key: cord-317956-srbualjc authors: Klang, Eyal; Soffer, Shelly; Nadkarni, Girish; Glicksberg, Ben; Freeman, Robert; Horowitz, Carol; Reich, David L; Levin, Matthew A title: Sex Differences in Age and Comorbidities for COVID-19 Mortality in Urban New York City date: 2020-08-09 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00430-w sha: doc_id: 317956 cord_uid: srbualjc Previous studies demonstrated a higher COVID-19 fatality rate in men. The aim of this study was to compare age and comorbidities between women and men who died from COVID-19. We retrospectively analyzed data of COVID-19 patients hospitalized to a large academic hospital system in New York City between March 1 and May 9, 2020. We used a multivariable logistic regression model to identify independently significant variables associated with gender in patients who died from COVID-19. The model was adjusted for age and comorbidities known to be associated with COVID-19 mortality. We identified 6760 patients diagnosed with COVID-19. Of these patients, 3018/6760 (44.6%) were women. The mortality rate was higher for men (women 18.2% vs. men 20.6%, p = 0.039). Of the patients who died, women were on average 5 years older than men (woman 77.4 ± 12.7 vs. men 72.4 ± 13.0, p < 0.001). In the multivariable model, cardiovascular comorbidities were not significantly different between women and men. Chronic kidney disease (aOR for women 0.7, 95% CI 0.5–0.9) and smoking (aOR for women 0.7, 95% CI 0.5–0.9) were more common in men. Age decile (aOR for women 1.4, 95% CI 1.3–1.6) and obesity (aOR for women 2.3, 95% CI 1.8–3.0) were higher in women. This study demonstrates that women who died of COVID-19 showed a similar cardiovascular disease profile as men. Yet, they are 5 years older than men. Investigating the gender impacts of COVID-19 is an important part of understanding the disease behavior. The coronavirus disease 2019 (COVID-19) is a pandemic viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have demonstrated that elderly patients with comorbidities are at increased risk of dying from COVID-19. Underlying health conditions such as cardiovascular disease, hypertension, and diabetes mellitus were associated with increased risk of mortality [1] [2] [3] . Smoking and obesity were also found to be risk factors [4, 5] . A number of studies have shown a higher fatality rate in men than in women [6] [7] [8] . A research conducted in China reported that 73% of the mortality cases were men [6] . It was suggested that the gender discrepancy is due to a higher smoking rate in men and subsequently a higher comorbidity rate [9] . The present study was designed to compare age and comorbidities between women and men who died from COVID-19. A multicenter observational retrospective study was conducted using data of COVID-19 patients who presented to a large We identified all patients who were positive for COVID-19 by nasopharyngeal swab polymerase chain reaction (PCR) test and were admitted to the hospitals. Demographic data, clinical information, and medical history were retrieved from the hospitals' electronic medical records. Smoking was defined as past or current smoking. Obesity was defined as body mass index (BMI) larger than 30 kg/m 2 . For 13.9% of patients with missing BMI, obesity diagnosis was retrieved from patients' files. The analysis was performed with Python (ver. 3.6.5, 64 bits). A p value of < 0.05 was considered statistically significant. Age distribution curves were plotted for women and men who died from COVID-19. Gaussian kernel density estimates were fitted to the plots. Univariate analysis compared age and comorbidities between men and women who died from COVID-19. Categorical variables were compared using chi-square test. Continuous variables were compared using Student's t test. A multivariable logistic regression model was used to identify independently significant variables associated with gender. The model was adjusted for age decile and comorbidities known to be associated with COVID-19 mortality. Adjusted odds ratios (aOR), 95% confidence intervals (CI), and p values were calculated for the variables in the models. Overall, 6760 patients were diagnosed with COVID-19. Of these patients, 3018/6760 (44.6%) were women. Of the 6760 patients, 1320 (19.5%) patients died during the study's time frame: 548/3018 (18.2%) of the women and 772/3742 (20.6%) of the men died (p = 0.039). Of the patients who died, women (mean 77.4 ± 12.7) were significantly older than men (mean 72.4 ± 13.0). Figure 1 shows the age distribution curves for women and men who died from COVID-19. The women's age distribution curve is shifted several years forward from the men's age distribution curve. In univariate analysis (Table 1) , no significant gender differences were observed for cardiovascular diseases, diabetes mellitus, and chronic obstructive pulmonary disease. Hypertension (women 79.0% vs. men 73.8%, p = 0.035) and obesity (women 37.2% vs. men 25.5%, p < 0.001) were significantly more common in women. Chronic kidney disease (women 21.7% vs. 28.9%, p = 0.004) and smoking (women 20.4% vs. men 27.7%, p = 0.003) were significantly more common in men. The results of the multivariable model are presented in Table 2 . After adjustment, there was still no significant gender difference in cardiovascular comorbidities. Features independently significant in the multivariable analysis were similar to the univariate analysis. Age decile (aOR for women 1.4, 95% Fig. 1 Age distribution plot in 1320 patients who died from COVID-19, stratified by sex. The age distribution curve for women is shifted about 5-10 years ahead of the men's age distribution curve CI 1.3-1.6) and obesity (aOR for women 2.3, 95% CI 1.8-3.0) were higher in women. Chronic kidney disease (aOR for women 0.7, 95% CI 0.5-0.9) and smoking (aOR for women 0.7, 95% CI 0.5-0.9) were higher in men. This study demonstrates that in patients who died from COVID-19, no significant difference was noted between cardiac morbidity and gender. Yet, a difference was found for age. Women who died were on average 5 years older than men. Like previous research, our data shows that mortality and hospital admission rates were higher for men. Previous studies suggested that the gender disparity is a result of behaviors such as smoking and drinking that lead to underlying cardiovascular morbidity [9] . Indeed, in our study, we found that the smoking rate was higher for men. Yet, this difference was not reflected in comorbidity differences between the genders. Obesity was more frequent among women who died. It is worthy of note that the mortality rate in our cohort is higher than that reported from different locations [10] . Our results are in accordance with other publications from the New York City area, which demonstrated a high COVID-19 mortality rate [4, 11] . The link between gender and the severity of COVID-19 disease is still not completely understood. This link can be related to a number of causes including physiological, biological, and sociological factors. In our cohort, there was a fiveyear discrepancy between men and women who died from COVID-19. One possible explanation is that the gender difference results from the association between COVID-19 mortality and underlying health conditions, particularly cardiovascular diseases. In women, cardiovascular disease starts to develop approximately 5-10 years later due to the protective effect of estrogen [12, 13] . This means that the cardiovascular injury, which may affect the course of COVID-19, begins to accumulate later in women. Our study is limited to an assessment of gender differences among patients who have died from COVID-19 without considering the comorbidity rate of men versus women in the general population. Secondly, this is a retrospective observational study, with all the associated limitations. Thirdly, due to large missing values for race, we did not include this variable in the logistic regression model. Finally, the study represents the urban New York City population, and other populations may have different results. Investigating the gender impacts of COVID-19 is an important part of understanding the disease behavior. Women who died of COVID-19 showed a similar cardiovascular disease profile as men. Yet, on average, they are 5 years older than men. The Mount Sinai Institutional Review Board (IRB) approved this study. Informed consent was waived by the IRB committee. 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The authors declare that they have no conflict of interest.