id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032926-mrnsaexq	Waitz, Markus	Application of two different nasal CPAP levels for the treatment of respiratory distress syndrome in preterm infants—“The OPTTIMMAL-Trial”—Optimizing PEEP To The IMMAture Lungs: study protocol of a randomized controlled trial	2020-10-01		.txt	text/plain	6993	335	47	BACKGROUND: Nasal continuous positive airway pressure (CPAP) applies positive end-expiratory pressure (PEEP) and has been shown to reduce the need for intubation and invasive mechanical ventilation in very low birth weight infants with respiratory distress syndrome. Results of a secondary analysis from a cohort study in 34 international centers that participated in a nasal intermittent positive pressure ventilation trial indicate a large variation of PEEP levels used in clinical practice during neonatal resuscitation and the first 28 days of life (i.e., 3-9 cmH 2 O) [10] . The primary hypothesis of this study is that the use of a higher PEEP range in preterm infants born at 26 + 0-29 + 6 weeks gestational age (GA) receiving prophylactic nasal CPAP support after birth reduces the incidence of intubation and/or meeting predefined CPAP failure criteria within the first 120 h of life when compared to the application of a lower PEEP range.	./cache/cord-032926-mrnsaexq.txt	./txt/cord-032926-mrnsaexq.txt