id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330406-a1tvcgqj	Moore, George E.	A space–time cluster of adverse events associated with canine rabies vaccine	2005-12-01		.txt	text/plain	3220	157	46	Patient risk factors and/or practice vaccination protocols may therefore influence the occurrence and potential clustering of reported VAEs. The purpose of this study was to determine if practitioner-diagnosed adverse events occurring within 3 days of canine rabies vaccine administration are clustered in space and time. In time-and-space, a significant cluster of VAE was also identified; the spatial window was not altered but the cylindrical window was reduced compared to temporal analyses alone ( Table 1) Analyses of MHG populations with adjustments for patient covariates did not alter the space-time dimensions of the most likely cluster, although the adjustment for the number of concurrently administered vaccines caused the greatest reduction (3.3%) in the ratio of observed-to-expected cases ( Table 2 ). Supportive evidence for the contribution of cases by these hospitals was indicated when space-time cluster analysis, using a Poisson model with hospital-based populations and VAE rate data adjusted for number of concurrent vaccinations, identified a significant (P = 0.001) cluster of VAE involving the same 2 hospitals during a 6-month period of September 2002 through February 2003.	./cache/cord-330406-a1tvcgqj.txt	./txt/cord-330406-a1tvcgqj.txt