture culture NN cord-278511-je1509ar 46 14 novel novel NN cord-278511-je1509ar 46 15 viruses virus NNS cord-278511-je1509ar 46 16 , , , cord-278511-je1509ar 46 17 particularly particularly RB cord-278511-je1509ar 46 18 in in IN cord-278511-je1509ar 46 19 the the DT cord-278511-je1509ar 46 20 absence absence NN cord-278511-je1509ar 46 21 of of IN cord-278511-je1509ar 46 22 any any DT cord-278511-je1509ar 46 23 strong strong JJ cord-278511-je1509ar 46 24 disease disease NNP cord-278511-je1509ar 46 25 association association NNP cord-278511-je1509ar 46 26 . . . cord-278511-je1509ar 47 1 Moreover moreover RB cord-278511-je1509ar 47 2 , , , cord-278511-je1509ar 47 3 the the DT cord-278511-je1509ar 47 4 risk risk NN cord-278511-je1509ar 47 5 of of IN cord-278511-je1509ar 47 6 a a DT cord-278511-je1509ar 47 7 negative negative JJ cord-278511-je1509ar 47 8 result result NN cord-278511-je1509ar 47 9 , , , cord-278511-je1509ar 47 10 exemplified exemplify VBN cord-278511-je1509ar 47 11 by by IN cord-278511-je1509ar 47 12 many many JJ cord-278511-je1509ar 47 13 decades decade NNS cord-278511-je1509ar 47 14 of of IN cord-278511-je1509ar 47 15 unsuccessful unsuccessful JJ cord-278511-je1509ar 47 16 attempts attempt NNS cord-278511-je1509ar 47 17 to to TO cord-278511-je1509ar 47 18 culture culture VB cord-278511-je1509ar 47 19 human human JJ cord-278511-je1509ar 47 20 norovirus norovirus NN cord-278511-je1509ar 47 21 , , , cord-278511-je1509ar 47 22 is be VBZ cord-278511-je1509ar 47 23 substantial substantial JJ cord-278511-je1509ar 47 24 . . . cord-278511-je1509ar 48 1 Nonetheless nonetheless RB cord-278511-je1509ar 48 2 , , , cord-278511-je1509ar 48 3 given give VBN cord-278511-je1509ar 48 4 that that IN cord-278511-je1509ar 48 5 the the DT cord-278511-je1509ar 48 6 lack lack NN cord-278511-je1509ar 48 7 of of IN cord-278511-je1509ar 48 8 ability ability NN cord-278511-je1509ar 48 9 to to TO cord-278511-je1509ar 48 10 culture culture VB cord-278511-je1509ar 48 11 a a DT cord-278511-je1509ar 48 12 virus virus NN cord-278511-je1509ar 48 13 is be VBZ cord-278511-je1509ar 48 14 perhaps perhaps RB cord-278511-je1509ar 48 15 the the DT cord-278511-je1509ar 48 16 most most RBS cord-278511-je1509ar 48 17 fundamental fundamental JJ cord-278511-je1509ar 48 18 barrier barrier NN cord-278511-je1509ar 48 19 to to TO cord-278511-je1509ar 48 20 progress progress VB cord-278511-je1509ar 48 21 in in IN cord-278511-je1509ar 48 22 the the DT cord-278511-je1509ar 48 23 study study NN cord-278511-je1509ar 48 24 of of IN cord-278511-je1509ar 48 25 that that DT cord-278511-je1509ar 48 26 virus virus NN cord-278511-je1509ar 48 27 , , , cord-278511-je1509ar 48 28 dedicated dedicated JJ cord-278511-je1509ar 48 29 efforts effort NNS cord-278511-je1509ar 48 30 to to TO cord-278511-je1509ar 48 31 develop develop VB cord-278511-je1509ar 48 32 culture culture NN cord-278511-je1509ar 48 33 systems system NNS cord-278511-je1509ar 48 34 are be VBP cord-278511-je1509ar 48 35 absolutely absolutely RB cord-278511-je1509ar 48 36 necessary necessary JJ cord-278511-je1509ar 48 37 . . . cord-278511-je1509ar 49 1 For for IN cord-278511-je1509ar 49 2 some some DT cord-278511-je1509ar 49 3 of of IN cord-278511-je1509ar 49 4 the the DT cord-278511-je1509ar 49 5 more more RBR cord-278511-je1509ar 49 6 recently recently RB cord-278511-je1509ar 49 7 discovered discover VBN cord-278511-je1509ar 49 8 eukaryotic eukaryotic JJ cord-278511-je1509ar 49 9 viruses virus NNS cord-278511-je1509ar 49 10 , , , cord-278511-je1509ar 49 11 the the DT cord-278511-je1509ar 49 12 advent advent NN cord-278511-je1509ar 49 13 of of IN cord-278511-je1509ar 49 14 primary primary JJ cord-278511-je1509ar 49 15 , , , cord-278511-je1509ar 49 16 differentiated differentiated JJ cord-278511-je1509ar 49 17 culture culture NN cord-278511-je1509ar 49 18 systems system NNS cord-278511-je1509ar 49 19 has have VBZ cord-278511-je1509ar 49 20 been be VBN cord-278511-je1509ar 49 21 key key JJ cord-278511-je1509ar 49 22 to to IN cord-278511-je1509ar 49 23 unlocking unlock VBG cord-278511-je1509ar 49 24 this this DT cord-278511-je1509ar 49 25 riddle riddle NN cord-278511-je1509ar 49 26 . . . cord-278511-je1509ar 50 1 For for IN cord-278511-je1509ar 50 2 example example NN cord-278511-je1509ar 50 3 , , , cord-278511-je1509ar 50 4 the the DT cord-278511-je1509ar 50 5 respiratory respiratory JJ cord-278511-je1509ar 50 6 viruses virus NNS cord-278511-je1509ar 50 7 bocavirus bocavirus NNP cord-278511-je1509ar 50 8 and and CC cord-278511-je1509ar 50 9 coronavirus coronavirus NN cord-278511-je1509ar 50 10 HKU1 HKU1 NNP cord-278511-je1509ar 50 11 can can MD cord-278511-je1509ar 50 12 be be VB cord-278511-je1509ar 50 13 propagated propagate VBN cord-278511-je1509ar 50 14 using use VBG cord-278511-je1509ar 50 15 primary primary JJ cord-278511-je1509ar 50 16 airway airway NN cord-278511-je1509ar 50 17 epithelial epithelial JJ cord-278511-je1509ar 50 18 cells cell NNS cord-278511-je1509ar 50 19 [ [ -LRB- cord-278511-je1509ar 50 20 19 19 CD cord-278511-je1509ar 50 21 , , , cord-278511-je1509ar 50 22 20 20 CD cord-278511-je1509ar 50 23 ] ] -RRB- cord-278511-je1509ar 50 24 . . . cord-278511-je1509ar 51 1 In in IN cord-278511-je1509ar 51 2 the the DT cord-278511-je1509ar 51 3 enteric enteric JJ cord-278511-je1509ar 51 4 tract tract NN cord-278511-je1509ar 51 5 , , , cord-278511-je1509ar 51 6 the the DT cord-278511-je1509ar 51 7 development development NN cord-278511-je1509ar 51 8 of of IN cord-278511-je1509ar 51 9 enteroids enteroids NNP cord-278511-je1509ar 51 10 and and CC cord-278511-je1509ar 51 11 organoids organoids NNP cord-278511-je1509ar 51 12 and and CC cord-278511-je1509ar 51 13 recognition recognition NN cord-278511-je1509ar 51 14 of of IN cord-278511-je1509ar 51 15 the the DT cord-278511-je1509ar 51 16 need need NN cord-278511-je1509ar 51 17 for for IN cord-278511-je1509ar 51 18 additional additional JJ cord-278511-je1509ar 51 19 enteric enteric JJ cord-278511-je1509ar 51 20 tract tract NN cord-278511-je1509ar 51 21 components component NNS cord-278511-je1509ar 51 22 have have VBP cord-278511-je1509ar 51 23 opened open VBN cord-278511-je1509ar 51 24 the the DT cord-278511-je1509ar 51 25 frontier frontier NN cord-278511-je1509ar 51 26 for for IN cord-278511-je1509ar 51 27 propagation propagation NN cord-278511-je1509ar 51 28 of of IN cord-278511-je1509ar 51 29 human human JJ cord-278511-je1509ar 51 30 norovirus norovirus NN cord-278511-je1509ar 51 31 [ [ -LRB- cord-278511-je1509ar 51 32 21 21 CD cord-278511-je1509ar 51 33 , , , cord-278511-je1509ar 51 34 22 22 CD cord-278511-je1509ar 51 35 ] ] -RRB- cord-278511-je1509ar 51 36 . . . cord-278511-je1509ar 52 1 Broader broad JJR cord-278511-je1509ar 52 2 application application NN cord-278511-je1509ar 52 3 of of IN cord-278511-je1509ar 52 4 these these DT cord-278511-je1509ar 52 5 systems system NNS cord-278511-je1509ar 52 6 will will MD cord-278511-je1509ar 52 7 undoubtedly undoubtedly RB cord-278511-je1509ar 