id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252615-ajyv95pu	Lu, Yanfang	ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons	2016-05-27		.txt	text/plain	4186	280	54	Although 3A protein had no effect on the expression of ATP1B3, EV71 infection resulted in elevated expression of ATP1B3 in RD cell line, both on messenger RNA (mRNA) and protein levels. Our study demonstrated that ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection. We observed that both the mRNA and protein levels of ATP1B3 in RD cells were positively correlated with the infection doses of EV71 (Fig. 3B) . We infected ATP1B3 overpression cells or vector controls with EV71 at an MOI of 1, cultured cells with anti-human interferon-α1/β antibodies or isotype control IgG, and examined the viral replication using RT-PCR assay. Previous studies have shown that EV71 infection can induce IFN-β production which is dependent on the infectious dose, but the interferon is not cell type specific (Lu et al., 2012) .	./cache/cord-252615-ajyv95pu.txt	./txt/cord-252615-ajyv95pu.txt