id author title date pages extension mime words sentences flesch summary cache txt cord-268467-btfz6ye8 Schreiber, Steven S. Sequence analysis of the nucleocapsid protein gene of human coronavirus 229E 1989-03-31 .txt text/plain 5035 343 59 The 3′-noncoding region of the genome contains an 11-nucleotide sequence, which is relatively conserved throughout the Coronavirus family and lends support to the theory that this region is important for the replication of negative-strand RNA. This result suggested that the HCV229E subgenomic mRNAs possess a nested-set structure similar to other coronaviruses and that A34 represented a cDNA clone of either the 3'-end of the genomic RNA or the leader sequence. The 3'-noncoding region contains the sequence TGGAAGAGCCA, 75 nucleotides from the 3'-end (Fig. 4) which is relatively conserved among coronaviruses and is found at approximately the same location in all of these viral genomes (Kapke and Brian, 1986; Skinner and Siddell, 1984; Armstrong et a/., 1983; Lapps et al., 1987; Kamahora et a/., 1988; Boursnell et al., 1985) ( Table 1) . Three intergenic regions of coronavirus mouse hepatitis virus strain A59 genome RNA contain a common nucleotide sequence that is homologous to the 3'end of the viral mRNA leader sequence ./cache/cord-268467-btfz6ye8.txt ./txt/cord-268467-btfz6ye8.txt