52 8 lead lead VB cord-278511-je1509ar 52 9 to to IN cord-278511-je1509ar 52 10 increased increase VBN cord-278511-je1509ar 52 11 success success NN cord-278511-je1509ar 52 12 in in IN cord-278511-je1509ar 52 13 culture culture NN cord-278511-je1509ar 52 14 of of IN cord-278511-je1509ar 52 15 some some DT cord-278511-je1509ar 52 16 eukaryotic eukaryotic JJ cord-278511-je1509ar 52 17 viruses virus NNS cord-278511-je1509ar 52 18 . . . cord-278511-je1509ar 53 1 On on IN cord-278511-je1509ar 53 2 the the DT cord-278511-je1509ar 53 3 phage phage NN cord-278511-je1509ar 53 4 front front NN cord-278511-je1509ar 53 5 , , , cord-278511-je1509ar 53 6 one one CD cord-278511-je1509ar 53 7 significant significant JJ cord-278511-je1509ar 53 8 challenge challenge NN cord-278511-je1509ar 53 9 is be VBZ cord-278511-je1509ar 53 10 that that IN cord-278511-je1509ar 53 11 many many JJ cord-278511-je1509ar 53 12 of of IN cord-278511-je1509ar 53 13 the the DT cord-278511-je1509ar 53 14 bacterial bacterial JJ cord-278511-je1509ar 53 15 host host NN cord-278511-je1509ar 53 16 species specie NNS cord-278511-je1509ar 53 17 are be VBP cord-278511-je1509ar 53 18 themselves -PRON- PRP cord-278511-je1509ar 53 19 unculturable unculturable JJ cord-278511-je1509ar 53 20 using use VBG cord-278511-je1509ar 53 21 standard standard JJ cord-278511-je1509ar 53 22 bacterial bacterial JJ cord-278511-je1509ar 53 23 - - HYPH cord-278511-je1509ar 53 24 growth growth NN cord-278511-je1509ar 53 25 media medium NNS cord-278511-je1509ar 53 26 . . . cord-278511-je1509ar 54 1 Thus thus RB cord-278511-je1509ar 54 2 , , , cord-278511-je1509ar 54 3 efforts effort NNS cord-278511-je1509ar 54 4 to to TO cord-278511-je1509ar 54 5 propagate propagate VB cord-278511-je1509ar 54 6 novel novel JJ cord-278511-je1509ar 54 7 phages phage NNS cord-278511-je1509ar 54 8 will will MD cord-278511-je1509ar 54 9 also also RB cord-278511-je1509ar 54 10 entail entail VB cord-278511-je1509ar 54 11 improving improve VBG cord-278511-je1509ar 54 12 systems system NNS cord-278511-je1509ar 54 13 for for IN cord-278511-je1509ar 54 14 bacterial bacterial NN cord-278511-je1509ar 54 15 in in IN cord-278511-je1509ar 54 16 vitro vitro FW cord-278511-je1509ar 54 17 growth growth NN cord-278511-je1509ar 54 18 . . . cord-278511-je1509ar 55 1 Some some DT cord-278511-je1509ar 55 2 approaches approach NNS cord-278511-je1509ar 55 3 toward toward IN cord-278511-je1509ar 55 4 this this DT cord-278511-je1509ar 55 5 include include VBP cord-278511-je1509ar 55 6 development development NN cord-278511-je1509ar 55 7 of of IN cord-278511-je1509ar 55 8 bioreactors bioreactor NNS cord-278511-je1509ar 55 9 [ [ -LRB- cord-278511-je1509ar 55 10 23 23 CD cord-278511-je1509ar 55 11 , , , cord-278511-je1509ar 55 12 24 24 CD cord-278511-je1509ar 55 13 ] ] -RRB- cord-278511-je1509ar 55 14 and and CC cord-278511-je1509ar 55 15 other other JJ cord-278511-je1509ar 55 16 systems system NNS cord-278511-je1509ar 55 17 that that WDT cord-278511-je1509ar 55 18 better well RBR cord-278511-je1509ar 55 19 mimic mimic VBP cord-278511-je1509ar 55 20 the the DT cord-278511-je1509ar 55 21 natural natural JJ cord-278511-je1509ar 55 22 environment environment NN cord-278511-je1509ar 55 23 [ [ -LRB- cord-278511-je1509ar 55 24 25 25 CD cord-278511-je1509ar 55 25 ] ] -RRB- cord-278511-je1509ar 55 26 , , , cord-278511-je1509ar 55 27 but but CC cord-278511-je1509ar 55 28 additional additional JJ cord-278511-je1509ar 55 29 new new JJ cord-278511-je1509ar 55 30 and and CC cord-278511-je1509ar 55 31 innovative innovative JJ cord-278511-je1509ar 55 32 strategies strategy NNS cord-278511-je1509ar 55 33 are be VBP cord-278511-je1509ar 55 34 needed need VBN cord-278511-je1509ar 55 35 . . . cord-278511-je1509ar 56 1 For for IN cord-278511-je1509ar 56 2 the the DT cord-278511-je1509ar 56 3 majority majority NN cord-278511-je1509ar 56 4 of of IN cord-278511-je1509ar 56 5 complex complex JJ cord-278511-je1509ar 56 6 diseases disease NNS cord-278511-je1509ar 56 7 , , , cord-278511-je1509ar 56 8 in in IN cord-278511-je1509ar 56 9 vitro vitro FW cord-278511-je1509ar 56 10 systems system NNS cord-278511-je1509ar 56 11 are be VBP cord-278511-je1509ar 56 12 not not RB cord-278511-je1509ar 56 13 adequate adequate JJ cord-278511-je1509ar 56 14 to to TO cord-278511-je1509ar 56 15 assess assess VB cord-278511-je1509ar 56 16 viral viral JJ cord-278511-je1509ar 56 17 contributions contribution NNS cord-278511-je1509ar 56 18 to to IN cord-278511-je1509ar 56 19 pathogenicity pathogenicity NN cord-278511-je1509ar 56 20 , , , cord-278511-je1509ar 56 21 and and CC cord-278511-je1509ar 56 22 thus thus RB cord-278511-je1509ar 56 23 appropriate appropriate JJ cord-278511-je1509ar 56 24 animal animal NN cord-278511-je1509ar 56 25 - - HYPH cord-278511-je1509ar 56 26 disease disease NN cord-278511-je1509ar 56 27 models model NNS cord-278511-je1509ar 56 28 are be VBP cord-278511-je1509ar 56 29 required require VBN cord-278511-je1509ar 56 30 that that WDT cord-278511-je1509ar 56 31 also also RB cord-278511-je1509ar 56 32 reflect reflect VBP cord-278511-je1509ar 56 33 the the DT cord-278511-je1509ar 56 34 potentially potentially RB cord-278511-je1509ar 56 35 complex complex JJ cord-278511-je1509ar 56 36 interactions interaction NNS cord-278511-je1509ar 56 37 with with IN cord-278511-je1509ar 56 38 the the DT cord-278511-je1509ar 56 39 host host NN cord-278511-je1509ar 56 40 , , , cord-278511-je1509ar 56 41 bacteria bacteria NNS cord-278511-je1509ar 56 42 , , , cord-278511-je1509ar 56 43 and and CC cord-278511-je1509ar 56 44 eukaryotic eukaryotic JJ cord-278511-je1509ar 56 45 microbes microbe NNS cord-278511-je1509ar 56 46 that that WDT cord-278511-je1509ar 56 47 may may MD cord-278511-je1509ar 56 48 be be VB cord-278511-je1509ar 56 49 present present JJ cord-278511-je1509ar 56 50 . . . cord-278511-je1509ar 57 1 In in IN cord-278511-je1509ar 57 2 bacterial bacterial JJ cord-278511-je1509ar 57 3 microbiome microbiome NN cord-278511-je1509ar 57 4 studies study NNS cord-278511-je1509ar 57 5 , , , cord-278511-je1509ar 57 6 a a DT cord-278511-je1509ar 57 7 powerful powerful JJ cord-278511-je1509ar 57 8 approach approach NN cord-278511-je1509ar 57 9 has have VBZ cord-278511-je1509ar 57 10 been be VBN cord-278511-je1509ar 57 11 the the DT cord-278511-je1509ar 57 12 ability ability NN cord-278511-je1509ar 57 13 to to TO cord-278511-je1509ar 57 14 colonize colonize VB cord-278511-je1509ar 57 15 mice mouse NNS cord-278511-je1509ar 57 16 with with IN cord-278511-je1509ar 57 17 either either CC cord-278511-je1509ar 57 18 a a DT cord-278511-je1509ar 57 19 single single JJ cord-278511-je1509ar 57 20 defined define VBN cord-278511-je1509ar 57 21 bacteria bacteria NNS cord-278511-je1509ar 57 22 of of IN cord-278511-je1509ar 57 23 interest interest NN cord-278511-je1509ar 57 24 or or CC cord-278511-je1509ar 57 25 a a DT cord-278511-je1509ar 57 26 consortia consortia NN cord-278511-je1509ar 57 27 of of IN cord-278511-je1509ar 