id sid tid token lemma pos cord-334315-ymkrgj0h 1 1 key key NN cord-334315-ymkrgj0h 1 2 : : : cord-334315-ymkrgj0h 2 1 cord-334315-ymkrgj0h cord-334315-ymkrgj0h NNS cord-334315-ymkrgj0h 2 2 authors author NNS cord-334315-ymkrgj0h 2 3 : : : cord-334315-ymkrgj0h 2 4 Moon Moon NNP cord-334315-ymkrgj0h 2 5 , , , cord-334315-ymkrgj0h 2 6 Stephanie Stephanie NNP cord-334315-ymkrgj0h 2 7 L. L. NNP cord-334315-ymkrgj0h 2 8 ; ; : cord-334315-ymkrgj0h 2 9 Wilusz Wilusz NNP cord-334315-ymkrgj0h 2 10 , , , cord-334315-ymkrgj0h 2 11 Jeffrey Jeffrey NNP cord-334315-ymkrgj0h 2 12 title title NN cord-334315-ymkrgj0h 2 13 : : : cord-334315-ymkrgj0h 2 14 Cytoplasmic Cytoplasmic NNP cord-334315-ymkrgj0h 2 15 Viruses virus NNS cord-334315-ymkrgj0h 2 16 : : : cord-334315-ymkrgj0h 3 1 Rage rage NN cord-334315-ymkrgj0h 3 2 against against IN cord-334315-ymkrgj0h 3 3 the the DT cord-334315-ymkrgj0h 3 4 ( ( -LRB- cord-334315-ymkrgj0h 3 5 Cellular Cellular NNP cord-334315-ymkrgj0h 3 6 RNA RNA NNP cord-334315-ymkrgj0h 3 7 Decay decay NN cord-334315-ymkrgj0h 3 8 ) ) -RRB- cord-334315-ymkrgj0h 4 1 Machine machine NN cord-334315-ymkrgj0h 4 2 date date NN cord-334315-ymkrgj0h 4 3 : : : cord-334315-ymkrgj0h 4 4 2013 2013 CD cord-334315-ymkrgj0h 4 5 - - SYM cord-334315-ymkrgj0h 4 6 12 12 CD cord-334315-ymkrgj0h 4 7 - - HYPH cord-334315-ymkrgj0h 4 8 05 05 CD cord-334315-ymkrgj0h 4 9 journal journal NN cord-334315-ymkrgj0h 4 10 : : : cord-334315-ymkrgj0h 5 1 PLoS PLoS NNP cord-334315-ymkrgj0h 5 2 Pathog Pathog NNP cord-334315-ymkrgj0h 5 3 DOI DOI NNP cord-334315-ymkrgj0h 5 4 : : : cord-334315-ymkrgj0h 5 5 10.1371 10.1371 CD cord-334315-ymkrgj0h 5 6 / / SYM cord-334315-ymkrgj0h 5 7 journal.ppat.1003762 journal.ppat.1003762 NN cord-334315-ymkrgj0h 5 8 sha sha NNP cord-334315-ymkrgj0h 5 9 : : : cord-334315-ymkrgj0h 5 10 6e1a04ccbbb614c9a28dd37899d7537f907028a8 6e1a04ccbbb614c9a28dd37899d7537f907028a8 CD cord-334315-ymkrgj0h 5 11 doc_id doc_id CD cord-334315-ymkrgj0h 5 12 : : : cord-334315-ymkrgj0h 5 13 334315 334315 CD cord-334315-ymkrgj0h 5 14 cord_uid cord_uid NNS cord-334315-ymkrgj0h 5 15 : : : cord-334315-ymkrgj0h 6 1 ymkrgj0h ymkrgj0h NNP cord-334315-ymkrgj0h 6 2 nan nan NNP cord-334315-ymkrgj0h 7 1 As as IN cord-334315-ymkrgj0h 7 2 our -PRON- PRP$ cord-334315-ymkrgj0h 7 3 appreciation appreciation NN cord-334315-ymkrgj0h 7 4 increases increase VBZ cord-334315-ymkrgj0h 7 5 for for IN cord-334315-ymkrgj0h 7 6 the the DT cord-334315-ymkrgj0h 7 7 pervasive pervasive JJ cord-334315-ymkrgj0h 7 8 nature nature NN cord-334315-ymkrgj0h 7 9 of of IN cord-334315-ymkrgj0h 7 10 transcription transcription NN cord-334315-ymkrgj0h 7 11 in in IN cord-334315-ymkrgj0h 7 12 the the DT cord-334315-ymkrgj0h 7 13 cell cell NN cord-334315-ymkrgj0h 7 14 , , , cord-334315-ymkrgj0h 7 15 so so RB cord-334315-ymkrgj0h 7 16 too too RB cord-334315-ymkrgj0h 7 17 has have VBZ cord-334315-ymkrgj0h 7 18 our -PRON- PRP$ cord-334315-ymkrgj0h 7 19 appreciation appreciation NN cord-334315-ymkrgj0h 7 20 for for IN cord-334315-ymkrgj0h 7 21 the the DT cord-334315-ymkrgj0h 7 22 major major JJ cord-334315-ymkrgj0h 7 23 role role NN cord-334315-ymkrgj0h 7 24 of of IN cord-334315-ymkrgj0h 7 25 RNA RNA NNP cord-334315-ymkrgj0h 7 26 decay decay NN cord-334315-ymkrgj0h 7 27 / / SYM cord-334315-ymkrgj0h 7 28 stability stability NN cord-334315-ymkrgj0h 7 29 in in IN cord-334315-ymkrgj0h 7 30 regulating regulate VBG cord-334315-ymkrgj0h 7 31 both both CC cord-334315-ymkrgj0h 7 32 the the DT cord-334315-ymkrgj0h 7 33 quantity quantity NN cord-334315-ymkrgj0h 7 34 and and CC cord-334315-ymkrgj0h 7 35 the the DT cord-334315-ymkrgj0h 7 36 quality quality NN cord-334315-ymkrgj0h 7 37 of of IN cord-334315-ymkrgj0h 7 38 gene gene NN cord-334315-ymkrgj0h 7 39 expression expression NN cord-334315-ymkrgj0h 7 40 . . . cord-334315-ymkrgj0h 8 1 As as RB cord-334315-ymkrgj0h 8 2 soon soon RB cord-334315-ymkrgj0h 8 3 as as IN cord-334315-ymkrgj0h 8 4 viral viral JJ cord-334315-ymkrgj0h 8 5 RNAs rna NNS cord-334315-ymkrgj0h 8 6 appear appear VBP cord-334315-ymkrgj0h 8 7 in in IN cord-334315-ymkrgj0h 8 8 the the DT cord-334315-ymkrgj0h 8 9 cell cell NN cord-334315-ymkrgj0h 8 10 , , , cord-334315-ymkrgj0h 8 11 they -PRON- PRP cord-334315-ymkrgj0h 8 12 must must MD cord-334315-ymkrgj0h 8 13 be be VB cord-334315-ymkrgj0h 8 14 prepared prepared JJ cord-334315-ymkrgj0h 8 15 to to TO cord-334315-ymkrgj0h 8 16 combat combat VB cord-334315-ymkrgj0h 8 17 or or CC cord-334315-ymkrgj0h 8 18 avoid avoid VB cord-334315-ymkrgj0h 8 19 cellular cellular JJ cord-334315-ymkrgj0h 8 20 RNA RNA NNP cord-334315-ymkrgj0h 8 21 decay decay NN cord-334315-ymkrgj0h 8 22 pathways pathway NNS cord-334315-ymkrgj0h 8 23 . . . cord-334315-ymkrgj0h 9 1 This this DT cord-334315-ymkrgj0h 9 2 review review NN cord-334315-ymkrgj0h 9 3 describes describe VBZ cord-334315-ymkrgj0h 9 4 the the DT cord-334315-ymkrgj0h 9 5 myriad myriad JJ cord-334315-ymkrgj0h 9 6 ways way NNS cord-334315-ymkrgj0h 9 7 that that WDT cord-334315-ymkrgj0h 9 8 viruses virus NNS cord-334315-ymkrgj0h 9 9 deal deal VBP cord-334315-ymkrgj0h 9 10 with with IN cord-334315-ymkrgj0h 9 11 the the DT cord-334315-ymkrgj0h 9 12 general general JJ cord-334315-ymkrgj0h 9 13 host host NN cord-334315-ymkrgj0h 9 14 RNA RNA NNP cord-334315-ymkrgj0h 9 15 decay decay NN cord-334315-ymkrgj0h 9 16 machinery machinery NN cord-334315-ymkrgj0h 9 17 that that WDT cord-334315-ymkrgj0h 9 18 is be VBZ cord-334315-ymkrgj0h 9 19 active active JJ cord-334315-ymkrgj0h 9 20 in in IN cord-334315-ymkrgj0h 9 21 the the DT cord-334315-ymkrgj0h 9 22 cell cell NN cord-334315-ymkrgj0h 9 23 immediately immediately RB cord-334315-ymkrgj0h 9 24 upon upon IN cord-334315-ymkrgj0h 9 25 viral viral JJ cord-334315-ymkrgj0h 9 26 infection infection NN cord-334315-ymkrgj0h 9 27 - - : cord-334315-ymkrgj0h 9 28 turning turn VBG cord-334315-ymkrgj0h 9 29 what what WP cord-334315-ymkrgj0h 9 30 , , , cord-334315-ymkrgj0h 9 31 at at IN cord-334315-ymkrgj0h 9 32 first first RB cord-334315-ymkrgj0h 9 33 , , , cord-334315-ymkrgj0h 9 34 appears appear VBZ cord-334315-ymkrgj0h 9 35 to to TO cord-334315-ymkrgj0h 9 36 be be VB cord-334315-ymkrgj0h 9 37 very very RB cord-334315-ymkrgj0h 9 38 hostile hostile JJ cord-334315-ymkrgj0h 9 39 territory territory NN cord-334315-ymkrgj0h 9 40 for for IN cord-334315-ymkrgj0h 9 41 a a DT cord-334315-ymkrgj0h 9 42 foreign foreign JJ cord-334315-ymkrgj0h 9 43 transcript transcript NN cord-334315-ymkrgj0h 9 44 into into IN cord-334315-ymkrgj0h 9 45 a a DT cord-334315-ymkrgj0h 9 46 sort sort NN cord-334315-ymkrgj0h 9 47 of of IN cord-334315-ymkrgj0h 9 48 ' ' '' cord-334315-ymkrgj0h 9 49 ' ' '' cord-334315-ymkrgj0h 9 50 promised promise VBN cord-334315-ymkrgj0h 9 51 land land NN cord-334315-ymkrgj0h 9 52 ' ' '' cord-334315-ymkrgj0h 9 53 ' ' '' cord-334315-ymkrgj0h 9 54 for for IN cord-334315-ymkrgj0h 9 55 viral viral JJ cord-334315-ymkrgj0h 9 56 gene gene NN cord-334315-ymkrgj0h 9 57 expression expression NN cord-334315-ymkrgj0h 9 58 . . . cord-334315-ymkrgj0h 10 1 It -PRON- PRP cord-334315-ymkrgj0h 10 2 is be VBZ cord-334315-ymkrgj0h 10 3 interesting interesting JJ cord-334315-ymkrgj0h 10 4 to to TO cord-334315-ymkrgj0h 10 5 note note VB cord-334315-ymkrgj0h 10 6 that that IN cord-334315-ymkrgj0h 10 7 cells cell NNS cord-334315-ymkrgj0h 10 8 likely likely RB cord-334315-ymkrgj0h 10 9 try try VBP cord-334315-ymkrgj0h 10 10 to to TO cord-334315-ymkrgj0h 10 11 adapt adapt VB cord-334315-ymkrgj0h 10 12 to to IN cord-334315-ymkrgj0h 10 13 this this DT cord-334315-ymkrgj0h 10 14 viral viral JJ cord-334315-ymkrgj0h 10 15 interference interference NN cord-334315-ymkrgj0h 10 16 with with IN cord-334315-ymkrgj0h 10 17 the the DT cord-334315-ymkrgj0h 10 18 general general NNP cord-334315-ymkrgj0h 10 19 RNA RNA NNP cord-334315-ymkrgj0h 10 20 decay decay NN cord-334315-ymkrgj0h 10 21 machinery machinery NN cord-334315-ymkrgj0h 10 22 by by IN cord-334315-ymkrgj0h 10 23 inducing induce VBG cord-334315-ymkrgj0h 10 24 a a DT cord-334315-ymkrgj0h 10 25 variety variety NN cord-334315-ymkrgj0h 10 26 of of IN cord-334315-ymkrgj0h 10 27 novel novel JJ cord-334315-ymkrgj0h 10 28 RNases rnase NNS cord-334315-ymkrgj0h 10 29 as as IN cord-334315-ymkrgj0h 10 30 part part NN cord-334315-ymkrgj0h 10 31 of of IN cord-334315-ymkrgj0h 10 32 a a DT cord-334315-ymkrgj0h 10 33 molecular molecular JJ cord-334315-ymkrgj0h 10 34 arms arm NNS cord-334315-ymkrgj0h 10 35 race race NN cord-334315-ymkrgj0h 10 36 . . . cord-334315-ymkrgj0h 11 1 The the DT cord-334315-ymkrgj0h 11 2 cellular cellular JJ cord-334315-ymkrgj0h 11 3 RNA RNA NNP cord-334315-ymkrgj0h 11 4 decay decay NN cord-334315-ymkrgj0h 11 5 machinery machinery NN cord-334315-ymkrgj0h 11 6 constantly constantly RB cord-334315-ymkrgj0h 11 7 monitors monitor VBZ cord-334315-ymkrgj0h 11 8 transcripts transcript NNS cord-334315-ymkrgj0h 11 9 , , , cord-334315-ymkrgj0h 11 10 from from IN cord-334315-ymkrgj0h 11 11 the the DT cord-334315-ymkrgj0h 11 12 time time NN cord-334315-ymkrgj0h 11 13 they -PRON- PRP cord-334315-ymkrgj0h 11 14 are be VBP cord-334315-ymkrgj0h 11 15 synthesized synthesize VBN cord-334315-ymkrgj0h 11 16 in in IN cord-334315-ymkrgj0h 11 17 the the DT cord-334315-ymkrgj0h 11 18 nucleus nucleus NN cord-334315-ymkrgj0h 11 19 until until IN cord-334315-ymkrgj0h 11 20 the the DT cord-334315-ymkrgj0h 11 21 end end NN cord-334315-ymkrgj0h 11 22 of of IN cord-334315-ymkrgj0h 11 23 their -PRON- PRP$ cord-334315-ymkrgj0h 11 24 lifespan lifespan NN cord-334315-ymkrgj0h 11 25 in in IN cord-334315-ymkrgj0h 11 26 the the DT cord-334315-ymkrgj0h 11 27 cytoplasm cytoplasm NN cord-334315-ymkrgj0h 11 28 . . . cord-334315-ymkrgj0h 12 1 Aberrant aberrant JJ cord-334315-ymkrgj0h 12 2 products product NNS cord-334315-ymkrgj0h 12 3 of of IN cord-334315-ymkrgj0h 12 4 transcription transcription NN cord-334315-ymkrgj0h 12 5 initiation initiation NN cord-334315-ymkrgj0h 12 6 ( ( -LRB- cord-334315-ymkrgj0h 12 7 e.g. e.g. RB cord-334315-ymkrgj0h 12 8 PROMPTS PROMPTS NNP cord-334315-ymkrgj0h 12 9 ) ) -RRB- cord-334315-ymkrgj0h 12 10 , , , cord-334315-ymkrgj0h 12 11 capping capping NN cord-334315-ymkrgj0h 12 12 , , , cord-334315-ymkrgj0h 12 13 and and CC cord-334315-ymkrgj0h 12 14 termination termination NN cord-334315-ymkrgj0h 12 15 are be VBP cord-334315-ymkrgj0h 12 16 quickly quickly RB cord-334315-ymkrgj0h 12 17 degraded degrade VBN cord-334315-ymkrgj0h 12 18 by by IN cord-334315-ymkrgj0h 12 19 nuclear nuclear JJ cord-334315-ymkrgj0h 12 20 RNA RNA NNP cord-334315-ymkrgj0h 12 21 quality quality NN cord-334315-ymkrgj0h 12 22 control control NN cord-334315-ymkrgj0h 12 23 surveillance surveillance NN cord-334315-ymkrgj0h 12 24 complexes complex NNS cord-334315-ymkrgj0h 12 25 . . . cord-334315-ymkrgj0h 13 1 Misfolded Misfolded NNP cord-334315-ymkrgj0h 13 2 , , , cord-334315-ymkrgj0h 13 3 ' ' '' cord-334315-ymkrgj0h 13 4 ' ' '' cord-334315-ymkrgj0h 13 5 mis''-translated mis''-translate VBN cord-334315-ymkrgj0h 14 1 ( ( -LRB- cord-334315-ymkrgj0h 14 2 e.g. e.g. RB cord-334315-ymkrgj0h 14 3 mRNAs mRNAs -RRB- cord-334315-ymkrgj0h 14 4 with with IN cord-334315-ymkrgj0h 14 5 a a DT cord-334315-ymkrgj0h 14 6 premature premature JJ cord-334315-ymkrgj0h 14 7 termination termination NN cord-334315-ymkrgj0h 14 8 codon codon NN cord-334315-ymkrgj0h 14 9 ) ) -RRB- cord-334315-ymkrgj0h 14 10 , , , cord-334315-ymkrgj0h 14 11 and and CC cord-334315-ymkrgj0h 14 12 mispackaged mispackage VBN cord-334315-ymkrgj0h 14 13 mRNAs mRNAs NNPS cord-334315-ymkrgj0h 14 14 are be VBP cord-334315-ymkrgj0h 14 15 also also RB cord-334315-ymkrgj0h 14 16 quickly quickly RB cord-334315-ymkrgj0h 14 17 degraded degrade VBN cord-334315-ymkrgj0h 14 18 in in IN cord-334315-ymkrgj0h 14 19 the the DT cord-334315-ymkrgj0h 14 20 cytoplasm cytoplasm NN cord-334315-ymkrgj0h 14 21 . . . cord-334315-ymkrgj0h 15 1 In in IN cord-334315-ymkrgj0h 15 2 addition addition NN cord-334315-ymkrgj0h 15 3 to to IN cord-334315-ymkrgj0h 15 4 removing remove VBG cord-334315-ymkrgj0h 15 5 aberrant