id author title date pages extension mime words sentences flesch summary cache txt cord-268341-103xf3dw Parra, Beatriz Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis 1997-07-07 .txt text/plain 5778 316 49 the plaque size and pathogenesis similar to the parental During JHMV infection of the CNS there is an abrupt suckling mouse brain pool of JHMV originally described increase in mRNA encoding interleukin-1 (a and b), ILby Weiner (1973) and produces a lethal encephalomyeli-6, tumor necrosis factor (TNF)-a, and interferon (IFN)-g, tis with minimal demyelination apparent at the time of at the time of maximal decrease in virus replication and death. Similar of mice through Day 5 postinfection, consistent with the to the kinetics of IFN-g, TNF-a mRNA increased until rapid accumulation of both NK and T cells in the CNS of death of lethally infected mice. Similarly, the adoptive transfer at the time most lethally infected mice were about to succumb to infection (Day 7), there was no difference in the of virus-specific CD4 / T cells to JHMV-infected mice demonstrates that some clones protect via reducing viral peak levels of IL-10 mRNA between the two groups. ./cache/cord-268341-103xf3dw.txt ./txt/cord-268341-103xf3dw.txt