57 28 bacteria bacteria NNS cord-278511-je1509ar 57 29 . . . cord-278511-je1509ar 58 1 By by IN cord-278511-je1509ar 58 2 analogy analogy NN cord-278511-je1509ar 58 3 , , , cord-278511-je1509ar 58 4 it -PRON- PRP cord-278511-je1509ar 58 5 would would MD cord-278511-je1509ar 58 6 be be VB cord-278511-je1509ar 58 7 ideal ideal JJ cord-278511-je1509ar 58 8 if if IN cord-278511-je1509ar 58 9 the the DT cord-278511-je1509ar 58 10 virome virome NN cord-278511-je1509ar 58 11 could could MD cord-278511-je1509ar 58 12 be be VB cord-278511-je1509ar 58 13 functionally functionally RB cord-278511-je1509ar 58 14 interrogated interrogate VBN cord-278511-je1509ar 58 15 in in IN cord-278511-je1509ar 58 16 similar similar JJ cord-278511-je1509ar 58 17 fashion fashion NN cord-278511-je1509ar 58 18 . . . cord-278511-je1509ar 59 1 However however RB cord-278511-je1509ar 59 2 , , , cord-278511-je1509ar 59 3 a a DT cord-278511-je1509ar 59 4 prerequisite prerequisite NN cord-278511-je1509ar 59 5 for for IN cord-278511-je1509ar 59 6 eukaryotic eukaryotic JJ cord-278511-je1509ar 59 7 viruses virus NNS cord-278511-je1509ar 59 8 is be VBZ cord-278511-je1509ar 59 9 that that IN cord-278511-je1509ar 59 10 one one PRP cord-278511-je1509ar 59 11 must must MD cord-278511-je1509ar 59 12 first first RB cord-278511-je1509ar 59 13 be be VB cord-278511-je1509ar 59 14 able able JJ cord-278511-je1509ar 59 15 to to TO cord-278511-je1509ar 59 16 establish establish VB cord-278511-je1509ar 59 17 infection infection NN cord-278511-je1509ar 59 18 in in IN cord-278511-je1509ar 59 19 the the DT cord-278511-je1509ar 59 20 relevant relevant JJ cord-278511-je1509ar 59 21 animal animal NN cord-278511-je1509ar 59 22 model model NN cord-278511-je1509ar 59 23 . . . cord-278511-je1509ar 60 1 As as IN cord-278511-je1509ar 60 2 with with IN cord-278511-je1509ar 60 3 establishing establish VBG cord-278511-je1509ar 60 4 cell cell NN cord-278511-je1509ar 60 5 - - HYPH cord-278511-je1509ar 60 6 culture culture NN cord-278511-je1509ar 60 7 systems system NNS cord-278511-je1509ar 60 8 , , , cord-278511-je1509ar 60 9 the the DT cord-278511-je1509ar 60 10 paucity paucity NN cord-278511-je1509ar 60 11 of of IN cord-278511-je1509ar 60 12 animal animal NN cord-278511-je1509ar 60 13 - - HYPH cord-278511-je1509ar 60 14 infection infection NN cord-278511-je1509ar 60 15 models model NNS cord-278511-je1509ar 60 16 for for IN cord-278511-je1509ar 60 17 novel novel JJ cord-278511-je1509ar 60 18 viruses virus NNS cord-278511-je1509ar 60 19 stems stem VBZ cord-278511-je1509ar 60 20 in in IN cord-278511-je1509ar 60 21 part part NN cord-278511-je1509ar 60 22 from from IN cord-278511-je1509ar 60 23 lack lack NN cord-278511-je1509ar 60 24 of of IN cord-278511-je1509ar 60 25 effort effort NN cord-278511-je1509ar 60 26 to to TO cord-278511-je1509ar 60 27 develop develop VB cord-278511-je1509ar 60 28 such such JJ cord-278511-je1509ar 60 29 systems system NNS cord-278511-je1509ar 60 30 . . . cord-278511-je1509ar 61 1 Moreover moreover RB cord-278511-je1509ar 61 2 , , , cord-278511-je1509ar 61 3 the the DT cord-278511-je1509ar 61 4 challenge challenge NN cord-278511-je1509ar 61 5 is be VBZ cord-278511-je1509ar 61 6 exacerbated exacerbate VBN cord-278511-je1509ar 61 7 by by IN cord-278511-je1509ar 61 8 the the DT cord-278511-je1509ar 61 9 multitude multitude NN cord-278511-je1509ar 61 10 of of IN cord-278511-je1509ar 61 11 potential potential JJ cord-278511-je1509ar 61 12 infection infection NN cord-278511-je1509ar 61 13 routes route NNS cord-278511-je1509ar 61 14 that that WDT cord-278511-je1509ar 61 15 need need VBP cord-278511-je1509ar 61 16 to to TO cord-278511-je1509ar 61 17 be be VB cord-278511-je1509ar 61 18 evaluated evaluate VBN cord-278511-je1509ar 61 19 , , , cord-278511-je1509ar 61 20 need need VBP cord-278511-je1509ar 61 21 to to TO cord-278511-je1509ar 61 22 overcome overcome VB cord-278511-je1509ar 61 23 the the DT cord-278511-je1509ar 61 24 immune immune JJ cord-278511-je1509ar 61 25 response response NN cord-278511-je1509ar 61 26 , , , cord-278511-je1509ar 61 27 cross cross NN cord-278511-je1509ar 61 28 - - JJ cord-278511-je1509ar 61 29 species species JJ cord-278511-je1509ar 61 30 transmission transmission NN cord-278511-je1509ar 61 31 barriers barrier NNS cord-278511-je1509ar 61 32 , , , cord-278511-je1509ar 61 33 and and CC cord-278511-je1509ar 61 34 ( ( -LRB- cord-278511-je1509ar 61 35 even even RB cord-278511-je1509ar 61 36 within within IN cord-278511-je1509ar 61 37 a a DT cord-278511-je1509ar 61 38 species species NN cord-278511-je1509ar 61 39 ) ) -RRB- cord-278511-je1509ar 61 40 potential potential JJ cord-278511-je1509ar 61 41 impact impact NN cord-278511-je1509ar 61 42 of of IN cord-278511-je1509ar 61 43 varying vary VBG cord-278511-je1509ar 61 44 genetic genetic JJ cord-278511-je1509ar 61 45 backgrounds background NNS cord-278511-je1509ar 61 46 . . . cord-278511-je1509ar 62 1 Use use NN cord-278511-je1509ar 62 2 of of IN cord-278511-je1509ar 62 3 transgenic transgenic JJ cord-278511-je1509ar 62 4 animals animal NNS cord-278511-je1509ar 62 5 that that WDT cord-278511-je1509ar 62 6 are be VBP cord-278511-je1509ar 62 7 immunodeficient immunodeficient JJ cord-278511-je1509ar 62 8 [ [ -LRB- cord-278511-je1509ar 62 9 26 26 CD cord-278511-je1509ar 62 10 ] ] -RRB- cord-278511-je1509ar 62 11 or or CC cord-278511-je1509ar 62 12 that that WDT cord-278511-je1509ar 62 13 have have VBP cord-278511-je1509ar 62 14 been be VBN cord-278511-je1509ar 62 15 partially partially RB cord-278511-je1509ar 62 16 humanized humanize VBN cord-278511-je1509ar 62 17 [ [ -LRB- cord-278511-je1509ar 62 18 27 27 CD cord-278511-je1509ar 62 19 ] ] -RRB- cord-278511-je1509ar 62 20 has have VBZ cord-278511-je1509ar 62 21 enabled enable VBN cord-278511-je1509ar 62 22 development development NN cord-278511-je1509ar 62 23 of of IN cord-278511-je1509ar 62 24 murine murine JJ cord-278511-je1509ar 62 25 models model NNS cord-278511-je1509ar 62 26 for for IN cord-278511-je1509ar 62 27 some some DT cord-278511-je1509ar 62 28 viruses virus NNS cord-278511-je1509ar 62 29 . . . cord-278511-je1509ar 63 1 In in IN cord-278511-je1509ar 63 2 an an DT cord-278511-je1509ar 63 3 ideal ideal JJ cord-278511-je1509ar 63 4 world world NN cord-278511-je1509ar 63 5 , , , cord-278511-je1509ar 63 6 animal animal NN cord-278511-je1509ar 63 7 models model NNS cord-278511-je1509ar 63 8 for for IN cord-278511-je1509ar 63 9 all all DT cord-278511-je1509ar 63 10 eukaryotic eukaryotic JJ cord-278511-je1509ar 63 11 viruses virus NNS cord-278511-je1509ar 63 12 identified identify VBN cord-278511-je1509ar 63 13 in in IN cord-278511-je1509ar 63 14 virome virome NNP cord-278511-je1509ar 63 15 studies study NNS cord-278511-je1509ar 63 16 would would MD cord-278511-je1509ar 63 17 be be VB cord-278511-je1509ar 63 18 established establish VBN cord-278511-je1509ar 63 19 , , , cord-278511-je1509ar 63 20 enabling enable VBG cord-278511-je1509ar 63 21 the the DT cord-278511-je1509ar 