aberrant JJ cord-334315-ymkrgj0h 15 6 mRNAs mRNAs NNPS cord-334315-ymkrgj0h 15 7 , , , cord-334315-ymkrgj0h 15 8 up up IN cord-334315-ymkrgj0h 15 9 to to TO cord-334315-ymkrgj0h 15 10 50 50 CD cord-334315-ymkrgj0h 15 11 % % NN cord-334315-ymkrgj0h 15 12 of of IN cord-334315-ymkrgj0h 15 13 cellular cellular JJ cord-334315-ymkrgj0h 15 14 gene gene NN cord-334315-ymkrgj0h 15 15 expression expression NN cord-334315-ymkrgj0h 15 16 may may MD cord-334315-ymkrgj0h 15 17 be be VB cord-334315-ymkrgj0h 15 18 controlled control VBN cord-334315-ymkrgj0h 15 19 by by IN cord-334315-ymkrgj0h 15 20 changes change NNS cord-334315-ymkrgj0h 15 21 in in IN cord-334315-ymkrgj0h 15 22 mRNA mRNA NNP cord-334315-ymkrgj0h 15 23 stability stability NN cord-334315-ymkrgj0h 15 24 . . . cord-334315-ymkrgj0h 16 1 When when WRB cord-334315-ymkrgj0h 16 2 a a DT cord-334315-ymkrgj0h 16 3 typical typical JJ cord-334315-ymkrgj0h 16 4 cellular cellular JJ cord-334315-ymkrgj0h 16 5 mRNA mrna NN cord-334315-ymkrgj0h 16 6 is be VBZ cord-334315-ymkrgj0h 16 7 targeted target VBN cord-334315-ymkrgj0h 16 8 for for IN cord-334315-ymkrgj0h 16 9 decay decay NN cord-334315-ymkrgj0h 16 10 , , , cord-334315-ymkrgj0h 16 11 it -PRON- PRP cord-334315-ymkrgj0h 16 12 initially initially RB cord-334315-ymkrgj0h 16 13 undergoes undergo VBZ cord-334315-ymkrgj0h 16 14 deadenylation deadenylation NN cord-334315-ymkrgj0h 16 15 - - : cord-334315-ymkrgj0h 16 16 the the DT cord-334315-ymkrgj0h 16 17 removal removal NN cord-334315-ymkrgj0h 16 18 of of IN cord-334315-ymkrgj0h 16 19 the the DT cord-334315-ymkrgj0h 16 20 39 39 CD cord-334315-ymkrgj0h 16 21 poly(A poly(a JJ cord-334315-ymkrgj0h 16 22 ) ) -RRB- cord-334315-ymkrgj0h 16 23 tail tail NN cord-334315-ymkrgj0h 16 24 . . . cord-334315-ymkrgj0h 17 1 The the DT cord-334315-ymkrgj0h 17 2 mRNA mrna NN cord-334315-ymkrgj0h 17 3 is be VBZ cord-334315-ymkrgj0h 17 4 then then RB cord-334315-ymkrgj0h 17 5 subject subject JJ cord-334315-ymkrgj0h 17 6 to to IN cord-334315-ymkrgj0h 17 7 processive processive JJ cord-334315-ymkrgj0h 17 8 exonucleolytic exonucleolytic JJ cord-334315-ymkrgj0h 17 9 degradation degradation NN cord-334315-ymkrgj0h 17 10 in in IN cord-334315-ymkrgj0h 17 11 either either CC cord-334315-ymkrgj0h 17 12 the the DT cord-334315-ymkrgj0h 17 13 39 39 CD cord-334315-ymkrgj0h 17 14 - - SYM cord-334315-ymkrgj0h 17 15 59 59 CD cord-334315-ymkrgj0h 17 16 direction direction NN cord-334315-ymkrgj0h 17 17 by by IN cord-334315-ymkrgj0h 17 18 the the DT cord-334315-ymkrgj0h 17 19 exosome exosome NN cord-334315-ymkrgj0h 17 20 or or CC cord-334315-ymkrgj0h 17 21 Dis3L2 Dis3L2 NNP cord-334315-ymkrgj0h 17 22 , , , cord-334315-ymkrgj0h 17 23 or or CC cord-334315-ymkrgj0h 17 24 it -PRON- PRP cord-334315-ymkrgj0h 17 25 is be VBZ cord-334315-ymkrgj0h 17 26 marked mark VBN cord-334315-ymkrgj0h 17 27 by by IN cord-334315-ymkrgj0h 17 28 the the DT cord-334315-ymkrgj0h 17 29 LSm1 LSm1 NNP cord-334315-ymkrgj0h 17 30 - - HYPH cord-334315-ymkrgj0h 17 31 7 7 CD cord-334315-ymkrgj0h 17 32 / / SYM cord-334315-ymkrgj0h 17 33 Pat1 Pat1 NNP cord-334315-ymkrgj0h 17 34 complex complex NN cord-334315-ymkrgj0h 17 35 for for IN cord-334315-ymkrgj0h 17 36 decapping decapping NN cord-334315-ymkrgj0h 17 37 by by IN cord-334315-ymkrgj0h 17 38 Dcp1/2 Dcp1/2 NNP cord-334315-ymkrgj0h 17 39 and and CC cord-334315-ymkrgj0h 17 40 degraded degrade VBN cord-334315-ymkrgj0h 17 41 in in IN cord-334315-ymkrgj0h 17 42 the the DT cord-334315-ymkrgj0h 17 43 59 59 CD cord-334315-ymkrgj0h 17 44 - - SYM cord-334315-ymkrgj0h 17 45 39 39 CD cord-334315-ymkrgj0h 17 46 direction direction NN cord-334315-ymkrgj0h 17 47 by by IN cord-334315-ymkrgj0h 17 48 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 17 49 [ [ -LRB- cord-334315-ymkrgj0h 17 50 1 1 CD cord-334315-ymkrgj0h 17 51 ] ] -RRB- cord-334315-ymkrgj0h 17 52 . . . cord-334315-ymkrgj0h 18 1 When when WRB cord-334315-ymkrgj0h 18 2 the the DT cord-334315-ymkrgj0h 18 3 transcripts transcript NNS cord-334315-ymkrgj0h 18 4 of of IN cord-334315-ymkrgj0h 18 5 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 18 6 viruses virus NNS cord-334315-ymkrgj0h 18 7 are be VBP cord-334315-ymkrgj0h 18 8 generated generate VBN cord-334315-ymkrgj0h 18 9 , , , cord-334315-ymkrgj0h 18 10 they -PRON- PRP cord-334315-ymkrgj0h 18 11 must must MD cord-334315-ymkrgj0h 18 12 actively actively RB cord-334315-ymkrgj0h 18 13 avoid avoid VB cord-334315-ymkrgj0h 18 14 or or CC cord-334315-ymkrgj0h 18 15 overcome overcome VB cord-334315-ymkrgj0h 18 16 the the DT cord-334315-ymkrgj0h 18 17 assault assault NN cord-334315-ymkrgj0h 18 18 by by IN cord-334315-ymkrgj0h 18 19 these these DT cord-334315-ymkrgj0h 18 20 aggressive aggressive JJ cord-334315-ymkrgj0h 18 21 cellular cellular JJ cord-334315-ymkrgj0h 18 22 mRNA mrna NN cord-334315-ymkrgj0h 18 23 decay decay NN cord-334315-ymkrgj0h 18 24 complexes complex NNS cord-334315-ymkrgj0h 18 25 in in IN cord-334315-ymkrgj0h 18 26 order order NN cord-334315-ymkrgj0h 18 27 to to TO cord-334315-ymkrgj0h 18 28 be be VB cord-334315-ymkrgj0h 18 29 translated translate VBN cord-334315-ymkrgj0h 18 30 and and CC cord-334315-ymkrgj0h 18 31 effectively effectively RB cord-334315-ymkrgj0h 18 32 generate generate VB cord-334315-ymkrgj0h 18 33 virions virion NNS cord-334315-ymkrgj0h 18 34 . . . cord-334315-ymkrgj0h 19 1 It -PRON- PRP cord-334315-ymkrgj0h 19 2 should should MD cord-334315-ymkrgj0h 19 3 be be VB cord-334315-ymkrgj0h 19 4 easy easy JJ cord-334315-ymkrgj0h 19 5 for for IN cord-334315-ymkrgj0h 19 6 the the DT cord-334315-ymkrgj0h 19 7 cellular cellular JJ cord-334315-ymkrgj0h 19 8 RNA RNA NNP cord-334315-ymkrgj0h 19 9 decay decay NN cord-334315-ymkrgj0h 19 10 machinery machinery NN cord-334315-ymkrgj0h 19 11 to to TO cord-334315-ymkrgj0h 19 12 recognize recognize VB cord-334315-ymkrgj0h 19 13 these these DT cord-334315-ymkrgj0h 19 14 foreign foreign JJ cord-334315-ymkrgj0h 19 15 transcripts transcript NNS cord-334315-ymkrgj0h 19 16 - - : cord-334315-ymkrgj0h 19 17 typical typical JJ cord-334315-ymkrgj0h 19 18 host host NN cord-334315-ymkrgj0h 19 19 mRNAs mrnas CD cord-334315-ymkrgj0h 19 20 , , , cord-334315-ymkrgj0h 19 21 for for IN cord-334315-ymkrgj0h 19 22 example example NN cord-334315-ymkrgj0h 19 23 , , , cord-334315-ymkrgj0h 19 24 are be VBP cord-334315-ymkrgj0h 19 25 assembled assemble VBN cord-334315-ymkrgj0h 19 26 into into IN cord-334315-ymkrgj0h 19 27 characteristic characteristic JJ cord-334315-ymkrgj0h 19 28 ribonucleoprotein ribonucleoprotein NN cord-334315-ymkrgj0h 19 29 complexes complex NNS cord-334315-ymkrgj0h 19 30 in in IN cord-334315-ymkrgj0h 19 31 the the DT cord-334315-ymkrgj0h 19 32 nucleus nucleus NN cord-334315-ymkrgj0h 19 33 , , , cord-334315-ymkrgj0h 19 34 but but CC cord-334315-ymkrgj0h 19 35 the the DT cord-334315-ymkrgj0h 19 36 RNAs rna NNS cord-334315-ymkrgj0h 19 37 of of IN cord-334315-ymkrgj0h 19 38 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 19 39 viruses virus NNS cord-334315-ymkrgj0h 19 40 never never RB cord-334315-ymkrgj0h 19 41 have have VBP cord-334315-ymkrgj0h 19 42 this this DT cord-334315-ymkrgj0h 19 43 opportunity opportunity NN cord-334315-ymkrgj0h 19 44 . . . cord-334315-ymkrgj0h 20 1 In in IN cord-334315-ymkrgj0h 20 2 addition addition NN cord-334315-ymkrgj0h 20 3 , , , cord-334315-ymkrgj0h 20 4 some some DT cord-334315-ymkrgj0h 20 5 viral viral JJ cord-334315-ymkrgj0h 20 6 RNAs rna NNS cord-334315-ymkrgj0h 20 7 do do VBP cord-334315-ymkrgj0h 20 8 not not RB cord-334315-ymkrgj0h 20 9 have have VB cord-334315-ymkrgj0h 20 10 59 59 CD cord-334315-ymkrgj0h 20 11 caps cap NNS cord-334315-ymkrgj0h 20 12 or or CC cord-334315-ymkrgj0h 20 13 poly(A poly(a JJ cord-334315-ymkrgj0h 20 14 ) ) -RRB- cord-334315-ymkrgj0h 20 15 tails tail NNS cord-334315-ymkrgj0h 20 16 , , , cord-334315-ymkrgj0h 20 17 and and CC cord-334315-ymkrgj0h 20 18 some some DT cord-334315-ymkrgj0h 20 19 have have VBP cord-334315-ymkrgj0h 20 20 multiple multiple JJ cord-334315-ymkrgj0h 20 21 open open JJ cord-334315-ymkrgj0h 20 22 reading reading NN cord-334315-ymkrgj0h 20 23 frames frame NNS cord-334315-ymkrgj0h 20 24 or or CC cord-334315-ymkrgj0h 20 25 long long JJ cord-334315-ymkrgj0h 20 26 39 39 CD cord-334315-ymkrgj0h 20 27 UTRs utr NNS cord-334315-ymkrgj0h 20 28 , , , cord-334315-ymkrgj0h 20 29 which which WDT cord-334315-ymkrgj0h 20 30 should should MD cord-334315-ymkrgj0h 20 31 target target VB cord-334315-ymkrgj0h 20 32 them -PRON- PRP cord-334315-ymkrgj0h 20 33 for for IN cord-334315-ymkrgj0h 20 34 nonsense nonsense NN cord-334315-ymkrgj0h 20 35 - - HYPH cord-334315-ymkrgj0h 20 36 mediated mediate VBN cord-334315-ymkrgj0h 20 37 decay decay NN cord-334315-ymkrgj0h 20 38 . . . cord-334315-ymkrgj0h 21 1 Yet yet RB cord-334315-ymkrgj0h 21 2 , , , cord-334315-ymkrgj0h 21 3 the the DT cord-334315-ymkrgj0h 21 4 transcripts transcript NNS cord-334315-ymkrgj0h 21 5 generated generate VBN cord-334315-ymkrgj0h 21 6 by by IN cord-334315-ymkrgj0h 21 7 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 21 8 viruses virus NNS cord-334315-ymkrgj0h 21 9 survive survive VBP cord-334315-ymkrgj0h 21 10 and and CC cord-334315-ymkrgj0h 21 11 flourish flourish VBP cord-334315-ymkrgj0h 21 12 in in IN cord-334315-ymkrgj0h 21 13 this this DT cord-334315-ymkrgj0h 21 14 hostile hostile JJ cord-334315-ymkrgj0h 21 15 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 21 16 environment environment NN cord-334315-ymkrgj0h 21 17 . . . cord-334315-ymkrgj0h 22 1 Interestingly interestingly RB cord-334315-ymkrgj0h 22 2 , , , cord-334315-ymkrgj0h 22 3 viruses virus NNS cord-334315-ymkrgj0h 22 4 do do VBP cord-334315-ymkrgj0h 22 5 more more JJR cord-334315-ymkrgj0h 22 6 than than IN cord-334315-ymkrgj0h 22 7 simply simply RB cord-334315-ymkrgj0h 22 8 mimic mimic VB cord-334315-ymkrgj0h 22 9 host host NN cord-334315-ymkrgj0h 22 10 mechanisms mechanism NNS cord-334315-ymkrgj0h 22 11 like like IN cord-334315-ymkrgj0h 22 12 polyadenylation polyadenylation NN cord-334315-ymkrgj0h 22 13 , , , cord-334315-ymkrgj0h 22 14 triple triple JJ cord-334315-ymkrgj0h 22 15 helix helix NN cord-334315-ymkrgj0h 22 16 structures structure NNS cord-334315-ymkrgj0h 22 17 , , , cord-334315-ymkrgj0h 22 18 and and CC cord-334315-ymkrgj0h 22 19 59 59 CD cord-334315-ymkrgj0h 22 20 capping cap VBG cord-334315-ymkrgj0h 22 21 to to TO cord-334315-ymkrgj0h 22 22 protect protect VB cord-334315-ymkrgj0h 22 23 their -PRON- PRP$ cord-334315-ymkrgj0h 22 24 transcripts transcript NNS cord-334315-ymkrgj0h 22 25 from from IN cord-334315-ymkrgj0h 22 26 host host NN cord-334315-ymkrgj0h 22 27 exonucleases exonuclease NNS cord-334315-ymkrgj0h 22 28 [ [ -LRB- cord-334315-ymkrgj0h 22 29 2 2 CD cord-334315-ymkrgj0h 22 30 ] ] -RRB- cord-334315-ymkrgj0h 22 31 . . . cord-334315-ymkrgj0h 23 1 Cytoplasmic Cytoplasmic NNP cord-334315-ymkrgj0h 23 2 viruses virus NNS cord-334315-ymkrgj0h 23 3 use use VBP cord-334315-ymkrgj0h 23 4 diverse diverse JJ cord-334315-ymkrgj0h 23 5 strategies strategy NNS cord-334315-ymkrgj0h 23 6 to to TO cord-334315-ymkrgj0h 23 7 overcome overcome VB cord-334315-ymkrgj0h 23 8 the the DT cord-334315-ymkrgj0h 23 9 odds odd NNS cord-334315-ymkrgj0h 23 10 and and CC cord-334315-ymkrgj0h 23 11 trick trick VB cord-334315-ymkrgj0h 23 12 the the DT cord-334315-ymkrgj0h 23 13 host host NN cord-334315-ymkrgj0h 23 14 into into IN cord-334315-ymkrgj0h 23 15 ignoring ignore VBG cord-334315-ymkrgj0h 23 16 or or CC cord-334315-ymkrgj0h 23 17 even even RB cord-334315-ymkrgj0h 23 18 , , , cord-334315-ymkrgj0h 23 19 preferentially preferentially RB cord-334315-ymkrgj0h 23 20 , , , cord-334315-ymkrgj0h 23 21 stabilizing stabilize VBG cord-334315-ymkrgj0h 23 22 their -PRON- PRP$ cord-334315-ymkrgj0h 23 23 transcripts transcript NNS cord-334315-ymkrgj0h 23 24 . . . cord-334315-ymkrgj0h 24 1 Such such JJ cord-334315-ymkrgj0h 24 2 viral viral JJ cord-334315-ymkrgj0h 24 3 RNA RNA NNP cord-334315-ymkrgj0h 24 4 trickery trickery NN cord-334315-ymkrgj0h 24 5 is be VBZ cord-334315-ymkrgj0h 24 6 a a