id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269419-68kja6bg	Hu, Weibin	Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient	2013-01-20		.txt	text/plain	4330	256	53	title: Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient In this study, we used the full-length HA protein from the 2009 pandemic H1N1 influenza virus to raise fully human neutralizing mAbs. We obtained 19 monoclonal antibodies from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient and confirmed that all 19 of the monoclonal antibodies recognized the lysates of both the pandemic virus and the recently circulating seasonal H1N1 influenza virus. Interestingly, we found that most of the monoclonal antibodies, including the seven neutralizing mAbs, bound to the HA stem region (HA2), which is relatively conserved among different influenza A virus strains. These findings indicate that a broad cross-subtype neutralizing antibody response targeting the HA stem region exists in individuals vaccinated against 2009 pandemic H1N1 influenza and that these broadly reactive memory B cells may be important for protecting humans from infection with different influenza A viruses.	./cache/cord-269419-68kja6bg.txt	./txt/cord-269419-68kja6bg.txt