63 22 roles role NNS cord-278511-je1509ar 63 23 of of IN cord-278511-je1509ar 63 24 any any DT cord-278511-je1509ar 63 25 single single JJ cord-278511-je1509ar 63 26 virus virus NN cord-278511-je1509ar 63 27 ( ( -LRB- cord-278511-je1509ar 63 28 or or CC cord-278511-je1509ar 63 29 cocktail cocktail NN cord-278511-je1509ar 63 30 of of IN cord-278511-je1509ar 63 31 viruses virus NNS cord-278511-je1509ar 63 32 ) ) -RRB- cord-278511-je1509ar 63 33 to to TO cord-278511-je1509ar 63 34 be be VB cord-278511-je1509ar 63 35 functionally functionally RB cord-278511-je1509ar 63 36 evaluated evaluate VBN cord-278511-je1509ar 63 37 . . . cord-278511-je1509ar 64 1 Likewise likewise RB cord-278511-je1509ar 64 2 , , , cord-278511-je1509ar 64 3 having have VBG cord-278511-je1509ar 64 4 an an DT cord-278511-je1509ar 64 5 extensive extensive JJ cord-278511-je1509ar 64 6 library library NN cord-278511-je1509ar 64 7 of of IN cord-278511-je1509ar 64 8 cultivated cultivate VBN cord-278511-je1509ar 64 9 phages phage NNS cord-278511-je1509ar 64 10 ( ( -LRB- cord-278511-je1509ar 64 11 see see VB cord-278511-je1509ar 64 12 above above RB cord-278511-je1509ar 64 13 ) ) -RRB- cord-278511-je1509ar 64 14 will will MD cord-278511-je1509ar 64 15 allow allow VB cord-278511-je1509ar 64 16 them -PRON- PRP cord-278511-je1509ar 64 17 to to TO cord-278511-je1509ar 64 18 be be VB cord-278511-je1509ar 64 19 combined combine VBN cord-278511-je1509ar 64 20 in in IN cord-278511-je1509ar 64 21 defined define VBN cord-278511-je1509ar 64 22 proportions proportion NNS cord-278511-je1509ar 64 23 along along IN cord-278511-je1509ar 64 24 with with IN cord-278511-je1509ar 64 25 eukaryotic eukaryotic JJ cord-278511-je1509ar 64 26 viruses virus NNS cord-278511-je1509ar 64 27 for for IN cord-278511-je1509ar 64 28 experimental experimental JJ cord-278511-je1509ar 64 29 studies study NNS cord-278511-je1509ar 64 30 . . . cord-278511-je1509ar 65 1 For for IN cord-278511-je1509ar 65 2 phages phage NNS cord-278511-je1509ar 65 3 , , , cord-278511-je1509ar 65 4 presuming presume VBG cord-278511-je1509ar 65 5 they -PRON- PRP cord-278511-je1509ar 65 6 act act VBP cord-278511-je1509ar 65 7 by by IN cord-278511-je1509ar 65 8 modulating modulate VBG cord-278511-je1509ar 65 9 the the DT cord-278511-je1509ar 65 10 bacterial bacterial JJ cord-278511-je1509ar 65 11 community community NN cord-278511-je1509ar 65 12 , , , cord-278511-je1509ar 65 13 the the DT cord-278511-je1509ar 65 14 animal animal NN cord-278511-je1509ar 65 15 model model NN cord-278511-je1509ar 65 16 must must MD cord-278511-je1509ar 65 17 harbor harbor VB cord-278511-je1509ar 65 18 the the DT cord-278511-je1509ar 65 19 relevant relevant JJ cord-278511-je1509ar 65 20 bacterial bacterial JJ cord-278511-je1509ar 65 21 host host NN cord-278511-je1509ar 65 22 species specie NNS cord-278511-je1509ar 65 23 , , , cord-278511-je1509ar 65 24 and and CC cord-278511-je1509ar 65 25 thus thus RB cord-278511-je1509ar 65 26 the the DT cord-278511-je1509ar 65 27 bacterial bacterial JJ cord-278511-je1509ar 65 28 microbiome microbiome NN cord-278511-je1509ar 65 29 may may MD cord-278511-je1509ar 65 30 need need VB cord-278511-je1509ar 65 31 to to TO cord-278511-je1509ar 65 32 be be VB cord-278511-je1509ar 65 33 manipulated manipulate VBN cord-278511-je1509ar 65 34 as as RB cord-278511-je1509ar 65 35 well well RB cord-278511-je1509ar 65 36 . . . cord-278511-je1509ar 66 1 Notably notably RB cord-278511-je1509ar 66 2 , , , cord-278511-je1509ar 66 3 some some DT cord-278511-je1509ar 66 4 recent recent JJ cord-278511-je1509ar 66 5 studies study NNS cord-278511-je1509ar 66 6 have have VBP cord-278511-je1509ar 66 7 suggested suggest VBN cord-278511-je1509ar 66 8 that that IN cord-278511-je1509ar 66 9 phages phage NNS cord-278511-je1509ar 66 10 may may MD cord-278511-je1509ar 66 11 also also RB cord-278511-je1509ar 66 12 interact interact VB cord-278511-je1509ar 66 13 directly directly RB cord-278511-je1509ar 66 14 with with IN cord-278511-je1509ar 66 15 eukaryotic eukaryotic JJ cord-278511-je1509ar 66 16 host host NN cord-278511-je1509ar 66 17 cells cell NNS cord-278511-je1509ar 66 18 [ [ -LRB- cord-278511-je1509ar 66 19 28 28 CD cord-278511-je1509ar 66 20 , , , cord-278511-je1509ar 66 21 29 29 CD cord-278511-je1509ar 66 22 ] ] -RRB- cord-278511-je1509ar 66 23 . . . cord-278511-je1509ar 67 1 Overall overall RB cord-278511-je1509ar 67 2 , , , cord-278511-je1509ar 67 3 significant significant JJ cord-278511-je1509ar 67 4 effort effort NN cord-278511-je1509ar 67 5 and and CC cord-278511-je1509ar 67 6 resources resource NNS cord-278511-je1509ar 67 7 must must MD cord-278511-je1509ar 67 8 be be VB cord-278511-je1509ar 67 9 expended expend VBN cord-278511-je1509ar 67 10 to to TO cord-278511-je1509ar 67 11 establish establish VB cord-278511-je1509ar 67 12 robust robust JJ cord-278511-je1509ar 67 13 animal animal NN cord-278511-je1509ar 67 14 - - HYPH cord-278511-je1509ar 67 15 infection infection NN cord-278511-je1509ar 67 16 models model NNS cord-278511-je1509ar 67 17 suitable suitable JJ cord-278511-je1509ar 67 18 to to TO cord-278511-je1509ar 67 19 define define VB cord-278511-je1509ar 67 20 the the DT cord-278511-je1509ar 67 21 role role NN cord-278511-je1509ar 67 22 of of IN cord-278511-je1509ar 67 23 the the DT cord-278511-je1509ar 67 24 virome virome NN cord-278511-je1509ar 67 25 . . . cord-278511-je1509ar 68 1 This this DT cord-278511-je1509ar 68 2 is be VBZ cord-278511-je1509ar 68 3 a a DT cord-278511-je1509ar 68 4 step step NN cord-278511-je1509ar 68 5 that that WDT cord-278511-je1509ar 68 6 is be VBZ cord-278511-je1509ar 68 7 absolutely absolutely RB cord-278511-je1509ar 68 8 necessary necessary JJ cord-278511-je1509ar 68 9 in in IN cord-278511-je1509ar 68 10 order order NN cord-278511-je1509ar 68 11 to to TO cord-278511-je1509ar 68 12 move move VB cord-278511-je1509ar 68 13 virome virome NNP cord-278511-je1509ar 68 14 studies study NNS cord-278511-je1509ar 68 15 beyond beyond IN cord-278511-je1509ar 68 16 the the DT cord-278511-je1509ar 68 17 realm realm NN cord-278511-je1509ar 68 18 of of IN cord-278511-je1509ar 68 19 mere mere NNP cord-278511-je1509ar 68 20 association association NN cord-278511-je1509ar 68 21 studies study NNS cord-278511-je1509ar 68 22 . . . cord-278511-je1509ar 69 1 A a DT cord-278511-je1509ar 69 2 barrier barrier NN cord-278511-je1509ar 69 3 to to TO cord-278511-je1509ar 69 4 progress progress VB cord-278511-je1509ar 69 5 in in IN cord-278511-je1509ar 69 6 the the DT cord-278511-je1509ar 69 7 virome virome JJ cord-278511-je1509ar 69 8 field field NN cord-278511-je1509ar 69 9 is be VBZ cord-278511-je1509ar 69 10 the the DT cord-278511-je1509ar 69 11 division division NN cord-278511-je1509ar 69 12 between between IN cord-278511-je1509ar 69 13 virologists virologist NNS cord-278511-je1509ar 69 14 who who WP cord-278511-je1509ar 69 15 study study VBP cord-278511-je1509ar 69 16 viruses virus NNS cord-278511-je1509ar 69 17 infecting infect VBG