DT cord-334315-ymkrgj0h 24 7 fascinating fascinating JJ cord-334315-ymkrgj0h 24 8 aspect aspect NN cord-334315-ymkrgj0h 24 9 of of IN cord-334315-ymkrgj0h 24 10 host host NN cord-334315-ymkrgj0h 24 11 - - HYPH cord-334315-ymkrgj0h 24 12 virus virus NN cord-334315-ymkrgj0h 24 13 interaction interaction NN cord-334315-ymkrgj0h 24 14 that that WDT cord-334315-ymkrgj0h 24 15 we -PRON- PRP cord-334315-ymkrgj0h 24 16 are be VBP cord-334315-ymkrgj0h 24 17 just just RB cord-334315-ymkrgj0h 24 18 now now RB cord-334315-ymkrgj0h 24 19 beginning begin VBG cord-334315-ymkrgj0h 24 20 to to TO cord-334315-ymkrgj0h 24 21 understand understand VB cord-334315-ymkrgj0h 24 22 . . . cord-334315-ymkrgj0h 25 1 Several several JJ cord-334315-ymkrgj0h 25 2 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 25 3 viruses virus NNS cord-334315-ymkrgj0h 25 4 directly directly RB cord-334315-ymkrgj0h 25 5 repress repress VB cord-334315-ymkrgj0h 25 6 key key JJ cord-334315-ymkrgj0h 25 7 aspects aspect NNS cord-334315-ymkrgj0h 25 8 of of IN cord-334315-ymkrgj0h 25 9 the the DT cord-334315-ymkrgj0h 25 10 cellular cellular JJ cord-334315-ymkrgj0h 25 11 RNA RNA NNP cord-334315-ymkrgj0h 25 12 decay decay NN cord-334315-ymkrgj0h 25 13 machinery machinery NN cord-334315-ymkrgj0h 25 14 to to TO cord-334315-ymkrgj0h 25 15 promote promote VB cord-334315-ymkrgj0h 25 16 viral viral JJ cord-334315-ymkrgj0h 25 17 RNA RNA NNP cord-334315-ymkrgj0h 25 18 stability stability NN cord-334315-ymkrgj0h 25 19 . . . cord-334315-ymkrgj0h 26 1 Picornaviruses picornavirus NNS cord-334315-ymkrgj0h 26 2 use use VBP cord-334315-ymkrgj0h 26 3 an an DT cord-334315-ymkrgj0h 26 4 aggressive aggressive JJ cord-334315-ymkrgj0h 26 5 mechanism mechanism NN cord-334315-ymkrgj0h 26 6 for for IN cord-334315-ymkrgj0h 26 7 suppression suppression NN cord-334315-ymkrgj0h 26 8 of of IN cord-334315-ymkrgj0h 26 9 host host NN cord-334315-ymkrgj0h 26 10 RNA RNA NNP cord-334315-ymkrgj0h 26 11 decay decay NN cord-334315-ymkrgj0h 26 12 factors factor NNS cord-334315-ymkrgj0h 26 13 . . . cord-334315-ymkrgj0h 27 1 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 27 2 , , , cord-334315-ymkrgj0h 27 3 Dcp1 Dcp1 NNP cord-334315-ymkrgj0h 27 4 , , , cord-334315-ymkrgj0h 27 5 Dcp2 Dcp2 NNP cord-334315-ymkrgj0h 27 6 , , , cord-334315-ymkrgj0h 27 7 Pan3 Pan3 NNP cord-334315-ymkrgj0h 27 8 ( ( -LRB- cord-334315-ymkrgj0h 27 9 a a DT cord-334315-ymkrgj0h 27 10 deadenylase deadenylase NN cord-334315-ymkrgj0h 27 11 ) ) -RRB- cord-334315-ymkrgj0h 27 12 , , , cord-334315-ymkrgj0h 27 13 and and CC cord-334315-ymkrgj0h 27 14 AUF1 AUF1 NNP cord-334315-ymkrgj0h 27 15 ( ( -LRB- cord-334315-ymkrgj0h 27 16 a a DT cord-334315-ymkrgj0h 27 17 factor factor NN cord-334315-ymkrgj0h 27 18 that that WDT cord-334315-ymkrgj0h 27 19 targets target VBZ cord-334315-ymkrgj0h 27 20 RNAs rna NNS cord-334315-ymkrgj0h 27 21 for for IN cord-334315-ymkrgj0h 27 22 decay decay NN cord-334315-ymkrgj0h 27 23 ) ) -RRB- cord-334315-ymkrgj0h 27 24 are be VBP cord-334315-ymkrgj0h 27 25 rapidly rapidly RB cord-334315-ymkrgj0h 27 26 degraded degrade VBN cord-334315-ymkrgj0h 27 27 during during IN cord-334315-ymkrgj0h 27 28 poliovirus poliovirus NN cord-334315-ymkrgj0h 27 29 or or CC cord-334315-ymkrgj0h 27 30 human human JJ cord-334315-ymkrgj0h 27 31 rhinovirus rhinovirus NN cord-334315-ymkrgj0h 27 32 infections infection NNS cord-334315-ymkrgj0h 27 33 by by IN cord-334315-ymkrgj0h 27 34 viral viral JJ cord-334315-ymkrgj0h 27 35 proteases protease NNS cord-334315-ymkrgj0h 27 36 and/or and/or CC cord-334315-ymkrgj0h 27 37 the the DT cord-334315-ymkrgj0h 27 38 host host NN cord-334315-ymkrgj0h 27 39 cell cell NN cord-334315-ymkrgj0h 27 40 proteasome proteasome VBN cord-334315-ymkrgj0h 27 41 [ [ -LRB- cord-334315-ymkrgj0h 27 42 3 3 CD cord-334315-ymkrgj0h 27 43 , , , cord-334315-ymkrgj0h 27 44 4 4 CD cord-334315-ymkrgj0h 27 45 ] ] -RRB- cord-334315-ymkrgj0h 27 46 . . . cord-334315-ymkrgj0h 28 1 The the DT cord-334315-ymkrgj0h 28 2 importance importance NN cord-334315-ymkrgj0h 28 3 of of IN cord-334315-ymkrgj0h 28 4 this this DT cord-334315-ymkrgj0h 28 5 suppression suppression NN cord-334315-ymkrgj0h 28 6 has have VBZ cord-334315-ymkrgj0h 28 7 recently recently RB cord-334315-ymkrgj0h 28 8 been be VBN cord-334315-ymkrgj0h 28 9 demonstrated demonstrate VBN cord-334315-ymkrgj0h 28 10 through through IN cord-334315-ymkrgj0h 28 11 the the DT cord-334315-ymkrgj0h 28 12 negative negative JJ cord-334315-ymkrgj0h 28 13 effects effect NNS cord-334315-ymkrgj0h 28 14 that that WDT cord-334315-ymkrgj0h 28 15 AUF1 AUF1 NNP cord-334315-ymkrgj0h 28 16 has have VBZ cord-334315-ymkrgj0h 28 17 on on IN cord-334315-ymkrgj0h 28 18 picornavirus picornavirus NN cord-334315-ymkrgj0h 28 19 replication replication NN cord-334315-ymkrgj0h 28 20 [ [ -LRB- cord-334315-ymkrgj0h 28 21 5 5 CD cord-334315-ymkrgj0h 28 22 ] ] -RRB- cord-334315-ymkrgj0h 28 23 . . . cord-334315-ymkrgj0h 29 1 The the DT cord-334315-ymkrgj0h 29 2 dispersal dispersal NN cord-334315-ymkrgj0h 29 3 of of IN cord-334315-ymkrgj0h 29 4 P p NN cord-334315-ymkrgj0h 29 5 - - HYPH cord-334315-ymkrgj0h 29 6 bodies body NNS cord-334315-ymkrgj0h 29 7 ( ( -LRB- cord-334315-ymkrgj0h 29 8 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 29 9 aggregates aggregate NNS cord-334315-ymkrgj0h 29 10 of of IN cord-334315-ymkrgj0h 29 11 host host NN cord-334315-ymkrgj0h 29 12 RNA RNA NNP cord-334315-ymkrgj0h 29 13 decay decay NN cord-334315-ymkrgj0h 29 14 factors factor NNS cord-334315-ymkrgj0h 29 15 ) ) -RRB- cord-334315-ymkrgj0h 29 16 in in IN cord-334315-ymkrgj0h 29 17 several several JJ cord-334315-ymkrgj0h 29 18 viral viral JJ cord-334315-ymkrgj0h 29 19 infections infection NNS cord-334315-ymkrgj0h 29 20 is be VBZ cord-334315-ymkrgj0h 29 21 also also RB cord-334315-ymkrgj0h 29 22 evidence evidence NN cord-334315-ymkrgj0h 29 23 of of IN cord-334315-ymkrgj0h 29 24 disruption disruption NN cord-334315-ymkrgj0h 29 25 of of IN cord-334315-ymkrgj0h 29 26 cellular cellular JJ cord-334315-ymkrgj0h 29 27 RNA RNA NNP cord-334315-ymkrgj0h 29 28 decay decay NN cord-334315-ymkrgj0h 29 29 activities activity NNS cord-334315-ymkrgj0h 29 30 [ [ -LRB- cord-334315-ymkrgj0h 29 31 6 6 CD cord-334315-ymkrgj0h 29 32 ] ] -RRB- cord-334315-ymkrgj0h 29 33 . . . cord-334315-ymkrgj0h 30 1 Alternatively alternatively RB cord-334315-ymkrgj0h 30 2 , , , cord-334315-ymkrgj0h 30 3 arthropod arthropod NN cord-334315-ymkrgj0h 30 4 - - HYPH cord-334315-ymkrgj0h 30 5 borne bear VBN cord-334315-ymkrgj0h 30 6 flaviviruses flavivirus NNS cord-334315-ymkrgj0h 30 7 , , , cord-334315-ymkrgj0h 30 8 including include VBG cord-334315-ymkrgj0h 30 9 West West NNP cord-334315-ymkrgj0h 30 10 Nile Nile NNP cord-334315-ymkrgj0h 30 11 virus virus NN cord-334315-ymkrgj0h 30 12 ( ( -LRB- cord-334315-ymkrgj0h 30 13 WNV WNV NNP cord-334315-ymkrgj0h 30 14 ) ) -RRB- cord-334315-ymkrgj0h 30 15 , , , cord-334315-ymkrgj0h 30 16 generate generate VBP cord-334315-ymkrgj0h 30 17 a a DT cord-334315-ymkrgj0h 30 18 large large JJ cord-334315-ymkrgj0h 30 19 amount amount NN cord-334315-ymkrgj0h 30 20 of of IN cord-334315-ymkrgj0h 30 21 a a DT cord-334315-ymkrgj0h 30 22 short short JJ cord-334315-ymkrgj0h 30 23 subgenomic subgenomic NNP cord-334315-ymkrgj0h 30 24 RNA RNA NNP cord-334315-ymkrgj0h 30 25 ( ( -LRB- cord-334315-ymkrgj0h 30 26 sfRNA sfrna NN cord-334315-ymkrgj0h 30 27 ) ) -RRB- cord-334315-ymkrgj0h 30 28 by by IN cord-334315-ymkrgj0h 30 29 stalling stall VBG cord-334315-ymkrgj0h 30 30 the the DT cord-334315-ymkrgj0h 30 31 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 30 32 59 59 CD cord-334315-ymkrgj0h 30 33 - - SYM cord-334315-ymkrgj0h 30 34 39 39 CD cord-334315-ymkrgj0h 30 35 exoribonuclease exoribonuclease NN cord-334315-ymkrgj0h 30 36 on on IN cord-334315-ymkrgj0h 30 37 pseudoknot pseudoknot NNP cord-334315-ymkrgj0h 30 38 - - HYPH cord-334315-ymkrgj0h 30 39 like like JJ cord-334315-ymkrgj0h 30 40 structures structure NNS cord-334315-ymkrgj0h 30 41 in in IN cord-334315-ymkrgj0h 30 42 the the DT cord-334315-ymkrgj0h 30 43 viral viral JJ cord-334315-ymkrgj0h 30 44 39 39 CD cord-334315-ymkrgj0h 30 45 UTR UTR NNP cord-334315-ymkrgj0h 30 46 [ [ -LRB- cord-334315-ymkrgj0h 30 47 7 7 CD cord-334315-ymkrgj0h 30 48 , , , cord-334315-ymkrgj0h 30 49 8 8 CD cord-334315-ymkrgj0h 30 50 ] ] -RRB- cord-334315-ymkrgj0h 30 51 . . . cord-334315-ymkrgj0h 31 1 Interestingly interestingly RB cord-334315-ymkrgj0h 31 2 , , , cord-334315-ymkrgj0h 31 3 stalling stall VBG cord-334315-ymkrgj0h 31 4 of of IN cord-334315-ymkrgj0h 31 5 Xrn1 xrn1 NN cord-334315-ymkrgj0h 31 6 on on IN cord-334315-ymkrgj0h 31 7 the the DT cord-334315-ymkrgj0h 31 8 viral viral JJ cord-334315-ymkrgj0h 31 9 39 39 CD cord-334315-ymkrgj0h 31 10 UTR UTR NNP cord-334315-ymkrgj0h 31 11 also also RB cord-334315-ymkrgj0h 31 12 inactivates inactivate VBZ cord-334315-ymkrgj0h 31 13 the the DT cord-334315-ymkrgj0h 31 14 enzyme enzyme NN cord-334315-ymkrgj0h 31 15 , , , cord-334315-ymkrgj0h 31 16 presumably presumably RB cord-334315-ymkrgj0h 31 17 due due IN cord-334315-ymkrgj0h 31 18 to to IN cord-334315-ymkrgj0h 31 19 its -PRON- PRP$ cord-334315-ymkrgj0h 31 20 slow slow JJ cord-334315-ymkrgj0h 31 21 release release NN cord-334315-ymkrgj0h 31 22 from from IN cord-334315-ymkrgj0h 31 23 sfRNA sfRNA NNS cord-334315-ymkrgj0h 31 24 [ [ -LRB- cord-334315-ymkrgj0h 31 25 9 9 CD cord-334315-ymkrgj0h 31 26 ] ] -RRB- cord-334315-ymkrgj0h 31 27 . . . cord-334315-ymkrgj0h 32 1 The the DT cord-334315-ymkrgj0h 32 2 repression repression NN cord-334315-ymkrgj0h 32 3 of of IN cord-334315-ymkrgj0h 32 4 Xrn1 xrn1 NN cord-334315-ymkrgj0h 32 5 by by IN cord-334315-ymkrgj0h 32 6 the the DT cord-334315-ymkrgj0h 32 7 generation generation NN cord-334315-ymkrgj0h 32 8 of of IN cord-334315-ymkrgj0h 32 9 sfRNA sfrna NN cord-334315-ymkrgj0h 32 10 is be VBZ cord-334315-ymkrgj0h 32 11 very very RB cord-334315-ymkrgj0h 32 12 important important JJ cord-334315-ymkrgj0h 32 13 in in IN cord-334315-ymkrgj0h 32 14 a a DT cord-334315-ymkrgj0h 32 15 flavivirus flavivirus JJ cord-334315-ymkrgj0h 32 16 infection infection NN cord-334315-ymkrgj0h 32 17 . . . cord-334315-ymkrgj0h 33 1 WNV WNV NNP cord-334315-ymkrgj0h 33 2 variants variant NNS cord-334315-ymkrgj0h 33 3 that that WDT cord-334315-ymkrgj0h 33 4 can can MD cord-334315-ymkrgj0h 33 5 not not RB cord-334315-ymkrgj0h 33 6 effectively effectively RB cord-334315-ymkrgj0h 33 7 form form VB cord-334315-ymkrgj0h 33 8 sfRNA sfRNA NNS cord-334315-ymkrgj0h 33 9 show show NN cord-334315-ymkrgj0h 33 10 defects defect NNS cord-334315-ymkrgj0h 33 11 in in IN cord-334315-ymkrgj0h 33 12 viral viral JJ cord-334315-ymkrgj0h 33 13 growth growth NN cord-334315-ymkrgj0h 33 14 in in IN cord-334315-ymkrgj0h 33 15 certain certain JJ cord-334315-ymkrgj0h 33 16 cell cell NN cord-334315-ymkrgj0h 33 17 types type NNS cord-334315-ymkrgj0h 33 18 and and CC cord-334315-ymkrgj0h 33 19 reduced reduced JJ cord-334315-ymkrgj0h 33 20 cytopathology cytopathology NN cord-334315-ymkrgj0h 33 21 [ [ -LRB- cord-334315-ymkrgj0h 33 22 8 8 CD cord-334315-ymkrgj0h 33 23 , , , cord-334315-ymkrgj0h 33 24 10 10 CD cord-334315-ymkrgj0h 33 25 ] ] -RRB- cord-334315-ymkrgj0h 33 26 . . . cord-334315-ymkrgj0h 34 1 Disparate Disparate NNP cord-334315-ymkrgj0h 34 2 RNA RNA NNP cord-334315-ymkrgj0h 34 3 viruses virus NNS cord-334315-ymkrgj0h 34 4 have have VBP cord-334315-ymkrgj0h 34 5 , , , cord-334315-ymkrgj0h 34 6 therefore therefore RB cord-334315-ymkrgj0h 34 7 , , , cord-334315-ymkrgj0h 34 8 evolved evolve VBD cord-334315-ymkrgj0h 34 9 unique unique JJ cord-334315-ymkrgj0h 34 10 mechanisms mechanism NNS cord-334315-ymkrgj0h 34 11 by by IN cord-334315-ymkrgj0h 34 12 which which WDT cord-334315-ymkrgj0h 34 13 they -PRON- PRP cord-334315-ymkrgj0h 34 14 disarm disarm VBP cord-334315-ymkrgj0h 34 15 host host NN cord-334315-ymkrgj0h 34 16 RNA RNA NNP cord-334315-ymkrgj0h 34 17 decay decay NN cord-334315-ymkrgj0h 34 18 pathways pathway NNS cord-334315-ymkrgj0h 34 19 by by IN cord-334315-ymkrgj0h 34 