id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309999-izdl0f2i	Qin, Ede	Immunogenicity and protective efficacy in monkeys of purified inactivated Vero-cell SARS vaccine	2006-02-13		.txt	text/plain	3944	205	46	Additionally, three groups of rhesus monkeys were immunized with different doses of the purified inactivated SARS vaccine (0.5, 1 and 2 μg/time/monkey) on days 0 and 7, and the monkeys were challenged with SARS-CoV GZ-01 strain. INTERPRETATION: The purified inactivated SARS vaccine could induce high levels of neutralizing antibody, and protect the monkeys from the challenge of SARS-CoV. The results showed that both the purified and the unpurified SARS vaccines can induce high levels of SARS-CoV specific neutralizing antibodies in monkeys, thus demonstrating high immunogenicity. Our observations of immunogenicity in monkeys showed that the unpurified inactivated SARS vaccine induced almost the same level of neutralizing antibody as the purified vaccine. The results indicated that the purified inactivated SARS vaccine we developed could induce high levels of neutralizing antibody, protect monkeys after a SARS-CoV challenge, and be administered safely in monkeys.	./cache/cord-309999-izdl0f2i.txt	./txt/cord-309999-izdl0f2i.txt