cord-278511-je1509ar 69 18 eukaryotes eukaryote NNS cord-278511-je1509ar 69 19 versus versus IN cord-278511-je1509ar 69 20 those those DT cord-278511-je1509ar 69 21 that that WDT cord-278511-je1509ar 69 22 infect infect VBP cord-278511-je1509ar 69 23 bacteria bacteria NNS cord-278511-je1509ar 69 24 . . . cord-278511-je1509ar 70 1 Very very RB cord-278511-je1509ar 70 2 few few JJ cord-278511-je1509ar 70 3 scientists scientist NNS cord-278511-je1509ar 70 4 today today NN cord-278511-je1509ar 70 5 have have VBP cord-278511-je1509ar 70 6 expertise expertise NN cord-278511-je1509ar 70 7 in in IN cord-278511-je1509ar 70 8 both both DT cord-278511-je1509ar 70 9 . . . cord-278511-je1509ar 71 1 This this DT cord-278511-je1509ar 71 2 balkanization balkanization NN cord-278511-je1509ar 71 3 of of IN cord-278511-je1509ar 71 4 virology virology NN cord-278511-je1509ar 71 5 leads lead VBZ cord-278511-je1509ar 71 6 to to IN cord-278511-je1509ar 71 7 challenges challenge NNS cord-278511-je1509ar 71 8 when when WRB cord-278511-je1509ar 71 9 an an DT cord-278511-je1509ar 71 10 eukaryotic eukaryotic JJ cord-278511-je1509ar 71 11 virologist virologist NN cord-278511-je1509ar 71 12 discovers discover VBZ cord-278511-je1509ar 71 13 in in IN cord-278511-je1509ar 71 14 a a DT cord-278511-je1509ar 71 15 virome virome JJ cord-278511-je1509ar 71 16 study study NN cord-278511-je1509ar 71 17 that that IN cord-278511-je1509ar 71 18 the the DT cord-278511-je1509ar 71 19 strongest strong JJS cord-278511-je1509ar 71 20 disease disease NN cord-278511-je1509ar 71 21 association association NNP cord-278511-je1509ar 71 22 is be VBZ cord-278511-je1509ar 71 23 with with IN cord-278511-je1509ar 71 24 a a DT cord-278511-je1509ar 71 25 phage phage NN cord-278511-je1509ar 71 26 ( ( -LRB- cord-278511-je1509ar 71 27 or or CC cord-278511-je1509ar 71 28 vice vice NN cord-278511-je1509ar 71 29 versa versa RB cord-278511-je1509ar 71 30 ) ) -RRB- cord-278511-je1509ar 71 31 . . . cord-278511-je1509ar 72 1 Lack lack NN cord-278511-je1509ar 72 2 of of IN cord-278511-je1509ar 72 3 familiarity familiarity NN cord-278511-je1509ar 72 4 with with IN cord-278511-je1509ar 72 5 the the DT cord-278511-je1509ar 72 6 field field NN cord-278511-je1509ar 72 7 and and CC cord-278511-je1509ar 72 8 relevant relevant JJ cord-278511-je1509ar 72 9 experimental experimental JJ cord-278511-je1509ar 72 10 approaches approach NNS cord-278511-je1509ar 72 11 often often RB cord-278511-je1509ar 72 12 limits limit VBZ cord-278511-je1509ar 72 13 further further JJ cord-278511-je1509ar 72 14 investigation investigation NN cord-278511-je1509ar 72 15 . . . cord-278511-je1509ar 73 1 These these DT cord-278511-je1509ar 73 2 communities community NNS cord-278511-je1509ar 73 3 have have VBP cord-278511-je1509ar 73 4 been be VBN cord-278511-je1509ar 73 5 largely largely RB cord-278511-je1509ar 73 6 segregated segregate VBN cord-278511-je1509ar 73 7 , , , cord-278511-je1509ar 73 8 often often RB cord-278511-je1509ar 73 9 holding hold VBG cord-278511-je1509ar 73 10 separate separate JJ cord-278511-je1509ar 73 11 conferences conference NNS cord-278511-je1509ar 73 12 and and CC cord-278511-je1509ar 73 13 distinct distinct JJ cord-278511-je1509ar 73 14 grant grant NN cord-278511-je1509ar 73 15 - - HYPH cord-278511-je1509ar 73 16 review review NN cord-278511-je1509ar 73 17 panels panel NNS cord-278511-je1509ar 73 18 . . . cord-278511-je1509ar 74 1 To to TO cord-278511-je1509ar 74 2 illustrate illustrate VB cord-278511-je1509ar 74 3 this this DT cord-278511-je1509ar 74 4 point point NN cord-278511-je1509ar 74 5 , , , cord-278511-je1509ar 74 6 the the DT cord-278511-je1509ar 74 7 United United NNP cord-278511-je1509ar 74 8 States States NNP cord-278511-je1509ar 74 9 National National NNP cord-278511-je1509ar 74 10 Institutes Institutes NNPS cord-278511-je1509ar 74 11 of of IN cord-278511-je1509ar 74 12 Health Health NNP cord-278511-je1509ar 74 13 ( ( -LRB- cord-278511-je1509ar 74 14 NIH NIH NNP cord-278511-je1509ar 74 15 ) ) -RRB- cord-278511-je1509ar 74 16 virology virology NN cord-278511-je1509ar 74 17 study study NN cord-278511-je1509ar 74 18 sections section NNS cord-278511-je1509ar 74 19 address address VBP cord-278511-je1509ar 74 20 only only RB cord-278511-je1509ar 74 21 " " `` cord-278511-je1509ar 74 22 non non JJ cord-278511-je1509ar 74 23 - - JJ cord-278511-je1509ar 74 24 bacteriophage bacteriophage JJ cord-278511-je1509ar 74 25 viral viral JJ cord-278511-je1509ar 74 26 genetics genetic NNS cord-278511-je1509ar 74 27 , , , cord-278511-je1509ar 74 28 infection infection NN cord-278511-je1509ar 74 29 and and CC cord-278511-je1509ar 74 30 replication replication NN cord-278511-je1509ar 74 31 , , , cord-278511-je1509ar 74 32 cellular cellular JJ cord-278511-je1509ar 74 33 and and CC cord-278511-je1509ar 74 34 host host NN cord-278511-je1509ar 74 35 responses response NNS cord-278511-je1509ar 74 36 to to IN cord-278511-je1509ar 74 37 viral viral JJ cord-278511-je1509ar 74 38 infections infection NNS cord-278511-je1509ar 74 39 , , , cord-278511-je1509ar 74 40 and and CC cord-278511-je1509ar 74 41 mechanisms mechanism NNS cord-278511-je1509ar 74 42 of of IN cord-278511-je1509ar 74 43 viral viral JJ cord-278511-je1509ar 74 44 disease disease NN cord-278511-je1509ar 74 45 pathogenesis pathogenesis NN cord-278511-je1509ar 74 46 . . . cord-278511-je1509ar 74 47 " " '' cord-278511-je1509ar 75 1 Thus thus RB cord-278511-je1509ar 75 2 , , , cord-278511-je1509ar 75 3 there there EX cord-278511-je1509ar 75 4 is be VBZ cord-278511-je1509ar 75 5 a a DT cord-278511-je1509ar 75 6 great great JJ cord-278511-je1509ar 75 7 need need NN cord-278511-je1509ar 75 8 to to TO cord-278511-je1509ar 75 9 bring bring VB cord-278511-je1509ar 75 10 these these DT cord-278511-je1509ar 75 11 disparate disparate JJ cord-278511-je1509ar 75 12 communities community NNS cord-278511-je1509ar 75 13 together together RB cord-278511-je1509ar 75 14 in in IN cord-278511-je1509ar 75 15 order order NN cord-278511-je1509ar 75 16 to to TO cord-278511-je1509ar 75 17 collectively collectively RB cord-278511-je1509ar 75 18 attack attack VB cord-278511-je1509ar 75 19 questions question NNS cord-278511-je1509ar 75 20 associated associate VBN cord-278511-je1509ar 75 21 with with IN cord-278511-je1509ar 75 22 the the DT cord-278511-je1509ar 75 23 virome virome NN cord-278511-je1509ar 75 24 , , , cord-278511-je1509ar 75 25 especially especially RB cord-278511-je1509ar 75 26 as as IN cord-278511-je1509ar 75 27 more more RBR cord-278511-je1509ar 75 28 complex complex JJ cord-278511-je1509ar 75 29 trans trans JJ cord-278511-je1509ar 75 30 - - JJ cord-278511-je1509ar 75 31 kingdom kingdom JJ cord-278511-je1509ar 75 32 interactions interaction NNS cord-278511-je1509ar 75 33 are be VBP cord-278511-je1509ar 75 34 identified identify VBN cord-278511-je1509ar 75 35 linking link VBG cord-278511-je1509ar 75 36 phages phage NNS cord-278511-je1509ar 75 37 , , , cord-278511-je1509ar 75 38 bacteria bacteria