id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255773-b4re5bky	Zhang, Qingzhan	Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1	2016-01-14		.txt	text/plain	9880	584	52	title: Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1 We showed that PEDV suppressed the type I interferon production and ISGs expression in these cells, and identified nsp1, nsp3, nsp7, nsp14, nsp15, nsp16, E, M, N and ORF3 as the viral IFN antagonists. The CBP degradation is a novel mechanism of coronavirus nsp1 for IFN suppression and our study provides a new insight into the immune modulation and evasion strategy of PEDV. MARC-145 cells have been used to study type I IFN signaling of porcine arterivirus (Kim et al., 2010; Overend et al., 2007; Patel et al., 2010) , and thus infection of these cells One μg of each of the cloned genes was transfected to HeLa cells in 12-well plates, and protein expression was determined by immunofluorescence (B) and	./cache/cord-255773-b4re5bky.txt	./txt/cord-255773-b4re5bky.txt