20 inactivating inactivate VBG cord-334315-ymkrgj0h 34 21 or or CC cord-334315-ymkrgj0h 34 22 proteolytically proteolytically RB cord-334315-ymkrgj0h 34 23 degrading degrade VBG cord-334315-ymkrgj0h 34 24 important important JJ cord-334315-ymkrgj0h 34 25 nucleases nuclease NNS cord-334315-ymkrgj0h 34 26 to to TO cord-334315-ymkrgj0h 34 27 promote promote VB cord-334315-ymkrgj0h 34 28 productive productive JJ cord-334315-ymkrgj0h 34 29 viral viral JJ cord-334315-ymkrgj0h 34 30 infections infection NNS cord-334315-ymkrgj0h 34 31 . . . cord-334315-ymkrgj0h 35 1 Paradoxically paradoxically RB cord-334315-ymkrgj0h 35 2 , , , cord-334315-ymkrgj0h 35 3 several several JJ cord-334315-ymkrgj0h 35 4 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 35 5 viruses virus NNS cord-334315-ymkrgj0h 35 6 even even RB cord-334315-ymkrgj0h 35 7 turn turn VBP cord-334315-ymkrgj0h 35 8 a a DT cord-334315-ymkrgj0h 35 9 host host NN cord-334315-ymkrgj0h 35 10 RNA RNA NNP cord-334315-ymkrgj0h 35 11 decay decay NN cord-334315-ymkrgj0h 35 12 factor factor NN cord-334315-ymkrgj0h 35 13 into into IN cord-334315-ymkrgj0h 35 14 a a DT cord-334315-ymkrgj0h 35 15 stabilizing stabilize VBG cord-334315-ymkrgj0h 35 16 factor factor NN cord-334315-ymkrgj0h 35 17 . . . cord-334315-ymkrgj0h 36 1 Several several JJ cord-334315-ymkrgj0h 36 2 viruses virus NNS cord-334315-ymkrgj0h 36 3 have have VBP cord-334315-ymkrgj0h 36 4 developed develop VBN cord-334315-ymkrgj0h 36 5 a a DT cord-334315-ymkrgj0h 36 6 way way NN cord-334315-ymkrgj0h 36 7 to to TO cord-334315-ymkrgj0h 36 8 steal steal VB cord-334315-ymkrgj0h 36 9 the the DT cord-334315-ymkrgj0h 36 10 host host NN cord-334315-ymkrgj0h 36 11 LSm1 LSm1 NNP cord-334315-ymkrgj0h 36 12 - - HYPH cord-334315-ymkrgj0h 36 13 7 7 CD cord-334315-ymkrgj0h 36 14 complex complex NN cord-334315-ymkrgj0h 36 15 that that WDT cord-334315-ymkrgj0h 36 16 normally normally RB cord-334315-ymkrgj0h 36 17 marks mark VBZ cord-334315-ymkrgj0h 36 18 deadenylated deadenylate VBD cord-334315-ymkrgj0h 36 19 transcripts transcript NNS cord-334315-ymkrgj0h 36 20 for for IN cord-334315-ymkrgj0h 36 21 59 59 CD cord-334315-ymkrgj0h 36 22 - - SYM cord-334315-ymkrgj0h 36 23 39 39 CD cord-334315-ymkrgj0h 36 24 degradation degradation NN cord-334315-ymkrgj0h 36 25 . . . cord-334315-ymkrgj0h 37 1 Brome Brome NNP cord-334315-ymkrgj0h 37 2 Mosaic Mosaic NNP cord-334315-ymkrgj0h 37 3 virus virus NN cord-334315-ymkrgj0h 37 4 genomic genomic JJ cord-334315-ymkrgj0h 37 5 RNA RNA NNP cord-334315-ymkrgj0h 37 6 has have VBZ cord-334315-ymkrgj0h 37 7 internal internal JJ cord-334315-ymkrgj0h 37 8 poly(A poly(a JJ cord-334315-ymkrgj0h 37 9 ) ) -RRB- cord-334315-ymkrgj0h 37 10 tracts tract NNS cord-334315-ymkrgj0h 37 11 and and CC cord-334315-ymkrgj0h 37 12 tRNAlike trnalike NN cord-334315-ymkrgj0h 37 13 structures structure NNS cord-334315-ymkrgj0h 37 14 in in IN cord-334315-ymkrgj0h 37 15 the the DT cord-334315-ymkrgj0h 37 16 39 39 CD cord-334315-ymkrgj0h 37 17 UTR UTR NNP cord-334315-ymkrgj0h 37 18 that that WDT cord-334315-ymkrgj0h 37 19 facilitate facilitate VBP cord-334315-ymkrgj0h 37 20 LSm1 LSm1 NNP cord-334315-ymkrgj0h 37 21 - - HYPH cord-334315-ymkrgj0h 37 22 7 7 CD cord-334315-ymkrgj0h 37 23 binding binding NN cord-334315-ymkrgj0h 37 24 to to TO cord-334315-ymkrgj0h 37 25 promote promote VB cord-334315-ymkrgj0h 37 26 viral viral JJ cord-334315-ymkrgj0h 37 27 translation translation NN cord-334315-ymkrgj0h 37 28 and and CC cord-334315-ymkrgj0h 37 29 replication replication NN cord-334315-ymkrgj0h 37 30 [ [ -LRB- cord-334315-ymkrgj0h 37 31 11 11 CD cord-334315-ymkrgj0h 37 32 ] ] -RRB- cord-334315-ymkrgj0h 37 33 . . . cord-334315-ymkrgj0h 38 1 Hepatitis Hepatitis NNP cord-334315-ymkrgj0h 38 2 C C NNP cord-334315-ymkrgj0h 38 3 virus virus NN cord-334315-ymkrgj0h 38 4 ( ( -LRB- cord-334315-ymkrgj0h 38 5 HCV HCV NNP cord-334315-ymkrgj0h 38 6 ) ) -RRB- cord-334315-ymkrgj0h 38 7 RNAs rna NNS cord-334315-ymkrgj0h 38 8 have have VBP cord-334315-ymkrgj0h 38 9 similarly similarly RB cord-334315-ymkrgj0h 38 10 been be VBN cord-334315-ymkrgj0h 38 11 shown show VBN cord-334315-ymkrgj0h 38 12 to to TO cord-334315-ymkrgj0h 38 13 bind bind VB cord-334315-ymkrgj0h 38 14 LSm1 LSm1 NNP cord-334315-ymkrgj0h 38 15 - - HYPH cord-334315-ymkrgj0h 38 16 7 7 CD cord-334315-ymkrgj0h 38 17 , , , cord-334315-ymkrgj0h 38 18 and and CC cord-334315-ymkrgj0h 38 19 knockdown knockdown NN cord-334315-ymkrgj0h 38 20 of of IN cord-334315-ymkrgj0h 38 21 the the DT cord-334315-ymkrgj0h 38 22 RNA RNA NNP cord-334315-ymkrgj0h 38 23 decay decay NN cord-334315-ymkrgj0h 38 24 factors factor NNS cord-334315-ymkrgj0h 38 25 LSm1 lsm1 RBR cord-334315-ymkrgj0h 38 26 and and CC cord-334315-ymkrgj0h 38 27 PatL1 PatL1 NNP cord-334315-ymkrgj0h 38 28 dramatically dramatically RB cord-334315-ymkrgj0h 38 29 reduces reduce VBZ cord-334315-ymkrgj0h 38 30 HCV HCV NNP cord-334315-ymkrgj0h 38 31 translation translation NN cord-334315-ymkrgj0h 38 32 and and CC cord-334315-ymkrgj0h 38 33 replication replication NN cord-334315-ymkrgj0h 38 34 [ [ -LRB- cord-334315-ymkrgj0h 38 35 12 12 CD cord-334315-ymkrgj0h 38 36 ] ] -RRB- cord-334315-ymkrgj0h 38 37 . . . cord-334315-ymkrgj0h 39 1 Finally finally RB cord-334315-ymkrgj0h 39 2 , , , cord-334315-ymkrgj0h 39 3 many many JJ cord-334315-ymkrgj0h 39 4 transcripts transcript NNS cord-334315-ymkrgj0h 39 5 of of IN cord-334315-ymkrgj0h 39 6 the the DT cord-334315-ymkrgj0h 39 7 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 39 8 DNA dna NN cord-334315-ymkrgj0h 39 9 orthopoxviruses orthopoxviruse NNS cord-334315-ymkrgj0h 39 10 have have VBP cord-334315-ymkrgj0h 39 11 unique unique JJ cord-334315-ymkrgj0h 39 12 , , , cord-334315-ymkrgj0h 39 13 nontemplated nontemplate VBN cord-334315-ymkrgj0h 39 14 poly(A poly(A NNP cord-334315-ymkrgj0h 39 15 ) ) -RRB- cord-334315-ymkrgj0h 39 16 tracts tract NNS cord-334315-ymkrgj0h 39 17 at at IN cord-334315-ymkrgj0h 39 18 their -PRON- PRP$ cord-334315-ymkrgj0h 39 19 59 59 CD cord-334315-ymkrgj0h 39 20 ends end NNS cord-334315-ymkrgj0h 39 21 that that WDT cord-334315-ymkrgj0h 39 22 bind bind VBP cord-334315-ymkrgj0h 39 23 LSm1 LSm1 NNP cord-334315-ymkrgj0h 39 24 - - HYPH cord-334315-ymkrgj0h 39 25 7 7 CD cord-334315-ymkrgj0h 39 26 and and CC cord-334315-ymkrgj0h 39 27 can can MD cord-334315-ymkrgj0h 39 28 stabilize stabilize VB cord-334315-ymkrgj0h 39 29 RNAs rna NNS cord-334315-ymkrgj0h 39 30 [ [ -LRB- cord-334315-ymkrgj0h 39 31 13 13 CD cord-334315-ymkrgj0h 39 32 ] ] -RRB- cord-334315-ymkrgj0h 39 33 . . . cord-334315-ymkrgj0h 40 1 Therefore therefore RB cord-334315-ymkrgj0h 40 2 , , , cord-334315-ymkrgj0h 40 3 by by IN cord-334315-ymkrgj0h 40 4 attracting attract VBG cord-334315-ymkrgj0h 40 5 the the DT cord-334315-ymkrgj0h 40 6 LSm1 LSm1 NNP cord-334315-ymkrgj0h 40 7 - - HYPH cord-334315-ymkrgj0h 40 8 7 7 CD cord-334315-ymkrgj0h 40 9 complex complex JJ cord-334315-ymkrgj0h 40 10 and and CC cord-334315-ymkrgj0h 40 11 associated associated JJ cord-334315-ymkrgj0h 40 12 factors factor NNS cord-334315-ymkrgj0h 40 13 in in IN cord-334315-ymkrgj0h 40 14 an an DT cord-334315-ymkrgj0h 40 15 unconventional unconventional JJ cord-334315-ymkrgj0h 40 16 fashion fashion NN cord-334315-ymkrgj0h 40 17 , , , cord-334315-ymkrgj0h 40 18 viral viral JJ cord-334315-ymkrgj0h 40 19 RNAs rna NNS cord-334315-ymkrgj0h 40 20 certainly certainly RB cord-334315-ymkrgj0h 40 21 have have VBP cord-334315-ymkrgj0h 40 22 figured figure VBN cord-334315-ymkrgj0h 40 23 out out RP cord-334315-ymkrgj0h 40 24 a a DT cord-334315-ymkrgj0h 40 25 way way NN cord-334315-ymkrgj0h 40 26 to to TO cord-334315-ymkrgj0h 40 27 make make VB cord-334315-ymkrgj0h 40 28 the the DT cord-334315-ymkrgj0h 40 29 best good JJS cord-334315-ymkrgj0h 40 30 of of IN cord-334315-ymkrgj0h 40 31 what what WP cord-334315-ymkrgj0h 40 32 would would MD cord-334315-ymkrgj0h 40 33 normally normally RB cord-334315-ymkrgj0h 40 34 be be VB cord-334315-ymkrgj0h 40 35 a a DT cord-334315-ymkrgj0h 40 36 bad bad JJ cord-334315-ymkrgj0h 40 37 situation situation NN cord-334315-ymkrgj0h 40 38 for for IN cord-334315-ymkrgj0h 40 39 a a DT cord-334315-ymkrgj0h 40 40 transcript transcript NN cord-334315-ymkrgj0h 40 41 . . . cord-334315-ymkrgj0h 41 1 It -PRON- PRP cord-334315-ymkrgj0h 41 2 has have VBZ cord-334315-ymkrgj0h 41 3 been be VBN cord-334315-ymkrgj0h 41 4 known know VBN cord-334315-ymkrgj0h 41 5 for for IN cord-334315-ymkrgj0h 41 6 some some DT cord-334315-ymkrgj0h 41 7 time time NN cord-334315-ymkrgj0h 41 8 that that WDT cord-334315-ymkrgj0h 41 9 members member NNS cord-334315-ymkrgj0h 41 10 of of IN cord-334315-ymkrgj0h 41 11 the the DT cord-334315-ymkrgj0h 41 12 Arenaviridae Arenaviridae NNP cord-334315-ymkrgj0h 41 13 , , , cord-334315-ymkrgj0h 41 14 Bunyaviridae Bunyaviridae NNP cord-334315-ymkrgj0h 41 15 , , , cord-334315-ymkrgj0h 41 16 and and CC cord-334315-ymkrgj0h 41 17 the the DT cord-334315-ymkrgj0h 41 18 nuclear nuclear JJ cord-334315-ymkrgj0h 41 19 Orthomyxoviridae Orthomyxoviridae NNP cord-334315-ymkrgj0h 41 20 families family NNS cord-334315-ymkrgj0h 41 21 steal steal VBP cord-334315-ymkrgj0h 41 22 the the DT cord-334315-ymkrgj0h 41 23 59 59 CD cord-334315-ymkrgj0h 41 24 capped cap VBN cord-334315-ymkrgj0h 41 25 ends end NNS cord-334315-ymkrgj0h 41 26 of of IN cord-334315-ymkrgj0h 41 27 host host NN cord-334315-ymkrgj0h 41 28 mRNAs mRNAs '' cord-334315-ymkrgj0h 41 29 to to TO cord-334315-ymkrgj0h 41 30 incorporate incorporate VB cord-334315-ymkrgj0h 41 31 this this DT cord-334315-ymkrgj0h 41 32 cisacting cisacte VBG cord-334315-ymkrgj0h 41 33 stability stability NN cord-334315-ymkrgj0h 41 34 element element NN cord-334315-ymkrgj0h 41 35 into into IN cord-334315-ymkrgj0h 41 36 their -PRON- PRP$ cord-334315-ymkrgj0h 41 37 own own JJ cord-334315-ymkrgj0h 41 38 transcripts transcript NNS cord-334315-ymkrgj0h 41 39 [ [ -LRB- cord-334315-ymkrgj0h 41 40 14 14 CD cord-334315-ymkrgj0h 41 41 ] ] -RRB- cord-334315-ymkrgj0h 41 42 . . . cord-334315-ymkrgj0h 42 1 Emerging emerge VBG cord-334315-ymkrgj0h 42 2 evidence evidence NN cord-334315-ymkrgj0h 42 3 indicates indicate VBZ cord-334315-ymkrgj0h 42 4 that that IN cord-334315-ymkrgj0h 42 5 the the DT cord-334315-ymkrgj0h 42 6 29-O 29-o CD cord-334315-ymkrgj0h 42 7 - - HYPH cord-334315-ymkrgj0h 42 8 methylation methylation NN cord-334315-ymkrgj0h 42 9 of of IN cord-334315-ymkrgj0h 42 10 cap cap NN cord-334315-ymkrgj0h 42 11 structures structure NNS cord-334315-ymkrgj0h 42 12 is be VBZ cord-334315-ymkrgj0h 42 13 read read VBN cord-334315-ymkrgj0h 42 14 by by IN cord-334315-ymkrgj0h 42 15 innate innate JJ cord-334315-ymkrgj0h 42 16 immune immune JJ cord-334315-ymkrgj0h 42 17 interferon interferon NN cord-334315-ymkrgj0h 42 18 stimulated stimulate VBD cord-334315-ymkrgj0h 42 19 genes gene NNS cord-334315-ymkrgj0h 42 20 ( ( -LRB- cord-334315-ymkrgj0h 42 21 ISGs ISGs NNP cord-334315-ymkrgj0h 42 22 ) ) -RRB- cord-334315-ymkrgj0h 42 23 as as IN cord-334315-ymkrgj0h 42 24 a a DT cord-334315-ymkrgj0h 42 25 way way NN cord-334315-ymkrgj0h 42 26 to to TO cord-334315-ymkrgj0h 42 27 differentiate differentiate VB cord-334315-ymkrgj0h 42 28 host host NN cord-334315-ymkrgj0h 42 29 versus versus IN cord-334315-ymkrgj0h 42 30 virus virus NN cord-334315-ymkrgj0h 42 31 transcripts transcript NNS cord-334315-ymkrgj0h 42 32 . . . cord-334315-ymkrgj0h 43 1 Cap cap NN cord-334315-ymkrgj0h 43 2 - - HYPH cord-334315-ymkrgj0h 43 3 stealing steal VBG cord-334315-ymkrgj0h 43 4 mechanisms mechanism NNS cord-334315-ymkrgj0h 43 5 used use VBN cord-334315-ymkrgj0h 43 6 by by IN cord-334315-ymkrgj0h 43 7 segmented segmented JJ cord-334315-ymkrgj0h 43 8 RNA RNA NNP cord-334315-ymkrgj0h 43 9 viruses virus NNS cord-334315-ymkrgj0h 43 10 to to TO cord-334315-ymkrgj0h 43 11 generate generate VB cord-334315-ymkrgj0h 43 12 their -PRON- PRP$ cord-334315-ymkrgj0h 43 13 mRNAs mrnas TO cord-334315-ymkrgj0h 43 14 circumvent circumvent VB cord-334315-ymkrgj0h 43 15 this this DT cord-334315-ymkrgj0h 43 16 innate innate JJ cord-334315-ymkrgj0h 43 17 detection detection NN cord-334315-ymkrgj0h 43 18 system system NN cord-334315-ymkrgj0h 43 19 . . . cord-334315-ymkrgj0h 44 1 Furthermore furthermore RB cord-334315-ymkrgj0h 44 2 , , , cord-334315-ymkrgj0h 44 3 recent recent JJ cord-334315-ymkrgj0h 44 4 evidence evidence NN cord-334315-ymkrgj0h 44 5 indicates indicate VBZ cord-334315-ymkrgj0h 44 6 that that IN cord-334315-ymkrgj0h 44 7 cellular cellular JJ cord-334315-ymkrgj0h 44 8 trans trans JJ cord-334315-ymkrgj0h 44 9 - - JJ cord-334315-ymkrgj0h 44 10 acting acting JJ cord-334315-ymkrgj0h 44 11 factors factor NNS cord-334315-ymkrgj0h 44 12 that that WDT cord-334315-ymkrgj0h 44 13 stabilize stabilize VBP cord-334315-ymkrgj0h 44 14 host host NN cord-334315-ymkrgj0h 44 15 transcripts transcript NNS cord-334315-ymkrgj0h 44 16 are be VBP cord-334315-ymkrgj0h 44 17 also also RB cord-334315-ymkrgj0h 44 18 purloined purloin VBN cord-334315-ymkrgj0h 44 19 by by IN cord-334315-ymkrgj0h 44 20 thieving thieve VBG cord-334315-ymkrgj0h 44 21 viral viral JJ cord-334315-ymkrgj0h 44 22 RNAs rna NNS cord-334315-ymkrgj0h 44 23 . . . cord-334315-ymkrgj0h 45 1 The the DT cord-334315-ymkrgj0h 45 2 cellular cellular JJ cord-334315-ymkrgj0h 45 3 HuR hur NN cord-334315-ymkrgj0h 45 4 protein protein NN cord-334315-ymkrgj0h 45 5 is be VBZ cord-334315-ymkrgj0h 45 6 a a DT cord-334315-ymkrgj0h 45 7 well well RB cord-334315-ymkrgj0h 45 8 - - HYPH cord-334315-ymkrgj0h 45 9 characterized characterize VBN cord-334315-ymkrgj0h 45 10 shuttling shuttle VBG cord-334315-ymkrgj0h 45 11 factor factor NN cord-334315-ymkrgj0h 45 12 that that WDT cord-334315-ymkrgj0h 45 13 promotes promote VBZ cord-334315-ymkrgj0h 45 14 the the DT cord-334315-ymkrgj0h 45 15 stability stability NN cord-334315-ymkrgj0h 45 16 of of IN cord-334315-ymkrgj0h 45 17 mRNAs mRNAs NNPS cord-334315-ymkrgj0h 45 18 by by IN cord-334315-ymkrgj0h 45 19 interacting interact VBG cord-334315-ymkrgj0h 45 20 with with IN cord-334315-ymkrgj0h 45 21 U u JJ cord-334315-ymkrgj0h 45 22 - - JJ cord-334315-ymkrgj0h 45 23 rich rich JJ cord-334315-ymkrgj0h 45 24 elements element NNS cord-334315-ymkrgj0h 45 25 . . . cord-334315-ymkrgj0h 46 1 Alphaviruses alphavirus NNS cord-334315-ymkrgj0h 46 2 contain contain VBP cord-334315-ymkrgj0h 46 3 highly highly RB cord-334315-ymkrgj0h 46 4 conserved conserve VBN cord-334315-ymkrgj0h 46 5 U u NN cord-334315-ymkrgj0h 46 6 - - HYPH cord-334315-ymkrgj0h 46 7 rich rich JJ cord-334315-ymkrgj0h 46 8 elements element NNS cord-334315-ymkrgj0h 46 9 or or CC cord-334315-ymkrgj0h 46 10 other other JJ cord-334315-ymkrgj0h 46 11 high high JJ cord-334315-ymkrgj0h 46 12 - - HYPH cord-334315-ymkrgj0h 46 13 affinity affinity NN cord-334315-ymkrgj0h 46 14 HuR hur NN cord-334315-ymkrgj0h 46 15 binding bind VBG cord-334315-ymkrgj0h 46 16 sites site NNS cord-334315-ymkrgj0h 46 17 in in IN cord-334315-ymkrgj0h 46 18 the the DT cord-334315-ymkrgj0h 46 19 39 39 CD cord-334315-ymkrgj0h 46 20 UTR UTR NNP cord-334315-ymkrgj0h 46 21 of of IN cord-334315-ymkrgj0h 46 22 their -PRON- PRP$ cord-334315-ymkrgj0h 46 23 RNAs rna NNS cord-334315-ymkrgj0h 46 24 that that WDT cord-334315-ymkrgj0h 46 25 bind bind VBP cord-334315-ymkrgj0h 46 26 HuR hur NN cord-334315-ymkrgj0h 46 27 during during IN cord-334315-ymkrgj0h 46 28 infection infection NN cord-334315-ymkrgj0h 46 29 to to TO cord-334315-ymkrgj0h 46 30 promote promote VB cord-334315-ymkrgj0h 46 31 viral viral JJ cord-334315-ymkrgj0h 46 32 RNA rna NN cord-334315-ymkrgj0h 46 33 stability stability NN cord-334315-ymkrgj0h 46 34 and and CC cord-334315-ymkrgj0h 46 35 efficient efficient JJ cord-334315-ymkrgj0h 46 36 virus virus NN cord-334315-ymkrgj0h 46 37 production production NN cord-334315-ymkrgj0h 46 38 [ [ -LRB- cord-334315-ymkrgj0h 46 39 15 15 CD cord-334315-ymkrgj0h 46 40 , , , cord-334315-ymkrgj0h 46 41 16 16 CD cord-334315-ymkrgj0h 46 42 ] ] -RRB- cord-334315-ymkrgj0h 46 43 . . . cord-334315-ymkrgj0h 47 1 HuR HuR NNP cord-334315-ymkrgj0h 47 2 is be VBZ cord-334315-ymkrgj0h 47 3 not not RB cord-334315-ymkrgj0h 47 4 the the DT cord-334315-ymkrgj0h 47 5 only only JJ cord-334315-ymkrgj0h 47 6 regulatory regulatory JJ cord-334315-ymkrgj0h 47 7 mRNA mrna NN cord-334315-ymkrgj0h 47 8 decay decay NN cord-334315-ymkrgj0h 47 9 factor factor NN cord-334315-ymkrgj0h 47 10 that that WDT cord-334315-ymkrgj0h 47 11 is be VBZ cord-334315-ymkrgj0h 47 12 commandeered commandeer VBN cord-334315-ymkrgj0h 47 13 by by IN cord-334315-ymkrgj0h 47 14 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 47 15 RNA RNA NNP cord-334315-ymkrgj0h 47 16 viruses virus NNS cord-334315-ymkrgj0h 47 17 . . . cord-334315-ymkrgj0h 48 1 Rabies rabies NN cord-334315-ymkrgj0h 48 2 virus virus NN cord-334315-ymkrgj0h 48 3 glycoprotein glycoprotein NN cord-334315-ymkrgj0h 48 4 mRNA mrna NN cord-334315-ymkrgj0h 48 5 and and CC cord-334315-ymkrgj0h 48 6 poliovirus poliovirus NN cord-334315-ymkrgj0h 48 7 transcripts transcript NNS cord-334315-ymkrgj0h 48 8 steal steal VBP cord-334315-ymkrgj0h 48 9 host host NN cord-334315-ymkrgj0h 48 10 poly(C poly(c CD cord-334315-ymkrgj0h 48 11 ) ) -RRB- cord-334315-ymkrgj0h 49 1 binding bind VBG cord-334315-ymkrgj0h 49 2 protein protein NN cord-334315-ymkrgj0h 49 3 2 2 CD cord-334315-ymkrgj0h 49 4 ( ( -LRB- cord-334315-ymkrgj0h 49 5 PCBP2 PCBP2 NNP cord-334315-ymkrgj0h 49 6 ) ) -RRB- cord-334315-ymkrgj0h 49 7 , , , cord-334315-ymkrgj0h 49 8 leading lead VBG cord-334315-ymkrgj0h 49 9 to to IN cord-334315-ymkrgj0h 49 10 increased increase VBN cord-334315-ymkrgj0h 49 11 transcript transcript NN cord-334315-ymkrgj0h 49 12 abundance abundance NN cord-334315-ymkrgj0h 49 13 and and CC cord-334315-ymkrgj0h 49 14 stability stability NN cord-334315-ymkrgj0h 49 15 [ [ -LRB- cord-334315-ymkrgj0h 49 16 17 17 CD cord-334315-ymkrgj0h 49 17 , , , cord-334315-ymkrgj0h 49 18 18 18 CD cord-334315-ymkrgj0h 49 19 ] ] -RRB- cord-334315-ymkrgj0h 49 20 . . . cord-334315-ymkrgj0h 50 1 Usurping usurping JJ cord-334315-ymkrgj0h 50 2 PCBP2 PCBP2 NNP cord-334315-ymkrgj0h 50 3 may may MD cord-334315-ymkrgj0h 50 4 help help VB cord-334315-ymkrgj0h 50 5 rabies rabies VB cord-334315-ymkrgj0h 50 6 virus virus NN cord-334315-ymkrgj0h 50 7 tightly tightly RB cord-334315-ymkrgj0h 50 8 regulate regulate VBP cord-334315-ymkrgj0h 50 9 expression expression NN cord-334315-ymkrgj0h 50 10 of of IN cord-334315-ymkrgj0h 50 11 its -PRON- PRP$ cord-334315-ymkrgj0h 50 12 glycoprotein glycoprotein NN cord-334315-ymkrgj0h 50 13 to to TO cord-334315-ymkrgj0h 50 14 avoid avoid VB cord-334315-ymkrgj0h 50 15 host host NN cord-334315-ymkrgj0h 50 16 immune immune JJ cord-334315-ymkrgj0h 50 17 detection detection NN cord-334315-ymkrgj0h 50 18 as as IN cord-334315-ymkrgj0h 50 19 it -PRON- PRP cord-334315-ymkrgj0h 50 20 replicates replicate VBZ cord-334315-ymkrgj0h 50 21 and and CC cord-334315-ymkrgj0h 50 22 migrates migrate VBZ cord-334315-ymkrgj0h 50 23 to to IN cord-334315-ymkrgj0h 50 24 the the DT cord-334315-ymkrgj0h 50 25 central central JJ cord-334315-ymkrgj0h 50 26 nervous nervous JJ cord-334315-ymkrgj0h 50 27 system system NN cord-334315-ymkrgj0h 50 28 during during IN cord-334315-ymkrgj0h 50 29 infection infection NN cord-334315-ymkrgj0h 50 30 . . . cord-334315-ymkrgj0h 51 1 Viral viral JJ cord-334315-ymkrgj0h 51 2 RNAs rna NNS cord-334315-ymkrgj0h 51 3 may may MD cord-334315-ymkrgj0h 51 4 also also RB cord-334315-ymkrgj0h 51 5 ' ' '' cord-334315-ymkrgj0h 51 6 ' ' `` cord-334315-ymkrgj0h 51 7 sponge sponge NN cord-334315-ymkrgj0h 51 8 ' ' '' cord-334315-ymkrgj0h 51 9 ' ' '' cord-334315-ymkrgj0h 51 10 miRNAs miRNAs NNP cord-334315-ymkrgj0h 51 11 ( ( -LRB- cord-334315-ymkrgj0h 51 12 e.g. e.g. RB cord-334315-ymkrgj0h 51 13 [ [ -LRB- cord-334315-ymkrgj0h 51 14 19 19 CD cord-334315-ymkrgj0h 51 15 ] ] -RRB- cord-334315-ymkrgj0h 51 16 ) ) -RRB- cord-334315-ymkrgj0h 52 1 and and CC cord-334315-ymkrgj0h 52 2 , , , cord-334315-ymkrgj0h 52 3 perhaps perhaps RB cord-334315-ymkrgj0h 52 4 , , , cord-334315-ymkrgj0h 52 5 cellular cellular JJ cord-334315-ymkrgj0h 52 6 RNA RNA NNP cord-334315-ymkrgj0h 52 7 binding bind VBG cord-334315-ymkrgj0h 52 8 proteins protein NNS cord-334315-ymkrgj0h 52 9 by by IN cord-334315-ymkrgj0h 52 10 sequestering sequester VBG cord-334315-ymkrgj0h 52 11 these these DT cord-334315-ymkrgj0h 52 12 cellular cellular JJ cord-334315-ymkrgj0h 52 13 factors factor NNS cord-334315-ymkrgj0h 52 14 on on IN cord-334315-ymkrgj0h 52 15 high high JJ cord-334315-ymkrgj0h 52 16 affinity affinity NN cord-334315-ymkrgj0h 52 17 binding bind VBG cord-334315-ymkrgj0h 52 18 sites site NNS cord-334315-ymkrgj0h 52 19 present present JJ cord-334315-ymkrgj0h 52 20 on on IN cord-334315-ymkrgj0h 52 21 viral viral JJ cord-334315-ymkrgj0h 52 22 transcripts transcript NNS cord-334315-ymkrgj0h 52 23 to to TO cord-334315-ymkrgj0h 52 24 promote promote VB cord-334315-ymkrgj0h 52 25 viral viral JJ cord-334315-ymkrgj0h 52 26 - - HYPH cord-334315-ymkrgj0h 52 27 specific specific JJ cord-334315-ymkrgj0h 52 28 gene gene NN cord-334315-ymkrgj0h 52 29 expression expression NN cord-334315-ymkrgj0h 52 30 . . . cord-334315-ymkrgj0h 53 1 Viral Viral NNP cord-334315-ymkrgj0h 53 2 - - HYPH cord-334315-ymkrgj0h 53 3 Encoded encode VBN cord-334315-ymkrgj0h 53 4 Ribonucleases ribonuclease NNS cord-334315-ymkrgj0h 54 1 : : : cord-334315-ymkrgj0h 54 2 If if IN cord-334315-ymkrgj0h 54 3 You -PRON- PRP cord-334315-ymkrgj0h 54 4 Do do VBP cord-334315-ymkrgj0h 54 5 n't not RB cord-334315-ymkrgj0h 54 6 Like like VB cord-334315-ymkrgj0h 54 7 the the DT cord-334315-ymkrgj0h 54 8 Sandbox sandbox NN cord-334315-ymkrgj0h 54 9 That that WDT cord-334315-ymkrgj0h 54 10 You -PRON- PRP cord-334315-ymkrgj0h 54 11 Are be VBP cord-334315-ymkrgj0h 54 12 Playing play VBG cord-334315-ymkrgj0h 54 13 in in RP cord-334315-ymkrgj0h 54 14 , , , cord-334315-ymkrgj0h 54 15 Make make VB cord-334315-ymkrgj0h 54 16 a a DT cord-334315-ymkrgj0h 54 17 New New NNP cord-334315-ymkrgj0h 54 18 One One NNP cord-334315-ymkrgj0h 54 19 Virally virally RB cord-334315-ymkrgj0h 54 20 encoded encode VBN cord-334315-ymkrgj0h 54 21 endonucleases endonuclease NNS cord-334315-ymkrgj0h 54 22 are be VBP cord-334315-ymkrgj0h 54 23 important important JJ cord-334315-ymkrgj0h 54 24 for for IN cord-334315-ymkrgj0h 54 25 many many JJ cord-334315-ymkrgj0h 54 26 aspects aspect NNS cord-334315-ymkrgj0h 54 27 of of IN cord-334315-ymkrgj0h 54 28 viral viral JJ cord-334315-ymkrgj0h 54 29 replication replication NN cord-334315-ymkrgj0h 54 30 , , , cord-334315-ymkrgj0h 54 31 including include VBG cord-334315-ymkrgj0h 54 32 the the DT cord-334315-ymkrgj0h 54 33 fine fine JJ cord-334315-ymkrgj0h 54 34 - - HYPH cord-334315-ymkrgj0h 54 35 tuning tuning NN cord-334315-ymkrgj0h 54 36 of of IN cord-334315-ymkrgj0h 54 37 viral viral JJ cord-334315-ymkrgj0h 54 38 gene gene NN cord-334315-ymkrgj0h 54 39 expression expression NN cord-334315-ymkrgj0h 54 40 by by IN cord-334315-ymkrgj0h 54 41 rapidly rapidly RB cord-334315-ymkrgj0h 54 42 depleting deplete VBG cord-334315-ymkrgj0h 54 43 old old JJ cord-334315-ymkrgj0h 54 44 viral viral NN cord-334315-ymkrgj0h 54 45 mRNAs mrnas $ cord-334315-ymkrgj0h 54 46 to to TO cord-334315-ymkrgj0h 54 47 enhance enhance VB cord-334315-ymkrgj0h 54 48 the the DT cord-334315-ymkrgj0h 54 49 expression expression NN cord-334315-ymkrgj0h 54 50 of of IN cord-334315-ymkrgj0h 54 51 newly newly RB cord-334315-ymkrgj0h 54 52 transcribed transcribe VBN cord-334315-ymkrgj0h 54 53 mRNAs mrnas XX cord-334315-ymkrgj0h 54 54 [ [ -LRB- cord-334315-ymkrgj0h 54 55 20 20 CD cord-334315-ymkrgj0h 54 56 ] ] -RRB- cord-334315-ymkrgj0h 54 57 . . . cord-334315-ymkrgj0h 55 1 In in IN cord-334315-ymkrgj0h 55 2 addition addition NN cord-334315-ymkrgj0h 55 3 , , , cord-334315-ymkrgj0h 55 4 to to TO cord-334315-ymkrgj0h 55 5 make make VB cord-334315-ymkrgj0h 55 6 a a DT cord-334315-ymkrgj0h 55 7 cell cell NN cord-334315-ymkrgj0h 55 8 more more RBR cord-334315-ymkrgj0h 55 9 amenable amenable JJ cord-334315-ymkrgj0h 55 10 to to IN cord-334315-ymkrgj0h 55 11 virus virus NN