id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006752-fmdvwnbw	Mao, Huawei	Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus	2014-06-17		.txt	text/plain	2671	141	56	While there are other potential explanations for this large number of human infections with an avian influenza virus, we investigated whether a lack of conserved T-cell epitopes between endemic H1N1 and H3N2 influenza viruses and the novel H7N9 virus contributes to this observation. In the 2009 H1N1 pandemic (pdmH1N1) outbreak, we analyzed the conserved CD8 T cell epitopes in pdmH1N1 virus, and demonstrated that the conserved epitope-specifi c T cells established by seasonal infl uenza virus could cross react against the pandemic virus, which might contribute to the milder pandemic H1N1 illness overall and the lower infection attack rate in young adults even though they did not have detectable cross-neutralizing antibody (Tu W, et al., 2010) . Like avian H5N1 infection, most of patients with H7N9 infection who were hospitalized for medical care had severe illness, although both of the two viruses had conserved T cell epitopes that are shared with seasonal infl uenza virus.	./cache/cord-006752-fmdvwnbw.txt	./txt/cord-006752-fmdvwnbw.txt