id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259299-z3o4t7mz	Chinsangaram, Jarasvech	Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus	1998-10-31		.txt	text/plain	3280	163	48	title: Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus Abstract Previously, we demonstrated that a genetically engineered variant of foot-and-mouth disease virus (FMDV) serotype A12 lacking the leader proteinase-coding region (A12-LLV2) was attenuated and induced an immune response that partially protected cattle from FMD. Animals vaccinated with chemically inactivated A12-LLV2 or wild-type (WT) virus in oil adjuvant developed high levels of neutralizing antibodies and were protected from FMD upon challenge. Intramuscular vaccination of BEI-inactivated virus in adjuvant (both induced high neutralizing antibody titers (Table I) and these animals had antibodies to the viral structural proteins as detected by RIP (Figure 1) . As expected all animals Figure 3 Immunoprecipitation of viral proteins with serum from swine vaccinated with live or BEI-inactivated A12-LLV2 in the absence of adjuvant.	./cache/cord-259299-z3o4t7mz.txt	./txt/cord-259299-z3o4t7mz.txt