key: cord-288732-k763ejqb
authors: ElMajjaoui, Sanaa; Ismaili, Nabil; Benjaafar, Noureddine
title: COVID-19, Brachytherapy, and Gynecologic Cancers: a Moroccan Experience
date: 2020-07-15
journal: SN Compr Clin Med
DOI: 10.1007/s42399-020-00402-0
sha: 
doc_id: 288732
cord_uid: k763ejqb

The treatment of gynecological cancers is the main activity of brachytherapy units. However, during COVID-19 pandemic, precautions should be done in order to reduce the spread of the virus while maintaining all chances to recovery for all patients (Radiother Oncol 148, 227-228, 2020). Despite the extent of the pandemic in our country, limited data are available to establish recommendations with a sufficient level of evidence (Radiother Oncol 148, 227-228, 2020). More recently, the American Brachytherapy Society published some clarifications in this regard and international expert consensus recommendations of radiation therapy for gynecologic malignancies during the COVID-19 pandemic were published (https://www.americanbrachytherapy.org/about-abs/abs-news/abs-statement-on-coronavirus/, Gynecol Oncol 15, 2020). In this commentary, we sought to share the procedures adopted for the management of gynecological cancer patients during COVID-19 pandemic in our brachytherapy unit.

Despite the extent of the pandemic in our country, limited data are available to establish recommendations with a sufficient level of evidence [1] . More recently, the American Brachytherapy Society published some clarifications in this regard and international expert consensus recommendations of radiation therapy for gynecologic malignancies during the COVID-19 pandemic were published [2, 3] . In this commentary, we sought to share the procedures adopted for the management of gynecological cancer patients during COVID-19 pandemic in our brachytherapy unit. This article is part of the Topical Collection on Cervical cancer is the most common gynecological cancer in our country. In the majority of cases, the treatment is based on EBRT (exclusive in early stages and with concurrent chemotherapy in locally advanced stages), followed by intracavitary brachytherapy (ICBT) which constitutes a cornerstone in its management [4] . Brachytherapy is one of the radiotherapy techniques offering the most interesting therapeutic index by delivering high doses in a very conformational way. However, omission of brachytherapy results in important reduction in the curative potential of treatment [5] . The development of high-dose rate brachytherapy guided by imaging, as well as endo-cavitary and interstitial hybrid techniques and dose escalation strategies [6] , has contributed more in improving local control and overall survival (OS) while reducing rate of late urinary, intestinal, and gynecological toxicities [7] [8] [9] . Technical advances in EBRT (IMRT, VMAT, and stereotaxic radiotherapy) have led to replacing brachytherapy boost by RT boost [10, 11] . However, local control, progression-free survival (PFS), and safety were significantly better with brachytherapy [12] [13] [14] [15] [16] . Therefore, ICBT boost remains the procedure of choice. Brachytherapy should be delivered immediately after EBRT. Longer treatment duration has been shown to be a worse prognostic factor for local control (an overall duration of treatment that exceeds 56 days results in a loss of 1% of local control per day) [17] [18] [19] [20] [21] [22] . This encourages us to respect as much as possible the time between EBRT and brachytherapy. Therefore, there are no major changes in brachytherapy procedures for patients with cervical cancers. However, to minimize the risk of contamination, precautionary measures have been implemented:

& Prefer the schemes with a reduced number of fractions: 3 × 8 Gy or 4 × 7 Gy. In our unit, we use the HDR ICBT schedule of 7 Gy per fraction for 4 fractions in 2 insertions 1 week apart. For each insertion, the patients receive 2 fractions per day separated by a 6-h interval [3, 17] . For patients over 70 years of age or with significant comorbidities (chronic respiratory or cardiac pathology, immunosuppression, etc.) who have small tumors or responding well to external beam radiotherapy (EBRT), a more shortened schedule of 9 Gy per fraction in 2 fractions at 1 week apart may be considered. [23, 24] & The brachytherapy program is adapted by limiting number of patients hospitalized, without compromising the treatment time duration.

Patients without COVID-19 symptoms, who have already started their ICBT, should complete their schedule without delay. Under normal conditions, all ICBT applications are done using spinal anesthesia and ultrasound guidance; however, the concern during covid-19 pandemic is the lack of anesthesiologist and their staff [17] . In this case, we may consider pudendal nerve block or local anesthesia by paracervical block, or by the use of medical hypnosis technique [17] . If all of these tools are not available, consider to insert applicator with uterine tandem which diameter not exceeding 4 mm, without anesthesia. For COVID-19-positive patient, delivering ICBT on time is recommended. However, in our department, as well as in other centers, we have only one brachytherapy operating room and a single bunker. Therefore, treatment should be postponed for at least 24 days or until the infection is resolved.

For patients with early endometrial cancer, surgical treatment remains the standard of care. Adjuvant treatment by EBRT and/or brachytherapy is recommended according to the prognostic factors in the anatomopathological report. Vaginal vault brachytherapy (VVB) is recommended in intermediate risk endometrial cancer. It significantly reduces the rate of vaginal relapse. However, there is no significant difference in terms of long-term relapse, DFS, or OS [25, 26] . Consequently, delaying VVB may be appropriate for this risk group. In the setting of COVID-19 outbreak, we suggest postponing brachytherapy up to 12 weeks [3] . For patients with significant comorbidities, exposing them to the risk of severe complications of COVID-19 infection (old age, chronic respiratory or cardiac diseases, immunosuppression, etc.), it may be judicious to delay brachytherapy for 6 months. For patients who should start VVB, consider the schedule of 7 Gy for 3fractions to a depth dose of 0.5 cm, to limit the number of patient displacement. An interval spacing of 14 days between the fractions is also acceptable. However, for high-risk patients who received adjuvant external RT, omitting BVV may be reasonable because of no evidence for combining of RT and VVB (except in the case of positive margins) [2, 17] . For stage II endometrial cancers, adjuvant VVB is delivered exclusively (if invasion < 50% of the myometrium, G1 and 2) or after EBRT (if invasion > 50% of the myometrium, G3). In both cases, consider to postpone brachytherapy by 1 to 2 months. In the case of a COVID-19 positive patient, postpone treatment for at least 24 days [2].

For early vaginal cancer (stage I, < 5 mm of invasion), exclusive brachytherapy is the treatment of choice with EQD2 of 60-75 Gy to the tumor with 2 cm margin (7 Gy for 5 fractions) [3] . In patients with significant comorbidities (old age, chronic respiratory pathology or cardiac, immunosuppression ...), consider to postpone brachytherapy by 1 to 2 months. For advanced stage, which represent the vast majority of cases, consider radio(chemotherapy) treatment followed by vaginal brachytherapy (7 Gy for 3 fractions) [3] . Brachytherapy treatment should be started on time without any delay.

Prioritization list in gynecological brachytherapy: Contributors All authors contributed to the conception and design, drafting, and critical revision of this manuscript. All authors have given final approval of this version to be published, and all authors accept responsibility for its contents.

Conflict of Interest The authors declare that they have no conflict of interest.

Ethical Approval This article does not contain any studies with human participants performed by any of the authors.

Disclosures The authors declare that there is no source of support in the form of grants, bursaries, free use of equipment, drugs or any other benefits to disclose.

COVID-19 and gynecological cancers: a Moroccan point-of-view

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Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III study in IB2-IIB cervical cancer patients

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