id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281551-0aj2zwx8	Schlagenhauf, Patricia	Repurposing antimalarials and other drugs for COVID-19	2020-04-02		.txt	text/plain	1433	80	50	A French paper reporting on the use of drug combinations in infected patients highlighted the possibility that hydroxychloroquine is effective in the treatment of COVID-19 patients [4] particularly in combination with azithromycin. For instance, teicoplanin was proposed as a potential treatment in COVID-19 patients and has already shown inhibitory effects on cell entry of Ebola virus, SARS-CoV and MERS-CoV in the past. However, it has to be acknowledged that in this and other cases, it is a long, expensive and time-consuming way, even if there is an accelerated avenue to expedite promising developments, from in vitro assays indicative of antiviral effects to the initiation steps of safety and efficacy assessments in humans, Finding compounds that can block the entry of the virus into the cell could be an important approach to find potential therapies for COVID-19. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2)	./cache/cord-281551-0aj2zwx8.txt	./txt/cord-281551-0aj2zwx8.txt