id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266617-z8uecyl6	Pavesi, Angelo	Asymmetric evolution in viral overlapping genes is a source of selective protein adaptation	2019-04-03		.txt	text/plain	6677	326	52	Analysis of nucleotide and amino acid sequences revealed that half of overlaps undergo asymmetric evolution, as the protein from one frame shows a number of substitutions significantly higher than that of the protein from the other frame. I classified a pair of homologous overlaps as a case of symmetric evolution, if the number of amino acid substitutions in the Up1-Up2 alignment did not significantly differ from that in the Down1-Down2 alignment (chi-square < 3.84). In alternative, I classified a pair of homologous overlaps as a case of asymmetric evolution, if the number of amino acid substitutions in the Up1-Up2 alignment was significantly different from that in the Down1-Down2 alignment (chi-square > 3.84). The analysis of the pattern of nucleotide substitutions in the 75 pairs of homologous overlaps revealed 39 and 36 cases of symmetric and asymmetric evolution, respectively (Supplementary Table S2 ).	./cache/cord-266617-z8uecyl6.txt	./txt/cord-266617-z8uecyl6.txt