id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295704-3w6hivv8	Vidaña, Beatriz	Involvement of the different lung compartments in the pathogenesis of pH1N1 influenza virus infection in ferrets	2016-11-08		.txt	text/plain	5799	282	41	Severe cases after pH1N1 infection are consequence of interstitial pneumonia triggered by alveolar viral replication and an exacerbated host immune response, characterized by the up-regulation of pro-inflammatory cytokines and the influx of inflammatory leukocytes to the lungs. This study aims to clarify this question by studying the different induction of innate immune molecules by the distinct lung anatomic compartments (vascular, alveolar and bronchiolar) of ferrets intratracheally infected with a human pH1N1 viral isolate, by means of laser microdissection techniques. More severe lung lesions were observed at 24 h post infection (hpi) correlating with viral antigen detection in bronchiolar and alveolar epithelial cells. As the limitations of the technique did not allow us to completely individualize the target cells, we assessed the cytokine expression associated to the viral replication in the different lung compartments (vascular, alveolar and bronchiolar).	./cache/cord-295704-3w6hivv8.txt	./txt/cord-295704-3w6hivv8.txt