id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292528-8kdhf123	Lau, Yuk-Fai	A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic	2009-02-25		.txt	text/plain	6897	342	49	In addition, a number of studies have shown that the hemagglutinin (HA) molecules of avian H5 viruses are poorly immunogenic [1, 2] , where up to 90 g of antigen (6 times the normal dose of human influenza virus HA) was required to elicit potentially protective responses in a substantial number of subjects [2] . Intranasal administration of PIKA produced the most significant anti-influenza effect compared to s.c. or i.p. administration of the drug (Fig. 1D ) though the pul-monary viral titers in the treated mice were still significantly lower than the titers of the PBS control group (p = 0.0079). In summary, we have demonstrated that the inclusion of PIKA in two different formations of influenza vaccine can achieve substantial antigen-sparing with robust humoral immune responses, leading to potent pulmonary viral titer reduction in vivo.	./cache/cord-292528-8kdhf123.txt	./txt/cord-292528-8kdhf123.txt