id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272437-gvzfl8c3	Zhao, Jing	Replicase 1a gene plays a critical role in pathogenesis of avian coronavirus infectious bronchitis virus	2020-08-20		.txt	text/plain	565	51	57	title: Replicase 1a gene plays a critical role in pathogenesis of avian coronavirus infectious bronchitis virus Avian coronavirus infectious bronchitis virus (IBV) is an important pathogen threatening poultry production worldwide. Our findings demonstrate that the replicase 1a gene of avian coronavirus IBV is a determinant of pathogenicity. In this study, we used an IBV reverse genetics system based on virulent strain Fig. 2. Recombinant live attenuated avian coronavirus 431 vaccines with deletions in the accessory genes 3ab and/or 5ab protect against infectious 432 bronchitis in chickens attenuated Chinese QX-like infectious bronchitis virus strain as a candidate vaccine S gene and 5a accessory gene 455 are responsible for the attenuation of virulent infectious bronchitis coronavirus	./cache/cord-272437-gvzfl8c3.txt	./txt/cord-272437-gvzfl8c3.txt