id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322166-ajolu2rh	Yin, Jingchuan	An overview of the highly pathogenic H5N1 influenza virus	2013-01-16		.txt	text/plain	6890	306	50	The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. Disrupted cytokine and chemokine expression, especially IFNs and TNF, and decreased antiviral activity of innate immune response mediators, such as protein kinase resource and retinoic acid-inducible gene product I (RIG-I), directly lead to increased virulence of the virus (Haye K, et al., 2009; Jackson D, et al., 2008; Lipatov A S, et al., 2005; Munir M, et al., 2011) . Thus, patients with H5N1 disease typically present with a hyper-induced systemic inflammatory response syndrome and a higher and a more prolonged viral load in respiratory specimens than other seasonal influenza virus like human H1N1 viruses (Chan M C, et al., 2005; Kuiken T, et al., 2010; Lee D C, et al., 2012; Peiris J S, et al., 2010; Sandbulte M R, et al., 2008) .	./cache/cord-322166-ajolu2rh.txt	./txt/cord-322166-ajolu2rh.txt