id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284882-8vil7k5l	MacDonald, Angus J.	rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens	2005-05-16		.txt	text/plain	3922	206	55	title: rOv-ASP-1, a recombinant secreted protein of the helminth Onchocercavolvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens After a single immunization and one boost, rOv-ASP-1 exceeded the efficacy of alum or MPL + TDM adjuvants in terms of end-point total IgG or IgG1 and IgG2a anti-OVA titres. While conducting experiments designed to evaluate recombinant Onchocerca volvulus ASP-1 (rOv-ASP-1) as a possible vaccine candidate against onchocerciasis in humans, we vaccinated mice with the recombinant protein alone or with alum or Freund's adjuvants and measured IgG1 and IgG2a isotypes that are broadly associated with Th2 and Th1 T cell responses, respectively. Having shown that rOv-ASP-1 acted as a better adjuvant than alum or MPL + TDM in stimulating production of antibodies to OVA, we then tested if the protein had similar adjuvant potency for antigens derived from human pathogens, namely SARS-CoV and HIV-1.	./cache/cord-284882-8vil7k5l.txt	./txt/cord-284882-8vil7k5l.txt