NNS cord-278511-je1509ar 75 39 , , , cord-278511-je1509ar 75 40 eukaryotic eukaryotic JJ cord-278511-je1509ar 75 41 viruses virus NNS cord-278511-je1509ar 75 42 , , , cord-278511-je1509ar 75 43 and and CC cord-278511-je1509ar 75 44 eukaryotic eukaryotic JJ cord-278511-je1509ar 75 45 cells cell NNS cord-278511-je1509ar 75 46 . . . cord-278511-je1509ar 76 1 In in IN cord-278511-je1509ar 76 2 conclusion conclusion NN cord-278511-je1509ar 76 3 , , , cord-278511-je1509ar 76 4 the the DT cord-278511-je1509ar 76 5 coming come VBG cord-278511-je1509ar 76 6 years year NNS cord-278511-je1509ar 76 7 will will MD cord-278511-je1509ar 76 8 undoubtedly undoubtedly RB cord-278511-je1509ar 76 9 be be VB cord-278511-je1509ar 76 10 witness witness NN cord-278511-je1509ar 76 11 to to IN cord-278511-je1509ar 76 12 many many JJ cord-278511-je1509ar 76 13 more more JJR cord-278511-je1509ar 76 14 studies study NNS cord-278511-je1509ar 76 15 demonstrating demonstrate VBG cord-278511-je1509ar 76 16 associations association NNS cord-278511-je1509ar 76 17 of of IN cord-278511-je1509ar 76 18 the the DT cord-278511-je1509ar 76 19 virome virome NN cord-278511-je1509ar 76 20 with with IN cord-278511-je1509ar 76 21 various various JJ cord-278511-je1509ar 76 22 diseases disease NNS cord-278511-je1509ar 76 23 . . . cord-278511-je1509ar 77 1 Hopefully hopefully RB cord-278511-je1509ar 77 2 , , , cord-278511-je1509ar 77 3 there there EX cord-278511-je1509ar 77 4 will will MD cord-278511-je1509ar 77 5 be be VB cord-278511-je1509ar 77 6 commensurate commensurate JJ cord-278511-je1509ar 77 7 development development NN cord-278511-je1509ar 77 8 of of IN cord-278511-je1509ar 77 9 new new JJ cord-278511-je1509ar 77 10 computational computational JJ cord-278511-je1509ar 77 11 approaches approach NNS cord-278511-je1509ar 77 12 that that WDT cord-278511-je1509ar 77 13 significantly significantly RB cord-278511-je1509ar 77 14 decrease decrease VBP cord-278511-je1509ar 77 15 the the DT cord-278511-je1509ar 77 16 fraction fraction NN cord-278511-je1509ar 77 17 of of IN cord-278511-je1509ar 77 18 viral viral JJ cord-278511-je1509ar 77 19 dark dark JJ cord-278511-je1509ar 77 20 matter matter NN cord-278511-je1509ar 77 21 and and CC cord-278511-je1509ar 77 22 an an DT cord-278511-je1509ar 77 23 increase increase NN cord-278511-je1509ar 77 24 in in IN cord-278511-je1509ar 77 25 the the DT cord-278511-je1509ar 77 26 fraction fraction NN cord-278511-je1509ar 77 27 of of IN cord-278511-je1509ar 77 28 studies study NNS cord-278511-je1509ar 77 29 that that WDT cord-278511-je1509ar 77 30 holistically holistically RB cord-278511-je1509ar 77 31 evaluate evaluate VBP cord-278511-je1509ar 77 32 the the DT cord-278511-je1509ar 77 33 virome virome NN cord-278511-je1509ar 77 34 . . . cord-278511-je1509ar 78 1 With with IN cord-278511-je1509ar 78 2 new new JJ cord-278511-je1509ar 78 3 cell cell NN cord-278511-je1509ar 78 4 - - HYPH cord-278511-je1509ar 78 5 culture culture NN cord-278511-je1509ar 78 6 systems system NNS cord-278511-je1509ar 78 7 and and CC cord-278511-je1509ar 78 8 animal animal NN cord-278511-je1509ar 78 9 models model NNS cord-278511-je1509ar 78 10 for for IN cord-278511-je1509ar 78 11 novel novel JJ cord-278511-je1509ar 78 12 viruses virus NNS cord-278511-je1509ar 78 13 , , , cord-278511-je1509ar 78 14 there there EX cord-278511-je1509ar 78 15 will will MD cord-278511-je1509ar 78 16 ideally ideally RB cord-278511-je1509ar 78 17 be be VB cord-278511-je1509ar 78 18 studies study NNS cord-278511-je1509ar 78 19 that that WDT cord-278511-je1509ar 78 20 attribute attribute VBP cord-278511-je1509ar 78 21 causal causal JJ cord-278511-je1509ar 78 22 roles role NNS cord-278511-je1509ar 78 23 for for IN cord-278511-je1509ar 78 24 some some DT cord-278511-je1509ar 78 25 of of IN cord-278511-je1509ar 78 26 the the DT cord-278511-je1509ar 78 27 associations association NNS cord-278511-je1509ar 78 28 . . . cord-278511-je1509ar 79 1 Finally finally RB cord-278511-je1509ar 79 2 , , , cord-278511-je1509ar 79 3 it -PRON- PRP cord-278511-je1509ar 79 4 may may MD cord-278511-je1509ar 79 5 be be VB cord-278511-je1509ar 79 6 that that IN cord-278511-je1509ar 79 7 virome virome NNP cord-278511-je1509ar 79 8 studies study NNS cord-278511-je1509ar 79 9 will will MD cord-278511-je1509ar 79 10 serve serve VB cord-278511-je1509ar 79 11 as as IN cord-278511-je1509ar 79 12 a a DT cord-278511-je1509ar 79 13 catalyst catalyst NN cord-278511-je1509ar 79 14 to to TO cord-278511-je1509ar 79 15 help help VB cord-278511-je1509ar 79 16 integrate integrate VB cord-278511-je1509ar 79 17 the the DT cord-278511-je1509ar 79 18 eukaryotic eukaryotic JJ cord-278511-je1509ar 79 19 viral viral JJ cord-278511-je1509ar 79 20 and and CC cord-278511-je1509ar 79 21 phage phage NN cord-278511-je1509ar 79 22 communities community NNS cord-278511-je1509ar 79 23 . . . cord-278511-je1509ar 80 1 Pathogenic pathogenic JJ cord-278511-je1509ar 80 2 simian simian JJ cord-278511-je1509ar 80 3 immunodeficiency immunodeficiency NN cord-278511-je1509ar 80 4 virus virus NN cord-278511-je1509ar 80 5 infection infection NN cord-278511-je1509ar 80 6 is be VBZ cord-278511-je1509ar 80 7 associated associate VBN cord-278511-je1509ar 80 8 with with IN cord-278511-je1509ar 80 9 expansion expansion NN cord-278511-je1509ar 80 10 of of IN cord-278511-je1509ar 80 11 the the DT cord-278511-je1509ar 80 12 enteric enteric JJ cord-278511-je1509ar 80 13 virome virome NN cord-278511-je1509ar 80 14 Altered alter VBD cord-278511-je1509ar 80 15 Virome Virome NNP cord-278511-je1509ar 80 16 and and CC cord-278511-je1509ar 80 17 Bacterial bacterial JJ cord-278511-je1509ar 80 18 Microbiome Microbiome NNP cord-278511-je1509ar 80 19 in in IN cord-278511-je1509ar 80 20 Human Human NNP cord-278511-je1509ar 80 21 Immunodeficiency Immunodeficiency NNP cord-278511-je1509ar 80 22 Virus Virus NNP cord-278511-je1509ar 80 23 - - HYPH cord-278511-je1509ar 80 24 Associated Associated NNP cord-278511-je1509ar 80 25 Acquired Acquired NNP cord-278511-je1509ar 80 26 Immunodeficiency Immunodeficiency NNP cord-278511-je1509ar 80 27 Syndrome Syndrome NNP cord-278511-je1509ar 80 28 Disease Disease NNP cord-278511-je1509ar 80 29 - - HYPH cord-278511-je1509ar 80 30 specific specific JJ cord-278511-je1509ar 80 31 alterations alteration NNS cord-278511-je1509ar 80 32 in in IN cord-278511-je1509ar 80 33 the the DT cord-278511-je1509ar 80 34 enteric enteric JJ cord-278511-je1509ar 80 35 virome virome NN cord-278511-je1509ar 80 36 in in IN cord-278511-je1509ar 80 37 inflammatory inflammatory JJ cord-278511-je1509ar 80 38 bowel bowel NN cord-278511-je1509ar 80 39 disease disease NN cord-278511-je1509ar 80 40 Gut gut NN cord-278511-je1509ar 80 41 DNA dna NN cord-278511-je1509ar 80 42 viromes virome NNS cord-278511-je1509ar 80 43 of of IN cord-278511-je1509ar 80 44 Malawian malawian JJ cord-278511-je1509ar 80 45 twins twin NNS cord-278511-je1509ar 80 46 discordant discordant JJ cord-278511-je1509ar 80 47 for for