id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291510-jh2fdks4	Jiang, Yi	Recombinant infectious bronchitis coronavirus H120 with the spike protein S1 gene of the nephropathogenic IBYZ strain remains attenuated but induces protective immunity	2020-02-11		.txt	text/plain	7943	403	53	Collectively, our results suggest that the recombinant strain, rH120-S1/YZ, may represent a promising vaccine candidate against QX-like IBVs. Infectious bronchitis (IB) was first described as a respiratory disease affecting chicks in the US in 1931 as an acute and highly contagious viral disease, and continues to cause major economic loss within the poultry industry worldwide [1] [2] [3] . Commercial attenuated live vaccines used against IBV in China include the H120, LDT3, and 4/91 strains [7] ; however, phylogenetic analysis indicates that the QX-like genotype is genetically distant from the strains described above, which may explain the poor cross-protectivity against infection in chickens immunized with these classical vaccines [18, 19] . The earliest death was observed at 3 dpi in the QX-like strain rIBYZ group, which virus was highly pathogenic to one-day-old SPF chickens; the final mortality of this group was 63.3% (Fig. 3A) . Preparation and protective efficacy of a chicken embryo kidney cell-attenuation GI-19/QX-like avian infectious bronchitis virus vaccine	./cache/cord-291510-jh2fdks4.txt	./txt/cord-291510-jh2fdks4.txt