id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258691-cd83w9o6	Whitman, Lucia	IFN-γ-mediated suppression of coronavirus replication in glial-committed progenitor cells	2009-02-01		.txt	text/plain	4938	257	40	IFN-γ-mediated control of JHMV replication is dampened in glial cultures derived from the neural progenitor cells of type I receptor knock-out mice. These data indicate that JHMV is capable of infecting glial cells generated from neural progenitor cells and that IFN-γ-mediated control of viral replication is dependent, in part, on type I IFN secretion. In the present study, we demonstrate that primary cultures of glia derived from neural progenitor cells are susceptible to JHMV infection and support viral replication. Therefore, these findings provide, to our knowledge, the first demonstration that glia-committed cells derived from neural precursors are susceptible to JHMV infection as well as identify a potential mechanism responsible for controlling viral replication. These findings indicate that differentiated cells derived from neural progenitors are susceptible to JHMV infection and are capable of supporting replicating virus which results in extensive cytopathology.	./cache/cord-258691-cd83w9o6.txt	./txt/cord-258691-cd83w9o6.txt