IN cord-278511-je1509ar 80 48 severe severe JJ cord-278511-je1509ar 80 49 acute acute JJ cord-278511-je1509ar 80 50 malnutrition malnutrition NN cord-278511-je1509ar 81 1 The the DT cord-278511-je1509ar 81 2 eukaryotic eukaryotic JJ cord-278511-je1509ar 81 3 gut gut NN cord-278511-je1509ar 81 4 virome virome NN cord-278511-je1509ar 81 5 in in IN cord-278511-je1509ar 81 6 hematopoietic hematopoietic JJ cord-278511-je1509ar 81 7 stem stem NN cord-278511-je1509ar 81 8 cell cell NN cord-278511-je1509ar 81 9 transplantation transplantation NN cord-278511-je1509ar 81 10 : : : cord-278511-je1509ar 81 11 new new JJ cord-278511-je1509ar 81 12 clues clue NNS cord-278511-je1509ar 81 13 in in IN cord-278511-je1509ar 81 14 enteric enteric JJ cord-278511-je1509ar 81 15 graft graft NN cord-278511-je1509ar 81 16 - - HYPH cord-278511-je1509ar 81 17 versus versus IN cord-278511-je1509ar 81 18 - - HYPH cord-278511-je1509ar 81 19 host host NN cord-278511-je1509ar 81 20 disease disease NN cord-278511-je1509ar 81 21 Distinct Distinct NNP cord-278511-je1509ar 81 22 Gut gut NN cord-278511-je1509ar 81 23 Virome Virome NNP cord-278511-je1509ar 81 24 Profile Profile NNP cord-278511-je1509ar 81 25 of of IN cord-278511-je1509ar 81 26 Pregnant pregnant JJ cord-278511-je1509ar 81 27 Women Women NNP cord-278511-je1509ar 81 28 With with IN cord-278511-je1509ar 81 29 Type type NN cord-278511-je1509ar 81 30 1 1 CD cord-278511-je1509ar 81 31 Diabetes diabetes NN cord-278511-je1509ar 81 32 in in IN cord-278511-je1509ar 81 33 the the DT cord-278511-je1509ar 81 34 ENDIA ENDIA NNP cord-278511-je1509ar 81 35 Study Study NNP cord-278511-je1509ar 81 36 . . . cord-278511-je1509ar 82 1 Open open VB cord-278511-je1509ar 82 2 forum forum NN cord-278511-je1509ar 82 3 infectious infectious JJ cord-278511-je1509ar 82 4 diseases disease NNS cord-278511-je1509ar 83 1 Intestinal intestinal JJ cord-278511-je1509ar 83 2 virome virome NN cord-278511-je1509ar 83 3 changes change NNS cord-278511-je1509ar 83 4 precede precede VBP cord-278511-je1509ar 83 5 autoimmunity autoimmunity NN cord-278511-je1509ar 83 6 in in IN cord-278511-je1509ar 83 7 type type NN cord-278511-je1509ar 84 1 I -PRON- PRP cord-278511-je1509ar 84 2 diabetes diabetes NN cord-278511-je1509ar 84 3 - - HYPH cord-278511-je1509ar 84 4 susceptible susceptible JJ cord-278511-je1509ar 84 5 children child NNS cord-278511-je1509ar 84 6 Origins origin NNS cord-278511-je1509ar 84 7 and and CC cord-278511-je1509ar 84 8 challenges challenge NNS cord-278511-je1509ar 84 9 of of IN cord-278511-je1509ar 84 10 viral viral JJ cord-278511-je1509ar 84 11 dark dark JJ cord-278511-je1509ar 84 12 matter matter NN cord-278511-je1509ar 84 13 A a DT cord-278511-je1509ar 84 14 highly highly RB cord-278511-je1509ar 84 15 abundant abundant JJ cord-278511-je1509ar 84 16 bacteriophage bacteriophage NN cord-278511-je1509ar 84 17 discovered discover VBN cord-278511-je1509ar 84 18 in in IN cord-278511-je1509ar 84 19 the the DT cord-278511-je1509ar 84 20 unknown unknown JJ cord-278511-je1509ar 84 21 sequences sequence NNS cord-278511-je1509ar 84 22 of of IN cord-278511-je1509ar 84 23 human human JJ cord-278511-je1509ar 84 24 faecal faecal JJ cord-278511-je1509ar 84 25 metagenomes metagenomes NNP cord-278511-je1509ar 84 26 Profile Profile NNP cord-278511-je1509ar 84 27 hidden hide VBN cord-278511-je1509ar 84 28 Markov Markov NNP cord-278511-je1509ar 84 29 models model NNS cord-278511-je1509ar 84 30 for for IN cord-278511-je1509ar 84 31 the the DT cord-278511-je1509ar 84 32 detection detection NN cord-278511-je1509ar 84 33 of of IN cord-278511-je1509ar 84 34 viruses virus NNS cord-278511-je1509ar 84 35 within within IN cord-278511-je1509ar 84 36 metagenomic metagenomic NNP cord-278511-je1509ar 84 37 sequence sequence NN cord-278511-je1509ar 84 38 data data NNP cord-278511-je1509ar 84 39 VirFinder VirFinder NNP cord-278511-je1509ar 84 40 : : : cord-278511-je1509ar 84 41 a a DT cord-278511-je1509ar 84 42 novel novel JJ cord-278511-je1509ar 84 43 k k NNP cord-278511-je1509ar 84 44 - - HYPH cord-278511-je1509ar 84 45 mer mer NNP cord-278511-je1509ar 84 46 based base VBN cord-278511-je1509ar 84 47 tool tool NN cord-278511-je1509ar 84 48 for for IN cord-278511-je1509ar 84 49 identifying identify VBG cord-278511-je1509ar 84 50 viral viral JJ cord-278511-je1509ar 84 51 sequences sequence NNS cord-278511-je1509ar 84 52 from from IN cord-278511-je1509ar 84 53 assembled assemble VBN cord-278511-je1509ar 84 54 metagenomic metagenomic NNP cord-278511-je1509ar 84 55 data datum NNS cord-278511-je1509ar 84 56 Artificial artificial JJ cord-278511-je1509ar 84 57 neural neural JJ cord-278511-je1509ar 84 58 networks network NNS cord-278511-je1509ar 84 59 trained train VBN cord-278511-je1509ar 84 60 to to TO cord-278511-je1509ar 84 61 detect detect VB cord-278511-je1509ar 84 62 viral viral JJ cord-278511-je1509ar 84 63 and and CC cord-278511-je1509ar 84 64 phage phage NN cord-278511-je1509ar 84 65 structural structural JJ cord-278511-je1509ar 84 66 proteins protein NNS cord-278511-je1509ar 84 67 Hyperexpansion Hyperexpansion NNP cord-278511-je1509ar 84 68 of of IN cord-278511-je1509ar 84 69 RNA RNA NNP cord-278511-je1509ar 84 70 Bacteriophage Bacteriophage NNP cord-278511-je1509ar 84 71 Diversity Diversity NNP cord-278511-je1509ar 84 72 Cultivation Cultivation NNP cord-278511-je1509ar 84 73 and and CC cord-278511-je1509ar 84 74 serological serological JJ cord-278511-je1509ar 84 75 characterization characterization NN cord-278511-je1509ar 84 76 of of IN cord-278511-je1509ar 84 77 a a DT cord-278511-je1509ar 84 78 human human JJ cord-278511-je1509ar 84 79 Theiler's Theiler's NNP cord-278511-je1509ar 84 80 - - HYPH cord-278511-je1509ar 84 81 like like JJ cord-278511-je1509ar 84 82 cardiovirus cardiovirus NNP cord-278511-je1509ar 84 83 associated associate VBN cord-278511-je1509ar 84 84 with with IN cord-278511-je1509ar 84 85 diarrheal diarrheal JJ cord-278511-je1509ar 84 86 disease disease NN cord-278511-je1509ar 84 87 Propagation Propagation NNP cord-278511-je1509ar 84 88 of of IN cord-278511-je1509ar 84 89 astrovirus astrovirus NNP cord-278511-je1509ar 84 90 VA1 VA1 NNP cord-278511-je1509ar 84 91 , , , cord-278511-je1509ar 84 92 a a DT cord-278511-je1509ar 84 93 neurotropic neurotropic NNP cord-278511-je1509ar 84 94 human human NN cord-278511-je1509ar 84 95 astrovirus astrovirus NNP cord-278511-je1509ar 84 96 , , , cord-278511-je1509ar 84 97 in in IN cord-278511-je1509ar 84 98 cell cell NN cord-278511-je1509ar 84 99 culture culture NN cord-278511-je1509ar 84 100 Marine marine NN cord-278511-je1509ar 84 101 DNA DNA NNP cord-278511-je1509ar 84 102 Viral Viral NNP cord-278511-je1509ar 84 103 Macro Macro NNP cord-278511-je1509ar 84 104 - - : cord-278511-je1509ar 84 105 and and CC cord-278511-je1509ar 84 106 Microdiversity Microdiversity NNP cord-278511-je1509ar 84 107 from from IN cord-278511-je1509ar 84 108 Pole Pole NNP cord-278511-je1509ar 84 109 to to IN cord-278511-je1509ar 84 110 Pole Pole