key: cord-276839-kxfxybq4 authors: Dursun, Zehra Beştepe; Kilic, Aysegul Ulu-; Alabay, Selma; Benli, Ali Ramazan; Çelik, İlhami title: COVID-19 among Turkish citizens returning from abroad date: 2020-09-01 journal: Travel Med Infect Dis DOI: 10.1016/j.tmaid.2020.101860 sha: doc_id: 276839 cord_uid: kxfxybq4 nan The first confirmed COVID-19 case reported from Turkey was on 11 March 2020, after a man who returned to Turkey from Europe. After that day, Turkish citizens who are abroad were evacuated back to the country and quarantined as a part of national infection control measures (1) . The Umrah pilgrims were among the quarantined being a unique cohort of people with a greater risk of acquisition viral respiratory infections due to travelling internationally and size of people performing the worship in the same place (2). In our city (Kayseri, Turkey), the last convoy returning from Umrah was arrived on 15 th March 2020. In this study, we aimed to investigate the rate of infection among returning Turkish citizens. In addition to that we examine the risk factors for severe infection among returning Umrah visitors in the same convoy. Nasal and pharyngeal swabs were obtained from all citizens as soon as they arrived the Turkish International Airports. The swabs were tested for COVID-19 by reverse transcriptase polymerase chain reaction and positive results were defined as confirmed COVID-19 cases. All of the citizens were questioned for the symptoms of COVID-19 such as fever above 38°C, cough or sore throat, myalgia and shortness of breath. Symptomatic cases were hospitalized and treated in Kayseri City Hospital. Asymptomatic cases were also housed in a separate building and isolated for 14 days. During this period, the patients who developed symptoms compatible with COVID-19 were also transferred to the Kayseri City Hospital. Laboratory tests were performed for cases including assessment of a complete blood count, liver function tests and lactate dehydrogenase. Chest radiography and computed tomography (CT) was also performed for all case patients. The confirmed cases were classified as being mild or moderate and severe. Severe disease was defined as patients with a respiratory rate >30 breaths /minute, respiratory distress and oxygen saturation (SpO2) <93%. Mild or moderate cases were defined as less severe clinical symptoms such as low-grade fever and cough with no evidence of severe pneumoniae. A total of 264 participants were enrolled (median age, 55,6 years [range, 13-87 years]; 46% male). Univariate logistic regression analysis showed that severity of the disease was significantly related with to be ≥65 years old, to have fever >37,9°C, to have myalgia and to have lower lymphocyte count. Independent predictor of severity of the disease on multivariate logistic regression were only to have fever (OR=4,1, p=0.04). In tomography findings, patients with severe disease had more frequently bilateral peripheral ground glass opacities (68% vs 44%), whereas focal consolidation was more frequently observed among patients with mild and moderate disease (18% vs 33%). Tomography findings did not significantly differ among patients. The empirical treatment of patients was covering antimicrobials against atypical pathogens, influenza virus and COVID-19 (Table) . Among all case patients, 7 (12,7%) were treated in intensive care unit, 4 (7,3%) received invasive mechanical ventilation. All four patients who required mechanical ventilation were died. Older people are at an increased risk of acquiring COVID-19 and likely to have a serious illness. The risk is higher for those people travelling in groups and worship at the holy sites without social distancing. Accordingly, the Umrah visits are thought to be a super-spreader event though the visitors are the older age of the people compared with the general population and higher risk of having a coexisting chronic disease (2). In this current study, about one third of the people was above 65, with a median age of 55 years among returning 252 pilgrims. During their 14 days of quarantine, was occurred in about one fifth of them. Rapid action in the early phase of the epidemic and ensuring an early return to the country, might be the effective in preventing the transmission of disease to large numbers of people. The lower lymphocyte counts were also previously reported to be associated with worse prognosis. In this study, the median lymphocyte count level of severe cases found 1540, however, this level was higher than previously reported studies (3, 4) . This may be because during quarantine the patients diagnosed and treated earlier before they developed deep lymphopenia. Presenting with high fever was found four times more common among patients with severe disease. The presence of a fever in the elderly is more likely to be associated with a serious viral infection than younger adults (5) . So, mass screening for fever and early recognition of severe cases may improve the prognosis especially for elderly. A small sample size of Umrah visitors included to this study was the major limitation. Infection control precautions should be implemented and strictly followed in travels particularly for mass movements such as Umrah visit. Restricting the travel of people with advanced age and chronic disease during the epidemic period, the use of masks during travel, increasing the awareness of hand hygiene and quarantine for the returning visitors for appropriate duration are among the measures that should be performed for infection control. Kayseri City Hospital, Department of Infectious Diseases Kayseri City Hospital, Department of Infectious Diseases Ministry of Health, Provincial Health Directorate New threat: 2019 novel Coronavirus infection and infection control perspective in Turkey Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study