id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290593-vhmi2559	Lannes, Nils	Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses	2012-08-30		.txt	text/plain	4412	250	49	title: Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses Vaccine-induced immune protection correlates with the presence of high levels of neutralizing antibodies but also opsonising antibodies have been proposed as an important mechanism of the immune response contributing to virus clearance by macrophages and leading to the production of type-I interferon (IFN) by plasmacytoid dendritic cells (pDC). The present study demonstrates that the opsonising antibody titres mediating enhanced IFN-α responses in pDC were similar to neutralizing titres, when antigenically related viruses from the same serotype were employed. Considering the possible importance of opsonising antibodies and pDC in the protection against FMDV, the main aim of this study was to characterize the relationship between neutralizing and opsonising activities of polyclonal sera from immunized pigs. Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes	./cache/cord-290593-vhmi2559.txt	./txt/cord-290593-vhmi2559.txt