id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255453-7e40rj1y	Oliver, S.L.	Genomic characterization of the unclassified bovine enteric virus Newbury agent-1 (Newbury1) endorses a new genus in the family Caliciviridae	2006-06-20		.txt	text/plain	6227	303	53	The relationship of Bo/Newbury1/1976/UK with members of the Caliciviridae Although many features of the Newbury1 genome organization were consistent with the Caliciviridae, the Newbury1 genome had low nucleotide (≤47%) and amino acid (≤39%) identities to all representative viruses of the 4 Caliciviridae genera by comparison of complete non-structural genes (2Chelicase, 3C-protease, 3D-polymerase), complete capsids, capsid subdomains and the 3′ terminal ORF genes ( Table 2 ). Newbury1 failed to group phylogenetically with the 4 recognized Caliciviridae genera but formed a separate clade with NB virus by UPGMA, Fitch-Margoliash, parsimony and maximum likelihood analyses of the nucleotide and translated amino acids of ORF1 (excluding the capsid gene), the individual regions that encoded the 2C-helicase, 3C-protease, 3D-polymerase and complete capsid genes (not shown). The distant relationship of Newbury1 to the 4 recognized Caliciviridae genera was confirmed using additional phylogenetic analyses based on amino acid alignments generated from homology models of structurally conserved regions of the partial polymerase and the capsid S-domain (Fig. 3) .	./cache/cord-255453-7e40rj1y.txt	./txt/cord-255453-7e40rj1y.txt