id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002244-5h6monh3	Lee, Seung Hoon	PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs	2016-10-06		.txt	text/plain	4148	279	49	Immunohistochemical analysis revealed that injection with PTEN overexpression vector significantly suppressed the expression of proinflammatory cytokines and osteoclastogenesis related factor such as RANKL and TRAP in joints compared to CIA mice treated with mock vector (Fig. 1D,E) . However, the differentiation of Treg cell was promoted in CIA induced mice injected with PTEN overexpression vector ( Fig. 2A) . However, the number of CD4 + p-Foxp3 + T cells in the spleen tissues of CIA induced mice was significantly upregulated compared to that in the spleen tissues of mice treated with mock vector based on immunofluorescence confocal microscopy ( Fig. 2C,D) . (A,B) Relative mRNA levels of PTEN and factors such as IL-17, RORγ t, and Foxp3 involved in the differentiation of Th17 and Treg in splenic CD4 + T cells, splenocytes, and draining lymph nodes from CIA induced WT or p53 −/− mice were assessed by real-time PCR.	./cache/cord-002244-5h6monh3.txt	./txt/cord-002244-5h6monh3.txt