cord-334315-ymkrgj0h 55 12 production production NN cord-334315-ymkrgj0h 55 13 , , , cord-334315-ymkrgj0h 55 14 these these DT cord-334315-ymkrgj0h 55 15 virally virally RB cord-334315-ymkrgj0h 55 16 encoded encode VBN cord-334315-ymkrgj0h 55 17 nucleases nuclease NNS cord-334315-ymkrgj0h 55 18 may may MD cord-334315-ymkrgj0h 55 19 also also RB cord-334315-ymkrgj0h 55 20 create create VB cord-334315-ymkrgj0h 55 21 a a DT cord-334315-ymkrgj0h 55 22 new new JJ cord-334315-ymkrgj0h 55 23 ' ' '' cord-334315-ymkrgj0h 55 24 ' ' `` cord-334315-ymkrgj0h 55 25 sandbox sandbox NN cord-334315-ymkrgj0h 55 26 ' ' '' cord-334315-ymkrgj0h 55 27 ' ' '' cord-334315-ymkrgj0h 55 28 in in IN cord-334315-ymkrgj0h 55 29 the the DT cord-334315-ymkrgj0h 55 30 cytoplasm cytoplasm NN cord-334315-ymkrgj0h 55 31 for for IN cord-334315-ymkrgj0h 55 32 viral viral JJ cord-334315-ymkrgj0h 55 33 RNAs rna NNS cord-334315-ymkrgj0h 55 34 by by IN cord-334315-ymkrgj0h 55 35 initiating initiate VBG cord-334315-ymkrgj0h 55 36 the the DT cord-334315-ymkrgj0h 55 37 large large JJ cord-334315-ymkrgj0h 55 38 - - HYPH cord-334315-ymkrgj0h 55 39 scale scale NN cord-334315-ymkrgj0h 55 40 decay decay NN cord-334315-ymkrgj0h 55 41 of of IN cord-334315-ymkrgj0h 55 42 cellular cellular NN cord-334315-ymkrgj0h 55 43 mRNAs mrna NNS cord-334315-ymkrgj0h 55 44 and and CC cord-334315-ymkrgj0h 55 45 dramatically dramatically RB cord-334315-ymkrgj0h 55 46 altering alter VBG cord-334315-ymkrgj0h 55 47 the the DT cord-334315-ymkrgj0h 55 48 landscape landscape NN cord-334315-ymkrgj0h 55 49 of of IN cord-334315-ymkrgj0h 55 50 host host NN cord-334315-ymkrgj0h 55 51 gene gene NN cord-334315-ymkrgj0h 55 52 expression expression NN cord-334315-ymkrgj0h 55 53 . . . cord-334315-ymkrgj0h 56 1 Interestingly interestingly RB cord-334315-ymkrgj0h 56 2 , , , cord-334315-ymkrgj0h 56 3 the the DT cord-334315-ymkrgj0h 56 4 internal internal JJ cord-334315-ymkrgj0h 56 5 cleavage cleavage NN cord-334315-ymkrgj0h 56 6 of of IN cord-334315-ymkrgj0h 56 7 host host NN cord-334315-ymkrgj0h 56 8 mRNAs mrna NNS cord-334315-ymkrgj0h 56 9 by by IN cord-334315-ymkrgj0h 56 10 disparate disparate JJ cord-334315-ymkrgj0h 56 11 betacoronaviruses betacoronaviruse NNS cord-334315-ymkrgj0h 56 12 , , , cord-334315-ymkrgj0h 56 13 influenza influenza NN cord-334315-ymkrgj0h 56 14 viruses virus NNS cord-334315-ymkrgj0h 56 15 , , , cord-334315-ymkrgj0h 56 16 vaccinia vaccinia NN cord-334315-ymkrgj0h 56 17 viruses virus NNS cord-334315-ymkrgj0h 56 18 , , , cord-334315-ymkrgj0h 56 19 and and CC cord-334315-ymkrgj0h 56 20 the the DT cord-334315-ymkrgj0h 56 21 nuclear nuclear JJ cord-334315-ymkrgj0h 56 22 herpesviruses herpesviruse NNS cord-334315-ymkrgj0h 56 23 may may MD cord-334315-ymkrgj0h 56 24 force force VB cord-334315-ymkrgj0h 56 25 host host NN cord-334315-ymkrgj0h 56 26 exoribonucleases exoribonuclease NNS cord-334315-ymkrgj0h 56 27 like like IN cord-334315-ymkrgj0h 56 28 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 56 29 and and CC cord-334315-ymkrgj0h 56 30 the the DT cord-334315-ymkrgj0h 56 31 exosome exosome NN cord-334315-ymkrgj0h 56 32 to to TO cord-334315-ymkrgj0h 56 33 divert divert VB cord-334315-ymkrgj0h 56 34 their -PRON- PRP$ cord-334315-ymkrgj0h 56 35 attention attention NN cord-334315-ymkrgj0h 56 36 to to IN cord-334315-ymkrgj0h 56 37 degrading degrade VBG cord-334315-ymkrgj0h 56 38 this this DT cord-334315-ymkrgj0h 56 39 large large JJ cord-334315-ymkrgj0h 56 40 number number NN cord-334315-ymkrgj0h 56 41 of of IN cord-334315-ymkrgj0h 56 42 products product NNS cord-334315-ymkrgj0h 56 43 of of IN cord-334315-ymkrgj0h 56 44 viral viral JJ cord-334315-ymkrgj0h 56 45 endonucleolytic endonucleolytic JJ cord-334315-ymkrgj0h 56 46 decay decay NN cord-334315-ymkrgj0h 56 47 [ [ -LRB- cord-334315-ymkrgj0h 56 48 21 21 CD cord-334315-ymkrgj0h 56 49 ] ] -RRB- cord-334315-ymkrgj0h 56 50 . . . cord-334315-ymkrgj0h 57 1 The the DT cord-334315-ymkrgj0h 57 2 host host NN cord-334315-ymkrgj0h 57 3 RNA RNA NNP cord-334315-ymkrgj0h 57 4 decay decay NN cord-334315-ymkrgj0h 57 5 machinery machinery NN cord-334315-ymkrgj0h 57 6 may may MD cord-334315-ymkrgj0h 57 7 , , , cord-334315-ymkrgj0h 57 8 therefore therefore RB cord-334315-ymkrgj0h 57 9 , , , cord-334315-ymkrgj0h 57 10 become become VBP cord-334315-ymkrgj0h 57 11 saturated saturated JJ cord-334315-ymkrgj0h 57 12 as as IN cord-334315-ymkrgj0h 57 13 endonucleolytic endonucleolytic JJ cord-334315-ymkrgj0h 57 14 decay decay NN cord-334315-ymkrgj0h 57 15 products product NNS cord-334315-ymkrgj0h 57 16 rapidly rapidly RB cord-334315-ymkrgj0h 57 17 accumulate accumulate VBP cord-334315-ymkrgj0h 57 18 during during IN cord-334315-ymkrgj0h 57 19 viral viral JJ cord-334315-ymkrgj0h 57 20 infection infection NN cord-334315-ymkrgj0h 57 21 , , , cord-334315-ymkrgj0h 57 22 limiting limit VBG cord-334315-ymkrgj0h 57 23 its -PRON- PRP$ cord-334315-ymkrgj0h 57 24 normal normal JJ cord-334315-ymkrgj0h 57 25 functions function NNS cord-334315-ymkrgj0h 57 26 . . . cord-334315-ymkrgj0h 58 1 Thus thus RB cord-334315-ymkrgj0h 58 2 , , , cord-334315-ymkrgj0h 58 3 virus virus NN cord-334315-ymkrgj0h 58 4 - - HYPH cord-334315-ymkrgj0h 58 5 derived derive VBN cord-334315-ymkrgj0h 58 6 nucleases nuclease NNS cord-334315-ymkrgj0h 58 7 may may MD cord-334315-ymkrgj0h 58 8 disrupt disrupt VB cord-334315-ymkrgj0h 58 9 normal normal JJ cord-334315-ymkrgj0h 58 10 gene gene NN cord-334315-ymkrgj0h 58 11 expression expression NN cord-334315-ymkrgj0h 58 12 and and CC cord-334315-ymkrgj0h 58 13 RNA RNA NNP cord-334315-ymkrgj0h 58 14 decayrelated decayrelate VBD cord-334315-ymkrgj0h 58 15 quality quality NN cord-334315-ymkrgj0h 58 16 control control NN cord-334315-ymkrgj0h 58 17 mechanisms mechanism NNS cord-334315-ymkrgj0h 58 18 to to TO cord-334315-ymkrgj0h 58 19 help help VB cord-334315-ymkrgj0h 58 20 viral viral JJ cord-334315-ymkrgj0h 58 21 RNAs rna NNS cord-334315-ymkrgj0h 58 22 escape escape VB cord-334315-ymkrgj0h 58 23 detection detection NN cord-334315-ymkrgj0h 58 24 by by IN cord-334315-ymkrgj0h 58 25 the the DT cord-334315-ymkrgj0h 58 26 cellular cellular JJ cord-334315-ymkrgj0h 58 27 RNA RNA NNP cord-334315-ymkrgj0h 58 28 decay decay NN cord-334315-ymkrgj0h 58 29 machinery machinery NN cord-334315-ymkrgj0h 58 30 . . . cord-334315-ymkrgj0h 59 1 Considering consider VBG cord-334315-ymkrgj0h 59 2 the the DT cord-334315-ymkrgj0h 59 3 importance importance NN cord-334315-ymkrgj0h 59 4 of of IN cord-334315-ymkrgj0h 59 5 RNA RNA NNP cord-334315-ymkrgj0h 59 6 stability stability NN cord-334315-ymkrgj0h 59 7 in in IN cord-334315-ymkrgj0h 59 8 regulating regulate VBG cord-334315-ymkrgj0h 59 9 transcript transcript NN cord-334315-ymkrgj0h 59 10 abundance abundance NN cord-334315-ymkrgj0h 59 11 , , , cord-334315-ymkrgj0h 59 12 the the DT cord-334315-ymkrgj0h 59 13 inactivation inactivation NN cord-334315-ymkrgj0h 59 14 or or CC cord-334315-ymkrgj0h 59 15 commandeering commandeering NN cord-334315-ymkrgj0h 59 16 of of IN cord-334315-ymkrgj0h 59 17 cellular cellular JJ cord-334315-ymkrgj0h 59 18 RNA RNA NNP cord-334315-ymkrgj0h 59 19 decay decay NN cord-334315-ymkrgj0h 59 20 factors factor NNS cord-334315-ymkrgj0h 59 21 by by IN cord-334315-ymkrgj0h 59 22 viruses virus NNS cord-334315-ymkrgj0h 59 23 is be VBZ cord-334315-ymkrgj0h 59 24 likely likely JJ cord-334315-ymkrgj0h 59 25 to to TO cord-334315-ymkrgj0h 59 26 significantly significantly RB cord-334315-ymkrgj0h 59 27 alter alter VB cord-334315-ymkrgj0h 59 28 host host NN cord-334315-ymkrgj0h 59 29 gene gene NN cord-334315-ymkrgj0h 59 30 expression expression NN cord-334315-ymkrgj0h 59 31 . . . cord-334315-ymkrgj0h 60 1 How how WRB cord-334315-ymkrgj0h 60 2 might may MD cord-334315-ymkrgj0h 60 3 changes change NNS cord-334315-ymkrgj0h 60 4 in in IN cord-334315-ymkrgj0h 60 5 host host NN cord-334315-ymkrgj0h 60 6 mRNA mrna NN cord-334315-ymkrgj0h 60 7 stability stability NN cord-334315-ymkrgj0h 60 8 contribute contribute VBP cord-334315-ymkrgj0h 60 9 to to IN cord-334315-ymkrgj0h 60 10 virus virus NN cord-334315-ymkrgj0h 60 11 - - HYPH cord-334315-ymkrgj0h 60 12 induced induce VBN cord-334315-ymkrgj0h 60 13 pathology pathology NN cord-334315-ymkrgj0h 60 14 during during IN cord-334315-ymkrgj0h 60 15 infection infection NN cord-334315-ymkrgj0h 60 16 ( ( -LRB- cord-334315-ymkrgj0h 60 17 Figure figure NN cord-334315-ymkrgj0h 60 18 1 1 CD cord-334315-ymkrgj0h 60 19 ) ) -RRB- cord-334315-ymkrgj0h 60 20 ? ? . cord-334315-ymkrgj0h 61 1 One one CD cord-334315-ymkrgj0h 61 2 example example NN cord-334315-ymkrgj0h 61 3 of of IN cord-334315-ymkrgj0h 61 4 this this DT cord-334315-ymkrgj0h 61 5 phenomenon phenomenon NN cord-334315-ymkrgj0h 61 6 is be VBZ cord-334315-ymkrgj0h 61 7 that that IN cord-334315-ymkrgj0h 61 8 wild wild JJ cord-334315-ymkrgj0h 61 9 - - HYPH cord-334315-ymkrgj0h 61 10 type type NN cord-334315-ymkrgj0h 61 11 Kunjin Kunjin NNP cord-334315-ymkrgj0h 61 12 virus virus NN cord-334315-ymkrgj0h 61 13 was be VBD cord-334315-ymkrgj0h 61 14 significantly significantly RB cord-334315-ymkrgj0h 61 15 more more RBR cord-334315-ymkrgj0h 61 16 pathogenic pathogenic JJ cord-334315-ymkrgj0h 61 17 in in IN cord-334315-ymkrgj0h 61 18 both both DT cord-334315-ymkrgj0h 61 19 tissue tissue NN cord-334315-ymkrgj0h 61 20 culture culture NN cord-334315-ymkrgj0h 61 21 and and CC cord-334315-ymkrgj0h 61 22 mouse mouse NN cord-334315-ymkrgj0h 61 23 models model NNS cord-334315-ymkrgj0h 61 24 of of IN cord-334315-ymkrgj0h 61 25 infection infection NN cord-334315-ymkrgj0h 61 26 than than IN cord-334315-ymkrgj0h 61 27 a a DT cord-334315-ymkrgj0h 61 28 mutant mutant JJ cord-334315-ymkrgj0h 61 29 virus virus NN cord-334315-ymkrgj0h 61 30 incapable incapable JJ cord-334315-ymkrgj0h 61 31 of of IN cord-334315-ymkrgj0h 61 32 forming form VBG cord-334315-ymkrgj0h 61 33 sfRNA sfRNA NNS cord-334315-ymkrgj0h 61 34 [ [ -LRB- cord-334315-ymkrgj0h 61 35 7 7 CD cord-334315-ymkrgj0h 61 36 ] ] -RRB- cord-334315-ymkrgj0h 61 37 . . . cord-334315-ymkrgj0h 62 1 Inactivation inactivation NN cord-334315-ymkrgj0h 62 2 of of IN cord-334315-ymkrgj0h 62 3 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 62 4 by by IN cord-334315-ymkrgj0h 62 5 Kunjin Kunjin NNP cord-334315-ymkrgj0h 62 6 virus virus NN cord-334315-ymkrgj0h 62 7 sfRNA sfrna NN cord-334315-ymkrgj0h 62 8 likely likely RB cord-334315-ymkrgj0h 62 9 causes cause VBZ cord-334315-ymkrgj0h 62 10 the the DT cord-334315-ymkrgj0h 62 11 stabilization stabilization NN cord-334315-ymkrgj0h 62 12 and and CC cord-334315-ymkrgj0h 62 13 increase increase NN cord-334315-ymkrgj0h 62 14 in in IN cord-334315-ymkrgj0h 62 15 abundance abundance NN cord-334315-ymkrgj0h 62 16 of of IN cord-334315-ymkrgj0h 62 17 numerous numerous JJ cord-334315-ymkrgj0h 62 18 short short RB cord-334315-ymkrgj0h 62 19 - - HYPH cord-334315-ymkrgj0h 62 20 lived live VBN cord-334315-ymkrgj0h 62 21 host host NN cord-334315-ymkrgj0h 62 22 transcripts transcript NNS cord-334315-ymkrgj0h 62 23 , , , cord-334315-ymkrgj0h 62 24 including include VBG cord-334315-ymkrgj0h 62 25 chemokines chemokine NNS cord-334315-ymkrgj0h 62 26 , , , cord-334315-ymkrgj0h 62 27 cytokines cytokine NNS cord-334315-ymkrgj0h 62 28 , , , cord-334315-ymkrgj0h 62 29 and and CC cord-334315-ymkrgj0h 62 30 cell cell NN cord-334315-ymkrgj0h 62 31 cycle cycle NN cord-334315-ymkrgj0h 62 32 regulators regulator NNS cord-334315-ymkrgj0h 62 33 [ [ -LRB- cord-334315-ymkrgj0h 62 34 6 6 CD cord-334315-ymkrgj0h 62 35 ] ] -RRB- cord-334315-ymkrgj0h 62 36 . . . cord-334315-ymkrgj0h 63 1 Dysregulation dysregulation NN cord-334315-ymkrgj0h 63 2 of of IN cord-334315-ymkrgj0h 63 3 these these DT cord-334315-ymkrgj0h 63 4 factors factor NNS cord-334315-ymkrgj0h 63 5 by by IN cord-334315-ymkrgj0h 63 6 Xrn1 xrn1 JJ cord-334315-ymkrgj0h 63 7 inhibition inhibition NN cord-334315-ymkrgj0h 63 8 may may MD cord-334315-ymkrgj0h 63 9 lead lead VB cord-334315-ymkrgj0h 63 10 to to IN cord-334315-ymkrgj0h 63 11 excessive excessive JJ cord-334315-ymkrgj0h 63 