NNP cord-278511-je1509ar 84 111 Viral viral JJ cord-278511-je1509ar 84 112 dark dark JJ cord-278511-je1509ar 84 113 matter matter NN cord-278511-je1509ar 84 114 and and CC cord-278511-je1509ar 84 115 virus virus NN cord-278511-je1509ar 84 116 - - HYPH cord-278511-je1509ar 84 117 host host NN cord-278511-je1509ar 84 118 interactions interaction NNS cord-278511-je1509ar 84 119 resolved resolve VBN cord-278511-je1509ar 84 120 from from IN cord-278511-je1509ar 84 121 publicly publicly RB cord-278511-je1509ar 84 122 available available JJ cord-278511-je1509ar 84 123 microbial microbial JJ cord-278511-je1509ar 84 124 genomes genome NNS cord-278511-je1509ar 85 1 PhiCrAss001 PhiCrAss001 NNP cord-278511-je1509ar 85 2 represents represent VBZ cord-278511-je1509ar 85 3 the the DT cord-278511-je1509ar 85 4 most most RBS cord-278511-je1509ar 85 5 abundant abundant JJ cord-278511-je1509ar 85 6 bacteriophage bacteriophage NN cord-278511-je1509ar 85 7 family family NN cord-278511-je1509ar 85 8 in in IN cord-278511-je1509ar 85 9 the the DT cord-278511-je1509ar 85 10 human human JJ cord-278511-je1509ar 85 11 gut gut NN cord-278511-je1509ar 85 12 and and CC cord-278511-je1509ar 85 13 infects infect VBZ cord-278511-je1509ar 85 14 Bacteroides Bacteroides NNP cord-278511-je1509ar 85 15 intestinalis intestinalis NNP cord-278511-je1509ar 85 16 Human Human NNP cord-278511-je1509ar 85 17 bocavirus bocavirus NN cord-278511-je1509ar 85 18 can can MD cord-278511-je1509ar 85 19 be be VB cord-278511-je1509ar 85 20 cultured culture VBN cord-278511-je1509ar 85 21 in in IN cord-278511-je1509ar 85 22 differentiated differentiated JJ cord-278511-je1509ar 85 23 human human JJ cord-278511-je1509ar 85 24 airway airway NN cord-278511-je1509ar 85 25 epithelial epithelial JJ cord-278511-je1509ar 85 26 cells cell NNS cord-278511-je1509ar 85 27 Culturing culture VBG cord-278511-je1509ar 85 28 the the DT cord-278511-je1509ar 85 29 Unculturable Unculturable NNP cord-278511-je1509ar 85 30 : : : cord-278511-je1509ar 86 1 Human human JJ cord-278511-je1509ar 86 2 Coronavirus Coronavirus NNP cord-278511-je1509ar 86 3 HKU1 HKU1 NNP cord-278511-je1509ar 86 4 Infects infect VBZ cord-278511-je1509ar 86 5 , , , cord-278511-je1509ar 86 6 Replicates Replicates NNPS cord-278511-je1509ar 86 7 , , , cord-278511-je1509ar 86 8 and and CC cord-278511-je1509ar 86 9 Produces produce VBZ cord-278511-je1509ar 86 10 Progeny Progeny NNP cord-278511-je1509ar 86 11 Virions Virions NNP cord-278511-je1509ar 86 12 in in IN cord-278511-je1509ar 86 13 Human Human NNP cord-278511-je1509ar 86 14 Ciliated Ciliated NNP cord-278511-je1509ar 86 15 Airway Airway NNP cord-278511-je1509ar 86 16 Epithelial epithelial JJ cord-278511-je1509ar 86 17 Cell cell NN cord-278511-je1509ar 86 18 Cultures culture NNS cord-278511-je1509ar 86 19 Replication Replication NNP cord-278511-je1509ar 86 20 of of IN cord-278511-je1509ar 86 21 human human JJ cord-278511-je1509ar 86 22 noroviruses noroviruse NNS cord-278511-je1509ar 86 23 in in IN cord-278511-je1509ar 86 24 stem stem NN cord-278511-je1509ar 86 25 cell cell NN cord-278511-je1509ar 86 26 - - HYPH cord-278511-je1509ar 86 27 derived derive VBN cord-278511-je1509ar 86 28 human human JJ cord-278511-je1509ar 86 29 enteroids enteroid NNS cord-278511-je1509ar 86 30 Enteric enteric JJ cord-278511-je1509ar 86 31 bacteria bacteria NNS cord-278511-je1509ar 86 32 promote promote VBP cord-278511-je1509ar 86 33 human human JJ cord-278511-je1509ar 86 34 and and CC cord-278511-je1509ar 86 35 mouse mouse NN cord-278511-je1509ar 86 36 norovirus norovirus NN cord-278511-je1509ar 86 37 infection infection NN cord-278511-je1509ar 86 38 of of IN cord-278511-je1509ar 86 39 B b NN cord-278511-je1509ar 86 40 cells cell NNS cord-278511-je1509ar 86 41 Cultivation cultivation NN cord-278511-je1509ar 86 42 of of IN cord-278511-je1509ar 86 43 stable stable JJ cord-278511-je1509ar 86 44 , , , cord-278511-je1509ar 86 45 reproducible reproducible JJ cord-278511-je1509ar 86 46 microbial microbial JJ cord-278511-je1509ar 86 47 communities community NNS cord-278511-je1509ar 86 48 from from IN cord-278511-je1509ar 86 49 different different JJ cord-278511-je1509ar 86 50 fecal fecal JJ cord-278511-je1509ar 86 51 donors donor NNS cord-278511-je1509ar 86 52 using use VBG cord-278511-je1509ar 86 53 minibioreactor minibioreactor NNP cord-278511-je1509ar 86 54 arrays array NNS cord-278511-je1509ar 86 55 ( ( -LRB- cord-278511-je1509ar 86 56 MBRAs mbra NNS cord-278511-je1509ar 86 57 ) ) -RRB- cord-278511-je1509ar 87 1 Chemostat Chemostat NNP cord-278511-je1509ar 87 2 culture culture NN cord-278511-je1509ar 87 3 systems system NNS cord-278511-je1509ar 87 4 support support VBP cord-278511-je1509ar 87 5 diverse diverse JJ cord-278511-je1509ar 87 6 bacteriophage bacteriophage NN cord-278511-je1509ar 87 7 communities community NNS cord-278511-je1509ar 87 8 from from IN cord-278511-je1509ar 87 9 human human JJ cord-278511-je1509ar 87 10 feces fece NNS cord-278511-je1509ar 88 1 A a DT cord-278511-je1509ar 88 2 new new JJ cord-278511-je1509ar 88 3 antibiotic antibiotic NN cord-278511-je1509ar 88 4 kills kill NNS cord-278511-je1509ar 88 5 pathogens pathogen NNS cord-278511-je1509ar 88 6 without without IN cord-278511-je1509ar 88 7 detectable detectable JJ cord-278511-je1509ar 88 8 resistance resistance NN cord-278511-je1509ar 89 1 A a DT cord-278511-je1509ar 89 2 Mouse Mouse NNP cord-278511-je1509ar 89 3 Model Model NNP cord-278511-je1509ar 89 4 of of IN cord-278511-je1509ar 89 5 Zika Zika NNP cord-278511-je1509ar 89 6 Virus Virus NNP cord-278511-je1509ar 89 7 Pathogenesis Pathogenesis NNP cord-278511-je1509ar 89 8 Precision Precision NNP cord-278511-je1509ar 89 9 mouse mouse NN cord-278511-je1509ar 89 10 models model NNS cord-278511-je1509ar 89 11 with with IN cord-278511-je1509ar 89 12 expanded expand VBN cord-278511-je1509ar 89 13 tropism tropism NN cord-278511-je1509ar 89 14 for for IN cord-278511-je1509ar 89 15 human human JJ cord-278511-je1509ar 89 16 pathogens pathogen NNS cord-278511-je1509ar 89 17 Expansion Expansion NNP cord-278511-je1509ar 89 18 of of IN cord-278511-je1509ar 89 19 Bacteriophages Bacteriophages NNPS cord-278511-je1509ar 89 20 Is be VBZ cord-278511-je1509ar 89 21 Linked link VBN cord-278511-je1509ar 89 22 to to IN cord-278511-je1509ar 89 23 Aggravated aggravated JJ cord-278511-je1509ar 89 24 Intestinal intestinal JJ cord-278511-je1509ar 89 25 Inflammation inflammation NN cord-278511-je1509ar 89 26 and and CC cord-278511-je1509ar 89 27 Colitis Colitis NNP cord-278511-je1509ar 89 28 Bacteriophage Bacteriophage NNP cord-278511-je1509ar 89 29 trigger trigger VB cord-278511-je1509ar 89 30 antiviral antiviral JJ cord-278511-je1509ar 89 31 immunity immunity NN cord-278511-je1509ar 89 32 and and CC cord-278511-je1509ar 89 33 prevent prevent VB cord-278511-je1509ar 89 34 clearance clearance NN cord-278511-je1509ar 89 35 of of IN cord-278511-je1509ar 89 36 bacterial bacterial JJ cord-278511-je1509ar 89 37 infection infection NN