id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340686-uq0fsqh3	Dwivedi, Varun	Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs	2011-05-23		.txt	text/plain	6474	333	46	title: Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs In the present study, mucosal adjuvanticity of Mycobacterium tuberculosis whole cell lysate (Mtb WCL) was evaluated in pigs administered a modified live PRRS virus vaccine (PRRS-MLV) intranasally. Importantly, an increased and early generation of PRRSV specific neutralizing antibodies were detected in PRRS-MLV+ Mtb WCL compared to pigs inoculated with vaccine alone. An increased immunosuppressive cytokine response was associated with a significant increase in the frequency of T-regulatory cells (Tregs) in the lungs of pigs receiving PRRS-MLV compared to pigs inoculated with PRRS-MLV+ Mtb WCL (Fig. 1D) . In addition, increased (but not significant) frequency of ␥␦ T cells in the lungs of PRRS-MLV+ Mtb WCL vaccinated pigs was detected at all the PID (Table 2D ).	./cache/cord-340686-uq0fsqh3.txt	./txt/cord-340686-uq0fsqh3.txt