12 inflammation inflammation NN cord-334315-ymkrgj0h 63 13 , , , cord-334315-ymkrgj0h 63 14 dysregulation dysregulation NN cord-334315-ymkrgj0h 63 15 of of IN cord-334315-ymkrgj0h 63 16 the the DT cord-334315-ymkrgj0h 63 17 immune immune JJ cord-334315-ymkrgj0h 63 18 response response NN cord-334315-ymkrgj0h 63 19 , , , cord-334315-ymkrgj0h 63 20 and/or and/or CC cord-334315-ymkrgj0h 63 21 changes change NNS cord-334315-ymkrgj0h 63 22 in in IN cord-334315-ymkrgj0h 63 23 cell cell NN cord-334315-ymkrgj0h 63 24 growth growth NN cord-334315-ymkrgj0h 63 25 . . . cord-334315-ymkrgj0h 64 1 Recent recent JJ cord-334315-ymkrgj0h 64 2 work work NN cord-334315-ymkrgj0h 64 3 in in IN cord-334315-ymkrgj0h 64 4 yeast yeast NN cord-334315-ymkrgj0h 64 5 has have VBZ cord-334315-ymkrgj0h 64 6 demonstrated demonstrate VBN cord-334315-ymkrgj0h 64 7 the the DT cord-334315-ymkrgj0h 64 8 ability ability NN cord-334315-ymkrgj0h 64 9 of of IN cord-334315-ymkrgj0h 64 10 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 64 11 to to TO cord-334315-ymkrgj0h 64 12 enter enter VB cord-334315-ymkrgj0h 64 13 the the DT cord-334315-ymkrgj0h 64 14 nucleus nucleus NN cord-334315-ymkrgj0h 64 15 and and CC cord-334315-ymkrgj0h 64 16 influence influence NN cord-334315-ymkrgj0h 64 17 transcription transcription NN cord-334315-ymkrgj0h 64 18 rates rate NNS cord-334315-ymkrgj0h 64 19 , , , cord-334315-ymkrgj0h 64 20 thus thus RB cord-334315-ymkrgj0h 64 21 acting act VBG cord-334315-ymkrgj0h 64 22 as as IN cord-334315-ymkrgj0h 64 23 a a DT cord-334315-ymkrgj0h 64 24 link link NN cord-334315-ymkrgj0h 64 25 between between IN cord-334315-ymkrgj0h 64 26 RNA RNA NNP cord-334315-ymkrgj0h 64 27 decay decay NN cord-334315-ymkrgj0h 64 28 and and CC cord-334315-ymkrgj0h 64 29 transcription transcription NN cord-334315-ymkrgj0h 64 30 [ [ -LRB- cord-334315-ymkrgj0h 64 31 22 22 CD cord-334315-ymkrgj0h 64 32 ] ] -RRB- cord-334315-ymkrgj0h 64 33 . . . cord-334315-ymkrgj0h 65 1 Excitingly excitingly RB cord-334315-ymkrgj0h 65 2 , , , cord-334315-ymkrgj0h 65 3 the the DT cord-334315-ymkrgj0h 65 4 authors author NNS cord-334315-ymkrgj0h 65 5 found find VBD cord-334315-ymkrgj0h 65 6 that that IN cord-334315-ymkrgj0h 65 7 the the DT cord-334315-ymkrgj0h 65 8 exonucleolytic exonucleolytic JJ cord-334315-ymkrgj0h 65 9 activity activity NN cord-334315-ymkrgj0h 65 10 of of IN cord-334315-ymkrgj0h 65 11 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 65 12 was be VBD cord-334315-ymkrgj0h 65 13 also also RB cord-334315-ymkrgj0h 65 14 required require VBN cord-334315-ymkrgj0h 65 15 for for IN cord-334315-ymkrgj0h 65 16 the the DT cord-334315-ymkrgj0h 65 17 coupling coupling NN cord-334315-ymkrgj0h 65 18 between between IN cord-334315-ymkrgj0h 65 19 transcription transcription NN cord-334315-ymkrgj0h 65 20 and and CC cord-334315-ymkrgj0h 65 21 mRNA mrna NN cord-334315-ymkrgj0h 65 22 decay decay NN cord-334315-ymkrgj0h 65 23 . . . cord-334315-ymkrgj0h 66 1 Could Could MD cord-334315-ymkrgj0h 66 2 sfRNAmediated sfrnamediate VBN cord-334315-ymkrgj0h 66 3 inactivation inactivation NN cord-334315-ymkrgj0h 66 4 of of IN cord-334315-ymkrgj0h 66 5 Xrn1 Xrn1 NNP cord-334315-ymkrgj0h 66 6 cause cause VB cord-334315-ymkrgj0h 66 7 a a DT cord-334315-ymkrgj0h 66 8 defect defect NN cord-334315-ymkrgj0h 66 9 in in IN cord-334315-ymkrgj0h 66 10 the the DT cord-334315-ymkrgj0h 66 11 coordination coordination NN cord-334315-ymkrgj0h 66 12 of of IN cord-334315-ymkrgj0h 66 13 RNA RNA NNP cord-334315-ymkrgj0h 66 14 decay decay NN cord-334315-ymkrgj0h 66 15 and and CC cord-334315-ymkrgj0h 66 16 transcription transcription NN cord-334315-ymkrgj0h 66 17 in in IN cord-334315-ymkrgj0h 66 18 the the DT cord-334315-ymkrgj0h 66 19 host host NN cord-334315-ymkrgj0h 66 20 ? ? . cord-334315-ymkrgj0h 67 1 If if IN cord-334315-ymkrgj0h 67 2 so so RB cord-334315-ymkrgj0h 67 3 , , , cord-334315-ymkrgj0h 67 4 this this DT cord-334315-ymkrgj0h 67 5 could could MD cord-334315-ymkrgj0h 67 6 dramatically dramatically RB cord-334315-ymkrgj0h 67 7 alter alter VB cord-334315-ymkrgj0h 67 8 host host NN cord-334315-ymkrgj0h 67 9 gene gene NN cord-334315-ymkrgj0h 67 10 expression expression NN cord-334315-ymkrgj0h 67 11 and and CC cord-334315-ymkrgj0h 67 12 directly directly RB cord-334315-ymkrgj0h 67 13 influence influence VB cord-334315-ymkrgj0h 67 14 pathogenesis pathogenesis NN cord-334315-ymkrgj0h 67 15 . . . cord-334315-ymkrgj0h 68 1 Viral viral JJ cord-334315-ymkrgj0h 68 2 RNAs rna NNS cord-334315-ymkrgj0h 68 3 have have VBP cord-334315-ymkrgj0h 68 4 evolved evolve VBN cord-334315-ymkrgj0h 68 5 a a DT cord-334315-ymkrgj0h 68 6 wide wide JJ cord-334315-ymkrgj0h 68 7 variety variety NN cord-334315-ymkrgj0h 68 8 of of IN cord-334315-ymkrgj0h 68 9 mechanisms mechanism NNS cord-334315-ymkrgj0h 68 10 to to TO cord-334315-ymkrgj0h 68 11 successfully successfully RB cord-334315-ymkrgj0h 68 12 interface interface VB cord-334315-ymkrgj0h 68 13 with with IN cord-334315-ymkrgj0h 68 14 the the DT cord-334315-ymkrgj0h 68 15 host host NN cord-334315-ymkrgj0h 68 16 RNA RNA NNP cord-334315-ymkrgj0h 68 17 decay decay NN cord-334315-ymkrgj0h 68 18 machinery machinery NN cord-334315-ymkrgj0h 68 19 . . . cord-334315-ymkrgj0h 69 1 In in IN cord-334315-ymkrgj0h 69 2 fact fact NN cord-334315-ymkrgj0h 69 3 , , , cord-334315-ymkrgj0h 69 4 some some DT cord-334315-ymkrgj0h 69 5 of of IN cord-334315-ymkrgj0h 69 6 the the DT cord-334315-ymkrgj0h 69 7 most most RBS cord-334315-ymkrgj0h 69 8 important important JJ cord-334315-ymkrgj0h 69 9 questions question NNS cord-334315-ymkrgj0h 69 10 in in IN cord-334315-ymkrgj0h 69 11 this this DT cord-334315-ymkrgj0h 69 12 field field NN cord-334315-ymkrgj0h 69 13 have have VBP cord-334315-ymkrgj0h 69 14 yet yet RB cord-334315-ymkrgj0h 69 15 to to TO cord-334315-ymkrgj0h 69 16 be be VB cord-334315-ymkrgj0h 69 17 answered answer VBN cord-334315-ymkrgj0h 69 18 . . . cord-334315-ymkrgj0h 70 1 What what WP cord-334315-ymkrgj0h 70 2 are be VBP cord-334315-ymkrgj0h 70 3 the the DT cord-334315-ymkrgj0h 70 4 consequences consequence NNS cord-334315-ymkrgj0h 70 5 of of IN cord-334315-ymkrgj0h 70 6 viral viral JJ cord-334315-ymkrgj0h 70 7 inactivation inactivation NN cord-334315-ymkrgj0h 70 8 of of IN cord-334315-ymkrgj0h 70 9 decay decay NN cord-334315-ymkrgj0h 70 10 factors factor NNS cord-334315-ymkrgj0h 70 11 like like IN cord-334315-ymkrgj0h 70 12 Xrn1 xrn1 NN cord-334315-ymkrgj0h 70 13 in in IN cord-334315-ymkrgj0h 70 14 terms term NNS cord-334315-ymkrgj0h 70 15 of of IN cord-334315-ymkrgj0h 70 16 disease disease NN cord-334315-ymkrgj0h 70 17 ? ? . cord-334315-ymkrgj0h 71 1 Can Can MD cord-334315-ymkrgj0h 71 2 viruses virus NNS cord-334315-ymkrgj0h 71 3 also also RB cord-334315-ymkrgj0h 71 4 influence influence VB cord-334315-ymkrgj0h 71 5 host host NN cord-334315-ymkrgj0h 71 6 transcription transcription NN cord-334315-ymkrgj0h 71 7 by by IN cord-334315-ymkrgj0h 71 8 manipulating manipulate VBG cord-334315-ymkrgj0h 71 9 RNA RNA NNP cord-334315-ymkrgj0h 71 10 decay decay NN cord-334315-ymkrgj0h 71 11 pathways pathway NNS cord-334315-ymkrgj0h 71 12 to to IN cord-334315-ymkrgj0h 71 13 short short JJ cord-334315-ymkrgj0h 71 14 - - HYPH cord-334315-ymkrgj0h 71 15 circuit circuit NN cord-334315-ymkrgj0h 71 16 feedback feedback NN cord-334315-ymkrgj0h 71 17 regulatory regulatory JJ cord-334315-ymkrgj0h 71 18 mechanisms mechanism NNS cord-334315-ymkrgj0h 71 19 ? ? . cord-334315-ymkrgj0h 72 1 How how WRB cord-334315-ymkrgj0h 72 2 do do VBP cord-334315-ymkrgj0h 72 3 virusinduced virusinduce VBN cord-334315-ymkrgj0h 72 4 changes change NNS cord-334315-ymkrgj0h 72 5 in in IN cord-334315-ymkrgj0h 72 6 RNA RNA NNP cord-334315-ymkrgj0h 72 7 decay decay NN cord-334315-ymkrgj0h 72 8 pathways pathway NNS cord-334315-ymkrgj0h 72 9 interface interface NN cord-334315-ymkrgj0h 72 10 with with IN cord-334315-ymkrgj0h 72 11 potential potential JJ cord-334315-ymkrgj0h 72 12 changes change NNS cord-334315-ymkrgj0h 72 13 in in IN cord-334315-ymkrgj0h 72 14 innate innate JJ cord-334315-ymkrgj0h 72 15 immune immune JJ cord-334315-ymkrgj0h 72 16 responses response NNS cord-334315-ymkrgj0h 72 17 ? ? . cord-334315-ymkrgj0h 73 1 Virus virus NN cord-334315-ymkrgj0h 73 2 families family NNS cord-334315-ymkrgj0h 73 3 often often RB cord-334315-ymkrgj0h 73 4 use use VBP cord-334315-ymkrgj0h 73 5 conserved conserve VBN cord-334315-ymkrgj0h 73 6 strategies strategy NNS cord-334315-ymkrgj0h 73 7 to to TO cord-334315-ymkrgj0h 73 8 evade evade VB cord-334315-ymkrgj0h 73 9 the the DT cord-334315-ymkrgj0h 73 10 cellular cellular JJ cord-334315-ymkrgj0h 73 11 RNA RNA NNP cord-334315-ymkrgj0h 73 12 decay decay NN cord-334315-ymkrgj0h 73 13 machinery machinery NN cord-334315-ymkrgj0h 73 14 . . . cord-334315-ymkrgj0h 74 1 Therefore therefore RB cord-334315-ymkrgj0h 74 2 , , , cord-334315-ymkrgj0h 74 3 perhaps perhaps RB cord-334315-ymkrgj0h 74 4 researchers researcher NNS cord-334315-ymkrgj0h 74 5 can can MD cord-334315-ymkrgj0h 74 6 develop develop VB cord-334315-ymkrgj0h 74 7 effective effective JJ cord-334315-ymkrgj0h 74 8 , , , cord-334315-ymkrgj0h 74 9 broad broad JJ cord-334315-ymkrgj0h 74 10 - - HYPH cord-334315-ymkrgj0h 74 11 spectrum spectrum NN cord-334315-ymkrgj0h 74 12 antivirals antiviral NNS cord-334315-ymkrgj0h 74 13 to to TO cord-334315-ymkrgj0h 74 14 disarm disarm VB cord-334315-ymkrgj0h 74 15 these these DT cord-334315-ymkrgj0h 74 16 strategies strategy NNS cord-334315-ymkrgj0h 74 17 and and CC cord-334315-ymkrgj0h 74 18 destabilize destabilize VB cord-334315-ymkrgj0h 74 19 viral viral JJ cord-334315-ymkrgj0h 74 20 RNAs rna NNS cord-334315-ymkrgj0h 74 21 . . . cord-334315-ymkrgj0h 75 1 Future future JJ cord-334315-ymkrgj0h 75 2 research research NN cord-334315-ymkrgj0h 75 3 in in IN cord-334315-ymkrgj0h 75 4 this this DT cord-334315-ymkrgj0h 75 5 burgeoning burgeon VBG cord-334315-ymkrgj0h 75 6 field field NN cord-334315-ymkrgj0h 75 7 will will MD cord-334315-ymkrgj0h 75 8 likely likely RB cord-334315-ymkrgj0h 75 9 uncover uncover VB cord-334315-ymkrgj0h 75 10 novel novel JJ cord-334315-ymkrgj0h 75 11 mechanisms mechanism NNS cord-334315-ymkrgj0h 75 12 of of IN cord-334315-ymkrgj0h 75 13 the the DT cord-334315-ymkrgj0h 75 14 regulation regulation NN cord-334315-ymkrgj0h 75 15 of of IN cord-334315-ymkrgj0h 75 16 host host NN cord-334315-ymkrgj0h 75 17 and and CC cord-334315-ymkrgj0h 75 18 viral viral JJ cord-334315-ymkrgj0h 75 19 gene gene NN cord-334315-ymkrgj0h 75 20 expression expression NN cord-334315-ymkrgj0h 75 21 and and CC cord-334315-ymkrgj0h 75 22 facilitate facilitate VB cord-334315-ymkrgj0h 75 23 new new JJ cord-334315-ymkrgj0h 75 24 methods method NNS cord-334315-ymkrgj0h 75 25 for for IN cord-334315-ymkrgj0h 75 26 treating treat VBG cord-334315-ymkrgj0h 75 27 viral viral JJ cord-334315-ymkrgj0h 75 28 diseases disease NNS cord-334315-ymkrgj0h 75 29 . . . cord-334315-ymkrgj0h 76 1 Regulation regulation NN cord-334315-ymkrgj0h 76 2 of of IN cord-334315-ymkrgj0h 76 3 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 76 4 mRNA mrna NN cord-334315-ymkrgj0h 76 5 decay decay NN cord-334315-ymkrgj0h 76 6 Conservation Conservation NNP cord-334315-ymkrgj0h 76 7 of of IN cord-334315-ymkrgj0h 76 8 a a DT cord-334315-ymkrgj0h 76 9 triple triple JJ cord-334315-ymkrgj0h 76 10 - - HYPH cord-334315-ymkrgj0h 76 11 helix helix NN cord-334315-ymkrgj0h 76 12 - - HYPH cord-334315-ymkrgj0h 76 13 forming form VBG cord-334315-ymkrgj0h 76 14 RNA RNA NNP cord-334315-ymkrgj0h 76 15 stability stability NN cord-334315-ymkrgj0h 76 16 element element NN cord-334315-ymkrgj0h 76 17 in in IN cord-334315-ymkrgj0h 76 18 noncoding noncoding JJ cord-334315-ymkrgj0h 76 19 and and CC cord-334315-ymkrgj0h 76 20 genomic genomic JJ cord-334315-ymkrgj0h 76 21 RNAs rna NNS cord-334315-ymkrgj0h 76 22 of of IN cord-334315-ymkrgj0h 76 23 diverse diverse JJ cord-334315-ymkrgj0h 76 24 viruses virus NNS cord-334315-ymkrgj0h 76 25 Poliovirus Poliovirus NNP cord-334315-ymkrgj0h 76 26 - - HYPH cord-334315-ymkrgj0h 76 27 mediated mediate VBN cord-334315-ymkrgj0h 76 28 disruption disruption NN cord-334315-ymkrgj0h 76 29 of of IN cord-334315-ymkrgj0h 76 30 cytoplasmic cytoplasmic JJ cord-334315-ymkrgj0h 76 31 processing processing NN cord-334315-ymkrgj0h 76 32 bodies body NNS cord-334315-ymkrgj0h 77 1 Picornavirus Picornavirus NNP cord-334315-ymkrgj0h 77 2 modification modification NN cord-334315-ymkrgj0h 77 3 of of IN cord-334315-ymkrgj0h 77 4 a a DT cord-334315-ymkrgj0h 77 5 host host NN cord-334315-ymkrgj0h 77 6 mRNA mRNA NNP cord-334315-ymkrgj0h 77 7 decay decay NN cord-334315-ymkrgj0h 77 8 protein protein NN cord-334315-ymkrgj0h 77 9 Cellular Cellular NNP cord-334315-ymkrgj0h 77 10 mRNA mrna NN cord-334315-ymkrgj0h 77 11 Decay decay NN cord-334315-ymkrgj0h 77 12 Protein Protein NNP cord-334315-ymkrgj0h 77 13 AUF1 AUF1 NNP cord-334315-ymkrgj0h 78 1 Negatively negatively RB cord-334315-ymkrgj0h 78 2 Regulates regulate VBZ cord-334315-ymkrgj0h 78 3 Enterovirus Enterovirus NNP cord-334315-ymkrgj0h 78 4 and and CC cord-334315-ymkrgj0h 78 5 Human Human NNP cord-334315-ymkrgj0h 78 6 Rhinovirus Rhinovirus NNP cord-334315-ymkrgj0h 78 7 Infections Infections NNPS cord-334315-ymkrgj0h 78 8 Diversion diversion NN cord-334315-ymkrgj0h 78 9 of of IN cord-334315-ymkrgj0h 78 10 stress stress NN cord-334315-ymkrgj0h 78 11 granules granule NNS cord-334315-ymkrgj0h 78 12 and and CC cord-334315-ymkrgj0h 78 13 P p NN cord-334315-ymkrgj0h 78 14 - - HYPH cord-334315-ymkrgj0h 78 15 bodies body NNS cord-334315-ymkrgj0h 78 16 during during IN cord-334315-ymkrgj0h 78 17 viral viral JJ cord-334315-ymkrgj0h 78 18 infection infection NN cord-334315-ymkrgj0h 78 19 RNA RNA NNP cord-334315-ymkrgj0h 78 20 structures structure NNS cord-334315-ymkrgj0h 78 21 required require VBN cord-334315-ymkrgj0h 78 22 for for IN cord-334315-ymkrgj0h 78 23 production production NN cord-334315-ymkrgj0h 78 24 of of IN cord-334315-ymkrgj0h 78 25 subgenomic subgenomic NNP cord-334315-ymkrgj0h 78 26 flavivirus flavivirus NNP cord-334315-ymkrgj0h 78 27 RNA RNA NNP cord-334315-ymkrgj0h 78 28 An An NNP cord-334315-ymkrgj0h 78 29 RNA RNA NNP cord-334315-ymkrgj0h 78 30 pseudoknot pseudoknot NN cord-334315-ymkrgj0h 78 31 is be VBZ cord-334315-ymkrgj0h 78 32 required require VBN cord-334315-ymkrgj0h 78 33 for for IN cord-334315-ymkrgj0h 78 34 production production NN cord-334315-ymkrgj0h 78 35 of of IN cord-334315-ymkrgj0h 78 36 yellow yellow JJ cord-334315-ymkrgj0h 78 37 fever fever NNP cord-334315-ymkrgj0h 78 38 virus virus NN cord-334315-ymkrgj0h 78 39 subgenomic subgenomic NNP cord-334315-ymkrgj0h 78 40 RNA RNA NNP cord-334315-ymkrgj0h 78 41 by by IN cord-334315-ymkrgj0h 78 42 the the DT cord-334315-ymkrgj0h 78 43 host host NN cord-334315-ymkrgj0h 78 44 nuclease nuclease NN cord-334315-ymkrgj0h 79 1 XRN1 XRN1 NNP cord-334315-ymkrgj0h 79 2 A a DT cord-334315-ymkrgj0h 79 3 noncoding noncoding JJ cord-334315-ymkrgj0h 79 4 RNA rna NN cord-334315-ymkrgj0h 79 5 produced produce VBN cord-334315-ymkrgj0h 79 6 by by IN cord-334315-ymkrgj0h 79 7 arthropod arthropod NN cord-334315-ymkrgj0h 79 8 - - HYPH cord-334315-ymkrgj0h 79 9 borne bear VBN cord-334315-ymkrgj0h 79 10 flaviviruses flavivirus NNS cord-334315-ymkrgj0h 79 11 inhibits inhibit VBZ cord-334315-ymkrgj0h 79 12 the the DT cord-334315-ymkrgj0h 79 13 cellular cellular JJ cord-334315-ymkrgj0h 79 14 exoribonuclease exoribonuclease NN cord-334315-ymkrgj0h 79 15 XRN1 XRN1 NNP cord-334315-ymkrgj0h 79 16 and and CC cord-334315-ymkrgj0h 79 17 alters alter VBZ cord-334315-ymkrgj0h 79 18 host host NN cord-334315-ymkrgj0h 79 19 mRNA mrna NN cord-334315-ymkrgj0h 79 20 stability stability NN cord-334315-ymkrgj0h 80 1 A a DT cord-334315-ymkrgj0h 80 2 highly highly RB cord-334315-ymkrgj0h 80 3 structured structured JJ cord-334315-ymkrgj0h 80 4 , , , cord-334315-ymkrgj0h 80 5 nuclease nuclease NN cord-334315-ymkrgj0h 80 6 - - HYPH cord-334315-ymkrgj0h 80 7 resistant resistant JJ cord-334315-ymkrgj0h 80 8 , , , cord-334315-ymkrgj0h 80 9 noncoding noncoding JJ cord-334315-ymkrgj0h 80 10 RNA RNA NNP cord-334315-ymkrgj0h 80 11 produced produce VBN cord-334315-ymkrgj0h 80 12 by by IN cord-334315-ymkrgj0h 80 13 flaviviruses flavivirus NNS cord-334315-ymkrgj0h 80 14 is be VBZ cord-334315-ymkrgj0h 80 15 required require VBN cord-334315-ymkrgj0h 80 16 for for IN cord-334315-ymkrgj0h 80 17 pathogenicity pathogenicity NN cord-334315-ymkrgj0h 80 18 complexes complex NNS cord-334315-ymkrgj0h 80 19 bind bind VBP cord-334315-ymkrgj0h 80 20 to to IN cord-334315-ymkrgj0h 80 21 specific specific JJ cord-334315-ymkrgj0h 80 22 sites site NNS cord-334315-ymkrgj0h 80 23 in in IN cord-334315-ymkrgj0h 80 24 viral viral JJ cord-334315-ymkrgj0h 80 25 RNA RNA NNP cord-334315-ymkrgj0h 80 26 genomes genome NNS cord-334315-ymkrgj0h 80 27 and and CC cord-334315-ymkrgj0h 80 28 regulate regulate VB cord-334315-ymkrgj0h 80 29 their -PRON- PRP$ cord-334315-ymkrgj0h 80 30 translation translation NN cord-334315-ymkrgj0h 80 31 and and CC cord-334315-ymkrgj0h 80 32 replication replication NN cord-334315-ymkrgj0h 80 33 Translation translation NN cord-334315-ymkrgj0h 80 34 and and CC cord-334315-ymkrgj0h 80 35 replication replication NN cord-334315-ymkrgj0h 80 36 of of IN cord-334315-ymkrgj0h 80 37 hepatitis hepatitis NN cord-334315-ymkrgj0h 80 38 C C NNP cord-334315-ymkrgj0h 80 39 virus virus NN cord-334315-ymkrgj0h 80 40 genomic genomic JJ cord-334315-ymkrgj0h 80 41 RNA RNA NNP cord-334315-ymkrgj0h 80 42 depends depend VBZ cord-334315-ymkrgj0h 80 43 on on IN cord-334315-ymkrgj0h 80 44 ancient ancient JJ cord-334315-ymkrgj0h 80 45 cellular cellular JJ cord-334315-ymkrgj0h 80 46 proteins protein NNS cord-334315-ymkrgj0h 80 47 that that WDT cord-334315-ymkrgj0h 80 48 control control VBP cord-334315-ymkrgj0h 80 49 mRNA mrna NN cord-334315-ymkrgj0h 80 50 fates fate NNS cord-334315-ymkrgj0h 81 1 Lsm Lsm NNP cord-334315-ymkrgj0h 81 2 proteins protein NNS cord-334315-ymkrgj0h 81 3 bind bind VBP cord-334315-ymkrgj0h 81 4 and and CC cord-334315-ymkrgj0h 81 5 stabilize stabilize VBP cord-334315-ymkrgj0h 81 6 RNAs rna NNS cord-334315-ymkrgj0h 81 7 containing contain VBG cord-334315-ymkrgj0h 81 8 59 59 CD cord-334315-ymkrgj0h 81 9 poly(A poly(a JJ cord-334315-ymkrgj0h 81 10 ) ) -RRB- cord-334315-ymkrgj0h 81 11 tracts tract NNS cord-334315-ymkrgj0h 82 1 A a DT cord-334315-ymkrgj0h 82 2 genome genome NN cord-334315-ymkrgj0h 82 3 - - HYPH cord-334315-ymkrgj0h 82 4 wide wide JJ cord-334315-ymkrgj0h 82 5 RNAi RNAi NNS cord-334315-ymkrgj0h 82 6 screen screen NN cord-334315-ymkrgj0h 82 7 reveals reveal VBZ cord-334315-ymkrgj0h 82 8 that that IN cord-334315-ymkrgj0h 82 9 mRNA mRNA NNP cord-334315-ymkrgj0h 82 10 decapping decapping NN cord-334315-ymkrgj0h 82 11 restricts restrict VBZ cord-334315-ymkrgj0h 82 12 bunyaviral bunyaviral JJ cord-334315-ymkrgj0h 82 13 replication replication NN cord-334315-ymkrgj0h 82 14 by by IN cord-334315-ymkrgj0h 82 15 limiting limit VBG cord-334315-ymkrgj0h 82 16 the the DT cord-334315-ymkrgj0h 82 17 pools pool NNS cord-334315-ymkrgj0h 82 18 of of IN cord-334315-ymkrgj0h 82 19 Dcp2-accessible dcp2-accessible JJ cord-334315-ymkrgj0h 82 20 targets target NNS cord-334315-ymkrgj0h 82 21 for for IN cord-334315-ymkrgj0h 82 22 capsnatching capsnatche VBG cord-334315-ymkrgj0h 82 23 Sindbis Sindbis NNP cord-334315-ymkrgj0h 82 24 virus virus NN cord-334315-ymkrgj0h 82 25 usurps usurp VBZ cord-334315-ymkrgj0h 82 26 the the DT cord-334315-ymkrgj0h 82 27 cellular cellular JJ cord-334315-ymkrgj0h 82 28 HuR hur NN cord-334315-ymkrgj0h 82 29 protein protein NN cord-334315-ymkrgj0h 82 30 to to TO cord-334315-ymkrgj0h 82 31 stabilize stabilize VB cord-334315-ymkrgj0h 82 32 its -PRON- PRP$ cord-334315-ymkrgj0h 82 33 transcripts transcript NNS cord-334315-ymkrgj0h 82 34 and and CC cord-334315-ymkrgj0h 82 35 promote promote VB cord-334315-ymkrgj0h 82 36 productive productive JJ cord-334315-ymkrgj0h 82 37 infections infection NNS cord-334315-ymkrgj0h 82 38 in in IN cord-334315-ymkrgj0h 82 39 mammalian mammalian JJ cord-334315-ymkrgj0h 82 40 and and CC cord-334315-ymkrgj0h 82 41 mosquito mosquito NN cord-334315-ymkrgj0h 82 42 cells cell NNS cord-334315-ymkrgj0h 82 43 Dephosphorylation Dephosphorylation NNP cord-334315-ymkrgj0h 82 44 of of IN cord-334315-ymkrgj0h 82 45 HuR hur NN cord-334315-ymkrgj0h 82 46 protein protein NN cord-334315-ymkrgj0h 82 47 during during IN cord-334315-ymkrgj0h 82 48 alphavirus alphavirus NNP cord-334315-ymkrgj0h 82 49 infection infection NN cord-334315-ymkrgj0h 82 50 is be VBZ cord-334315-ymkrgj0h 82 51 associated associate VBN cord-334315-ymkrgj0h 82 52 with with IN cord-334315-ymkrgj0h 82 53 HuR HuR NNP cord-334315-ymkrgj0h 82 54 relocalization relocalization NNP cord-334315-ymkrgj0h 82 55 to to IN cord-334315-ymkrgj0h 82 56 the the DT cord-334315-ymkrgj0h 82 57 cytoplasm cytoplasm NN cord-334315-ymkrgj0h 83 1 The the DT cord-334315-ymkrgj0h 83 2 39 39 CD cord-334315-ymkrgj0h 83 3 untranslated untranslated JJ cord-334315-ymkrgj0h 83 4 region region NN cord-334315-ymkrgj0h 83 5 of of IN cord-334315-ymkrgj0h 83 6 the the DT cord-334315-ymkrgj0h 83 7 rabies rabies NN cord-334315-ymkrgj0h 83 8 virus virus NN cord-334315-ymkrgj0h 83 9 glycoprotein glycoprotein NN cord-334315-ymkrgj0h 83 10 mRNA mRNA NNP cord-334315-ymkrgj0h 83 11 specifically specifically RB cord-334315-ymkrgj0h 83 12 interacts interact VBZ cord-334315-ymkrgj0h 83 13 with with IN cord-334315-ymkrgj0h 83 14 cellular cellular JJ cord-334315-ymkrgj0h 83 15 PCBP2 PCBP2 NNP cord-334315-ymkrgj0h 83 16 protein protein NN cord-334315-ymkrgj0h 83 17 and and CC cord-334315-ymkrgj0h 83 18 promotes promote VBZ cord-334315-ymkrgj0h 83 19 transcript transcript NN cord-334315-ymkrgj0h 83 20 stability stability NN cord-334315-ymkrgj0h 83 21 Poly(rC poly(rc CD cord-334315-ymkrgj0h 83 22 ) ) -RRB- cord-334315-ymkrgj0h 84 1 binding bind VBG cord-334315-ymkrgj0h 84 2 proteins protein NNS cord-334315-ymkrgj0h 84 3 mediate mediate VBP cord-334315-ymkrgj0h 84 4 poliovirus poliovirus NN cord-334315-ymkrgj0h 84 5 mRNA mrna NN cord-334315-ymkrgj0h 84 6 stability stability NN cord-334315-ymkrgj0h 84 7 Down down IN cord-334315-ymkrgj0h 84 8 - - HYPH cord-334315-ymkrgj0h 84 9 regulation regulation NN cord-334315-ymkrgj0h 84 10 of of IN cord-334315-ymkrgj0h 84 11 a a DT cord-334315-ymkrgj0h 84 12 host host NN cord-334315-ymkrgj0h 84 13 microRNA microRNA NNP cord-334315-ymkrgj0h 84 14 by by IN cord-334315-ymkrgj0h 84 15 a a DT cord-334315-ymkrgj0h 84 16 Herpesvirus Herpesvirus NNP cord-334315-ymkrgj0h 84 17 saimiri saimiri NNP cord-334315-ymkrgj0h 84 18 noncoding noncoding NNP cord-334315-ymkrgj0h 84 19 RNA RNA NNP cord-334315-ymkrgj0h 84 20 Virus Virus NNP cord-334315-ymkrgj0h 84 21 - - HYPH cord-334315-ymkrgj0h 84 22 encoded encode VBN cord-334315-ymkrgj0h 84 23 endonucleases endonuclease NNS cord-334315-ymkrgj0h 84 24 : : : cord-334315-ymkrgj0h 84 25 expected expect VBN cord-334315-ymkrgj0h 84 26 and and CC cord-334315-ymkrgj0h 84 27 novel novel NN cord-334315-ymkrgj0h 84 28 functions function NNS cord-334315-ymkrgj0h 85 1 A a DT cord-334315-ymkrgj0h 85 2 common common JJ cord-334315-ymkrgj0h 85 3 strategy strategy NN cord-334315-ymkrgj0h 85 4 for for IN cord-334315-ymkrgj0h 85 5 host host NN cord-334315-ymkrgj0h 85 6 RNA RNA NNP cord-334315-ymkrgj0h 85 7 degradation degradation NN cord-334315-ymkrgj0h 85 8 by by IN cord-334315-ymkrgj0h 85 9 divergent divergent JJ cord-334315-ymkrgj0h 85 10 viruses virus NNS cord-334315-ymkrgj0h 85 11 Gene Gene NNP cord-334315-ymkrgj0h 85 12 expression expression NN cord-334315-ymkrgj0h 85 13 is be VBZ cord-334315-ymkrgj0h 85 14 circular circular JJ cord-334315-ymkrgj0h 85 15 : : : cord-334315-ymkrgj0h 85 16 factors factor NNS cord-334315-ymkrgj0h 85 17 for for IN cord-334315-ymkrgj0h 85 18 mRNA mRNA NNP cord-334315-ymkrgj0h 85 19 degradation degradation NN cord-334315-ymkrgj0h 85 20 also also RB cord-334315-ymkrgj0h 85 21 foster foster VBP cord-334315-ymkrgj0h 85 22 mRNA mRNA NNP cord-334315-ymkrgj0h 85 23 synthesis synthesis NN